niryuu/sni-each-converted huggingface dataset:
A star usually is someone who has become famous in sports, film, or pop music, someone like singer Michael Jackson. In the middle nineteen eighties, Michael Jackson successfully made a famous record, which quickly became the most popular recording in the history of music. This made Michael Jackson a bright star. One of the famous sports bright stars in the United States is Mohammed Ali. When he was a young man, he won a gold medal in the Olympic Games as a boxer. Then, he won first place in the world heavy weight boxing match. Before long, he was known as one of the greatest and most famous boxers in sports history. Everyone knows his name. Like the stars in the sky, a bright star will lose his brightness as time passes. He is loved by millions of people today, but will be forgotten tomorrow.
Output: What does this passage mainly talk about?
Artangel is a London-based arts organisation founded in 1985 by Roger Took.
Output: What is the name of the founder of Artangel?
HD 113538 (Gliese 496.1) is a K-type main-sequence star of a late spectral type (K9V) that lies approximately 51 light-years away in the constellation of Centaurus.
Output: What is the name of the constellation where HD 113538 belongs?
Liberty Savage is a fictional character from the British Channel 4 soap opera Hollyoaks, played by actress and singer-songwriter Abi Phillips.
Output: In which fictional work is Liberty Savage a character?
Wizard101 launched a European Beta version on December 15, 2010 and then released the game on February 15, 2011, in partnership with Gameforge.
Output: Who published Wizard101?
Coming off their bye week, the Lions played a Week 5 Black and Blue Division duel at home with the Chicago Bears. In the first quarter, Detroit trailed early as Bears kicker Robbie Gould got a 37-yard field goal. In the second quarter, the Lions continued to trail as QB Kyle Orton completed a 9-yard TD pass to RB Matt Forte and a 12-yard TD pass to WR/KR Devin Hester. In the third quarter, Chicago continued its domination as Forte got a 1-yard TD run, and CB Charles Tillman returned an interception 26 yards for a touchdown. Afterwards, Detroit got its only score of the game as rookie RB Kevin Smith scored on a 12-yard TD run. In the fourth quarter, the Bears sealed the win when Gould nailed a 45-yard field goal.
Output: How was the ball received ending in the longest touchdown run?
Reprimo (RPRM), is a gene located at human chromosome 2q23 whose expression in conjunction with p53, along with other genes which are p53-induced, is associated with the arrest of the cell cycle at the G2 phase.Reprimo's protein product is a highly glycosylated polypeptide which, upon its expression, is localized to the cytoplasm where it is primarily active.
Output: What species is Reprimo specific to?
Nevertheless, the Marder II (and similar Marder III) provided a great increase in firepower over contemporary German tanks during 1942 and into 1943.
Output: Which was the official year for the approval of Marder II?
X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number of genes on the mouse X chromosome which escape X inactivation, and thus are expressed at higher levels in females, is very small. However this hypothesis has never been tested and only a small number of genes have been assayed for their X-inactivation status in the mouse. We performed a global expression analysis in four somatic tissues (brain, liver, kidney and muscle) of adult 40,XX and 39,XO mice using the Illumina Mouse WG-6 v1_1 Expression BeadChip and an extensive validation by quantitative real time PCR, in order to identify which genes are expressed from both X chromosomes. We identified several genes on the X chromosome which are overexpressed in XX females, including those previously reported as escaping X inactivation, as well as new candidates. However, the results obtained by microarray and qPCR were not fully concordant, illustrating the difficulty in ascertaining modest fold changes, such as those expected for genes escaping X inactivation. Remarkably, considerable variation was observed between tissues, suggesting that inactivation patterns may be tissue-dependent. Our analysis also exposed several autosomal genes involved in mitochondrial metabolism and in protein translation which are differentially expressed between XX and XO mice, revealing secondary transcriptional changes to the alteration in X chromosome dosage. Our results support the prediction that the mouse inactive X chromosome is largely silent, while providing a list of the genes potentially escaping X inactivation in rodents. Although the lower expression of X-linked genes in XO mice may not be relevant in the particular tissues/systems which are affected in human X chromosome monosomy, genes deregulated in XO mice are good candidates for further study in an involvement in Turner Syndrome phenotype.
Output: What chromosome is affected in Turner's syndrome?
The Abram Gaar House and Farm or known as the Gaar Mansion is a wooden Second Empire-style farm home located in Richmond, Indiana, built in 1876 and listed on the National Register of Historic Places.
Output: Of what style is Abram Gaar House and Farm?
The Narym River is a river in the Eastern Kazakhstan, a tributary of the Irtysh River, originating at the junction of the ridges Narym and Sarymsakty of wetland formed by the mountain runoff streams.
Output: The body of water that Narym River is near is what?
The Capitol Skyline Hotel is a hotel located near the United States Capitol in Capitol Hill, Washington, D.C. Designed by Morris Lapidus, the hotel opened in November 1962 as the Skyline Inn, and was once part of the Best Western chain.
