niryuu/sni-each-converted huggingface dataset:
To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis. Three multicenter, randomized, double-masked, placebo-controlled, dose-ranging phase III studies: SHIELD, INSURE, and ENDURE. A total of 118 patients with Behcet's uveitis (SHIELD study); 31 patients with active, noninfectious, non-Behcet's uveitis (INSURE study); and 125 patients with quiescent, noninfectious, non-Behcet's uveitis (ENDURE study) were enrolled. After an initial subcutaneous (s.c.) loading phase in each treatment arm, patients received s.c. maintenance therapy with secukinumab 300 mg every 2 weeks (q2w), secukinumab 300 mg monthly (q4w), or placebo in the SHIELD study; secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the INSURE study; or secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the ENDURE study. Reduction of uveitis recurrence or vitreous haze score during withdrawal of concomitant immunosuppressive medication (ISM). Other end points included best-corrected visual acuity, ISM use (expressed as a standardized ISM score), and safety outcomes. After completion or early termination of each trial, there were no statistically significant differences in uveitis recurrence between the secukinumab treatment groups and placebo groups in any study. Secukinumab was associated with a significant reduction in mean total post-baseline ISM score (P = 0.019; 300 mg q4w vs. placebo) in the SHIELD study. Likewise, secukinumab was associated with a greater median reduction in ISM score versus placebo in the INSURE study, although no statistical analysis of the difference was conducted because of the small sample size. Overall, there was no loss in visual acuity reported in any treatment group during follow-up in all 3 studies. According to descriptive safety statistics, the frequencies of ocular and nonocular adverse events seemed to be slightly higher among secukinumab groups versus placebo across the 3 studies. The primary efficacy end points of the 3 studies were not met. The secondary efficacy data from these studies suggest a beneficial effect of secukinumab in reducing the use of concomitant ISM.
Output: Which molecule is targeted by a monoclonal antibody Secukinumab?
One day, a slave owner entered a local store and threatened a young boy who was his slave. At first, the slave refused to move and ran for the door. The slave owner reached for a heavy weight. He threw it at his slave. Instead, it hit Harriet on the head. Harriet almost died. For the rest of her life, she carried the mark of a deep wound on her head. Miser Brodas felt he never needed Harriet. He decided to sell her. Harriet thought of a way to prevent this. Each time she was shown to someone who might buy her, she acted as if she were falling asleep. After a while, Mister Brodas gave up the hope of selling Harriet. He sent her back to the fields. At 24 she married a free black man, John Tubman. By then, Harriet was sure she should escape. In 1849, Mister Brodas died. His slaves probably would be sold to further South. John Tubman tried to make Harriet forget about running away. Harriet decided she must end her marriage and that she needed to tell her family that she was leaving. Harriet escaped for Pennsylvania where slavery was banned there. Once she hid under hay that had been cut from the fields. Another time, she wore men's clothing. Finally, she arrived in Pennsylvania. Now that Harriet was free, she didn't forget other slaves in Maryland. During the next ten years, she freed her parents and other family members. She traveled back and forth eighteen times, helping about 300 slaves escape. She became an expert at hiding from slave hunters. At one time, anyone finding Harriet was promised 40,000dollars for catching her--dead or alive. The people she helped called her Moses. She had rescued them from slavery just as the biblical Moses rescued the Jews. After the Civil War began, Harriet started to spy for the North. She also served as a nurse. After four years of bloody fighting, the North won the war. Abraham Lincoln freed the slaves in 1863. There was no longer any need for Harriet to be Moses.
Output: We know from the passage that Harriet was Mister Brodas'    .
Between 1952 and 1989 the university was named Bolesaw Bierut University of Wrocaw (Polish: Uniwersytet Wrocawski im. Bolesawa Bieruta) after Bolesaw Bierut, President of the Republic of Poland (1947--52).
Output: Whom is University of Wrocław named after?
