niryuu/sni-each-converted huggingface dataset:
The company had an IPO on the NASDAQ in 1996 and in 1997 Europe's largest telecommunications company, Deutsche Telekom, bought a 21.1 percent stake in VocalTec for $48.3 million, in addition to purchasing $30 million in telephony products, services, and support over the following two-and-a-half years.
Output: What stock exchange is VocalTec associated with?
The Oude Maasje (''Little Old Meuse'') is a former distributary of the river Maas (or Meuse), which runs parallel to the current canalised Bergse Maas.
Output: What is Oude Maasje a tributary of?
Trying to snap a three-game losing streak, the 49ers flew to Giants Stadium for a Week 7 brawl with the New York Giants. With QB Alex Smith still recovering from a shoulder injury, back-up Trent Dilfer once again got the start. In the first quarter, the Niners trailed early as Giants QB Eli Manning hooked up with WR Amani Toomer on a 4-yard TD pass (with a missed PAT) for the only score of the period. In the second quarter, San Francisco took the lead with Dilfer completing a 17-yard TD pass to WR Arnaz Battle. However, New York responded with RB Brandon Jacobs getting a 5-yard TD run, while kicker Lawrence Tynes nailed field goals of 29 and 39 yards. In the third quarter, things got worse for the Niners as Giants DE Osi Umenyiora sacked Dilfer, causing a fumble, picked up the loose ball, and ran 75 yards for a touchdown. San Francisco would manage to get a safety as FB Moran Norris blocked a punt, which went out of bounds in the endzone. In the fourth quarter, New York sealed its win with Manning completing a 2-yard TD pass to TE Jeremy Shockey. The Niners ended its day with Dilfer completing a 1-yard TD pass to WR Darrell Jackson (with a failed 2-point conversion).
Output: Which receiver had the longest touchdown reception of the game?
Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes with H2A.Z in an ATP-dependent manner. Here, we show that promoter-proximal nucleosomes are highly heterogeneous for H2A.Z in Saccharomyces cerevisiae, with substantial representation of nucleosomes containing one, two, or zero H2A.Z molecules. SWR1-catalyzed H2A.Z replacement in vitro occurs in a stepwise and unidirectional fashion, one H2A.Z-H2B dimer at a time, producing heterotypic nucleosomes as intermediates and homotypic H2A.Z nucleosomes as end products. The ATPase activity of SWR1 is specifically stimulated by H2A-containing nucleosomes without ensuing histone H2A eviction. Remarkably, further addition of free H2A.Z-H2B dimer leads to hyperstimulation of ATPase activity, eviction of nucleosomal H2A-H2B, and deposition of H2A.Z-H2B. These results suggest that the combination of H2A-containing nucleosome and free H2A.Z-H2B dimer acting as both effector and substrate for SWR1 governs the specificity and outcome of the replacement reaction.
Output: Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
Moscow Sheremetyevo International Airport If You've Lost Personal Belongings *On Board --Contact the airline's representatives *At the Airport --Contact: --Sheremetyevo Police Department ......+7(495)578-22-55 --Unclaimed luggage storage room in Terminal C ......+7(495)578-23-26 --Unclaimed luggage storage room in Terminal D ......+7(499)500-65-52(domestic flights) ......+7(495)753-86-41(international flights) When collecting Lost and Found items, you shall have an identification document, a boarding pass or a ticket, and also indicate the place where the items were lost and prove they are yours. If Your Luggage Is Lost or Damaged Before leaving the arrival area, please turn to the Lost and Found counter to file a report. The written claim shall be submitted to the airline company not later than seven days from the time when the luggage was to be collected. If your luggage is not found within twenty-one days of the time when the claim was filed, you have the right to claim damages in the amount of not more than 600 rubles per kilogram. Amount refunded for the hand luggage lost through the fault of an airline is not more than 11, 000 rubles regardless of its weight. Amount refunded for damaged luggage is calculated based on the same tariffs . Keep your flight documents (a ticket, boarding pass, luggage tag, and delayed luggage report filed at the airport) until the end of the procedure for searching for your luggage. Current information on luggage-tracing results ......+7(495)578-76-65 Lost and Found service of Aeroflot Russian Airlines ......+7(495)544-33-25(from 9:00- 20:00) +7(495)753-86-41(24 hours) For further information please contact the airline.
Output: What should you do if you find your personal possessions lost on board?
Spanish National Liberation Front (Spanish: Frente Espanol de Liberacion Nacional), better known by its acronym FELN, was a Spanish Republican antifascist opposition group based in Belgium and France active between 1963 and 1970.
Output: What city is Spanish National Liberation Front located in?
Cargolux Airlines International S.A., trading as Cargolux, is a cargo airline with its head office at Luxembourg Findel Airport in Sandweiler, Luxembourg.
Output: What airport is Cargolux associated with?
Julien Malzieu (born 4 May 1983 in Le Puy-en-Velay, Auvergne) is a French rugby union and sevens player for Montpellier in the Top 14 competition.
Output: The sport Julien Malzieu is associated with is?
