niryuu/sni-each-converted huggingface dataset:
The article briefly summarizes the milestones leading to current knowledge and the possibility of treating one of the most widespread and perhaps least known diseases, restless legs syndrome (RLS). Until the mid-twentieth century, the syndrome first described by Willis (1685), was sporadically reported in medical literature and in most cases deemed a bizzare condition. It was only with Ekbom's detailed clinical description of the syndrome (1944) and the polygraphic recordings of Coccagna et al. (1962) that RLS became well-recognised clinical entity. Since then, almost all sleep laboratories have devoted much of their research to discovering the pathogenetic mechanisms underlying the disease and devise increasingly specific treatment. Major advances have been made in recent years, but a full understanding of RLS is still a long way off.
Output: Willis-Ekbom disease is also known as?
7,8-Dihydro-8-oxoguanine (8-oxoG) is the most frequent mutagenic lesion caused by oxidative stress. Eukaryotic cells use a specific DNA glycosylase, OGG1, to excise 8-oxoG from DNA. The mild phenotype of OGG1 null mice has been attributed to the existence of alternative pathways, including Cockayne syndrome B (CSB)-dependent transcription coupled repair (TCR), for removal of 8-oxoG. We have studied repair and transcription activities at 8-oxoG lesions with a reconstituted transcription system (RTS; RNA polymerase II, TBP, TFIIA, TFIIB, TFIIE, TFIIF and TFIIH), as well as in cellular extracts and in vivo. All measurable repair activity at 8-oxoG lesions takes place in the 3'-direction from the lesion, indicating base excision repair (BER) activity and negligible role of nucleotide excision repair (NER). Although 8-oxoG has been shown to be preferentially removed from the transcribed strand, in vitro experiments with purified transcription factors failed to identify a definite block for RNA polymerase II at the lesion. However, a weak block was observed at the lesion during transcription carried out with RTS as well as with cellular extracts. RNA polymerase II was identified at the site of the lesion on obstructed templates. Wild-type cells, as well as cells carrying targeted mutations of genes required for removal of 8-oxoG, were transfected with a luciferase expression vector containing an 8-oxoG lesion. No significant obstruction at 8-oxoG lesions was observed by this in vivo approach. In control experiments transcription elongation was completely blocked by cisplatin.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
Peripheral neuropathy (PN) has been reported in idiopathic and hereditary forms of parkinsonism, but the pathogenic mechanisms are unclear and likely heterogeneous. Levodopa-induced vitamin B12 deficiency has been discussed as a causal factor of PN in idiopathic Parkinson's disease, but peripheral nervous system involvement might also be a consequence of the underlying neurodegenerative process. Occurrence of PN with parkinsonism has been associated with a panel of mitochondrial cytopathies, more frequently related to a nuclear gene defect and mainly polymerase gamma (POLG1) gene. Parkin (PARK2) gene mutations are responsible for juvenile parkinsonism, and possible peripheral nervous system involvement has been reported. Rarely, an association of parkinsonism with PN may be encountered in other neurodegenerative diseases such as fragile X-associated tremor and ataxia syndrome related to premutation CGG repeat expansion in the fragile X mental retardation (FMR1) gene, Machado-Joseph disease related to an abnormal CAG repeat expansion in ataxin-3 (ATXN3) gene, Kufor-Rakeb syndrome caused by mutations in ATP13A2 gene, or in hereditary systemic disorders such as Gaucher disease due to mutations in the -glucocerebrosidase (GBA) gene and Chediak-Higashi syndrome due to LYST gene mutations. This article reviews conditions in which PN may coexist with parkinsonism.
Output: Which syndrome is associated with mutations in the LYST gene?
The days of the sneak thief who stole a couple of apples or a packet of sweets from a chain store are actually over. I had a chance to say this to a young offender the other day, "Sweets from a chain store?" He said, "You must be joking. That's what kids do." I may add that he was aged 11. In other words, today's young criminals would find it laughable to risk being caught for petty theft of this description. They've got enough money in their pockets to buy the sweets they want, anyway. I think it's all too easy to put the blame on anyone but ourselves. Faced as they are with a society that frequently gives them up on the grounds of color1, race or low learning ability, these children turn to crime as a means of showing off their self-respect. Nurtured on films and TV glamorizing the role of the criminal, they are quick to copy these anti-heroes. It is a matter of increasing concern to the police and government that the Children and Young Persons Act, 1969, is becoming improper to deal with the rise in young criminals. Because the emphasis has been placed on the cause and gentle treatment of their crimes, rather than on old-fashioned methods of punishment, the children themselves know well that there is very little that can be done to prevent them continuing to steal, damage and in some case even cause the death of those they choose to terrorize . I don't like the look of this situation any more than you do. In our own interests and in those of our children and grandchildren, we cannot continue to take the "it's nothing to do with me" attitude we have used for so long. We must unite in a common demand for harder and stricter methods against these young criminals.
Output: In the writer's opinion, who should be blamed most?
