niryuu/sni-each-converted huggingface dataset:
The natively disordered protein alpha-synuclein is the primary component of Lewy bodies, the cellular hallmark of Parkinson's disease. Most studies of this protein are performed in dilute solution, but its biologically relevant role is performed in the crowded environment inside cells. We addressed the effects of macromolecular crowding on alpha-synuclein by combining NMR data acquired in living Escherichia coli with in vitro NMR data. The crowded environment in the E.coli periplasm prevents a conformational change that is detected at 35 degrees C in dilute solution. This change is associated with an increase in hydrodynamic radius and the formation of secondary structure in the N-terminal 100 amino acid residues. By preventing this temperature-induced conformational change, crowding in the E.coli periplasm stabilizes the disordered monomer. We obtain the same stabilization in vitro upon crowding alpha-synuclein with 300 g/l of bovine serum albumin, indicating that crowding alone is sufficient to stabilize the disordered, monomeric protein. Two disease-associated variants (A30P and A53T) behave in the same way in both dilute solution and in the E.coli periplasm. These data reveal the importance of approaching the effects of macromolecular crowding on a case-by-case basis. Additionally, our work shows that discrete structured protein conformations may not be achieved by alpha-synuclein inside cells, implicating the commonly overlooked aspect of macromolecular crowding as a possible factor in the etiology of Parkinson's disease.
Output: Which is the primary protein component of Lewy bodies?
The Rights of the Terminally Ill Act 1995 (NT) was a controversial law legalising euthanasia, passed by the Legislative Assembly of the Northern Territory of Australia in 1995, but effectively nullified in 1997 by the Federal Parliament.
Output: On what date did Rights of the Terminally Ill Act 1995 end?
Rolland-Pilain was a French car maker formally established on 4 November 1905 at 95, rue Victor-Hugo in Tours by Francois Rolland and Emile Pilain.
Output: Which year witnessed the formation of Rolland-Pilain?
GATA-1 and the ets factor PU.1 have been reported to functionally antagonize one another in the regulation of erythroid versus myeloid gene transcription and development. The CCAAT enhancer binding protein epsilon (C/EBPepsilon) is expressed as multiple isoforms and has been shown to be essential to myeloid (granulocyte) terminal differentiation. We have defined a novel synergistic, as opposed to antagonistic, combinatorial interaction between GATA-1 and PU.1, and a unique repressor role for certain C/EBPepsilon isoforms in the transcriptional regulation of a model eosinophil granulocyte gene, the major basic protein (MBP). The eosinophil-specific P2 promoter of the MBP gene contains GATA-1, C/EBP, and PU.1 consensus sites that bind these factors in nuclear extracts of the eosinophil myelocyte cell line, AML14.3D10. The promoter is transactivated by GATA-1 alone but is synergistically transactivated by low levels of PU.1 in the context of optimal levels of GATA-1. The C/EBPepsilon(27) isoform strongly represses GATA-1 activity and completely blocks GATA-1/PU.1 synergy. In vitro mutational analyses of the MBP-P2 promoter showed that both the GATA-1/PU.1 synergy, and repressor activity of C/EBPepsilon(27) are mediated via protein-protein interactions through the C/EBP and/or GATA-binding sites but not the PU.1 sites. Co-immunoprecipitations using lysates of AML14.3D10 eosinophils show that both C/EBPepsilon(32/30) and epsilon(27) physically interact in vivo with PU.1 and GATA-1, demonstrating functional interactions among these factors in eosinophil progenitors. Our findings identify novel combinatorial protein-protein interactions for GATA-1, PU.1, and C/EBPepsilon isoforms in eosinophil gene transcription that include GATA-1/PU.1 synergy and repressor activity for C/EBPepsilon(27).
Output: Which gene controls the expression of GATA-1 isoforms?
As a student leader at George Washington University in the 1970s, Mowahid Shah was Editor of the ''Harbinger'', a student publication.
Output: What college did Mowahid Shah go to?
Deletions of the proximal long arm of chromosome 15 (bands 15q11q13) are found in the majority of patients with two distinct genetic disorders, Angelman syndrome (AS) and Prader-Willi syndrome (PWS). The deleted regions in the two syndromes, defined cytogenetically and by using cloned DNA probes, are similar. However, deletions in AS occur on the maternally inherited chromosome 15, and deletions in PWS occur on the paternally derived chromosome 15. This observation has led to the suggestion that one or more genes in this region show differential expression dependent on parental origin (genetic imprinting). No genes of known function have previously been mapped to this region. We show here that the gene encoding the GABAA (gamma-aminobutyric acid) receptor beta 3 subunit maps to the AS/PWS region. Deletion of this gene (GABRB3) was found in AS and PWS patients with interstitial cytogenetic deletions. Evidence of beta 3 gene deletion was also found in an AS patient with an unbalanced 13;15 translocation but not in a PWS patient with an unbalanced 9;15 translocation. The localization of this receptor gene to the AS/PWS region suggests a possible role of the inhibitory neurotransmitter GABA in the pathogenesis of one or both of these syndromes.
Output: Angelman syndrome is associated with deletion of a part of Chromosome 15 but if the deletion occurs in the paternally inherited chromosome 15, what is the disease?
Luther Skaggs, Jr. died on April 6, 1976 and was buried in Arlington National Cemetery with full military honors.
Output: What cemetery is Luther Skaggs, Jr. buried in?
