-- DBMS: snowflake
create or replace TABLE MASKED_SOMATIC_MUTATION_HG38_GDC_R39 (
	"project_short_name" VARCHAR(16777216),
	"case_barcode" VARCHAR(16777216),
	"primary_site" VARCHAR(16777216),
	"Hugo_Symbol" VARCHAR(16777216),
	"Entrez_Gene_Id" NUMBER(38,0),
	"Center" VARCHAR(16777216),
	"NCBI_Build" VARCHAR(16777216),
	"Chromosome" VARCHAR(16777216),
	"Start_Position" NUMBER(38,0),
	"End_Position" NUMBER(38,0),
	"Strand" VARCHAR(16777216),
	"Variant_Classification" VARCHAR(16777216),
	"Variant_Type" VARCHAR(16777216),
	"Reference_Allele" VARCHAR(16777216),
	"Tumor_Seq_Allele1" VARCHAR(16777216),
	"Tumor_Seq_Allele2" VARCHAR(16777216),
	"dbSNP_RS" VARCHAR(16777216),
	"dbSNP_Val_Status" VARCHAR(16777216),
	"Tumor_Aliquot_Barcode" VARCHAR(16777216),
	"Matched_Norm_Aliquot_Barcode" VARCHAR(16777216),
	"Match_Norm_Seq_Allele1" VARCHAR(16777216),
	"Match_Norm_Seq_Allele2" VARCHAR(16777216),
	"Tumor_Validation_Allele1" VARCHAR(16777216),
	"Tumor_Validation_Allele2" VARCHAR(16777216),
	"Match_Norm_Validation_Allele1" VARCHAR(16777216),
	"Match_Norm_Validation_Allele2" VARCHAR(16777216),
	"Verification_Status" VARCHAR(16777216),
	"Validation_Status" VARCHAR(16777216),
	"Mutation_Status" VARCHAR(16777216),
	"Sequencing_Phase" VARCHAR(16777216),
	"Sequence_Source" VARCHAR(16777216),
	"Validation_Method" VARCHAR(16777216),
	"Score" VARCHAR(16777216),
	"BAM_File" VARCHAR(16777216),
	"Sequencer" VARCHAR(16777216),
	"Tumor_Aliquot_UUID" VARCHAR(16777216),
	"Matched_Norm_Aliquot_UUID" VARCHAR(16777216),
	"HGVSc" VARCHAR(16777216),
	"HGVSp" VARCHAR(16777216),
	"HGVSp_Short" VARCHAR(16777216),
	"Transcript_ID" VARCHAR(16777216),
	"Exon_Number" VARCHAR(16777216),
	"t_depth" NUMBER(38,0),
	"t_ref_count" NUMBER(38,0),
	"t_alt_count" NUMBER(38,0),
	"n_depth" NUMBER(38,0),
	"n_ref_count" VARCHAR(16777216),
	"n_alt_count" VARCHAR(16777216),
	"all_effects" VARCHAR(16777216),
	"Allele" VARCHAR(16777216),
	"Gene" VARCHAR(16777216),
	"Feature" VARCHAR(16777216),
	"Feature_type" VARCHAR(16777216),
	"One_Consequence" VARCHAR(16777216),
	"Consequence" VARCHAR(16777216),
	"cDNA_position" VARCHAR(16777216),
	"CDS_position" VARCHAR(16777216),
	"Protein_position" VARCHAR(16777216),
	"Amino_acids" VARCHAR(16777216),
	"Codons" VARCHAR(16777216),
	"Existing_variation" VARCHAR(16777216),
	DISTANCE VARCHAR(16777216),
	TRANSCRIPT_STRAND VARCHAR(16777216),
	SYMBOL VARCHAR(16777216),
	SYMBOL_SOURCE VARCHAR(16777216),
	HGNC_ID VARCHAR(16777216),
