niryuu/sni-each-converted huggingface dataset:
At the start of World War II, the 24th Infantry was stationed at Fort Benning as school troops for the Infantry School. They participated in the Carolina Maneuvers of October - December 1941. During World War II, the 24th Infantry fought in the South Pacific Theatre as a separate regiment. Deploying on 4 April 1942 from the San Francisco Port of Embarkation, the regiment arrived in the New Hebrides Islands on 4 May 1942. The 24th moved to Guadalcanal on 28 August 1943, and was assigned to the XIV Corps. 1st Battalion deployed to Bougainville, attached to the 37th Infantry Division, from March to May 1944 for perimeter defense duty. The regiment departed Guadalcanal on 8 December 1944, and landed on Saipan and Tinian on 19 December 1944 for Garrison Duty that included mopping up the remaining Japanese forces that had yet to surrender. The regiment was assigned to the Pacific Ocean Area Command on 15 March 1945, and then to the Central Pacific Base Command on 15 May 1945, and to the Western pacific Base Command on 22 June 1945. The regiment departed Saipan and Tinian on 9 July 1945, and arrived on the Kerama Islands off Okinawa on 29 July 1945. At the end of the war, the 24th took the surrender of forces on the island of Aka-shima, the first formal surrender of a Japanese Imperial Army garrison. The regiment remained on Okinawa through 1946.
Output: What happened first: moved to Guadalcanal or arrived on the Kerama Islands?
Charles Wilson Cross died of a heart attack June 2, 1928, in Calgary.
Output: What was Charles Wilson Cross's cause of death?
The Redskins primary weapon in the backfield was running back Earnest Byner, who ranked 5th in the NFL with 1,048 rushing yards, while also catching 34 passes for 308 yards and scoring 5 touchdowns. Rookie running back Ricky Ervins was also a major asset to the running attack, rushing 145 times for 680 yards for an average of 4.7 yards per carry, while also catching 16 passes for 181 yards. And when Washington was near the goal line, they usually relied on fullback Gerald Riggs, who rushed for 248 yards and scored 11 touchdowns. The Redskins offensive line, known as "The Hogs (American football)", was led by Pro Bowl tackle Jim Lachey and guard Mark Schlereth, along with four-time Pro Bowl veteran Russ Grimm. The Hogs allowed the fewest sacks in the league with just 9, 10 sacks less than the team that allowed the second-fewest. Even Washingtons special teams unit was a big threat. Running back Brian Mitchell (running back) led the NFL in punt return yards (600) and punt return touchdowns (2) with a 13.3 yards per return average, while also gaining 583 yards returning kickoffs.
Output: Which player had more rushing yards, Ricky Ervins or Earnest Byner?
Archidamus IV (Greek: ) was a king of Sparta from 305 BC to c. 275 BC. He was the 23rd of the Eurypontids, the son of Eudamidas I and Arachidamia and the brother of Agesistrata, the nephew of Agis III and the grandson of Archidamus III. In 296 BC he was defeated by Demetrius I of Macedon.
Output: Which woman was the sister of Archidamus IV?
Paretroplus polyactis is a vulnerable species of cichlid found widely in fresh and brackish water in coastal regions and associated river basins in eastern Madagascar.
Output: How endangered does the iucn consider Paretroplus polyactis?
Flying Officer Raimund Sanders Draper, known as ''Smudge'', was an American volunteer World War II Royal Air Force (RAF) pilot of No. 64 Squadron.
Output: What is Raimund Sanders Draper's place of employment?
Sport Clube Shallon play their home games at Estadio Aluizio Ferreira.
Output: What is the common name of the place where Sport Clube Shallon plays their home games?
MicroRNAs (miRNAs) are non-coding RNAs with important roles in regulating gene expression. Recent studies indicate that transcription and cleavage of miRNA are coupled, and that chromatin structure may influence miRNA transcription. However, little is known about the relationship between the chromatin structure and cleavage of pre-miRNA from pri-miRNA. By analysis of genome-wide nucleosome positioning data sets from human and Caenorhabditis elegans (C. elegans), we found an enrichment of positioned nucleosome on pre-miRNA genomic sequences, which is highly correlated with GC content within pre-miRNA. In addition, obvious enrichments of three histone modifications (H2BK5me1, H3K36me3 and H4K20me1) as well as RNA Polymerase II (RNAPII) were observed on pre-miRNA genomic sequences corresponding to the active-promoter miRNAs and expressed miRNAs. Our results revealed the chromatin structure characteristics of pre-miRNA genomic sequences, and implied potential mechanisms that can recognize these characteristics, thus improving pre-miRNA cleavage.
Output: Which polymerase transcribes pri-miRNAs?
Posterior cruciate ligament (PCL) injuries have a reported incidence of between 3 and 37%, depending on the clinical setting. The most common mechanism of injury in motor vehicle accidents is a dashboard injury or direct force to the proximal anterior tibia. Sports related injuries result from hyperflexion of the knee with the foot typically plantarflexed. The latter mechanism is the most common cause of isolated PCL injuries, while in the trauma population as many as 95% of patients with knee injuries have combined ligamentous damage. Improved knowledge at an anatomical, biomechanical and clinical level has provided the orthopaedist with a more defined treatment algorithm. Isolated, partial PCL injuries (grades I and II) can best be treated nonoperatively while complete injuries (grade III) may require operative treatment based on clinical symptoms. All combined ligamentous injuries usually respond best with surgical management.
