niryuu/sni-each-converted huggingface dataset:
Water is simply two atoms of hydrogen and one atom of oxygen bonded together (Figure 1.1). The hydrogen ions are on one side of the oxygen ion, making water a polar molecule. This means that one side, the side with the hydrogen ions, has a slightly positive electrical charge. The other side, the side without the hydrogen ions, has a slightly negative charge. Despite its simplicity, water has remarkable properties. Water expands when it freezes, has high surface tension (because of the polar nature of the molecules, they tend to stick together), and others. Without water, life might not be able to exist on Earth and it certainly would not have the tremendous complexity and diversity that we see. Water is the only substance on Earth that is present in all three states of matter - as a solid, liquid or gas. (And Earth is the only planet where water is abundantly present in all three states.) Because of the ranges in temperature in specific locations around the planet, all three phases may be present in a single location or in a region. The three phases are solid (ice or snow), liquid (water), and gas (water vapor). See ice, water, and clouds (Figure 1.2). (a) Ice floating in the sea. Can you find all three phases of water in this image? (b) Liquid water. (c) Water vapor is invisible, but clouds that form when water vapor condenses are not. Click image to the left or use the URL below. URL:
Output: hydrogen atoms have this kind of charge.
Bahram Vallis is an ancient river valley in the Lunae Palus quadrangle of Mars at 20.7 north latitude and 57.5 west longitude.
Output: The astronomical body that Bahram Vallis was located on was what?
Wars and Rumors of Wars is the third full-length album from the band The Chariot.
Output: Who made Wars and Rumors of Wars?
Sajal Barui (Bengali: ) is a convicted criminal who is serving a life sentence in prison for the murder of his father, stepmother, and stepbrother.
Output: Which crime led to the conviction of Sajal Barui?
Abnormal accumulation of Abeta and tau in senile plaques (SP) and neurofibrillary tangles (NFTs) is a key event in Alzheimer's disease (AD). Here, we show that T668-phosphorylated cytoplasmic domain of APP (pT668-ACD) accumulates Abeta and tau in AD and its transgenic models. Anti-pT668 immunostaining of AD brain sections with hydrated autoclave enhancement identified SP neurites and NFTs in which pT668-ACD colocalizes with tau. We produced and examined transgenic (Tg) mice that overexpress human APP695, harboring the double Swedish/London mutation, and develop age-dependently Abeta plaques in the brain. All Abeta plaques contain co-accumulations of pT668-ACD, but co-accumulation of tau appears in only a fraction of Abeta plaques in older animals. We also examined the established tau Tg mice that overexpress the smallest human brain tau isoform and develop neuronal accumulations of tau in older animals. Examination of the old tau Tg mice showed that neuronal cells affected by tau accumulation induce co-accumulation of pT668-ACD. We speculate that in AD brains, extracellular Abeta deposition is accompanied by intracellular accumulation of pT668-ACD, followed by tau accumulation in the SP with dystrophic neurites and that neuronal cells affected by tau accumulation induce co-accumulation of pT668-ACD in NFTs. Thus, pT668-ACD is likely to mediate pathological interaction between Abeta and tau.
Output: Which disease the London mutation involved in?
Born in Brognard, France, in the department of Doubs near Montbeliard, Pierre Widmer was raised in a Mennonite family.
Output: Where did Pierre Widmer live when he died?
Limited data exist about the molecular types of methicillin-resistant Staphylococcus aureus (MRSA) strains found in children with cystic fibrosis (CF). We sought to characterize MRSA strains from these patients and compare them with MRSA strains from non-CF pediatric patients. All MRSA isolates were collected prospectively at Children's Medical Center in Dallas, TX, and the University of Chicago Comer Children's Hospital in 2004 to 2005. All CF MRSA isolates underwent susceptibility testing, multilocus sequence typing, Panton-Valentine leukocidin gene detection (pvl+), and staphylococcal chromosome cassette mec (SCCmec) typing. A total of 22 of 34 MRSA isolates (64.7%) from patients with CF belonged to clonal complex (CC) 5 and contained SCCmec II, so-called health-care associated MRSA (HA-MRSA) strains. Nine of 34 MRSA strains (26.5%) were CC 8, and contained SCCmec IV, so-called community-associated MRSA (CA-MRSA) strains. The CA-MRSA strains tended to be isolated from newly colonized CF patients. In contrast, CC8 isolates predominated among the non-CF patients (294 of 331 patients; 88.8%). MRSA isolates from children with CF were more likely to be resistant to clindamycin (65% vs 19%, respectively) and ciprofloxacin (62% vs 17%, respectively) compared with strains from non-CF patients (p < 0.001). There was no difference in the rate of pvl+ isolate recovery from children with CF undergoing a surveillance culture (7 of 23 children) compared with those with pulmonary exacerbation (3 of 11 children; p = 1.0). Both CA-MRSA (CC8) isolates and HA-MRSA (CC5) isolates populate the respiratory tracts of children with CF. HA-MRSA isolates predominated, but CA-MRSA strains predominated among CF patients with newly acquired MRSA strains and among the non-CF patients. The presence of CA-MRSA strains in children with CF was not associated with exacerbation or necrotizing pneumonia.
Output: What is MRSA?
