niryuu/sni-each-converted huggingface dataset:
When I was a baby, I entertained you and made you laugh.Whenever I was "bad", you'd shake your finger at me and ask, "How could you?"--but then you'd give up, and roll me over for a belly scratch and I believed that life could not be any more perfect. My housetraining was a long process, because you were terribly busy, but we worked on that together. We went for long walks, runs in the park and car rides. We stopped for ice cream. I took long naps in the sun waiting for you to come home at the end of the day. Gradually, you began spending more time at work and on your career, and more time searching for a human mate.Eventually, you fell in love.She, now your wife, is not a dog person, but I still welcomed her into our home.I was happy because you were happy.Then the human babies came along and I shared your excitement, I was fascinated by their pinkness, how they smelled, and I wanted to mother them too. Your wife was afraid I would bite them.But nevertheless, as they began to grow, I became their friend.Now, you have a new job in another city and you and they will be moving to an apartment that does not allow pets.You've made the right decision for your "family", but there was a time when I was your only family. I was excited about the car ride until we arrived at the dog pound.It smelled of dogs and cats, of fear, of hopelessness.You filled out the paperwork and said, "I know you will find a good home for her".They shrugged and gave you a pained look.The children were in tears as they waved me goodbye.And "How could you?" were the only three words that swept over my mind. Is it better to live with hope or without hope? At first, whenever anyone passed my pen , I rushed to the front, hoping it was you, that you had changed your mind and that this was all a bad dream. My beloved master, I will think of you and wait for you forever.I hope you receive more faithfulness from your family than you showed to me.
Output: Who tells this story?
The 6000-mark war was a war between Denmark and Sweden which took place from 1276 to 1278. It started because of a disagreement over an agreed sum of 6,000 silver marks for Danish assistance to Magnus Birgersson in the battle against Valdemar Birgersson in 1275.
Output: What was Magnus Birgersson supposed to have been paid for?
The layers scientists recognize are pictured below (Figure 1.1). Core, mantle, and crust are divisions based on composition: 1. The crust is less than 1% of Earth by mass. The two types are oceanic crust and continental crust.Continental crust is felsic and oceanic crust is mafic. 2. The mantle is hot, ultramafic rock. It represents about 68% of Earths mass. 3. The core is mostly iron metal. The core makes up about 31% of the Earth. Lithosphere and asthenosphere are divisions based on mechanical properties: 1. The lithosphere is composed of both the crust and the portion of the upper mantle and behaves as a brittle, rigid solid. 2. The asthenosphere is partially molten upper mantle material and behaves plastically and can flow. A cross section of Earth showing the fol- lowing layers: (1) crust (2) mantle (3a) outer core (3b) inner core (4) lithosphere (5) asthenosphere (6) outer core (7) inner core. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:
Output: this layer is made up of both crust and uppermost mantle.
The Swc4p protein, encoded by an essential gene, is shared by two chromatin-remodeling complexes in Saccharomyces cerevisiae cells: NuA4 (nucleosome acetyltransferase of H4) and SWR1. The SWR1 complex catalyzes ATP-dependent exchange of the nucleosomal histone H2A for H2AZ (Htz1p). The activity of NuA4 is responsible mainly for the acetylation of the H4 histone but also for the acetylation of H2A and H2AZ. In this work we investigated the role of the Swc4p protein. Using random mutagenesis we isolated a collection of swc4 mutants and showed that the essential function of Swc4p resides in its N-terminal part, within the first 269 amino acids of the 476-amino acid-long protein. We also demonstrated that Swc4p is able to accommodate numerous mutations without losing its functionality under standard growth conditions. However, when swc4 mutants were exposed to methyl methanesulfonate (MMS), hydroxyurea or benomyl, severe growth deficiencies appeared, pointing to an involvement of Swc4p in many chromatin-based processes. The mutants' phenotypes did not result from an impairment of histone acetylation, as in the mutant which bears the shortest isolated variant of truncated Swc4p, the level of overall H4 acetylation was unchanged.
Output: Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
Tortillitas de camarones are shrimp fritters from the province of Cadiz in Andalusia, Spain.
Output: The country for Tortillitas de camarones was what?
The most obvious landforms created by lava are volcanoes, most commonly as cinder cones, composite volcanoes, and shield volcanoes. Eruptions also take place through other types of vents, commonly from fissures (Figure 1.1). The eruptions that created the entire ocean floor are essentially fissure eruptions. Viscous lava flows slowly. If there is not enough magma or enough pressure to create an explosive eruption, the magma may form a lava dome. Because it is so thick, the lava does not flow far from the vent. (Figure 1.2). Lava flows often make mounds right in the middle of craters at the top of volcanoes, as seen in the Figure 1.3. A fissure eruption on Mauna Loa in Hawaii travels toward Mauna Kea on the Big Is- land. Lava domes are large, round landforms created by thick lava that does not travel far from the vent. Lava domes may form in the crater of composite volcanoes as at Mount St. He- lens. A lava plateau forms when large amounts of fluid lava flow over an extensive area (Figure 1.4). When the lava solidifies, it creates a large, flat surface of igneous rock. Layer upon layer of basalt have created the Columbia Plateau, which covers more than 161,000 square kilometers (63,000 square miles) in Washington, Oregon, and Idaho. Lava creates new land as it solidifies on the coast or emerges from beneath the water (Figure 1.5). Lava flowing into the sea creates new land in Hawaii. Over time the eruptions can create whole islands. The Hawaiian Islands are formed from shield volcano eruptions that have grown over the last 5 million years (Figure 1.6). The island of Hawaii was created by hotspot volcanism. You can see some of the volcanoes (both active and extinct) in this mosaic of false-color composite satellite images. Magma intrusions can create landforms. Shiprock in New Mexico is the neck of an old volcano that has eroded away (Figure 1.7). The volcanic neck is the remnant of the conduit the magma traveled up to feed an eruption. The aptly named Shiprock in New Mexico.