BEIJING - Astronomers have defended against rumors that the terrible earthquake and the following tsunami in Japan were closely related to or even caused by the "supermoon" that will appear in the sky on Saturday. The word "supermoon" was introduced in a report by the British newspaper Daily Mail on March 9, which said amateur scientists were warning that such an astronomical phenomenon could disturb the Earth's climate patterns and may even cause earthquakes and volcanic activity. The moon will be 356,577 kilometers from the Earth on Saturday, the closest in 19 years, and the closest point in its oval orbit coincides with a full moon, the report said. However, Saturday's moon is not actually the closest to Earth in 19 years, Tang Haiming, an astronomer with Shanghai Astronomical Observatory under the Chinese Academy of Sciences, told Xinhua News Agency. A shorter distance of 356,570 km between the two bodies was reached in January 2005, and a distance of 356,566 km was seen in December 2008. Yet some people suggest that previous supermoons have occurred prior to extreme weather events. In 1974 the phenomenon was followed by Cyclone Tracy in Darwin, Australia, and in 2005 it occurred shortly before a deadly tsunami in Indonesia. Coincidentally, two fresh disasters happened in Asia right before Saturday's supermoon. The public's concern about their connection with the moon boomed after Japan's terrible earthquake and tsunami and an earthquake in Southwest China's Yunnan province that killed 25 people on March 10. But astronomers are trying to _ people that such rumors are merely unreasonable. "A supermoon could cause high tides but has no direct relation with natural disasters such as earthquakes," Liu Jie, a researcher with the China Earthquake Network Center, told China Daily on Tuesday. "We can't find any necessary connection between previous supermoons and earthquakes. And the quake in Japan occurred because the Earth's inner energy had accumulated to some extent, and it's not related to the moon. " he said. James Garvin, chief scientist at the Goddard Space Flight Center under NASA, said in an article on NASA's website that "the effects on Earth from a supermoon are minor.""The combination of the moon being at its closest to Earth in its orbit, and being in its 'full moon' configuration ( to the Earth and sun), should not affect the inner energy balance of the Earth, since there are lunar tides every day. " Zhu Jin, curator of the Beijing Planetarium, said"the moon moves around the earth in a certain path, so each orbit has a perigee - its closest approach, and an apogee - its furthest distance.""A lunar perigee occurs once a month and there are very small differences in distances between perigees,"he said."Those tiny differences are far from enough to cause earthquakes or eruption of a volcano,"he added.
Output: What's the real reason for the quake in Japan?
#United States Capitol It serves as the seat of government for the US Congress. It is located in Washington, D. C., on top of Capitol Hill at the eastern end of the National Mall. Officially, both the east and west sides of the Capitol are referred to as "fronts". Historically, however, the east front was initially the side of the building intended for the arrival of visitors and famous guests. Phone: (202) 225-6827 Official website: www.aoc.gov Hours: Monday-Saturday: 9:00 a.m.-4:30 p.m. #International Spy Museum It is a privately owned museum dedicated to the field of espionage located in Washington. D. C., The museum was built by The Malrite Company at a cost of US $ 40 million. Despite being one of the few museums in Washington that charges admission fees, it has been popular since its opening in July 2002. Phone: (202) 393-7798 Official website: www.spymuseum.org Hours: Monday-Sunday: 9:30 a.m.-6:00 p.m. #National Museum of Natural History It is a natural history museum administered by the Smithsonian Institution, located on the National Mall in Washington, D.C., Admission is free and the museum is open 364 days a year. The museum's collections total over 125 million specimens of plants, animals, fossils, minerals, rocks, meteorites ,and human cultural artifacts, making it the largest such museum anywhere. It is the second most popular of all of the Smithsonian museums and is also home to about 185 professional natural history scientists--the largest group of scientists dedicated to the study of the natural and cultural history in the world. Phone: (202) 633-1000 Official website: www.mnh.si.edu #Jefferson Memorial It is a presidential memorial in Washington, D. C., dedicated to Thomas Jefferson, an American Founding Father and the third president of the United States. The neoclassical building was designed by John Russell Pope. It was built by Philadelphia contractor John Mc. Shain. Construction began in 1939, the building was completed in 1942, and the bronze statue of Jefferson was added in 1947. When completed, the memorial occupied one of the last significant sites left in the city. Phone: (202) 426-6821 Official website: www.mps.gov/thje
Output: Which admission is free?
Boris Babacar Diaw-Riffiod, better known as Boris Diaw (born April 16, 1982), is a French professional basketball player for the San Antonio Spurs of the National Basketball Association (NBA).
Output: What is the name of Boris Diaw's team?
CBSN is an internet television news channel operated by the CBS News and CBS Interactive divisions of CBS Corporation which launched on November 6, 2014.
Output: Which industry is CBSN associated with?
Her mother was The Noble Consort (Chao Chom Manda) Saeng Galyanamitra (daughter of Phraya Jayavichit, son of Chao Phraya Nikara Bodindra (Toh) who built Galyanamitra Temple. Princess Charoensri Chanamayu had 3 siblings; 2 elder brothers and 1 younger sister; Prince Isaravongs Vorarajakumara (4 September 1870 -- 5 June 1872) Prince Nabhanka Nibandhabongs (8 August 1874 -- 17 September 1876) Princess Charoensri Chanamayu (31 March 1878 -- 24 December 1916) Princess Beatrice Bhadrayuvadi died on 30 September 1913, at the age of only 36.
