niryuu/sni-each-converted huggingface dataset:
Hallervorden-Spatz syndrome (HSS) is a rare autosomal recessive disorder clinically characterized by extrapyramidal signs and progressive dementia. In a typical case, the clinical symptoms become apparent during late childhood, and usually the course is protracted over a decade or more. We recently had an opportunity to study the brains of two cases of HSS with a clinical course of over 30 years. Case 1 was a 44-year-old female and case 2 was a 37-year-old male. Grossly, the brains showed severe fronto-temporal lobar atrophy with abundant spheroids and mild iron deposits in the globus pallidus, associated with features of motor neuron disease. In addition, there was diffuse sponginess in the atrophic cortex as well as widespread Alzheimer's neurofibrillary tangles (NFTs) and Lewy bodies (LBs) in the cortical and subcortical regions, including the spinal cord. Ultrastructurally, NFTs were composed of paired helical filaments, and LBs of central dense cores with radiating fibrils. Discrete immunostaining was demonstrated in NFTs and neuropil threads with various antibodies against phosphorylated tau, and in LBs with antibody against alpha-synuclein. In addition, diffuse, overlapping immunoreactivity of alpha-synuclein and phosphorylated tau was seen within the cytoplasm of many neurons. However, when LBs and NFTs coexisted within the same neurons, they were clearly segregated. The findings of our present cases as well as those reported in the literature may indicate that simultaneous and extensive occurrence of abnormal phosphorylation of tau and accumulation of alpha-synuclein may constitute cardinal pathological features of HSS with protracted clinical course.
Output: Against which protein is the antibody used for immonostaining of Lewy bodies raised?
The photo above represents water in three common states of matter. States of matter are different phases in which any given type of matter can exist. There are actually four well-known states of matter: solid, liquid, gas, and plasma. Plasma isnt represented in the iceberg photo, but the other three states of matter are. The iceberg itself consists of water in the solid state, and the lake consists of water in the liquid state. Q: Where is water in the gaseous state in the above photo? A: You cant see the gaseous water, but its there. It exists as water vapor in the air. Q: Water is one of the few substances that commonly exist on Earth in more than one state. Many other substances typically exist only in the solid, liquid, or gaseous state. Can you think of examples of matter that usually exists in just one of these three states? A: Just look around you and you will see many examples of matter that usually exists in the solid state. They include soil, rock, wood, metal, glass, and plastic. Examples of matter that usually exist in the liquid state include cooking oil, gasoline, and mercury, which is the only metal that commonly exists as a liquid. Examples of matter that usually exists in the gaseous state include oxygen and nitrogen, which are the chief gases in Earths atmosphere. A given kind of matter has the same chemical makeup and the same chemical properties regardless of its state. Thats because state of matter is a physical property. As a result, when matter changes state, it doesnt become a different kind of substance. For example, water is still water whether it exists as ice, liquid water, or water vapor. The most common states of matter on Earth are solids, liquids, and gases. How do these states of matter differ? Their properties are contrasted in the Figure 1.1. Click image to the left or use the URL below. URL: Properties of matter in different states. Q: The Figure 1.2 shows that a liquid takes the shape of its container. How could you demonstrate this? A: You could put the same volume of liquid in containers with different shapes. This is illustrated below with a beaker (left) and a graduated cylinder (right). The shape of the liquid in the beaker is short and wide like the beaker, while the shape of the liquid in the graduated cylinder is tall and narrow like that container, but each container holds the same volume of liquid. Q: How could you show that a gas spreads out to take the volume as well as the shape of its container? A: You could pump air into a bicycle tire. The tire would become firm all over as air molecules spread out to take the shape of the tire and also to occupy the entire volume of the tire.
Output: the only state in which matter has a fixed shape is
Ponds are small bodies of fresh water that usually have no outlet; ponds are often are fed by underground springs. Like lakes, ponds are bordered by hills or low rises so the water is blocked from flowing directly downhill. Lakes are larger bodies of water. Lakes are usually fresh water, although the Great Salt Lake in Utah is just one exception. Water usually drains out of a lake through a river or a stream and all lakes lose water to evaporation. Lakes form in a variety of different ways: in depressions carved by glaciers, in calderas (Figure 1.1), and along tectonic faults, to name a few. Subglacial lakes are even found below a frozen ice cap. As a result of geologic history and the arrangement of land masses, most lakes are in the Northern Hemisphere. In fact, more than 60% of all the worlds lakes are in Canada most of these lakes were formed by the glaciers that covered most of Canada in the last Ice Age (Figure 1.2). Lakes are not permanent features of a landscape. Some come and go with the seasons, as water levels rise and fall. Over a longer time, lakes disappear when they fill with sediments, if the springs or streams that fill them diminish, (a) Crater Lake in Oregon is in a volcanic caldera. Lakes can also form in volcanic craters and impact craters. (b) The Great Lakes fill depressions eroded as glaciers scraped rock out from the landscape. (c) Lake Baikal, ice coated in winter in this image, formed as water filled up a tectonic faults. Lakes near Yellowknife were carved by glaciers during the last Ice Age. or if their outlets grow because of erosion. When the climate of an area changes, lakes can either expand or shrink (Figure 1.3). Lakes may disappear if precipitation significantly diminishes. Large lakes have tidal systems and currents, and can even affect weather patterns. The Great Lakes in the United States contain 22% of the worlds fresh surface water (Figure 1.1). The largest them, Lake Superior, has a tide that rises and falls several centimeters each day. The Great Lakes are large enough to alter the weather system in Northeastern United States by the lake effect, which is an increase in snow downwind of the relatively warm lakes. The Great Lakes are home to countless species of fish and wildlife. Many lakes are not natural, but are human-made. People dam a stream in a suitable spot and then let the water back up behind it, creating a lake. These lakes are called "reservoirs." Click image to the left or use the URL below. URL:
Output: which of these is not full of fresh water?