SET domain methyltransferases deposit methyl marks on specific histone tail lysine residues and play a major role in epigenetic regulation of gene transcription. We solved the structures of the catalytic domains of GLP, G9a, Suv39H2 and PRDM2, four of the eight known human H3K9 methyltransferases in their apo conformation or in complex with the methyl donating cofactor, and peptide substrates. We analyzed the structural determinants for methylation state specificity, and designed a G9a mutant able to tri-methylate H3K9. We show that the I-SET domain acts as a rigid docking platform, while induced-fit of the Post-SET domain is necessary to achieve a catalytically competent conformation. We also propose a model where long-range electrostatics bring enzyme and histone substrate together, while the presence of an arginine upstream of the target lysine is critical for binding and specificity. This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1.
Output: What is the characteristic domain of histone methyltransferases?
The Giants ended a five-game losing streak to the Cowboys dating to October 28, 2012 at AT&T Stadium, doing so despite only 289 aggregate yards of offense. Two touchdowns were scored by either defense or special teams, first on a Matt Cassel pick-six run back 58 yards by Dominique Rodgers-Cromartie in the third quarter; in the fourth following a game-tying Cassel score to Devin Street the ensuing kickoff was run back 100 yards by Dwayne Harris. The game earned additional notoriety; in response to the presence on the Cowboys roster of Greg Hardy with domestic violence controversy surrounding him the Giants invited actress and outspoken advocate of domestic-violence victims Mariska Hargitay along with her husband Peter Hermann and their son August Miklos Hermann to be honorary captains; Hargitay and Hermann wore Mark Herzlich jerseys while August wore a jersey of Odell Beckham Jr. This was Tom Coughlin's last victory in East Rutherford as coach of the Giants.
Output: Where was the game played?
Kanslikajen (Swedish: ''Chancellery Quay'') is a quay in Gamla stan, the old town of Stockholm, Sweden, leading west along the southern shore of the canal Stallkanalen from Stallbron and Mynttorget to Vasabron.
Output: Which is the body of water by Kanslikajen?
This game is well known for an infamous penalty that occurred during the overtime period. The Jets were lining up for a game winning 56-yard field goal in overtime to try and give them the win. Nick folk kicked the ball, but the kick went wide right and the Patriots appeared to be taking over with a chance to win. However, Chris Jones of New England was called for a controversial unsportsmanlike conduct penalty after pushing his teammate into the offensive line. This penalty would later be named "leaping". The penalty gave the Jets another chance and made the field goal attempt a 51-yard attempt. This time, Folk drilled the kick, and the Jets would go on to stun the Patriots. With the win, the Jets improved to 4-3.
Output: what is this penalty known as?
521 Brixia is a minor planet orbiting the Sun that was discovered by American astronomer Raymond Smith Dugan on January 10, 1904.
Output: The inventor of 521 Brixia was whom?
Gul Pacha Ulfat (Pashto: ) was born in 1909 in Qarghayi District of Laghman Province, Afghanistan.
Output: What city did Gul Pacha Ulfat live when he died?
Defects in DNA mismatch repair have been associated with both hereditary and sporadic forms of cancer. Recently, it has been shown that human cell lines deficient in mismatch repair were also defective in the transcription-coupled repair (TCR) of UV-induced DNA damage. We examined whether TCR of ionizing radiation-induced DNA damage also requires the genes involved in DNA mismatch repair. Cells defective in the hMSH2 gene were deficient in the removal of oxidative damage, including thymine glycols, from the transcribed strand of an active gene. However, an hMLH1 mutant showed normal levels of TCR. By comparison, defects in either hMSH2 or hMLH1 resulted in reduced TCR of UV damage. Introducing chromosomes carrying either hMSH2 or hMLH1 into these cell lines restored their ability to carry out TCR. Deficiencies in either hMSH2 or hMLH1 did not result in decreased overall genomic levels of repair or lead to an increased sensitivity to either UV or ionizing radiation. Our results provide the first evidence for a protein that is absolutely required for the preferential removal of UV-induced DNA damage but not oxidative DNA damage from the transcribed strand of an active human gene.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
Lu Fang is a fictional character in Water Margin, one of the Four Great Classical Novels of Chinese literature.
Output: To which fictional work does Lü Fang belong in?
Chopiatyn (xwpjatn) is a village in the administrative district of Gmina Dohobyczow, within Hrubieszow County, Lublin Voivodeship, in eastern Poland, close to the border with Ukraine.
Output: With which country would you associate Chłopiatyn?
Reza Rezaee (Persian: ; born December 24, 1960) is a Norwegian-Iranian politician representing the left-wing political party Red.
Output: What was the political party of Reza Rezaee?
Henry Shutes (1804 -- September 10, 1889) was a Union Navy sailor in the American Civil War and a recipient of the U.S. military's highest decoration, the Medal of Honor, for his actions at the Battle of Forts Jackson and St. Philip and an 1863 engagement with Fort McAllister, Georgia.
Output: What military branch was Henry Shutes associated with?