Output: Who is Beatrice Bhadrayuvadi's sister?
Mohammad Reza Tahmasebi (born 21 March 1976) is an Iranian retired Football player who currently coaches Paykan of the Iran Pro League.
Output: Where was Mohammad Reza Tahmasebi from?
In patients with acute stroke, rapid intervention is crucial to maximise early treatment benefits. Stroke patients commonly have their first contact with medical staff in the emergency room (ER). We designed and validated a stroke recognition tool-the Recognition of Stroke in the Emergency Room (ROSIER) scale-for use by ER physicians. We prospectively collected data for 1 year (development phase) on the clinical characteristics of patients with suspected acute stroke who were admitted to hospital from the ER. We used logistic regression analysis and clinical reasoning to develop a stroke recognition instrument for application in this setting. Patients with suspected transient ischaemic attack (TIA) with no symptoms or signs when assessed in the ER were excluded from the analysis. The instrument was assessed using the baseline 1-year dataset and then prospectively validated in a new cohort of ER patients admitted over a 9-month period. In the development phase, 343 suspected stroke patients were assessed (159 stroke, 167 non-stroke, 32 with TIA [17 with symptoms when seen in ER]). Common stroke mimics were seizures (23%), syncope (23%), and sepsis (10%). A seven-item (total score from -2 to +5) stroke recognition instrument was constructed on the basis of clinical history (loss of consciousness, convulsive fits) and neurological signs (face, arm, or leg weakness, speech disturbance, visual field defect). When internally validated at a cut-off score greater than zero, the instrument showed a diagnostic sensitivity of 92%, specificity of 86%, positive predictive value (PPV) of 88%, and negative predictive value (NPV) of 91%. Prospective validation in 173 consecutive suspected stroke referrals (88 stroke, 59 non-stroke, 26 with TIA [13 with symptoms]) showed sensitivity of 93% (95% CI 89-97), specificity 83% (77-89), PPV 90% (85-95), and NPV 88% (83-93). The ROSIER scale had greater sensitivity than existing stroke recognition instruments in this population. The ROSIER scale was effective in the initial differentiation of acute stroke from stroke mimics in the ER. Introduction of the instrument improved the appropriateness of referrals to the stroke team.
Output: ROSIER scale is used for which disorder?
Convenient location 5 minutes from Washington ,D.C. and one block to Crystal City METRO ,Crystal City Underground. Alexandria. Free Parking, free Deluxe Continental Breakfast and complimentary Hotel Shuttle Service to Ronald Reagan Washington National Airport. 14000 Jefferson Davis Hwy(endurance on S. Eads St.) Phone (703) 979-3722 DAYS INN ARLINGTON Days Inn Arlington is located two miles from the Pentagon ,Lincoln Memorial .There is a restaurant which serves American style food ,plus two meeting rooms and an outdoor pool. Complimentary shuttle service runs to the Rosslyn Metro Station. Complimentary parking is available on the property .An experienced staff welcomes our guests. Phone(703)525-0300 THE HIGHLANDER MOTOR INN Comfortable rooms at moderate rates . Convenient location only minutes away from Washington area attraction. Near VA Square METRO Station and Ballston Commons Shopping Mall. Free continental breakfast ,free parking. Phone(703)524-4300 HYATT REGENCY CRYSTAL CITY Conveniently located next to Washington National Airport and two miles from Washington D.C. Complimentary Shuttle to and from National Airport ,metro ,local restaurants and shopping .Experience a view to remember at out rooftop restaurants "Chesapeake Grill." Call for Reservations. Phone(073)418-12341
Output: Which hotel is close to airports?
With Steigerwalds departure in 1999, Mike Lange shared the broadcast booth with former Penguins defenseman Peter Taglianetti. Taglianetti, a two-time Stanley Cup winner with the team in 1991 and 1992, remained in the position for one season before being replaced by Ed Olczyk. Lange and Olczyk were broadcast partners from 2000 until 2003, when Olczyk left the booth to become the 18th head coach in Penguins history that had become upon due to the firing of previous Head Coach Rick Kehoe after the 200203 season. With Olczyks vacancy, the Penguins hired Bob Errey as their new color commentator for the start of the 200304 season (a position that he continues to hold as of the start of the 201213 season. Lange and Errey remained in the booth until 200506. After 26 seasons in the television broadcast booth, Mike Lange was not retained by FSN Pittsburgh. Instead, he was replaced by former broadcast partner Paul Steigerwald, who remained the TV play-by-play broadcaster for the team until the 201617 season. Lange returned to the radio broadcast booth and currently holds the position of radio play-by-play announcer, the same position he had held with the team in the mid-1970s. Following the 201617 season, Steigerwald moved back to the Penguins front office and NHL Network (U.S. TV network) personality Steve Mears was hired as the new television play-by-play announcer starting with the 201718 season.
Output: Who was play-by-play announcer first, Mears or Lange?
Conker's Bad Fur Day is an action-platform video game developed by Rare for the Nintendo 64 video game console.
Output: Which company developed the videogame Conker's Bad Fur Day?
