Protein sequence:
MKKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQETLKEFYYPFMRKIEEGKTKIASQKTVTKLGESCPDCGGELAIRKGRFGEFVACLNFPKCKYSRNLKSESKNESENTAAKAKANGTGITCPSCQKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGETLVIKELKKGTFLECLKCKIKKEMKD

Annotated regions:
phrase: VYLATDEDREGEA
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LSAGRVQSAALKIIVDRE
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: MGVITYMRT
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LYTLIYNRFLACQMSP
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: GIGRPSTYAPTISI
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: EKCEECGETLVIKELKKGTFLECLKCKIKK
type: DOMAIN
name: Topo_IA_Znf
description: DNA topoisomerase, type IA, zn finger

phrase: ITCPSCQKGEIVERFSKRGKFYGCSAYPKCNFISKYK
type: DOMAIN
name: Topo_IA_Znf
description: DNA topoisomerase, type IA, zn finger

phrase: GESCPDCGGELAIRKGRFGEFVACLNFPKCKYSRNLK
type: DOMAIN
name: Topo_IA_Znf
description: DNA topoisomerase, type IA, zn finger

phrase: KNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDE
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: VNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQETLKEFYYPFMRK
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: QKLYEGVNTHEGVMGVITYMRT
type: ACTIVE_SITE
name: Topo_IA_AS
description: DNA topoisomerase, type IA, active site

phrase: LNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQET
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: ESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNV
type: DOMAIN
name: Topo_IA_DNA-bd_dom
description: DNA topoisomerase, type IA, DNA-binding domain

phrase: LIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHE
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: KNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHE
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: KNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKN
type: DOMAIN
name: TOPRIM_TopoI
description: DNA topoisomerase 1, TOPRIM domain

phrase: TLPRIVFHEITKSAIENALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYF
type: DOMAIN
name: Topo_IA_2
description: DNA topoisomerase, type IA, domain 2