Notice Dear Degree-doing International Students, According to the University's regulations governing the Curriculums of General Education, the curriculum-choosing procedures are as follows: Who All degree-doing international students are required to choose the curriculums related to Chinese Language and Culture. Refer to Item 3 for different arrangements for undergraduate students ,master and doctor students. What curriculum to choose You are required to choose two curriculums related to Chinese Language and Culture that suit your own level and program. The curriculum consists of Elementary Chinese, Intermediate Chinese, and Chinese Culture (Taught in Chinese and English ). Please refer to Attachment 1 for details. How many credits You are required to complete 6 credits for each curriculum within a term. When and How A. Undergraduate students: you are required to complete the curriculum selection process (The system will be reopened next week) by 5:00 p.m. on June 22, 2013. About how to choose the courses, you can refer to Attachment 2 (It is in Chinese; turn to your Chinese friends or teachers for help if you cannot follow the procedures of the attachment) for the instructions. B. Master and Doctor Students: you won't have to complete the curriculum selection until early September; please wait for further notice on the arrangement. Your cooperation will be highly appreciated. Attachment 1: Chinese Language & Culture for International Students Attachment 2: Handbook for Curriculum Selection School of International Education Chongqing University June 13, 2013
Output: According to the arrangement, who must finish choosing curriculums in June?
People depend on natural resources for just about everything that keeps us fed and sheltered, as well as for the things that keep us entertained. Every person in the United States uses about 20,000 kilograms (40,000 pounds) of minerals every year for a wide range of products, such as cell phones, TVs, jewelry, and cars. Table 1.1 shows some common objects, the materials they are made from, and whether they are renewable or non-renewable. Common Object Natural Resources Used Cars 15 different metals, such as iron, lead, and chromium to make the body. Precious metals like gold, silver, and platinum. Gems like diamonds, rubies, emer- alds, turquoise. Jewelry Are These Resources Renewable or Non-Renewable? Non-renewable Non-renewable Common Object Natural Resources Used Electronic Appliances (TVs, com- puters, DVD players, cell phones, etc.) Clothing Many different metals, like copper, mercury, gold. Food Bottled Water Gasoline Household Electricity Paper Houses Soil to grow fibers such as cotton. Sunlight for the plants to grow. Animals for fur and leather. Soil to grow plants. Wildlife and agricultural animals. Water from streams or springs. Petroleum products to make plastic bottles. Petroleum drilled from wells. Coal, natural gas, solar power, wind power, hydroelectric power. Trees; Sunlight Soil. Trees for timber. Rocks and minerals for construc- tion materials, for example, granite, gravel, sand. Are These Resources Renewable or Non-Renewable? Non-renewable Renewable Renewable Non-renewable and Renewable Non-renewable Non-renewable and Renewable Renewable Non-renewable and Renewable Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:
Output: which common object is made mostly or entirely from renewable resources?
The 1974 Norfolk mid-air collision happened on 9 August 1974 at Fordham Fen, Norfolk, England when a Royal Air Force McDonnell-Douglas Phantom FGR2 of 41 Squadron collided with a Piper Pawnee crop spraying aircraft.
Output: The point in time of 1974 Norfolk mid-air collision was when?
Antibody-mediated glomerulonephritis, including that resulting from immune complexes, is an important cause of renal failure and is in need of more specific and effective treatment. Binding of antibody or immune complexes to Fc receptors activates intracellular signal transduction pathways, including spleen tyrosine kinase (Syk), leading to the production of inflammatory cytokines. We examined the effect of R788 (fostamatinib disodium), an oral prodrug of the selective Syk inhibitor R406, in nephrotoxic nephritis in Wistar-Kyoto rats. Treatment with R788 reduced proteinuria, tissue injury, glomerular macrophage and CD8+ cell numbers, and renal monocyte chemoattractant protein-1 (MCP-1) and IL-1beta, even when we started treatment after the onset of glomerulonephritis. When we administered R788 from days 4 to 10, glomerular crescents reduced by 100% (P < 0.01) compared with the vehicle group. When we administered R788 treatment from days 7 to 14, established glomerular crescents reversed (reduced by 21%, P < 0.001), and renal function was better than the vehicle group (P < 0.001). In vitro, R406 downregulated MCP-1 production from mesangial cells and macrophages stimulated with aggregated IgG. These results suggest that Syk is an important therapeutic target for the treatment of glomerulonephritis.