Michael (John Travolta) is not a stereotypical archangel. He epitomizes the freedom that an angel might command if living among mere mortals. As the tagline says, "He's an angel, not a saint."Two reporters, Frank Quinlan (William Hurt) and Huey Driscoll (Robert Pastorelli), one cynical and the other innocent, work for a tabloid newspaper in Chicago. ("Quinlan" is a nod to one of the writers of the same name.) They travel to a sleepy hamlet in Iowa because Quinlan has received a letter from a woman, Pansy Milbank, (Jean Stapleton) who has an angel for tenant and he is able to convince his editor (Bob Hoskins) that they should visit her at the Milk Bottle Motel. She dies before their very eyes, and they "persuade" Michael to accompany them to Chicago. Traveling with them is an alleged angel expert, Dorothy Winters (Andie MacDowell) with whom they were saddled by their editor.Michael is in control of the entire trip. They stop when he says so because he causes their tire to go flat. He leads them in a fight in a bar for which they are jailed one night. And he resurrects the dog, Sparky, after it is runover by a truck.Throughout the story, there is romantic tension between the angel expert and Quinlan, the cynical reporter and Michael engineers their romance to the very end.The movie's climax comes when they finally arrive in Chicago and Michael breathes his last looking up at the Sears Tower. (Michael has a fascination for the biggest and tallest things in the world.) Michael wasn't dying; but he was exiting earth for his last time. Meanwhile, the angel expert is exposed as a spy for the manipulative editor, and she confesses that she was after Huey's job. In truth, she is a dog expert who was sent on the trip to befriend Sparky. Quinlan, who at one point was moving out of his cynicism, regresses and the story almost ends with the three traveling companions going their separate ways, knowing they had journeyed with an angel, but not understanding exactly what it meant.Finally, one night, Quinlan spots a figure that he thinks is Michael (who was lying about it being his last visit), and begins following him rapidly through the streets. He rounds one corner and careens into Dorothy, who apparently was following a Michael-clone herself. Their faith is restored, and their love blossoms once more. "Marry me, Dorothy," says Quinlan. "Yes," she replies. Then the scene freezes, and out pop Michael and Pansy Milbank -- we're left to ponder whether she became an angel when she died earlier, or that she was an angel all along -- and they dance through the frozen people until they merge with the light emanating from a car's headlights.
Output: Where is Michael residing?
Somharuthai Jaroensiri is a retired female badminton player from Thailand.
Output: What is Somharuthai Jaroensiri's gender?
Many different cellular pathways have evolved to protect the genome from the deleterious effects of DNA damage that result from exposure to chemical and physical agents. Among these is a process called transcription-coupled repair (TCR) that catalyzes the removal of DNA lesions from the transcribed strand of expressed genes, often resulting in a preferential bias of damage clearance from this strand relative to its non-transcribed counterpart. Lesions subject to this type of repair include cyclobutane pyrimidine dimers that are normally repaired by nucleotide excision repair (NER) and thymine glycols (TGs) that are removed primarily by base excision repair (BER). While the mechanism underlying TCR is not completely clear, it is known that its facilitation requires proteins used by other repair pathways like NER. It is also believed that the signal for TCR is the stalled RNA polymerase that results when DNA damage prevents its translocation during transcription elongation. While there is a clear role for some NER proteins in TCR, the involvement of BER proteins is less clear. To explore this further, we studied the removal of 7-methylguanine (7MeG) and 3-methyladenine (3MeA) from the dihydrofolate reductase (dhfr) gene of murine cell lines that vary in their repair phenotypes. 7MeG and 3MeA constitute the two principal N-methylpurines formed in DNA following exposure to methylating agents. In mammalian cells, alkyladenine DNA alkyladenine glycosylase (Aag) is the major enzyme required for the repair of these lesions via BER, and their removal from the total genome is quite rapid. There is no observable TCR of these lesions in specific genes in DNA repair proficient cells; however, it is possible that the rapid repair of these adducts by BER masks any TCR. The repair of 3MeA and 7MeG was examined in cells lacking Aag, NER, or both Aag and NER to determine if rapid overall repair masks TCR. The results show that both 3MeA and 7MeG are removed without strand bias from the dhfr gene of BER deficient (Aag deficient) and NER deficient murine cell lines. Furthermore, repair of 3MeA in this region is highly dependent on Aag, but repair of 7MeG is equally efficient in the repair proficient, BER deficient, and NER deficient cell lines. Strikingly, in the absence of both BER and NER, neither 7MeG nor 3MeA is repaired. These results demonstrate that NER, but not TCR, contributes to the repair of 7MeG, and to a lesser extent 3MeA.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
Francois Taillandier (born in 1955, Clermont-Ferrand, France) is a French writer portraying the French contemporary society.
Output: What was the native language of François Taillandier?
Rotterdam Centrum is bounded by the emplacement of the Rotterdam Centraal railway station and the Goudsesingel in the North, the Tunneltraverse of the Henegouwerlaan and 's-Gravendijkwal in the West, the Nieuwe Maas River in the South and the Oostplein in the East.
