niryuu/sni-each-converted huggingface dataset:
Nordisk familjebok (Swedish: (nusk famljbuk), Nordic Family Book) is a Swedish encyclopedia that was published in print form between 1876 and 1957, and that is now fully available in digital form via Project Runeberg at Linkoping University.
Output: On what date did Nordisk familjebok end?
A single soldier arriving in Mexico in 1520 was carrying smallpox and thus initiated the devastating plagues that swept through the native populations of the Americas. The European diseases that ravaged the indigenous inhabitants of the Americas also severely affected the various Maya groups of Peten. It is estimated that there were approximately 30,000 Ch'ol and Ch'olti' Maya in western Peten at the start of the 16th century. Between 1559 and 1721 they were devastated by a combination of disease, war and enforced relocations. When Nojpeten fell in 1696 there were approximately 60,000 Maya living around Lake Peten Itza, including a considerable number of refugees from other areas. It is estimated that 88% of the inhabitants died during the first decade of colonial rule because of disease and war. Although disease was responsible for the majority of deaths, internecine warfare between rival Maya groups and Spanish expeditions also took their toll.
Output: Which killed more inhabitants, disease or war?
Anna Wolff-Poweska (born 1941) is a Polish historian and political scientist specialising in Polish-German relations.
Output: What is the nationality of Anna Wolff-Powęska?
Yana De Leeuw (born 6 September 1990) is a Belgian female former volleyball player, playing as a setter.
Output: Which sex or gender can Yana De Leeuw be described as?
Jacques Demy died of AIDS (information given in Agnes Varda's 2008 autobiographical movie Les Plages d'Agnes) in 1990 at age 59 and was interred in the Montparnasse Cemetery in Montparnasse.
Output: In which cemetary is Jacques Demy buried?
We present RADAR--a rigorously annotated database of A-to-I RNA editing (available at [Link] The identification of A-to-I RNA editing sites has been dramatically accelerated in the past few years by high-throughput RNA sequencing studies. RADAR includes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), mice (Mus musculus) and flies (Drosophila melanogaster), together with extensive manually curated annotations for each editing site. RADAR also includes an expandable listing of tissue-specific editing levels for each editing site, which will facilitate the assignment of biological functions to specific editing sites.
Output: Which annotated database of A-to-I RNA editing is available?
A time capsule buried by Apple founder Steve Jobs 30 years ago has been discovered after its location was long forgotten.In 1983, the young tech innovator was attending a conference in Aspen when he and the group decided to bury as a stunt during a design convention. The tube that was filled with an eclectic collection of goods- ranging from the then-new apple mouse to a six-pack of beer for the people who discovered the time capsule- was meant to be dug up 20 years later. There was a problem with that plan, however, as everyone involved forgot where it was buried. The final discovery happened at the hands of the crew from the National Geographic Channel's reality show called Diggers.The discovery was well documented and is surely going to be featured on an upcoming episode, and even the experts had problems finding this particular treasure. CNET reports that in spite of their preparations and clear idea of where the 13-foot-long tube was, it still took them two hours to dig it up using heavy machinery. To anyone removed from the tech industry, the accomplishment in finding the tube appears to be the biggest accomplishment. To others, the most interesting object would likely be the 'Lisa' mouse placed in the tube by the hands of a then-28-year-old Jobs.The Lisa Mouse, which Jobs named after his daughter, was one of the first commercial computer mice soled publicly, making it a rarity at the time. The Aspen Historical Society is going to help the show creators catalogue the tube's contents- but no word yet whether or not the Diggers cracked open one of the six bottles of Boddington's Ale that was left inside for the people who found the tube.
Output: Who found the time capsule buried by Steve Jobs?
Lamp2a acts as a receptor in the lysosomal membrane for substrate proteins of chaperone-mediated autophagy. Using antibodies specific for the cytosolic tail of lamp2a and others recognizing all lamp2 isoforms, we found that in rat liver lamp2a represents 25% of lamp2s in the lysosome. We show that lamp2a levels in the lysosomal membrane in rat liver and fibroblasts in culture directly correlate with rates of chaperone-mediated autophagy in a variety of physiological and pathological conditions. The concentration of other lamp2s in the lysosomal membrane show no correlation under the same conditions. Furthermore, substrate proteins bind to lamp2a but not to other lamp2s. Four positively-charged amino acids uniquely present in the cytosolic tail of lamp2a are required for the binding of substrate proteins. Lamp2a also distributes to an unique subpopulation of perinuclear lysosomes in cultured fibroblasts in response to serum withdrawal, and lamp2a, more than other lamp2s, tends to multimerize. These characteristics may be important for lamp2a to act as a receptor for chaperone-mediated autophagy.
Output: Which is the receptor for substrates of Chaperone Mediated Autophagy?
Atefan Harabin (born 4 May 1957) is a former Slovak judge and politician, member of the HZDS party and former Minister of Justice of Slovakia from 4 July 2006 to 23 June 2009.
Output: The nationality of Štefan Harabin was what?
Since 2011, the mayor of Kvalsund is Ragnar Olsen, who represents the Labour Party.
Output: Who was in charge of Kvalsund?
