niryuu/sni-each-converted huggingface dataset:
The Vikings' eleventh game was an NFC duel with the Redskins at FedExField. In the 1st quarter the Vikings trailed early as QB Donovan McNabb completed a 10-yard TD pass to TE Fred Davis. They replied as RB Adrian Peterson got a 5-yard TD run. The Vikings pulled ahead with RB Toby Gerhart getting a 5-yard TD run, followed by kicker Ryan Longwell nailing a 31-yard field goal. The Redskins tried to come back, but only came away with 40-yard and a 42-yard field goals from kicker Graham Gano, giving the Vikings the win.
Output: Who caught the longest TD pass?
You are on vacation at the beach. You take your flip-flops off so you can go swimming. The sand is so hot it hurts your feet. You have to run to the water. Now imagine if it were hot enough for the sand to melt. Some places inside Earth are so hot that rock melts. Melted rock inside the Earth is called magma. Magma can be hotter than 1,000C. When magma erupts onto Earths surface, it is known as lava, as Figure 3.17 shows. Minerals form when magma and lava cool. Most water on Earth, like the water in the oceans, contains elements. The elements are mixed evenly through the water. Water plus other substances makes a solution. The particles are so small that they will not come out when you filter the water. But the elements in water can form solid mineral deposits. Fresh water contains a small amount of dissolved elements. Salt water contains a lot more dissolved elements. Water can only hold a certain amount of dissolved substances. When the water evaporates, it leaves behind a solid layer of minerals, as Figure 3.18 shows. At this time, the particles come together to form minerals. These solids sink to the bottom. The amount of mineral formed is the same as the amount dissolved in the water. Seawater is salty enough for minerals to precipitate as solids. Some lakes, such as Mono Lake in California, or Utahs Great Salt Lake, can also precipitate salts. Salt easily precipitates out of water, as does calcite, as Figure 3.19 shows. The limestone towers in the figure are made mostly of the mineral calcite. The calcite was deposited in the salty and alkaline water of Mono Lake, in California. Calcium-rich spring water enters the bottom of the lake. The water bubbles up into the alkaline lake. The Underground water can be heated by magma. The hot water moves through cracks below Earths surface. Hot water can hold more dissolved particles than cold water. The hot, salty solution has chemical reactions with the rocks around it. The water picks up more dissolved particles. As it flows through open spaces in rocks, the water deposits solid minerals. When a mineral fills cracks in rocks, the deposits are called veins. Figure 3.20 shows a white quartz vein. When the minerals are deposited in open spaces, large crystals grow. These rocks are called geodes. Figure 3.20 shows a geode that was formed when amethyst crystals grew in an open space in a rock.
Output: Melted rock that erupts on to Earths surface is called
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasing in prevalence among asymptomatic carriers and in cases of paediatric soft-tissue infections alike. CA-MRSA may express virulence factors such as Panton-Valentine leukocidin, which makes soft-tissue and hard-tissue infections due to such organisms challenging to treat. We report a case of osteomyelitis of the proximal tibia in a 10-year-old boy and discuss its management in what is to the authors' knowledge the first case report of Panton-Valentine leukocidin-positive CA-MRSA osteomyelitis in a child in the UK.
Output: What is MRSA?
No. 288 Squadron RAF was a Royal Air Force Squadron formed as an anti-aircraft co-operation unit in World War II.
Output: What was the military branch for No. 288 Squadron RAF?
"We don't necessarily believe that new advertising, which might make consumers feel better about the Coke brand or better about the ads themselves , will actually result in consumers consuming more of the product," Morgan Stanley's Bill Pecoriello wrote in a research note the days after the investor meeting . But Coke is optimistic it can regain its old magic, and is banking on a new slogan: "Welcome to the Coke side of life." BREAK THROUGH HIT? With PepsiCo about to surpass Coke as the beverage king on Wall Street--Pepsi's market capitalization has _ in recent years to $97.9 billion, putting it less than a billion dollars behind its rival--the heat is on Coke . It's set to launch a new marketing campaign in March, 2006. And having taken a quick look at Coke's investor presentation on Dec. 7 in New York, my sense is that Coke may be moving in the right direction . Given the continued shift by consumers away from soda--Coke's stronghold --and into alternative beverages like juice, tea, and water, Coke badly needs a breakthrough hit. And given that shift away from soda, some analyists wonder whether even the catchiest new ads will be enough to put the fizz back into Coke. SAME OLD, UPDATED? The new flavors of PowerAde sports drink will probably enable Coke to continue stealing market share from PepsiCo's Gatorade brand. And Coke is getting a little more creative with packaging, including new, aluminum bottles of Coke that will be sold in nightclubs, and an 8.4-ounce "100 calorie" version of its flagship Coke that will appeal to women who want fewer calories and will like the fact that the small can will fit in their purse. I doubt whether other new products will be successful, including a new coffee-flavored soda called Coke-Cola Black that I tried. Think carbonated coffee. But I'm not sure if the product, which Coke is pitching as an afternoon pick-me-up for the 35-and-over set, is going to pull people away from their afternoon Frappucino fix. And my opinion is that Vault, an orange-flavored energy drink, will have just as much trouble unseating Mountain Dew among teens as did Coke's last attempt, a product called Surge. If there is one concern I have about the fresh offerings Coke plans to launch this year, it appears that many of them are simply new brands, not new products.
