Protein sequence:
MSKSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPKNATQAQSAVDFLQHADYVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIANGEKNWKTELNQFFKDFSQQLSQAELDELEGGMKPNSLVPTDINCPTCGRKMAIRTASTGVFLGCSGYALPPKERCKTTMNLIPEAELLNVLDEASETKALMERKRCPKCGTAMDSYLIDPERKIHICGHNPNCDGYVLEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMGCTSCDNTRKILKSGEVAPPKEEPTHFPELKCEK

Annotated regions:
phrase: QRLYEAGYITYMRT
type: ACTIVE_SITE
name: Topo_IA_AS
description: DNA topoisomerase, type IA, active site

phrase: KSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDD
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: DRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPKNATQAQSAVDFLQHADYVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIANGEKNWKTELNQFFKDFSQQ
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: INCPTCGRKMAIRTASTGVFLGCSG
type: DOMAIN
name: Topo_IA_Znf
description: DNA topoisomerase, type IA, zn finger

phrase: VECDKCGADMHLKLGRFGKYMGCTSCDNTRKIL
type: DOMAIN
name: Topo_IA_Znf
description: DNA topoisomerase, type IA, zn finger

phrase: LVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNE
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain

phrase: ETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIV
type: DOMAIN
name: Topo_IA_DNA-bd_dom
description: DNA topoisomerase, type IA, DNA-binding domain

phrase: ETKALMERKRCPKCGTAMDSYLIDPERKIHICGHNPNCDGYVL
type: DOMAIN
name: TOP1_Znf
description: Topoisomerase I, zinc finger

phrase: KSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFEK
type: DOMAIN
name: TOPRIM_TopoI
description: DNA topoisomerase 1, TOPRIM domain

phrase: NLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPKNATQAQSAVDFLQHADYVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIANGEKNWK
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LYDLIWRQFVACQMPA
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: GIGRPSTYAAIIST
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: AGYITYMRT
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: LSAGRVQSVAVKLVVERE
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: IYLATDLDREGEA
type: DOMAIN
name: Topo_IA_cen
description: DNA topoisomerase, type IA, central

phrase: RFSRVVFNEITKNAIQQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYW
type: DOMAIN
name: Topo_IA_2
description: DNA topoisomerase, type IA, domain 2

phrase: KSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNE
type: DOMAIN
name: TOPRIM_dom
description: TOPRIM domain