Query: Study of the effect of the stress on CdTe nuclear detectors

Candidate papers:

abstract: CdTe detectors are commonly used for X and g ray applications. The performance of these detectors is strongly affected by different types of mechanical stress; such as that caused by differential expansion between the semiconductor and its intimate metallic contacts and that caused by applied pressure during the bonding process. The aim of this work was to study the effects of stress on the performance of CdTe detectors. A difference in expansion coefficients induces transverse stress under the metallic contact, while contact pressure induces longitudinal stress. These stresses have been simulated by applying known static pressures. For the longitudinal case, the pressure was applied directly to the metallic contact; while in the transverse case, it was applied to the side. We have studied the effect of longitudinal and transverse stresses on the electrical characteristics including leakage current measurements and g ray detection performance. We have also investigated induced defects, their nature, activation energies, cross sections, and concentrations under the applied stress by using photo induced current transient spectroscopy and thermoelectric effect spectroscopy techniques. The operational stress limit is also given.
author_names: M Ayoub

M Hage-ali

Ian Radley

John T Mullins
title: Study of the effect of the stress on CdTe nuclear detectors
year: 2013

abstract: Objective: Pentoxifylline has previously been shown to increase haemoglobin levels in patients with chronic kidney disease (CKD) and erythropoietin stimulating agent (ESA) hyporesponsive anaemia in the HERO multi centre double blind, randomized controlled trial. The present study evaluated the effects of pentoxifylline on oxidative stress in ESA hyporesponsive CKD patients. Methods: This sub study of the HERO trial compared 15 patients in the pentoxifylline arm (400 mg daily) and 17 in the matched placebo arm on oxidative stress markers: plasma total F2 isoprostanes, protein carbonyls, glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities. Results: Pentoxifylline did not significantly alter total F2 isoprostanes (adjusted mean difference (MD) 35.01 pg/ml, P 0.11) SOD activity (MD 0.82 U/ml, P 0.07) GPX activity (MD 6.06 U/l, P 0.09) or protein carbonyls (MD 0.04 nmol/mg, P 0.52) Replicating results from the main study, pentoxifylline significantly increased haemoglobin concentration compared with controls (MD 7.2 g/l, P 0.04) Conclusions: Pentoxifylline did not alter oxidative stress biomarkers, suggesting that alternative mechanisms may be responsible for the agent's ability to augment haemoglobin levels in CKD patients with ESA hyporesponsive anaemia.
author_names: Lei Zhang

Jeff S Coombes

Elaine M Pascoe

Sunil V Badve

Kim Dalziel

Alan Cass

Philip Clarke

Paolo Ferrari

Stephen P McDonald

Alicia T Morrish

Eugenie Pedagogos

Vlado Perkovic

Donna Reidlinger

Anish Scaria

Rowan G Walker

Liza A Vergara

Carmel M Hawley

David W Johnson
title: The effect of pentoxifylline on oxidative stress in chronic kidney disease patients with erythropoiesis stimulating agent hyporesponsiveness: Sub study of the HERO trial
venue: Redox report communications in free radical research
year: 2016

abstract: Cardiovascular disease (CVD) and mental distress have been suggested to be associated with post traumatic stress disorder (PTSD) but the effect of their combination on PTSD is unknown. We reviewed the synergistic effects of the history of CVD and mental distress on the possibility of PTSD among residents in Fukushima after the Great East Japan Earthquake. This cross sectional study was conducted among 38,392 participants aged 40 74 years in the evacuation area who applied for the Fukushima Health Management Study in Fiscal Year 2011. Relative excess risk due to interaction (RERI) attributable proportion (AP) odds ratio (OR) and 95% confidence interval (CI) were calculated to investigate the combined effect of history of CVD and mental distress on PTSD. We identified 8104 probable cases of PTSD (21.1% History of CVD, mental distress, and their combination were positively associated with probable PTSD: the multivariable ORs (95% CIs) were 1.44 (1.04, 2.01) 20.08 (18.14, 22.22) and 26.60 (23.07, 30.67) respectively. There was a significant increase in RERI: the corresponding RERI (95% CI) and AP were 6.08 (3.16, 9.00) and 22.9% Gender specific analyses showed similar associations. Thus, we found a supra additive association of history of CVD and mental distress with probable PTSD after the disaster.
author_names: Kazuhide Tezuka