_ (from How Do Animals Move?) Many animals scurry up tree trunks to escape enemies or find food. Some live in the treetops. Many of these animals are not only expert climbers, but they also have found interesting ways to get from tree to tree. How Do Animals Adapt?andHow Do Animals Move? are comprehensive explorations of animal adaptations and movement for young readers. Both are part of a 21 book series,The Science of Living Things. InHow Do Animals Adapt?readers learn how animals adapt to survive with respect not only to climate, darkness, food and defenses but also to offspring and people. These adaptations are well explained in double page spreads with examples clearly depicted in photographs and diagrams and developed through their accompanying captions . As the title suggests, movement is the focus ofHow Do Animals Move?Beginning with a description of the explanation of movement, the reader is exposed to the many different ways of animals movement in the air, on land, under ground and in the water. Several unconventional variations (e.g. looping of inchworms, the rectilinear motion of snakes) are included. Once again, the photographs and diagrams plainly support the double page spread discussions of animal movement. The language of both titles is simple enough for young readers without talking down to them. In both books, terminology is featured in . Some of these words are explained in the basic glossary while the majority are explained clearly in the text. Many of these terms provide readers with some fascinating, uncommon words (e.g. brachiation, potassium, skein, and estimate). As do many of Kalman's book, both of these titles have a table of contents, glossary and index which are all enough to introduce young readers to the nature of these tools. Both titles would make excellent additions to any science collection for young readers.
Output: What help to understand the articles in the books?
Luka orevic (Cyrillic: a , born 9 July 1994) is a Montenegrin footballer who plays as a forward for Spanish club SD Ponferradina on loan from FC Zenit Saint Petersburg.
Output: The birth date of Luka Đorđević is what?
Vera Grafin von Lehndorff-Steinort or Veruschka von Lehndorff (born 14 May 1939) is a German model, actress, and artist who was popular during the 1960s.
Output: The nationality of Veruschka von Lehndorff?
The natural phytoalexin resveratrol, found in grapes and red wine, recently rose to public fame for its positive effects on longevity in yeasts, worms and flies. Resveratrol anti-cancer and anti-inflammatory in vitro action on mammalian cell cultures also suggest a possible positive effect on human health and life-expectancy. To study the effects of resveratrol on vertebrate aging is obviously a particularly relevant question. We have studied resveratrol effects in a very short-lived vertebrate: the annual fish Nothobranchius furzeri. Resveratrol treatment prolonged lifespan and delayed the onset of age-related dysfunctions in this fish. This result identifies resveratrol as the first molecule which consistently retards aging in organisms as diverse as yeast, worm, fly and fish, but it also reveals the potential of this short-lived fish as an animal model for pharmacological research. Moreover, being related to stickleback (Gasterosteus aculeatus) the "pufferfishes" Takifugu and Tetraodon, and even more closely related to medaka (Oryzias latipes), it can greatly beneficiate from the recent development of genomic resources for these fish models and in the future become a complete model system for the aging research community.
Output: What can Nothobranchius furzeri be used as a model system for?
Free the Music is the fourth and second major-label studio album by American country music artist Jerrod Niemann.
Output: Which performer released Free the Music as it's album?
Stefan Deloose (born 14 January 1990) is a Belgian footballer who plays as a goalkeeper for Bornem in the Belgian Third Division.
Output: Which player position has been assigned to Stefan Deloose?
For Fall 2018, Berkeleys acceptance rate for freshman was 15.1%. Total enrollment was 41,910 - 30,574 undergraduate and 11,336 graduate students - with women accounting for 52.7% of undergraduates and 46.2% of graduate and professional students. Of enrolled freshman, nearly 54% were women and approximately 60% self-identified as persons of color. Enrolled freshman had an average weighted secondary school GPA of 4.45 (unweighted GPA of 3.92) and had an average SAT score of 1435 (average ACT score of 32). The interquartile range for SAT scores was 1340-1530, with 660-750 for reading/writing and 670-750 for math. Berkeleys enrollment of National Merit Scholarship Program was third in the nation until 2002, when participation in the National Merit program was discontinued. For 2016-17, Berkeley ranked fifth in enrollment of recipients of the National Merit Scholarship Program (136 scholars). 33% of admitted students receive federal Pell grants.
