niryuu/sni-each-converted huggingface dataset:
Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development of imatinib as a therapeutic agent for CML can be attributed directly to decades of scientific discoveries. These discoveries determined that the BCR-ABL tyrosine kinase is the critical pathogenetic event in CML and an ideal target for therapy. This was confirmed in clinical trials of imatinib, with imatinib significantly improving the long-term survival of patients with CML. Continuing in this tradition of scientific discoveries leading to improved therapies, the understanding of resistance to imatinib has rapidly led to strategies to circumvent resistance. Continued studies of hematologic malignancies will allow this paradigm of targeting molecular pathogenetic events to be applied to many additional hematologic cancers.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Father of Lies is a 1998 novel by Brian Evenson.
Output: Who is the Father of Lies by?
CoNTub is a software project written in Java which runs on Windows, Mac OS X, Linux and Unix Operating systems through any Java-enabled web browser.
Output: What is the programming language for CoNTub?
On June 12, 1996, just two days after her 87th birthday, Mary Field died at her home in Fairfax, Virginia of complications from a stroke.
Output: What is the cause of death of Mary Field?
Mad Vallis is a valley in the Hellas quadrangle of Mars, with its location centered at 56.5 S and 283.9 W. It is 524 km long and was named after the Mad River in Vermont, USA.
Output: On what moon or planet can Mad Vallis be found?
Coming off their win over the Dolphins, the Falcons stayed at home, donned their throwback uniforms, and prepared for a Week 2 NFC South showdown against the Carolina Panthers. Atlanta would trail early in the first quarter as Panthers kicker John Kasay got a 38-yard field goal. Afterwards, the Falcons would answer with quarterback Matt Ryan completing a 24-yard touchdown pass to tight end Tony Gonzalez. In the second quarter, Carolina would reply with running back DeAngelo Williams getting a 3-yard touchdown run. Atlanta would strike back as Ryan completed a 10-yard touchdown pass to fullback Jason Snelling. The Panthers would creep close as Kasay nailed a 50-yard field goal, yet the Falcons would increase their lead prior to halftime as Ryan completed a 7-yard touchdown pass to wide receiver Roddy White. After a scoreless third quarter, Atlanta would get some necessary distance from Carolina as running back Michael Turner got a 1-yard touchdown run. Afterwards, Carolina mustered an 11-yard touchdown pass from quarterback Jake Delhomme to tight end Dante Rosario. On another Panthers possession, Delhomme threw an interception to cornerback Chris Houston. After yet another possession, with time running out, the Panthers tried to rally as Delhomme threw a deep desperation pass, but it resulted incomplete as cornerback Brent Grimes batted it down.
Output: Which team did the Dolphins play in week one?
Singapore did not have a native population in the true sense of the word as the population became dominated numerically by three main groups of immigrants after the British founded Singapore as a free port in the 19th century. It was estimated that when Raffles arrived in Singapore in January 1819, Singapore had about 120 Malays, 30 Chinese and some local tribes (the Orang Laut) under the rule of the Temenggung. Around 100 of these Malays had originally moved to Singapore from Johor in 1811 led by the Temenggung. Another estimate put the total population of the whole of Singapore at 1,000, mostly of various local tribes. Early census figures of Singapore show a long period of influx of migrant workers into the country, initially mostly Malays, quickly followed by the Chinese. By 1821, the population was estimated to have increased to 4,724 Malays and 1,150 Chinese. In the first census of 1824, 6,505 out of the 10,683 total were Malays and Bugis, constituting over 60% of the population. Large number of Chinese migrants started to enter Singapore just months after it became a British settlement, and they were predominantly male. In 1826, official census figures give a total population of 13,750, with 6,088 Chinese, 4,790 Malays, 1,242 Bugis, 1,021 Indians from Bengal (244) and the Coromandel Coast (777), smaller number of Javanese people (267), Europeans (87) and other peoples. The population total of Singapore increased to 16,000 in 1829, 26,000 five years later. By 1836, the Chinese at 13,749 had become the most populous ethnic group, overtaking the broad Malay grouping (12,538, including other groups such as the Bugis, Javanese, and Balinese). By the beginning of 1850, the population had reached 60,000, 24,790 of them Chinese.
Output: What was the nationality of Raffles?
ZFHX1B encodes Smad-interacting protein 1, a transcriptional corepressor involved in the transforming growth factors beta (TGFbeta) signaling pathway. ZFHX1B mutations cause a complex developmental phenotype characterized by severe mental retardation (MR) and multiple congenital defects. We compared the distribution of ZFHX1B transcripts during mouse and human embryogenesis as well as in adult mice and humans. This showed that this gene is strongly transcribed at an early stage in the developing peripheral and central nervous systems of both mice and humans, in all neuronal regions of the brains of 25-week human fetuses and adult mice, and at varying levels in numerous nonneural tissues. Northern blot analysis suggested that ZFHX1B undergoes tissue-specific alternative splicing in both species. These results strongly suggest that ZFHX1B determines the transcriptional levels of target genes in various tissues through the combinatorial interactions of its isoforms with different Smad proteins. Thus, as well as causing neural defects, ZFHX1B mutations may also cause other malformations.
