niryuu/sni-each-converted huggingface dataset:
When cDNA containing proteins enriched in the bovine cerebellar cortex were cloned, a clone which seemed to encode a selenoprotein P-like protein was isolated. The coding nucleotide sequence of its cDNA insert displayed high homology to rat and human selenoprotein P cDNA but contained 12 rather than 10 TGAs (12 rather than 10 selenocysteines in deduced amino acids), a tandem repeat of one CACTCC (His-Ser) and seven CATCCCs (His-Pro), and a 3' untranslated region approximately 890 bases shorter than that of rat liver selenoprotein P. RT-PCR using a set of primers flanking to the repeat displayed the existence of mRNA without the repeat. The tandem repeat and its adjacent region consisted of a similar motif of CAC/TCC/AC/T. Thus, these proteins included a (His-Pro) rich domain with a slightly negative free energy change irrespective of having the tandem repeat or not. Such His-Pro repeats reportedly exist in the segmentation gene paired or homeobox protein Om(1D) of Drosophila. Moreover, both this selenoprotein P-like protein mRNA and selenoprotein P mRNA were expressed in all the areas of the brain but most prominently in the cerebellar cortex, hippocampus, and olfactory bulb. These findings suggest the possibility that these selenoproteins are major selenium carriers in the brain and play a role in the morphological response of nerve or glial cells.
Output: Which is the human selenoprotein that contains several Se-Cys residues?
The male reproductive organs include the penis, testes, and epididymis ( Figure 1.1). The figure also shows other parts of the male reproductive system. The penis is a cylinder-shaped organ. It contains the urethra. The urethra is a tube that carries urine out of the body. The urethra also carries sperm out of the body. This drawing shows the organs of the male reproductive system. It shows the organs from the side. Find each organ in the drawing as you read about it in the text. The two testes (singular, testis) are egg-shaped organs. They produce sperm and secrete testosterone. The testes are found inside of the scrotum. The scrotum is a sac that hangs down outside the body. The scrotum also contains the epididymis. The testes, being in the scrotum outside the body, allow the temperature of the sperm to be maintained at a few degrees lower than body temperature. This is necessary for the stability of these reproductive cells. The epididymis is a tube that is about six meters (20 feet) long in adults. It is tightly coiled, so it fits inside the scrotum. It rests on top of the testes. The epididymis is where sperm grow larger and mature. The epididymis also stores sperm until they leave the body. Other parts of the male reproductive system include the vas deferens and the prostate gland. Both of these structures are pictured below ( Figure 1.1). The vas deferens is a tube that carries sperm from the epididymis to the urethra. The prostate gland secretes a fluid that mixes with sperm to help form semen. The prostate gland is located beneath the bladder. Semen is a "milky" liquid that carries sperm through the urethra and out of the body. In addition to sperm cells, semen contains sugars (fructose) which provide energy to the sperm cells, and enzymes and other substances which help the sperm survive.
Output: what is the organ where sperm cells mature?
Wars of America is a ''colossal'' bronze sculpture by Gutzon Borglum containing ''forty-two humans and two horses'', located in Military Park, Newark, Essex County, New Jersey, United States.
Output: What material was used for Wars of America?
While performing on her Intimate and Live concert tour in Australia, Minogue confirmed that she would release ''Cowboy Style'' as the fourth single in Australia and New Zealand by Mushroom Records.
Output: Which was the record label for Cowboy Style?
Eukaryotic cells have many specific functions, so it can be said that a cell is like a factory. A factory has many machines and people, and each has a specific role. Just like a factory, the cell is made up of many different parts. Each part has a special role. The different parts of the cell are called organelles, which means "small organs." All organelles are found in eukaryotic cells. Prokaryotic cells are "simpler" than eukaryotic cells. Though prokaryotic cells still have many functions, they are not as specialized as eukaryotic cells, lacking membrane-bound organelles. Thus, most organelles are not found in prokaryotic cells. Below are the main organelles found in eukaryotic cells ( Figure 1.1): 1. The nucleus of a cell is like a safe containing the factorys trade secrets. The nucleus contains the genetic material (DNA), the information needed to build thousands of proteins. 2. The mitochondria are the powerhouses of the cell. Mitochondria are the organelles where cellular energy is produced, providing the energy needed to power chemical reactions. This process, known as cellular respiration, produces energy is in the form of ATP (adenosine triphosphate). Cells that use a lot of energy may have thousands of mitochondria. 3. Vesicles are small membrane bound sacs that transport materials around the cell and to the cell membrane. 4. The vacuoles are like storage centers. Plant cells have larger vacuoles than animal cells. Plants store water and nutrients in their large central vacuoles. 5. Lysosomes are like the recycling trucks that carry waste away from the factory. Lysosomes have digestive enzymes that break down old molecules into parts that can be recycled. 6. In both eukaryotes and prokaryotes, ribosomes are the non-membrane bound organelles where proteins are made. Ribosomes are like the machines in the factory that produce the factorys main product. Proteins are the main product of the cell. 7. Some ribosomes can be found on folded membranes called the endoplasmic reticulum (ER), others float freely in the cytoplasm. If the ER is covered with ribosomes, it looks bumpy like sandpaper, and is called the rough endoplasmic reticulum. If the ER does not contain ribosomes, it is smooth and called the smooth endoplasmic reticulum. Many proteins are made on the ribosomes on the rough ER. These proteins immedi- ately enter the ER, where they are modified, packaged into vesicles and sent to the Golgi apparatus. Lipids are made in the smooth ER. 8. The Golgi apparatus works like a mail room. The Golgi apparatus receives proteins from the rough ER and puts "shipping addresses" on them. The Golgi then packages the proteins into vesicles and sends them to the right place in the cell or to the cell membrane. Some of these proteins are secreted from the cell (they exit the cell); others are placed into the cell membrane. Also, the cytoskeleton gives the cell its shape, and the flagella helps the cell to move. Prokaryotic cells may also have flagella.
