niryuu/sni-each-converted huggingface dataset:
Extrusive igneous rocks cool at the surface. Volcanoes are one type of feature that forms from extrusive rocks. Several other interesting landforms are also extrusive features. Intrusive igneous rocks cool below the surface. These rocks do not always remain hidden. Rocks that formed in the crust are exposed when the rock and sediment that covers them is eroded away. When lava is thick, it flows slowly. If thick lava makes it to the surface, it cannot flow far from the vent. It often stays right in the middle of a crater at the top of a volcano. Here the lava creates a large, round lava dome (Figure A lava plateau is made of a large amount of fluid lava. The lava flows over a large area and cools. This creates a large, flat surface of igneous rock. Lava plateaus may be huge. The Columbia Plateau covers over 161,000 square kilometers (63,000 square miles). It makes up parts of the states of Washington, Oregon, and Idaho. Thin, fluid lava created the rock that makes up the entire ocean floor. This is from multiple eruptions from vents at the mid-ocean ridge. While not exactly a lava plateau, its interesting to think about so much lava! New land is created in volcanic eruptions. The Hawaiian Islands are shield volcanoes. These volcanoes formed from fluid lava (Figure 8.21). The island grows as lava is added on the coast. New land may also emerge from lava that erupts from beneath the water. This is one way that new land is created. Magma that cools underground forms intrusions (Figure 8.22). Intrusions become land formations if they are exposed at the surface by erosion. Water works its way through porous rocks or soil. Sometimes this water is heated by nearby magma. If the water makes its way to the surface, it forms a hot spring or a geyser. When hot water gently rises to the surface, it creates a hot spring. A hot spring forms where a crack in the Earth allows water to reach the surface after being heated underground. Many hot springs are used by people as natural hot tubs. Some people believe that hot springs can cure illnesses. Hot springs are found all over the world, even in Antarctica! Geysers are also created by water that is heated beneath the Earths surface. The water may become superheated by magma. It becomes trapped in a narrow passageway. The heat and pressure build as more water is added. When the pressure is too much, the superheated water bursts out onto the surface. This is a geyser. There are only a few areas in the world where the conditions are right for the formation of geysers. Only about 1,000 geysers exist worldwide. About half of them are in the United States. The most famous geyser is Old Faithful at Yellowstone National Park (Figure 8.23). It is rare for a geyser to erupt so regularly, which is why Old Faithful is famous.
Output: hot water that seeps out of a crack at the surface
Shprintzen-Goldberg syndrome is one of a group of disorders characterized by craniosynostosis and marfanoid habitus. Eleven cases were reported previously. We present 4 new patients and review one of the patients of the original report of Shprintzen and Goldberg [1982: J Craniofac Genet Dev Biol 2:65-74], 15 years later. The clinical and radiologic findings on our patients are compared with those of the previously reported patients and also with those of Furlong et al. [1987: Am J Med Genet 26:599-604] and Lacombe and Battin [1993: Clin Dysmorphol 2: 220-224], who share many of the characteristics of Shprintzen-Goldberg syndrome. Some of the clinical data are helpful in determining if the patients of Furlong et al. [1987: Am J Med Genet 26:599-604] and Lacombe and Battin [1993: Clin Dysmorphol 2: 220-224] have a separate syndrome or represent a variant of Shprintzen-Goldberg syndrome. However, radiologic investigations appear to be more specific, since an abnormality of the first and second cervical vertebrae, hydrocephalus, dilatation of the lateral ventricles, and a Chiari-I malformation of the brain were found only in the patients with Shprintzen-Goldberg syndrome. The apparently diagnostic findings of the 15 patients with this syndrome may be helpful in differentiating between Shprintzen-Goldberg syndrome and other syndromes with craniosynostosis and marfanoid habitus.
Output: Which disease is included as an additional feature in the Goldberg-Shprintzen syndrome?
Coming off their divisional road win over the Dolphins, the Jets flew to Ralph Wilson Stadium for a Week 4 AFC East duel with the throwback-clad Buffalo Bills. New York scored in the first quarter as running back LaDainian Tomlinson got a 1-yard touchdown run. The Jets added onto their lead in the second quarter with a 19-yard field goal from kicker Nick Folk, followed by quarterback Mark Sanchez completing a 41-yard touchdown pass to wide receiver Braylon Edwards. The Bills closed out the half with quarterback Ryan Fitzpatrick finding tight end David Martin on a 4-yard touchdown pass. New York pulled away in the third quarter as tight end Dustin Keller caught a 3-yard touchdown pass from wide receiver/quarterback Brad Smith, followed by his 2-yard touchdown reception thrown by Sanchez. Afterwards, Tomlinson's 26-yard touchdown run effectively secured the victory. Buffalo closed out the game in the fourth quarter as Fitzpatrick threw a touchdown pass to wide receiver Steve Johnson.