When did you last visit a shopping mall? In many places, the answer would be "last weekend." Some people go even more often. Why? For one thing, malls offer goods and services that people need all in one place: food, clothing, things for their houses, entertainment, even medical services. So, are malls one of the highlights of modern civilization? Environmental activists would say No! They would go even further and say that consumer behavior is causing a huge environmental disaster. cause consumers of ignorance of the side effect of their shopping--urban sprawl . Social scientists agree that patterns of development have changed the landscape a great deal in the last half century. Before 1950, most people lived in towns or cities and either walked to work or took public transportation. Only very wealthy people had automobiles. Farmers lived in rural areas or isolated villages and came into town only when they needed things they couldn't produce themselves. If you gazed at the landscape you would see towns surrounded by countryside. Then a massive change occurred. Automobiles became affordable and people were quick to adopt them. Now ambitious workers could live in the suburbs, the areas just outside cities, which started to grow rapidly. As long as there was lots of cheap land in the suburbs, no one paid much attention to the usage of that land. Malls, fast food restaurants, cinemas, and car dealerships spread out in large, flat buildings. These one-storey buildings and their parking lot took up a great deal space. Well- meaning farmers thought they were better off selling their land than growing crops. In ignorance, no one realized that once the land was built up in urban sprawl, the good farming land would be ruined forever. There was no way to preserve it. Only in recent years have people come to mourn the old way of life as they have developed insight into the problems. Now people realize that urban sprawl has come with serious environmental problems. The negative aspects of sprawl include air and water pollution, loss of agricultural land, traffic jams, and the death of businesses in the old town centers. Many scholars think the time has come to analyze the problems better so we can develop appropriate policies to control further sprawl. Some think the best way to do is to educate citizens about their priceless environment.
Output: What is the scholars' attitude toward urban sprawl?
Bazex syndrome (acrokeratosis paraneoplastica) is a rare paraneoplastic syndrome that usually occurs in males over 40 years old and is particularly associated with squamous cell carcinoma of the upper aerodigestive tract and adenopathy above the diaphragm. The objectives of our article are (1) to describe a unique case of acrokeratosis paraneoplastica and (2) to review the current literature regarding skin findings, commonly associated neoplasms, and treatment options relative to this condition. We describe a 68-year-old female with lobular breast carcinoma, complicated by local and distant recurrences, who presented with a 1-year history of prominent acral skin and nail changes. Our patient's clinical skin findings improved significantly following treatment and partial remission of her underlying malignancy. Our patient represents one of few females described with this syndrome, which is especially rare in association with lobular breast carcinoma. Further, the patient's presentation is unique as she was discovered to demonstrate laboratory findings consistent with coexistent porphyria cutanea tarda and relative zinc deficiency.
Output: Name synonym of Acrokeratosis paraneoplastica.
Kermit Smith, Jr. (June 7, 1957 -- January 24, 1995) was executed by the state of North Carolina for the kidnap, rape, and murder of a 20-year-old college cheerleader.
Output: Which crime led to the conviction of Kermit Smith, Jr.?
The Tale of Johnny Town-Mouse is a children's book written and illustrated by Beatrix Potter and first published by Frederick Warne & Co. in December 1918.
Output: What is the name of the ilustrator of the book The Tale of Johnny Town-Mouse?
The team rallied for a win over the Washington Redskins at FedExField in week 10. Penalties on Washington's defense helped allow a short McNabb to Brian Westbrook touchdown pass on Philadelphia's opening drive. A fumble by L. J. Smith gave Washington the ball inside Eagle territory, and Jason Campbell capitalized with a touchdown pass to James Thrash, the former Eagle. The extra point was missed, but Campbell hit Thrash for another score later in the second quarter. The two-point conversion failed, leaving it 12-7 Washington. A Redskin field goal stretched Philadelphia's deficit to 15-7 in the third quarter, but L. J. Smith, who spent much of the early season injured, caught an eight-yard touchdown from McNabb. The Eagles went for two to try to tie it, but were not successful. Campbell fired back with his third touchdown pass, this one to Keenan McCardell, to make it 22-13. McNabb needed five plays to get the points back, launching a 45-yard touchdown pass to Reggie Brown for the touchdown. Ladell Betts fumbled the ball away in Eagle territory on Washington's next possession, but McNabb was sacked and fumbled it back to the Redskins on the next play. The Redskins eventually had first-and-goal from the three-yard line, but the Philadelphia defense had yet another huge goal-line stand, and Washington settled for a field goal to go up 25-20. The Eagles got the ball back with four minutes to play, and Westbrook immediately took a short pass and broke free for a 57-yard touchdown to go ahead 26-25 (the two-point conversion failing again). The defense came up big again, with Mike Patterson sacking Campbell to jar the ball loose, and Trent Cole recovering. Westbrook carried it in from ten yards out to seal the deal. McNabb, who surpassed Ron Jaworski for the most career completions in franchise history (2,090 at game's end), passed for 251 yards and four touchdowns in the 33-25 win. Westbrook rushed for 100 yards and had 83 receiving yards, with three total touchdowns. The comeback win improved the Eagles record to 4-5.
Output: Who threw the first touchdown pass of the game?