Output: which organelle modifies and packages proteins for transport?
In A Game of Thrones (1996), Ned Stark is the virtuous and honorable patriarch of House Stark and the father of six children.
Output: What was the noble family that Ned Stark was from?
Dreams in a Drawer (Italian: I sogni nel cassetto) is a 1957 Italian romantic drama film written and directed by Renato Castellani and starring Lea Massari.
Output: The main director of Dreams in a Drawer was who?
Motherhood may make women smarter and may help prevent dementia in old age by bathing the brain in protective hormones , U.S.researchers reported on Thursday. Tests on rats show that those who raise two or more litters of pups do considerably better in tests of memory and skills than rats who have no babies, and their brains show changes that suggest they may be protected against diseases such as Alzheimer's .University of Richmond psychology professor Craig Kinsley believes his findings will translate into humans."Our research shows that the hormones of pregnancy are protecting the brain, including estrogen , which we know has many neuroprotective effects," Kinsley said. "It's rat data but humans are mammals just like these animals are mammals," he added in a telephone interview."They go through pregnancy and hormonal changes." Kinsley said he hoped public health officials and researchers will look to see if having had children protects a woman from Alzheimer's and other forms of age-related brain decline. "When people think about pregnancy, they think about what happens to babies and the mother from the neck down," said Kinsley, who presented his findings to the annual meeting of the Society of Neuroscience in Orlando, Florida. "They do not realize that hormones are washing on the brain.If you look at female animals that have never gone through pregnancy, they act differently toward young.But if she goes through pregnancy, she will sacrifice her life for her infant--that is a great change in her behavior that showed in genetic alterations to the brain."
Output: What can protect the brain of a woman according to the passage?
Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD ("Kings of Destruction") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a "school donation." While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a "car accident" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers.
Output: Shale fought in what war?
In May 1918, a conservative-monarchist Senate was formed by J. K. Paasikivi, and the Senate asked the German troops to remain in Finland. 3 March 1918 Treaty of Brest-Litovsk and 7 March German-Finnish agreements bound White Finland to the German Empire's sphere of influence. General Mannerheim resigned his post on 25 May after disagreements with the Senate about German hegemony over Finland, and about his planned attack on Petrograd to repulse the Bolsheviks and capture Russian Karelia. The Germans opposed these plans due to their peace treaties with Lenin. The Civil War weakened the Finnish Parliament; it became a Rump Parliament that included only three socialist representatives. On 9 October 1918, under pressure from Germany, the Senate and Parliament elected a German prince, Friedrich Karl, the brother-in-law of German Emperor William II, to become the King of Finland. The German leadership was able to utilise the breakdown of Russia for the geopolitical benefit of the German Empire in Fennoscandia also. The Civil War and the aftermath diminished independence of Finland, compared to the status it had held at the turn of the year 1917-1918. The economic condition of Finland deteriorated drastically from 1918; recovery to pre-conflict levels was achieved only in 1925. The most acute crisis was in food supply, already deficient in 1917, though large-scale starvation had been avoided that year. The Civil War caused marked starvation in southern Finland. Late in 1918, Finnish politician Rudolf Holsti appealed for relief to Herbert Hoover, the American chairman of the Committee for Relief in Belgium. Hoover arranged for the delivery of food shipments and persuaded the Allies to relax their blockade of the Baltic Sea, which had obstructed food supplies to Finland, and to allow food into the country.
Output: Which happened first, the formation of a Senate, or electing a German prince?
