niryuu/sni-each-converted huggingface dataset:
Stem cells, one of the progenitors of cancer, exist predominately in a quiescent state. Thus, understanding the mechanisms of DNA repair and mutagenesis in such arrested cells may help unravel the complex process of tumorigenesis. Two major nucleotide excision repair (NER) pathways are known to remove bulky physical or chemical lesions from DNA. Transcription-coupled repair (TCR) acts solely on the transcribed strand of expressed genes, while global genomic repair (GGR) is responsible for the ubiquitous repair of the genome. Indirectly, it has been shown that while TCR functions in quiescent cells GGR does not. To explicitly elucidate this phenomenon, we adapted a quantitative PCR (QPCR) assay to study UV-damage repair via TCR and GGR in quiescent and proliferating cells. We present evidence that repair of untranscribed silent regions of the genome and repair of the non-transcribed strand of active genes proceeds by two discrete mechanisms in quiescent cells; rather than by GGR, which was believed to encompass both. Thus, our findings suggest the existence of an alternate NER pathway in quiescent cells. The proposed subcategories of NER are as follows: (i) TCR, responsible for maintenance of transcribed strands; (ii) GGR, responsible for ubiquitous genome repair; and (iii) non-transcribed strand repair (NTSR), predominantly responsible for the repair of the NTS in arrested cells. In quiescent cells, it is evident that TCR and NTSR function and GGR are arrested. As a consequence, mutation accumulation at temporally silent genes and incomplete or imperfect repair of transcribed genes, in quiescent stem cells, may provide a source of cancer causing mutations.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
Upon hearing this, Murong Wei's brothers Murong Hong and Murong Chong also rose in rebellion near Chang'an.
Output: What is Murong Wei's brothers name?
Most sedimentary rocks form from sediments. Sediments are small pieces of other rocks, like pebbles, sand, silt, and clay. Sedimentary rocks may include fossils. Fossils are materials left behind by once-living organisms. Fossils can be pieces of the organism, like bones. They can also be traces of the organism, like footprints. Most often, sediments settle out of water (Figure 4.13). For example, rivers carry lots of sediment. Where the water slows, it dumps these sediments along its banks, into lakes and the ocean. When sediments settle out of water, they form horizontal layers. A layer of sediment is deposited. Then the next layer is deposited on top of that layer. So each layer in a sedimentary rock is younger than the layer under it. It is older than the layer over it. Sediments are deposited in many different types of environments. Beaches and deserts collect large deposits of sand. Sediments also continuously wind up at the bottom of the ocean and in lakes, ponds, rivers, marshes, and swamps. Avalanches produce large piles of sediment. The environment where the sediments are deposited determines the type of sedimentary rock that can form. Sedimentary rocks form in two ways. Particles may be cemented together. Chemicals may precipitate. Over time, deposited sediments may harden into rock. First, the sediments are compacted. That is, they are squeezed together by the weight of sediments on top of them. Next, the sediments are cemented together. Minerals fill in the spaces between the loose sediment particles. These cementing minerals come from the water that moves through the sediments. These types of sedimentary rocks are called clastic rocks. Clastic rocks are rock fragments that are compacted and cemented together. Clastic sedimentary rocks are grouped by the size of the sediment they contain. Conglomerate and breccia are made of individual stones that have been cemented together. In conglomerate, the stones are rounded. In breccia, the stones are angular. Sandstone is made of sand-sized particles. Siltstone is made of smaller particles. Silt is smaller than sand but larger than clay. Shale has the smallest grain size. Shale is made mostly of clay-sized particles and hardened mud. Chemical sedimentary rocks form when crystals precipitate out from a liquid. The mineral halite, also called rock salt, forms this way. You can make halite! Leave a shallow dish of salt water out in the Sun. As the water evaporates, salt crystals form in the dish. There are other chemical sedimentary rocks, like gypsum. Table 4.1 shows some common types of sedimentary rocks and the types of sediments that make them up. Picture Rock Name Conglomerate Type of Sedimentary Rock Clastic Breccia Clastic Sandstone Clastic Siltstone Clastic Limestone Bioclastic Coal Organic Picture Rock Name Rock Salt Type of Sedimentary Rock Chemical precipitate
Output: What are solid particles that have been deposited on the Earths surface called?
When the dog named Judy spotted the first sheep in her life, she did what comes naturally. The four-year-old dog set off racing after the sheep across several fields and, being a city animal, lost both her sheep and her sense of direction. Then she ran along the edge of cliff( ) and fell 100 feet, bouncing off a rock into the sea. Her owner Mike Holden panicked and celled the coastguard of Cornwall, who turned up in seconds . Six volunteers slid down the cliff with the help of a rope but gave up all hope of finding her alive after a 90-minute search. Three days later, a hurricane hit the coast near Cornwall. Mr. Holden returned home from his holiday upset and convinced his pet was dead. He comforted himself with the thought she had died in the most beautiful part of the country. For the next two weeks, the Holdens were heartbroken . Then, one day, the phone rang and Steve Tregear, the coastguard of Cornwall, asked Holder if he would like his dog bark. A birdwatcher, armed with a telescope, found the pet sitting desperately on a rock. While he sounded the alarm, a student from Leeds climbed down the cliff to collect Judy. The dog had initially been knocked unconscious but had survived by drinking water from a fresh scream at the base of the cliff. She may have fed on the body of a sheep which had also fallen over the edge. "The dog was very thin and hungry," Steve Tregear said , "It was a very dog. She survived because of a plentiful supply of fresh water," he added. It was ,as Mr. Holden admitted, "a minor miracle ".