Output: Who was the architect or designer of Capitol Skyline Hotel?
Friedrich-Wilhelm Graefe zu Baringdorf (born 29 November 1942 in Spenge) was Member of the European Parliament for the German political party Alliance '90/The Greens, part of the European Greens, from 1984 to 1987 and 1989 to 2009, and from 1996 to 2012 chairperson of the Arbeitsgemeinschaft bauerliche Landwirtschaft (ABL), an association for peasant-based or family-farming in Germany.
Output: What nationality was Friedrich-Wilhelm Graefe zu Baringdorf?
Sarifer is a genus of beetles in the family Cerambycidae, containing the following species:
Output: Is Sarifer a genus or species?
A study was performed to determine the utility of the 8-point recognition of stroke in the emergency room (ROSIER) instrument as a diagnostic tool in a large Irish emergency department. Fifty patients had ROSIER scores completed by doctors. Diagnoses achieved using the score were compared with discharge diagnoses. Relations between ROSIER score, impairment and length of stay were assessed. Forty-seven patients (94%) had a ROSIER Score > or =1 indicating a stroke, 44 (94%) of these had stroke confirmed on investigation. Two patients with stroke were missed and three were wrongly identified. Positive predictive value for the ROSIER was 94%. ROSIER correlated with Scandinavian neurological stroke score. (r = -0.414, p = 0.003) and was associated with increasing length of stay in survivors (p = 0.16, one-way ANOVA. F = 3.116, df = 6). The ROSIER is a suitable and useful adjunct in the assessment of stroke patients in Ireland.
Output: ROSIER scale is used for which disorder?
Rochester Cathedral, formally the Cathedral Church of Christ and the Blessed Virgin Mary, is an English church of Norman architecture in Rochester, Medway.
Output: The art style of Rochester Cathedral is what?
The Societa Valdostana Automobili (SVA), was an Italian automobile manufacturer, active in Pont Saint Martin from 1948 to 1951.
Output: What year did Societa Valdostana Automobili start?
Pedro Manrique de Lara (died January 1202), commonly called Pedro de Molina and usually known in French sources as Pierre de Lara, was a Castilian nobleman and military leader of the House of Lara.
Output: What family lineage was Pedro Manrique de Lara part of?
The Broncos made their first visit to Tampa Bay since 2004. Cornerback Aqib Talib, who made his return to Tampa Bay where he played for the Buccaneers from 2018-2012, intercepted Buccaneers' quarterback Jameis Winston on the third play of the opening drive. The Broncos immediately capitalized, with quarterback Trevor Siemian throwing an 11-yard touchdown to wide receiver Demaryius Thomas. On the Buccaneers' next drive, a 7-yard touchdown run by Winston tied the game, which would be the Buccaneers' only scoring play of the game. Following another interception of Winston by Talib, the Broncos re-claimed the lead, with a 1-yard touchdown run by running back C. J. Anderson. With 3:25 remaining in the first half, Siemian injured his non-throwing shoulder when he was sacked by defensive tackle Clinton McDonald, and backup quarterback Paxton Lynch, the team's first-round draft selection, took over in his NFL debut. Placekicker Brandon McManus added two field goalsa 38-yarder just before halftime and a 24-yarder midway through the third quarter. Lynch later threw his first touchdown passa 5-yarder to wide receiver Emmanuel Sanderswhich put the game out of reach. At the 6:52 mark of the fourth quarter, the game was delayed for an hour and a half due to a severe weather threat in the Tampa area.
Output: Which player scored the first rushing touchdown?
Turner syndrome is a chromosomal abnormality in which there is complete or partial absence of the X chromosome. Turner syndrome effects 1 in every 2000 live births. Short stature is a cardinal feature of Turner Syndrome and the standard treatment is recombinant human growth hormone. When growth hormone is started at an early age a normal adult height can be achieved. With delayed diagnosis young women with Turner Syndrome may not reach a normal height. Adjuvant therapy with oxandrolone is used but there is no consensus on the optimal timing of treatment, the duration of treatment and the long term adverse effects of treatment. The objective of this review and meta-analysis is to examine the effect of oxandrolone on adult height in growth hormone treated Turner syndrome patients. Eligible trials were identified by a literature search using the terms: Turner syndrome, oxandrolone. The search was limited to English language randomized-controlled trials after 1980. Twenty-six articles were reviewed and four were included in the meta-analysis. A random effects model was used to calculate an effect size and confidence interval. The pooled effect size of 2.0759 (95% CI 0.0988 to 4.0529) indicates that oxandrolone has a positive effect on adult height in Turner syndrome when combined with growth hormone therapy. In conclusion, the addition of oxandrolone to growth hormone therapy for treatment of short stature in Turner syndrome improves adult height. Further studies are warranted to investigate if there is a subset of Turner syndrome patients that would benefit most from growth hormone plus oxandrolone therapy, and to determine the optimal timing and duration of such therapy.
Output: What chromosome is affected in Turner's syndrome?