	BIOTYPE VARCHAR(16777216),
	CANONICAL VARCHAR(16777216),
	CCDS VARCHAR(16777216),
	ENSP VARCHAR(16777216),
	SWISSPROT VARCHAR(16777216),
	TREMBL VARCHAR(16777216),
	UNIPARC VARCHAR(16777216),
	UNIPROT_ISOFORM VARCHAR(16777216),
	"RefSeq" VARCHAR(16777216),
	MANE VARCHAR(16777216),
	APPRIS VARCHAR(16777216),
	FLAGS VARCHAR(16777216),
	SIFT VARCHAR(16777216),
	"PolyPhen" VARCHAR(16777216),
	EXON VARCHAR(16777216),
	INTRON VARCHAR(16777216),
	DOMAINS VARCHAR(16777216),
	"ThousG_AF" FLOAT,
	"ThousG_AFR_AF" FLOAT,
	"ThousG_AMR_AF" FLOAT,
	"ThousG_EAS_AF" FLOAT,
	"ThousG_EUR_AF" FLOAT,
	"ThousG_SAS_AF" FLOAT,
	ESP_AA_AF FLOAT,
	ESP_EA_AF FLOAT,
	"gnomAD_AF" FLOAT,
	"gnomAD_AFR_AF" FLOAT,
	"gnomAD_AMR_AF" FLOAT,
	"gnomAD_ASJ_AF" FLOAT,
	"gnomAD_EAS_AF" FLOAT,
	"gnomAD_FIN_AF" FLOAT,
	"gnomAD_NFE_AF" FLOAT,
	"gnomAD_OTH_AF" FLOAT,
	"gnomAD_SAS_AF" FLOAT,
	MAX_AF FLOAT,
	MAX_AF_POPS VARCHAR(16777216),
	"gnomAD_non_cancer_AF" FLOAT,
	"gnomAD_non_cancer_AFR_AF" FLOAT,
	"gnomAD_non_cancer_AMI_AF" FLOAT,
	"gnomAD_non_cancer_AMR_AF" FLOAT,
	"gnomAD_non_cancer_ASJ_AF" FLOAT,
	"gnomAD_non_cancer_EAS_AF" FLOAT,
	"gnomAD_non_cancer_FIN_AF" FLOAT,
	"gnomAD_non_cancer_MID_AF" FLOAT,
	"gnomAD_non_cancer_NFE_AF" FLOAT,
	"gnomAD_non_cancer_OTH_AF" FLOAT,
	"gnomAD_non_cancer_SAS_AF" FLOAT,
	"gnomAD_non_cancer_MAX_AF_adj" FLOAT,
	"gnomAD_non_cancer_MAX_AF_POPS_adj" VARCHAR(16777216),
	CLIN_SIG VARCHAR(16777216),
	SOMATIC VARCHAR(16777216),
	PUBMED VARCHAR(16777216),
	TRANSCRIPTION_FACTORS VARCHAR(16777216),
	MOTIF_NAME VARCHAR(16777216),
	MOTIF_POS VARCHAR(16777216),
	HIGH_INF_POS VARCHAR(16777216),
	MOTIF_SCORE_CHANGE VARCHAR(16777216),
	"miRNA" VARCHAR(16777216),
	IMPACT VARCHAR(16777216),
	PICK VARCHAR(16777216),
	VARIANT_CLASS VARCHAR(16777216),
	TSL VARCHAR(16777216),
	HGVS_OFFSET VARCHAR(16777216),
	PHENO VARCHAR(16777216),
	GENE_PHENO VARCHAR(16777216),
	CONTEXT VARCHAR(16777216),
	"tumor_submitter_uuid" VARCHAR(16777216),
	"normal_submitter_uuid" VARCHAR(16777216),
	"case_id" VARCHAR(16777216),
	GDC_FILTER VARCHAR(16777216),
	COSMIC VARCHAR(16777216),
	"hotspot" BOOLEAN,
	"RNA_Support" VARCHAR(16777216),
	"RNA_depth" VARCHAR(16777216),
	"RNA_ref_count" VARCHAR(16777216),
	"RNA_alt_count" VARCHAR(16777216),
	"callers" VARCHAR(16777216),
	"file_gdc_id" VARCHAR(16777216),
	"muse" VARCHAR(16777216),
	"mutect2" VARCHAR(16777216),
	"pindel" VARCHAR(16777216),
	"varscan2" VARCHAR(16777216),
	"sample_barcode_tumor" VARCHAR(16777216),
