niryuu/sni-each-converted huggingface dataset:
The War of Jenkins' Ear was a conflict between Britain and Spain lasting from 1739 to 1748, with major operations largely ended by 1742. Its unusual name, coined by Thomas Carlyle in 1858, refers to an ear severed from Robert Jenkins, a captain of a British merchant ship. There is no evidence of the stories that the severed ear was exhibited before the British Parliament. The seeds of conflict began with the separation of an ear from Jenkins following the boarding of his vessel by Spanish coast guards in 1731, eight years before the war began. Popular response to the incident was tepid until several years later when opposition politicians and the British South Sea Company hoped to spur outrage against Spain, believing that a victorious war would improve Britain's trading opportunities in the Caribbean. Also ostensibly providing the impetus to war against the Spanish Empire was a desire to pressure the Spanish not to renege on the lucrative asiento contract, which gave British slavers permission to sell slaves in Spanish America. The war resulted in heavy British casualties in North America. After 1742, the war was subsumed by the wider War of the Austrian Succession, which involved most of the powers of Europe. Peace arrived with the Treaty of Aix-la-Chapelle in 1748. From the British perspective, the war was notable because it was the first time that a regiment of colonial American troops was raised and placed "on the Establishment" - made a part of the regular British Army - and sent to fight outside North America.
Output: Of which did the asiento contract did NOT refer to, the Austrian Succession or the British slave sales in in Spanish America?
TransLink is urging customers to avoid non-essential travel today and to stay home where possible in the difficult weather conditions. TransLink chief executive officer Peter Strachan said bus and train services were continuing to run where possible, however all CityCat and CityFerry services had been cancelled until further notice. "These are extremely difficult conditions for South East Queensland---we are running essential services where possible but safety remains to be the most important," Mr Strachan said. "Severe weather and associated flooding has impacted on all modes of public transport, with bus, ferry and train services all impacted to varying degrees. "If you are planning to use public transport at anytime over the next few days, then I would recommend you check that your intended service is still running." Service disruptions for today include: l City network trains running hourly on all lines. l Bus diversions, delays and cancellations in some regions, particularly across Brisbane, Ipswich and the Sunshine Coast. l CityCat and CityFerry services cancelled. Queensland Rail Chief Executive Officer Paul Scurrah said rising waterways had closed some train lines, and road closures and damage to property throughout the South-East had contributed to a shortage of available rail employees. "We intend to run trains hourly on all lines, similar to the timetable we operate on Christmas Day. We will also be looking to run other additional services to meet demand as required. At this stage we will run services stopping at all stations which will depart at the same time on the hour, however, this is all subject to the weather conditions and the availability of traincrew." Mr Scurrah encouraged all customers to visit the Translink website for specific departure times for their station, and asked for patience in the event of delays. "Queensland Rail appreciates that reduced services may cause disruptions but it is simply unavoidable. We have a dedicated and experienced team monitoring the situation around the clock and will be working to reopen the network as soon as practicably possible," Mr Scurrah said. The latest service disruption information is available on the TransLink website www.translink.com.au.
Output: Which means of transport is NOT available during the special period?
Mutations in the alpha-synuclein gene have been linked to rare cases of familial Parkinson's disease (PD). Alpha-synuclein is a major component of Lewy bodies (LB), a pathological hallmark of PD. Transgenic mice and Drosophila expressing either wild-type or mutant human alpha-synuclein develop motor deficits, LB-like inclusions in some neurons, and neuronal degeneration. However, the relationship between abnormal aggregates of alpha-synuclein and human dopamine (DA) neuron degeneration remains unclear. In this report, we have investigated the influence of alpha-synuclein expression on DA neurons in primary culture of embryonic human mesencephalon. Two days after culture, human DA cells were transduced with wild-type or mutant human (Ala(53)Thr) alpha-synuclein adenoviruses and maintained for 5 days. Overexpression of mutant and wild-type human alpha-synuclein resulted in 49% (P<0.01) and 27% (P<0.05) loss of DA neurons, respectively, while not affecting viability of other cells in the culture. Overexpression of rat alpha-synuclein or GFP (green fluorescent protein) had no effect on DA neuron survival. Cytoplasmic inclusions of alpha-synuclein were detected immunohistochemically in DA cells transduced with mutant human alpha-synuclein, but not wild-type alpha-synuclein. These results show that overexpression of human alpha-synuclein, particularly the mutant form, can cause human DA neuron death, suggesting that alpha-synuclein may have a primary role in the pathogenesis of PD.
Output: Which is the primary protein component of Lewy bodies?
Emil Julius Gumbel (18 July 1891, Munich -- 10 September 1966, New York City) was a German mathematician and political writer.
Output: In what place did Emil Julius Gumbel die?
