niryuu/sni-each-converted huggingface dataset:
Besides entertainment and beautiful lanterns, another important part of the Lantern Festival, or Yuanxiao Festival is eating small dumpling balls made of glutinous rice flour. We call these balls Yuanxiao or Tangyuan. Obviously, they get the name from the festival itself. It is said that the custom of eating Yuanxiao originated during the Eastern Jin Dynasty in the fourth century, then became popular during the Tang and Song periods. The fillings inside the dumplings or Yuansiao are either sweet or salty. Sweet fillings are made of sugar, Walnuts, sesame , osmanthus flowers , rose petals, sweetened tangerine peel, bean paste, or jujube paste . A single ingredient or any combination can be used as the filling . The salty variety is filled with minced meat , vegetables or a mixture. The way to make Yuanxiao also varies between northern and southern China. The usual method followed in southern provinces is to shape the dough of rice flour into balls, make a hole, insert the filling, then close the hole and smooth out the dumpling by rolling it between your hands. In North China, sweet or nutmeat stuffing is the usual ingredient. The fillings are pressed into hardened cores, dipped lightly in water and rolled in a flat basket containing dry glutinous rice flour. A layer of the flour sticks to the filling, which is then again dipped in water and rolled a second time in the rice flour. And so it goes, like rolling a snowball, until the dumpling is the desired size. The custom of eating Yuanxiao dumplings remains. This tradition encourages both old and new stores to promote their Yuanxiao products. They all try their best to improve the taste and quality of the dumplings to attract more customers.
Output: Which country does the Lantern Festival come from?
Sweet Weaponry is the first studio album by the pop punk band Cruiserweight.
Output: Who sang or played Sweet Weaponry?
In post-traumatic stress disorder (PTSD) there is a need for self-rating scales that are sensitive to treatment effects and have been tested in a broad range of trauma survivors. Separate measures of frequency and severity may also provide an advantage. Three hundred and fifty-three men and women completed the Davidson Trauma Scale (DTS), a 17-item scale measuring each DSM-IV symptom of PTSD on 5-point frequency and severity scales. These subjects comprised war veterans, survivors of rape or hurricane and a mixed trauma group participating in a clinical trial. Other scales were included as validity checks as follows: Global ratings, SCL-90-R, Eysenck Scale, Impact of Event Scale and Structured Clinical Interview for DSM-III-R. The scale demonstrated good test-retest reliability (r = 0.86), internal consistency (r = 0.99). One main factor emerged for severity and a smaller one for intrusion. In PTSD diagnosed subjects, and the factor structure more closely resembled the traditional grouping of symptoms. Concurrent validity was obtained against the SCID, with a diagnostic accuracy of 83% at a DTS score of 40. Good convergent and divergent validity was obtained. The DTS showed predictive validity against response to treatment, as well as being sensitive to treatment effects. The DTS showed good reliability and validity, and offers promised as a scale which is particularly suited to assessing symptom severity, treatment outcome and in screening for the likely diagnosis of PTSD.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
To assess whether vancomycin minimum inhibitory concentration (MIC) creeps among clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in a regional hospital in China. Furthermore, to analyze the causes of vancomycin MIC creeps and the relationship between vancomycin MICs and the outcome among patients with MRSA infection. All clinical isolates of MRSA from 2006-2010 were retrieved and tested by the broth microdilution procedure to determine their vancomycin MIC. Meanwhile, related patient records were analyzed. While all isolates were susceptive to vancomycin, the percentage of isolates with a vancomycin MIC = 1 mg/L increased significantly from 2006 (37.0%) to 2010 (75.7%). Meanwhile, vancomycin usage density (DDDs/1000 bed-days) had increased significantly from 2006-2010. Mean linear correlation analysis showed a statistically significant positive correlation (r = 0.905, P < 0.05) between the consumption of vancomycin and the percentage of MRSA isolates with a vancomycin MIC = 1 mg/L. Clinical records revealed high vancomycin MIC was associated with a higher microbiologic failure rate in MRSA bloodstream infections. The data demonstrated vancomycin MIC creep among clinical isolates in our hospital, and the MIC creep may be caused by the increasing usage of vancomycin. Furthermore, the analysis strongly suggested this shift of vancomycin MIC within the susceptible range may be associated with an increasing probability of treatment failure.
Output: What is MRSA?
Batten disease [juvenile-onset neuronal ceroid lipofuscinosis (JNCL)], the most common progressive encephalopathy of childhood, is caused by mutations in a novel lysosomal membrane protein (CLN3) with unknown function. In this study, we have confirmed the lysosomal localization of the CLN3 protein by immunoelectron microscopy by co-localizing it with soluble and membrane-associated lysosomal proteins. We have analysed the intracellular processing and localization of two mutants, 461-677del, which is present in 85% of CLN3 alleles and causes the classical JNCL, and E295K [corrected], which is a rare missense mutation associated with an atypical form of JNCL. Pulse-chase labelling and immunoprecipitation of the two mutant proteins in COS-1-cells indicated that 461-677del is synthesized as an approximately 24 kDa truncated polypeptide, whereas the maturation of E295K [corrected] resembles that of the wild-type CLN3 polypeptide. Transient expression of the two mutants in BHK cells showed that 461-677del is retained in the endoplasmic reticulum, whereas E295K [corrected] was capable of reaching the lysosomal compartment. The CLN3 polypeptides were expressed further in mouse primary neurons where the wild-type CLN3 protein was localized both in the cell soma and in neuronal extensions, whereas the 461-677del mutant was arrested in the cell soma. Interestingly, co-localization of the wild-type CLN3 and E295K [corrected] proteins with a synaptic vesicle marker indicates that the CLN3 protein might participate in synaptic vesicle transport/transmission. The data presented here provide clear evidence for a cellular distinction between classical and atypical forms of Batten disease both in neural and non-neural cells.