Output: shiprock in new mexico is this type of landform.
Alice de Toeni, Countess of Warwick (26 April 1284 -- 1 January 1324/25) was a wealthy English heiress and the second wife of Guy de Beauchamp, 10th Earl of Warwick (1272 -- 12 August 1315), an English nobleman in the reign of Kings Edward I and Edward II. He was one of the principal opponents of Piers Gaveston, a favourite of Edward II. Alice married three times;
Output: What is Alice de Toeni, Countess of Warwick's spouse's name?
Fergus Crane is a children's book written by Paul Stewart and illustrated by Chris Riddell, published in 2004.
Output: Who was Fergus Crane illustrated by?
Val Abbey (Abbey of St Mary of Val) (Abbaye Notre-Dame du Val) was a Cistercian abbey in Meriel and Villiers-Adam in Val-d'Oise, 30 kilometers north of Paris.
Output: To which religious order did Val Abbey belong?
Arik Air's head office is the Arik Air Aviation Center on the grounds of Murtala Muhammed International Airport in Ikeja, Lagos State.
Output: What is the name of the airport where Arik Air is located?
Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in adults. Classical ALS is characterized by the death of upper and lower motor neurons leading to progressive paralysis. Approximately 10% of ALS patients have familial form of the disease. Numerous different gene mutations have been found in familial cases of ALS, such as mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), C9ORF72, ubiquilin-2 (UBQLN2), optineurin (OPTN) and others. Multiple animal models were generated to mimic the disease and to test future treatments. However, no animal model fully replicates the spectrum of phenotypes in the human disease and it is difficult to assess how a therapeutic effect in disease models can predict efficacy in humans. Importantly, the genetic and phenotypic heterogeneity of ALS leads to a variety of responses to similar treatment regimens. From this has emerged the concept of personalized medicine (PM), which is a medical scheme that combines study of genetic, environmental and clinical diagnostic testing, including biomarkers, to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and similarities between animal models of disease and human disease. Finally, we reviewed application of biomarkers and gene therapies relevant in personalized medicine approach. For instance, this includes viral delivering of antisense oligonucleotide and small interfering RNA in SOD1, TDP-43 and C9orf72 mice models. Promising gene therapies raised possibilities for treating differently the major mutations in familial ALS cases.
Output: Which human disease is associated with mutated UBQLN2
On 15 December 2015, Chanzeaux, La Chapelle-Rousselin, Chemille-Melay, Cosse-d'Anjou, La Jumelliere, Neuvy-en-Mauges, Sainte-Christine, Saint-Georges-des-Gardes, Saint-Lezin, La Salle-de-Vihiers, La Tourlandry and Valanjou merged becoming one commune called Chemille-en-Anjou.
Output: What was replaced Saint-Georges-des-Gardes?
The Mahlow station was opened along with the Dresden Railway on 17 June 1875.
Output: What was the date of the opening of Mahlow station?
Some minerals are very useful. An ore is a rock that contains minerals with useful elements. Aluminum in bauxite ore (Figure 1.1) is extracted from the ground and refined to be used in aluminum foil and many other products. The cost of creating a product from a mineral depends on how abundant the mineral is and how much the extraction and refining processes cost. Environmental damage from these processes is often not figured into a products cost. It is important to use mineral resources wisely. Geologic processes create and concentrate minerals that are valuable natural resources. Geologists study geological formations and then test the physical and chemical properties of soil and rocks to locate possible ores and determine their size and concentration. A mineral deposit will only be mined if it is profitable. A concentration of minerals is only called an ore deposit if it is profitable to mine. There are many ways to mine ores. Aluminum is made from the aluminum- bearing minerals in bauxite. Surface mining allows extraction of ores that are close to Earths surface. Overlying rock is blasted and the rock that contains the valuable minerals is placed in a truck and taken to a refinery. As pictured in Figure 1.2, surface mining includes open-pit mining and mountaintop removal. Other methods of surface mining include strip mining, placer mining, and dredging. Strip mining is like open pit mining but with material removed along a strip. These different forms of surface mining are methods of extracting ores close to Earths surface. Placers are valuable minerals found in stream gravels. Californias nickname, the Golden State, can be traced back to the discovery of placer deposits of gold in 1848. The gold weathered out of hard metamorphic rock in the western Sierra Nevada, which also contains deposits of copper, lead, zinc, silver, chromite, and other valuable minerals. The Underground mining is used to recover ores that are deeper into Earths surface. Miners blast and tunnel into rock to gain access to the ores. How underground mining is approached from above, below, or sideways depends on the placement of the ore body, its depth, the concentration of ore, and the strength of the surrounding rock. Underground mining is very expensive and dangerous. Fresh air and lights must also be brought into the tunnels for the miners, and accidents are far too common. The ores journey to becoming a useable material is only just beginning when the ore leaves the mine (Figure separated out of the ore. A few methods for extracting ore are: heap leaching: the addition of chemicals, such as cyanide or acid, to remove ore. flotation: the addition of a compound that attaches to the valuable mineral and floats. smelting: roasting rock, causing it to segregate into layers so the mineral can be extracted. To extract the metal from the ore, the rock is melted at a temperature greater than 900o C, which requires a lot of energy. Extracting metal from rock is so energy-intensive that if you recycle just 40 aluminum cans, you will save the energy equivalent of one gallon of gasoline.
