niryuu/sni-each-converted huggingface dataset:
Do you want to visit Disney World? However, will you worry about your pet if you go to Disney World? To meet the needs of these people, a pet hotel has been built near the Disney World Resort in Florida. The new pet hotel is named Best Friends Pet Care Resort and it is mainly open to dogs and cats. It has an area of 4,645m2. About 270 dogs and 30 cats can be kept there at the same time. Besides dogs and cats, it can also provide services for birds, pigs and rabbits. However, it can't take care of snakes and turtles now. Best Friend Pet Care Resort is a very expensive hotel. There are several types of dog rooms, such as rooms with air-conditioners and VIP rooms. There is even a "private dog park". Owners can have a high-quality vacation with their dogs there. The cats are kept in the "Kitty City". The "Kitty City" is very comfortable and clean. Workers there will clean it once a day. Apart from having good equipment, Best Friends Pet Care Resort also have other plans to meet the psychological needs of pets. Workers play music to the pets, walk with them, play with them and even read stories to them before they go to bed. "We aim to make sure that pets will have a fun vacation here, just like their owners at Disney World," said the manager of the resort.
Output: How often do the workers clean the "Kitty City"?
D0g is a fictional character in the Half-Life series of video games, first introduced in Half-Life 2 in 2004.
Output: What fictional work does D0g exist in?
The Battle of Beaune-la-Rolande on 28 November 1870 was a battle of the Franco-Prussian War, won by Prussia.
Output: On what date did Battle of Beaune-la-Rolande occur?
Siltuximab, a chimeric monoclonal antibody with high affinity and specificity for interleukin-6, has been shown to enhance anti-multiple myeloma activity of bortezomib and corticosteroid in vitro. We evaluated the safety, pharmacokinetics, immunogenicity, and antitumor effect of siltuximab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory multiple myeloma. This open-label, phase 1, dose-escalating study used two doses of siltuximab: 5.5 and 11.0 mg/kg (administered on day 1 of each 21-day cycle). In total, nine patients were treated. The most common grade 3/4 adverse events, lymphopenia (89 %) and thrombocytopenia (44 %), occurred in patients receiving both doses of siltuximab; however, no dose-limiting toxicities (DLTs) were observed. Following intravenous administration of siltuximab at 5.5 and 11.0 mg/kg, the maximum serum concentration and the area under the curve from 0 to 21 days and from 0 to infinity increased in an approximately dose-proportional manner. Mean half-life, total systemic clearance, and volume of distribution were similar at doses of 5.5 and 11.0 mg/kg. Across both doses, six of the nine patients had complete or partial response (22 and 44 %, respectively). In conclusion, as no DLT was observed, the recommended dose for this combination is 11.0 mg/kg once every 3 weeks. The study is registered at [Link] as NCT01309412.
Output: Which interleukin is blocked by Siltuximab?
Mutations in the ribosomal protein S19 gene (RPS19) have been found in 25% of patients with Diamond-Blackfan anemia, a rare syndrome of congenital bone marrow failure characterized by erythroblastopenia and various malformations. Mechanistic understanding of the role of RPS19 in normal erythropoiesis and in the Diamond-Blackfan anemia defect is still poor. However, defective ribosome biogenesis and, in particular, impaired 18S ribosomal RNA maturation have been documented in association with various identified RPS19 mutations. Recently, new genes, all encoding ribosomal proteins, have been found to be mutated in Diamond-Blackfan anemia, adding further support to the concept that ribosome biogenesis plays an important role in regulating erythropoiesis. We previously showed variability in the levels of expression and subcellular localization of a subset of RPS19 mutant proteins. To define the mechanistic basis for this variability better, we studied a large number of mutant proteins and characterized both RPS19 expression level using a specific antibody against RPS19 and RPS19 subcellular localization after transfection of Cos-7 cells with various green fluorescent protein-RPS19 mutants. To investigate the role of the proteasome in RPS19 degradation, we examined the effect of various proteasome inhibitors, namely lactacystin, MG132, and bortezomib on RPS19 expression and subcellular localization We found two distinct classes of RPS19 protein defects in Diamond-Blackfan anemia based on the stability of the mutant proteins: (i) slightly decreased to normal levels of expression and normal nucleolar localization and (ii) markedly deficient expression and failure to localize to the nucleolus. All the proteasome inhibitors tested were able to restore the expression levels and normal subcellular localization of several unstable mutant proteins. Our findings demonstrate an important role for the proteasomal degradation pathway in regulating the expression levels and nucleolar localization of certain mutant RPS19 proteins in Diamond-Blackfan anemia.
Output: In which syndrome is the RPS19 gene most frequently mutated?
Lysine 1423 of neurofibromin (neurofibromatosis type I gene product [NF1]) plays a crucial role in the function of NF1. Mutations of this lysine were detected in samples from a neurofibromatosis patient as well as from cancer patients. To further understand the significance of this residue, we have mutated it to all possible amino acids. Functional assays using yeast ira complementation have revealed that lysine is the only amino acid that produced functional NF1. Quantitative analyses of different mutant proteins have suggested that their GTPase-activating protein (GAP) activity is drastically reduced as a result of a decrease in their Ras affinity. Such a requirement for a specific residue is not observed in the case of other conserved residues within the GAP-related domain. We also report that another residue, phenylalanine 1434, plays an important role in NF1 function. This was first indicated by the finding that defective NF1s due to an alteration of lysine 1423 to other amino acids can be rescued by a second site intragenic mutation at residue 1434. The mutation partially restored GAP activity in the lysine mutant. When the mutation phenylalanine 1434 to serine was introduced into a wild-type NF1 protein, the resulting protein acquired the ability to suppress activated phenotypes of RAS2Val-19 cells. This suppression, however, does not involve Ras interaction, since the phenylalanine mutant does not stimulate the intrinsic GTPase activity of RAS2Val-19 protein and does not have an increased affinity for Ras proteins.
