Protein sequence:
MKLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAPDFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHLQQCLKLSNPLRVTFNEITANAVKASLVAPRTIDVKRVAAQEARRVLDRLVGYMVSPELSRLTGKRLSAGRVQSPAVRLVVEREREIKAFKVTNHFGAMLFFADAKTSGEWSAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKAVVVKSFDESEAKRSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDIYAVSVKLGLDIAEKPRKFKAPAGAQVGHPAVTPTHWEVEEAGETSDQKALYKLIRLRAIACQLADARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPVCAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNIVSRGYVKTEKKYLFPTETGELIVDSLVGKFEFLDLGFTREIEESLDRIAQGESGYKAVIAKVHDQLNMELSTLQVSATPKHPCQECGKPLRRIPGKNGHFWGCSGYPDCSVTFPDEGGKPGQKKPVEVSNFACVKCGNPLKHLVKKGKGGYDFWGCSGFKEGCKATYEDKKGKPNFEKAK

Annotated regions:
phrase: DESEAKRSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDIYAVSVKLGLDIAEKPRKFKAPAGAQVGHPAVTPTHWEVEEAGETSDQKALYKLIRLRAIACQLADARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPVCAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNIVSRGYVKTEKKYLFPTETGELI
type: DOMAIN
name: Topo_IA_DNA-bd_dom
description: DNA topoisomerase, type IA, DNA-binding domain

phrase: MKLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAPDFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHLQQCLKLSN
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: NPLRVTFNEITANAVKASLVAPRTIDVKRVAAQEARRVLDRLVGYMVSPELSRLTGKRLSAGRVQSPAVRLVVEREREIKAFKVTNHF
type: DOMAIN
name: Topo_IA_2
description: DNA topoisomerase, type IA, domain 2

phrase: KLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAPDFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHLQQCLKLSNPLRVTFNE
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: CVKCGNPLKHLVKKGKGGYDFWGCSGFKEGCKATYEDK
type: DOMAIN
name: Topo_IA_Znf
description: DNA topoisomerase, type IA, zn finger

phrase: CQECGKPLRRIPGKNGHFWGCSGYPDCSVTF
type: DOMAIN
name: Topo_IA_Znf
description: DNA topoisomerase, type IA, zn finger

phrase: VYLATDPDREGEA
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LSAGRVQSPAVRLVVERE
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: QGHITYHRT
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LYKLIRLRAIACQLAD
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: GIGRPATYAAIMDN
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: MKLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAPDFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHLQQCLKLSNPLRVTFNEITANAVKASLVA
type: DOMAIN
name: TOPRIM_TopoI
description: DNA topoisomerase 1, TOPRIM domain

phrase: IDVKRVAAQEARRVLDRLVGYMVSPELSRLTGKRLSAGRVQSPAVRLVVEREREIKAFKVTNHFGAMLFFADAKTSGEWSAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKAVVVKSFDESEAKRSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDIYAVSVKLGLDIAEKPRKFKAPAGAQVGHPAVTPTHWEVEEAGETSDQKALYKLIRLRAIACQLADARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPVCAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNIVSRGYVKTEKKYLFPTETGELIVDSLVGKFEFLDLGFTREIEESLDRIAQGESGYKAV
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: MKLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAPDFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHLQQCLKLSNPLRVTFNEIT
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: KRVAAQEARRVLDRLVGYMVSPELSRLTGKRLSAGRVQSPAVRLVVEREREIKAFKVTNHFGAMLFFADAKTSGEWSAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKAVVVKSFDESEAKRSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDIYAVSVKLGLDIAEKPRKFKAPAGAQVGHPAVTPTHWEVEEAGETSDQKALYKLIRLRAIACQLADARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPVCAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNIVSRGYVKTEKKYLFPTETGELIVDSLVGKFEFLDLGFTREIEESLDRIAQGESGYKAVIAKVHDQL
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: QKLYEQGHITYHRT
type: ACTIVE_SITE
name: Topo_IA_AS
description: DNA topoisomerase, type IA, active site