Output: when valuable minerals are taken from stream gravels, this is called
Sulfonylureas (SUs) are commonly used in the treatment of type 2 diabetes (T2DM), usually as second-line treatment after the failure of metformin. However, SUs are associated with poor durability, hypoglycemia and weight gain. Empagliflozin is a sodium glucose cotransporter 2 (SGLT2) inhibitor in development for the treatment of T2DM. In Phase II/III trials, empagliflozin reduced hyperglycemia, body weight and blood pressure, with a low incidence of hypoglycemia. The aim of this Phase III study is to compare the effects of empagliflozin and the SU glimepiride as second-line therapy in patients with T2DM inadequately controlled with metformin immediate release (IR) and diet/exercise. After a 2-week placebo run-in, patients were randomized to receive empagliflozin 25 mg once daily (qd) or glimepiride 1-4 mg qd double-blind for 2 years, in addition to metformin IR. Patients who participate in the initial 2-year randomization period will be eligible for a 2-year double-blind extension. The primary endpoint is change from baseline in HbA1c. Secondary endpoints are change from baseline in body weight, the incidence of confirmed hypoglycemia and changes in systolic and diastolic blood pressure. Exploratory endpoints include markers of insulin secretion, body composition and responder analyses. Safety endpoints include the incidence of adverse events (AEs) (including macro- and microvascular adverse events) and changes from baseline in clinical laboratory parameters. Between August 2010 and June 2011, 1549 patients were randomized and 1545 patients were treated. At baseline, mean (SD) age was 55.9 (10.4) years, HbA1c was 7.92 (0.84)%, body mass index was 30.11 (5.59) kg/m, systolic blood pressure was 133.5 (15.9) mmHg and diastolic blood pressure was 79.5 (9.4) mmHg. This is the largest study to compare the efficacy and safety of an SGLT2 inhibitor with an SU in patients with T2DM inadequately controlled on metformin to date. In addition to determining the effects of these treatments on glycemic control over the long term, this study will investigate effects on beta-cell function, cardiovascular risk factors and markers of renal function/damage. The results will help to inform the choice of second-line treatment in patients with T2DM who have failed on metformin. Clinicaltrials.gov NCT01167881.
Output: Which protein does empagliflozin inhibit?
Advances in Adaptive Data Analysis (AADA) is an interdisciplinary scientific journal published by World Scientific.
Output: Who published Advances in Adaptive Data Analysis?
Maxime Bono (born 1 November 1947 in Algiers, Algeria) is a French politician and a member of the Socialist party.
Output: What city was Maxime Bono born?
Richard Donnevert (born 2 August 1896 in Mainz - died 27 January 1970 in Wiesbaden) was a German Nazi Party politician.
Output: What was the political party of Richard Donnevert?
His Girl Friday is a 1940 American screwball comedy film directed by Howard Hawks, from an adaptation by Charles Lederer, Ben Hecht and Charles MacArthur of the play The Front Page by Hecht and MacArthur.
Output: The His Girl Friday is based upon what?
The Introduction and Rondo Capriccioso in A minor (French: Introduction et Rondo capriccioso en la mineur ), Op. 28, is a composition for violin and orchestra written in 1863 by Camille Saint-Saens for the virtuoso violinist Pablo de Sarasate.
Output: On which instrument(s) was Introduction and Rondo Capriccioso created to be played on?
Cleopatra and Antony staged both ''Donations'' to donate lands dominated by Rome and Parthia to Cleopatra's children: the 11-year-old Caesarion (fathered by Julius Caesar) and the 4 year old twins Alexander Helios and Cleopatra Selene II (fathered by Marc Antony) initially in 36 BC, and in 34 BC including the 2 year old Ptolemy Philadelphus.
Output: Who is Caesarion's sister?
Once upon a time there was a crook who only thought about how to get money. What he hated most was when people were polite to each other, saying things like "please", "thank you", and "don't mention it". The crook thought all those kinds of words were a waste, so he spent a lot of time inventing a machine which could steal words. With this machine, he planned to steal "please", "thank you", "don't mention it", and similar words people used to be polite. After he stole these words, he intended to take them apart and sell the letters to book publishers. After he started up his machine, people would open their mouths, intending to say kind and polite things, but nothing came out. All those words ended up inside the big machine. The crook was happy with his success, but he didn't count on a couple of very special little girls. Those girls were deaf, and had to communicate with sign language. Because the machine couldn't steal gestures, these girls continued being kind and polite. Soon they realized what had been happening to everyone else, and they found out about the crook and his plan. The girls followed him and found the machine busy separating all the words into letters. They approached the machine and started being polite to each other. Try as it might, the machine couldn't steal those words, and it started to suffer a power overload . Finally, it exploded, sending all the letters it had gathered flying into the sky. These letters started coming down, like rain, and most ended up in the sea. After that, everyone could be polite again. Seeing all those letters fall into the sea, those little girls had an idea. A little while later they opened a factory, making alphabetic spaghetti soup!