Output: Which is the body of water by Rotterdam Centrum?
Ehlers-Danlos syndrome (EDS), a heterogeneous group of inheritable connective tissue disorders, is attributed to mutations in connective tissue genes. These mutations cause defects in collagen. Collagen, a connective tissue protein that acts like glue, gives strength to the body and provides support and elasticity for movement. Thus, the altered gene affects the mechanical properties of skin, joints, ligaments, and blood vessels. Ehlers-Danlos syndrome is transmitted through autosomal dominant, autosomal recessive, or x-linked patterns of inheritance. The life expectancy of an affected infant varies with the type of EDS. This article provides an overview of the 6 major classifications of EDS, their unique clinical presentations, a focused physical assessment guide, considerations for nursing care, and resources for parents. Ehlers-Danlos syndrome can be a potentially debilitating syndrome. It requires preventative and protective measures starting at birth to preserve joint function to improve infant outcomes. Caring for patients with EDS requires an understanding of the potential associated complications to help minimize the physical and emotional impact of the syndrome and improve the quality of life for affected individuals.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
The TV science-fiction seriesStar Trekno longer looked far-fetched as four men and four women in black space-suits locked themselves into a giant hi-tech greenhouse, known as a 'biosphere', in the Arizona desert yesterday for a two-year study of the environment. As dawn broke over the Santa Catalina mountains, the eight waved goodbye to television cameras. Edward Ross, their multibillionaire sponsor from a Texas oil family, closed the door of the $150 million structure, with its mini-ocean, marsh, desert, savanna, rain-forest and 3,800 plant and animal species designed to allow the team to recreate Earth and its ecosystems. The so-called Biosphere 2 is the latest of a dozen environmental projects started by the self-titled 'ecopreneur'. The project's main aim is to set up a self-sustaining community for possible use in a spaceship or on another planet. The crew members must plant, harvest and process their food on a half-acre farm in the seven-storey glass and metal structure, while conducting a series of experiments. 'We will be custodians of our new little world,' said Abigail Mayer, aged 31, a US marine biologist on the team, her voice choking with emotion. 'It is a brave new step.' Many scientists, however, are more than skeptical. They point out that the largest closed ecosystem which survived more than a few days was smaller than a football. It was developed at the University of Miami and contained only shrimp, algae and other micro-organisms. Critics have also accused Mr. Ross of being more interested in producing a profitable theme park than in carrying out serious scientific research. Hundreds of tourists visited the site daily in the summer before it was occupied by the team. They paid $9.95 to enter and all stopped at the souvenir shop.
Output: What's the location of the project?
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of inherited connective tissue disorders characterized by tissue fragility, hyperelasticity of the skin and joint hypermobility. This phenotype, accompanied by kyphoscoliosis and/or ocular fragility, is present in patients with the autosomal recessive type VI form of EDS. These patients have significantly decreased levels of lysyl hydroxylase (LH) activity, due to mutations in the LH1 gene. LH hydroxylates specific lysine residues in the collagen molecule that are precursors for the formation of cross-links which provide collagen with its tensile strength. No disorder has been directly linked to decreased expression of LH2 and LH3, two other isoforms of LH. This study describes 3 patients with mixed phenotypes of EDS, who have significantly decreased mRNAs for LH2, but normal levels of LH1 and LH3 mRNAs, in their skin fibroblasts. In contrast to the effect of LH1 deficiency in EDS VI patients, the decreased expression of LH2 does not affect LH activity, bifunctional collagen cross-links (measured after reduction as dihydroxylysinonorleucine (DHLNL) and hydroxylysinonorleucine (HLNL)), or helical lysine hydroxylation in these cell lines. Sequence analysis of full length LH2 cDNAs and 1kb of the promoter region of LH2 does not show mutations that could explain the decreased expression of LH2. These results suggest that the deficiency of LH2 in these fibroblasts may be caused by changes in other factors required for the expression of LH2.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.
Output: What is the characteristic domain of histone methyltransferases?
Dasatinib is a dual Abl/Src tyrosine kinase inhibitor (TKI) designed as a prototypic short-acting BCR-ABL-targeted TKI that inhibits BCR-ABL with greater potency compared with imatinib, nilotinib, bosutinib, and ponatinib and has been shown to have potential immunomodulatory effects. Dasatinib is approved for the treatment of all phases of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to prior imatinib treatment and first-line treatment for CML in chronic phase. In this article, the development of dasatinib as a treatment for patients with CML is reviewed. This is a review of the relevant literature regarding dasatinib development in CML (2003-2013). Dasatinib demonstrates efficacy against most BCR-ABL mutations arising during imatinib therapy and is effective in treating patients with imatinib resistance due to other mechanisms. Randomized trial data show that first-line dasatinib provides superior responses compared with imatinib and enables patients to achieve early, deep responses correlated with improved longer-term outcomes. Dasatinib has a generally acceptable safety profile, with most adverse events (AEs) proving manageable and reversible. Cytopenias are commonly observed with dasatinib, and some nonhematologic AEs including pleural effusion have been consistently reported. Dasatinib is an effective treatment option for patients with CML.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in Homo sapiens on chromosome 3.