Cytoskeletal proteins belonging to the spectrin family have an elongated structure composed of repetitive units. The three-dimensional solution structure of the 16th repeat from chicken brain alpha-spectrin (R16) has been determined by NMR spectroscopy and distance geometry-simulated annealing calculations. We used a total of 1035 distance restraints, which included 719 NOE-based values obtained by applying the ambiguous restraints for iterative assignment (ARIA) method. In addition, we performed a direct refinement against 1H-chemical shifts. The final ensemble of 20 structures shows an average RMSD of 1.52 A from the mean for the backbone atoms, excluding loops and N and C termini. R16 is made up of three antiparallel alpha-helices separated by two loops, and folds into a left-handed coiled-coil. The basic unit of spectrin is an antiparallel heterodimer composed of two homologous chains, beta and alpha. These assemble a tetramer via a mechanism that relies on the completion of a single repeat by association of the partial repeats located at the C terminus of the beta-chain (two helices) and at the N terminus of the alpha-chain (one helix). This tetramer is the assemblage able to cross-link actin filaments. Model building by homology of the "tetramerization" repeat from human erythrocyte spectrin illuminates the possible role of point mutations which cause hemolytic anemias.
Output: Alpha-spectrin and beta-spectrin subunits form parallel or antiparallel heterodimers?
2 Marsham Street is an office building on Marsham Street in the City of Westminster, London, and has been the headquarters of the Home Office, a department of the British Government, since March 2005.
Output: What team uses 2 Marsham Street?
Cloud Foundry is primarily written in Ruby and Go.
Output: What programming language was used to write Cloud Foundry?
Coming off their road win over the Steelers, the Colts went home for a Week 11 AFC South rematch with the Houston Texans. In the first quarter, Indianapolis trailed early as Texans kicker Kris Brown got a 28-yard field goal. The Colts responded with kicker Adam Vinatieri getting a 40-yard field goal. Houston would answer with Brown making a 34-yard field goal. In the second quarter, Indy tied the game as Vinatieri got a 39-yard field goal. The Texans retook the lead as RB Ahman Green got a 1-yard TD run. Indianapolis closed out the half as Vinatieri made a 32-yard field goal. In the third quarter, the Colts took the lead as QB Peyton Manning completed a 23-yard TD pass to RB Joseph Addai. Houston would reply as RB Steve Slaton got a 71-yard TD run, yet Indy regained the lead as Addai got a 7-yard TD run. In the fourth quarter, the Texans tried to come back as Green got a 2-yard field goal, yet Indianapolis pulled away with Vinatieri nailing a 31-yard field goal. On the Texans' final drive, QB Sage Rosenfels was intercepted by safety Melvin Bullitt (who was filling in again for the injured Bob Sanders). Ironically, it was Bullitt who picked off Rosenfels on the Texans' final drive when they played the Colts in Week 5. Manning then took a knee, preserving the Colts' third consecutive victory.
Output: Which player kicked the longest field goal?
This marked the first of four games against potential playoff-bound teams in the Texans, Atlanta Falcons, Buffalo Bills, and Indianapolis Colts. The Browns saw their three-game winning streak end as the Texans' defense and run game dominated the Browns in a 23-7 blowout loss. Texans DE J. J. Watt, who played tight end in high school, scored the 5th offensive TD of his career. The Browns' lone score came in the 2nd quarter. A touchdown from Brian Hoyer to Browns' receiver Andrew Hawkins tied the game at 7 in the second quarter. However, the Texans scored the final 16 points of the contest. Hoyer struggled as he was 20/50 passing for 330 yards, throwing only one touchdown while throwing a 4th quarter interception. It was only the second time this season that the Browns got shut out in the second half of a game, an event that also occurred in their 24-6 loss to the Jaguars. With the loss, the Browns fell out of 1st place in the AFC North and into a tie for 3rd place behind the Bengals and Steelers, who both won that week. Defensive linemen John Hughes and Phil Taylor were lost for the season on IR, and Jordan Cameron missed his 3rd straight game due to a concussion. On November 18, the Browns released RB Ben Tate.
Output: Which player had a 4th quarter interception, Hoyer or Hawkins?
Reflection is one of several ways that light can interact with matter. Light reflects off surfaces such as mirrors that do not transmit or absorb light. When light is reflected from a smooth surface, it may form an image. An image is a copy of an object that is formed by reflected (or refracted) light. Q: Is an image an actual object? If not, what is it? A: No, an image isnt an actual object. It is focused rays of light that make a copy of an object, like a picture projected on a screen. If a surface is extremely smooth, as it is in a mirror, then the image formed by reflection is sharp and clear. This is called regular reflection (also called specular reflection). However, if the surface is even slightly rough or bumpy, an image may not form, or if there is an image, it is blurry or fuzzy. This is called diffuse reflection. Q: Look at the boats and their images in the Figure 1.1. Which one represents regular reflection, and which one represents diffuse reflection? A: Reflection of the boat on the left is regular reflection. The water is smooth and the image is sharp and clear. Reflection of the boat on the right is diffuse reflection. The water has ripples and the image is blurry and wavy. In the Figure 1.2, you can see how both types of reflection occur. Waves of light are represented by arrows called rays. Rays that strike the surface are referred to as incident rays, and rays that reflect off the surface are known as reflected rays. In regular reflection, all the rays are reflected in the same direction. This explains why regular reflection forms a clear image. In diffuse reflection, the rays are reflected in many different directions. This is why diffuse reflection forms, at best, a blurry image. One thing is true of both regular and diffuse reflection. The angle at which the reflected rays leave the surface is equal to the angle at which the incident rays strike the surface. This is known as the law of reflection. The law is illustrated in the Figure 1.3.
