niryuu/sni-each-converted huggingface dataset:
The army defending Constantinople was relatively small, totaling about 7,000 men, 2,000 of whom were foreigners. At the onset of the siege, probably fewer than 50,000 people were living within the walls, including the refugees from the surrounding area.:32 Turkish commander Dorgano, who was in Constantinople in the pay of the Emperor, was also guarding one of the quarters of the city on the seaward side with the Turks in his pay. These Turks kept loyal to the Emperor and perished in the ensuing battle. The defending army's Genoese corps were well trained and equipped, while the rest of the army consisted of small numbers of well-trained soldiers, armed civilians, sailors and volunteer forces from foreign communities, and finally monks. The garrison used a few small-calibre artillery pieces, which nonetheless proved ineffective. The rest of the city repaired walls, stood guard on observation posts, collected and distributed food provisions, and collected gold and silver objects from churches to melt down into coins to pay the foreign soldiers. The Ottomans had a much larger force. Recent studies and Ottoman archival data state that there were about 50,000-80,000 Ottoman soldiers including between 5,000 and 10,000 Janissaries, *70 cannons:139-140 an elite infantry corps, and thousands of Christian troops, notably 1,500 Serbian cavalry that the Serbian lord ura Brankovic was forced to supply as part of his obligation to the Ottoman sultanjust a few months before, he had supplied the money for the reconstruction of the walls of Constantinople. Contemporaneous Western witnesses of the siege, who tend to exaggerate the military power of the Sultan, provide disparate and higher numbers ranging from 160,000 to 200,000 and to 300,000.
Output: Which force was smaller, the Turkish or the Ottomans?
Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein translocation, and signal transduction. Lysine methylation is best known to regulate histone function and is involved in epigenetic regulation of gene transcription. To better study protein methylation, we have developed highly specific antibodies against monomethyl arginine; asymmetric dimethyl arginine; and monomethyl, dimethyl, and trimethyl lysine motifs. These antibodies were used to perform immunoaffinity purification of methyl peptides followed by LC-MS/MS analysis to identify and quantify arginine and lysine methylation sites in several model studies. Overall, we identified over 1000 arginine methylation sites in human cell line and mouse tissues, and 160 lysine methylation sites in human cell line HCT116. The number of methylation sites identified in this study exceeds those found in the literature to date. Detailed analysis of arginine-methylated proteins observed in mouse brain compared with those found in mouse embryo shows a tissue-specific distribution of arginine methylation, and extends the types of proteins that are known to be arginine methylated to include many new protein types. Many arginine-methylated proteins that we identified from the brain, including receptors, ion channels, transporters, and vesicle proteins, are involved in synaptic transmission, whereas the most abundant methylated proteins identified from mouse embryo are transcriptional regulators and RNA processing proteins.
Output: Name a method for enrichment of arginine-methylated peptides.
Warsaw produces 12% of Polands national income, which in 2008 was 305.1% of the Polish average per capita (or 160% of the European Union average). The Nominal GDP per capita in Warsaw amounted to PLN 134,000 in 2015 (c. 31,200 or $74,400 in Purchasing Power Parity). Total nominal GDP of the city in 2010 amounted to 191.766 billion PLN, 111,696 PLN per capita, which was 301.1% of the Polish average. Warsaw leads East-Central Europe in foreign investment and in 2006, GDP growth met expectations with a level of 6.1%. It also has one of the fastest growing economies, with GDP growth at 6.5 percent in 2007 and 6.1 percent in the first quarter of 2008.
Output: Which GDP growth was higher, 2007 or first quarter of 2008?
Neurofibromatosis type 1 (NF1) is a common disorder of dysregulated tissue growth secondary to mutations in the tumor suppressor gene NF1. Pulmonary arterial hypertension (PAH) in patients with NF1 is hypothesized to be secondary to an underlying vasculopathy. We describe the entity we term NF1-associated PAH (NF1-PAH) in four new patients and update the data on four previously published reports of patients with PAH and NF1. We performed genetic testing of the bone morphogenic protein receptor 2 (BMPR2) gene, which mutated in 70% of patients with familial PAH and approximately 25% of patients with idiopathic PAH. We report, for the first time, pathologic findings in the autopsy-obtained lung of one patient with NF1-PAH. Patients with NF1-PAH have a generally poor long-term prognosis. In four patients, we observed the mosaic pattern of lung attenuation on a CT scan of the chest, a radiographic finding that can be consistent with an underlying vasculopathy. No mutations or rearrangements in the BMPR2 gene were found. We observed complex plexiform lesions in the one available autopsy specimen. Similar lesions are a hallmark of plexogenic pulmonary arteriopathy and are associated with several severe types of PAH. (Plexiform lesions should not be confused with plexiform neurofibromas, which are distinctive tumors seen in NF1.) Our findings suggest that NF1 should be considered as being "associated with PAH as outlined in the Revised Clinical Classification of Pulmonary Hypertension. Understanding the mechanism of PAH in NF1 may inform the pathogenesis of PAH, NF1-PAH itself, and other NF1-associated vasculopathies. The pulmonary vasculature should now be included among the arterial beds affected by NF1 vasculopathy.
Output: Which is the gene mutated in type 1 neurofibromatosis?
