niryuu/sni-each-converted huggingface dataset:
Stephen L. Golding (born 1944) is an emeritus professor of psychology at the University of Utah and a forensic psychologist who has written a large amount of articles on the process of determining whether people are competent to stand trial.
Output: What is Stephen L. Golding's place of employment?
Here, we report the biochemical and genetic basis of the Vel blood group antigen, which has been a vexing mystery for decades, especially as anti-Vel regularly causes severe haemolytic transfusion reactions. The protein carrying the Vel blood group antigen was biochemically purified from red blood cell membranes. Mass spectrometry-based de novo peptide sequencing identified this protein to be small integral membrane protein 1 (SMIM1), a previously uncharacterized single-pass membrane protein. Expression of SMIM1 cDNA in Vel- cultured cells generated anti-Vel cell surface reactivity, confirming that SMIM1 encoded the Vel blood group antigen. A cohort of 70 Vel- individuals was found to be uniformly homozygous for a 17 nucleotide deletion in the coding sequence of SMIM1. The genetic homogeneity of the Vel- blood type, likely having a common origin, facilitated the development of two highly specific DNA-based tests for rapid Vel genotyping, which can be easily integrated into blood group genotyping platforms. These results answer a 60-year-old riddle and provide tools of immediate assistance to all clinicians involved in the care of Vel- patients.
Output: Which gene-defect causes the Vel-blood type?
I travel a lot, and I find out different "styles" of directions every time I ask "How can I get to the post office?" Foreign tourists are often confused in Japan because most streets there don't have names; in Japan, people use landmarks in their directions instead of street names. For example, the Japanese will say to travelers,"Go straight down to the corner. Turn left at the big hotel and go past a fruit market. The post office is across from the bus stop. " In the countryside of the American Midwest, there are not usually many landmarks. There are no mountains, so the land is very flat; in many places there are no towns or buildings within miles. Instead of landmarks, people will tell you directions and distances. In Kansas or Iowa, for example, people will say," Go north two miles. Turn east, and then go another mile. " People in Los Angeles, California, have no idea of distance on the map; they measure distance in time, not miles. "How far away is the post office?" you ask. "Oh," they answer,"it's about five minutes from here. " You say," Yes, but how many miles away is it?"They don't know. It's true that a person doesn't know the answer to your question sometimes. What happens in such a situation? A New Yorker might say," Sorry, I have no idea. "But in Yucatan, Mexico, no one answers "I don't know." People in Yucatan believe that "I don't know. "is impolite. They usually give an answer, often a wrong one. A tourist can get very, very lost in Yucatan !
Output: What is the place where people measure distance in time?
Diary of a Wimpy Kid: The Third WheelBy Jeff Kinney A dance at Greg Heffley's middle school is going to be held, but he can't find someone to go with him. Finally he finds a girl from his class to go with him. That is when The Third Wheel story begins. The Third Wheel is full of jokes and interesting drawings. Ivy and Bean Make the RulesBy Annie Barrows Bean's older sister Jessie goes to a summer camp called Girl Power 4-Ever, but Bean can't join her because she is too young. So Bean and her best friend, Ivy, decide to create their own camp. At Camp Flaming Arrow, Ivy and Bean come up with all the activities and, of course, they make the rules. Their happiness and kindness will make you want to keep reading. Stick DogBy Tom Watson Stick Dog is a dog that lives in an empty pipe. He has four dog friends named Poo-Poo, Stripes, Karen and Mutt. When Stick Dog smells some delicious hamburgers, he and his friends decide to steal the food from a human family that is having a picnic in Picas-so Park. Along the way, they face a lot of funny challenges. White Fur FlyingBy Patricia Maclachlan Zoo and Alice's mother might just have the coolest job ever. She rescues Great Pyrenees dogs! But dogs aren't the only things that need to be saved. The family's new neighbour, Philfip, doesn't speak, and no one knows why. White Fur Flying is all about understanding that love can come from both inside and outside. Although it is a little sad, the book is good to read. Kids who love animals and a good story will really like it, too.
Output: Who wants to start a camp?
By genomic sequence analysis, the FOXP3 gene maps to the p arm of the X chromosome (specifically, Xp11.23).
Output: Which chromosone can you find FOXP3?
UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6.
Output: On what chromosome is ULBP2 found?