Output: Which is the gene mutated in type 1 neurofibromatosis?
The Rams started their season on the road against the Lions. The Rams drew first blood in the first quarter with a 48-yard field goal from Greg Zuerlein to take a 3-0 lead for the only score of that quarter. The Lions then took a 7-3 lead with Joique Bell's 1-yard run for a touchdown in the 2nd quarter. The Rams responded with a 29-yard field goal from Zuerlein as they came up within a point 7-6 before on the Lions' next possession, Matthew Stafford was picked off by Cortland Finnegan and it was returned 31 yards for a touchdown as the Rams retook the lead 13-7. The Lions then responded with Jason Hanson kicking a 41-yard field goal to shorten the Rams' lead to 13-10 at halftime. After the break, the Lions scored first with Jason Hanson kicking a 45-yard field goal to tie the game 13-13 for the only score of the 3rd quarter. However, the Rams moved back into the lead in the 4th quarter with Brandon Gibson's 23-yard catch from Sam Bradford to make it 20-13. The Lions tied the game back up with Kevin Smith running for a touchdown from 5 yards out to tie the game 20-20. The Rams then retook the lead with Greg Zuerlein kicking a 46-yard field goal to make the score 23-20. On their last possession, the Lions moved down the field and Matthew Stafford found Kevin Smith on a 5-yard touchdown pass to make the final score 27-23 as the Rams began their season 0-1.
Output: Who kicked the longest field goal in the last quarter?
Corsair Components, Inc. is an American computer peripherals and hardware company headquartered in Fremont, California.
Output: Which city is Corsair Components located in?
Imatinib mesylate is the sole BCR-ABL tyrosine kinase inhibitor approved as first-line treatment of accelerated-phase (AP) chronic myeloid leukemia (CML). Indication was based on the STI571 0109 study, in which imatinib favorably compared to historical treatments in patients failing prior therapies. The relevance of these results to currently newly diagnosed AP-CML patients remains unknown. We evaluated the benefit of imatinib in 42 newly diagnosed AP-CML patients. In all, 16 patients had hematological acceleration without chromosomal abnormalities in addition to the Philadelphia chromosome (ACAs; HEM-AP), 16 solely had ACAs (ACA-AP) and 10 had hematological acceleration plus ACAs (HEM-AP + ACA). Major cytogenetic responses were achieved in 93.7% of HEM-AP patients, 75% of patients with ACA-AP (P=NS) and 40% of patients with HEM-AP + ACA (P=0.0053). The 24-month failure-free survival rate was 87.5% in HEM-AP patients, 43.8% in ACA-AP patients and 15% in HEM-AP + ACA patients (P=0.022). The 24-month estimate of progression-free survival was 100% in HEM-AP patients, 92.8% in ACA-AP patients and 58.3% in HEM-AP + ACA patients (P=0.0052). In conclusion, frontline imatinib allows favorable outcomes in HEM-AP and ACA-AP patients but appears insufficient for patients with HEM-AP + ACA. Broader-target and/or more potent BCR-ABL tyrosine kinase inhibitors alone or in combination may be considered in this setting.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
The immune system usually protects you from pathogens and other causes of disease. When the immune system is working properly, it keeps you from getting sick. But the immune system is like any other system of the body. It can break down or develop diseases. AIDS is an infectious disease of the immune system caused by a virus. Some diseases of the immune system are noninfectious. They include autoimmune diseases and allergies. Does it make sense for an immune system to attack the cells it is meant to protect? No, but an immune system that does not function properly will attack its own cells. An autoimmune disease is a disease in which the immune system attacks the bodys own cells. One example is type 1 diabetes. In this disease, the immune system attacks cells of the pancreas. Other examples are multiple sclerosis and rheumatoid arthritis. In multiple sclerosis, the immune system attacks nerve cells. This causes weakness and pain. In rheumatoid arthritis, the immune system attacks the cells of joints. This causes joint damage and pain. Autoimmune diseases cannot be cured. But they can be helped with medicines that weaken the immune systems attack on normal cells. Other autoimmune diseases include celiac disease (damages to the small intestine), inflam- matory bowel disease (damage to the digestive tract), psoriasis (damage to the skin), and lupus (damage to the joints, skin, kidneys, heart, and lungs). An allergy occurs when the immune system attacks a harmless substance that enters the body from the outside. A substance that causes an allergy is called an allergen. It is the immune system, not the allergen, that causes the symptoms of an allergy. Did you ever hear of hay fever? Its not really a fever at all. Its an allergy to plant pollens. People with this type of allergy have symptoms such as watery eyes, sneezing, and a runny nose. A common cause of hay fever is the pollen of ragweed. Many people are also allergic to poison ivy ( Figure 1.2). Skin contact with poison ivy leads to an itchy rash in people who are allergic to the plant. Ragweed is a common roadside weed found throughout the United States. Many people are allergic to its pollen. Some people are allergic to certain foods. Nuts and shellfish are common causes of food allergies. Other common causes of allergies include: Drugs, such as penicillin. Mold. Dust. The dead skin cells of dogs and cats, called dander. Stings of wasps and bees. Most allergies can be treated with medicines. Medicines used to treat allergies include antihistamines and corticos- teroids. These medicines help control the immune system when it attacks an allergen. Sometimes, allergies cause severe symptoms, a condition known as anaphylaxis. For example, they may cause the throat to swell so it is hard to breathe. Severe allergies may be life threatening. They require emergency medical care.