Output: In Fall of 2018 were there more women or men enrolled as freshman?
de Quervain's disease is an inadequacy into the first extensor compartment of wrist between the osteofibrous tunnel and the tendons. This mechanical conflict generates a tenosynovitis of the extensor pollicis brevis and the abductor pollicis longus tendons in first dorsal extensor compartment of the wrist. (1) To compare the clinical results obtained by longitudinal and transverse incisions and (2) the implication of clinical results in Indian population. This study was conducted at Kalpana Chawla Government Medical College, Karnal, Haryana. The inclusion criteria were positive Finkelstein's test and no response to non-surgical treatment for 6 weeks. Forty-eight patients with de Quervain's disease who did not respond to conservative treatment were operated with two different incisions. The patients were followed at 6 weeks, 3 and 6 months to compare the surgical outcomes. During a three-month follow-up, a significant difference was shown between the two methods (p = 0.0001). Results of surgical treatment with longitudinal incision were better (only one hypertrophic scar), but there were 12 postoperative complications with transverse incision. Visual analog scale (VAS) was used to evaluate the hypertrophic scar. In transverse incision group, out of five patients, four patients who developed hypertrophic scar have poor score according to VAS. Overall, longitudinal incision should be used for surgical treatment for de Quervain's disease due to lower risk of complications.
Output: Which disease is diagnosed using the Finkelstein's test?
Selenoprotein P is a protein of considerable intrigue, due to its unusual composition and requirements for its biosynthesis. Whereas most selenoproteins contain a single selenocysteine residue, the human, bovine and rodent selenoprotein P genes encode proteins containing 10-12 selenocysteines. Selenoprotein P genes have, to date, only been reported in mammals, and the function of the protein remains elusive. Herein, we report the identification and characterization of nonmammalian selenoprotein P in the zebrafish Danio rerio. Sequencing of the cDNA revealed the presence of 17 selenocysteine codons, the highest number reported in any protein. Two histidine-rich regions present in the mammalian selenoprotein P sequences are conserved in the zebrafish protein, and two SECIS elements are present in the 3' untranslated region. Whole-mount in situ hybridization of zebrafish embryos revealed high levels of expression of selenoprotein P mRNA in fertilized eggs and in the yolk sac of developing embryos. Transient transfection of the cDNA in mammalian cells resulted in efficient expression of the full-length secreted selenoprotein. A single N-glycosylation site is predicted, and shown to be utilized. Discovery of selenoprotein P in the zebrafish opens a previously unavailable avenue for genetic investigation of the functions of this unusual protein.
Output: Which is the human selenoprotein that contains several Se-Cys residues?
It was the last KH-2 Corona' satellite, which was based on an Agena-B. The launch of Discoverer 28 occurred at 00:01 UTC on 4 August 1961.
Output: When was the launch date of Discoverer 28?
Sodium/glucose cotransporter 2 (SGLT2) inhibitors are oral hypoglycemic agents used to treat patients with diabetes mellitus. SGLT2 inhibitors block reabsorption of filtered glucose by inhibiting SGLT2, the primary glucose transporter in the proximal tubular cell (PTC), leading to glycosuria and lowering of serum glucose. We examined the renoprotective effects of the SGLT2 inhibitor empagliflozin to determine whether blocking glucose entry into the kidney PTCs reduced the inflammatory and fibrotic responses of the cell to high glucose. We used an in vitro model of human PTCs. HK2 cells (human kidney PTC line) were exposed to control 5 mM, high glucose (HG) 30 mM or the profibrotic cytokine transforming growth factor beta (TGF1; 0.5 ng/ml) in the presence and absence of empagliflozin for up to 72 h. SGLT1 and 2 expression and various inflammatory/fibrotic markers were assessed. A chromatin immunoprecipitation assay was used to determine the binding of phosphorylated smad3 to the promoter region of the SGLT2 gene. Our data showed that TGF1 but not HG increased SGLT2 expression and this occurred via phosphorylated smad3. HG induced expression of Toll-like receptor-4, increased nuclear deoxyribonucleic acid binding for nuclear factor kappa B (NF-B) and activator protein 1, induced collagen IV expression as well as interleukin-6 secretion all of which were attenuated with empagliflozin. Empagliflozin did not reduce high mobility group box protein 1 induced NF-B suggesting that its effect is specifically related to a reduction in glycotoxicity. SGLT1 and GLUT2 expression was not significantly altered with HG or empagliflozin. In conclusion, empagliflozin reduces HG induced inflammatory and fibrotic markers by blocking glucose transport and did not induce a compensatory increase in SGLT1/GLUT2 expression. Although HG itself does not regulate SGLT2 expression in our model, TGF increases SGLT2 expression through phosphorylated smad3.
Output: Which protein does empagliflozin inhibit?
Samuel McClellan (4 January 1730 -- 17 October 1807) was a Brigadier General in the American Revolutionary War.
Output: What is the war during which Samuel McClellan was in the armed forces?
Ion Assault is a multidirectional shooter video game developed by Coreplay and published by Black Inc. for the Xbox Live Arcade, PlayStation Network, and Microsoft Windows.
Output: Who worked on Ion Assault?