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
While I was waiting to enter university,I saw advertised in a local newspaper a teaching post at a school in a suburb of London about ten miles from where I lived. Being very short of money, I applied. Three days later, a letter arrived, asking me to go to Croydon for an interview. It proved a tiring journey: a train to Croydon station; a ten-minute bus ride and then a walk of at least fifteen minutes. It was clearly the headmaster himself that opened the door. He was short and fat, with a grey-color1ed moustache,a deeply lined face and hardly any hair. He looked at me with surprised disapproval. Then he said. "You'd better come inside." Leading me into his study, he started to ask me a number of questions: what subjects I had taken in my General School Certificate;how old I was; what games I played; whether I thought games were an important part of a boy's education, etc. I said something about not attaching too much importance to them. We obviously had very little in common. The teaching arrangement filled me with fear. I was to divide the class of twenty-four boys, aged from seven to thirteen, into three groups and teach them all subjects--including art, football, cricket and so on--in turn at three different levels. Actually, I was depressed at the thought of teaching algebra and geometry--two subjects in which I had been rather weak at school. I said shyly, "What would my salary be?" "Twelve pounds a week plus lunch." Before I could speak, he got to his feet. "Now," he said, "you'd better meet my wife. She's the one who really runs this school." This was the last thing I could hear. I was young. How could my dignity allow me to work under an old woman?
Output: Which subjects was the writer poor at?
Patient adherence to many osteoporosis treatments, primarily bisphosphonates, is generally poor, thus leading to a significant reduction in antifracture efficacy. Patient perceptions about the necessity of the prescribed medication to treat osteoporosis and the concerns about the potential adverse effects are important and potentially modifiable determinants of adherence, in addition to other factors, such as difficult dosing regimens and high dosing frequency. Denosumab (Dmab) is a fully human monoclonal antibody against the receptor activator of nuclear factor-B ligand (RANKL), which, through the prevention of the RANKL/RANK interaction, inhibits osteoclast-mediated bone resorption and significantly reduces the risk of vertebral, nonvertebral, and hip fractures. It is administered subcutaneously every 6 months for the treatment of postmenopausal osteoporosis. Preference and adherence to Dmab treatment were assessed in various clinical trials. Although with some limitations, available data suggest that Dmab is preferred to bisphosphonates, produces greater satisfaction than bisphosphonates, and would be preferentially chosen for long-term treatment. Moreover, patient perceptions about the necessity of Dmab treatment clearly outweigh the concerns about the injections, and positive beliefs about treatment positively influence medication-taking behavior. According to these data, Dmab may represent a reasonable alternative to bisphosphonates, particularly for osteoporotic women in whom a suboptimal or even poor adherence to oral treatments is expected.
Output: Which is the target of the drug Denosumab?
What does the heart look like? How does it pump blood? The heart is divided into four chambers ( Figure 1.1), or spaces: the left and right atria, and the left and right ventricles. An atrium (singular for atria) is one of the two small, thin-walled chambers on the top of the heart where the blood first enters. A ventricle is one of the two muscular V-shaped chambers that pump blood out of the heart. You can remember they are called ventricles because they are shaped like a "V." The atria receive the blood, and the ventricles pump the blood out of the heart. Each of the four chambers of the heart has a specific job. The right atrium receives oxygen-poor blood from the body. The right ventricle pumps oxygen-poor blood toward the lungs, where it receives oxygen. The left atrium receives oxygen-rich blood from the lungs. The left ventricle pumps oxygen-rich blood out of the heart to the rest of the body. Blood flows through the heart in two separate loops. You can think of them as a left side loop and a right side loop. The right side of the heart collects oxygen-poor blood from the body and pumps it into the lungs, where it releases carbon dioxide and picks up oxygen. (Recall that carbon dioxide is a waste product that must be removed. It is removed when we exhale.) The left side carries the oxygen-rich blood back from the lungs into the left side of the heart, which then pumps the oxygen-rich blood to the rest of the body. The blood delivers oxygen to the cells of the body, where it is needed for cellular respiration, and returns to the heart oxygen-poor. To move blood through the heart, the cardiac muscle needs to contract in an organized way. Blood first enters the atria ( Figure 1.2). When the atria contract, blood is pushed into the ventricles. After the ventricles fill with blood, they contract, and blood is pushed out of the heart. The heart is mainly composed of cardiac muscle. These muscle cells contract in unison, causing the heart itself to contract and generating enough force to push the blood out. So how is the blood kept from flowing back on itself? Valves ( Figure 1.2) in the heart keep the blood flowing in one direction. The valves do this by opening and closing in one direction only. Blood only moves forward through the heart. The valves stop the blood from flowing backward. There are four valves of the heart. The two atrioventricular (AV) valves stop blood from moving from the ventricles to the atria. The two semilunar (SL) valves are found in the arteries leaving the heart, and they prevent blood from flowing back from the arteries into the ventricles. Why does a heart beat? The lub-dub sound of the heartbeat is caused by the closing of the AV valves ("lub") and SL valves ("dub") after blood has passed through them.
Output: what part of the heart receives oxygen-poor blood from the body?