Output: Which enzyme is inhibited by a drug fostamatinib?
For electric current to flow through a wire, there must be a source of voltage. Voltage is a difference in electric potential energy. As you might have guessed, greater voltage results in more current. As electric current flows through matter, particles of matter resist the moving charges. This is called resistance, and greater resistance results in less current. These relationships between electric current, voltage, and resistance were first demonstrated in the early 1800s by a German scientist named Georg Ohm, so they are referred to as Ohms law. Ohms law can be represented by the following equation. Current(amps) = Voltage(volts) Resistance(ohms) Ohms law may be easier to understand with an analogy. Current flowing through a wire is like water flowing through a hose. Increasing voltage with a higher-volt battery increases the current. This is like opening the tap wider so more water flows through the hose. Increasing resistance reduces the current. This is like stepping on the hose so less water can flow through it. You can use the equation for current (above) to calculate the amount of current flowing through a circuit when the voltage and resistance are known. Consider an electric wire that is connected to a 12-volt battery. If the wire has a resistance of 2 ohms, how much current is flowing through the wire? Current = 12 volts 2 ohms = 6 amps Q: If a 120-volt voltage source is connected to a wire with 10 ohms of resistance, how much current is flowing through the wire? A: Substitute these values into the equation for current: Current = 120 volts 10 ohms = 12 amps
Output: the amount of current flowing through a wire will be less when there is greater
People without homes have always been present in America. In the past,they were called hobos,bums,or drifters. It was not until the early 1980s that these people received a new name,when activists named them the homeless. The types of people who were homeless also changed in the 1980s. No longer were they primarily older men. They were younger,with an average age of 35. Their numbers consisted of women,children,adolescents and entire families. They were of many races and cultures. No longer were they only in the inner city. They lived in rural areas and in large and small cities. No longer were they invisible to the people with homes and jobs. The homeless of the 1980s lived in packing crates and doorways. They slept on sidewalks and in public parks. They begged money from passersby. Counting the numbers of homeless people is difficult. However,in 1984 the Department of Housing and Urban Development estimated the homeless population at between 250,000 and 350,000. In 1990 the Census Bureau counted about 459,000 people in shelters,in cheap hotels,and on the streets. In 1995 the National Alliance to End Homelessness estimated that there were 750,000 homeless Americans. The homeless of the 1980s also began to speak out for themselves. Some spoke to Congress and to government committees controlling funding for social programs. Street newspapers,such as Chicago's Streetwise and Boston's Spare Change,had stories,poems,and essays that expressed the homeless viewpoint. The visible and vocal presence of the homeless prompted help from volunteers and government agencies. But what is still needed is a solution to the _ of America's homeless population.
Output: Who is responsible to get the number of the homeless population according to the passage?
Gerard Debreu (French: (db); 4 July 1921 -- 31 December 2004) was a French-born American economist and mathematician.
Output: What is the birth date of Gérard Debreu?
Caecilia isthmica is a species of amphibian in the Caeciliidae family.
Output: Is the taxon rank of Caecilia isthmica species or genus?
9767 Midsomer Norton (1992 EB1) is an outer main-belt asteroid discovered on March 10, 1992 by Duncan Steel at Siding Spring.
Output: Who made the discovery of 9767 Midsomer Norton?
Epidermal growth factor receptor (EGFR) gene mutations have been found in a subset of non-small cell lung cancer (NSCLC) with good clinical response to gefitinib therapy. A quick and sensitive method with large throughput is required to utilize the information to determine whether the molecular targeted therapy should be applied for the particular NSCLC patients. Using probes for the 13 different mutations including 11 that have already been reported, we have genotyped the EGFR mutation status in 94 NSCLC patients using the TaqMan PCR assay. We have also genotyped the EGFR mutations status in additional 182 NSCLC patients, as well as 63 gastric, 95 esophagus and 70 colon carcinoma patients. In 94 NSCLC samples, the result of the TaqMan PCR assay perfectly matched with that of the sequencing excluding one patient. In one sample in which no EGFR mutation was detected by direct sequencing, the TaqMan PCR assay detected a mutation. This patient was a gefitinib responder. In a serial dilution study, the assay could detect a mutant sample diluted in 1/10 with a wild-type sample. Of 182 NSCLC samples, 46 mutations were detected. EGFR mutation was significantly correlated with gender, smoking status, pathological subtypes, and differentiation of lung cancers. There was no mutation detected by the TaqMan PCR assay in gastric, esophagus and colon carcinomas. TaqMan PCR assay is a rapid and sensitive method of detection of EGFR mutations with high throughput, and may be useful to determine whether gefitinib should be offered for the treatment of NSCLC patients. The TaqMan PCR assay can offer us a complementary and confirmative test.
