niryuu/sni-each-converted huggingface dataset:
Protein kinases (PKs) and lipid kinases (LKs) are good choices for targets of signal transduction therapy as these enzymes are involved in signaling pathways, and are often related to the pathogenesis of lymphoid malignancies. The attractiveness of PKs and LKs as drug able targets is enhanced by the fact that they are enzymes whose biological activity can be turned off by drugs that block their catalytic site. In the last few years small molecular kinase inhibitors (KIs) have been synthesized and become available for preclinical studies and clinical trials. The first KI, introduced into clinical practice in 1998, was imatinib mesylate, which became the first choice drug in chronic myeloid leukemia. More recently, several KIs have been developed to target the proximal B-cell receptor (BCR) signaling pathway including spleen tyrosine kinase inhibitor (Fostamatinib) and Bruton's tyrosine kinase inhibitors (Ibrutinib, AVL-263). These agents are currently evaluated in early clinical trials in chronic lymphocytic leukemia (CLL) and other diseases. Cyclin-dependent kinase (Cdk) inhibitors, flavopiridol (alvocidib), BMS-387032 (SNS-032), sunitinib and sorafenib are currently under evaluation in clinical trials for relapsed/refractory CLL. Multi-tyrosine kinase inhibitors including vandetanib (ZD6474) bosutinib (SKI-606), TKI258 (CHIR-258), pazopanib (GW786034) and axitinib (AG013736) have been also developed for the treatment of lymphoid malignancies. Phosphatidylinositol 3-kinases (PI3K ) are a family of lipid kinases that mediate signals from cell surface receptors. CAL-101 (GS-1101) is an oral PI3K-specific inhibitor which has shown preclinical and clinical activity against CLL. This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity of PK and LK inhibitors in CLL.
Output: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?
Interleukin-6 (IL-6) induces tumor growth, invasion, metastasis, and angiogenesis. Siltuximab (CNTO 328) is a chimeric, murine-human monoclonal antibody that specifically binds human IL-6 with high affinity. C-reactive protein (CRP) can be a pharmacodynamic (PD) marker of IL-6 bioactivity. Reductions in CRP may correlate with clinical activity and IL-6 bioactivity. Starting-dose selection for this study was based on a previous siltuximab study in multiple myeloma patients. Pharmacokinetic (PK)/PD modeling explored the relationship between siltuximab PK and CRP suppression following i.v. siltuximab infusion in a three-part phase I/II study in 68 metastatic renal cell carcinoma patients. Modeling results were then used to simulate and determine which siltuximab dosage regimens would maintain CRP suppression below the lower limit of quantification (4 mg/L). Siltuximab was given at 1, 3, 6, or 12 mg/kg at weeks 1 and 4 and then every 2 weeks for 2 cycles in part 1; at 3 or 6 mg/kg every 3 weeks for 4 cycles in part 2; and at 6 mg/kg every 2 weeks for 6 cycles in part 3. A two-compartment PK model adequately described the serum siltuximab concentration-time data. An inhibitory indirect response PD model examined the relationship between siltuximab concentrations and CRP suppression. PD parameter estimates seemed reliable and physiologically relevant. Simulations showed that 6 mg/kg siltuximab every 2 weeks or 9 mg/kg every 3 weeks would reduce serum CRP to below 4 mg/L. Using a stepwise design, PK/PD modeling was used to select the dose levels in this study. Furthermore, PK/PD modeling results were used to help select doses to be used in future siltuximab clinical development.
Output: Which interleukin is blocked by Siltuximab?
Parameria (common name naranjo podrido) is a genus of flowering plants in the dogbane family, Apocynaceae, first described as a genus in 1876.
Output: Is Parameria a genus or species?
Progress M-10 was launched at 00:05:25 GMT on 17 October 1991, atop a Soyuz-U2 carrier rocket flying from Site 1/5 at the Baikonur Cosmodrome.
Output: What was the date Progress M-10 was launched?
Friction is the force that opposes motion between any surfaces that are in contact. There are four types of friction: static, sliding, rolling, and fluid friction. Static, sliding, and rolling friction occur between solid surfaces. Fluid friction occurs in liquids and gases. All four types of friction are described below. Static friction acts on objects when they are resting on a surface. For example, if you are hiking in the woods, there is static friction between your shoes and the trail each time you put down your foot (see Figure 1.1). Without this static friction, your feet would slip out from under you, making it difficult to walk. In fact, thats exactly what happens if you try to walk on ice. Thats because ice is very slippery and offers very little friction. Q: Can you think of other examples of static friction? A: One example is the friction that helps the people climb the rock wall in the opening picture above. Static friction keeps their hands and feet from slipping. Sliding friction is friction that acts on objects when they are sliding over a surface. Sliding friction is weaker than static friction. Thats why its easier to slide a piece of furniture over the floor after you start it moving than it is to get it moving in the first place. Sliding friction can be useful. For example, you use sliding friction when you write with a pencil. The pencil lead slides easily over the paper, but theres just enough friction between the pencil and paper to leave a mark. Q: How does sliding friction help you ride a bike? A: There is sliding friction between the brake pads and bike rims each time you use your bikes brakes. This friction slows the rolling wheels so you can stop. Rolling friction is friction that acts on objects when they are rolling over a surface. Rolling friction is much weaker than sliding friction or static friction. This explains why most forms of ground transportation use wheels, including bicycles, cars, 4-wheelers, roller skates, scooters, and skateboards. Ball bearings are another use of rolling friction. You can see what they look like in the Figure 1.2. They let parts of a wheel or other machine roll rather than slide over on another. The ball bearings in this wheel reduce friction between the inner and outer cylinders when they turn. Fluid friction is friction that acts on objects that are moving through a fluid. A fluid is a substance that can flow and take the shape of its container. Fluids include liquids and gases. If youve ever tried to push your open hand through the water in a tub or pool, then youve experienced fluid friction. You can feel the resistance of the water against your hand. Look at the skydiver in the Figure 1.3. Hes falling toward Earth with a parachute. Resistance of the air against the parachute slows his descent. The faster or larger a moving object is, the greater is the fluid friction resisting its motion. Thats why there is greater air resistance against the parachute than the skydivers body.
