niryuu/sni-each-converted huggingface dataset:
Phoebe Campbell (c. 1847 -- 20 June 1872) was a Canadian woman who was hanged for the murder of her husband.
Output: Which crime Phoebe Campbell is considered to have commited?
The Get Up Kids are an American rock band from Kansas City, Missouri.
Output: What city was The Get Up Kids formed in?
Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor B ligand (RANKL) has been identified as a pivotal paracrine mediator of progesterone function in mouse mammary gland development and mammary carcinogenesis. Whether the factor has the same role in humans is of clinical interest because an inhibitor for RANKL, denosumab, is already used for the treatment of bone disease and might benefit breast cancer patients. We show that progesterone receptor (PR) signaling failed to induce RANKL in PR(+) breast cancer cell lines and in dissociated, cultured breast epithelial cells. In clinical specimens from healthy donors and intact breast tissue microstructures, hormone response was maintained and RANKL expression was under progesterone control, which increased RNA stability. RANKL was sufficient to trigger cell proliferation and was required for progesterone-induced proliferation. The findings were validated in vivo where RANKL protein expression in the breast epithelium correlated with serum progesterone levels and the protein was expressed in a subset of luminal cells that express PR. Thus, important hormonal control mechanisms are conserved across species, making RANKL a potential target in breast cancer treatment and prevention.
Output: To the ligand of which receptors does Denosumab (Prolia) bind?
Radioactivity is the tendency of certain atoms to decay into lighter atoms, a process that emits energy. Radioactivity also provides a way to find the absolute age of a rock. First, we need to know about radioactive decay. Some isotopes are radioactive; radioactive isotopes are unstable and spontaneously change by gaining or losing particles. Two types of radioactive decay are relevant to dating Earth materials (Table 1.1): Particle Alpha Composition 2 protons, 2 neutrons Beta 1 electron Effect on Nucleus The nucleus contains two fewer protons and two fewer neutrons. One neutron decays to form a pro- ton and an electron. The electron is emitted. The radioactive decay of a parent isotope (the original element) leads to the formation of stable daughter product, also known as daughter isotope. As time passes, the number of parent isotopes decreases and the number of daughter isotopes increases (Figure 1.1). Radioactive materials decay at known rates, measured as a unit called half-life. The half-life of a radioactive substance is the amount of time it takes for half of the parent atoms to decay. This is how the material decays over time (see Table 1.2). No. of half lives passed 0 1 2 3 4 5 6 7 8 Percent parent remaining 100 50 25 12.5 6.25 3.125 1.563 0.781 0.391 Percent daughter produced 0 50 75 87.5 93.75 96.875 98.437 99.219 99.609 Pretend you find a rock with 3.125% parent atoms and 96.875% daughter atoms. How many half lives have passed? If the half-life of the parent isotope is 1 year, then how old is the rock? The decay of radioactive materials can be shown with a graph (Figure 1.2). Notice how it doesnt take too many half lives before there is very little parent remaining and most of the isotopes are daughter isotopes. This limits how many half lives can pass before a radioactive element is no longer useful for Decay of an imaginary radioactive sub- stance with a half-life of one year. dating materials. Fortunately, different isotopes have very different half lives. Click image to the left or use the URL below. URL:
Output: radioactive decay of an isotope leads to the formation of a ____________ product.
The 39th government of Turkey (31 March 1975 -- 21 June 1977) was a historical government of Turkey.
Output: What year did 39th government of Turkey start?
TVN24 Biznes i Swiat (TVN24 BiS; Polish: TVN24 Business and World) is a Polish 24-hour hybrid business and world news channel, sister station to TVN24.
Output: Which industry is TVN24 Biznes i Świat associated with?
Louis Armstrong had two famous nicknames. Some people called him Bagamo. They said his mouth looked like a large bag. Musicians often called him Pops, as a sign of respect for his influence on the world of music. Born in 1901 in New Orleans, he grew up poor, but lived among great musicians. Jazz was invented in the city a few years before his birth. Armstrong often said,"Jazz and I grew up together." Armstrong showed a great talent for music when he was taught to play the cornet at a boy's home. In his late teens, Armstrong began to live the life of a musician. He played in parades, clubs, and on the steam-boats that travelled on the Mississippi River. At that time, New Orleans was famous for the new music of jazz and was home to many great musicians. Armstrong learned from the older musicians and soon became respected as their equal. In 1922 he went to Chicago. There, the tale of Louis Armstrong begins. From then until the end of his life, Armstrong was celebrated and loved wherever he went. Armstrong had no equal when it came to playing the American popular song. His cornet playing had a deep humanity and warmth that caused many listeners to say,"Listening to Pops just makes you feel good all over."He was the father of the jazz style and also one of the best-known and most-admired people in the world. His death, on July 6 , 1971, was headline news around the world.
Output: Which would be best title for the text?