On April 20,2013, a big and powerful earthquake attacked Ya'an, Sichuan Province. A great many buildings and houses _ a lot of people were killed and even more people lost their homes in the earthquake . Death toll from the 7.0-magnitude earthquake that hit Ya'an in southwestern China's Sichuan Province has risen to 188 (as of 18:00 pm, April 22, ), according to latest calculations by local Civil Affairs Bureau. At least 11,826 were reportedly injured in the quake while 25 are still missing, the bureau said. Experts are anticipating much less casualties in the quake than that from the 8.0 magnitude quake hit Wenchuan on May 12, 2008, also in Sichuan Province, which killed more than 80,000 and injured over 300,000. Energy released from Wenchuan earthquake would be 30 times of that from Ya'an quake, according to Zhang Xiaonan, an expert with China's Geophysical Union. Dai Junwu with Harbin-based seismological bureau expects the death toll at less than 1,000, and economic losses from the quake could reach up to 100 billion yuan. Police and expert teams have already rushed for rescue in the quick stricken areas, and the State Council has banned unauthorized rescue efforts and individual vehicles from going to the quake zone to avoid congestion . Rescue efforts were carried "timely and orderly", said Chinese Premier Li Keqiang who flew to the quicken-stricken area on Sunday, the second day of the quake. He was quoted as saying that "the current priority is to save lives".
Output: When did Ya'an earthquake occur?
The Neponset River forms the boundary between Boston's southern neighborhoods and the city of Quincy and the town of Milton.
Output: What body of water was Boston next to?
Weesp lies next to the rivers de Vecht and Smal Weesp and also next to the Amsterdam-Rhine Canal.
Output: By which body of water is Weesp located?
Coming off their divisional home win over the Panthers, the Falcons flew to Qualcomm Stadium for a Week 13 interconference duel with the San Diego Chargers. In the first quarter, Atlanta took off as kicker Jason Elam got a 35-yard field goal. The Chargers responded with RB LaDainian Tomlinson getting a 3-yard TD run, yet the Falcons stayed close with Elam getting a 40-yard field goal. In the second quarter, Atlanta regained the lead as rookie quarterback Matt Ryan completed an 18-yard TD pass to TE Justin Peelle, along with their defense forcing opposing quarterback Philip Rivers to commit intentional grounding from his own endzone, giving Atlanta a safety. In the third quarter, San Diego answered with safety Eric Weddle returning a fumble 86 yards for a touchdown (with a failed two-point conversion). In the fourth quarter, the Falcons replied with Ryan completing a 5-yard TD pass to rookie WR Harry Douglas. The Chargers tried to come back, as kicker Nate Kaeding nailed a 28-yard field goal. Atlanta's defense stiffened for the victory.
Output: How many yards was the longest field goal?
Cerruti 1881 is a brand of the fashion house Cerruti founded in 1967 in Paris by the Italian stylist and fashion producer Nino Cerruti.
Output: Who started Cerruti 1881?
Georges Bach (born 12 June 1955 in Luxembourg) is a Member of the European Parliament since 2009, representing the Christian Social People's Party in Luxembourg and the European People's Party group.
Output: Where was Georges Bach born?
Antonio Monda (born 19 October 1962) is an Italian writer, film director, essayist, and professor at New York University's Tisch School of the Arts.
Output: What is Antonio Monda's place of employment?
The Sopoaga Ministry is the 14th ministry of the Government of Tuvalu, led by Prime Minister Enele Sopoaga.
Output: Who was in charge of Sopoaga Ministry?
Microbicides are being developed in order to prevent sexual transmission of HIV. Dapivirine, a non-nucleoside reverse transcriptase inhibitor, is one of the leading drug candidates in the field, currently being tested in various dosage forms, namely vaginal rings, gels, and films. In particular, a ring allowing sustained drug release for 1month is in an advanced stage of clinical testing. Two parallel phase III clinical trials are underway in sub-Saharan Africa and results are expected to be released in early 2016. This article overviews the development of dapivirine and its multiple products as potential microbicides, with particular emphasis being placed on clinical evaluation. Also, critical aspects regarding regulatory approval, manufacturing, distribution, and access are discussed.
Output: Which infection can be prevented with Dapivirine?
Prince Azim-ush-Shan (December 15, 1664 -- March 18, 1712) was the second son of Mughal emperor Bahadur Shah I, by his second wife, Maharajkumari Amrita Bai Sahiba.
Output: Which lady gave birth to Azim-ush-Shan?
The parents of a troubled teen may feel unsure as to whom to turn to in order to find help for their child. They may feel as if they have exhausted all of their options, and sometimes they are on the verge of giving up. But there is hope. Schools for troubled teens offer discipline and in some cases, drug treatment programs that can provide important life skills, and more importantly, a fresh start. The following is a list of the most effective types of schools for troubled teens. Not every facility is a match for every child, but by knowing the differences between them, parents can make a better educated decision about where to send their teenager. Boarding Schools When a child is unable to deal with the relative freedom of a standard school day, boarding schools might be a good choice. At boarding schools, the child lives in a dorm setting, where almost every minute of the day is scheduled by school administrators. Treatment Centers When a teenager has an addiction to drugs or alcohol, a residential center that specializes in young people is an outstanding way to help them break the cycle of addiction. Treatment centers feature individual and group counseling to help identify the root causes of the drug problem and help develop the life skills needed to stay clean when the program is over. Wilderness Programs Designed to help improve the discipline and self-reliance of the child, wilderness programs send kids back to nature. By placing them in a foreign and sometimes uncomfortable setting, wilderness programs hope to improve children's behavior. Programs generally include hikes, exercise programs and team building exercises. Boot Camps Boot camps are the most extreme style of school for troubled teens. These facilities are modeled after actual military boot camps, where the individual must get into shape, work as part of a team, and follow a long, hard set of rules and regulations. However, boot camps might not be the best choice for a teen with a drug addiction.