Facioscapulohumeral muscular dystrophy (FSHD) is a slowly progressive myopathy with autosomal dominant inheritance remarkable for its early involvement of facial musculature. The purpose of our study was to assess the rate of strength deterioration, functional condition and performance of activity of daily living of patients with FSHD in Taiwan. Twenty patients diagnosed with FSHD were included in this study. Manual muscle testing (MMT) was used to evaluate muscle strength. The Brooke and Vignos scales were used to assess upper and lower extremity function respectively, and the capability of the activity of daily living was measured by Barthel index. The result of the strength testing was characterized by the presence of a progressive asymmetrical muscular weakness in patients with FSHD. The mean muscular strength of the right extremity was weaker than its left counterparts (p < 0.05) and the shoulder muscle group was the weakest. According to the Brooke functional scale, 20% of our patients were graded as 1, 30% as grade 2, and 50% as grade 3. On the Vignos functional scale, 50% of patients fell into grade 1, 10% in grade 2, and 40% in grades 3-5. Vignos scale was significantly correlated with mean muscle strength (p < 0.05). The average value of Barthel index was 97.8 +/- 4.7. The muscle strength decline in this Taiwanese of FSHD population was more severe in shoulder girdle area. The mean muscle strength of the right extremity was weaker than the left. Most of our patients suffered from mild or moderate physical disability. Finding of these Taiwanese FSHD population is similar to those reported elsewhere in the world.
Output: What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?
The IUCN, however, ranks the Canada warbler as a species of least concern.
Output: What is the status of Canada warbler?
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, which causes progressive and eventually fatal loss of motor function. Here, we describe genetic and pathologic characterization of brain tissue banked from 19 ALS patients over nearly 20years at the Department of Anatomy and the Centre for Brain Research, University of Auckland, New Zealand. We screened for mutations in SOD1, TARDBP, FUS, and C9ORF72 genes and for neuropathology caused by phosphorylated TDP-43, dipeptide repeats (DPRs), and ubiquilin. We identified 2 cases with C9ORF72 repeat expansions. Both harbored phosphorylated TDP-43 and DPR inclusions. We show that DPR inclusions can incorporate or occur independently of ubiquilin. We also identified 1 case with a UBQLN2 mutation, which showed phosphorylated TDP-43 and characteristic ubiquilin protein inclusions. This is the first study of ALS genetics in New Zealand, adding New Zealand to the growing list of countries in which C9ORF72 repeat expansion and UBQLN2 mutations are detected in ALS cases.
Output: Which human disease is associated with mutated UBQLN2
The Deepwater Horizon oil spill (also referred to as the BP oil spill, the BP oil disaster, the Gulf of Mexico oil spill, and the Macondo blowout) began on 20 April 2010 in the Gulf of Mexico on the BP-operated Macondo Prospect.
Output: What year did Deepwater Horizon oil spill start?
Our objective was to evaluate the diagnostic value of computed tomography angiography (CTA) and ventilation perfusion (V/Q) scan in the assessment of pulmonary embolism (PE) by means of a Bayesian statistical model. Wells criteria defined pretest probability. Sensitivity and specificity of CTA and V/Q scan for PE were derived from pooled meta-analysis data. Likelihood ratios calculated for CTA and V/Q were inserted in the nomogram. Absolute (ADG) and relative diagnostic gains (RDG) were analyzed comparing post- and pretest probability. Comparative gain difference was calculated for CTA ADG over V/Q scan integrating ANOVA p value set at 0.05. The sensitivity for CT was 86.0% (95% CI: 80.2%, 92.1%) and specificity of 93.7% (95% CI: 91.1%, 96.3%). The V/Q scan yielded a sensitivity of 96% (95% CI: 95%, 97%) and a specificity of 97% (95% CI: 96%, 98%). Bayes nomogram results for CTA were low risk and yielded a posttest probability of 71.1%, an ADG of 56.1%, and an RDG of 374%, moderate-risk posttest probability was 85.1%, an ADG of 56.1%, and an RDG of 193.4%, and high-risk posttest probability was 95.2%, an ADG of 36.2%, and an RDG of 61.35%. The comparative gain difference for low-risk population was 46.1%; in moderate-risk 41.6%; and in high-risk a 22.1% superiority. ANOVA analysis for LR+ and LR- showed no significant difference (p=0.8745, p=0.9841 respectively). This Bayesian model demonstrated a superiority of CTA when compared to V/Q scan for the diagnosis of pulmonary embolism. Low-risk patients are recognized to have a superior overall comparative gain favoring CTA.
Output: What can be predicted with the Wells criteria?
Mutations in the human FOXP2 gene cause speech and language impairments. The FOXP2 protein is a transcription factor that regulates the expression of many downstream genes, which may have important roles in nervous system development and function. An adequate amount of functional FOXP2 protein is thought to be critical for the proper development of the neural circuitry underlying speech and language. However, how FOXP2 gene expression is regulated is not clearly understood. The FOXP2 mRNA has an approximately 4-kb-long 3' untranslated region (3' UTR), twice as long as its protein coding region, indicating that FOXP2 can be regulated by microRNAs (miRNAs). We identified multiple miRNAs that regulate the expression of the human FOXP2 gene using sequence analysis and in vitro cell systems. Focusing on let-7a, miR-9, and miR-129-5p, three brain-enriched miRNAs, we show that these miRNAs regulate human FOXP2 expression in a dosage-dependent manner and target specific sequences in the FOXP2 3' UTR. We further show that these three miRNAs are expressed in the cerebellum of the human fetal brain, where FOXP2 is known to be expressed. Our results reveal novel regulatory functions of the human FOXP2 3' UTR sequence and regulatory interactions between multiple miRNAs and the human FOXP2 gene. The expression of let-7a, miR-9, and miR-129-5p in the human fetal cerebellum is consistent with their roles in regulating FOXP2 expression during early cerebellum development. These results suggest that various genetic and environmental factors may contribute to speech and language development and related neural developmental disorders via the miRNA-FOXP2 regulatory network.