Output: What is the effect of a defective CLN3 gene?
The Titan mine is one of the largest titanium mines in Canada.
Output: The product of Titan mine is what?
The Texans came home in Week 3 to take on the Washington Redskins. In the first quarter, Houston got off to a good start, as TE Mark Bruener caught a 2-yard TD pass. However, the Redskins would tie the game up on a 9-yard run by RB Ladell Betts. From there, things went downhill in the second quarter, as WR Antwaan Randle El caught a 23-yard TD pass and RB Clinton Portis ran 30 yards for a touchdown. In the third quarter, Washington continued to pound Houston, with Portis getting a 1-yard TD run. In the fourth quarter, the Redskins would get one more scoring strike as kicker John Hall kicked a 46-yard field goal. The Texans would get another touchdown, as QB David Carr threw a 2-yard pass to TE Owen Daniels and RB Ron Dayne would run it in for the 2-point conversion. Unfortunately, Houston would fall to 0-3, losing 31-15.
Output: Which team scored first in the game?
NASCAR Thunder 2002 is a racing simulator video game developed by EA Tiburon and published by EA Sports that came out for the Sony PlayStation, Sony PlayStation 2, and Xbox.
Output: Who worked on NASCAR Thunder 2002?
American schools do not have separate classes for boys and girls. If boys want to cook or to sew, they can learn these things in classes that are no longer just for girls. If girls want to repair cars, they can now learn this in school. Most students like to have boys and girls on the same baseball team. Many boys and girls dress alike in school. They were blue jeans and sport shirts. Some have long hair and some have short hair. Sometimes a boy has longer hair than a girl. Even the language is different. Students learn to say fire fighter instead of fireman, police officer instead of policeman, and letter carrier instead of mailman. A person does not need to be a man to fight a fire or to deliver the mail. Most people think that these changes are good. They give all people an equal chance to be happy and to do what they want to do with their lives. Fathers like to tell their sons that they can grow up to be president. Today, mothers can tell the same things to there daughters.
Output: What do most people think of the changes in American schools?
California Jaguars were an American soccer team that played in Salinas, California at the Salinas Sports Complex.
Output: What is the hoe stadium for California Jaguars?
Barbeau Abbey (French: Abbaye de Barbeau or Abbaye Notre-Dame de Barbeau; Latin: Barbelum, Sequanae portus or Sacer portus) is a former Cistercian monastery in Fontaine-le-Port in the Seine-et-Marne department, France.
Output: What group was Barbeau Abbey a member of?
Everyone can reduce their use of energy resources and the pollution the resources cause by conserving energy. Conservation means saving resources by using them more efficiently, using less of them, or not using them at all. You can read below about some of the ways you can conserve energy on the road and in the home. Much of the energy used in the U.S. is used for transportation. You can conserve transportation energy in several ways. For example, you can: plan ahead to avoid unnecessary trips. take public transit such as subways (see Figure 1.1) instead of driving. drive an energy-efficient vehicle when driving is the only way to get there. Q: What are some other ways you could save energy in transportation? A: You could carpool to save transportation energy. Even if you carpool with just one other person, thats one less vehicle on the road. For short trips, you could ride a bike or walk to you destination. The extra exercise is another benefit of using your own muscle power to get where you need to go. Many people waste energy at home, so a lot of energy can be saved there as well. What can you do to conserve energy? You can: turn off lights and unplug appliances and other electrical devices when not in use. use energy-efficient light bulbs and appliances. turn the thermostat down in winter and up in summer. Q: How can you tell which light bulbs and appliances use less energy?
Output: what are two ways that energy can be conserved?
The Girl and the Oak (Serbo-Croatian: Djevojka i hrast) is a 1955 Yugoslav film directed by Kreso Golik.
Output: Under whose direction was The Girl and the Oak produced?
Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes in the chemical structure of synthetic oligonucleotides make them more stable and specific, and new delivery strategies became progressively available. The attention of pharmaceutical industry rapidly turned to RNAi, as an opportunity to explore new drug targets. This review addresses nine small-interfering RNAs (siRNAs) and one unique microRNA (miRNA) inhibitor, which entered the phase 2-3 clinical trials. The siRNAs in focus are PF-04523655, TKM-080301, Atu027, SYL040012, SYL1001, siG12D-LODER (phase 2), QPI-1002, QPI-1007, and patisiran (phase 3). Regarding miRNAs, their content can be down- or up-regulated, by using miRNA inhibitors (AntimiRs) or miRNA mimics. Miravirsen is an AntimiR-122 for hepatitis C virus infection. The flexibility of RNAi technology is easily understood taking into account: (i) the different drug targets (i.e. p53, caspase 2, PKN3, 2-adrenergic receptor, mutated KRAS, microRNAs); (ii) therapeutic conditions, including ophthalmic diseases, kidney injury, amyloidosis, pancreatic cancer, viral hepatitis; and (iii) routes of administration (ocular, intravenous, subcutaneous, intratumoral). Although some issues are still matters of concern (delivery, toxicity, cost, and biological barriers), RNAi definitively opens a wide avenue for drug development.
