niryuu/sni-each-converted huggingface dataset:
Mutations in solute carrier family 9 isoform 6 on chromosome Xq26.3 encoding sodium-hydrogen exchanger 6, a protein mainly expressed in early and recycling endosomes are known to cause a complex and slowly progressive degenerative human neurological disease. Three resulting phenotypes have so far been reported: an X-linked Angelman syndrome-like condition, Christianson syndrome and corticobasal degeneration with tau deposition, with each characterized by severe intellectual disability, epilepsy, autistic behaviour and ataxia. Hypothesizing that a sodium-hydrogen exchanger 6 deficiency would most likely disrupt the endosomal-lysosomal system of neurons, we examined Slc9a6 knockout mice with tissue staining and related techniques commonly used to study lysosomal storage disorders. As a result, we found that sodium-hydrogen exchanger 6 depletion leads to abnormal accumulation of GM2 ganglioside and unesterified cholesterol within late endosomes and lysosomes of neurons in selective brain regions, most notably the basolateral nuclei of the amygdala, the CA3 and CA4 regions and dentate gyrus of the hippocampus and some areas of cerebral cortex. In these select neuronal populations, histochemical staining for -hexosaminidase activity, a lysosomal enzyme involved in the degradation of GM2 ganglioside, was undetectable. Neuroaxonal dystrophy similar to that observed in lysosomal disease was observed in the cerebellum and was accompanied by a marked and progressive loss of Purkinje cells, particularly in those lacking the expression of Zebrin II. On behavioural testing, Slc9a6 knockout mice displayed a discrete clinical phenotype attributable to motor hyperactivity and cerebellar dysfunction. Importantly, these findings show that sodium-hydrogen exchanger 6 loss of function in the Slc9a6-targeted mouse model leads to compromise of endosomal-lysosomal function similar to lysosomal disease and to conspicuous neuronal abnormalities in specific brain regions, which in concert could provide a unified explanation for the cellular and clinical phenotypes in humans with SLC9A6 mutations.
Output: Mutation of which gene is implicated in the Christianson syndrome?
HD 27245 is a variable red giant star in the northern constellation of Camelopardalis.
Output: What constellation is HD 27245 in?
Caroline Tresca was born in Angers in the department of Maine-et-Loire.
Output: What is the birth place of  Caroline Tresca?
If you are a high school senior graduating and looking to enter college in 2006, you will take the new exam. The biggest change to the SAT will be the introduction of a new writing section. The writing section will consist of two parts: an essay and a multiple-choice section. Students will be given 25 minutes to respond to a prompt and construct a well-organized essay that effectively deals with the task. The essay question may require students to complete a statement, to react to a quote, or to agree or disagree with a point of view. In any case, a good essay will support the chosen position with specific reasons and examples from literature, history, art, science, current affairs, or even a student's own experiences. Essays will be scored based on the procedures for the current SAT II: Writing Test. Essays will be graded by two independent readers On a scale of 1~6, and their two scores will be combined to form an essay subscore that ranges from 2 to 12. Should the readers' scores vary by more than 2 points, a third reader will score the essay; The readers will be high school teachers and college professors who teach composition. To ensure that essays will be scored in a timely manner, they will be scanned and made available to readers on the Internet for grading purpose. The writing section will also include multiple-choice grammar and usage questions. Some of these questions will call upon students to improve given sentences and paragraphs. Others will present students with sentences and require them to identify mistakes in diction , grammar, sentence construction, subject-verb agreement, proper word usage. The highest possible score on the new writing section will be 800. Scores on the essay and multiple-choice section will be combined to produce a single score. A writing subscore will also be assigned. The highest possible scores on the Critical Reading and Math sections will remain 800 each, making 2,400 a perfect score on the new SAT.
Output: Which parts are included in the writing section of SAT according to the passage?
A dentist's office may not be everyone's idea of a perfect holiday destination.But a growing number of Europeans are travelling abroad for medical treatment to save money,or maybe to combine a visit to the doctor with some sightseeing,creating a potential but fastgrowing market for traditional tour operators. "It was simply cheaper for me to go to a dentist in Hungary," said a 42yearold physical therapist from Berlin.He chose the clinic near Budapest from an Internet advertisement,attracted by hundreds of euros in savings compared with the same treatment in Germany.He was happy to find when he got there that the clinic was clean,the staff qualified and the work thorough. People travel abroad for medical treatment for various reasons:it's cheaper,they face a long wait at home,or the treatment they want is not available in their own country.The Britishbased Medical Tourist Company refers about 100 patients a year to hospitals in India for treatments.And Chief Executive Premhar Shah reports rapid growth in demand from customers in Africa,where it can be harder to find wellequipped medical facilities for complex surgeries. Some patients who have immigrated may prefer to return to be close to their families when they undergo surgery."People will want to take the opportunity to seek treatment in places where they have relatives who might be able to look after them.I'm seeing that especially with younger people from eastern Europe," said a professor at the University of Oxford. For some,there is the attraction of free treatment abroad.British lawmakers have called for tighter checks on patients arriving for treatment,out of concerns that foreign citizens are travelling to Britain to take advantage of the free service. The global medical tourism market is believed to be worth $40 billion to $60 billion and growing at about 20 percent per year.