Downbelow Station is a science fiction novel written by C. J. Cherryh and published in 1981 by DAW Books.
Output: Who was the publisher of Downbelow Station?
Philippa of Champagne, Lady of Ramerupt and of Venizy (c. 1197 -- 20 December 1250) was the third daughter of Queen Isabella I of Jerusalem and Henry II, Count of Champagne.
Output: Who was Philippa of Champagne's paternal figure?
In October 1932, the Judicial Secretary, A.C.Davies, as directed by the Governor in Council asked the DIG to suggest the names of the revolutionary convicts with a statement showing the offences for which they had been convicted, the sentence awarded and a brief note showing their connection with the revolutionary movement with a view to transferring them to the Andamans. The DIG suggested the names of Yogendra Shukla, Basawon Singh , Shyamdeo Narayan alias Ram Singh, Ishwar Dayal Singh, Kedar Mani Shukla, Mohit Chandra Adhikari and Ram Pratap Singh. Yogendra Shukla, Kedar Mani Shukla and Shyamdeo Narayan were transferred to the Andamans in December, 1932. In 1937, Yogendra Shukla was transferred to Hazaribagh Central Jail as a result of his 46 days of hunger strike. When Sri Krishna Sinha formed the first Congress ministry in 1937, he took up the cause of political prisoners and his ministry resigned on the issue on 15 February 1938. As a result, the Viceroy conceded the demands and Yogendra Shukla along with other political prisoners was released in March, 1938.
Output: after a year Yogendra Shukla was transferred, who came to power
Motilal Nehru (6 May 1861 -- 6 February 1931) was an Indian lawyer, an activist of the Indian National Movement and an important leader of the Indian National Congress, who also served as the Congress President twice, 1919--1920 and 1928--1929.
Output: Which political party was Motilal Nehru a member of?
Princess Ingeborg Magnusdotter of Sweden, (b. 1277, Sweden -- d. 5 April or 15 August 1319), was a Danish queen consort, daughter of king Magnus III of Sweden and wife of king Eric VI of Denmark.
Output: Who fathered Ingeborg Magnusdotter of Sweden?
Looking to stop a three-game losing streak, the Raiders welcomed Derek Carr back after missing one week due to injury to face the Los Angeles Chargers. However, things did not start well for Carr as he threw an interception on his first pass of the day and the Chargers took over at the Raider 30-yard line. the defense held the Chargers to a field goal attempt from 48 yards out which was no good. The Raiders took advantage and moved the ball down the field before Carr hit Michael Crabtree from 23 yards out to give the Raiders a 7-0 lead. Neither team could muster much offense until midway through the second quarter when the Chargers moved 82 yards and scored on a Melvin Gordon touchdown run from one yard out to tie the game. With, 1:34 remaining in the half, the Raiders moved into Charger territory and connected on a Giorgio Tavecchio 44-yard field goal as time expired to give the Raiders a 10-7 lead at the half. On their first possession of the second half, the Raiders moved deep into Charger territory, but managed no points as Carr was intercepted for the second time in the game. The teams exchanged punts and fumbles as the game moved into the fourth quarter. The Chargers finally managed some offense as Philip Rivers hit Melvin Gordon for a six-yard touchdown pass to give the Charger at 14-10 lead. On their ensuing possession, Cordarrelle Patterson took the ball on an end around and scampered 47 yards for a touchdown. Giorgio Tavecchio would, however, miss the ensuing point after to leave the Raider lead at two points, 16-14. After exchanging punts, the Chargers took over with 4:09 remaining in the game. Rivers hit Hunter Henry for a 23-yard pass play to move the ball into Raider territory. with less than two minutes remaining, the Chargers moved the ball to the Raider 10 yard line and lined up for the game-winning field goal with three second left in the game. The field goal was good and the Raiders suffered their fourth straight loss, falling to 2-4 on the season. The four losses through six gamed equaled the number of losses they suffered the entire season the prior year. The Raider defense again struggled, giving up 343 total yards while the offense struggled as well, managing only 274 yards. Carr's two interceptions proved costly in his return. After the game, the team said his poor play was not due to his injury.
Output: Who scored more points in the first half, Raiders or Chargers?
The Nicobar parakeet is classified as near-threatened by the IUCN.
Output: What is the endangered status of Nicobar parakeet?
Tata Prima is a range of heavy trucks produced by Tata Daewoo, a wholly owned subsidiary of Tata Motors of India.
Output: By which company, Tata Prima has been manufactured?