Banketten (English: The Banquet) is a 1948 Swedish drama film directed by Hasse Ekman.
Output: Who was the director of Banketten?
Darma (Pierre Andre) is traumatised by the mysterious death of his fiancee, Rose (Intan Ladyana) who had killed herself. Unknown to him, Rose had been haunted by a malicious spirit which they had brought to her home after picking up a small jar found washed up at the beach. Apparently, the spirit had been imprisoned and was inadvertently released by the couple.At her home, after her death, before leaving Darma had taken the small jar with him, and with it, the malignant spirit.Not satisfied with why Rose had suddenly killed herself, Darma decides to investigate the case with the help of Rose's twin sister, Seri, (also played by Intan Ladyana). As they probe into the death, a series of strange occurrences start to unravel, leaving Darma in a disturbed state of mind that affects his life and career. When he is advised to take a week's break from work, he returns to his village to rest. Unknown to him, he is only getting closer to solving his fiancee's death and the truth behind the strange happenings.It was Darma's senile grandmother who could see the ghost and had unwittingly invited the spirit into the house. In Malay belief, certain spirits cannot enter the house unless invited in. This is similar to the vampire mythology in the West. The ghost in this movie is called Saka. Saka was a ghost that has been kept by the elder for some uncertified reason. Mostly, Saka starts to give problems when it's owner die and Saka needs to be feed. Mostly, Saka will haunt the next generation of the owner.
Output: What is Darma advised to take from work?
This March is a busy month in Shanghai.There's a lot to do.Here are the highlights. Live Music - Late Night Jazz Enjoy real American jazz from Herbie Davis, the famous trumpet player.He's coming with his new 7-piece band, Herbie's Heroes.Herbie is known to play well into the early hours, so don't expect to get much sleep.This is Herbie's third visit to Shanghai.The first two were sold out, so get your tickets quickly. PLACE: The Jazz Club DATES: 15---23 March PRICE: Y=80,120 TIME: 10:00p.m.till late! TEL: 6466--8736 Scottish dancing Take your partners and get ready to dance till you drop.Scottish dancing is fun and easy to learn.Instructors will demonstrate the dances.The live band, Gordon Stroppie and the Weefrees, are also excellent. PLACE: Jack Stein's DATES: every Monday PRICE: Y60 including one drink TIME: 7:00 ---0:00 p.m. TEL: 6402-1877 Exhibitions - Shanghai Museum There are 120,000 pieces on show here.You can see the whole of Chinese history under one roof.It's always interesting to visit, but doubly so at the moment with the Egyptian Tombs exhibition.There are lots of mummies and more gold than you've ever seen before.Let us know if you see a mummy move! PLACE: Shanghai Museum PRICE: Y=30 (Y= 15 for students) TEL: 6888-6888 DATES: daily TIME: Monday - Friday 9:00a.m.- 5:00p.m., Weekends 9:00a.m.--- 9:00p.m. Dining - Sushi chef in town Sushi is getting really big in Shanghai.In Japan, it's become an art form.The most famous Sushi 'artist' is Yuki Kamura.She's also one of the few female chefs in Japan.She'll be at Sushi Scene all of this month. PLACE: Sushi Scene in the Shanghai Hotel DATES: all month PRICE: Y=200 TIME: lunchtime TEL: 6690-3211 For a full listing of events, see our website.
Output: Suppose you are going to attend an activity at 8: 00p.m.on Saturday, which one can   you choose?
Finkelstein's test is the classic diagnostic test for de Quervain's disease. Finkelstein hypothesized that the entry of the muscle bellies of the extensor pollicis brevis (EPB) and abductor pollicis longus (APL) tendons into the first extensor compartment was responsible for the findings observed in his now eponymous test. We agree with Finkelstein's hypothesis and further hypothesize that this position would induce measurable bulk (muscle mass within the retinaculum) and tethering (stretching of synovial tissue) effects within the compartment. To test this latter hypothesis we measured the excursion and gliding resistance of the EPB and APL tendons within the first compartment. Fifteen fresh-frozen cadavers were used. Gliding resistance and excursion were measured in 4 different wrist positions, including the wrist position of Finkelstein's test (30 degrees ulnar deviation). The bulk and tethering effect was calculated based on the mean gliding resistance over the tendon proximal/distal excursion cycle and the gliding resistance at the terminal distal excursion. The EPB tendon excursion was significantly more distal in 30 degrees ulnar deviation than in 60 degrees extension. Additionally the bulk and tethering resistance was significantly greater in 30 degrees ulnar deviation compared with 60 degrees extension. For the APL tendon there was no significant difference in either the tendon excursion or the bulk and tethering resistance between 30 degrees ulnar deviation and 60 degrees extension. We showed that in the position of Finkelstein's test the EPB tendon is significantly more distal and has significantly greater bulk and tethering effect compared with the other EPB positions. This is not the case for the APL tendon in the position of Finkelstein's test. These results suggest that an abnormal Finkelstein's test reflects differences of the EPB more than it does the APL.
Output: Which disease is diagnosed using the Finkelstein's test?
In his works, the Gladden Fields are located where the Gladden river joins the Anduin.
Output: What body of water was Gladden Fields next to?
Cluj-Napoca experienced a decade of decline during the 1990s, its international reputation suffering from the policies of its mayor at the time, Gheorghe Funar.
Output: Who became the leader of Cluj-Napoca?
