-- DBMS: snowflake
create or replace TABLE MASKED_SOMATIC_MUTATION_HG38_GDC_R36 (
	"project_short_name" VARCHAR(16777216),
	"case_barcode" VARCHAR(16777216),
	"primary_site" VARCHAR(16777216),
	"Hugo_Symbol" VARCHAR(16777216),
	"Entrez_Gene_Id" NUMBER(38,0),
	"Center" VARCHAR(16777216),
	"NCBI_Build" VARCHAR(16777216),
	"Chromosome" VARCHAR(16777216),
	"Start_Position" NUMBER(38,0),
	"End_Position" NUMBER(38,0),
	"Strand" VARCHAR(16777216),
	"Variant_Classification" VARCHAR(16777216),
	"Variant_Type" VARCHAR(16777216),
	"Reference_Allele" VARCHAR(16777216),
	"Tumor_Seq_Allele1" VARCHAR(16777216),
	"Tumor_Seq_Allele2" VARCHAR(16777216),
	"dbSNP_RS" VARCHAR(16777216),
	"dbSNP_Val_Status" VARCHAR(16777216),
	"Tumor_Aliquot_Barcode" VARCHAR(16777216),
	"Matched_Norm_Aliquot_Barcode" VARCHAR(16777216),
	"Match_Norm_Seq_Allele1" VARCHAR(16777216),
	"Match_Norm_Seq_Allele2" VARCHAR(16777216),
	"Tumor_Validation_Allele1" VARCHAR(16777216),
	"Tumor_Validation_Allele2" VARCHAR(16777216),
	"Match_Norm_Validation_Allele1" VARCHAR(16777216),
	"Match_Norm_Validation_Allele2" VARCHAR(16777216),
	"Verification_Status" VARCHAR(16777216),
	"Validation_Status" VARCHAR(16777216),
	"Mutation_Status" VARCHAR(16777216),
	"Sequencing_Phase" VARCHAR(16777216),
	"Sequence_Source" VARCHAR(16777216),
	"Validation_Method" VARCHAR(16777216),
	"Score" VARCHAR(16777216),
	"BAM_File" VARCHAR(16777216),
	"Sequencer" VARCHAR(16777216),
	"Tumor_Aliquot_UUID" VARCHAR(16777216),
	"Matched_Norm_Aliquot_UUID" VARCHAR(16777216),
	"HGVSc" VARCHAR(16777216),
	"HGVSp" VARCHAR(16777216),
	"HGVSp_Short" VARCHAR(16777216),
	"Transcript_ID" VARCHAR(16777216),
	"Exon_Number" VARCHAR(16777216),
	"t_depth" NUMBER(38,0),
	"t_ref_count" NUMBER(38,0),
	"t_alt_count" NUMBER(38,0),
	"n_depth" NUMBER(38,0),
	"n_ref_count" VARCHAR(16777216),
	"n_alt_count" VARCHAR(16777216),
	"all_effects" VARCHAR(16777216),
	"Allele" VARCHAR(16777216),
	"Gene" VARCHAR(16777216),
	"Feature" VARCHAR(16777216),
	"Feature_type" VARCHAR(16777216),
	"One_Consequence" VARCHAR(16777216),
	"Consequence" VARCHAR(16777216),
	"cDNA_position" VARCHAR(16777216),
	"CDS_position" VARCHAR(16777216),
	"Protein_position" VARCHAR(16777216),
	"Amino_acids" VARCHAR(16777216),
	"Codons" VARCHAR(16777216),
	"Existing_variation" VARCHAR(16777216),
	DISTANCE VARCHAR(16777216),
	TRANSCRIPT_STRAND VARCHAR(16777216),
	SYMBOL VARCHAR(16777216),
	SYMBOL_SOURCE VARCHAR(16777216),