Officials in the Midwestern U. S. town of Joplin, Missouri, say the death from Sundays' big tornado reaches 116 and that search efforts continue for possible survivors trapped in rubble . Search and rescue teams are conducting their third sweep through the nearly 10 kilometer - long and one - kilometer wide area of destruction left by the tornado. They are working as quickly as possible while weather conditions remain relatively stable. More storms are forecast for the area. Joplin Fire Chief Mitch Randles said there are areas with large piles of rubble that might hold survivors. "We are still finding individuals. We did rescue seven individuals from underneath rubble yesterday and, of course, we are also finding dead folks as well." Said more folks and that is why we are doing these searches. We want to make every opportunity that we can to find everybody that is in the rubble and that has survived to this point." Randles said the current sweep involves a slower pace that previous searches and that he plans a fourth search, possibly on Wednesday, using specially trained dogs. "We are searching every structure that has been damaged or destroyed in a more in-depth manner, "he said." I have dogs and dog handlers coming from all over the country do help us in that effort." Joplin City Manager Mark Rohr said the Red Cross and other volunteer organizations are helping people who were left homeless by the tornado and that the Federal Emergency Management Agency, or FEMA, is on hand to help. "Joplin is a great city. We have suffered a great loss, "said Rohr." We will recover and we will recover strongly and we have a lot of help and a lot of volunteers to make that easier." The tornado that struck Joplin was classified by the Natioonal Weather Service as an F - 4, with winds of more than 300 kilometers per hour. It lasted only 20 minutes, but it killed more that 100 people, injured more than 400 others, and destroyed or heavily damaged some 2,000 homes, businesses, churches and a hospital. Authorities have registered more than 1,700 calls about missing people and they hope to _ most of those cases soon, as victims are identified and survivors come forth and reunite with loved ones. This was the worst tornado to strike the United States in 60 years. It was the latest in a wave of violent storms that have swept Midwestern and southern states in recent weeks, leaving more than 300 people dead an causing more than $2 billion dollars in damage.
Output: What kind of disaster  of this article is talking about?
The objective was to determine the composition of the Cystic Fibrosis (CF) Population attending specialist UK CF centres in terms of age, gender, age at diagnosis, genotype and ethnicity. With the planned introduction of the national CF screening programme in the UK, cystic fibrosis transmembrane regulator (CFTR) mutations were compared between different ethnic groups enabling a UK-specific frequency of mutations to be defined. Data were analysed from the patient biographies held in the UK CF Database (see www.cystic-fibrosis.org.uk). The currently registered population of 5,274 CF patients is 96.3% Caucasian with a male preponderance that significantly increases with age. The majority of the 196 non-Caucasian CF patients are from the Indian Subcontinent (ISC), of which one in 84 UK CF patients are of Pakistani origin. The commonest CFTR mutation, deltaF508, is found in 74.1% of all CF chromosomes. In the Caucasian CF population, 57.5% are deltaF508 homozygotes but the UK ISC CF population with only 24.7%, has significantly fewer deltaF508 homozygotes patients (95% confidence interval (CI) 0.2-0.4). The distribution of Caucasian patients with deltaF508/deltaF508, deltaF508/Other and Other/Other does not fit the expected distribution with a Hardy-Weinberg model unless those patients without a detected mutation are excluded (P<0.001). The UK CF Database has shown the UK CF population to have distinct characteristics separate from the North American and European CF Registries. The ISC group contains many mutations not recognised by current genetic analysis, and one in four ISC patients have no CFTR mutations identified. The CFTR analysis proposed for the screening programme would detect 96% of patients registered in the database, but is unlikely to achieve the desired >80% detection rates in the ethnic minority groups. Screen-positive, non-Caucasian infants without an identifiable CFTR mutation should be referred for a sweat test and genetic counselling when serum trypsinogen concentrations remain elevated after birth.
Output: Which is the most common CFTR mutation in Caucasians?
The TNF family member receptor activator for NF-B ligand (RANKL) and its receptors RANK and osteoprotegerin are key regulators of bone remodeling but also influence cellular functions of tumor and immune effector cells. In this work, we studied the involvement of RANK-RANKL interaction in NK cell-mediated immunosurveillance of acute myeloid leukemia (AML). Substantial levels of RANKL were found to be expressed on leukemia cells in 53 of 78 (68%) investigated patients. Signaling via RANKL into the leukemia cells stimulated their metabolic activity and induced the release of cytokines involved in AML pathophysiology. In addition, the immunomodulatory factors released by AML cells upon RANKL signaling impaired the anti-leukemia reactivity of NK cells and induced RANK expression, and NK cells of AML patients displayed significantly upregulated RANK expression compared with healthy controls. Treatment of AML cells with the clinically available RANKL Ab Denosumab resulted in enhanced NK cell anti-leukemia reactivity. This was due to both blockade of the release of NK-inhibitory factors by AML cells and prevention of RANK signaling into NK cells. The latter was found to directly impair NK anti-leukemia reactivity with a more pronounced effect on IFN- production compared with cytotoxicity. Together, our data unravel a previously unknown function of the RANK-RANKL molecule system in AML pathophysiology as well as NK cell function and suggest that neutralization of RANKL with therapeutic Abs may serve to reinforce NK cell reactivity in leukemia patients.