Output: Which ligament is most commonly injured in dashboard injury?
Mr. Flip is a 1909 American silent comedy film made by Essanay Studios, directed by Gilbert M. 'Broncho Billy' Anderson and starring Ben Turpin.
Output: What production company was involved in Mr. Flip?
New research shows how kids' brains reorganize as they learn math. All the time you spent memorizing multiplication tables may have made you a better mathematician, according to a new study. A team of scientists from Stanford University, in California, have shown how the brain reorganizes itself as kids learn math. After a certain amount of time spent practicing math, kids can put away the calculator . They don't even need to count on their fingers. They simply know the answers to subtraction , addition, and multiplication facts. The quicker kids can recall basic math facts, the easier it is for them to solve more complicated math problems. The Stanford University researchers observed the brain activity of 28 students aged 7to 9 for the study. They took scans of the students' brains as the students solved math calculations without the help of a calculator, pen or paper. A calculation--three plus four equals seven, for example--flashed on a screen. The students pushed a button to say if the answer was right or wrong. The scientists also recorded the response speed, and what parts of the brain became active as the kids pushed the button. These observations showed a process called fact retrieval . Rather than using their fingers to count, or writing out answers on a piece of paper, the students pulled the answers from memory. It's as if the answers to basic math problems are kept in a long-term storage area in the brain, which was built from repetition. "Experience really does matter," said Dr. Kathy Mann Koepeke. Children make the shift from counting to fact retrieval when they are 8 to 9 years old, the study shows. This is the time when most students are learning basic addition and subtraction. When kids have basic math facts memorized, the brain has more free space to learn more complicated math. This process has benefits for the future. The study shows as kids grow older, their answers rely more on memory and become quicker and more accurate. Less brain activity is devoted to counting. Some children make this shift quicker than others.
Output: What plays a key role in solving a math problem?
Battle.net is an internet-based online gaming, digital distribution, and digital rights management platform developed by Blizzard Entertainment.
Output: What is the name of Battle.net's developer?
Combination microbicide vaginal rings may be more effective than single microbicide rings at reducing/preventing sexual transmission of HIV. Here, we report the pre-clinical development and macaque pharmacokinetics of matrix-type silicone elastomer vaginal rings containing dapivirine and darunavir. Macaque rings containing 25 mg dapivirine, 100 mg dapivirine, 300 mg darunavir or 100 mg dapivirine+300 mg darunavir were manufactured and characterized by differential scanning calorimetry. In vitro release was assessed into isopropanol/water and simulated vaginal fluid. Macaque vaginal fluid and blood serum concentrations for both antiretrovirals were measured during 28 day ring use. Tissue levels were measured on day 28. Ex vivo challenge studies were performed on vaginal fluid samples and IC50 values were calculated. Darunavir caused a concentration-dependent reduction in the dapivirine melting temperature in both solid drug mixes and in the combination ring. In vitro release from rings was dependent on drug loading, the number of drugs present and the release medium. In macaques, serum concentrations of both microbicides were maintained between 10(1) and 10(2) pg/mL. Vaginal fluid levels ranged between 10(3) and 10(4) ng/g and between 10(4) and 10(5) ng/g for dapivirine and darunavir, respectively. Both dapivirine and darunavir showed very similar concentrations in each tissue type; the range of drug tissue concentrations followed the general rank order: vagina (1.810(3)-3.810(3) ng/g) >cervix (9.410(1)-3.910(2) ng/g) >uterus (0-108 ng/g) >rectum (0-40 ng/g). Measured IC50 values were >2 ng/mL for both compounds. Based on these results, and in light of recent clinical progress of the 25 mg dapivirine ring, a combination vaginal ring containing dapivirine and darunavir is a viable second-generation HIV microbicide candidate.
Output: Which infection can be prevented with Dapivirine?
Chettinad Palace in Karaikudi seen in the film. Natesan (Cheran) works as an engineer in electricity board in Karaikudi and leads a joint family with more 30 of his relatives living in the same house. On the other hand, Visalakshi aka Sala (Sneha) is the only daughter to her parents and she is about to complete her college education in Karaikudi. Sala feels bored while being alone and she always prefers to have her friends surrounding her. Sala's parents start searching for a groom and they get a reference for Natesan. Sala and her family meet Natesan's family in a function. Sala is surprised to see so many people living as a joint family together and she is very much impressed and agrees for the wedding. Natesan and Sala get married. Sala loves being accompanied by all the relatives in Natesan's home. When Sala and Natesan go on a honeymoon, Sala purchases gifts for everyone in the family. All the family members are also impressed seeing Sala. But Natesan feels sad that he does not get private time to spend with his wife as they are always surrounded by relatives. Now Natesan gets transferred to a hill station named Attakatti, near Pollachi. Natesan feels happy as he believes this will provide him time to spend with Sala. Although Sala feels sad leaving all her relatives, she also goes with Natesan to the hill station. Over there in the hill station, Sala feels lonely and gets bored and she longs for the life she had in Karaikudi. Their house is located in a remote place with no neighbours and friends. Natesan also gets busy with work and has very little time to spend with his wife. Slowly Sala gets psychologically disturbed due to loneliness and she behaves as if the house is filled with so many people. Also, she repairs the fan, lights etc. purposefully in their home so that the nearby electrician (Kanja Karuppu) comes to fix them and at least she gets a chance to speak to someone. She also starts recording all the sounds around her such as birds chirping, etc. and listens to the recordings when alone. One day, she records a neighbour's child's laughter sound following which the child faints. Sala is scared but the child is saved. Doctor Ramalingam (Jayaram) sees Sala and understands that she is suffering from a disorder and warns Natesan. But Natesan does not take it seriously. One day Sala consumes too much of sleeping pills to come out of her depression. But Natesan spots her lying in bed and rushes her to the hospital. Sala is saved. Ramalingam explains the disorder to Natesan and mentions that the best cure for her would be to lead a happy life surrounded by relatives. Natesan agrees and moves back to Karaikudi. The movie ends showing Natesan and Sala leading a happy life again.
