niryuu/sni-each-converted huggingface dataset:
This article needs an improved plot summary. (November 2015) The Cake Eaters is a small-town, ensemble drama that explores the lives of two interconnected families coming to terms with love in the face of loss. Living in rural America, the Kimbrough family are a conflicted bunch: Easy, the patriarch and local butcher, is grieving over the recent loss of his wife, Ceci, while hiding a secret ongoing affair for years; Beagle, his youngest son who was left to care for his ailing mother, works in the local high school cafeteria by day but has a burning passion inside that manifests itself through painting street signs; and the eldest son, Guy, has been away from the family for years while pursuing his rock star dream in the big city until the day he learns of his mother's death and that he has missed the funeral. Upon Guy's return home, relationships between the characters begin to unravel: Beagle's pent up emotions connect with Georgia Kaminski, a terminally ill teenage girl wanting to experience love before it is too late; Easy's long-time affair with Marg, Georgia's eccentric grandmother, is finally exposed to the Kimbrough children; and Guy discovers that in his absence his high school sweetheart, Stephanie, has moved on and started a family of her own. Consequently, The Kimbroughs and Kaminskis manage to establish new beginnings in facing their varied relationships.
Output: What was the name of the patriarch's wife?
Born on 16 November 1920 in Brunoy, near Paris, Jean Boulet was first hired in 1947 by the SNCASE, which would become Sud Aviation and then later the Division Helicopteres of the Societe Nationale Industrielle Aerospatiale.
Output: What is Jean Boulet's place of employment?
Carbon is one of the most common elements found in living organisms. Chains of carbon molecules form the backbones of many organic molecules, such as carbohydrates, proteins, and lipids. Carbon is constantly cycling between living organisms and the atmosphere ( Figure 1.1). The cycling of carbon occurs through the carbon cycle. Living organisms cannot make their own carbon, so how is carbon incorporated into living organisms? In the atmosphere, carbon is in the form of carbon dioxide gas (CO2 ). Recall that plants and other producers capture the carbon dioxide and convert it to glucose (C6 H12 O6 ) through the process of photosynthesis. Then as animals eat plants or other animals, they gain the carbon from those organisms. The chemical equation of photosynthesis is 6CO2 + 6H2 O C6 H12 O6 + 6O2 . How does this carbon in living things end up back in the atmosphere? Remember that we breathe out carbon dioxide. This carbon dioxide is generated through the process of cellular respiration, which has the reverse chemical reaction as photosynthesis. That means when our cells burn food (glucose) for energy, carbon dioxide is released. We, like all animals, exhale this carbon dioxide and return it back to the atmosphere. Also, carbon is released to the atmosphere as an organism dies and decomposes. Cellular respiration and photosynthesis can be described as a cycle, as one uses carbon dioxide (and water) and makes oxygen (and glucose), and the other uses oxygen (and glucose) and makes carbon dioxide (and water). The carbon cycle. The cycling of car- bon dioxide in photosynthesis and cellular respiration are main components of the carbon cycle. Carbon is also returned to the atmosphere by the burning of organic matter (combustion) and fossil fuels and decomposition of organic matter. Millions of years ago, there were so many dead plants and animals that they could not completely decompose before they were buried. They were covered over by soil or sand, tar or ice. These dead plants and animals are organic matter made out of cells full of carbon-containing organic compounds (carbohydrates, lipids, proteins and nucleic acids). What happened to all this carbon? When organic matter is under pressure for millions of years, it forms fossil fuels. Fossil fuels are coal, oil, and natural gas. When humans dig up and use fossil fuels, we have an impact on the carbon cycle ( Figure 1.2). This carbon is not recycled until it is used by humans. The burning of fossil fuels releases more carbon dioxide into the atmosphere than is used by photosynthesis. So, there is more carbon dioxide entering the atmosphere than is coming out of it. Carbon dioxide is known as a greenhouse gas, since it lets in light energy but does not let heat escape, much like the panes of a greenhouse. The increase of greenhouse gasses in the atmosphere is contributing to a global rise in Earths temperature, known as global warming or global climate change.
Output: when organisms die, what process returns their carbon back into the atmosphere?
Karel Halir was born in Hohenelbe, Bohemia (now Vrchlabi, Czech Republic), and studied with Antonin Bennewitz in Prague and with Joseph Joachim in Berlin.
Output: What is the name of the city Karel Halíř was born in?
