Protein sequence:
MACLTMANIEGSATATVHQNGDILGNTSAPKQTEPLLQVYLYYSPGKTGGDYLQFPAGEYVAEEICIVACKACGIMPVYHNMFALMSETERVWYPPNHIFHVDEATRLKLLYRIRFYFPHWYCNGTSRACRYGIIRGSESPVLDDLVMSYLFAQWRKDFLDGWIQMPVTHETQEECLGMAVLDMMRVAKEKDQTPLAVYNSVSYKMFLPKCVRAKIQEYHILTRKRIRYRFRKFIQQFGQCKATARNLKLKYLINLETLQSAFYSEVFEVKEPGGDPSGEESFATIVITGNGGIQCSRGKLKNCETLAEQDLQTYCDFPDIIDVSIKQASQEGSSERRIVTIHKQDSKNLEAEFQSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPSVLENIQSNCHGPIFMDFAINKLKKAGNQTGFYVLRCSPKDFKKYFLTFAIERENATDYKHCLITKNENGEYNLSGTKRSFGNLKDLLTCYQTETVRSDSIIFQFIKCCPPKPKDKSNLLVFRSNSVSDVPSSPTLQRHNVSQMVFHKIRNEDLIFEESLGQGTFTKIFKGIRKEVGDYGQLHQTEVLLKVLDKVHRNYSESFFEAASMMSQLSYKHLVLNYGVCVCGEENILVQEYVKFGSLDTYLKKNKNVINILWKLEVAKQLALAMHFLEDKGLVHGNVCAKNILLIREEDRKSGNLPFIKLSDPGISITVLPRDILLERIPWVPPECIENPRQLSLATDKWSFGTTLWEICSGGDKPLSALDSSRKLQFYEDRHQLPAPNWTELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNIRTGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYASQICKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYAIMKECWNNNVAQRPTFRDLAQRVDQIRDNMGG

Annotated regions:
phrase: LIFEESLGQGTFTKIFKGIRKEVGDYGQLHQTEVLLKVLDKVHRNYSESFFEAASMMSQLSYKHLVLNYGVCVCGEENILVQEYVKFGSLDTYLKKNKNVINILWKLEVAKQLALAMHFLEDKGLVHGNVCAKNILLIREEDRKSGNLPFIKLSDPGISITVLPRDILLERIPWVPPECIENPRQLSLATDKWSFGTTLWEICSGGDKPLSALDSSRKLQFYEDRHQLPAPNWTELANLINNCMDYEPDFRPSFRAIIRDL
type: DOMAIN
name: PTK_Jak2_rpt1
description: Janus kinase 2, pseudokinase domain

phrase: YSEVFEVKEPGGDPSGEESFATIVITGNGGIQCSRGKLKNCETLAEQDLQTYCDFPDIIDVSIKQASQEGSSERRIVTIHKQDSKNLEAEFQSLREALSFVSLIDGYYRLTADAHHYLCK
type: DOMAIN
name: JAK2_FERM_C-lobe
description: JAK2, FERM domain C-lobe

phrase: QSNCHGPIFMDFAINKLKKAGNQTGFYVLRCSPKDFKKYFLTFAIERENATDYKHCLITKNENGEYNLSGTKRSFGNLKDLLTCYQTETV
type: DOMAIN
name: SH2
description: SH2 domain

phrase: LGKGNFGSVEMCRYDPLQDNTGEVVAVK
type: BINDING_SITE
name: Protein_kinase_ATP_BS
description: Protein kinase, ATP binding site

phrase: PLLQVYLYYSPGKTGGDYLQFPAGEYVAEEICIVACKACGIMPVYHNMFALMSETERVWYPPNHIFHVDEATRLKLLYRIRFYFPHWYCNGTSRACRYGIIRGSESPVLDDLVMSYLFAQWRKDFLDGWIQMPVTHETQEECLGMAVLDMMRVAKEKDQTPLAVYNSVSYKMFLPKCVRAKIQEYHILTRKRIRYRFRKFIQQFGQCKATARNLKLKYLINLETLQSAFYSEVFEVKEPGGDPSGEESFATIVITGNGGIQCSRGKLKNCETLAEQDLQTYCDFPDIIDVSIKQASQEGSSERRIVTIHKQDSKNLEAEFQSLREALSFVSLIDGYYRLTADA
type: DOMAIN
name: FERM_domain
description: FERM domain

phrase: NCHGPIFMDFAINKLKKAGNQTGFYVLRCSPKDFKKYFLTFAIERENATDYKHCLITKNENGEYNLSGTKRSFGNLKDLLTCYQTETVRSDSIIFQFIKCCP
type: DOMAIN
name: SH2
description: SH2 domain

phrase: HGPIFMDFAINKLKKAGNQTGFYVLRCSPKDFKKYFLTFAIERENATDYKHCLITKNENGEYNLSGTKRSFGNLKDLLTCY
type: DOMAIN
name: SH2
description: SH2 domain

phrase: LIFEESLGQGTFTKIFKGIRKEVGDYGQLHQTEVLLKVLDKVHRNYSESFFEAASMMSQLSYKHLVLNYGVCVCGEENILVQEYVKFGSLDTYLKKNKNVINILWKLEVAKQLALAMHFLEDKGLVHGNVCAKNILLIREEDRKSGNLPFIKLSDPGISITVLPRDILLERIPWVPPECIENPRQLSLATDKWSFGTTLWEICSGGDKPLSALDSSRKLQFYEDRHQLPAPNWTELANLINNCMDYEPDFRPSFRAIIRD
type: DOMAIN
name: Tyr_kinase_cat_dom
description: Tyrosine-protein kinase, catalytic domain

