niryuu/sni-each-converted huggingface dataset:
Both non-Group A streptococcal (non-GAS) pharyngitis and Group A streptococcal (GAS) pharyngitis are commonly found in patients with sore throat. It is not known whether or not they present with similar signs and symptoms compared to patients with non-streptococcal pharyngitis. MEDLINE was searched for prospective studies that reported throat culture for both GAS and non-GAS as a reference standard, and reported at least one sign, symptom, or the Centor score. Summary estimates of sensitivity, specificity, likelihood ratios (LR+ and LR-), and diagnostic odds ratios (DOR) were calculated using a bivariate random effects model. Summary receiver operating characteristic (ROC) curves were created for key signs and symptoms. Eight studies met our inclusion criteria. Tonsillar exudate had the highest LR+ for both GAS and non-GAS pharyngitis (1.53 versus 1.71). The confidence intervals of sensitivity, LR+, LR-, and DOR for all signs, symptoms, and the Centor score between two groups overlapped, with the relative difference between sensitivities within 15% for arthralgia or myalgia, fever, injected throat, tonsillar enlargement, and tonsillar exudate. Larger differences in sensitivities were observed for sore throat, cervical adenopathy, and lack of a cough, although the difference for lack of a cough largely due to a single outlier. Signs and symptoms of patients with GAS and non-GAS pharyngitis are generally similar. No signs or symptoms clearly distinguish GAS from non-GAS infection. Further work is needed to determine whether Group C streptococcus is a pathogen that should be treated.
Output: Centor criteria are used for which disease?
Kolding Stadion, nicknamed rneborgen by the local team's fanclub after Kolding FC's impressive home record of the 2005 autumn-season (just one loss).
Output: What team uses Kolding Stadion?
Chakka prathaman is a traditional payasam (pudding) of Kerala, India.
Output: The country for Chakka prathaman was what?
Restless legs syndrome/Willis Ekbom disease (RLS/WED) has been recognized as a significant medical disorder since the 17th century. It was studied mostly in the last 50 years in relation to increasing interest in sleep medicine and health-related quality of life. This led to recognition that the disease is not well characterized as restless feelings in the legs. These symptoms are reported in many situations, but the subjective experience of RLS/WED patients differs from that experienced by others. Thus a new name has been introduced that avoids problems of symptom definition of a disease by naming it after those who first characterized it, i.e. 'Willis Ekbom disease'. This article emphasizes the importance of RLS/WED for psychiatry. The disease carries significant increased risk for depression and anxiety disorders. Treatment requires consideration of these co-morbid disorders. RLS/WED can exacerbate or even engender psychiatric disease, so treatment of psychiatric disease should also include consideration of RLS/WED. The need for attention to RLS/WED is particularly significant for depression. Most anti-depressants exacerbate or can even engender RLS/WED. Thus this article seeks to introduce RLS/WED in relation to psychiatric practice. It presents the RLS/WED disease, its overlap with psychiatry and the current treatment options.
Output: Willis-Ekbom disease is also known as?
Rob Larter graduated from the University of Birmingham with a PhD in Geological Sciences in 1991.
Output: What college did Rob Larter go to?
Fulk Basset (died 4 May 1271) was archbishop of Dublin, and was the elder brother of John de Sandford who was also archbishop at one time.
Output: Who was the brother of Fulk Basset?
Gunnar Vada (born 16 March 1927 in Beitstad) is a Norwegian politician for the Conservative Party.
Output: What political party is Gunnar Vada a memeber of?
Associacao Cultural e Desportiva Potyguar Seridoense play their home games at Estadio Municipal Coronel Jose Bezerra.
Output: What is the home venue of Associação Cultural e Desportiva Potyguar Seridoense?
In follicular lymphoma, a chromosomal translocation commonly occurs between the fourteenth and the eighteenth chromosomes -- t(14;18) -- which places the Bcl-2 gene from chromosome 18 next to the immunoglobulin heavy chain locus on chromosome 14.
Output: Which chromosone can you find Bcl-2?
Freilassing station was opened in 1860 together with the railway line from Munich to Salzburg.
Output: When date was the official opening of Freilassing station?
Coming off their bye week, the Saints stayed at home for their Week 8 fight with the visiting Baltimore Ravens. From the get-go, New Orleans trailed as quarterback Steve McNair got a 5-yard touchdown run for the only score of the quarter. In the second quarter, things only got worse for the Saints, as McNair completed a 4-yard touchdown pass to WR Clarence Moore, while rookie DB Ronnie Prude returned an interception 12 yards for a touchdown. New Orleans would get on the board, as quarterback Drew Brees completed a 32-yard touchdown pass to WR Joe Horn, yet Baltimore would increase their lead with McNair completing a 6-yard touchdown pass to TE Todd Heap. In the third quarter, the Ravens got another 12-yard touchdown interception return with rookie Strong Safety Dawan Landry making the pick for the only score of the period. In the fourth quarter, the Saints tried to mount a comeback, as Brees completed a 47-yard touchdown pass and a 25-yard touchdown pass to rookie WR Marques Colston. However, the Saints comeback drive would end there, as New Orleans fell to 5-2.