The McLeod syndrome is an X-linked disorder caused by mutations of the XK gene encoding the XK protein. The syndrome is characterized by absent Kx erythrocyte antigen, weak expression of Kell blood group system antigens, and acanthocytosis. In some allelic variants, elevated creatine kinase, myopathy, neurogenic muscle atrophy, and progressive chorea are found. We describe a family with a novel point mutation in the XK gene consisting of a C to T base transition at nucleotide position 977, introducing a stop codon. Among seven affected males, five manifested with psychiatric disorders such as depression, bipolar disorder, or personality disorder, but only two presented with chorea Positron emission tomography and magnetic resonance volumetry revealed reduced striatal 2-fluoro-2-deoxy-glucose (FDG) uptake and diminished volumes of the caudate nucleus and putamen that correlated with disease duration. In contrast, none of 12 female mutation carriers showed psychiatric or movement disorders. However, a semidominant effect of the mutation was suggested by erythrocyte and blood group mosaicism and reduced striatal FDG uptake without structural abnormalities. Therefore, patients with psychiatric signs or symptoms segregating in an X-linked trait should be examined for acanthocytosis and Kell/Kx blood group serology.
Output: Mutation of which gene is associated with McLeod syndrome?
Wave speed is the distance a wave travels in a given amount of time, such as the number of meters it travels per second. Wave speed (and speed in general) can be represented by the equation: Speed = Distance Time Wave speed is related to both wavelength and wave frequency. Wavelength is the distance between two correspond- ing points on adjacent waves. Wave frequency is the number of waves that pass a fixed point in a given amount of time. This equation shows how the three factors are related: Speed = Wavelength x Wave Frequency In this equation, wavelength is measured in meters and frequency is measured in hertz (Hz), or number of waves per second. Therefore, wave speed is given in meters per second, which is the SI unit for speed. Q: If you increase the wavelength of a wave, does the speed of the wave increase as well? A: Increasing the wavelength of a wave doesnt change its speed. Thats because when wavelength increases, wave frequency decreases. As a result, the product of wavelength and wave frequency is still the same speed. Click image to the left or use the URL below. URL: The equation for wave speed can be used to calculate the speed of a wave when both wavelength and wave frequency are known. Consider an ocean wave with a wavelength of 3 meters and a frequency of 1 hertz. The speed of the wave is: Speed = 3 m x 1 wave/s = 3 m/s Q: Kim made a wave in a spring by pushing and pulling on one end. The wavelength is 0.1 m, and the wave frequency is 2 hertz. What is the speed of the wave? A: Substitute these values into the equation for speed: Speed = 0.1 m x 2 waves/s = 0.2 m/s The equation for wave speed (above) can be rewritten as: Frequency = Speed Wavelength or Wavelength = Speed Frequency Therefore, if you know the speed of a wave and either the wavelength or wave frequency, you can calculate the missing value. For example, suppose that a wave is traveling at a speed of 2 meters per second and has a wavelength of 1 meter. Then the frequency of the wave is: Frequency = 2m/s 1m = 2 waves/s, or 2 Hz Q: A wave is traveling at a speed of 2 m/s and has a frequency of 2 Hz. What is its wavelength? A: Substitute these values into the equation for wavelength: Wavelength = 2m/s 2waves/s =1m The speed of most waves depends on the medium, or the matter through which the waves are traveling. Generally, waves travel fastest through solids and slowest through gases. Thats because particles are closest together in solids and farthest apart in gases. When particles are farther apart, it takes longer for the energy of the disturbance to pass from particle to particle through the medium. Click image to the left or use the URL below. URL:
Output: speed can be calculated with the equation
Jedrzej Mackowiak (born October 17, 1992 in Bechatow, Poland) is a Polish volleyball player, a member of Polish club Effector Kielce, Polish Champion.
Output: What is the name of Jędrzej Maćkowiak's team?
The DeLorean DMC-12 (commonly referred to simply as the DeLorean as it was the only model ever produced by the company) is a sports car manufactured by John DeLorean's DeLorean Motor Company for the American market from 1981--83.
Output: What year did DeLorean DMC-12 start?
Dorothee Bar (nee Mantel, born 19 April 1978 in Bamberg, Bavaria) is a German politician that has served as the National Deputy Secretary General of the Christian Social Union of Bavaria since 2009.
Output: From which political party is Dorothee Bär?