Output: Mutations in which gene determine response to both erlotinib and gefitinib?
The 2016 Conference on Retroviruses and Opportunistic Infections (CROI) highlighted hot spots in HIV infection. Men who have sex with men (MSM), transgender populations, people who inject drugs, fisherfolk, migrants, adolescents, and older adults are heavily impacted in a number of regions. Stigma contributes to risk behaviors and HIV acquisition across populations. HIV testing is a crucial first step in the HIV care continuum, and several large community-based surveys are underway in Africa to increase HIV testing, linkage to care, and uptake of antiretroviral treatment. Advances in preexposure prophylaxis (PrEP) featured prominently at CROI 2016. Two large efficacy trials of a vaginal ring containing the investigational drug dapivirine demonstrated efficacy and safety in preventing HIV infections in women in Africa. Data on the safety of long-acting injectable PrEP and several investigational PrEP drugs and formulations were also presented. Knowledge and use of PrEP among MSM in the United States appears to be increasing, and high uptake was seen among black MSM when provided as part of a culturally tailored support program. The use of broadly neutralizing antibodies for HIV prevention is a novel and promising approach to be evaluated in efficacy trials.
Output: Which infection can be prevented with Dapivirine?
Malaysia Airlines Berhad (MAB) (Malay: Penerbangan Malaysia Berhad) formerly known as Malaysian Airline System Berhad (MAS; Malay: Sistem Penerbangan Malaysia); branded as Malaysia Airlines; (Malay: Penerbangan Malaysia; MYX: 3786 as Malaysian Airline System Berhad) is a major airline operating flights from Kuala Lumpur International Airport and from secondary hubs in Kota Kinabalu and Kuching to destinations throughout Asia as well as a handful of destinations in Europe and Oceania.
Output: At what airport can you find Malaysia Airlines?
Varespladib methyl is an oral secretory phospholipase A2 inhibitor that is being developed by Anthera Pharmaceuticals Inc for the potential treatment of coronary artery disease, acute coronary syndrome and inflammation. Varespladib methyl is a prodrug that is rapidly metabolized to varespladib, and both compounds are able to potently inhibit the enzymes of the human secretory phospholipase groups IIa, V and X, which play a pivotal role in atherosclerotic disease and inflammation. Phase II clinical trials of varespladib methyl in patients with coronary artery disease, rheumatoid arthritis, asthma and ulcerative colitis revealed that the drug was well tolerated. Varespladib methyl did not demonstrate a good efficacy profile in patients with rheumatoid arthritis, asthma and ulcerative colitis, whereas in patients with coronary artery disease, varespladib methyl consistently reduced LDL-cholesterol levels (elevated LDL-cholesterol levels are a marker of increased cardiovascular risk). At the time of publication, phase II trials were ongoing in patients with acute coronary syndrome and in patients undergoing elective percutaneous coronary intervention, and a phase III trial in patients with acute coronary syndrome was planned. Varespladib methyl could represent a novel therapy for the treatment of cardiovascular disease, although the efficacy, safety profile and advantages of this drug compared with existing therapeutic options would need to be established in upcoming phase III trials.
Output: Which enzyme is inhibited by Varespladib?