The aim of this study was to assess to what extent patients with meticillin-resistant Staphylococcus aureus (MRSA) at respiratory sites shed viable MRSA into the air of hospital rooms. We also evaluated whether the distance from the patient could influence the level of contamination. Air sampling was performed directly onto MRSA-selective agar in 24 hospital rooms containing patients with MRSA colonization or infection of the respiratory tract. Samplings were performed in duplicate at 0.5, 1 and 2-3 m from the patients' heads. Clinical and environmental isolates were compared using antimicrobial resistance patterns and pulsed-field gel electrophoresis. MRSA strains were isolated from 21 out of 24 rooms, in quantities varying from between 1 and 78 cfu/m3. In each of the 21 rooms, at least one of the environmental isolates was identical to a clinical isolate from the patient in that room. There was no significant difference in MRSA counts between the distance from the patient's head and the sampler. This study demonstrates that most patients with MRSA infection or colonisation of the respiratory tract shed viable MRSA into the air of their room. The results emphasise the need to study MRSA in air in more detail in order to improve infection control recommendations.
Output: What is MRSA?
Catherine Antonovna of Brunswick-Luneburg (1741--1807), daughter of Duke Anthony Ulrich of Brunswick and Grand Duchess Anna Leopoldovna of Russia.
Output: Who was Catherine Antonovna of Brunswick's mother?
The story is not linked to the first part of the series. Instead, it focuses on a fictional explanation for the Ryanggang explosion in 2004, in which an unexplained mushroom cloud occurred in North Korea. After reconnaissance satellites detect a large, three-stage Topol intercontinental ballistic missile carrying a nuclear weapon in North Korea, which can strike anywhere in the continental United States, a fictional United States President Adair T. Manning (Peter Coyote) orders a team of U.S. Navy SEALs to destroy the missile and the launch site. The team is led by Lieutenant Robert James (Nicholas Gonzalez). The Pentagon aborts the mission after it receives new information, but by the time the abort order is sent, two SEALs have already parachuted into North Korean territory. James stops the third SEAL from deploying, accidentally knocking the man's helmet against the status indicator mounted near the door. The lieutenant steps onto the makeshift ramp to peer outside, returning to the doorway to inform the rest of men of the abort. The high-speed winds from outside rip the indicator loose and send it flying into the lieutenant's face. Stumbling backwards, James loses his balance and is sucked out of the plane. Callaghan disobeys orders to stand fast, strikes his commanding officer, and follows the first three, taking a radio with him. When North Korean forces led by Commander Hwang (Joseph Steven Yang) find the SEALs, two of the Navy SEALs are killed in a gun battle, and James and Callaghan are captured and tortured by Hwang and his men. After South Korean special forces rescue James and Callaghan, President Manning and the South Korean government send the SEALs and South Korean special forces to destroy the missile site. But after losing radio contact with the SEALs, the President and his top advisers believe that they have been captured again. Under pressure from his military advisor, General Norman Vance (Bruce McGill), the President decides to send B-2 stealth bombers to destroy the site, which would start a full-scale war against North Korea. The SEALs and the South Korean special forces are almost recaptured by Hwang, but he is shot by a defecting officer. James and the South Koreans destroy the missile silo with a bomb before the bombers reach the missile site, which averts the bombing and prevents a full-scale war. A tribunal convicts Callaghan of striking an officer (1 year) and disobeying an officer (10 years). Due to the "black op" nature of the mission, the transcript of the hearing is deemed classified and the charges are expunged from his record, leaving him free to return to his family. Meanwhile, James meets the president in a classified meeting, bringing his mentor Master Chief Scott Boytano (Keith David) as witness to James' receiving of an award. The film closes with Boytano telling James he wasn't red flagged because Boytano had never seen anyone who desired so badly as James did to be a SEAL. During the credits there is a news report on the Ryanggang explosion.
Output: Who destroys the missile silo?
Brepols was once one of the largest printing companies of the world and one of the main employers in Turnhout (Belgium).
Output: In what city or state did the formation of Brepols occur?
Electronic book publishing has many of the same risks and opportunities as electronic music publishing. By delivering text direct to the user's computer screen, the e-book could cut down costs, and allow creators to deal directly with their audience, bypassing traditional publishers and readers. But it also raises the possibility of mass piracy . Phil Rance, founder and managing director of Online Originals, a London-based e-book publisher, sums it up. "No one wants Napster to happen to books." Indeed, the most popular MP3 have put the frighteners on an industry that generally operates some way behind the "bleeding edge". The Mata Group, a leading US-based market researcher, says publishers are far too concerned about protecting their rights, "We believe all the recent legal control over Napster is like putting a finger in a river that is already overflowing. Publishers need to deal with reality and come up with new ways to develop wide electronic distribution , asking the question: 'How can we use the certainty of wide distribution to our advantage?'" At the moment, most publishers would like to limit the use of e-books to the person who bought them, or to the computer used to download them. If that can be done, e-books become just an extra income stream in a publishing industry that would continue to operate the way it does today, according to Terry Robinson, business manager for Adobe's e-paper group. "If you've cracked digital rights aspect, you've cracked the market," he says. Robert Nichols, Books Director at BOL agrees, "Rights management is absolutely important. Publishers just say that 'until copyright is secure, we're not going to talk'."