Output: hay fever is an allergy to
An inheritable bleeding disorder with light coat color caused by an autosomal recessive gene has been reported in a population of Japanese black cattle. The disease has been diagnosed as Chediak-Higashi Syndrome (CHS) of cattle which correspond to a human inheritable disorder caused by mutation in LYST gene. To characterize the molecular lesion causing CHS in cattle, cDNAs encoding bovine LYST were isolated from a bovine brain cDNA library. The nucleotide and deduced amino acid sequences of bovine LYST had 89.6 and 90.2% identity with those of the human LYST gene, respectively. In order to identify the mutation within the LYST gene causing CHS in cattle, cDNA fragments of the LYST gene were amplified from an affected animal by RT-PCR and their nucleotide sequences were completely determined. Notably, a nucleotide substitution of A to G transition, resulting in an amino acid substitution of histidine to arginine (H2015R) was identified in the affected animal. The presence of the substitution was completely corresponding with the occurrence of the CHS phenotype among 105 members of pedigrees of the Japanese black cattle and no cattle of other populations had this substitution. These findings strongly suggested that H2015R is the causative mutation in CHS of Japanese black cattle.
Output: Which syndrome is associated with mutations in the LYST gene?
Despite the Portuguese proclaiming themselves as hostile to the Spanish crown, the VOC nevertheless took the opportunity to prise away the string of coastal fortresses that comprised the Portuguese Empire: Malacca finally succumbed in 1641. Important battles also took place in the South China sea, initially with combined fleets of Dutch and English vessels, and subsequently exclusively Dutch ships assaulting Macau. Dutch attempts to capture Macau, to force China to replace the Portuguese or to settle the Pescadores failed, in part because of the long-standing diplomacy between the Portuguese and the Ming, but the Dutch were ultimately successful in acquiring the monopoly of trade with Japan. while the Dutch were unable in four attempts to capture Macau from where Portugal monopolised the lucrative China-Japan trade. The Dutch established a colony at Tayouan in 1624, present-day Anping in the south of Taiwan, known to the Portuguese as Formosa and in 1642 the Dutch took northern Formosa from the Spanish by force. The Dutch intervened in the Sinhalese-Portuguese War on Ceylon from 1638 onwards, initially as allies of the Kingdom of Kandy against Portugal. The Dutch conquered Batticaloa in 1639 and Galle in 1640 before the alliance broke down. After a period of triangular warfare between the Dutch, Portuguese and Kandyans, the alliance was remade in 1649. After exploiting and then double-crossing their Kandyan allies, the Dutch were able to capture Colombo in 1656 and drove the last Portuguese from Ceylon in 1658. Sporadic warfare with Kandy continued for over a century.
Output: Which European power were the Dutch attempting to take territory from before launching their assault on Spanish territory?
Antonio Gates caught three touchdowns from Rivers to lead the Chargers to a 30-21 win over the defending Super Bowl champion Seattle Seahawks. San Diego held a 42:15 to 17:45 advantage in time of possession under hot weather conditions. The official game-time temperature was 94F (34C), while readings at field level read closer to 115F (46C). The Chargers had six drives of eight plays or moreincluding possessions of 14, 12, and 10 playswhile the Seahawks had one eight-play drive. San Diego's first possession was a 14-play drive that led to a 50-yard field goal by Nick Novak, ending the Seahawks' 20-game streak without allowing a score on the opening possession. Following a 10-play field goal drive by the Chargers in the second quarter, linebacker Kavell Conner forced a fumble on the kickoff, which led to a six-play touchdown drive; the two drives combined to keep the Seahawks offense off the field for almost nine minutes. Gates' third touchdown came after he split two defenders and made a spectacular one-handed grab to give the Chargers a 27-14 lead late in the third quarter. Rivers was 28-of-37 for 284 yards. He had thrown 65 touchdowns to Gates, the most between a quarterback and tight end in NFL history. The Chargers were 10-for-17 on third-down conversions, while the Seahawks were 3-for-8.
Output: Which team had the most third-down conversions Chargers or Seahawks?
Chediak-Higashi syndrome, a rare autosomal recessive disorder, was described over 50 years ago. Patients show hypopigmentation, recurrent infections, mild coagulation defects and varying neurologic problems. Treatment is bone marrow transplant, which is effective in treating the hematologic and immune defects, however the neurologic problems persist. The CHS1/LYST gene was identified over 10 years ago and homologous CHS1/LYST genes are present in all eukaryotes. This review will discuss the advances made in understanding the clinical aspects of the syndrome and the function of CHS1/LYST/Beige. Clinical reports of Chediak-Higashi syndrome have identified mutations throughout the CHS1/LYST gene. The nature of the mutation can be a predictor of the severity of the disease. Over the past decade the CHS1/LYST family of proteins has been analyzed using model organisms, two-hybrid analysis, overexpression phenotypes and dominant negatives. These studies suggest that the CHS1/LYST protein is involved in either vesicle fusion or fission. Although CHS is a rare disease, the Chediak-like family of proteins is providing insight into the regulation of vesicle trafficking. Understanding the basic mechanisms that govern vesicle trafficking will provide essential information regarding how loss of CHS1/LYST affects hematologic, immunologic and neurologic processes.