Output: Who scored the only points in the third quarter?
The sperm and egg dont look anything like a human baby ( Figure 1.1). After they come together, they will develop into a human being. How does a single cell become a complex organism made up of billions of cells? Keep reading to find out. Sexual reproduction happens when a sperm and an egg cell combine together. This is called fertilization. Sperm are released into the vagina during sexual intercourse. They swim through the uterus and enter a fallopian tube. This is where fertilization normally takes place. A sperm that is about to enter an egg is pictured below ( Figure 1.1). If the sperm breaks through the eggs membrane, it will immediately cause changes in the egg that keep other sperm out. This ensures that only a single sperm can penetrate an egg. It will also cause the egg to go through meiosis. Recall that meiosis, cell division that creates the egg, begins long before an egg is released from an ovary. In fact, it begins prior to birth. The sperm and egg each have only half the number of chromosomes as other cells in the body. These cells are haploid, with a single set of chromosomes. This is because when they combine together, they form a cell with the full number of chromosomes. The cell they form is called a zygote. The zygote is diploid, with two sets of chromosomes, one from each parent. A human zygote has two sets of 23 chromosomes, for a total of 46 chromosomes (23 pairs). The zygote slowly travels down the fallopian tube to the uterus. As it travels, it divides by mitosis many times. It forms a hollow ball of cells. After the ball of cells reaches the uterus, it fixes itself to the side of the uterus. This is called implantation. It usually happens about a week after fertilization. Now the implanted ball of cells is ready to continue its development into a baby boy or girl.
Output: how do eggs develop?
James De La Vega was born in East Harlem, the son of Jaime De La Vega and Elsie Matos, and graduated valedictorian at York Preparatory School and attended Cornell University, where he graduated in 1994 with a Bachelor of Fine Arts.
Output: What is the name university that educated James De La Vega?
San Francisco kept Detroit in the game with missed opportunities, then made just enough plays for a rare two-game winning streak and its first road win. RB Frank Gore set a franchise record with 148 yards rushing in the first half and scored on a 61-yard run before leaving with a concussion. San Francisco led 13-3 at halftime after scoring on three of its first four drives, wishing it had a bigger lead after out gaining Detroit 247-102 yards and recovering a fumble without giving up a turnover. The 49ers had chances to go ahead big in the third quarter because Detroit had two turnovers on its first three plays, but they came away with only a field goal and a 13-point lead. Gore then caught a 7-yard pass, wobbled off the field and didn't return. QB Alex Smith's fumble midway through the third quarter set up a score that helped the Lions get back in the game. The 49ers drove down the field to set up K Joe Nedney's fourth field goal, a key score because it made Detroit go for a TD instead of kicking a tying field goal late in the game. S Keith Lewis intercepted QB Jon Kitna's pass at the 49ers' 2 with 2 minutes left and San Francisco now 4-5 picked up the one first down it needed to seal the game, winning consecutive games for the second time since 2003. RB Frank Gore finished with career-high 159 yards rushing and San Francisco's QB Alex Smith was 14 of 20 for 136 yards with a fumble. WR Arnaz Battle caught six passes for 55 yards, and converted a third-and-4 on the final drive to allow the 49ers to run out the clock. The 49ers' defense again came up huge, allowing only 273 total offensive yards and forcing 4 turnovers. LB Brandon Moore was yet again the story, leading the team with 9 tackles, 2 sacks and forcing 2 turnovers. With the win, the 49ers advanced to 4-5.
Output: Which player had a fumble in the third quarter, Alex Smith or Jon Kitna?
Palazzo Thiene Bonin Longare is a patrician palace in Vicenza, northern Italy, designed by Andrea Palladio probably in 1572 and built after Palladio's death by Vincenzo Scamozzi.
Output: Who created Palazzo Thiene Bonin Longare?
Transcription coupled repair (TCR) is a nucleotide excision repair (NER) pathway that is dedicated to repair in the transcribed strand of an active gene. The genome overall NER is called global genomic repair (GGR). Elc1, the yeast homolog of the mammalian elongation factor elongin C, has been shown to be a component of a ubiquitin ligase complex that contains Rad7 and Rad16, two factors that are specifically required for GGR. Elc1 has also been suggested to be present in another ubiquitin ligase complex that lacks Rad7 and Rad16 and is involved in UV-induced ubiquitylation and subsequent degradation of RNA polymerase II. Here we show that elc1 deletion increases UV sensitivity of TCR-deficient cells but does not affect the UV sensitivity of otherwise wild type and GGR-deficient cells. Cells deleted for elc1 show normal NER in the transcribed strand of an active gene but have no detectable NER in the non-transcribed strand. Elc1 does not affect UV-induced mutagenesis when TCR is operative, but plays an important role in preventing the mutagenesis if TCR is defective. Furthermore, the levels of Rad7 and Rad16 proteins are not significantly decreased in elc1 cells, and overexpression of Rad7 and Rad16 individually or simultaneously in elc1 cells does not restore repair in the non-transcribed strand of an active gene. Our results suggest that Elc1 has no function in TCR but plays an important role in GGR. Furthermore, the role of Elc1 in GGR may not be subsidiary to that of Rad7 and Rad16.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
The Flute sonata in E minor (HWV 379) was composed (circa 1727-28) by George Frideric Handel for flute and keyboard (harpsichord).