Output: Why did the machine have no effect on the two girls?
Alphonse Milne-Edwards (Paris, 13 October 1835 -- Paris, 21 April 1900) was a French mammalologist, ornithologist and carcinologist.
Output: Where did Alphonse Milne-Edwards live when he died?
The vast majority of fitness trackers count your steps and are worn around the wrist, but now there's a device that's designed to be worn like a necklace and monitors tiny movements to improve your posture. The Fineck device aims to address neck pain by tracking tiny movement, spotting bad habits and suggesting exercises via an accompanying app. Made from silicone and titanium , Fineck monitors a wearer's movement, balance, posture and movement thanks to sensors inside. The Mountain View California-based firm says that a high percentage of people suffer from neck pain and associated problems, probably caused by more individuals doing office jobs, which generally involve leaning over computer keyboard. The device contains sensors, several different types of instruments to monitor movement, plus a monitor to shake. It connects to an IOS app via Bluetooth so that wearers can see their bad habits and play "neck training" games. The app warns of health risks and records a user's activity to build up a customer personal health description. The necklace shakes to give smart advice, such as reminding wearers to sit up straight. The app also allows users to set goals, like many other wearables do. "Fineck is the first wearable device for your neck that tracks your neck activity and warn you when you are in a bad posture for too long. You can also exercise your neck with Fineck's interactive games." The company writes on Kickstarter. "No matter where you are and what you are doing at office, on the go, or simply just feeling bored, Fineck will bring you enriched exercise experience through motion sensing games and therapies." It also claims that it is "the world's first titanium wearable device". The metal is widely used in fashion stuff that you can wear or carry to match your clothes because it is lightweight, durable and does not tend to cause allergic reactions. It also offers additional features such as shaking to indicate alerts on a user's smartphone, but it is not currently clear whether it can also be used like bands, to count steps, and so on. The Fineck has a battery life of around seven days and takes one hour to charge. It is available to pre-order via Kickstarter from $69(PS44)and is due to ship in March next year.
Output: What helps the Fineck device to deal with neck pain?
Aava Whistler Hotel Star Ratings: Location: Whistler Rooms:192 Stay at the Aava Whistler Hotel (formerly Coast Whistler Hotel) and experience a great vacation. The Aava Whistler Hotel is within minutes from over a hundred shopping malls and restaurants. It also has a great number of recreational facilities, including swimming, diving and even skiing. Hotel services include 24-hour reception, laundry and room service. Guests can stay in cozy rooms equipped with air-conditioning, bathroom and television. From CNY=496 per night. Best Western Cairn Croft Hotel Star Ratings: Location: East Lundy's Lane Room:l66 Relax and unwind at the Best Western Cairn Hotel. This resort-style hotel is located just minutes from the airport. At the Best Western Cairn Croft, guests can enjoy a large number of recreational facilities, including children's activities, sightseeing and a swimming pool. Business travelers can also take advantage of spacious meeting and banqueting facilities for hosting corporate events. All rooms come with basic amenities . From CNY=439 per night. Clarion Hotel&Suites Downtown Montreal Star Ratings: Location:Montreal Rooms:266 Conveniently located just 20 minutes from the airport, the Clarion Hotel&Suite Downtown Montreal is a moderately-priced three-star hotel that provides services to both business and leisure travelers. The Clarion has spacious meeting facilities and modern business centers for business travelers. It also has a sauna and whirlpool where guest can relax. All rooms come with basic amenities, including cable TV and a kitchenette. From CNY=553 per night. Delta Bow Valley Hotel Star Ratings: Location:Calgary Rooms:398 The Delta Bow Valley Hotel is located a couple of blocks north of Olympic Plaza, east of James Short Park, and north-east of the Petro-Canada Centre. Apart from business and recreational services such as a business centre, fitness centre and restaurant, all rooms in the Delta come with a mini-bar and in-house movies. From CNY=l, 227 per night.
Output: Which hotel offers facilities for children's activities?
Why is pink or purple a color for girls and blue or brown for boys? The answer depends largely on cultural values as well as personal experiences. To the Egyptians, green was a color that represented the hope and joy of spring, while for Muslims, it means heaven. Red is a symbol of good luck in many cultures. In China, children are given money in a red envelope to bring good fortune in the New Year. For many nations, blue is a symbol of protection and religious beliefs. Greek people often wear a blue necklace hoping to protect themselves against evils . People's choice of colors is also influenced by their bodies' reactions toward them. Green is said to be the most restful color. It has the ability to reduce pain and relax people both mentally and physically. People who work in green environment have been found to have fewer stomach aches. Red can cause a person's blood pressure to rise and increase people's appetites . Many decorators will include different shades of red in the restaurant. Similarly, many commercial websites will have a red "Buy Now" button because red is a color that easily catches a person's eye. Blue is another calming color. Unlike red, blue can cause people to lose appetite. So if you want to eat less, some suggest that eating from blue plates can help. The next time you are deciding on what to wear or what color to decorate your room, think about the color carefully.