In August 2009, Ocwen completed the distribution of its Ocwen Solutions (OS) line of business via the spin-off of a separate publicly traded company, Altisource (NASDAQ: ASPS).
Output: Which exchange is Ocwen listed with?
It is well known that autonomic failure is severer in patients with dementia with Lewy bodies (DLB) compared with patients with Parkinson's disease (PD). According to the Braak's hypothesis, Lewy bodies first appear in the olfactory bulb or peripheral autonomic nervous system. Lewy bodies in the peripheral autonomic nervous system ascend to dorsal motor nuclei of vagus nerve, while those in the olfactory bulb expand to the limbic system. Lewy bodies later attain the substantia nigra. However, it seems that Braak staging can not explain difference in severity of autonomic failure between DLB and PD. As a possibility, in DLB patients with significant autonomic failure, Lewy bodies may have been localized to the peripheral autonomic nervous system in a long time before onset of dementia or parkinsonism, and propagation of Lewy bodies into the central nervous system may be initiated by apparition of certain promotion factor, such as ageing and amyloid-.
Output: Which disease of the central nervous system is characterized by the presence of Lewy bodies?
Thompson sampling was originally described in an article by Thompson from 1933 but has been largely ignored by the artificial intelligence community.
Output: At which time was Thompson sampling discovered?
''The Biggest Douche in the Universe'' is the 15th episode of the sixth season and the 94th overall episode of the Comedy Central animated series South Park.
Output: What is the series called that The Biggest Douche in the Universe belongs to?
McLeod syndrome is an X-linked multisystem disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. We have assembled a cosmid contig of 360 kb that encompasses the McLeod gene locus. A 50 kb deletion was detected by screening DNA from patients with radiolabeled whole cosmids, and two transcription units were identified within this deletion. The mRNA expression pattern of one of them, designated as XK, correlates closely to the McLeod phenotype. XK encodes a novel protein with structural characteristics of prokaryotic and eukaryotic membrane transport proteins. Nucleotide sequence analysis of XK from two unrelated McLeod patients has identified point mutations at conserved splice donor and acceptor sites. These findings provide direct evidence that XK is responsible for McLeod syndrome.
Output: Mutation of which gene is associated with McLeod syndrome?
They Met in Argentina is a 1941 American film, directed by Leslie Goodwins and Jack Hively for RKO Pictures, Hively had to come in and finish the picture after Goodwins was hospitalized for pneumonia.
Output: What was the name of the director for They Met in Argentina?
To evaluate the long-term impact of successive interventions on rates of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection and MRSA bacteremia in an endemic hospital-wide situation. Quasi-experimental, interrupted time-series analysis. The impact of the interventions was analyzed by use of segmented regression. Representative MRSA isolates were typed by use of pulsed-field gel electrophoresis. A 950-bed teaching hospital in Seville, Spain. All patients admitted to the hospital during the period from 1995 through 2008. Three successive interventions were studied: (1) contact precautions, with no active surveillance for MRSA; (2) targeted active surveillance for MRSA in patients and healthcare workers in specific wards, prioritized according to clinical epidemiology data; and (3) targeted active surveillance for MRSA in patients admitted from other medical centers. Neither the preintervention rate of MRSA colonization or infection (0.56 cases per 1,000 patient-days [95% confidence interval {CI}, 0.49-0.62 cases per 1,000 patient-days]) nor the slope for the rate of MRSA colonization or infection changed significantly after the first intervention. The rate decreased significantly to 0.28 cases per 1,000 patient-days (95% CI, 0.17-0.40 cases per 1,000 patient-days) after the second intervention and to 0.07 cases per 1,000 patient-days (95% CI, 0.06-0.08 cases per 1,000 patient-days) after the third intervention, and the rate remained at a similar level for 8 years. The MRSA bacteremia rate decreased by 80%, whereas the rate of bacteremia due to methicillin-susceptible S. aureus did not change. Eighty-three percent of the MRSA isolates identified were clonally related. All MRSA isolates obtained from healthcare workers were clonally related to those recovered from patients who were in their care. Our data indicate that long-term control of endemic MRSA is feasible in tertiary care centers. The use of targeted active surveillance for MRSA in patients and healthcare workers in specific wards (identified by means of analysis of clinical epidemiology data) and the use of decolonization were key to the success of the program.
Output: What is MRSA?
We investigated the requirements for selenocysteine insertion at single or multiple UGA codons in eukaryotic selenoproteins. Two functional SECIS elements were identified in the 3' untranslated region of the rat selenoprotein P mRNA, with predicted stem-loops and critical nucleotides similar to those in the SECIS elements in the type I iodothyronine 5' deiodinase (5'DI) and glutathione peroxidase selenoprotein mRNAs. Site-directed mutational analyses of three SECIS elements confirmed that conserved nucleotides in the loop and in unpaired regions of the stem are critical for activity. This indicates that multiple contact sites are required for SECIS function. Stop codon function at any of five out-of-context UGA codons in the 5'DI mRNA was suppressed by SECIS elements from the 5'DI or selenoprotein P genes linked downstream. Thus, the presence of SECIS elements in eukaryotic selenoprotein mRNAs permits complete flexibility in UGA codon position.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Ravenea rivularis is an endangered species of flowering plant in the Arecaceae family.