Output: Who would be the intended readers of the passage?
The Third Fisher Ministry was the eleventh Australian Commonwealth ministry, and ran from 17 September 1914 to 27 October 1915.
Output: On what date did Third Fisher Ministry end?
Bazex syndrome, or acrokeratosis paraneoplastica, is a cutaneous paraneoplastic syndrome characterized by psoriasiform lesions associated with, usually, a squamous cell carcinoma of the upper aerodigestive tract. We present a case of Bazex syndrome associated with metastatic cervical squamous cell carcinoma with an unknown primary. The features of the condition are discussed in the light of current knowledge.
Output: Name synonym of Acrokeratosis paraneoplastica.
Human erythrocyte spectrin is an antiparallel heterodimer comprised of a 280 kDa alpha subunit and a 246 kDa beta subunit which further associates into tetramers in the red cell membrane cytoskeleton. Lateral association of the flexible rodlike monomers involves a multiple-step process that is initiated by a high affinity association near the actin-binding end of the molecule (dimer nucleation site). In this study, recombinant alpha and beta proteins comprising two or four "spectrin type" motifs with and without adjacent, terminal nonhomologous domains were evaluated for their relative contributions to dimer initiation, and the thermodynamic properties of these heterodimer complexes were measured. Sedimentation equilibrium studies showed that in the absence of the heterologous subunit, individual recombinant proteins formed weak homodimers (K(d) > 0.3 mM). When 2-motif (alpha20-21 and beta1-2) and 4-motif (alpha18-21 and beta1-4) recombinants lacking the terminal nonhomologous domains were paired with the complementary protein, high affinity heterodimers were formed in sedimentation equilibrium analysis. Both the alpha20-21/beta1-2 complex and the alpha20-21EF/betaABD1-2 complex showed stoichiometric binding with similar binding affinities (K(d) approximately 10 nM) using isothermal titration calorimetry. The alpha20-21/beta1-2 complex showed an enthalpy of -10 kcal/mol, while the alpha20-21EF/betaABD1-2 complex showed an enthalpy of -13 kcal/mol. Pull-down assays using alpha spectrin GST fusion proteins showed strong associations between all heterodimer complexes in physiological buffer, but all heterodimer complexes were destabilized by the presence of Triton X-100 and other detergents. Complexes lacking the nonhomologous domains were destabilized to a greater extent than complexes that included the nonhomologous domains. The detergent effect appears to be responsible for the apparent essential role of the nonhomologous domains in prior reports. Taken together, our results indicate that the terminal nonhomologous domains do not contribute to dimer initiation nor are they required for formation of high affinity spectrin heterodimers in physiological buffers.
Output: Alpha-spectrin and beta-spectrin subunits form parallel or antiparallel heterodimers?
Women in sub-Saharan Africa are a priority population for evaluation of new biomedical HIV-1 prevention strategies. Antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. Antiretroviral-containing vaginal microbicide rings, which release medication over a month or longer, may reduce these adherence challenges. ASPIRE (A Study to Prevent Infection with a Ring for Extended Use) is a phase III, randomized, double-blind, placebo-controlled trial testing the safety and effectiveness of a vaginal ring containing the non-nucleoside reverse transcriptase inhibitor dapivirine for prevention of HIV-1 infection. We describe the baseline characteristics of African women enrolled in the ASPIRE trial. Between August 2012 and June 2014, 5516 women were screened and 2629 HIV-1 seronegative women between 18-45 years of age were enrolled from 15 research sites in Malawi, South Africa, Uganda, and Zimbabwe. The median age was 26 years (IQR 22-31) and the majority (59%) were unmarried. Nearly 100% of participants reported having a primary sex partner in the prior three months but 43% did not know the HIV-1 status of their primary partner; 17% reported additional concurrent partners. Nearly two-thirds (64%) reported having disclosed to primary partners about planned vaginal ring use in the trial. Sexually transmitted infections were prevalent: 12% had Chlamydia trachomatis, 7% Trichomonas vaginalis, 4% Neisseria gonorrhoeae, and 1% syphilis. African HIV-1 seronegative women at risk of HIV -1 infection were successfully enrolled into a phase III trial of dapivirine vaginal ring for HIV-1 prevention.
Output: Which infection can be prevented with Dapivirine?
The film was nominated for the Academy Award for Best Picture, as well as Art Direction (Carroll Clark and Van Nest Polglase), Original Song (Irving Berlin for ''Cheek to Cheek''), and Dance Direction (Hermes Pan for ''Piccolino'' and ''Top Hat'').
Output: What award was Top Hat nominated for?
Konstantin Biebl (February 26, 1898, Slavetin -- November 12, 1951, Prague, suicide) was a Czech poet.