Output: when you put on the brakes of your bike, the wheels stop turning. then friction between the wheels and the road slows your bike to a stop. which type of friction is this?
Type I interferons play an outstanding role in innate and adaptive immunity by enhancing functions of dendritic cells, inducing differentiation of monocytes, promoting immunoglobulin class switching in B cells and stimulating effector functions of T cells. The increased production of IFN/ by plasmacytoid dendritic cells could be responsible for not only efficient antiviral defence, but it also may be a pathological factor in the development of various autoimmune disorders. The first evidence of a genetic link between type I interferons and autoimmune diseases was the observation that elevated IFN activity is frequently detected in the sera of patients with systemic lupus erythematosus, and that this trait shows high heritability and familial aggregation in their first-degree healthy relatives. To date, a number of genes involved in interferon signalling have been associated with various autoimmune diseases. Patients with systemic lupus erythematosus, Sjogren's syndrome, dermatomyositis, psoriasis, and a fraction of patients with rheumatoid arthritis display a specific expression pattern of interferon-dependent genes in their leukocytes, termed the interferon signature. Here, in an attempt to understand the role of type I interferons in the pathogenesis of autoimmunity, we review the recent advances in the genetics of autoimmune diseases focusing on the association of genes involved in type I interferon pathways.
Output: Which is the most common gene signature in Rheumatoid Arthritis patients?
Viroids, subviral pathogens of plants, are composed of a single-stranded circular RNA of 246-399 nucleotides. Within the 27 viroids sequenced, avocado sunblotch, peach latent mosaic and chrysanthemum chlorotic mottle viroids (ASBVd, PLMVd and CChMVd, respectively) can form hammerhead structures in both of their polarity strands. These ribozymes mediate self-cleavage of the oligomeric RNAs generated in the replication through a rolling circle mechanism, whose two other steps are catalyzed by an RNA polymerase and an RNA ligase. ASBVd, and presumably PLMVd and CChMVd, replicate and accumulate in the chloroplast, whereas typical viroids replicate and accumulate in the nucleus. PLMVd and CChMVd do not adopt a rod-like or quasi rod-like secondary structure as typical viroids do but have a highly branched conformation. A pathogenicity determinant has been mapped in a defined region of the CChMVd molecule.
Output: Which are the smallest known subviral pathogens of plants?
In the Atlantic, the West India Company concentrated on wresting from Portugal its grip on the sugar and slave trade, and on opportunistic attacks on the Spanish treasure fleets on their homeward bound voyage. Bahia on the north east coast of Brazil was captured in 1624 but only held for a year before it was recaptured by a joint Spanish-Portuguese expedition. In 1628, Piet Heyn captured the entire Spanish treasure fleet, and made off with a vast fortune in precious metals and goods that enabled the Company two years later to pay its shareholders a cash dividend of 70%, though the Company was to have relatively few other successes against the Spanish. In 1630, the Dutch occupied the Portuguese sugar-settlement of Pernambuco and over the next few years pushed inland, annexing the sugar plantations that surrounded it. In order to supply the plantations with the manpower they required, a successful expedition was launched in 1637 from Brazil to capture the Portuguese slaving post of Elmina, and in 1641 successfully captured the Portuguese settlements in Angola. In 1642, the Dutch captured the Portuguese possession of Axim in Africa. By 1650, the West India Company was firmly in control of both the sugar and slave trades, and had occupied the Caribbean islands of Sint Maarten, Curacao, Aruba and Bonaire in order to guarantee access to the islands' salt-pans.
Output: What were two things the West India Company desired?
Days of Magic, Nights of War (2004) is the second book in a series of five by author Clive Barker, called The Books of Abarat.
Output: The writer of Days of Magic, Nights of War is who?