Output: To the ligand of which receptors does Denosumab (Prolia) bind?
The Redpath Museum is a museum of natural history belonging to McGill University and located on the university's campus at 859 Sherbrooke Street West in Montreal, Quebec, Canada.
Output: Which industry is Redpath Museum associated with?
On at least one occasion they succeeded and formed the Kingdom of Kurdistan, which lasted from September 1922 until July 1924.
Output: Which year did Kingdom of Kurdistan end?
A proton is one of three main particles that make up the atom. The other two particles are the neutron and electron. Protons are found in the nucleus of the atom. This is a tiny, dense region at the center of the atom. Protons have a positive electrical charge of one (+1) and a mass of 1 atomic mass unit (amu), which is about 1.67 1027 kilograms. Together with neutrons, they make up virtually all of the mass of an atom. Click image to the left or use the URL below. URL: Q: How do you think the sun is related to protons? A: The suns tremendous energy is the result of proton interactions. In the sun, as well as in other stars, protons from hydrogen atoms combine, or fuse, to form nuclei of helium atoms. This fusion reaction releases a huge amount of energy and takes place in nature only at the extremely high temperatures of stars such as the sun. All protons are identical. For example, hydrogen protons are exactly the same as protons of helium and all other elements, or pure substances. However, atoms of different elements have different numbers of protons. In fact, atoms of any given element have a unique number of protons that is different from the numbers of protons of all other elements. For example, a hydrogen atom has just one proton, whereas a helium atom has two protons. The number of protons in an atom determines the electrical charge of the nucleus. The nucleus also contains neutrons, but they are neutral in charge. The one proton in a hydrogen nucleus, for example, gives it a charge of +1, and the two protons in a helium nucleus give it a charge of +2. Protons are made of fundamental particles called quarks and gluons. As you can see in the Figure 1.1, a proton contains three quarks (colored circles) and three streams of gluons (wavy white lines). Two of the quarks are called up quarks (u), and the third quark is called a down quark (d). The gluons carry the strong nuclear force between quarks, binding them together. This force is needed to overcome the electric force of repulsion between positive protons. Although protons were discovered almost 100 years ago, the quarks and gluons inside them were discovered much more recently. Scientists are still learning more about these fundamental particles.
Output: the atoms of different elements have
This busy and popular hotel requires a Junior Chef. You will need to be energetic, enthusiastic with a minimum of five years' kitchen experience. You must assist the head and senior chefs in the creation of new dishes. Annual salaries range from 20,000 to 25,000 pounds. Please send or e-mail your CV to the Personnel Administrator Hydo Hotel, Mount Road Eastbourne BN207HZ eclaine.ward@hydrohotel.com. We are looking for a kitchen assistant willing to learn the day-to-day jobs in a professional kitchen environment. You must have a passion for cooking and basic understanding of spoken English. You will mainly be working for a well-known company and learn valuable cheffing skills. The salary will be based on experience but could start from 12,500 pounds to 14,000 pounds annually plus tips. Please forward your CV and a letter of recommendation. 01428644460 Kitchen Manager. Spirit Pub Company is looking for the best individuals to lead our kitchen teams through some very exciting new developments. As an experienced Kitchen Manager, you will play an important role in engaging the chef team by great leaderships to deliver excellent standards and guest satisfaction. We can offer a starting salary of up to 27,000 pounds plus a bonus worth an extra 2,000 pounds per year for the right candidates. If you have what it takes to join our company, please provide your CV with your application. 07044338313 Food Service Assistant, South East Food Service Assistant required. Salary starts from 15,000 pound to 20,000 pounds annually. We are seeking a General Assistant for a Care Home East Sussex. Assisting the Cook and kitchen team in the food preparation of freshly prepared meals, washing up and cleaning of all kitchen areas. Previous experience would be an advantage. 07044338228
Output: Which job probably offers the second highest salary?
The classical view of the molecular clock is based on interlocked transcriptional-translational feedback loops. Because a substantial fraction of the mammalian genome is expressed in a circadian manner, chromatin remodeling has been proposed to be crucial in clock function. Here we show that Lys4 (K4) trimethylation of histone H3 is rhythmic and follows the same profile as previously described H3 acetylation on circadian promoters. MLL1, a mammalian homolog of Drosophila trithorax, is an H3K4-specific methyltransferase implicated in transcriptional control. We demonstrate that MLL1 is essential for circadian transcription and cyclic H3K4 trimethylation. MLL1 is in a complex with CLOCK-BMAL1 and contributes to its rhythmic recruitment to circadian promoters and to H3 acetylation. Yet MLL1 fails to interact with CLOCK19, providing an explanation for this mutation's dominant negative phenotype. Our results favor a scenario in which H3K4 trimethylation by MLL1 is required to establish a permissive chromatin state for circadian transcription.