Output: In November 2017,  in what phase  was  the clinical trial for the drug SYL040012?
In the last few years, several tyrosine kinase inhibitors (TKIs) have been synthesized and become available for preclinical studies and clinical trials. This article summarizes recent achievements in the mechanism of action, pharmacological properties, and clinical activity and toxicity, as well as the emerging role of TKIs in lymphoid malignancies, allergic diseases, and autoimmune disorders. A literature review was conducted of the MEDLINE database PubMed for articles in English. Publications from 2000 through January 2012 were scrutinized. The search terms used were Bruton's tyrosine kinase (Btk) inhibitors, PCI-32765, GDC-0834, LFM-A13, AVL-101, AVL-292, spleen tyrosine kinase (Syk) inhibitors, R343, R406, R112, R788, fostamatinib, BAY-61-3606, C-61, piceatannol, Lyn, imatinib, nilotinib, bafetinib, dasatinib, GDC-0834, PP2, SU6656 in conjunction with lymphoid malignancy, NHL, CLL, autoimmune disease, allergic disease, asthma, and rheumatoid arthritis. Conference proceedings from the previous 5 years of the American Society of Hematology, European Hematology Association, American Society of Clinical Oncology, and ACR/ARHP Annual Scientific Meetings were searched manually. Additional relevant publications were obtained by reviewing the references from the chosen articles. The use of TKIs, especially inhibitors of Btk, Syk, and Lyn, is a promising new strategy for targeted treatment of B-cell lymphoid malignancies, autoimmune disorders and allergic diseases. However, definitive data from ongoing and future clinical trials will aid in better defining the status of TKIs in the treatment of these disorders.
Output: Which enzyme is inhibited by a drug fostamatinib?
Team Services, LLC is a Rockville, Maryland-based sports marketing firm.
Output: What is the city where Team Services, LLC is from?
Blind Willie Walker died in Greenville in 1933 at age 37 of congenital syphilis, which may have been the reason for his blindness.
Output: What was the cause of death for Blind Willie Walker?
Love is a telephone which always keeps silent when you are longing for a call, but rings when you are not ready for it. As a result, we often miss the sweetness from the other end. Love is a telephone which is seldom program-controlled or directly dialed. You cannot get an immediate answer by a mere "hello", let alone go deep into your lover's heart by one call. Usually it had to be relayed by an operator, and you have to be patient in waiting. _ Love is a telephone which is always busy, When you are ready to die for love, you only find, to your disappointment, the line is already occupied by someone else, and you are greeted only by a busy line. This is an eternal regret handed down from generation to generation and you are only one of those who languish for(...) followers. Love is telephone, but it is difficult to seize the center time for dialing, and you will let the opportunity slip if your call is either too early or too late. Love is a telephone which is not always associated with happiness. Honeyed words are transmitted by sound waves, but when the lovers are brought together, the phone serves no purpose that many lovers observe that marriage is the _ of love. Love is a telephone which, when you use it for the first time, makes you so nervous and excited that you either hold the receiver upside down or dial the wrong number. By the time you've calmed down, you will beat a loss to whom you should make the call. Love is a telephone which often has crossed lines. And this usually happens to you unexpectedly. Your time will either cross or be crossed. Both cases are referred to as "triangle". Fortunately, all such occurrences are transient .
Output: What is the best title of the passage?
Two spontaneous mutant beige rats, with phenotypes resembling human Chediak- Higashi syndrome (CHS), were found independently in two inbred strains. Both beige mutations were identified to be recessive alleles in the Lyst locus on rat chromosome 17 and the alleles were denoted Lyst(bg) and Lyst(bg-Kyo). As it is almost impossible to discriminate these mutations phenotypically, we developed an allele-specific genotyping method for the Lyst gene. The nested PCR amplification was followed by restriction fragment length polymorphism (RFLP) analysis. By this method, we could discriminate the mutant Lyst(bg), Lyst(bg-Kyo) alleles, and the normal Lyst allele, easily and accurately.
Output: Which syndrome is associated with mutations in the LYST gene?
Coming off a bye week, the Bears battled rival Detroit Lions on Monday Night Football. The team kept the Lions from scoring until the fourth quarter, and forced four takeaways. The first turnover forced was in the first half, when Lance Briggs stripped the ball from Mikel Leshoure, which was recovered by Julius Peppers. The second and third turnovers were forced in the third quarter on Zack Bowman's muffed punt recovery, and Brian Urlacher recovering Joique Bell's fumble. The final turnover occurred when Lions quarterback Matthew Stafford's pass was intercepted by D. J. Moore. The Bears struck first on Jay Cutler's touchdown pass to Brandon Marshall, and Robbie Gould kicked a field goal to increase the first half score to 10-0. During the game, Lions defensive tackle Ndamukong Suh threw Cutler to the ground, injuring his ribs. Cutler was eventually replaced by Jason Campbell for a play, before returning to the game. In the second half, Gould kicked another field goal, and prevented the Lions from scoring until the final 36 seconds of the game, when Stafford threw a 12-yard touchdown pass to Ryan Broyles to narrow the margin to six points, but the Bears sealed the victory by recovering the ensuring onside kick.