Evening Workshops Optional evening workshops will be held at small restaurants or other meeting places near the conference hotel. Meals and other costs are not included but are also optional. Locations will be announced at the conference site. Workshops are very loosely organized and most represent discussions that have been held at Society for Economic Botany (SEB) meetings over a series of years. Workshop 1: Student Network Date: Wednesday evening, Feb. 5th Chairs: Hugo de Boer and Arika Virapongse Sponsor: Society for Economic Botany Description: Student members of the SEB hold a networking mixer each year in order to meet each other and to become familiar with a variety of educational programs and faculty advisors . Faculty members who are part of training programs are encouraged to join the mixer to meet and talk with students. Workshop 2: Botanical Film Making Date: Wednesday evening, Feb. 5th Chair: David Strauch Sponsor: University of Hawaii Description: Digital film making is a particularly useful tool of linking cultural information to recognizable plants. This workshop is aimed towards increasing the quality of material recorded by giving participants greater control over the medium. We will cover technical aspects (e.g. camera settings, audio), technical aspects (framing, lighting, focus), and some ways of presenting the material. Experienced filmmakers are encouraged to attend, and participants are welcome to bring their own camera equipment. Workshop 3: Collections for Botany-- Collections Development and Management Date: Friday evening, Feb. 7th Chair: Jan Salick Sponsor: Society for Economic Botany Description: SEB is a network of researchers who have been developing standards for the development of collections of artifacts, plant samples and related materials. Participants discuss successes, problems, and funding sources for solving management issues.
Output: You are a college student, interested in plants and good at taking TV pictures. Which of the Evening Workshops is most suitable for you?
Asymptomatic colonization with methicillin-resistant Staphylococcus aureus (MRSA) has been described as a risk factor for subsequent MRSA infection. MRSA is an important nosocomial pathogen but has currently been reported in patients without typical risk factors for nosocomial acquisition. This study was designed to evaluate the impact of asymptomatic nares MRSA colonization on the development of subsequent MRSA infection. The incidence of MRSA infection was examined in patients with and patients without MRSA or methicillin-susceptible S. aureus (MSSA) colonization at admission to the hospital and in those who developed colonization during hospitalization. Patients admitted to 5 representative hospital units were prospectively evaluated. Nares samples were obtained for culture at admission and during hospitalization. Laboratory culture results were monitored to identify all MRSA infections that occurred during the study period and 1 year thereafter. Of the 758 patients who had cultures of nares samples performed at admission, 3.4% were colonized with MRSA, and 21% were colonized with MSSA. A total of 19% of patients with MRSA colonization at admission and 25% who acquired MRSA colonization during hospitalization developed infection with MRSA, compared with 1.5% and 2.0% of patients colonized with MSSA (P<.01) and uncolonized (P<.01), respectively, at admission. MRSA colonization at admission increased the risk of subsequent MRSA infection, compared with MSSA colonization (relative risk [RR], 13; 95% confidence interval [CI], 2.7-64) or no staphylococcal colonization (RR, 9.5; 95% CI, 3.6-25) at admission. Acquisition of MRSA colonization also increased the risk for subsequent MRSA infection, compared with no acquisition (RR, 12; 95% CI, 4.0-38). MRSA colonization of nares, either present at admission to the hospital or acquired during hospitalization, increases the risk for MRSA infection. Identifying MRSA colonization at admission could target a high-risk population that may benefit from interventions to decrease the risk for subsequent MRSA infection.
Output: What is MRSA?
McGill Comedy Club Important meetings today. Discussion on putting on Blazing Saddles. Union room 302, 3-4pm. New members (both actors and non-actors, living and dead) are welcome. History Students' Association Prof. Michael Cross of Dalhouseie University will be speaking on "Unskilled Labor on Rivers and Canals in Upper Canada, 1820-1850: The beginning of Class Struggle" at 10am. in Peacock 230. Design Mirror Sale All types and sizes of design mirrors priced to please. Sale today in Union room 108. McGill Teaching Assistants' Association A general meeting, for all the Tas will be held at 4pm. in peacock 116. Women's Union Important general meeting at 6pm. Union room 423. Speaker on "Importance of Deciding Basic Goals of the Women's Union." Everyone ----old, new and those interviewed, please attend. Film Society Last meeting of the term for all members. All managers are required to be present at 6pm. sharp, Union room 434. Canadian University Students Overseas CUSO presents "Guess Who's Coming to Breakfast" at 7pm. newman Centre, 3848 Peel. Find out about CUSO here and overseas. Everyone welcome.
Output: If you are interested in arts, where can you go for a visit?
Konstantinos Raktivan (Greek: ; 1865 -- 21 May 1935) was a Greek jurist and politician, who served as cabinet minister, as the de facto first Governor-General of Macedonia, president of the Athens Bar Association and of the Council of State, Speaker of the Hellenic Parliament and member and president of the Academy of Athens.
Output: Who led Konstantinos Raktivan?
Ring finger protein 5 pseudogene 1, also known as RNF5P1, is a human gene.
Output: In what living being can RNF5P1 be found?
Human population growth over the past 10,000 years has been tremendous (Figure 1.1). The entire human popula- tion was estimated to be 5 million in 8000 B.C. 300 million in A.D. 1 1 billion in 1802 3 billion in 1961 7 billion in 2011 As the human population continues to grow, different factors limit population in different parts of the world. What might be a limiting factor for human population in a particular location? Space, clean air, clean water, and food to feed everyone are limiting in some locations. Not only has the population increased, but the rate of population growth has increased (Figure 1.2). The population was estimated to reach 7 billion in 2012, but it did so in 2011, just 12 years after reaching 6 billion. Human population from 10,000 BC through 2000 AD, showing the exponential increase in human population that has occurred in the last few centuries. The amount of time between the addition of each one billion people to the planets population, including speculation about the future. Although population continues to grow rapidly, the rate that the growth rate is increasing has declined. Still, a recent estimate by the United Nations estimates that 10.1 billion people will be sharing this planet by the end of the century. The total added will be about 3 billion people, which is more than were even in existence as recently as 1960.