phrase: LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYASQICKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYAIMKECWNNNVAQRPTFRDLAQR
type: DOMAIN
name: Tyr_kinase_cat_dom
description: Tyrosine-protein kinase, catalytic domain

phrase: YLFAQWRKDFLDGWIQMPVTHETQEECLGMAVLDMMRVAKEKDQTPLAVYNSVSYKMFLPKCVRAKIQEYHILTRKRIRYRFRKFIQQFGQCKATARNLKLKYLINLET
type: DOMAIN
name: FERM_central
description: FERM central domain

phrase: LIFEESLGQGTFTKIFKGIRKEVGDYGQLHQTEVLLKVLDKVHRNYSESFFEAASMMSQLSYKHLVLNYGVCVCGEENILVQEYVKFGSLDTYLKKNKNVINILWKLEVAKQLALAMHFLEDKGLVHGNVCAKNILLIREEDRKSGNLPFIKLSDPGISITVLPRDILLERIPWVPPECIENPRQLSLATDKWSFGTTLWEICSGGDKPLSALDSSRKLQFYEDRHQLPAPNWTELANLINNCMDYEPDFRPSFRAIIRDLNSL
type: DOMAIN
name: Prot_kinase_dom
description: Protein kinase domain

phrase: KQTEPLLQVYLYYSPGKTGGDYLQFPAGEYVAEEICIVACKACGIMPVYHNMFALMSETERVWYPPNHIFHVDEATRLKLLYRIRFYFPHWYCNGTSRACRYGIIRGSESPVLDDLVMSYLFAQWRKDFLDGWIQMPVTHETQEECLGMAVLDMMRVAKEKDQTPLAVYNSVSYKMFLPKCVRAKIQEYHILTRKRIRYRFRKFIQQFGQCKATARNLKLKYLINLETLQSAFYSEV
type: DOMAIN
name: Band_41_domain
description: Band 4.1 domain

phrase: LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYASQICKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYAIMKECWNNNVAQRPTFRDLAQRVDQ
type: DOMAIN
name: Prot_kinase_dom
description: Protein kinase domain

phrase: LQVYLYYSPGKTGGDYLQFPAGEYVAEEICIVACKACGIMPVYHNMFALMSETERVWYPPNHIFHVDEATRLKLLYRIRFYFPHWYCNGTSRACR
type: DOMAIN
name: FERM_F1
description: FERM F1 lobe ubiquitin-like domain

phrase: EVAPPSVLENIQSNCHGPIFMDFAINKLKKAGNQTGFYVLRCSPKDFKKYFLTFAIERENATDYKHCLITKNENGEYNLSGTKRSFGNLKDLLTCY
type: DOMAIN
name: JAK2_SH2
description: Tyrosine-protein kinase JAK2, SH2 domain

phrase: FEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYASQICKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYAIMKECWNNNVAQRPTFRDLAQRVDQI
type: DOMAIN
name: PTKc_Jak2_rpt2
description: Janus kinase 2, catalytic domain

phrase: YVHRDLATRNIL
type: ACTIVE_SITE
name: Tyr_kinase_AS
description: Tyrosine-protein kinase, active site

phrase: IFEESLGQGTFTKIFKGIRKEVGDYGQLHQTEVLLKVLDKVHRNYSESFFEAASMMSQLSYKHLVLNYGVCVCGEENILVQEYVKFGSLDTYLKKNKNVINILWKLEVAKQLALAMHFLEDKGLVHGNVCAKNILLIREEDRKSGNLPFIKLSDPGISITVLPRDILLERIPWVPPECIENPRQLSLATDKWSFGTTLWEICSGGDKPLSALDSSRKLQFYEDRHQLPAPNWTELANLINNCMDYEPDFRPSFRAIIRD
type: DOMAIN
name: Ser-Thr/Tyr_kinase_cat_dom
description: Serine-threonine/tyrosine-protein kinase, catalytic domain

phrase: LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYASQICKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYAIMKECWNNNVAQRPTFRDLAQ
type: DOMAIN
name: Ser-Thr/Tyr_kinase_cat_dom
description: Serine-threonine/tyrosine-protein kinase, catalytic domain

phrase: SPVLDDLVMSYLFAQWRKDFLDGWIQMPVTHETQEECLGMAVLDMMRVAKEKDQTPLAVYNSVSYKMFLPKCVRAKIQEYHILTRKRIRYRFRKFIQQFGQCKATARNLKLKYLINLET
type: DOMAIN
name: FERM_F2
description: JAK, FERM F2 lobe domain

phrase: ETLAEQDLQTYCDFPDIIDVSIKQASQEGSSERRIVTIHKQDSKNLEAEFQSLREALSFVSLIDGYYRLTADAH
type: DOMAIN
name: JAK1-3/TYK2_PHL_dom
description: JAK1-3/TYK2, pleckstrin homology-like domain

phrase: MEYLPYGSLRDYL
type: DOMAIN
name: Ser-Thr/Tyr_kinase_cat_dom
description: Serine-threonine/tyrosine-protein kinase, catalytic domain

phrase: YLGTKRYVHRDLATRNIL
type: DOMAIN
name: Ser-Thr/Tyr_kinase_cat_dom
description: Serine-threonine/tyrosine-protein kinase, catalytic domain

phrase: SPIFWYAPES
type: DOMAIN
name: Ser-Thr/Tyr_kinase_cat_dom
description: Serine-threonine/tyrosine-protein kinase, catalytic domain

phrase: SDVWSFGVVLYELFTYIEKSKS
type: DOMAIN
name: Ser-Thr/Tyr_kinase_cat_dom
description: Serine-threonine/tyrosine-protein kinase, catalytic domain