Output: Which player scored multiple touchdowns?
Double homeobox 4 (DUX4) is a candidate disease gene for facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophies characterized by progressive skeletal muscle degeneration. Despite great strides in understanding precise genetics of FSHD, the molecular pathophysiology of the disease remains unclear. One of the major limitations has been the availability of appropriate molecular tools to study DUX4 protein. In the present study, we report the development of five new monoclonal antibodies targeted against the N- and C-termini of human DUX4, and characterize their reactivity using Western blot and immunofluorescence staining. Additionally, we show that expression of the canonical full coding DUX4 induces cell death in human primary muscle cells, whereas the expression of a shorter splice form of DUX4 results in no such toxicity. Immunostaining with these new antibodies reveals a differential effect of two DUX4 isoforms on human muscle cells. These antibodies will provide an excellent tool for investigating the role of DUX4 in FSHD pathogenesis.
Output: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
When you think of life in the ocean, do you think of fish? Actually, fish are not the most common life forms in the ocean. Plankton are the most common. Plankton make up one of three major groups of marine life. The other two groups are nekton and benthos. Figure 14.24 shows the three groups. Plankton are living things that float in the water. Most plankton are too small to see with the unaided eye. Some examples are shown in Figure 14.25. Plankton are unable to move on their own. Ocean motions carry them along. There are two main types of plankton: 1. Phytoplankton are plant-like plankton. They make food by photosynthesis. They live in the photic zone. Most are algae. 2. Zooplankton are animal-like plankton. They feed on phytoplankton. They include tiny animals and fish larvae. Nekton are living things that swim through the water. They may live at any depth, in the photic or aphotic zone. Most nekton are fish, although some are mammals. Fish have fins and streamlined bodies to help them swim. Fish also have gills to take oxygen from the water. Figure 14.26 shows examples of nekton. Benthos are living things on the ocean floor. Many benthic organisms attach themselves to rocks and stay in one place. This protects them from crashing waves and other water movements. Some benthic organisms burrow into sediments for food or protection. Benthic animals may crawl over the ocean floor. Examples of benthos include clams and worms. Figure 14.27 shows two other examples. Some benthos live near vents on the deep ocean floor. Tubeworms are an example (see Figure 14.28). Scalding hot water pours out of the vents. The hot water contains chemicals that some specialized bacteria can use to make food. Tubeworms let the bacteria live inside them. The bacteria get protection and the tubeworms get some of the food. Figure 14.29 shows a marine food chain. Phytoplankton form the base of the food chain. Phytoplankton are the most important primary producers in the ocean. They use sunlight and nutrients to make food by photosynthesis. Small zooplankton consume phytoplankton. Larger organisms eat the small zooplankton. Larger predators eat these consumers. In an unusual relationship, some enormous whales depend on plankton for their food. They filter tremendous amounts of these tiny creatures out of the water. The bacteria that make food from chemicals are also primary producers. These organisms do not do photosynthesis since there is no light at the vents. They do something called chemosynthesis. They break down chemicals to make food. When marine organisms die, decomposers break them down. This returns their nutrients to the water. The nutrients can be used again to make food. Decomposers in the oceans include bacteria and worms. Many live on the ocean floor. Do you know why?
Output: marine organisms that swim
To develop a clinical prediction rule to identify patients who can be safely discharged one hour after the administration of naloxone for presumed opioid overdose. Patients who received naloxone for known or presumed opioid overdose were formally evaluated one hour later for multiple potential predictor variables. Patients were classified into two groups: those with adverse events within 24 hours and those without. Using classification and regression tree methodology, a decision rule was developed to predict safe discharge. Clinical findings from 573 patients allowed us to develop a clinical prediction rule with a sensitivity of 99% (95% CI = 96% to 100%) and a specificity of 40% (95% CI = 36% to 45%). Patients with presumed opioid overdose can be safely discharged one hour after naloxone administration if they: 1) can mobilize as usual; 2) have oxygen saturation on room air of >92%; 3) have a respiratory rate >10 breaths/min and <20 breaths/min; 4) have a temperature of >35.0 degrees C and <37.5 degrees C; 5) have a heart rate >50 beats/min and <100 beats/min; and 6) have a Glasgow Coma Scale score of 15. This prediction rule for safe early discharge of patients with presumed opioid overdose performs well in this derivation set but requires validation followed by confirmation of safe implementation.
Output: Which medication should be administered when managing patients with suspected acute opioid overdose?
Teleborg Castle (Teleborgs slott) is beautifully situated near Lake Trummen, 4--5 km south of the city centre of Vaxjo, Sweden.
Output: What body of water was Teleborg Castle next to?