Output: Which syndrome is associated with mutations in the LYST gene?
There are two basic types of cells, prokaryotic cells and eukaryotic cells. The main difference between eukaryotic and prokaryotic cells is that eukaryotic cells have a nucleus. The nucleus is where cells store their DNA, which is the genetic material. The nucleus is surrounded by a membrane. Prokaryotic cells do not have a nucleus. Instead, their DNA floats around inside the cell. Organisms with prokaryotic cells are called prokaryotes. All prokaryotes are single-celled (unicellular) organisms. Bacteria and Archaea are the only prokaryotes. Organisms with eukaryotic cells are called eukaryotes. Animals, plants, fungi, and protists are eukaryotes. All multicellular organisms are eukaryotes. Eukaryotes may also be single-celled. Both prokaryotic and eukaryotic cells have structures in common. All cells have a plasma membrane, ribosomes, cytoplasm, and DNA. The plasma membrane, or cell membrane, is the phospholipid layer that surrounds the cell and protects it from the outside environment. Ribosomes are the non-membrane bound organelles where proteins are made, a process called protein synthesis. The cytoplasm is all the contents of the cell inside the cell membrane, not including the nucleus. Eukaryotic cells usually have multiple chromosomes, composed of DNA and protein. Some eukaryotic species have just a few chromosomes, others have close to 100 or more. These chromosomes are protected within the nucleus. In addition to a nucleus, eukaryotic cells include other membrane-bound structures called organelles. Organelles allow eukaryotic cells to be more specialized than prokaryotic cells. Pictured below are the organelles of eukaryotic cells ( Figure 1.1), including the mitochondria, endoplasmic reticulum, and Golgi apparatus. These will be discussed in additional concepts. DNA (chromatin) is stored. Organelles give eukaryotic cells more functions than prokaryotic cells. Prokaryotic cells ( Figure 1.2) are usually smaller and simpler than eukaryotic cells. They do not have a nucleus or other membrane-bound organelles. In prokaryotic cells, the DNA, or genetic material, forms a single large circle that coils up on itself. The DNA is located in the main part of the cell. Nucleus DNA Membrane-Bound Organelles Examples Prokaryotic Cells No Single circular piece of DNA No Bacteria Eukaryotic Cells Yes Multiple chromosomes Yes Plants, animals, fungi
Output: all cells have a __________________________________
Sven Gerich The information up to 2007 was retrieved from Die Wiesbadener Oberburgermeister seit dem Bau des neuen Rathauses (1886) (The Wiesbaden Mayors since the construction of the new town mayor hall (1886) )
Output: Who became the leader of Wiesbaden?
Tick-Tock appeared as part of the ''Night Shift'' entry in the Official Handbook of the Marvel Universe Update '89 #5.
Output: In which fictional universe does Tick-Tock exist?
Cornelia de Lange syndrome (CdLS), a disorder caused by mutations in cohesion proteins, is characterized by multisystem developmental abnormalities. PDS5, a cohesion protein, is important for proper chromosome segregation in lower organisms and has two homologues in vertebrates (PDS5A and PDS5B). Pds5B mutant mice have developmental abnormalities resembling CdLS; however the role of Pds5A in mammals and the association of PDS5 proteins with CdLS are unknown. To delineate genetic interactions between Pds5A and Pds5B and explore mechanisms underlying phenotypic variability, we generated Pds5A-deficient mice. Curiously, these mice exhibit multiple abnormalities that were previously observed in Pds5B-deficient mice, including cleft palate, skeletal patterning defects, growth retardation, congenital heart defects and delayed migration of enteric neuron precursors. They also frequently display renal agenesis, an abnormality not observed in Pds5B(-/-) mice. While Pds5A(-/-) and Pds5B(-/-) mice die at birth, embryos harboring 3 mutant Pds5 alleles die between E11.5 and E12.5 most likely of heart failure, indicating that total Pds5 gene dosage is critical for normal development. In addition, characterization of these compound homozygous-heterozygous mice revealed a severe abnormality in lens formation that does not occur in either Pds5A(-/-) or Pds5B(-/-) mice. We further identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a familial case of CdLS, in which affected individuals also develop megacolon. This study shows that PDS5A and PDS5B functions other than those involving chromosomal dynamics are important for normal development, highlights the sensitivity of key developmental processes on PDS5 signaling, and provides mechanistic insights into how PDS5 mutations may lead to CdLS.
Output: Which syndrome is caused by deletion of Pds5b in mice?