Output: What do publishers care most about e-books?
4942 Munroe (1987 DU6) is a main-belt minor planet discovered by Henri Debehogne at La Silla Observatory in Chile on February 24, 1987.
Output: The 4942 Munroe was discovered by whom?
With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.
Output: What does mTOR stands for?
In this life, what did you miss? The wife asked the husband when she was 25. Despondently, the husband replied: 'I missed a new job opportunity.' When she was 35, the husband angrily told her that he had just missed the bus. At 45, the husband sadly said: 'I missed the opportunity seeing my closed relative before his last breath.' At 55, the husband said disappointingly: 'I missed a good chance to retire.' At 65, the husband hurriedly replied: 'I missed a dental appointment.' At 75, the wife did not ask the husband anymore, the husband was kneeling in front of the very sick wife. Remembering the question the wife used to ask him, this time he asked the wife the same question. The wife, with a smile and peaceful look, replied: 'In this life, I did not miss having you!' The husband was full of tears. He always thought that they could be together forever. He was always busy with work and trifles. So much so he had never been thoughtful to his wife. The husband hugged the wife tightly and said: 'Over 50 years, how I had allowed myself to miss your deep love for me.' In the busy city life, there are many people who are always busy with work. These people revolve their lives around their jobs, these people sacrifice all their times and health to meet the social expectations. They are unwilling to spend times on health care. They miss the opportunity to be with their children in their growing up. They neglect the loved ones who care for them, and also their health. Nobody knows what is going to happen one year from now. Life is not _ , so always live in the now. Express your gratitude to your loved ones in words. Show your care with actions. Treat everyday as the last episode of life. In this way, when you are gone, you loved ones would have nothing to feel sorry about.
Output: What is the passage mainly about?
Vodafone Egypt provides its services for both individuals and enterprises in Egypt focusing on telecommunication services from Voice to Data and Internet services.
Output: Which industry is Vodafone Egypt associated with?
The Broncos' defense limited the Chiefs to 279 total yards 133 of which went to tight end Travis Kelce. However, the Broncos were unable to overcome five turnovers, including three interceptions by quarterback Trevor Siemian, as well as a fumble by running back Jamaal Charles that resulted in a Chiefs' touchdown. After trailing 20-3 early in the third quarter, the Broncos narrowed the Chiefs' lead to 20-13, following a 6-yard touchdown by running back Devontae Booker. However, three fourth-quarter field goals by Chiefs' placekicker Harrison Butker the latter two of which occurred after a Broncos' turnover on downs and Siemian's third interception of the game, increased the Chiefs' lead to 29-13. With 4:41 remaining in the game, the Broncos' attempted a rally, with Siemian connecting on an 11-yard touchdown pass to tight end A. J. Derby at the two-minute warning. However, the two-point conversion attempt was unsuccessful, which would have brought the Broncos' to within a one-score deficit, ending the Broncos' rally attempt. This was Jamaal Charles' first game against the Chiefs, for whom he played the first nine seasons of his career.
Output: Which player scored the final touchdown of the game?
Pirates of Treasure Island is a 2006 American comedy-drama film produced by The Asylum, loosely adaptated from Robert Louis Stevenson's novel Treasure Island.
Output: What studio produced Pirates of Treasure Island?
In the north of the region is the Sailughem Mountains, also known as Kolyvan Altai, which stretch northeast from 49 N and 86 E towards the western extremity of the Sayan Mountains in 51 60 N and 89 E. Their mean elevation is 1,500 to 1,750 m. The snow-line runs at 2,000 m on the northern side and at 2,400 m on the southern, and above it the rugged peaks tower some 1,000 m higher. Mountain passes across the range are few and difficult, the chief being the Ulan-daban at 2,827 m (2,879 m according to Kozlov), and the Chapchan-daban, at 3,217 m, in the south and north respectively. On the east and southeast this range is flanked by the great plateau of Mongolia, the transition being effected gradually by means of several minor plateaus, such as Ukok plateau (2,380 m) with Pazyryk Valley, Chuya (1,830 m), Kendykty (2,500 m), Kak plateau (2,520 m), (2,590 m), and (2,410 m).
Output: Which plateau has the lowest elevation of Ukok, Chuya, and Kak?