Tetsuya Ohira

Hirooki Yabe

Seiji Yasumura

Mayumi Harigane

Masahiko Kiyama
title: Synergistic Effect of History of Cardiovascular Disease and Mental Distress on Post Traumatic Stress Disorder after the Great East Japan Earthquake: The Fukushima Health Management Survey
venue: International journal of environmental research and public health
year: 2021

abstract: Allergic rhinitis (AR) a common chronic disease, impairs patients' quality of life (QoL) This study aimed to determine the effect of perceived stress on disease related QoL in AR patients. There were 741 patients from eight medical centers of the Allergic Rhinitis Cohort (ARCO) study. Data on sociodemographics, chronic conditions, AR severity, perceived stress level and Rhinoconjunctivitis QoL Questionnaire (RQLQ) results, and laboratory test findings were collected. The relationship between perceived stress and total RQLQ was analyzed using multiple linear regression. Potential confounding variables were adjusted. A high perceived stress level was associated with a high total RQLQ, which reflected worsening disease related QoL. The high stress level was associated with an increased total RQLQ of 1.210 (95% confidence interval, 0.831 1.589; p 0.0001) compared with the very low level. In the final model, the multiple regression adjusted R2 for RQLQ in AR participants was 0.5279, and perceived stress levels contributed 4.08% in additional explanatory power to RQLQ in AR patients. In conclusion, perceived stress is a potentially modifiable risk factor for decreased disease related QoL in patients with AR, which may be improved with stress management.
author_names: Il Gyu Kong

Chae-Seo Rhee

Hyo Jin Yim
title: Association between Perceived Stress and Rhinitis Related Quality of Life: A Multicenter, Cross Sectional Study
venue: Journal of clinical medicine
year: 2021

abstract: Globally the COVID 19 pandemic outbreak has triggered an economic downturn and a rise in unemployment. As a result, global communities have had to face physical, health, psychological and socio economical related stressors. The purpose of this study was to assess and report the impact of isolation and effect of coronavirus on selected psychological correlates associated with emotions. Following ethical approval, a mixed methods observational study was conducted using the validated COVISTRESS questionnaire. Two observational study scenarios were evaluated namely "Prior" to the COVID 19 outbreak and "Currently" i.e. during the COVID 19 pandemic. 10,121 participants from 67 countries completed the COVISTRESS questionnaire. From the questionnaire responses only questions that covered the participant's occupation; sociodemographic details, isolation and impact of coronavirus were selected. Further analyses were performed on output measures that included leisure time, physical activity, sedentary time and emotions. All output measures were evaluated using the Visual Analogue Scale (VAS) with an intensity ranging from 0 100. Descriptive statistics, Wilcoxon signed rank test and Spearman correlational analysis were applied to the leisure time, physical activity, sedentary time and emotional feeling datasets; p 0.05 was set as the significance level. Both males and females displayed similar output measures. The Wilcoxon signed rank test showed significant differences with respect to "Prior" COVID 19 and "Currently" for sedentary activity (Z 40.462, p 0.001) physical activity (Z 30.751, p 0.001) and all other emotional feeling output measures. A moderate correlation between "Prior" COVID 19 and "Currently" was observed among the Males (r 0.720) in comparison to the Females (r 0.639) for sedentary activity while weaker correlations (r 0.253) were observed for physical activity and emotional feeling measurements, respectively. Our study reported incremental differences in the physical and psychological output measures reported, i.e. "Prior" COVID 19 and "Currently" "Prior" COVID 19 and "Currently" participants increased their sedentary habits by 2.98% and the level of physical activity reduced by 2.42% depression levels increased by 21.62% anxiety levels increased by 16.71% and stress levels increased by 21.8% There were no correlations (r) between leisure, physical activity and sedentary action (i.e. "Prior" 0.071; "Currently" 0.097) no correlations (r) between leisure physical activity and emotion (i.e. 0.071 r 0.081) for "Prior" and poor correlations (r) between leisure, physical activity and sedentary action (i.e. 0.078 r 0.167) for "Current" The correlations (r) between sedentary action and emotion for "Prior" and "Currently" were 0.100 r 0.075) and 0.040 r 0.041) respectively. The findings presented here indicate that the COVISTRESS project has created awareness in relation to the physical and psychological impact resulting from the COVID 19 pandemic. The findings have also highlighted individual distress caused by COVID 19 and associated health consequences for the global community.
author_names: Ukadike Chris Ugbolue