Output: rays of light are reflected in many different directions in
Selenoproteins are a family of proteins that share the common feature of containing selenocysteine, the "twenty-first" amino acid. Selenocysteine incorporation occurs during translation of selenoprotein messages by redefinition of UGA codons, which normally specify termination of translation. Studies of the eukaryotic selenocysteine incorporation mechanism suggest that selenocysteine insertion is inefficient compared with termination. Nevertheless, selenoprotein P and several other selenoproteins are known to contain multiple selenocysteines. The production of full-length (FL) protein from these messages would seem to demand highly efficient selenocysteine incorporation due to the compounding effect of termination at each UGA codon. We present data demonstrating that efficient incorporation of multiple selenocysteines can be reconstituted in rabbit reticulocyte lysate translation reactions. Selenocysteine incorporation at the first UGA codon is inefficient but increases by approximately 10-fold at subsequent downstream UGA codons. We found that ribosomes in the "processive" phase of selenocysteine incorporation (i.e., after decoding the first UGA codon as selenocysteine) are fully competent to terminate translation at UAG and UAA codons, that ribosomes become less efficient at selenocysteine incorporation as the distance between UGA codons is increased, and that efficient selenocysteine incorporation is not dependent on cis-acting elements unique to selenoprotein P. Furthermore, we found that the percentage of ribosomes decoding a UGA codon as selenocysteine rather than termination can be increased by 3- to 5-fold by placing the murine leukemia virus UAG read-through element upstream of the first UGA codon or by providing a competing messenger RNA in trans. The mechanisms of selenocysteine incorporation and selenoprotein synthesis are discussed in light of these results.
Output: Which is the human selenoprotein that contains several Se-Cys residues?
The Texans' ninth match was an AFC South rivalry match against the Jaguars at EverBank Field. In the first quarter the Texans trailed early as kicker Josh Scobee hit a 38-yard field goal. They replied after kicker Neil Rackers made a 24-yard field goal. They trailed again in the 2nd quarter with RB Maurice Jones-Drew getting a 3 and a 9-yard TD run. However, the lead didn't last long after RB Arian Foster got a 1-yard TD run, and QB Matt Schaub threw a 9-yard TD pass to WR Andre Johnson. The Jaguars stayed in the lead when QB David Garrard completed a 52-yard TD pass to TE Zach Miller, but the Texans replied again with Schaub finding WR Kevin Walter on an 18-yard TD pass. Suddenly, the Texans' defense broke through with only a few seconds remaining after Garrard made a 50-yard TD pass to WR Mike Thomas. The ball was batted into his hands by Texans Defensive back Glover Quin, who made an attempt to bat the ball to the ground.
Output: Which kicker's first quarter field goal was shorter?
Thomas Christopher Boyd (14 August 1916 -- 15 March 2004) was a British Labour Party politician.
Output: What political party is Thomas Christopher Boyd part of?
U.K ambulance services assess patients with suspected stroke using the Face Arm Speech Test (FAST). The Recognition Of Stroke In the Emergency Room (ROSIER) tool has been shown superior to the FAST in identifying strokes in emergency departments but has not previously been tested in the ambulance setting. We investigated whether ROSIER use by ambulance clinicians can improve stroke recognition. Ambulance clinicians used the ROSIER in place of the FAST to assess patients with suspected stroke. As the ROSIER includes all FAST elements, we calculated a FAST score from the ROSIER to enable comparisons between the two tools. Ambulance clinicians' provisional stroke diagnoses using the ROSIER and calculated FAST were compared with stroke consultants' diagnosis. We used stepwise logistic regression to compare the contribution of individual ROSIER and FAST items and patient demographics to the prediction of consultants' diagnoses. Sixty-four percent of strokes and 78% of nonstrokes identified by ambulance clinicians using the ROSIER were subsequently confirmed by a stroke consultant. There was no difference in the proportion of strokes correctly detected by the ROSIER or FAST with both displaying excellent levels of sensitivity. The ROSIER detected marginally more nonstroke cases than the FAST, but both demonstrated poor specificity. Facial weakness, arm weakness, seizure activity, age, and sex predicted consultants' diagnosis of stroke. The ROSIER was not better than the FAST for prehospital recognition of stroke. A revised version of the FAST incorporating assessment of seizure activity may improve stroke identification and decision making by ambulance clinicians.
Output: ROSIER scale is used for which disorder?
MathJax is a cross-browser JavaScript library that displays mathematical notation in web browsers, using MathML, LaTeX and ASCIIMathML markup.
Output: What programming language was used to write MathJax?