The French Revolution broke out in 1789. At the time France was in a crisis. The government was badly run and people's lives were miserable. King Louis XIV tried to control the national parliament and raise more taxes. But his effort failed. He ordered his troops to Versailles. The people thought that Louis intended to put down the Revolution by force. On July 14, 1789, they stormed and took the Bastille, where political prisoners were kept. Ever since that day, July 14 has been the French National Day. Louis tried to flee the country in 1792, to get support from Austria and Prussia. However, he was caught and put in prison. In September 1792, the monarchy was abolished _ . In the same year, Louis was executed. A few months later his wife, Marie also had her head cut off. The Revolution of France had frightened the other kings of Europe. Armies from Austria and Prussia began to march against France. The French raised republican armies to defend the nation. The Revolution went through a period of terror. Thousands of people lost their lives. In the end, power passed to Napoleon Bonaparte.
Output: What's this passage about?
Fluorescence in situ hybridization (FISH) technique has been successfully used to detect the BCR-ABL gene fusion in chronic myeloid leukemia (CML) with the classic form of the Philadelphia chromosome (Ph). We applied FISH to study three CML patients showing variant Ph chromosome (either complex or simple type). The results demonstrate that the use of a yeast artificial chromosome (YAC)-derived probe (D107F9) and a cosmid probe (cos-abl 8), specific for BCR and ABL genes respectively, allows also the detection of the BCR-ABL fusion in CML patients with variant Ph.
Output: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
In 1908 the U.S. Supreme Court decided Loewe v. Lawlor . In 1902 the Hatters' Union instituted a nationwide boycott of the hats made by a nonunion company in Connecticut. Owner Dietrich Loewe brought suit against the union for unlawful combinations to restrain trade in violation of the Sherman Antitrust Act. The Court ruled that the union was subject to an injunction and liable for the payment of triple damages. In 1915 Justice Oliver Wendell Holmes, speaking for the Court, again decided in favor of Loewe, upholding a lower federal court ruling ordering the union to pay damages of $252,130. . This was not a typical case in which a few union leaders were punished with short terms in jail; specifically, the life savings of several hundreds of the members were attached. The lower court ruling established a major precedent, and became a serious issue for the unions. The Clayton Act of 1914 presumably exempted unions from the antitrust prohibition and established for the first time the Congressional principle that "the labor of a human being is not a commodity or article of commerce". However, judicial interpretation so weakened it that prosecutions of labor under the antitrust acts continued until the enactment of the Norris-La Guardia Act in 1932.
Output: Which Act happened last, the Clayton act, or the Norris-La Guardia Act?
Community-associated methicillin-resistant Staphylococcus aureus-(CA-MRSA) strains have emerged in Argentina. We investigated the clinical and molecular evolution of community-onset MRSA infections (CO-MRSA) in children of Cordoba, Argentina, 2005-2008. Additionally, data from 2007 were compared with the epidemiology of these infections in other regions of the country. Two datasets were used: i) lab-based prospective surveillance of CA-MRSA isolates from 3 Cordoba pediatric hospitals-(CBAH1-H3) in 2007-2008 (compared to previously published data of 2005) and ii) a sampling of CO-MRSA from a study involving both, healthcare-associated community-onset-(HACO) infections in children with risk-factors for healthcare-associated infections-(HRFs), and CA-MRSA infections in patients without HRFs detected in multiple centers of Argentina in 2007. Molecular typing was performed on the CA-MRSA-(n: 99) isolates from the CBAH1-H3-dataset and on the HACO-MRSA-(n: 51) and CA-MRSA-(n: 213) isolates from other regions. Between 2005-2008, the annual proportion of CA-MRSA/CA-S. aureus in Cordoba hospitals increased from 25% to 49%, P<0.01. Total CA-MRSA infections increased 3.6 fold-(5.1 to 18.6 cases/100,000 annual-visits, P<0.0001), associated with an important increase of invasive CA-MRSA infections-(8.5 fold). In all regions analyzed, a single genotype prevailed in both CA-MRSA (82%) and HACO-MRSA(57%), which showed pulsed-field-gel electrophoresis-(PFGE)-type-"I", sequence-type-5-(ST5), SCCmec-type-IVa, spa-t311, and was positive for PVL. The second clone, pulsotype-N/ST30/CC30/SCCmecIVc/t019/PVL(+), accounted for 11.5% of total CA-MRSA infections. Importantly, the first 4 isolates of Argentina belonging to South American-USA300 clone-(USA300/ST8/CC8/SCCmecIVc/t008/PVL(+)/ACME(-)) were detected. We also demonstrated that a HA-MRSA clone-(pulsotype-C/ST100/CC5) caused 2% and 10% of CA-MRSA and HACO-MRSA infections respectively and was associated with a SCCmec type closely related to SCCmecIV(2B&5). The dissemination of epidemic MRSA clone, ST5-IV-PVL(+) was the main cause of increasing staphylococcal community-onset infections in Argentinean children (2003-2008), conversely to other countries. The predominance of this clone, which has capacity to express the h-VISA phenotype, in healthcare-associated community-onset cases suggests that it has infiltrated into hospital-settings.