Martine Duclos

Constanta Urzeala

Mickael Berthon

Keri S Kulik

Aura Bota

David Thivel

Reza Bagheri

Yaodong Gu

Julien Steven Baker

Nicolas Andant

Bruno Pereira

Karine Rouffiac

Maelys Clinchamps

Frederic Dutheil
title: An Assessment of the Novel COVISTRESS Questionnaire: COVID 19 Impact on Physical Activity, Sedentary Action and Psychological Emotion
venue: Journal of clinical medicine
year: 2020

abstract: One of the uncertainties in the interpretation of ultrahigh energy cosmic ray data comes from the hadronic interaction models used for air shower Monte Carlo (MC) simulations. The number of muons observed at the ground from ultrahigh energy cosmic ray induced air showers is expected to depend upon the hadronic interaction model. One may therefore test the hadronic interaction models by comparing the measured number of muons with the MC prediction. In this paper, we present the results of studies of muon densities in ultrahigh energy extensive air showers obtained by analyzing the signal of surface detector stations which should have high muon purity. The muon purity of a station will depend on both the inclination of the shower and the relative position of the station. In seven years' data from the Telescope Array experiment, we find that the number of particles observed for signals with an expected muon purity of ~65% at a lateral distance of 2000 m from the shower core is 1.72+ 0.10(stat) 0.37(syst) times larger than the MC prediction value using the QGSJET II 03 model for proton induced showers. A similar effect is also seen in comparisons with other hadronic models such as QGSJET II 04, which shows a 1.67+ 0.10+ 0.36 excess. We also studied the dependence of these excesses on lateral distances and found a slower decrease of the lateral distribution of muons in the data as compared to the MC, causing larger discrepancy at larger lateral distances.
author_names: Telescope Array Collaboration R U Abbasi