Output: When the middle-aged people feel tired, what would they prefer to drink in order to continue their work?
As the film begins, Daisy Duck is talking to a psychiatrist about an incident that occurred with her boyfriend, Donald. She recalls how they were walking through the park, passing by a skyscraper. On the 99th floor of the skyscraper is a potted flower, which falls and hits Donald on the head, knocking him out. When he comes to, he hears a voice in his head, telling him, "You are the greatest singer in the world." He gets up, and proceeds to croon "When You Wish upon a Star" in a Sinatra-like voice. Daisy is stunned, but Donald coldly glances at her as though he does not recognize her. At that moment, a theatrical agent sweeps Donald into his window, causing the flower on his head to fall at Daisy's feet.She takes the flower home, as a way to remember her lost love. She sees Donald everywhere, hawking products and on marquees-- he has become a major celebrity. She almost drives herself insane, but eventually hears that Donald is playing at the Music City Radio Hall. She decides to go see him, but is greatly hindered by a massive crowd. Many months pass, during which Daisy has no success at being able to see Donald.One night, as she is going home, she runs into Donald on the street. She grovels at Donald's feet, but only succeeds in getting a dime thrown at her. She then comes back to the present, where she is talking to the psychiatrist about what happened. The psychiatrist concludes that the hit on the head from the flower pot is what caused Donald to change so radically. He offers to help, but warns her that Donald will no longer be successful if he changes back to normal. Daisy is eager to have him back, though, so the psychiatrist tells her to put the flower in another pot and drop it on Donald's head somehow. She agrees to this plan.That night, as Donald is performing, Daisy slips into the building through the back door. She makes her way past a sleeping security guard, and climbs up into the rafters, where she drops the pot on Donald. It hits him on the head, and he quickly reverts to his regular voice. He is booed off the stage and thrown out of the building, where Daisy is waiting for him. He is thrilled to see her, asking, "Where have you been?" They kiss as the film irises out.
Output: What fell on Donald's head?
Abdali invaded the Mughal Empire seven times from 1748 to 1767. According to Jaswant Lal Mehta, Durrani aroused the Afghans "religious passions" to fire and "sword into the land of infidels India." He crossed the Khyber pass in December 1747 with 40,000 troops for his first invasion of India. He occupied Peshawar without any opposition. He first crossed the Indus River in 1748, the year after his ascension- his forces sacked and absorbed Lahore. The following year , the Mughal ruler was induced to cede Sindh and all of the Punjab including the vital trans Indus River to him, in order to save his capital from being attacked by the forces of the Durrani Empire. Having thus gained substantial territories to the east without a fight, Durrani and his forces turned westward to take possession of Herat, which was ruled by Nader Shah's grandson, Shah Rukh. The city fell to the Afghans in 1750, after almost a year of siege and bloody conflict; the Afghan forces then pushed on into present-day Iran, capturing Nishapur and Mashhad in 1751. Durrani then pardoned Shah Rukh and reconstituted Khorasan, but a tributary of the Durrani Empire. This marked the westernmost border of the Afghan Empire as set by the Pul-i-Abrisham, on the Mashhad-Tehran road.
Output: When did Afghans take Herat
Chronicles of Avonlea is a collection of short stories by L. M. Montgomery, related to the Anne of Green Gables series.
Output: What series is the episode Chronicles of Avonlea part of?
The water that comes out of our faucets is safe because it has gone through a series of treatment and purification processes to remove contaminants. Those of us who are fortunate enough to always be able to get clean water from a tap in our home may have trouble imagining life in a country that cannot afford the technology to treat and purify water. Many people in the world have no choice but to drink from the same polluted river where sewage is dumped. One- fifth of all people in the world, more than 1.1 billion people, do not have access to safe water for drinking, personal cleanliness, and domestic use. Unsafe drinking water carries many pathogens, or disease-causing biological agents such as infectious bacteria and parasites. Toxic chemicals and radiological hazards in water can also cause diseases. Waterborne disease caused by unsafe drinking water is the leading cause of death for children under the age of five in many nations and a cause of death and illness for many adults. About 88% of all diseases are caused by drinking unsafe water (Figure 1.1). Throughout the world, more than 14,000 people die every day from waterborne diseases, such as cholera, and many of the worlds hospital beds are occupied by patients suffering from a waterborne disease. Guinea worm is a serious problem in parts of Africa that is being eradicated. Learn what is being done to decrease the number of people suffering from this parasite at the video below. Click image to the left or use the URL below. URL:
Output: ________________ of all people in the world have access to safe water for drinking, personal cleanliness, and domestic use.
