Query: Norepinephrine: Material-independant, multifunctional surface modification reagent

Candidate papers:

abstract: A facile approach for material independent surface modification using norepinephrine was investigated. pH induced oxidative polymerization of norepinephrine forms adherent films on vastly different types of material surfaces of noble metals, metal oxides, semiconductors, ceramics, shape memory alloys, and synthetic polymers. Secondary biochemical functionalizations such as immobilization of proteins and growth of biodegradable polyester on the poly(norepinephrine) films were demonstrated.
author_names: Sung Min Kang

Junsung Rho

Insung S Choi

Phillip B Messersmith

Haeshin Lee
title: Norepinephrine: material independent, multifunctional surface modification reagent.
venue: Journal of the American Chemical Society
year: 2009

abstract: Dopamine surface chemistry has been of great interest because of its universal coating property and ability to transform nonadhesive molecules into adhesive molecules. Catechol oxidation and intramolecular cyclization underlie the unique property of dopamine (DA) surface chemistry and provide clues for developing new surface modification reagents such as norepinephrine, 5 pyrogallol 2 aminoethane, and perfluorinated DA derivatives. Based on these inspiring properties, a fast and universal surface chemistry technique using 4 (3 aminopropyl) benzene 1,2 diol (3 catecholpropanamine, CPA) is reported herein. A single carbon insertion in the aliphatic chain of DA gives rise to the significantly accelerated intermolecular assembly and surface coating of CPA. The effect of CPA conjugation on an anticoagulant polysaccharide coating is also investigated. The use of CPA instead of DA to make polysaccharide coating materials improves the coating rate, while maintaining excellent antiplatelet performance on the coated surface.
author_names: Jeongwoo Hong

Dong Gyun Jwa

Hyeonbin Ha

Jaesung Kwak

Min Kim

Sung Min Kang
title: 4 (3 Aminopropyl) benzene 1,2 diol: An Improved Material Independent Surface Coating Reagent Compared to Dopamine.
venue: Langmuir the ACS journal of surfaces and colloids
year: 2019

abstract: Polymers are commonly used materials for microfluidic chip fabrication, because they are standardized in fabrication and low in cost. However, most polymeric materials that are readily fabricated on the industrial scale are hydrophobic, which is inconvenient for the injection and flow of the aqueous solution, resulting in poor analytical performance for biochemical assays. In this work, we present a straightforward and ultrastable surface modification process for polymeric chips. A one step modification by using norepinephrine bitartrate monohydrate as a modification reagent is completed at room temperature. The hydrophilicity of the polymeric surfaces increases dramatically. Surface modification is stable for at least 2.5 years, allowing for autoinjection of aqueous solution into the channels. The chips are applied in the immunoassay of alpha fetoprotein (AFP) The low nonspecific adsorption after modification results in significantly decreased background noise, optimized signal to noise ratios (SNR) and dramatically enhanced reproducibility of the immunoassay. Thirty clinical human serum samples are analyzed; these results strongly correlated with the values obtained using commercial test kits. We anticipate that this surface modification method can be used for immunoassay devices in analytical and biosensing technology.
author_names: Haiying Shen

Feng Qu

Yong Xia

Xingyu Jiang
title: Straightforward and Ultrastable Surface Modification of Microfluidic Chips with Norepinephrine Bitartrate Improves Performance in Immunoassays.
venue: Analytical chemistry
year: 2018

abstract: 3,616,229 10/1971 Wildli et al. 196/63 3,959,078 5/1976 Guire 195/63 4,722,906 2/1988 Guire 435/4 4,973,493 11/1990 Guire 427/2 4,979,959 12/1990 Guire 623/66 5,002,582 3/1991 Guire et al. 623/66 5,258,041 11/1993 Guire et al. 623/66 5,414,075 5/1995 Swan et al. 568/333 5,512,329 4/1996 Guire et al. 427/508
author_names: Dale G Swan