The State of Rhode Island has become a popular family seaside destination. In addition to beach activities and water sports, kids can participate in supervised activities at cultural centres and tourist attractions around the state. The Kayak Centre of Rhode Island The Kayak Centre of Rhode Island offers Oceanplay to kids, a program for children between 9 and 14 years old. The course teaches basic kayak skills and safety protocol on the waters around historic Wickford Village. The all-day program includes games and skill-building activities at all skill levels. The package includes equipment, instructions and lunch. The Courthouse Centre for the Arts The Courthouse Centre for the Arts offers summer camp educational workshops and fine arts programs to kids who want to learn about theatre, dance, classical music and different art mediums. Kids and families can also enjoy concerts, film screenings and theatre performances. The Providence Children's Museum The Providence Children's Museum hosts daily drop-in programs for kids between 5 and 11 years of age and museum adventure classes. Kids can learn how water moves in the Water Ways exhibit, listen to music and learn about plants in the Children's Garden exhibit. The RISD Museum The RISD Museum hosts family workshops and activities for kids between 5 and 12 years of age on alternating Sunday afternoons. Kids can learn different types of art techniques and work with different mediums in a supervised setting. Families taking a self-guided tour of the museum can see exhibits.
Output: What will a child interested in plants probably visit?
Agnes of Jesus, O.P., (born Agnes Galand and also known as Agnes of Langeac; November 17, 1602 -- October 19, 1634) was a French Catholic nun of the Dominican Order.
Output: What group was Agnes of Jesus a member of?
Over the next year, however, the Polish forces were subject to attrition, as the Sejm again refused to raise taxes and pay the army, resulting in mass desertions of unpaid soldiery. The Polish problems were further aggravated by the incompetent leadership of hetman Micha Kazimierz Pac, who obstructed Sobieski's leadership, while the Ottomans continued to receive reinforcements. Nonetheless in 1674 the Commonwealth resumed the offensive, taking advantage of a new Muscovy-Ottoman conflict that year, and the Polish-Ottoman war remained undecided.:275 Sobieski's force of 6,000 defeated 20,000 Turks and Tatars under Ibrahim Shyshman in the battle of Lwow in August 1675.:653 Even after the Battle of Trembowla, the Sejm still refused his pleas for more funds and a larger army.:653 In 1676, after Sobieski's 16,000 withstood the two-week siege of Zurawno, by 100,000 men under Ibrahim Pasha, a new peace treaty was signed, the Treaty of Zurawno.:655 The peace treaty partially reversing those from Buczacz: the Ottomans kept approximately two thirds of the territories they gained in 1672, and the Commonwealth no longer was obliged to pay any kind of tribute to the Empire; a large number of Polish prisoners were released by the Ottomans.
Output: Which happened first, the siege of Żurawno or the Treaty of Żurawno?
Sharp, Stewart and Company was a steam locomotive manufacturer, initially based in Manchester, England.
Output: What type of product does Sharp, Stewart and Company produce?
The 49ers featured one of the best running games in the NFL in 1976 NFL season. Delvin Williams emerged as an elite back, gaining over 1,200 yards rushing and made the Pro Bowl. Wilbur Jackson also enjoyed a resurgence, rushing for 792 yards. Once again Gene Washington was the teams leading receiver with 457 yards receiving and six scores. The 49ers started the season 61 for their best start since 1970. Most of the wins were against second-tier teams, although the 49ers did shut out the Rams 160, in 1976 Los Angeles Rams season on Monday Night Football. In that game the 49ers recorded 10 sacks, including 6 by Tommy Hart. However, the 49ers lost four games in a row, including two against divisional rivals Los Angeles and 1976 Atlanta Falcons season that proved fatal to their playoff hopes. Louis G. Spadia retired from the 49ers in 1977 upon the teams sale to the DeBartolo Family. The team was sold to Edward J. DeBartolo Jr. in March 1977, and despite finishing the season with a winning record of 86, Clark was fired after just one season by newly hired general manager Joe Thomas (American football executive), who oversaw the worst stretch of football in the teams history.
Output: What team did Delvin Williams play for?
The Siege of Paysandu began 3 December 1864, during the Uruguayan War, when Brazilian forces (under Marquis of Tamandare) and Colorado forces (under Venancio Flores) attempted to capture the city of Paysandu in Uruguay from its Uruguayan Army defenders.
Output: What year did Siege of Paysandú start?
Edward Percy Smith (5 January 1891 -- 27 May 1968) was a Conservative Party politician in the United Kingdom.
Output: Which political party was Edward Percy Smith a member of?
Love with the Proper Stranger is a 1963 romantic comedy drama film made by Pakula-Mulligan Productions and Boardwalk Productions and released by Paramount Pictures.
Output: Which was the production company for Love with the Proper Stranger?
Ginger Pye is a book by Eleanor Estes about a dog named Ginger Pye.
Output: Who was Ginger Pye illustrated by?