Output: human population reached its first billion in which year?
SET domain genes have been identified in numbers of bacterial genomes based on similarity to SET domains of eukaryotic histone methyltransferases. Herein, a Chlamydophila pneumoniae SET domain gene was clarified to be coincidently expressed with hctA and hctB genes encoding chlamydial histone H1-like proteins, Hc1 and Hc2, respectively. The SET domain protein (cpnSET) is localized in chlamydial cells and interacts with Hc1 and Hc2 through the C-terminal SET domain. As expected from conservation of catalytic sites in cpnSET, it functions as a protein methyltransferase to murine histone H3 and Hc1. However, little is known about protein methylation in the molecular pathogenesis of chlamydial infection. cpnSET may play an important role in chlamydial cell maturation due to modification of chlamydial histone H1-like proteins.
Output: What is the characteristic domain of histone methyltransferases?
C/2013 R1 (Lovejoy) is a long-period comet discovered on 7 September 2013 by Terry Lovejoy using a 0.2-meter (8 in) Schmidt--
Output: When was C/2013 R1 discovered?
Coming off their win over the Browns, the Bears stayed at home for a Week 9 duel with the Arizona Cardinals. Chicago would trail early in the first quarter as Cardinals quarterback Kurt Warner hooked up with wide receiver Larry Fitzgerald on an 11-yard touchdown pass. The Bears would answer as quarterback Jay Cutler competed a 33-yard touchdown pass to tight end Greg Olsen, but Arizona came right back as Warner hooked up with tight end Ben Patrick on a 6-yard touchdown pass. Chicago would find themselves in a huge deficit in the second quarter as Warner completed a 17-yard touchdown pass to Fitzpatrick and a 15-yard touchdown pass to tight end Anthony Becht, followed by kicker Neil Rackers nailing a 43-yard field goal. The Cardinals would add onto their lead as Rackers booted a 30-yard field goal in the third quarter. The Bears tried to rally in the fourth quarter as Cutler connected with Olsen on a 3-yard and a 20-yard touchdown pass, but Arizona pulled away with Warner completing a 4-yard touchdown pass to wide receiver Steve Breaston.
Output: Which player caught the most touchdown passes?
A volcanic eruption in Iceland has sent ash across northern Europe. Airlines have stopped or changed the flights across the Atlantic Ocean, leaving hundreds of passengers stuck in airports. Grimsvotn is one of the largest and most active volcanoes in Europe. What makes Grimsvotn different is that it lies under a huge glacier of ice up to 12 metres thick. The hot volcano heats up the ice above it, which then forms a layer of water between glacier and the volcano, keeping it stable. As the water flows out from under the glacier, the pressure lifts. The lava from the volcano then comes up to the surface. This is exactly what is happening today. Now airlines have to make changes to their flights so as not to fly through the clouds of volcanic ash. According to KLM, one of Europe's biggest airlines, airplanes cannot go under the cloud or over it. Going through the cloud can result in ash getting stuck in the airplane's engines, causing damage to the plane. The eruption has also caused problems for animals in Iceland. The volcano left ash and sharp, glass-like rocks all over the countryside. Farmers are keeping their animals inside to stop them eating ash-covered grass or the sharp objects.
Output: how many passengers were forced to stay in the airport?
Woldemichael Ghebremariam is the second Minister of Land, Water, & Environment of Eritrea.
Output: What is Woldemichael Ghebremariam's country of citizenship?
Infection with Epstein-Barr virus (EBV) is almost ubiquitous in humans and generally occurs at two ages: infantile, which is usually asymptomatic and associated with poorer socioeconomic conditions, and adolescent, which causes infectious mononucleosis (IM) in ~25% cases. The determinants of whether the infection causes IM remain uncertain. We aimed to evaluate seasonality and temporal trends in IM. Data from all Monospot tests, used as a marker for IM, were collected from the Grampian population over 16 years. Positive Monospot test results peaked at 17 years in females and 19 in males. Females had 16% more diagnoses, although 55% more tests. IM was ~38% more common in winter than summer. The annual rate of positive tests decreased progressively over the study period, from 174/100 000 (95% CI 171-178) in 1997 to 67/100 000 (95% CI 65-69) in 2012. IM appears to be decreasing in incidence, which may be caused by changing environmental influences on immune systems. One such factor may be exposure to sunlight.Words 168. The Medical Research Council and NHS Grampian-MS endowments.
Output: Which virus can be diagnosed with the monospot test?
