Protein sequence:
MSDADPFDMSDDDDNSVLSHTPPKKQKKAPTTKKGGSKPLADVENESFMDGIEESNNQDKDTNVSEKYQKLTQLEHIIKRPDTYVGSTERTTQHMWVYSSESEGMEYREVSYVPGLYKIFDEIVVNAADNKQNDKNMDEIRVTIDRESGEISVWNNGRGIPIEMHSKEKMYVPELIFGHLLTSSNYDDTQMKVTGGRNGFGAKLCNVFSTEFTIETQDSRQKKKYKQTWTENMTKMGKAKITDAKGADYTKVTFKPDYAKFGMTGMDDDFEALVKRRVYDLAGTAKVAVKLNGSRIPIRNFKMYMEMYTKAIRRERGDMGPAGKNEIITCSPDPRWEVGFAVSDGAFQQVSFVNSIAITSGGTHVNYIADQICSKLAEQVKKKNKNGATLKPAQIRNHIFIFVNALIVNPAFTSQTKEQLTTKQSQFGSKCVLEEDFYKKILKTEVMTNILHFAQQKADQMLKKTDGGRRSRMNNPKLTDANKAGTKEGHHCTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQIAKNQEIQNIKNFIGLQHKKEYTDTRGLRYGHLMITTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFITPIVKVWKGDPKNPTKQRSFFTMPEYEAWKEEHGHERGWEHKYYKGLGTSTTEDAQIYFRDLDRHLKEFHTMQDNEVELIELAFSKKKADERKGNVRQFRPGTFLDHSVDKITYTDFINKELILFSMADNIRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGTTAYQHGEGSLQQTIVGLAQTFVGSNNVNCLEPSGNFGSRLQGGADCASARYIYTRLWPFARRVFHNHDDPLLTYNEDDGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPEDIVENLKRMMDGEPLKPMQPWFRGFTGEVTAVGQDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHMKTAIAEGLEEKFKLSKTMTTTNLVAFDPERITKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKELDKLSNQARFVQMIIDGKLVISKKKKAVLVAELKEKDFKPFPKVKEAVKAGETEPVVEEEEDSESGDTEVLSNSYDYLLGMPIWSLTQERVEKLRRQIGDKELEIDTLIKLSKEDIWKRDLEDFINEWRFQNDEEARRQRKVANMGRRTSSKLMTTGRGGGAAARKRKAALGDDPDDEDFAAPKSKKSAAAKKTESKGGGLLSFLGKSSAKPKPSPADGGDSDDDFDMEIMPKKSRGAPKSEPKADPKPKDEDEDIVMEDSDIEEIIPKKSRGSSKPSVKPESEDGQAKIAEAPKRGRAAAKPKPKPKSEDEEDELDDDDFMEITKAEAAKPSAQPARSGRKTTKYAELSDSDSDNGDDLLGDVSKMVKGIGSTNGASTSDSRLLFSERSRPGSSAGLKTTASKASKPSEFDADETDYSKLVPSNTPRRSLQVKPKDAKVSDDNEPEDDDDEPVKPAAKGKAAAKGKSTAAAANQLLQRLVVGRRKMLPKPPPRLPCPLPQRRTHRSNPRPRRPRRRS

Annotated regions:
phrase: CTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQIAKNQEIQNIKNFIGLQHKKEYTDTRGLRYGHLMITTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFL
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: CTLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQIAKNQEIQNIKNFIGLQHKKEYTDTRGLRYGHLMITTDQDHDGSHIKGLLINFLQAQFPSLLKIPEFLIEFI
type: DOMAIN
name: TOPRIM_TopoII
description: DNA topoisomerase 2, TOPRIM domain

phrase: TLILTEGDSAKGLAMAGRAVVGPDLFGVFPLRGKLLNVRDASFDQIAKNQEIQNIKNFIGLQHKKEYTDTRGLRYGHLMITTDQDHDGSHIKGLLINFL
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: SYVPGLYKIFDEIVVNAADNKQNDKNMDEIRVTIDRESGEISVWNNGRGIPIEMHSKEKMYVPELIFGHLLTSSNYDDTQMKVTGGRNGFGAKLCNVFSTEFTIETQDSRQKKKYKQTWTENMTKMGKAKITDAKGADYTKVTFKPDYA
type: DOMAIN
name: HATPase_dom
description: Histidine kinase/HSP90-like ATPase domain