Antisense therapy with both chemistries of phosphorodiamidate morpholino oligomers (PMOs) and 2'-O-methyl phosphorothioate has demonstrated the capability to induce dystrophin expression in Duchenne muscular dystrophy (DMD) patients in phase II-III clinical trials with benefit in muscle functions. However, potential of the therapy for DMD at different stages of the disease progression is not understood. In this study, we examined the effect of peptide-conjugated PMO (PPMO)-mediated exon skipping on disease progression of utrophin-dystrophin-deficient mice (dko) of four age groups (21-29, 30-39, 40-49 and 50+ days), representing diseases from early stage to advanced stage with severe kyphosis. Biweekly intravenous (i.v.) administration of the PPMO restored the dystrophin expression in nearly 100% skeletal muscle fibers in all age groups. This was associated with the restoration of dystrophin-associated proteins including functional glycosylated dystroglycan and neuronal nitric synthase. However, therapeutic outcomes clearly depended on severity of the disease at the time the treatment started. The PPMO treatment alleviated the disease pathology and significantly prolonged the life span of the mice receiving treatment at younger age with mild phenotype. However, restoration of high levels of dystrophin expression failed to prevent disease progression to the mice receiving treatment when disease was already at advanced stage. The results could be critical for design of clinical trials with antisense therapy to DMD.
Output: In what percentage of skeletal muscle fibers is dystrophin expression restored after PPMO- mediated exon skipping?
TDRS-11 was launched at 01:48 UTC on 31 January 2013, at the beginning of a 40-minute launch window.
Output: On what date did TDRS-11 take off?
Damien Ryan (born 20 September 1979) is an Australian professional basketball player.
Output: Which sport does Damien Ryan practice?
The Villa Empain is a private house in the Art Deco style designed and built between 1930 and 1934 by Swiss architect Michel Polak for Baron Louis Empain, son of Belgian industrialist Baron Edouard Empain, located in Brussels, Belgium.
Output: Which is the kind of art style of Villa Empain?
However, due to the U.S. Army's recent reorganization, only 4th Squadron remains in active service. 4th Squadron, 10th Cavalry takes its history and lineage from D Troop, 10th Cavalry. In 2000, D Troop, 10th U.S. Cavalry, was reactivated and assigned as the brigade reconnaissance troop for 3rd Brigade Combat Team, 3rd Infantry Division at Fort Benning, Georgia. D Troop, 10th Cavalry was deployed with 3/3 ID to Iraq in 2003, and was deactivated upon redeployment in 2004. It was reactivated in October 2007 at Fort Carson, Colorado, replacing the 2nd Squadron, 9th Cavalry regiment, as the 4th Squadron, 10th Cavalry Regiment with A, B, C, and HQ Troops as the reconnaissance squadron for 3rd Combat Brigade Team of the 4th Infantry Division. The 4th Squadron deployed to Iraq with the BCT from December 2007 to February 2009, and again in March 2010. The Squadron deployed to Jordan in 2015 in support of Operation Spartan Shield. In February 2016, Delta Tank Company from 1st Battalion, 8th Infantry Regiment moved to 4th Squadron, 10th Cavalry Regiment to be assigned as Dakota Troop. As of February 2016, 4th Squadron, 10th Cavalry Regiment is the only current active unit of the 10th Cavalry Regiment.
Output: What branch of the military is the 4th Squadron?
Despite that deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favored intervention for patients with medically intractable dystonia, the pathophysiological mechanisms of dystonia are largely unclear. In eight patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, we correlated symptom-related electromyogram (EMG) activity of the most affected muscles with the local field potentials (LFPs) recorded from the globus pallidus electrodes. In 5 dystonic patients with mobile involuntary movements, rhythmic EMG bursts in the contralateral muscles were coherent with the oscillations in the pallidal LFPs at the burst frequency. In contrast, no significant coherence was seen between EMG and LFPs either for the sustained activity separated out from the compound EMGs in those 5 cases, or in the EMGs in 3 other cases without mobile involuntary movements and rhythmic EMG bursts. In comparison with the resting condition, in both active and passive movements, significant modulation in the GPi LFPs was seen in the range of 8-16 Hz. The finding of significant coherence between GPi oscillations and rhythmic EMG bursts but not sustained tonic EMG activity suggests that the synchronized pallidal activity may be directly related to the rhythmic involuntary movements. In contrast, the sustained hypertonic muscle activity may be represented by less synchronized activity in the pallidum. Thus, the pallidum may play different roles in generating different components of the dystonic symptom complex.
Output: Neurostimulation of which nucleus is used for treatment of dystonia?