Stress is the force applied to an object. In geology, stress is the force per unit area that is placed on a rock. Four types of stresses act on materials. A deeply buried rock is pushed down by the weight of all the material above it. Since the rock cannot move, it cannot deform. This is called confining stress. Compression squeezes rocks together, causing rocks to fold or fracture (break) (Figure 1.1). Compression is the most common stress at convergent plate boundaries. Stress caused these rocks to fracture. Rocks that are pulled apart are under tension. Rocks under tension lengthen or break apart. Tension is the major type of stress at divergent plate boundaries. When forces are parallel but moving in opposite directions, the stress is called shear (Figure 1.2). Shear stress is the most common stress at transform plate boundaries. Shearing in rocks. The white quartz vein has been elongated by shear. When stress causes a material to change shape, it has undergone strain or deformation. Deformed rocks are common in geologically active areas. A rocks response to stress depends on the rock type, the surrounding temperature, the pressure conditions the rock is under, the length of time the rock is under stress, and the type of stress. Rocks have three possible responses to increasing stress (illustrated in Figure 1.3): elastic deformation: the rock returns to its original shape when the stress is removed. plastic deformation: the rock does not return to its original shape when the stress is removed. fracture: the rock breaks. Under what conditions do you think a rock is more likely to fracture? Is it more likely to break deep within Earths crust or at the surface? What if the stress applied is sharp rather than gradual? At the Earths surface, rocks usually break quite quickly, but deeper in the crust, where temperatures and pressures are higher, rocks are more likely to deform plastically. Sudden stress, such as a hit with a hammer, is more likely to make a rock break. Stress applied over time often leads to plastic deformation. Click image to the left or use the URL below. URL:
Output: force per unit area that is placed on an object.
The Garden of Aunt Isabel (Spanish:El jardin de la tia Isabel) is a 1971 Mexican historical drama film directed by Felipe Cazals and starring Jorge Martinez de Hoyos, Claudio Brook and Ofelia Guilmain.
Output: What is the year that The Garden of Aunt Isabel was released?
There were 22,000 households of which 37.1% had children under the age of 18 living with them, 48.3% were Marriage living together, 12.7% had a female householder with no husband present, 5.1% had a male householder with no wife present, and 33.9% were non-families. 26.7% of all households were made up of individuals and 7.5% had someone living alone who was 65 years of age or older. The average household size was 2.70 and the average family size was 3.24.
Output: Which group for households is larger: Marriage living together or non-families?
The TMEM18 protein's amino acid sequence is well conserved, which suggests that it has retained its function since the divergence of human and plants.
Output: In what living being can TMEM18 be found?
The Battle of Coutras, fought on 20 October 1587, was a major engagement in the French Religious Wars between a Huguenot (Protestant) army under Henry of Navarre (the future Henry IV of France) and a royalist army led by Anne, Duke of Joyeuse.
Output: On what date did Battle of Coutras end?
Abi Curtis received a PhD in Creative and Critical Writing from the University of Sussex, and went on to teach there until 2010.
Output: Where did Abi Curtis study or work?
Jonas Valanciunas (Lithuanian pronunciation: (jons vntuns); born 6 May 1992) is a Lithuanian professional basketball player for the Toronto Raptors of the National Basketball Association (NBA).
Output: What team is Jonas Valančiūnas on?
Sergey Kalyakin (Belarusian: ; b. June 16, 1952 in Minsk) is a politician, leader of the Belarusian Left Party ''A Just World'' (till 2009 - the Party of Communists of Belarus).
Output: What political party is Sergey Kalyakin part of?
''The Lighthouse's Tale'' is a song by progressive bluegrass band Nickel Creek, taken from their debut album, Nickel Creek, released in 2001.
Output: Who is the performer of The Lighthouse's Tale?
Heavily in debt, Clinton lobbied the Duke of Newcastle for profitable employment as an American governor: he was appointed Governor of the Province of New York in July 1741 and arrived in New York in September 1743 to take up his position. Promoted to rear-admiral on 10 December 1743 and vice-admiral on 23 June 1744, he sought to protect New York's Northern border from attack by the French: however liberal members of the New York assembly resisted his proposals as they wanted to maintain trade links with the French and with the Native Americans who were under French influence. James De Lancey, who had initially been his main adviser, turned against him and sought to block the governor's salary. Clinton therefore invited Sir William Johnson to take over responsibility for Native American affairs in 1746 and appointed Cadwallader Colden to be his advisor. Clinton was promoted to full admiral on 15 July 1747. Working with the Mohawk chief Hendrick Theyanoguin, Johnson was able to recruit Mohawk warriors to fight on the side of the British in 1747 during King George's War. After continuing disputes with the assembly over military expenditure and payment of the governor's salary, Clinton resigned as governor in October 1753.
Output: What happened second: Clinton was appointed Governor or promoted to rear-admiral?
Jean-Francois Domergue (born 23 June 1957) is a former French footballer who played defender.
Output: In what capacity did Jean-François Domergue play football?
Conus velaensis is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies.