Output: What is the iucn conservation status of Ravenea rivularis?
Oedipus and the Sphinx is an 1864 oil on canvas painting by Gustave Moreau that was first exhibited at the French Salon of 1864 where it was an immediate success.
Output: What is the surface of Oedipus and the Sphinx made of?
Precursor cells have been shown to be affected by oxidative stress, in vivo and vitro, but little is known about the expression of antioxidant mechanisms in neuronal/glial differentiation. We have characterized the expression of Cu/Zn superoxide dismutase (Cu/Zn SOD), one of the main antioxidant proteins involved in the breakdown of superoxide, in the immature rat dorsolateral subventricular zone (SVZ), rostral migratory stream (RMS) and hippocampal subgranular zone (SGZ). Progenitor cells were identified immunohistochemically on cryostat sections by 5'Bromodeoxyuridine (BrdU) incorporation and expressing cells were further characterized using double labeling for progenitor markers. In the SVZ, only a subpopulation of BrdU+ cells, mostly found in the medial SVZ, expressed Cu/Zn SOD. These cells were mostly nestin+ and some were also vimentin+. In contrast, in the lateral SVZ few Cu/Zn SOD+/BrdU+ cells were found. These were primarily nestin+, vimentin-, showed some PSA-NCAM expression, but only a few were NG2+. In the RMS and SGZ virtually all BrdU+ progenitors were Cu/Zn SOD+ and expressed nestin and vimentin. Some RMS cells were also PSA-NCAM+. These findings show a heterogeneous expression of Cu/Zn SOD in restricted cell types in the germinative zones and suggest a role for antioxidant Cu/Zn SOD in progenitor cells of the immature rat brain.
Output: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
The overlap between symptoms of PTSD and MDD is substantial. PTSD symptoms arise after a traumatic experience and the trauma is present in all of the diagnostic clusters. In individuals who have experienced a trauma a long time before, it is difficult to establish the exact moment of onset of their symptoms in relation to the trauma suffered. We proposed to raise awareness among operators who may encounter this problem, with the aim of providing them with valuable help in order to achieve a correct differential diagnosis. A sample of subjects suffering from PTSD without comorbidity was assessed to confirm the diagnosis and the severity of post-traumatic symptoms. The Kruskal-Wallis test was used to compare any modifications in the parameters analyzed through the Davidson Trauma Scale with the presence and severity of depressive symptoms as evaluated by the Hamilton-D scale. Half of the PSTD patients recruited showed values of HAM-D > 18, although an active Major Depressive Episode was clinically excluded. Symptom of "numbing", despite being different from the apathy experienced in depression, is identified as a depressive symptom by the HAM-D. Giving prevalence to depressive symptoms may be misleading for diagnosis and may ultimately result in inappropriate treatment.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
In anaesthesia and in the intensive care unit, benzodiazepines have proven safe and effective agents for the induction and maintenance of sedation for a variety of therapeutic goals. However, in these contexts, or in benzodiazepine overdose, it is often desirable to be able to terminate or interrupt sedation without waiting for the effect of the benzodiazepine to become dissipated by normal metabolism and excretion. Flumazenil, a 1,4-imidazobenzodiazepine, is a highly effective, specific benzodiazepine antagonist which is indicated for use when the effect of a benzodiazepine must be attenuated or terminated at short notice. It acts by displacing other benzodiazepines from the receptor site by competitive inhibition. The onset of effect after intravenous administration occurs within 1 to 3 minutes. The optimal dosage is determined for each patient by a dose titration procedure and lies in the range 0.2 to 1.0mg in anaesthesiology, and 0.1 to 2.0mg in intensive care use. Despite its short elimination half-life of around 1 hour, after general anaesthesia or conscious to moderate sedation for short procedures, a single dose of flumazenil is usually sufficient to attain and maintain the desired level of consciousness. After intoxication with high benzodiazepine doses, the duration of effect of a single dose of flumazenil is not expected to exceed 1 hour. In such cases, the period of wakefulness can be prolonged as necessary by repeated low intravenous doses of flumazenil or by infusion (0.1 mg/hour). Flumazenil is well tolerated both systemically and locally. The only adverse events seen with greater frequency after flumazenil compared with placebo were nausea and/or vomiting after general anaesthesia, although the incidence of actual vomiting was not significantly different between the 2 groups. Since these effects were virtually absent in studies of intensive care patients and after sedation for short procedures, and were not seen in tolerability studies in healthy volunteers receiving intravenous bolus doses of up to 100mg, there may be a link between these symptoms and the other agents used in general anaesthesia, some of which have well-known emetic properties. Thus, flumazenil provides a safe and effective means of attenuating or reversing the CNS-depressant effects of benzodiazepines whenever indicated, e.g. following benzodiazepine-induced general anaesthesia, conscious sedation, or after benzodiazepine overdose, either alone or in combination with other agents.(ABSTRACT TRUNCATED AT 400 WORDS)
Output: Which drug should be used as an antidote in benzodiazepine overdose?