Output: What is MRSA?
John Albert Taylor (June 6, 1959 -- January 26, 1996) was an American who was convicted of burglary and carrying a concealed weapon in the state of Florida, and sexual assault and murder in the state of Utah.
Output: For what crime was John Albert Taylor prosecuted?
Zeke Bella died on November 17, 2013, from complications due to a stroke, and the injuries received from a fall it induced;
Output: What was Zeke Bella's cause of death?
Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are present in lung adenocarcinomas that respond to the EGFR inhibitors gefitinib and erlotinib. Two types of mutations account for approximately 90% of mutated cases: short in-frame deletions in exon 19 and a specific point mutation in exon 21 at codon 858 (L858R). Screening for these mutations has been based mainly on direct sequencing. We report here the development and validation of polymerase chain reaction-based assays for these two predominant types of EGFR mutations. The assay for exon 19 mutations is based on length analysis of fluorescently labeled polymerase chain reaction products, and the assay for the exon 21 L858R mutation is based on a new Sau96I restriction site created by this mutation. Using serial dilutions of DNAs from lung cancer cell lines harboring either exon 19 or 21 mutations, we detected these mutations in the presence of up to approximately 90% normal DNA. In a test set of 39 lung cancer samples, direct sequencing detected mutations in 25 cases whereas our assays were positive in 29 cases, including 4 cases in which mutations were not apparent by sequencing. These assays offer higher sensitivity and ease of scoring and eliminate the need for sequencing, providing a robust and accessible approach to the rapid identification of most lung cancer patients likely to respond to EGFR inhibitors.
Output: Mutations in which gene determine response to both erlotinib and gefitinib?
Silverjet was a British all-business class airline headquartered at London Luton Airport, Luton, Bedfordshire, England, that, prior to the suspension of operations on 30 May 2008, operated services to Newark Liberty International Airport and Dubai International Airport.
Output: What is the name of the airport associated with Silverjet?
Interleukin-1 (IL-1) is a proinflammatory cytokine that is implicated in many autoinflammatory disorders, but is also important in defense against pathogens. Thus, there is a need to safely and effectively modulate IL-1 activity to reduce pathology while maintaining function. Gevokizumab is a potent anti-IL-1 antibody being developed as a treatment for diseases in which IL-1 has been associated with pathogenesis. Previous data indicated that gevokizumab negatively modulates IL-1 signaling through an allosteric mechanism. Because IL-1 signaling is a complex, dynamic process involving multiple components, it is important to understand the kinetics of IL-1 signaling and the impact of gevokizumab on this process. In the present study, we measured the impact of gevokizumab on the IL-1 system using Schild analysis and surface plasmon resonance studies, both of which demonstrated that gevokizumab decreases the binding affinity of IL-1 for the IL-1 receptor type I (IL-1RI) signaling receptor, but not the IL-1 counter-regulatory decoy receptor (IL-1 receptor type II). Gevokizumab inhibits both the binding of IL-1 to IL-1RI and the subsequent recruitment of IL-1 accessory protein primarily by reducing the association rates of these interactions. Based on this information and recently published structural data, we propose that gevokizumab decreases the association rate for binding of IL-1 to its receptor by altering the electrostatic surface potential of IL-1, thus reducing the contribution of electrostatic steering to the rapid association rate. These data indicate, therefore, that gevokizumab is a unique inhibitor of IL-1 signaling that may offer an alternative to current therapies for IL-1-associated autoinflammatory diseases.
Output: Which molecule is targeted by the drug Gevokizumab?
Treatment of CLL patients with conventional cytotoxic agents is often combined with significant toxicity that prevents broad application especially in elderly patients. In addition, relapse frequently occurs after application of conventional chemotherapy in CLL. Recently several new chemo-free treatment options have been introduced within clinical trials. Among them are monoclonal antibodies, most of them targeting the CD20 molecule: besides the licensed drugs rituximab and ofatumumab obinutuzumab, although in combination with chemotherapy, has recently shown high clinical efficacy in front-line treatment of elderly patients with CLL. Lenalidomide as monotherapy has demonstrated clinical efficacy in patients with relapsed disease and first data within clinical trials have been generated in the front-line setting. A promising class of novel agents has been designed to block aberrant signaling from the B-cell receptor. Ibrutinib acts by inhibiting the Bruton's tyrosine kinase (BTK) while idelalisib represents a first-in-class specific inhibitor of the phosphoinositol-3 kinase (PI3K) delta isoform. Another class of drugs with potential impact for chemo-free treatment strategies in CLL are the BH3-mimetic inhibitors of the Bcl-2 family of pro-survival proteins. Other interesting candidate drugs that are currently explored for CLL patients include small modular immunopharmaceutical (SMIP) proteins (e. g. TRU-016), CDK inhibitors (e. g. dinaciclib), HDAC inhibitors and others. Given all these novel agents and targets, chemo-free or at least chemo-reduced concepts may become reality in the near future for our patients suffering from CLL.
