Protein sequence:
MNSIQVKNEPMLASFASTSTNGKAKRSAKPSLFSGSEVSSDDDEEKPLAKRPKVEDSDSDAPLTSTVSSQNGVQKRSGSSNNDDNDDDSDSDSDAPLTALVKKSNGSDDDEDDDDDDDEGDDDDEEDDDDDDDDDDKPLSKSSKSNRKPPKTMSITGSGEKKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFEKARKLDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCEHAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQGLLEQTEEWLKSRPNAAEREINQTNLRLAYNEANRQVAILCNHQKTVNPMLLNRNLERTQDKIFQIRYEIMKEQQKILTFHKVSELKKEFKVKEHPFMKQFDKIMQKQDLDAEKVKQYEEQMISDKKSKLESTFKRQQSELQYQLEQKGLTGDDGTPKKGKKAKNVEEEVRSSIKGFKDKKQVDEELKALNETAKRLEKERKTNKSQATSCNFVSSAKKILSKYEMIKKQEAELVNKNNTSDVALSTSKLNYIDPRITLAWLKEWDDRLSDLGQGKAAPKKKVKKEEEENDIKPKKKDAKGAASKKRAAKTGLANSTGDSEKMELGLQVMNISQFFANALQKKFKWAASGDDGRDISAKWVFVKDAQSKMRKLDSAERKGQKGGSMAAMTDAADSKEAQPKVNCVLKKQTSADRKMSKPIKAVDKTEESDDDLSSDSSDDEDKPLAAVV

Annotated regions:
phrase: KWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFL
type: DOMAIN
name: Topoisomer_I_DNA-bd
description: DNA topoisomerase I, DNA-binding domain

phrase: TSNFKTNSDREKFEKARKLDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCEHAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQGLLEQTEEWLKSRPNAAEREINQTNLRLAYNEANRQVAILCNHQKTVNPMLLNRNLERTQDKIFQIRYEIMKEQQ
type: DOMAIN
name: TopoI_cat_euk
description: DNA topoisomerase I, catalytic core, eukaryotic-type

phrase: NSDREKFEKARKLDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCEHAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQGLLEQTEEWLKSRPNAAEREINQTNLRLAYNEANRQVAILCNHQKT
type: DOMAIN
name: TopoI_cat_euk
description: DNA topoisomerase I, catalytic core, eukaryotic-type

phrase: KKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVF
type: DOMAIN
name: TopoI_DNA-bd_euk
description: DNA topoisomerase I, DNA binding, eukaryotic-type

phrase: LFLGRGAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFEKARKLDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCEHAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQGLLEQTEEWLKSRPNAAEREINQTNLRLAYNEANRQVAILCNHQKTVNPMLLNRNLERTQDKIFQIRYEIMKEQQKILTFHKVSELKKEFKVKEHPFMKQFDKIMQKQDLDAEKVKQYEEQMISDKKSKLESTFKRQQSELQYQLEQKGLTGDDGTPKKGKKAKNVEEEVRSSIKGFKDKKQVDEELKALNETAKRLEKERKTNKSQATSCNFVSSAKKILSKYEMIKKQEAELVNKNNTSDVALSTSKLNYIDPRITLAWLKEW
type: DOMAIN
name: TopoI_euk
description: DNA topoisomerase I, eukaryotic-type

phrase: MIKKQEAELVNKNNTSDVALSTSKLNYIDPRITLAWLKEW
type: DOMAIN
name: TopoI_C_dom
description: Topoisomerase I C-terminal domain

phrase: NTSDVALSTSKLNYIDPR
type: ACTIVE_SITE
name: TopoI_AS
description: DNA topoisomerase I, active site