Selective serotonin reuptake inhibitors (SSRIs) are first-line treatments for posttraumatic stress disorder (PTSD). Serotonergic (5HT) attenuation of stress sensitivity is postulated from SSRIs' effects in other anxiety disorders, and we studied this in PTSD. Ten patients with PTSD fully recovered on SSRIs (Clinical Global Impression Scale-I 1 and 2) were enrolled in the study. Patients were tested on two occasions 1 week apart; in each session, they received a drink containing large neutral amino acids (LNAAs) either with (sham tryptophan depletion [STD], control) or without (acute tryptophan depletion [ATD]) tryptophan. At 5.5 hours after the drink, subjects were exposed to a trauma-related exposure challenge. Self-reports of PTSD (visual analogue scales [VAS] and the Davidson Trauma Scale [DTS]), anxiety (Spielberger State Inventory [STAI] Form Y-1), and mood (Profile of Mood States [POMS]) were obtained. Heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure were also measured. The trauma-related exposure challenge induced anxiety on both days, with more marked responses on the ATD day according to VAS, DTS, POMS, and DBP (p < .05). A trend of significance (.1 > p > .05) was observed for STAI Form Y-1, HR, and SBP. These data demonstrate that ATD accentuates responses to trauma-related stimuli in SSRI-recovered PTSD. They also suggest that SSRI-induced increases in serotonin function restrain PTSD symptoms, especially under provocation, supporting a role for serotonin in mediating stress resilience.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
FORBES CHINA's annual celebrity list is based on income and appearances in magazines, newspapers, TV shows and online. Stars from the mainland, Taiwan and Hong Kong are included. And here are some of the winners: Jay Chou Taiwan singer, actor and director unveiled his 12th studio album, Opus 12, last December (Another "12''). New flick in the works: The Rooftop, being filmed in Taiwan and the mainland, which he stars in and also directs. 3. Andy Lau Now in his 50s, the evergreen Hong Kong star of song and film stayed popular last year with the movie Blind Detective. Lau's sixth film with Hong Kong actress Sammi Cheng is in the works. Jackie Chan Hong Kong movie industry icon last year released what may be his last action film CZ12, or Chinese Zodiac, which he wrote and directed. 5. Zhang Ziyi Popular actress had hit romantic comedy last year with My Lucky Star, which she also produced. Appears in this year's star-laden The Grandmaster kung fu movie, directed by Hong Kong's Wong Kar-Wai and also starring Tony Leung. 7. Yang Mi Actress was named most popular female singer in mainland China last year in a joint CCTV-MTV event. Last year's flicks included Love in the Buff, Beijing Love Story and Wu Dang. Has endorsement deals with Pepsi and cosmetics brand Wetcode. 8. Huang Xiaoming Actor turned up in several successful films last year, including Love in the Buff, An Inaccurate Memoir and White-Haired Witch. Promotes Baleno, Tissot, Olay. 10. Lin Chi-ling Taiwan TV hostess, model and actress. Most recent success: romantic comedy Say Yes, which took in more than $30 million in China.
Output: Who is the director of the Grandmaster ?
Erythrasma is a superficial cutaneous infection caused by Corynebacterium minutissimum and is characterized by fluorescence under Wood's light (UV) because of the presence of porphyrins. These molecules are photosensitizing and we propose to assess efficacy of red light that activates porphyrins (photodynamic reaction) in treatment of this pathology. Assessment of effects of photodynamic action of red light for treatment of erythrasma without exogenous photosensitizing molecules. Thirteen patients with erythrasma were treated by one illumination (80 J/cm2) by red light (broad band, peak at 635 nm) without exogenous photosensitizing molecules. Disappearance or reduction of extent of lesions were observed 2 weeks later. If lesions were still present, a second irradiation was conducted with the same method. Preliminary results are presented. As a result of red light irradiation, we noticed a complete recovery for three patients and, in most other cases, reduction of extent of lesions (mean: -29% after one session). The treatment was well tolerated. We report first cases of photodynamic treatment of erythrasma. There are other reports of clinical applications of antimicrobial action of photodynamic therapy in dermatology (acne vulgaris, leishmaniasis, warts, etc.). But there are few applications without addition of exogenous photosensitizing agent. The originality and interest of our study is to use spontaneous presence of porphyrins in the lesions. This technique seems to be an interesting alternative, inexpensive and easy, for the treatment of this localized infection. But an optimal method is still to be determined to improve efficacy.
Output: Which bacteria causes erythrasma?
The complex expression patterns observed for many genes are often regulated by distal transcription enhancers. Changes in the nucleotide sequences of enhancers may therefore lead to changes in gene expression, representing a central mechanism by which organisms evolve. With the development of the experimental technique of chromatin immunoprecipitation (ChIP), in which discrete regions of the genome bound by specific proteins can be identified, it is now possible to identify transcription factor binding events (putative cis-regulatory elements) in entire genomes. Comparing protein-DNA binding maps allows us, for the first time, to attempt to identify regulatory differences and infer global patterns of change in gene expression across species. Here, we review studies that used genome-wide ChIP to study the evolution of enhancers. The trend is one of high divergence of cis-regulatory elements between species, possibly compensated by extensive creation and loss of regulatory elements and rewiring of their target genes. We speculate on the meaning of the differences observed and discuss that although ChIP experiments identify the biochemical event of protein-DNA interaction, it cannot determine whether the event results in a biological function, and therefore more studies are required to establish the effect of divergence of binding events on species-specific gene expression.
Output: Are human enhancers or promoters evolving faster?
The name Bihar is derived from the Sanskrit and Pali word, Vihara (Devanagari: ), which means ''abode''.
Output: The Bihar was named for whom?