Lack of the yeast Rrm3p DNA helicase causes replication defects at multiple sites within ribosomal DNA (rDNA), including at the replication fork barrier (RFB). These defects were unaltered in rrm3 sir2 cells. When the RFB binding Fob1p was deleted, rrm3-generated defects at the RFB were eliminated, but defects at other rDNA sites were not affected. Thus, specific protein-DNA complexes make replication Rrm3p-dependent. Because rrm3-induced increases in recombination and cell cycle length were only partially suppressed in rrm3 fob1 cells, which still required checkpoint and fork restart activities for viability, non-RFB rrm3-induced defects contribute to rDNA fragility and genome instability.
Output: What is the effect of the absence of Saccharomyces cerevisiae Rrm3p?
The Kaiser Shipyards were seven major shipbuilding yards located on the U.S. west coast during World War II. Kaiser ranked 20th among United States corporations in the value of wartime production contracts.
Output: Which industry is Kaiser Shipyards associated with?
Angyali udvozlet, aka "The Annunciation", is a surreal account of the history of humanity as portrayed entirely by children between the ages of 8 and 12. The film begins with the biblical story as Adam (Peter Bocsor) and Eve (Julia Mero), are deceived by Lucifer (Eszter Gyalog) -- three very photogenic leads -- into tasting the "Forbidden Fruit". They are thus chased out of the Garden of Eden by the Angel of Death and, in a vision, sent on an existential journey through western European history.Always followed closely and influenced by the deceptively sweet, but contemptuous Lucifer, we follow Adam through The Plague, wars, Byzantium's wretched cripples, the French Revolution, the squalor of Dickensian London, and a final return to the scene of the crucifixion. Of course the picture makes a case for its premise -- that of the consequences of Original Sin -- yet does so in a very unique way. In the closing scene, Lucifer says, "Why did I strive to achieve greatness in man, who is...in knowlege a pygmy, in blindness a giant?" This reflects the somewhat nihilistic view of a nation still under the boot of Soviet communism.This rare movie may be one of the best (and only child-starred) art films ever.
Output: Who holds Lucifer to his promise?
For regulatory approval, consistency in manufacturing of vaccine lots is expected to be demonstrated in confirmatory immunogenicity studies using two-sided equivalence trials. This randomized, double-blind study (NCT01323972) assessed consistency of three RTS,S/AS01 malaria vaccine batches formulated from commercial-scale purified antigen bulk lots in terms of anti-CS-responses induced. Healthy children aged 5-17 months were randomized (1:1:1:1) to receive RTS,S/AS01 at 0-1-2 months from one of three commercial-scale purified antigen bulk lots (1600 litres-fermentation scale; commercial-scale lots), or a comparator vaccine batch made from pilot-scale purified antigen bulk lot (20 litres-fermentation scale; pilot-scale lot). The co-primary objectives were to first demonstrate consistency of antibody responses against circumsporozoite (CS) protein at one month post-dose 3 for the three commercial-scale lots and second demonstrate non-inferiority of anti-CS antibody responses at one month post-dose 3 for the commercial-scale lots compared to the pilot-scale lot. Safety and reactogenicity were evaluated as secondary endpoints. One month post-dose-3, anti-CS antibody geometric mean titres (GMT) for the 3 commercial scale lots were 319.6 EU/ml (95% confidence interval (CI): 268.9-379.8), 241.4 EU/ml (207.6-280.7), and 302.3 EU/ml (259.4-352.3). Consistency for the RTS,S/AS01 commercial-scale lots was demonstrated as the two-sided 95% CI of the anti-CS antibody GMT ratio between each pair of lots was within the range of 0.5-2.0. GMT of the pooled commercial-scale lots (285.8 EU/ml (260.7-313.3)) was non-inferior to the pilot-scale lot (271.7 EU/ml (228.5-323.1)). Each RTS,S/AS01 lot had an acceptable tolerability profile, with infrequent reports of grade 3 solicited symptoms. No safety signals were identified and no serious adverse events were considered related to vaccination. RTS,S/AS01 lots formulated from commercial-scale purified antigen bulk batches induced a consistent anti-CS antibody response, and the anti-CS GMT of pooled commercial-scale lots was non-inferior to that of a lot formulated from a pilot-scale antigen bulk batch.
Output: RTS S AS01 vaccine was developed to prevent which disease?
Eugene Boban or Boban-Duverge (1834--1908) was a French antiquarian.
Output: What is the nationality of birth of Eugène Boban?
Thomas Magnay (14 September 1876 -- 3 November 1949) was a Liberal Party politician in the United Kingdom, who joined the breakaway Liberal National faction and served as a Member of Parliament (MP) from 1931 to 1945.
Output: Which country's citizen was Thomas Magnay?