Like all organisms, bacteria need energy, and they can acquire this energy through a number of different ways. Photosynthetic bacteria use the energy of the sun to make their own food. In the presence of sunlight, carbon dioxide and water are turned into glucose and oxygen. The glucose is then turned into usable energy. Glucose is like the "food" for the bacteria. An example of photosynthetic bacteria is cyanobacteria, as seen in the opening image. These bacteria are sometimes called blue-green algae, although they are not algae, due to their numerous chlorophyll molecules. Bacteria known as decomposers break down wastes and dead organisms into smaller molecules. These bacteria use the organic substrates they break down to get their energy, carbon, and nutrients they need for survival. Bacteria can also be chemotrophs. Chemosynthetic bacteria, or chemotrophs, obtain energy by breaking down chemical compounds in their environment. An example of one of these chemicals broken down by bacteria is nitrogen-containing ammonia. These bacteria are important because they help cycle nitrogen through the environ- ment for other living things to use. Nitrogen cannot be made by living organisms, so it must be continually recycled. Organisms need nitrogen to make organic compounds, such as DNA. Some bacteria depend on other organisms for survival. For example, some bacteria live in the roots of legumes, such as pea plants ( Figure 1.1). The bacteria turn nitrogen-containing molecules into nitrogen that the plant can use. Meanwhile, the root provides nutrients to the bacteria. In this relationship, both the bacteria and the plant benefit, so it is known as a mutualism. Other mutualistic bacteria include gut microbes. These are bacteria that live in the intestines of animals. They are usually beneficial bacteria, needed by the host organism. These microbes obviously dont kill their host, as that would kill the bacteria as well. Other bacteria are parasitic and can cause illness. In parasitism, the bacteria benefit, and the other organism is harmed. Harmful bacteria will be discussed in another concept.
Output: nitrogen gas in the atmosphere has a strong bond that cannot be broken by many organisms. instead bacteria break the bond so other organisms have access to the nitrogen. organisms need nitrogen to make
Cystic fibrosis (CF) is the most common inherited disorder in Caucasian populations, with over 1400 mutations identified in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. Mutations in the CFTR gene may be also causative for CBAVD (Congenital Bilateral Absence of the Vas Deferens). The type and distribution of mutations varies widely between different countries and/or ethnic groups, and is relatively unknown in Iran. We therefore performed a comprehensive analysis of the CFTR gene in Iranian CF patients. 69 Iranian CF patients, and 1 CBAVD patient, were analysed for mutations in the complete coding region, and its exon/intron junctions, of their CFTR genes, using different methods, such as ARMS (amplification refractory mutation system)-PCR, SSCP (single stranded conformation polymorphism) analysis, restriction enzyme digestion analysis, direct sequencing, and MLPA (Multiplex Ligation-mediated Probe Amplification). CFTR mutation analysis revealed the identification of 37 mutations in 69 Iranian CF patients. Overall, 81.9% (113/138) CFTR genes derived from Iranian CF patients could be characterized for a disease-causing mutation. The CBAVD patient was found to be homozygous for the p.W1145R mutation. The most common mutations were p.F508del (DeltaF508) (18.1%), c.2183_2184delAAinsG (2183AA>G) (6.5%), p.S466X (5.8%), p.N1303K (4.3%), c.2789+5G>A (4.3%), p.G542X (3.6%), c.3120+1G>A (3.6%), p.R334W (2.9%) and c.3130delA (2.9%). These 9 types of mutant CFTR genes totaled for 52% of all CFTR genes derived from the 69 Iranian CF patients. Eight mutations, c.406-8T>C, p.A566D, c.2576delA, c.2752-1_2756delGGTGGCinsTTG, p.T1036I, p.W1145R, c.3850-24G>A, c.1342-?_1524+?del, were found for the first time in this study. We identified 37 CFTR mutations in 69 well characterized Iranian CF patients, obtaining a CFTR mutation detection rate of 81.9%, the highest detection rate obtained in the Iranian population so far. These findings will assist in genetic counseling, prenatal diagnosis and future screening of CF in Iran.
Output: Which is the most common CFTR mutation in Caucasians?
The Van Gogh Museum's Wheatfield with Crows was painted in July 1890, in the last weeks of van Gogh's life.
Output: What is the name of the place where Wheatfield with Crows can be found?
Noar Linhas Aereas Flight 4896 was a passenger flight which crashed in Boa Viagem, Recife, Brazil, on 13 July 2011.
Output: What was the date of Noar Linhas Aéreas Flight 4896?
U.S. Bottled Water Sales Are Booming Again Despite Opposition Despite organized anti-bottled-water campaigns across the country and a noisy debate about bottled water's environmental impact, Americans are buying more bottled water than ever. Why do so many people seem to think they should have any input on what other American's choose to buy or do? If they want to buy bottled water, let them. If they want to eat fast food, let them. If they want to smoke pot, let them. -- Barackalypse People just get tired of paying for others' bad behavior. If many people eat excessive fast food, you pay higher insurance premiums. If many people frequently buy bottled water, your trash bills go up and landfills fill up quickly.www.zxxk.com It's about personal responsibility, which really should be a cornerstone of libertarianism. -- Bdbr So? This is the price you pay to live in a free society. You want to control the life of another just so you can save a few bucks? What would you say when someone do the same to you? -- Norman619 Defend selfish pricks all you like; I'm just glad there are still people who still believe personal responsibility is a good and decent thing. We make your life cheaper and less bothersome. -- Yoyo What a waste of money! It's fine when you're on the road and you need a cold drink, but people who buy cases of bottled water for home are completely crazy. -- Agmlauncher I wish we all can find a way to improve things and benefit from this. The environment needs a lot of help but businesses will always work on what people would need and demand. Is this part of the balance? Hope we can find better ways. -- Skipweis
Output: Who would agree with Barackalypse on this matter?