Output: who experiences a love and affection of each?
Pamela Drury is single and works as a serious journalist. She spends her birthday alone and becomes lonely and reflects upon her life and the choices she made and secretly wishes she had gotten married and had children. In a box of photos of old boyfriends, she reflects upon why she broke up with one in particular, Robert Dickson, 13 years earlier. She also meets an interesting man, Ben and follows him home, only to see through his window that he is with his family and looks very happy. Shortly afterwards, she is hit by a car while crossing the street. The woman who was driving the car is also Pamela, but is Pamela Dickson; she is from an alternate universe in which she married Robert 13 years earlier. Pamela Dickson takes Pamela Drury to the Dickson family home and the two of them talk in the kitchen. Suddenly, Pamela Dickson's kids come home and she disappears, leaving the unmarried Pamela Drury in a house she has never seen before with three children she does not know. The children assume she is their mother, although they do not quite recognize her sometimes. She soon finds out that her alternate version Pamela Dickson lives in a dull marriage and writes lightweight fluff articles for a mainstream ladies magazine, rather than being the serious reporter that Drury is. She meets Ben again, but in this time-line he was never married and still mourns the loss of the great love of his life, who was killed just before their graduation from college. At first, Pamela Drury was pleased to be with Robert again after all these years apart, but she is soon unhappy and annoyed with married life, and quarrels with Robert. She embarks on an affair with Ben, not mentioning to him that she has a husband and kids (because she still doesn't think of herself as married or a mother). Ben visits her and learns the truth, and walks away angry and disappointed. Soon, Pamela Drury embraces having a family and falls for Robert again, and even stimulates him and enlivens her marriage. Then when Pamela Drury is in a restaurant bathroom, Pamela Dickson shows up again, and the two women switch back to their former lives. Pamela Dickson had been living the life of single Pamela Drury and enjoyed it but ultimately missed her husband and kids so she came back. Pamela Drury is single once more and embraces her life with a new appreciation of all that being single and having a career has to offer. She learns that while she was gone, Pamela Dickson began dating Ben, who actually is divorced from the woman she saw through the window, the same woman who alternate-Ben had thought was his soul mate. Ultimately she sees that both lives are appealing and offer a lot to appreciate.
Output: What kind of marriage does Pamela Dickson have?
Smoking bans in public places are linked with falls in childhood asthma attacks and preterm births , according to the biggest analysis of the influence of public smoking bans on child health. The finding should remove fears that such laws could have the opposite effect because they may lead people to smoke more at home. Several countries, such as Japan and Australia, have tightened laws on smoking in public places over the last few years. Meanwhile, some countries, such as the Netherlands and Germany, still allow smoking in pubs and restaurants. Only about half of US states have comprehensive bans, and there are few restrictions in poorer nations. Opponents often claim that bans could result in people smoking more at home, which would be worse for their children's health. Asthma is one of the main concerns as second-hand smoke harms children's airways in several ways. Researchers led by Jasper Been at Maastricht University Medical Centre reviewed as many as 11 studies that examined how hospital admissions for childhood asthma and preterm births changed after smoking bans came in. The studies involved more than 2.5 million births, and nearly 250,000 hospital admissions for asthma. The result shows that both asthma admissions and preterm birth rates fell by about 10 percent within a year after smoking restrictions were carried out. The effect on preterm births could also have been caused by pregnant women being more likely to quit or cut down following a public ban, says Been. But Been also says the studies could not completely prove that smoking bans directly caused these changes. However, as a matter of fact, because the analysis included several smoking bans introduced in different countries in different years, and most saw health improvements. Such findings are useful for countries and states where there is ongoing debate about how strict smoking bans should be, especially as hospital care for premature babies is so expensive. This might be one of the most important things to know in order to strengthen legislation . Other studies have shown that rates of heart attack and stroke also tend to fall after smoking bans are introduced.
Output: Laws on smoking bans in public places are going stricter in     .
