niryuu/sni-each-converted huggingface dataset:
What's on ? The Conjuring 2 (2016) Certificate R 134 min--Horror Viewer points: 8.2 / 10 Lorraine and Ed Warren travel to north London to help a single mother raising four children alone in a house troubled by evil spirits . Director : James Wan Stars : Vera Farmiga , Patrick Wilson , Madison Wolfe , Frances O'Connor Warcraft (2016) Certificate PG-13 123 min--Action | Adventure | Fantasy Viewer points : 7.7 / 10 The peaceful land of Azeroth stands on the edge of war as its civilization faces a fearsome race of invaders : orc warriors escaping their dying home to conquer another . As a tunnel opens to connect the two worlds , one army faces destruction and the other faces extinction . From opposing sides , two heroes are set on a collision course that will decide the fate of their family , their people , and their home . Director : Duncan Jones Stars : Travis Fimmel , Paula Patton , Ben Foster , Dominic Cooper Now You See Me 2 (2016) Certificate PG-13 129 min--Action | Comedy | Thriller Viewer points : 7.1 / 10 The Four Horsemen resurface and are forcibly hired by a tech genius to pull off their most impossible magic show yet . Director : Jon M. Chu Stars : Jesse Eisenberg , Mark Ruffalo , Woody Harrelson , Dave Franco Me Before You (2016) Certificate PG-13 110 min--Drama | Romance Viewer points : 7.9 /10 A girl in a small town forms an unlikely bond with a recently-disabled man she's taking care of . Director : Thea Sharrock Stars : Emilia Clarke , Sam Claflin , Janet McTeer , Charles Dance
Output: Which actor will show in a movie that scares you ?
Hemingway & Gellhorn is an HBO biopic film about the lives of journalist Martha Gellhorn and her husband, writer Ernest Hemingway.
Output: The production company responsible for Hemingway & Gellhorn is what?
Mowat-Wilson syndrome is a recently delineated autosomal dominant developmental anomaly, whereby heterozygous mutations in the ZFHX1B gene cause mental retardation, delayed motor development, epilepsy and a wide spectrum of clinically heterogeneous features, suggestive of neurocristopathies at the cephalic, cardiac and vagal levels. However, our understanding of the etiology of this condition at the cellular level remains vague. This study presents the Zfhx1b protein expression domain in mouse embryos and correlates this with a novel mouse model involving a conditional mutation in the Zfhx1b gene in neural crest precursor cells. These mutant mice display craniofacial and gastrointestinal malformations that show resemblance to those found in human patients with Mowat-Wilson syndrome. In addition to these clinically recognized alterations, we document developmental defects in the heart, melanoblasts and sympathetic and parasympathetic anlagen. The latter observations in our mouse model for Mowat-Wilson suggest a hitherto unknown role for Zfhx1b in the development of these particular neural crest derivatives, which is a set of observations that should be acknowledged in the clinical management of this genetic disorder.
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Wolfgang Altmann (born 22 September 1952) is a retired German football midfielder.
Output: Which is the position of Wolfgang Altmann?
A similar fate met Jan Karski's older brother Colonel Marian Kozielewski, also a war hero.
Output: What is Jan Karski's brothers name?
Given the potential clinical benefit of inhibiting Na+/Ca2+ exchanger (NCX) activity during myocardial ischemia reperfusion (I/R), pharmacological approaches have been pursued to both inhibit and clarify the importance of this exchanger. SEA0400 was reported to have a potent NCX selectivity. Thus, we examined the effect of SEA0400 on NCX currents and I/R induced intracellular Ca2+ overload in mouse ventricular myocytes using patch clamp techniques and fluorescence measurements. Ischemia significantly inhibited inward and outward NCX current (from -0.04+/-0.01 nA to 0 nA at -100 mV; from 0.23+/-0.08 nA to 0.11+/-0.03 nA at +50 mV, n=7), Subsequent reperfusion not only restored the current rapidly but enhanced the current amplitude obviously, especially the outward currents (from 0.23+/-0.08 nA to 0.49+/-0.12 nA at +50 mV, n=7). [Ca2+]i, expressed as the ratio of Fura-2 fluorescence intensity, increased to 138+/-7% (P<0.01) during ischemia and to 210+/-11% (P<0.01) after reperfusion. The change of NCX current and the increase of [Ca2+]i during I/R can be blocked by SEA0400 in a dose-dependent manner with an EC50 value of 31 nM and 28 nM for the inward and outward NCX current, respectively. The results suggested that SEA0400 is a potent NCX inhibitor, which can protect mouse cardiac myocytes from Ca2+ overload during I/R injuries.