In October, Ubayd Steed, a sixth grader in Philadelphia, Pennsylvania, was taking a math test when he noticed a classmate looking at his paper. " I quickly turned my paper over," he said. Later that day, Ubayd met the cheater and told him not to do it again. Unfortunately, Ubayd' s experience is not unusual. Whether it's kids copying class -mates' answers during tests or friends sharing homework, cheating happens in schools every day. Experts say the behavior starts in the lower grades. Surveys show that one in three elementary students admits to cheating. Jacob Harder, a fourth grader in Ware, Massachusetts, has had classmates ask to copy his homework. "I wouldn't want to just tell them the answers," he says. So instead, he explains the task and encourages his classmates to do it themselves. But many kids find it hard to say no. "l hear from kids all the time, ' I can' t say no to a friend,'" says Eric Anderman, a professor at The Ohio State University who studies cheating in school. He says it' s important to say no from the start. "Then you _ , and the other kid gets the message," he says. Plus, he points out, "a real friend is not going to disown you because he or she couldn't copy your math homework." The kids doing the copying may feel they need to cheat to be accepted by other kids. And some students may cheat simply because others do. "If you' re in an atmosphere where cheating is common, you may think that if you don' t cheat, you' re at a disadvantage," says Michael Josephson, founder of the Josephson Institute of Ethics. But Josephson says students shouldn't think that way. "There are a lot of things kids do," he says. "You have to decide what kind of person you' re going to be." When school becomes too challenging, Anderman suggests going to the teacher rather than relying on the work of others. "It' s good to ask for help," he says.
Output: Who advises kids to turn to teachers for help when they fall behind in studies'?
Flor Melendez Montanez (born January 12, 1947), better known plainly as Flor Melendez, is a well known former basketball player and an international coach from Puerto Rico.
Output: What sport did Flor Meléndez play?
FC Ekibastuzets are a Kazakhstani football club based at the Shakhtyor Stadium in Ekibastuz.
Output: What location hosts FC Ekibastuzets's home games?
Did you ever notice when you get into a bathtub of water that the level of the water rises? More than 2000 years ago, a Greek mathematician named Archimedes noticed the same thing. He observed that both a body and the water in a tub cant occupy the same space at the same time. As a result, some of the water is displaced, or moved out of the way. How much water is displaced? Archimedes determined that the volume of displaced water equals the volume of the submerged object. So more water is displaced by a bigger body than a smaller one. Q: If you jump into swimming pool, how much water does your body displace? A: The water displaced by your body is equal to your bodys volume. Depending on your size, this volume might be about 0.07 m3 . Objects such as ships may float in a fluid like water because of buoyant force. This is an upward force that a fluid exerts on any object that is placed in it. Archimedes discovered that the buoyant force acting on an object equals the weight of the fluid displaced by the object. This is known as Archimedes law (or Archimedes principle). Archimedes law explains why some objects float in fluids even though they are very heavy. It all depends on how much fluid they displace. The cruise ship pictured in the opening image is extremely heavy, yet it stays afloat. If a steel ball with the same weight as the ship were placed in water, it would sink to the bottom. This is modeled in the Figure 1.1. The reason the ball sinks is that its shape is very compact, so it displaces relatively little water. The volume of water displaced by the steel ball weighs less than the ball itself, so the buoyant force is not as great as the force of gravity pulling down on the ball. Thus, the ball sinks. Now look at the ships hull in the Figure 1.1. Its shape causes the ship to displace much more water than the ball. In fact, the weight of the displaced water is greater than the weight of the ship. As a result, the buoyant force is greater than the force of gravity acting on the ship, so the ship floats. Q: Why might you be more likely to float in water if you stretch out your body rather than curl up into a ball? A: You would displace more water by stretching out your body, so there would be more buoyant force acting on it. Therefore, you would be more likely to float in this position.
Output: archimedes determined that the volume of water displaced by an object placed in the water is equal to the objects
1225 Ariane, provisional designation 1930 HK, is a main-belt asteroid discovered on April 23, 1930, by Hendrik van Gent at the Leiden Southern Station, annex to the Johannesburg Observatory in South Africa.
Output: What is the name of the person who discovered 1225 Ariane?
The rash in infectious mononucleosis is usually diffusely macular. A 15-year-old boy presented to us with high grade fever, sore throat, malaise, body aches, and polyarthralgia. He developed annular, erythematous, and non-scaly eruptions on chest and right arm. Blanching erythema was noted on his trunk. He had bilateral tender cervical lymph nodes, severe pharyngeal congestion, petechiae on soft palate, uvular edema, infraorbital edema, and marginal tender hepatomegaly. Investigations revealed lymphocytosis and activated atypical lymphocytes in the peripheral smear, and positive monospot test. The boy subsequently recovered in one week with total disappearance of his rash. Epstein-Barr virus-related infectious mononucleosis was considered the most likely diagnosis for our patient. To our knowledge, this atypical case is the third reported case of annular lesions in infectious mononucleosis. Dermatologists and other clinicians should be alerted to this special presentation of primary EBV infection.
Output: Which virus can be diagnosed with the monospot test?
In 1876, William C. Bryant presented a plan to the Council of the Seneca Nation to rebury Red Jacket's remains in Forest Lawn Cemetery, Buffalo.
Output: What cemetery was Red Jacket buried ar?
Dr. Adder is an artist-surgeon, who modifies sexual organs of his patients to satisfy the weirdest of perversion; he is clearly depicted as a partly criminal, partly counter-cultural figure in a future Los Angeles which anticipates the cyberpunk idea of the Sprawl.
Output: Which place does Dr. Adder exist in?