Transgenic mice over-expressing a mutated form of the human amyloid precursor protein (APP, 695 isoform) bearing a mutation associated with Alzheimer's disease (V642I, so-called London mutation, hereafter APPLd2) and wild-type controls were studied at age periods (3 and 10 months) prior to the overt development of neuritic amyloid plaques. Both 3- and 10-month-old APPLd2 mice had reflex eyelid responses like those of controls, but only younger mice were able to acquire a classical conditioning of eyelid responses in a trace paradigm. In vitro studies on hippocampal slices showed that 10-month-old APPLd2 mice also presented deficits in paired-pulse facilitation and long-term potentiation, but presented a normal synaptic activation of CA1 pyramidal cells by the stimulation of Schaffer collaterals. It is proposed that definite functional changes may appear well in advance of noticeable structural alterations in this animal model of Alzheimer's disease, and that specific learning tasks could have a relevant diagnostic value.
Output: Which disease the London mutation involved in?
Topographic maps represent the locations of geographical features, such as hills and valleys. Topographic maps use contour lines to show different elevations. A contour line is a line of equal elevation. If you walk along a contour line you will not go uphill or downhill. Topographic maps are also called contour maps. The rules of topographic maps are: Each line connects all points of a specific elevation. Contour lines never cross since a single point can only have one elevation. Every fifth contour line is bolded and labeled. Adjacent contour lines are separated by a constant difference in elevation (such as 20 ft or 100 ft). The difference in elevation is the contour interval, which is indicated in the map legend. Scales indicate horizontal distance and are also found on the map legend. Old Faithful erupting, Yellowstone Na- tional Park. While the Figure 1.1 isnt exactly the same view as the map at the top of this concept, it is easy to see the main features. Hills, forests, development, and trees are all seen around Old Faithful. A bathymetric map is like a topographic map with the contour lines representing depth below sea level, rather than height above. Numbers are low near sea level and become higher with depth. Kilauea is the youngest volcano found above sea level in Hawaii. On the flank of Kilauea is an even younger volcano called Loihi. The bathymetric map pictured in the Figure 1.2 shows the form of Loihi. Loihi volcano growing on the flank of Kilauea volcano in Hawaii. Black lines in the inset show the land surface above sea level and blue lines show the topography below sea level. A geologic map of the region around Old Faithful, Yellowstone National Park. A geologic map shows the geological features of a region (see Figure 1.3 for an example). Rock units are color- coded and identified in a key. Faults and folds are also shown on geologic maps. The geology is superimposed on a topographic map to give a more complete view of the geology of the region. Click image to the left or use the URL below. URL:
Output: this type of map shows rock units and features like faults and folds.
Rev. T. Jerome Overbeck, S.J. is an American author and Christian theologian who is also a prominent priest of the Society of Jesus.
Output: What group was T. Jerome Overbeck a member of?
Rene Bliard (18 October 1932 -- 27 September 2009) was a professional French football striker who was a member of Stade de Reims in the 1950s.
Output: What is the name of the sports team whose member is René Bliard?
Community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) has become a severe health concern because of its treatment difficulties. Herein, we report the synthesis and biological evaluation of two phenazine natural products and a series of phenazines that show promising activities against MRSA with MIC values in the low micromolar range. Basic studies revealed that these compounds are bacteriostatic agents. The most active compound also displayed promising IC50 values against HaCat cells. Finally, a QSAR model was developed to understand the key structural features of the molecules.
Output: What is MRSA?
Pablo Zalba Bidegain (born 28 January 1975) is a Spanish economist and politician and has been a Member of the European Parliament (MEP), for the European People's Party, since June 2009.
Output: Which political party was Pablo Zalba Bidegain in?
Colonel Muhammadu Abdullahi Wase (died June 1996) was military administrator of Kano State in Nigeria from December 1993 --
Output: Which country is Muhammadu Abdullahi Wase a citizen of?
The Black Camel (1929) is the fourth of the Charlie Chan novels by Earl Derr Biggers.
Output: To which series does The Black Camel belong?
Our planet was born some billions of years ago. Ever since this planet has developed, it has surprised us human beings. No matter how much we human beings have developed technologically, we cannot ever create this kind of natural planet. The human race can only discover some amazing facts about it. Let us find out what some of them are. On September 13, 1922 El Azizia, a place in Libya, recorded a temperature of 136 degrees Fahrenheit. This was the highest temperature ever measured on the planet Earth. The highest waterfall in the world is Angel Falls in Venezuela, which drops from an amazing height of 3,212 feet. The waterfall drops over the edge of Auyantepui in the Canaima National Park. The gravitational pull of the Earth can be escaped if someone moves at a speed of 6.95 miles per second. At such a speed, one could travel from New York to Philadelphia in just 20 seconds. If the entire water in the world's oceans evaporated, the salt we got from these oceans could cover the entire planet with a 500-foot deep layer of salt. The deepest lake on Earth is Lake Baikal in Russia. Lake Baikal is the largest freshwater lake in the world, containing about 20% of the world's unfrozen surface fresh water. The Andes in South America spreads over 4,525 miles. This is the longest mountain range in the world. Did you know that the biggest valley in the world is the Grand Valley in Mesa County, Colorado and Grand County, Utah? It is about 30 miles (48 km) long and 5 miles (8 km) wide, along the Colorado River. The amazing facts about the earth are too many to be told completely above.