Output: What does the article mainly talk about?
Loma just had to get in touch with someone:"I had to tell my best friend something important. I tried calling her but I couldn't get through. So I sent her an e-mail and then I spoke to her on MSN. Without technology I would not have been able to tell her. " Staying connected with friends and family is important for us. That's why we asked our readers to tell us how cell-phones, e-mail, blogs, text messaging, and personal pages help them keep in touch. More than 1,500 responded. Most of them told us they couldn't live without technology:80%of teens said they need technology to stay in touch. Almost 30%said they'd be completely out of their friends without their cell-phones and other methods of communication. What do they do when they've got news they need to share now? Most teens say they try to reach their friends by phone. But if they don't reach them, they use QQ, e-mails, and text messaging to _ Lots of people use one way of communication--like text messaging--to get a friend's attention and then use another where they can talk more. "My friends and I always tell each other everything that happens. So I send them text messages to tell them to come online so we can talk about it," said Sabeiha. "When planning to get together with friends", Julian said, "the easiest and fastest way I know is to send a text message to my contact group." Jocelyn said. "If I want to go to see a movie with a few friends, I usually send text message to them. By telephone, you have to call every single friend one by one. But text messaging allows you to send the same message to as many as you'd like, which saves a lot of time.
Output: What do most young people use first when they have news to tell their friends?
Embryonic neuroepithelia and adult subventricular zone (SVZ) stem and progenitor cells express nestin. We characterized a transgenic line that expresses enhanced green fluorescent protein (eGFP) specified to neural tissue by the second intronic enhancer of the nestin promoter that had several novel features. During embryogenesis, the dorsal telencephalon contained many and the ventral telencephalon few eGFP+ cells. eGFP+ cells were found in postnatal and adult neurogenic regions. eGFP+ cells in the SVZ expressed multiple phenotype markers, glial fibrillary acidic protein, Dlx, and neuroblast-specific molecules suggesting the transgene is expressed through the lineage. eGFP+ cell numbers increased in the SVZ after cortical injury, suggesting this line will be useful in probing postinjury neurogenesis. In non-neurogenic regions, eGFP was strongly expressed in oligodendrocyte progenitors, but not in astrocytes, even when they were reactive. This eGFP+ mouse will facilitate studies of proliferative neuroepithelia and adult neurogenesis, as well as of parenchymal oligodendrocytes.
Output: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
James R. Redmond is Emeritus Professor of Zoology in the Iowa State University department of Ecology, Evolution and Organismal Biology.
Output: What is James R. Redmond's place of employment?
Diocletian's Palace (Croatian: Dioklecijanova palaca, pronounced (dikltsijana palata)) is an ancient palace built by the Roman emperor Diocletian at the turn of the fourth century AD, that today forms about half the old town and city center of Split, in Croatia.
Output: What city is the band Diocletian's Palace from?
James Dargaville (born 25 April 1992) is an Australian rugby union footballer who currently plays as a wing for the Brumbies in Super Rugby.
Output: What is the position James Dargaville plays in football?
The most popular names in the west Every year in Englishspeaking countries,people list the most popular names. Here are some examples. In the United States at the moment the three most popular names for girls are Emily,Emma and Madison. For boys,they are Michael,Joshua and Mathew. In Britain a parent today might call their little girl Grace,Jessica or Ruby. If they have a little boy they could call him Jack,Thomas or Oliver. In China names have very clear meanings. If a girl is called Mei,her name means "beautiful". If a boy is called Wu,his name means "like a soldier". Names in Englishspeaking countries are like this too. The girl's name Joy is probably partly chosen because the parents wish their daughter to be joyful and bring joy to others. If a girl is called Ruby,it may be because of the beautiful red precious stone. Parents often pick names that can be shortened. This can be confusing for Chinese people. Parents might choose such names because they want to be able to speak to their kid in a personal way. For example,a popular name is William. But William can be shortened to Will,Willy,Bill and Billy. The same is true of the favourite old name for a girl,Elizabeth. Elizabeth can be shortened to Beth,Liza and Liz. Another reason why kids get the names they do is that parents want to name their boy or girl after someone who is famous,such as an actor,a pop music star or a sports star. David is a popular name in Britain,partly because of the fame of the footballer David Beckham.
Output: Which name may have something to do with "gladness"?
We're always looking for well-written reviews of books, music, movies, television shows, websites, video games and other products. When writing a review, concentrate on exactly what you liked or didn't like. Give examples of strengths and weaknesses, be descriptive and provide background information on an author, director, actor or musician, if possible. Find professional reviews in magazines or newspapers and see how reviewers deal with their topic, but be sure to express your own voice in your review. Grammar Hint for Reviews: When describing a book, movie, album or anything else, use the present tense. Book Reviews Discuss an author's technique, strengths and weaknesses instead of focusing on the plot. Does the story flow? Is there a strong sense of character and place? Did you stay up until dawn to finish it? Is it good reading for teenagers? What influence did it have on you and why? If you've read other books by the same author, discuss how this book compares. Movie Reviews Think of the major Oscar categories and consider the performances, music, lighting and setting, etc. Do these work together? Did some hold up while others didn't? If the movie is based on a book, discuss whether one is better than the other and why. If the movie is a remake, compare the film to its original. Remember that a well-written movie review should discuss strengths and weaknesses. Some readers may not have seen a movie yet, so don't give away an exciting scene or the ending! College Reviews Begin by providing an overview of the college, including location, size and a description of the campus and/or dorm life. Think about all aspects of your college visit. What academic, athletic and after-class programs are available? What are the students like? What makes the college different from others? Every school has strengths and weaknesses. Be objective. Consider what the school has to offer and who might enjoy or benefit the most from attending there.