Driving In America Keep Right The traffic follows the "keep right rule". While driving, drive on the right side of the road. On one-way, multiple lanes road, the right-most lane would be slowest and left-most lane is fastest. Hand Signals Though indicators are used for the purpose of showing which direction you are going, knowing some hand signals is very important and are usually always asked in a driving test. When you want to turn right, you can put your left hand out of the window and point upward. When you want to make a left turn, you can reach your left arm out of the window and point to the left. If you want to slow down or stop, you can just point downward. School Buses Yellow school buses have flashing red lights and stop signs that reach out from the driver's side. The drivers use these warning signals when letting pupils on and off. No matter which side of the road you are traveling on, if you come upon a school bus with its lights flashing and a stop sign used, you must stop. It's the law. Remain stopped until the lights stop flashing or the stop sign is removed. Using the Horn Using horns is not common in America. Actually they are very rarely used. You may use your horn to warn walkers or other drivers of possible trouble or to avoid accidents. Do not use your horn to express anger or complain about other drivers' mistakes or to try to get a slow driver to move faster.
Output: Who is the passage most probably written for?
The Redskins scored the first points of the game when Shaun Suisham kicked a 31-yard field goal in the second quarter. On the last play of the 1st half, Trent Green threw a 1-yard pass to Justin Peelle to claim the lead. The Redskins started the third quarter with Clinton Portis running for a 19-yard touchdown. Miami later answered with a field goal to tie the game. In the 4th quarter, both teams scored a field goal and the game went into overtime. Washington won the coin toss. They ran the ball down to Miami's 22-yardline, and Shaun Suisham made a game-winning 39-yard field goal. Clinton Portis finished the game with 17 carries, 98 yards, and a touchdown. The Redskins lost right tackle Jon Jansen for the year when he fractured his ankle in the second quarter. GameBook
Output: Which player scored the last points?
In humans, the gene FANCA is 79 kilobases (kb) in length, and is located on chromosome 16 (16q24.3).
Output: What is the name of the chromosome where you can find FANCA?
Adam Park is a fictional major character from the universe of the American television series franchise Power Rangers, played by Johnny Yong Bosch.
Output: To which fictional work does Adam Park belong in?
Beloved Infidel is a 1959 DeLuxe Color biographical drama film made by 20th Century Fox CinemaScope and based on the life of F. Scott Fitzgerald.
Output: What was the production company for Beloved Infidel?
You dont have to be an ice climber to enjoy ice. Skating and fishing are two other sports that are also done on ice. What is ice? Its simply water in the solid state. The process in which water or any other liquid changes to a solid is called freezing. Freezing occurs when a liquid cools to a point at which its particles no longer have enough energy to overcome the force of attraction between them. Instead, the particles remain in fixed positions, crowded closely together, as shown in the Figure 1.1. The temperature at which a substance freezes is known as its freezing point. Freezing point is a physical property of matter. The freezing point of pure water is 0 C. Below this temperature, water exists as ice. Above this temperature, it exists as liquid water or water vapor. Many other substances have much lower or higher freezing points than water. You can see some examples in the Table 1.1. The freezing point of pure water is included in the table for comparison. Substance Helium Oxygen Nitrogen Pure Water Lead Iron Carbon Freezing Point ( C) -272 -222 -210 0 328 1535 3500 Q: What trend do you see in this table? A: Substances in the table with freezing points lower than water are gases. Substances in the table with freezing points higher than water are solids. Q: Sodium is a solid at room temperature. Given this information, what can you infer about its freezing point? A: You can infer that the freezing point of sodium must be higher than room temperature, which is about 20 C. The freezing point of sodium is actually 98 C.
Output: which of these substances has the highest freezing point?
Very Rev. Tadeusz Brzozowski, S.J. (October 21, 1749 -- February 5, 1820) was a Polish Jesuit, elected 19th Superior General of the Society of Jesus.
Output: What group was Tadeusz Brzozowski a member of?
Lake Forest High School Clubs Environmental Club Club members are provided opportunities to realize their goals of environmental service. The majority of projects are student-initiated. Last year's activities included: the LFHS Courtyard Garden upkeep, Bike to School Day with free cocoa and snacks, an "eat local" 100-mile dinner, recycling solutions for LFHS, beach cleanup through the Great Lakes Alliance, and Earth Week celebrations. Meetings: First Friday of the month in Room 5 at 7:00 a.m. Advisor: Ms Mary Beth Nawor, _ Peer Tutoring Students volunteer to help fellow students in improving their academic and organizational skills. Students tutor LFHS and middle school students on an individually scheduled basis. LFHS tutors must have proficiency in the academic area in which they wish to tutor, but middle school tutors only need general academic proficiency. Meetings: All tutoring is done on an individually scheduled basis. Advisor: Ms Kathy O'Hara, _ Young Idea Young Idea is LFHS's art and literary magazine. Students of all ages who love writing and art are encouraged to become part of the staff of this award-winning magazine. Young Idea encourages all students to submit art and literature works to the magazine, whether they are a part of the staff or not. From September to February, Young Idea meets on Thursdays after school in the Public Room to discuss the pieces that have been submitted to the magazine and provide feedback for the authors. Meetings: See above explanation. Advisor: Ms Debbie Zare, _ Scout Buddies Scout Buddies is a friendship club which helps build friendship among individuals with and without disabilities. Club members participate in a variety of social activities both within the school and in the community. Activities include organizing holiday parties in the school, bowling, going to the movies, and eating out in local restaurants. Meetings: Monthly meeting dates vary, but in Room 134. Advisor: Ms Donna Lovitsch, _
Output: Which club provides help for students poor in study?