Output: Where is the longest mountain range in the world?
Think about the longest elevator ride that you've ever taken. Whether you rose five or 100 floors, it probably took less than a few minutes. Now imagine riding in an elevator higher and higher as it climbs for nearly a day. When you reach the top floor, prepare for views that are really out of this world. You'll be in space! Space elevators might sound like a crazy idea, but they're something scientists have been working on for decades. At the moment, riding in a capsule is the only way ordinary people can get to and from space. But those rides are very expensive---about $ 25 million per person per flight. Now scientists are making efforts to reduce the expense of those rides. Researchers are still figuring out the details about how a space elevator might work. One idea is stretching a very long cable -- more than 37,000 kilometers -- up to space from the earth's equator . Objects in space above the equator orbit (......) the earth at the same speed that our planet turns. A weight on the end of the cable would stretch it tight. An elevator tied to the cable could use _ to climb up and down. The only problem is that besides being long, this cable must also be very strong. Storms, including hurricanes might break it. One way to solve this problem is to stretch the cable from the moon instead of from the earth. Airplanes designed to climb higher than a typical jet might take off from the earth and link up with the cable, which would be held in place by the pull of gravity from the earth. An elevator car waiting there would then take riders the rest of the way to the moon. Fueled by solar power, the elevator could transport people and materials without much expense or effort per ride.
Output: What may make the cable stay in place on the moon?
Darth Bane is a fictional character in the Star Wars Expanded Universe.
Output: What fictional universe is Darth Bane a part of?
''Chief of Hearts'' is the eighteenth episode of The Simpsons' twenty-first season.
Output: Which show does Chief of Hearts appear on?
Quantitative real-time PCR (QPCR) has emerged as an accurate and valuable tool in profiling gene expression levels. One of its many advantages is a lower detection limit compared to other methods of gene expression profiling while using smaller amounts of input for each assay. Automated qPCR setup has improved this field by allowing for greater reproducibility. Its convenient and rapid setup allows for high-throughput experiments, enabling the profiling of many different genes simultaneously in each experiment. This method along with internal plate controls also reduces experimental variables common to other techniques. We recently developed a qPCR assay for profiling of pre-microRNAs (pre-miRNAs) using a set of 186 primer pairs. MicroRNAs have emerged as a novel class of small, non-coding RNAs with the ability to regulate many mRNA targets at the post-transcriptional level. These small RNAs are first transcribed by RNA polymerase II as a primary miRNA (pri-miRNA) transcript, which is then cleaved into the precursor miRNA (pre-miRNA). Pre-miRNAs are exported to the cytoplasm where Dicer cleaves the hairpin loop to yield mature miRNAs. Increases in miRNA levels can be observed at both the precursor and mature miRNA levels and profiling of both of these forms can be useful. There are several commercially available assays for mature miRNAs; however, their high cost may deter researchers from this profiling technique. Here, we discuss a cost-effective, reliable, SYBR-based qPCR method of profiling pre-miRNAs. Changes in pre-miRNA levels often reflect mature miRNA changes and can be a useful indicator of mature miRNA expression. However, simultaneous profiling of both pre-miRNAs and mature miRNAs may be optimal as they can contribute nonredundant information and provide insight into microRNA processing. Furthermore, the technique described here can be expanded to encompass the profiling of other library sets for specific pathways or pathogens.
Output: Which polymerase transcribes pri-miRNAs?
Hurry! Time to "steal vegetables" Don't be afraid! We are not encouraging the stealing behavior, but to tell you maybe the most popular topic from white-collars' mouth in cities. Together with "How many vegetables do you steal today," "it's harvest time for your ripe peach," "I bought you a new car today." Are there so many people in the city really have their own farms, or are they really so rich to buy someone else cars casually? The answer is obviously negative. They just play some games on Social Network Sites (SNS) like kaixin001.com. Can you imagine that more than millions of people in Chinese mainland will spend lots of time on SNS to play game and talk to friends, especially white-collars who work in the cities? Take kaixin001.com as an example, the current member of it has already hit 38 million. However, the great number of people who would like to use such SNS indicates another social problem. That is lots of people choose to escape from the reality. And SNS just offer them a Virtual space to forget the reality. Kinds of games and various of friends do give netizens lots of fun. Though indulging, dreaming, chatting and playing , it seems like people could really escape from all the upsets in reality. But virtual world is not real and no one can live in it forever, and reality is not that simple like noodling around on the internet. Since this kind of social phenomenon is so popular on the internet, people start thinking to remove it in the reality.After playing the "happy farm" game on kaixin001.com, would you like to put yourself among the real corps while smelling the fragrance of the countryside? Recently, a farm land service called "happy farm in reality" was opened in the suburbs of Shanghai where white-collar workers from around that region can experience the real farmer's life by themselves
Output: Which group are the majority playing the "Happy Farm" game?
John E. Hatley is a former Master Sergeant in the United States Army serving a 40-year sentence in the Fort Leavenworth Disciplinary Barracks for the murder of four Iraqi detainees.
Output: Which crime led to the conviction of John E. Hatley?
The Rockin' Berries are a Beat group from Birmingham, England, who had several hit records in the UK in the 1960s.