Output: Is Conus velaensis a genus or species?
Denosumab is a human monoclonal antibody which specifically blocks receptor activator of nuclear factor B ligand and is a very potent antiresorptive drug. Its efficacy in reducing the risk of vertebral, hip and nonskeletal fracture has been proven in a large prospective, randomized multicenter study of 7808 postmenopausal women with osteoporosis [Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) trial]. Denosumab causes somewhat greater increases in bone mineral density (BMD) than the class of bisphosphonate antiresorptives. Denosumab also causes an increase in bone mass and bone strength in the spine, ultradistal and diaphysis of the radius, proximal tibia and the hip. Recently long-term treatment with denosumab has been shown to cause a continued almost linear increase in total hip and femoral neck BMD beyond 3 years up to 8 years. In this respect, denosumab seems to differ from the bisphosphonate group in which the rate of improvement of BMD diminishes and for some drugs becomes negative after 3-4 years when the process of secondary mineralization flattens out. This unique property of an antiresorptive drug points towards mechanisms of action which differ from the bisphosphonate group. Both types of antiresorptives decrease cortical porosity but contrary to bisphosphonates the reduction in cortical porosity continues with denosumab which, in addition, also seems to cause a slight continuous modeling-based formation of new bone despite suppression of bone remodeling. The net effect is an increase in cortical thickening and bone mass, and increased strength of cortical bone. This may contribute substantially to the significant further reduction of the nonvertebral fracture risk which was found in the long-term denosumab arm of the FREEDOM extension trial during years 4-7.
Output: Which is the target of the drug Denosumab?
The subventricular zone (SVZ) is an embryonic remnant that persists and remains mitotically active throughout adulthood. The rodent SVZ harbors neuronal precursors, principally in its anterior part, and generates neuroblasts that migrate tangentially into the olfactory bulb, thus forming the so-called rostral migratory stream. This study aimed at characterizing the SVZ in the human brain. Antibodies raised against the widely used SVZ molecular markers nestin, glial fibrillary acidic protein, beta-tubulin-III and polysialylated neural cell adhesion molecule, have allowed us to characterize in detail a zone similar to the rodent SVZ in humans. Virtually all portions of the lateral ventricle, as well as the ventral (hypothalamic) sector of the third ventricle, displayed immunoreactivity for most of the molecular markers. The midline region of the septum (septal recess) and the ventral portion of the SVZ displayed a particularly intense immunostaining for all SVZ markers. These two regions may represent zones of adult neurogenesis that are unique to primates. Furthermore, the anti-apoptotic protein Bcl-2 was found to be actively synthesized and co-expressed with all the other markers throughout the entire SVZ. This study reveals that a well-developed SVZ exists in the adult human brain and suggests that Bcl-2 might play an important role in the functional organization of such a system.
Output: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
Sr-Vagsy is a former municipality in Sogn og Fjordane county in Norway.
Output: In which country would you find Sør-Vågsøy?
The man sitting opposite Robert was the Financial Controller. Everybody called him "the FC" for short. He made all the decisions about money. Robert needed some more. That was why he had to see him. The two men did not get on very well. In fact, they had always disliked each other. "Your request is out of the question," the FC said. Robert had difficulty in controlling himself, but he managed somehow. He explained that he wanted the money in order to make more programmes. "And why do you want to do that?" the FC asked sharply. Again, Robert almost lost his temper. "Because more and more people are listening to my department's programmes. There's great demand for them," he answered. The FC did not seem to believe him. But Robert had a report on the numbers of listeners to all EBC programmes. The FC became less confident. Robert threw the report down on the table and told him to read it. The FC looked at it in silence. The figures proved that he had been wrong, but he did not want to admit it. "Well," he finally said, "I may have made a small mistake." Robert noticed the word "may." He got up to leave. But he had the feeling that he would get the money after all.
Output: Who do you think won the argument in the end?