We report the development of OikoBase ([Link] a tiling array-based genome browser resource for Oikopleura dioica, a metazoan belonging to the urochordates, the closest extant group to vertebrates. OikoBase facilitates retrieval and mining of a variety of useful genomics information. First, it includes a genome browser which interrogates 1260 genomic sequence scaffolds and features gene, transcript and CDS annotation tracks. Second, we annotated gene models with gene ontology (GO) terms and InterPro domains which are directly accessible in the browser with links to their entries in the GO ([Link] and InterPro ([Link] databases, and we provide transcript and peptide links for sequence downloads. Third, we introduce the transcriptomics of a comprehensive set of developmental stages of O. dioica at high resolution and provide downloadable gene expression data for all developmental stages. Fourth, we incorporate a BLAST tool to identify homologs of genes and proteins. Finally, we include a tutorial that describes how to use OikoBase as well as a link to detailed methods, explaining the data generation and analysis pipeline. OikoBase will provide a valuable resource for research in chordate development, genome evolution and plasticity and the molecular ecology of this important marine planktonic organism.
Output: Mention the only available genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica
Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that uses cysteine residues to decompose peroxides. Prx2 is the third most abundant protein in erythrocytes, and competes effectively with catalase and glutathione peroxidase to scavenge low levels of hydrogen peroxide, including that derived from hemoglobin autoxidation. Low thioredoxin reductase activity in the erythrocyte is able to keep up with this basal oxidation and maintain the Prx2 in its reduced form, but exposure to exogenous hydrogen peroxide causes accumulation of the disulfide-linked dimer. The high cellular concentration means that although turnover is slow, erythrocyte Prx2 can act as a noncatalytic scavenger of hydrogen peroxide and a sink for hydrogen peroxide before turnover becomes limiting. The consequences of Prx2 oxidation for the erythrocyte are not well characterized, but mice deficient in this protein develop severe hemolytic anemia associated with Heinz body formation. Prx2, also known as calpromotin, regulates ion transport by associating with the membrane and activating the Gardos channel. How Prx2 redox transformations are linked to membrane association and channel activation is yet to be established. In this review, we discuss the functional properties of Prx2 and its role as a major component of the erythrocyte antioxidant system.
Output: What type of enzyme is peroxiredoxin 2 (PRDX2)?
A huge cloud of dust rose and an overpass disappeared. This was the scene in Zhuzhou,Hunan Province on May 17.Nine people were killed and 16 injured. Things were similar last year in the Sichuan earthquake. Thousands of people were buried in the ruins and lost their lives. What if we could have warned them? People are always _ to find a way of preventing buildings' collapse. Better materials and technology help,but they are not a solution. Just like humans,a building has its own life cycle from "birth" to "death".If we know when a building is going to collapse,we can repair it in advance or get out of it before it falls. Now,scientists at the University of Illinois have developed a material that turns red before it breaks. The invention could be used in things like climbing ropes or bridge supports. The research was led by Nancy Sottos,a professor at the university's Beckman Institute,and Douglas Davis,a graduate research assistant. The secret behind the colorchanging material is a type of molecule .A molecule is a group of atoms held together by chemical bonds. Imagine you and your friends standing in a circle,holding hands. Each person stands for one atom,your hands represent the bonds,and the entire circle represents a molecule. If one person lets go of his or her hands,the molecule changes color. The research team put the molecule into a soft material. When the researchers stretched the material,it turned bright red for a few seconds before it broke into two pieces. When they repeatedly stretched and relaxed the material,without breaking it,it only turned a little red. The major problem is that light can get rid of the red color. When the team shone bright light on the molecule,the broken bond was fixed,and the color disappeared. If the bright light keeps the red color from appearing,the material's warning system will be useless. Scientists still have a lot of work to do before the colorchanging molecules can be used outside the lab.
Output: What does the passage mainly introduce?
Si Renfa's son Si Jifa escaped and continued independent action in another corner of southwest Yunnan. He sent his younger brother Zhaosai to seek pardon from Ming while at the same time he attacked Ming troops in early 1443. However they were defeated and he was forced to flee to Mong Yang. Zhaosai was kept as a hostage and the Ming retreated from Mong Mao. Seeing that Mong Mao was no longer occupied, Si Jifa returned to his father's base of power and began attacking neighboring tribes once again. The third punitive expedition was led by Wang Ji and launched in March 1443. Although the mission was to capture Si Jifa, negotiations on the return of Si Renfa had fallen ill. Ava demanded Ming territory for itself and Hsenwi in return of Si Renfa. Furthermore Ava had made peace with Si Jifa. Therefore, although the Ming army quickly defeated Si Jifa's base of power and captured his family, Si Jifa managed to escape to Mong Yang, and the Ming army decided not to pursue out of consideration of a combined Ava-Hsenwi attack on Ming forces. A compromise was finally reached between Ava and Ming in April 1445. Ava agreed to hand over Si Renfa in return for Ming support in annexing part of Hsenwi's territory. Si Renfa came into Ming custody in August 1445 and was executed in January 1446.