Following their victory over the Patriots, the Steelers remained at home the next week for their second match-up of the season against division rivals the Baltimore Ravens. The Ravens scored first with an 18-yard field goal by kicker Billy Cundiff, the only points scored in the first quarter by either team. Steelers kicker Shaun Suisham answered with a 36-yard field goal early in the second quarter, and a 30-yard field goal near the end, but both of these were quickly matched by Baltimore's Cundiff with a 43-yard and 51-yard field goal, respectively, giving Baltimore a 9-6 lead at halftime. The Ravens then increased their lead in the third quarter when Ray Rice scored the first touchdown of the game on a 4-yard run. The Steelers rallied hard in the fourth quarter, with running back Rashard Mendenhall making a 1-yard run to score a touchdown, and then taking the lead for the first time in the game when quarterback Ben Roethlisberger made a successful 25-yard pass to wide receiver Mike Wallace in the endzone for a second touchdown. On their final drive of the game, the Steelers were ready to potentially increase their lead with a 47-yard field goal kick by Shaun Suisham, but a 5-yard delay of game penalty put them out of field goal range and they were instead forced to punt the ball to the Ravens. The Ravens then began a 92-yard drive, culminating in a 26-yard touchdown pass by quarterback Joe Flacco to wide receiver Torrey Smith in the endzone with just 8 seconds remaining, giving them the game.
Output: Who kicked the two longest field goals of the game?
Focusing on three Anglo-American outbreaks of industrial anthrax, this essay engages the question of how local circumstances influenced the transmission of scientific knowledge in the late nineteenth century. Walpole (Massachusetts), Glasgow, and Bradford (Yorkshire) served as important nodes of transnational investigation into anthrax. Knowledge about the morphology and behavior of Bacillus anthracis changed little while in transit between these nodes, even during complex debates about the nature of bacterial morphology, disease causation, and spontaneous generation. Working independently of their more famous counterparts (Robert Koch and Louis Pasteur), Anglo-American anthrax investigators used visual representations of anthrax bacilli to persuade their peers that a specific, identifiable cause produced all forms of anthrax-malignant pustule (cutaneous anthrax), intestinal anthrax, and woolsorter's disease (pneumonic anthrax). By the late 1870s, this point of view also supported what we would today call an ecological notion of the disease's origins in the interactions of people, animals, and microorganisms in the context of global commerce.
Output: What organism causes woolsorter's disease
Asia has many wild places. The following national parks are among the most famous in Asia. People come to visit them from near and far in order to appreciate the unique qualities of the land and everything on it. Have you ever visited any of these Asian national parks? Jiuzhai Valley National Park, China The extraordinarily beautiful park is famous for its fascinating blue-green lakes, waterfalls and its unique wildlife. Located in the Minshan Mountain, Sichuan Province, it is a breathtaking park because of its scenery and it is also home to nine Tibetan villages, over 220 bird species as well as a number of endangered animals and plants, such as giant pandas, Sichuan golden monkeys and numerous _ . This park was also declared a UNESCO World Heritage Site in 1992. Khao Sok National Park, Thailand This extraordinary park is several miles away from Phuket , yet its remoteness prevents it from being visited. Even so, it is well worth a visit as scientists have noted that is rainforest stretches are not only longer than those of the Amazon, but also more divers . Animals like tigers, Asian elephants, and macaaues make their home here. Everyone who visits the park, however, seems to want to have a look at the amazing Rafflesia, one of the strangest flowering plants on earth; it smells like smelly meat when it blooms. Nikko National Park, Japan It is lovely to visit this park all the year round with its waterfalls and picturesque Lake Chuzenji. And it is especially worth visiting in autumn when the leaves change from green to deep red and orange. Set with UNESCO protected shrines and temples, the park is a unique mixture of natural and man-made attractions. With various routes perfect for adventurous hikers, a visit to the Nikko National Park is not to be missed. If you want to know more information about Asian famous national parks, you can log in [Link] If you want to enjoy all the above, welcome to call 050-24689120, and we can give a reasonable price.
Output: If you're an adventurous hiker, which park would you probably choose to visit?
Chronic myeloid leukemia (CML) is caused by Bcr-Abl, a constitutively active tyrosine kinase that is the result of a reciprocal translocation between chromosomes 9 and 22 and cytogenetically evident as the Philadelphia chromosome. Imatinib (Glivec, Gleevec), a specific small molecule inhibitor of Bcr-Abl, has become the standard drug therapy for CML, and has dramatically diminished the use of allogeneic stem cell transplantation. Despite unprecedented rates of complete cytogenetic response, residual disease remains detectable in the majority of patients, suggesting that imatinib fails to eradicate leukemic stem cells. In this publication, the current perspectives for CML patients treated with imatinib are reviewed, focusing on the results of both standard and high-dose therapy. Monitoring of time-dependent prognostic factors is reviewed. The reasons imatinib may not be able to eradicate the disease are discussed, and potential strategies to achieve disease elimination are presented. Lastly, resistance to imatinib and the potential of second-generation Abl kinase inhibitors in the setting of clinical resistance are considered.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Amber Leighton (Madonna) is 40: beautiful, rich, spoiled, foul-mouthed, and arrogant beyond measure. Nothing makes this woman happy, including her wealthy but passive husband, Tony (Bruce Greenwood), a pharmaceutical kingpin. When Tony takes her on a private cruise from Greece to Italy with two other couples, Amber is unimpressed by this impromptu no-frills vacation and takes out her anger on the ship's first mate, Giuseppe Esposito (Adriano Giannini). When a storm leaves the two shipwrecked on a deserted island, however, the tables suddenly turn, with Giuseppe gaining the upper hand, followed by the two falling in love.