Output: Who spotted Judy after the accident?
In the same year, Livilla married her cousin Drusus Julius Caesar (Drusus the Younger), the son of Tiberius.
Output: What is Livilla's spouse's name?
Birdcage Inn (Hangul: ; RR: Paran daemun; lit. ''Blue Gate'') is South Korean director Kim Ki-duk's third film, released in 1998.
Output: The main director of Birdcage Inn was who?
One Shell Square is a 51-story, 697-foot (212 m) skyscraper designed in the International style by Skidmore, Owings and Merrill, located at 701 Poydras Street in the Central Business District of New Orleans, Louisiana.
Output: The designer for One Shell Square was?
In previous concepts, you learned about B and T cells, special types of white blood cells that help your body to fight off a specific pathogen. They are necessary when the body is fighting off an infection. But what happens to them after the pathogen has been destroyed? Most B and T cells die after an infection has been brought under control. But some of them survive for many years. They may even survive for a persons lifetime. These long-lasting B and T cells are called memory cells. They allow the immune system to remember the pathogen after the infection is over. If the pathogen invades the body again, the memory cells will start dividing in order to fight the pathogen or disease. These dividing cells will quickly produce a new army of B or T cells to fight the pathogen. They will begin a faster, stronger attack than the first time the pathogen invaded the body. As a result, the immune system will be able to destroy the pathogen before it can cause an infection. Being able to attack the pathogen in this way is called immunity. Immunity can also be caused by vaccination. Vaccination is the process of exposing a person to a pathogen on purpose in order to develop immunity. In vaccination, a modified pathogen is usually injected under the skin by a shot. Only part of the pathogen is injected, or a weak or dead pathogen is used. It sounds dangerous, but the shot prepares your body for fighting the pathogen without causing the actual illness. Vaccination triggers an immune response against the injected antigen. The body prepares "memory" cells for use at a later time, in case the antigen is ever encountered again. Essentially, a vaccine imitates an infection, triggering an immune response, without making a person sick. In many countries, children receive their first vaccination at birth with the Hepatitis B shot, which protects infants from Hepatitis B, a serious liver disease. Before vaccines, many children died from diseases that vaccines now prevent, such as whooping cough, measles, and polio. Those same germs exist today, but because babies are now protected by vaccines, we do not see these diseases nearly as often. Diseases you have probably been vaccinated against include measles, mumps, and chicken pox. How does a vaccine work? See How a Vaccine Works at and The History of Vaccines at . Click image to the left or use the URL below. URL:
Output: what is the first vaccination for many children?
Prince Alfons of Bavaria (German: Alfons Maria Franz von Assisi Klemens Max Emanuel Prinz von Bayern; 24 January 1862 -- 8 January 1933) was a member of the Bavarian Royal House of Wittelsbach and a General of Cavalry.
Output: What family lineage was Prince Alfons of Bavaria part of?
A wedge is simple machine that consists of two inclined planes, giving it a thin end and thick end, as you can see in the Figure 1.1. A wedge is used to cut or split apart objects. Force is applied to the thick end of the wedge, and the wedge, in turn, applies force to the object along both of its sloping sides. This force causes the object to split apart. A knife is another example of a wedge. In the Figure 1.2, a knife is being used to chop tough pecans. The job is easy to do with the knife because of the wedge shape of the blade. The very thin edge of the blade easily enters and cuts through the pecans. The mechanical advantage of a simple machine is the factor by which it multiplies the force applied to the machine. It is the ratio of the output force to the input force. A wedge applies more force to the object (output force) than the user applies to the wedge (input force), so the mechanical advantage of a wedge is greater than 1. A longer, thinner wedge has a greater mechanical advantage than a shorter, wider wedge. With all wedges, the trade-off is that the output force is applied over a shorter distance, so force may need to be applied to the wedge repeatedly to push it through the object. Q: Which wedge in the Figure 1.3 do you think would do the same amount of work with less input force? A: The wedge on the left has a greater mechanical advantage, so it would do the same amount of work with less input force.
Output: a wedge
The Toi invasion was the invasion of northern Kyushu by Jurchen pirates in 1019. At the time, Toi meant "barbarian" in the Korean language. The Toi pirates sailed with about 50 ships from direction of Goryeo, then assaulted Tsushima and Iki, starting 27 March 1019. After the Iki Island garrison comprising 147 soldiers was wiped out, the pirates has proceed to Hakata Bay. For a week, using Noko Island in the Hakata Bay as a base, they sacked villages and kidnapped over 1,000 Japanese, mostly women and young girls, for use as slaves. The Dazaifu, the administrative center of Kyushu, then raised an army and successfully drove the pirates away. During the second failed raid to Matsuura 13 April 1019, three enemies were captured by the Japanese army. They were identified as Koreans. They said that they had guarded the borderland but had been captured by the Toi. However, this was unlikely, and the Japanese officers suspected them because there had been Korean pirates attacking Japan coasts during the Silla period. A few months later, the Goryeo delegate Jeong Jaryang reported that Goryeo forces attacked the pirates off Wonsan and rescued about 260 Japanese. The Korean government then repatriated them to Japan where they were thanked by the Dazaifu and given rewards. There remain detailed reports by two captive women, Kura no Iwame and Tajihi no Akomi. These Jurchen pirates lived in what is today Hamgyongdo, North Korea.