	HGNC_ID VARCHAR(16777216),
	BIOTYPE VARCHAR(16777216),
	CANONICAL VARCHAR(16777216),
	CCDS VARCHAR(16777216),
	ENSP VARCHAR(16777216),
	SWISSPROT VARCHAR(16777216),
	TREMBL VARCHAR(16777216),
	UNIPARC VARCHAR(16777216),
	UNIPROT_ISOFORM VARCHAR(16777216),
	"RefSeq" VARCHAR(16777216),
	MANE VARCHAR(16777216),
	APPRIS VARCHAR(16777216),
	FLAGS VARCHAR(16777216),
	SIFT VARCHAR(16777216),
	"PolyPhen" VARCHAR(16777216),
	EXON VARCHAR(16777216),
	INTRON VARCHAR(16777216),
	DOMAINS VARCHAR(16777216),
	"ThousG_AF" FLOAT,
	"ThousG_AFR_AF" FLOAT,
	"ThousG_AMR_AF" FLOAT,
	"ThousG_EAS_AF" FLOAT,
	"ThousG_EUR_AF" FLOAT,
	"ThousG_SAS_AF" FLOAT,
	ESP_AA_AF FLOAT,
	ESP_EA_AF FLOAT,
	"gnomAD_AF" FLOAT,
	"gnomAD_AFR_AF" FLOAT,
	"gnomAD_AMR_AF" FLOAT,
	"gnomAD_ASJ_AF" FLOAT,
	"gnomAD_EAS_AF" FLOAT,
	"gnomAD_FIN_AF" FLOAT,
	"gnomAD_NFE_AF" FLOAT,
	"gnomAD_OTH_AF" FLOAT,
	"gnomAD_SAS_AF" FLOAT,
	MAX_AF FLOAT,
	MAX_AF_POPS VARCHAR(16777216),
	"gnomAD_non_cancer_AF" FLOAT,
	"gnomAD_non_cancer_AFR_AF" FLOAT,
	"gnomAD_non_cancer_AMI_AF" FLOAT,
	"gnomAD_non_cancer_AMR_AF" FLOAT,
	"gnomAD_non_cancer_ASJ_AF" FLOAT,
	"gnomAD_non_cancer_EAS_AF" FLOAT,
	"gnomAD_non_cancer_FIN_AF" FLOAT,
	"gnomAD_non_cancer_MID_AF" FLOAT,
	"gnomAD_non_cancer_NFE_AF" FLOAT,
	"gnomAD_non_cancer_OTH_AF" FLOAT,
	"gnomAD_non_cancer_SAS_AF" FLOAT,
	"gnomAD_non_cancer_MAX_AF_adj" FLOAT,
	"gnomAD_non_cancer_MAX_AF_POPS_adj" VARCHAR(16777216),
	CLIN_SIG VARCHAR(16777216),
	SOMATIC VARCHAR(16777216),
	PUBMED VARCHAR(16777216),
	TRANSCRIPTION_FACTORS VARCHAR(16777216),
	MOTIF_NAME VARCHAR(16777216),
	MOTIF_POS VARCHAR(16777216),
	HIGH_INF_POS VARCHAR(16777216),
	MOTIF_SCORE_CHANGE VARCHAR(16777216),
	"miRNA" VARCHAR(16777216),
	IMPACT VARCHAR(16777216),
	PICK VARCHAR(16777216),
	VARIANT_CLASS VARCHAR(16777216),
	TSL VARCHAR(16777216),
	HGVS_OFFSET VARCHAR(16777216),
	PHENO VARCHAR(16777216),
	GENE_PHENO VARCHAR(16777216),
	CONTEXT VARCHAR(16777216),
	"tumor_submitter_uuid" VARCHAR(16777216),
	"normal_submitter_uuid" VARCHAR(16777216),
	"case_id" VARCHAR(16777216),
	GDC_FILTER VARCHAR(16777216),
	COSMIC VARCHAR(16777216),
	"hotspot" BOOLEAN,
	"RNA_Support" VARCHAR(16777216),
	"RNA_depth" VARCHAR(16777216),
	"RNA_ref_count" VARCHAR(16777216),
	"RNA_alt_count" VARCHAR(16777216),
	"callers" VARCHAR(16777216),
	"file_gdc_id" VARCHAR(16777216),
	"muse" VARCHAR(16777216),
	"mutect2" VARCHAR(16777216),
	"pindel" VARCHAR(16777216),
