Entropy

"Entropy, in its purest form, is used in many aspects of science, such as chemistry. But there's more to it that you do not understand. A massive amount of entropy in the universe creates ripples, like a stone in a stream. However, that stone gets bigger the more entropy there is, until eventually, the stream becomes dammed." - Saint Germain
Entropy, also known as S, or \Delta
S in relation to the change of entropy, is a scientific concept and physical property, referring to the amount of disorder in the universe.
Entropy is responsible for setting in motion a majority of the events of the story, as extremely large amounts of entropy in the universe can cause further disorder. Certain entities such as La Karakha use this disorder and convert it into energy which it uses to sustain itself to become stronger. In order for the universe to be at peace, any time anomalies, if any, must be corrected to decrease the amount of entropy in the universe, and any interfering persons who cause the universal entropy to increase must be stopped.