Output: Who took 1000 Japanese for use as slaves?
To evaluate the role of apoptosis in the pathogenesis of brain lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary microangiopathy leading to cognitive decline and dementia, caused by mutations in the NOTCH3 gene. Detection of apoptotic nuclei in temporal lobe, brain stem, medulla oblongata, hippocampus and basal ganglia from one young CADASIL patient was performed by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL). Our results showed a great involvement of glial cells in apoptotic cell death in the majority of the brain regions examined; neuronal apoptosis was significantly present only in the brain stem region. We hypothesized that in the early stages of the disease neuronal involvement of apoptosis is limited to the cells of the brain stem, sparing the cortical area which is involved in neuronal apoptosis and cognitive decline later.
Output: Which gene is involved in CADASIL?
On 1 January 2013, Saint-Germain-sur-l'Arbresle and Nuelles merged becoming one commune called Saint-Germain-Nuelles.
Output: What was replaced Saint-Germain-sur-l'Arbresle?
At the planets center lies a dense metallic core. Scientists know that the core is metal because: 1. The density of Earths surface layers is much less than the overall density of the planet, as calculated from the planets rotation. If the surface layers are less dense than average, then the interior must be denser than average. Calculations indicate that the core is about 85% iron metal with nickel metal making up much of the remaining 15%. 2. Metallic meteorites are thought to be representative of the core. The 85% iron/15% nickel calculation above is also seen in metallic meteorites (Figure 1.1). If Earths core were not metal, the planet would not have a magnetic field. Metals such as iron are magnetic, but rock, which makes up the mantle and crust, is not. Scientists know that the outer core is liquid and the inner core is solid because: 1. S-waves do not go through the outer core. 2. The strong magnetic field is caused by convection in the liquid outer core. Convection currents in the outer core are due to heat from the even hotter inner core. The heat that keeps the outer core from solidifying is produced by the breakdown of radioactive elements in the inner core. Click image to the left or use the URL below. URL:
Output: scientists know which layer of the core is liquid and which is solid because
The loss of chromosome 1p and chromosome 3 is associated with metastatic disease and decreased survival of uveal melanoma (UM) patients. The p53 homologues, p73 and p63, are located on chromosomes 1p and 3q, respectively. Both are able to activate p53 target genes, resulting in growth arrest, apoptosis and differentiation. N-terminally truncated isoforms of these genes may act as dominant negative inhibitors of wild-type p53 and transactivating activity. Although, p53 is frequently involved in several malignancies it does not play a major role in UM. Altered expression has been reported for both p63 and p73 in various malignancies. In this study, fluorescent in-situ hybridization was performed to identify gains or losses of p63 and p73 loci in UM. The expression of the different p63 and p73 isoforms was evaluated by reverse transcriptase PCR followed by Southern blot analysis. Furthermore, the expression pattern of the various DeltaTAp73 transcripts was analysed in seven primary UMs and 11 UM-derived cell lines using isoform-specific real-time PCR. Our results indicated that the isoform p73Deltaex2/3 was abundantly expressed and a relative loss of the p73 locus was associated with the upregulation of p73Deltaex2 and TAp73 transcripts. N-terminal transactivation forms of both p73 and p63 were observed in primary and metastasis-derived cell lines, as well as in primary melanomas, but in only one of the cell lines a DeltaNp63 mRNA transcript was observed. Our data suggest a potential function of p73 deletion transcripts in UM progression.
Output: How many TAp73 isoforms have been identified in humans?
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent adult muscular dystrophies. The common clinical signs usually appear during the second decade of life but when the first molecular dysregulations occur is still unknown. Our aim was to determine whether molecular dysregulations can be identified during FSHD fetal muscle development. We compared muscle biopsies derived from FSHD1 fetuses and the cells derived from some of these biopsies with biopsies and cells derived from control fetuses. We mainly focus on DUX4 isoform expression because the expression of DUX4 has been confirmed in both FSHD cells and biopsies by several laboratories. We measured DUX4 isoform expression by using qRT-PCR in fetal FSHD1 myotubes treated or not with an shRNA directed against DUX4 mRNA. We also analyzed DUX4 downstream target gene expression in myotubes and fetal or adult FSHD1 and control quadriceps biopsies. We show that both DUX4-FL isoforms are already expressed in FSHD1 myotubes. Interestingly, DUX4-FL expression level is much lower in trapezius than in quadriceps myotubes, which is confirmed by the level of expression of DUX4 downstream genes. We observed that TRIM43 and MBD3L2 are already overexpressed in FSHD1 fetal quadriceps biopsies, at similar levels to those observed in adult FSHD1 quadriceps biopsies. These results indicate that molecular markers of the disease are already expressed during fetal life, thus opening a new field of investigation for mechanisms leading to FSHD.
Output: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
Monserrate (after Catalan homonym mountain Montserrat) is a mountain that dominates the city center of Bogota, the capital city of Colombia.
Output: Who is the Monserrate named after?