	"sample_barcode_normal" VARCHAR(16777216),
	"aliquot_barcode_tumor" VARCHAR(16777216),
	"aliquot_barcode_normal" VARCHAR(16777216)
);

INSERT INTO "TCGA"."TCGA_VERSIONED"."MASKED_SOMATIC_MUTATION_HG38_GDC_R39" (tumor_submitter_uuid, CCDS, dbSNP_RS, GDC_FILTER, n_alt_count, hotspot, COSMIC, Score, UNIPARC, Allele, Matched_Norm_Aliquot_Barcode, t_alt_count, aliquot_barcode_normal, gnomAD_non_cancer_FIN_AF, One_Consequence, muse, ESP_AA_AF, n_depth, RNA_Support, gnomAD_non_cancer_SAS_AF, SOMATIC, Validation_Method, gnomAD_NFE_AF, PICK, MAX_AF_POPS, t_depth, miRNA, ThousG_EAS_AF, HGVS_OFFSET, HGNC_ID, Matched_Norm_Aliquot_UUID, Tumor_Seq_Allele2, dbSNP_Val_Status, t_ref_count, case_barcode, RNA_depth, BIOTYPE, Gene, gnomAD_AF, Variant_Type, GENE_PHENO, End_Position, gnomAD_AMR_AF, gnomAD_non_cancer_ASJ_AF, Tumor_Validation_Allele2, RNA_ref_count, CDS_position, MOTIF_SCORE_CHANGE, Start_Position, gnomAD_non_cancer_MAX_AF_POPS_adj, EXON, PolyPhen, HGVSp_Short, gnomAD_EAS_AF, Tumor_Aliquot_UUID, Verification_Status, primary_site, Exon_Number, Codons, Validation_Status, all_effects, RefSeq, Sequence_Source, gnomAD_non_cancer_AMR_AF, pindel, sample_barcode_normal, CLIN_SIG, HIGH_INF_POS, file_gdc_id, Tumor_Validation_Allele1, FLAGS, ESP_EA_AF, BAM_File, project_short_name, ThousG_SAS_AF, Consequence, mutect2, NCBI_Build, Variant_Classification, Protein_position, ENSP, ThousG_AMR_AF, TREMBL, Match_Norm_Seq_Allele2, HGVSc, Amino_acids, Entrez_Gene_Id, cDNA_position, TRANSCRIPTION_FACTORS, normal_submitter_uuid, ThousG_AFR_AF, case_id, Existing_variation, aliquot_barcode_tumor, Match_Norm_Validation_Allele2, APPRIS, MOTIF_POS, TSL, Tumor_Seq_Allele1, INTRON, gnomAD_non_cancer_EAS_AF, gnomAD_non_cancer_AF, Match_Norm_Seq_Allele1, gnomAD_non_cancer_MAX_AF_adj, n_ref_count, RNA_alt_count, Feature, Center, DISTANCE, gnomAD_FIN_AF, CANONICAL, Hugo_Symbol, varscan2, PHENO, MANE, TRANSCRIPT_STRAND, Reference_Allele, HGVSp, SYMBOL, gnomAD_SAS_AF, Sequencing_Phase, UNIPROT_ISOFORM, SYMBOL_SOURCE, SIFT, VARIANT_CLASS, MOTIF_NAME, Feature_type, gnomAD_non_cancer_NFE_AF, gnomAD_ASJ_AF, Mutation_Status, gnomAD_non_cancer_OTH_AF, IMPACT, CONTEXT, MAX_AF, gnomAD_AFR_AF, Strand, sample_barcode_tumor, gnomAD_OTH_AF, Tumor_Aliquot_Barcode, gnomAD_non_cancer_AFR_AF, ThousG_EUR_AF, Match_Norm_Validation_Allele1, Sequencer, Transcript_ID, SWISSPROT, ThousG_AF, DOMAINS, callers, PUBMED, gnomAD_non_cancer_AMI_AF, Chromosome, gnomAD_non_cancer_MID_AF) VALUES ('5aa2d6c0-4a4a-42b7-a663-591c0716b0f2', 'CCDS32155.1', 'rs764781997', NULL, NULL, False, 'COSM2148885', NULL, 'UPI000013D278', 'A', 'TCGA-02-0003-10A-01D-1490-08', 52, 'TCGA-02-0003-10A-01D-1490-08', nan, 'missense_variant', 'Yes', NULL, 90, 'Unknown', nan, '0;1', NULL, 2.664e-05, NULL, 'gnomAD_SAS', 100, NULL, NULL, NULL, 'HGNC:3330', '0b63ce82-23d2-48d4-be99-3959917d94ea', 'A', NULL, 46, 'TCGA-02-0003', NULL, 'protein_coding', 'ENSG00000066629', 2.418e-05, 'SNP', '1', 99897269, 0.0, nan, NULL, NULL, '802/2448', NULL, 99897269, NULL, '7/22', 'benign(0)', 'p.A268T', 0.0, '458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23', NULL, 'Brain', '7/22', 'Gct/Act', NULL, 'EML1,missense_variant,p.A293T,ENST00000649352,,c.877G>A,MODERATE,YES,tolerated(0.24),benign(0.003),1;EML1,missense_variant,p.A268T,ENST00000262233,NM_001375411.1&NM_004434.3&NM_001375412.1,c.802G>A,MODERATE,,tolerated(0.25),benign(0),1;EML1,missense_variant,p.A287T,ENST00000334192,NM_001008707.2,c.859G>A,MODERATE,,tolerated(0.27),benign(0.001),1;EML1,missense_variant,p.A256T,ENST00000327921,,c.766G>A,MODERATE,,tolerated(0.24),benign(0),1;EML1,missense_variant,p.A255T,ENST00000554479,,c.763G>A,MODERATE,,tolerated(0.19),benign(0),1;EML1,missense_variant,p.A237T,ENST00000556714,,c.709G>A,MODERATE,,tolerated(0.15),benign(0),1;EML1,upstream_gene_variant,,ENST00000554386,,,MODIFIER,,,,1;EML1,upstream_gene_variant,,ENST00000555812,,,MODIFIER,,,,1;EML1,missense_variant,p.A10T,ENST00000554553,,c.28G>A,MODERATE,,tolerated(0.34),benign(0.001),1;EML1,non_coding_transcript_exon_variant,,ENST00000555277,,n.431G>A,MODIFIER,,,,1', 'NM_001375411.1;NM_004434.3;NM_001375412.1', NULL, nan, 'No', 'TCGA-02-0003-10A', NULL, NULL, '6fd169e5-a79b-405f-8c4e-b20a03d8a4a9', NULL, NULL, NULL, NULL, 'TCGA-GBM', NULL, 'missense_variant', 'Yes', 'GRCh38', 'Missense_Mutation', '268/815', 'ENSP00000262233', NULL, NULL, NULL, 'c.802G>A', 'A/T', 2009, '866/4460', NULL, '8bdcb466-e141-45b4-8d5a-975bd3dd0cde', NULL, 'df3c1d61-79c1-43e9-971a-8029497ffeab', 'rs764781997;COSV51746801', 'TCGA-02-0003-01A-01D-1490-08', NULL, 'P4', NULL, '1', 'G', NULL, nan, nan, NULL, nan, NULL, NULL, 'ENST00000262233', 'BI', NULL, 0.0, NULL, 'EML1', 'Yes', '0;1', 'NM_004434.3', '1', 'G', 'p.Ala268Thr', 'EML1', 9.958e-05, NULL, 'O00423-1', 'HGNC', 'tolerated(0.25)', 'SNV', NULL, 'Transcript', nan, 0.0, 'Somatic', nan, 'MODERATE', 'ATTACGCTGGC', 