Output: What is the musical instrument Flute sonata in E minor (HWV 379) was intended for?
A heat wave is different depending on its location. According to the World Meteorological Organization, a region is in a heat wave if it has more than five consecutive days of temperatures that are more than 9 F (5 C) above average. Heat waves have increased in frequency and duration in recent years. The summer 2011 North American heat wave brought record temperatures across the Midwestern and Eastern United States. Many states and localities broke records for temperatures and for most days above 100 F. A high pressure cell sitting over a region with no movement is the likely cause of a heat wave. What do you think caused the heat wave in the image below (Figure 1.1)? A high pressure zone kept the jet stream further north than normal for August. A heat wave over the United States as in- dicated by heat radiated from the ground. The bright yellow areas are the hottest and the blue and white are coolest. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL: Droughts also depend on what is normal for a region. When a region gets significantly less precipitation than normal for an extended period of time, it is in drought. The Southern United States is experiencing an ongoing and prolonged drought. Drought has many consequences. When soil loses moisture it may blow away, as happened during the Dust Bowl in the United States in the 1930s. Forests may be lost, dust storms may become common, and wildlife are disturbed. Wildfires become much more common during times of drought.
Output: wildfires are increasingly common in the western united states due to an extended
Brasil Telecom's stock is traded on BM&F Bovespa, where it is part of the Ibovespa index, as well as on the New York Stock Exchange.
Output: Which exchange is Brasil Telecom on?
Facioscapulohumeral dystrophy (FSHD) is a progressive muscular dystrophy caused by decreased epigenetic repression of the D4Z4 macrosatellite repeats and ectopic expression of DUX4, a retrogene encoding a germline transcription factor encoded in each repeat. Unaffected individuals generally have more than 10 repeats arrayed in the subtelomeric region of chromosome 4, whereas the most common form of FSHD (FSHD1) is caused by a contraction of the array to fewer than 10 repeats, associated with decreased epigenetic repression and variegated expression of DUX4 in skeletal muscle. We have generated transgenic mice carrying D4Z4 arrays from an FSHD1 allele and from a control allele. These mice recapitulate important epigenetic and DUX4 expression attributes seen in patients and controls, respectively, including high DUX4 expression levels in the germline, (incomplete) epigenetic repression in somatic tissue, and FSHD-specific variegated DUX4 expression in sporadic muscle nuclei associated with D4Z4 chromatin relaxation. In addition we show that DUX4 is able to activate similar functional gene groups in mouse muscle cells as it does in human muscle cells. These transgenic mice therefore represent a valuable animal model for FSHD and will be a useful resource to study the molecular mechanisms underlying FSHD and to test new therapeutic intervention strategies.
Output: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
Seymour College is an independent, Uniting Church, day and boarding school for girls, located at Glen Osmond, a suburb 5 km from the Central Business District of Adelaide, South Australia.
Output: In which country is Seymour College located?
When you look at the prickly cactus pictured below ( Figure 1.1), does the word "ouch" come to mind? Touching the cactus would be painful. Touch is the sense of pain, pressure, or temperature. Touch depends on sensory neurons, or nerve cells, in the skin. The skin on the palms of the hands, soles of the feet, and face has the most sensory neurons and is especially sensitive to touch. The tongue and lips are very sensitive to touch as well. Neurons that sense pain are also found inside the body in muscles, joints, and organs. If you have a stomach ache or pain from a sprained ankle, its because of these sensory neurons found inside of your body. The following example shows how messages about touch travel from sensory neurons to the brain, as well as how the brain responds to the messages. Suppose you wanted to test the temperature of the water in a lake before jumping in. You might stick one bare foot in the water. Neurons in the skin on your foot would sense the temperature of the water and send a message about it to your central nervous system. The frontal lobe of the cerebrum would process the information. It might decide that the water is really cold and send a message to your muscles to pull your foot out of the water. In some cases, messages about pain or temperature dont travel all the way to and from the brain. Instead, they travel only as far as the spinal cord, and the spinal cord responds to the messages by giving orders to the muscles. This allows you to respond to pain more quickly. When messages avoid the brain in this way, it forms a reflex arc, like the one shown below ( Figure 1.2). Our sense of touch is controlled by a huge network of nerve endings and touch receptors. This system is responsible for all the sensations we feel, including cold, hot, smooth, rough, pressure, tickle, itch, pain, vibrations, and more. There are four main types of receptors: mechanoreceptors, thermoreceptors, pain receptors, and proprioceptors. Mechanoreceptors perceive sensations such as pressure, vibrations, and texture. Your brain gets an enormous amount of information about the texture of objects through your fingertips because the ridges that make up your fingerprints are full of these sensitive receptors. Thermoreceptors perceive sensations related to the temperature of objects. There are two basic categories of thermoreceptors: hot receptors and cold receptors. The highest concentration of thermoreceptors can be found in the face and ears. Pain receptors, or nociceptor detect pain or stimuli that can or does cause damage to the skin and other tissues of the body. There are over three million pain receptors throughout the body, found in skin, muscles, bones, blood vessels, and some organs. Proprioceptors detect the position of different parts of the body in relation to each other and the surrounding environment. These receptors are found in joints, tendons and muscles, and allow us to do fundamental things such as feeding or clothing ourselves.