Output: Which gene is responsible for proper speech development?
Michael Jackson is one of the world's best singers. Michael Jackson was born in the middle west of the city of Gary, Indiana, in 1958. He began singing with his four brothers. They called the group "The Jackson Five". The group became very popular after appearing on a television program. They started singing in 1965, and became popular soon. In 1970 the group made their first record with the name of "I Want You Back". It was very popular. One of their hit records was "Never Say Goodbye". Michael was good at dancing as well as singing, such as his dance moves and moon walking. He was asked to act in a film in 1978 for the first time, and in the same year he made a record on his own, which sold eight million _ all over the world. Michael nearly didn't go out because he was too famous. Once his fans went off in a faint when they saw him at the concert. No one can do it by now. He lived in a large house and kept lots of animals. He never ate meat. He often raised money for Charity. This made him win the Guinness World Records in 2006. He died on June 25th, 2009, but he would live in our heart forever.
Output: What's the name of their first record?
To compare tumor control rates after surgical resection or stereotactic radiosurgery for patients with small- to medium-size intracranial meningiomas. Between 1990 and 1997, 198 adult meningioma patients treated at our center underwent either surgical resection (n = 136) or radiosurgery (n = 62) as primary management for benign meningiomas <35 mm in average diameter. Tumor recurrence or progression rates were calculated by the Kaplan-Meier method according to an independent radiographic review. The mean follow-up was 64 months. The tumor resections were Simpson Grade 1 in 57 (42%), Grade 2 in 57 (42%), and Grade 3-4 in 22 (16%). The mean margin and maximal radiation dose at radiosurgery was 17.7 Gy and 34.9 Gy, respectively. Tumor recurrence/progression was more frequent in the surgical resection group (12%) than in the radiosurgical group (2%; p = 0.04). No statistically significant difference was detected in the 3- and 7-year actuarial progression-free survival (PFS) rate between patients with Simpson Grade 1 resections (100% and 96%, respectively) and patients who underwent radiosurgery (100% and 95%, respectively; p = 0.94). Radiosurgery provided a higher PFS rate compared with patients with Simpson Grade 2 (3- and 7-year PFS rate, 91% and 82%, respectively; p <0.05) and Grade 3-4 (3- and 7-year PFS rate, 68% and 34%, respectively; p <0.001) resections. Subsequent tumor treatments were more common after surgical resection (15% vs. 3%, p = 0.02). Complications occurred in 10% of patients after radiosurgery compared with 22% of patients after surgical resection (p = 0.06). The PFS rate after radiosurgery was equivalent to that after resection of a Simpson Grade 1 tumor and was superior to Grade 2 and 3-4 resections in our study. If long-term follow-up confirms the high tumor control rate and low morbidity of radiosurgery, this technique will likely become the preferred treatment for most patients with small- to moderate-size meningiomas without symptomatic mass effect.
Output: Simpson grading is used to describe resection of which brain tumor?
Spleen tyrosine kinase (Syk) is involved in the development of the adaptive immune system and has been recognized as being important in the function of additional cell types, including platelets, phagocytes, fibroblasts, and osteoclasts, and in the generation of the inflammasome. Preclinical studies presented compelling evidence that Syk inhibition may have therapeutic value in the treatment of rheumatoid arthritis and other forms of arthritis, systemic lupus erythematosus, autoimmune cytopenias, and allergic and autoinflammatory diseases. In addition, Syk inhibition may have a place in limiting tissue injury associated with organ transplant and revascularization procedures. Clinical trials have documented exciting success in the treatment of patients with rheumatoid arthritis, autoimmune cytopenias, and allergic rhinitis. While the extent and severity of side effects appear to be limited so far, larger studies will unravel the risk involved with the clinical benefit.
Output: Which enzyme is inhibited by a drug fostamatinib?
During active transport, molecules move from an area of low concentration to an area of high concentration. This is the opposite of diffusion, and these molecules are said to flow against their concentration gradient. Active transport is called "active" because this type of transport requires energy to move molecules. ATP is the most common source of energy for active transport. As molecules are moving against their concentration gradients, active transport cannot occur without assistance. A carrier protein is always required in this process. Like facilitated diffusion, a protein in the membrane carries the molecules across the membrane, except this protein moves the molecules from a low concentration to a high concentration. These proteins are often called "pumps" because they use energy to pump the molecules across the membrane. There are many cells in your body that use pumps to move molecules. For example, your nerve cells (neurons) would not send messages to your brain unless you had protein pumps moving molecules by active transport. The sodium-potassium pump ( Figure 1.1) is an example of an active transport pump. The sodium-potassium pump uses ATP to move three sodium (Na+ ) ions and two potassium (K+ ) ions to where they are already highly concentrated. Sodium ions move out of the cell, and potassium ions move into the cell. How do these ions then return to their original positions? As the ions now can flow down their concentration gradients, facilitated diffusion returns the ions to their original positions either inside or outside the cell.
