CR in rodents

Inhibition of the insulin/IGF-1/mTOR signaling path- way may be an essential mechanism through which pro-longevity interventions (e.g., rapamycin, calorie restriction) extend lifespan (Blagosklonny, 2009;Lamming, 2014; Lamming and An- derson, 2014)
The underlying molecular process responsible for the enhanced insulin sensitivity appears to be associated with increased activation of certain insulin signaling elements [ Prasannarong 12 ]
See: Life-extension experiments