phrase: FITPIVKVWKGDPKNPTKQRSFFTMPEYEAWKEEHGHERGWEHKYYKGLGTSTTEDAQIYFRDLDRHLKEFHTMQDNEVELIELAFSKKKADERKGNVRQFRPGTFLDHSVDKITYTDFINKELILFSMAD
type: DOMAIN
name: TOPRIM_C
description: C-terminal associated domain of TOPRIM

phrase: LTEGDSAK
type: CONSERVED_SITE
name: TopoIIA_CS
description: DNA topoisomerase, type IIA, conserved site

phrase: NIRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGTTAYQHGEGSLQQTIVGLAQTFVGSNNVNCLEPSGNFGSRLQGGADCASARYIYTRLWPFARRVFHNHDDPLLTYNEDDGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPEDIVENLKRMMDGEPLKPMQPWFRGFTGEVTAVGQDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHMKTAIAEGLEEKFKLSKTMTTTNLVAFDPERITKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKELDKLSNQARFVQMIIDGKLVISKKKKAVLVAELKEKDFKPFPKVKEAVKAGETEPVVEEEEDSESGDTEVLSNSYDYLLGMPIWSLTQERVEKLRRQIGDKELEIDTLIKLSKEDIWKRDLED
type: DOMAIN
name: Topo_IIA_dom_A
description: DNA topoisomerase, type IIA, domain A

phrase: RSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGTTAYQHGEGSLQQTIVGLAQTFVGSNNVNCLEPSGNFGSRLQGGADCASARYIYTRLWPFARRVFHNHDDPLLTYNEDDGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPEDIVENLKRMMDGEPLKPMQPWFRGFTGEVTAVGQDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHMKTAIAEGLEEKFKLSKTMTTTNLVAFDPERITKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKELDKLSNQARFVQMIIDGKLVISKKKKAVLVAELKEKDFKPFPKVKEAVKAGETEPVVEEEEDSESGDTEVLSNSYDYLLGMPIWSLTQERVEKLRRQIGDKELEIDTLIKLSKEDIWKRD
type: DOMAIN
name: Topo_IIA_dom_A
description: DNA topoisomerase, type IIA, domain A

phrase: IITCSPDPRWEVGFAVSDGAFQQVSFVNSIAITSGGTHVNYIADQICSKLAEQVKKKNKNGATLKPAQIRNHIFIFVNALIVNPAFTSQTKEQLTTKQSQFGSKCVLEEDFYKKILKTEVMTNILHFAQQKADQMLK
type: DOMAIN
name: Topo_IIA_bsu_dom2
description: DNA topoisomerase, type IIA, subunit B, domain 2

phrase: GLYKIFDEIVVNAADNKQNDKNMDEIRVTIDRESGEISVWNNGRGIPIEMHSKEKMYVPELIFGHLLTSSNYDDTQMKVTGGRNGFGAKLCNVFS
type: DOMAIN
name: HATPase_dom
description: Histidine kinase/HSP90-like ATPase domain

phrase: ITYTDFINKELILFSMADNIRSIPSVVDGLKPGQRKVLYTCFRRNLKKDMKVVELAGHVSGTTAYQHGEGSLQQTIVGLAQTFVGSNNVNCLEPSGNFGSRLQGGADCASARYIYTRLWPFARRVFHNHDDPLLTYNEDDGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPEDIVENLKRMMDGEPLKPMQPWFRGFTGEVTAVGQDRFKFSGIIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAEKTPSFIKDYKDYNTHTKVHFVIQMDEKHMKTAIAEGLEEKFKLSKTMTTTNLVAFDPERITKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKELDKLSNQARFVQMIIDGKLVISKKKKAVLVAELKEKDFKPFPKVKEAVKAGETEPVVEEEEDSESGDTEVLSNSYDYLLGMPIWSLTQERVEKLRRQIGDKELEIDTLIKLSKEDIWK
type: DOMAIN
name: Topo_IIA_dom_A
description: DNA topoisomerase, type IIA, domain A