Anne de Bourbon (1380 -- September 1408) was a daughter of John I, Count of La Marche and his wife Catherine of Vendome.
Output: Who was Anne de Bourbon's father?
Although ultrasound measurements have been used in previous studies on carpal tunnel syndrome to visualize injury to the median nerve, whether such ultrasound data can indicate the severity of carpal tunnel syndrome remains controversial. The cross-sectional areas of the median nerve at the tunnel inlet and outlet can show swelling and compression of the nerve at the carpal. We hypothesized that the ratio of the cross-sectional areas of the median nerve at the carpal tunnel inlet to outlet accurately reflects the severity of carpal tunnel syndrome. To test this, high-resolution ultrasound with a linear array transducer at 5-17 MHz was used to assess 77 patients with carpal tunnel syndrome. The results showed that the cut-off point for the inlet-to-outlet ratio was 1.14. Significant differences in the inlet-to-outlet ratio were found among patients with mild, moderate, and severe carpal tunnel syndrome. The cut-off point in the ratio of cross-sectional areas of the median nerve was 1.29 between mild and more severe (moderate and severe) carpal tunnel syndrome patients with 64.7% sensitivity and 72.7% specificity. The cut-off point in the ratio of cross-sectional areas of the median nerve was 1.52 between the moderate and severe carpal tunnel syndrome patients with 80.0% sensitivity and 64.7% specificity. These results suggest that the inlet-to-outlet ratio reflected the severity of carpal tunnel syndrome.
Output: What nerve is involved in carpal tunnel syndrome?
Sedimentary rocks follow certain rules. 1. Sedimentary rocks are formed with the oldest layers on the bottom and the youngest on top. 2. Sediments are deposited horizontally, so sedimentary rock layers are originally horizontal, as are some vol- canic rocks, such as ash falls. 3. Sedimentary rock layers that are not horizontal are deformed. Since sedimentary rocks follow these rules, they are useful for seeing the effects of stress on rocks. Sedimentary rocks that are not horizontal must have been deformed. You can trace the deformation a rock has experienced by seeing how it differs from its original horizontal, oldest- on-bottom position. This deformation produces geologic structures such as folds, joints, and faults that are caused by stresses. Youre standing in the Grand Canyon and you see rocks like those in the Figure 1.1. Using the rules listed above, try to figure out the geologic history of the geologic column. The Grand Canyon is full mostly of sedimentary rocks, which are important for deciphering the geologic history of a region. In the Grand Canyon, the rock layers are exposed like a layer cake. Each layer is made of sediments that were deposited in a particular environment - perhaps a lake bed, shallow offshore region, or a sand dune. (a) The rocks of the Grand Canyon are like a layer cake. (b) A geologic column showing the rocks of the Grand Canyon. In this geologic column of the Grand Canyon, the sedimentary rocks of groups 3 through 6 are still horizontal. Group 2 rocks have been tilted. Group 1 rocks are not sedimentary. The oldest layers are on the bottom and youngest are on the top. The ways geologists figure out the geological history of an area will be explored more in the chapter Earth History. Click image to the left or use the URL below. URL:
Output: the classic location to see layer cake geology is
Dr. Suhas Patil founded the company as ''Patil Systems, Inc.'' in Salt Lake City in 1981; it adopted the name ''Cirrus Logic'' when it moved to Silicon Valley in 1984.
Output: Which person is involved in the founding of Cirrus Logic?
The median income for a household in the city in 2000 was $29,378 (2010$37,436), and the median income for a family was $41,158. Males had a median income of $32,929 versus $26,856 for females. The per capita income for the city was $17,076. About 20.2% of families and 25.9% of the population were below the poverty line, including 41.5% of those under age 18 and 5.6% of those age 65 or over.
Output: Which age group has the highest percentage of being below the poverty line, 65 or over or under age 18?
FK506 binding protein 6, also known as FKBP6, is a human gene.
Output: In what living being can FKBP6 be found?
Accumulation and deposition of -amyloid peptides (A) in the brain is a central event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology, A is known to undergo active transport across the blood-brain barrier and cerebral amyloid angiopathy (CAA) is a prominent feature in the majority of AD. Although impaired cerebral blood flow (CBF) has been implicated in faulty A transport and clearance, and cerebral hypoperfusion can exist in the pre-clinical phase of Alzheimer's disease (AD), it is still unclear whether it is one of the causal factors for AD pathogenesis, or an early consequence of a multi-factor condition that would lead to AD at late stage. To study the potential interaction between faulty CBF and amyloid accumulation in clinical-relevant situation, we generated a new amyloid precursor protein (APP) knock-in allele that expresses humanized A and a Dutch mutation in addition to Swedish/London mutations and compared this line with an equivalent knock-in line but in the absence of the Dutch mutation, both crossed onto the PS1M146V knock-in background. Introduction of the Dutch mutation results in robust CAA and parenchymal A pathology, age-dependent reduction of spatial learning and memory deficits, and CBF reduction as detected by fMRI. Direct manipulation of CBF by transverse aortic constriction surgery on the left common carotid artery caused differential changes in CBF in the anterior and middle region of the cortex, where it is reduced on the left side and increased on the right side. However these perturbations in CBF resulted in the same effect: both significantly exacerbate CAA and amyloid pathology. Our study reveals a direct and positive link between vascular and parenchymal A; both can be modulated by CBF. The new APP knock-in mouse model recapitulates many symptoms of AD including progressive vascular and parenchymal A pathology and behavioral deficits in the absence of APP overexpression.