Mowat-Wilson syndrome (MWS) is a relatively newly described multiple congenital anomaly/mental retardation syndrome. Haploinsufficiency of a gene termed ZFHX1B (also known as SIP1) on chromosome 2 is responsible for this condition, and clinical genetic testing for MWS recently became available. The majority of reports in the literature originate from Northern Europe and Australia. Here we report our clinical experience with 12 patients diagnosed with MWS within a 2-year period of time in the United States, with particular emphasis on clinical characteristics and management strategies. Individuals with this condition have characteristic facial features, including microcephaly, hypertelorism, medially flared and broad eyebrows, prominent columella, pointed chin, and uplifted earlobes, which typically prompt the clinician to consider the diagnosis. Medical issues in our cohort of patients included seizures (75%) with no predeliction for any particular seizure type; agenesis of the corpus callosum (60% of our patients studied); congenital heart defects (75%), particularly involving the pulmonary arteries and/or valves; hypospadias (55% of males); severely impaired or absent speech (100% of individuals over 1 year of age) with relatively spared receptive language; and Hirschsprung disease (50%) or chronic constipation (25%). The incidence of MWS is unknown, but based on the number of patients identified in a short period of time within the US, it is likely greatly under recognized. MWS should be considered in any individual with severely impaired or absent speech, especially in the presence of seizures and anomalies involving the pulmonary arteries (particularly pulmonary artery sling) or pulmonary valves.
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Between 1992 and 1994, Porsche Motorsports Research and Development built and provided a full "Race" version (stripped out 968 Turbo S) for Porsches customer race teams. The 968 Turbo RS was available in two variations; a version using the K27 turbocharger from the Turbo S, which was built to the German ADAC GT specification (ballast added to bring the car up to the 1,350 kg minimum weight limit), and an international spec version which used a KKK L41 turbocharger producing and was reduced to 1,212 kg in weight. Only 4 were ever produced ; 1 Guards Red (WPOZZZ96ZNS820065), 1 Speed Yellow (WPOZZZ96ZPS896061), 1 Black (WPOZZZ96ZPS896062) and 1 White (WPOZZZ96ZPS896063). These are the rarest 968s ever produced.
Output: Which variation of the 968 Turbo RS weighed less?
ABC Nepal is an organisation led by Ms Durga Ghimire, one of the prominent socialites in Nepal working in the field of women rights.
Output: Who led ABC Nepal?
For each vintage, the CIVC rated the villages of the area based on the quality of their grapes and vineyards. The rating was then used to determine the price and the percentage of the price that growers get. The Grand Cru rated vineyards received 100 percent rating which entitled the grower to 100% of the price. Premier Crus were vineyards with 9099% ratings while Deuxieme Crus received 8089% ratings. Under appellation rules, around 4,000 kilograms (8,800 pounds) of grapes can be pressed (wine) to create up to 673 gallons (US) (either 2,550 L or 3,060 L) of juice. The first 541 gallons (either 2,050 L or 2,460 L) are the cuvee and the next 132 gallons (either 500 L or 600 L) are the taille. Prior to 1992, a second taille of 44 gallons (either 167 L or 200 L) was previously allowed. For vintage Champagne, 100% of the grapes must come from that vintage year while non-vintage wine is a blend of vintages. Vintage champagne must spend a minimum of three years of aging. There are no regulations about how long it must spend on its Lees (fermentation), but some of the premier Champagne houses keep their wines on Lees (fermentation) for upwards of five to ten years. Non-vintage Champagne must spend a minimum of 15 months of aging but only a minimum of 12 months on the lees. Most of the Champagne houses keep their wines on the lees through the whole time of aging because it is more expense to bottle the wine then age it and finally shipped.
Output: Which vinyards had the highest ratings?
The Danses gothiques (Gothic Dances) is an 1893 piano composition by Erik Satie, one of the works of his ''Rosicrucian'' or ''mystic'' period.
Output: What musical instrument is Danses gothiques associated with?
Many patients with restless legs syndrome (Willis-Ekbom disease) complain of burning sensations in their feet associated with the desire to move, such that they seek cooler environments. This pilot study aimed to characterise the microvascular skin changes in 12 patients with restless legs syndrome compared with 12 age- and sex-matched controls. Patients with moderate or severe restless legs syndrome and controls underwent detailed thermovascular assessment in a controlled temperature room at three different stages (normothermic phase 23C, hot phase 30C, cold phase 18C). Microvascular activity was recorded during all phases by bilateral great toe laser-Doppler flowmetry and also by whole-body thermography. Patient and control measurements were compared. The study protocol was well tolerated. Parameters extracted from the laser-Doppler flowmetry measurements were used to model a logistic function using binary logistic regression. This demonstrated a statistically significant difference between patients with restless legs syndrome and healthy controls (P<0.001). Visual inspection of the body thermography image sequences showed increased lower limb movement in patients with restless legs syndrome patients compared with controls. Thermography analysis also showed significant differences between foot temperatures in patients with restless legs syndrome compared with controls during the hot phase (P=0.011). Notably, patients with restless legs syndrome had more uniform foot temperatures, whereas controls had a wider variability in surface temperature across the feet. This novel study demonstrates impaired microvascular circulation in patients with restless legs syndrome in comparison to matched controls and a potential mechanism for the sensation of burning feet. The protocol also provides an experimental paradigm to test therapeutic interventions for the future.
Output: Willis-Ekbom disease is also known as?
Hi Fly Malta is a Maltese charter airline based at Malta International Airport and a subsidiary of the Portuguese Hi Fly.
Output: What is the name of the airport associated with Hi Fly Malta?