The advent of antibiotics for the treatment of tuberculosis (TB) represented a major breakthrough in the fight against the disease. However, since its first use, antibiotic therapy has been associated with the emergence of resistance to drugs. The incorrect use of anti-TB drugs, either due to prescription errors, low patient compliance, or poor quality of drugs, led to the widespread emergence of Mycobacterium tuberculosis strains with an expanding spectrum of resistance. The spread of multidrug-resistant (MDR) strains (ie, strains resistant to both isoniazid and rifampicin) has represented a major threat to TB control since the 1990s. In 2006, the first cases of MDR strains with further resistance to fluoroquinolone and injectable drugs were described and named extensively drug-resistant TB (XDR-TB). The emergence of XDR-TB strains is a result of mismanagement of MDR cases, and treatment relies on drugs that are less potent and more toxic than those used to treat drug-susceptible or MDR strains. Furthermore, treatment success is lower and mortality higher than achieved in MDR-TB cases, and the number of drugs necessary in the intensive phase of treatment may be higher than the four drugs recommended for MDR-TB. Linezolid may represent a valuable drug to treat cases of XDR-TB. Delamanid, bedaquiline, and PA-824 are new anti-TB agents in the development pipeline that have the potential to enhance the cure rate of XDR-TB. The best measures to prevent new cases of XDR-TB are the correct management of MDR-TB patients, early detection, and proper treatment of existing patients with XDR-TB.
Output: Which disease can be treated with Delamanid?
Alexis Tomassian (sometimes credited as Alexis Thomassian) is a French dubbing actor born on July 13, 1979.
Output: What is the national identity of Alexis Tomassian?
The Olympic Marathon took place on 10 April (O.S. 29 March) 1896, and another female runner, Stamata Revithi, took 5 hours to run the course on 11 April (O.S. 30 March) 1896.
Output: What was Stamata Revithi's gender?
Atg8-family proteins are the best-studied proteins of the core autophagic machinery. They are essential for the elongation and closure of the phagophore into a proper autophagosome. Moreover, Atg8-family proteins are associated with the phagophore from the initiation of the autophagic process to, or just prior to, the fusion between autophagosomes with lysosomes. In addition to their implication in autophagosome biogenesis, they are crucial for selective autophagy through their ability to interact with selective autophagy receptor proteins necessary for the specific targeting of substrates for autophagic degradation. In the past few years it has been revealed that Atg8-interacting proteins include not only receptors but also components of the core autophagic machinery, proteins associated with vesicles and their transport, and specific proteins that are selectively degraded by autophagy. Atg8-interacting proteins contain a short linear LC3-interacting region/LC3 recognition sequence/Atg8-interacting motif (LIR/LRS/AIM) motif which is responsible for their interaction with Atg8-family proteins. These proteins are referred to as LIR-containing proteins (LIRCPs). So far, many experimental efforts have been carried out to identify new LIRCPs, leading to the characterization of some of them in the past 10years. Given the need for the identification of LIRCPs in various organisms, we developed the iLIR database ( [Link] ) as a freely available web resource, listing all the putative canonical LIRCPs identified in silico in the proteomes of 8 model organisms using the iLIR server, combined with a Gene Ontology (GO) term analysis. Additionally, a curated text-mining analysis of the literature permitted us to identify novel putative LICRPs in mammals that have not previously been associated with autophagy.
Output: Which web resource for LIR motif-containing proteins in eukaryotes has been developed?
Totalschaden (Total Damage) is the debut album of the German hip hop artist Tony D. It was released on 14 September 2007 by the label Aggro Berlin.
Output: What is the name of Totalschaden's record label?
A Vampyre Story is a 2008 point-and-click adventure game developed by Autumn Moon Entertainment for Windows, published by Crimson Cow.
Output: Which company developed the videogame A Vampyre Story?
The playwright George Bernard Shaw once said humorously, "England and America are two nations divided by a common language. If he were writing today, he might add 'divided by a common technology--- e-mail'". Two completely different styles of e-mail have formed on either side of the Atlantic-Euromail and Amerimail. Americail is informal and chatty. It's likely to begin with a "Hi" and end with a "Bye". The chances of Amerimail containing a smiley face or an "xoxo" are disturbingly high. We Americans are unwilling to dive into the meat of an e-mail. We feel we have to first inform recipients about our vacation on the island which was really excellent except the jellyfish were biting and the kids caught a cold, so we had to skip the whale watching trip, then about that investors ' meeting in New York. Amerimail is a bundle of contradictions, casual and yet direct, respectful yet over proud. In other words, Amerimail is America. Euromail is stiff and cold often beginning with a formal "Dear Mr. X" and ending with a simple "Sincerely". You won't find any mention of kids or the weather or jellyfish in Euromail. It's all business. It's also slow. Your correspondent might take days even weeks to answer a message. Euromail is exactly like the Europeans themselves. Recently about 100 managers were asked on both sides of the Atlantic whether they noticed differences in e-mail styles. Most said yes. Here are a few of their observations: "Americans tend to write (e-mail) exactly as they speak." "Why don't you just call me instead of writing five e-mails back and forth?" "Europeans are less interested in checking e-mail". "In general, Americans are much more responsive to e-mail--they respond faster and provide more information." So which is better, Euromail or Amerimail? I realized it's not popular these days to suggest we have anything to learn from Europeans, but I'm fed up with an inbox filled with casual, barely meaningful e-mails from friends and colleagues. If the alternative is a few earnestly written, carefully worded bits of Euromail, then I say, "Bring it on."
Output: What are characteristics of Amerimail?
Copper of Kargaly origin was distributed during Bronze Age over a vast territory within the steppe and forest-steppe of Eastern Europe.
Output: What is the product of Kargaly?