9.958e-05, 0.0, '+', 'TCGA-02-0003-01A', 0.0, 'TCGA-02-0003-01A-01D-1490-08', nan, NULL, NULL, NULL, 'ENST00000262233', 'O00423.177', NULL, 'PDB-ENSP_mappings:4ci8.A;PDB-ENSP_mappings:4ci8.B;Superfamily:SSF50998;SMART:SM00320;Pfam:PF00400;Gene3D:2.130.10.10;Gene3D:2.130.10.10;PANTHER:PTHR13720:SF22;PANTHER:PTHR13720', 'muse;mutect2;varscan2', NULL, nan, 'chr14', nan), ('634033ea-10ce-47d0-8298-63a7c3e3e89b', 'CCDS5254.1', 'rs772199451', NULL, NULL, False, 'COSM2149100;COSM2149101', NULL, 'UPI000006E2F8', 'A', 'TCGA-02-2470-10A-01D-1494-08', 40, 'TCGA-02-2470-10A-01D-1494-08', nan, 'missense_variant', 'Yes', NULL, 226, 'Unknown', nan, '0;1', NULL, 8.84e-06, '1', 'gnomAD_ASJ', 194, NULL, NULL, NULL, 'HGNC:11504', '1ab37cba-6ad6-4825-98bb-b8e102f64ed2', 'A', NULL, 154, 'TCGA-02-2470', NULL, 'protein_coding', 'ENSG00000078269', 7.979e-06, 'SNP', NULL, 158062164, 0.0, nan, NULL, NULL, '1127/4491', NULL, 158062164, NULL, '8/27', 'probably_damaging(0.964)', 'p.R376H', 0.0, '0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224', NULL, 'Brain', '8/27', 'cGt/cAt', NULL, 'SYNJ2,missense_variant,p.R376H,ENST00000355585,NM_003898.4,c.1127G>A,MODERATE,YES,deleterious(0.01),probably_damaging(0.964),1;SYNJ2,missense_variant,p.R139H,ENST00000638626,NM_001178088.2,c.416G>A,MODERATE,,deleterious(0.01),probably_damaging(0.964),1;SYNJ2,missense_variant,p.R376H,ENST00000640338,,c.1127G>A,MODERATE,,deleterious(0),probably_damaging(0.909),1;SYNJ2,splice_region_variant,,ENST00000485863,,c.*231G>A,LOW,,,,1', 'NM_003898.4', NULL, nan, 'No', 'TCGA-02-2470-10A', NULL, NULL, '39bc8e0a-7e9d-4d5e-b0cc-3c3a5d3cba6d', NULL, NULL, NULL, NULL, 'TCGA-GBM', NULL, 'missense_variant;splice_region_variant', 'Yes', 'GRCh38', 'Missense_Mutation', '376/1496', 'ENSP00000347792', NULL, NULL, NULL, 'c.1127G>A', 'R/H', 8871, '1226/7402', NULL, 'a67953ea-2409-4a42-9056-a90e97549cb0', NULL, 'e948d951-9299-4dec-9772-60b4ac3569cb', 'rs772199451;COSV62895768', 'TCGA-02-2470-01A-01D-1494-08', NULL, 'P3', NULL, '1', 'G', NULL, nan, nan, NULL, nan, NULL, NULL, 'ENST00000355585', 'BI', NULL, 0.0, 'YES', 'SYNJ2', 'Yes', '0;1', 'NM_003898.4', '1', 'G', 'p.Arg376His', 'SYNJ2', 0.0, NULL, 'O15056-1', 'HGNC', 'deleterious(0.01)', 'SNV', NULL, 'Transcript', nan, 9.962e-05, 'Somatic', nan, 'MODERATE', 'TCCACGGTGAG', 9.962e-05, 0.0, '+', 'TCGA-02-2470-01A', 0.0, 'TCGA-02-2470-01A-01D-1494-08', nan, NULL, NULL, NULL, 'ENST00000355585', 'O15056.196', NULL, 