Chronic myeloid leukemia (CML) was the first human malignant disease to be linked to a single, acquired genetic abnormality. Identification of the Bcr-Abl kinase fusion protein and its pivotal role in the pathogenesis of CML provided new opportunities to develop molecular-targeted therapies. Imatinib mesylate (IM, Gleevec, Novartis Pharmaceuticals, Basel, Switzerland), which specifically inhibits the autophosphorylation of the Abl TK, has improved the treatment of CML. However, resistance is often reported in patients with advanced-stage disease. Several novel TK inhibitors have been developed that override IM resistance mechanisms caused by point mutations within the Abl kinase domain. Inhibitors of Abl TK are divided into two main groups, namely, ATP-competitive and ATP noncompetitive inhibitors. The ATP-competitive inhibitors fall into two subclasses, the Src/Abl inhibitors, and the 2-phenylaminopyrimidine-based compounds. Dasatinib (formerly BMS-354825), AP23464, SKI-606, and PD166326 are classified as Src/Abl inhibitors, while nilotinib (AMN107) and INNO-406 (NS-187) belong to the latter subclass of inhibitors. Of these agents, dasatinib and nilotinib underwent clinical trials earlier than the others and favorable results are now accumulating. Clinical studies of the other compounds, including SKI-606 and INNO-406, have been performed in rapid succession. Because of their strong affinities for the ATP-binding site compared to IM, most ATP-competitive inhibitors may be effective in IM-resistant patients. However, an ATP-competitive inhibitor that can inhibit the phosphorylation of T315I Bcr-Abl has not yet been developed. Instead, ATP noncompetitive inhibitors, such as ON012380, Aurora kinase inhibitor MK0457 (VX-680), and p38 MAP kinase inhibitor BIRB-796, have been developed to address this problem. This review provides an update on the underlying pathophysiologies of disease progression and IM resistance, and discusses the development of new targeted TK inhibitors for managing CML and the importance of future strategies targeting CML stem cells.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Coming off their win over the 49ers the Falcons flew to Cleveland Browns Stadium for an Interconference duel against the Cleveland BrownsAfter a scoreless 1st quarter, the Falcons got things started in the 2nd quarter. Matt Bryant converted a 24-yard field goal. The Browns replied and took the lead with QB Seneca Wallace's 19-yard TD pass to RB Peyton Hillis. The Falcons tried to cut the lead when Bryant made a 30-yard field goal, but was expanded again in the 3rd quarter with kicker Phil Dawson hitting a 19-yard field goal. After that, the Falcons scored when QB Matt Ryan connected with WR Roddy White on a 45-yard TD pass. The game was a defensive drag out the rest of the way. In the 4th quarter DE Kroy Biermann returned an interception 41 yards to the endzone for a touchdown, sealing the Falcons' 4th straight win.
Output: Which player scored the second longest field goal?
Singapore's selection as the host of the 28th Southeast Asian Games of 2015 was announced in 2011 during the 26th Southeast Asian Games, held in Indonesian cities Palembang and Jakarta. Singapore had previously been nominated to host the event in 2007 and 2013, but turned down both opportunities citing costs associated with the construction of the new Singapore Sports Hub.
Output: What happened first: 26th Southeast Asian Games or 28th Southeast Asian Games?
Coming off huge home wins against the 49ers and Steelers, the Seahawks traveled to Minneapolis to take on the Minnesota Vikings. Despite being without both Marshawn Lynch and Jimmy Graham, the Seahawks dominated the Vikings 38-7. Going into the game, the Vikings were previously 8-3 and leading the NFC North, led the NFL in team rushing yards, and Adrian Peterson was the NFL's leading rusher. The Seahawks defense held Peterson to only 18 yards and the Vikings' offense failed to score (their only points coming on a special-teams kickoff return), while Russell Wilson and the Seattle offense racked up 433 yards, five total touchdowns, and no interceptions.
Output: How many teams did the Seahawks win before playing Minnesota?
Fossils are our best form of evidence about Earth history, including the history of life. Along with other geological evidence from rocks and structures, fossils even give us clues about past climates, the motions of plates, and other major geological events. Since the present is the key to the past, what we know about a type of organism that lives today can be applied to past environments. That life on Earth has changed over time is well illustrated by the fossil record. Fossils in relatively young rocks resemble animals and plants that are living today. In general, fossils in older rocks are less similar to modern organisms. We would know very little about the organisms that came before us if there were no fossils. Modern technology has allowed scientists to reconstruct images and learn about the biology of extinct animals like dinosaurs! By knowing something about the type of organism the fossil was, geologists can determine whether the region was terrestrial (on land) or marine (underwater) or even if the water was shallow or deep. The rock may give clues to whether the rate of sedimentation was slow or rapid. The amount of wear and fragmentation of a fossil allows scientists to learn about what happened to the region after the organism died; for example, whether it was exposed to wave action. The presence of marine organisms in a rock indicates that the region where the rock was deposited was once marine. Sometimes fossils of marine organisms are found on tall mountains indicating that rocks that formed on the seabed were uplifted. By knowing something about the climate a type of organism lives in now, geologists can use fossils to decipher the climate at the time the fossil was deposited. For example, coal beds form in tropical environments but ancient coal beds are found in Antarctica. Geologists know that at that time the climate on the Antarctic continent was much warmer. Recall from the chapter Plate Tectonics that Wegener used the presence of coal beds in Antarctica as one of the lines of evidence for continental drift. An index fossil can be used to identify a specific period of time. Organisms that make good index fossils are distinctive, widespread, and lived briefly. Their presence in a rock layer can be used to identify rocks that were deposited at that period of time over a large area. The fossil of a juvenile mammoth found near downtown San Jose California reveals an enormous amount about these majestic creatures: what they looked like, how they lived, and what the environment of the Bay Area was like so long ago.