Louis Park

Charles A Hastings
title: United States Patent 19 Swan et al 54 RESTRAINED MULTIFUNCTIONAL REAGENT FOR SURFACE MODIFICATION
year: 2017

abstract: Various micro surface modification approaches including photolithography, dip pen lithography and ink jet systems have been developed and used to extend the functionalities of solid surfaces. While those approaches work in the "open space" push pull systems which work in solutions have recently drawn considerable attention. However, the confining flows performed by push pull systems have realized only the dispense process, while microscale, region selective chemical reactions have remained unattainable. This study reports a microchemical pen that enables region selective chemical reactions for the micro surface modification/patterning. The chemical pen is based on the principle of microfluidic laminar flows and the resulting mixing of reagents by the mutual diffusion. The tiny diffusion layer performs as the working region. This report represents the first demonstration of an open microreactor in which two different reagents react on a real solid sample. The multifunctional characteristics of the microchemical pen are confirmed by different types of reactions in many research areas, including inorganic chemistry, polymer science, electrochemistry and biological sample treatment.
author_names: Sifeng Mao

Chiho Sato

Yuma Suzuki

Jianmin Yang

Hulie Zeng

Hizuru Nakajima

Ming Yang

Jin-Ming Lin

Katsumi Uchiyama
title: Microchemical Pen: An Open Microreactor for Region Selective Surface Modification.
venue: Chemphyschem a European journal of chemical physics and physical chemistry
year: 2016

abstract: As a result of their extraordinarily large surfaces and well defined pores, the design of a multifunctional metal organic framework (MOF) is crucial for drug delivery but has rarely been reported. In this paper, a novel drug delivery system (DDS) based on nanoscale MOF was developed for use in cancer diagnosis and therapy. This MOF based tumor targeting DDS was fabricated by a simple postsynthetic surface modification process. First, magnetic mesoporous nanomaterial Fe MIL 53 NH2 was used for encapsulating the drug and served as a magnetic resonance contrast agent. Moreover, the Fe MIL 53 NH2 nanomaterial exhibited a high loading capacity for the model anticancer drug 5 fluorouracil (5 FU) Subsequently, the fluorescence imaging agent 5 carboxyfluorescein (5 FAM) and the targeting reagent folic acid (FA) were conjugated to the 5 FU loaded Fe MIL 53 NH2, resulting in the advanced DDS Fe MIL 53 NH2 FA 5 FAM/5 FU. Owing to the multifunctional surface modification, the obtained DDS Fe MIL 53 NH2 FA 5 FAM/5 FU shows good biocompatibility, tumor enhanced cellular uptake, strong cancer cell growth inhibitory effect, excellent fluorescence imaging, and outstanding magnetic resonance imaging capability. Taken together, this study integrates diagnostic and treatment aspects into a single platform by a simple and efficient strategy, aiming for facilitating new possibilities for MOF use for multifunctional drug delivery.
author_names: Xuechuan Gao

Ma-Yue Zhai

Weihua Guan

Jingjuan Liu

Zhiliang Liu

Alatangaole Damirin
title: Controllable Synthesis of a Smart Multifunctional Nanoscale Metal Organic Framework for Magnetic Resonance/Optical Imaging and Targeted Drug Delivery.
venue: ACS applied materials interfaces
year: 2017

abstract: Green chemistry, in particular, the principle of atom economy, has defined new criteria for the efficient and sustainable production of synthetic compounds. In complex nanomaterials, the number of embedded functional entities and the energy expenditure of the assembly process represent additional compound associated parameters that can be evaluated from an economic viewpoint. In this Perspective, we extend the principle of atom economy to the study and characterization of multifunctionality in nanocarriers, which we define as "multifunctional efficiency" This concept focuses on the design of highly active nanomaterials by maximizing integrated functional building units while minimizing inactive components. Furthermore, synthetic strategies aim to minimize the number of steps and unique reagents required to make multifunctional nanocarriers. The ultimate goal is to synthesize a nanocarrier that is highly specialized but practical and simple to make. Owing to straightforward crystal engineering, metal organic framework (MOF) nanoparticles are an excellent example to illustrate the idea behind this concept and have the potential to emerge as next generation drug delivery systems. Here, we highlight examples showing how the combination of the properties of MOFs e.g. their organic inorganic hybrid nature, high surface area, and biodegradability) and induced systematic modifications and functionalizations of the MOF's scaffold itself lead to a nanocarrier with high multifunctional efficiency.
author_names: Ralph Freund