Output: Which aspects should be included in all three reviews?
The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) on the Na+-Ca2+ exchanger (NCX) was investigated and compared against that of 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943). In addition, the effects of SEA0400 on reperfusion injury in vitro and in vivo were examined. SEA0400 was extremely more potent than KB-R7943 in inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia: IC50s of SEA0400 and KB-R7943 were 5 to 33 nM and 2 to 4 microM, respectively. SEA0400 at the concentration range that inhibited NCX exhibited negligible affinities for the Ca2+ channels, Na+ channels, K+ channels, norepinephrine transporter, and 14 receptors, and did not affect the activities of the Na+/H+ exchanger, Na+,K+-ATPase, Ca2+-ATPase, and five enzymes. SEA0400, unlike KB-R7943, did not inhibit the store-operated Ca2+ entry in cultured astrocytes. SEA0400 attenuated dose- dependently paradoxical Ca2+ challenge-induced production of reactive oxygen species, DNA ladder formation, and nuclear condensation in cultured astrocytes, whereas it did not affect thapsigargin-induced cell injury. Furthermore, administration of SEA0400 reduced infarct volumes after a transient middle cerebral artery occlusion in rat cerebral cortex and striatum. These results indicate that SEA0400 is the most potent and selective inhibitor of NCX, and suggest that the compound may exert protective effects on postischemic brain damage.
Output: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
Some missense mutations and small deletions in the NOTCH3 gene, not involving cysteine residues, have been described in patients considered to be affected by paucisymptomatic CADASIL. However, the significance of such molecular variants is still unclear. We describe a 49-year-old woman with a CADASIL-like phenotype, carrying a novel cysteine-sparing mutation in exon 29 of the NOTCH3 gene, and discuss the possible pathogenetic role of this molecular variant. Even though atypical clinical and MRI findings make a diagnosis of CADASIL unlikely in this patient, our report nevertheless underlines the intriguing genotype-phenotype relationship in NOTCH3 mutations and the importance of functional investigation to ascertain the role of new NOTCH3 mutations in CADASIL pathogenesis.
Output: Which amino acid residue appears mutated in most of the cases reported with  cadasil syndrome?
Dasatinib (BMS-354825) is a Src/ABL tyrosine kinase inhibitor currently approved for the treatment of chronic myeloid leukemia. Dasatinib has increased potency against ABL compared to the current therapy imatinib, and is effective in many cases where disease is resistant to imatinib. Dasatinib also inhibits many Src-family tyrosine kinases. We have demonstrated in this study that dasatinib is able to block the function of normal human T-lymphocytes in vitro at clinically relevant concentrations. T-cell functions including proliferation, activation and cytokine production were all uniformly inhibited in the presence of dasatinib. We also demonstrated inhibition of TCR signalling through Src-family kinase LCK, and predicted that inhibition of LCK and other kinases involved in T-cell signalling by dasatinib is responsible for the suppression of T-cell function. These findings raise the concern about potential T-cell inhibition in patients taking dasatinib, and suggest a possible application for the treatment of T-cell mediated immune disorders.
Output: Does dasatinib promote or inhibit T-cell proliferation?
The aim of this study was to analyze complications of vestibular schwannoma (VS) microsurgery. A retrospective study was performed in 333 patients with unilateral vestibular schwannoma indicated for surgical treatment between January 1997 and December 2012. Postoperative complications were assessed immediately after VS surgery as well as during outpatient followup. In all 333 patients microsurgical vestibular schwannoma (Koos grade 1: 12, grade 2: 34, grade 3: 62, and grade 4: 225) removal was performed. The main neurological complication was facial nerve dysfunction. The intermediate and poor function (HB III-VI) was observed in 124 cases (45%) immediately after surgery and in 104 cases (33%) on the last followup. We encountered disordered vestibular compensation in 13%, permanent trigeminal nerve dysfunction in 1%, and transient lower cranial nerves (IX-XI) deficit in 6%. Nonneurological complications included CSF leakage in 63% (lateral/medial variant: 99/1%), headache in 9%, and intracerebral hemorrhage in 5%. We did not encounter any case of meningitis. Our study demonstrates that despite the benefits of advanced high-tech equipment, refined microsurgical instruments, and highly developed neuroimaging technologies, there are still various and significant complications associated with vestibular schwannomas microsurgery.
Output: Which disease can be categorized using the Koos grading system?