Output: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
A chip inserted in a young quadriplegic's brain is already improving his quality of life. Soon the benefits may be more widespread. A 25-year-old man unable to move from the neck down recently did what many assumed impossible. After a knife attack that had left him paralyzed, all he could move was his head, which he used to push a switch and call for a nurse. And he could turn his wheelchair by blowing into a straw near his face. That was it. Then last June, a Foxborough (Mass.) company called Cyber Kinetics opened the man's skull and inserted a special chip no larger than a baby aspirin. That insert has given him a few additional and precious abilities. When connected to a special computer via a cable, the chip translates the young man's thoughts into commands that let him move a cursor across a PC screen and open e-mail. He can draw a circle with a computer painting program. And he can use a robotic hook to perform simple tasks like picking up a candy and sliding it across a table. All he has to do is to think. Several new studies have begun or been completed in the past year. In fact, more than half of the scientific papers in this field, called brain-to-computer interaction (BCI), have been published in the past two years, notes Jonathan Wolpaw, a research physician at Wadsworth Center, the New York State Health Dept.'s research laboratory. Brain surgeries are no longer rare: Thousands of Parkinson's disease patients have had special devices inserted in their brains to ease uncontrollable shaking and other symptoms. The inserts themselves have improved, so the body doesn't reject them as furiously . And significant development has been achieved in software used to interpret the brain's signals and change them into commands understood by computers. But increased demand for thought technology remains the biggest reason for the field's progress. Today, 4 million Americans live with paralysis according to the Christopher Reeve Paralysis Foundation. Scientists hope that thought technology will reduce the impact of such disabilities. People with spinal-cord injuries, for example, often lose their ability to walk because the communications network between their brain and their legs has been interrupted. The brain still commands the leg muscles to move, but they don't hear its orders. Thought technology, scientists hope, will bridge this communications gap. "Our goal is for you to see paralyzed people eating at a restaurant and for you not to know that they are paralyzed," says John Donoghue, founder and chief scientific officer at Cyber Kinetics.
Output: What plays the most important role in improving the young man's quality of life?
30 Herculis (30 Her), or g Herculis, is a star in the constellation Hercules.
Output: Which was the constellation for 30 Herculis?
Fifteen women with a clinical and urodynamic diagnosis of stress urinary incontinence had a negative Q-tip test (greater than or equal to 30 degrees Q-tip angle change on straining). All 15 had retropubic surgical procedures for stress incontinence in the form of a revised Pereyra procedure (n = 6) or Burch retropubic urethropexy (n = 9). Five of the nine patients undergoing the Burch procedure (55%) and three of the six undergoing the Peyreya procedure (50%) failed the procedure, for an overall failure rate of 53%. This rate was five times higher than that among women with stress urinary incontinence and a positive Q-tip test who underwent the same procedures (P less than .01). We conclude that women with stress urinary incontinence and no anatomic defect in the support of the urethrovesical junction should not undergo retropubic procedures because of their high failure rate. Other occlusive procedures, such as sling operations, should be considered for this group.
Output: Which type of urinary incontinence is diagnosed with the Q tip test?
German academics believe they have solved the centuries-old mystery of the "Mona Lisa" in Leonardo ad Vinci's famous portrait . Lisa Gherardini, the wife of a wealthy Florentine merchant, Francesco del Giocondo, has long been seen as the most likely model for the sixteenth-century painting. Art historians have wondered whether the smiling woman may actually have been da Vinci's lover or mother, or the artist himself. Now experts at the prefix = st1 /HeidelbergUniversitylibrary say old notes made in a book by its owner in October, 1503, confirm that Lisa del Giocondo was indeed the model for the famous portrait in the world. "All doubts about the identity of the Mona Lisa have been removed by a discovery by Dr. Armin Schlechter," the library said in a statement on Monday. "Until then, only 'scant evidence' from sixteenth-century documents had been available. These had left lots of room for doubt, and many different identities were put forward." The comments compare Leonardo to the ancient Greek artist Apelles, and say he was working on three paintings at that time, one of which was a portrait of Lisa del Giocondo. Art experts say the Heidelbergdiscovery is a break-through, and the earliest mention linking the merchant's wife to the portrait. Before this discovery the earliest link dated from around 1550, and was made by Italian official Giorgio Vasari, the library said, adding that there had been doubts about Vasari's reliability. The Heidelbergnotes were actually discovered over two year's ago in the library by Schlechter, a spokeswoman said. Although the findings were published in the library's catalogue, they were not widely publicized, and received little attention until a German broadcaster decided to do some recording there, she said.
Output: Who discovered the Heidelbergnotes?
The FOXP2 gene is important for the development of proper speech motor control in humans. However, the role of the gene in general vocal behavior in other mammals, including mice, is unclear. Here, we track the vocal development of Foxp2 heterozygous knockout (Foxp2+/-) mice and their wildtype (WT) littermates from juvenile to adult ages, and observe severe abnormalities in the courtship song of Foxp2+/- mice. In comparison to their WT littermates, Foxp2+/- mice vocalized less, produced shorter syllable sequences, and possessed an abnormal syllable inventory. In addition, Foxp2+/- song also exhibited irregular rhythmic structure, and its development did not follow the consistent trajectories observed in WT vocalizations. These results demonstrate that the Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice, and that Foxp2 mutant mice may provide a tractable model system for the study of the gene's role in general vocal motor control.
Output: Which gene is responsible for proper speech development?
Eugene Brieux died in 1932 and was interred in the Cimetiere du Grand Jas in Cannes on the French Riviera.
Output: The final resting place of Eugène Brieux is at what cemetery?