The Intriguers, first published in 1972, was the fourteenth novel in the Matt Helm spy series by Donald Hamilton.
Output: To which series does The Intriguers belong?
"Find a job you love, and you'll never work a day in your life." Do you agree with this old saying? Joanne Gordon does. She is the author of Be Happy at work and other books about careers . Gordon believes that about 30% of employees in North America do not like their jobs, and she thinks that is terrible. She wants to help people who do not feel satisfied with their jobs find work that is good for them. Joanne says, "There are no happy jobs, only happy workers." She believes that happy workers share three main characteristics. First, happy workers enjoy the daily activities of their jobs, and they look forward to the workday. Take Tony Hawk, for example. At age 14, he became a professional skateboarder. Now he is a businessman working on projects related to skateboarding--films and video games, but he still skates every day. He once said, "My youngest son's pre-school was recently asked what their dads do for work. My son said, 'I've never seen my dad do work.'" Tony agrees that his job doesn't look like work. He has found a way to spend each day doing a job he enjoys. Second, happy workers like the people they work with. Sally Ayote says, "I work with the coolest people in the world." She and her group cook for almost 1,200 people in Antarctica. Most of these people are scientists who are doing research. Sally loves to sit and talk with them. She says, "There is no television here, no radio, so I get to know the scientists and what they're studying." Sally thinks she has a great job, and the best part about it is the people. Third, happy workers know that their work helps others. Caroline Baron's work helps people who have had to leave their home countries because of war or other dangers. She is a filmmaker who started an organization called FilmAid, which shows movies in refugee camps around the world. Caroline believes that movies can be very helpful in these camps. For one thing, entertaining movies let refugees forget their troubles for a little while. Movies can also teach important subjects like health and safety. For example, in one camp, thousands of refugees saw a movie about how to get clean water. Caroline knows that is helping other people, and this makes her feel proud and happy about her work. Tony Hawk, Sally Ayote, and Caroline Baron all get great satisfaction from their work. Tony Hawk says, "Find the thing you love. If you are doing what you love, there is much more happiness there than being rich or famous." Joanne Gordon would agree. She encourages people to find something they enjoy doing, find people they like to work with, and find ways to help others. Then they can be proud of what they do, and they will probably be happy at work.
Output: Who is the book, Be Happy at Work, written for?
The Morupule Colliery is a coal mine located in Palapye, Botswana, and owned and operated by Debswana, a partnership between the government of Botswana and De Beers.
Output: The product of Morupule Colliery is what?
Iron depletion is common in regular blood donors. The objective of the study was to investigate the frequency and severity of iron depletion in regular blood donors and whether IV iron is more effective than oral to avoid iron depletion and symptoms thereof, especially restless legs syndrome (RLS). One hundred and twenty blood donors with at least five previous whole blood donations were randomized to receive either IV iron sucrose (Venofer(®), RenaPharma/Vifor, Uppsala, Sweden), 200 mg, or to 20100 mg of oral iron sulphate (Duroferon(®), GlaxoSmithKline, Stockholm, Sweden), after each blood donation during 1 year. Iron status and RLS incidence and severity were investigated. Iron status was generally poor among regular blood donors, especially in women, with a high incidence of iron depletion (>20%) and RLS (18%). The IV iron group increased storage iron to a greater extent than the oral iron group after 12 months (P=00043). Female donors were more responsive to IV iron sucrose compared to oral iron sulphate, particularly female donors below 50 years of age. RLS severity scores were significantly lower in the IV iron group. The two treatments were safe. Iron status is poor in regular blood donors, restless legs syndrome is common, and the routine iron supplementation is insufficient. IV iron sucrose substitutes iron loss in blood donors more efficiently compared with oral iron sulphate, especially in women. Iron substitution to blood donors should be individualized and based on P-ferritin monitoring.
Output: Which deficiency is the cause of restless leg syndrome?
Jean-Pierre Vande Velde (born 10 September 1955 in Belgium) is a former Belgian footballer, currently managing Temse in the Belgian Third Division after being fired from Union SG.
Output: What is Jean-Pierre Vande Velde's birthplace?
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is commonly seen in patients with end-stage renal disease (ESRD), but this condition has not been properly recognized. The prevalence of RLS/WED in ESRD shows the ethnic variation (7%-68%), with the similar tendency of primary RLS/WED. Although RLS/WED in ESRD is defined in secondary RLS/WED, the factors of ESRD that are involved in the genesis of RLS/WED remain unknown. Even after renal transplantation, RLS/WED symptoms do not completely disappear, and genetic predisposition to RLS/WED may play an important role in causing RLS/WED. Long-term intervention for RLS/WED and ESRD will be necessary.
Output: Willis-Ekbom disease is also known as?