Output: What cause of death was listed for Konstantin Biebl?
The Spiritual Exercises of Ignatius of Loyola (Latin original: Exercitia spiritualia) (composed 1522--1524) are a set of Christian meditations, prayers and mental exercises, written by Saint Ignatius of Loyola, a 16th-century Spanish priest, theologian, and founder of the Society of Jesus (Jesuits).
Output: What group was Spiritual Exercises of Ignatius of Loyola a member of?
720 Bohlinia is a minor planet orbiting the Sun that was discovered by Franz Kaiser, a German astronomer in 1911.
Output: Who discovered the 720 Bohlinia?
Tardive dyskinesia (TD) is a movement disorder characterized by abnormal involuntary facial movements induced by chronic therapy with classical antipsychotic medications. Currently, there is no satisfactory pharmacotherapy for TD, which represents a major limitation to therapy with classical antipsychotics. In order to develop or optimize therapies for TD, and to develop new APDs with lower indices of motor side effects, the pathology underlying TD must first be understood. The use of animal models has been used to further this objective. Here, we review different preparations that have been used to model TD and discuss the contribution of neuroimaging studies conducted in these models. Studies in animal models have lead to several hypotheses of TD pathology, although none has yet emerged as the ultimate underlying cause of this syndrome. We discuss alterations in functional indices, neuron and synapse morphology and changes in specific neurotransmitter systems that have been described in animal models of TD, and outline how these findings have contributed to our understanding of antipsychotic-induced dyskinesias. We conclude that several non-mutually exclusive theories of TD are supported by animal studies, including increases in oxidative stress leading to structural and functional changes in specific neurotransmitter systems. Elucidating the mechanisms underlying TD neuropathology partly through the use of animal models will lead to the development of APDs with superior side effect profiles or more effective therapies for TD.
Output: What is the cause of Tardive dyskinesia?
FC Taraz are a Kazakhstani football club based at the Taraz Central Stadium in Taraz.
Output: Where does FC Taraz play its game?
Reckershausen is an Ortsgemeinde -- a municipality belonging to a Verbandsgemeinde, a kind of collective municipality -- in the Rhein-Hunsruck-Kreis (district) in Rhineland-Palatinate, Germany.
Output: Which country is Reckershausen in?
The Jaccard index, also known as the Jaccard similarity coefficient (originally coined coefficient de communaute by Paul Jaccard), is a statistic used for comparing the similarity and diversity of sample sets.
Output: Who made Jaccard index known?
To identify and compare the operating characteristics of existing prehospital stroke scales to predict true strokes in the hospital. We searched MEDLINE, EMBASE, and CINAHL databases for articles that evaluated the performance of prehospital stroke scales. Quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. We abstracted the operating characteristics of published prehospital stroke scales and compared them statistically and graphically. We retrieved 254 articles from MEDLINE, 66 articles from EMBASE, and 32 articles from CINAHL Plus database. Of these, 8 studies met all our inclusion criteria, and they studied Cincinnati Pre-Hospital Stroke Scale (CPSS), Los Angeles Pre-Hospital Stroke Screen (LAPSS), Melbourne Ambulance Stroke Screen (MASS), Medic Prehospital Assessment for Code Stroke (Med PACS), Ontario Prehospital Stroke Screening Tool (OPSS), Recognition of Stroke in the Emergency Room (ROSIER), and Face Arm Speech Test (FAST). Although the point estimates for LAPSS accuracy were better than CPSS, they had overlapping confidence intervals on the symmetric summary receiver operating characteristic curve. OPSS performed similar to LAPSS whereas MASS, Med PACS, ROSIER, and FAST had less favorable overall operating characteristics. Prehospital stroke scales varied in their accuracy and missed up to 30% of acute strokes in the field. Inconsistencies in performance may be due to sample size disparity, variability in stroke scale training, and divergent provider educational standards. Although LAPSS performed more consistently, visual comparison of graphical analysis revealed that LAPSS and CPSS had similar diagnostic capabilities.
Output: ROSIER scale is used for which disorder?
Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung cancers to gefitinib (Iressa), kinase inhibitor. In-frame deletions occur in exon 19, whereas point mutations occur frequently in codon 858 (exon 21). We found from sequencing the EGFR TK domain that 7 of 10 gefitinib-sensitive tumors had similar types of alterations; no mutations were found in eight gefitinib-refractory tumors (P = 0.004). Five of seven tumors sensitive to erlotinib (Tarceva), a related kinase inhibitor for which the clinically relevant target is undocumented, had analogous somatic mutations, as opposed to none of 10 erlotinib-refractory tumors (P = 0.003). Because most mutation-positive tumors were adenocarcinomas from patients who smoked <100 cigarettes in a lifetime ("never smokers"), we screened EGFR exons 2-28 in 15 adenocarcinomas resected from untreated never smokers. Seven tumors had TK domain mutations, in contrast to 4 of 81 non-small cell lung cancers resected from untreated former or current smokers (P = 0.0001). Immunoblotting of lysates from cells transiently transfected with various EGFR constructs demonstrated that, compared to wild-type protein, an exon 19 deletion mutant induced diminished levels of phosphotyrosine, whereas the phosphorylation at tyrosine 1092 of an exon 21 point mutant was inhibited at 10-fold lower concentrations of drug. Collectively, these data show that adenocarcinomas from never smokers comprise a distinct subset of lung cancers, frequently containing mutations within the TK domain of EGFR that are associated with gefitinib and erlotinib sensitivity.