To assess the efficacy and safety of R788 (fostamatinib disodium), an inhibitor of spleen tyrosine kinase (Syk), in patients with active rheumatoid arthritis (RA) that did not respond to biologic therapies. A total of 219 patients with active RA in whom treatment with biologic agents had failed were enrolled in a 3-month multicenter, randomized, double-blind, placebo-controlled trial of R788. The primary end point was the percentage of patients who met the American College of Rheumatology 20% improvement criteria (achieved an ACR20 response) at month 3. Secondary end points included changes in inflammation and damage, as assessed by magnetic resonance imaging (MRI), and changes in the Disease Activity Score. The ACR20 response in the R788 100 mg twice daily group was 38%, versus 37% in the placebo group, at month 3. No significant differences were achieved in the ACR20, ACR50, or ACR70 response levels at 3 months. There were differences between the groups from baseline to month 3 in the secondary end points C-reactive protein (CRP) level and synovitis score on MRI. There were baseline differences in steroid use, prior biologic use, and synovitis score on MRI between the R788 group and the placebo group that may have affected the outcomes. A high placebo response rate was seen in this trial, and exploratory analysis suggested that this may in part have been driven by patients who entered the trial with an elevated erythrocyte sedimentation rate but normal CRP level. Our findings indicate that there were no differences in the primary end point between the R788 and placebo groups. Differences were observed between the R788 and placebo groups in secondary end points, particularly in those patients who entered the study with an elevated CRP level.
Output: Which enzyme is inhibited by a drug fostamatinib?
A pivotal phase III study of the RTS,S/AS01 malaria candidate vaccine is ongoing in several research centres across Africa. The development and establishment of quality systems was a requirement for trial conduct to meet international regulatory standards, as well as providing an important capacity strengthening opportunity for study centres. Standardized laboratory methods and quality assurance processes were implemented at each of the study centres, facilitated by funding partners. A robust protocol for determination of parasite density based on actual blood cell counts was set up in accordance with World Health Organization recommendations. Automated equipment including haematology and biochemistry analyzers were put in place with standard methods for bedside testing of glycaemia, base excess and lactacidaemia. Facilities for X-rays and basic microbiology testing were also provided or upgraded alongside health care infrastructure in some centres. External quality assurance assessment of all major laboratory methods was established and method qualification by each laboratory demonstrated. The resulting capacity strengthening has ensured laboratory evaluations are conducted locally to the high standards required in clinical trials. Major efforts by study centres, together with support from collaborating parties, have allowed standardized methods and robust quality assurance processes to be put in place for the phase III evaluation of the RTS, S/AS01 malaria candidate vaccine. Extensive training programmes, coupled with continuous commitment from research centre staff, have been the key elements behind the successful implementation of quality processes. It is expected these activities will culminate in healthcare benefits for the subjects and communities participating in these trials. Clinicaltrials.gov NCT00866619.
Output: RTS S AS01 vaccine was developed to prevent which disease?
In melanoma, transition to the vertical growth phase is the critical step in conversion to a deadly malignant disease. Here, we offer the first evidence that an antioxidant enzyme has a key role in this transition. We found that the antioxidant enzyme peroxiredoxin-2 (Prx2) inversely correlated with the metastatic capacity of human melanoma cells. Silencing Prx2 expression stimulated proliferation and migration, whereas ectopic expression of Prx2 produced the opposite effect. Mechanistic investigations indicated that Prx2 negatively regulated Src/ERK activation status, which in turn fortified adherens junctions function by increasing E-cadherin expression and phospho-Y654-dependent retention of -catenin in the plasma membrane. In murine melanoma cells, Prx2 silencing enhanced lung metastasis in vivo. Interestingly, the natural compound gliotoxin, which is known to exert a Prx-like activity, inhibited proliferation and migration as well as lung metastasis of Prx2-deficient melanoma cells. Overall, our findings reveal that Prx2 is a key regulator of invasion and metastasis in melanoma, and also suggest a pharmacologic strategy to effectively decrease deadly malignant forms of this disease.
Output: What type of enzyme is peroxiredoxin 2 (PRDX2)?
The stratum corneum (SC) is the outermost region of the epidermis and plays key roles in cutaneous barrier function in mammals. The SC is composed of 'bricks', represented by flattened, protein-enriched corneocytes, and 'mortar', represented by intercellular lipid-enriched layers. As a result of this 'bricks and mortar' structure, the SC can be considered as a 'rampart' that encloses water and solutes essential for physiological homeostasis and that protects mammals from physical, chemical and biological assaults. The corneocyte cytoskeleton contains tight bundles of keratin intermediate filaments aggregated with filaggrin monomers, which are subsequently degraded into natural moisturizing compounds by various proteases, including caspase 14. A cornified cell envelope is formed on the inner surface of the corneocyte plasma membrane by transglutaminase-catalysed cross-linking of involucrin and loricrin. Ceramides form a lipid envelope by covalently binding to the cornified cell envelope, and extracellular lamellar lipids play an important role in permeability barrier function. Corneodesmosomes are the main adhesive structures in the SC and are degraded by certain serine proteases, such as kallikreins, during desquamation. The roles of the different SC components, including the structural proteins in corneocytes, extracellular lipids and some proteins associated with lipid metabolism, have been investigated in genetically engineered mice and in naturally occurring hereditary skin diseases, such as ichthyosis, ichthyosis syndrome and atopic dermatitis in humans, cattle and dogs.
Output: What are the structures formed when keratin molecules come together?
Kicking in the Water is the second album by Canadian band The Gandharvas.
Output: What artist was responsible for the creation of Kicking in the Water?