Stefan Uros II Milutin (Serbian Cyrillic: II ; c. 1253 -- 29 October 1321), known as Stefan Milutin ( ), was the King of Serbia between 1282--1321, a member of the Nemanjic dynasty.
Output: What was the noble family that Stefan Milutin was from?
Islamey (subtitled Oriental Fantasy), Op. 18, is a composition for piano by Russian composer Mily Balakirev, written in September 1869.
Output: What instrument is Islamey scored for?
Muthukulikka Vaariyala is a 1995 Tamil language drama film directed by K. S. Ravikumar.
Output: What is the director of Muthukulikka Vaariyala?
The Ehlers-Danlos syndromes (EDS) are a group of heritable connective tissue disorders that share the common features of skin hyperextensibility, articular hypermobility, and tissue fragility. Considerable clinical and genetic heterogeneity exists, and more than nine separate forms have been recognized. Recent advances in the molecular analysis of EDS have identify defects responsible for EDS VI (homozygous and compound heterozygous mutations in the lysyl-hydroxylase gene), EDS VIIA and EDS VIIB (mutations in the type I collagene genes), EDS VIIC (deficiency of procollagen N-proteinase), EDS IX (mutations in the MNK gene), and EDS IV (mutations in the type III collagen gene). Of the various types of Ehlers-Danlos syndrome the most severe is type IV (EDS IV). Early studies showed that fibroblasts from EDS IV patients secreted lower than normal amounts of type III procollagen (Pope et al., 1975). Later, the disease was linked to COL3A1, the gene encoding this protein. More recently, with the publication of full length cDNA and partial characterisation of the gene structure, detailed analysis of mutations in EDS IV patients has become possible. Nineteen different mutations in the type III procollagen gene have been reported in different families with EDS IV. Recent results support the hypothesis that in EDS IV, dominant inheritance should be assumed, in sporadic cases also, unless proven otherwise. Very little is known about the genetics or biochemicals defects responsible for the others EDS subtypes, but with the applications of the tools of molecular biology, analysis of these defects if now within reach.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
Centrosome forms the backbone of cell cycle progression mechanism. Recent debates have occurred regarding the essentiality of centrosome in cell cycle regulation. CEP family protein is the active component of centrosome and plays a vital role in centriole biogenesis and cell cycle progression control. A total of 31 proteins have been categorized into CEP family protein category and many more are under candidate evaluation. Furthermore, by the recent advancements in genomics and proteomics researches, several new CEP proteins have also been characterized. Here we have summarized the importance of CEP family proteins and their regulation mechanism involved in proper cell cycle progression. Further, we have reviewed the detailed molecular mechanism behind the associated pathological phenotypes and the possible therapeutic approaches. Proteins such as CEP57, CEP63, CEP152, CEP164, and CEP215 have been extensively studied with a detailed description of their molecular mechanisms, which are among the primary targets for drug discovery. Moreover, CEP27, CEP55, CEP70, CEP110, CEP120, CEP135, CEP192, CEP250, CEP290, and CEP350 also seem promising for future drug discovery approaches. Since the overview implicates that the overall researches on CEP proteins are not yet able to present significant details required for effective therapeutics development, thus, it is timely to discuss the importance of future investigations in this field.
Output: Where in the cell do we find the protein Cep135?
With so many species of bacteria, some are bound to be harmful. Harmful bacteria can make you sick. They can also ruin food and be used to hurt people. There are also ways that bacteria can be harmful to humans and other animals. Bacteria are responsible for many types of human illness ( Figure 1.1), including: Strep throat Tuberculosis Pneumonia Leprosy Lyme disease Luckily most of these can be treated with antibiotics, which kill the bacteria. It is important that when a medical doctor prescribes antibiotics for you, you take the medicine exactly as the doctor tells you. You need to make sure the bacteria is killed. Bacterial contamination of foods can lead to digestive problems, an illness known as food poisoning. Raw eggs and undercooked meats commonly carry the bacteria that can cause food poisoning. Food poisoning can be prevented by cooking meat thoroughly, which kills most microbes, and washing surfaces that have been in contact with raw meat. Washing your hands before and after handling food also helps prevent contamination. Some bacteria also have the potential to be used as biological weapons by terrorists. An example is anthrax, a disease caused by the bacterium Bacillus anthracis. Inhaling the spores of this bacterium can lead to a deadly infection, and, therefore, it is a dangerous weapon. In 2001, an act of terrorism in the United States involved B. anthracis spores sent in letters through the mail. KidsHealth Food Poisoning at [Link] . 1. What are the common bacteria that cause food poisoning? 2. What steps can you take to keep your food safe?
Output: what part of a bacterium can be deadly?
Nelson Goncalves died of a heart attack at the age of 79.
Output: What was Nelson Gonçalves cause of death?
SpyParty is an indie video game currently being developed by Chris Hecker.
Output: Which company developed SpyParty?