Peroxiredoxin-2 (PRDX-2) is an antioxidant and chaperone-like protein critical for cell function. This study examined whether the levels of lymphocyte PRDX-2 are altered over 1 month following ultra-endurance exercise. Nine middle-aged men undertook a single-stage, multi-day 233 km (145 mile) ultra-endurance running race. Blood was collected immediately before (Pre), upon completion/retirement (Post), and following the race at Day 1, Day 7 and Day 28. Lymphocyte lysates were examined for PRDX-2 by reducing and non-reducing SDS-PAGE with western blotting. In a sub-group of men who completed the race (n = 4), PRDX-2 oligomeric state (indicative of redox status) was investigated. Ultra-endurance exercise caused significant changes in lymphocyte PRDX-2 (F(4,32) 3.409, p = 0.020, (2) = 0.299): 7 days after the race, PRDX-2 levels in lymphocytes had fallen to 30% of pre-race values (p = 0.013) and returned to near-normal levels at Day 28. Non-reducing gels demonstrated that dimeric PRDX-2 (intracellular reduced PRDX-2 monomers) was increased in three of four race completers immediately post-race, indicative of an 'antioxidant response'. Moreover, monomeric PRDX-2 was also increased immediately post-race in two of four race-completing subjects, indicative of oxidative damage, which was not detectable by Day 7. Lymphocyte PRDX-2 was decreased below normal levels 7 days after ultra-endurance exercise. Excessive accumulation of reactive oxygen species induced by ultra-endurance exercise may underlie depletion of lymphocyte PRDX-2 by triggering its turnover after oxidation. Low levels of lymphocyte PRDX-2 could influence cell function and might, in part, explain reports of dysregulated immunity following ultra-endurance exercise.
Output: What type of enzyme is peroxiredoxin 2 (PRDX2)?
1. In order to investigate the biological function of the human CLN3 gene that is defective in Batten disease, we created a yeast strain by PCR-targeted disruption of the yeast gene (YHC3), which is a homologue of the human CLN3 gene. 2. The phenotypic characterization revealed that the yhc3 delta mutants are more sensitive to combined heat and alkaline stress than the wild-type strains as determined by inhibition of cell proliferation. 3. This suggests that the yhc3 delta mutant is a good model to investigate the biological function of human CLN3 gene in mammalian cells and to understand the pathophysiology of juvenile Batten disease.
Output: What is the effect of a defective CLN3 gene?
Our clothes are a powerful tool that can make us feel better about ourselves. One way in which this works is by wearing different color1s of clothes. Normally when we are sad, we will wear dark color1ed clothes. Oppositely, when we are happy, we often choose to wear brightly color1ed clothes. The reason for this is that our choice of color1 mirrors is how we are feeling. Those who don't believe in the idea are often heard saying, "if only this truly worked". Well in reply to those people, there has been a lot of research into what happens to someone's feelings when they are asked to wear just one color1 of clothes. It has been proven that if we wear particular color1s of clothes they can change our feelings. Suppose we are feeling sad, if we wear black we may begin to feel worse. However, if we wear green, red or yellow, we may begin to feel better. Each color1 is said to have its own healing power. So remember, if you are not feeling your best, you can always try out some different color1ed clothes. If one color1 has no effect on your feelings, maybe another will.
Output: What's the author's attitude toward "wearing particular color1s of clothes can change our feelings"?
In June 1994, Ferrellgas issued partnership units of Ferrellgas Partners, L.P. on the New York Stock Exchange (NYSE) under the ticker symbol FGP.
Output: What stock exchange is most closely associated with Ferrellgas?
Bram Stoker's Dracula's Curse (also known simply as Dracula's Curse) is a 2006 horror film by The Asylum, written and directed by Leigh Scott.
Output: What studio produced Bram Stoker's Dracula's Curse?
The Vikings began their 2010 pre-season with a trip to Edward Jones Dome to take on the league's worst team from 2009, the St. Louis Rams. The Rams roster featured rookie quarterback Sam Bradford, signed as the #1 overall pick in the 2010 NFL Draft. Meanwhile, the Vikings were without six members of their regular starting offense, including QB Brett Favre and RB Adrian Peterson. The Rams got the first touchdown of the game with 1:29 remaining in the first quarter, when Danny Amendola returned a Chris Kluwe punt for 93 yards. The Vikings responded with two TDs in the second quarter; first, backup QB Sage Rosenfels passed for two yards to wide receiver Logan Payne, before throwing a 65-yard TD pass to tight end Garrett Mills. Rosenfels got his third passing TD in the third quarter, with a 71-yard pass to WR Marko Mitchell. The victory was completed with 6:49 left in the game as fellow rookies - QB Joe Webb and TE Mickey Shuler - combined for a two-yard pass.
Output: Who was the Vikings quarterback for the game?
The Stanrock Mine is an historical uranium mine located approximately 11.5 km northeast of Elliot Lake, Ontario, owned by Denison Mines.
Output: What is the product made by Stanrock Mine?
Escort in Love (Italian: Nessuno mi puo giudicare) is a 2011 Italian comedy film directed by Massimiliano Bruno.
Output: The film Escort in Love was directed by whom?
OUR KIDS ARE AMAZING-especially compared with everybody else's (who seem to cry all the time). How do you show your love for your kids this holiday season? With toys that are smooth and colorful, interactive and exciting. And with ones that have educational value-because you are the boss. 1. FLAX ART HOSPITAL PUZZLE AND PLAY SET Here is a toy that doesn't need power-and the bike have to put it together themselves. This 50 piece puzzle set is made of soft edged hardwood and makes a complete hospital, with an X ray room. It also includes eight patients, a car and a driver. $135; flaxart.com. 2. TINY LOVE ACTIVITY BALL Sure, it's cool, but this colorful baby toy also develops problem solving and motor skills. It has a head and legs, a magnetic hand and a tail. Suitable for little ones from 6 to 36 months. $19.95; tinylove.com. 3. ROBOSAPIEN This small, remote control robot is really powerful. It performs 67 preprogrammed functions , including throwing, kicking, picking up and dancing. You can even program your own function which, sadly, does not include doing windows. $99; robosapienonline.com. 4. MINI PEDAL CAR Want a Mini Cooper but can't fit the family inside? Get one for the kids. They can jump into this Mini car, which comes in hot orange with a single adjustable seat, and ride away. But it could spoil them for that used car they'll be driving when they turn 16.For ages 3 to 5.$189; minus A. com (click on "gear up," then "Mini motoring gear").