Ulrich Lachelt

Tobias Gruber

Bastian Ruhle

Stefan Wuttke
title: Multifunctional Efficiency: Extending the Concept of Atom Economy to Functional Nanomaterials.
venue: ACS nano
year: 2018

abstract: A systematic investigation into the influence of the degree of fluorination on the static and dynamic wetting behavior of TiO2 based nanobelt (TNB) particles with various liquids is described. The effect of the degree of fluorination and the surface tension of the liquid on the occurrence and stability of liquid marbles, foams or dispersions are studied and the wetting behavior and arrangement of particles at the air liquid surface are observed. Using contact angle (th) measurements, the relation between the type of particle stabilized material and th is established. For liquids of relatively high tension like water or formamide which do not wet the fluorinated particles, a powder like material (marble) is formed. For polar oils of intermediate tension (35 50 mN m 1) which partially wet the fluorinated particles, stable air in oil foams can be prepared in which particles form a close packed layer enveloping air bubbles. Liquids of relatively low tension, e.g. ethanol or polydimethylsiloxane, wet the particles forming a uniform dispersion and partial sedimentation. By contrast, the as prepared hydrophilic TNB particles are rapidly wetted by all the liquids as expected due to their high surface energy. The stable cross stacked TNB particles with fluoroalkylsilane (FAS) modification could be a versatile platform in a wide range of applications, especially for fluidic devices (e.g. biofluids, gas sensing, and lab on a chip devices) In a proof of concept study, the oil water separation performance of fabrics with chemically stable TNB/FAS coating and the liquid isolation by a TNB/FAS shell for highly sensitive gas sensing or reagent assays are investigated.
author_names: Yuekun Lai

Huanfu Zhou

Zheng Zhang

Yuxin Tang

Jeffrey Weng Chye Ho

Jianying Huang

Qiuling Tay

Ke-Qin Zhang

Zhiling Chen

Bernard P Binks
title: Multifunctional TiO2 Based Particles: The Effect of Fluorination Degree and Liquid Surface Tension on Wetting Behavior
year: 2015

abstract: Recently, metal organic gels (MOGs) appear as a potential alternative to the well known metal organic frameworks due to the easier and more straightforward shaping and other unique features. However, the modification of MOGs with noble metal nanoparticles is still in its infancy. On the other hand, developing multifunctional SERS substrate materials with a facile way still remains a great challenge. Herein, silver nanoparticles/metal organic gels (AgNPs/MOGs) hybrid, a novel dual functional SERS active platform that is both Raman signal molecule and highly sensitive SERS substrate, was fabricated by a one pot approach for the first time. The AgNPs/MOGs hybrid, which was obtained by simply mixing 4 (2,2':6',2' terpyridine) 4' ylbenzoic acid (Hcptpy) and silver ion (Ag+ followed by heating without adding extra reducing reagent, exhibited an outstanding Raman signal due to the combination of the Raman label source of Hcptpy and the localized surface plasmon resonance properties of AgNPs, endowing it an exc.
author_names: Yang Li

Mao Xia Guo

Li He

Cheng Zhi Huang

Yuan Fang Li
title: Green One Pot Synthesis of Silver Nanoparticles/Metal Organic Gels Hybrid and Its Promising SERS Application
year: 2019

abstract: Abstract We report a method for preparing chemically stable catecholamine coatings on solid substrates. The catecholamine, norepinephrine, was used as a surface modification reagent, forming a coating of poly(norepinephrine) under alkaline conditions. The stability of the polymer layer was enhanced by using a post oxidation treatment, and the resulting surface showed superior stability in the presence of a strong acid or a harsh organic solvent.
author_names: Yooil Jeon

Sung Min Kang
title: Chemically stable poly(norepinephrine) coatings on solid substrates by post oxidation
year: 2013