The waves in the picture above are examples of mechanical waves. A mechanical wave is a disturbance in matter that transfers energy through the matter. A mechanical wave starts when matter is disturbed. A source of energy is needed to disturb matter and start a mechanical wave. Q: Where does the energy come from in the water wave pictured above? A: The energy comes from the falling droplets of water, which have kinetic energy because of their motion. The energy of a mechanical wave can travel only through matter. The matter through which the wave travels is called the medium (plural, media). The medium in the water wave pictured above is water, a liquid. But the medium of a mechanical wave can be any state of matter, even a solid. Q: How do the particles of the medium move when a wave passes through them? A: The particles of the medium just vibrate in place. As they vibrate, they pass the energy of the disturbance to the particles next to them, which pass the energy to the particles next to them, and so on. Particles of the medium dont actually travel along with the wave. Only the energy of the wave travels through the medium. There are three types of mechanical waves: transverse, longitudinal, and surface waves. They differ in how particles of the medium move. You can see this in the Figure 1.1. In a transverse wave, particles of the medium vibrate up and down perpendicular to the direction of the wave. In a longitudinal wave, particles of the medium vibrate back and forth parallel to the direction of the wave. In a surface wave, particles of the medium vibrate both up and down and back and forth, so they end up moving in a circle. Q: How do you think surface waves are related to transverse and longitudinal waves? A: A surface wave is combination of a transverse wave and a longitudinal wave.
Output: in which type of wave do particles of the medium move in small circles?
-Synuclein is an abundant presynaptic protein and a primary component of Lewy bodies in Parkinson disease. Although its pathogenic role remains unclear, in healthy nerve terminals -synuclein undergoes a cycle of membrane binding and dissociation. An -synuclein binding assay was used to screen for vesicle proteins involved in -synuclein membrane interactions and showed that antibodies directed to the Ras-related GTPase Rab3a and its chaperone RabGDI abrogated -synuclein membrane binding. Biochemical analyses, including density gradient sedimentation and co-immunoprecipitation, suggested that -synuclein interacts with membrane-associated GTP-bound Rab3a but not to cytosolic GDP-Rab3a. Accumulation of membrane-bound -synuclein was induced by the expression of a GTPase-deficient Rab3a mutant, by a dominant-negative GDP dissociation inhibitor mutant unable to recycle Rab3a off membranes, and by Hsp90 inhibitors, radicicol and geldanamycin, which are known to inhibit Rab3a dissociation from membranes. Thus, all treatments that inhibited Rab3a recycling also increased -synuclein sequestration on intracellular membranes. Our results suggest that membrane-bound GTP-Rab3a stabilizes -synuclein on synaptic vesicles and that the GDP dissociation inhibitorHsp90 complex that controls Rab3a membrane dissociation also regulates -synuclein dissociation during synaptic activity.
Output: Which is the primary protein component of Lewy bodies?
Tsunami are deadly ocean waves from the sharp jolt of an undersea earthquake. Less frequently, these waves can be generated by other shocks to the sea, like a meteorite impact. Fortunately, few undersea earthquakes, and even fewer meteorite impacts, generate tsunami. Tsunami waves have small wave heights relative to their long wavelengths, so they are usually unnoticed at sea. When traveling up a slope onto a shoreline, the wave is pushed upward. As with wind waves, the speed of the bottom of the wave is slowed by friction. This causes the wavelength to decrease and the wave to become unstable. These factors can create an enormous and deadly wave. Landslides, meteorite impacts, or any other jolt to ocean water may form a tsunami. Tsunami can travel at speeds of 800 kilometers per hour (500 miles per hour). Since tsunami are long-wavelength waves, a long time can pass between crests or troughs. Any part of the wave can make landfall first. In 1755 in Lisbon, Portugal, a tsunami trough hit land first. A large offshore earthquake did a great deal of damage on land. People rushed out to the open space of the shore. Once there, they discovered that the water was flowing seaward fast and some of them went out to observe. What do you think happened next? The people on the open beach drowned when the crest of the wave came up the beach. Large tsunami in the Indian Ocean and more recently Japan have killed hundreds of thousands of people in recent years. The west coast is vulnerable to tsunami since it sits on the Pacific Ring of Fire. Scientists are trying to learn everything they can about predicting tsunamis before a massive one strikes a little closer to home. Although most places around the Indian Ocean did not have warning systems in 2005, there is a tsunami warning system in that region now. Tsunami warning systems have been placed in most locations where tsunami are possible. Click image to the left or use the URL below. URL:
Output: tsunami can travel at speeds of
JMule is an open source file sharing client written in Java for eDonkey2000 networks.
Output: What is the programming language for JMule?
Sam Gillen (Van Damme) is a convict who gets sprung from Federal custody somewhere in the Midwest by his bank-robbing partner. In their last heist, Sam's partner killed a bank guard, and Sam took the rap for it. Sam's partner gets killed in the break, forcing Sam to go it alone in search of the loot, which is buried on the property of a farm inhabited by Clydie Anderson (Arquette), the widowed mother of two kids named Mike "Mookie" Anderson and Bree Anderson.Attempting to sneak into Clydie's house and "borrow" some salt for a campfire-broiled steak, Sam catches sight of Clydie taking a shower. The next morning, Sam is spotted bathing outdoors by Mookie. After saving Clydie, Mookie, and Bree from a trio of intruding thugs, Sam discovers that Clydie is holding out from selling her place to property developer Franklin Hale, who fears that he will be put out of business if he doesn't get Clydie's land so he can develop on it.Sam decides to hang around, sleeping first in Clydie's barn and then in her bed while repairing her late husband's Triumph motorcycle. And Hale hires an intimidation expert named Dunston, to force Clydie into selling her land. Secretly on Hale's payroll is corrupt sheriff Lonnie Cole, a sometime lover of Clydie.A jealous Lonnie discovers Sam's true identity and threatens to expose him if he doesn't leave. Not wanting to place Clydie in additional danger for helping a fugitive, Sam decides to leave, only to find that Hale has already blown the whistle on him in an attempt to get him out of the way. After evading police chasing him in cars, land rovers, helicopters, and on motorcycles and horseback, Sam returns to save Clydie from Dunston and Hale, who are planning to burn down her house.After fighting off the bad guys and getting Hale caught holding a gun to Clydie's head, he decides to turn himself in, rather than run away. He promises to be back to live with them.