More than one in eight U. S. adults finds it hard to stay away from the Internet for several days at a time and about one in eleven tries to hide his or her online habit, according to a study showed on Tuesday. The study by researchers from the Stanford University School of Medicine in California found one in eight adults admitted they needed to spend less time online, saying this showed "problematic Interact use" is present in a sizable portion of the population. The study involved a nationwide telephone survey of 2,581 respondents in the spring and summer of 2004 with researchers then examining the data and preparing the report which appears in the October issue of CNS Spectrums. The survey found that 68.9 percent of respondents were regular Internet users and 13.7 percent of the users found it hard to stay offline for several days at a time. It found 12.4 percent often stayed online longer than intended, more than 12 percent said they saw a need to cut back on their Internet use, and 8.7 percent tried to conceal "non-essential "Internet use from family, friends and employers. A smaller number, 8.2 percent, said they use the Internet to escape problems or a bad mood, while 5.9 percent felt their relationships suffered because of too much Internet use. One report published earlier this year said that 5 percent to 10 percent of the population likely will experience Internet addiction . It said signs include a disregard for health or appearance, lack of sleep and reducing physical activities and social communications with others, as well as dry eyes and juries of hands and fingers.
Output: Those who try to hide their habit of addition to the Interact make up of the respondents.
Maggiano is an award-winning teacher in the Social Studies Department at West Springfield High School in Virginia.He has taught in public and private schools for 25 years.In a piece on his blog called "The Classroom Post," he calls for more males to enter the profession . Men Teach, a non-profit organization that encourages men to enter teaching, reports that in 2008, 18.8% of all elementary and middle school teachers were men.At the high school level during the same year, men comprised 44% of the work force. Why are there so few men in teaching? Men Teach says low pay and lack of prestige , as well as a perception in our culture that teaching is for women.As a result, there is no organized effort across the country to attract men into the teaching profession. A study in 2008 by the National Education Association showed that the number of male teachers hit a record 40-year low.Males comprised 24.5 percent of public schoolteachers.States with high percentages: Kansas (33.6 percent), Oregon (31.6 percent), Alaska (30.9 percent) and Indiana (30.5percent).States with the lowest percentage : Arkansas (16.2 percent), Virginia (17.4 percent), Mississippi (17.5 percent), Louisiana (18 percent), South Carolina (18.5 percent) and Georgia (19.7 percent). There is no definitive research that male students--or female students, for that matter-- learn better from a particular sex. But as Maggiano put it, "Kids today, both boys and girls, must have the same opportunity to learn from outstanding, devoted men that I did.However, I have heard little discussion about this problem coming from our national leaders.
Output: In which state are male teachers most badly needed?
Carl Michael Bellman was born on 4 February 1740 in the Stora Daurerska house, which was one of the finest in the Sodermalm district of Stockholm.
Output: In what city did Carl Michael Bellman die?
THE SEVENTIES: When New York was still the greatest, dirtiest, most conflicted city in the world...At 16, socially responsible upper west-sider CHARLIE BANKS (Jesse Eisenberg), 15, witnesses charismatic blue collar sociopath MICK LEARY (Jason Ritter), 18, brutally beat two unwitting suburban jocks at a high school party. Mick's a west village neighborhood buddy of Charlie's best friend, but Charlies' conscience gets the better of him. Telling only his parents, he reports Mick to the police.Three years later, during his freshman year in college, Mick shows up for a visit. Does Mick know he was the one who ratted him out?Mick's visit stretches past the weekend and Mick and Charlie begin a game of cat and mouse. Nice one moment, and threatening the next, Mick keeps Charlie guessing. But Mick also begins a strange course of assimilation, donning borrowed cashmere and reading Charlie's books and auditing his classes. Soon Charlie begins to wonder if the intellectual caress of higher education can redeem even someone seemingly as far gone as Mick.
Output: Who shows up for a visit?
Mutations in the CLN3 gene, which encodes a lysosomal membrane protein, are responsible for the neurodegenerative disorder juvenile Batten disease. A previous study on the yeast homolog to CLN3, designated Btn1p, revealed a potential role for CLN3 in the transport of arginine into the yeast vacuole, the equivalent organelle to the mammalian lysosome. Lysosomes isolated from lymphoblast cell lines, established from individuals with juvenile Batten disease-bearing mutations in CLN3, but not age-matched controls, demonstrate defective transport of arginine. Furthermore, we show that there is a depletion of arginine in cells derived from individuals with juvenile Batten disease. We have, therefore, characterized lysosomal arginine transport in normal lysosomes and show that it is ATP-, v-ATPase- and cationic-dependent. This and previous studies have shown that both arginine and lysine are transported by the same transport system, designated system c. However, we report that lysosomes isolated from juvenile Batten disease lymphoblasts are only defective for arginine transport. These results suggest that the CLN3 defect in juvenile Batten disease may affect how intracellular levels of arginine are regulated or distributed throughout the cell. This assertion is supported by two other experimental approaches. First, an antibody to CLN3 can block lysosomal arginine transport and second, expression of CLN3 in JNCL cells using a lentiviral vector can restore lysosomal arginine transport. CLN3 may have a role in regulating intracellular levels of arginine possibly through control of the transport of this amino acid into lysosomes.