Output: What color might help lose weight according to the text?
Most people agree that eating healthy food is important. But sometimes making good food choices can be difficult. Now, there are apps that can help people learn about the food they eat to improve their health and their dining out experience. OpenTable app OpenTable app helps people choose restaurants when they want to go out to eat. It is a free service that shows users restaurant available based on where and when they want to dine. It gives users points when they make reservations, which can add up to discounts on restaurant visits. Max McCalman's Cheese & Wine Pairing app Wine and cheese can be a great combination. But which wines go best with which cheeses? Max McCalman's Cheese & Wine Pairing app can help. It provides information about hundreds of different cheeses and suggests wines to pair with each. Max McCalman's Cheese & Wine Pairing app is free. HappyCow app Vegetarians do not eat animal meat. Vegans do not eat any animal products. The HappyCow app is made for both groups. Users can search for vegetarian-vegan restaurants and stores around the world. LocalEats app Restaurant chains, like McDonalds, can be found almost anywhere a person might travel. But sometimes travelers want to eat like locals. The LocalEats app is designed for that. It can help you find local restaurants in major cities in the US. and in other countries. It costs about a dollar. WhereChefsEat app Where Chefs Eat is a 975-page book. Most people would not want to carry that around. But there is a much lighter app version of the same name for just $15. Six hundred chefs provide information on 3,000 restaurants around the world on the WhereChefsEat app.
Output: What app costs you most according to the text?
Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene.
Output: What species is Interleukin 13 receptor, alpha 1 specific to?
118401 LINEAR (provisional designation 1999 RE70) is an asteroid and main-belt comet (176P/LINEAR) that was discovered by the Lincoln Near-Earth Asteroid Research (LINEAR) 1-metre telescopes in Socorro, New Mexico on September 7, 1999.
Output: Who made 118401 LINEAR known?
Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We evaluated secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis. In two phase 3, double-blind, 52-week trials, ERASURE (Efficacy of Response and Safety of Two Fixed Secukinumab Regimens in Psoriasis) and FIXTURE (Full Year Investigative Examination of Secukinumab vs. Etanercept Using Two Dosing Regimens to Determine Efficacy in Psoriasis), we randomly assigned 738 patients (in the ERASURE study) and 1306 patients (in the FIXTURE study) to subcutaneous secukinumab at a dose of 300 mg or 150 mg (administered once weekly for 5 weeks, then every 4 weeks), placebo, or (in the FIXTURE study only) etanercept at a dose of 50 mg (administered twice weekly for 12 weeks, then once weekly). The objective of each study was to show the superiority of secukinumab over placebo at week 12 with respect to the proportion of patients who had a reduction of 75% or more from baseline in the psoriasis area-and-severity index score (PASI 75) and a score of 0 (clear) or 1 (almost clear) on a 5-point modified investigator's global assessment (coprimary end points). The proportion of patients who met the criterion for PASI 75 at week 12 was higher with each secukinumab dose than with placebo or etanercept: in the ERASURE study, the rates were 81.6% with 300 mg of secukinumab, 71.6% with 150 mg of secukinumab, and 4.5% with placebo; in the FIXTURE study, the rates were 77.1% with 300 mg of secukinumab, 67.0% with 150 mg of secukinumab, 44.0% with etanercept, and 4.9% with placebo (P<0.001 for each secukinumab dose vs. comparators). The proportion of patients with a response of 0 or 1 on the modified investigator's global assessment at week 12 was higher with each secukinumab dose than with placebo or etanercept: in the ERASURE study, the rates were 65.3% with 300 mg of secukinumab, 51.2% with 150 mg of secukinumab, and 2.4% with placebo; in the FIXTURE study, the rates were 62.5% with 300 mg of secukinumab, 51.1% with 150 mg of secukinumab, 27.2% with etanercept, and 2.8% with placebo (P<0.001 for each secukinumab dose vs. comparators). The rates of infection were higher with secukinumab than with placebo in both studies and were similar to those with etanercept. Secukinumab was effective for psoriasis in two randomized trials, validating interleukin-17A as a therapeutic target. (Funded by Novartis Pharmaceuticals; ERASURE and FIXTURE ClinicalTrials.gov numbers, NCT01365455 and NCT01358578, respectively.).
Output: Which molecule is targeted by a monoclonal antibody Secukinumab?