	"varscan2" VARCHAR(16777216),
	"sample_barcode_tumor" VARCHAR(16777216),
	"sample_barcode_normal" VARCHAR(16777216),
	"aliquot_barcode_tumor" VARCHAR(16777216),
	"aliquot_barcode_normal" VARCHAR(16777216)
);

INSERT INTO "TCGA_MITELMAN"."TCGA_VERSIONED"."MASKED_SOMATIC_MUTATION_HG38_GDC_R36" (SWISSPROT, CLIN_SIG, n_alt_count, RNA_ref_count, gnomAD_non_cancer_SAS_AF, Tumor_Aliquot_UUID, ThousG_SAS_AF, Feature, RNA_alt_count, sample_barcode_tumor, Reference_Allele, MANE, PUBMED, gnomAD_AMR_AF, MOTIF_SCORE_CHANGE, CDS_position, gnomAD_NFE_AF, SOMATIC, TREMBL, Match_Norm_Validation_Allele2, case_barcode, CCDS, Variant_Classification, CONTEXT, gnomAD_non_cancer_AMI_AF, gnomAD_EAS_AF, hotspot, gnomAD_OTH_AF, BIOTYPE, Matched_Norm_Aliquot_UUID, varscan2, t_depth, GDC_FILTER, Tumor_Validation_Allele2, pindel, tumor_submitter_uuid, Consequence, Codons, gnomAD_non_cancer_MID_AF, Sequence_Source, gnomAD_FIN_AF, primary_site, Center, ThousG_AF, t_alt_count, gnomAD_SAS_AF, gnomAD_non_cancer_AFR_AF, gnomAD_non_cancer_MAX_AF_POPS_adj, UNIPARC, gnomAD_ASJ_AF, ESP_AA_AF, TRANSCRIPT_STRAND, DOMAINS, HGVSc, MOTIF_POS, miRNA, all_effects, COSMIC, Tumor_Seq_Allele2, Strand, Validation_Status, CANONICAL, EXON, Matched_Norm_Aliquot_Barcode, Existing_variation, HGNC_ID, Start_Position, SYMBOL, cDNA_position, ThousG_EUR_AF, Validation_Method, INTRON, t_ref_count, Variant_Type, Match_Norm_Seq_Allele1, Tumor_Seq_Allele1, PHENO, VARIANT_CLASS, Verification_Status, HGVS_OFFSET, Entrez_Gene_Id, TRANSCRIPTION_FACTORS, gnomAD_AF, gnomAD_non_cancer_FIN_AF, Match_Norm_Validation_Allele1, One_Consequence, APPRIS, aliquot_barcode_normal, Sequencing_Phase, Feature_type, Mutation_Status, Score, ThousG_AMR_AF, Allele, gnomAD_non_cancer_OTH_AF, HGVSp_Short, DISTANCE, n_depth, sample_barcode_normal, callers, gnomAD_non_cancer_EAS_AF, Tumor_Validation_Allele1, case_id, Sequencer, dbSNP_Val_Status, ThousG_AFR_AF, project_short_name, ThousG_EAS_AF, MOTIF_NAME, MAX_AF_POPS, gnomAD_non_cancer_ASJ_AF, RNA_depth, Protein_position, SYMBOL_SOURCE, file_gdc_id, Chromosome, gnomAD_non_cancer_AF, aliquot_barcode_tumor, HIGH_INF_POS, gnomAD_AFR_AF, Transcript_ID, RNA_Support, RefSeq, mutect2, muse, Amino_acids, PolyPhen, Hugo_Symbol, IMPACT, gnomAD_non_cancer_NFE_AF, gnomAD_non_cancer_AMR_AF, Match_Norm_Seq_Allele2, BAM_File, MAX_AF, PICK, ENSP, gnomAD_non_cancer_MAX_AF_adj, Gene, NCBI_Build, UNIPROT_ISOFORM, ESP_EA_AF, SIFT, dbSNP_RS, End_Position, normal_submitter_uuid, Tumor_Aliquot_Barcode, TSL, HGVSp, FLAGS, GENE_PHENO, n_ref_count, Exon_Number) VALUES ('Q8NHM5.173', NULL, NULL, NULL, nan, '3331813c-f538-4833-b5eb-a214b7d52334', NULL, 'ENST00000377071', NULL, 'TCGA-02-2486-01A', 'C', 'NM_032590.5', NULL, 0.0, NULL, '2944/4011', 9.371e-06, '0;1', NULL, NULL, 'TCGA-02-2486', 'CCDS41850.1', 'Missense_Mutation', 'CTCCTCGCCCT', nan, 0.0, False, 0.0, 'protein_coding', '334697ef-d664-4d24-9ddb-c4d7448fd00d', 'Yes', 77, NULL, NULL, 'No', 'd5b9408d-e95e-41d5-b1de-8dd6e50b572b', 'missense_variant', 'Gag/Aag', nan, NULL, 0.0, 'Brain', 'BI', NULL, 20, 0.0, nan, NULL, 'UPI000006F36E', 0.0, NULL, '-1', 'Low_complexity_(Seg):seg;MobiDB_lite:mobidb-lite;MobiDB_lite:mobidb-lite;PANTHER:PTHR23123;PANTHER:PTHR23123:SF10', 'c.2944G>A', NULL, NULL, 'KDM2B,missense_variant,p.E982K,ENST00000377071,NM_032590.5,c.2944G>A,MODERATE,YES,deleterious_low_confidence(0.02),benign(0.023),-1;KDM2B,missense_variant,p.E913K,ENST00000377069,NM_001005366.2,c.2737G>A,MODERATE,,deleterious(0.01),benign(0.191),-1;KDM2B,missense_variant,p.E350K,ENST00000542973,,c.1048G>A,MODERATE,,deleterious(0.05),benign(0.023),-1;KDM2B,intron_variant,,ENST00000536437,,c.2104-2624G>A,MODIFIER,,,,-1;KDM2B,intron_variant,,ENST00000611216,,c.1608+10623G>A,MODIFIER,,,,-1;MIR7107,downstream_gene_variant,,ENST00000611489,,,MODIFIER,YES,,,-1;KDM2B,non_coding_transcript_exon_variant,,ENST00000538503,,n.4090G>A,MODIFIER,,,,-1;KDM2B,intron_variant,,ENST00000543025,,c.*1565+10623G>A,MODIFIER,,,,-1;KDM2B,upstream_gene_variant,,ENST00000536036,,,MODIFIER,,,,-1;KDM2B,downstream_gene_variant,,ENST00000538243,,,MODIFIER,,,,-1', 'COSM3398446;COSM3398447;COSM3398448', 'T', '+', NULL, 'YES', '19/23', 'TCGA-02-2486-10A-01D-1494-08', 'rs782132082;COSV65640263', 'HGNC:13610', 121442497, 'KDM2B', '3056/5315', NULL, NULL, NULL, 56, 'SNP', NULL, 'C', '0;1', 'SNV', NULL, NULL, 84678, NULL, 4.328e-06, nan, NULL, 'missense_variant', 'P4', 'TCGA-02-2486-10A-01D-1494-08', NULL, 'Transcript', 'Somatic', NULL, NULL, 'T', nan, 'p.E982K', NULL, 55, 'TCGA-02-2486-10A', 'muse;mutect2;varscan2', nan, NULL, '79a68b32-29a3-47bf-9b2b-643ec7323d73', NULL, NULL, NULL, 'TCGA-GBM', NULL, NULL, 'gnomAD_NFE', nan, NULL, '982/1336', 'HGNC', '523e6728-6954-4f10-9ca3-2beb93a00eaa', 'chr12', nan, 'TCGA-02-2486-01A-01D-1494-08', NULL, 0.0, 'ENST00000377071', 'Unknown', 'NM_032590.5', 'Yes', 