Output: Which disease the London mutation involved in?
Prismatomeris andamanica is a critically endangered species of plant in the Rubiaceae family.
Output: What level is Prismatomeris andamanica's iucn conservation status?
In 1998, W.H. Brady Co. became Brady Corporation and in 1999, the company began trading on the New York Stock Exchange under ticker symbol BRC.
Output: Which exchange is Brady Corporation listed with?
Charlie was spending his summer holidays by the sea. One day he climbed over some rocks. He was looking for some crabs for supper. He took off his shorts and put them on a rock. The afternoon went quickly. Time was flying by. Look! The sea was coming in fast. It was over some of the rocks now. Charlie looked up. "It's getting late. Oh dear! Look at the sea. Where are my shorts now?" he thought. He saw them on a rock. Oh dear! The rock was an island! Now he must swim and got them. Charlie jumped into the sea and started swimming. He reached the rock and put his shorts on his head. Then he started swimming back. Oh no! The sea was too strong for Charlie. It was pulling him away from the beach. "Help!" he called. "I can't get back. " Luckily, a boat was coming by. The people in the boat saw Charlie and heard his call for help. "Are you all right?" asked the woman in the boat. "No! I can't swim back. The sea is too strong. " The woman stopped the boat and she and a girl pulled Charlie into the boat. He threw his shorts into the boat too. Then they turned the boat Bound and took Charlie back to the beach. "That was lucky," said the woman. "Thank you very much," said Charlie. "Be careful next time," said the woman. "The sea is usually very strong near these rocks. " "Next time, I'm going to keep my shorts in my bag," said Charlie. "Better safe than sorry!"
Output: Where did the story take place?
Coming off their hard-fought road win over the Titans, the Texans went home, donned their Battle Red uniforms, and prepared for a Week 3 AFC South showdown with the Jacksonville Jaguars. Even though the Jaguars got the first points of the game with kicker Josh Scobee's 52-yard field goal, Texans quarterback Matt Schaub got his team the lead with an 18-yard touchdown pass to wide receiver Jacoby Jones. Afterwards, a back-and-forth second quarter commenced. Jacksonville quarterback David Garrard would get a 2-yard touchdown, yet Houston wide receiver Kevin Walter came through with a 9-yard touchdown reception. The Jaguars would deliver a big strike with running back Maurice Jones-Drew's 61-yard touchdown, but the Texans once again got the lead as tight end Owen Daniels got a 2-yard touchdown reception. Jacksonville would get the lead again in the third quarter as Jones-Drew got a 1-yard touchdown run, followed by Houston kicker Kris Brown tying the game with a 27-yard field goal. However, in the fourth quarter, the Jaguars delivered a huge strike as Jones-Drew got an 8-yard touchdown. The Texans tried to rally, but the Jaguars' defense stood firm and prevented any kind of a comeback.
Output: Which player scored the most touchdowns?
Just under two years after announcing his retirement, Krzysztof Kieslowski died on 13 March 1996 at age 54 during open-heart surgery following a heart attack, and was interred in Powazki Cemetery in Warsaw.
Output: The final resting place of Krzysztof Kieślowski is at what cemetery?
Selenium (Se) is an essential trace element for several organisms and is present in proteins as selenocysteine (Sec or U), an amino acid that is chemically distinct from serine and cysteine by a single atom (Se instead of O or S, respectively). Sec is incorporated into selenoproteins at an in-frame UGA codon specified by an mRNA stem-loop structure called the selenocysteine incorporating sequence (SECIS) presented in selenoprotein mRNA and specific selenocysteine synthesis and incorporation machinery. Selenoproteins are presented in all domains but are not found in all organisms. Although several functions have been attributed to this class, the majority of the proteins are involved in oxidative stress defense. Here, we discuss the kinetoplastid selenocysteine pathway and how selenium supplementation is able to alter the infection course of trypanosomatids in detail. These organisms possess the canonical elements required for selenoprotein production such as phosphoseryl tRNA kinase (PSTK), selenocysteine synthase (SepSecS), selenophosphase synthase (SelD or SPS), and elongation factor EFSec (SelB), whereas other important factors presented in mammal cells, such as SECIS binding protein 2 (SBP) and SecP 43, are absent. The selenoproteome of trypanosomatids is small, as is the selenoproteome of others parasites, which is in contrast to the large number of selenoproteins found in bacteria, aquatic organisms and higher eukaryotes. Trypanosoma and Leishmania are sensitive to auranofin, a potent selenoprotein inhibitor; however, the probable drug mechanism is not related to selenoproteins in kinetoplastids. Selenium supplementation decreases the parasitemia of various Trypanosome infections and reduces important parameters associated with diseases such as anemia and parasite-induced organ damage. New experiments are necessary to determine how selenium acts, but evidence suggests that immune response modulation and increased host defense against oxidative stress contribute to control of the parasite infection.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?