Output: Who spots Sam bathing outdoors ?
A new report says promising children money to pass exams does not help exam grades. The report says parents could be wasting their money by using cash to get their kids to study more. However, the promise of a trip somewhere nice could encourage students to try harder and do better at school. Researchers from the University of Bristol (in England) and the University of Chicago (in the USA) looked at how promises of cash and tickets to events affected students' studying and learning. Over 10,000 pupils took part in the research throughout the year 2012. There was an improvement in classwork and homework, but this did not result in better test scores. Lead researcher Dr Simon Burgess suggested the research looked at the wrong areas. He said it had not looked at the things that really got students to increase their effort. He added that: "Clearly, some pupils have a lot of goals and believe that education is a way of getting what they want out of life, but there are kids who think that working hard doesn't make a difference." He said these children think exam success is "all in your genes" because of their family background. Education expert Dr Kevan Collins said good teachers were better than promises of rewards to get children to study, especially for children from low-income families. He wrote: "What really makes the difference is how students are taught."
Output: What do some students think is because of "your genes"?
Tommaso Maria Zigliara, OP (baptismal name: Francesco) (end of October 1833 -- 11 May 1893) was a Roman Catholic priest of the Dominican Order, a theologian, philosopher and a cardinal.
Output: What group was Tommaso Maria Zigliara a member of?
The week 3 matchup vs. the Texans proved to be a greater challenge for the Patriots than the Saints had been in week 2. The Patriots scored first on a 7-play drive ending with a Tom Brady 5-yard throw to Rob Gronkowski, who was playing with a groin injury that took him out of the previous week's game. The game would progress through seven lead changes, as Texans rookie quarterback DeShaun Watson would go drive-for-drive against Brady. Watson threw two touchdowns, one of which to his tight end Ryan Griffin, who attended college in New England at Connecticut. Two field goals late in the game would give the Texans their final lead at 33-28. With less than 2:25 remaining in the game, Brady led the Patriots on a frantic 8-play 71-yard drive that culminated in a 25-yard reception by Brandin Cooks to give the Patriots the 36-33 win.
Output: Which team did the patriots play in week 2?
Company in a courtyard behind a house (1663-1665) is an oil on canvas painting by the Dutch painter Pieter de Hooch, it is an example of Dutch Golden Age painting and is part of the collection of the Amsterdam Museum, on loan to the Rijksmuseum.
Output: What is the surface of Company in a courtyard behind a house made of?
ESSENTIALS: When high probability of pulmonary embolism (PE), sensitivity of computed tomography (CT) is unclear. We investigated the sensitivity of multidetector CT among 134 patients with a high probability of PE. A normal CT alone may not safely exclude PE in patients with a high clinical pretest probability. In patients with no clear alternative diagnosis after CTPA, further testing should be strongly considered. Whether patients with a negative multidetector computed tomographic pulmonary angiography (CTPA) result and a high clinical pretest probability of pulmonary embolism (PE) should be further investigated is controversial. This was a prospective investigation of the sensitivity of multidetector CTPA among patients with a priori clinical assessment of a high probability of PE according to the Wells criteria. Among patients with a negative CTPA result, the diagnosis of PE required at least one of the following conditions: ventilation/perfusion lung scan showing a high probability of PE in a patient with no history of PE, abnormal findings on venous ultrasonography in a patient without previous deep vein thrombosis at that site, or the occurrence of venous thromboembolism (VTE) in a 3-month follow-up period after anticoagulation was withheld because of a negative multidetector CTPA result. We identified 498 patients with a priori clinical assessment of a high probability of PE and a completed CTPA study. CTPA excluded PE in 134 patients; in these patients, the pooled incidence of VTE was 5.2% (seven of 134 patients; 95% confidence interval [CI] 1.5-9.0). Five patients had VTEs that were confirmed by an additional imaging test despite a negative CTPA result (five of 48 patients; 10.4%; 95% CI 1.8-19.1), and two patients had objectively confirmed VTEs that occurred during clinical follow-up of at least 3 months (two of 86 patients; 2.3%; 95% CI 0-5.5). None of the patients had a fatal PE during follow-up. A normal multidetector CTPA result alone may not safely exclude PE in patients with a high clinical pretest probability.
Output: What can be predicted with the Wells criteria?
Intevac, Inc. (NASDAQ: IVAC) is headquartered in Santa Clara, California in the Silicon Valley, with an office in Carlsbad, California as well.
Output: What stock exchange is most closely associated with Intevac?
Anemone (born 9 August 1950) is a French actress, filmmaker and political activist.
Output: What is the native tongue of Anémone?