A "secret" message, unseen for almost 150 years and making the start of the U.S. Civil War (1861-1865), has been uncovered in Abraham Lincoln's gold pocket watch, prefix = st1 /U.S.media reported on Wednesday. "Lincolnnever knew of the message he carried in his pocket," Brent D. Glass, director of the National Museum of American History said in a statement. The message, which was engraved by an Irish immigrant and watchmaker named Jonathan Dillon, is dated April 13, 1861, and reads in part: "FortSumpter[sic] was attacked by the rebels" and "thank God we have a government." "It's a personal side of history about an ordinary watchman being inspired to record something for _ ," Glass said. The museum decided to open the watch after being contacted by the watchmaker's great-great-grandson, Doug Stiles, who had received a letter from a in Ireland. It said that the family had found a letter Dillon had written about the purported message in the watch. Then Stiles, a 57 -year-old real estate lawyer in Waukegan,Illinois, searched on the Internet and found a New York Times article from 1906, where Dillon told the story at the age of 84. During the interview, Dillon said that he unscrewed the dial of the watch and wrote on the metal as soon as he heard the news about the first shot of the Civil War. "The first gun is fired. Slavery is dead. Thank God we have a President who at least will try." However, the actual message that the museum found is different from what Dillon recalled. It reads, "Jonathan Dillon, April 13-1861, Fort Sumpter [sic] was attacked by the rebels on the above date J Dillon, April 13 -1861, Washington, thank God we have a government, Jonth Dillon."
Output: Who wrote the message in Abraham Lincoln's pocket watch?
Marilyn Hotchkiss' Ballroom Dancing and Charm School is a 2005 musical romance film produced by Samuel Goldwyn Films and directed by Randall Miller.
Output: What company released Marilyn Hotchkiss' Ballroom Dancing and Charm School?
Coming off a two-game winning streak, the Broncos headed to Lucas Oil Stadium to play the undefeated Colts. In the first half, the Colts jumped out to a 21-0 lead. Denver finally scored when Kyle Orton found Brandon Marshall in the end zone going to the locker rooms trailing 21-7. For most of the second half, the Colts offense sputtered. In a long drive, Orton found Marshall for his second touchdown, however, the two-point conversion was no good, making the score 21-16. Then the Colts offense got things going late in the fourth. After a long drive, Manning found Dallas Clark in the end zone for his third touchdown of the day, putting the Colts on top 28-16 with under three minutes left in the game. On a long fourth down, Orton found Marshall who lateraled the ball to a lineman who was tackled short of the first down. With the win, the Colts broke an NFL record with 23 straight wins. Though despite the loss, Broncos WR Brandon Marshall had a record of his own with 21 catches beating Terrell Owens' record.
Output: Which team member also broke a record?
The generation of reactive oxygen species (ROS) is required for proper cell signaling, but must be tightly regulated to minimize deleterious oxidizing effects. Activation of the NADPH oxidases (Nox) triggers ROS production and, thus, regulatory mechanisms exist to properly control Nox activity. In this study, we report a novel mechanism in which Nox1 activity is regulated through the proteasomal degradation of Nox organizer 1 (NoxO1). We found that through the interaction between NoxO1 and growth receptor-bound protein 2 (Grb2), the Casitas B-lineage lymphoma (Cbl) E3 ligase was recruited, leading to decreased NoxO1 stability and a subsequent reduction in ROS generation upon epidermal growth factor (EGF) stimulation. Additionally, we show that EGF-mediated phosphorylation of NoxO1 induced its release from Grb2 and facilitated its association with Nox activator 1 (NoxA1) to stimulate ROS production. Consistently, overexpression of Grb2 resulted in decreased Nox1 activity, whereas knockdown of Grb2 led to increased Nox1 activity in response to EGF. CRISPR/Cas9-mediated NoxO1 knockout in human colon cancer cells abrogated anchorage-independent growth on soft agar and tumor-forming ability in athymic nude mice. Moreover, the expression and stability of NoxO1 were significantly increased in human colon cancer tissues compared with normal colon. Taken together, these results support a model whereby Nox1 activity and ROS generation are regulated by Grb2/Cbl-mediated proteolysis of NoxO1 in response to EGF, providing new insight into the processes by which excessive ROS production may promote oncogenic signaling to drive colorectal tumorigenesis.
Output: Which NADPH oxidase family member requires interaction with NOXO1 for function?
David T. Friendly (born May 1, 1956) is an American film producer best known for co-producing the 2006 film Little Miss Sunshine, for which he was nominated for an Academy Award for Best Picture.
Output: What award was David T. Friendly nominated for?
