Protein sequence:
MSILILLESPGKISKISSILGKNYVVKASMGHFRDLDPKKMSIDFDNDFEPVYIVTKPDVVKNLKSAMKNIDLVYLAADEDREGEAIAQSLYDVLKPSNYKRLRFNAITKDAIMSAIKNAGDIDKNLVDAQKARRVLDRLFGYLISPILQRQIGGKLSAGRVQSVTVRIIIDKENEIKNFINKNADSSYFKVSGTFNGAKATLHESNDKKPFDLETAYKGKTAQIALINSENPNSKVVNFMKRCLKSQFFIHSVEDKMTTRSPAPPFTTSTLQQEANRKFGMSIDSTMKTAQKLYEGGYITYMRTDSVEISAEGHRDIKKIITDQYGADYYQKNLYKNKAANSQEAHEAIRPTHPELLTLEGEIEDAYQIKLYKLIWQRTIASQMKPAKIKVTIIQISISKYVEDKLNPFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKNFTGKIPTVGSKVTMEEIIARQEYMRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINREYVKITDVPGIKKDITIYSIKSENKKHIMEVYEDTDTILLGKENKKIVPTNLGITVNDFLMKYFPEFLDYKFTANMETDLDYVSTGTKNWVDIVQDFYDKLKPIVDELSKQKGLSQSSERLLGEDNDGNEITATKTKFGPVVRKKIGDKYVYAKIKDPLTLDTIKLSDAIKLLEYPKNLGQYKGFDVLLQKGDYGFYLSYNKENFSLGEIDDPEDINLDTAIKAIEAKKANNIAEFNLTENGKKIKAIVLNGKYGYYVQVTRNRIKKNYPIPKDLDPNNLTEQQILSIISVKKTYKKSAPKGGSKTIRKPSQTKYSQTKSTKSTKSTKSTNKKFVGKSAKKTTKKTTKK

Annotated regions:
phrase: QKLYEGGYITYMRT
type: ACTIVE_SITE
name: Topo_IA_AS
description: DNA topoisomerase, type IA, active site

phrase: NYKRLRFNAITKDAIMSAIKNAGDIDKNLVDAQKARRVLDRLFGYLISPILQRQIGGKLSAGRVQSVTVRIIIDKENEIKNFINKNADSSYF
type: DOMAIN
name: Topo_IA_2
description: DNA topoisomerase, type IA, domain 2

phrase: VLLQKGDYGFYLSYNKENFSLGEIDDPEDINLDTAIKAIEAKK
type: REPEAT
name: Toprim_C_rpt
description: Topoisomerase C-terminal repeat

phrase: ENGKKIKAIVLNGKYGYYVQVTRNRIKKNYPIPKDLDPNNLTEQQILSIISVKKTYKK
type: REPEAT
name: Toprim_C_rpt
description: Topoisomerase C-terminal repeat

phrase: LILLESPGKISKISSILGKNYVVKASMGHFRDLDPKKMSIDFDNDFEPVYIVTKPDVVKNLKSAMKNIDLVYLAADEDREGEAIAQSLYDVLKPSNYKRLRFNA
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: NLVDAQKARRVLDRLFGYLISPILQRQIGGKLSAGRVQSVTVRIIIDKENEIKNFINKNADSSYFKVSGTFNGAKATLHESNDKKPFDLETAYKGKTAQIALINSENPNSKVVNFMKRCLKSQFFIHSVEDKMTTRSPAPPFTTSTLQQEANRKFGMSIDSTMKTAQKLYEGGYITYMRTDSVEISAEGHRDIKKIITDQYGADYYQKNLYKNKAANSQEAHEAIRPTHPELLTLEGEIEDAYQIKLYKLIWQRTIASQMKPAKIKVTIIQISISKYVEDKLNPFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKNFTGKIPTVGSKVTMEEIIARQEYMRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINREYVKITDVPGIKKDITIYSIKSENKKHIMEVYEDTDTILLGKENKKIVPTNLGITVNDFLMKYFPEFLDYKFTANMETDLDYVSTGTKNWVDIVQDFYDKLKPI
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: SILILLESPGKISKISSILGKNYVVKASMGHFRDLDPKKMSIDFDNDFEPVYIVTKPDVVKNLKSAMKNIDLVYLAADEDREGEAIAQSLYDVLKPSN
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: EDKMTTRSPAPPFTTSTLQQEANRKFGMSIDSTMKTAQKLYEGGYITYMRTDSVEISAEGHRDIKKIITDQYGADYYQKNLYKNKAANSQEAHEAIRPTHPELLTLEGEIEDAYQIKLYKLIWQRTIASQMKPAKIKVTIIQISISKYVEDKLNPFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKNFTGKIPTVGSKVTMEEIIARQEYMRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINREYVKITDVPGIKKDI
type: DOMAIN
name: Topo_IA_DNA-bd_dom
description: DNA topoisomerase, type IA, DNA-binding domain

phrase: SILILLESPGKISKISSILGKNYVVKASMGHFRDLDPKKMSIDFDNDFEPVYIVTKPDVVKNLKSAMKNIDLVYLAADEDREGEAIAQSLYDVLKPSNYKRLRFNAIT
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: VYLAADEDREGEA
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LSAGRVQSVTVRIIIDKE
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: GGYITYMRT
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LYKLIWQRTIASQMKP
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: GIGRPSTYVNTIKT
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: IDKNLVDAQKARRVLDRLFGYLISPILQRQIGGKLSAGRVQSVTVRIIIDKENEIKNFINKNADSSYFKVSGTFNGAKATLHESNDKKPFDLETAYKGKTAQIALINSENPNSKVVNFMKRCLKSQFFIHSVEDKMTTRSPAPPFTTSTLQQEANRKFGMSIDSTMKTAQKLYEGGYITYMRTDSVEISAEGHRDIKKIITDQYGADYYQKNLYKNKAANSQEAHEAIRPTHPELLTLEGEIEDAYQIKLYKLIWQRTIASQMKPAKIKVTIIQISISKYVEDKLNPFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKNFTGKIPTVGSKVTMEEIIARQEYMRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINREYVK
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: KENKKIVPTNLGITVNDFLMKYFPEFLDYKFTANMETDLDYVSTGTKNWVDI
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central