Molecular recognition features (MoRFs) are small, intrinsically disordered regions in proteins that undergo a disorder-to-order transition on binding to their partners. MoRFs are involved in protein-protein interactions and may function as the initial step in molecular recognition. The aim of this work was to collect, organize and store all membrane proteins that contain MoRFs. Membrane proteins constitute 30% of fully sequenced proteomes and are responsible for a wide variety of cellular functions. MoRFs were classified according to their secondary structure, after interacting with their partners. We identified MoRFs in transmembrane and peripheral membrane proteins. The position of transmembrane protein MoRFs was determined in relation to a protein's topology. All information was stored in a publicly available mySQL database with a user-friendly web interface. A Jmol applet is integrated for visualization of the structures. mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins. [Link]
Output: Which is the database of molecular recognition features in membrane proteins?
''Wolves Beyond the Border'' is one of the original stories by Robert E. Howard about Conan the Cimmerian, a fragment begun in the 1930s but not finished or published in Howard's lifetime.
Output: Who was Wolves Beyond the Border written by?
Sickle cell anemia (SCA) is an autosomal recessive disease caused by the HBB:c.20A>T mutation that leads to hemoglobin S synthesis. The disease presents with high clinical heterogeneity characterized by chronic hemolysis, recurrent episodes of vaso-oclusion and infection. This work aimed to characterize by in silico studies some genetic modulators of severe hemolysis and stroke risk in children with SCA, and understand their consequences at the hemorheological level.Association studies were performed between hemolysis biomarkers as well as the degree of cerebral vasculopathy and the inheritance of several polymorphic regions in genes related with vascular cell adhesion and vascular tonus in pediatric SCA patients. In silico tools (e.g. MatInspector) were applied to investigate the main variant consequences.Variants in vascular adhesion molecule-1 (VCAM1) gene promoter and endothelial nitric oxide synthase (NOS3) gene were significantly associated with higher degree of hemolysis and stroke events. They potentially modify transcription factor binding sites (e.g. VCAM1 rs1409419_T allele may lead to an EVI1 gain) or disturb the corresponding protein structure/function. Our findings emphasize the relevance of genetic variation in modulating the disease severity due to their effect on gene expression or modification of protein biological activities related with sickled erythrocyte/endothelial interactions and consequent hemorheological abnormalities.
Output: What gene is mutated in Sickle Cell Anemia?
The Santer-Poos Ministry II was the government of Luxembourg between 14 July 1989 and 13 July 1994.
Output: What year did Santer-Poos Ministry II start?
Successful mining took time and capital, particularly once most of the timber around the Klondike had been cut down. A realistic mining operation required $1,500 for wood to be burned to melt the ground, along with around $1,000 to construct a dam, $1,500 for ditches and up to $600 for sluice boxes, a total of $4,600. The attraction of the Klondike to a prospector, however, was that when gold was found, it was often highly concentrated. Some of the creeks in the Klondike were fifteen times richer in gold than those in California, and richer still than those in South Africa. In just two years, for example, $230,000 worth of gold was brought up from claim 29 on the Eldorado Creek.
Output: Where was gold more prevalent
Csaba Bernath (Hungarian pronunciation: (tb brnat); born 26 March 1979) in Debrecen is a Hungarian footballer who currently plays for Debreceni VSC.
Output: What team does Csaba Bernáth play for?
The film starts on June 16, 1994 with Jesse meeting Celine on a train from Budapest and striking up a conversation with her. Jesse is going to Vienna to catch a flight back to the United States, whereas Celine is returning to university in Paris after visiting her grandmother. When they reach Vienna, Jesse convinces Celine to disembark with him, saying that 10 or 20 years down the road, she might not be happy with her marriage and might wonder how her life would have been different if she had picked another guy, and this is a chance to realize that he himself is not that different from the rest; in his words, he is "the same boring, unmotivated guy." Jesse has to catch a flight early in the morning and does not have enough money to rent a room for the night, so they decide to roam around in Vienna. After visiting a few landmarks in Vienna, they share a kiss at the top of the Wiener Riesenrad at sunset and start to feel a romantic connection. As they continue to roam around the city, they begin to talk more openly with each other, with conversations ranging from topics about love, life, religion, and their observations of the city. Celine tells Jesse that her last boyfriend broke up with her six months ago, claiming that she "loved him too much". When questioned, Jesse reveals he had initially come to Europe to spend time with his girlfriend who was studying in Madrid, but they had broken up when she was avoiding him while he was there. He decided to take a cheap flight home, via Vienna, but it did not leave for two weeks so he bought a Eurail pass and traveled around Europe. When they are walking alongside the Donaukanal (Danube canal) they are approached by a man who, instead of begging, offers to write them a poem with a word of their choice in it. Jesse and Celine decide on the word "milkshake", and are soon presented with the poem Delusion Angel (written for the film by the poet David Jewell). In a traditional Viennese cafe, Jesse and Celine stage fake phone conversations with each other, playing each other's friends they pretend to call. Celine reveals that she was ready to get off the train with Jesse before he convinced her. Jesse reveals that after he broke up with his girlfriend, he bought a flight that really was not much cheaper, and all he really wanted was an escape from his life. They admit their attraction to each other and how the night has made them feel, though they understand that they probably will not see each other again when they leave. They simply decide to make the best of what time they have left, ending the night with the implication of a sexual encounter between them. At that point, Jesse explains that if given the choice, he would marry her instead of never seeing her again. The film ends the next day at the train station, where, just as Celine's train is about to leave, the couple decides not to exchange any contact information but instead to meet at the same place in six months.