Turner syndrome (TS) is the most common genetic problem affecting women and occurs when an X chromosome is completely deleted, portions of an X chromosome are deleted, or chromosomal mosaicism occurs. Girls with TS may also have occult Y chromosome sequences. Whereas some girls with TS are identified in infancy or early childhood, many girls with TS are not detected until after 10 yr of age, resulting in delayed evaluation and treatment. To prevent the delayed recognition and treatment of TS, a quantitative method of genotyping that can be performed as part of newborn screening is needed. To screen for sex chromosome abnormalities, we assembled a panel of informative single nucleotide polymorphism (SNP) markers that span the X chromosome from the dbSNP database. Pyrosequencing assays suitable for quantitative assessment of signal strength from single nucleotides were designed and used to genotype 46,XX; 46,XY; 45,X; and TS mosaics, examining zygosity and signal strength for individual alleles. Pyrosequencing assays were also designed for the detection of Y chromosome material. With just four informative SNP markers for the X chromosome, all TS girls with 45,X, partial X chromosome deletions, or mosaicism were identified with 100% sensitivity. In mosaic individuals, Y chromosomal material was detected with 100% sensitivity. These results suggest that inexpensive high-throughput screening is possible for TS and other sex chromosome disorders using quantitative genotyping approaches.
Output: What chromosome is affected in Turner's syndrome?
Robert Edward Chambliss (January 14, 1904 -- October 29, 1985), also known as Dynamite Bob, was convicted in 1977 of murder for his role as conspirator in the 16th Street Baptist Church bombing in 1963.
Output: Which crime led to the conviction of Robert Edward Chambliss?
The Penny Plunderer (Joe Coyne) is a fictional criminal in the DC Universe, and an adversary of Batman.
Output: What fictional universe is Penny Plunderer a part of?
Not so long ago almost student who successfully completed a university degree could find a good career quite easily. However. those days are gone, even in Hong Kong, and nowadays graduates often face strong competition in the search for jobs. Job seekers first have to make a careful assessment of their own abilities. One area of assessment should be of their academic qualifications, which would include special skills within their subject area. Graduates should also consider their own personal values and attitudes, or the importance to themselves of such matters as money, security, leadership and caring for others. The second stage is to study the opportunities available for employment. Job application forms and letters should, of course, be filled in carefully and correctly, without grammar or spelling errors. When graduates are asked to attend for interview, they should prepare properly by finding out all they can about the prospective employer. Dressing suitably and arriving for the interview on time are also obviously important. Interviewees should try to give positive and helpful answers and should not be afraid to ask questions about anything they are unsure about. This is much better than pretending to understand a question and giving an unsuitable answer. It is true that it is hard to find a good job. But there will always be good career opportunities for people with ability, skills and determination; the secret to securing good jobs in to be one of them.
Output: What is the most possible title of the passage?
Riociguat (Adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Output: What is generic name of drug Adempas?
Speaking and Reading In learning a foreign language, one should first pay attention to speaking. It is the groundwork of reading and writing. You'd better try your best to speak. Don't be afraid of making mistakes. While you are doing this, a good exercise is to write --keep a diary, write notes or letters and so on. Many mistakes in your speaking will be easily found when you write. Through correcting the mistakes, you can do better in learning a language. If you are slow in speaking, don't worry. One of the helpful ways is to improve your English by reading, either aloud or low to yourself. The important thing is to choose something interesting to read. It mustn't be too difficult for. When you are reading in this way, don't stop to look up the words if you can guess their meaning of if they are not important to the sentence. You can do that some other time.
Output: Which is the groundwork while you are learning a foreign language?
According to Apollodorus, Agenor was born in Memphis of Egypt to Poseidon and Libya and he had a twin brother named Belus.
Output: What was the name of Agenor mother?
Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, associated physical malformations and a predisposition to cancer. DBA has been associated with mutations and deletions in the large and small ribosomal protein genes, and genetic aberrations have been detected in 50-60% of patients. In this study, nine Korean DBA patients were screened for mutations in eight known DBA genes (RPS19, RPS24, RPS17, RPS10, RPS26, RPL35A, RPL5 and RPL11) using the direct sequencing method. Mutations in RPS19, RPS26 and RPS17 were detected in four, two and one patient, respectively. Among the mutations detected in RPS19, two mutations were novel (c.26T>A, c.357-2A>G). For the mutation-negative cases, array-CGH analysis was performed to identify copy-number variations, and no deletions involving the known DBA gene regions were identified. The relative mRNA expression of RPS19 estimated using real-time quantitative PCR analysis revealed two- to fourfold reductions in RPS19 mRNA expression in three patients with RPS19 mutations, and p53 protein expression analysis by immunohistochemistry showed variable but significant nuclear staining in the DBA patients. In conclusion, heterozygous mutations in the known DBA genes RPS19, RPS26 and RPS17 were detected in seven out of nine Korean DBA patients. Among these patients, RPS19 was the most frequently mutated gene. In addition, decreased RPS19 mRNA expression and p53 overexpression were observed in the Korean DBA patients, which supports the hypothesis that haploinsufficiency and p53 hyperactivation represent a central pathway underlying the pathogenesis of DBA.
Output: In which syndrome is the RPS19 gene most frequently mutated?