Output: compared with fossils in younger rocks, fossils in older rocks are
Sotos syndrome is a genetic disorder characterized by a typical facial appearance, macrocephaly, accelerated growth, developmental delay, and a variable range of associated abnormalities. The NSD1 gene was recently found to be responsible for Sotos syndrome, and more than 150 patients with NSD1 alterations have been identified. A significant ethnic difference is found in the prevalence of different types of mutation, with a high percentage of microdeletions identified in Japanese Sotos syndrome patients and with intragenic mutations in most non-Japanese patients. NSD1 aberrations are rather specific for Sotos syndrome, but have also been detected in patients lacking one or more major criteria of the disorder, namely overgrowth, macrocephaly, and advanced bone age. Thus, new diagnostic criteria should be considered. Studies have reported different frequencies of mutations versus non-mutations in Sotos syndrome, thus indicating allelic or locus hetereogeneity. Although some authors have suggested genotype/phenotype correlations, further studies are needed.
Output: Which gene is responsible for the development of Sotos syndrome?
The female reproductive organs include the vagina, uterus, fallopian tubes, and ovaries ( Figure 1.1). The breasts are not shown in this figure. They are not considered reproductive organs, even though they are involved in reproduction. They contain mammary glands that give milk to feed a baby. The milk leaves the breast through the nipple when the baby sucks on it. The vagina is a cylinder-shaped organ found inside of the female body. One end of the vagina opens at the outside of the body. The other end joins with the uterus. During sexual intercourse, sperm may be released into the vagina. If this occurs, the sperm will move through the vagina and into the uterus. During birth, a baby passes from the uterus to the vagina to leave the body. The uterus is a hollow organ with muscular walls. The part that connects the vagina with the uterus is called the cervix. The uterus is where a baby develops until birth. The walls of the uterus grow bigger as the baby grows. The muscular walls of the uterus push the baby out during birth. This drawing shows the organs of the female reproductive system. It shows the organs from the side. Find each organ in the drawing as you read about it in the text. The two ovaries are small, oval organs on either side of the uterus. Each ovary contains thousands of eggs, with about 1-2 million immature eggs present at birth and 40,000 immature eggs present at puberty, as most of the eggs die off. The eggs do not fully develop until a female has gone through puberty. About once a month, on average one egg completes development and is released by the ovary. The ovaries also secrete estrogen, the main female sex hormone. The two fallopian tubes are narrow tubes that open off from the uterus. Each tube reaches for one of the ovaries, but the tubes are not attached to the ovaries. The end of each fallopian tube by the ovary has fingers ( Figure 1.1). They sweep an egg into the fallopian tube. Then the egg passes through the fallopian tube to the uterus. If an egg is to be fertilized, this will occur in the fallopian tube. A fertilized egg then implants into the wall of the uterus, where it begins to develop. An unfertilized egg will flow through the uterus and be excreted from the body.
Output: where does fertilization occur?
Qapaqtaz (Persian: , also Romanized as Qapaqtaz and Qapaqtaz) is a village in Balaband Rural District, in the Central District of Fariman County, Razavi Khorasan Province, Iran.
Output: Which country can you find Qapaqtaz?
Polar Boy is a fictional character from the 30th century of the DC Universe, initially suggested by reader Buddy Lavigne of Northbrook, Illinois in the letters page of Adventure Comics #304, January, 1963.
Output: What is the name of the fictional universe that Polar Boy is from?
Melchior von Meckau (1440--1509) (called the Cardinal of Brixen) was a German Roman Catholic cardinal and bishop.
Output: Which was the position that Melchior von Meckau held?
In week 11 following their bye-week, the Lions hosted the Jacksonville Jaguars. The Jaguars opened the scoring in the first quarter via a 27-yard field goal from Jason Myers. The Lions' first score came in the second quarter on a 55-yard punt return from Andre Roberts, but the extra point try by Matt Prater was partially blocked and failed. The Jaguars responded with a three-yard touchdown pass from Blake Bortles to Allen Robinson, but the conversion attempt by Myers also failed. The Lions then scored on a 27-yard field goal from Matt Prater, which tied the score at 9-9 at halftime. The Lions took the lead in the third quarter via a 39-yard interception return from Rafael Bush. The Jaguars responded with 10 points in the third quarter via a 52-yard field goal from Myers, and a three-yard touchdown pass from Bortles to Marqise Lee, giving them a 19-16 lead. The Lions, trailing for the ninth straight game when entering the fourth quarter, would score the final 10 points of the game. The Lions offense scored its first and only touchdown on a one-yard run from Eric Ebron, and Matt Prater added a 43-yard field goal with 22 seconds left in the game. On the final drive for the Jaguars, Tavon Wilson intercepted a pass from Bortles, sealing the Lions 26-19 victory. The Lions became the first team in NFL history to have its first ten games of a season all decided by seven or fewer points.