The efficacy of RTS,S/AS01 as a vaccine for malaria is being tested in a phase 3 clinical trial. Early results show significant, albeit partial, protection against clinical malaria and severe malaria. To ascertain variations in vaccine efficacy according to covariates such as transmission intensity, choice of adjuvant, age at vaccination, and bednet use, we did an individual-participant pooled analysis of phase 2 clinical data. We analysed data from 11 different sites in Africa, including 4453 participants. We measured heterogeneity in vaccine efficacy by estimating the interactions between covariates and vaccination in pooled multivariable Cox regression and Poisson regression analyses. Endpoints for measurement of vaccine efficacy were infection, clinical malaria, severe malaria, and death. We defined transmission intensity levels according to the estimated local parasite prevalence in children aged 2-10 years (PrP), ranging from 5% to 80%. Choice of adjuvant was either AS01 or AS02. Vaccine efficacy against all episodes of clinical malaria varied by transmission intensity (p=0001). At low transmission (PrP 10%) vaccine efficacy was 60% (95% CI 54 to 67), at moderate transmission (PrP 20%) it was 41% (21 to 57), and at high transmission (PrP 70%) the efficacy was 4% (-10 to 22). Vaccine efficacy also varied by adjuvant choice (p<00001)--eg, at low transmission (PrP 10%), efficacy varied from 60% (95% CI 54 to 67) for AS01 to 47% (14 to 75) for AS02. Variations in efficacy by age at vaccination were of borderline significance (p=0038), and bednet use and sex were not significant covariates. Vaccine efficacy (pooled across adjuvant choice and transmission intensity) varied significantly (p<00001) according to time since vaccination, from 36% efficacy (95% CI 24 to 45) at time of vaccination to 0% (-38 to 38) after 3 years. Vaccine efficacy against clinical disease was of limited duration and was not detectable 3 years after vaccination. Furthermore, efficacy fell with increasing transmission intensity. Outcomes after vaccination cannot be gauged accurately on the basis of one pooled efficacy figure. However, predictions of public-health outcomes of vaccination will need to take account of variations in efficacy by transmission intensity and by time since vaccination. Medical Research Council (UK); Bill & Melinda Gates Foundation Vaccine Modelling Initiative; Wellcome Trust.
Output: RTS S AS01 vaccine was developed to prevent which disease?
Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.)
Output: Which enzyme is inhibited by a drug fostamatinib?
Mary Hoyt Wiborg was born on January 28, 1888, to Frank Bestow Wiborg in Cincinnati.
Output: What is the name of Mary Hoyt Wiborg father?
Fallingwater is a house built over a waterfall in Southwestern Pennsylvania. Frank Lloyd Wright, America's most famous architect, designed the house in 1935. It instantly became famous, and today it is a National Historic Landmark. Guided House Tour This tour features all the major rooms of the house and lasts about one hour. Photography is not permitted during this tour. The Guided House Tour allows children six-year-old and older to enjoy the house with their parents. Adults --$$ 20. 00 with advance purchase. --$$ 23. 00 when purchased on site Youth (ages 6~ 12) -- $$ 14. 00 with advance purchase -- $$ 17. 00 when purchased on site Daily from 10:00 am to 4:00 pm,except Wednesday. In-Depth Tour The tour is best if you desire a greater understanding of what Wright was seeking to create with his masterwork. The number of visitors on each tour is limited and photography is permitted for personal use only. Children nine years and older may accompany adults on this tour. $ 65. 00 per person(Available by advance ticket purchase only) Daily from 10: 00 am to 4: 00 pm Sunset Tour As afternoon turns to evening, the changing light allows you to see Fallingwater from an entirely new perspective. The number of visitors is limited and photography is permitted for personal use only. Children under nine-years-old are not permitted on this tour. $ 110. 00 per person(Available by advance ticket purchase only) May, June, & September-Saturdays at 4:30 p. m. July & August-Fridays and Saturdays at 4:45 p. m. Brunch Tour The guests join their guide for brunch before they leave. Children nine years and older may accompany adults on this tour. Please allow three hours total for this experience. $ 115. 00 per person(Available by advance ticket purchase only) May through September --Saturdays & Sundays at 9:00 a. m
Output: Where can a couple with an eight-year-old girl make a tour?
Wanxian Bridge, or Wanzhou Bridge (simplified Chinese: ; traditional Chinese: ; pinyin: Wanxian Changjiang Daqiao), is a reinforced concrete arch bridge built over the Yangtze River in 1997.
Output: What is the surface of Wanxian Bridge made of?
The Centers for Disease Control and Prevention (CDC) recently announced trends in fruit and vegetable consumption among adults. Since 2000, the CDC has made efforts with goals of getting 75% of Americans to eat two or more servings of fruit a day and 50% of Americans to eat three or more servings of vegetables a day. Unfortunately, Americans aren't meeting these modest targets. Although a diet high in fruit and vegetables can reduce the risk of many diseases, Americans just aren't getting enough. In fact, since 2000, the amount of vegetables Americans are eating has stayed the same and the amount of fruit Americans are eating has gone down. The CDC also finds that only about a third of adults are eating their expected servings of fruit, and just over a quarter of adults are eating their expected servings of vegetables. So why aren't Americans getting their expected servings of fruit and vegetables? It turns out that Americans might be spoiled when it comes to their produce. A national survey conducted by Fruit2day reveals that nearly half of Americans leave fruit in their fridges until it rots with people in Boston among the worst and those in New York and Los Angeles among the best. Sadly, most Americans admit to leaving fruit in the fridge for more than a week. There are many reasons why Americans don't eat their fruit or vegetables, including the inconvenience of having to wash or peel it. Fruit2day offers consumers a surprising and convenient way to enjoy the goodness of fruit. "With no added sugar, natural juices and two full servings of fruit, our Fruit2day line has really captured the imaginations of health-conscious consumers who are actively looking to get more fruit in their diets," said Hanno Holm, president and chief executive officer of Hero-White Wave. "Fruit2day makes getting more fruit in one's diet easier for any daily snack routine."