"To be or not to be".Outside the Bible, these six words are the most famous in all the literature of the world.They were spoken by Hamlet when he was thinking aloud, and they are the most famous words in Shakespeare because Hamlet was speaking not only for himself but for every thinking man and woman.To be or not to be----to live or not to live, to live richly and abundantly and eagerly, or to live dully and meanly and scarcely.A philosopher once wanted to know whether he was alive or not, which is a good question for everyone to put to himself occasionally.He answered it by saying, "I think, therefore I am." But the best definition of existence I ever saw was one written by another philosopher who said, "To be is to be in relations." If this is true, then the more relations a living thing has, the more it is alive.To live abundantly means simply to increase the range and intensity of our relations.Unfortunately, we are so constituted that we get to love our routine.But other than our regular occupation, how much are we alive? If you are interested only in your regular occupation, you are alive only to that extent.So far as other things are concerned----poetry and prose, music, pictures, sports unselfish friendships, politics, international affairs----you are dead. On the contrary, it is true that every time you acquire a new interest----even more, a new accomplishment----you increase your power of life.No one who is deeply interested in different kinds of subjects can remain unhappy.The real is the person who has lost interest. Bacon said that a man dies as often as he loses a friend.But we gain new life by contacts with new friends, and new ideas and thoughts, too.Where your thoughts are, there will be your life also.If your thoughts are limited only to your business, only to your physical welfare, only to your narrow circle of the town in which you live, then you live in a narrow restricted life.But if you are interested in the characters of a good novel, then you are living with those highly interested people; if you listen intently to fine music, you are always away from immediate surroundings and living in a world of passion and imagination. To be or not to be ---- to live intensely and richly, or merely to exist, that depends on ourselves.Let us widen and intensify our relations.While we live, let us live.
Output: What is the main idea of the passage?
Kunstgewerbeschule (''school of arts and crafts'') is the name of a type of higher schools of applied arts that existed in German-speaking countries until 1945.
Output: Which industry is Kunstgewerbeschule associated with?
Parkinson's disease is the most common neurodegenerative movement disorder. The motor impairments of Parkinson's disease are caused by the loss of dopaminergic neurons in the substantia nigra and associated with the appearance of fibrillar aggregates of -synuclein (-syn) called Lewy bodies. Approximately 90% of -syn deposited in Lewy bodies is phosphorylated at serine 129 (Ser129). In contrast, only 4% or less of total -syn is phosphorylated at this residue in the normal brain. This suggests that the accumulation of Ser129-phosphorylated -syn leads to the formation of Lewy bodies and dopaminergic neurodegeneration in Parkinson's disease. Our laboratory and others have performed experiments using in vivo models of Parkinson's disease to elucidate the role of increased Ser129 phosphorylation in -syn neurotoxicity. However, there has been a lack of consistency among these models. In this review, we summarize the main findings regarding the relationship between Ser129 phosphorylation and -syn neurotoxicity, and examine the differences among models. We further discuss the role of Ser129 phosphorylation in -syn aggregation and the future directions to test the potential of Ser129 phosphorylation as a therapeutic target for slowing the progression of Parkinson's disease.
Output: Which residue of alpha-synuclein was found to be phosphorylated in Lewy bodies?
Infective embolic retinopathy as a sequela of bacterial endocarditis is described in a 31-year-old woman with mitral valve prolapse. The infective organism, Corynebacterium minutissimum, has not been previously found to cause ocular or multisystem diseases. It is a common mucocutaneous inhabitant which causes erythrasma. In our case report both ocular involvement and septicaemia were present. The infection was confirmed by positive serial blood cultures. Mitral valve prolapse was confirmed by echocardiography. On clinical examination the retinopathy consisted of white intraretinal lesions which resolved with antibiotic therapy. By fluorescein angiography focal areas of hypofluorescence corresponding to the white fundus lesions were present. Optic disc oedema was also seen.
Output: Which bacteria causes erythrasma?
Mammalian selenium-containing proteins identified thus far contain selenium in the form of a selenocysteine residue encoded by UGA. These proteins lack common amino acid sequence motifs, but 3'-untranslated regions of selenoprotein genes contain a common stem-loop structure, selenocysteine insertion sequence (SECIS) element, that is necessary for decoding UGA as selenocysteine rather than a stop signal. We describe here a computer program, SECISearch, that identifies mammalian selenoprotein genes by recognizing SECIS elements on the basis of their primary and secondary structures and free energy requirements. When SECISearch was applied to search human dbEST, two new mammalian selenoproteins, designated SelT and SelR, were identified. We determined their cDNA sequences and expressed them in a monkey cell line as fusion proteins with a green fluorescent protein. Incorporation of selenium into new proteins was confirmed by metabolic labeling with (75)Se, and expression of SelT was additionally documented in immunoblot assays. SelT and SelR did not have homology to previously characterized proteins, but their putative homologs were detected in various organisms. SelR homologs were present in every organism characterized by complete genome sequencing. The data suggest applicability of SECISearch for identification of new selenoprotein genes in nucleotide data bases.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Several genetic disorders are characterized by normal head size at birth, followed by deceleration in head growth resulting in postnatal microcephaly. Among these are classic disorders such as Angelman syndrome and MECP2-related disorder (formerly Rett syndrome), as well as more recently described clinical entities associated with mutations in CASK, CDKL5, CREBBP, and EP300 (Rubinstein-Taybi syndrome), FOXG1, SLC9A6 (Christianson syndrome), and TCF4 (Pitt-Hopkins syndrome). These disorders can be identified clinically by phenotyping across multiple neurodevelopmental and neurobehavioral realms, and enough data are available to recognize these postnatal microcephaly disorders as separate diagnostic entities in their own right. A second diagnostic grouping, comprised of Warburg MICRO syndrome, Cockayne syndrome, and Cerebral-oculo-facial skeletal syndrome, share similar features of somatic growth failure, ophthalmologic, and dysmorphologic features. Many postnatal microcephaly syndromes are caused by mutations in genes important in the regulation of gene expression in the developing forebrain and hindbrain, although important synaptic structural genes also play a role. This is an emerging group of disorders with a fascinating combination of brain malformations, specific epilepsies, movement disorders, and other complex neurobehavioral abnormalities.