Output: Which is the histone residue methylated by MLL1?
Flumazenil is a competitive benzodiazepine antagonist that acts to reverse their sedative and hypnotic effects. It is indicated in the management of benzodiazepine overdose, but its role in the routine reversal of endoscopic conscious sedation has not been defined. Patients undergoing diagnostic upper endoscopy who received sedation with either diazepam or midazolam alone were given flumazenil 0.2 mg incrementally immediately following the procedure until awake. They were then asked to repeat three psychomotor tests measuring cognitive and motor skills, with their baseline scores compared with postprocedure scores over a 3-hour period. Full psychomotor function was restored to baseline values within 30 minutes after flumazenil in 79% of patients, with no differences in the reversal of psychomotor skill impairment observed between diazepam and midazolam sedation. There was no evidence of rebound sedation seen for up to 3 hours. No significant anterograde amnesia was evident in 78% of individuals. These results demonstrate that flumazenil's effects on reversing psychomotor impairment are similar when midazolam or diazepam are used for conscious sedation. However, the potential usefulness of routine flumazenil reversal of conscious sedation will require further evaluation of specific psychomotor performance skills (such as driving a car) before we lift the admonition against leaving the endoscopic suite unattended, driving a vehicle, or operating complicated machinery for several hours.
Output: Which drug should be used as an antidote in benzodiazepine overdose?
Below are Top 10 Scholarly Stars in America in 2011. It's not always about fame and fortune for these celebs - education is a priority in their lives. Find out what scholarly stars have earned degrees and diplomas or are returning to the classroom as you head back to school. No. 10: James Franco James has attended FOUR prestigious universities in his life: UCLA, New York University, Columbia University and Yale University. We hear he's is so serious about school, he missed the Oscar nominations to attend class! No. 9: Natalie Portman Natalie Portman is so Ivy League: she graduated from Harvard University in 2003, thanks to her parents, who she says always made sure she put her studies before her acting. No. 8: Haley Joel Osment When students at NYU heard Haley Joel would be joining them as a freshman in 2006, they chalked the campus' sidewalks with his famous Sixth Sense movie line: "I see dead people." No. 7: Emma Watson Although Emma Watson put her education on hold to wrap up the Harry Potter film series, in July 2011 she announced that she was going back to school at Brown University to complete her degree. No. 6: Dakota and Elle Fanning Celeb sisters Dakota and Elle Fanning are stars on screen and in class. Dakota was her high school's homecoming queen two years in a row while Elle, who still attends middle school, somehow manages to balance her acting career with math tests and gym class. No. 5: Mara Wilson Mara Wilson graduated from NYU in 2009. Mara, who played the adorable Nattie in Mrs. Doubtfire, eventually grew up and headed to New York to attend NYU's Tisch School of the Arts; she graduated in 2009. No. 4: Tyra Banks Tyra Banks is known for being a savvy businesswoman, but even the best could use some formal training. She enrolled in Harvard Business School in 2011 and even went so far as to live in a dorm with her fellow classmates! "We live in dorms," confirmed the TV star. "I have my own room but we share a kitchen, living room and study area. It's mandatory dorms. I freaked out. In the beginning I was like, 'Oh yes, I'm going to Harvard and I'll be at the Four Seasons down the street.' And they were like, 'Girl, you're living in dorms!'" No. 3: Shakira Singer Shakira is resting her hips and giving her brain a workout at UCLA, attending classes on the history of western civilization so she could "learn from the best". No. 2: Steven Spielberg Director Steven skipped getting a formal education to be an unpaid intern at Universal Studios, where he learned his tricks of the _ . But eventually he did go back and earned his film degree in 2002. No. 1: Danica McKellar Danica McKellar is a math whiz. She used to be known for starring as Winnie Cooper in the Wonder Years, but Danica is also a UCLA graduate, math whiz and education advocate who's written three best-selling books encouraging middle-school girls to have confidence and succeed in mathematics.
Output: How many stars referred to in the material studied or will go to UCLA?
Interleukin-6 (IL-6) is associated with prostate cancer morbidity. In several experimental models, IL-6 has been reported to have anti-apoptotic and pro-angiogenic effects. Siltuximab (CNTO 328) is a monoclonal anti-IL-6 antibody which has been successfully applied in several models representing prostate cancer. This study was designed to assess preliminary safety of siltuximab in patients with early prostate cancer. Twenty patients scheduled to undergo radical prostatectomy received either no drug or siltuximab (6mg/kg, five patients per group with administration once, two times, and three times prior to surgery). Blood samples were collected for pharmacokinetic and pharmacodynamic analyses. Expression of elements of IL-6 signaling pathways was analyzed in tumor tissue by immunohistochemistry. Gene analysis in tumor specimens was performed with the DASL array. No adverse events related to siltuximab were observed. Patients treated with siltuximab presented with higher levels of proliferation and apoptosis markers. Following a single dose, serum concentrations of siltuximab declined in a biexponential manner. This study revealed a decrease in phosphorylation of Stat3 and p44/p42 mitogen-activated protein kinases. In addition, gene expression analyses indicate down-regulation of genes immediately downstream of the IL-6 signaling pathway and key enzymes of the androgen signaling pathway. Preliminary safety of siltuximab is favorable. Future studies in which siltuximab could be combined with androgen-deprivation therapy and experimental therapies in advanced prostate cancer are justified.
