text:   degeneracy: Improving population models of neurons",3,"['Which ion channel parameters from a huge theoretically possible parameter space are present in real neurons? In our preprint, we propose that Pareto optimality can serve as a guiding principle for addressing this issue (known as ion channel degeneracy). <LINK>', 'Pareto optimality could help find models with optimal ion channel configurations performing best for a trade-off between energy efficiency and functional effectiveness. This could reduce the high-dimensional parameter space to geometrically simple low-dimensional manifolds.', 'Pareto optimality might provide insights into neuronal ion channel correlations (e.g., in Patch-seq data). Multi-objective Pareto optimality has been applied to biology by Uri Alon https://t.co/5iyPRK41pr. See also a great review by @DiesPallas et al. https://t.co/2aWYVYofci']",22,03,777