Lysyl oxidase-like 2 (LOXL2) catalyses collagen cross-linking and is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the efficacy and safety of simtuzumab, a monoclonal antibody against LOXL2, in patients with IPF. In this randomised, double-blind, phase 2 trial, we recruited patients aged 45-85 years with definite IPF diagnosed prior to 3 years of screening from 183 hospitals and respiratory clinics in 14 countries. Eligible patients, stratified by baseline forced vital capacity (FVC), serum LOXL2 (sLOXL2) concentrations, and pirfenidone and nintedanib use, were randomly assigned (1:1) to inject 125 mg/mL simtuzumab or placebo subcutaneously once a week. The primary endpoints were progression-free survival, defined as time to all-cause death or a categorical decrease from baseline in FVC % predicted, in the intention-to-treat population, in patients with sLOXL2 concentrations in the 50th percentile or higher, and in patients with sLOXL2 concentrations in the 75th percentile or higher. Treatment duration was event-driven, and interim analyses were planned and conducted after approximately 120 and 200 progression-free survival events, respectively, occurred. We compared treatment groups with the stratified log-rank test. This study is registered with ClinicalTrials.gov, number NCT01769196. Patients with IPF were recruited between Jan 31, 2013, and June 1, 2015. The intention-to-treat population included 544 randomly assigned patients (272 patients in both groups), and the safety population included 543 randomly assigned patients who received at least one dose of study medication. The study was terminated when the second interim analysis met the prespecified futility stopping criteria in the intention-to-treat population. We noted no difference in progression-free survival between simtuzumab and placebo in the intention-to-treat population (median progression free survival times of 126 months and 154 months for simtuzumab and placebo, respectively; stratified HR 113, 95% CI 088-145; p=0329) and in patients with baseline sLOXL2 in the 50th percentile or higher (median progression-free survival 117 months and 143 months for simtuzumab and placebo, respectively; stratified HR 103, 95% CI 074-143; p=0851), or in the 75th percentile or higher (median progression-free survival 116 months and 169 months for simtuzumab and placebo, respectively; stratified HR 120, 95% CI 072-200; p=0475). The incidence of adverse events and serious adverse events was similar between treatment groups. The most common adverse events in both the simtuzumab and placebo groups were dyspnoea, cough, upper respiratory tract infection, and worsening of IPF; and the most common grade 3 or 4 adverse events were worsening of IPF, dyspnoea, and pneumonia. Simtuzumab did not improve progression-free survival in a well-defined population of patients with IPF. Our data do not support the use of simtuzumab for patients with IPF. Gilead Sciences Inc.
Output: What is the drug target for Simtuzumab?
Glen Seabrooke (born September 11, 1967) is a retired Canadian professional ice hockey player who spent parts of 3 seasons in the National Hockey League (NHL) in the 1980s with the Philadelphia Flyers.
Output: What team is Glen Seabrooke on?
In Hawaiian mythology, Namaka (or Na-maka-o-Kahai, the eyes of Kahai) appears as a sea goddess or a water spirit in the Pele cycle.
Output: Who is Nāmaka's sister?
Fish species are expected to shrink in size by up to 24% because of global warming, say scientists. The scientists argue that failure to control greenhouse gas emissions will have a greater effect on marine ecosystems than previously thought. Previous research has suggested that changing ocean temperatures would affect both the distribution and the reproductive abilities of many species of fish. This new work suggests that fish size would also be heavily affected. The researchers built a model to see how fish would react to lower levels of oxygen in the water. As ocean temperatures increase, so do the body temperatures of fish. But, according to lead author, Dr William Cheung, from the University of British Columbia, the lower level of oxygen in the water is key. Warmer waters could decrease ocean oxygen levels and greatly reduce fish body weight. On the other hand, rising temperatures directly increase the metabolic rate of the fish's body function. This leads to an increase in oxygen demand for normal body activities. So the fish will run out of oxygen for growth at a smaller body size. The research team also used its model to predict fish movements as a result of warming waters. The group believes that most fish populations will move towards the Earth's poles at a rate of up to 35km per decade. "So in, say, the North Sea," says Dr Cheung," one would expect to see more smaller-body fish from tropical waters in the future." Taking these factors into consideration, the research team concludes that fish body size will shrink between 14% and 24%, with the largest decreases in the Indian and Atlantic oceans. When compared with actual observations of fish sizes, the model seems to _ what's actually happening in the seas. The researchers looked at two case studies involving North Atlantic cod and haddock. They found that recorded data on these fish showed greater decreases in body size than the models had predicted. Dr Alan Baudron, from the University of Aberdeen, UK, believes smaller-sized fish could seriously affect the ability of fish to reproduce. "Smaller fish produce fewer and smaller eggs which could affect the reproductive potential of fish stocks," he said.
Output: What is the key factor making the fish smaller now?
The Minnesota River is a tributary of the Mississippi River, approximately 332 miles (534 km) long, in the U.S. state of Minnesota.
Output: Of what river is Minnesota River a tributary?
The Angels first take note of "Poet" (Jack Nicholson) after one of them inadvertently damages his motorcycle and breaks its headlight. Poet, with far more guts than brains, challenges the Angel that hit his motorcycle. This is an act that would traditionally result in every Angel present participating in a group beating of the attacker. "When a non-Angel hits an Angel, all Angels retaliate." But the leader of the Angels, Buddy (Adam Roarke), intervenes and tells Poet that the Angels will replace the headlight. In the meantime, he's welcome to ride with them while they take care of businesswhich turns out to be going to a bar and beating up the members of another club who previously beat an Angel. Poet is told to wait outside, but ends up helping the Angels. Later that night, the Angels return the favor by hunting down and beating four sailors who beat Poet four-against-one after he parted company with the group. Poet accidentally bumps into one of the sailors and speaks rudely to him before he realizes that the sailor has three other sailors with him. The four sailors then refuse to accept his apologybut the Angels only know that four sailors beat up Poet, and he doesn't tell them how the earlier fight started. One of the sailors pulls a knife on the Angels and is then killed accidentally in the fight that follows. Poet is allowed to ride with the Angels and is eventually elevated to "prospect" status. He is attracted to Buddy's some-time girlfriend (Sabrina Scharf) who toys with him while remaining hopelessly committed to Buddy. Much of the story that follows consists of scenes of the Angels partying or being provoked to violence by "squares." Although the Angels are shown as being loud and generally irreverent, they are never shown starting trouble except when taking revenge on members of other motorcycle clubs. Eventually, Buddy's girlfriend succeeds in provoking a confrontation between Buddy and Poet with only one surviving.