Output: Which player scored first in the second quarter?
Possum Paddock is a 1921 Australian film based on a popular play by Kate Howarde.
Output: When was Possum Paddock released?
The following five destination shall never be missed *Blue Lagoon : Blue Lagoon geothermal spa is one of the most visited attractions in Iceland. The warm waters are rich in minerals and bathing in the Blue Lagoon is reputed to help some people suffering from skin diseases. The water temperature in the bathing and swimming area of the Lagoon averages 37degC - 39degC(99F -102F). The Blue Lagoon also operates a research and development facility to help find cures for skin diseases using the mineral-rich water. *Budapest: Budapest holds the title "City of Spas" since the year 1934, as it has more hot and medicinal water springs than any other capital city in the world. There are 118 springs in Budapest, providing over 70 million liters of hot water a day. The temperature of the waters is between 22degC and 40degC. *El Tatio: El Tatio is a geyser field located within the Andes Mountains of northern Chile at 4,320 meters above sea level. With over 80 active geysers, the site is the largest geyser field in the southern hemisphere and the third largest in the world. It is a major tourist attraction in Chile and is among the highest-elevation geyser fields in the world. The temperature of the waters goes between 70degC and 85degC. *Hokkaido: Visitors to the Japanese island of Hokkaido have plenty of options. These range from top resorts with thermal baths like the Spa Resort Hawaiians to small traditional inns that have their own small hot pools with water temperature comfortable to skin. Some bathing spots are outdoors and are not associated with any spa or inn. The classic forest and mountain landscapes of this nature-rich island make it a great choice for those seeking a science setting for their baths.
Output: Which site of the spring has the greatest gap of water temperature?
De Quervain's disease has different clinical features. Different tests have been described in the past, the most popular test being the Eichhoff's test, often wrongly named as the Finkelstein's test. Over the years, a misinterpretation has occurred between these two tests, the latter being confused with the first. To compare the Eichhoff's test with a new test, the wrist hyperflexion and abduction of the thumb test, we set up a prospective study over a period of three years for a cohort of 100 patients (88 women, 12 men) presenting spontaneous pain over the radial side of the styloid of the radius (de Quervain tendinopathy). The purpose of the study was to compare the accuracy of the Eichhoff's test and wrist hyperflexion and abduction of the thumb test to diagnose correctly de Quervain's disease by comparing clinical findings using those tests with the results on ultrasound. The wrist hyperflexion and abduction of the thumb test revealed greater sensitivity (0.99) and an improved specificity (0.29) together with a slightly better positive predictive value (0.95) and an improved negative predictive value (0.67). Moreover, the study showed us that the wrist hyperflexion and abduction of the thumb test is very valuable in diagnosing dynamic instability after successful decompression of the first extensor compartment. Our results support that the wrist hyperflexion and abduction of the thumb test is a more precise tool for the diagnosis of de Quervain's disease than the Eichhoff's test and thus could be adopted to guide clinical diagnosis in the early stages of de Quervain's tendinopathy.
Output: Which disease is diagnosed using the Finkelstein's test?
When we are unfamiliar with something, we may feel nervous and fearful. The help of others is a good way to make us pull through. I write for a big newspaper, and I wanted to write a story about parachute jumping. To make it a realistic as well as exciting story, I decided that I first had to make a jump myself. Unfortunately, I am not good at any sport of any kind, let alone parachute jumping. My friend Mr. Smith was willing to give me a hand. He took me to a ground school. The first day's training included several hours of instruction but not my first drop from an airplane. For this, I had to wait until the following morning. The next morning, after a hurried, anxious breakfast, I was taken to the airfield. There, two heavy parachutes were put on my back. Then I was asked to make my way to a small plane which had just stopped slowly on the runway. Once on the plane, it was soon climbing. I began to feel nervous. As we reached one thousand meters, Harry, my teacher, hooked a line from my parachute to a steel ring inside the plane. The line was to pull my parachute open after I jumped. "Get ready, Henry," Harry said. I moved carefully to the door. I wanted to cry, "No, no, no!" but no word came. "Jump!" Harry called out loudly. "Jump!" To my surprise, kicking like a frog, I did jump. Away from the plane, and down, down I fell. It worked! The air seemed to hold me up. I was very happy. Then I felt a quick pull. My big parachute had opened! It was like the best surprise I'd ever had. I looked down. There were rivers, trees, fields and houses. I heard the soft sound of the air. This was fun!