To validate the presence and demonstrate the clinical value of the type I interferon (IFN)-signature during arthritis development. In 115 seropositive arthralgia patients who were followed for the development of arthritis (Amsterdam Reade cohort), and 25 presymptomatic individuals who developed rheumatoid arthritis (RA) later, and 45 population-based controls (Northern Sweden cohort), the expression levels of 7 type I IFN response genes were determined with multiplex qPCR and an IFN-score was calculated. The diagnostic performance of the IFN-score was evaluated using Cox regression and Receiver Operating Characteristics (ROC)-curve analysis. In 44 of the 115 at-risk individuals (38%) from the Amsterdam Reade cohort, arthritis developed after a median period of 8 months (IQR 5-13). Stratification of these individuals based on the IFN-score revealed that 15 out of 25 IFN(high) individuals converted to arthritis, compared with 29 out of 90 IFN(low) individuals (p=0.011). In the Northern Sweden cohort, the level of the IFN-score was also significantly increased in presymptomatic individuals who developed RA compared with population-based controls (p=0.002). Cox regression analysis of the Amsterdam Reade cohort showed that the hazard ratio (HR) for development of arthritis was 2.38 (p=0.008) for IFN(high) at-risk individuals after correction for anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF). The ROC-curve area under the curve (AUC) for the IFN-score combined with ACPA and RF in the prediction of arthritis was 78.5% (p=0.0001, 95% CI 0.70 to 0.87). The results demonstrated clinical utility for the IFN-signature as a biomarker in the prediction of arthritis development.
Output: Which is the most common gene signature in Rheumatoid Arthritis patients?
A cynical and gothic look at Hollywood during the late 1930s, The Day of the Locust tells the tales of residents of the dilapidated San Bernardino Arms: Faye Greener, a trashy aspiring actress with limited talent, and her father Harry, a washed-up vaudevillian reduced to working as a door-to-door salesman; sexually repressed accountant Homer Simpson, who desperately loves Faye, and East Coast WASP Tod Hackett, an aspiring artist employed by the production department of a major studio, who also fancies Faye. There are unusual and bizarrely disturbing images: a middle-aged man sits in an untended garden staring at a large lizard that stares back; a young woman is transported into the film she's watching and finds herself portraying a harem girl in old Baghdad; a dwarf tenderly caresses a rooster, bleeding and dazed from a cock-fight, and then tosses it back into the ring to its death; an androgynous child beckons to a man through a window and performs a grotesque imitation of Mae West. These brief vignettes do little to advance the basic plot, but they serve to shape the audience's understanding of the era depicted as one of Hollywood sleaziness and wholesale alienation. Spectacle fills the screena set of the Waterloo battlefield collapses on the extras during the making of the film within the film. In the film's climax, an enraged Homer brutally tramples a child near Grauman's Chinese Theater as crowds gather for the premiere of a new film. Seeing this, the enraged crowd swarms over and kills Homer. Almost immediately, the entire crowd is driven to riot, turning on itself, smashing store windows, overturning cars, beating each other to death and turning the already packed street into a war zone. Severely injured, a delirious Tod imagines some of the mob taking on the appearance of the characters in his own grotesque painting The Burning of Los Angeles.
Output: What was the name of Hackett's major work?
Despite the availability of numerous anti-diabetes drugs and treatment guidelines, many patients with type 2 diabetes mellitus (T2DM) do not reach recommended targets for glycemic control. There remains an unmet need for effective and well-tolerated anti-diabetes agents that can be used as monotherapy or in combination with other therapies to improve glycemic control in patients with T2DM. Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new class of treatment for T2DM that reduce hyperglycemia by reducing renal glucose reabsorption and thereby increasing urinary glucose excretion. This paper reviews the pharmacokinetic and pharmacodynamic properties of the SGLT2 inhibitor empagliflozin , the results of clinical trials investigating the efficacy of empagliflozin given as monotherapy or as add-on therapy on glycemic control, body weight, and blood pressure in patients with T2DM, and the safety and tolerability profile of empagliflozin. Empagliflozin offers good glycemic efficacy, weight loss, blood pressure reduction, and a low risk of hypoglycemia. These attributes, coupled with the ability to be used in virtually any combination with other anti-diabetes agents and at any stage in the disease process, provide a welcome new agent to our armamentarium of drugs to help manage T2DM.
Output: Which protein does empagliflozin inhibit?
The Patriots travelled to the Metrodome for a Monday Night Football showdown with the Minnesota Vikings, who, like the Patriots, boasted an excellent run defense. The Patriots, who took to the air with a spread offense for the entire game, opened with a seven-play, 86-yard strike that ended with a touchdown pass from Brady to wide receiver Reche Caldwell. Their next drive was for 93 yards which resulted in a 23-yard Gostkowski field goal. And just before halftime the Patriots moved 74 yards in 11 plays to take a 17-0 lead on a nine-yard scoring toss to tight end Benjamin Watson. The only Vikings score of the game came on a 71-yard punt return by Mewelde Moore in the third quarter; Laurence Maroney immediately answered on the ensuing kickoff, with a 77-yard return to Minnesota's 21-yard line, his second return of over 70 yards in as many weeks. The Patriots' lead grew to 17 after a seven-yard touchdown reception by Brown with 9:03 in the third quarter and then became 31-7 with a touchdown catch by Jackson. The Patriots defense also intercepted four passes from quarterbacks Brad Johnson and Brooks Bollinger. On Bollinger's first drive after relieving Brad Johnson he was sacked three times in a row for a net loss of 23 yards. With their fourth straight victory, the Patriots advanced to 6-1.This was the Patriots' third and final game played in the Metrodome.