'PROSITE_profiles:PS50275;PANTHER:PTHR11200:SF148;PANTHER:PTHR11200', 'muse;mutect2;varscan2', NULL, nan, 'chr6', nan), ('060c15c0-25ca-4464-8aa3-364396b9b34c', 'CCDS3074.1', 'rs1347456083', NULL, NULL, False, NULL, NULL, 'UPI0000223E4E', 'T', 'TCGA-05-4382-10A-01D-1265-08', 17, 'TCGA-05-4382-10A-01D-1265-08', nan, 'missense_variant', 'Yes', NULL, 86, 'Unknown', nan, '0;1', NULL, 0.0, '1', 'gnomAD_SAS', 160, NULL, NULL, NULL, 'HGNC:30211', '20e316a4-d1e4-44d2-881c-527e600203f0', 'T', NULL, 143, 'TCGA-05-4382', NULL, 'protein_coding', 'ENSG00000240303', 3.983e-06, 'SNP', NULL, 132642118, 0.0, nan, NULL, NULL, '391/2343', NULL, 132642118, NULL, '4/20', 'benign(0.207)', 'p.D131N', 0.0, '43b8f335-bb32-45de-985a-85508048b237', NULL, 'Bronchus and lung', '4/20', 'Gat/Aat', NULL, 'ACAD11,missense_variant,p.D131N,ENST00000264990,NM_032169.5,c.391G>A,MODERATE,YES,deleterious(0.04),benign(0.207),-1;ACAD11,missense_variant,p.D131N,ENST00000481970,,c.391G>A,MODERATE,,tolerated(0.05),benign(0.422),-1;NPHP3-ACAD11,downstream_gene_variant,,ENST00000632629,,,MODIFIER,YES,,,-1;ACAD11,intron_variant,,ENST00000489991,,n.461-11560G>A,MODIFIER,,,,-1;ACAD11,missense_variant,p.D131N,ENST00000485198,,c.391G>A,MODERATE,,deleterious(0.03),benign(0.422),-1;NPHP3-ACAD11,3_prime_UTR_variant,,ENST00000471702,,c.*2217G>A,MODIFIER,,,,-1;ACAD11,non_coding_transcript_exon_variant,,ENST00000496418,,n.289G>A,MODIFIER,,,,-1;ACAD11,non_coding_transcript_exon_variant,,ENST00000469042,,n.722G>A,MODIFIER,,,,-1;HSPA8P19,upstream_gene_variant,,ENST00000505359,,,MODIFIER,YES,,,1', 'NM_032169.5', NULL, nan, 'No', 'TCGA-05-4382-10A', NULL, NULL, '879297cc-5afe-48aa-9a38-e8b1c6fe0a32', NULL, NULL, NULL, NULL, 'TCGA-LUAD', NULL, 'missense_variant', 'Yes', 'GRCh38', 'Missense_Mutation', '131/780', 'ENSP00000264990', NULL, NULL, NULL, 'c.391G>A', 'D/N', 84129, '449/3231', NULL, 'f0be1c9e-728c-4655-b792-96bfe1cd5344', NULL, '3434b91a-c05f-460f-a078-7b1bb6e7085d', 'rs1347456083;COSV99391730', 'TCGA-05-4382-01A-01D-1931-08', NULL, 'P1', NULL, '1', 'C', NULL, nan, nan, NULL, nan, NULL, NULL, 'ENST00000264990', 'BI', NULL, 0.0, 'YES', 'ACAD11', 'Yes', '0;1', 'NM_032169.5', '-1', 'C', 'p.Asp131Asn', 'ACAD11', 3.268e-05, NULL, 'Q709F0-1', 'HGNC', 'deleterious(0.04)', 'SNV', NULL, 'Transcript', nan, 0.0, 'Somatic', nan, 'MODERATE', 'TAAATCACGGA', 3.268e-05, 0.0, '+', 'TCGA-05-4382-01A', 0.0, 'TCGA-05-4382-01A-01D-1931-08', nan, NULL, NULL, NULL, 'ENST00000264990', 