Output: Mutation of which gene is implicated in the Christianson syndrome?
Tumors of the nervous system most often occur in both children and adults as sporadic events with no family history of the disease, but they are also among the clinical manifestations of a significant number of familial cancer syndromes, including familial retinoblastoma, neurofibromatosis 1 and 2, tuberous sclerosis, and Cowden, Turcot, Li-Fraumeni and nevoid basal cell carcinoma (Gorlin) syndromes. All of these syndromes involve transmissible genetic risk resulting from loss of a functional allele, or inheritance of a structurally defective allele, of a specific gene. These genes include RB1, NF1, NF2, TSC1, TSC2, TP53, PTEN, APC, hMLH1, hPSM2, and PTCH, most of which function as tumor suppressor genes. The same genes are also observed in mutated and inactive forms, or are deleted, in tumor cells in sporadic cases of the same tumors. The nature of the mutational events that give rise to these inactivated alleles suggests a possible role of environmental mutagens in their causation. However, only external ionizing radiation at high doses is clearly established as an environmental cause of brain, nerve and meningeal tumors in humans. Transplacental carcinogenesis studies in rodents and other species emphasize the extraordinary susceptibility of the developing mammalian nervous system to carcinogenesis, but the inverse relationship of latency to dose suggests that low transplacental exposures to genotoxicants are more likely to result in brain tumors late in life, rather than in childhood. While not all neurogenic tumor-related genes in humans have similar effects in experimental rodents, genetically engineered mice (GEM) increasingly provide useful insights into the combined effects of multiple tumor suppressor genes and of gene-environment interactions in the genesis of brain tumors, especially pediatric brain tumors such as medulloblastoma.
Output: Which is the gene mutated in type 1 neurofibromatosis?
Athens will welcome the 2004 Olympic Games with open arms. Not only will the Games be returning to their birthplace, but they'll also be entering a new period of Olympic history. The International Olympic Committee (IOC) has been looking for ways to make the world's largest sporting event a bit smaller and easier for cities to host. Mexico is the only Latin American nation to have hosted the Olympics. And the games have never been held in Africa. It costs well over$4 billion to host the Olympic Games. And this is stopping many poorer countries from trying to win the bid. Cities in Africa and Latin America, with great social and money problems, cannot even begin to make the bid. So, the IOC has suggested 117 ways to make the Games smaller and easier for cities across the world. These ideas are to be put into practice soon---maybe in time for the Beijing 2008 Olympics. The IOC wants to save up to $400 million. The suggestions include limiting the number of sports to 28 and the number of athletes to 10,500. "Imagine a bus with 28 seats and some sports need to get off to give their places to other sports,"said an IOC official. Sports that might not appear in the 2008 Beijing Olympic Games included baseball, softball and the modern pentathlon (shooting, fencing, horse, jumping, swimming and running). "We think that the Olympic Games have to be made smaller, and the less costly so that they can be organized by all continents and subcontinents ,"said IOC president Jacques Rogge. "Our dream is that a continent such as Africa will be able to organize the Olympic Games."
Output: What's the main idea of the passage?
Nestin is a unique intermediate filament protein. While it is robustly expressed in developing brain, postnatal expression is limited to the brain's subventricular zone (SVZ) and endothelial cells. Reexpression occurs, however, under several pathological conditions, including injury and neoplasia. We hypothesized that nestin would be a sensitive marker of early neoplasia after transplacental exposure of rats to ethylnitrosourea (ENU). Rats of various ages were administered bromodeoxyuridine (BudR) before sacrifice, and brain sections were examined for proliferative cells and several immunohistochemical markers, including nestin. Additional rats were examined after a stab wound injury to assess the expression of two of these markers, GFAP and nestin, in reactive astrocytes. All ENU-induced brain tumors (n = 9) were classified as gliomas (astrocytomas or oligoastrocytomas) based on their histology and immunophenotype. Nestin expression was noted in all tumors examined and was present in tumor cells as well as endothelial cells. During tumor development, we consistently noted nestin-expressing cells bearing multiple processes distributed throughout brain parenchyma. Both single cells and multiple cell clusters were observed as early as postnatal day 30 in all ENU-exposed brains examined (n = 11). Such distinctive nestin-expressing cells were not seen in nestin-stained control brains or ENU-exposed brains stained for GFAP or vimentin, nor was such a cell seen in a stab wound model used to assess reactive astrocytosis. While the number of these clusters was highly variable among rats, their size increased between 30 and 90 days. The data suggest that these nestin-expressing cells represent an early stage of the neoplastic process. It remains to be determined whether these cells become apparent at 30 days of age due to "dedifferentiation" of a local resident astrocyte or astrocyte precursor cell or migration of a relatively undifferentiated precursor/stem cell from the SVZ.
