Heterocyclylaminoalkyl Substituted Benzimidazoles Inhibitors of RSV replication of formula (I): The salts and stereochemically isomeric forms thereof, wherein Q is hydrogen, C1-6alkyl optionally substituted with a heterocycle or Q is C1 -6alkyl substituted with both -OR4 and a heterocycle; wherein said heterocycle is oxazolidine, thiazolidine, 1-oxo-thiazolidine, 1,1-dioxothiazolidine, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, hexahydrooxazepine, hexahydrothiazepine, 1-oxo-hexahydrothiazepine, 1,1-dioxo-hexahydrothiazepine, pyrrolidine, piperidine, homopiperidine, piperazine; which heterocyle may be substituted with 1-2 substituents; each Alk is C1 -6alkanediyl; R1 is Ar or optionally substituted piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazo lyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyl or 2,3-dihydro-1,4-dioxino[2,3-b]pyridyl; R3 is hydroxyC1 -6alkyl, C1 -6alkoxyC1-6alkyl, cyanoC1-6alkyl, aminocarbonyl-C1 -6-alkyl, mono-or di(C1 -6alkyl)aminocarbonyl-C1 -6- alkyl, carboxyl-C1 -6-alkyl, C1-6alkoxycarbonyl-C1-6 alkyl; R2, R4 and R5 are hydrogen or C1-6alkyl; Het is pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazo lyl, benzthiazolyl, pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]- pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyl and 2,3-dihydro-1,4- dioxino[2,3-b]pyridyl; Ar is optionally substituted phenyl; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).
Output: Inhibidores de benzimidazoles sustituidos con heterociclilaminoalquilo de replicacion de RSV de formula (I) (ver formula (I)) sus sales o sus formas estereoquimicamente isomericas de los mismos, en donde Q es hidrogeno, alquilo de C1-6 opcionalmente sustituido con un heterociclo o Q es alquilo de C1-6 sustituido con ambos un radical -OR6 y un heterociclo; en donde dicho heterociclo es oxazolidina, tiazolidina, 1-oxo-tiazolidina, 1,1-dioxotiazolidina, morfolinilo, tiomorfolinilo, 1-oxo-tiomorfolinilo, 1,1-dioxotiomorfolinilo, hexahidrooxazepina, hexahidrotiazepina, 1-oxo-hexahidrotiazepina, 1,1-dioxo-hexahidrotiazepina, pirrolidina, piperidina, homopiperidina, piperazina; en donde dicho heterociclo se puede sustituir con 1-2; cada Alq es alcanodiilo de C1-6; R1 es Ar o piperidinilo, piperazinilo, morfolinilo, tiomorfolinilo, piridilo, pirazinilo, piridazinilo, pirimidinilo, furanilo, tetrahidrofuranilo, tienilo, pirrolilo, tiazolilo, oxazolilo, imidazolilo, isotiazolilo, pirazolilo, isoxazolilo, oxadiazolilo, quinolinilo, quinoxalinilo, benzofuranilo, benzotienilo, benzimidazolilo, benzoxazolilo, benztiazolilo, piridopiridilo, naftiridinilo, 1H-imidazo[4,5-b]-piridinilo, 3H-imidazo[4,5-b]-pir idinilo, imidazo[1,2-a]piridinilo o 2,3-dihidro-1,4-dioxino[2,3-b] piridilo; R3 es hidroxialquilo de C1-6 alcoxi C1-6alquilo C1-6, cianoalquilo de C1-6, aminocarbonil-alquilo de C1-6, mono o di(alquilo C1-6)aminocarbonil-alquilo de C1-6, carboxil-alquilo de C1-6, alcoxi C1-6-carbonil-alquilo de C1-6; R2, R4 y R5 son hidrogeno o alquilo de C1-6; Het es piridilo, pirazinilo, piridazinilo, pirimidinilo, furanilo, tetrahidrofuranilo, tienilo, pirrolilo, tiazolilo, oxazolilo, imidazolilo, isotiazolilo, pirazolilo, isoxazolilo, oxadiazolilo, quinolinilo, quinoxalinilo, benzofuranilo, benzotienilo, benzimidazolilo, benzoxazolilo, benztiazolilo, piridopiridilo, naftiridinilo, 1H-imidazo[4,5-b]piridinilo, 3H-imidazo[4,5-b]-piridinilo, imidazo[1,2-a]piridinilo y 2,3-dihidro-1,4-dioxino[2,3-b]piridilo; Ar es fenilo opcionalmente sustituido; composiciones farmaceuticas que contienen compuestos (I) y procedimientos para la preparacion de compuestos (I).