In 2011, Macaus free-market economy produced total exports of US$1.119 billion (MOP 8.94 billion) and consisted mainly of clothing, textiles, footwear, toys, electronics, machinery and parts. Total imports for the same period reached US$8.926 billion (MOP 71.32 billion), and consisted mostly of raw materials and semi-manufactured goods, consumer goods (foodstuffs, beverages, tobacco), capital goods, mineral fuels and oils. Macaus primary export partner in 2011 was Hong Kong (44.6%). Other exports go to Mainland China (15.9%) and United States (7.9%). Macau import partners are Mainland China (30.4%), Hong Kong (12%), France (10.4%), Switzerland (7.5%), Italy (7.5%), Japan (6.2%), and United States (6.1%).
Output: Where does Macau import more products from, France or Italy?
Sharman Douglas died of bone cancer at New York Hospital in 1996.
Output: What medical condition killed Sharman Douglas?
The President of the European Parliament (Parliament's speaker) is Martin Schulz (S&D), elected in January 2012.
Output: Who led European Parliament?
In a brief period between World War I and World War II the Kingdom of Yugoslavia, successor to the Kingdom of Serbia, formed a ''Small Entente'' loose union between Czechoslovakia, Romania and Yugoslavia.
Output: Which replaced the Kingdom of Serbia?
You may know your mother, but how well do you really know Mothers' Day? Cards, flowers, sales, TV specials, and a day off for someone who really deserves it -- those are what probably come to mind for many people when they think of Mothers' Day. But there's more to the story. The earliest Mothers' Day celebrations were held during spring in ancient Greece. The celebrations honored Rhea, the mother of the gods. During the 1600's, England celebrated a day called Mothering Sunday. On this day even servants were given the day off to spend with their families. A mothering cake was even served with the family meal. In the US, Mothers' Day began in 1872 when Julia Ward Howe, who wrote the words to the famous song The Battle Hymn of the Republic, suggested it as a day devoted to peace. But it didn't really become popular until 1907 when Anna Jarvis started a campaign to honor mothers. She believed that mothers could help people get over the pain they experienced during the Civil War. The US isn't alone in devoting a day to mothers. Many other countries including Denmark, Finland, Italy, Turkey, Australia, Japan, and Belgium also honor their mothers in May. Other countries honor their mothers at different times of the year. Learning more about Mothers' Day and celebrating Mothers' Day are important, but probably not as important as understanding what your own mother, or grandmother, or aunt has really done for you. And that will certainly be appreciated more than one day in year.
Output: Where was the earliest Mothers' Day celebrated?
Clathrodrillia walteri is a species of sea snail, a marine gastropod mollusk in the family Drilliidae.
Output: Is the taxon rank of Clathrodrillia walteri species or genus?
Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder, caused by an expansion of a CTG triplet repeat in the DMPK gene. The aims of the present study were to classify a cohort of children with DM1, to describe their neuropsychiatric problems and cognitive level, to estimate the size of the CTG expansion, and to correlate the molecular findings with the neuropsychiatric problems. Fifty-seven children and adolescents (26 females; 31 males) with DM1 (CTG repeats > 40) were included in the study. The following instruments were used: Autism Diagnostic Interview-Revised (ADI-R), 5-15, Griffiths Mental Development Scales, and the Wechsler Scales. Based on age at onset and presenting symptoms, the children were divided into four DM1 groups; severe congenital (n = 19), mild congenital (n = 18), childhood (n = 18), and classical DM1 (n = 2). Forty-nine percent had an autism spectrum disorder (ASD) and autistic disorder was the most common diagnosis present in 35% of the subjects. Eighty-six percent of the individuals with DM1 had mental retardation (MR), most of them moderate or severe MR. ASD was significantly correlated with the DM1 form; the more severe the form of DM1, the higher the frequency of ASD. The frequency of ASD increased with increasing CTG repeat expansions. ASD and/or other neuropsychiatric disorders such as attention deficit hyperactivity disorder, and Tourette's disorder were found in 54% of the total DM1 group. In conclusion, awareness of ASD comorbidity in DM1 is essential. Further studies are warranted to elucidate the molecular etiology causing neurodevelopmental symptoms such as ASD and MR in DM1.
Output: How is myotonic dystrophy inherited?
The major constituent of senile plaques in Alzheimer's disease is a 42-aa peptide, referred to as beta-amyloid (Abeta). Abeta is generated from a family of differentially spliced, type-1 transmembrane domain (TM)-containing proteins, called APP, by endoproteolytic processing. The major, relatively ubiquitous pathway of APP metabolism in cell culture involves cleavage by alpha-secretase, which cleaves within the Abeta sequence, thus precluding Abeta formation and deposition. An alternate secretory pathway, enriched in neurons and brain, leads to cleavage of APP at the N terminus of the Abeta peptide by beta-secretase, thus generating a cell-associated beta-C-terminal fragment (beta-CTF). A pathogenic mutation at codons 670/671 in APP (APP "Swedish") leads to enhanced cleavage at the beta-secretase scissile bond and increased Abeta formation. An inhibitor of vacuolar ATPases, bafilomycin, selectively inhibits the action of beta-secretase in cell culture, suggesting a requirement for an acidic intracellular compartment for effective beta-secretase cleavage of APP. beta-CTF is cleaved in the TM domain by gamma-secretase(s), generating both Abeta 1-40 (90%) and Abeta 1-42 (10%). Pathogenic mutations in APP at codon 717 (APP "London") lead to an increased proportion of Abeta 1-42 being produced and secreted. Missense mutations in PS-1, localized to chromosome 14, are pathogenic in the majority of familial Alzheimer's pedigrees. These mutations also lead to increased production of Abeta 1-42 over Abeta 1-40. Knockout of PS-1 in transgenic animals leads to significant inhibition of production of both Abeta 1-40 and Abeta 1-42 in primary cultures, indicating that PS-1 expression is important for gamma-secretase cleavages. Peptide aldehyde inhibitors that block Abeta production by inhibiting gamma-secretase cleavage of beta-CTF have been discovered.