Output: In which city are people most likely to leave fruit in their fridge?
Do you know what your blood type is? Maybe you have heard people say that they have type A or type O blood. Blood type is a way to describe the type of antigens, or proteins, on the surface of red blood cells (RBCs). There are four blood types; A, B, AB, and O. 1. Type A blood has type A antigens on the RBCs in the blood. 2. Type AB blood has A and B antigens on the RBCs. 3. Type B has B antigens on the RBCs. 4. Type O does not have either A or B antigens. The ABO blood group system is important if a person needs a blood transfusion. A blood transfusion is the process of putting blood or blood products from one person into the circulatory system of another person. The blood type of the recipient needs to be carefully matched to the blood type of the donor. Thats because different blood types have different types of antibodies, or proteins, released by the blood cells. Antibodies attack strange substances in the body. This is a normal part of your immune response, which is your defense against disease. For example, imagine a person with type O blood was given type A blood. First, what type of antibodies do people with type O blood produce? They produce anti-A and anti-B antibodies. This means, if a person with type O blood received type A blood, the anti-A antibodies in the persons blood would attack the A antigens on the RBCs in the donor blood ( Figure 1.1). The antibodies would cause the RBCs to clump together, and the clumps could block a blood vessel. This clumping of blood cells could cause death. A person with type O blood has A and B antibodies in his/her plasma; if the person was to get type A blood instead of type O, his/her A antibodies would attach to the antigens on the RBCs and cause them to clump together. People with type A blood produce anti-B antibodies, and people with type B blood produce anti-A antibodies. People with type AB blood do not produce either antibody. The second most important blood group system in human blood is the Rhesus (Rh) factor. A person either has, or does not have, the Rh antigen on the surface of their RBCs. If they do have it, then the person is positive. If the person does not have the antigen, they are considered negative. Recall that people with type O blood do not have any antigens on their RBCs. As a result, type O blood can be given to people with blood types A, B, or AB. If there are no antigens on the RBCs, there cannot be an antibody reaction in the blood. People with type O blood are often called universal donors. The blood plasma of AB blood does not contain any anti-A or anti-B antibodies. People with type AB blood can receive any ABO blood type. People with type AB blood are called universal recipients because they can receive any blood type. The antigens and antibodies that define blood type are listed as follows ( Table 1.1). Blood Type Antigen Type Plasma Antibodies A B AB O A B A and B none anti-B anti-A none anti-A, anti-B Can Receive Blood from Types A,O B,O AB, A, B, O O Can Donate Blood to Types A, AB B, AB AB AB, A, B, O
Output: a person with blood type o can donate blood to types
Marlow H. Colvin (born 1964) is a former Democratic member of the Illinois House of Representatives, representing the 33rd District from 2001 to 2012.
Output: Which position was held by Marlow H. Colvin?
The Giordano Bruno Foundation (German: Giordano-Bruno-Stiftung) is a Germany-based non-profit foundation under public law that pursues the ''Support of Evolutionary Humanism''.
Output: The Giordano Bruno Foundation was named for whom?
A volcano is a vent through which molten rock and gas escape from a magma chamber. Volcanoes differ in many features, such as height, shape, and slope steepness. Some volcanoes are tall cones and others are just cracks in the ground (Figure 1.1). As you might expect, the shape of a volcano is related to the composition of its magma. Composite volcanoes are constructed of felsic to intermediate rock. The viscosity of the lava means that eruptions at these volcanoes are often explosive. Viscous lava cannot travel far down the sides of the volcano before it solidifies, which creates the steep slopes of a composite volcano. In some eruptions the pressure builds up so much that the material explodes as ash and small rocks. The volcano is constructed layer by layer, as ash and lava solidify, one upon the other (Figure 1.3). The result is the classic cone shape of composite volcanoes. Mount St. Helens was a beautiful, classic, cone-shaped volcano. In May 1980 the volcano blew its top off in an explosive eruption, losing 1,300 feet off its summit. Mt. Fuji in Japan is one of the worlds most easily recognized composite volca- noes. Shield volcanoes get their name from their shape. Although shield volcanoes are not steep, they may be very large. Shield volcanoes are common at spreading centers or intraplate hot spots (Figure 1.4). Hawaii has some spectacular shield volcanoes including Mauna Kea, which is the largest mountain on Earth from base to top. The mountain stands 33,500 ft high, about 4,000 feet greater than the tallest mountain above sea level, Mt. Everest. A cross section of a composite volcano reveals alternating layers of rock and ash: (1) magma chamber, (2) bedrock, (3) pipe, (4) ash layers, (5) lava layers, (6) lava flow, (7) vent, (8) lava, (9) ash cloud. Frequently there is a large crater at the top from the last eruption. Mauna Kea on the Big Island of Hawaii is a classic shield volcano. The lava that creates shield volcanoes is fluid and flows easily. The spreading lava creates the shield shape. Shield volcanoes are built by many layers over time and the layers are usually of very similar composition. The low viscosity also means that shield eruptions are non-explosive. Cinder cones are the most common type of volcano. A cinder cone has a cone shape, but is much smaller than a composite volcano. Cinder cones rarely reach 300 meters in height, but they have steep sides. Cinder cones grow rapidly, usually from a single eruption cycle. These volcanoes usually flank shield or composite volcanoes. Many cinder cones are found in Hawaii. A lava fountain erupts from Puu Oo, a cinder cone on Kilauea. Cinder cones are composed of small fragments of rock, such as pumice, piled on top of one another. The rock shoots up in the air and doesnt fall far from the vent. The exact composition of a cinder cone depends on the composition of the lava ejected from the volcano. Cinder cones usually have a crater at the summit. Most cinder cones are active only for a single eruption. Click image to the left or use the URL below. URL:
Output: this is the largest shield volcano on earth.