Output: What is the home city of The Rockin' Berries?
The Yellow River Piano Concerto (simplified Chinese: ; traditional Chinese: ; pinyin: Huang He xiezouqu) is a piano concerto arranged by a collaboration between musicians including Yin Chengzong and Chu Wanghua, and based on the Yellow River Cantata by composer Xian Xinghai.
Output: What instrument is Yellow River Piano Concerto scored for?
Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is a common disorder, occurring at least twice a week and causing at least moderate distress in 1.5% to 2.7% of the population. It is important for primary care physicians to be familiar with this disorder and its management. Much has changed in its management since our previous algorithm was published in 2004, including the availability of several new drugs. This revised algorithm was written by members of the Medical Advisory Board of the Willis-Ekbom Disease Syndrome Foundation based on scientific evidence and expert opinion. It considers the management of RLS/WED under intermittent RLS/WED, chronic persistent RLS/WED, and refractory RLS/WED. Nonpharmacological approaches, including mental alerting activities, avoiding substances or medications that may exacerbate RLS, and the role of iron supplementation, are outlined. Chronic persistent RLS/WED should be treated with either a nonergot dopamine agonist or a calcium channel -2- ligand. We discuss the available drugs, the factors determining which to use, and their adverse effects. We define refractory RLS/WED and describe management approaches, including combination therapy and the use of high-potency opioids.
Output: Willis-Ekbom disease is also known as?
A Free Soul became famous for a sequence where Barrymore delivers a monologue that is said to be the main reason he won the Academy Award for Best Actor that year.
Output: What was A Free Soul nominated for?
I'm trying to be a writer, but I can't even start. What should I do? Abraham, Nebraska There are many ways to come up with ideas, one of which is to write down a list of your experiences, as well as things from your imagination. When you want to write, look in the notebook for ideas. Books for writers often have good suggestions, too. One we like isSpilling Ink: A Yong Writer's Handbook by Anne Mazer and Ellen Potter. Perhaps your library has it. My classmates keep asking about a new movie I've seen. But I don't want to spoil it for them. What should I do? Corinne (by e-mail) You could ask your classmates whether they are sure they want to know and if they insist, go ahead and tell them. You may be able to give them a general idea of the movie without revealing details of the ending. I'm going to a soccer camp for youth, but I'm not sure if I'm good at soccer or if I'll make friends. Louise, New Hampshire Soccer camp is for people who share an interest in the sport. No matter what a person's ability is at the beginning, it's likely that everyone will leave camp with improved skills. Sharing a common interest may make conversations easier. Smile, be friendly, and have a sense of humor. Before long, you may find that you've made some good friends. Someone invited me to a birthday party. When I got there, kids were doing stuff I'm not interested in, like watching scary movies. I told them my mom would pick me up, so I just left. Was I rude for doing that? Sam (by e-mail) You just did the right thing and that isn't being rude. We hope you'll talk with your parents about this. They're probably proud of what you did. They may have other suggestions for you, too. Talk about different situations that might come up and what would be the best way to handle them.
Output: Who is interested inSpilling Ink: A Yong Writer's Handbook?
The murine beige mutant phenotype and the human Chediak-Higashi syndrome are caused by mutations in the murine Lyst (lysosomal trafficking regulator) gene and the human CHS gene, respectively. In this report we have analyzed a novel murine mutant Lyst allele, called Lyst(bg-grey), that had been found in an ENU mutation screen and named grey because of the grey coat color of affected mice. The phenotype caused by the Lyst(bg-grey) mutation was inherited in a recessive fashion. Melanosomes of melanocytes associated with hair follicles and the choroid layer of the eye, as well as melanosomes in the neural tube-derived pigment epithelium of the retina, were larger and irregularly shaped in homozygous mutants compared with those of wild-type controls. Secretory vesicles in dermal mast cells of the mutant skin were enlarged as well. Test crosses with beige homozygous mutant mice (Lyst(bg)) showed that double heterozygotes (Lyst(bg)/Lyst(bg-grey)) were phenotypically indistinguishable from either homozygous parent, demonstrating that the ENU mutation was an allele of the murine Lyst gene. RT-PCR analyses revealed the skipping of exon 25 in Lyst(bg-grey) mutants, which is predicted to cause a missense D2399E mutation and the loss of the following 77 amino acids encoded by exon 25 but leave the C-terminal end of the protein intact. Analysis of the genomic Lyst locus around exon 25 showed that the splice donor at the end of exon 25 showed a T-to-C transition point mutation. Western blot analysis suggests that the Lyst(bg-grey) mutation causes instability of the LYST protein. Because the phenotype of Lyst(bg) and Lyst(bg-grey) mutants is indistinguishable, at least with respect to melanosomes and secretory granules in mast cells, the Lyst(bg-grey) mutation defines a critical region for the stability of the murine LYST protein.
Output: Which syndrome is associated with mutations in the LYST gene?