Output: Which disease the London mutation involved in?
Activating point mutations in the K-Ras oncogene are among the most common genetic alterations in pancreatic cancer, occurring early in the progression of the disease. However, the function of mutant K-Ras activity in tumor angiogenesis remains poorly understood. Using human pancreatic duct epithelial (HPDE) and K-Ras4B(G12V)-transformed HPDE (HPDE-KRas) cells, we show that activated K-Ras significantly enhanced the production of angiogenic factors including CXC chemokines and vascular endothelial growth factor (VEGF). Western blot analysis revealed that K-Ras activation promoted the phosphorylation of Raf/mitogen-activated protein kinase kinase-1/2 (MEK1/2) and expression of c-Jun. MEK1/2 inhibitors, U0126 and PD98059, significantly inhibited the secretion of both CXC chemokines and VEGF, whereas the c-Jun NH(2)-terminal kinase inhibitor SP600125 abrogated only CXC chemokine production. To further elucidate the biological functions of oncogenic K-Ras in promoting angiogenesis, we did in vitro invasion and tube formation assays using human umbilical vein endothelial cells (HUVEC). HUVEC cocultured with HPDE-KRas showed significantly enhanced invasiveness and tube formation as compared with either control (without coculture) or coculture with HPDE. Moreover, SB225002 (a CXCR2 inhibitor) and 2C3 (an anti-VEGF monoclonal antibody) either alone or in a cooperative manner significantly reduced the degree of both Ras-dependent HUVEC invasiveness and tube formation. Similar results were obtained using another pair of immortalized human pancreatic duct-derived cells, E6/E7/st and its oncogenic K-Ras variant, E6/E7/Ras/st. Taken together, our results suggest that angiogenesis is initiated by paracrine epithelial secretion of CXC chemokines and VEGF downstream of activated oncogenic K-Ras, and that this vascular maturation is in part dependent on MEK1/2 and c-Jun signaling.
Output: Which is the molecular mechanism underlying K-ras alterations in carcinomas?
The Germans initial attack involved 410,000 men; just over 1,400 tanks, tank destroyers, and assault guns; 2,600 artillery pieces; 1,600 anti-tank guns; and over 1,000 combat aircraft, as well as large numbers of other Armoured fighting vehicle. These were reinforced a couple of weeks later, bringing the offensives total strength to around 450,000 troops, and 1,500 tanks and assault guns. Between 63,222 and 98,000 of their men were Killed in action, Missing in action, wounded in action, or prisoner of war. For the Americans, out of a peak of 610,000 troops, 89,000 became casualties out of which some 19,000 were killed. The "Bulge" was the largest and bloodiest single battle fought by the United States in World War II and the second bloodiest List of battles with most United States military fatalities.
Output: Which country had more casualties, they Germans or the Americans?
Brazil is a federation that consists of twenty-six states and one federal district. The biggest majority of Brazil's population belongs to the Christian religion and almost all of them are Catholics. This is something Brazil inherited being Portugal's colony . Historically, the country was a colony claimed by people from Portugal and this made Portuguese the official language. The Portuguese reached Brazil in 1500 and until that moment it was inhabited by semi-nomadic people. The Portuguese changed Brazil into a country of slaves until 1800, when Maria I of Portugal came to live in Brazil. The Queen did not stay long in Brazil, but during the 20 years of royal presence a lot of changes occurred: commercial ports to United Kingdom were opened; Brazil stopped being isolated from other countries. So at the moment of getting the independence on the 7th of September, 1822, Brazil already had the potential to develop. The Brazilian Empire, Pedro I, abolished slavery in 1888 in the face of Princess Isabel. A lot of European people started coming to Brazil and the industry of the country started working. In the 19th and the 20th century as it has been said above foreign people immigrated to Brazil and basically 5 million European and Japanese people became the residents of Brazil. The beginning of the 20th century was especially marked by the immigration of a lot of Asian people: Japanese, Korean and Chinese immigrants. As a matter of fact Japanese people do not immigrate a lot, and the fact that the Brazilian-Japanese people are the largest Japanese minority in the world does astonish greatly. The majority of the cultural inherits of Brazil are actually Portuguese, due to the fact that Brazil was Portugal's colony for a very long time. The southern states mainly consist of European population and the north and the northeast consist of a mixed population including Africans, Amerindians and Europeans. Most of this population is Roman Catholic. No other country in the world has the same amount of Catholics. The modern tendency of Brazil is the growing number of people calling themselves Protestants. Around 7.4% of the population don't believe any god. Some Brazilians, especially in the northern states are mixed Africans who prefer following the traditional African religions. Only 1.8% of the population chose Buddhism, Islam or Judaism. Though Brazil always tried to maintain democracy, it was failed several times by the dictatorship of Getulo Vargas. This fact could not affect the political situation in the country.