The Romano-Ward long-QT Syndrome (LQTS) is an autosomal dominant inherited trait characterized by prolonged QT interval on ECG, life-threatening arrhythmias, syncope, and sudden death in affected individuals. A gene responsible for this disorder has been shown to be linked to the Harvey ras-1 locus (H-ras-1) DNA marker on the short arm of chromosome 11 (11p) in 7 families. The purpose of this study was to determine, by analyzing 23 families with LQTS for linkage to chromosome 11p, whether evidence exists for more than one gene causing LQTS (ie, locus heterogeneity). Twenty-three families (262 family members) were clinically evaluated using medical histories, ECGs, and Holter recordings. Each corrected QT interval (QTc) were determined using Bazett's formula. Blood for DNA extraction and cell line immortalization was obtained after informed consent. Southern blotting and polymerase chain reaction were performed, and linkage analysis carried out using the LINKAGE computer program (v 5.03). Genetic heterogeneity was determined using the HOMOG 2 (v 2.51) computer program. Twenty-three families were studied for evidence of linkage to chromosome 11p using the H-ras-1 locus probe pTBB-2 and multiple flanking markers, including tyrosine hydroxylase (TH). Two-point linkage analysis using pTBB-2 and TH markers was consistent with linkage in 15 of 23 families, with the maximum single-family LOD score of +3.038 occurring at theta = 0. However, 8 of 23 families had negative LOD scores, with the values in 4 families being less than -2 at theta = 0, consistent with exclusion of linkage. Analysis with the HOMOG program was consistent with genetic heterogeneity (P < .0001). Multipoint linkage data using pTBB-2 and TH were also examined for evidence of heterogeneity. HOMOG analysis of multipoint LOD scores from 100 cM surrounding the H-ras-1 locus also supported heterogeneity (P < .001). In the 23 families with LQTS analyzed for linkage to the H-ras-1 locus on chromosome 11p15.5, 15 of 23 families had LOD scores consistent with linkage. The remaining 8 of 23 families had negative LOD scores, 4 of which were definitively excluded from linkage. Thus, genetic heterogeneity is definitively (P < .001) demonstrated for this disorder.
Output: What is the mode of inheritance of Romano Ward long QT syndrome?
Elie Lacoste (18 September 1745, Montignac - 26 November 1806, Montignac) was a French politician during the French Revolution.
Output: What is the native tongue of Élie Lacoste?
Fafhrd and the Gray Mouser are two sword-and-sorcery heroes appearing in stories written by American author Fritz Leiber.
Output: Who is the author of Fafhrd and the Gray Mouser?
The mechanisms underlying lithium's therapeutic efficacy in the chronic treatment of bipolar disorder are not clearly understood. Useful insights can be obtained by identifying genes that are differentially regulated during chronic lithium treatment. Toward this end, we have used microarray technology to identify mRNAs that are differentially expressed in a human neuronal cell line that has been continuously maintained in therapeutic levels of lithium for 33 days. Significantly, unlike other transcriptomes where predominantly rodent cells were used and a limited number of genes probed, we have used human cells probed with more extensive 44,000 gene microarrays. A total of 671 differentially regulated transcripts, after correcting for false discovery rates, were identified, of which 347 and 324, respectively, were found to be up- and downregulated. Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, was the most upregulated while tribbles homolog 3 (TRB3), a pro-apoptotic protein, was the most downregulated, implying a beneficial effect of lithium on neuronal cells. Several of the most highly regulated genes are novel, uncharacterized and encode proteins of unknown function. Differentially expressed genes associated with phosphoinositide metabolism include those encoding phosphatidyl inositol 4-phosphate 5-kinase type II alpha (PIP5K2A), WD repeat domain, phosphoinositide interacting 1 protein (WIPI49), tribbles homolog 3 (TRB3) and sorting nexin 14 (SNX14). A protein interactome using some of the saliently regulated genes identified protein kinase C (PKC) as a major target for lithium action while a global analysis of all 671 differentially expressed genes identified the mitogen-activated protein kinase pathway as the most regulated. The list of highly regulated genes, besides encoding putative targets for antimanic agents, should prove useful in defining novel pathways, or to better understand the mechanisms, underlying the mood stabilization process.