Output: complete the following sentence. as molecules are moving against their concentration gradients, active transport cannot occur without __________.
Inherited ventricular arrhythmias such as the long QT syndrome (LQTS), Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia (CPVT), idiopathic ventricular fibrillation (VF), and arrhythmogenic right ventricular cardiomyopathy (ARVC) account for a relevant proportion of sudden cardiac death cases in young patients cohorts. The detailed pathogenetic mechanisms of inherited ventricular arrhythmias are still poorly understood because systematic investigations are difficult to perform due to low patient numbers and the lack of appropriate experimental models. However, recent advances in research and science have identified a genetic background for many of these diseases. In LQTS, various mutations in different genes encoding for cardiac potassium and sodium channel proteins have been identified ("channelopathy"), and initial progress in genotype-phenotype correlation is made. Mutations in the cardiac sodium channel gene have also been identified in a subset of patients with Brugada syndrome, whereas a genetic background has not yet been demonstrated in idiopathic VF and right ventricular outflow-tract tachycardia (RVO-VT). Very recently, mutations in the cardiac ryanodine receptor gene have been identified in CPVT and in a subgroup of patients with ARVC. Although several chromosomal loci were suggested, no other responsible genes or mutations have been found in autosomal dominant forms of ARVC. However, in Naxos disease, a recessive form of ARVC with coexpression of palmoplantar keratoderma and woolly hair, a mutation in the plakoglobin gene has recently been discovered, thus underscoring the potential role of genetic alterations in cytoskeletal proteins in ARVC. In the next years, significant progress in the genetic diagnosis pathophysiologic understanding of disease mechanisms, genotype-phenotype correlation, and the development of gene- or target-directed treatment strategies can be expected in the field of inherited ventricular arrhythmias. This review summarizes the current knowledge of the molecular mechanisms, including aspects of pathoanatomy, autonomic innervation, genetics, and genotype-phenotype correlations with their potential implications for diagnosis and treatment of inherited ventricular arrhythmias.
Output: Which gene is mutated in a subtype of arrhythmogenic right ventricular cardiomyopathy known as Naxos disease?
There have been several milestones in the Paralympic movement. The first official Paralympic Games, no longer open solely to war veterans, was held in Rome in 1960 Summer Paralympics. 400 athletes from 23 countries competed at the 1960 Games. Since 1960, the Paralympic Games have taken place in the same year as the Olympic Games. The Games were initially open only to athletes in wheelchairs; at the 1976 Summer Paralympics, athletes with different disabilities were included for the first time at a Summer Paralympics. With the inclusion of more disability classifications the 1976 Summer Games expanded to 1,600 athletes from 40 countries. The 1988 Summer Paralympics in Seoul, South Korea, was another milestone for the Paralympic movement. It was in Seoul that the Paralympic Summer Games were held directly after the 1988 Summer Olympics, in the same host city, and using the same facilities. This set a precedent that was followed in 1992 Summer Paralympics, 1996 Summer Paralympics and 2000 Summer Paralympics. It was eventually formalized in an agreement between the International Paralympic Committee (IPC) and the International Olympic Committee (IOC) in 2001, and was extended through 2020. On March 10, 2018, the two committees further extended their contract to 2032. The 1992 Winter Paralympics were the first Winter Games to use the same facilities as the 1992 Winter Olympics.
Output: Originally, participation in the Paralympic Games was limited to which group?
Pyerun Patera is a patera, or a complex crater with scalloped edges, on Jupiter's moon Io.
Output: What is the astronomical body that Pyerun Patera is located on?
Transcription-coupled repair (TCR) is the major pathway involved in the removal of UV-induced photolesions from the transcribed strand of active genes. Two Cockayne syndrome (CS) complementation group proteins, CSA and CSB, are important for TCR repair. The molecular mechanisms by which CS proteins regulate TCR remain elusive. Here, we report the characterization of KIAA1530, an evolutionarily conserved protein that participates in this pathway through its interaction with CSA and the TFIIH complex. We found that UV irradiation led to the recruitment of KIAA1530 onto chromatin in a CSA-dependent manner. Cells lacking KIAA1530 were highly sensitive to UV irradiation and displayed deficiency in TCR. In addition, KIAA1530 depletion abrogated stability of the CSB protein following UV irradiation. More excitingly, we found that a unique CSA mutant (W361C), which was previously identified in a patient with UV(s)S syndrome, showed defective KIAA1530 binding and resulted in a failure of recruiting KIAA1530 and stabilizing CSB after UV treatment. Together, our data not only reveal that KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
The Chevrolet Equinox is a mid-size crossover SUV from Chevrolet based on General Motors's Theta unibody platform, manufactured at CAMI Automotive (formerly a GM/Suzuki joint venture, now wholly owned by GM) plant in Ingersoll, Ontario, Canada, and introduced in 2004 for the 2005 model year.
Output: Which company manufactured Chevrolet Equinox?