Nations that have more industry produce more hazardous waste. Currently, the United States is the worlds largest producer of hazardous wastes, but China, which produces so many products for the developed world, may soon take over the number-one spot. Countries with more industry produce more hazardous wastes than those with little industry. Problems with haz- ardous wastes and their disposal became obvious sooner in the developed world than in the developing world. As a result, many developed nations, including the United States, have laws to help control hazardous waste disposal and to clean toxic sites. As mentioned in the "Impacts of Hazardous Waste" concept, the Superfund Act requires companies to clean up contaminated sites that are designated as Superfund sites (Figure 1.1). If a responsible party cannot be identified, because the company has gone out of business or its culpability cannot be proven, the federal government pays for the cleanup out of a trust fund with money put aside by the petroleum and chemical industries. As a result of the Superfund Act, companies today are more careful about how they deal with hazardous substances. Superfund sites are located all over the nation and many are waiting to be cleaned up. The Resource Conservation and Recovery Act of 1976 requires that companies keep track of any hazardous materials they produce. These materials must be disposed of using government guidelines and records must be kept to show the government that the wastes were disposed of safely. Workers must be protected from the hazardous materials. To some extent, individuals can control the production and disposal of hazardous wastes. We can choose to use materials that are not hazardous, such as using vinegar as a cleanser. At home, people can control the amount of pesticides that they use (or they can use organic methods of pest control). It is also necessary to dispose of hazardous materials properly by not pouring them over the land, down the drain or toilet, or into a sewer or trashcan. Click image to the left or use the URL below. URL:
Output: this country is currently the largest producer of hazardous waste.
After Atahualpa's execution, Pizarro installed Atahualpa's brother, Tupac Huallpa, as a puppet Inca ruler, but he soon died unexpectedly, leaving Manco Inca Yupanqui in power. He began his rule as an ally of the Spanish and was respected in the southern regions of the empire, but there was still much unrest in the north near Quito where Atahualpa's generals were amassing troops. Atahualpa's death meant that there was no hostage left to deter these northern armies from attacking the invaders. Led by Atahualpa's generals Ruminahui, Zope-Zupahua and Quisquis, the native armies were finally defeated, effectively ending any organized rebellion in the north of the empire.:221-223,226 Archaeological evidence of the rebellion incident exists. The remains of about 70 men, women, and adolescents were found in the path of a planned expressway near Lima in 2007. Forensic evidence suggests that the natives were killed by European weapons, probably during the uprising in 1536. Manco Inca initially had good relations with Francisco Pizarro and several other Spanish conquistadors. However, in 1535 he was left in Cuzco under the control of Pizarro's brothers, Juan and Gonzalo, who so mistreated Manco Inca that he ultimately rebelled. Under the pretense of recovering a statue of pure gold in the nearby Yucay valley, Manco was able to escape Cuzco.:235-237
Output: Who did Tupac Huallpa succeed as Inca ruler?
The authors reported a 73-year-old alcoholic man with previously-unrecognized situs inversus totalis suffering from left upper quadrant pain. Acute myocardial infarction was diagnosed and coronary angioplasty was performed immediately. However, the massive bleeding from the previously-unfound hepatomas caused hypovolemic shock and fatal outcome. Situs inversus totalis is a rare congenital anomaly with a complete mirror image of the thoracic and abdominal organs. Although being considered a benign entity, it would disturb diagnosis-making of the visceral diseases owing to the altered anatomy. To our knowledge, the coexistence of the coronary artery disease and ruptured hepatomas in situs inversus totalis, as in our patient, is never described. Recognition of any situs anomalies in time is the key to avoid misdiagnosis, inappropriate managements, and unwanted consequences.
Output: What is situs inversus?
Loss of consciousness in childhood may be due to cardiovascular causes, and the Long Q-T syndromes can present with seizures. The Romano-Ward syndrome is of autosomal dominant inheritance, and the Jervell and Lange-Nielson syndrome, with associated deafness, of autosomal recessive inheritance. The diagnosis is often delayed, but a careful history can avoid this. The syndromes can appear to be due to an imbalance in the sympathetic nerve to the ventricular myocardium, and precipitating causes such as stress suggest a CNS influence on this. The electrocardiogram can confirm the prolonged Q-T interval, but this is not always present, at least without an exercise test. Treatment with beta-blockers is often successful. If a wrong diagnosis of epilepsy is made a chance may be missed of avoiding sudden death, quite apart from all the medical, and social consequences that can result from such a diagnosis.
Output: What is the mode of inheritance of Romano Ward long QT syndrome?
Antonio Codronchi (5 August 1746, Imola - 22 January 1826, Ravenna) was an Italian priest and archbishop.
Output: Which position was held by Antonio Codronchi?
1. Using SEA0400, a potent and selective inhibitor of the Na+-Ca2+ exchanger (NCX), we examined whether NCX is involved in nitric oxide (NO)-induced disturbance of endoplasmic reticulum (ER) Ca2+ homeostasis followed by apoptosis in cultured rat microglia. 2. Sodium nitroprusside (SNP), an NO donor, decreased cell viability in a dose- and time-dependent manner with apoptotic cell death in cultured microglia. 3. Treatment with SNP decreased the ER Ca2+ levels as evaluated by measuring the increase in cytosolic Ca2+ level induced by exposing cells to thapsigargin, an irreversible inhibitor of ER Ca2+-ATPase. 4. The treatment with SNP also increased mRNA expression of CHOP and GPR78, makers of ER stress. 5. SEA0400 at 0.3-1.0 microM protected microglia against SNP-induced apoptosis. 6. SEA0400 blocked not only the SNP-induced decrease in ER Ca2+ levels but also SNP-induced increase in CHOP and GRP78 mRNAs. 7. SEA0400 did not affect capacitative Ca2+ entry in the presence and absence of SNP. 8. SNP increased Na+-dependent 45Ca2+ uptake and this increase was blocked by SEA0400. 9. These results suggest that SNP induces apoptosis via the ER stress pathway and SEA0400 attenuates SNP-induced apoptosis via suppression of the ER stress in cultured microglia. Our findings imply that NCX plays a role in ER Ca2+ depletion under pathological conditions.