'Q709F0.150', NULL, 'CDD:cd05154;PANTHER:PTHR45741;Gene3D:3.90.1200.10;Pfam:PF01636;Superfamily:SSF56112', 'muse;mutect2;varscan2', NULL, nan, 'chr3', nan), ('b9f53be3-dd39-425a-bc30-b9175c3ba470', 'CCDS46919.1', 'rs774702840', NULL, NULL, False, 'COSM6096154;COSM6096155', NULL, 'UPI000020A292', 'A', 'TCGA-05-4403-10A-01D-1265-08', 7, 'TCGA-05-4403-10A-01D-1265-08', 0.0, 'missense_variant', 'Yes', NULL, 100, 'Unknown', 0.0, '0;1', NULL, 0.0, '1', 'gnomAD_EAS', 50, NULL, NULL, NULL, 'HGNC:17008', 'a17b5d32-f570-4d2d-9e97-f8b01de1be9f', 'A', NULL, 43, 'TCGA-05-4403', NULL, 'protein_coding', 'ENSG00000163781', 8.033e-06, 'SNP', NULL, 133644096, 2.903e-05, 0.0, NULL, NULL, '1772/4569', NULL, 133644096, 'amr', '11/28', 'benign(0.362)', 'p.A591V', 5.564e-05, '7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f', NULL, 'Bronchus and lung', '11/28', 'gCg/gTg', NULL, 'TOPBP1,missense_variant,p.A586V,ENST00000642236,NM_001363889.2,c.1757C>T,MODERATE,,deleterious(0.02),benign(0.286),-1;TOPBP1,missense_variant,p.A591V,ENST00000260810,NM_007027.4,c.1772C>T,MODERATE,YES,deleterious(0.02),benign(0.362),-1;TOPBP1,downstream_gene_variant,,ENST00000511439,,,MODIFIER,,,,-1;TOPBP1,downstream_gene_variant,,ENST00000509162,,,MODIFIER,,,,-1', 'NM_007027.4', NULL, 0.00019878099556080997, 'No', 'TCGA-05-4403-10A', NULL, NULL, '9ff327bf-3a69-4255-9504-10d14725eeb4', NULL, NULL, NULL, NULL, 'TCGA-LUAD', NULL, 'missense_variant', 'Yes', 'GRCh38', 'Missense_Mutation', '591/1522', 'ENSP00000260810', NULL, NULL, NULL, 'c.1772C>T', 'A/V', 11073, '1952/5761', NULL, '735d5588-a4b3-432f-a7cd-ea3da470a9cb', NULL, 'ce15f31f-2bad-4485-96fa-495bfa262e66', 'rs774702840;COSV53443193', 'TCGA-05-4403-01A-01D-1265-08', NULL, 'P4', NULL, '1', 'G', NULL, 0.0, 2.7046400646213442e-05, NULL, 0.00019878099556080997, NULL, NULL, 'ENST00000260810', 'BI', NULL, 0.0, 'YES', 'TOPBP1', 'Yes', '0;1', 'NM_007027.4', '-1', 'G', 'p.Ala591Val', 'TOPBP1', 0.0, NULL, NULL, 'HGNC', 'deleterious(0.02)', 'SNV', NULL, 'Transcript', 1.543019970995374e-05, 0.0, 'Somatic', 0.0, 'MODERATE', 'AATCCGCAACA', 5.564e-05, 0.0, '+', 'TCGA-05-4403-01A', 0.0, 'TCGA-05-4403-01A-01D-1265-08', 0.0, NULL, NULL, NULL, 'ENST00000260810', 'Q92547.185', NULL, 'PDB-ENSP_mappings:3uen.A;PDB-ENSP_mappings:3ueo.A;PDB-ENSP_mappings:3ueo.B;PDB-ENSP_mappings:3ueo.C;PDB-ENSP_mappings:3ueo.D;PDB-ENSP_mappings:6rmm.A;PDB-ENSP_mappings:6rmm.B;PDB-ENSP_mappings:6rmm.C;PDB-ENSP_mappings:6rmm.D;PROSITE_profiles:PS50172;CDD:cd17749;PANTHER:PTHR13561;Gene3D:3.40.50.10190;SMART:SM00292', 