Cis-regulatory modules are non-protein-coding regions of DNA essential for the control of gene expression. One class of regulatory modules is embryonic enhancers, which drive gene expression during development as a result of transcription factor protein binding at the enhancer sequences. Recent comparative studies have begun to investigate the evolution of the sequence architecture within enhancers. These analyses are illuminating the way that developmental biologists think about enhancers by revealing their molecular mechanism of function.
Output: Are human enhancers or promoters evolving faster?
The relevance of the Simpson grading system as a predictor of meningioma progression or recurrence in modern neurosurgical practice has recently been called into question. The aim of our study was to compare the risk of progression/recurrence of tumours that had been treated with different Simpson grade resections in a contemporary population of benign (WHO grade I) meningioma patients. One hundred eighty-three patients with histologically confirmed WHO grade I meningioma were retrospectively analysed. All patients underwent first-time craniotomy as their initial therapy between 2004 and 2012. Univariate analysis was performed using log-rank testing and Kaplan-Meier analysis for progression/recurrence-free survival. Multivariate analysis was performed using Cox proportional hazards regression modelling. The three-year progression/recurrence-free survival rates for patients receiving Simpson grade 1, 2 or 4 resections were 95 %, 87 % and 67 %, respectively. Simpson grade 4 resections progressed/recurred at a significantly greater rate than Simpson grade 1 resections (hazard ratio [HR]=3.26, P=0.04), whereas Simpson grade 2 resections did not progress/recur at a significantly greater rate than Simpson grade 1 resections (HR=1.78, P=0.29). Subtotal resections progressed/recurred at a significantly greater rate than gross-total resections (HR=2.47, P=0.03). Tumours that undergo subtotal resection are at a significantly greater risk of progression/recurrence than tumours that undergo gross-total resection. Gross-total resection should therefore be the aim of surgery. However, given modern access to follow-up imaging and stereotactic radiosurgery, these results should not be used to justify overly 'heroic' tumour resection.
Output: Simpson grading is used to describe resection of which brain tumor?
Interleukin-1 (IL-1) is a key orchestrator in inflammatory and several immune responses. IL-1 exerts its effects through interleukin-1 receptor type I (IL-1RI) and interleukin-1 receptor accessory protein (IL-1RAcP), which together form a heterotrimeric signaling-competent complex. Canakinumab and gevokizumab are highly specific IL-1 monoclonal antibodies. Canakinumab is known to neutralize IL-1 by competing for binding to IL-1R and therefore blocking signaling by the antigen:antibody complex. Gevokizumab is claimed to be a regulatory therapeutic antibody that modulates IL-1 bioactivity by reducing the affinity for its IL-1RI:IL-1RAcP signaling complex. How IL-1 signaling is affected by both canakinumab and gevokizumab was not yet experimentally determined. We have analyzed the crystal structures of canakinumab and gevokizumab antibody binding fragment (Fab) as well as of their binary complexes with IL-1. Furthermore, we characterized the epitopes on IL-1 employed by the antibodies by NMR epitope mapping studies. The direct comparison of NMR and X-ray data shows that the epitope defined by the crystal structure encompasses predominantly those residues whose NMR resonances are severely perturbed upon complex formation. The antigen:Fab co-structures confirm the previously identified key contact residues on IL-1 and provide insight into the mechanisms leading to their distinct modulation of IL-1 signaling. A significant steric overlap of the binding interfaces of IL-1R and canakinumab on IL-1 causes competitive inhibition of the association of IL-1 and its receptor. In contrast, gevokizumab occupies an allosteric site on IL-1 and complex formation results in a minor reduction of binding affinity to IL-1RI. This suggests two different mechanisms of IL-1 pathway attenuation.
Output: Which molecule is targeted by the drug Gevokizumab?
When we are unfamiliar with something,we may feel nervous and fearful.The assistance of others is a good way to help us pull through. I write for a big newspaper, and I wanted to write a story about parachute jumping.To make it a realistic as well as exciting story,I decided that I first had to make a jump myself. Unfortunately,I am not good at any sports of any kind,let alone parachute jumping. My friend Mr. Smith was willing to give me a hand.He took me to a ground school.The first day's training included several hours of instruction but not my first drop from an airplane For this,I had to wait until the following morning. The next morning,after a hurried,anxious breakfast,I was taken to the airfield.There,two heavy parachutes were put on my back,and an orange helmet was pushed down onto my head.Then I was asked to make my way to a small plane which had just stopped slowly on the runway. Once on board,the plane was soon climbing.I began to feel nervous.As we reached one thousand metres,Harry,my teacher, hooked a line from my parachute to a steel ring inside the plane.The line was to pull my parachute open after I jumped. "Get ready, Henry,"Harry said.I moved carefully to the door.I wanted to cry,"No,no,no!"But no word came. "Jump!"Harry called loudly."Jump!" To my surprise,kicking like a frog I did jump.Away from the plane,and down,down I fell,arms stretched.It worked! The air seemed to hold me up.All at once I was very happy. Then I felt a quick pull.My big parachute had opened! It was the best surprise I ever had. I looked down.There were rivers,trees,fields and houses.I heard the soft sound of the air This was fun !
Output: How did the writer feel after he jumped out of the plane?