Output: which receptors allow us to do fundamental activities?
Five or six years ago, I attended a lecture on the science of attention. A professor who conducts research over in the medical school was talking about attention blindness, the basic feature of the human brain that, when we concentrate on one task, causes us to miss just about everything else. Because we can't see what we can't see, our lecturer was determined to catch us in the act. He had us watch a video of six people tossing basketballs back and forth, three in white shirts and three in black, and our task was to keep track only of the tosses among the people in white. The tape rolled, and everyone began counting. Everyone except me. I'm dyslexic , and the moment I saw that tape with the confusing basketball tossers, I knew I wouldn't be able to keep track of their movements, so I let my mind wander. I became curious, though, when about 30 seconds into the tape, a gorilla walked in among the players. She (we later learned a female student was in the gorilla suit) stared at the camera, beat her chest with her fist, and then went away while they continued passing the balls. When the tape stopped, the professor asked how many people had counted at least a dozen basketball tosses. Hands went up all over. He then asked who had counted 13, 14, and congratulated those who'd scored the perfect 15. Then he asked, "And who saw the gorilla?" I raised my hand and was surprised to discover I was the only person at my table and one of only three or four in the large room to do so. He'd set us up, trapping us in our own attention blindness. Yes, there had been a trick, but he wasn't the one who had played it on us. By concentrating so hard on counting, we had managed to miss the gorilla in the midst. Attention blindness is the fundamental organizing principle of the brain, and I believe that it presents us with a great opportunity. My take is different from that of many neuroscientists: Where they see the shortcomings of the individual, I sense an opportunity for cooperation. Fortunately, given the interactive nature of most of our lives in the digital age, we have the tools to control our different forms of attention and take advantage of them. It's not easy to admit that everything we've learned about how to pay attention means that we've been missing everything else. It's not easy for us logical, intelligent, confident types to admit that the very key to our success -- our ability to discover a problem and solve it, an achievement obtained in all those years in school and beyond -- may be exactly what limits us. No one ever told us that our way of seeing left out everything else.
Output: What's the total number of basketball tosses by the players in white shirts in the video?
Two different subpathways play a role in removal of UV-induced cyclobutane pyrimidine dimers (CPDs) by nucleotide excision repair (NER). The relatively slow global genome repair subpathway operates on all CPDs irrespective of their position in the DNA, whereas the transcription-coupled repair subpathway is responsible for the rapid removal of CPDs from transcribed strands. In Saccharomyces cerevisiae, the RAD26 gene is implicated in transcription-coupled repair. However, transcription-coupled repair is not completely absent in rad26 mutants, and therefore other gene products are possibly involved in this subpathway. Based on in vitro experiments with purified components, the transcription elongation factor S-II appeared to be a candidate for a function in transcription-coupled repair. To investigate a possible role of S-II in transcription-coupled repair in vivo in yeast, S-II null mutations were introduced into various genetic backgrounds differing in NER capacity. UV sensitivity was not altered by disruption of the S-II gene in a RAD+ (NER proficient) strain, or in rad26 (impaired in efficient transcription-coupled repair), rad7 (lacking global genome repair), or rad7 rad26 (lacking global genome repair, but having residual transcription-coupled repair capacity) mutants. Moreover, S-II did not influence the repair rate on the transcribed strand of the RPB2 gene, either in repair-proficient or in rad7 rad26 backgrounds. Hence, transcription-coupled repair is fully functional in yeast cells lacking the gene encoding S-II. Furthermore, S-II is not required for the Rad26-independent residual transcription-coupled repair in vivo.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
The Horta Museum (French: Musee Horta, Dutch: Hortamuseum) is a museum dedicated to the life and work of the Belgian Art Nouveau architect Victor Horta and his time.
Output: Of what style is Horta Museum?
Rates of remission were examined in two controlled 12-week studies of sertraline and placebo for post-traumatic stress disorder (PTSD). The performance of three scales was evaluated: the self-rated Davidson Trauma Scale (DTS), and two interviewer scales: the Clinician Administered PTSD Scale (CAPS) and Clinical Global Impressions (CGI). Sertraline proved significantly superior to placebo with respect to remission on all three ratings. Rates of remission were very similar for all scales, ranging from 23.1-26.3% for sertraline and 13.9-14.9% for placebo. Traditional thresholds for the CAPS and DTS were tested relative to the CGI and to each other. The CAPS and DTS thresholds of < 20 and < 18 were found to be valid.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
The Brokenwood Mysteries is a New Zealand detective drama television series that premiered on Prime in 2014.