Output: What is the name of Dystroglycan's chromosome?
Rain Vessenberg (born 27 November 1975) is a retired football (soccer) goalkeeper from Estonia.
Output: What position did Rain Vessenberg have on the rugby field?
In this phase 2 proof-of-concept study we examined the safety and efficacy of selexipag, an orally available, selective prostacyclin receptor (IP receptor) agonist, as a treatment for pulmonary arterial hypertension (PAH). 43 adult patients with symptomatic PAH (receiving stable endothelin receptor antagonist and/or a phosphodiesterase type-5 inhibitor therapy) were randomised three to one to receive either selexipag or placebo. Dosage was up-titrated in 200-g increments from 200 g twice daily on day 1 to the maximum tolerated dose by day 35 (maximum allowed dose of 800 g twice daily). Change in pulmonary vascular resistance at week 17 expressed as a percentage of the baseline value was the primary efficacy end-point, and was analysed in the per protocol set first and then in the all-treated set to assess robustness of results. A statistically significant 30.3% reduction in geometric mean pulmonary vascular resistance was observed after 17 weeks' treatment with selexipag compared with placebo (95% confidence limits -44.7- -12.2; p=0.0045, Wilcoxon rank sum test). This was supported by a similar result from the all-treated set. Selexipag was well tolerated with a safety profile in line with the expected pharmacological effect. Our results encourage the further investigation of selexipag for the treatment of PAH.
Output: Selexipag is used for which disease?
Some fish may contain harmful chemicals, which can be the result of both natural causes and water pollution. Mercury is a poisonous chemical, which occurs naturally in oceans and the Earth's crust , but also comes from man-made sources, such as farm chemicals, burning garbage, oil, coal, etc. Polyclilorinated bipheuyls (PCBs), a group of chemicals, can also be found in some fish. These man-made chemicals were used in many industries until 1977, when they were banned. PCBs were released or leaked into (lie tar and water and have bear transported around the globe. How do mercury and PCBs end up in fish and the food supply? When they arc released into the air, they attach themselves to particles .These particles settle on the ground and in the water and are eventually eater by micro-organisms. Small fish cat the micro-organisms, and large fish eat the small fish and on up the food chain. Because they can negatively affect your health, the U.S. Eavirotunental Protectioc Agency advises that kids younger than 15 years old avoid fish that cortain high levels of mercury and PCBs. These include shark, swordfish, king rrnackerel, and tilefish. There are also many types of fish that are good for you, but arc in danger of being wiped out because of ovcrfishing. Sonic are being fished in the wild so much that they cannot reproduce enough to survive.Others re being farmed in ways that are not environmentally friendly. These fish include red snapper.Atlantic salmon, bluefnn tuna. and king crab. Despite these problems, there are several fish that are both healthy and sustainable , such as Alaskan salmon, American catfish, Pacific cod, and several fans-raised fish and shellfish.
Output: Which of the fish is safe for children according to the passage?
First, lets review plate tectonics theory. Plate tectonics theory explains why: Earths geography has changed over time and continues to change today. some places are prone to earthquakes while others are not. certain regions may have deadly, mild, or no volcanic eruptions. mountain ranges are located where they are. many ore deposits are located where they are. living and fossil species are found where they are. Plate tectonic motions affect Earths rock cycle, climate, and the evolution of life. Remember that Wegener used the similarity of the mountains on the west and east sides of the Atlantic as evidence for his continental drift hypothesis. Those mountains rose at the convergent plate boundaries where the continents were smashing together to create Pangaea. As Pangaea came together about 300 million years ago, the continents were separated by an ocean where the Atlantic is now. The proto-Atlantic ocean shrank as the Pacific Ocean grew. The Appalachian mountains of eastern North America formed at a convergent plate boundary as Pangaea came together (Figure 1.1). About 200 million years ago, the they were probably as high as the Himalayas, but they have been weathered and eroded significantly since the breakup of Pangaea. Pangaea has been breaking apart since about 250 million years ago. Divergent plate boundaries formed within the continents to cause them to rift apart. The continents are still moving apart, since the Pacific is shrinking as the Atlantic is growing. If the continents continue in their current directions, they will come together to create a supercontinent on the other side of the planet in around 200 million years. If you go back before Pangaea there were earlier supercontinents, such as Rodinia, which existed 750 million to 1.1 billion years ago, and Columbia, at 1.5 to 1.8 billion years ago. This supercontinent cycle is responsible for most of the geologic features that we see and many more that are long gone (Figure 1.2). Scientists think that the creation and breakup of a supercontinent takes place about every 500 million years. The supercontinent before Pangaea was Rodinia. A new continent will form as the Pacific ocean disappears. Click image to the left or use the URL below. URL:
Output: the name of the supercontinent that came together 300 million years ago.