Output: Who does the woman become dependent upon for survival?
Mutations of the epidermal growth factor receptor (EGFR) gene have been reported in non-small-cell lung cancer (NSCLC), especially in patients with adenocarcinoma and never smokers. Some common somatic mutations in EGFR, including deletion mutations in exon 19 and leucine-to-arginine substitution at amino acid position 858 (L858R) in exon 21, have been examined for their ability to predict sensitivity to gefitinib or erlotinib, which are selective EGFR tyrosine kinase inhibitors (EGFR-TKIs). On the other hand, reports have shown that the threonine-to-methionine substitution at amino acid position 790 (T790M) in exon 20 is related to gefitinib resistance. Some studies have indicated that high copy numbers of the EGFR gene may be a more effective molecular predictor to responsiveness and prolonged survival in patients treated with EGFR-TKIs. Here, we describe two NSCLC patients with the L858R mutation who did not respond to gefitinib. Case 1 harbored both the T790M and L858R mutations, and fluorescence in situ hybridization showed EGFR gene amplification. Case 2 harbored both the L858R and aspartic acid-to-tyrosine substitution at amino acid position 761 in exon 19 of EGFR mutations and had a high polysomy status for EGFR. In these two cases, tumors showed resistance to gefitinib treatment despite the presence of EGFR L858R mutation and increased copy number. Our findings encourage further molecular analysis to elucidate the relationship between the EGFR status, including mutations and amplifications, and the responsiveness of NSCLC to gefitinib.
Output: Mutations in which gene determine response to both erlotinib and gefitinib?
The fighting against youth smoking since I took office I've done everything in my power to protect our children from harm. We've worked to make their streets and their schools safer, and to give them something positive to do after school before their parents get home. We've worked to teach our children that drugs are dangerous, illegal and wrong. Today, I want to talk to you about the historic opportunity we now have to protect our nation's children form an even more deadly threat: smoking. Smoking kills more people every day than AIDS, alcohol, car accidents, murders, suicides, drugs and fires combined. Nearly 90 percent of those smokers lit their first cigarette before they turned 18. Consider this: 3,000 children start to smoke every day illegally, and 1,000 of them will die sooner because of it. This is a national tragedy that every American should be honor-bound to help prevent. For more than five years we've worked to stop our children from smoking before they start, launching a nationwide campaign to educate them about the dangers of smoking, to reduce their access to tobacco products, and to severely restrict tobacco companies from advertising to young people. If we do these, we'll cut teen smoking by almost half over the next five years. That means if we act now, we have it in our power to stop 3 million children from smoking and to save a million lives as a result.
Output: How many children will be stopped from smoking if we act now?
In 1804, all of the Louisiana Purchase south of the 33rd parallel became the Orleans Territory, and the remainder became the District of Louisiana. The Organic Act of 1804, passed on March 26 for October 1 implementation, also created the United States District Court for the District of Orleansthe only time Congress has ever provided a territory with a United States district court equal in its authority and jurisdiction to those of the states. Congress also established the Superior Court for the Territory of Orleans whose three judges were the top territorial court. On April 10, 1805, the Territorial Legislature organized 12 counties : Orleans County, LaFourche County, German Coast, Acadia County, Iberville County, Attakapas County, Pointe Coupee County, Opelousas County, Rapides County, Concordia County, Natchitoches County, and Ouachita County. The Florida Parishes on the east side of the Mississippi River were not included in Orleans Territory at this time, as they were in the Spanish territory of West Florida until they were formally annexed on April 14, 1812. The western boundary with Spanish Texas was not fully defined until the Adams-Onis Treaty in 1819. A strip of land known as the Sabine Free State just east of the Sabine River served as a neutral ground buffer area from about 1807 until 1819. The Orleans Territory was the site of the largest slave revolt in American history, the 1811 German Coast Uprising.
Output: What was not included?
Sophie Marie of Hesse-Darmstadt (7 May 1661, Darmstadt -- 22 August 1712, Gotha) was a member of the House of Hesse and by marriage Duchess of Saxe-Eisenberg.
Output: What noble family was Sophie Marie of Hesse-Darmstadt part of?