Output: What country did The Brokenwood Mysteries originate?
It had been some time since Jack had seen the old man.Over the phone ,his mother told him,"Mr.Belser died last night ,The funeral is Wednesday."Memories flashed through his mind like an old newsreel as he sat quietly remembering his childhood days. When Jack was very young ,his father died.Mr Belser,who lived in the same neighborhood with them,spent as much time as he could to make sure Jack had a man's influence in his life.He spent a lot of time teachimg Jack he thought what was important in his following life.If Mr.Belser hadn' taught him how to weave,he wouldn't be in this business now.So he promised his mother he would attend Mr.Belser's funeral. "You'd better not drive your car.It's a long way."his mother warned him. Busy as he was,he kept his word.Though tired from the earliest flight,Jack tried his best to help.Mr.Belser's funeral was small because he had no children of his own and most of his s had passed away. The night before he had to return home,Jack and his mother stopped by to see the old house Mr.Belser once lived.Now it belonged to him.He bought the house from one of his s. The house was exactly as he remembered.Every step held memories.Every picture,every piece of furniture... Jadk stopped suddenly. The box on his desk was gone!He once asked the old man what was inside.He just smiled and said it was the most valuable thing to him,though it almost cost nothing to others.He figured that someone from the Belser family had taken it ."I will never know what was so valuable to him."Jack thought disappotntedly. Three days later returning home from work,Jack discovered a small package in his mailbox. The handwriting was difficult to read,but the return address caught his attention."Mr.Harold Belser"it read. Jack couldn't wait to open it .Inside lay the familiar small box.His heart racing,Jack unlocked the box.Inside he found a gold pocket watch with these words engraved:"Jack,Thanks for your time!Harold Belser." "The thing he valued most was my time."Jack held the watch before his chest,tears filling his eyes.
Output: What did Mr.Belser teach Jack when he aws young?
(online: The Great Battle of Galicia - A study in strategy ) Map of the Battle of Rawa Rickard, J. (23 February 2001), Battle of Rava Ruska, 3-11 September 1914
Output: On what date did Battle of Rawa end?
It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -"if 70% of water is used for agriculture then that's what we should target" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal.
Output: What is the main idea of this passage?
The Chiefs took an early lead on a 30-yard pass from Tyler Thigpen to Mark Bradley. The Chiefs defense continued to show improvement in the red zone, limiting the Chargers to two field goals instead of two touch downs. At the end of the first half, Thigpen threw a pass to 34yard touchdown pass to Tony Gonzalez. However, the extra point snap was botched and an attempt at a quick pass failed. The Chargers controlled the second half better than the first, scoring two touchdowns and leading the Chiefs by 7 at the end of the fourth quarter. The Chiefs' final drive ended with a 3-yard touchdown pass to Gonzalez. A 1-point PAT would tie the game. However, Herm Edwards told Thigpen to go for two, explaining in a post-game interview that the defense was too beat up for overtime play. The resulting two-point conversion ended in an incomplete pass. The Chiefs lost by one point.
Output: Which team won the game?
The 1873 Victorian football season was an Australian rules football competition played during the winter of 1873.
Output: What's 1873 Victorian football season sport?
Britons spend as much as nearly five hours a week keeping their homes clean, a survey found. Kitchens are cleaned most often, while doing the oven and windows are the least popular jobs. In total, they spend just over PS1 billion a year on products to keep the dirt at bay -- almost PS40 per household. Market analyst Mintel found a clear division of labour. While the average Briton spends 4 hours, 40 minutes cleaning their home each week, men spend just 3 hours, 53 minutes compared to 5 hours, 25 minutes for women. And while seven in ten women say they do most of the cleaning, this falls to four in ten for men. Confirming many parents' feelings, only one in five adult children and over living at their parents' home helps with cleaning chores, with children under 18 doing even less. Last year, the household cleaning market was worth PS1.06 billion, which equates to annual spending of PS39.89 per household. Those looking for the cleanest homes in the country should head to Scotland, where people spend an average of five fours, 6 minutes, which is closely followed by East and West Midlands at five hours, 1 minute. In comparison, the least number of hours spent in cleaning is spent in the southeast/East Anglia at four hours, 18 minutes. The southwest and Wales stand at four hours, 46 minutes, the northwest four hours, 44 minutes, and Yorkshire and the Humber four hours, 21 minutes. According to Richard Caines, Mintel's senior household care analyst, men still lag women in the household cleaning stakes and spend on average an hour and a half less time cleaning their home, suggesting an opportunity for a campaign to encourage more cleaning by men to helpredressthis imbalance. The number of households that need cleaning is continuing to grow, but pressure on time from increasingly busy lives limits the number of hours people are willing or able to spend cleaning their homes. This means the market will see an increasing focus on easy-to-use, but effective hard surface cleaners and cleaning equipment. Such products can help encourage more cleaning to be done in less time, but as well as focusing on more convenient products, cleaning brands can also inject an element of fun into campaigns through encouraging a more shared approach that involves the whole family. This will also help to address the gender imbalance and get older children to make more of a contribution to cleaning.