Energy from the Sun comes from the lightest element, hydrogen, fusing together to create the second lightest element, helium. Nuclear fusion on the Sun releases tremendous amounts of solar energy. The energy travels to the Earth, mostly as visible light. The light carries the energy through the empty space between the Sun and the Earth as radiation. Solar energy has been used for power on a small scale for hundreds of years, and plants have used it for billions of years. Unlike energy from fossil fuels, which almost always come from a central power plant or refinery, solar power can be harnessed locally (Figure 1.1). A set of solar panels on a homes rooftop can be used to heat water for a swimming pool or can provide electricity to the house. Societys use of solar power on a larger scale is just starting to increase. Scientists and engineers have very active, ongoing research into new ways to harness energy from the Sun more efficiently. Because of the tremendous amount of incoming sunlight, solar power is being developed in the United States in southeastern California, Nevada, and Arizona. Solar panels supply power to the Interna- tional Space Station. Solar power plants turn sunlight into electricity using a large group of mirrors to focus sunlight on one place, called a receiver (Figure 1.2). A liquid, such as oil or water, flows through this receiver and is heated to a high temperature by the focused sunlight. The heated liquid transfers its heat to a nearby object that is at a lower temperature through a process called conduction. The energy conducted by the heated liquid is used to make electricity. This solar power plant uses mirrors to focus sunlight on the tower in the center. The sunlight heats a liquid inside the tower to a very high temperature, producing energy to make electricity. Solar energy has many benefits. It is extremely abundant, widespread, and will never run out. But there are problems with the widespread use of solar power. Sunlight must be present. Solar power is not useful in locations that are often cloudy or dark. However, storage technology is being developed. The technology needed for solar power is still expensive. An increase in interested customers will provide incentive for companies to research and develop new technologies and to figure out how to mass-produce existing technologies (Figure 1.3). Solar panels require a lot of space. Fortunately, solar panels can be placed on any rooftop to supply at least some of the power required for a home or business. This experimental car is one example of the many uses that engineers have found for solar energy. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:
Output: the source of solar power is nuclear
The Pronto Mine is an historical uranium mine located approximately 20 km south of Elliot Lake, Ontario near Spragge.
Output: What is the product made by Pronto Mine?
Different rock types weather at different rates. Certain types of rock are very resistant to weathering. Igneous rocks, especially intrusive igneous rocks such as granite, weather slowly because it is hard for water to penetrate them. Other types of rock, such as limestone, are easily weathered because they dissolve in weak acids. Rocks that resist weathering remain at the surface and form ridges or hills. Shiprock in New Mexico is the throat of a volcano thats left after the rest of the volcano eroded away. The rock thats left behind is magma that cooled relatively slowly and is harder than the rock that had surrounded it. Different minerals also weather at different rates. Some minerals in a rock might completely dissolve in water, but the more resistant minerals remain. In this case, the rocks surface becomes pitted and rough. When a less resistant mineral dissolves, more resistant mineral grains are released from the rock. A beautiful example of this effect is the "Stone Forest" in China, see the video below: The Shiprock formation in northwest New Mexico is the central plug of resistant lava from which the surrounding rock weath- ered and eroded away. Click image to the left or use the URL below. URL: A regions climate strongly influences weathering. Climate is determined by the temperature of a region plus the amount of precipitation it receives. Climate is weather averaged over a long period of time. Chemical weathering increases as: Temperature increases: Chemical reactions proceed more rapidly at higher temperatures. For each 10o C increase in average temperature, the rate of chemical reactions doubles. Precipitation increases: More water allows more chemical reactions. Since water participates in both mechan- ical and chemical weathering, more water strongly increases weathering. So how do different climates influence weathering? A cold, dry climate will produce the lowest rate of weathering. A warm, wet climate will produce the highest rate of weathering. The warmer a climate is, the more types of vegetation it will have and the greater the rate of biological weathering (Figure 1.2). This happens because plants and bacteria grow and multiply faster in warmer temperatures. Some resources are concentrated by weathering processes. In tropical climates, intense chemical weathering carries away all soluble minerals, leaving behind just the least soluble components. The aluminum oxide, bauxite, forms this way and is our main source of aluminum ore.
Output: climate is determined by
Count Lasher entered some of the music competitions held regularly at Jamaica's Ward's Theatre.
Output: Which country's citizen was Count Lasher?
Mutations in the K-ras oncogene and in the p53 tumor suppressor gene are commonly identified in sporadic cases of pancreatic adenocarcinoma. Although these genes might serve as useful markers for early diagnosis of pancreatic carcinoma in patients at risk for the development of this disease, familial pancreatic carcinomas have not been studied for these mutations. We recently had the opportunity to examine a pancreas prophylactically removed from a patient with a strong family history of pancreatic carcinoma. This gave us the unique opportunity to study the early events in the development of familial adenocarcinoma of the pancreas. Histopathological examination of the pancreas revealed multifocal papillary and nonpapillary mucinous duct hyperplasia. Seven of these foci were microdissected and analyzed for K-ras and p53 mutations. The K-ras mutations were detected by combined mutant-enriched polymerase chain reaction-restriction fragment length polymorphism analysis and characterized further by allele-specific oligonucleotide hybridization. Five of the seven duct lesions harbored activating point mutations in codon 12 of K-ras; a G to A transition was found in four and a G to C transversion in one. In contrast, these lesions did not harbor detectable p53 mutations as determined by denaturing gradient gel electrophoresis of exons 5 to 8, nor was there overexpression of the p53 protein as determined by immunohistochemistry. These findings suggest that mutations in K-ras represent an early event in the pathogenesis of pancreatic carcinoma. In addition, monitoring of patients with a strong family history of pancreatic carcinoma for K-ras mutations may identify patients at risk for the development of invasive carcinoma.