Output: Which interleukin is blocked by Siltuximab?
1st Kings was an electoral district in the Canadian province of Prince Edward Island, which elected two members to the Legislative Assembly of Prince Edward Island from 1873 to 1993.
Output: The year that 1st Kings was created was?
Born in Belfast, Northern Ireland, the son of Thomas Megahey (a minister) and Beatrice (nee Walton), Leslie Megahey was educated at King Edward VI School in Lichfield.
Output: Which college or university is related with Leslie Megahey?
Ted van de Pavert (born 6 January 1992) is a Dutch professional footballer who currently plays as a centre back for De Graafschap.
Output: What is the team that Ted van de Pavert is associated with?
Jose Santiago Albarracin 1 (23 July 1800 - 20 April 1869 ) was an Argentine soldier who fought on the Unitarian side in many engagements in the Argentine Civil Wars, especially in the struggles against Chacho Penaloza.
Output: Which conflict was Santiago Albarracín a part of?
Originally, at the end of Nurhaci's reign, Hong Taiji got hold of the two White Banners, but after Lady Abahai's death, he switched his two banners with Dorgon and Dodo's two Yellow banners (Nurhaci gave his two Yellow Banners to the two).
Output: Who was the brother of Hong Taiji?
Selenoproteins contain the 21st amino acid selenocysteine which is encoded by an inframe UGA codon, usually read as a stop. In eukaryotes, its co-translational recoding requires the presence of an RNA stem-loop structure, the SECIS element in the 3 untranslated region of (UTR) selenoprotein mRNAs. Despite little sequence conservation, SECIS elements share the same overall secondary structure. Until recently, the lack of a significantly high number of selenoprotein mRNA sequences hampered the identification of other potential sequence conservation. In this work, the web-based tool SECISaln provides for the first time an extensive structure-based sequence alignment of SECIS elements resulting from the well-defined secondary structure of the SECIS RNA and the increased size of the eukaryotic selenoproteome. We have used SECISaln to improve our knowledge of SECIS secondary structure and to discover novel, conserved nucleotide positions and we believe it will be a useful tool for the selenoprotein and RNA scientific communities. SECISaln is freely available as a web-based tool at [Link]
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Rudolf Teschner (16 February 1922, Potsdam -- 23 July 2006, Berlin-Steglitz) was a German chess master and writer.
Output: What nationality of Rudolf Teschner?
Researchers from France and Italy discovered that Canadian parents are less strict with their children than mothers and fathers in France and Italy. "Our most important finding was the difference between Canadians and the others," said Professor Michel Claes,the lead author of the study."Canadians focus on independence and negotiation.On the other hand,Italians,for example,exercise more control.We found Canadians seem to focus on negotiation in case of a conflict." Claes said Canada,France and Italy were selected for the study because they share important cultural and social factors."We chose FrenchCanadians because they share the same language as France,and originally came from France and share certain values.Italy was included because it was considered to have similar,strong and important family values," he explained. The researchers examined the emotional ties between parents and their children by questioning 1,256 students aged 11 to 19 years old. Canadian students reported less control and more free actions,according to the study.Italian parents were stricter and French parents were somewhere in the middle. Claes explains that the differences lie in education in Canada,France and Italy. "North America has its own educational values,which promote individualization.Tolerance and comprehension are encouraged.Italy,on the other hand,promotes respect of authority,control,and the need for permission." he said. Children from all three countries described their mothers as warm and communicative.Italian and Canadian children had similar feelings about their fathers,and reported high levels of emotional ties.But French fathers were generally thought by their children to be more distant and cold. "We were surprised by this," Claes admitted."It seems as though the relationships between French mothers and their children were becoming closer over time,while fathers maintain a form of distance and coldness,which is more of a source of conflict in France than in the other countries."
Output: According to Michel Claes,what mainly leads to the differences in parentchildren relationships among Canada,France and Italy?