Output: Strangers on a train, Jesse convinces Cline to disembark with him in what city?
Maximian committed suicide in the summer of 310 on Constantine's orders.
Output: In one word, how did Maximian die?
Britomart Redeems Faire Amoret is an oil painting on canvas by English artist William Etty, first exhibited in 1833 and now in Tate Britain.
Output: What is the name of the place where Britomart Redeems Faire Amoret can be found?
La Mort de Balzac (The Death of Balzac) by Octave Mirbeau is a collection of three sub-chapters that were initially intended to appear in Mirbeau's La 628-E8, in November 1907, but were then withdrawn at the last moment at the request of the 80-year daughter of Madame Hanska, the Countess of Mniszech.
Output: Who was the auther of La Mort de Balzac?
Calcineurin signaling has been implicated in a broad spectrum of developmental processes in a variety of organ systems. Calcineurin is a calmodulin-dependent, calcium-activated protein phosphatase composed of catalytic and regulatory subunits. The serine/threonine-specific phosphatase functions within a signal transduction pathway that regulates gene expression and biological responses in many developmentally important cell types. Calcineurin signaling was first defined in T lymphocytes as a regulator of nuclear factor of activated T cells (NFAT) transcription factor nuclear translocation and activation. Recent studies have demonstrated the vital nature of calcium/calcineurin/NFAT signaling in cardiovascular and skeletal muscle development in vertebrates. Inhibition, mutation, or forced expression of calcineurin pathway genes result in defects or alterations in cardiomyocyte maturation, heart valve formation, vascular development, skeletal muscle differentiation and fiber-type switching, and cardiac and skeletal muscle hypertrophy. Conserved calcineurin genes are found in invertebrates such as Drosophila and Caenorhabditis elegans, and genetic studies have demonstrated specific myogenic functions for the phosphatase in their development. The ability to investigate calcineurin signaling pathways in vertebrates and model genetic organisms provides a great potential to more fully comprehend the functions of calcineurin and its interacting genes in heart, blood vessel, and muscle development.
Output: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
Binny Nwe' escaped to Dagon, leaving Talamidaw with their son, Bawlawkyantaw.
Output: Who is the offspring of Talamidaw?
Interleukin-1 (IL-1) is a potent mediator of inflammatory responses and plays a role in the differentiation of a number of lymphoid cells. In several inflammatory and autoimmune diseases, serum levels of IL-1 are elevated and correlate with disease development and severity. The central role of the IL-1 pathway in several diseases has been validated by inhibitors currently in clinical development or approved by the FDA. However, the need to effectively modulate IL-1-mediated local inflammation with the systemic delivery of an efficacious, safe and convenient drug still exists. To meet these challenges, we developed XOMA 052 (gevokizumab), a potent anti-IL-1 neutralizing antibody that was designed in silico and humanized using Human Engineering™ technology. XOMA 052 has a 300 femtomolar binding affinity for human IL-1 and an in vitro potency in the low picomolar range. XOMA 052 binds to a unique IL-1 epitope where residues critical for binding have been identified. We have previously reported that XOMA 052 is efficacious in vivo in a diet-induced obesity mouse model thought to be driven by low levels of chronic inflammation. We report here that XOMA 052 also reduces acute inflammation in vivo, neutralizing the effect of exogenously administered human IL-1 and blocking peritonitis in a mouse model of acute gout. Based on its high potency, novel mechanism of action, long half-life, and high affinity, XOMA 052 provides a new strategy for the treatment of a number of inflammatory, autoimmune and metabolic diseases in which the role of IL-1 is central to pathogenesis.
Output: Which molecule is targeted by the drug Gevokizumab?