Output: Which toy is said to have the special design for children's safety?
Arthur Klemt (born 1913 in Offenburg, Baden-Wurttemberg, Germany -- died 1985 in Olching, Bavaria, Germany) was a German inventor.
Output: Where did Arthur Klemt live when he died?
China has become Volvo's third largest market, with more of its car models to go on sale in the world's largest auto market this year, Chief Executive Office (CEO) of Volvo Cars China said in Tianjin. Alexander Klose, CEO of Volvo Cars China, told Xinhua at the Ninth Tianjin International Automobile Trade Show, being held from Friday to Wednesday. Klose said Volvo Cars had entered a new time of fast development, adding that its sales volume in China in 2010. Up to the end of September, Volvo's global sales volume was up 12.5 percent year on year , compared with 52 percent year-on-year rise in China, he said. Two new Volvo sales centers opened in Beijing within merely one week in early October, about two months after east China's Zhejiang Geely Holding Group Co acquired the Swedish brand from the US auto giant Ford for $1.5 billion in early August. Klose said he was confident of seeing tremendous growth in China's auto market in the next five years. "As the Chinese government has increased the tax rate for large displacement cars already, we now have a lot of cars below three liters , and I think we'll stick to that strategy, as you can see now the XC60 which was introduced today is just two liters," he said. "As the technology advances, we'll probably even see 1.6 liter engines or 1.5 liter engines in the future," he added. Volvo Cars is not the only automaker hoping to take advantage of China's rapidly growing auto market. Bentley, the famous British luxury carmaker, will open a new sales center in China at Tianjin Thursday, which is the 11th one in China, according to a press release by Shanghai-based Zenith Integrated Communications Corp (Zenith) Saturday at the auto show. Zenth is the public relations agent of Bentley in China. The automaker has sold 421 limousines to China in 2009, and the goal for 2010 is 777, the release said.
Output: How many carmakers are mentioned in this passage which opened and will open new sales centers in China recently?
Jean-Francois Lyotard (French: ( fswa ljta); 10 August 1924 -- 21 April 1998) was a French philosopher, sociologist, and literary theorist.
Output: What is the language of Jean-François Lyotard?
Olympia Undae is a vast dune field in the north polar region of the planet Mars.
Output: On what celestial body is Olympia Undae located?
In week 12, the Lions flew east for another battle of division leaders, this time with the AFC East's 8-2 New England Patriots. The Lions failed to score a touchdown for the second consecutive week, and fell to second place after a blowout loss. The Lions scored first when Matt Prater hit a 48-yard field goal in the first quarter. The Patriots then took the lead which they kept for the rest of the game when Tim Wright caught a 4-yard touchdown pass from Tom Brady near the end of the first quarter. The Lions responded with a 20-yard field goal in the second quarter. The Patriots then scored two touchdowns on a 3-yard run from LeGarrette Blount, then an 8-yard catch by Tim Wright. New England's Stephen Gostkowski then kicked a 35-yard field goal to make the score 24-6 at halftime. The only score of the third quarter was a Patriots 35 yard field goal. In the final quarter, the Lions scored their third field goal, this one from 49 yards out. The Patriots capped their large victory with a 1-yard touchdown run from LeGarrette Blount.
Output: How far was Praters field goal in the first quarter?
One Saturday morning Ann was going on business. Before starting, she took her son Sam to her friends, Bill and Kate, and asked them to look after him for the day. Sam, an independent boy of six years old, had black hair and was wearing a pair of jeans and a bright yellow shirt. At eleven o'clock Bill took Sam into town. Sam walked along behind Bill, looking at the windows of all the shops they passed. After lunch they went to the park and walked about. The whole place was very crowded. Bill stopped to buy some chocolate. When he turned round to give some to Sam, the boy wasn't there. Bill ran round calling Sam, but he couldn't find him. About an hour later, just in front of a shop, he saw the black hair, the pair of jeans and the bright yellow shirt. The boy looked as if he was waiting for someone to come out of the shop. Bill ran across the road, took the boy by the hand and hurried off, as it was quite late. The boy began to cry and pull hard, but Bill, who didn't know much about children, couldn't understand a word the boy was saying. All the boy made was a lot of noise. When they got home at last, Bill went straight to the kitchen, with the boy still crying. At the door Bill stopped with an amazed look. There, sitting at the kitchen table with Kate, was a small boy with black hair, in a pair of jeans and a bright yellow shirt.
Output: What did Bill buy for Sam?
Beatrice Alda (born August 10, 1961; New York City, New York) is an American actress who appeared in The Four Seasons and Men of Respect and is the daughter of Alan and Arlene Alda.
Output: The person that is the mother of Beatrice Alda is who?
The Armed is a band from Detroit, Michigan playing a blend of hardcore punk and extreme metal since 2009.
Output: When was The Armed created?