Output: What type of enzyme is peroxiredoxin 2 (PRDX2)?
A rock is a naturally formed, non-living Earth material. Rocks are made of collections of mineral grains that are held together in a firm, solid mass (Figure 1.1). How is a rock different from a mineral? Rocks are made of minerals. The mineral grains in a rock may be so tiny that you can only see them with a microscope, or they may be as big as your fingernail or even your finger (Figure Rocks are identified primarily by the minerals they contain and by their texture. Each type of rock has a distinctive set of minerals. A rock may be made of grains of all one mineral type, such as quartzite. Much more commonly, rocks are made of a mixture of different minerals. Texture is a description of the size, shape, and arrangement of mineral grains. Are the two samples in Figure 1.3 the same rock type? Do they have the same minerals? The same texture? The different colors and textures seen in this rock are caused by the presence of different minerals. A pegmatite from South Dakota with crystals of lepidolite, tourmaline, and quartz (1 cm scale on the upper left). Sample 2 Crystals are tiny or microscopic Magma erupted and cooled quickly Andesite As seen in Table 1.1, these two rocks have the same chemical composition and contain mostly the same minerals, but they do not have the same texture. Sample 1 has visible mineral grains, but Sample 2 has very tiny or invisible grains. The two different textures indicate different histories. Sample 1 is a diorite, a rock that cooled slowly from magma (molten rock) underground. Sample 2 is an andesite, a rock that cooled rapidly from a very similar magma that erupted onto Earths surface. A few rocks are not made of minerals because the material they are made of does not fit the definition of a mineral. Coal, for example, is made of organic material, which is not a mineral. Can you think of other rocks that are not made of minerals? Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:
Output: which one of these rocks does not contain minerals?
INteractive Codon usage Analysis (INCA) provides an array of features useful in analysis of synonymous codon usage in whole genomes. In addition to computing codon frequencies and several usage indices, such as 'codon bias', effective Nc and CAI, the primary strength of INCA has numerous options for the interactive graphical display of calculated values, thus allowing visual detection of various trends in codon usage. Finally, INCA includes a specific unsupervised neural network algorithm, the self-organizing map, used for gene clustering according to the preferred utilization of codons. INCA is available for the Win32 platform and is free of charge for academic use. For details, visit the web page [Link] or contact the author directly. Software is accompanied with a user manual and a short tutorial.
Output: Which tool employs self organizing maps for analyzing synonymous codon usage?
Baron Mayer Amschel de Rothschild (29 June 1818 -- 6 February 1874) was an English businessman and politician of the English branch of the Rothschild family.
Output: What family lineage was Mayer Amschel de Rothschild part of?
Watanabe et al (Reports, 12 April 2013, p. 195) study the yeast SWR1/SWR-C complex responsible for depositing the histone variant H2A.Z by replacing nucleosomal H2A with H2A.Z. They report that reversal of H2A.Z replacement is mediated by SWR1 and related INO80 on an H2A.Z nucleosome carrying H3K56Q. Using multiple assays and reaction conditions, we find no evidence of such reversal of H2A.Z exchange.
Output: Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
City Varieties The Headrow, Leeds.Tel.430808. Oct 10--11 only.A Night at the Varieties.All the fun of an old music hall with Barry Cryer, Duggle Brown, 6 dancers, Mystina, Jon Barker, Anne Dural and the Tony Harrison Trio; Laugh again at the old jokes and listen to your favorite songs. Performances: 8 pm nightly. Admission: L5; under 16 or over 60: L4. York Theatre Royal St Leonard's Place, York.Tel.223568. Sept 23--Oct 17 Groping for Words--a comedy by Sue Townsend.Best known for her Adrian Mole Diaries, Townsend now writes about an evening class, which two men and a woman attend.A gentle comedy. Admission: First night, Mon: L2; Tues--Fri: L3.25--5.50; Sat: L3.50--5.75. Halifax Playhouse King's Cross Street, Halifax.Tel.365998. Oct 10--17 On Golden Pond by Ernest Thompson.This is a magical comedy about real people.A beautifully produced, well-acted play for everyone.Don't miss it. Performances: 7:30 pm. Admission: L2.Mon: 2 seats for the price of one. Grand Theatre Oxford Street, Leeds.Tel.502116. Restaurant and Cafe. Oct--17 The Secret Diary of Adrian Mole, Aged 13.Sue Townsend's musical play, based on her best-selling book. Performances: Evenings 7:45.October 10--17, at 2:30 pm.No Monday performances. Admission: Tues--Thurs: L2--5; Fri & Sat: L2--6.
Output: Which theatre offers the cheapest seat?