'Yes', 'E/K', 'benign(0.023)', 'KDM2B', 'MODERATE', nan, nan, NULL, NULL, 9.371e-06, '1', 'ENSP00000366271', nan, 'ENSG00000089094', 'GRCh38', 'Q8NHM5-1', NULL, 'deleterious_low_confidence(0.02)', 'rs782132082', 121442497, '33685a0d-5a70-414c-969e-dfedfeb714a8', 'TCGA-02-2486-01A-01D-1494-08', '1', 'p.Glu982Lys', NULL, NULL, NULL, '19/23'), ('Q9NX61.128', NULL, NULL, NULL, nan, '3331813c-f538-4833-b5eb-a214b7d52334', NULL, 'ENST00000162044', NULL, 'TCGA-02-2486-01A', 'T', 'NM_017814.3', NULL, 0.0, NULL, '679/1440', 0.0, '0;1', NULL, NULL, 'TCGA-02-2486', 'CCDS12393.1', 'Missense_Mutation', 'GCGGATAGCCA', nan, 0.0, False, 0.0, 'protein_coding', '334697ef-d664-4d24-9ddb-c4d7448fd00d', 'Yes', 65, NULL, NULL, 'No', 'd5b9408d-e95e-41d5-b1de-8dd6e50b572b', 'missense_variant', 'Atc/Gtc', nan, NULL, 0.0, 'Brain', 'BI', NULL, 26, 3.267e-05, nan, NULL, 'UPI00000373EF', 0.0, NULL, '-1', 'Pfam:PF10268;PANTHER:PTHR13624;PANTHER:PTHR13624:SF4;Transmembrane_helices:TMhelix', 'c.679A>G', NULL, NULL, 'TMEM161A,missense_variant,p.I227V,ENST00000162044,NM_017814.3,c.679A>G,MODERATE,YES,tolerated(0.38),benign(0.001),-1;TMEM161A,missense_variant,p.I124V,ENST00000450333,NM_001256766.2,c.370A>G,MODERATE,,tolerated(0.49),benign(0),-1;TMEM161A,missense_variant,p.I202V,ENST00000587583,,c.604A>G,MODERATE,,tolerated(0.39),benign(0.007),-1;TMEM161A,missense_variant,p.I210V,ENST00000587096,,c.628A>G,MODERATE,,tolerated(0.34),benign(0.001),-1;TMEM161A,missense_variant,p.I96V,ENST00000587925,,c.286A>G,MODERATE,,tolerated(0.52),benign(0.007),-1;TMEM161A,missense_variant,p.I227V,ENST00000587985,,c.679A>G,MODERATE,,tolerated(0.52),benign(0.007),-1;TMEM161A,non_coding_transcript_exon_variant,,ENST00000587406,,n.744A>G,MODIFIER,,,,-1;TMEM161A,non_coding_transcript_exon_variant,,ENST00000589448,,n.757A>G,MODIFIER,,,,-1;TMEM161A,non_coding_transcript_exon_variant,,ENST00000591031,,n.440A>G,MODIFIER,,,,-1;TMEM161A,downstream_gene_variant,,ENST00000590216,,,MODIFIER,,,,-1;TMEM161A,upstream_gene_variant,,ENST00000591443,,,MODIFIER,,,,-1', 'COSM3403980', 'C', '+', NULL, 'YES', '8/12', 'TCGA-02-2486-10A-01D-1494-08', 'rs761544241;COSV50776566', 'HGNC:26020', 19121646, 'TMEM161A', '729/2251', NULL, NULL, NULL, 38, 'SNP', NULL, 'T', '0;1', 'SNV', NULL, NULL, 54929, NULL, 3.996e-06, nan, NULL, 'missense_variant', 'P1', 'TCGA-02-2486-10A-01D-1494-08', NULL, 'Transcript', 'Somatic', NULL, NULL, 'C', nan, 'p.I227V', NULL, 