Masashi Abe

T Abu-Zayyad

Monica Allen

R Azuma

Elliott Barcikowski

J W Belz

D R Bergman

Stephen Blake

Robert Cady

Byung Gu Cheon

Junsei Chiba

Michiyuki Chikawa

A di Matteo

T Fujii

Kazuhisa Fujita

M Asaki Fukushima

G Furlich

T Goto

W Hanlon

Motoki Hayashi

Yoshitsugu Hayashi

N Hayashida

K Hibino

Ken Honda

D Ikeda

Nobutaka Inoue

T Ishii

R Ishimori

H Ito

D Ivanov

Hyun Mook Jeong

S M Jeong

Charles C H Jui

K Kadota

Fumio Kakimoto

Oleg E Kalashev

Kota Kasahara

Hisashi Kawai

S Kawakami

Shingo Kawana

K Kawata

E Kido

H B Kim

Joon Hyun Kim

Shunsuke Kishigami

S Kitamura

Yoshiyuki Kitamura

Valentin Kuzmin

M Kuznetsov

Y -J Kwon

Kuan Huang Lee

Bayarto Lubsandorzhiev

J P Lundquist

Koji Machida

Kalen Martens

T Matsuyama

J N Matthews

Rosa Mayta

Mayuko Minamino

K Mukai

Isaac Myers

Kazuya Nagasawa

Shigehiro Nagataki

R Nakamura

Toru M Nakamura

T Nonaka

Hiroshi Oda

Shoichi Ogio

J Ogura

Munehiro Ohnishi

Hideyuki Ohoka

Takeshi Okuda

Yasuhisa Omura

Masaomi Ono

Ryota Onogi

Akitoshi Oshima

Shunsuke Ozawa

Il Han Park

M S Pshirkov

J Remington

Diego Rodriguez

G I Rubtsov

D Ryu

Hiroyuki Sagawa

Ryosuke Sahara

K Saito

Y Saito

Nobuhiro Sakaki

Nobuyuki Sakurai

Lauren M Scott

Tetsuo Seki

Koichi Sekino

P D Shah

Fumiya Shibata

Tatsuo Shibata

Hideaki Shimodaira

Bok Kyun Shin

H S Shin

J Torquil Smith

P Sokolsky

Bradford T Stokes

Sean R Stratton

Thomas Stroman

Takumi Suzawa

Yukinori Takagi

Y H Takahashi

Mitsuko Takamura

Masahiro Takeda

Ryuji Takeishi

Akimichi Taketa

Masatoshi Takita

Y Tameda

H Tanaka

K H Tanaka

M Tanaka

S B Thomas

Gordon Bennett Thomson

P Tinyakov

Igor Tkachev

Hisao Tokuno

Takayuki Tomida

S V Troitsky

Yoshiki Tsunesada

Katsuya Tsutsumi

Yukio Uchihori

Shigeharu Udo

Federico R Urban

T Wong

M Yamamoto

R Yamane

Hiroshi Yamaoka

Kanako Yamazaki

Jinghui Yang

Kurato Yashiro

Yuichi Yoneda

Shigeru Yoshida

Hisashi Yoshii

Ya V Zhezher

Z Zundel High Energy Astrophysics Institute

Department of Engineering Physics

University of Utah

Salt lake City

The Barcelona Institute of Science

Saitama University

Graduate School of Science

Tokyo Institute of Technology

Hanyang University

Tokyo University of Science

Kindai University

Higashi Osaka

Service de Physique Th'eorique

Universit'e libre de Bruxelles

Inst for Nucl Research

University of Tokyo

Osaka City University

Kavli Institute for the Physics

Mathematics of the Universe

Todai Institutes for Advanced Study

Information Science

Shinshu University

Faculty of Electrical Engineering

Kanagawa University

Interdisciplinary Graduate School of Medicine

University of Yamanashi

Astrophysical Big Bang Laboratory

Sun Yat-sen University

Tokyo City University

Institute for Nuclear Research of the Russian Academy of Sciences

Advanced Research Institute for Science

Waseda University

Chiba University

School of Physical Sciences

Ulsan National Institute of Science

Yonsei University

A Misaki Graduate School of Science

Technology Institute of Engineering

Faculty of Computer Science

Kochi University

Department of Astrophysical Sciences

Ritsumeikan University

Sternberg Astronomical Institute

Moscow state University

Rutgers University - The State University of New Jersey

New Jersey

Earthquake Research Institute

Department of Materials Science

Osaka Electro-Communication University

Graduate School of Sciences

Hiroshima City University

Institute of Particle

Nuclear Studies

National Institute for Materials Science

Institute of Metal Physics

Czech Academy of Sciences

Czech Republic

Institute for Fundamental Physics of the Universe

Ewha Womans University

Ehime University
title: Study of muons from ultrahigh energy cosmic ray air showers measured with the Telescope Array experiment
year: 2018