Output: Which team scored first?
The Peasant revolt in Flanders 1323-1328 was a popular revolt in late medieval Europe. Beginning as a series of scattered rural riots in late 1323, peasant insurrection escalated into a full-scale rebellion that dominated public affairs in Flanders for nearly five years until 1328. The uprising in Flanders was caused by both excessive taxations levied by the Count of Flanders Louis I, and by his pro-French policies. The insurrection had urban leaders and rural factions which took over most of Flanders by 1325. The revolt was led by Nicolaas Zannekin, a rich farmer from Lampernisse. Zannekin and his men captured the towns of Nieuwpoort, Veurne, Ypres and Kortrijk. In Kortrijk, Zannekin was able to capture the count himself. In 1325, attempts to capture Gent and Oudenaarde failed. The King of France, Charles IV intervened, whereupon Louis was released from captivity in February 1326 and the Peace of Arques was sealed. The peace soon failed, and the count fled to France when more hostilities erupted. Louis convinced his new liege Philip VI of France to come to his aid, and Zannekin and his adherents were decisively defeated by the French royal army in the Battle of Cassel.
Output: What event happened first, Louis being released from capitivity, or the insurrection that had urban leaders and rural factions which took over most of Flanders?
The dodo is among the most famous extinct creatures, and _ for human-caused extinction events. Despite its bad name, and the fact that the species was alive during recorded human history, little is actually known about how this animal lived, looked, and behaved. A new study of the only known complete skeleton from a single bird takes advantage of modern 3-D laser scanning technology to open a new window into the life of this famous extinct bird. The study was presented at the 74th Annual Meeting of the Society of Vertebrate Paleontology in Estrel, Berlin. Leon Claessens, Associate Professor at the College of the Holy Cross, and lead researcher on the study said that, "the 3-D laser surface scans we made of the fragile dodo skeletons enable us to reconstruct how the dodo walked, moved and lived to a level of detail that has never been possible before. There are so many outstanding questions about the dodo bird that we can answer with this new knowledge." A complete dodo skeleton, found by an amateur collector and barber, Etienne Thirioux, on the island of Mauritius between 1899 and 1917, has remained unstudied, even though it is the only complete dodo skeleton from a single individual bird known to exist. All other skeletons are incomplete combinations, meaning that they are gathered from more than one individual. In addition, Thirioux constructed a second, partially combined skeleton, which contains many bones that also belong to a single bird. "Being able to examine the skeleton of a single, individual dodo, which is not made up from as many individual birds as there are bones, as is the case in all those other combined skeletons, truly allows us to appreciate the way the dodo looked and see how tall or fat it really was," said Juilan Hume, of the Natural History Museum UK, a co-author on the study. The scans were performed on site in Durban, South Africa, and allow examination of the biology of this mysterious extinct bird in detail for the first time. Using the newest digital tools and techniques, the scans provide an insight into how the flightless dodo may have developed its giant size, and how it walked and lived in its forest home. According to Kenneth Rijsdijk, a biologist from University of Amsterdam, "the skull of the dodo is so large and its mouth so strong that it is easy to understand that the earliest naturalists thought it was related to sharks and other birds of prey , rather than the pigeon family."
Output: What is special about the dodo skeleton found by an amateur collector?
Researchers may tell us that spending money on experiences produces more happiness than spending money on things. Going to a bar with friends is always pleasurable in slightly different ways. However, on the other hand, a table may also give us lots of positive experiences sometimes. I just moved from New York City to suburban Pennsylvania, It's been quite a change of pace, with some positives and negatives, One of the best parts is that I'm spending more time outside. I quite enjoy staying outside, especially eating outside. I had a goal to eat outside as often as possible this summer, so one of my first purchases for the new house was a table and a set of chairs for the yard. Is my yard table a thing or an experience? It's clearly a thing and yet it enables the experience of eating outside. I love eating outside, and so my yard table is one of my favorite purchases, ever. Therefore I find the dividing line between things and experiences is more nuanced than at first glance. However, to be happy, the most important thing is what kind of purchases you have made. Sometimes we may all have purchases that seem like a waste of money like probably half the clothes in our closets, but how does this happen?' There are many reasons for why this happens. The biggest is that we spend a lot of our time working to earn money to buy things. The problem is that we buy a lot of stuff that we don't actually need. There's nothing worse than looking in your closet and realizing how many hours you spent laboring to buy things you never wear. But how about a table that lets you enjoy being outside in the summer? That's worth every minute and penny and from it you will also get more happiness.
Output: Which one is an example of spending money on experiences?