Paramount Pictures CEO at the time Barry Diller wanted Schneider to produce films for him and agreed to finance Days of Heaven.
Output: What company was Days of Heaven released by?
Polycystic kidney disease (PKD) includes a group of disorders that are characterized by the presence of cysts in the kidney and other organs, including the pancreas. Here we show that in orpk mice, a model system for PKD that harbors a mutation in the gene that encodes the polaris protein, pancreatic defects start to occur at the end of gestation, with an initial expansion of the developing pancreatic ducts. Ductal dilation continues rapidly after birth and results in the formation of large, interconnected cysts. Expansion of pancreatic ducts is accompanied by apoptosis of neighboring acinar cells, whereas endocrine cell differentiation and islet formation appears to be unaffected. Polaris has been shown to co-localize with primary cilia, and these structures have been implicated in the formation of renal cysts. In the orpk pancreas, cilia numbers are reduced and cilia length is decreased. Expression of polycystin-2, a protein involved in PKD, is mislocalized in orpk mice. Furthermore, the cellular localization of beta-catenin, a protein involved in cell adhesion and Wnt signaling, is altered. Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas.
Output: Which is the most common disease attributed to malfunction or absence of primary cilia?
Milan Sablik (Czech pronunciation: (mlan sablik); Zdar nad Sazavou, 14 March 1991) is a Czech speedskater and the younger brother of Martina Sablikova, the 2007 European Champion and double World Single Distances Champion.
Output: Which woman was the sister of Milan Sáblík?
The transcriptional networks that regulate embryonic stem (ES) cell pluripotency and lineage specification are the subject of considerable attention. To date such studies have focused almost exclusively on protein-coding transcripts. However, recent transcriptome analyses show that the mammalian genome contains thousands of long noncoding RNAs (ncRNAs), many of which appear to be expressed in a developmentally regulated manner. The functions of these remain untested. To identify ncRNAs involved in ES cell biology, we used a custom-designed microarray to examine the expression profiles of mouse ES cells differentiating as embryoid bodies (EBs) over a 16-d time course. We identified 945 ncRNAs expressed during EB differentiation, of which 174 were differentially expressed, many correlating with pluripotency or specific differentiation events. Candidate ncRNAs were identified for further characterization by an integrated examination of expression profiles, genomic context, chromatin state, and promoter analysis. Many ncRNAs showed coordinated expression with genomically associated developmental genes, such as Dlx1, Dlx4, Gata6, and Ecsit. We examined two novel developmentally regulated ncRNAs, Evx1as and Hoxb5/6as, which are derived from homeotic loci and share similar expression patterns and localization in mouse embryos with their associated protein-coding genes. Using chromatin immunoprecipitation, we provide evidence that both ncRNAs are associated with trimethylated H3K4 histones and histone methyltransferase MLL1, suggesting a role in epigenetic regulation of homeotic loci during ES cell differentiation. Taken together, our data indicate that long ncRNAs are likely to be important in processes directing pluripotency and alternative differentiation programs, in some cases through engagement of the epigenetic machinery.
Output: Which is the histone residue methylated by MLL1?
Acceleration is a measure of the change in velocity of a moving object. It measures the rate at which velocity changes. Velocity, in turn, is a measure of the speed and direction of motion, so a change in velocity may reflect a change in speed, a change in direction, or both. Both velocity and acceleration are vectors. A vector is any measurement that has both size and direction. People commonly think of acceleration as in increase in speed, but a decrease in speed is also acceleration. In this case, acceleration is negative and called deceleration. A change in direction without a change in speed is acceleration as well. Q: Can you think of an example of acceleration that doesnt involve a change in speed? A: Driving at a constant speed around a bend in a road is one example. Use your imagination to think of others. You can see several examples of acceleration in the pictures from the Figure 1.1. In each example, velocity is changing but in different ways. For example, direction may be changing but not speed, or vice versa. Figure out what is moving and how its moving in each of the photos. Q: Describe how velocity is changing in each of the motions you identified from the Figure 1.1. A: You should describe how both direction and speed are changing. For example, the boy on the carousel is moving up and down and around in a circle, so his direction is constantly changing, but his speed changes only at the beginning and end of the ride. The skydiver is falling straight down toward the ground so her direction isnt changing, but her speed keeps increasing as she falls until she opens her parachute. If you are accelerating, you may be able to feel the change in velocity. This is true whether the change is in speed, direction, or both. You often feel acceleration when you ride in a car. As the car speeds up, you feel as though you are being pressed against the seat. When the car slows down, you feel like you are being pushed forward, especially if the change in speed is sudden. If the car changes direction and turns right, you feel as though you are being pushed to the left. With a left turn, you feel a push to the right. The next time you ride in a car, notice how it feels as the car accelerates in each of these ways.