Output: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
The film explores adolescent issues through the minds of three friends and their reactions after a boy named Rudy Carges (Conor Donovan) is killed in a tree house set on fire by local bullies Jeff and Kenny, who carelessly didn't find out he was inside until too late. The boy's twin brother Jacob, a boy with a huge birthmark (also played by Donovan), decides to seek revenge against the bullies. Leonard (Jesse Camacho) who's overweight, survives the tree house fire but loses his sense of taste and smell. Thanks to the fire, this prompts Leonard to go on a diet, which isn't welcomed by his obese family. The boys' female friend Malee (Zoe Weizenbaum) tries to befriend an adult named Gus (Jeremy Renner), a grief-stricken patient of her therapist mother, Carla (Annabella Sciorra). Jacob's family falls apart after the death of his brother. But shortly after, his parents adopt a boy named Keith Gardner. Meanwhile, Malee begins to have a crush on Gus and changes the song for her recital to one Gus liked, just for him. As time goes by, she sees Gus as her "soul mate". She sneaks into his house one night to find him grieving. Afraid to confront him, Malee steals his gun and leaves. She gives it to Jacob the following day. Jacob frequently visits Jeff and Kenny, who are serving time in a juvenile hall. Jacob initially threatens them, until eventually Jeff commits suicide. Jacob befriends Kenny, soon learning he has an early release and is illegally moving to New Mexico. Meanwhile, Leonard's father decides to take his sisters to Florida instead of Leonard (who would usually go). Leonard decides to force his mother to lose weight by trapping her in the cellar. They both end up in the hospital after a gas leak in their home. Next, Jacob and Kenny agree that Jacob can go with him to New Mexico. Malee visits Gus and removes her clothes in an attempt to seduce him. Instead, Gus calls Malee's mother to come and pick her up. The next day, Gus explains to therapist Carla about the last fire he ever fought (which involved killing an injured little girl, upon the girl's request), claiming that Malee wanted him to take her pain away, as he was aware of her growing crush on him. Meanwhile, Jacob's mother tells him that Keith Gardner wasn't adopted to replace Rudy, and that she wants Kenny dead, which reminds Jacob of his planned revenge. The night of escape for Jacob finally comes and he meets up with Kenny. Jacob insists on going through a construction site which he says is a secret route. Once there, Jacob points Gus's gun at Kenny, and tells him "you killed him" before shooting him dead. Jacob buries the body and leaves. He returns in the daytime, and sees Gus spreading cement above Kenny's grave. Malee begins visiting her estranged father and Leonard's family finally starts eating healthily. The movie ends with Jacob's mother smiling at him from inside the house.
Output: Who does Rudy want to meet in the treehouse?
Esporte Clube Corinthians played their home games at Estadio Eduardo Jose Farah, nicknamed Farahzao.
Output: What is the name of the stadium where Esporte Clube Corinthians plays home games?
The War on Terror, spanning decades, is a multi-trillion-dollar war. According to the Costs of War Project at Brown University's Watson Institute, the War on Terror will have cost $5.6 trillion for operations between 2001-2018 plus anticipated future costs of veterans' care. According to the Soufan Group in July 2015, the U.S. government was spending $9.4 million per day in operations against ISIS in Syria and Iraq. A March 2011 Congressional report estimated war spending through the fiscal year 2011 at $1.2 trillion, and future spending through 2021 at $1.8 trillion. A June 2011 academic report covering additional areas of war spending estimated it through 2011 at $2.7 trillion, and long-term spending at $5.4 trillion including interest.
Output: Who estimated a larger amount of long term spending?
Urkhao Gwra Brahma is a Member of the Parliament of India representing Assam in the Rajya Sabha, the upper house of the Indian Parliament.
Output: What is Urkhao Gwra Brahma's country of original?
Bolingbroke then reigned as King Henry IV of England (1399--1413), the first of the descendants of John of Gaunt to hold the throne of England.
Output: What was John of Gaunt's child's name?
Johann Leopold, Hereditary Prince of Saxe-Coburg and Gotha (Johann Leopold William Albert Ferdinand Victor; 2 August 1906 -- 4 May 1972) was the eldest son of Charles Edward, Duke of Saxe-Coburg and Gotha and Princess Victoria Adelaide of Schleswig-Holstein-Sonderburg-Glucksburg.
Output: Who is the mother of Johann Leopold, Hereditary Prince of Saxe-Coburg and Gotha?
According to the market research firm SuperData, as of May 2015, the global games market was worth USD 74.2 billion. By region, North America accounted for $23.6 billion, Asia for $23.1 billion, Europe for $22.1 billion and South America for $4.5 billion. By market segment, mobile games were worth $22.3 billion, retail games 19.7 billion, free-to-play Massively multiplayer online game 8.7 billion, social games $7.9 billion, PC Downloadable content 7.5 billion, and other categories $3 billion or less each.