Output: How did the writer feel after he jumped out of the plane?
The war had three phases. Initially it was a localized feud between supporters of Gebhard and those of the Catholic core of the Cathedral Chapter. With the election of Ernst of Bavaria as a competing archbishop, what had been a local conflict expanded in scale: Ernst's election guaranteed the military, diplomatic, and financial interest of the Wittelsbach family in the Electorate of Cologne's local affairs. After the deaths of Louis VI, Elector Palatine in 1583and William the Silent in 1584, the conflict shifted gears again, as the two evenly matched combatants sought outside assistance to break the stalemate. Finally, the intervention of Alexander Farnese, Duke of Parma, who had at his command the Spanish Army of Flanders, threw the balance of power in favor of the Catholic side. By 1588, Spanish forces had pushed Gebhard from the Electorate. In 1588 he took refuge in Strassburg, and the remaining Protestant strongholds of the Electorate fell to Parma's forces in 1589.
Output: Who died first, Louis VI, Elector Palatine or William the Silent?
Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.
Output: Which is the receptor for substrates of Chaperone Mediated Autophagy?
Riparian Plaza was designed by Harry Seidler (architect) and Robert Bird Group (structural engineer).
Output: By which person Riparian Plaza has been designed?
Trying to avoid a five-game losing streak, the Broncos went home for a Week 12 Interconference Duel against the New York Giants. In the first quarter the Broncos got on the board with kicker Matt Prater making a 26-yard field goal and then a 32-yard field goal in the second quarter. The Broncos kept on top with RB Knowshon Moreno making a 1-yard touchdown run. After that Matt Prater made a 47-yard field goal to end the half. In the third quarter the Giants replied with kicker Lawrence Tynes nailing a 39 then a 52-yard field goal. In the fourth quarter Denver increased their lead with QB Kyle Orton making a 17-yard touchdown pass to WR Brandon Stokley, and Prater making a 24-yard field goal.
Output: What was the last score type of the first half?
Electromagnetic radiation is energy that travels in waves across space as well as through matter. Most of the electromagnetic radiation on Earth comes from the sun. Like other waves, electromagnetic waves are characterized by certain wavelengths and wave frequencies. Wavelength is the distance between two corresponding points on adjacent waves. Wave frequency is the number of waves that pass a fixed point in a given amount of time. Electromagnetic waves with shorter wavelengths have higher frequencies and more energy. Visible light and infrared light are just a small part of the full range of electromagnetic radiation, which is called the electromagnetic spectrum. You can see the waves of the electromagnetic spectrum in the Figure 1.1. At the top of the diagram, the wavelengths of the waves are given. Also included are objects that are about the same size as the corresponding wavelengths. The frequencies and energy levels of the waves are shown at the bottom of the diagram. Some sources of the waves are also given. On the left side of the electromagnetic spectrum diagram are radio waves and microwaves. Radio waves have the longest wavelengths and lowest frequencies of all electromagnetic waves. They also have the least amount of energy. On the right side of the diagram are X rays and gamma rays. They have the shortest wavelengths and highest frequencies of all electromagnetic waves. They also have the most energy. Between these two extremes are waves that are commonly called light. Light includes infrared light, visible light, and ultraviolet light. The wavelengths, frequencies, and energy levels of light fall in between those of radio waves on the left and X rays and gamma rays on the right. Q: Which type of light has the longest wavelengths? A: Infrared light has the longest wavelengths. Q: What sources of infrared light are shown in the diagram? A: The sources in the diagram are people and light bulbs, but all living things and most other objects give off infrared light.
Output: electromagnetic waves with the greatest amount of energy are
Two forms of neurofibromatosis, type 1 (NF1) and type 2 (NF2) are connected with genes localized on chromosomes 17 and 22, respectively. The genes that are inactivated in neurofibromatosis code for the proteins neurofibromine and merline, respectively. Since inactivation leads to neoplasia, they are called tumour suppressor genes. Neurofibromine shows resemblances to proteins that serve to inactivate oncogenes. Merline has a relationship with proteins that connect the cytoskeleton and the cell membrane. The precise function of the proteins is still unknown. The NF1 gene is characterized by extraordinarily high sensitivity to mutation; half the NF1 patients have not inherited the disease. In the familial form of neurofibromatosis, a mutated gene is inherited and the normal allele in the tumour is inactivated, making tumour growth possible. In the sporadic form of neurofibromatosis, both normal alleles are inactivated locally in the tissue so that a tumour develops in that place.
Output: Which is the gene mutated in type 1 neurofibromatosis?
The 1965 Skyways Coach-Air Avro 748 crash occurred on 10 July 1965 when Avro 748-101 Series 1 G-ARMV, flown during a scheduled international passenger flight from Beauvais Airport, Oise, France, crashed on landing at its intended destination of Lympne Airport, Kent, United Kingdom.
Output: What was the date of 1965 Skyways Coach-Air Avro 748 crash?