Nox activator 1 (NoxA1) is a homologue of p67(phox) that acts in conjunction with Nox organizer 1 (NoxO1) to regulate reactive oxygen species (ROS) production by the NADPH oxidase Nox1. The phosphorylation of cytosolic regulatory components by multiple kinases plays important roles in assembly and activity of the phagocyte NADPH oxidase (Nox2) system, but little is known about regulation by phosphorylation in the Nox1 system. Here we identify Ser(172) and Ser(461) of NoxA1 as phosphorylation sites for protein kinase A (PKA). A consequence of this phosphorylation was the enhancement of NoxA1 complex formation with 14-3-3 proteins. Using both a transfected human embryonic kidney 293 cell Nox1 model system and endogenous Nox1 in colon cell lines, we showed that the elevation of cAMP inhibits, whereas the inhibition of PKA enhances, Nox1-dependent ROS production through effects on NoxA1. Inhibition of Nox1 activity was intensified by the availability of 14-3-3zeta protein, and this regulatory interaction was dependent on PKA-phosphorylatable sites at Ser(172) and Ser(461) in NoxA1. We showed that phosphorylation and 14-3-3 binding induce the dissociation of NoxA1 from the Nox1 complex at the plasma membrane, suggesting a mechanism for the inhibitory effect on Nox1 activity. Our data establish that PKA-phosphorylated NoxA1 is a new binding partner of 14-3-3 protein(s) and that this forms the basis of a novel mechanism regulating the formation of ROS by Nox1 and, potentially, other NoxA1-regulated Nox family members.
Output: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Polycomb gene silencing requires histone methyltransferase activity of Polycomb repressive complex 2 (PRC2), which methylates lysine 27 of histone H3. Information on how PRC2 works is limited by lack of structural data on the catalytic subunit, Enhancer of zeste (E(Z)), and the paucity of E(z) mutant alleles that alter its SET domain. Here we analyze missense alleles of Drosophila E(z), selected for molecular study because of their dominant genetic effects. Four missense alleles identify key E(Z) SET domain residues, and a fifth is located in the adjacent CXC domain. Analysis of mutant PRC2 complexes in vitro, and H3-K27 methylation in vivo, shows that each SET domain mutation disrupts PRC2 histone methyltransferase. Based on known SET domain structures, the mutations likely affect either the lysine-substrate binding pocket, the binding site for the adenosylmethionine methyl donor, or a critical tyrosine predicted to interact with the substrate lysine epsilon-amino group. In contrast, the CXC mutant retains catalytic activity, Lys-27 specificity, and trimethylation capacity. Deletion analysis also reveals a functional requirement for a conserved E(Z) domain N-terminal to CXC and SET. These results identify critical SET domain residues needed for PRC2 enzyme function, and they also emphasize functional inputs from outside the SET domain.
Output: What is the characteristic domain of histone methyltransferases?
Cap analysis of gene expression (CAGE) is a high-throughput method for transcriptome analysis that provides a single base-pair resolution map of transcription start sites (TSS) and their relative usage. Despite their high resolution and functional significance, published CAGE data are still underused in promoter analysis due to the absence of tools that enable its efficient manipulation and integration with other genome data types. Here we present CAGEr, an R implementation of novel methods for the analysis of differential TSS usage and promoter dynamics, integrated with CAGE data processing and promoterome mining into a first comprehensive CAGE toolbox on a common analysis platform. Crucially, we provide collections of TSSs derived from most published CAGE datasets, as well as direct access to FANTOM5 resource of TSSs for numerous human and mouse cell/tissue types from within R, greatly increasing the accessibility of precise context-specific TSS data for integrative analyses. The CAGEr package is freely available from Bioconductor at [Link]
Output: Which tool is used for promoterome mining using CAGE data?
In a house with more than one kid, there are bound to be some problems. Brothers and sisters borrow stuff, and don't always return it in top condition. Younger kids sometimes feel the older kids get to do whatever they want. Older brothers and sisters think that the baby of the family gets more attention. These are typical problems found throughout the ages, everywhere in the world. When brothers and sisters don't get along well, it's called sibling rivalry. A sibling is a brother or sister and rivalry means competition. It's normal, but too much competition can make for an unhappy home life. A little competition isn't a bad thing. Sometimes it can keep you working hard--when you and your brother spend time shooting hoops. If he's good at it, it may make you want to improve, too. But some sibling rivalry involves arguments--when you think your brother is hogging the ball. People who love each other might argue sometimes, but too much fighting is unpleasant for everyone. Have you ever heard of the green-eyed monster called jealousy ? Sometimes brothers and sisters are jealous of one another. For instance, if your sister always does well at school, it may be frustrating for you, especially if your grades are lower. Although you are probably proud of your brothers and sisters, it's normal to be a little jealous, too. It may make you feel better to focus more on doing your own personal things, rather than comparing yourself with a brother or sister. All kids want attention from their parents, but sometimes you need to take turns. It you are feeling ignored or your brother or sister is always in the spotlight, talk to your mom or dad. If a parent knows you're feeling left out, he or she can figure out ways to help you feel better again.
Output: What does the author think of a little jealousy between brothers and sisters?
EasyGroup Holdings Ltd (the investment vehicle of EasyJet founder Sir Stelios Haji-Ioannou and his family) is the largest shareholder with a 34.62% stake (as of July 2014).