Output: Who attacked Min troops in early 1443?
The Grandes etudes de Paganini, S. 141, are a series of six etudes for the piano by Franz Liszt, revised in 1851 from an earlier version (published as Etudes d'execution transcendante d'apres Paganini, S.140, in 1838).
Output: On which instrument(s) was Grandes études de Paganini created to be played on?
Margaret Power is a fictional character in the Marvel Universe.
Output: What is the name of the fictional universe that Margaret Power is from?
The film tells the story of a psychiatrist, Dr. Cross (Vincent Price), who is treating a young woman, Janet Stewart (Anabel Shaw), who is in a coma-state, brought on when she heard loud arguing, went to her window and saw a man strike his wife with a candlestick and kill her. It also stars Lynn Bari as Dr. Cross's nurse/lover, Elaine Jordan. As Stewart comes out of her shock, she recognizes Dr. Cross as the killer. He then takes her to his sanitarium and at Elaine's urging, gives Janet an overdose of insulin under the pretense of administering insulin shock therapy. He can't bring himself to murder her in cold blood, though, and asks Elaine to get the medicine to save her. Elaine refuses, they argue, and he strangles her. A colleague of Dr. Cross, Dr. Harvey, saves Janet's life and Dr. Cross is taken into custody by a lawyer from the District Attorney's office.
Output: Who is the killer?
To investigate the clinical feature of Parkinson's disease (PD) with restless leg syndrome (RLS) and the pathogenesis of RLS. We conducted a cross-sectional and control study. The case group concluded 31 PD with RLS patients, meanwhile 39 PD patients were selected as the control group. Clinical history, clinical manifestations, complications and laboratory examinations were compared respectively between the two groups. All the RLS symptoms did not appear in RLS patients until the PD symptoms came out. Significant differences were found in complications such as swallow disturbance, constipation and illusion, when we compared the two PD groups (P < 0.05). Compared with the PD or healthy group, the level of serum ferritin and the H-reflex latency of tibial nerve were significantly decreased in PD with RLS group (P < 0.05). Secondary RLS is a complication of PD. Deficiency of iron and decreased inhibition function of spinal cord may lead to the occurrence of RLS in PD patients. When their motor symptoms are serious and complications are more common, PD patients are more possible to have RLS symptoms.
Output: Which deficiency is the cause of restless leg syndrome?
Learn to Communicate with Others Talking to Teachers--Teachers are just people behind the desk, living breathing human beings. And they will probably be friendly to people who talk nicely to them. Teachers also seem to get along better with children who take schoolwork seriously and prepare for class. And, just like any other human being, teachers like to be appreciated. The next time your teacher helps you solve a math problem or figure out a science project, say thank you with a smile. Talking to Parents--Parents can be very supportive if their children ask for help. If you think there's something your parents can do to help you feel more comfortable around people, then ask them. Very often, parents want very much to help, but really don't know what to do. Pick a quiet time of the day and ask to talk. Tell them how you feel. Maybe they had the same trouble when they were kids. Talking to Strangers--This is always a tough one. How do you deal with a neighbor, or the mail carrier? That often seems to cause arguments between kids and parents. The answer to these questions will vary from kid to kid, from parent to parent because all cultures are different. Some folks live in small towns where a hello to everyone is ok. Then there are kids who live in the city who may have been taught not to speak to anyone they don't know. If you're having trouble with this and always feel awkward in these kinds of situations, you might want to talk to your parents or a teacher about it.
Output: Who does the writer write this passage for?
An alloy is a mixture of a metal with one or more other elements. The other elements may be metals, nonmetals, or both. An alloy is formed by melting a metal and dissolving the other elements in it. The molten solution is then allowed to cool and harden. Alloys generally have more useful properties than pure metals. Several examples of alloys are described and pictured below. If you have braces on your teeth, you might even have this alloy in your mouth! Click image to the left or use the URL below. URL: Most metal objects are made of alloys rather than pure metals. Objects made of four different alloys are shown in the Figure 1.1. Brass saxophone: Brass is an alloy of copper and zinc. It is softer than bronze and easier to shape. Its also very shiny. Notice the curved pieces in this shiny brass saxophone. Brass is used for shap- ing many other curved objects, such as doorknobs and plumbing fixtures. Stain- less steel sink: Stainless steel is a type of steel that contains nickel and chromium in addition to carbon and iron. It is shiny, strong, and resistant to rusting. This makes it useful for sinks, eating utensils, and other objects that are exposed to wa- ter. "Gold" bracelet: Pure gold is relatively soft, so it is rarely used for jewelry. Most "gold" jewelry is actually made of an alloy of gold, copper and silver. Bronze statue: Bronze was the first alloy ever made. The earliest bronze dates back many thou- sands of years. Bronze is a mixture of copper and tin. Both copper and tin are relatively soft metals, but mixed together in bronze they are much harder. Bronze has been used for statues, coins, and other objects. Q: Sterling silver is an alloy that is used to make fine jewelry. What elements do you think sterling silver contains? What properties might sterling silver have that make it more useful than pure silver? A: Most sterling silver is about 93 percent silver and about 7 percent copper. Sterling silver is harder and stronger than pure silver, while retaining the malleability and luster of pure silver.