Suppression subtractive hybridization performed on Down syndrome (DS) versus control fetal brains revealed differential expression of peroxiredoxin 2 (PRDX2), mapped at 13q12. Peroxiredoxins are antioxidant enzymes involved in protein and lipid protection against oxidative injury and in cellular signalling pathways regulating apoptosis. The under-expression of PRDX2 observed in DS samples was confirmed by real-time PCR (0.73-fold). To test whether decreased expression is associated with enhanced sensitivity of DS neurons to reactive oxygen species, we down-regulated PRDX2 through stable transfections of SH-SY5Y neuroblastoma cells with antisense contructs of the complete PRDX2 coding sequence. In addition, we over-expressed SOD1 and compared the effects of the two genes on cell viability. Cells transfected with either construct showed similar sensitivity to oxidative stress in addition to increased apoptosis under basal conditions and after treatment with oxidative cytotoxic agents. This suggests that the decreased expression of PRDX2 may contribute to the altered redox state in DS at levels comparable to that of the increased expression of SOD1.
Output: What type of enzyme is peroxiredoxin 2 (PRDX2)?
Johann Bayer used the Greek letters Alpha to Eta to label the most prominent eight stars in the constellation, designating two stars as Delta (named Delta1 and Delta2). John Flamsteed numbered fourteen stars, discerning a third star he named Delta3; his star 12 Canis Minoris was not found subsequently. In Bayers 1603 work Uranometria, Procyon is located on the dogs belly, and Gomeisa on its neck. Gamma Canis Minoris, Epsilon Canis Minoris and Eta Canis Minoris lie nearby, marking the dogs neck, crown and chest respectively. Although it has an apparent magnitude of 4.34, Gamma Canis Minoris is an orange stellar classification giant star of spectral class K3-III C, which lies away. Its colour is obvious when seen through binoculars. It is a multiple system, consisting of the spectroscopic binary Gamma A and three optical companions, Gamma B, magnitude 13; Gamma C, magnitude 12; and Gamma D, magnitude 10. The two components of Gamma A orbit each other every 389.2 days, with an eccentric orbit that takes their separation between 2.3 and 1.4 astronomical units (AU). Epsilon Canis Minoris is a yellow bright giant of spectral class G6.5IIb of magnitude of 4.99. It lies from Earth, with 13 times the diameter and 750 times the luminosity of the Sun. Eta Canis Minoris is a giant of spectral class F0III of magnitude 5.24, which has a yellowish hue when viewed through binoculars as well as a faint companion of magnitude 11.1. Located 4 arcseconds from the primary, the companion star is actually around 440 AU from the main star and takes around 5000 years to orbit it.
Output: Who labeled more starts, Johann Bayer or John Flamsteed?
Insulin is the cornerstone of type 1 diabetes mellitus (T1DM) therapy. However, it cannot achieve a delay in the onset or evolution of this condition, while cardiovascular morbidity remains an unquestionable threat. In this review, the authors discuss gevokizumab (XOMA 052), a recombinant monoclonal antibody that can neutralize human IL-1 by binding to it. This is relevant, because this IL has been associated with -cell toxicity in both diabetes types. Moreover, gevokizumab presents two major advantages: it spares IL-1 and it exhibits favorable pharmacokinetic properties. Gevokizumab has already proven its safety and efficacy in improving glycemic control, cell function and inflammation markers in clinical trials in diabetic patients. Despite the very promising characteristics of gevokizumab, important questions remain to be answered. One important question is what to expect from a combination of this agent with insulin and if there is a subset of patients that might respond more favorably to treatment. We also need to know at what stage in the natural history of T1DM could gevokizumab be most efficacious, as well as its potential effects on cardiovascular outcomes.
Output: Which molecule is targeted by the drug Gevokizumab?
Drosophila melanogaster has a single Adar gene encoding a protein related to mammalian ADAR2 that edits transcripts encoding glutamate receptor subunits. We describe the structure of the Drosophila Adar locus and use ModENCODE information to supplement published data on Adar gene transcription, and splicing. We discuss the roles of ADAR in Drosophila in terms of the two main types of RNA molecules edited and roles of ADARs as RNA-binding proteins. Site-specific RNA editing events in transcripts encoding ion channel subunits were initially found serendipitously and subsequent directed searches for editing sites and transcriptome sequencing have now led to 972 edited sites being identified in 597 transcripts. Four percent of D. melanogaster transcripts are site-specifically edited and these encode a wide range of largely membrane-associated proteins expressed particularly in CNS. Electrophysiological studies on the effects of specific RNA editing events on ion channel subunits do not suggest that loss of RNA editing events in ion channels consistently produce a particular outcome such as making Adar mutant neurons more excitable. This possibility would have been consistent with neurodegeneration seen in Adar mutant fly brains. A further set of ADAR targets are dsRNA intermediates in siRNA generation, derived from transposons and from structured RNA loci. Transcripts with convergent overlapping 3' ends are also edited and the first discovered instance of RNA editing in Drosophila, in the Rnp4F transcript, is an example. There is no evidence yet to show that Adar antagonizes RNA interference in Drosophila. Evidence has been obtained that catalytically inactive ADAR proteins exert effects on microRNA generation and RNA interference. Whether all effects of inactive ADARs are due to RNA-binding or to even further roles of these proteins remains to be determined.