Output: Who founded EasyJet?
Hartwall Arena is the home venue of the ice hockey team Jokerit.
Output: What team uses Hartwall Arena?
Used by over half a million learners,English Practice is one of the world's most popular online English learning products. English Practice offers over 40,000 interactive 1essons for all levels of students who want to study and improve their English. Our structured content will help you improve your speaking,vocabulary,grammar,and your listening and written comprehension. And because English Practice is online,you can study at a pace and at a time that is convenient for you. How to Study When you start with English Practice we will give you a test to evaluate your language level. We will then recommend that you start as either a beginning intermediate or advanced learner. At each level you can take classes in General English,Work Skills,or Community to improve the skills you need. When you have completed enough lessons,we will give you another test and move you up to the next level. General English This is where you will find lessons to improve your grammar,listening comprehension,and vocabulary. There are new lessons weekly so you will always find new 1essons to this area you can also take lessons to prepare for TOEFL and IELTS. Work Skills This is where you can take lessons to teach you the specific skills you will need if you have to speak English at work,or do business in English. There are lessons on general business skills as well as courses to on specific industries. Community In the Community section you find English Practice's popular chat room,where you can practice with fellow students from around the world,and ask English teachers questions about English Community also has fun games like Bingo,Hangman,and Karaoke. As well as links to online English studying resources.
Output: If you want to study English breezily ,you should get into the section.
Nusinersen (ISIS-SMNRx or ISIS 396443) is an antisense oligonucleotide drug administered intrathecally to treat spinal muscular atrophy. We summarize lumbar puncture experience in children with spinal muscular atrophy during a phase 1 open-label study of nusinersen and its extension. During the studies, 73 lumbar punctures were performed in 28 patients 2 to 14 years of age with type 2/3 spinal muscular atrophy. No complications occurred in 50 (68%) lumbar punctures; in 23 (32%) procedures, adverse events were attributed to lumbar puncture. Most common adverse events were headache (n = 9), back pain (n = 9), and post-lumbar puncture syndrome (n = 8). In a subgroup analysis, adverse events were more frequent in older children, children with type 3 spinal muscular atrophy, and with a 21- or 22-gauge needle compared to a 24-gauge needle or smaller. Lumbar punctures were successfully performed in children with spinal muscular atrophy; lumbar puncture-related adverse event frequency was similar to that previously reported in children.
Output: Which disease is treated with Nusinersen?
Johannes Scherg (16 May 1918 -- 22 December 1997) was a Hauptsturmfuhrer (Captain) in the Waffen SS during World War II who was awarded the Knight's Cross of the Iron Cross, which was awarded to recognize extreme battlefield bravery or successful military leadership by Nazi Germany during World War II. Johannes Scherg was born in Wurzburg on the 16 May 1918.
Output: What war did Johannes Scherg fight in?
Get Water! is a mobile game about the water scarcity in India and South Asia, and the effects it has on girls' education.
Output: Which place is Get Water! in?
Stress-induced mutagenesis describes the accumulation of mutations that occur in nongrowing cells, in contrast to mutagenesis that occurs in actively dividing populations, and has been referred to as stationary-phase or adaptive mutagenesis. The most widely studied system for stress-induced mutagenesis involves monitoring the appearance of Lac(+) revertants of the strain FC40 under starvation conditions in Escherichia coli. The SOS-inducible translesion DNA polymerase DinB plays an important role in this phenomenon. Loss of DinB (DNA pol IV) function results in a severe reduction of Lac(+) revertants. We previously reported that NusA, an essential component of elongating RNA polymerases, interacts with DinB. Here we report our unexpected observation that wild-type NusA function is required for stress-induced mutagenesis. We present evidence that this effect is unlikely to be due to defects in transcription of lac genes but rather is due to an inability to adapt and mutate in response to environmental stress. Furthermore, we extended our analysis to the formation of stress-induced mutants in response to antibiotic treatment, observing the same striking abolition of mutagenesis under entirely different conditions. Our results are the first to implicate NusA as a crucial participant in the phenomenon of stress-induced mutagenesis.
Output: In which phase of cell cycle does  stress-induced transcription-associated mutagenesis (TAM) occur?
Menpehtyre Ramesses I (traditional English: Ramesses or Ramses) was the founding pharaoh of ancient Egypt's 19th dynasty.
Output: What is the position of Ramesses I?
Diabolical Streak is the second studio album by American Neo-Cabaret artist Jill Tracy, released in 1999.
Output: What label was responsible for Diabolical Streak?
Gaius Julius Alexander Berenicianus (Greek: , about 75 -- about 150) was a Cilician Prince and second-born son to King Gaius Julius Alexander and Queen Julia Iotapa of Cetis.
Output: Which woman was the sister of Gaius Julius Alexander Berenicianus?