Vans, Keds, Dollies--they sound like the names of rock bands, but if you have teenagers, you'll know they're actually the latest in teenage footwear. But experts are now warning that the current shoe fashions will be causing teenagers discomfort in the short term and storing up years of foot, knee and back pain in the future. Here, the experts identify the problems caused by teenagers' shoe choice. KEDS/VANS Slip-on shoes with elastic sides are particularly popular among teenage boys-with Keds and Vans the most sought-after brands. The main problem is that they are just too flat--so flat that the heel, which strikes the ground first, also becomes damaged and painful. BALLET PUMPS The worst shoes of all are such light and thin dolly shoes. The problem is partly their flatness, as with Keds and Vans. However ballet pumps, which have no string or heel, have other specific problems. "As the shoe has no fastening device, it relies on the toes to keep the shoe on, causing an awkward gait ,this leads to short-and long-term problems such as calluses ,heel and knee pain." WEDGES AND STILETTOS These shoes can also cause problems with gait, They may look good, but the heels on these are so high they can force the wearer's body weight forward, making them very unstable. Teens who wear these shoes regularly are also in danger of joining those millions of women with constant back pain. SCHOOL SHOES So what do podiatrists have on their wish list, especially for everyday wear? Something in a natural, breathable fabric, with a string to hold it on, with a small heel and a deep toe-box that does not press the toes, such as Clark's, Marks & Spencer or Rhino. If your teen insists on wearing 'bad' shoes, get them some simple foot orthotics in the shoes. These support and correct the movement of the foot and, properly fitted by a podiatrist, can often transform their walk and halt the damage.
Output: Of all the shoes mentioned in the passage, which can cause the worst problems?
Steninge Palace (also known as Steninge Manor) is a Baroque palace overlooking Lake Malaren near Marsta outside of Stockholm, Sweden.
Output: What body of water was Steninge Palace next to?
The Raiders traveled across the bay to Monster Park in San Francisco to take on the 49ers. The 49ers got on the board first with an Alex Smith to Arnaz Battle touchdown pass midway through the first quarter. The Raiders responded with a 33-yard field goal by Sebastian Janikowski. Janikowski then converted a 36 yarder early in the second quarter. Randy Moss scored his 100th career touchdown reception on a 22-yard pass from Andrew Walter, as the Raiders went into halftime with a 13-7 lead. The 49ers then went on to score 24 unanswered points in the second half, as Smith connected on touchdown passes with Battle once again, and Maurice Hicks in the third quarter. Joe Nedney converted a chip shot 19-yard field goal early in the fourth quarter. On the next Raiders play from scrimmage, Melvin Oliver recovered a fumble for a touchdown, as Walter tried to lateral a pass to LaMont Jordan, who let it hit the ground, and assumed it was an incomplete pass. Marques Tuiasosopo hit Courtney Anderson with a touchdown pass late in the game, but it was too little too late. Nedney completed the scoring with a 39-yard field goal.
Output: Who scored first in the first quarter?
In the Night Garden In a magical forest, colourful characters have adventures. A mysterious tide of water appears suddenly next to Igglepiggle. He discovers that he can control it by moving his feet. Excited, he takes it to Makka Pakka who finds it very useful indeed. Children Under 5 Today on BBC2 from 11:05am to 11:35am Last of the Summer Wine To relax, Howard tries a simple trick to change his appearance enough to fool even Pearl. But he soon discovers that taking over someone else's identity can be equally dangerous. Comedy Sitcoms Today on G.O.L.D. from 12:40pm to 1: 20pm The Secret Circle Cassie is an orphaned teenager who discovers that not only is she a witch but that she is also the key that will unlock a centuries-old battle between good and evil. When Cassie accepts a cute boy's invitation to the school dance, Adam struggles to control his anger. Today on Sky Living from 10:00pm to 11:00pm The Kid's Speech Eleven-year-olds, Reggie and William, and 14-year-old Bethan, are determined to improve their speech. Along with their parents, they start a unique course at the Michael Palin Centre for Stammering children. Over two weeks, they open up about their fears and frustrations. Documentary Today on BBC1 London from 10:35pm to 11:25pm
Output: Which play can be used to inspire children who are afraid to speak in public?
Street Dogs are an American punk rock band from Boston, MA, formed in 2002 by former Dropkick Murphys singer Mike McColgan.
Output: In what year did Street Dogs originate?
Most fossils are preserved by one of five processes outlined below (Figure 1.1): Most uncommon is the preservation of soft-tissue original material. Insects have been preserved perfectly in amber, which is ancient tree sap. Mammoths and a Neanderthal hunter were frozen in glaciers, allowing scientists the rare opportunity to examine their skin, hair, and organs. Scientists collect DNA from these remains and compare the DNA sequences to those of modern counterparts. The most common method of fossilization is permineralization. After a bone, wood fragment, or shell is buried in sediment, mineral-rich water moves through the sediment. This water deposits minerals into empty spaces and Five types of fossils: (a) insect preserved in amber, (b) petrified wood (permineralization), (c) cast and mold of a clam shell, (d) pyritized ammonite, and (e) compression fossil of a fern. produces a fossil. Fossil dinosaur bones, petrified wood, and many marine fossils were formed by permineralization. When the original bone or shell dissolves and leaves behind an empty space in the shape of the material, the depression is called a mold. The space is later filled with other sediments to form a matching cast within the mold that is the shape of the original organism or part. Many mollusks (clams, snails, octopi, and squid) are found as molds and casts because their shells dissolve easily. The original shell or bone dissolves and is replaced by a different mineral. For example, calcite shells may be replaced by dolomite, quartz, or pyrite. If a fossil that has been replace by quartz is surrounded by a calcite matrix, mildly acidic water may dissolve the calcite and leave behind an exquisitely preserved quartz fossil. Some fossils form when their remains are compressed by high pressure, leaving behind a dark imprint. Compression is most common for fossils of leaves and ferns, but can occur with other organisms. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:
Output: the most common way that fossil leaves are made is by
Air Hong Kong (Chinese: ) is the only all-cargo airline based in Hong Kong, with its main hub at Hong Kong International Airport.