Output: Which team scored more touchdowns, the Patriots or the Vikings?
Chrome Hoof are an experimental chamber rock orchestra based in London, England.
Output: From what city is the band Chrome Hoof?
Selenocysteine (Sec) is co-translationally incorporated into selenoproteins at a reprogrammed UGA codon. In mammals, this requires a dedicated machinery comprising a stem-loop structure in the 3' UTR RNA (the SECIS element) and the specific SECIS Binding Protein 2. In this report, disorder-prediction methods and several biophysical techniques showed that ca. 70% of the SBP2 sequence is disordered, whereas the RNA binding domain appears to be folded and functional. These results are consistent with a recent report on the role of the Hsp90 chaperone for the folding of SBP2 and other functionally unrelated proteins bearing an RNA binding domain homologous to SBP2.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
The Dragon Family () is a 1988 Hong Kong action film directed by Lau Kar-wing starring Andy Lau, Alan Tam and Max Mok.
Output: What year did The Dragon Family come out?
Grant Heslov (born May 15, 1963) is an American actor, film producer, screenwriter and director, known for producing Argo (2012) for which he received an Academy Award for Best Picture as co-producer in 2013.
Output: What was Grant Heslov nominated for?
Although mining provides people with many needed resources, the environmental costs can be high. Surface mining clears the landscape of trees and soil, and nearby streams and lakes are inundated with sediment. Pollutants from the mined rock, such as heavy metals, enter the sediment and water system. Acids flow from some mine sites, changing the composition of nearby waterways (Figure 1.1). U.S. law has changed in recent decades so that a mine region must be restored to its natural state, a process called reclamation. This is not true of older mines. Pits may be refilled or reshaped and vegetation planted. Pits may be allowed to fill with water and become lakes or may be turned into landfills. Underground mines may be sealed off or left open as homes for bats. Click image to the left or use the URL below. URL: Acid drainage from a surface coal mine in Missouri.
Output: according to u.s. law, a mine region
Diamphidia nigroornata or Bushman arrow-poison beetle, is an African leaf beetle species in the genus Diamphidia.
Output: Is Diamphidia nigroornata a genus or species?
This tryptch is missing a panel, lost when it was disassembled in 1777, but the panel with St. Anthony Beaten by Devils is currently on display at the Pinacoteca Nazionale.
Output: What is the name of the place where St. Anthony Beaten by Devils can be found?
The X-linked McLeod neuroacanthocytosis syndrome strongly resembles Huntington's disease and has been reported in various countries world-wide. Herein, we report two Chilean brothers with predominant psychiatric features at disease onset including schizophrenia-like psychosis and obsessive compulsive disorder. Molecular genetic analysis revealed a small deletion in the XK gene (938-942delCTCTA), which has been already described in a North American patient of Anglo-Saxon descent and a Japanese family, presenting with seizures, muscle atrophy or chorea yet absence of psychiatric features. These findings argue against a founder effect and indicate a profound phenotypic variability associated with the 938-942delCTCTA deletion. Our report supports the inclusion of McLeod syndrome in the differential diagnosis of Huntington's disease as well as acute psychosis in male subjects.
Output: Mutation of which gene is associated with McLeod syndrome?
Vukadin Vukadinovic (born 14 December 1990) is a professional Serbian football midfielder currently playing for FC Fastav Zlin on loan from FK Baumit Jablonec.
Output: For which sports team does Vukadin Vukadinović play?
More than 6000 children were expelled from US schools last year for bringing guns and bombs to school, the US Department of Education said on May 8. The department gave a report on the expulsions as saying handguns accounted for 58 percent of the 6093 expulsions in 2005--2006, against 7 percent for rifles or shotguns and 35 percent for other types of firearms. "the report is a dear sign that our nation's public schools are cracking down" on students who bring guns to school, " Education Secretary Richard Riey said in a statement. "We need to be tough-minded about keeping guns out of our schools and do everything to keep our children safe." In March 2006, a 1l-year-old boy and a 13-year-old boy using handguns and rifles shot dead four children and a teacher at a school in Jonesboro, Arkansas. In October, two were killed and seven wounded in a shooting at a Mississippi school. Two months later, a 14-year-old boy killed three high school students and wounded five in Daducab, Kentucky. "Most of the expulsions, 56 percent were from high schools, which have students from about age 13, 34 percent were from junior high schools and 9 percent were from elementary schools", the report said.
Output: How many students were shot dead in 2006 in US schools?
In August 2010 it acquired its parent Inergy Holdings which had also traded on the New York Stock Exchange under the ticker symbol NRGP in a deal valued at $2 billion with the resulting company being reported to be worth $6 billion.
Output: What stock exchange is Inergy associated with?