Ellen Horn (born Stoesen, 1 February 1951 in Montreal, Canada) is a Norwegian actress, theater director, and politician for the Labour Party.
Output: What is the place of birth of Ellen Horn?
Bringing Up Bobby is a 2009 Christian direct-to-video comedy film directed by Chris Staron.
Output: What was the year of Bringing Up Bobby?
Previous studies in vivo reported that processing of primary microRNA (pri-miRNA) is coupled to transcription by RNA polymerase II (RNAP II) and can occur co-transcriptionally. Here we have established a robust in vivo system in which pri-miRNA is transcribed by RNAP II and processed to pre-miRNA in HeLa cell nuclear extracts. We show that both the kinetics and efficiency of pri-miRNA processing are dramatically enhanced in this system compared to that of the corresponding naked pri-miRNA. Moreover, this enhancement is general as it occurs with multiple pri-miRNAs. We also show that nascent pri-miRNA is efficiently processed before it is released from the DNA template. Together, our work directly demonstrates that transcription and pri-miRNA processing are functionally coupled and establishes the first in vivo model systems for this functional coupling and for co-transcriptional processing.
Output: Which polymerase transcribes pri-miRNAs?
Udayananu Tharam (English: Udayan Is the Star) is a 2005 Malayalam black comedy film directed by Rosshan Andrrews and co-written by Sreenivasan.
Output: Who was Udayananu Tharam directed by?
Coexpression of PU.1 and GATA-1 is required for proper specification of the mast cell lineage; however, in the myeloid and erythroid lineages, PU.1 and GATA-1 are functionally antagonistic. In this study, we report a transcriptional network in which PU.1 positively regulates GATA-1 expression in mast cell development. We isolated a variant mRNA isoform of GATA-1 in murine mast cells that is significantly upregulated during mast cell differentiation. This isoform contains an alternatively spliced first exon (IB) that is distinct from the first exon (IE) incorporated in the major erythroid mRNA transcript. In contrast to erythroid and megakaryocyte cells, in mast cells we show that PU.1 and GATA-2 predominantly occupy potential cis-regulatory elements in the IB exon region in vivo. Using reporter assays, we identify an enhancer flanking the IB exon that is activated by PU.1. Furthermore, we observe that in PU.1(-/-) fetal liver cells, low levels of the IE GATA-1 isoform is expressed, but the variant IB isoform is absent. Reintroduction of PU.1 restores variant IB isoform and upregulates total GATA-1 protein expression, which is concurrent with mast cell differentiation. Our results are consistent with a transcriptional hierarchy in which PU.1, possibly in concert with GATA-2, activates GATA-1 expression in mast cells in a pathway distinct from that seen in the erythroid and megakaryocytic lineages.
Output: Which gene controls the expression of GATA-1 isoforms?
The Cistercian Abbey of Woney (Irish, Mainistir Uaithne), also written Wotheny or Owney, on the banks of the Mulkear River in Abington, County Limerick, was founded in 1205 when Theobald Walter (le Botiller) granted the whole ''theodum'' (believed to be an error, which should have been feodum) of Woodenikuwice for the purpose.
Output: What body of water was Abbey of Woney next to?
Previously, using a chromosomal reversion assay system, we established that an adaptive mutagenic process occurs in nongrowing Bacillus subtilis cells under stress, and we demonstrated that multiple mechanisms are involved in generating these mutations (41, 43). In an attempt to delineate how these mutations are generated, we began an investigation into whether or not transcription and transcription-associated proteins influence adaptive mutagenesis. In B. subtilis, the Mfd protein (transcription repair coupling factor) facilitates removal of RNA polymerase stalled at transcriptional blockages and recruitment of repair proteins to DNA lesions on the transcribed strand. Here we demonstrate that the loss of Mfd has a depressive effect on stationary-phase mutagenesis. An association between Mfd mutagenesis and aspects of transcription is discussed.
Output: In which phase of cell cycle does  stress-induced transcription-associated mutagenesis (TAM) occur?
In late 1532, Sawlon and Thohanbwa marched south and captured Prome.
Output: What was Sawlon's child's name?
The performance of two proteomic sample preparation methods, "pseudoshotgun" (PSG) and filter-aided sample preparation (FASP) were compared in terms of the number of identified proteins, representation of cellular component GO (gene ontology) categories in the obtained list of proteins, and the efficiency of both methods in the proteomic analysis of a very low number of cells. Both methods were combined to obtain a proteomic profile of a short-term culture (passage 3) of melanoma cells, established in our laboratory from a human metastatic melanoma lesion. The data revealed that with FASP, usually more proteins are identified than with PSG when analyzing a higher number of cells ( 5000/injection), whereas PSG is favorable when analyzing only a very small amount of cells (250-500/injection). PSG and FASP, however, are complementary techniques, as combining both methods further increases the number of identified proteins. Moreover, we show that it is feasible to identify a substantial number of proteins from only 250 cells/injection that is equivalent to 60 ng of protein.
Output: What is the method FASP used for?
In 1997 the Kymi Province was merged with the Uusimaa Province and the southern parts of the Hame Province into the new Southern Finland Province.