Output: What is the name of the airport associated with Air Hong Kong?
Most people today think of chocolate as something sweet to eat or drink and can be easily found in stores around the world. It might surprise you that chocolate was once highly treasured. The wealthy people of Spain first enjoyed a sweetened chocolate drink. Later, the popularity of the drink spread throughout Europe. Chocolate remained a drink that only wealthy people could afford to drink until the eighteenth century. During the period known as the Industrial Revolution, new technologies helped make chocolate less costly to produce. Farmers grow cacao trees in many countries in Africa, Central and South America, but these trees are difficult to grow. They require an exact amount of water, warmth, soil and protection. After about five years, cacao trees start producing large fruits called pods, which grow near the trunk of the tree. The seeds inside these pods are harvested to make chocolate. Growing cacao is very hard work for farmers. Today, chocolate industry officials, activists, and scientists are working with farmers. They are trying to make sure that cacao can be grown in a way that is easy for the farmers and safe for the environment. The market value of the yearly cacao crop around the world is more than five billion dollars. Chocolate is especially popular in Europe and the United States. Each year, Americans eat an average of more than 5 kilograms of chocolate per person. Specialty shops that sell costly chocolate are also very popular. Many offer chocolate lovers the chance to taste chocolate grown in different areas of the world.
Output: What made it possible to produce chocolate inexpensively?
Mega Man Star Force 2, known in Japan as Shooting Star Rockman 2 (2 Ryusei no Rokkuman Tsu), is a video game developed by Capcom for the Nintendo DS handheld game console.
Output: Who worked on Mega Man Star Force 2?
NSD3/WHSC1L1 histone methyltransferase gene aberrations are observed in leukemia and in breast and lung carcinomas, suggesting that NSD3 is implicated in carcinogenesis. In this study we examined in human breast cancer cells the NSD3L isoform which contains the catalytic histone methyltransferase SET-domain. siRNA directed depletion of NSD3L followed by genome-wide microarray analysis identified NSD3L regulated genes which could be functionally linked to cellular signaling pathways such as cell growth, cell cycle, cell motility, transcription, and apoptosis. Notably up-regulated genes are the cell cycle regulators E2F2 and Arl2. In accordance with a function of NSD3L in cell cycle regulation NSD3L depletion resulted in an increase in the number of cells in the S and G2/M cell cycle phases. Moreover, NSD3L depletion increased the invasiveness of MDA-MB-231 breast cancer cells indicating that NSD3L normally restrain cellular metastatic potential. Together the presented data indicates that NSD3L is a candidate tumor suppressor.
Output: What is the characteristic domain of histone methyltransferases?
The Seven Revenges (Italian: Le sette sfide, also known as Ivan the Conqueror) is a 1961 Italian adventure film directed by Primo Zeglio.
Output: Who was the director of The Seven Revenges?
Siah Sufian (Persian: , also Romanized as Siah Sufian) is a village in Belesbeneh Rural District, Kuchesfahan District, Rasht County, Gilan Province, Iran.
Output: In which country is Siah Sufian?
In locations where summers are warm and winters are cool, trees have a distinctive growth pattern. Tree trunks display alternating bands of light-colored, low density summer growth and dark, high density winter growth. Each light-dark band represents one year. By counting tree rings it is possible to find the number of years the tree lived (Figure 1.1). The width of these growth rings varies with the conditions present that year. A summer drought may make the tree grow more slowly than normal and so its light band will be relatively small. These tree-ring variations appear in all trees in a region. The same distinctive pattern can be found in all the trees in an area for the same time period. Scientists have created continuous records of tree rings going back over the past 2,000 years. Wood fragments from old buildings and ancient ruins can be age dated by matching up the pattern of tree rings in the wood fragment in Cross-section showing growth rings. question and the scale created by scientists. The outermost ring indicates when the tree stopped growing; that is, when it died. The tree-ring record is extremely useful for finding the age of ancient structures. Besides tree rings, other processes create distinct yearly layers that can be used for dating. On a glacier, snow falls in winter but in summer dust accumulates. This leads to a snow-dust annual pattern that goes down into the ice (Figure gather allows them to determine how the environment has changed as the glacier has stayed in its position. Analyses of the ice tell how concentrations of atmospheric gases changed, which can yield clues about climate. The longest cores allow scientists to create a record of polar climate stretching back hundreds of thousands of years. Lake sediments, especially in lakes that are located at the end of glaciers, also have an annual pattern. In the summer, the glacier melts rapidly, producing a thick deposit of sediment. These alternate with thin, clay-rich layers deposited in the winter. The resulting layers, called varves, give scientists clues about past climate conditions (Figure 1.3). A warm summer might result in a very thick sediment layer while a cooler summer might yield a thinner layer.