Facioscapulohumeral muscular dystrophy (FSHD) is a primary muscle disorder with autosomal dominant inheritance. FSHD was mapped to chromosome 4 locus q35, but the gene is not yet known. It is characterised by progressive, often asymmetric, selective muscular weakness and great clinical variability. The aim of the study was to analyze 62 FSHD cases from 44 Polish families in which the diagnosis was confirmed by DNA analyses. FSHD diagnosis was based on the clinical findings and standardized investigations confirming primary muscular involvement (EMG, muscle biopsy). DNA analysis was based on EcoRI/BlnI restriction enzyme digestion followed by hybridization with P13E-11 molecular probe. In our material, we have found a relatively large percentage (41%) of big deletions (EcoRI/BlnI fragment of 10-15 kb [kilo bases]), which in the majority of cases (67%) was present in isolated cases. In 10 families (23%) the phenotype was assessed as severe. These are cases with the onset before the age of 10 and fast progression. "Middle sized" deletions (EcoRI/BlnI fragment of 16-29 kb) were prevalent in familial cases and present in 57% of families. "Small" deletion was found in one family (EcoRI/BlnI fragment of 30 kb). Somatic mosaicism was confirmed in one case. De novo mutations were shown in 11% of the examined families. The results of this study indicate that the bigger the deletion, the more severe the FSHD course, however there are some exceptions. A similar relationship has been shown by previous research. Molecular analyses are particularly important in atypical and sporadic cases. It is the first genetic presentation of a group of patients' with this kind of dystrophy in the Polish population.
Output: What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?
Blackbaud Inc. (NASDAQ:BLKB) is a supplier of software and services specifically designed for nonprofit organizations.
Output: Which stock exchange was Blackbaud affiliated with?
The Saboteur is a neo-noir open world third person action-adventure video game set during World War II in German-occupied France.
Output: Which place is The Saboteur in?
Isabella of France (1295 -- 22 August 1358), sometimes described as the She-Wolf of France, was Queen of England as the wife of Edward II. She was the youngest surviving child and only surviving daughter of Philip IV of France and Joan I of Navarre.
Output: Which lady Isabella of France was born to?
Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
The third and current Aarhus Central Station was built in 1927 by the Danish State Railway's architect K.T. Seest as a part of a plan of the whole area around the station.
Output: When did Aarhus Central Station begin?
Facial expressions carry meaning that is determined by situations and relationships. For example, in American culture the smile is in general an expression of pleasure. Yet it also has other uses. A woman's smile at a police officer does not carry the same meaning as the smile she gives to a young child. A smile may show love or politeness. It can also hide true feelings. It often causes confusion across cultures. For example, many people in Russia smiling at strangers in public to be unusual and even improper. Yet many Americans smile freely at strangers in public places (although this is less common in big cities). Some Russians believe that Americans smile in the wrong places; some Americans believe that Russians don't smile enough. In Southeast Asian culture, a smile is frequently used to cover painful feelings. Vietnamese people may tell a sad story but end the story with a smile. Our faces show emotions, but we should not attempt to "read" people from another culture as we would "read" someone from our own culture. The fact that members of one culture do not express their emotions as openly as do members of another does not mean that they do not experience emotions. Rather, there are cultural differences in the amount of facial expressions permitted. For example, in public and in formal situations many Japanese do not show their emotions as freely as Americans do. When with friends, Japanese and Americans seem to show their emotions similarly. It is difficult to generalize about Americans and facial expressiveness because of personal and cultural differences in the United States. People from certain cultural backgrounds in the United States seem to be more facially expressive than others. The key is to try not to judge people whose ways of showing emotion are different. If we judge according to our own cultural habits, we may make the mistake of "reading" the other person incorrectly.
Output: What would be the best title ?
A joint is a point at which two or more bones meet. There are three main types of joints in the body: 1. Fixed joints do not allow any bone movement. Many of the joints in your skull are fixed ( Figure 1.1). There are eight bones that fuse together to form the cranium. The joints between these bones do not allow movement, which helps protect the brain. 2. Partly movable joints allow only a little movement. Your backbone has partly movable joints between the vertebrae ( Figure 1.2). The skull has fixed joints. Fixed joints do not allow any movement of the bones, which protects the brain from injury. 3. Movable joints allow the most movement. Movable joints are also the most common type of joint in your body. Your fingers, toes, hips, elbows, and knees all provide examples of movable joints. The surfaces of bones at movable joints are covered with a smooth layer of cartilage. The cartilage reduces friction between the bones. Ligaments often cross a joint, holding two nones together. For example, there are numerous ligaments connecting the leg bones across the knee joint. Four types of movable joints are discussed here. 1. In a ball-and-socket joint, the ball-shaped surface of one bone fits into the cup-like shape of another. Exam- ples of a ball-and-socket joint include the hip ( Figure 1.3) and the shoulder. 2. In a hinge joint, the ends of the bones are shaped in a way that allows motion in two directions, forward and backward. Examples of hinge joints are the knees ( Figure 1.4) and elbows. 3. The pivot joint ( Figure 1.5) only allows rotating movement. An example of a pivot joint is the joint between the radius and ulna that allows you to turn the palm of your hand up and down. 4. A gliding joint is a joint which allows only gliding movement. The gliding joint allows one bone to slide over the other. The gliding joint in your wrist allows you to flex your wrist. It also allows you to make very small side-to-side motions. There are also gliding joints in your ankles.
Output: what type of joint allows you to turn the palm of your hand?
The Urban 13 was a research-sharing association originally between thirteen public urban universities, but eventually grew to include 22 institutions when it was succeeded by the Great Cities' Universities coalition in 1998.