The two most popular teams in Peru are Universitario and Alianza Lima. They are at the top of the polls conducted by many different groups. The group Apoyo, Opinion y Mercado in 2006 revealed that Alianza Lima was popular amongst 35%, followed by Universitario, with 32%. In 2005, a study by Grupo de Opinion Publica de la Universidad de Lima showed that Universitario was the most popular team in Lima and Callao with 31.7% followed by Alianza Lima with 29.3%. However, in 2006 and 2007 Alianza Lima appeared first in their polls. There was a narrow margin in 2007 as Alianza Lima reached 29.6% and Universitario followed with 29.5% under a margin of error of 4.16% In 2009, the universitys results varied because Alianza reached first with 40% and Universitario second with 35.5% under a margin of error of 4.47%. Another group known as CPI, revealed in May 2008 that Universitario was favored by 32% whilst Alianza Lima was favored by 33.5% under a margen of error of 2.7% at the national level. This report was divided into two parts. In the metropolitan capital, Universitario led with 42.8% and Alianza tailed behind with 39.9%. In the rest of the country, Universitario had a larger lead with 31.5% opposed to Alianzas 24.1%. In 2009, CPI released another poll indicating the Universitario was still the most popular team in Peru with 38.6% while Alianza reached 33.1%. A survey conducted by Grupo de Opinion Publica de la Universidad de Lima in February 2009, said that Alianza Lima ranked first in popularity with 27.2%; Universitario second with 26.6%. However, a second poll released by the same university group in September of the same year ranked Universitario first with 37.9% and Alianza second with 36.6%. The most recent report from the group indicates that Universitario has more sympathizers than Alianza with 40.6% over 36.% in the Province of Lima and Callao. On 2010, South American Football Confederation (Conmebol) stated that Universitario is the most popular team in Peru.
Output: In a 2005 poll, was Alianza Lima or Universitario more popular?
Hoping to build on their home win over the Jets, the Browns flew to Qualcomm Stadium to take on the throwback-clad San Diego Chargers. In the first quarter, things started off close with Chargers kicker Nate Kaeding getting a 29-yard field goal, while Browns kicker Phil Dawson nailed a 37-yarder. In the second quarter, Dawson would get a 20-yard field goal for Cleveland. However, San Diego got the first touchdown of the game, as LB Marques Harris recovered a fumble in the Browns endzone for a touchdown. Dawson would supply the scoring for Cleveland for the rest of the half, as he nailed a 42-yarder and a 30-yarder. In the third quarter, the Chargers gained some momentum, as RB LaDainian Tomlinson, after getting bottled up in the first half, broke out with a 41-yard TD run for the only score of the period. In the fourth quarter, Dawson would get another field goal, which came from 36 yards out. However, San Diego would respond with Tomlinson getting a 7-yard TD run. Cleveland would have Dawson get a 35-yard field goal, yet Tomlinson would get an 8-yard TD run, which was followed by a successful two-point conversion from QB Philip Rivers to WR Vincent Jackson. The Browns would finally get a touchdown, as QB Charlie Frye completed a 4-yard TD pass to WR Braylon Edwards. Unfortunately, the damage was already done. With the loss, Cleveland would fall to 2-6.
Output: Which team scored less points in the second quarter?
Stigler's law of eponymy is a process proposed by University of Chicago statistics professor Stephen Stigler in his 1980 publication ''Stigler's law of eponymy''.
Output: Who made the discovery of Stigler's law of eponymy?
Prior studies, all using SPECT techniques, failed to find any differences for dopamine transporter (DAT) in restless legs syndrome (RLS) subjects. The distinct pharmacokinetic properties associated with SPECT-determined DAT along with rapid biodynamic changes in DAT may, however, have missed membrane-bound DAT differences. The current studies assessed real-time DAT binding potentials (BP) in striatum of RLS patients using (11)C-methylphenidate and PET techniques. RLS medications were stopped at least 11 days prior to the PET study. Clinical severity of RLS was also assessed. PET scans were performed at 2 different times of day (starting at 08:30 and 19:30) in separate groups of subjects. The primary outcome measure was total striatal DAT BP. Thirty-six patients with primary RLS and 34 age- and gender-matched controls. RLS subjects had significantly lower DAT binding in the striatum compared to controls on both the Day and the Night scans. DAT was decreased in putamen and caudate but not the ventral striatum of RLS subjects. There were no diurnal differences in DAT for the total group or for control and RLS separately. DAT BP did not correlate with any clinical measures of RLS. The current study found a significant decrease in DAT BP in two independent studies. These results when viewed along with prior RLS SPECT and autopsy studies of DAT, and cell culture studies with iron deficiency and DAT, suggest that membrane-bound striatal DAT, but not total cellular DAT, may be decreased in RLS.
Output: Which deficiency is the cause of restless leg syndrome?
Gregory A. Feest (born 1956) is a United States Air Force Air Force major general who is currently serving as the Chief of Safety of the United States Air Force, Headquarters U.S. Air Force, Washington, D.C., and Commander, Air Force Safety Center, Kirtland Air Force Base, New Mexico.
Output: What military branch did Gregory A. Feest belong to?
Mosqueiro is an island near the south bank of the Para River in the Brazilian state of Para, roughly north of downtown Belem.
Output: What body of water was Mosqueiro next to?