Radioactive decay is the process in which the nuclei of radioactive atoms emit charged particles and energy, which are called by the general term radiation. Radioactive atoms have unstable nuclei, and when the nuclei emit radiation, they become more stable. Radioactive decay is a nuclearrather than chemicalreaction because it involves only the nuclei of atoms. In a nuclear reaction, one element may change into another. Click image to the left or use the URL below. URL: There are several types of radioactive decay, including alpha, beta, and gamma decay. In all three types, nuclei emit radiation, but the nature of the radiation differs. The Table 1.1 shows the radiation emitted in each type of decay. Type Alpha decay Beta decay Gamma decay Radiation Emitted alpha particle (2 protons and 2 neutrons) + energy beta particle (1 electron or 1 positron) + energy energy (gamma ray) Both alpha and beta decay change the number of protons in an atoms nucleus, thereby changing the atom to a different element. In alpha decay, the nucleus loses two protons. In beta decay, the nucleus either loses a proton or gains a proton. In gamma decay, no change in proton number occurs, so the atom does not become a different element. Q: If the radioactive element polonium (Po) undergoes alpha decay, what element does it become? A: From the periodic table, the atomic number of polonium is 84, so it has 84 protons. If it loses two protons through alpha decay, it will have 82 protons. Atoms with 82 protons are the element lead (Pb). The charged particles and energy emitted during radioactive decay can harm living things, but the three types of radioactive decay arent equally dangerous. Thats because they differ in how far they can travel and what they can penetrate. You can see this in the Figure 1.1.
Output: the type of radioactive decay that occurs when a nucleus emits an electron is
Neurofibromatosis type 1 (NF1) is characterized primarily by tumor formation in the nervous system, but patients report other neurological complications including pain and itch. Individuals with NF1 harbor 1 mutated NF1 allele causing heterozygous expression in all of their cells. In mice, Nf1 heterozygosity leads to hyperexcitability of sensory neurons and hyperproliferation of mast cells, both of which could lead to increased hypersensitivity and scratching in response to noxious and pruritic stimuli. To determine whether Nf1 heterozygosity may increase pain and itch behaviors independent of secondary effects of tumor formation, we used mice with a targeted, heterozygous Nf1 gene deletion (Nf1) that lack tumors. Nf1 mice exhibited normal baseline responses to thermal and mechanical stimuli. Moreover, similar to wild-type littermates, Nf1 mice developed inflammation-induced heatand mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia. However, Nf1mice exhibited an attenuated first phase of formalin-induced spontaneous behavior and expedited resolution of formalin-induced heat hypersensitivity. These results are not consistent with the hypothesis that Nf1 heterozygosity alone is sufficient to increase pain and itch sensation in mice, and they suggest that additional mechanisms may underlie reports of increased pain and itch in NF1 patients. This study assessed whether Nf1 heterozygosity in mice increased hypersensitivity and scratching following noxious and pruritic stimuli. Using Nf1 mice lacking tumors, this study finds no increases in pain or itch behavior, suggesting that there is no predisposition for either clinical symptom solely due to Nf1 heterozygosity.
Output: Which is the gene mutated in type 1 neurofibromatosis?
The Kungsbacka Fjord (Swedish: Kungsbackafjorden) is a fjord and a nature reserve in Halland County, western Sweden.
Output: Which country can you find Kungsbacka Fjord?
We report a novel mutation in the XK gene (XK) in a Japanese patient with McLeod syndrome. A 50-year-old man showed progressive muscular atrophy, choreic movement, elevated level of serum creatinine kinase, and acanthocytosis. The expression level of all the Kell antigens in erythrocyte was decreased and molecular analysis revealed a single-base (T) deletion at the nucleotide position 1095 in XK. This deletion caused a frameshift in translation, leading to a premature stop codon at the amino acid position 408. We conclude this single-base deletion causes defective Kx protein, which is responsible for the McLeod phenotype in this patient.
Output: Mutation of which gene is associated with McLeod syndrome?
The TauTona Mine or Western Deep No.3 Shaft, is a gold mine in South Africa.
Output: What product does TauTona Mine produce?
Witches' Flight (Spanish: Vuelo de Brujas; also known as Witches in Flight or Witches in the Air), is an oil on canvas painting completed in 1798 by the Spanish painter Francisco Goya.
Output: What is the surface of Witches' Flight made of?