Output: the first alloy ever made was
It is winter in many parts of the world. For some areas, that means snow. Maybe even lots of snow. If you don't have to drive in it or remove it, snow can be very beautiful. When snow covers everything around you, the world looks like a "winter wonderland". That is the name of a very popular song about winter. Richard Smith and Felix Bernard wrote the song back in 1934. There are hundreds of recordings of this happy song. But winter is not always such a beautiful and happy time. It's cold outside. You try hard to keep warm. The days are darker and shorter. The sun rarely shines. The leaves on the trees are brown. It isn't surprising that some people are sad in winter. And some people dream about being somewhere else where it's warm and pretty--like the state of California. The Mamas and the Papas recorded this famous song "California Dreaming". During the 1960s, many other famous rock groups released songs about winter. Here is a poetic song by Simon and Garfunkel called "A Hazy Shade of Winter". They sing about life and hope and possibilities. In 1968, the group Blood, Sweat and Tears recorded this gentle, sad song about winter. They sing about a lost love and forgotten memories in "Sometimes in Winter". In the early 1990s, Tori Amos wrote and recorded the beautiful song called "Winter". She enjoyed singing about winter when she was a child. Finally, on a happier note comes this song written and recorded by Fountains of Wayne in 2003. They sing about a snowstorm in a New England town. Nothing unusual there. But instead of being sad or tense about the snow, they write a song about it.
Output: Which of the songs can bring us hope of life?
The deflated Giants traveled to Minnesota to take on the Vikings. Already eliminated from the playoffs due to Washington beating Philadelphia the night before to secure the NFC East for the first time since 2012, they were without their star wide receiver Odell Beckham Jr. as he was suspended for his actions in a Week 15 loss against Carolina. The Vikings stingy defense put pressure on Eli Manning all game, forcing Tom Coughlin to bench Manning after three interceptions. The Giants defense was not a factor as they failed to contain the Vikings rushing attack all game long. Linebacker JT Thomas was ejected from the game in the 4th quarter for throwing a punch. The loss of Beckham was too steep to overcome and the Giants wound up losing 49-17, dropping to 6-9.
Output: Which team won the game?
Ehlers-Danlos syndrome type 4, the vascular type, is a rare, life-threatening inherited disorder of the connective tissue. Affected patients are at risk of arterial, bowel and uterine rupture during pregnancy. Generally, this syndrome remains undiagnosed until a sudden, acute presentation with organ rupture, and results in premature death, even if the patients survive the first and second major complications. An early diagnosis with genetic assays can help to plan the best treatment, which is often challenging due to the frailty of the arterial tissue. We report on a 28-year-old lady who presented with spontaneous rupture of a pseudoaneurysm of the posterior tibial artery.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
Josef Marek (born 11 June 1987) is a professional Czech football player who plays for FK Viktoria Zizkov.
Output: When is the date of birth of Josef Marek?
Evaluate efficacy and safety of tanezumab, a humanized monoclonal antibody against nerve growth factor, in neuropathic pain. Two randomized controlled trials. Patients with pain due to diabetic peripheral neuropathy (DPN) or postherpetic neuralgia (PHN). In the DPN study, patients received subcutaneous tanezumab 20 mg or placebo on Day 1 and Week 8. Evaluations included change from baseline in average DPN pain (primary endpoint), Patient's Global Assessment of DPN, and safety (including neuropathy assessments). Due to a partial clinical hold limiting enrollment and treatment duration, the prespecified landmark analysis was modified post hoc from Week 16 to Week 8. In the PHN study, patients received intravenous tanezumab 50 g/kg, tanezumab 200 g/kg, or placebo on Day 1. Evaluations included change from baseline in average daily pain (primary endpoint), Brief Pain Inventory-short form, Patient's Global Assessment of pain from PHN, and safety. Mean DPN pain reduction from baseline to Week 8 was greater with tanezumab vs placebo (P = 0.009); differences in Patient's Global Assessment of DPN were not significant (P > 0.05). Neither tanezumab dose resulted in significant differences vs placebo in efficacy in PHN (P > 0.05), although tanezumab 200 g/kg provided some benefit. Neuropathy assessments showed no meaningful changes. Tanezumab provided effective pain reduction in DPN. In PHN, only the highest tanezumab dose reduced pain; treatment differences were not significant. No new safety concerns were observed despite preexisting neuropathy.
Output: What is the target of tanezumab?
Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t(9;22)(q34;q11). This translocation creates two new genes, BCR-ABL on the 22q- (Ph chromosome) and the reciprocal ABL-BCR on 9q-. The BCR-ABL gene encodes for a 210-kD protein with deregulated tyrosine kinase (TK) activity, which is crucial for malignant transformation in CML. The recognition of the BCR-ABL gene and corresponding protein led to the synthesis of small-molecule drugs, designed to interfere with BCR-ABL tyrosine kinase activation by competitive binding at the ATP-binding site. The first tyrosine kinase inhibitor (TKI), introduced into clinical practice in 1998, was imatinib mesylate. Imatinib became the first choice drug in chronic phase CML, because of its high efficacy, low toxicity and ability to maintain durable hematological and cytogenetic responses. However, approximately 20-25% of patients initially treated with imatinib will need alternative therapy, due to drug resistance, which is often caused by the appearance of clones expressing mutant forms of BCR-ABL. Second-generation TKIs have provided new therapeutic option for the patients resistant to imatinib. Dasatinib is the first, second-generation TKI, approved in the US and European Union for the treatment of CML patients with imatinib resistance or intolerance. This drug is a dual SRC-ABL kinase inhibitor, active in most clinically relevant BCR-ABL mutations, except highly resistant T315I. Other second-generation TKIs include nilotinib, bosutinib and INNO 406. Apart from TKIs, the promising group of molecules is inhibitors of Aurora family of serine-threonine kinases. One of these molecules, MK0457, has entered clinical trials, and initial reports indicate that this compound could be active in disease associated with T315I mutation. Thus, wide spectrum of new agents, with different mode of action, is currently in clinical development for CML. It is likely that combination therapy will be the best therapeutic strategy in the future.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Soil is a complex mixture of different materials. About half of most soils are inorganic materials, such as the products of weathered rock, including pebbles, sand, silt, and clay particles. About half of all soils are organic materials, formed from the partial breakdown and decomposition of plants and animals. The organic materials are necessary for a soil to be fertile. The organic portion provides the nutrients, such as nitrogen, needed for strong plant growth. In between the solid pieces, there are tiny spaces filled with air and water. Within the soil layer, important reactions between solid rock, liquid water, air, and living things take place. In some soils, the organic portion could be missing, as in desert sand. Or a soil could be completely organic, such as the materials that make up peat in a bog or swamp (Figure 1.1). The inorganic portion of soil is made of many different size particles, and these different size particles are present in different proportions. The combination of these two factors determines some of the properties of the soil. A permeable soil allows water to flow through it easily because the spaces between the inorganic particles are large and well connected. Sandy or silty soils are considered "light" soils because they are permeable, water-draining types of soils. Soils that have lots of very small spaces are water-holding soils. For example, when clay is present in a soil, the soil is heavier, holds together more tightly, and holds water. When a soil contains a mixture of grain sizes, the soil is called a loam (Figure 1.2). A loam field. When soil scientists want to precisely determine soil type, they measure the percentage of sand, silt, and clay. They plot this information on a triangular diagram, with each size particle at one corner (Figure 1.3). The soil type can then be determined from the location on the diagram. At the top, a soil would be clay; at the left corner, it would be sand; at the right corner, it would be silt. Soils in the lower middle with less than 50% clay are loams. Soil types by particle size. Soil is an ecosystem unto itself. In the spaces of soil, there are thousands or even millions of living organisms. Those organisms could include earthworms, ants, bacteria, or fungi (Figure 1.4).
Output: soil that is so rich in organic matter it can be burned is called
Sperm ( Figure 1.1), the male reproductive cells, are tiny. In fact, they are the smallest cells in the human body. What do you think a sperm cell looks like? Some people think that it looks like a tadpole. Do you agree? A sperm has three main parts: 1. The head of the sperm contains the nucleus. The nucleus holds the DNA of the cell. The head also contains enzymes that help the sperm break through the cell membrane of an egg. 2. The midpiece of the sperm is packed with mitochondria. Mitochondria are organelles in cells that produce energy. Sperm use the energy in the midpiece to move. 3. The tail of the sperm moves like a propeller, around and around. This tail is a long flagella that pushes the sperm forward. A sperm can travel about 30 inches per hour. This may not sound very fast, but dont forget how small a sperm is. For its size, a sperm moves about as fast as you do when you walk briskly. This drawing of a sperm shows its main parts. What is the role of each part? How do you think the shape of the sperm might help it swim? To make sperm, cells start in the testes and end in the epididymis. It takes up to two months to make sperm. The steps are explained below: 1. Special cells in the testes go through mitosis (cell division) to make identical copies of themselves. 2. The copies of the original cells divide by meiosis, producing cells called spermatids. The spermatids have half the number of chromosomes as the original cell. The spermatids are immature and cannot move on their own. 3. The spermatids are transported from the testes to the epididymis. Involuntary muscular contraction moves the spermatids along. 4. In the epididymis, spermatids slowly grow older and mature. They grow a tail. They also lose some of the cytoplasm from the head. It is here that the spermatids mature, becoming sperm cells. 5. When sperm are mature, they can swim. The mature sperm are stored in the epididymis until it is time for them to leave the body. Sperm leave the epididymis through the vas deferens. As they travel through the vas deferens, they pass by the prostate and other glands. The sperm mix with liquids from these glands, forming semen. The semen travels through the urethra and leaves the body through the penis. A teaspoon of semen may contain as many as 500 million sperm!
Output: what part of the sperm cell contains many mitochondria?
The Antinous Farnese is a specific marble sculptural representation of Antinous, named after its one-time owners the Farnese family.
Output: What material was used for Antinous Farnese?