The clinical efficacy of different doses of the specific benzodiazepine antagonist flumazenil was studied in a total of 72 patients with benzodiazepine or ethanol overdose. In a randomized double-blind study, 18 patients (group 1) and eight patients (group 2) with suspected benzodiazepine overdose received 5 mg (group 1) or 1 mg (group 2) flumazenil or placebo, respectively. The stage of coma, heart rate, blood pressure and respiratory rate were monitored within the following 15 min. If no change in the stage of coma was observed, 5 mg (group 1) or 1 mg (group 2) flumazenil were given, and the stage of coma, heart rate and blood pressure were again monitored. In a similar way, the effect of 5 and 1 mg flumazenil was investigated in 13 patients (group 3) and four patients (group 4) with ethanol intoxication. In an open trial, the clinical efficacy of flumazenil for the diagnosis of benzodiazepine or ethanol overdose was studied in 29 patients (group 5). In all patients, a toxicological screening confirmed benzodiazepine or ethanol overdose. None of the patients receiving placebo showed effects on stage of coma, heart rate, blood pressure or respiratory rate. Patients with benzodiazepine overdose who received 5 mg flumazenil regained consciousness about 1-2 min after the end of injection. The effect of 1 mg flumazenil (group 2) on benzodiazepine-induced coma was less pronounced. In patients with ethanol overdose (group 3), ethanol-induced coma was reversed after 5 mg flumazenil more slowly than in patients of group 1. No effect of flumazenil on ethanol-induced coma was observed in group 4. In group 5, flumazenil proved to be useful for diagnosing benzodiazepine or ethanol intoxication. In one patient with coma due to carbamazepine overdose, flumazenil was also found to be effective. Additionally, a possible analytical interference of flumazenil and its metabolites with the identification of other benzodiazepines by a toxicological screening procedure was studied. Even after an oral dose of 200 mg flumazenil, no interference with immunological benzodiazepine assays (EMIT, TDX, and RIA) was found. A metabolite and an artifact of flumazenil could be identified in urine by gas chromatography/mass spectrometry.
Output: Which drug should be used as an antidote in benzodiazepine overdose?
Cathepsin L2, also known as cathepsin V and encoded by the CTSL2 gene, is a human gene.
Output: Which species has the Cathepsin L2 gene?
Comgas is a Brazilian gas distributor focused on Sao Paulo state.
Output: What is the city where Comgás is from?
Monosomy for the X chromosome is the most frequent cause of Turner's syndrome, a common clinical syndrome associated with particular physical and neurobehavioral features. The results from comprehensive assessment of prepubertal monozygotic female twins discordant for X monosomy are presented. Zygosity was established with DNA Fingerprinting and no evidence of chromosomal mosaicism was seen in either child. Physical features in the affected twin were relatively mild with respect to the full spectrum of physical malformations and disabilities associated with Turner's syndrome. The neurobehavioral phenotypes of the twins were compared. Although both sisters scored in the superior range of intelligence, the affected twin's Performance IQ was 18 points less than her sister, whereas Verbal IQ showed only a 3-point difference between the sisters. Other relative differences were noted within the executive, visuospatial, and visuomotor domains of function. Behavioral evaluation indicated greater problems with attention, hyperactivity, and anxiety in the affected twin. Quantitative analysis of brain anatomy revealed evidence of both general and regional effects of X monosomy on neurodevelopment. Cerebrospinal fluid volume was increased by 25% in the affected twin compared with her sister with a corresponding decrease in gray matter volume. The right frontal, right parietal-occipital, and left parietal-perisylvian regions showed the greatest discrepancy between the sisters with respect to increased cerebrospinal fluid and decreased gray matter volumes in twin with X monosomy. Differences in the posterior fossa were also noted with a 50% relative increase in the volumes of the fourth ventricle and cisterna magna and a 10 to 15% relative reduction in size of the cerebellar vermis, pons, and medulla in the affected twin. The association between the neurobehavioral and neuroanatomical findings in the affected twin is discussed. The unique nature of the naturally occurring genetic phenomenon seen in this twin pair provides an opportunity to more fully elucidate the neurobehavioral phenotype associated with X monosomy and Turner's syndrome.
Output: What chromosome is affected in Turner's syndrome?
The architect of Les Invalides was Liberal Bruant.
Output: Who was responsible for the design of Les Invalides?
The 15th Cabinet of Puerto Rico is the cabinet that served under Governor of Puerto Rico, Luis Fortuno from January 2, 2009 to January 2, 2013.
Output: Who was in charge of 15th Cabinet of Puerto Rico?
A common challenge in pathogen discovery by deep sequencing approaches is to recognize viral or subviral pathogens in samples of diseased tissue that share no significant homology with a known pathogen. Here we report a homology-independent approach for discovering viroids, a distinct class of free circular RNA subviral pathogens that encode no protein and are known to infect plants only. Our approach involves analyzing the sequences of the total small RNAs of the infected plants obtained by deep sequencing with a unique computational algorithm, progressive filtering of overlapping small RNAs (PFOR). Viroid infection triggers production of viroid-derived overlapping siRNAs that cover the entire genome with high densities. PFOR retains viroid-specific siRNAs for genome assembly by progressively eliminating nonoverlapping small RNAs and those that overlap but cannot be assembled into a direct repeat RNA, which is synthesized from circular or multimeric repeated-sequence templates during viroid replication. We show that viroids from the two known families are readily identified and their full-length sequences assembled by PFOR from small RNAs sequenced from infected plants. PFOR analysis of a grapevine library further identified a viroid-like circular RNA 375 nt long that shared no significant sequence homology with known molecules and encoded active hammerhead ribozymes in RNAs of both plus and minus polarities, which presumably self-cleave to release monomer from multimeric replicative intermediates. A potential application of the homology-independent approach for viroid discovery in plant and animal species where RNA replication triggers the biogenesis of siRNAs is discussed.
Output: Which are the smallest known subviral pathogens of plants?