Output: Who might block the development of Brazil?
An electric transformer is a device that uses electromagnetic induction to change the voltage of electric current. Electromagnetic induction is the process of generating current with a magnetic field. It occurs when a magnetic field and electric conductor, such as a coil of wire, move relative to one another. A transformer may either increase or decrease voltage. You can see the basic components of an electric transformer in the Figure 1.1. Click image to the left or use the URL below. URL: The transformer in the diagram consists of two wire coils wrapped around an iron core. Each coil is part of a different circuit. When alternating current passes through coil P, it magnetizes the iron core. Because the current is alternating, the magnetic field of the iron core keeps reversing. This is where electromagnetic induction comes in. The changing magnetic field induces alternating current in coil S of the other circuit. Notice that coil P and coil S in the Figure 1.1 have the same number of turns of wire. In this case, the voltages of the primary and secondary currents are the same. Usually, the two coils of a transformer have different numbers of turns. In that case, the voltages of the two currents are different. When coil S has more turns than coil P, the voltage in the secondary current is greater than the voltage in the primary current (see Figure 1.2). This type of transformer is called a step-up transformer. Thats because it steps up, or increases, the voltage. When coil S has fewer turns of wire than coil P, the voltage in the secondary current is less than the voltage in the primary current (see Figure 1.3). This type of transformer is called a step-down transformer because it steps down, or decreases, the voltage. Q: Both step-up and step-down transformers are used in the electrical grid that carries electricity from a power plant to your home. Where in the grid do you think step-down transformers might be used? A: One place that step-down transformers are used is on the electric poles that supply current to homes. They reduce the voltage of the electric current before it enters home circuits.
Output: an electric transformer contains
Ant & Dec are an English comedy TV presenting duo, consisting of Anthony McPartlin OBE and Declan Donnelly OBE , from Newcastle upon Tyne, England. Formed after their meeting as actors on CBBC's drama, Byker Grove, the duo have led successful careers as television presenters, with hosting credits including SMTV Live, CD:UK, Friends Like These, Pop Idol, Ant & Dec's Saturday Night Takeaway, I'm a Celebrity...Get Me Out of Here!, PokerFace, Push the Button, Britain's Got Talent, Red or Black?, and Text Santa. Due to a difference in height - Ant being the taller at 5ft 8in , and Dec being two inches shorter at 5ft 6in - the pair identify themselves in the media by adopting the use of the 180-degree rule, with the exception of some early publicity shots. In addition to presenting, the duo are accomplished actors - both had leading roles in the 2006 film Alien Autopsy - operate as television producers - they own their own production company, Mitre Television - have presented the annual Brit Awards in 2001, 2015 and 2016, and are former pop musicians who operated under the aliases of their characters from Byker Grove. In a 2004 poll for the BBC, Ant & Dec were named the eighteenth most influential people in British culture.
Output: On which show did Anthony and Declan meet?
During the 1920s, specifically In 1928, the components of the Dow were increased to 30 stocks near the economic height of that decade, which was nicknamed the Roaring Twenties. This period downplayed the influence of an early Depression of 192021 plus certain international conflicts such as the Polish-Soviet war, the Irish Civil War, the Turkish War of Independence and the initial phase of the Chinese Civil War. The Wall Street Crash of 1929 and the ensuing Great Depression over the next several years returned the average to its starting point, almost 90% below its peak. By July 8, 1932, following its intra-day low of 40.56, the Dow would end up closing the session at 41.22. The high of 381.17 on September 3, 1929, would not be surpassed until 1954, in inflation-adjusted numbers. However, the bottom of the 1929 Crash came just 2 months later on November 13, 1929, when intra-day it was at the 195.35 level, closing slightly higher at 198.69. For the decade, the Dow would end off with a healthy 131.7% gain, from 107.23 points at the beginning of 1920, to a level of 248.48 points at the end of 1929, just before the Crash of 1929.
Output: Which years of the Roaring Twenties were actually a depression?
Mandy Hering (born 11 March 1984) is a German handball player.
Output: To which sports is Mandy Hering related?