Output: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?
at the Georgia Dome, Atlanta, Georgia Trying to end a three-game skid, the Falcons returned home for an NFC South rematch with the New Orleans Saints. From the get-go, the Falcons trailed as in the first quarter, QB Drew Brees completed a 76-yard TD pass to WR Devery Henderson, while RB Deuce McAllister got a 1-yard TD run. Atlanta would respond with kicker Morten Andersen kicking a 22-yard field goal. In the second quarter, Andersen gave the Falcons a 30-yard field goal, yet New Orleans continued dominating with Brees completing an incredible 48-yard TD pass to WR Terrance Copper on the very last offensive play of the half. In the third quarter, RB Warrick Dunn gave Atlanta some room to operate, as he a 1-yard TD run for the only score of the half. However, in the fourth quarter, the Saints wrapped up the game with kicker John Carney getting a 25-yard field goal, while McAllister got a 9-yard TD run. After the game, as QB Michael Vick was leaving the field, he flicked off an insulting fan with both hands. He was fined $10,000 from the NFL and had to donate another $10,000 to charity. With their fourth-straight loss, the Falcons fell to 5-6.
Output: Which team allowed the least points in the first quarter?
32 Ophiuchi (32 Oph) is a star in the constellation Hercules.
Output: What constellation is 32 Ophiuchi part of?
Estadio Alberto Gallardo is a football stadium in the San Martin de Porres District of Lima, Peru, current home ground of the football club Sporting Cristal.
Output: What team uses Estadio Alberto Gallardo?
As we all know , the language is a very important tool for people to communicate with each other. In most of the languages , people usually begin their conversations by a kind of small talk -a casual form of conversation that "breaks the ice" or fills an awkward silence between people . That is to say , small talk means the little things we talk about to start a conversation . In English-speaking countries such as Britain, people often make small talk about the weather. " Nice day, isn't it?" "Terrible weather , isn't it?" However, we still have something special about small talk. It must be about something which both people have the same opinion about. The purpose of small talk is to let both people agree on something. This makes meeting people easier and more comfortable . People usually agree about the weather, so it is a safe topic for small talk. But people often disagree about religion or politics so these are not suitable topics for small talk. The topics for small talk also depend on where the conversation is taking place. At basketball matches, people make small talk about the game they are watching. "Great game , isn't it?" At train stations, people may talk about the transport system . " The train service is terrible, isn't it?"
Output: What is the favorite topic of small talk for English people ?
English is a language spoken all around the world. There are more than 42 countries where the majority of the people speak English. Most native speakers of English are found in the United Kingdom, the United States, Canada, Australia, South Africa, Ireland and New Zealand. In total, for more than 375 million people, English is their mother tongue. An equal number of people learn English as a second language. These people will perhaps speak the language of their own country at home with their family, but the language of the government, schools, newspapers and TV is English. However, the number of people who learn English as a foreign language is more than 750 million. Everywhere in the world children go to school to learn English. In China, students learn English at school as a foreign language, except for those in hong Kong, where many people speak English as a first or a second language. In only fifty years, English has developed into the language most widely spoken and used in the world. English is the working language of most international organizations, international trade and tourism. English is also the language of global culture, such as popular music and the Internet. You can listen to English songs on the radio or use English to communicate with people around the world through the Internet. With so many people communicating in English every day, it will become more and more important to have a good knowledge of English.
Output: In China we are learning English as a     .
When the series was revisited for the 10 year anniversary, both Northstar and Aurora are later killed by Weapon X (Wolverine) and Kirika (X-23 in the main Marvel Universe).
Output: Which fictional universe is Northstar from?
The Ielemia Ministry was the 11th ministry of the Government of Tuvalu, led by Prime Minister Apisai Ielemia.
Output: Who was elected leader of Ielemia Ministry?