Output: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
Who do you think was the most important woman of the past 100 years? Jane Addams (1860 - 1935) Addams helped the poor and worked for peace. She created shelters, education opportunities and services for people in need. In 1931, Addams became the first American woman to win the Nobel Peace Prize. Rachel Carson (1907 - 1964) Rachel Carson was born in the rural river town of Springdale, Pennsylvania in America. The popular 1962 book "Silent Spring" by Rachel Carson made people realize the dangers and the harmful effects of pollution on humans and on the world's lakes and oceans. Angela Merkel (1954 - ) In 2005, Germans chose Angela Merkel as their first woman head of the country. She had been a scientist in the past. As Germany's leader, she has had an effect on the whole world. Sandra Day O'Connor (1930 - ) When Sandra Day O'Connor finished her class at Stanford Law School, in 1952, she could not find work because she was a woman. However, she became the first woman to join the U.S. Supreme Court in 1981 after years of hard work. Margaret Thatcher (1925 - ) In 1979, Margaret Thatcher became Britain's first woman Prime Minister . She served until 1990, which made her the first British leader to serve three terms in a row. Because of her high standards and strong will, people called her Britain's Iron Lady. Marie Curie (1867-19245102534) Polish-born scientist Marie Curie discovered that some types of metal give off energy called radiation . Her research led to new medical treatments and arms. She received the Nobel Prize in Physics in 1903 and in Chemistry in 1911.
Output: Who once failed to find a job?
When you make a mistake, big or small, cherish it like it's the most precious thing in the world, because in some ways, it is. Most of us feel bad when we make mistakes, beat ourselves up about it, feel like failures, get mad at ourselves. And that's only natural. Most of us have been taught from a young age that mistakes are bad, and we should try to avoid mistakes. We've been scolded when we make mistakes--at home, school and work. Maybe not always, but probably enough times to make feeling bad about mistakes an unconscious reaction. Yet without mistakes, we could not learn or grow. If you think about it that way, mistakes should be cherished and celebrated for being one of the most amazing things in the world. They make learning possible; they make growth and improvement possible. By trial and error--trying things, making mistakes, and learning from those mistakes--we have figured out how to make electric light, to paint the ceiling of the Sistine Chapel, to fly. Mistakes make walking possible for the smallest _ , make speech possible, and make works of genius possible. Think about how we learn:We don't just consume information about something and instantly know it or know how to do it. You don't just read about painting,or writing,or computer programming,or baking, or playing the piano, and know how to do them right away. Instead, you get information about something, from reading or from another person or from observing usually...then you construct a model in your mind...then you test it out by trying it in the real world...then you make mistakes...then you revise the model based on the results of your real world experimentation...and repeat, making mistakes, learning from those mistakes, until you've pretty much learned how to do something. That's how we learn as babies and toddlers, and how we learn as adults. Mistakes are how we learn to do something new--because if you succeed at something, it's probably something you already knew how to do. You haven't really grown much from that success--at most it's the last step on your journey, not the whole journey. Most of the journey is made up of mistakes, if it's a good journey. So if you value learning,if you value growing and improving,then you should value mistakes. They are amazing things that make a world of brilliance possible.
Output: What is the best title of this passage?
Dear Daisy, Phew! I'm so glad that day is over. I was so worried all summer that my first day at my new school would be terrible. I'm really tired, but my first day at school went well and I feel much better now. First of all, we had to meet outside the school building. I was very nervous because my primary school only had 300 pupils but in the secondary school there are about 1,300. What a difference! The older pupils are really big. I felt so small waiting there in front of the school. The other problem was that I didn't know anyone. My family moved over the summer holidays, because of Dad's new job. So now I have to try to make some new friends. Standing in front of the school this morning, I wanted to be back at my old school with my old friends. The head teacher came out and told us to go into the school hall. Then he called our names out to tell us which class we were in. My class teacher is called Mrs. Black. She took us to our classroom. It's on the 5th floor and ... guess what? ... We aren't allowed to use the lift. I couldn't believe it. When we were walking up all the stairs I started talking to another boy who didn't know anyone. He said his family had moved from Hong Kong over the summer. He seemed really nice so we sat together when we got to our classroom, out of breath! He said his English was very poor but I thought it was really good. We spent all morning with Mrs. Black looking at our timetables. Everyone in the school has a different timetable--can you believe it? Half of the school is learning Spanish as a second language and the other half learns French. I'm in the Spanish group, which sounds like fun. I'm worried that I'll forget my timetable and go to the wrong room! How will anyone help me if nobody else has the same timetable as me? Lunchtime was OK. After lunch we started lessons. I had maths, which was complicated and difficult and then history, where we started to learn about ancient Greece. That looks interesting. I have to do some homework tonight to find out how the ancient Greek people lived. So far so good. I'm quite looking forward to tomorrow, even though I've got science. I hate science! Jason
Output: How did the author feel on the first day at his new school?