abstract: Elevated cerebrospinal fluid (CSF) levels of markers of oxidative stress, neuronal injury, and inflammation and decreased neurotransmitter levels have been reported in HIV associated neurocognitive disorders (HAND) Minocycline may have a neuroprotective effect by inhibiting inducible nitric oxide synthase, which produces nitric oxide, a compound that induces oxygen free radical production. In A5235, "Phase II, Randomized, Placebo Controlled, Double Blind Study of Minocycline in the Treatment of HIV Associated Cognitive Impairment," minocycline was not associated with cognitive improvement, but the effect on the above CSF measures was not examined previously. The objective of this study was to examine the effect of minocycline on markers of oxidative stress, neuronal injury, neurotransmitter levels, and inflammation from CSF in participants in A5235. One hundred seven HIV+ individuals received either minocycline 100 mg or placebo orally every 12 h for 24 weeks. Twenty one HIV+ individuals received the optional lumbar punctures. Lipid and protein markers of oxidative stress (e.g. ceramides and protein carbonyls) glutamate, neurotransmitter precursors, kynurenine metabolites, neurofilament heavy chain, and inflammatory cytokines were measured in the CSF before and after treatment. The 24 week change in ceramides was larger in a beneficial direction in the minocycline group compared to the placebo group. The two groups did not differ in the 24 week changes for other markers.These results suggest that minocycline may decrease lipid markers of oxidative stress (ceramides) in individuals with HAND; however, an effect of minocycline on other CSF markers was not observed. A larger sample size is needed to further validate these results.
author_names: Ned Sacktor

Sachiko Miyahara

Scott R Evans

Giovanni Schifitto

Bruce A Cohen

Norman J Haughey

Julia L Drewes

David R Graham

Mary Christine Zink

Caroline Anderson

Avindra Nath

Carlos A Pardo

Sean McCarthy

Lara Hosey

David B Clifford

on behalf of the Actg A5235 team
title: Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV seropositive individuals with cognitive impairment
venue: Journal of NeuroVirology
year: 2014

abstract: PurposeThis is the second of a series of surveys designed to assess myocardial perfusion scintigraphy (MPS) practice in Europe.MethodsData were collected from 258 centres in 18 countries. The number of MPS studies per million population (pmp) was estimated assuming that the nonresponding centres performed either no studies (lower estimate) or the same number as the responding centres (upper estimate).ResultsThe responding centres served 24% of the population of their countries. The total number of noncardiac nuclear medicine studies was between 2,160 and 8,000 studies pmp. The total number of MPS studies was between 529 and 2,293 pmp. The median number of MPS studies per centre was 571 per year with 57% performing fewer than 500 studies per year and 23% of centres performing fewer than 250 studies per year. There was significant variation between countries, with higher numbers of MPS studies (lower limit of estimate above the mid range of all countries combined) in Austria, Denmark, Hungary, Portugal and Slovenia, and lower numbers (upper limit of estimate below the mid range of all countries) in Finland, Norway, Spain and Switzerland. The ratio of MPS to coronary angiography to revascularization procedures was 0.9 to 2.2 to 1. Pharmacological stress was used in 57% and technetium 99m labelled tracers in 88% of studies. ECG gating was performed in 74% of studies and attenuation correction in 22%.ConclusionMPS utilization in Europe remains low compared with coronary angiography although there has been a 21% increase in the number of studies pmp in centres that reported in both 2005 and 2007. Pharmacological agents continue to be the predominant form of stress. Despite the widespread use of technetium 99m labelled tracers, ECG gating is not universally performed. As in the 2005 survey, imaging aids such as attenuation and motion correction and prone imaging are not commonly used.
author_names: Eliana M Reyes

Susanna Wiener

Stephen Richard Underwood

on behalf of the European Council of Nuclear Cardiology
title: Myocardial perfusion scintigraphy in Europe 2007: a survey of the European Council of Nuclear Cardiology
venue: European Journal of Nuclear Medicine and Molecular Imaging
year: 2011