Output: Which region was worth the least?
Hoping to rebound from a tough loss to the Patriots, the Bills would play their Week 2 home opener in an interconference duel with the Tampa Bay Buccaneers. This would be the first time that Buffalo ever hosted Tampa Bay in a regular season game, having played a preseason game with each other in 1977. In the first quarter, the Bills came out firing as quarterback Trent Edwards completed a 32-yard touchdown pass to wide receiver Lee Evans, safety Donte Whitner returning an interception 76 yards for a touchdown and kicker Rian Lindell making a 31-yard field goal. The Buccaneers would get on the board in the second quarter as quarterback Byron Leftwich completed a 42-yard touchdown pass to tight end Kellen Winslow, while Buffalo replied with Lindell getting a 43-yard field goal. Tampa Bay would close out the half as Leftwich completed an 8-yard touchdown pass to running back Carnell "Cadillac" Williams. After a scoreless third quarter, the Bills began to pull away as Lindell got a 43-yard field goal and Edwards completed a 43-yard touchdown pass to wide receiver Terrell Owens. The Buccaneers tried to rally as Leftwich completed a 6-yard touchdown pass to tight end Jerramy Stevens (with a failed two-point conversion), yet Buffalo closed out the game with Lindell nailing a 20-yard field goal. With the win, the Bills improved to 1-1.
Output: Who won against the Bills before this game?
Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, congenital heart disease, agenesis of the corpus callosum, and eye defects. The prevalence of Mowat-Wilson syndrome is currently unknown, but it seems that Mowat-Wilson syndrome is underdiagnosed, particularly in patients without Hirschsprung disease. We report here the first Egyptian case of Mowat-Wilson syndrome who was conceived by intracytoplasmic sperm injection. The patient manifested bilateral sensorineural hearing loss--a new feature not previously reported in cases of Mowat-Wilson syndrome. This report describes the first Egyptian patient of Mowat-Wilson syndrome who was conceived after intracytoplasmic sperm injection, and provides a new evidence for the inclusion of deafness among the congenital defects of the syndrome.
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Virginia Slims is a brand of cigarette manufactured by Altria Group (formerly Phillip Morris Companies).
Output: What is the product of Virginia Slims?
On 28 January the PPS and the Social Democracy of the Kingdom of Poland and Lithuania called for a general strike; over 400,000 workers became involved in strikes all over Poland, a strike that lasted for four weeks. This was only a prelude to an even larger series of strikes that rocked Poland over next year. In the years 1905-1906 close to 7,000 strikes and other work stoppages occurred, involving 1,3 million Poles. Protesters demanded both improved conditions for workers and more political freedom for the Poles. By February, students at Polish universities had joined the demonstrations, protesting russification and demanding the right to study in Polish language. They were joined by high school students and even some from the elementary schools. While the Russian government gave in and agreed to some concessions towards the Polish nationalist movement , many - particularly the workers - were still unsatisfied. In some places in Poland, the school strikes lasted for close to three years. Major demonstrations occurred on May 1 , and about 30 people were shot during a demonstration in Warsaw. Later that month, for a time, public order disintegrated in Warsaw during a spontaneous campaign against the criminal elements as well as Russian collaborators.
Output: What two countries were there strikes in?
Judah ben Asher (June 30, 1270 -- July 4, 1349) was a German Talmudist and later rabbi of Toledo, Spain, son of Rabbenu Asher and brother of Jacob ben Asher (''Ba'al ha-Turim'').
Output: Who was the brother of Judah ben Asher?
The Consecration of Aloysius Gonzaga as patron saint of youth is a c.1763 painting attributed to Francisco de Goya and now owned by the town of Jaraba but stored in the Saragossa Museum in Saragossa.
Output: What is the name of the place where Consecration of Aloysius Gonzaga as patron saint of youth can be found?
Wanted, Someone for a Kiss We're looking for producers to join us on the sound of London Kiss 100 FM. You'll work on the station's music programs. Music production experience in radio is necessary, along with rich knowledge of modern dance music. Please apply in writing to Producer Vacancies, Kiss 100. Father Christmas We're looking for a very special person, preferably over 40, to fill our Father Christmas suit. Working days: Every Saturday from November 24 to December 15 and every day from December 17 to December 24 except Sundays, 10:30-16:00. Excellent pay. Please contact the Enterprise Shopping Centre, Station Parade, Eastbourne. Accountants Assistant When you join the team in our Revenue Administration Unit, you will be providing assistance within all parts of the Revenue Division, dealing with post and other general duties. If you are educated to GCSE grade C level we would like to talk to you. This position is equally suitable for a school leaver or for somebody who has office experience. Wealden District Council. Software Trainer If you are aged 24-45 and have experience in teaching and training, you could be the person we are looking for. You should be good at the computer and have some experience in program writing. You will be allowed to make your own decisions, and to design courses as well as present them. Pay upwards of PS15,000 for the right person. Please apply by sending your CV to Mrs R.Oglivie, Palmlace Limited.
Output: Which position is open to recent school graduates?
Darrun Hilliard II (born April 13, 1993) is an American professional basketball player for the Detroit Pistons of the National Basketball Association (NBA).
Output: Which team does Darrun Hilliard play for?