'muse;mutect2;varscan2', NULL, 0.0, 'chr3', 0.0), ('6eb276cd-f2bb-4620-bcaa-86681e8f01c9', 'CCDS33736.1', 'rs758836437', NULL, NULL, False, 'COSM6097768', NULL, 'UPI0000209BDA', 'T', 'TCGA-05-4410-10A-01D-1855-08', 36, 'TCGA-05-4410-10A-01D-1855-08', 0.0, 'missense_variant', 'Yes', NULL, 118, 'Unknown', 0.0, '0;1', NULL, 0.0, NULL, 'gnomAD_EAS', 149, NULL, NULL, NULL, 'HGNC:10582', 'e76567fb-2172-446f-87d3-afc4d7ef2b76', 'T', NULL, 113, 'TCGA-05-4410', NULL, 'protein_coding', 'ENSG00000185313', 1.193e-05, 'SNP', '1', 38726955, 0.0, 0.0, NULL, NULL, '2738/5871', NULL, 38726955, NULL, '17/28', 'probably_damaging(1)', 'p.A913D', 0.0001631, 'f85d0d42-436b-4251-a7fd-7d0f5fddd397', NULL, 'Bronchus and lung', '17/28', 'gCc/gAc', NULL, 'SCN10A,missense_variant,p.A922D,ENST00000655275,,c.2765C>A,MODERATE,YES,deleterious(0),probably_damaging(0.999),-1;SCN10A,missense_variant,p.A913D,ENST00000449082,,c.2738C>A,MODERATE,,deleterious(0),probably_damaging(1),-1;SCN10A,missense_variant,p.A913D,ENST00000643924,NM_001293306.2,c.2738C>A,MODERATE,,deleterious(0),probably_damaging(1),-1;SCN10A,missense_variant,p.A913D,ENST00000643108,,c.2738C>A,MODERATE,,deleterious(0),probably_damaging(1),-1;SCN10A,missense_variant,p.A913D,ENST00000644826,NM_001293307.2&NM_006514.3,c.2738C>A,MODERATE,,deleterious(0),probably_damaging(1),-1', NULL, NULL, 0.0, 'No', 'TCGA-05-4410-10A', NULL, NULL, '3050678f-ea4a-419a-9553-ade8d2411e88', NULL, NULL, NULL, NULL, 'TCGA-LUAD', NULL, 'missense_variant', 'Yes', 'GRCh38', 'Missense_Mutation', '913/1956', 'ENSP00000390600', NULL, NULL, NULL, 'c.2738C>A', 'A/D', 6336, '2951/6626', NULL, 'bf59c091-609d-431f-8966-64eaea595038', NULL, 'd28e465c-e553-4c53-8bb7-3d8199b9a8a5', 'rs758836437;COSV71862234', 'TCGA-05-4410-01A-21D-1855-08', NULL, 'P4', NULL, '1', 'G', NULL, 0.00020145000598859042, 6.757939900126075e-06, NULL, nan, NULL, NULL, 'ENST00000449082', 'BI', NULL, 0.0, NULL, 'SCN10A', 'Yes', '0;1', NULL, '-1', 'G', 'p.Ala913Asp', 'SCN10A', 0.0, NULL, NULL, 'HGNC', 'deleterious(0)', 'SNV', NULL, 'Transcript', 0.0, 0.0, 'Somatic', 0.0, 'MODERATE', 'CCAGGGCCACC', 0.0001631, 0.0, '+', 'TCGA-05-4410-01A', 0.0, 'TCGA-05-4410-01A-21D-1855-08', 0.0, NULL, NULL, NULL, 'ENST00000449082', 'Q9Y5Y9.161', NULL, 'Pfam:PF06512;PANTHER:PTHR10037;PANTHER:PTHR10037:SF208', 'muse;mutect2;varscan2', NULL, 0.0, 'chr3', 0.0);