Processive versus distributive methyl group transfer was assessed for pea Rubisco large subunit methyltransferase, a SET domain protein lysine methyltransferase catalyzing the formation of trimethyllysine-14 in the large subunit of Rubisco. Catalytically competent complexes between an immobilized form of des(methyl) Rubisco and Rubisco large subunit methyltransferase were used to demonstrate enzyme release that was co-incident with and dependent on formation of trimethyllysine. Catalytic rate constants determined for formation of trimethyllysine were considerably lower ( approximately 10-fold) than rate constants determined for total radiolabel incorporation from [3H-methyl]-S-adenosylmethionine. Double-reciprocal velocity plots under catalytic conditions favoring monomethyllysine indicated a random or ordered reaction mechanism, while conditions favoring trimethyllysine suggested a hybrid ping-pong mechanism. These results were compared with double-reciprocal velocity plots and product analyses obtained for HsSET7/9 (a monomethyltransferase) and SpCLR4 (a dimethyltransferase) and suggest a predictive ability of double-reciprocal velocity plots for single versus multiple methyl group transfers by SET domain protein lysine methyltransferases. A model is proposed for SET domain protein lysine methyltransferases in which initial binding of polypeptide substrate and S-adenosylmethionine is random, with polypeptide binding followed by deprotonation of the epsilon-amine of the target lysyl residue and subsequent methylation. Following methyl group transfer, S-adenosylhomocysteine and monomethylated polypeptide dissociate from monomethyltransferases, but di- and trimethyltransferases begin a successive and catalytically obligatory deprotonation of enzyme-bound methylated lysyl intermediates, which along with binding and release of S-adenosylmethionine and S-adenosylhomocysteine is manifested as a hybrid ping-pong-like reaction mechanism.
Output: What is the characteristic domain of histone methyltransferases?
The 49ers would trail 20-13 with less than a minute to go. Blaine Gabbert would run in a game-tying 44 yard touchdown to tie the game at 20. The Bears appeared to have the game won when they went down the field after a decent kick return by Deonte Thompson for 74 yards. Robbie Gould came out to attempt a game-winning 36 yard field goal, but the kick was wide left, resulting in overtime. In the overtime period, Gabbert would throw the game-winning 71-yard touchdown pass to Torrey Smith to win the game for San Francisco. This was San Francisco's first win in Chicago since the 1989 NFC Championship Game.
Output: Who threw the longest touchdown pass in overtime?
Penobscot tribal chiefs expressed a willingness to enter peace talks with Lieutenant Governor Dummer in December 1724. They were opposed in this by French authorities, who continued to encourage the conflict, but Massachusetts Lieutenant Governor Dummer announced a cessation of hostilities on 31 July 1725 following negotiations in March.:83 The terms of this preliminary agreement were negotiated by Dummer and Chiefs Loron and Wenemouet and applied only to the Penobscots at first. They were allowed to retain Jesuit priests, but the two parties were in disagreement concerning land titles and British sovereignty over the Wabanakis. The written agreement was translated into Abenaki by French Jesuit Etienne Lauverjat; Chief Loron immediately repudiated it, specifically rejecting claims of British sovereignty over him. Despite his disagreement, Loron pursued peace, sending wampum belts to other tribal leaders, although his envoys were unsuccessful in reaching Gray Lock, who continued his raiding expeditions. Peace treaties were signed in Maine on 15 December 1725 and in Nova Scotia on 15 June 1726, involving a large number of tribal chiefs. The peace was reconfirmed by all except Gray Lock at a major gathering at Falmouth in the summer of 1727; other tribal envoys claimed that they were not able to locate him. Gray Lock's activity came to an end in 1727, after which time he disappears from English records.
Output: At what event was Gray Lock discovered to be missing?
The structurally novel macrolide FK506 (refs 1,2) has recently been demonstrated to have potent immunosuppressive activity at concentrations several hundredfold lower than cyclosporin A (CsA). Cyclosporin A, a cyclic peptide, has found widespread clinical use in the prevention of graft rejection following bone marrow and organ transplantation. The mechanisms of immunosuppression mediated by FK506 and CsA appear to be remarkably similar, suggesting that these unrelated structures act on a common receptor or on similar molecular targets, perhaps the CsA receptor, cyclophilin, which has recently been shown by Fischer et al. and Takahashi et al. to have cis-trans peptidyl-prolyl isomerase activity. We have prepared an FK506 affinity matrix and purified a binding protein for FK506 from bovine thymus and from human spleen. This FK506-binding protein (FKBP) has a relative molecular mass (Mr) of approximately 14,000(14K), a pI of 8.8-8.9, and does not cross-react with antisera against cyclophilin. The first 40 N-terminal residues of the bovine and 16 residues of the human FKBP were determined; the 16-residue fragments are identical to each other and unrelated to any known sequences. This protein catalyses the cis-trans isomerization of the proline amide in a tetrapeptide substrate and FK506 inhibits the action of this new isomerase. The FKBP and cyclophilin appear to be members of an emerging class of novel proteins that regulate T cell activation and other metabolic processes, perhaps by the recognition (and possibly the isomerization) of proline-containing epitopes in target proteins.
Output: Which is the receptor for the immunosuppressive drug cyclosporin A (CsA)?
The 2009 Grand Prix SAR La Princesse Lalla Meryem was a tennis tournament played on outdoor clay courts.
Output: Which sport is associated with 2009 Grand Prix SAR La Princesse Lalla Meryem?