Chediak-Higashi syndrome (CHS) is an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. CHS results from mutations in the lysosomal trafficking regulator (LYST) gene, which encodes a 425-kD cytoplasmic protein of unknown function. The goal of this study was to identify proteins that interact with LYST as a first step in understanding how LYST modulates lysosomal exocytosis. Fourteen cDNA fragments, covering the entire coding domain of LYST, were used as baits to screen five human cDNA libraries by a yeast two-hybrid method, modified to allow screening in the activation and the binding domain, three selectable markers, and more stringent confirmation procedures. Five of the interactions were confirmed by an in vitro binding assay. Twenty-one proteins that interact with LYST were identified in yeast two-hybrid screens. Four interactions, confirmed directly, were with proteins important in vesicular transport and signal transduction (the SNARE-complex protein HRS, 14-3-3, and casein kinase II). On the basis of protein interactions, LYST appears to function as an adapter protein that may juxtapose proteins that mediate intracellular membrane fusion reactions. The pathologic manifestations observed in CHS patients and in mice with the homologous mutation beige suggest that understanding the role of LYST may be relevant to the treatment of not only CHS but also of diseases such as asthma, urticaria, and lupus, as well as to the molecular dissection of the CHS-associated cancer predisposition.
Output: Which syndrome is associated with mutations in the LYST gene?
Owlwoman is a fictional character, a superheroine in the DC Universe.
Output: What is the universe that Owlwoman exists in?
The Muenke syndrome (MS) is characterized by unicoronal or bicoronal craniosynostosis, midfacial hypoplasia, ocular hypertelorism, and a variety of minor abnormalities associated with a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene. The birth prevalence is approximately one in 10,000 live births, accounting for 8-10% of patients with coronal synostosis. Although MS is a relatively common diagnosis in patients with craniosynostosis syndromes, with autosomal dominant inheritance, there has been no report of MS, in an affected Korean family with typical cephalo-facial morphology that has been confirmed by molecular studies. Here, we report a familial case of MS in a female patient with a Pro250Arg mutation in exon 7 (IgII-IGIII linker domain) of the FGFR3 gene. This patient had mild midfacial hypoplasia, hypertelorism, downslanting palpebral fissures, a beak shaped nose, plagio-brachycephaly, and mild neurodevelopmental delay. The same mutation was confirmed in the patient's mother, two of the mother's sisters and the maternal grandfather. The severity of the cephalo-facial anomalies was variable among these family members.
Output: Which gene is associated with Muenke syndrome?
In February 2009, James L. Jones, then-chairman of the Atlantic Council, stepped down in order to serve as President Obama's new National Security Advisor and was succeeded by Senator Chuck Hagel.
Output: Who led Atlantic Council?
Lee Ze-ha (This is his preferred Romanization per LTI Korea, or Hangul: ) is a South Korean writer, poet and painter.
Output: The nationality of Lee Ze-ha is?
Metastasis is the major factor affecting patient survival in ovarian cancer. However, its molecular mechanisms remain unclear. Our study used isogenic pairs of low- and high-invasive ovarian cancer cell lines to demonstrate the downregulation of miRNA-138 in the highly invasive cells, and its functioning as an inhibitor of cell migration and invasion. An orthotopic xenograft mouse model further demonstrated that the expression of miRNA-138 inhibited ovarian cancer metastasis to other organs. Results indicated that miR-138 directly targeted SRY-related high mobility group box 4 (SOX4) and hypoxia-inducible factor-1 (HIF-1), and overexpression of SOX4 and HIF-1 effectively reversed the miR-138-mediated suppression of cell invasion. Epidermal growth factor receptor acted as the downstream molecule of SOX4 by way of direct transcriptional control, whereas Slug was the downstream molecule of HIF-1 by way of proteasome-mediated degradation. Analysis of human ovarian tumors further revealed downregulation of miR-138 and upregulation of SOX4 in late-stage tumors. Patients with miR-138(low)/SOX(high) signature are predominant in late stage and tend to have malignant phenotypes including lymph nodes metastasis, larger ascites volume and higher tumor grade. Our study demonstrates the role and clinical relevance of miR-138 in ovarian cancer cell invasion and metastasis, providing a potential therapeutic strategy for suppression of ovarian cancer metastasis by targeting SOX4 and HIF-1 pathways.
Output: Which miRNA is targeted by SRY/Sox9?
Ricky Cooke (born 9 August 1969) is a retired male race walker from Australia.
Output: Which sex or gender can Ricky Cooke be described as?
Clinical evidence for failure with beta-lactam therapy has been lacking for patients with borderline oxacillin-resistant Staphylococcus aureus (BORSA) infections. We describe a failure of cloxacillin for a patient with endocarditis due to BORSA. The isolate also had false-negative thermonuclease and coagulase test results.
Output: What is BORSA?
The Saga of Erik the Viking is a children's novel written by the Welsh comedian Terry Jones, illustrated by Michael Foreman, and published by Pavilion in 1983.
Output: What is the name of the ilustrator of the book The Saga of Erik the Viking?
Albino Perez (died 8 August 1837) was a Mexican soldier and politician who was appointed Governor of New Mexico.
Output: Which was the position that Albino Pérez held?