The purpose of this paper is to assess the reliability and validity of the Spanish version of the Davidson trauma scale (DTS-S) and to determine the prevalence and correlates of post-traumatic stress disorder (PTSD) symptoms in a non-clinical random sample of prison inmates. Probabilistic samples of 1,179 inmates from 26 penal institutions in Puerto Rico were selected using a multistage sampling design. Population estimates and correlations were obtained for PTSD, generalized anxiety and depression. The reliability, factor structure, and convergent validity of the DTS-S were assessed. Cross-validation was employed to confirm the results of the factor analyses. Using the cut-offs adopted by the scale's author, 136 (13.4 percent) of the inmates are likely to have current PTSD and 117 (11.6 percent) reach the cut-off for sub-threshold PTSD. Confirmatory factor analysis generated two factors explaining 53 percent of the variance. High reliabilities were obtained for the total scale (=0.95) and for the frequency and severity scales (=0.90 and 0.91). Significantly higher DTS-S scores were found for females (t=2.26, p<0.025), for inmates diagnosed with depression or anxiety (t=2.02, p<0.05), and those reporting suicide attempts (t=4.47, p<0.0001). Findings support that the DTS-S is a reliable and valid measure to assess PTSD symptoms in Latino inmate populations and to identify individuals at risk for the disorder that require confirmatory diagnosis and clinical interventions.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
Peter availed himself of savage tortures while investigating the incident. Many suspects were whipped to death with the knout, an extremely stout leather whip composed of numerous twisted strands. Many were stretched until their limbs broke; sophisticated iron thumbscrews were applied to the fingers and toes of some prisoners; while other had their backs slowly roasted or had their flanks and bare feet slowly torn apart with red-hot iron pincers. Peter thus induced suspect after suspect to name accomplices in a virtually unending cavalcade of forced, and likely often fake, confessions. As a result of a major investigation, 57 Streltsy were executed and the rest sent into exile. Upon his hurried return from London on 25 August 1698, Peter I ordered another investigation. Between September 1698 and February 1699, 1,182 Streltsy were executed and 601 were whipped, branded with iron, or sent into exile. The investigation and executions continued up until 1707. The Moscow regiments, which had not participated in the uprising, were later disbanded. Streltsy and their family members were removed from Moscow.
Output: What happened first: Peter I ordered another investigation or members were removed from Moscow?
While most teachers enjoy the summer break from work, other teachers try to find part-time work during that time. If you're one of those teachers who are finding part-time work during the summer, writing for children might be the right job you're looking for. During the school year, you're very familiar with children in your classroom. That means you know what children think about, how they talk and how they act. If you read stories and books for children with your students during the school year, you also know the kinds of story that children are fond of. As a teacher, you can go to the school library and find out what kinds of books students are most interested in. Also, what kinds of books seem to be in short supply? Use this information to create stories and novels. If you continue writing for children during the school year, you won't have enough time to write as much while you're teaching, but you can probably manage to work on at least one short story for children each month. Even if you don't finish these pieces during the school year, when school ends for the summer you will have lots of writing projects to finish and hand in to editors . Recently, many teachers have turned to writing for children as a part-time job. If you enjoy writing as much as you enjoy teaching, then writing for children might be the second job for you, too.
Output: Who is the passage probably written for?
Islem Chikhi (born 18 May 1985 in Blida) is an Algerian professional footballer who currently plays as a forward for Algerian Ligue 2 club Olympique de Medea.
Output: What was Islem Chikhi's team?