Gefitinib, the specific inhibitor of the epidermal growth factor receptor (EGFR), may cause growth delay in cancer cell lines. Thorough understanding of the downstream cellular signaling of gefitinib will facilitate the discovery of biomarkers for predicting outcomes and monitoring anti-EGFR therapies, and provide information for key targets for therapeutic intervention. In this study, we investigated the role of transducer of erbB2.1 (TOB1) in gefitinib therapy. Using the lung carcinoma cell lines A549 and NCI-H1975, the results suggested that gefitinib might mediate cell cycle arrest in lung cancer cells at least by targeting TOB1 expression. Gefitinib treatment caused cell cycle arrest predominantly at the G1 phase, which is associated with TOB1 nuclear translocation and its interaction with cyclin D1. We also showed that knockdown of TOB1 expression by RNAi rescued lung cancer cells from gefitinib-induced cell-proliferative arrest. These results suggest that TOB1 interaction with cyclin D1 and nuclear translocation is directly involved in the gefitinib-induced anti-proliferative cell cycle arrest.
Output: Which is the cellular target of gefitinib?
The human endoplasmic reticulum aminopeptidase (ERAP) 1 and 2 proteins were initially identified as homologues of human placental leucine aminopeptidase/insulin-regulated aminopeptidase. They are categorized as a unique class of proteases based on their subcellular localization on the luminal side of the endoplasmic reticulum. ERAPs play an important role in the N-terminal processing of the antigenic precursors that are presented on the major histocompatibility complex (MHC) class I molecules. ERAPs are also implicated in the regulation of a wide variety of physiological phenomena and pathogenic conditions. In this review, the current knowledge on ERAPs is summarized.
Output: Which is the  subcellular localization of ERAP2?
Selenoproteins are an elite group of proteins containing a rare amino acid, selenocysteine (Sec), encoded by the codon, UGA. In eukaryotes, incorporation of Sec requires a Sec insertion sequence (SECIS) element, a stem-loop structure located in the 3'-untranslated regions of selenoprotein mRNAs. Here we report identification of a noncanonical form of SECIS element in Toxoplasma gondii and Neospora canine, single-celled apicomplexan parasites of humans and domestic animals. This SECIS has a GGGA sequence in the SBP2-binding site in place of AUGA previously considered invariant. Using a combination of computational and molecular techniques, we show that Toxoplasma and Neospora possess both canonical and noncanonical SECIS elements. The GGGA-type SECIS element supported Sec insertion in mammalian HEK 293 and NIH 3T3 cells and did so more efficiently than the natural mammalian SECIS elements tested. In addition, mammalian type I and type II SECIS elements mutated into the GGGA forms were functional but manifested decreased Sec insertion efficiency. We carried out computational searches for both AUGA and GGGA forms of SECIS elements in Toxoplasma and detected five selenoprotein genes, including one coding for a previously undescribed selenoprotein, designated SelQ, and two containing the GGGA form of the SECIS element. In contrast, the GGGA-type SECIS elements were not detected in mammals and nematodes. As a practical outcome of the study, we developed pSelExpress1, a vector for convenient expression of selenoproteins in mammalian cells. It contains an SBP2 gene and the most efficient tested SECIS element: an AUGA mutant of the GGGA-type Toxoplasma SelT structure.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
We have recently shown that the Na(+)/Ca(2+) exchanger (NCX) is involved in nitric oxide (NO)-induced cytotoxicity in cultured astrocytes and neurons. However, there is no in vivo evidence suggesting the role of NCX in neurodegenerative disorders associated with NO. NO is implicated in the pathogenesis of neurodegenerative disorders such as Parkinson's disease. This study examined the effect of SEA0400, the specific NCX inhibitor, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity, a model of Parkinson's disease, in C57BL/6J mice. MPTP treatment (10 mg/kg, four times at 2-h intervals) decreased dopamine levels in the midbrain and impaired motor coordination, and these effects were counteracted by S-methylthiocitrulline, a selective neuronal NO synthase inhibitor. SEA0400 protected against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated mice. SEA0400 had no radical-scavenging activity. SEA0400 did not affect MPTP metabolism and MPTP-induced NO production and microglial activation, while it attenuated MPTP-induced increases in extracellular signal-regulated kinase (ERK) phosphorylation and lipid peroxidation product, thiobarbituric acid reactive substance. These findings suggest that SEA0400 protects against MPTP-induced neurotoxicity probably by blocking ERK phosphorylation and lipid peroxidation which are downstream of NCX-mediated Ca(2+) influx.
Output: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
Deep brain stimulation (DBS) is the technique of neurostimulation of deep brain structures for the treatment of conditions such as essential tremor, dystonia, Parkinson's disease and chronic pain syndromes. The procedure uses implanted deep brain stimulation electrodes connected to extension leads and an implantable pulse generator (IPG). Hardware failure related to the DBS procedure is not infrequent, and includes electrode migration and disconnection. We describe a patient who received bilateral globus pallidus internus DBS for dystonia with initially good clinical response, but the device eventually failed. Radiographs showed multiple twisting of the extension leads with disconnection from the brain electrodes and a diagnosis of Twiddler's syndrome was made. Twiddler's syndrome was first described in patients with cardiac pacemakers. Patients with mental disability, elderly and obese patients are at increased risk. Twiddler's syndrome should be suspected whenever there is a failure of the DBS device to relieve symptoms previously responsive to stimulation. Surgical correction is usually required.