Output: Who loves the same woman as Poet?
The McLeod phenotype is derived from various forms of XK gene defects that result in the absence of XK protein, and is defined hematologically by the absence of Kx antigen, weakening of Kell system antigens, and red cell acanthocytosis. Individuals with the McLeod phenotype usually develop late-onset neuromuscular abnormalities known as the McLeod syndrome (MLS). MLS is an X-linked multi-system disorder caused by absence of XK alone, or when the disorder is caused by large deletions, it may be accompanied with Duchenne muscular dystrophy (DMD), chronic granulomatous disease (CYBB), retinitis pigmentosa (RPGR), and ornithine transcarbamylase deficiency (OTC). XK defects derived from a large deletion at the XK locus (Xp21.1) have not been characterized at the molecular level. In this study, the deletion breakpoints of two novel cases of McLeod phenotype with extensive deletions are reported. Case 1 has greater than 1.12 million base-pairs (mb) deletion around the XK locus with 7 genes affected. Case 2 has greater than 5.65 mb deletion from TCTE1L to DMD encompassing 20 genes. Phylogenetic analyses demonstrated that DMD, XK and CYBB have close paralogs, some of which may partially substitute for the functions of their counterparts. The loci around XK are highly conserved from fish to human; however, the disorders are probably specific to mammals, and may coincide with the translocation of the loci to the X chromosome after the speciation in birds. The non-synonymous to synonymous nucleotide substitution rate ratio (omega=dN/dS) in these genes was examined. CYBB and RPGR show evidence of positive selection, whereas DMD, XK and OTC are subject to selective constraint.
Output: Mutation of which gene is associated with McLeod syndrome?
The direct thrombin inhibitor dabigatran and the anti-Xa agents rivaroxaban, edoxaban, and apixaban are a new generation of oral anticoagulants. Their advantage over the vitamin K antagonists is the lack of the need for monitoring and dose adjustment. Their main disadvantage is currently the absence of a specific reversal agent. Dabigatran's, unlike the anti-Xa agents, absorption can be reduced by activated charcoal if administered shortly after ingestion and it can be removed from the blood with hemodialysis. Prothrombin complex concentrate, activated prothrombin complex concentrate, and recombinant factor VIIa all show some activity in reversing the anticoagulant effect of these drugs but this is based on ex vivo, animal, and volunteer studies. It is unclear, which, if any, of these drugs is the most suitable for emergency reversal. Three novel molecules (idarucizumab, andexanet, and PER977) may provide the most effective and safest way of reversal. These agents are currently in premarketing studies.
Output: Idarucizumab is an antidote of which drug?
Mutations of the alpha-synuclein gene have shown to be relevant in some rare families with autosomal dominant Parkinson's disease (PD). Furthermore, alpha-synuclein protein is a major component of the Lewy bodies also in sporadic PD patients. Increased levels of wildtype alpha-synuclein in the cell leads to increased intracellular hydrogen peroxide levels and causes death of dopaminergic neurons in rat primary culture. Subsequently, oxidative stress has been directly linked with alpha-synuclein aggregation in vitro. This raises the question whether increased alpha-synuclein expression might be linked to higher susceptibility to PD and whether alpha-synuclein promoter polymorphisms are associated with PD. Here, two polymorphisms (-116C>G and -668T>C) of the alpha-synuclein promoter defining four haplotypes have been characterized in 315 German PD patients. The influence of the four haplotypes on gene expression was studied by CAT reporter gene assays in neuronal SK-N-AS cells. The -668C/-116G haplotype revealed significant higher CAT expression than the -668T/-116G or the -668T/-116C haplotype, respectively. Although the -668C/-116G haplotype was more common in PD patients, this difference was not significant.
Output: Which is the primary protein component of Lewy bodies?
Terra-cotta Warriors As the greatest archaeological findings of the 20th century, Terra-cotta Warriors has a really long history.In 246 BC, Qin Shi Huang, later the first Emperor of all China, had begun to prepare for his mausoleum which took 11 years to finish to defend him in the afterlife.There are over 7,000 pottery soldiers, horses, bronze chariots, and even weapons found in it now.Terra-cotta Warriors was listed by UNESCO in 1987 as one of the world cultural heritages and it has made Xi'an a famous city for tourists. Big Wild Goose Pagoda The Big Wild Goose Pagoda has a history of over 1,300 years and is a typical ancient Chinese building.It is located in the south of Xi'an City.Because Master Xuanzang stored his classics brought from India in the pagoda, it is also a holy place for Buddhists.As a National Key Cultural Relic Preserve, it won the title of an AAAA Tourist Attraction as well. Xi'an Ancient City Wall As one of the landmarks of Xi'an, Ancient City Wall still stretches round the old city today, dividing the city into the inner part and the outer part.Ancient City Wall was originally built during the old Tang Dynasty (618 -- 907) and then enlarged by Zhu Yuanzhang, Emperor of the Ming Dynasty, thus forming the modern Xi'an City Wall.After the extension, the wall now stands 12 meters tall, 12-14 meters wide at the top and 15-18 meters thick at the bottom.