Missense mutations in ubiquilin 2 (UBQLN2) cause ALS with frontotemporal dementia (ALS-FTD). Animal models of ALS are useful for understanding the mechanisms of pathogenesis and for preclinical investigations. However, previous rodent models carrying UBQLN2 mutations failed to manifest any sign of motor neuron disease. Here, we show that lines of mice expressing either the ALS-FTD-linked P497S or P506T UBQLN2 mutations have cognitive deficits, shortened lifespans, and develop motor neuron disease, mimicking the human disease. Neuropathologic analysis of the mice with end-stage disease revealed the accumulation of ubiquitinated inclusions in the brain and spinal cord, astrocytosis, a reduction in the number of hippocampal neurons, and reduced staining of TAR-DNA binding protein 43 in the nucleus, with concomitant formation of ubiquitin
Output: Which human disease is associated with mutated UBQLN2
Almost nothing is left of the Bastille except some remains of its stone foundation that were relocated to the side of the Boulevard Henri IV. Historians were critical of the Bastille in the early 19th century, and believe the fortress to have been a relatively well-administered institution, but deeply implicated in the system of French policing and political control during the 18th century.
Output: What material was used for Bastille?
School leaders from around the country gathered at the White House on November 19 for"Connected to the Future," a conference about digital technology in education.Connected is the Obama Government's five-year plan to support the growth of digital learning in schools.This growth includes equipping America's schools with high-speed broadband Internet . At the conference,President Barack Obama said the U.S.Department of Education is taking steps to help educators and school districts as they change to digital learning.The department created new guidelines to help schools work to improve their technological infrastructure .The guidelines are also designed to help schools choose the right digital devices and set up policies for their proper use. "We have to do more to offer our children a world-class education,"Obama told the crowd of school leaders."We have to improve our education level if we are going to make sure that every child in America can go as far as their dreams and talents will take them." According to Cecilia Muoz,director of the Domestic Policy Council,less than 40% of public schools in America have high-speed Internet access in their classrooms.She believes that Connected will make America a leader in using technology to educate students. Muoz mentioned the Mooresville school district as a success story.Mooresville provides each student in grades 3 through 12 with a device,and uses a mostly digital subject.Muoz said Mooresville now ranks third in test scores and second in graduation rates in the state. At the end of the president's speech,1,200 school leaders attending the event signed the Future Ready District Pledge on their iPads.It promises the education leaders to help develop a culture of learning through technology at their schools,and to support teachers and students in using technology. "Every child deserves a chance at a world-class education,"Obama added."That's what makes our nation great."
Output: Who will take charge of putting the plan into practice?
Elisabeth of Nuremberg (1358 -- 26 July 1411) was the daughter of Frederick V, Burgrave of Nuremberg and Elisabeth of Meissen.
Output: What was the name of Elisabeth of Nuremberg mother?
Cafeteria Nipponica is a simulation video game developed and published by Kairosoft for the Android and iOS operating systems.
Output: Which company developed Cafeteria Nipponica?
''The Bed's Too Big Without You'' is a song by English rock band The Police, released as the final single from their second studio album Reggatta de Blanc (1979).
Output: Who released The Bed's Too Big Without You album?
The 2008 Tour of Qatar was held from 27 January to 1 February 2008 in Qatar.
Output: On what date did 2008 Tour of Qatar end?
In order to determine the prevalence of latent infection due to Mycobacterium tuberculosis in drug users and to provide centres for drug users with a practical tool for tuberculosis screening, 237 drug users were subjected to the Monotest and, for reference purposes, to the Mantoux test. The overall prevalence of subjects with a tuberculin skin reaction size > or = 5 mm in the Mantoux test was 25.7%; utilizing a cut-off of > or = 10 mm, the prevalence was 11.4%. Irrespective of cut-off, the Monotest showed a sensitivity of > 90% and a specificity of > 80%. At a prevalence of 25.7%, and with cut-offs of > or = 5 or > or = 10 mm, the positive predictive value was 83% or 62.2%, respectively. Irrespective of cut-off, the negative predictive value was > 97%. In conclusion, the Monotest proved satisfactory as a tool for epidemiological screening in a population with a high prevalence for latent tuberculosis, namely drug users.
Output: The Mantoux test detects what latent infection/disease?
Juxtolena oncodina is a species of moth of the Tortricidae family.
Output: Is the taxon rank of Juxtolena oncodina species or genus?
Restless legs syndrome, now called Willis-Ekbom Disease (RLS/WED), is a sensorimotor-related sleep disorder. Little is known of the effect of RLS/WED on motor function. The current study investigated upper limb function in RLS/WED patients. We hypothesised that RLS/WED patients exhibit subtle changes in tremor amplitude but normal dexterity and movement speed and rhythmicity compared to healthy controls. RLS/WED patients (n=17, 59 7 years) with moderate disease and healthy controls (n=17, 58 6 years) completed screening tests and five tasks including object manipulation, maximal pinch grip, flexion and extension of the index finger (tremor assessment), maximal finger tapping (movement speed and rhythmicity assessment), and the grooved pegboard test. Force, acceleration, and/or first dorsal interosseus EMG were recorded during four of the tasks. Task performance did not differ between groups. Learning was evident on tasks with repeated trials and the magnitude of learning did not differ between groups. Hand function, tremor, and task learning were unaffected in RLS/WED patients. Patients manipulated objects in a normal manner and exhibited normal movement speed, rhythmicity, and tremor. Further research is needed to assess other types of movement in RLS/WED patients to gain insight into the motor circuitry affected and the underlying pathophysiology.
Output: Willis-Ekbom disease is also known as?