Output: Mutations in which gene determine response to both erlotinib and gefitinib?
Alessio Locatelli (born 17 March 1978) is an Italian football goalkeeper.
Output: At what position on the field did Alessio Locatelli play football?
Restless in the Tides is the first full-length album by heavy metal music group Forever in Terror.
Output: Who performed Restless in the Tides?
DaDaBIK is a commercial software (formerly GPL) written in PHP for quickly creating a CRUD (create, read, update, delete) database front-end or a simple database-driven application without coding.
Output: What programming language was used to write DaDaBIK?
Juan Carlos Varela was the candidate of the Panamenista Party, but eventually supported Ricardo Martinelli in a coalition of four parties, led by Martinelli's Democratic Change party.
Output: Who led Panameñista Party?
Spinocerebellar ataxia type 3 (SCA3) is an inherited spinocerebellar ataxia caused by the expansion of trinucleotide CAG repeats in the gene encoding ataxin-3. The clinical manifestations of SCA3 include peripheral neuropathy, which is an important cause of disability in a subset of patients. Although the loss of neurones in the dorsal root ganglion (DRG) has been postulated to be the cause of this neuropathy, the precise mechanism remains to be elucidated. To clarify the clinicopathological characteristics of SCA3-associated peripheral neuropathy, we performed nerve conduction studies and histopathological analyses. Nerve conduction studies were carried out in 18 SCA3 patients. Immunohistochemical analyses of the anterior and posterior roots of the spinal cord and peripheral nerves were performed in five SCA3 patients. We also employed immunohistochemistry and immunoelectron microscopy analyses with an anti-polyglutamine antibody. The mean sensory nerve action potentials of the SCA3 patients were half of the normal values. The motor conduction velocities were decreased, and the distal latencies were also significantly prolonged in the nerves studied relative to the those in normal controls. Histopathological analyses detected axonal sprouting and myelin thinning in all cases. Ataxin-3 aggregates were found in the cytoplasm of Schwann cells in all of the SCA3 patients examined but not in control subjects. In addition to the previously reported neuronopathy, the results of the present study indicate that Schwann cells are involved in the formation of the pathogenic intracytoplasmic ataxin-3 protein aggregates in patients with SCA3-associated neuropathy.
Output: Which is the protein implicated in Spinocerebellar ataxia type 3?
There is plenty for kids and teens to do in the Syracuse area during the summer, including some great educational opportunities. Here are the top four. Rosamond Gifford Zoo Camp The zoo offers separate camps for kids. The camps for kindergarteners run from 9 am to 12:30 pm, and cost $115 for zoo members and $135 for non-members. Kids entering 7thand 8thgrades will have half a day from 1 pm to 4:30 pm. The cost is $149 for members and $160 for non-members. All camps feature numerous educational activities and animal encounters. The camps run from August 14 to August 19. Registration starts from July 10 for members and July 15 for non-members. Active Learning Services at Christian Brothers Academy From August 1 to August 5, Christian Brothers Academy will host Active Learning Services from USA Chess. Topics of learning will include Chess Camp (age 5-15), and Video Game Creation Program (age 8-15). Chess Camp promises improved chess skills through chess instructors utilizing demo boards and historic games. Half day sessions will cost $280 for the Computer Camps. A full day of Chess costs $400, and a half day of Chess followed by a half day of Computer Camps cost $430. Syracuse University Summer College From July 5thto August 12th, Syracuse University will host pre-college programs for high school students. The Summer College will offer a wide variety of programs including architecture, engineering and computer science, public communications, and eco-fashion. The programs are taught by the teachers of Syracuse University and include hands-on activities. The costs range from $2325 to $7642. The Sheldon Institute at SUNY Oswego The State University of New York will hold two-week educational enrichment programs for students entering grades2-4 from July 25 to August 5. Children will have a set program featuring art, science, technology, cultural appreciation and writing. Tuition for the programs is only $320 and a downloadable application is available.
Output: Where can children attend the largest number of programs with low cost?
Munich's current mayor is Dieter Reiter of the Social Democratic Party of Germany.
Output: Who became the leader of Munich?
Gamma-butyrobetaine dioxygenase is unique among other human 2OG oxygenases that it catalyses both hydroxylation (e.g.: L-carnitine), demethylation (e.g.: formaldehyde) and C-C bond formation (e.g.: (1-methylimidazolidin-4-yl)acetic acid).
Output: What species is Gamma-butyrobetaine dioxygenase specific to?