Output: Which replaced the Urban 13?
When the order was restored, Murad Pasha marched against Abbas I who was in Tabriz in 1610. Although the two armies met in Accay, north of Tabriz, no engagement or action took place. Due to the problems in the logistics, supply chain and the approaching winter Murad Pasha withdrew his forces to Diyarbakr. While being engaged in diplomatic correspondence with Abbas I for peace and preparing his army for another campaign at the same time he died on 5 August 1611 when he was older than 90. Nasuh Pasha was appointed as the new grand vizier and the commander of the eastern armies. He sued for peace, too, and accepted the proposal of the Safevid side in 1611. The Treaty of Nasuh Pasha was signed on 20 November 1612. The agreement secured the 1555 borders envisaged by the Peace of Amasya. Shah Abbas however, committed himself to send 200 bales of raw silk annually.
Output: Which happened first, Murad marching against Abbas or the signing of the Treaty of Nasuh Pasha?
The pathogenesis of RA is a complex and ever-changing landscape but amid the chaos of the disease process we have found effective treatment regimes. However, our current therapeutics, although targeting various components of both the innate and adaptive immune response, do not result in disease remission. Protein kinase inhibitors are attractive targets due to their ability to influence downstream signalling and their oral bioavailability. Fostamatinib (R788) inhibits spleen tyrosine kinase (Syk) and has been in clinical trials involving both MTX inadequate responders (MTX-IRs) and biologic inadequate responders. Studies on the MTX-IR population revealed ACR20 responses of 67-72% at higher doses (150 mg bd and 100 mg bd), ACR50 responses of 43-57% and ACR70 responses of 28-40%. The trial in the biologic non-responder population showed no efficacy, however, post hoc analyses of the data suggested that a further trial in this population is warranted. The most common adverse events included gastrointestinal effects, hypertension, neutropenia and transaminitis. Many adverse effects were dose responsive and hypertension was amenable to treatment. Upper respiratory tract infections were more likely at higher doses, but no serious infections with tuberculosis, fungi or opportunistic infections were reported. The oral availability of these agents makes them attractive treatment options for our patients, although the literature from the oncology field suggests that patients will only choose the oral route if efficacy is equivalent. Long-term follow-up studies are ongoing and will be critical for rare side effects. The role of these agents in our current arsenal is unclear and economic analyses are awaited.
Output: Which enzyme is inhibited by a drug fostamatinib?
Neurofibroma is a benign tumor that arises from small or large nerves. This neoplastic lesion is a common feature of neurofibromatosis type 1 (NF1), one of the most common autosomal dominant disorders. The NF1 gene codes for a protein called "neurofibromin." It possesses a region that shares a high homology with the family of GTPase-activating proteins, which are negative regulators of RAS function and thereby control cell growth and differentiation. The evidence points to the NF1 gene being a tumor-suppressor gene. NF1 patients also have an increased incidence of certain malignant tumors that are believed to follow the "two hit" hypothesis, with one allele constitutionally inactivated and the other somatically mutated. Recently, somatic loss of heterozygosity (LOH) has been described for neurofibromas, and mutations in both copies of the NF1 gene have been reported for a dermal neurofibroma. The aim of our study was the analysis of the NF1 locus in benign neurofibromas in NF1 patients. We performed LOH analysis on 60 neurofibromas belonging to 17 patients, 9 of them with family history of the disease and 8 of them sporadic. We have analyzed five intragenic NF1 markers and six extragenic markers, and we have found LOH in 25% of the neurofibromas (corresponding to 53% of the patients). In addition, we found that in the neurofibromas of patients from familial cases the deletions occurred in the allele that is not transmitted with the disease, indicating that both copies of the NF1 gene were inactivated in these tumors. Therefore, the recent reports mentioned above, together with our findings, strongly support the double inactivation of the NF1 gene in benign neurofibromas.
Output: Which is the gene mutated in type 1 neurofibromatosis?
Chronic liver injury can result in fibrosis that may progress over years to end-stage liver disease. The most effective anti-fibrotic therapy is treatment of the underlying disease, however when not possible, interventions to reverse or slow fibrosis progression are needed. The aim of this study was to study the safety and tolerability of simtuzumab, a monoclonal antibody directed against lysyl oxidase-like 2 (LOXL2) enzyme, in subjects with hepatitis C virus (HCV), human immunodeficiency virus (HIV), or HCV-HIV co-infection and advanced liver disease. Eighteen subjects with advanced liver fibrosis received simtuzumab 700 mg intravenously every 2 weeks for 22 weeks. Transjugular liver biopsies were performed during screening and at the end of treatment to measure hepatic venous pressure gradient (HVPG) and to stage fibrosis. Treatment was well-tolerated with no discontinuations due to adverse events. No significant changes were seen in HVPG or liver biopsy fibrosis score after treatment. Exploratory transcriptional and protein profiling using paired pre- and post-treatment liver biopsy and serum samples suggested up-regulation of TGF-3 and IL-10 pathways with treatment. In this open-label, pilot clinical trial, simtuzumab treatment was well-tolerated in HCV- and HIV-infected subjects with advanced liver disease. Putative modulation of TGF-3 and IL-10 pathways during simtuzumab treatment merits investigation in future trials.