The rock cycle, illustrated in Figure 1.1, depicts how the three major rock types - igneous, sedimentary, and meta- morphic - convert from one to another. Arrows connecting the rock types represent the processes that accomplish these changes. Rocks change as a result of natural processes that are taking place all the time. Most changes happen very slowly. Rocks deep within the Earth are right now becoming other types of rocks. Rocks at the surface are lying in place before they are next exposed to a process that will change them. Even at the surface, we may not notice the changes. The rock cycle has no beginning or end. Rocks are classified into three major groups according to how they form. These three types are described in more detail in other concepts in this chapter, but here is a summary. The Rock Cycle. Igneous rocks form from the cooling and hardening of molten magma in many different environments. The chemical composition of the magma and the rate at which it cools determine what rock forms. Igneous rocks can cool slowly beneath the surface or rapidly at the surface. These rocks are identified by their composition and texture. More than 700 different types of igneous rocks are known. Sedimentary rocks form by the compaction and cementing together of sediments, broken pieces of rock-like gravel, sand, silt, or clay. Those sediments can be formed from the weathering and erosion of preexisting rocks. Sedimentary rocks also include chemical precipitates, the solid materials left behind after a liquid evaporates. Metamorphic rocks form when the minerals in an existing rock are changed by heat or pressure below the surface. Click image to the left or use the URL below. URL: Several processes can turn one type of rock into another type of rock. The key processes of the rock cycle are crystallization, erosion and sedimentation, and metamorphism. Magma cools either underground or on the surface and hardens into an igneous rock. As the magma cools, different crystals form at different temperatures, undergoing crystallization. For example, the mineral olivine crystallizes out of magma at much higher temperatures than quartz. The rate of cooling determines how much time the crystals will have to form. Slow cooling produces larger crystals. Weathering wears rocks at the Earths surface down into smaller pieces. The small fragments are called sediments. Running water, ice, and gravity all transport these sediments from one place to another by erosion. During sedimen- tation, the sediments are laid down or deposited. In order to form a sedimentary rock, the accumulated sediment must become compacted and cemented together. When a rock is exposed to extreme heat and pressure within the Earth but does not melt, the rock becomes meta- morphosed. Metamorphism may change the mineral composition and the texture of the rock. For that reason, a metamorphic rock may have a new mineral composition and/or texture.
Output: a rock is heated so much that it melts. what type of rock will it become?
Five boys are suspected of starting a fire that destroyed their school on the eve of the new term. Police said yesterday that five boys -- one aged 11, two 12-year-olds, one aged 13 and one 15 -- arrested on suspicion of starting the fire had been released until later this month. Parents said the five pupils all attended St Mary's. Pupils witnessed their schoolwork being destroyed in the fire at Leyland St Mary's Catholic Technology College in Lancashire. The 1950s science block was reduced to the ground in Sunday's fire, which created clouds of smoke visible for miles. It is reported that the library and sports hall were also destroyed beyond repair. Strong winds and a shortage of water prevented 125 firemen trying to bring it under control. Firefighters were expected to remain at the scene until late this afternoon. Staffs were due to attend the school yesterday for an inset day, and pupils pupils were to return for lessons after the holidays today. St Mary's head teacher Kathy McNicholas fought back the tears as she watched her school go up in flames last night. She said, "This is so upsetting to watch. It's heartbreaking. It's very _ for the staff and the children. Everyone had been looking forward to coming back for the new school year." Finding somewhere around 730 children won't be easy. A few of the staff have turned up to see if there is anything they can do and they have all been shocked and saddened by what has happened. "It's tragic because we have only just had a lot of refreshment work done to the school during the summer break. It was a big investment. The community around here very much looks after its school." Plans were being drawn up to provide alternative classrooms for 730 children, with parents warned to keep them at home for at least the rest of the week.
Output: Which part of St Mary's Catholic Technology College was burned to the ground in the fire?
Cep135 is a 135-kDa, coiled-coil centrosome protein important for microtubule organization in mammalian cells [Ohta et al., 2002: J. Cell Biol. 156:87-99]. To identify Cep135-interacting molecules, we screened yeast two-hybrid libraries. One clone encoded dynamitin, a p50 dynactin subunit, which localized at the centrosome and has been shown to be involved in anchoring microtubules to centrosomes. The central domain of p50 binds to the C-terminal sequence of Cep135; this was further confirmed by immunoprecipitation and immunostaining of CHO cells co-expressing the binding domains for Cep135 and p50. Exogenous p50 lacking the Cep 135-binding domain failed to locate at the centrosome, suggesting that Cep135 is required for initial targeting of the centrosome. Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes. This also resulted in dislocation of other centrosomal molecules, such as gamma-tubulin and pericentrin, ultimately leading to disorganization of microtubule patterns. These results suggest that Cep135 and p50 play an important role in assembly and maintenance of functional microtubule-organizing centers.
Output: Where in the cell do we find the protein Cep135?
Godfrey Pereira is a former Indian footballer who was last the head coach for Air India FC in the I-League.
Output: Which team does Godfrey Pereira play for?
Cruz Azul plays in the top division Liga MX at its home venue the Estadio Azul, located in the southwestern part of Mexico City in the Colonia Ciudad de los Deportes, adjacent the Napoles neighborhood.
Output: Where do Cruz Azul play their home games?