Output: In which area do people spend the most time cleaning their home each week?
The t(9;22)(q34;q11) translocation leading to the Philadelphia (Ph) chromosome resulting in BCR-ABL gene fusion is associated with a poor prognosis in acute lymphoblastic leukemia (ALL). We studied the relation between t(9;22), determined by karyotype, fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR), and in vitro drug resistance, measured by the MTT assay, in precursor B-cell ALL at diagnosis. The findings in twenty-one Ph-positive (Ph+) childhood common/precursorB (c/preB) cases were compared with 254 Ph-negative (Ph-) ALL cases. A large range of LC(50) values was found within the Ph+ patients. Moreover, LC(50) values did not differ significantly between Ph+ and Ph- samples for prednisolone, dexamethasone, L-asparaginase, vincristine, anthracyclines, thiopurines, epipodophyllotoxins, and 4H00-ifosfamide, even after matching for important prognostic features (age, white blood cell count (WBC), and immunophenotype). Adult Ph+ (n = 12) ALL was more resistant to prednisolone (> 270-fold, P = 0.030), and displayed an overall tendency to resistance when compared to matched cases of Ph- (n = 15) adult precursor B-cell ALL. Within Ph+ ALL, in vitro prednisolone resistance increased significantly with age (P = 0.006). The expression of lung resistance protein (LRP), but not P-glycoprotein (P-gp) or multidrug resistance protein (MRP), was significantly higher in all Ph+ patients. Both childhood and adult Ph+ precursor B-cell ALL samples display a heterogeneous in vitro resistance profile, with relatively sensitive and resistant cases. The adult Ph+ samples, however, are generally more resistant compared to matched Ph- controls, reaching significance for prednisolone. The correlation of prednisolone resistance with age within the Ph+ cases might help explain the poorer prognosis of adult Ph+ ALL.
Output: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
1272 Gefion (1931 TZ1) is an asteroid from the asteroid belt discovered on 10 October 1931 by Reinmuth, K. at Heidelberg.
Output: What year was 1272 Gefion discovered?
Andromeda VIII (And VIII / 8) is a galaxy discovered in August 2003.
Output: When was Andromeda VIII first discovered?
Coming off a primetime victory over Cincinnati, the Colts flew to Reliant Stadium for an AFC South rematch with the Houston Texans. Heading into this game, Indianapolis had never lost a game to the Texans, winning their first 9 games against them. In the first quarter, the Colts got an early shock as RB Ron Dayne ran for a 3-yard touchdown and a 6-yard touchdown run. Indianapolis would respond with 37-yard touchdown pass from QB Peyton Manning to WR Marvin Harrison. In the second quarter, the Colts tied the game with Manning completing a 9-yard touchdown pass to WR Aaron Moorehead. However, Houston reclaimed its lead with QB David Carr's 3-yard touchdown pass to RB Vonta Leach. In the third quarter, Indianapolis crept closer with K Adam Vinatieri making a 33-yard field goal for the only score of the period. In the fourth quarter, the Texans responded with kicker Kris Brown's 42-yard field goal. Afterwards, the Colts tied the game with Manning hooking up with Harrison again on a 7-yard touchdown pass, Harrison's second of the game. However, Houston managed to pull off a huge upset with Kris Brown's game-winning 48-yard field goal as time expired, giving Indianapolis their first ever loss against them. With the loss, the Colts fell to 11-4. Colts QB Peyton Manning finished the game 21 of 27 for 205 yards passing with three touchdowns and Texans QB David Carr finished with 163 passing yards on completing 16 of 23 passes with one touchdown. Rookie RB Joseph Addai ran the ball 15 times for 100 yards and former Heisman Trophy winner Ron Dayne finished the game with 153 rushing yards on 32 carries. After this game, the Colts were now 11-4, having lost 4 of 6 after a 9-0 start and dropped to 4-4 on the road.
Output: Which team was in the lead in the second quarter?
Apollo 440 (alternately known as Apollo Four Forty or @440) are an English band formed in Liverpool in 1990.
Output: What city is the band Apollo 440 from?
Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we determined effects of the SGLT2 inhibitor empagliflozin (300 mg/kg of diet for 15 wk; corresponding to 60-80 mgkg(-1)day(-1)) in type 1 diabetic Akita mice that, opposite to streptozotocin-diabetes, upregulate renal SGLT2 expression. Akita diabetes, empagliflozin, and Akita + empagliflozin similarly increased renal membrane SGLT2 expression (by 38-56%) and reduced the expression of SGLT1 (by 33-37%) vs. vehicle-treated wild-type controls (WT). The diabetes-induced changes in SGLT2/SGLT1 protein expression are expected to enhance the BG-lowering potential of SGLT2 inhibition, and empagliflozin strongly lowered BG in Akita (means of 187-237 vs. 517-535 mg/dl in vehicle group; 100-140 mg/dl in WT). Empagliflozin modestly reduced GFR in WT (250 vs. 306 l/min) and completely prevented the diabetes-induced increase in glomerular filtration rate (GFR) (255 vs. 397 l/min). Empagliflozin attenuated increases in kidney weight and urinary albumin/creatinine ratio in Akita in proportion to hyperglycemia. Empagliflozin did not increase urinary glucose/creatinine ratios in Akita, indicating the reduction in filtered glucose balanced the inhibition of glucose reabsorption. Empagliflozin attenuated/prevented the increase in systolic blood pressure, glomerular size, and molecular markers of kidney growth, inflammation, and gluconeogenesis in Akita. We propose that SGLT2 inhibition can lower GFR independent of reducing BG (consistent with the tubular hypothesis of diabetic glomerular hyperfiltration), while attenuation of albuminuria, kidney growth, and inflammation in the early diabetic kidney may mostly be secondary to lower BG.
Output: Which protein does empagliflozin inhibit?
Salif Diallo (born 9 May 1957) is a Burkinabe politician who has been President of the National Assembly of Burkina Faso since 2015.
Output: What country did Salif Diallo come from?
A new study found that inner-city kids living in neighborhoods with more green space gained about 13% less weight over a two-year period than kids living among more concrete and fewer trees. Such findings tell a powerful story. The obesity epidemic began in the 1980s, and many people think it results from increased portion sizes and inactivity , but that can't be everything. Big Macs and TVs have been with us for a long time. "Most experts agree that the changes were related to something in the environment," says Thomas Glass of the Hopkins School of Public Health. That something could be a shrinking of the green. The new research, published in the American Journal of Preventive Medicine, isn't the first to associate greenery with better health, but it does get us closer to identifying what works and why. At its most straightforward, a green neighborhood simply means more places for kids to play -- which is important since time spent outdoors is one of the strongest links to children's activity levels. Glass warns that most studies don't necessarily prove a link between greenness and health, but they're helping _ action. In September the U.S. government approved the No Child Left Inside Act to encourage public initiatives aimed at exposing kids to the outdoors. Finding green space is, of course, not always easy, and you may have to work a bit to get your family a little grass and trees. If you live in a suburb or a city with good parks, take advantage of what's there. Your children in particular will love it -- and their bodies will thank you.
Output: According to the passage, what might cause children's inactivity?
Children who see their parents drunk are twice likely to get drunk themselves, a survey of young teenagers has suggested. Poor parental supervision also raises the chances of teenage drinking, said the Joesph Rowntree Foundation. If parents don't know where their children are on a Saturday night, or let them watch films of violence, they are more likely to have had an alcoholic drink. The survey also found the behavior of friends is also a powerful factor in drinking habits. The more time teenagers spend with friends, the more likely they are to drink alcohol. In this survey of 5,700 children aged 13 to 16, carried out by the Joseph Rowntree Foundation, researchers found that one in five wanted to have a drink by the time they were 14. By the age of 16, half of those questioned said they had been drunk. Pamela Bremner, scientist of the survey, said, "For the first time in the UK, this study shows what most influences young people's drinking behavior." "It found that the behavior of friends and family is the most common influential factor in determining how likely and how often a young person will drink alcohol." Don Shenker, Chief Executive of Alcohol Concern, said, "Government ministers must also look at some of the causes of why it is so easy for children to get alcohol, usually from the home." "Governments should look to see if they've done everything they can to help the large supermarkets from continuing to sell cheap alcohol which encourages more alcohol sales and therefore results in more alcohol being stored in the home." The Royal College of Physicians also said it was not surprising that being able to get alcohol easily was an important factor on current drinking problems and drunkenness of teenagers. A statement said, "This shows that the government needs to focus more attention on increasing the price of alcohol, and increasing education and national campaigns for both young people and their families on the dangers of alcohol."
Output: Who should be responsible for the fact that some teenagers formed the habit of drinking besides their parents and friends, according to Don Shenker?
Natascha Badmann is a professional triathlete from Switzerland and was the first European woman to win the Ironman Triathlon World Championship.
Output: Which country is Natascha Badmann a citizen of?
The Fiji crested iguana or Fijian crested iguana (Brachylophus vitiensis) is a critically endangered species of iguana native to some of the northwestern islands of the Fijiian archipelago, where it is found in dry forest.
Output: What is the conservation status of Fiji crested iguana?
The ZBD-97, or Type 97, has been in service with the PLA ground forces since 2006, in the armored units of the Guangzhou and Nanjing military regions.
Output: What year is ZBD-97 associated with?
Sami Mubarak Faraj Ba Owain commonly known as Sami Mubarak (Arabic: ; born 12 November 1991) is an Omani footballer who plays for Dhofar S.C.S.C. in the Oman Professional League.