Recent evidence suggests that abnormal activation of cyclin-dependent kinase 5 (cdk5) is a critical prodeath signal in stroke. However, the mechanism(s) by which cdk5 promotes death is unclear. Complicating the role of cdk5 are the observations that cdk5 can exist in multiple cellular regions and possess both prosurvival and prodeath characteristics. In particular, the critical role of cytoplasmic or nuclear cdk5 in neuronal jury, in vivo, is unclear. Therefore, we determined where cdk5 was activated in models of ischemia and how manipulation of cdk5 in differing compartments may affect neuronal death. Here, we show a critical function for cytoplasmic cdk5 in both focal and global models of stroke, in vivo. Cdk5 is activated in the cytoplasm and expression of DNcdk5 localized to the cytoplasm is protective. Importantly, we also demonstrate the antioxidant enzyme Prx2 (peroxiredoxin 2) as a critical cytoplasmic target of cdk5. In contrast, the role of cdk5 in the nucleus is context-dependent. Following focal ischemia, nuclear cdk5 is activated and functionally relevant while there is no evidence for such activation following global ischemia. Importantly, myocyte enhancer factor 2D (MEF2D), a previously described nuclear target of cdk5 in vitro, is also phosphorylated by cdk5 following focal ischemia. In addition, MEF2D expression in this paradigm ameliorates death. Together, our results address the critical issue of cdk5 activity compartmentalization, as well as define critical substrates for both cytoplasmic and nuclear cdk5 activity in adult models of stroke.
Output: What type of enzyme is peroxiredoxin 2 (PRDX2)?
Pont Boieldieu in Rouen, Rainy Weather is an 1896 painting by Camille Pissarro in the collection of the Art Gallery of Ontario.
Output: What is the name of the place where Pont Boieldieu in Rouen, Rainy Weather can be found?
The PLZ-45 or Type 88 is a 155 mm self-propelled howitzer designed by Su Zhezi of 674 Factory, and developed by Norinco, 123 Factory (Heilongjiang Hua'an Industry Group Company), 127 Factory (Tsitsihar Heping Machine Shop), 674 Factory (Harbin First Machine Manufacture Limited Company) and Beijing Institute of Technology in the early 1990s for the export market.
Output: Which company manufactured PLZ-45?
POV-Ray also could be ported to any platform which has a compatible C++ compiler.
Output: What is the programming language for POV-Ray?
It was built in 1923 with a 10,000-person capacity (seated and standing) to be the home arena of the NHL's Ottawa Senators by the Ottawa Auditorium Limited, a consortium controlled by T. Franklin Ahearn and Senators' owners Edgar Dey and Tommy Gorman.
Output: What team uses Ottawa Auditorium?
Zhelyo Zhelev (born 24 February 1987 in Stara Zagora) is a Bulgarian footballer currently playing for Vereya Stara Zagora as a midfielder.
Output: What is Zhelyo Zhelev's position in football?
Halo 4 was the first title released by 343 Industries in which they played a lead development role.
Output: What is the product of 343 Industries?
The original construction permit for the station was granted on July 1, 1983, and the WLKZ call letters were assigned on October 11; it took to the air on February 1, 1985, and a license to cover was granted on June 4, 1985.
Output: What is year of inception of WLKZ?
In Beverly Hills, California, wealthy heiress Vivian "Viv" Ashe leaves her richly pampered pet chihuahua, Chloe, with her irresponsible niece, Rachel, while she embarks on a business trip for ten days. Papi, the gardener Sam's pet Chihuahua of Mexican descent, has an unrequited crush on Chloe, by which she is disgusted. Rachel decides to go to Mexico with her friends and stay at a hotel by the beach. When Rachel leaves Chloe alone in the hotel room to go dancing at a club, Chloe goes looking for her. Chloe gets dog-napped as she tries to find Rachel and is sent to the dog fights in Mexico City. There, she meets a street-smart German Shepherd named Delgado. Rachel comes back to the hotel and is frantic when she finds Chloe missing. Chloe is picked to fight in the pit against El Diablo, a fierce Argentinean-Bolivian Doberman Pinscher. Delgado helps her escape the dog fights, unleashing the other dogs from their cages and unlocking the ring to allow both Chloe and himself to flee. After several arguments, he then decides to return her to Beverly Hills safely. Meanwhile, Rachel and Sam go to the Mexican police and offer rewards in an effort to find Chloe. El Diablo is sent by the dog fight ringleader, Vasquez, to capture Chloe and obtain the reward from Rachel. Delgado and Chloe arrive at Puerto Vallarta, where Chloe is caught by El Diablo but rescued. She then waits for Delgado to find help but is tricked into handing over her diamond-studded necklace to con artists Chico, an iguana, and Manuel, a pack rat who claims to be from the Yucutan. Chloe and Delgado sneak onto a train heading towards the border, but they are caught and are forced to jump out, eventually arriving in the barren deserts of Chihuahua, where Delgado explains that he was a former police dog; he was retired after he lost his sense of smell during a raid and a sneak attack from El Diablo. Rachel and Sam are in Puerto Vallarta and find that Chloe was spotted in the state of Chihuahua. After tracking Chloe and Delgado from Mexico City, El Diablo arrives in Chihuahua and attempts to capture Chloe, but Papi saves her and ends getting captured in a cage inside an abandoned Aztec temple, but Delgado comes to rescue the two and is briefly defeated. Chloe then rescues Papi, but Delgado discovers that El Diablo had vanished. Rachel finds Chloe, and Vasquez get arrested by the police. Chloe returns safely to Beverly Hills without Vivian finding out what happened and accepts a romantic relationship with Papi, as well as Rachel with Sam. The characters' fates are later revealed: Delgado returns to being a police dog in Mexico. El Diablo is recaptured by Delgado and is adopted by a rich lady who "had a passion for fashion". Chico and Manuel move to Beverly Hills and become rich. Papi and Chloe have their first date.