Output: acceleration always refers to a(n)
A diverse collection of 261 Staphylococcus aureus strains from human, animal, food, and environmental sources were tested for the presence and type of SCCmec elements, antibiotic susceptibility to various antibiotics, and non--lactam antibiotic resistance genes. About 18.39% (48/261) of strains were methicillin-resistant S. aureus (MRSA) including 29.75% (36/121) human strains of which 29 strains were hospital-acquired MRSA (HA-MRSA) and 7 strains were community-associated MRSA (CA-MRSA) and 19.67% (12/61) animal strains that all were CA-MRSA strains. The percentage of CA-MRSA strains from animals was significantly higher than that from human (p<0.01). Most of MRSA strains and a part of methicillin-susceptible S. aureus (MSSA) strains harbored unique combinations of non--lactamase genes aac(6')/aph(2), aph(3')-III, ant (4',4), ermA, ermC, mrsA, tetM, and tetK. Antibiotic resistance genes were detected more frequently in HA-MRSA strains than in CA-MRSA strains (p<0.01). MRSA strains and MSSA strains had 22 and 39 antibiotic profiles to 15 tested antibiotics, respectively. The resistant proportion was higher in HA-MRSA strains than in CA-MSSA strains for various antibiotics, as well as higher in MRSA strains than in MSSA strains. Animal MRSA reservoirs (particularly pigs and cows) might represent an important source of human CA-MRSA. CA-MRSA strains might acquire more different resistance genes gradually, depending on the selective pressure of antibiotics in different regions or environments. CA-MRSA is not yet endemic in China, but could be prevalent in future, contributing to its acquiring more resistance genes and huge animal sources. Infection with multidrug-resistant MSSA strains acquired from food, animal, and human sources might also become a significant problem for human medicine, which warrants further study.
Output: What is MRSA?
Yakup Ramazan Zorlu (born 26 March 1991) is a Turkish professional footballer who plays for Kayseri Erciyesspor.
Output: What team does Yakup Ramazan Zorlu play for?
The People's Unity Assembly (Catalan: Assemblea d'Unitat Popular, AUP) was an independentist organization and movement active between 1993 and 1996.
Output: What year was People's Unity Assembly formed in?
Elizabeth Blackwell was born in England in 1821, and moved to New York City when she was ten years old. One day she decided that she wanted to become a doctor. That was nearly impossible for a woman in the middle of the nineteenth century. After writing many letters asking for admission to medical schools, she was finally accepted by a doctor in Philadelphia. She was so determined that she taught school and gave music lessons to get money for the cost of schooling. In 1849, after graduation from medical school, she decided to further her education in Paris. She wanted to be a surgeon , but a serious eye problem forced her to give up the idea. Upon returning to the United States, she found it difficult to start her own practice because she was a woman. By 1857 Elizabeth and her sister, also a doctor, along with another woman doctor, managed to open a new hospital, the first for women and children. Besides being the first woman physician and founding her own hospital , she also set up the first medical school for women.
Output: What main obstacle  almost destroyed Elizabeth's chances for becoming a doctor?
''Sworn to the Sword'' is the sixth episode of the second season of American animated television series Steven Universe, which premiered on June 15, 2015 on Cartoon Network.
Output: What series is Sworn to the Sword from?
HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors.
Output: Which species has the HLA-C gene?
To compare the sensitivity and specificity of bedside diagnostic stroke scales in patients with suspected stroke. A cross-sectional observational study of patients with suspected acute stroke in an emergency department in a UK hospital. DIAGNOSTIC SCALES: The results of an assessment with the Recognition of Stroke in the Emergency Room (ROSIER) scale, the Face Arm Speech Test (FAST) scale and the diagnosis of definite or probable stroke by an emergency department. Reference standard A consensus diagnosis of stroke or transient ischaemic attack (TIA) made after discussion by an expert panel (members included stroke physicians, neurologists and neuroradiologists), who had access to the clinical findings, imaging and subsequent clinical course, but were blinded to the results of the assessments by emergency-department staff. In 356 patients with complete data, the expert panel assigned a diagnosis of acute stroke or TIA in 246 and a diagnosis of mimic in 110. The ROSIER had a sensitivity of 83% (95% CI 78 to 87) and specificity of 44% (95% CI 34 to 53), and the FAST had a sensitivity of 81% (95% CI 76 to 86) and a specificity of 39% (95% CI 30 to 48). There was no detectable difference between the scales in sensitivity (p = 0.39) or specificity (p = 0.30). The simpler FAST scale could replace the more complex ROSIER for the initial assessment of patients with suspected acute stroke in the emergency department.
Output: ROSIER scale is used for which disorder?
The Christmas Creek, a perennial stream that is part of the Macleay River catchment, is located in the Mid North Coast region of New South Wales, Australia.
Output: What body of water does Christmas Creek join?
A 60-year-old man diagnosed clinically with Becker's muscular dystrophy 20 years ago by another physician presented with gradually progressive proximal muscle weakness since teenage years. Family history revealed a strong paternal familial inheritance pattern of similar distribution of weakness-face, forearm flexion, knee extension and foot dorsiflexion. Work-ups revealed B12 deficiency and allele 1 deletion in fascioscapulohumeral muscular dystrophy (FSHD) DNA testing. FSHD is the third most common muscular dystrophy. Clinical diagnosis is made from the distinctive pattern of weakness, autosomal-dominant inheritance, and confirmed by genetic testing. This case strongly demonstrates the importance of a thorough and careful clinical evaluation even in a case with a long standing diagnosis.
Output: What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?
Peter Miller Cunningham was the fifth son of John Cunningham, land steward and farmer (1743--1800), and brother of Thomas Mounsey Cunningham (1776--1834) and of Allan Cunningham (1784--1842).
Output: Who was the brother of Peter Miller Cunningham?