Output: What was replaced Kymi Province?
In 1949, Angela Hitler-Hammitzsch died after a stroke.
Output: The disease that Angela Hitler died of was what?
Mosquitoes have an extraordinary ability to target humans far away and fly straight to their unprotected skin. Regrettably,mosquitoes can do more than cause an itchy wound. Some mosquitoes spread several serious diseases,including Dengue,yellow fever and malaria. Over one million people worldwide die from these diseases each year. New research now shows how mosquitoes choose who to bite. Mosquitoes need blood to survive. They are attracted to human skin and breath. They smell the carbon dioxide gas,which all mammals breathe out. This gas is the main way for mosquitoes to know that a warm-blooded creature is nearby. But mosquitoes also use their eyes and sense of touch. Michael Dickinson is a professor at the California Institute of Technology. His research shows how these small insects,with even smaller brains,use three senses to find a blood meal. Michael Dickinson's team used plumes--a material that rises into the air of carbon dioxide gas into a wind tunnel. They then used cameras to record the mosquitoes. The insects followed the plume. Then,the scientists placed dark objects on the lighter colored floor and walls of the tunnel. Mr. Dickinson said,at first,the mosquitoes showed no interest in the objects at all. "What was quite striking and quite surprising is that the mosquitoes fly back and forth for hours. These are hungry females and they completely ignore the objects on the floor and wall of the tunnel. But the moment they get a hit of CO2,they change their behavior quite obviously and now would become attracted to these little visual blobs ." This suggested to the researchers that a mosquito's sense of smell is more important in the search for food. Once mosquitoes catch a smell of a human or animal,they also follow visual signals.
Output: What do mosquitoes mainly use to find their targets?
Names in Marble (Estonian: Nimed marmortahvlil) is an Estonian 2002 film directed by Elmo Nuganen.
Output: The film Names in Marble was directed by whom?
Everywhere man is altering the balance of nature.He is facilitating the spread of plants and animals into new regions, sometimes deliberately, sometimes unconsciously.He is covering huge areas with new kinds of plants, or with houses, factories, slag-heaps and other products of his civilization.He exterminates some species on a large scale, but favours the multiplication of others.In brief, he has done more in five thousand years to alter the biological aspect of the planet than has nature in five million. Many of these changes which he has brought about have had unforeseen consequences.Who would have thought that the throwing away of a piece of Canadian waterweed would have caused half the waterways of Britain to be blocked for a decade, or that the provision of pot cacti for lonely settlers' wives would have led to Eastern Australian being overrun with forests of Prickly Pear? Who would have prophesied that the cutting down of forests on the Adriatic coasts, or in parts of Central Africa, could have reduced the land to a semidesert, with the very soil washed away from the bare rock? Who would have thought that improved communications would have changed history by the spreading of disease-sleeping sickness into East Africa, measles into Oceania, very possibly malaria into ancient Greece? These are spectacular examples; but examples on a smaller scale are everywhere to be found.We make a nature sanctuary for rare birds, prescribing absolute security for all species; and we may find that some common and hardy kind of bird multiplies beyond measure and ousts the rare kinds in which we were particularly interested.We see, owing to some little change brought about by civilization, the starling spread over the English country-side in hordes.We improve the yielding capacities of our cattle; and find that now they exhaust the pastures which sufficed for less exigent stock.
Output: What have spread diseases?
To determine the appropriate method to calculate the rate of methicillin-resistant Staphylococcus aureus (MRSA) infection and colonization (hereafter, MRSA rates) for interhospital comparisons, such that the large number of patients who are already MRSA positive on admission is taken into account. A prospective, multicenter, hospital-based surveillance of MRSA-positive case patients from January through December 2004. Data from 31 hospitals participating in the German national nosocomial infections surveillance system (KISS) were recorded during routine surveillance by the infection control team at each hospital. Data for 4,215 MRSA-positive case patients were evaluated. From this data, the following values were calculated. The median incidence density was 0.71 MRSA-positive case patients per 1,000 patient-days, and the median nosocomial incidence density was 0.27 patients with nosocomial MRSA infection or colonization per 1,000 patient-days (95% CI, 0.18-0.34). The median average daily MRSA burden was 1.13 MRSA patient-days per 100 patient-days (95% CI, 0.86-1.51), with the average daily MRSA burden defined as the total number of MRSA patient-days divided by the total number of patient-days times 100. The median MRSA-days-associated nosocomial MRSA infection and colonization rate, which describes the MRSA infection risk for other patients in hospitals housing large numbers of MRSA-positive patients and/or many patients who were MRSA positive on admission, was 23.1 cases of nosocomial MRSA infection and colonization per 1,000 MRSA patient-days (95% CI, 17.4-28.6). The values were also calculated for various MRSA screening levels. The MRSA-days-associated nosocomial MRSA rate allows investigators to assess the extent of MRSA colonization and infection at each hospital, taking into account cases that have been imported from other hospitals, as well as from the community. This information provides an appropriate incentive for hospitals to introduce further infection control measures.
Output: What is MRSA?