MicroRNAs (miRNAs) regulate many biological processes such as development, metabolism, and others. They are processed from their primary transcripts called primary miRNA transcripts (pri-miRNAs) by the processor complex containing the RNAse III enzyme, DICER-LIKE1 (DCL1), in plants. Consequently, miRNA biogenesis is controlled through altering pri-miRNA accumulation and processing, which is crucial for plant development and adaptation to environmental changes. Plant pri-miRNAs are transcribed by DNA-dependent RNA polymerase II (Pol II) and their levels are determined through transcription and degradation, whereas pri-miRNA processing is affected by its structure, splicing, alternative splicing, loading to the processor and the processor activity, which involve in many accessory proteins. Here, we summarize recent progresses related to pri-miRNA transcription, stability, and processing in plants.
Output: Which polymerase transcribes pri-miRNAs?
The Palace of Nations (French: Palais des Nations, pronounced: (pal de nsj)) in Geneva, Switzerland, was built between 1929 and 1938 to serve as the headquarters of the League of Nations.
Output: What year was Palace of Nations opened?
Edificio La Nacional is an Art Deco office building located in Avenida Juarez, in the Historical Centre of Mexico City, just across the street from Palacio de Bellas Artes.The building's architect was Manuel Ortiz Monasterio.
Output: Which is the kind of art style of Edificio La Nacional?
Olaf Gudrdsson, or as he was named after his death Olaf Geirstad-Alf, was a legendary Norwegian king of the House of Yngling from the Ynglinga saga.
Output: What noble family was Olaf Geirstad-Alf part of?
It seems that the Great Wall is the place to rock . There will be two parties held on the Great Wall this month. Great Wall I The latest Great Wall party is sponsored by the Club and Elektrobeat and held at Jinshanling. Local DJ Mark, as well as guests Slab from Australia, Usami and Bobby from Hong Kong will sing at the party. All drinks are priced at 20 yuan($ 2.4). Tickets: 200yuan($ 24), including bus ride there and back plus entrance fee to the Great Wall. T/D: 8p.m. to 2 a.m., Sept. 20. Pre-sale tickets are to be booked at: Public Space: 6416-0759; Neo Lounge: 6416-1077. Buses: Leave at 5 p.m. on Saturday, Sept. 20 from Neo Lounge, 99 Xinfuncun Zhonglu, Sanlitun, Chaoyang District. For more info: www. elektrobeat. com Great wall II The other party at the end of this month at Jinshanling will be started with live performances by Askar, Brain Failure, Longkuan, Supermarket, Mr. Zhou, Beijing Talking and the Yi band. Dance till dawn to the wonderful sounds of DJs Ben, Mickey Zhang, Will, Cheese, Gao Hu and Huang Weiwei. T/D: 8 p.m. to 2 a.m., Sept. 27. Tickets: 350 yuan ($ 42) or 300 yuan ($ 36) for groups of 10 or more, 500 yuan ($ 60) at the door and VIP tickets 800 yuan ($ 72), transportation included. Buses: Depart from the north gate of Wbrkers' Stadium at noon, 2 p.m., 4 p.m., Sept. 27. For more info: contact Li Zhenhua at lah@msgp. Org or call 133-2119-1731.
Output: What day of the week is September 27?
The Royal Mint has chosen Beatrix Potter's thieving Peter Rabbit as the first character from children's literature ever to appear on a UK coin. Peter, pictured in the blue jacket that he is forced to abandon in the garden of Mr McGregor when he is caught stealing vegetables, is captured on a special, coloured edition of a 50p coin available from now. The Royal Mint, which described Peter as "the most recognizable of Potter's creations, and one of the most cherished from children's literature", will release uncoloured versions of the coin in change later this year. Three more of Potter's characters will also be committed to currency later this year, as part of celebrations marking 150 years since the children's author's birth. The images have been created by coin designer Emma Noble, who said it was "amazing to be given the opportunity to work with such famous and treasured literary characters". Potter's The Tale of Peter Rabbit, featuring Peter and his better-behaved siblings Flopsy, Mopsy and Cottontail, was the first of her stories to be published, released in 1902 by Frederick Warne & Co. Potter would go on to follow it with a series of much-loved stories which remain popular today, from The Tale of Squirrel Nutkin to The Tale of Jemima Puddle-Duck.
Output: Which character from children's literature can be found on the UK coin?
Chronic myelogenous leukemia is characterized by the Philadelphia-chromosome, a shortened chromosome 22 which is the result of a reciprocal translocation between chromosome 9 and 22. The fusion gene is called BCR-ABL. After transcription and translation the constitutively activated p210 BCR-ABL oncoprotein is formed. This leads to uncontrolled activation of the ABL tyrosin kinase. Deregulated cellular proliferation and diminished apoptosis of BCR-ABL transformed cells is the result. Expression of the BCR-ABL oncoprotein is sufficient and necessary for the development of a CML phenotype. Imatinib mesylate (Glivec) is a small molecule that binds to the ATP pocket of ABL and blocks downstream signalling events. Imatinib is very effective in the treatment of CML in all stages of the disease. Patients with newly diagnosed chronic phase CML were randomized to imatinib or to interferon plus cytarabine in the IRIS trial. Imatinib showed significantly superior tolerability, hematologic and cytogenetic resposes and increased time to progression. In patients with advanced phase CML, imatinib is less effective and response duration is short. Median overall survival of blast crisis patients is 6.9 months only. Additional BCR-ABL independent chromosomal abnormalities are common in advanced phase CML and result in resistance to imatinib. BCR-ABL kinase-domaine mutations are frequently found in imatinib resistant patients and confer diminished sensitivity to imatinib. Second generation, more powerful ABL kinase inhibitors, which are effective against most of the known mutations are currently tested in clinical trials.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
The point was named Gossard perspector by John Conway in 1998 in honour of Harry Clinton Gossard who discovered its existence in 1916.