Output: What is the effect of a defective CLN3 gene?
To evaluate gender differences in score on 28-joint Disease Activity Score (DAS28), Health Assessment Questionnaire (HAQ) and Signals Of Functional Impairment (SOFI) and to relate these scores to radiographic joint destruction. In all, 549 patients with early RA (62% women) from the BARFOT (for "Better Anti-Rheumatic FarmacOTherapy") study were included. At baseline, 1, 2 and 5 years DAS28, HAQ and SOFI scoring, and radiographs of hands and feet were performed. The radiographs were scored using the van der Heijde-Sharp score. In women the DAS28 was significantly higher than in men due to higher scores for general health and tender joints. Likewise, HAQ and VAS pain were rated significantly higher in women. The SOFI score was worse in men during the first 2 years, depending on higher upper limb scores. Total Sharp score (TotSharp), erosion score and joint space narrowing score did not differ between the sexes at any time point. The DAS28 area under the curve (AUC) correlated significantly with TotSharp at 5 years in both genders (r = 0.316, r = 0.313) mainly owing to swollen joints and erythrocyte sedimentation rate (ESR). The SOFI AUC correlated significantly with TotSharp in women (r = 0.135 to 0.220) but not in men. Despite a similar degree of radiographic joint destruction women had, compared with men, worse scores for DAS28 and HAQ, possibly due to higher pain perception and less muscular strength and perhaps because men overestimate their functional capacity.
Output: Is Rheumatoid Arthritis more common in men or women?
Dystrophic myotonia is a sufficiently rare disease inherited mainly by the autosomal dominant type. Clinical picture is characterized by the myotonic, myopathic, and endocrine-autonomic syndrome. A clinical, genetic, and electromyographic study was carried out to elucidate the problem of this condition inheritance, its intra- and interfamilial clinical polymorphism, and effects of environmental factors on its course and outcomes.
Output: How is myotonic dystrophy inherited?
Dale Rasmussen (born 5 July 1977) is a former Samoan international rugby union player.
Output: What is Dale Rasmussen's sport?
The Philadelphia chromosome translocation (t(9;22)) results in the molecular juxtaposition of two genes, BCR and ABL, to form an aberrant BCR-ABL gene on chromosome 22. BCR-ABL is critical to the pathogenesis of chronic myelogenous leukemia and a subset of acute leukemias. The chimeric Bcr-Abl protein has constitutively elevated tyrosine phosphokinase activity. This abnormal enzymatic activation is critical to the oncogenic potential of Bcr-Abl. Initially, protein kinases were thought to be poor therapeutic targets because of their ubiquitous nature and crucial role in many normal physiologic processes. However, the advent of imatinib mesylate (Gleevec, Novartis Pharmaceuticals, Basel, Switzerland), formerly known as STI571 and CGP57148B, demonstrated that designer kinase inhibitors could be specific. This agent has shown striking activity in chronic myelogenous leukemia. It also inhibits phosphorylation of Kit (stem-cell factor receptor) and platelet-derived growth factor receptor. In addition, it has shown similar impressive responses, with little host toxicity, in gastrointestinal stromal tumors, which harbor activating Kit mutations, and in tumors with activated platelet-derived growth factor receptor. The studies of imatinib mesylate provide proof-of-principle for using aberrant kinases as a therapeutic target and are a model for the promise of molecular therapeutics. This paper reviews the current knowledge on the function of Bcr-Abl and its normal counterparts (Bcr and Abl), as well as the impact of this knowledge on the development of a remarkably successful targeted therapy approach.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Kachina Chasmata is the longest canyon or system of canyons on the surface of the Uranian moon Ariel.
Output: On what celestial body is Kachina Chasmata located?
The superoxide-producing phagocyte NADPH oxidase gp91(phox)/Nox2 and the non-phagocytic oxidases Nox1 and Nox3 each form a complex in the membrane with p22(phox), which provides both stabilization and a docking site for organizer proteins. The p22(phox)-complexed Nox2 and Nox1 are dormant on their own, and their activation requires soluble supportive proteins such as a Nox organizer (p47(phox) or Noxo1) and a Nox activator (p67(phox) or Noxa1). The small GTPase Rac directly binds to the activators, and thus plays an essential role in the Nox2-based oxidase containing p47(phox) and p67(phox) or a positive role in Nox1 activity supported by Noxo1 and Noxa1. Although Nox3 complexed with p22(phox) constitutively produce superoxide, the production can be enhanced by supportive proteins. Here we compare the roles of Rac in these p22(phox)-dependent oxidases using the organizer and activator in different combinations. Expression of constitutively active Rac1(Q61L) is essential for activation of the Nox2- or Nox1-based oxidase containing the organizer p47(phox) and either p67(phox) or Noxa1. When these oxidases use Noxo1 as an organizer instead of p47(phox), they produce a small but significant amount of superoxide without expression of Rac1(Q61L), although the production is enhanced by Rac1(Q61L). Thus p47(phox) is likely related to strict dependence on Rac. The Nox3-based oxidase has a similar tendency in the change of the dependence: Rac plays a positive role in Nox3 activation in the presence of p47(phox) and either p67(phox) or Noxa1, whereas Rac fails to upregulate Nox3 activity when p47(phox) is replaced with Noxo1. We also demonstrate that, in the Nox3-based oxidase containing solely p67(phox) as supportive protein, expression of Rac1(Q61L) enhances not only superoxide production but also membrane translocation of p67(phox). Since the enhancements are not observed with a mutant p67(phox) defective in binding to Rac, this GTPase appear to directly recruit p67(phox) to the membrane.