It seems that beauty and women are twins.You are joking? No,I do not.Observe for yourself Ads on fashion TV screens,radio programs,magazines,newspapers,and the streets.Whether they have realized it or not, women are surrounded by a sea of fashion.They are taught to think that without beautiful clothes they will grow old and lose their charm.So who dares to neglect dressing up at the cost of their appearance and youth? But I do not agree with the opinion that women have to show their beauty through their looks.The richness of their minds proves to be more beautiful and attractive than their looks.A woman who has experienced many troubles and may be called "aunt" or "granny" can still keep up her beauty if she has such excellent qualities as knowledge,ability,a kind heart,great courage,concern for others,etc. In addition,old and young,beautiful and ugly are concept.People who keep a young mind will never feel old.Interested in new things and eager to learn more,they keep up with the tide.Plainly dressed women may have a type of beauty that is pure and real.Reading and learning is the best way to keep one youthful.Good books ale rich soil which can feed the flower of one's heart and looks.
Output: What is the best way for a woman to appear young according to the writer?
The Bearded Slave (Italian: Schiavo barbuto) is a marble sculpture by Michelangelo datable to around 1525--1530 and kept in the Galleria dell'Accademia in Florence.
Output: What is the name of the place where Bearded Slave can be found?
The 19th Light Dragoons was a cavalry regiment of the British Army created in 1781 for service in British India.
Output: What branch was 19th Light Dragoons part of?
From 2007 until 2012, the Pentagon's MRAP program deployed more than 12,000 MRAPs in the Iraq War and War in Afghanistan.
Output: What was the year that MRAP entered service?
Louis Philippe I (6 October 1773 -- 26 August 1850) was King of the French from 1830 to 1848 as the leader of the Orleanist party.
Output: What nationality was Louis Philippe I?
Somatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with the responses to the tyrosine kinase inhibitors gefitinib and erlotinib in patients with non-small-cell lung cancer (NSCLC). Although various methods for detecting EGFR gene mutations have been developed, they have several disadvantages. We attempted to establish a new method for the detection of EGFR gene mutations with the use of paraffin-embedded samples. The detections of T790M mutations in exon 20 and L858R mutations in exon 21 are based on the principle of allele-specific oligonucleotide polymerase chain reaction (PCR). We also designed PCR primers that enable to detect all types of deletions in exon 19. We assessed the basic performance efficiency of this method, and to confirm its clinical applicability, we performed PCR using DNA extracted from 66 tissue sections that were obtained from patients with NSCLC and embedded in paraffin. The sensitivity of this method for the detection of deletions or mutations was as low as 0.5%. In the 66 subjects whose samples were analyzed, we detected the following deletions and mutations in the EGFR gene: 11 deletions in exon 19, 8 L858R mutations, and 1 double mutation of L858R and T790M. The present method is sensitive and specific for the detection of deletions and mutations in the EGFR gene and is thus suitable for use in laboratory tests.
Output: Mutations in which gene determine response to both erlotinib and gefitinib?
The McLeod syndrome is a rare X-linked recessive disorder characterized by blood group, neuromuscular and haematopoietic abnormalities. It is caused by XK gene defects and may include large deletions in the Xp21 region. Analysis of three unrelated McLeod patients for the presence of the XK, DMD, CYBB, ETX1, RPGR and OTC loci, as well as for the DXS709 marker, revealed deletions from the 39th exon of DMD to the ETX1 locus (patient Be), from the XK to RPGR loci (patient Bi) and from the XK to CYBB loci (patient Lh). All three patients normally expressed the Lutheran (Lu) red cell antigens, thus excluding the interval between the RPGR and DMD genes as site of the XS locus, previously mapped to the Xp21.2-Xq21.1 region and thought to regulate the expression of the LU blood group gene on chromosome 19.
Output: Mutation of which gene is associated with McLeod syndrome?
Riociguat (Adempas(®)), a soluble guanylate cyclase stimulator, is a new, first-in-class drug approved for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) [inoperable or persistent/recurrent following surgery] or pulmonary arterial hypertension (PAH). It has been designated an orphan medicine by the European Medicines Agency and the US FDA. This article reviews the available pharmacological properties of oral riociguat and its clinical efficacy and tolerability in adults with CTEPH or PAH. Riociguat is effective and well tolerated in patients with inoperable CTEPH or persistent/recurrent CTEPH following pulmonary endarterectomy, and in patients with PAH. It has a positive result on exercise capacity and pulmonary haemodynamics, and improves WHO functional class. Most adverse events can be attributed to the vasodilatory mechanism of riociguat; however, there is a potential for serious bleeding and fetal harm, and riociguat use is contraindicated in pregnant patients. Pulmonary endarterectomy remains the first treatment of choice for CTEPH, as it is potentially curative. Head-to-head trials comparing riociguat with the approved phosphodiesterase type 5 inhibitors in patients with PAH would be of value for the placement of riociguat in the management of this disease. Riociguat is a promising addition to the treatment options for patients with CTEPH or PAH.
Output: What is generic name of drug Adempas?
Rhopalizus is a genus of round-necked longhorn beetles of the subfamily Cerambycinae.
Output: Is Rhopalizus a genus or species?