It has been reported that the R497K polymorphism of the epidermal growth factor receptor (EGFR) gene has attenuated functions in ligand binding, tyrosine kinase activation, and growth stimulation. On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib. We investigated the EGFR mutations and/or R497K polymorphism statuses in 225 surgically treated NSCLC cases. 192 adenocarcinoma cases were included. The presence or absence of EGFR polymorphism of exon 13 was analyzed by PCR-RFLP method. EGFR mutations at kinase domain were found from 95 of 225 lung cancer patients. In 86.2% of patients, homo- or heterozygous Lys497 allele was present. No correlation existed between R497K EGFR genotype and clinico-pathological features, such as gender, smoking status, and pathological subtypes. EGFR mutation status was not correlated with R497KEGFR genotype of lung cancers. In node-negative patients, R497KEGFR genotype was not correlated with disease outcome. In node-positive patients, however, R497K EGFR was significantly associated with better overall survival. This association was attributable to neo-adjuvant or adjuvant chemotherapy. In 46 total gefitinib treated NSCLC patients, the prognosis was not different between the EGFR wild type (GG) patients and AG+AA patients. R497KEGFR polymorphism might be associated with favorable prognosis of advanced lung cancers and correlated with chemosensitivity.
Output: Mutations in which gene determine response to both erlotinib and gefitinib?
OBJECTIVE Estimating the risk of a complicated course of Clostridium difficile infection (CDI) might help doctors guide treatment. We aimed to validate 3 published prediction models: Hensgens (2014), Na (2015), and Welfare (2011). METHODS The validation cohort comprised 148 patients diagnosed with CDI between May 2013 and March 2014. During this period, 70 endemic cases of CDI occurred as well as 78 cases of CDI related to an outbreak of C. difficile ribotype 027. Model calibration and discrimination were assessed for the 3 prediction rules. RESULTS A complicated course (ie, death, colectomy, or ICU admission due to CDI) was observed in 31 patients (21%), and 23 patients (16%) died within 30 days of CDI diagnosis. The performance of all 3 prediction models was poor when applied to the total validation cohort with an estimated area under the curve (AUC) of 0.68 for the Hensgens model, 0.54 for the Na model, and 0.61 for the Welfare model. For those patients diagnosed with CDI due to non-outbreak strains, the prediction model developed by Hensgens performed the best, with an AUC of 0.78. CONCLUSION All 3 prediction models performed poorly when using our total cohort, which included CDI cases from an outbreak as well as endemic cases. The prediction model of Hensgens performed relatively well for patients diagnosed with CDI due to non-outbreak strains, and this model may be useful in endemic settings. Infect Control Hosp Epidemiol 2017;38:897-905.
Output: Which main ribotype of Clostridium difficile is responsible of the recent outbreak?
Fallout Shelter is a free-to-play mobile simulation video game developed by Bethesda Game Studios, with assistance by Behaviour Interactive, and published by Bethesda Softworks.
Output: What business published Fallout Shelter?
It's no secret that doing good makes others happy - but did you know it can make you happy as well? According to a study, people participating in meaningful activities were happier and felt that their lives had more purpose than people who only engaged in pleasure-seeking behaviors. Try giving these four things to others to start your journey to a happier and healthier lifestyle. 1. Your Time With a busy life, it can be hard to find any time to give away. However, volunteering your time has great benefits, including making new friends and connections, learning new skills and even advancing your career. According to a paper about the link between health and volunteering, volunteering is connected with lower instances of depression and reduces the risk of dying by 22 percent. 2. Your Attention Most of us think we're good listeners, but according to psychologist Paul Donoghue, most people are aware that others don't listen as well as they could. In addition, they're not fully aware that they themselves aren't listening. When practicing mindfulness meditation , you focus on what you experience in the moment and let your thoughts and emotions pass through without judgment. Did you know that giving someone your undivided attention helps you also? When done well, active listening strengthens your focus-which is a major part of good meditation. 3. Your Compassion The psychological meaning of compassion is the ability to understand another person's emotional state. Compassion differs from empathy in that those who experience compassion not only put themselves in another person's shoes, but also want to reduce that person's suffering. A brain-imaging study showed that the brain's pleasure centers are equally active when we give money to the poor as when we receive money ourselves. 4. Your Money According to an experiment, those who spend money on other people are significantly happier than those who spend the same quantity of money on themselves. Whether or not you can offer other gifts, donating money helps make real change happen. It represents time spent, compassion and careful attention to the needs of others.
Output: Which of the four gifts matters most according to the author?
The Luchterhand Literaturverlag is a German publisher of contemporary literature based in Munich.
Output: What city is Luchterhand Literaturverlag located in?
The Madonna della seggiola or Madonna della sedia is a Madonna painting by the Italian renaissance artist Raphael, dating to c. 1513-1514 and housed in the Palazzo Pitti collection in Florence.
Output: What is the name of the place where Madonna della seggiola can be found?
The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.
Output: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
V849 Ophiuchi or Nova Ophiuchi 1919 was a nova that lit up in 1919 in the constellation Ophiuchus and reached a brightness of 7.4 mag.