Well-known companies are powered by their names and reputations. When people walk into a Pizza Hut in Tokyo, Rome, or Miami, they know exactly what they are getting. Through franchising, an investor can make use of this brand power by opening a Pizza Hut of his or her own. The risk is low, and the rewards can be big. No wonder franchising is such a successful business model. Franchising had been around for more than 100 years, but its popularity took off in the 1950s. Leading the trend were fast food restaurant like McDonald's. These days, there are franchises in more than eighty-five industries, including dry cleaning, hotels and supermarkets. It's a very big business. In the US, there are some 760,000 franchises, totaling more than $1.5 trillion in yearly revenues (income). There are two sides in a franchise: the franchisor--the owner of the business system and the franchisee--the person who licenses the system. After signing a "franchise agreement", the franchisee pays a fee. He or she also pays for equipment, supplies, and, if necessary, building costs. The total investment usually ranges from $10,000 to $1,000,000. After the business opens, the franchisee also pays a percentage of sales revenues--called a royalty--to the franchisor. Marking fees must also be paid. In return, the franchisee receives many benefits. Training is among the most common ones. It includes everything from dealing with customers to understanding the company's standards. The franchisor also handles advertising. On top of that, there's the benefit of the brand reputation that the company has built up. All of these benefits make the risk of opening a franchise much smaller than that of starting a business from scratch. However, a franchise can also have drawbacks. If a customer at a single restaurant gets sick, it may hurt every franchise in the system. Running a franchise also means closely following the company's standards. So, one has to give up a degree of independence. You have to do things their way and trust that the system will work. If you want to earn a lot of money from the business, you have to work hard. Also, remember that the monthly royalty must be paid, even if you are losing money. However, there are thousands of opportunities in franchising. They will surely grow as brand recognition becomes more important in the global economy .
Output: What is the most important factor to make a franchise successful?
Ljudevit Jonke (29 July 1907 -- 15 March 1979) was a Croatian linguist.
Output: What was Ljudevit Jonke's language?
Interleukin-6 (IL-6) has emerged as a key factor in the pathogenesis of the atypical lymphoproliferative disorder Castleman's disease (CD). Siltuximab is a new anti-IL-6, chimeric monoclonal antibody with potential therapeutic benefit in patients with CD. We report interim results from an open-label, dose-finding, seven-cohort, phase I study in which patients with symptomatic, multicentric or unresectable, unicentric CD received siltuximab at 1-, 2-, or 3-week intervals. The main efficacy end point of clinical benefit response (CBR) was defined as a composite of clinical and laboratory measures relevant to the management of CD. In addition, radiologic response was independently assessed by using modified Cheson criteria. Eighteen (78%) of 23 patients (95% CI, 56% to 93%) achieved CBR, and 12 patients (52%) demonstrated objective tumor response. All 11 patients (95% CI, 72% to 100%) treated with the highest dose of 12 mg/kg achieved CBR, and eight patients (73%) achieved objective tumor response. Overall objective-response duration ranged from 44 to > or = 889 days, and one patient had complete response for > or = 318 days. Hemoglobin increased markedly in 19 patients (median increase, 2.1 g/dL; range, 0.2 to 4.7 g/dL) in the absence of transfusion or erythropoiesis-stimulating agents. No dose-limiting toxicity was reported, and only three patients had grade 3 or higher adverse events after a median exposure of 331 days (range, 1 to 1,148 days). These interim results strongly suggest that siltuximab is an effective treatment with favorable safety for the management of CD. An additional study is planned to fully evaluate safety and efficacy at the recommended dose of 12 mg/kg every 3 weeks.
Output: Which interleukin is blocked by Siltuximab?
Jose Lamberto Diaz Nieblas (born 27 August 1954) is a Mexican politician formerly affiliated to the Institutional Revolutionary Party.
Output: What political party is Lamberto Díaz Nieblas a memeber of?
Dorothea Wieck (3 January 1908, Davos, Switzerland -- 19 February 1986, Berlin, West Germany) was a German theatre and film actress.
Output: What city did Dorothea Wieck live when he died?
3-Methyladenine DNA glycosylase II (AlkA) is a DNA-repair enzyme that removes alkylated bases in DNA via the base-excision repair (BER) pathway. The enzyme belongs to the helix-hairpin-helix (HhH) superfamily of DNA glycosylases and possesses broad substrate specificity. In the genome of Deinococcus radiodurans, two genes encoding putative AlkA have been identified (Dr_2074 and Dr_2584). Dr_2074 is a homologue of human AlkA (MPG or AAG) and Dr_2584 is a homologue of bacterial AlkAs. Here, the three-dimensional structure of Dr_2584 (DrAlkA2) is presented and compared with the previously determined structure of Escherichia coli AlkA (EcAlkA). The results show that the enzyme consists of two helical-bundle domains separated by a wide DNA-binding cleft and contains an HhH motif. Overall, the protein fold is similar to the two helical-bundle domains of EcAlkA, while the third N-terminal mixed / domain observed in EcAlkA is absent. Substrate-specificity analyses show that DrAlkA2, like EcAlkA, is able to remove both 3-methyladenine (3meA) and 7-methylguanine (7meG) from DNA; however, the enzyme possesses no activity towards 1,N(6)-ethenoadenine (A) and hypoxanthine (Hx). In addition, it shows activity towards the AlkBdioxygenase substrates 3-methylcytosine (3meC) and 1-methyladenine (1meA). Thus, the enzyme seems to preferentially repair methylated bases with weakened N-glycosidic bonds; this is an unusual specificity for a bacterial AlkA protein and is probably dictated by a combination of the wide DNA-binding cleft and a highly accessible specificity pocket.