Output: Which NADPH oxidase family member requires interaction with NOXO1 for function?
During 1970 and 1971, I discovered that a devastating disease of potato plants is not caused by a virus, as had been assumed, but by a new type of subviral pathogen, the viroid. Viroids are so small--one fiftieth of the size of the smallest viruses--that many scientists initially doubted their existence. We now know that viroids cause many damaging diseases of crop plants. Fortunately, new methods that are based on the unique properties of viroids now promise effective control.
Output: Which are the smallest known subviral pathogens of plants?
It was 1:30 a.m. Monday at London's Savoy Hotel and, with autograph books and cameras, a group of brighteyed tennis fans of all ages were waiting for just a glimpse of Maria Sharapova . The 17-year-old girl defeated champion Serena Williams 6-1 6-4 in the Wimbledon final on Saturday in London to become the first Russian to win a single title at the championships. A silver lining to a depressing, rain-hit Wimbledon, she has raised heated passion. Nobody was complaining, though, for the 1.83-metre Sharapova has created a welcome wave of interest in tennis, something missing in recent years. Not even Anna Kournikova evoked such passion when she broke on to the scene. To look good on court is one thing, but Sharapova can actually play the game too. Extremely well. She proved it over 13 days at the world's most prestigious tournament. Playing tennis of the highest quality throughout, the Russian's triumph not only lifted the tournament from fits of rain-induced depression but also salvaged(;) the season for the woman's tour. Sharapova was given no easy ride in the tournament, having to beat 1999 champion Lindsay Davenport in the semifinals and twice-champion Serena Williams for the title. Neither caused her much concern. "I don't remember too much about the final," Sharapova giggled. "I was in my own place." She will find it increasingly hard to find any place to call her own from now on after advertisers identified her as the most marketable woman in sport. In Russia she is sensational news. She headlined the news bulletins and was telephoned by former Russian President Boris Yeltsin after her triumph. Sharapova will return to her adoptive Florida home knowing life will never be the same again. But the girl who arrived in the US aged seven with her father and just US$700 is determined not to let fame and riches detract from her number one love, tennis. "I know things will start coming up and that many more things will want to get involved, but I want to keep my head cool and play tennis," she said.
Output: Who has won the most times in Wimbledon?
Asset Acceptance Capital Corp. is publicly traded (NASDAQ: AACC).
Output: Which exchange is Asset Acceptance listed with?
Facioscapulohumeral Disease (FSHD) is a dominantly inherited progressive myopathy associated with aberrant production of the transcription factor, Double Homeobox Protein 4 (DUX4). The expression of DUX4 depends on an open chromatin conformation of the D4Z4 macrosatellite array and a specific haplotype on chromosome 4. Even when these requirements are met, DUX4 transcripts and protein are only detectable in a subset of cells indicating that additional constraints govern DUX4 production. Since the direction of transcription, along with the production of non-coding antisense transcripts is an important regulatory feature of other macrosatellite repeats, we developed constructs that contain the non-coding region of a single D4Z4 unit flanked by genes that report transcriptional activity in the sense and antisense directions. We found that D4Z4 contains two promoters that initiate sense and antisense transcription within the array, and that antisense transcription predominates. Transcriptional start sites for the antisense transcripts, as well as D4Z4 regions that regulate the balance of sense and antisense transcripts were identified. We show that the choice of transcriptional direction is reversible but not mutually exclusive, since sense and antisense reporter activity was often present in the same cell and simultaneously upregulated during myotube formation. Similarly, levels of endogenous sense and antisense D4Z4 transcripts were upregulated in FSHD myotubes. These studies offer insight into the autonomous distribution of muscle weakness that is characteristic of FSHD.