Output: varves form in __________ .
Jamie Wright (born May 13, 1976) is a Canadian former professional ice hockey left winger who played in the National Hockey League (NHL) with the Dallas Stars, Calgary Flames and Philadelphia Flyers.
Output: What team does Jamie Wright belong to?
Like water and carbon, nitrogen is also repeatedly recycled through the biosphere. This process is called the nitrogen cycle. Nitrogen is one of the most common elements in living organisms. It is important for creating both proteins and nucleic acids, like DNA. The air that we breathe is mostly nitrogen gas (N2 ), but, unfortunately, animals and plants cannot use the nitrogen when it is a gas. In fact, plants often die from a lack of nitrogen even through they are surrounded by plenty of nitrogen gas. Nitrogen gas (N2 ) has two nitrogen atoms connected by a very strong triple bond. Most plants and animals cannot use the nitrogen in nitrogen gas because they cannot break that triple bond. In order for plants to make use of nitrogen, it must be transformed into molecules they can use. This can be accomplished several different ways ( Figure 1.1). Lightning: When lightening strikes, nitrogen gas is transformed into nitrate (NO3 ) that plants can use. Nitrogen fixation: Special nitrogen-fixing bacteria can also transform nitrogen gas into useful forms. These bacteria live in the roots of plants in the pea family. They turn the nitrogen gas into ammonium (NH4 + ) (a process called ammonification). In water environments, bacteria in the water can also fix nitrogen gas into ammonium. Ammonium can be used by aquatic plants as a source of nitrogen. Nitrogen also is released to the environment by decaying organisms or decaying wastes. These wastes release nitrogen in the form of ammonium. Ammonium in the soil can be turned into nitrate by a two-step process completed by two different types of bacteria. In the form of nitrate, nitrogen can be used by plants through the process of assimilation. It is then passed along to animals when they eat the plants. Turning nitrate back into nitrogen gas, the process of denitrification, happens through the work of denitrifying bacteria. These bacteria often live in swamps and lakes. They take in the nitrate and release it back to the atmosphere as nitrogen gas. Just like the carbon cycle, human activities impact the nitrogen cycle. These human activities include the burning of fossil fuels, which release nitrogen oxide gasses into the atmosphere. Releasing nitrogen oxide back into the atmosphere leads to problems like acid rain.
Output: the initial step of producing a nitrogen containing compound from nitrogen in the soil is
One of China's most popular folk arts is paper cutting . Archaeological finds trace the tradition back to the 6thcentury; it is supposed that the beginnings of paper cutting were even a few centuries earlier. Paper cuttings are used for religious purposes, for decoration and as patterns . Today, paper cuttings are mainly used as decoration. They _ walls, windows, doors, columns mirrors, lamps and lanterns in homes. They are also used for decoration on presents, and are given as presents themselves. They are of special importance at festivals. At the Spring Festival for example, entrances are decorated with paper cuttings which are supposed to bring good luck. Paper cuttings are not produced by machine, but by hand. There are two kinds of paper cuttings; scissor cuttings and knife cuttings. Scissor cuttings are fashioned with scissors. Several pieces of paper--- up to eight pieces---are fastened together. The motif is then cut with sharp, pointed scissors. Knife cuttings are fashioned by putting several layers of paper on a relatively soft foundation consisting of a mixture of tallow and ashes. Following a pattern, the artist cuts the motif into the paper with a sharp knife which he usually holds vertically . The advantage of knife cuttings is that considerably more paper cuttings can be made in one operation than scissor cuttings. In the countryside, paper cuttings are usually made only by women and girls. This used to be one of the skills that every girl was to master and that were often used to judge brides . Professional paper cutting artists are, on the other hand, almost always men who have guaranteed incomes and work together in workshops.
Output: Which is the best title of this passage?
Treslin/TICRR (TopBP1-interacting, replication stimulating protein/TopBP1-interacting, checkpoint, and replication regulator), the human ortholog of the yeast Sld3 protein, is an essential DNA replication factor that is regulated by cyclin-dependent kinases and the DNA damage checkpoint. We identified MDM two binding protein (MTBP) as a factor that interacts with Treslin/TICRR throughout the cell cycle. We show that MTBP depletion by means of small interfering RNA inhibits DNA replication by preventing assembly of the CMG (Cdc45-MCM-GINS) holohelicase during origin firing. Although MTBP has been implicated in the function of the p53 tumor suppressor, we found MTBP is required for DNA replication irrespective of a cell's p53 status. We propose that MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells.
Output: Which factor interacts with Treslin/TICRR throughout the cell cycle of human cells?