Output: Which is the molecular mechanism underlying K-ras alterations in carcinomas?
In the mean time, Maha Nawrahta opened the southern front on 23 October 1765 in three directions. He had 20,000 to 30,000 under his command. A small army invaded by the Three Pagodas Pass towards Suphanburi. Another small army invaded down the Tenasserim coast towards Mergui and Tenasserim town. However, the main thrust of his attack was at Kanchanaburi. His 20,000-strong main southern army invaded via the Myitta Pass. Kanchanaburi fell with little resistance. The main reason for the quick fall of Kanchanaburi could be that the Burmese were more battle-hardened. But it could also be that the Siamese command miscalculated where the Burmese main attack would come from, and had not sufficiently reinforced the fort to withstand a major attack. Judging by the Siamese chronicles' reporting of the main attack route, the Siamese command appeared to have believed that the main Burmese attack would come from the Gulf of Siam coastline, instead of the most obvious and shortest route via Kanchanaburi. The Siamese sources say that Maha Nawrahta's main invasion route came from southern Tenasserim, crossing the Tenasserim range at Chumphon and Phetburi. The path is totally different from the Kanchanaburi route reported by the Burmese chronicles. Historian Kyaw Thet specifically adds that the main attack route was via the Myitta Pass.
Output: How many Maha Nawrahta opened the southern front?
The DRG Class 99.19 engines were metre gauge, ten-coupled, superheated, steam locomotives that were employed in the southwestern German state of Wurttemberg from 1927.
Output: What was the year that DRG Class 99.19 entered service?
The film is based on the Auguste Le Breton novel, Du rififi chez les femmes, published in 1957 and reprinted in 2010.
Output: The person that directed Du rififi chez les femmes was what?
Food Force is an educational game published by the United Nations World Food Programme (WFP) in 2005.
Output: What business published Food Force?
One day, a brave jackal came to the river to drink some water. He saw a lion looking weak and tired, and asked, "What is the matter, King of the Jungle?" The lion told the jackal his story. The jackal felt sorry for the lion. He pulled and pulled at the lion's tail until the lion became free. The lion was very happy and said, "Thank you so much for helping me. I thought I would die! You are my friend for life! I would like you to come and live with me. From now on, I will hunt and share my food with you." The jackal moved in with the lion's family and had a wonderful time. Soon, the lion had children of his own and so did the jackal. The lioness was not happy about the friendship. She complained to her children. Her children complained to the jackal's children; the jackal's children complained to their mother and their mother complained to the jackal. The jackal was upset and told the lion, "You told me to live with you. If you don't like it any more, you should have said so yourself." The lion was shocked and said, "This is not true. I've never complained about you. I still want you to continue staying with me." The jackal said, "We understand each other. But our families don't. Perhaps it is better for us to live apart, but continue meeting each other when we are free. We can even hunt together!" The two families parted, but the lion and the jackal met often and remained friends for the rest of their lives. From the above paragraphs, we can conclude that in order to keep our good friendship, we have to give something up or give in in some particular cases. However, we can never give up or destroy our families. What do you think of it?
Output: How was the lion when the jackal first met him?
Susana Machado Bernard House and Barn is an elaborate 10,000-square-foot (930 m2) Art Nouveau Gothic Revival style mansion and carriage house located in the Pico Union section of Los Angeles, California.
Output: Of what style is Susana Machado Bernard House and Barn?
Paul MacDermid (born April 14, 1963 in Chesley, Ontario) is a retired professional ice hockey right winger who played 690 games in the National Hockey League (NHL) for the Hartford Whalers, Winnipeg Jets, Washington Capitals, and Quebec Nordiques.
Output: On what team is Paul MacDermid?
Gabriel Bourque (born September 23, 1990) is a Canadian professional ice hockey player who is currently playing for the Nashville Predators in the National Hockey League (NHL).
Output: What team is Gabriel Bourque associated with?
Sumu-Epuh apparently was killed in c. 1780 BC during his fight with Shamshi-Adad, his successor was Yarim-Lim I, his son by his queen Sumunna-Abi.
Output: What was Sumu-Epuh's child's name?
Bilal Rifaat (born 27 September 1957) is an Egyptian fencer.
Output: When was Bilal Rifaat born?
Hello, Listeners. Welcome to Henton Hospital Radio. Before our music programme at four, I'm going to repeat some of our hospital rules. The hospital can sleep 800 patients. There're 8 beds in each ward . The visiting hours are in the afternoon from 2:30 to 3:30 and in the evening from 7:00 to 8:00. But remember only two people can see you at the same time. Sorry about that, but you can see what would happen if we didn't have these rules. The other rules are about our hours. We start quite early---you might not be used to that. We wake you at 6 o'clock, and breakfast is at 8 o'clock, lunch is at noon. There's tea at 3:30 and supper is at 6 o'clock. You can see the non-smoking sign---we don't allow smoking in the wards. I'm sure you understand why. However, if you do need to smoke, there are some smoking rooms where it is allowed. You will find the radio switch on the wall near your bed, with your own headphones, if you want to listen. It's our own hospital radio wishing you a quick recovery.