Output: When was Gossard perspector found or made?
A study suggests that although most students at UK universities are happy with their courses, dissatisfaction has grown as fees rise.The study highlights a big variation in teaching time, and lists different ideas about the value of getting university degrees. Katharine Collins, a second-year college student The course has been very interesting, but I was expecting a little more one-to-one time with my teacher. We do about four assignments each term, each of which is about 3,000 words.However, sometimes they are not that helpful.We hope to be given the right to write feedback after every assignment, but we had no feedback at all throughout the first year.We are given grades about three weeks after we hand the assignments in.There is no feedback on where we have gone wrong or how we might improve. Lee Millington, a creative-writing student I choose the courses because of its reputation.There is a lack of one-to-one teaching.I would like personalized feedback from an expert in my field of writing.Some of the lectures have been quite helpful but they try to use too many different styles of writing.For example, if you want to be a poet, you might find that the lectures focus too much on novels. I think there is too much attention paid to sharing our work in workshops and giving each other feedback.I think there should be more time given to actual teaching, rather than to feedback from people who are at a similar level to me. Reporters from Hounsdown Secondary School, Ella, 16 When I work independently, I feel I have more freedom to develop my ideas and come up with more original viewpoints.The price of university will still be worth it to get the qualifications necessary for better jobs. Tyier, 16 Although the cost of university is very high now, I think university is required for gaining a good and well-paid job. Agencies
Output: Who will most tend to be a professional novelist among the students mentioned in the passage?
The mechanism of action, pharmacokinetics, and use of flumazenil in benzodiazepine overdose, as well as in the management of other disease states, are reviewed. Flumazenil interacts at the central benzodiazepine receptor to antagonize or reverse the behavioral, neurologic, and electrophysiologic effects of benzodiazepine agonists and inverse agonists. Flumazenil has been studied for a variety of indications, including as an antidote to benzodiazepine overdose and for awakening of comatose patients, reversal of sedation after surgery and in critically ill patients, and management of hepatic encephalopathy. It improves the level of consciousness in patients with benzodiazepine overdose; however, resedation may occur within one to two hours after administration, so repeated doses or a continuous infusion may be required to maintain therapeutic efficacy. It appears to be effective in reversing sedation induced by midazolam or diazepam, and case reports suggest that it is useful in awakening comatose patients, although its clinical utility is questionable. Flumazenil has proved useful in reversing conscious sedation in critically ill patients, although response may be dose dependent. Animal models indicate that flumazenil is of some benefit in hepatic encephalopathy, but until well-designed clinical trials are conducted, hepatic encephalopathy must be considered an investigational indication for flumazenil. Adverse reactions include CNS manifestations, resedation, cardiovascular effects, seizures, and alterations in intracranial pressure and cerebral perfusion pressure. Hepatic dysfunction results in a substantial change in the pharmacokinetic profile of flumazenil; therefore, dosage adjustment may be necessary in patients with hepatic dysfunction or in those receiving medications that alter flumazenil metabolism. Flumazenil has been shown to reverse sedation caused by intoxication with benzodiazepines alone or benzodiazepines in combination with other agents, but it should not be used when cyclic antidepressant intoxication is suspected. It may be beneficial after surgery when benzodiazepines have been used as part of anesthesia and after a diagnostic or surgical procedure when assessment of CNS function is necessary.
Output: Which drug should be used as an antidote in benzodiazepine overdose?
The Rio Grande rises from south-central Colorado in the United States and flows to the Gulf of Mexico.
Output: What body of water does Rio Grande join?
Bleu du Vercors-Sassenage is a mild pasteurized natural rind cow's milk blue cheese originally produced by monks in the Rhone-Alpes region of France in the 14th century.
Output: What material was used for Bleu du Vercors-Sassenage?
Armstrong Siddeley was merged with the aircraft engine business of Bristol Aeroplane Company (Bristol Aero Engines) to form Bristol Siddeley as part of an ongoing rationalisation under government influence of the British aircraft and aircraft engine manufacturers.
Output: What was replaced Armstrong Siddeley?
Facioscapulohumeral muscular dystrophy (FSHD), the most prevalent myopathy afflicting both children and adults, is predominantly associated with contractions in the 4q35-localized macrosatellite D4Z4 repeat array. Recent studies have proposed that FSHD pathology is caused by the misexpression of the DUX4 (double homeobox 4) gene resulting in production of a pathogenic protein, DUX4-FL, which has been detected in FSHD, but not in unaffected control myogenic cells and muscle tissue. Here, we report the analysis of DUX4 mRNA and protein expression in a much larger collection of myogenic cells and muscle biopsies derived from biceps and deltoid muscles of FSHD affected subjects and their unaffected first-degree relatives. We confirmed that stable DUX4-fl mRNA and protein were expressed in myogenic cells and muscle tissues derived from FSHD affected subjects, including several genetically diagnosed adult FSHD subjects yet to show clinical manifestations of the disease in the assayed muscles. In addition, we report DUX4-fl mRNA and protein expression in muscle biopsies and myogenic cells from genetically unaffected relatives of the FSHD subjects, although at a significantly lower frequency. These results establish that DUX4-fl expression per se is not sufficient for FSHD muscle pathology and indicate that quantitative modifiers of DUX4-fl expression and/or function and family genetic background are determinants of FSHD muscle disease progression.