Nerve growth factor (NGF) is an important mediator of pain and hyperalgesia and has become a target of novel analgesic therapeutics. Tanezumab is a humanized IgG(2) antibody that binds NGF with high affinity and specificity. In a study to assess the toxicity and pharmacokinetic properties of tanezumab in adult, male and female, cynomolgus monkeys following weekly intravenous administration of 1, 10, or 30 mg/kg for up to 26 weeks (followed by an 8-week recovery period), tanezumab was well tolerated with no macroscopic or microscopic effects on those brain, spinal cord, nerve, or ganglia sections evaluated. One fifth of tanezumab-treated monkeys developed an antibody response to tanezumab that prevented maintenance of tanezumab exposure between dosing. In the antibody-negative animals, accumulation of tanezumab was observed; steady state was achieved approximately 8 weeks after the first dose of study drug, and exposure to tanezumab was approximately dose proportional with no observed difference between male and female animals. One monkey died during the study; this monkey had findings suggestive of hypersensitivity reaction. The favorable toxicity and pharmacokinetic profile of tanezumab seen in this study supports its further evaluation for the treatment of pain in clinical practice.
Output: What is the target of tanezumab?
Juvenile neuronal ceroid-lipofuscinosis (JNCL) or Batten/Spielmeyer-Vogt-Sjogren disease (OMIM #204200) is one of a group of nine clinically related inherited neurodegenerative disorders (CLN1-9). JNCL results from mutations in CLN3 on chromosome 16p12.1. The neuronal loss in Batten disease has been shown to be due to a combination of apoptosis and autophagy suggesting that CLN3P, the defective protein, may have an anti-neuronal death function. PANDER (PANcreatic-DERived factor) is a novel cytokine that was recently cloned from pancreatic islet cells. PANDER is specifically expressed in the pancreatic islets, small intestine, testis, prostate, and neurons of the central nervous system, and has been demonstrated to induce apoptosis. In this study, we over-expressed CLN3P in SH-SY5Y neuroblastoma cells and monitored the effects on PANDER-induced apoptosis. CLN3P significantly increased the survival rate of the SH-SY5Y cells in this system. This study provides additional evidence that the function of CLN3P is related to preventing neuronal apoptosis.
Output: What is the effect of a defective CLN3 gene?
Species-specific sets of chromosomes-karyotypes-are traditionally depicted as linear ideograms with individual chromosomes represented by vertical bars. However, linear visualization has its limitations when the shared collinearity and/or chromosomal rearrangements differentiating two or more karyotypes need to be demonstrated. In these instances, circular visualization might provide easier comprehension and interpretation of inter-species chromosomal collinearity. The chromDraw graphical tool was developed as a user-friendly graphical tool for visualizing both linear and circular karyotypes based on the same input data matrix. The output graphics, saved in two different formats (EPS and SVG), can be easily imported to and modified in presentation and image-editing computer programs. The tool is freely distributed under GNU General Public License (GPL) and can be installed from Bioconductor or from the chromDraw home page.
Output: Which R package is used for visualization of linear and circular karyotypes?
Offenbach Ost station was opened on 15 November 1873 on the Frankfurt-Hanau line.
Output: When did Offenbach Ost station begin?
Josef von Halban (10 October 1870, Vienna -- 23 April 1937, Vienna) was an Austrian obstetrician and gynecologist.
Output: What city was Josef von Halban born in?
Antopetitia is a genus of flowering plants in the legume family, Fabaceae.
Output: Is the taxon rank of Antopetitia species or genus?
Erythrasma is a superficial infection caused by Corynebacterium minutissimum and affects the major skin folds and the interdigital regions of the feet. It is characterized by erythematous, brown, scaly patches and maceration, and exhibits coral-red fluorescence under Wood light. The aim of this study was to determine the frequency of erythrasma in patients with interdigital lesions. An open, prospective, longitudinal, observational study was performed in a hospital in Mexico City between March and December, 2006. All patients with interdigital lesions were examined with a Wood lamp and direct examination was performed with 20 % potassium hydroxide. Cultures were done in Sabouraud dextrose agar and brain heart infusion agar, and smears were analyzed. General characteristics and concomitant diseases were recorded. We examined 73 patients, of whom 24 (32.8 %) were diagnosed with erythrasma based on coral-red fluorescence under Wood light and identification of corynebacteria by Gram staining. The disease was more common in women (83.33 %) and the mean age of the patients was 43.5 years. The main clinical findings were scaling and maceration, and the fourth interdigital web was the most commonly affected. Corynebacterium could not be isolated in any of the cases. Mycology was positive in 15 cases (62.5 %) and the following microorganisms were isolated: Candida (16.6 %), dermatophytes (12.5 %), and Trichosporon (4.1 %). Interdigital erythrasma is a common condition and can be easily confused with interdigital tinea. It persists if not treated appropriately. Rapid diagnosis is easily obtained by examination with a Wood lamp, while culture is difficult and unnecessary for diagnosis. The coexistence of erythrasma with dermatophytes and Candida should be considered when the interdigital webs are affected.
Output: Which bacteria causes erythrasma?
Rishi Prakash Tyagi became the first senior police officer in India to be convicted of first degree murder of two individuals in police custody and was sentenced to death in 2006.
Output: Which crime led to the conviction of Rishi Prakash Tyagi?