Output: Which is the major RNA editing enzyme in Drosophila melanogaster?
The TK (also known as the TK-3) tankette was a Polish design produced from 1931 based on the chassis of the British Carden Loyd tankette, with an improved hull and more powerful engine, and armour up to 8 mm thick (10 mm on the TKS).
Output: What year was the service entry date for TKS?
Selenoprotein S (SelS) is a 189 amino acid trans-membrane protein that plays an important yet undefined role in the unfolded protein response. It has been proposed that SelS may function as a reductase, with the penultimate selenocysteine (Sec(188)) residue participating in a selenosulfide bond with cysteine (Cys(174)). Cotranslational incorporation of Sec into SelS depends on the recoding of the UGA codon, which requires a Selenocysteine Insertion Sequence (SECIS) element in the 3'UTR of the transcript. Here we identify multiple mechanisms that regulate the expression of SelS. The human SelS gene encodes two transcripts (variants 1 and 2), which differ in their 3'UTR sequences due to an alternative splicing event that removes the SECIS element from the variant 1 transcript. Both transcripts are widely expressed in human cell lines, with the SECIS-containing variant 2 mRNA being more abundant. In vitro experiments demonstrate that the variant 1 3'UTR does not allow readthrough of the UGA/Sec codon. Thus, this transcript would produce a truncated protein that does not contain Sec and cannot make the selenosulfide bond. While the variant 2 3'UTR does support Sec insertion, its activity is weak. Bioinformatic analysis revealed two highly conserved stem-loop structures, one in the proximal part of the variant 2 3'UTR and the other immediately downstream of the SECIS element. The proximal stem-loop promotes Sec insertion in the native context but not when positioned far from the UGA/Sec codon in a heterologous mRNA. In contrast, the 140 nucleotides downstream of the SECIS element inhibit Sec insertion. We also show that endogenous SelS is enriched at perinuclear speckles, in addition to its known localization in the endoplasmic reticulum. Our results suggest the expression of endogenous SelS is more complex than previously appreciated, which has implications for past and future studies on the function of this protein.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Producing money requires both artistic and technological skills. Dollar bills are made so that they are interesting to look at but very hard to copy. In total, there are sixty-five separate steps required to make a dollar bill. The money making process begins when. a yearly order is sent by the Federal Reserve Board. That order will then be divided in half. Half will be done here in Washington, D. C.and the other half will be done in Fort Worth, Texas. Next, the Bureau orders special paper which is actually cloth since it is 75% cotton and 25% linen. This paper is made so that it can last a long time. And, it is made with details that make it hard to copy. For example, bills contain security threads. These narrow pieces of plastic are inside the paper and run along the width of the bill. This special paper is also made with very small blue and red fibers. Once the money is printed, guillotine cutters separate the sheets into two notes, then into individual notes. The notes are organized in "bricks," each of which contains forty one-hundred-note packages. The bricks then go to one of twelve Federal Reserve Districts, which then give the money to local banks. Ninety-five percent of the bills printed each year are used to replace money that is in circulation, or that has already been removed from circulation. You may know that America's first president, George Washington, is pictured on the one- dollar bill. But do you know whose face is on the two, five, ten, twenty, fifty and one hundred-dollar bills? They are, in order. President Thomas Jefferson, President Abraham Lincoln, Treasury Secretary Alexander Hamilton, President Andrew Jackson, President Ulysses Grant and statesman Benjamin Franklin. The average life span of a one-dollar bill is twenty-one months. But a ten-dollar bill lasts only about eighteen months. The one hundred-dollar bill lasts the longest, eighty-nine months. One popular question is about the two-dollar bill. This bill is not printed very often. This is because many Americans believe two-dollar bills are lucky, so they keep them.
Output: How many presidents are printed on the American money?
If you want to become a fluent English speaker you should take some advice: There are four skills in learning English. They are reading, listening, speaking, and writing. The most important thing you must remember is that if you want to improve your speaking and writing skills you should first master the skills of reading and listening. Read as much as you can. But your reading must be active. It means that you must think about the meaning of the sentence, the meanings of the unfamiliar words, etc. There is no need for you to pay much attention to grammars or try to understand all the unfamiliar words you _ , but the fact that you see them for the first time and recognize them whenever you see them, for example in other passages or books, is enough. It would be better to prepare yourself a notebook so you can write down the important words or sentences in it. As for listening, there are two choices: besides reading, you can listen every day for about 30 minutes. You can only pay attention to your reading and become skillful at your reading, then you can catch up on your listening. Since you have lots of inputs in your mind, you can easily guess what the speaker is going to say. This never means that you should not practice listening. For listening you can listen to cartoons or some movies that are specially made for children. Their languages are easy. Or if you are good at listening you can listen to VOA or BBC programs every day. Again the thing to remember is being active in listening and preferably taking some notes. If you follow these pieces of advice, your speaking and writing will improve automatically, and you can be sure that with a little effort they will become perfect.
Output: According to the author, which should you improve first among the four skills?
Mamadou Sidibe is a Malian professional footballer, who plays as a midfielder for AS Police de Bamako.
Output: Which player position does Mamadou Sidibé belong to?