With the new school year quickly coming near (or perhaps, for your early-starters, already under way), it's time to get ready for a successful term . And while you may be cleaning your wardrobe , it's equally important to freshen up your study skills, too. Have you ever noticed that your study habits are different from those of your friends? Or how you seem to learn faster in certain classes? Some people are quick to blame the teacher or subject for their difficulties, but that isn't always the cause . One thing that many people seem to ignore is their learning type. Now, you may be wondering what a learning type is and how to find yours. There are three different learning types: Visual, Auditory, and Kinesthetic. You can be a _ of learning types, but most people have one main type. 1. Visual learners learn best by seeing. If you seem to easily get information from pictures, graphs, and videos, you are likely a visual learner. 2. Auditory learners learn best by hearing. If you seem to remember things by hearing them, whether listening to a lecture or repeating information out loud, then you are likely an auditory learner. 3. Kinesthetic learners learn best by doing. If you seem to learn best by working with your hands or testing out what you are shown, you are likely a kinesthetic learner. So now that you know your personal learning style, the trick is to find out how to use your new-found knowledge to help you in your classes.
Output: Stephen loves science and usually does experiments with his classmates in the lab to test what he has learned. So what type of learner is he?
After the fall of Pegu in December 1599, Lower Burma was in utter chaos, and politically fragmented among Toungoo, Prome, Arakanese/Portuguese Syriam and Siamese Martaban. In Upper Burma, however, Nyaungyan, viceroy of Ava, had been quietly consolidating his holdings since 1597. Though nominally loyal to Nanda, Nyaungyan provided no support to his overlord. In October 1599, just as Toungoo and Arakanese were laying siege on Pegu, Nyaungyan sent a force to reclaim Mohnyin, Mogaung, and Bhamo. After Pegu fell, Nyaungyan declared himself king on 25 February 1600. Nyaungyan then systematically reacquired nearer Shan states. He captured Nyaungshwe in February 1601, and the large strategic Shan state of Mone in July 1603, bringing his realm to the border of Siamese Lan Na. In response, Naresuan of Siam marched in early 1605 to attack Mone but died at the border in April after which Siam ceased to be a military concern to Burma. In early 1606, his 7,000-strong forces took Theinni, Thibaw and Momeik but the king died during the campaign on 3 March 1606.
Output: Which place did Nyaungyan capture later, Nyaungshwe or the Shan state of Mone?
Friedrich Karl Max Vierhapper (7 March 1876 in Weidenau -- 11 July 1932) was an Austrian plant collector, botanist and professor of botany at the University of Vienna.
Output: What is the name university that educated Friedrich Karl Max Vierhapper?
The lithosphere is composed of both the crust and the portion of the upper mantle that behaves as a brittle, rigid solid. The lithosphere is the outermost mechanical layer, which behaves as a brittle, rigid solid. The lithosphere is about 100 kilometers thick. How are crust and lithosphere different from each other? The definition of the lithosphere is based on how Earth materials behave, so it includes the crust and the uppermost mantle, which are both brittle. Since it is rigid and brittle, when stresses act on the lithosphere, it breaks. This is what we experience as an earthquake. Although we sometimes refer to Earths plates as being plates of crust, the plates are actually made of lithosphere. Much more about Earths plates follows in the chapter "Plate Tectonics." The asthenosphere is solid upper mantle material that is so hot that it behaves plastically and can flow. The lithosphere rides on the asthenosphere.
Output: this layer is made up of both the crust and uppermost mantle.
Restriction endonucleases play a very important role in genetic engineering and DNA mapping. Among hundreds of restriction endonucleases, the Eco R1 enzyme is the most useful and widely investigated enzyme. After sonication and ultracentrifugation, crude extracts of E. coli RY 13 were purified by employing the polyethyleneimine precipitate, ammonium sulfate precipitate and heparin Sepharose-4B affinity column chromatography. The Eco R1 enzyme were purified at about 42 folds and the specific activity was about 100,000 U/mg of protein. The whole purification procedure was finished within two days. The recovery was about 42%. The enzyme was sufficiently concentrated for direct specific DNA hydrolysis.
Output: Which bacteria was EcoRI, restriction endonuclease isolated from?
Alison Gopnik (born June 16, 1955) is an American professor of psychology and affiliate professor of philosophy at the University of California, Berkeley.
Output: What is Alison Gopnik's place of employment?
Founded in Paris by Marco Tinelli in 1998 under the name Grey Interactive, over the past 15 years the digital agency has become an integrated communications group composed of 20 agencies around Europe and in 8 different countries (France, Spain, Portugal, Italy, United Kingdom, Germany, U.S. and China) FullSIX Group has 10 agency networks:
Output: In what city is FullSIX based?
The Wittig reaction was discovered in 1954 by Georg Wittig, for which he was awarded the Nobel Prize in Chemistry in 1979.
Output: Who is the Wittig reaction named after?
Leptoxis ampla is a vulnerable species according to the IUCN Red list.
Output: What is an ecological status of Leptoxis ampla?
The 4th of August Party (Greek: 4 , Komma 4is Avgoustou, 4) was a radical Greek nationalist political party, founded in July 1965 by a group of young nationalists and led by Konstantinos Plevris.
Output: Who led 4th of August Party?