abstract: PurposeClinical applicability of the appropriate use criteria for SPECT myocardial perfusion imaging has not yet been evaluated in Italy. We investigated the applicability of the Appropriate Use Criteria (AUC) in Italy.MethodsThe indications for testing were prospectively recorded in three different nuclear cardiology laboratories: a general hospital, an academic hospital, and a tertiary centre. Indications were categorized as appropriate, uncertain or inappropriate according to the 2009 AUC; the specialty of the ordering physician was also noted. SPECT results were classified as: normal, probably normal, uncertain, probably abnormal, abnormal. The presence and severity of ischaemia were also noted.ResultsOver a 9 month period, 2,134 patients (age 67 10 years, 68 men) were evaluated (62 exercise stress test) On average, there were 700 (84 appropriate, 73 (7 inappropriate and 93 (9 uncertain tests. The rates for the appropriateness of indications were comparable in men and women (84 and 83 not significant) As expected, the rate of nonnormal studies was higher (58 for appropriate than for inappropriate (33 indications. Appropriateness was lower in the tertiary centre (74 and uncertain (16 and inappropriate (10 indications were more common; this was related to the higher rate of outpatients scheduled by nonhospital cardiologists (37 The most common indications associated with inappropriate testing were: chest pain, low likelihood of coronary artery disease, interpretable ECG and able to exercise (29 and asymptomatic <2 years after percutaneous coronary intervention (24 .ConclusionIn this preliminary evaluation of the AUC in Italy, the majority of studies were classified as appropriate, but a consistent proportion of scheduled SPECT studies, particularly by nonhospital cardiologists, were still categorized as uncertain or inappropriate. Educational approaches should be implemented to reduce the rate of less appropriate examinations. However, a substantial proportion (33 of inappropriate studies were classified as nonnormal, with 26 of these patients having ischaemia.
author_names: Giuseppe Medolago

C Claudio Marcassa

Ahmed Alkraisheh

Riccardo Campini

Adrian Ghilardi

Raffaele Giubbini

on behalf of the European Council of Nuclear Cardiology
title: Applicability of the appropriate use criteria for SPECT myocardial perfusion imaging in Italy: preliminary results
venue: European Journal of Nuclear Medicine and Molecular Imaging
year: 2014

abstract: The burden of cardiovascular diseases (CVDs) in the world is ever growing. They represent the first cause of death worldwide and in Latin America. Nuclear cardiology has a well established role in the management of patient with CVDs and is being increasingly integrated into the healthcare systems in the region. However, there remains variability as to the infrastructure available across the countries, in terms of existing technology, radiopharmaceuticals, and human resources. The approximate number of gamma (g) cameras in the region is 1348, with an average of 2.25 per million population; Argentina and Brazil having the largest number. Nearly 80% of the existing cameras are single photon emission tomography (SPECT) of which 8% are hybrid SPECT CT systems. Positron emission tomography technology is steadily increasing, and currently, there is an average of 0.25 scanners per million inhabitants, indicating that there is a potential to expand the capacities in order to cover the needs. Four countries have nuclear reactors for research purposes, which allow the production of technetium 99 m (Argentina, Chile, Mexico and Peru) while four (Argentina, Brazil, Cuba, and Mexico) assemble 99Mo 99mTc generators. As for the nuclear cardiology studies, about 80% of studies performed are gated SPECT myocardial perfusion imaging; less than 10% are multi gated acquisition (mainly for evaluation of cardiac toxicity in cancer patients) and the other 10% correspond to other types of studies, such as viability detection, and adrenergic innervation studies with 123I MIBG. Physical stress is preferred, when possible, based on the clinical condition of the patient. Regarding human resources, there is an average of 1.1 physicians and 1.3 technologists per g camera, with 0.1 medical physicists and 0.1 radiopharmacists per center in the region. The future of nuclear cardiology in Latin America and the Caribbean is encouraging, with great potential and possibilities for growth. National, regional, and international cooperation including support from scientific societies and organizations such as International Atomic Energy Agency, American Society of Nuclear Cardiology, and Latin American Association of Biology and Nuclear Medicine Societies, as well as governmental commitment are key factors for the development of the specialty. A multimodality approach in cardiac imaging will contribute to a better management of patients with CVDs.
author_names: Diana Paez

Amalia Peix

Pilar Orellana

Joao Vicente Vitola

Fernando Mut

C Gutierrez

Crosby Plaza

Tarik Becic

Maurizio Dondi

Enrique Estrada

on behalf of the pertussis Eqa participants
title: Current status of nuclear cardiology practice in Latin America and the Caribbean
venue: Journal of Nuclear Cardiology
year: 2016