Output: What is the drug target for Simtuzumab?
With thousands of years of history and mythology in its area, prefix = st1 /Athens--named for the olive-tree-loving Athena---is more than a concrete jungle. It's a lovely city decorated by outdoor cafes, pedestrian streets, parks, gardens and plenty of characters. _ The city is connected three sides by Mt Parnitha, Mt Pendeli and Mt Hymettos. WithinAthensthere are no less than eight hills, of which the Acropolis and Lykavitos are the most famous. The hills provide a peaceful rest from the noise of the city. Just about everything of interest to the traveler is within a small area surrounding Plateia Syntagmatos (Syntagma Square). This area is connected with the districts of Plaka to the south, Monastiraki to the west, Kolonaki to the east and Omaonia to the north. Plateia Syntagmatos is dominated by the oldRoalPalaceand is the beating heart of the business district, with luxury hotels, banks and airline offices. Plaka, nestled below the Acropolis, is the old Turkish quarter and virtually all that existed when Athens was declared the capital of independentGreece. Though Plaka is packed with tourists in high season, it's also one of the prettiest and most atmospheric areas of the city. Monastiraki is the market district and a fascinating part of town to wander. Psiri, nearby, is full of stylish cafes and bars and makes a great place to stop for a rest of lunch. Kolonaki, a classy living area, is full of trendy boutiques, art galleries and cafes.
Output: If you want to buy something, where will you go?
It has been previously shown that disruption of RAD26 in yeast strain W303-1B results in a strain that is deficient in transcription-coupled repair (TCR), the preferential repair of the transcribed strand of an expressed gene over the non-transcribed strand and the rest of the genome. RAD26 encodes a protein that is homologous to Cockayne syndrome group B protein (CSB) and is a member of the SWI2/SNF2 family of DNA-dependent ATPases involved in chromatin remodeling. Like the rad26 mutant, cells from Cockayne syndrome patients are defective in TCR. We examined the role of Rad26 in TCR by disrupting RAD26 in two repair-proficient laboratory strains and, remarkably, observed no effect upon TCR. Our results indicate that disruption of RAD26 alone is insufficient to impair TCR. Thus, W303-1B must already possess a mutation that, together with disruption of RAD26, causes a deficiency in TCR. We suggest that other genes are mutated in Cockayne syndrome cells that contribute to the deficiency in TCR. Surprisingly, deletion of RAD26 results in expression of genes that are repressed by flanking transposon delta elements, an Spt(-) phenotype. The delta elements appear to perturb local chromatin structure. Expression of genes flanked by delta elements in rad26Delta mutants is consistent with a role for Rad26 in chromatin remodeling.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
Disturbance of intracellular trafficking plays a major role in several neurodegenerative disorders including Alzheimer or Parkinson's disease. The Chediak-Higashi syndrome (CHS), a life-threatening autosomal recessive disease with frequent mutations in the LYST gene, and its animal model, the beige mouse, are both characterized by lysosomal defects with accumulation of giant lysosomes. Clinically they manifest as hypopigmentation, abnormal bleeding and increased susceptibility to infection with various degrees of involvement of the nervous system. In the course of a recessive N-ethyl-N-nitrosurea (ENU) mutagenesis screen, we identified the first murine missense mutation in the lysosomal trafficking regulator gene (Lyst(Ing3618)) located at a highly conserved position in the WD40 protein domain. Nearly all described human Lyst alleles lead to protein truncation and fatal childhood CHS. Only four different missense mutations have been reported in patients with adolescent or adult forms of CHS involving the nervous system. Interestingly, the Lyst(Ing3618) model presents with a predominant neurodegenerative phenotype with progressive degeneration and loss of Purkinje cells and lacks severe impairment of the immune system. Therefore, the Lyst(Ing3618 )allele could represent a new model for adult CHS with neurological impairment. It could also provide an important tool to elucidate the role of neuronal lysosomal trafficking in the pathophysiology of neurodegeneration.
Output: Which syndrome is associated with mutations in the LYST gene?
Legislative Studies Quarterly is a quarterly peer-reviewed academic journal published by Wiley-Blackwell and is the official journal of the Legislative Studies Section of the American Political Science Association.
Output: The publisher that published Legislative Studies Quarterly is what?
Bianchi cavalli d'Agosto (internationally known as White Horses of Summer) is a 1975 Italian drama film written and directed by Raimondo Del Balzo.
Output: Who served as director for White Horses of Summer?
Bertuccio Valiero was the son of Silvestro Valiero and Bianca Priuli.
Output: What was Bertuccio Valiero's child's name?