Output: Who are the text written for?
Growth in 2000-05 was supported by exports to the EU, primarily to Germany, and a strong recovery of foreign and domestic investment. Domestic demand is playing an ever more important role in underpinning growth as interest rates drop and the availability of credit cards and mortgages increases. Current account deficits of around 5% of GDP are beginning to decline as demand for Czech products in the European Union increases. Inflation is under control. Recent accession to the EU gives further impetus and direction to structural reform. In early 2004 the government passed increases in the Value Added Tax and tightened eligibility for social benefits with the intention to bring the public finance gap down to 4% of GDP by 2006, but more difficult pension and healthcare reforms will have to wait until after the next elections. Privatization of the state-owned telecommunications firm Cesky Telecom took place in 2005. Intensified restructuring among large enterprises, improvements in the financial sector, and effective use of available EU funds should strengthen output growth.
Output: What does EU stand for?
The glycoprotein sclerostin (Scl; 22 kDa), which is involved in bone metabolism, may play a role in vascular calcification in haemodialysis (HD) patients. In the present study, we investigated the relation between serum Scl (sScl) and mortality. The effects of dialysis modality and the magnitude of the convection volume in haemodiafiltration (HDF) on sScl were also investigated. In a subset of patients from the CONTRAST study, a randomized controlled trial comparing HDF with HD, sScl was measured at baseline and at intervals of 6, 12, 24 and 36 months. Patients were divided into quartiles, according to their baseline sScl. The relation between time-varying sScl and mortality with a 4-year follow-up period was investigated using crude and adjusted Cox regression models. Linear mixed models were used for longitudinal measurements of sScl. The mean (standard deviation) age of 396 test subjects was 63.6 (13.9 years), 61.6% were male and the median follow-up was 2.9 years. Subjects with the highest sScl had a lower mortality risk than those with the lowest concentrations [adjusted hazard ratio 0.51 (95% confidence interval, CI, 0.31-0.86, P = 0.01)]. Stratified models showed a stable sScl in patients treated with HD ( +2.9 pmol/L/year, 95% CI -0.5 to +6.3, P = 0.09) and a decreasing concentration in those treated with HDF ( -4.5 pmol/L/year, 95% CI -8.0 to -0.9, P = 0.02). The relative change in the latter group was related to the magnitude of the convection volume. (i) A high sScl is associated with a lower mortality risk in patients with end-stage kidney disease; (ii) treatment with HDF causes sScl to fall; and (iii) the relative decline in patients treated with HDF is dependent on the magnitude of the convection volume.
Output: Sclerostin regulates what process?
Viroids, satellite RNAs, satellites viruses and the human hepatitis delta virus form the 'brotherhood' of the smallest known infectious RNA agents, known as the subviral RNAs. For most of these species, it is generally accepted that characteristics such as cell movement, replication, host specificity and pathogenicity are encoded in their RNA sequences and their resulting RNA structures. Although many sequences are indexed in publicly available databases, these sequence annotation databases do not provide the advanced searches and data manipulation capability for identifying and characterizing subviral RNA motifs. The Subviral RNA database is a web-based environment that facilitates the research and analysis of viroids, satellite RNAs, satellites viruses, the human hepatitis delta virus, and related RNA sequences. It integrates a large number of Subviral RNA sequences, their respective RNA motifs, analysis tools, related publication links and additional pertinent information (ex. links, conferences, announcements), allowing users to efficiently retrieve and analyze relevant information about these small RNA agents. With its design, the Subviral RNA Database could be considered as a fundamental building block for the study of these related RNAs. It is freely available via a web browser at the URL: [Link]
Output: Which are the smallest known subviral pathogens of plants?
The War of the Spanish Succession ended with the Treaty of Utrecht in 1713. The colonial borders of northeastern North America were reshaped as a result, but the treaty did not account for Indian claims to the same area. French Acadia was ceded to Great Britain which established the province of Nova Scotia, although its borders were disputed. The area disputed by the European powers consisted of land between the Kennebec River and the Isthmus of Chignecto . This land was occupied by a number of Algonquian-speaking Indian tribes loosely allied in the Wabanaki Confederacy, which also claimed sovereignty over most of this territory and had occupancy preceding that of the Colonists. Massachusetts Governor Joseph Dudley organized a major peace conference at Portsmouth, New Hampshire. In negotiations there and at Casco Bay, the Wabanaki present orally objected to British assertions that the French had ceded their territory to Britain in eastern Maine and New Brunswick, and agreed to a confirmation of boundaries at the Kennebec River and the establishment of government-run trading posts in their territory.:162-163 The Treaty of Portsmouth was ratified on July 13, 1713 by eight representatives of the Wabanaki Confederacy, however, which asserted British sovereignty over their territory.:107-110 Over the next year, other Abenaki tribal leaders also signed the treaty, but no Mi'kmaq ever signed it or any other treaty until 1726.:97-98
Output: Which treaty came first the Treaty of Utrecht or the Treaty of Portsmouth?