Output: Who do you think the listeners might be?
GNU LibreDWG is a software library programmed in C to manage DWG computer files, native proprietary format of computer-aided design software AutoCAD.
Output: What is the programming language for LibreDWG?
Imatinib mesylate is a tyrosine kinase inhibitor with high affinity for the BCR-ABL fusion protein expressed by the hematopoietic cells in chronic myelogenous leukemia (CML). Some patients with chronic-phase or accelerated-phase CML either relapse after an initial response or are refractory to imatinib, prompting us to evaluate the efficacy of dose increase in such patients. Twelve chronic-phase patients initially receiving 400 mg/day and 4 patients with accelerated phase initially receiving either 400 mg/day (two patients) or 600 mg/day (two patients) had their dose increased (14 to 800 mg/day and 2 to 600 mg/day) because of progressive disease (usually clonal evolution) or inadequate cytogenetic response after at least 1 year of therapy. Six patients had major cytogenetic responses after dose increase (3 complete and 3 partial). Two others had minor cytogenetic responses. Two patients with clonal evolution transiently lost the additional clonal aberrations. Almost all of the responses occurred within 6 months, and were typically 3-6 months in duration. However, 3 patients have continuing major cytogenetic responses of >18 months duration. Dose increase was well tolerated, with thrombocytopenia, mild leukopenia, and exacerbation of prior edema being the most common adverse events. Although increasing the dose of imatinib can benefit a subgroup of patients with CML with either an inadequate cytogenetic response or disease progression, our results suggest the majority will not have a sustained meaningful response, and that other options, such as allogeneic stem cell transplant or investigational therapies, also need to be considered at the time of dose increase.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Marigold Lexton (Ali Larter), a self-centered and temperamental young American actress, arrives in India expecting to be treated like a star, despite the fact that she has been making nothing but B movie sequels for some time. She is stranded in Goa after the film she was to star in is canceled, and a sympathetic crew member offers her a ride, which brings her to the set of another movie, a Bollywood musical. She actually tells her boyfriend Barry that she was hoping she wouldn't have to marry him if this trip was successful, and soon finds herself the center of attraction on the set, where she quickly lands a minor role and a date with the spoiled young lead actor. But after she rebuffs his crude proposal that night she winds up talking with Prem (Salman Khan), the film's choreographer. He knows she lied about being able to dance, and takes her in hand, while showing her the nearby towns and countryside in their spare time. As they grow closer Prem talks to her about the importance of family, and she not only learns that he is estranged from his father, but that he is also a prince. He had not seen his family in three years, but the day before he received a call from his sister, asking him to come home for her wedding. He asks Marigold to go home with him to Jodhpur, Rajasthan, for the wedding, since shooting on the movie had been shut down for a week. She is entranced by the generosity and opulence of his family leading up to the wedding, but afterwards is shocked to discover that he has been betrothed to another since childhood. He has fallen totally in love with Marigold, but has neglected to mention the long arranged marriage, and his father has not encouraged him to follow his heart. She feels betrayed and storms out, followed by Prem's fiance, who offers to buy her a drink. She confesses to Marigold that although she loves Prem she doesn't believe he has ever really loved her. Meanwhile, Prem, a teetotaler, heads to a bar to drown his sorrows, where he finds a drunken American who commiserates with his romantic problems. He explains he has come looking for his estranged girlfiend, called Marigold, and Prem invites him to stay the night at his parents' house. Barry accepts and then passes out. In the morning, Marigold decides to return with Barry to the United States, since Prem, the only son of Jaipur's Ruler, feels duty bound to marry the woman his father has chosen. The ceremony takes place that day, and as he follows his bride, whose face is totally hidden behind a long veil, seven times around the Holy fire, Prem believes he is marrying the woman he has been engaged to since childhood. With the marriage complete, Prem lifts his wife's veil, and he and most of the guests are astonished to find Marigold standing before himand it appears that Barry has married Prem's former fiance as well. The movie's director and their friends from the crew appear in the crowd, cheering, then Prem sings and dances with Marigold and a full chorus, just like a happy ending in a Bollywood musical.
Output: Where does the young American travel to?