Koo Ja-cheol (Hangul: ; born 27 February 1989) is a South Korean footballer who plays as midfielder for Bundesliga club FC Augsburg and the former captain of South Korean football team.
Output: In football, which position does Koo Ja-cheol play?
For their inaugural season, D.C. United Women's average home attendance for the 2011 season was over 800 fans, with D.C. United Women having five home games at the Maryland SoccerPlex.
Output: Where do D.C. United Women play their home games?
Robert le Coq (died 1373) was a French bishop and councillor.
Output: What is the position of Robert le Coq?
The Toucouleur Empire (also known as the Tijaniyya Jihad state or the Segu Tukulor) (1861-1890) was founded in the mid-nineteenth century by El Hadj Umar Tall of the Toucouleur people, in part of present-day Mali.
Output: What year was the end of Toucouleur Empire?
In 1740, the Mon of Lower Burma revolted against the Toungoo Dynasty and founded the Restored Hanthawaddy Kingdom based in Pegu . Throughout the 1740s, the Hanthawaddy forces were winning against Upper Burma-based Toungoo armies. The Siamese were concerned by another rising power in Burma since a strong Burma historically meant future invasions to Siam. Concerned, the Siamese court readily gave protection to the Burmese governors of Martaban and Tavoy who had fled to Siam. In 1745, they sent a diplomatic mission to Ava to evaluate the political situation there, and were received by the Burmese king Mahadhammaraza Dipadi. They saw an Ava court that was on its last legs. By 1751, Restored Hanthawaddy forces were closing in on Ava. The Siamese concerns about the emergence of another strong dynasty based in Pegu appeared imminent. Perhaps as a precautionary measure, the Siamese decided to move their forward base into the upper coast in 1751. While it remains unclear as to whether the Siamese ever intended to go beyond the coast into mainland Lower Burma, the Siamese action nonetheless rang alarm bells in Pegu. Deeply concerned, the Hanthawaddy leadership withdrew two-thirds of their army back down to Lower Burma immediately after they had toppled the last Toungoo king in April 1752. This redeployment of Hanthawaddy troops proved a critical turning point in Burmese history as it gave nascent Upper Burmese resistance groups much needed breathing room. The Hanthawaddy command left less than 10,000 men to pacify all of Upper Burma. Taking advantage of light Hanthawaddy troops, one resistance group, the Konbaung Dynasty led by Alaungpaya, drove out Hanthawaddy troops from Upper Burma by May 1754. Konbaung armies invaded Lower Burma in 1755, and captured Pegu in 1757, ending the 17-year-old Mon kingdom.
Output: Who sent a diplomatic mission to Ava in 1745?
Esporte Clube Sao Judas Tadeu play their home games at Estadio Municipal Alfredo Chiavegato.
Output: Where does Esporte Clube São Judas Tadeu play its game?
Tampa Bay won their second straight game, this one against a team that was highly favored to win. Jameis Winston threw for over 300 yards while Mike Evans received for over 100 yards. The offense was efficient, especially on third down where they went 11 of 15. The defense came up big as well, with safety Chris Conte getting an interception in the end zone, his second straight game with a pick. Rookie kicker Roberto Aguyao, who has struggled throughout the season, went 5/5 on kicks, making 4 field goals and 1 extra point. With this win, the Bucs got back to .500, took sole possession of second place in the NFC South, and improved their road record to 4-1.
Output: Who made one point
MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present the first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II). The primary miRNA transcripts (pri-miRNAs) contain cap structures as well as poly(A) tails, which are the unique properties of class II gene transcripts. The treatment of human cells with alpha-amanitin decreased the level of pri-miRNAs at a concentration that selectively inhibits pol II activity. Furthermore, chromatin immunoprecipitation analyses show that pol II is physically associated with a miRNA promoter. We also describe, for the first time, the detailed structure of a miRNA gene by determining the promoter and the terminator of mir-23a approximately 27a approximately 24-2. These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes.
Output: Which polymerase transcribes pri-miRNAs?
Selenoproteins are proteins containing an uncommon amino acid selenocysteine (Sec). Sec is inserted by a specific translational machinery that recognizes a stem-loop structure, the SECIS element, at the 3' UTR of selenoprotein genes and recodes a UGA codon within the coding sequence. As UGA is normally a translational stop signal, selenoproteins are generally misannotated and designated tools have to be developed for this class of proteins. Here, we present two new computational methods for selenoprotein identification and analysis, which we provide publicly through the web servers at [Link] or [Link] SECISearch3 replaces its predecessor SECISearch as a tool for prediction of eukaryotic SECIS elements. Seblastian is a new method for selenoprotein gene detection that uses SECISearch3 and then predicts selenoprotein sequences encoded upstream of SECIS elements. Seblastian is able to both identify known selenoproteins and predict new selenoproteins. By applying these tools to diverse eukaryotic genomes, we provide a ranked list of newly predicted selenoproteins together with their annotated cysteine-containing homologues. An analysis of a representative candidate belonging to the AhpC family shows how the use of Sec in this protein evolved in bacterial and eukaryotic lineages.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Frederik Helstrup Jensen (born 16 March 1993) is a Danish footballer who plays for Helsingborgs IF of the Allsvenskan in Sweden.
Output: What was the name of Frederik Helstrup's team?