Sometimes, the urinary system ( Figure 1.1) is called the excretory system. But the urinary system is only one part of the excretory system. Recall that the excretory system is also made up of the skin, lungs, and large intestine, as well as the kidneys. The urinary system is the organ system that makes, stores, and gets rid of urine. 1. As you can see above ( Figure 1.1), the kidneys are two bean-shaped organs. Kidneys filter and clean the blood and form urine. They are about the size of your fists and are found near the middle of the back, just below your ribcage. 2. Ureters are tube-shaped and bring urine from the kidneys to the urinary bladder. 3. The urinary bladder is a hollow and muscular organ. It is shaped a little like a balloon. It is the organ that collects urine. 4. Urine leaves the body through the urethra. The kidneys filter the blood that passes through them, and the urinary bladder stores the urine until it is released from the body. Urine is a liquid that is formed by the kidneys when they filter wastes from the blood. Urine contains mostly water, but it also contains salts and nitrogen-containing molecules. The amount of urine released from the body depends on many things. Some of these include the amount of fluid and food a person consumes and how much fluid they have lost from sweating and breathing. Urine ranges from colorless to dark yellow but is usually a pale yellow color. Light yellow urine contains mostly water. The darker the urine, the less water it contains. The urinary system also removes a type of waste called urea from your blood. Urea is a nitrogen-containing molecule that is made when foods containing protein, such as meat, poultry, and certain vegetables, are broken down in the body. Urea and other wastes are carried in the bloodstream to the kidneys, where they are removed and form urine.
Output: which organ is not part of the urinary system?
Membrane antigens are critical to the pathogenesis of chronic lymphocytic leukemia (CLL) as they facilitate microenvironment homing, proliferation, and survival. Targeting the CLL membrane and associated signaling patterns is a current focus of therapeutic development. Many tumor membrane targets are simultaneously targeted by humoral immunity, thus forming recognizable immunoglobulin responses. We sought to use this immune response to identify novel membrane-associated targets for CLL. Using a novel strategy, we interrogated CLL membrane-specific autologous immunoglobulin G reactivity. Our analysis unveiled lymphocyte cytosolic protein 1 (LCP1), a lymphocyte-specific target that is highly expressed in CLL. LCP1 plays a critical role in B-cell biology by crosslinking F-actin filaments, thereby solidifying cytoskeletal structures and providing a scaffold for critical signaling pathways. Small interfering RNA knockdown of LCP1 blocked migration toward CXCL12 in transwell assays and to bone marrow in an in vivo xenotransplant model, confirming a role for LCP1 in leukemia migration. Furthermore, we demonstrate that the Bruton's tyrosine kinase inhibitor ibrutinib or the PI3K inhibitor idelalisib block B-cell receptor induced activation of LCP1. Our data demonstrate a novel strategy to identify cancer membrane target antigens using humoral anti-tumor immunity. In addition, we identify LCP1 as a membrane-associated target in CLL with confirmed pathogenic significance. This clinical trial was registered at clinicaltrials.gov; study ID number: OSU-0025 OSU-0156.
Output: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?
Maria Schalcken (1645 -- 1699), was a Dutch Golden Age painter, sister and pupil of Godfried Schalcken.
Output: Who was the brother of Maria Schalcken?
Normal B lymphocytes receive signals from B-cell antigen receptor (BCR) that are triggered by binding of the BCR to an external antigen. Tonic signaling through the BCR provides growth and signals to chronic lymphocytic leukemia (CLL) cells, and plays an important role in the pathogenesis and progression of the disease. Antigen engagement of BCR is followed by intracellular recruitment and activation of BCR-associated kinases including spleen tyrosine kinase (Syk), Bruton's tyrosine kinase (Btk) and phosphatidylinositol 3-kinases (PI3K). Inhibition of signaling pathways downstream of the BCR induces disruption of chemokine-mediated CLL cell migration and cell killing. BCR signal transduction inhibitors represent a promising new strategy for targeted CLL treatment. A number of therapeutic agents have recently been developed with significant activity in CLL. The compounds that are currently investigated in patients with CLL include ibrutinib -inhibitor of Btk, fostamatinib-inhibitor of Syk and idelalisib (GS-1101) -a specific isoform of the PI3K (PI3K) inhibitor. The clinical activity of ibrutinib, GS-1101 and fostamatinib in patients with CLL is associated with marked lymphocytosis due to release of tumor cells from the lymph nodes into the peripheral blood. Further studies are ongoing with single agents and their combinations with other targeted and conventional therapies. This article will review the preclinical rationale of BCR signaling inhibitors in the treatment of CLL, and the clinical evidence supporting the use of these agents in CLL patients.
Output: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?
Trimethylation of histone H3 Lys4 (H3K4) is associated with transcriptional activation. One of the chief effectors of H3K4 methylation is mixed-lineage leukemia 1 (MLL1), a gene that is disrupted by chromosomal translocation in acute leukemia and a master regulator of Hox and other genes. In a recent paper, core components of the human MLL histone methyltransferase (MT) complex were found to form a structural platform, with one component (WDR5) mediating association between the specific histone H3K4 substrate and the MT. This novel regulatory mechanism, which is conserved from yeast to human, is required for both methylation and downstream target gene transcription.
Output: Which is the histone residue methylated by MLL1?