In nuclear fusion, two or more small nuclei combine to form a single, larger nucleus. You can see an example in the Figure 1.1. In this example, nuclei of two hydrogen isotopes (tritium and deuterium) fuse to form a helium nucleus. A neutron and a tremendous amount of energy are also released. Nuclear fusion of hydrogen to form helium occurs naturally in the sun and other stars. It takes place only at extremely high temperatures. Thats because a great deal of energy is needed to overcome the force of repulsion between the positively charged nuclei. The suns energy comes from fusion in its core, shown in the Figure 1.2. In the core, temperatures reach millions of degrees Kelvin. Click image to the left or use the URL below. URL: The Sun Q: Why doesnt nuclear fusion occur naturally on Earth? A: Nuclear fusion doesnt occur naturally on Earth because it requires temperatures far higher than Earth tempera- tures. Scientists are searching for ways to create controlled nuclear fusion reactions on Earth. Their goal is develop nuclear fusion power plants, where the energy from fusion of hydrogen nuclei can be converted to electricity. You can see how this might work in the Figure 1.3. In the thermonuclear reactor, radiation from fusion is used to heat water and produce steam. The steam can then be used to turn a turbine and generate electricity. The use of nuclear fusion for energy has several pros. Unlike nuclear fission, which involves dangerous radioactive elements, nuclear fusion involves just hydrogen and helium. These elements are harmless. Hydrogen is also very plentiful. There is a huge amount of hydrogen in ocean water. The hydrogen in just a gallon of water could produce as much energy by nuclear fusion as burning 1,140 liters (300 gallons) of gasoline! The hydrogen in the oceans would generate enough energy to supply all the worlds people for a very long time. Unfortunately, using energy from nuclear fusion is far from a reality. Scientists are a long way from developing the necessary technology. One problem is raising temperatures high enough for fusion to take place. Another problem is that matter this hot exists only in the plasma state. There are no known materials that can contain plasma, although a magnet might be able to do it. Thats because plasma consists of ions and responds to magnetism. Click image to the left or use the URL below. URL:
Output: nuclear fusion occurs inside
The Malaria Policy Advisory Committee to the World Health Organization met in Geneva, Switzerland from 13 to 15 March, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting.Meeting sessions included: a review of the efficacy of artemisinin-based combination therapy in Guyana and Suriname; the outcomes from a consultation on non-malaria febrile illness; the outcomes from the second meeting of the Evidence Review Group on malaria burden estimation; an update on the review of the WHO Guidelines for the Treatment of Malaria; an update regarding progress on the constitution of the vector control Technical Expert Group; updates on the RTS, S/AS01 vaccine and the malaria vaccine technology roadmap; financing and resource allocation for malaria control; malaria surveillance and the need for a surveillance, monitoring and evaluation Technical Expert Group; criteria and classification related to malaria elimination; the next meeting of the Evidence Review Group on Intermittent Preventive Treatment in pregnancy; an update on the soon-to-be launched Elimination Scenario Planning Tool; and an update on the process for the Global Technical Strategy for Malaria Control and Elimination (2016-2025).Policy statements, position statements, and guidelines that arise from the MPAC meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme.
Output: RTS S AS01 vaccine was developed to prevent which disease?
The acromelic dysplasia group includes three rare disorders: Weill-Marchesani syndrome (WMS), Geleophysic dysplasia (GD) and Acromicric dysplasia (AD) all characterized by short stature, short hands and stiff joints. The clinical overlap between the three disorders is striking. Indeed, in addition to the diagnostic criteria, they all share common features including delayed bone age, cone shaped epiphyses, thick skin and heart disease. In contrast, a microspherophakic lens seems to be a characteristic feature of WMS whereas hepatomegaly and a severe outcome are encountered only in the most severe forms of GD. Finally, WMS is transmitted either by an autosomal dominant or an autosomal recessive (AR) mode of inheritance, GD by an autosomal recessive mode of inheritance and AD by an autosomal dominant mode of inheritance. Using genetic approaches, we have identified the molecular basis of WMS and GD which both involved the same superfamily of proteins, the ADAMTS [A Disintegrin-like And Metalloproteinase domain (reprolysin type) with ThromboSpondin type 1 repeats (TSR)]. We have found ADAMTS10 mutations in the recessive form of WMS and Fibrillin 1 mutations in the dominant form of WMS. More recently, we have identified ADAMTSL2 mutations in GD. The function of ADAMTS1 0 and AD AMTSL 2 are unknown. But the findings of FBN1 and ADAMTS10 mutations in WMS suggest a direct link between the two proteins. Using a yeast double hybrid screen, we have identified LTBP1 (Latent TGFbeta Binding protein 1) as a partner of ADAMTSL2. The combination of these findings suggests that ADAMTS10 and ADAMTSL2 are both involved in the microfibrillar network.
Output: What is the mode of inheritance of Acromicric dysplasia?
The Commando Order (German: Kommandobefehl) was issued by Adolf Hitler on 18 October 1942 stating that all Allied commandos encountered by German forces in Europe and Africa should be killed immediately without trial, even in proper uniforms or if they attempted to surrender.
Output: What was the date of Commando Order?