Output: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
The organic cation transporter 3 (OCT3) is a widely expressed transporter for endogenous and exogenous organic cations. Of particular interest is OCT3 expression and function in the brain, where it plays a role in serotonin clearance and influences mood and behavior. Protein kinase signaling mediates rapid modulation of cerebral processes, but little is known about acute regulation of OCT3 by protein kinases. Therefore, we cloned mouse OCT3 (mOCT3) and generated a human embryonic kidney cell line stably expressing the transporter to study transport characteristics, acute regulation by protein kinases, and interaction with psychotropic drugs. Uptake measurement was performed using the fluorescent cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+), 1M) as a substrate. The translational value of these findings was determined by comparing results obtained with cloned mouse and human OCT3. mOCT3-mediated transport is membrane potential dependent and pH independent. ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam. The half maximal inhibitory concentrations of mOCT3 and hOCT3 for TPA(+), serotonin, diazepam, and ketamine are significantly different. Diazepam is a non-transported inhibitor. Furthermore, the activities of mOCT3 and hOCT3 are acutely regulated by the p56 (lck) tyrosine kinase by decreasing their V max. Studies with freshly isolated renal proximal tubules from mOCT1/2(-/-) mice, in which mOCT3 is the only OCT present, confirmed this regulation pathway. Only the activity of hOCT3 is regulated by calmodulin. These findings suggest that even though many transport properties of mOCT3 and hOCT3 are similar, there are also species-specific aspects of OCT3 function.
Output: How is OCT3 associated with serotonin?
There are 27,908 households, of which 31.5% have children under the age of 18 living with them, 48.9% were married couples living together, 15.4% had a female householder with no husband present, and 32.3% were non-families. 28.4% of all households are made up of individuals, and 10.6% had someone living alone who was 65 years of age or older. The average household size was 2.39, and the average family size was 2.94. 70% of women with school-age children work.
Output: which household was fourth most common?
Imagine a huge bar magnet passing through Earths axis, as in the Figure 1.1. This is a good representation of Earth as a magnet. Like a bar magnet, Earth has north and south magnetic poles. A magnetic pole is the north or south end of a magnet, where the magnet exerts the most force. Although the needle of a compass always points north, it doesnt point to Earths north geographic pole. Find the north geographic pole in the Figure 1.2. As you can see, it is located at 90 north latitude. Where does a compass Q: The north end of a compass needle points toward Earths north magnetic pole. The like poles of two magnets repel each other, and the opposite poles attract. So why doesnt the north end of a compass needle point to Earths south magnetic pole instead? A: The answer may surprise you. The compass needle actually does point to the south pole of magnet Earth. However, it is called the north magnetic pole because it is close to the north geographic pole. This naming convention was adopted a long time ago to avoid confusion. Like all magnets, Earth has a magnetic field. Earths magnetic field is called the magnetosphere. You can see a model of the magnetosphere in the Figure 1.3. It is a huge region that extends outward from Earth in all directions. Earth exerts magnetic force over the entire field, but the force is strongest at the poles, where lines of force converge. Click image to the left or use the URL below. URL:
Output: which shape of magnet does magnet earth resemble?
What time of day can you think most quickly? Are you a morning person? Or does it take you a few hours to get your brain going? A lot of recent research suggests that we should pay attention to our body clock. It can tell us what time of day we can perform best at. Many people work best later in the morning. This is because the body's temperature takes time to rise through the day. Taking a warm shower when you wake up can help your body's temperature rise quickly. But everyone's body clock is different and some are special. Morning people will get up early and work better early in the day. Evening people will work later but work better towards the end of the day. Research shows that we're better at some activities at certain times of the day. Physical performance is at its best between 3 pm and 6 pm, so it's better to exercise later in the day. Between noon and 4 pm, people begin to pay less attention. This is because we think less quickly after a big meal. Research also shows we become sleepy around 2 pm. This is why people in Spain take a short sleep in early afternoon. Finally, it is best to eat when we're active. This allows our body to burn calories better and stops our blood sugar levels from getting too high.
Output: What is the best time for physical performance?
Anticoagulation therapy is indicated for management of various clinical conditions to prevent adverse events and introduction of direct oral anticoagulants (DOACs) has ushered in a new era in anticoagulation therapy. Major advantages of DOACS include fewer drug interactions and that they do not need periodic monitoring. Several patients who were not on anticoagulation before due to older age, polypharmacy/drug interaction concerns, and logistics of periodic monitoring are now on anticoagulation with DOACs. Despite their many advantages, a challenge while prescribing DOACs is very limited availability of specific reversal agents and lack of understanding or guidance about the treatment strategy in case of major life threatening bleeding or need for urgent surgery. So far only one reversal agent has been approved by the Food and Drug Administration (FDA), idarucizumab for one of the DOACs i.e., dabigatran. Several other reversal agents are under final phases of development such as andexanet alfa and PER977 (ciraparantag) and will help in developing specific strategies for reversal of these agents. In this article, we review current strategies to manage bleeding with DOACs and provide guidance to clinicians of inhibiting LF activity in vitro and in cells, as well as in animal models of anthrax infection.
Output: Which drug can be reversed with idarucizumab?
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Output: What number can you call if you need some advice for skin care?
The Duel After the Masquerade is a painting by the French artist Jean-Leon Gerome, currently part of The Walters Art Museum collection.
Output: What is the name of the place where The Duel After the Masquerade can be found?
The 12th Congress of the Russian Communist Party (Bolsheviks) was held during 17--25 April 1923 in Moscow.
Output: On what date did 12th Congress of the Russian Communist Party (Bolsheviks) end?