Output: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
Zach Conroy and Celeste Mercier are the hottest couple on and off the ice until a nasty spill knocks Celeste out of competition. With their dreams of gold medals put in ice and their romance chilling as a result, Zach has to find another partner for the championship in Paris. And fast. In glides Alejandra Alex Delgado, a beautiful, tough talking hockey player with fierce moves and a fearless skating style. Zachs willing to give her a chance, but his coach, Bryan quits in a huff to train Zachs biggest rivals, Cindy Halgyord and Jason Bright. That leaves Zach with a newbie partner and no coach until he convinces former figure skating champ Jackie Dorsey to step in. She puts Zach and Alex through their paces, but the hardest trick of all is keeping them focused on practice and not each other as they bicker and struggle with a growing attraction both on and off the ice. Jackie knows these kids are fire and ice, and sees the chemistry between them. She also knows that if they cant get it together, theyll set the skating world on fire. That is, if the heat between them doesnt cause a total meltdown. With the competition fierce and the stakes higher than ever, the only way Zach and Alex can win is by putting aside their feelings and pulling out a secret weapon: the deadly Pamchecko jump. But is it worth the risk? Can Zach rise above the past and his history of injuring partners? And can Alex prove that shes got the moves to match her passion? It all comes down to the biggest moment of their lives when they learn that sometimes on the ice and in life youve got to risk it all.
Output: Who refuses to coach the pair?
The 10th Cavalry returned from the Philippines in late 1902 and settled down in different posts in the south western United States. Patrols and garrison life was the routine for the regiment. Under war plans, the 10th was designated for service in the Pacific and support in the Philippines from 1915 through 1942 but never rotated there. The 9th Cavalry Regiment became "Park Rangers" in 1905 for Yosemite National Park and other state and federal lands. The Troopers' Campaign Hat, sporting the "Montana Pinch" used to help shed the tropical downpours. That "Montana Pinch" gave the hat the distinctive look we recognize today as the "Smokey Bear Hat".
Output: Which regiment did not create the Montana pinch hat, 9th or 10th?
In his will, Sugarman provided for the establishment of The George Sugarman Foundation, Inc. A 1934 graduate of the City College of New York, Sugarman served in the United States Navy from 1941 to 1945, assigned to the Pacific theater.
Output: What is the name university that educated George Sugarman?
Fevansia is a fungal genus in the family Albatrellaceae.
Output: Is the taxon rank of Fevansia species or genus?
Riseberga Abbey (Swedish: Riseberga kloster), was a Cistercian nunnery in Sweden, in operation from cirka 1180 until 1534.
Output: What year did Riseberga Abbey dissolve?
zfhz1b is the causative gene for Mowat-Wilson syndrome, in which patients demonstrate developmental delay and Hirschsprung disease, as well as other anomalies. We identified a patient with Mowat-Wilson syndrome who also developed cholestasis and histopathologic features consistent with biliary atresia, suggesting that mutations involving zfhz1b may lead to biliary developmental anomalies or injury to the biliary tract. We used the zebrafish model system to determine whether zfhx1b has a role in vertebrate biliary development. Using zebrafish we determined that zfhx1b was expressed in the developing liver during biliary growth and remodeling, and that morpholino antisense oligonucleotide-mediated knockdown of zfhx1b led to defects in biliary development. These findings were associated with decreased expression of vhnf1, a transcription factor known to be important in biliary development in zebrafish and in mammals. Our studies underscore the importance of genetic contributions in the etiology of infantile hepatobiliary disorders, including biliary atresia.
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
John Hsu is the Old Dominion Foundation Professor of Music, emeritus, at Cornell University, where he taught for 50 years, from 1955 until his retirement in 2005.
Output: What is John Hsu's place of employment?
We evaluated the adherence and acceptability of a vaginal ring containing dapivirine, maraviroc, or both drugs for 28days during a Phase I placebo-controlled trial in 48 HIV-negative sexually abstinent U.S. women aged 18-40. Adherence was assessed weekly by clinical interview and computer-assisted self-interviewing; acceptability assessment occurred at the last product-use visit. Study retention was 98% (47/48); 94% (45/48) reported being fully adherent with ring use during the 28-day period. Two participants experienced the ring partially coming out. Analysis was blinded and behavioral data were combined across study groups. Most women reported being very comfortable having the ring in their vagina; 44% preferred continuous use, whereas 51% had no preference compared to episodic use. Although a range of minor ring concerns were expressed, few were actually experienced. High adherence to and acceptability of this vaginal ring in this Phase I trial contributes to its promise as a sustained mechanism for multidrug vaginal microbicide delivery.
Output: Which infection can be prevented with Dapivirine?