Output: Neurostimulation of which nucleus is used for treatment of dystonia?
Abaete Linhas Aereas S/A is a domestic airline based in Lauro de Freitas, near Salvador da Bahia, Brazil founded in 1994.
Output: In what year did Abaeté Linhas Aéreas first exist?
This Is Jackie DeShannon is an LP album by Jackie DeShannon, released by Imperial Records under catalog number LP-9286 as a monophonic recording in 1965, and later in stereo under catalog number LP-12286 the same year.
Output: What label was responsible for This Is Jackie DeShannon?
In human colorectal carcinoma, RICTOR has been shown to association with FBXW7 (outside of mTORC2) to mediate the ubiquitination of growth-promoting factors cyclin E and c-Myc.
Output: Which species has the RICTOR gene?
Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor. We randomly assigned 450 patients with osteoarthritis of the knee to receive tanezumab (administered at a dose of 10, 25, 50, 100, or 200 g per kilogram of body weight) or placebo on days 1 and 56. The primary efficacy measures were knee pain while walking and the patient's global assessment of response to therapy. We also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT-OARSI); and safety. When averaged over weeks 1 through 16, the mean reductions from baseline in knee pain while walking ranged from 45 to 62% with various doses of tanezumab, as compared with 22% with placebo (P<0.001). Tanezumab, as compared with placebo, was also associated with significantly greater improvements in the response to therapy as assessed with the use of the patients' global assessment measure (mean increases in score of 29 to 47% with various doses of tanezumab, as compared with 19% with placebo; P0.001). The rate of response according to the OMERACT-OARSI criteria ranged from 74 to 93% with tanezumab treatment, as compared with 44% with placebo (P<0.001). The rates of adverse events were 68% and 55% in the tanezumab and placebo groups, respectively. The most common adverse events among tanezumab-treated patients were headache (9% of the patients), upper respiratory tract infection (7%), and paresthesia (7%). In this proof-of-concept study, treatment with tanezumab was associated with a reduction in joint pain and improvement in function, with mild and moderate adverse events, among patients with moderate-to-severe osteoarthritis of the knee. (Funded by Rinat Neuroscience; ClinicalTrials.gov number, NCT00394563.).
Output: What is the target of tanezumab?
She was interred as Theda Bara Brabin in Forest Lawn Memorial Park Cemetery in Glendale, California.
Output: At what cemetery is Theda Bara buried?
I wish there would be a way to describe China in simple terms but that's impossible. For the most part Chinese people are friendly, easy-going and optimistic. They are curious and unusually patient and they are also the hardest-working people I have ever met. In China, family is everything. In my English classes when the students were asked what they would do if they only had a few hours to live, most students told me how they would spend their last few hours with their families and parents. Many times the subjects in the classes center on families and friends. I teach many students a year, talking to them freely. The cost of living here is very low compared with that of the US. The city of Xiang Fan I live in isn't large and I live better. Non-imported foods are very cheap, so are clothing and articles of everyday use. The cost of public transportation is very low, too. Chinese value education. However, it is reported that many children can't afford the expenses of schooling and are forced to leave school in some poor area in China. But they organized Project Hope many years age. It creates conditions for the poor children to go back to school. In my opinion, Project Hope is of great importance to the development of the rural education. When we read news of China in the west, rarely, if ever, will we see anything mentioned of the positive changes China has gone through. While it is true that economic miracles have not reached many areas of China, but we also have the same problems. When I am asked which country I consider better. China or the US, my answer has always been the same, "We are not worse or better than each other, we are only different."
Output: What are not cheap in China in the author's opinion?
Jan Muhlstein (born 3 July 1949 in Most, Czechoslovakia) is a journalist, German Jewish activist and the former chair of the Union of Progressive Jews in Germany.
Output: Which language or languages is Jan Mühlstein fluent in?
Christianson syndrome (CS) is caused by mutations in SLC9A6 and is characterized by severe intellectual disability, absent speech, microcephaly, ataxia, seizures, and behavioral abnormalities. The clinical phenotypes of CS and Angelman syndrome (AS) are similar. Differentiation between CS and AS is important in terms of genetic counseling. We report on two children with CS and confirmed mutations in SLC9A6 focusing on neuroimaging findings and review the available literature. Cerebellar atrophy (CA) occurs in approximately 60% of the patients with CS and develops after the age of 12 months. Hyperintense signal of the cerebellar cortex (CbC) is less common, and may be diffuse, patchy, or involve only the inferior part of the cerebellum and is best seen on coronal fluid attenuation inversion recovery images. CA and CbC-hyperintensity are not neuroimaging features of AS. In a child with the phenotype of AS, CA and/or CbC-hyperintensity are rather specific for CS and should prioritize sequencing of SLC9A6.
Output: Mutation of which gene is implicated in the Christianson syndrome?
Huruma Estate is a residential estate located in the northeast of Nairobi, the capital of Kenya.
Output: What country is home to Huruma?