Francis Folger Franklin (October 20, 1732 -- November 21, 1736) was the eldest son of Founding Father of the United States Benjamin Franklin by Deborah Read.
Output: Who was the male parent of Francis Folger Franklin?
Lesla-Lar is a fictional character, a supervillain in the DC Universe.
Output: What is the fictional universe that Lesla-Lar belong to?
Chronic myeloid leukemia (CML) arises as a consequence of a chromosomal translocation giving rise to the Philadelphia chromosome and Bcr-Abl oncogene. CML is a clonal disease of stem cell origin and an excellent example of a malignancy in which tumor-initiating cells may hold the key to disease eradication. The known molecular basis of CML has enabled the development of Abl-specific tyrosine kinase inhibitors, such as imatinib mesylate. However, the success of tyrosine kinase inhibitors, as rationally designed first-line therapies, has been tempered by problems of disease persistence and resistance. Residual disease has been shown to be enriched within the stem cell compartment and to persist at stable levels for up to 5 years of complete cytogenetic response. This finding has led to further searches for novel strategies aimed at eliminating these cells; such strategies may be essential in achieving cure. The most significant recent findings are discussed in this review.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
City at the End of Time is a 2008 science fiction novel by American writer Greg Bear.
Output: Which series is City at the End of Time apart of?
Hatra defeated the Iranians at the battle of Shahrazoor in 238, but fell to the Iranian Sassanid Empire of Shapur I in 241 and was destroyed.
Output: When was Hatra abolished?
Dele Adeleye and Sani Kaita- through a statement on their official website, FC Tavria, Dele Adeleye, in the Nigeria squad for two live-wire games against Madagascar on Sunday, comes from Donetsk Metallurg, where he scored three goals in 26 appearances from central defense.
Output: What is Dele Adeleye's country of original?
Histone H3 lysine 9 (H3K9) methylation is a major component of gene regulation and chromatin organization. SUV39H1 methylates H3K9 at the pericentric heterochromatin region and participates in the maintenance of genome stability. In this study, a recombinant purified SUV39H1 is used for substrate specificity and steady-state kinetic analysis with peptides representing the un- or dimethylated lysine 9 histone H3 tail or full-length human recombinant H3 (rH3). Recombinant SUV39H1 methylated its substrate via a nonprocessive mechanism. Binding of either peptide or AdoMet first to the enzyme made a catalytically competent binary complex. Product inhibition studies with SUV39H1 showed that S-adenosyl-l-homocysteine is a competitive inhibitor of S-adenosyl-l-methionine and a mixed inhibitor of substrate peptide. Similarly, the methylated peptide was a competitive inhibitor of the unmethylated peptide and a mixed inhibitor of AdoMet, suggesting a random mechanism in a bi-bi reaction for recombinant SUV39H1 in which either substrate can bind to the enzyme first and either product can release first. The turnover numbers (k(cat)) for the H3 tail peptide and rH3 were comparable (12 and 8 h(-)(1), respectively) compared to the value of 1.5 h(-)(1) for an identical dimethylated lysine 9 H3 tail peptide. The Michaelis constant for the methylated peptide (K(m)(pep)) was 13-fold lower compared to that of the unmethylated peptide. The Michaelis constants for AdoMet (K(m)(AdoMet)) were 12 and 6 microM for the unmethylated peptide substrate and rH3, respectively. A reduction in the level of methylation was observed at high concentrations of rH3, implying substrate inhibition. Deletion of the chromodomain or point mutation of the conserved amino acids, W64A or W67A, of SUV39H1 impaired enzyme activity despite the presence of an intact catalytic SET domain. Thus, SUV39H1 utilizes both the chromodomain and the SET domain for catalysis.
Output: What is the characteristic domain of histone methyltransferases?
When creating a digital advertisement or something to promote a product or service ,music is one of the most important aspects. Whether it is simply a jingle ,musical note or any other use of sound,music can play a huge role in attracting a customer's attention or being noticed by your target audience. Music can work hand-in-hand with what you are advertising. Many times the advertising jingle, or saying, is what the audience remembers. Companies such as McDonald's and Subway have used this method many times with different jingles and little sayings that are easy to remember and fun to sing along with. Usually concepts that are part of a jingle would sound conceited and pompous when said in a normal conversation. When put to music however, and sung in a rhythm,it suddenly sounds attractive. For example, if someone said," No one does it better than me" in a normal statement, this would sound very conceited. Add music and a tune to this statement and it becomes attractive and fun for others to sing along with. While understanding how important music is for your advertising needs, it is also important for you to know the best way to get special music. Having people from many different backgrounds all over the world write something specifically for you is one of the best ways to get songs written just for you. You simply choose which one you believe is best for the project. So instead of hiring a single songwriter to compose your music, you can run a contest for you advertising jingle and songwriters around the world write you a finished jingle in an attempt to win your contest.
Output: What makes concepts of an advertising jingle sound attractive?
Ishak Bey Kraloglu (Serbo-Croatian: Ishak-beg Kraljevic/- ), christened Sigismund Tomasevic, was a Bosnian prince, the last known member of the House of Kotromanic and an Ottoman statesman.
Output: What was the noble family that Ishak Bey Kraloğlu was from?