Molecular abnormalities caused by the hybrid Bcr-Abl gene are causally associated with the development and progression of Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML). Imatinib mesylate (STI571), a specific Bcr-Abl tyrosine-kinase signal-transduction inhibitor, has shown encouraging activity in phase I and II studies of CML. Here, we describe the use of imatinib mesylate to treat 75 patients in blast-phase CML (median age, 53 years; 65 with nonlymphoid and 10 with lymphoid blasts), and compare the results with those of a historical control group treated with standard cytarabine-based therapy. Imatinib mesylate was given as oral doses at 300 to 1000 mg per day and was the first salvage therapy for 47 patients. The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic phase; and 1 had a complete response in extramedullary blastic disease). Response rates were not different between nonlymphoid and lymphoid groups. The cytogenetic response rate was 16% (12 patients: 5 complete, 3 partial [Ph(+) below 35%], and 4 minor [Ph(+), 34% to 90%]). The estimated median overall survival was 6.5 months; the estimated 1-year survival was 22%. Response to therapy (landmark analysis at 8 weeks) was associated with survival prolongation. Compared with standard cytarabine combinations, imatinib mesylate therapy was less toxic and produced a higher response rate (55% versus 29%, P =.001), longer median survival (7 versus 4 months, P =.04), and lower 4-week induction mortality (4% versus 15%, P =.07). Imatinib mesylate is currently being tested in combination with other drugs to improve the prognosis for blast-phase CML.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Using post-embedding immunogold electron microscopy, TAR DNA-binding protein of 43 kDa (TDP-43) was localized to neuronal cytoplasmic (NCI) and intranuclear (NII) inclusions, as well as unmyelinated neurites, in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U), amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), Pick's disease (PiD) and Lewy body disease (LBD). The TDP-43 immunoreactive structures were morphologically heterogeneous. The most common was characterized by bundles of 10-20 nm diameter straight filaments with electron dense granular material within NCI, NII and neurites. This type of pathology was found in FTLD-U, ALS and some cases of AD. Less often, inclusions in neuritic processes of FTLD-U and some cases of AD contained 10-17 nm diameter straight filaments without granular material. A final type of TDP-43 immunoreactivity was labeling of filaments and granular material associated with tau filaments in neurofibrillary tangles of AD and Pick bodies of PiD or alpha-synuclein filaments in Lewy bodies of LBD. The results suggest that TDP-43 is the primary component of the granulofilamentous inclusions in FTLD-U and ALS. Similar inclusions sometimes accompany filamentous aggregates composed of other abnormal proteins in AD, PiD and LBD.
Output: Which is the primary protein component of Lewy bodies?
Last year, over 206,000 students from the United States studied abroad. Does that number surprise you? These students already know the benefits of studying abroad. You may be wondering why you should study abroad. Here are some answers for you. * Timing The absolutely best time in your life to study abroad is when you are in college. If you miss this opportunity, it's almost impossible for you to do it later in life. * To gain cross-cultural experience Life overseas makes you see your everyday world in a whole new light. You don't even realize it, but our culture shapes the way we view the world and affects us every minute of the day. Differences in culture are more than just differences in language, food, clothing and art. * To improve your communication skills and your self-confidence People who study abroad tend to be willing to take risks, willing to put themselves in unusual situations, and able to solve problems. * To become more fluent in a language or to learn a new language The world market is becoming smaller, and many companies require a second language. Foreign languages are not only valuable in the job market but also valuable in the real world. * For the adventure Travel to other cities within your host country and around neighboring countries. As you get to know your new classmates, roommates, and host family, you will gain a unique view on the host culture. Discover the differences and, more importantly, the many similarities between your worlds. The friendships you make will last long after the program. * To learn more about yourself Find out who you really are. What are your limits? How do you overcome the difficulties you've never _ before? How independent are you? These questions are hard to answer until you are removed from your usual surroundings. After solving difficult problems on your own overseas, you'll find that almost nothing will confuse you at home. Students who study abroad commonly report that their study abroad experience actually changed their lives.
Output: What is the best time in your life to study abroad according to the passage?
Soyuz T-3 was launched on 27 November 1980, and carried the 15th expedition to the Salyut 6 space station.
Output: What was the date Soyuz T-3 was launched?
William I of Hauteville (before 1010 -- 1046), known as William Iron Arm, was a Norman adventurer who was the founder of the fortunes of the Hauteville family.
Output: What family lineage was William Iron Arm part of?
Spirit Warrior, known in Japan as Kujaku-Oh ( Kujaku O, lit. Peacock King), is a manga by Makoto Ogino.
Output: The country for Spirit Warrior was what?
Imatinib was the first BCR-ABL tyrosine kinase inhibitor to become clinically available. In this study, we retrospectively evaluated the long-term efficacy of low-dose imatinib (final maintenance dose <300mg per day) due to intolerance, in comparison to optimal-dose imatinib (300mg per day) in patients with Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase. The Kaplan-Meier estimates of the median time to complete cytogenetic response, major molecular response, and complete molecular response were longer for 31 patients receiving low-dose imatinib (360, 1360, and 1420days, respectively) than 74 patients receiving optimal-dose imatinib (170, 420, and 720days, respectively). However, the differences in response shrank over time and progression-free survival were comparable between the two groups. These findings suggest that long-term treatment with low-dose imatinib is an acceptable alternative for patients with intolerance to the optimal dose.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Adelaide of Rheinfelden (or Adelaide of Swabia) (German: Adelheid) (1060s -- May 1090), was the daughter of Rudolf of Rheinfelden; and wife of King Ladislaus I of Hungary.
Output: What is Adelaide of Rheinfelden's spouse's name?