The Web site for the Anxiety Disorders Association of America (ADAA) receives more than 5 million visits per month and thus represents a unique medium for the study of anxiety disorders. ADAA Web site users from October 2002 to January 2003 were invited to complete a survey oriented toward trauma history and psychiatric sequelae. A diagnostic approximation of posttraumatic stress disorder (PTSD) was based on responses to the Trauma Questionnaire, the Davidson Trauma Scale, and questions about impairment. The Connor-Davidson Resilience Scale was also used. Variables were tested for their association with PTSD. Among 1558 participants, 87% had a history of trauma, and 38% had current PTSD. The population was comprised predominantly of white middle-class women, half of whom were married. More than 90% were first-time users of the site. Factors associated with PTSD included death of, or harm to, a loved one; personal history of incest, rape, or physical abuse; lower age; lower income; unemployment; missed work; increased medical care; dissatisfaction with psychotropic medication; depressive symptoms; and lower resilience. In this selective convenience sample, there were high rates of traumatization and PTSD. The demographics of this group are similar to those seen in previously studied populations that had contacted the ADAA. Furthermore, the factors associated with PTSD were like those in many community surveys. The ADAA Web site has the opportunity to benefit large numbers of highly distressed individuals.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
You love Jay Chou's songs and you can sing some quite well. So you make a video of your performance and post it online for your friends to see. But what if this led to something beyond your wildest imagination--a career in music? Canadian teenager Justin Bieber, 16, has just had the magical experience: He posted homemade videos of his versions of songs by American singer Chris Brown online for his relatives. He received a phone call from Brown, telling him how much he liked his performance. His singing eventually earned him a fan base and a record contract. After releasing a popular record in November 2009, his album My world 2.0 came out last Tuesday. Bieber sings ballads and songs about puppy love. But is he just another gooey teen idol? David Malitz, a columnist with the Washington Post, doesn't think so. "If we truly want the best forAmerican children, let us pause and give thanks for Justin Bieber," he writes. "After years of humdrum bubblegum from Miley Cyrus and the Jonas Brothers, the 16yearold has thrown a candycoated wrench into Disney's heartthrob assembly line by giving young fans something worth screaming their lungs out for lovable pop songs." From a boy who grew up below the poverty line with his divorced mom to a star who caused nearriots in shopping malls, even Bieber himself can't believe his overnight fame, although his kind of success is becoming more and more common in the Internet era. Interested in hockey, the national sport of Canada, the boy once put up pictures of players on the walls of his bedroom. He dreamed of being a hockey star and used to practice signing his autograph. He doesn't need practice now. He signs autographs, if the girls can get close enough, as a music star.
Output: What's Justin Bieber's hobby?
The Prisoner of Second Avenue is an American black comedy play by Neil Simon, later made into a film released in 1975.
Output: Who was the director of The Prisoner of Second Avenue?
The Battle of Tarcal or Battle of Tokaj (Hungarian: Tarcali csata) was a battle fought on 27 September 1527 near Tokaj between the Habsburg-German-Hungarian forces of Archduke Ferdinand of Austria and an opposing Hungarian army under the command of John Zapolya.
Output: What date is associated with Battle of Tarcal?
Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy.
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
In 1545, Polin was on his way to fight against the English in the area of Boulogne. While in Marseilles in 1545, Polin was involved as a leader in the massacre of the Protestant Waldensians . Outside the Piedmont the Waldenses joined the local Protestant churches in Bohemia, France and Germany. After they came out of clandestinity and reports were made of sedition on their part, the French king, Francis I issued on 1 January 1545 the "Arret de Merindol", and armed a crusade against the Waldensians of Provence. The leaders in the 1545 massacres were Jean Maynier d'Oppede, First President of the parlement of Provence, and Antoine Escalin des Aimars who was returning from the Italian Wars with 2,000 veterans, the Bandes de Piemont. Deaths ranged from hundreds to thousands, depending on the estimates, and several villages were devastated.
Output: Where was Polin going before the massacre?
Recently mutations in the gene ZFHX1B (SIP1) were shown in patients with "syndromic Hirschsprung disease" with mental retardation (MR) and multiple congenital anomalies (MCA), but it was unclear if Hirschsprung disease is an obligate symptom of these mutations and if the distinct facial phenotype delineated by Mowat et al. [1998: J Med Genet 35: 617-623] is specific for ZFHX1B mutations. In order to address these open questions we analyzed the ZFHX1B gene in five patients, three of whom had "syndromic Hirschsprung disease" two with and one without the facial phenotype described by Mowat et al. [1998], and two of whom had the distinct facial gestalt without Hirschsprung disease. Analyses of microsatellite markers and newly identified SNPs, and/or FISH with BACs from the ZFHX1B region excluded large deletions in all five patients. Direct sequencing demonstrated truncating ZFHX1B mutations in all four patients with the characteristic facial phenotype, but not in the patient with syndromic Hirschsprung disease without the distinct facial appearance. We demonstrate that there is a specific clinical entity with a recognizable facial gestalt, mental retardation and variable MCAs which we propose be called the "Mowat-Wilson syndrome."
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Night Girl (Lydda Jath) is a fictional character in the 30th century of the DC Universe.
Output: With which fictional universe is the character Night Girl associated?