Output: What type of DNA repair pathways is initiated by AlkA glycosylase?
Harry Hinde was the son of Edmund C. Hinde and Phobe Martin Hinde.
Output: Who was the male parent of Harry Hinde?
The Bears hosted the 6-5 Seattle Seahawks in Week 13, who had lost five of their first six road games. The Bears started the game strong, with Brian Urlacher forcing Marshawn Lynch to fumble, and the ball was recovered by Kelvin Hayden, and Jay Cutler eventually hit Earl Bennett on a 12-yard touchdown pass. The Bears would later fail twice to expand their lead; first, Lovie Smith called for Michael Bush to run up the middle on fourth-and-one at the Seattle 15, and he was stopped for no gain. On the second occasion, Bennett dropped a potential 62-yard touchdown pass. The Seahawks capitalized on the two blunders, with rookie quarterback Russell Wilson hitting Golden Tate on a 49-yard pass, and eventually scored on Lynch's 4-yard touchdown run. Wilson would complete 23 of 37 passes for 293 yards with two touchdowns and a 104.9 passer rating while rushing for 71 yards on nine carries. Seattle then took the lead on Steven Hauschka's 31-yard field goal to close the half. Seattle would have scored a touchdown on the previous play, but Braylon Edwards dropped the potential 10-yard touchdown pass in the end zone. In the third quarter, Chicago regained the lead on Cutler's 12-yard touchdown pass to Matt Forte, but Wilson would lead the Seahawks 97 yards to take back the lead on a touchdown pass to Tate. Cutler would then hit Brandon Marshall on a 56-yard pass to set up Robbie Gould's game-tying 46-yard field goal. In overtime, the Seahawks won the toss, and Wilson took the offense 80 yards, and threw the game-winning touchdown pass to Sidney Rice. On the play, Major Wright hit Rice while he was catching the ball, appearing to knock Rice unconscious and the ball out of his hands, but the review upheld the touchdown, giving Seattle the victory. The loss dropped Chicago down to 8-4, once again tying them with the Packers for the NFC North lead. The 459 yards allowed are the most by the team all season. This would mark Urlacher's final game in a Bears' uniform. Urlacher was inactive for the final four games of the 2012 season, and he retired from the NFL on May 22, 2013.
Output: Who threw the game winning score?
Gotham City's geography, like other fictional cities' geographies in the DC Universe, has varied over the decades, because of changing writers, editors, and storylines.
Output: What type of universe is Gotham City a fictional character in?
Selenocysteine, a selenium-containing analog of cysteine, is found in the prokaryotic and eukaryotic kingdoms in active sites of enzymes involved in oxidation-reduction reactions. Its biosynthesis and cotranslational insertion into selenoproteins is performed by an outstanding mechanism, implying the participation of several gene products. The tRNA(Sec) is one of these. In eukaryotes, its transcription mode by RNA polymerase III differs from that of classical tRNA genes, both at the level of the promoter elements and transcription factors involved. In addition, enhanced transcription is afforded by a newly characterized zinc finger activator. Not only transcription of the gene, but also the tRNA(Sec) itself is atypical since its 2D and 3D structures exhibit features which set it apart from classical tRNAs. Decoding of eukaryotic selenocysteine UGA codons requires a stem-loop structure in the 3'UTR of mRNAs, the selenocysteine insertion sequence (SECIS) element. Structure probing and sequence comparisons led us to propose a 2D structure model for the SECIS element, containing a novel RNA motif composed of four consecutive non-Watson-Crick base-pairs. A 3D model, rationalizing the accessibility data, was elaborated by computer modeling. It yields indicative or suggestive evidence for the role that could play some conserved residues and/or structural features in SECIS function. These might act as signals for interaction with SBP, the SECIS binding protein that we have characterized.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
The management of pain associated with chronic musculoskeletal conditions represents a significant challenge for the clinician. There remains a need for novel medications that have a significant analgesic benefit and are also safe and well tolerated. Both pre-clinical and clinical data have provided evidence of the role of nerve growth factor (NGF) in a multitude of pain eliciting conditions. Therefore, the development of monoclonal antibodies to NGF for chronic painful musculoskeletal conditions has generated interest. Areas covered: This manuscript is a review that examines both the pharmacological properties and clinical studies of tanezumab, the most widely studied antibody to NGF, for management of osteoarthritis (OA) and low back pain. In addition, the safety and tolerability profile and development history of tanezumab are also discussed. Expert opinion: Most studies provide strong support for the ability of tanezumab to provide clinically meaningful pain relief in individuals with these conditions, with longer-term studies suggesting durability of effect. The adverse event profile appears favorable, assuming the risk mitigation strategies are effective at reducing the incidence of joint-related side effects. Further data are being collected to define the optimal dose and dosing strategy in both OA and chronic low back pain.
Output: What is the target of tanezumab?
The Quartz Mountain mine is one of the largest gold mines in Canada and in the world.
Output: What type of product does Quartz Mountain mine produce?