"Just ate chicken feet for lunch. " These were the words I wrote on my blog yesterday. By the next day there were hundreds of comments from my friends. They ranged from "OH MY GOD! That is so disgusting! " to "What were they like?" to "Why can't you eat sandwiches like everyone else?" To Chinese people, chicken feet are a normal snack. To my friends in Britain, the thought of eating a chicken's foot is----well, weird . As weird, in fact, as eating a bullfrog, scorpion , snake, or turtle. But if there are two things I love more than anything else in life, they are: trying new things and food. I arrived in Beijing five months ago. Since then, I've searched for the "weirdest" foods so I can try them, then treat my friends to some "virtual eating" on my blog. One weekend, I went to Wangfujing, Beijing's "snack street". The trip gave me tons of blog material. "I chose a stick with three live, wriggling scorpions on it," I wrote. "And it was pretty good. The scorpion was warm and crispy. The legs did have a tendency to get stuck between one's teeth, however. What's more, I am sure scorpion number two stung me with its tail in revenge ." Next came snake: "A bit like a cross between fish and chicken, with a slightly rubbery texture and meaty taste." Some people were actually angry when I ate turtle soup----especially when I posted pictures showing the poor little guy's head staring sadly up at us from the bowl. "I am never speaking to you again," wrote one (former) friend. Still, I will continue my culinary quest. Next on my list is starfish, though I feel I should have some vegetables too----algae, maybe. So what am I eating, tonight, you may ask. Pizza. Well, a girl's gotta have a break sometimes.
Output: What does the writer like most in life?
The multidrug resistance 1 gene (MDR1) encodes P-glycoprotein (Pgp), a member of the ATP-binding cassette (ABC) transporter family that confers tumor drug resistance by actively effluxing a number of antitumor agents. We had previously shown that MDR1 transcription is regulated by epigenetic events such as histone acetylation, and had identified the histone acetylase P/CAF and the transcription factor NF-Y as the factors mediating the enzymatic and DNA-anchoring functions, respectively, at the MDR1 promoter. It has also been shown that MDR1 activation is accompanied by increased methylation on lysine 4 of histone H3 (H3K4). In this study, we further investigated histone methylation in MDR1 regulation and function. We show that the mixed lineage leukemia 1 (MLL1) protein, a histone methyltransferase specific for H3K4, is required for MDR1 promoter methylation, as knockdown of MLL1 resulted in a decrease in MDR1 expression. The regulation of MDR1 by MLL1 has functional consequences in that downregulation of MLL1 led to increased retention of the Pgp-specific substrate DIOC(2)(3), as well as increased cellular sensitivity to several Pgp substrates. Regulation of MDR1 by MLL1 was dependent on the CCAAT box within the proximal MDR1 promoter, similar to what we had shown for MDR1 promoter acetylation, and also requires NF-Y. Finally, overexpression of the most prevalent MLL fusion protein, MLL-AF4, led to increased MDR1 expression. This is the first identification of a histone methyltransferase and its leukemogenic rearrangement that regulates expression of an ABC drug transporter, suggesting a new target for circumvention of tumor multidrug resistance.
Output: Which is the histone residue methylated by MLL1?
Anderson-Fabry disease (referred to as Fabry disease) is an X-linked disorder characterized by a deficiency of the lysosomal enzyme alpha-galactosidase A and the subsequent accumulation in various tissues of globotriaosylceramide (Gb(3)), the main substrate of the defective enzyme. Enzyme replacement therapy (ERT) offers a specific treatment for patients with Fabry disease, though monitoring of treatment is hampered by a lack of surrogate markers of response. In this study, the efficacy of long-term ERT in six Fabry hemizygotes and two symptomatic heterozygotes has been evaluated. Patients were administered recombinant alpha-galactosidase A every 2 weeks for up to a year. The efficacy of ERT was assessed by monitoring symptomatology and renal function. Urinary glycolipid concentration was estimated by a novel tandem mass spectrometric method. Urine glycolipid (Gb(3)) was elevated at baseline and fell impressively on ERT where patients were hemizygotes and in the absence of renal transplantation. In heterozygotes and in a recipient of a renal allograft, elevations and changes in urine glycolipids were less pronounced. In one patient, after several months of ERT, there was a transient increase in Gb(3) concentrations to baseline (pre-ERT) levels, associated with the presence of antibodies to the recombinant alpha-galactosidase A. The marked decline in urine Gb(3) on ERT, and its subsequent increase in association with an inhibitory antibody response, suggest that this analyte deserves further investigation as a potential marker of disease severity and response to treatment.
Output: Which is the defective protein causing the lysosomal storage disease Fabry?
Ptolemy III Euergetes (Greek: , Ptolemaios Euergetes, reigned 246--222 BC) was the third king of the Ptolemaic dynasty in Egypt.
Output: What family lineage was Ptolemy III Euergetes part of?
Peter van Straaten (born 25 March 1935 in Arnhem) is a Dutch cartoonist and comics artist.
Output: What was the nationality of Peter van Straaten?
The Many Faces of Oliver Hart is a studio album by Eyedea, released under the pseudonym Oliver Hart.
Output: Whose performance is The Many Faces of Oliver Hart?
Clustrix, Inc. is a San Francisco-based company that develops a NewSQL Database.
Output: What city is Clustrix located in?
The Geysers were first seen by Euro/Americans and named in 1847 during John Fremont's survey of the Sierra Mountains and the Great Basin by William Bell Elliot who called the area ''The Geysers,'' although the geothermal features he discovered were not technically geysers, but fumaroles.
Output: When was the The Geysers discovered?