Output: Which sports team is Sami Mubarak a member of?
The gene CLPB encodes protein Caseinolytic peptidase B protein homolog in human.
Output: Which species has the CLPB gene?
The Battle of Godfrey's Cottage is an episode in the British comedy series Dad's Army, which was originally transmitted on Saturday 8 March 1969.
Output: What series is The Battle of Godfrey's Cottage in?
Sigma Editions is an independent record label founded in 1998 by Rosy Parlane and Dion Workman (both ex-members of Thela).
Output: What year was Sigma Editions created in?
The 52nd government of Turkey (30 October 1995 -- 6 March 1996) was a caretaker coalition government formed by True Path Party (DYP) and Republican People's Party (CHP).
Output: What year did 52nd government of Turkey start?
Many disorders of the reproductive system are not sexually transmitted infections. They are not caused by pathogens, so they dont spread from person to person. They develop for other reasons. The disorders are different between males and females. In both genders, the disorders could cause a little discomfort, or they could cause death. Most common disorders of the male reproductive system involve the testes. For example, injuries to the testes are very common. In teenagers, injuries to the testes most often occur while playing sports. An injury such as a strike or kick to the testes can be very painful. It may also cause bruising and swelling. Such injuries do not usually last very long. Another disorder of the testes is cancer. Cancer of the testes is most common in males aged 15 to 35. It occurs when cells in the testes grow out of control. The cells form a lump called a tumor. If found early, cancer of the testes usually can be easily cured with surgery. Disorders of the female reproductive system may affect the vagina, uterus, or ovaries. They may also affect the breasts. One of the most common disorders is vaginitis. This is redness and itching of the vagina. It may be due to irritation by soap or bubble bath. Another possible cause of vaginitis is a yeast infection. Yeast normally grow in the vagina. A yeast infection happens when the yeast multiply too fast and cause symptoms. A yeast infection can be treated with medication. Bubble baths may be fun, but for women and girls they can cause irritation to the vagina. A common disorder of the ovaries is an ovarian cyst. A cyst is a sac filled with fluid or other material. An ovarian cyst is usually harmless, but it may cause pain. Most cysts slowly disappear and do not need treatment. Very large or painful cysts can be removed with surgery. Many teen girls have painful menstrual periods. They typically have cramping in the lower abdomen. Generally, this is nothing to worry about. Taking a warm bath or using a heating pad often helps. Exercise can help as well. A pain reliever like ibuprofen may also work. If the pain is severe, a doctor can prescribe stronger medicine to relieve the pain. The most common type of cancer in females is breast cancer. The cancer causes the cells of the breast to grow out of control and form a tumor. Breast cancer is rare in teens. It becomes more common as women get older. If breast cancer is found early, it usually can be cured with surgery.
Output: cancer of the testes is most common in males aged
In breast cancer the development of metastasis is a major turning point in the treatment and outcome of the disease. Throughout tumour development, and especially in the development of metastasis, epithelial mesenchymal transition takes place. During this transformation into a mesenchymal phenotype, the tumour cells undergo a series of structural changes. The loss of structural integrity and adoption of mesenchymal filaments enables cells to detach from the epithelial cell layer and metastasise. Keratins form the intermediate filaments of the cytoskeleton and provide scaffold structures within cells. During cancer progression the intermediate filaments are reorganised, and dramatic changes are seen in their protein components. Keratins K8, K18, K19 and vimentin are intermediate filament proteins with altered expression profiles during tumour development. We have used in vivo and in vitro models to analyse changes in intermediate filament proteins. Antibody-based methods were used to study K8 levels and proteomic analysis to profile the protein content of metastatic breast cancer cell variants. K8 expression declines as human breast tumours progress into an invasive phenotype. Analysis of IF proteins indicated altered expression profiles of K8, K18, K19 and vimentin, with K8, K18, K19 expressed in high levels in the T47D and MCF-7 cell lines, whereas the highly metastatic cell lines expressed lower levels of K8 and K18 and no detectable K19. Vimentin showed reverse expression profile with T47D and MCF-7 cells having no detectable vimentin expression whereas the highly metastatic MDA-MB-231 and MDA-MB-436 showed high levels. Analysis of acetylation status using specific antibodies suggested acetylation occurred within the central coiled domain in the MCF-7 and T47D cells. Inhibition of tumour growth by tissue factor (TF) shRNA resulted in a dramatic re-elevation of expression of K8 in xenographs of the highly metastatic MDA-MB-436 line. Intermediate filament expression alters during epithelial mesenchymal transition. Identified post translational modifications may play a role in alterations seen in the organisation, solubility and stability of these filaments. Epithelial mesenchymal transition can be reversed and an epithelial phenotype re-established.
Output: What are the structures formed when keratin molecules come together?
Lewy bodies and coarse Lewy neurites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions are present in the axonal processes of neurons.
Output: Which is the primary protein component of Lewy bodies?