Output: What is the profession of Papi's master?
One Girl's Confession is a 1953 low-budget film noir released by Columbia Pictures.
Output: What company released One Girl's Confession?
Big Pumpkin is a children's book written by Erica Silverman, illustrated by S. D. Schindler, and published by Aladdin Paperbacks in 1992.
Output: What is the name of the publisher of Big Pumpkin?
The SWR1 complex (SWR1C) in yeast catalyzes the replacement of nucleosomal H2A with the H2AZ variant, which ensures full activation of underlying genes. We compared the phenotype of mutants in the homologs of SWR1C components in Arabidopsis thaliana. Mutations in Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1), homologs of SWC6, ARP6 and SWR1, respectively, caused similar developmental defects, including leaf serration, weak apical dominance, flowers with extra petals and early flowering by reduction in expression of FLOWERING LOCUS C (FLC), a strong floral repressor. Chromatin immunoprecipitation assays showed that AtSWC6 and SUF3 bind to the proximal region of the FLC promoter, and protoplast transfection assays showed that AtSWC6 colocalizes with SUF3. Protein interaction analyses suggested the formation of a complex between PIE1, SUF3, AtSWC6 and AtSWC2. In addition, H2AZ, a substrate of SWR1C, interacts with both PIE1 and AtSWC2. Finally, knockdown of the H2AZ genes by RNA interference or artificial microRNA caused a phenotype similar to that of atswc6 or suf3. Our results strongly support the presence of an SWR1C-like complex in Arabidopsis that ensures proper development, including floral repression through full activation of FLC.
Output: Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
Coming off their Sunday night road win over the Packers, the Cowboys went home for a Week 4 NFC East showdown with the Washington Redskins. In the first quarter, the 'Boys shot first as QB Tony Romo completed a 21-yard TD pass to TE Jason Witten. In the second quarter, the Redskins took the lead as QB Jason Campbell completed a 3-yard TD pass to WR James Thrash and a 2-yard TD pass to WR Antwaan Randle El, along with kicker Shaun Suisham getting a 20-yard field goal. Dallas closed out the half with kicker Nick Folk getting a 36-yard field goal. In the third quarter, the Cowboys tied the game with Romo completing a 10-yard TD pass to WR Terrell Owens. Washington would respond with Suisham kicking a 33-yard field goal. In the fourth quarter, the Redskins increased their lead with Suisham nailing a 33-yard and a 29-yard field goal. The 'Boys tried to rally as Romo completed an 11-yard TD pass to WR Miles Austin. However, Dallas' onside kick attempt failed, preserving the Redskins' win.
Output: Which player had a longer field goal kick in the second quarter?
Mercury is released into the atmosphere when coal is burned (Figure 1.1). But breathing the mercury is not harmful. In the atmosphere, the mercury forms small droplets that are deposited in water or sediments. Do you know why you are supposed to eat large predatory fish like tuna infrequently? It is because of the bioaccu- mulation of mercury in those species. Some pollutants remain in an organism throughout its life, a phenomenon called bioaccumulation. In this process, an organism accumulates the entire amount of a toxic compound that it consumes over its lifetime. Not all substances bioaccumulate. Can you name one that does not? Aspirin does not bioaccumulate; if it did, a person would quickly accumulate a toxic amount in her body. Compounds that bioaccumulate are usually stored in the organisms fat. In the sediments, bacteria convert the droplets to the hazardous compound methyl mercury. Bacteria and plankton store all of the mercury from all of the seawater they ingest (Figure 1.2). A small fish that eats bacteria and plankton accumulates all of the mercury from all of the tiny creatures it eats over its lifetime. A big fish accumulates all of the mercury from all of the small fish it eats over its lifetime. For a tuna at the top of the food chain, thats a lot of mercury. Historic increases of mercury in the atmo- sphere: blue is volcanic eruptions; brown, purple, and pink are human-caused. The red region shows the effect of industrial- ization on atmospheric mercury. So tuna pose a health hazard to anything that eats them because their bodies are so high in mercury. This is why the government recommends limits on the amount of tuna that people eat. Limiting intake of large predatory fish is especially important for children and pregnant women. If the mercury just stayed in a persons fat, it would not be harmful, but that fat is used when a woman is pregnant or nursing a baby. A person will also get the mercury into her system when she (or he) burns the fat while losing weight. Methyl mercury poisoning can cause nervous system or brain damage, especially in infants and children. Children may experience brain damage or developmental delays. The phrase mad as a hatter was common when Lewis Carroll wrote his Alice in Wonderland stories. It was based on symptoms suffered by hatters who were exposed to mercury and experienced mercury poisoning while using the metal to make hats (Figure 1.3). Like mercury, other metals and VOCS can bioaccumulate, causing harm to animals and people high on the food chain. Mercury, a potent neurotoxin, has been flowing into the San Francisco Bay since the Gold Rush Era. It has settled in the bays mud and made its way up the food chain, endangering wildlife and making many fish unsafe to eat. Now a multi-billion-dollar plan aims to clean it up. Click image to the left or use the URL below. URL:
Output: mercury poisoning can drive a person to be as mad as a hatter, which is based off of this novel.