Theories for restless legs syndrome (RLS) pathogenesis include iron deficiency, dopamine dysregulation and peripheral neuropathy. Increased prevalence of small intestinal bacterial overgrowth (SIBO) in controlled studies in RLS and case reports of post-infectious RLS suggest potential roles for inflammation and immunological alterations. A literature search for all conditions associated with RLS was performed. These included secondary RLS disorders and factors that may exacerbate RLS. All of these conditions were reviewed with respect to potential pathogenesis including reports of iron deficiency, neuropathy, SIBO, inflammation and immune changes. A condition was defined as highly-associated if there was a prevalence study that utilized an appropriate control group. Small case reports were recorded but not included as definite RLS-associated conditions. Fifty four diseases, syndromes and conditions have been reported to cause and/or exacerbate RLS. Of these, 38 have been reported to have a higher prevalence than age-matched controls, 9 have adequate sized reports and have general acceptance as RLS-associated conditions and 7 have been reported in case report form. Overall, 42 of the 47 RLS-associated conditions (89%) have also been associated with inflammatory and/or immune changes. In addition, 43% have been associated with peripheral iron deficiency, 40% with peripheral neuropathy and 32% with SIBO. Most of the remaining conditions have yet to be studied for these factors. The fact that 95% of the 38 highly-associated RLS conditions are also associated with inflammatory/immune changes suggests the possibility that RLS may be mediated or affected through these mechanisms. Inflammation can be responsible for iron deficiency and hypothetically could cause central nervous system iron deficiency-induced RLS. Alternatively, an immune reaction to gastrointestinal bacteria or other antigens may hypothetically cause RLS by a direct immunological attack on the central or peripheral nervous system.
Output: Which deficiency is the cause of restless leg syndrome?
Why should mankind explore space? Why should money, time and effort be spent exploring and researching something with so few obvious benefits? Why should resources be spent on space rather than on conditions and people on Earth? These are questions that, understandably, are very often asked. Perhaps the best answer lies in our genetic makeup as human beings. What drove our ancestors to move from the trees into the plains, and on into all possible areas and environments? The wider the spread of a species, the better its chance of survival. Perhaps the best reason for exploring space is this genetic tendency to expand wherever possible. Nearly every successful civilization has explored, because by doing so, any dangers in surrounding areas can be identified and prepared for. Without knowledge, we may be completely destroyed by the danger. With knowledge, we can lessen its effects. Exploration also allows minerals and other potential resources to be found. Even if we have no immediate need of them, they will perhaps be useful later. Resources may be more than physical possessions . Knowledge or techniques have been gained through exploration. The techniques may have medical applications which can improve the length or quality of our lives. We have already benefited from other spin-offs including improvements in earthquake prediction, in satellites for weather forecasting and in communications systems. Even non-stick pans and mirrored sunglasses are by-products of technological developments in the space industry! While many resources are spent on what seems a small return, the exploration of space allows creative, brave and intelligent members of our species to focus on what may serve to save us. While space may hold many wonders and explanations of how the universe was formed or how it works, it also holds dangers. The danger exists, but knowledge can help human being to survive. Without the ability to reach out across space, the chance to save ourselves might not exist. While Earth is the only planet known to support life, surely the adaptive ability of humans would allow us to live on other planets. It is true that the lifestyle would be different, but human life and cultures have adapted in the past and surely could in the future.
Output: What makes it possible for humans to live on other planets?
To investigate the use of tanezumab, a humanized monoclonal antibody that inhibits nerve growth factor, for the treatment of moderate to severe osteoarthritis in Japanese patients. Patients received tanezumab 10, 25, 50, 100, 200g/kg, or placebo and were followed for 92 or 120 days. Endpoints included the incidence of adverse events (AEs) and the change from baseline to week 8 in pain intensity and the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) subscales. Patients (n=83) were 69% female, age 44-73 years, with a Kellgren-Lawrence X-ray grade of 2-4. At week 8, compared with placebo, tanezumab 25, 100, and 200g/kg improved index knee pain during walking (-18.5,-14.3, and-27.6, respectively), index knee pain in the past 24h (-19.1,-14.6, and-24.2, respectively), current index knee pain (-16.5,-10.9, and-22.8, respectively), and the WOMAC pain (-11.5,-9.6, and-18.8, respectively), physical function (-8.7,-9.5, and-17.6, respectively), and stiffness (-20.4,-11.2, and-10.2, respectively) subscales. Overall, seven patients reported AEs of abnormal peripheral sensation: allodynia (two in the tanezumab 200g/kg group); paresthesia (two in the tanezumab 200g/kg group), dysesthesia (one in the tanezumab 200g/kg group); thermohypoesthesia (one in the tanezumab 100g/kg group), and decreased vibratory sense (one in the placebo group). All of these AEs were mild to moderate in severity and transient in nature. Tanezumab was safe and generally well tolerated and may improve pain symptoms in Japanese patients with moderate to severe osteoarthritis of the knee. CLINICALTRIALS.GOV IDENTIFIER: NCT00669409.
Output: What is the target of tanezumab?
The National Library of Wales hold the only known copy of Yny lhyvyr hwnn.
Output: What is the name of the place where Yny lhyvyr hwnn can be found?
Ivan Grafenauer (7 March 1880 - 29 December 1964) was a Slovenian literary historian and ethnologist of Carinthian Slovene origin.
Output: What language did Ivan Grafenauer speak?
Founded in 2002, Unexploded was asked to perform at several festivals in 2004, but settled for releases on 2 compilations; one in Japan on Stargate Recordings Antenna Volume One in company with amongst others Bill Laswell.
Output: When was Unexploded created?
PSR B1257+12 was discovered by the Polish astronomer Aleksander Wolszczan on February 9, 1990 using the Arecibo radio telescope.
Output: What is the full date of discovery for PSR B1257+12?