"Selfie" joins ranks of dictionary words. In 2002, an Australian man went to his friend's 21st birthday party. He got drunk, _ on some steps and cut his lip. He took a picture of his injuries and shared it with his friends on an online forum. "And sorry about the focus," he wrote, "it was a selfie." That was the first recorded use of the word "selfie", according to linguistic experts at Oxford Dictionaries. On Nov 19, Oxford Dictionaries declared "selfie" Word of the Year for 2013, in honor of the term having taken over the world thanks to millions of smart phone self-portraits and the resulting shares on social media. So what does the choice of the word say about our culture? Mary Elizabeth Williams, writing in Salon magazine, says the word reminds us that contemporary culture is defined by our narcissism .Megan Jackson from a local newspaper points out a selfie may only focus on appearance. Selfies invite judgment based on appearance alone. What kind of cultural influence does this have on women? Erin Gloria Ryan on Jezebel says selfies teach young woman to obsess over their appearance and judge themselves on the basis of beauty rather than accomplishments. "They're a reflection of the warped way we teach girls to see themselves as decorative," said Ryan. In Slate magazine, Rachel Simmons has the opposite view. She argues that selfies are an example of young women promoting themselves and taking control of their own self-presentation. Think of each one, she says, as "a tiny pulse of girl pride --a shout-out to the self".
Output: Who holds a positive opinion towards selfie in the life of women?
With the first Klingon-centric story in The Next Generation, the first season episode ''Heart of Glory'', the Klingons once again became an important part of the Star Trek universe, and by the advent of the series Star Trek:
Output: Which fictional universe is Klingon from?
ATP13A2 (PARK9) loss of function mutations are a genetic cause of an early-onset form of Parkinson's disease (PD), with in vitro studies showing that ATP13A2 deficits lead to lysosomal and mitochondrial dysfunction and -synuclein accumulation, while elevated ATP13A2 expression reduces -synuclein toxicity. The three human brain tissue studies assessing changes in ATP13A2 expression in PD produced divergent results; mRNA is increased while protein levels were observed to be either increased or decreased. This apparent conflict in protein levels might have arisen from examining Lewy body disease cases with coexisting Alzheimer-type pathologies.To assess whether ATP13A2 levels in Lewy body disease are modified by Alzheimer-type -amyloid deposition, we evaluated cases of pure PD and pure dementia with Lewy bodies (DLB) for changes in ATP13A2, -synuclein and -amyloid protein levels in cortical regions with and without Lewy bodies. In all Lewy body disease cases, we identified decreased ATP13A2 protein levels that correlated with increases in both -synuclein and -amyloid. Partial colocalization was observed between ATP13A2 and -synuclein in Lewy bodies, whereas ATP13A2 did not colocalize with pathological -amyloid deposition. Our data show that patients with Lewy body diseases have an overall deficit in ATP13A2 protein levels, with the remaining protein being more insoluble and partially redistributing towards Lewy bodies. This supports the concept that increasing ATP13A2 levels may offer potential therapeutic benefits to patients with Lewy body diseases.
Output: Which is the primary protein component of Lewy bodies?
As a result of continued decline in the traditional Gaelic heartlands, today no Civil parishes in Scotland in Scotland has a proportion of Gaelic speakers greater than 65% (the highest value is in Barvas, Isle of Lewis, with 64.1%). In addition, no civil parish on mainland Scotland has a proportion of Gaelic speakers greater than 20% (the highest value is in Ardnamurchan, Highland (council area), with 19.3%). Out of a total of 871 civil parishes in Scotland, the proportion of Gaelic speakers exceeds 50% in 7 parishes, exceeds 25% in 14 parishes, and exceeds 10% in 35 parishes. Decline in traditional areas has recently been balanced by growth in the Scottish Lowlands. Between the 2001 and 2011 censuses, the number of Gaelic speakers rose in nineteen of the countrys 32 council areas. The largest absolute gains were in Aberdeenshire (council area) (+526), North Lanarkshire (+305), City of Aberdeen (+216), and East Ayrshire (+208). The largest relative gains were in Aberdeenshire (+0.19%), East Ayrshire (+0.18%), Moray (+0.16%), and Orkney Islands (+0.13%).
Output: Which area saw a larger gain in Gaelic speakers, North Lanarkshire or East Ayrshire?
Phthiriasis palpebrarum is an uncommon cause of blepharoconjunctivitis in which Pthirus pubis infest the eyelashes. We report a case of unilateral phthiriasis palpebrarum with crab louse. A 45-year-old man presented with conjunctival hyperaemia and moderate itching associated with irritation, and crusty excretions of the eyelashes in the left eye. Careful slit-lamp examination revealed many lice and nits in left eye and mild conjunctival hyperaemia. No abnormality was found in the right eye. On dermatologic examination, only one louse was found at the pubic area. The patient was treated effectively with petrolatum jelly (Vaseline) and 1% permethrin shampoo (Kwellada 1% shampoo). At the end of the first week no louse or nit was present on eyelashes and pubic area.
Output: What is the cause of Phthiriasis Palpebrarum?
The Honourable Gerald David Lascelles (21 August 1924 -- 27 February 1998) was the younger son of Henry Lascelles, 6th Earl of Harewood and Mary, Princess Royal, the only daughter of King George V of the United Kingdom and Mary of Teck.
Output: Who is Gerald David Lascelles's dad?