Your respiratory system is made up of the tissues and organs that allow oxygen to enter your body and carbon dioxide to leave your body. Organs in your respiratory system include your: Nose. Mouth. Larynx. Pharynx. Lungs. Diaphragm. The organs of the respiratory system move air into and out of the body. These structures are shown below (Figure 1.1). What do you think is the purpose of each of these organs? The nose and the nasal cavity filter, warm, and moisten the air you breathe. The nose hairs and the mucus produced by the cells in the nose catch particles in the air and keep them from entering the lungs. Behind the nasal cavity, air passes through the pharynx, a long tube. Both food and air pass through the pharynx. The larynx, also called the "voice box," is found just below the pharynx. Your voice comes from your larynx. Air from the lungs passes across thin tissues in the larynx and produces sound. The trachea, or windpipe, is a long tube that leads down to the lungs, where it divides into the right and left bronchi. The bronchi branch out into smaller bronchioles in each lung. There is small flap called the epiglottis that covers your trachea when you eat or drink. The muscle controlling the epiglottis is involuntary and prevents food from entering your lungs or wind pipe. The bronchioles lead to the alveoli. Alveoli are the little sacs at the end of the bronchioles (Figure 1.2). They look like little bunches of grapes. Oxygen is exchanged for carbon dioxide in the alveoli. That means oxygen enters the blood, and carbon dioxide moves out of the blood. The gases are exchanged between the blood and alveoli by simple diffusion. The diaphragm is a sheet of muscle that spreads across the bottom of the rib cage. When the diaphragm contracts, the chest volume gets larger, and the lungs take in air. When the diaphragm relaxes, the chest volume gets smaller, and air is pushed out of the lungs. "Grape-like" alveoli in the lungs.
Output: what keeps food out of the lungs?
"Cooking With Kids creates fun and food for the family. Kate Heyhoe gives simple practical tips on how to bring the family together for mealtime magic." --Linda Gassenheimer, award-winning author of Dinner in Minutes "I have just helped my four year old granddaughter Jessica to make stuffed eggs. What fun it is to cook with a new generation and what a joy now to have a brilliant new book like Cooking With Kids to pass on a passion for life and its healthy pleasures to a child!" --Graham Kerr, International Culinary Consultant "Like millions of moms, I want to prepare delicious, nutritious meals for my family, and after working all day in the restaurant, I also want to spend quality time with my sons. Cooking together is the natural solution. But in the kitchen, you need the proper tools to do the job well; Cooking With Kids is just the tool to get you started." --Chef Mary Sue Milliken, TV hostess, cookbook author "In Cooking With Kids, Kate Heyhoe brings kids into the kitchen and teaches them not only great tasting recipes but cooking fundamentals such as how to hold a knife, set a table and how to survive in a supermarket. With families' busy schedules, this book is a wonderful sourcebook for family interaction." --Emily Luchetti, executive pastry chef "Seize the moment, and a copy of this delightful cooking guide, then call the children to the kitchen to experience the joy of an often neglected pleasure of family life---cooking food together." --Marcel Desaulniers, author of Death by Chocolate "In Cooking with Kids, Kate Heyhoe takes your hand and leads you through the kitchen on a most delightful tour. The book is packed with easy-to-understand guidance and simple, tasty recipes that will delight kids of any age, and that includes every inner child who never learned the secrets of the kitchen. " --Michele Anna Jordan, author of Home Cooking
Output: Who is the author of Cooking with Kids?
Most musicians agree that the best violins were made in Cremona, Italy, about 200 years ago. They even sound better than violins made today. Violin makers and scientists try to make instruments like the old Italian violins. But they aren't the same. Why are these old Italian violins so special? Many people think they have an answer. Some people think it is the age of the violins. But there is a problem here. Not all old violins sound wonderful. Only those from Cremona are special. So age cannot be the answer. Other people think the secret to those violins is the wood. The wood of the violin is very important. It must be from certain kinds of trees. It must not be too young or too old. Perhaps the violin makers of Cremona knew something special about wood for violins. But the kind of wood may not be so important. It may be more important to cut the wood in a special way. Wood for a violin must be cut very carefully. It has to be the right size and shape. The smallest difference will change the sound of the violin. Musicians sometimes think that this is the secret of the Italians. Size and shape may not be the answer either. Scientists make new violins that are exactly the same size and shape. But the new violins still do not sound as good as the old one. Some scientists think the secret may be the varnish , which covers the wood of the violin and makes it look shiny. It also helps the sound of the instrument. Since no one knows what the Italian violin makers used in their varnish, no one can make the same varnish today. There may never be other violins like the violins of Cremona. And there are not many of the old violins left. So these old violins are becoming more and more precious.
Output: What is still unclear about Cremona violins according to the writer?
Eponine Thenardier (/eponin tenrdie/; French: (epnin tenadje)), also referred to as the ''Jondrette girl'', is a fictional character in the 1862 novel Les Miserables by Victor Hugo.
Output: In which fictional work is Éponine a character?