Output: What constellation is V849 Ophiuchi a part of?
Chandongja Park is a multi-use stadium in Chongjin, North Korea.
Output: What is the name of the country Chandongja Park is in?
Khivi (1506--1582) also referred to as Mata Khivi or Bibi Khivi was the wife of Guru Angad Dev, second Sikh guru.
Output: What is Khivi's spouse's name?
The proposed Galore Creek mine is one of the largest undeveloped gold deposits in Canada and in the world.
Output: What product does Galore Creek mine make?
Sue Rodriguez (August 2, 1950 -- February 12, 1994) was a Canadian advocate of assisted suicide.
Output: What cause of death was listed for Sue Rodriguez?
Calcium activated gene transcription through Nuclear Factor of Activated T-cells, (NFAT) proteins, is emerging as a ubiquitous mechanism for the control of important physiological processes. Of the five mammalian NFAT isoforms, transcriptional activities of NFATs 1-4 are stimulated by a calcium driven association between the ubiquitous phosphatase calcineurin and the calcium-sensing protein calmodulin. Published in vitro evidence has suggested that other members of the calmodulin super-family, in particular the neuronal calcium sensor (NCS) proteins, can similarly modulate calcineurin activity. In this study we have assessed the ability of NCS proteins to interact directly with calcineurin in vitro and report a specific if weak association between various NCS proteins and the phosphatase. In an extension to these analyses we have also examined the effects of over-expression of NCS-1 or NCS-1 mutants on calcineurin signalling in HeLa cells in experiments examining the dephosphorylation of an NFAT-GFP reporter construct as a readout of calcineurin activity. Results from these experiments indicate that NCS-1 was not able to detectably modulate calcineurin/NFAT signalling in a live mammalian cell system, findings that are consistent with the idea that calmodulin and not NCS-1 or other NCS family proteins is the physiologically relevant modulator of calcineurin activity.
Output: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
By the mid-nineteenth century, the term "icebox" had entered the American language, but ice was still only beginning to affect the diet of ordinary citizens in the United States. The ice trade grew with the growth of cities. Ice was used in hotels, taverns , and hospitals, and by some forward-looking city dealers in fresh meat, fresh fish, and butter. After the Civil War (1861-1865), as ice was used to refrigerate freight cars, it also came into household use. Even before 1880, half of the ice sold in New York, Philadelphia, and Baltimore, and one-third of that sold in Boston and Chicago, went to families for their own use. This had become possible because a new household convenience, the icebox, a precursor of the modern fridge, had been invented. Making an efficient icebox as not as easy as we might now suppose. In the early nineteenth century, the knowledge of the physics of heat, which was essential to a science of refrigeration, was rudimentary . The commonsense notion that the best icebox was one that prevented the ice from melting was of course mistaken, for it was the melting of the ice that performed the cooling. Nevertheless, early efforts to economize ice included wrapping up the ice in blankets, which kept the ice from doing its job. Not until near the end of the nineteenth century did inventors achieve the delicate balance of insulation and circulation needed for an efficient icebox. But as early as 1803, and ingenious Maryland farmer, Thomas Moore, had been on the right track. He owned a farm about twenty miles outside the city of Washington, for which the village of Georgetown was the market center. When he used an icebox of his own design to transport his butter to market, he found that customers would pass up the rapidly melting stuff in the tubs of his competitors to pay a premium price for his butter, still fresh and hard in neat, one-pound bricks. One advantage of his icebox, Moore explained, was that farmers would no longer have to travel to market at night in order to keep their produce cool.
Output: What was essential to to make an icebox efficient according to the passage?
Disease patterns in RA vary between the sexes; the condition is more commonly seen in women, who exhibit a more aggressive disease and a poorer long-term outcome. Men, however, are more likely than women to die from extra-articular complications of rheumatoid disease. This chapter discusses the outcome and mortality studies that substantiate these conclusions and then examines the possible mechanisms that may account for them, including the HLA system, seropositivity, compliance, response to therapy and pain threshold. In particular, sex and sex hormones emerge as independent risk factors in rheumatoid disease. The epidemiological evidence points towards a peak age of onset of RA at the time of the menopause in women and towards later in life in men. Premenopausal women may fare better than postmenopausal women with RA. The possible protective effects of the oral contraceptive pill and the dramatic amelioration with pregnancy are well documented. In vivo and in vitro studies have demonstrated that sex hormones interfere with a number of the putative processes involved in the pathogenesis of RA, including immunoregulation, interaction with inflammatory mediators and the cytokine system, and direct effects on cartilage itself. All these observations point towards the importance of gonadal hormones. However, trials on the potential therapeutic use of sex hormones in RA are limited and, as yet, disappointing. Further work is necessary to determine whether the roles of sex hormones are as central protagonists or just supporting cast in the complex arena of rheumatoid disease.
Output: Is Rheumatoid Arthritis more common in men or women?