Questions of if and when protein structures change within cells pervade biology and include questions of how the cytoskeleton sustains stresses on cells--particularly in mutant versus normal cells. Cysteine shotgun labeling with fluorophores is analyzed here with mass spectrometry of the spectrin-actin membrane skeleton in sheared red blood cell ghosts from normal and diseased mice. Sheared samples are compared to static samples at 37C in terms of cell membrane intensity in fluorescence microscopy, separated protein fluorescence, and tryptic peptide modification in liquid chromatography-tandem mass spectrometry (LC-MS/MS). Spectrin labeling proves to be the most sensitive to shear, whereas binding partners ankyrin and actin exhibit shear thresholds in labeling and both the ankyrin-binding membrane protein band 3 and the spectrin-actin stabilizer 4.1R show minimal differential labeling. Cells from 4.1R-null mice differ significantly from normal in the shear-dependent labeling of spectrin, ankyrin, and band 3: Decreased labeling of spectrin reveals less stress on the mutant network as spectrin dissociates from actin. Mapping the stress-dependent labeling kinetics of - and -spectrin by LC-MS/MS identifies Cys in these antiparallel chains that are either force-enhanced or force-independent in labeling, with structural analyses indicating the force-enhanced sites are sequestered either in spectrin's triple-helical domains or in interactions with actin or ankyrin. Shear-sensitive sites identified comprehensively here in both spectrin and ankyrin appear consistent with stress relief through forced unfolding followed by cytoskeletal disruption.
Output: Alpha-spectrin and beta-spectrin subunits form parallel or antiparallel heterodimers?
Activation of the superoxide-producing NADPH oxidase Nox1 requires both the organizer protein Noxo1 and the activator protein Noxa1. Here we describe an alternative splicing form of Noxo1, Noxo1gamma, which is expressed in the testis and fetal brain. The Noxo1gamma protein contains an additional five amino acids in the N-terminal PX domain, a phosphoinositide-binding module; the domain plays an essential role in supporting superoxide production by NADPH oxidase (Nox) family oxidases including Nox1, gp91(phox)/Nox2, and Nox3, as shown in this study. The PX domain isolated from Noxo1gamma shows a lower affinity for phosphoinositides than that from the classical splicing form Noxo1beta. Consistent with this, in resting cells, Noxo1gamma is poorly localized to the membrane, and thus less effective in activating Nox1 than Noxo1beta, which is constitutively present at the membrane. On the other hand, cell stimulation with phorbol 12-myristate 13-acetate (PMA), an activator of Nox1-3, facilitates membrane translocation of Noxo1gamma; as a result, Noxo1gamma is equivalent to Noxo1beta in Nox1 activation in PMA-stimulated cells. The effect of the five-amino-acid insertion in the Noxo1 PX domain appears to depend on the type of Nox; in activation of gp91(phox)/Nox2, Noxo1gamma is less active than Noxo1beta even in the presence of PMA, whereas Noxo1gamma and Noxo1beta support the superoxide-producing activity of Nox3 to the same extent in a manner independent of cell stimulation.
Output: Which NADPH oxidase family member requires interaction with NOXO1 for function?
John Edward Cain served in the California legislature and during World War I he served in the United States Army.
Output: Which war did John Edward Cain participate in?
The Paladin Hercules is an American powered parachute, designed and produced by Paladin Industries of Pennsauken, New Jersey.
Output: Which was the manufacturer of Paladin Hercules?
Swimming in the water of Hawaii's Big Island is a fun experience. But it can be more exciting if there are dolphins swimming around and jumping out of the sea too. For many people, it would be a wonderful dream to swim with these lovely animals! However, this may not be good for dolphins. They may get hurt because of human interaction . Dolphins are active and usually look for food at night. In the day, they like to rest in shallow bays . Many people think the dolphins are awake during the day as they swim. But when they sleep they rest half of their brain and keep the other half awake to breathe, so they may be sleeping even when they're swimming in the water. From 2010 to 2013, spinner dolphins of Hawaii's Big Island were exposed to human activities more than 82 percent of the time, according to Julian Tyne, a researcher at Australia's Murdoch University. The National Oceanic and Atmospheric Administration (NOAA) says disturbing the animals in their near-shore habitat could force them to swim to less favorable places, putting them at risk of attack by sharks and other animals. Besides, when people are around, dolphins become more active. Thus, they can't get enough sleep. "Disturbing their resting behaviors can actually affect their long term health and the health of the dolphin population," Ann Garrett of NOAA's National Marine Fisheries Service told the Associated Press. As a result, the NOAA wants to make rules to help protect the dolphins. For example, the agency may ban swimming with the Hawaii spinner dolphins. Or they may stop people from swimming in shallow bays when the dolphins are resting. Tour operators must also be taught to watch for signs to know when the dolphins are in their resting state.
Output: Which activity is against the rules?
Hyposmocoma menehune is a species of moth of the Cosmopterigidae family.
Output: Is Hyposmocoma menehune a genus or species?
The AJK Jaguars (Urdu: ) are a Pakistani men's professional Twenty20 cricket team that competes in the Haier T20 League and based in Mirpur, Azad Jammu and Kashmir, Pakistan.
Output: Which sport has connection with AJK Jaguars?