BACKGROUND Fractionated plasma separation and absorption (FPSA) is an extracorporeal liver support method that detoxifies accumulated toxins. There are limited data of its use in the treatment of Amanita phalloides intoxication. The objective of this study was to investigate whether FPSA before liver transplantation improves patients' short-term post liver transplantation survival in Amanita phalloides poisoning. MATERIAL AND METHODS The study population consisted of ten patients who had liver transplantation (LT) due to acute liver failure (ALF) caused by Amanita phalloides poisoning. Six patients were treated with FPSA before liver transplantation. All the patients who were started on FPSA were also placed on the liver transplantation list according to emergent liver transplantation criteria. RESULTS Patients treated with FPSA were in a more severe clinical condition presenting in higher mean MELD, total bilirubin, INR and ammonia along with more frequent hypoglycemia and hepatic encephalopathy grade 3/4. FPSA group had longer mean waiting time on the recipient list (3.5 vs. 1.25 days) but inferior thirty-day survival rate (16.5% vs. 100%). CONCLUSIONS When conservative medical modalities are ineffective, the only treatment for Amanita phalloides poisoning is a liver transplant. Although FPSA treated patients had inferior post-LT survival, FPSA was found to prolong the pre surgical waiting time for critically ill patients, consequently giving a chance of life-saving procedure.
Output: Which mushroom is poisonous, Amanita phalloides or Agaricus Bisporus
The Olympic Smurfs (original French title: Les Schtroumpfs Olympiques) is the eleventh album of the original French-language Smurfs comic series created by Belgian artist Peyo.
Output: What is the name of the ilustrator of the book The Olympic Smurfs?
New software is able to analyze exactly how many hairs there are in a patch of skin and could help in testing the effectiveness of baldness treatments and depilatory creams, say Australian researchers. Researchers from CSIRO Mathematical and Information Sciences in prefix = st1 /Sydneyreport their findings in the November issue of the journalSkin Research and Technology. The software, developed with a UKcompany, will make it easier for researchers developing hair removal creams to accurately assess how well they work, says Dr Pascal Vallotton. "Up to now they were counting the number of hairs that survived after treatment by hand. That's hard work and it's difficult because you may count a hair twice or you may miss it." he said. The software relies on images captured by a small flatbed scanner pressed onto the skin. Using a mathematical algorithm , the software then identifies and traces each individual hair based on an understanding of a hair's unique features, such as its straightness. The software is able to distinguish between hairs and other features on the skin such as wounds or moles . "Our skin irregularities make it difficult to say this is a hair or this is a mole," Dr Vallotton said. Comparison between earlier and later images can also determine if hair is growing quickly or slowly, he says. Unfortunately, to check the accuracy of the software, the researchers still had to adopt the old-fashioned method of counting hairs, helped by volunteers from neighboring labs who put their skins on the line for science. "We had 12 volunteers, mostly from neighboring labs, and we acquired images of hair before and after treatment," Dr Vallotton said. To ensure an accurate count, the individual hairs had to be marked off as they were counted, but after such a laborious process, the researchers were pleased to discover the software results were comparable to the manual count. Dr Vallotton says the software could also be useful in testing the effectiveness of balding treatments and counting or tracing substances other than hairs, that are long and thin and otherwise difficult to image.
Output: What plays a key role in counting the number of hairs with the software?
Dipterocarpus grandiflorus is a critically endangered common medium hardwood tree in South-East Asia and India.
Output: What is the iucn conservation status of Dipterocarpus grandiflorus?
In 1851, a French scientist named Lon Foucault took an iron sphere and hung it from a wire. He pulled the sphere to one side and then released it, as a pendulum. Although a pendulum set in motion should not change its motion, Foucault observed that his pendulum did seem to change direction relative to the circle below. Foucault concluded that Earth was moving underneath the pendulum. People at that time already knew that Earth rotated on its axis, but Foucaults experiment was nice confirmation. Imagine a line passing through the center of Earth that goes through both the North Pole and the South Pole. This imaginary line is called an axis. Earth spins around its axis, just as a top spins around its spindle. This spinning movement is called Earths rotation. An observer in space will see that Earth requires 23 hours, 59 minutes, and 4 seconds to make one complete rotation on its axis. But because Earth moves around the Sun at the same time that it is rotating, the planet must turn just a little bit more to reach the same place relative to the Sun. Hence the length of a day on Earth is actually 24 hours. At the Equator, the Earth rotates at a speed of about 1,700 km per hour, but at the poles the movement speed is nearly nothing. Earth rotates once on its axis about every 24 hours. To an observer looking down at the North Pole, the rotation appears counterclockwise. From nearly all points on Earth, the Sun appears to move across the sky from east to west each day. Of course, the Sun is not moving from east to west at all; Earth is rotating. The Moon and stars also seem to rise in the east and set in the west. Earths rotation means that there is a cycle of daylight and darkness approximately every 24 hours, the length of a day. Different places experience sunset and sunrise at different times and the amount of daylight and darkness also differs by location. Shadows are areas where an object obstructs a light source so that darkness takes on the form of the object. On Earth, a shadow can be cast by the Sun, Moon, or (rarely) Mercury or Venus. Click image to the left or use the URL below. URL:
Output: a pendulum in paris confirmed the existence of
The current President of Biaystok, elected for his first term in 2006, is Tadeusz Truskolaski won the elections as the Civic Platform's candidate, however, he has no official connection with the party.
Output: Who was elected leader of Białystok?
The Testaments of One Fold and One Shepherd is a 67-minute film produced by The Church of Jesus Christ of Latter-day Saints (LDS Church).
Output: The production company for The Testaments of One Fold and One Shepherd was what?