63, 'TCGA-02-2486-10A', 'muse;mutect2;varscan2', nan, NULL, '79a68b32-29a3-47bf-9b2b-643ec7323d73', NULL, NULL, NULL, 'TCGA-GBM', NULL, NULL, 'gnomAD_SAS', nan, NULL, '227/479', 'HGNC', '523e6728-6954-4f10-9ca3-2beb93a00eaa', 'chr19', nan, 'TCGA-02-2486-01A-01D-1494-08', NULL, 0.0, 'ENST00000162044', 'Unknown', 'NM_017814.3', 'Yes', 'Yes', 'I/V', 'benign(0.001)', 'TMEM161A', 'MODERATE', nan, nan, NULL, NULL, 3.267e-05, '1', 'ENSP00000162044', nan, 'ENSG00000064545', 'GRCh38', 'Q9NX61-1', NULL, 'tolerated(0.38)', 'rs761544241', 19121646, '33685a0d-5a70-414c-969e-dfedfeb714a8', 'TCGA-02-2486-01A-01D-1494-08', '1', 'p.Ile227Val', NULL, NULL, NULL, '8/12'), ('O43298.178', NULL, NULL, NULL, 0.0, '21b50b8c-781a-4e15-a4ad-715f416f0fa2', NULL, 'ENST00000373457', NULL, 'TCGA-04-1347-01A', 'C', NULL, NULL, 5.794e-05, NULL, '1362/1404', 2.687e-05, '0;1', NULL, NULL, 'TCGA-04-1347', 'CCDS6867.1', 'Silent', 'TCCTACGAAGC', 0.0, 0.0, False, 0.0, 'protein_coding', '36e22642-4216-43dd-a3fc-52310081f5e0', 'Yes', 164, NULL, NULL, 'No', '07b787e5-0af6-4b06-adf7-a5c486400107', 'synonymous_variant', 'taC/taT', 0.0, NULL, 0.0, 'Ovary', 'BI;WUGSC', NULL, 39, 0.0, 4.870209886576049e-05, 'oth', 'UPI000013C34F', 0.0, NULL, '1', 'PDB-ENSP_mappings:2csh.A;PROSITE_profiles:PS50157;PANTHER:PTHR24414:SF43;PANTHER:PTHR24414;Gene3D:3.30.160.60', 'c.1362C>T', NULL, NULL, 'ZBTB43,synonymous_variant,p.Y454=,ENST00000373464,NM_014007.4,c.1362C>T,LOW,YES,,,1;ZBTB43,synonymous_variant,p.Y454=,ENST00000449886,NM_001135776.1,c.1362C>T,LOW,,,,1;ZBTB43,synonymous_variant,p.Y454=,ENST00000373457,,c.1362C>T,LOW,,,,1;ZBTB43,downstream_gene_variant,,ENST00000450858,,,MODIFIER,,,,1;ZBTB43,upstream_gene_variant,,ENST00000497064,,,MODIFIER,,,,1', 'COSM81930', 'T', '+', NULL, NULL, '1/1', 'TCGA-04-1347-11A-01W-0487-08', 'rs776691831;COSV65094390', 'HGNC:17908', 126833871, 'ZBTB43', '2463/5695', NULL, NULL, NULL, 125, 'SNP', NULL, 'C', '0;1', 'SNV', NULL, NULL, 23099, NULL, 2.015e-05, 0.0, NULL, 'synonymous_variant', 'P1', 'TCGA-04-1347-11A-01W-0487-08', NULL, 'Transcript', 'Somatic', NULL, NULL, 'T', 0.000991079956293106, 'p.Y454=', NULL, 331, 'TCGA-04-1347-11A', 'muse;mutect2;varscan2', 0.0, NULL, 'f0c353fd-947c-41e2-b643-3ecc0d69796c', NULL, NULL, NULL, 'TCGA-OV', NULL, NULL, 'gnomAD_AMR', 0.0, NULL, '454/467', 'HGNC', '818dbf34-acb1-4f65-bb95-bd00971f9179', 'chr9', 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