The Internet can be a great way to connect with people. The latest web craze is social networking on websites such as MySpace. More than 65 million young people use online social networking sites. That cyberspace trend is causing problems in school, however. In a recent survey, nearly 36 percent of school administrators said that social networking sites troubled learning in their districts. Should school districts ban sites like MySpace? Teachers are worried that some students use social networking to post personal information and to cyber bully other students. One of the biggest dangers comes from people who find out kid's personal information. Many districts have blocked students from accessing or using social networking sites from school computers, and some have suspended students for posting harmful material on those sites from their home computers. Nearly two-thirds of US kids have computers in their homes, according to the US Census Bureau. "It is important to keep in mind that just blocking access to social web sites at school is not the end of the story," warns NSBA executive director Anne Bryant, "Most of the misuse of these sites takes place at home but still affects the classroom." _ . They say the main problem with sites like MySpace is that students don't understand the dangers involved in using them. "Many students are posting personal information about themselves without regard to who has access to that information," Jim Hirsch said, "Schools should focus on educating their students and their parents on how to be safe online." Experts argue that too many schools are forbidding students to use social networking web sites without thinking about their educational benefits. "Social networking web sites can help connect students in the United States to their peers in other countries, providing invaluable lessons in foreign cultures," explains Hirsch.
Output: Where do students usually misuse social networking sites?
Canonical primary microRNA (pri-miRNA) precursors are transcribed by RNA polymerase II and then processed by the Drosha endonuclease to generate approximately 60 nt pre-miRNA hairpins. Pre-miRNAs in turn are cleaved by Dicer to generate mature miRNAs. Previously, some short introns, called miRtrons, were reported to fold into pre-miRNA hairpins after splicing and debranching, and miRNAs can also be excised by Dicer cleavage of rare endogenous short hairpin RNAs. Here we report that the miRNAs encoded by murine gamma-herpesvirus 68 (MHV68) are also generated via atypical mechanisms. Specifically, MHV68 miRNAs are transcribed from RNA polymerase III promoters located within adjacent viral tRNA-like sequences. The resultant pri-miRNAs, which bear a 5' tRNA moiety, are not processed by Drosha but instead by cellular tRNase Z, which cleaves 3' to the tRNA to liberate pre-miRNA hairpins that are then processed by Dicer to yield the mature viral miRNAs.
Output: Which polymerase transcribes pri-miRNAs?
In 1977, Hawker Siddeley became a founding component of the nationalised British Aerospace (BAe).
Output: By what was Hawker Siddeley replaced?
In a phase I study, Gilead Sciences' PI3K- inhibitor idelalisib produced rapid tumor shrinkage-a response that lasted for 17 months on average-in about half of the 54 patients with chronic lymphocytic leukemia who participated.
Output: What is the target protein of the drug Idelalisib?
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebrovascular disease leading to accumulating neurologic deficits and dementia. CADASIL has been linked to nucleotide substitutions and deletions in the Notch3 gene. All the mutations described until now lead to unpaired cysteine residue in the epidermal growth factor-like repeats. The authors report a family with CADASIL carrying a deletion in the Notch3 gene that did not involve a cysteine residue.
Output: Which amino acid residue appears mutated in most of the cases reported with  cadasil syndrome?
FC Echallens play their home games at Sportplatz 3 Sapins in Echallens.
Output: What is the common name of the place where FC Echallens plays their home games?
Acromicric dysplasia is a rare bone dysplasia characterised by short stature, short hands and feet, normal intelligence, mild facial dysmorphism, and characteristic x ray abnormalities of the hands. Only a very small number of children with this condition have been reported so far. Here we report on a series of 22 patients including 10 boys and 12 girls with acromicric dysplasia. Length was normal at birth and height fell progressively off the centiles postnatally. The mean adult height was 130 cm (133 cm in males, 129 cm in females). The hands, feet, and limbs were short and OFC was normal. Intelligence was normal and mild dysmorphic features were noted. Other occasional features included well developed muscles, a hoarse voice, generalised joint limitation in some patients, frequent ear, tracheal, and respiratory complication, and spine abnormalities. Long term follow up showed that facial dysmorphism was less obvious in adults and that carpal tunnel syndrome was frequent in older patients. Apart from short metacarpals and phalanges, internal notch of the second metacarpal, external notch of the fifth metacarpal, and internal notch of the femoral heads, there were no major x ray abnormalities. No major complications, such as cardiac disease or major orthopaedic problems, occurred in the course of the disease. The condition appeared to be sporadic in 16 cases but the observation of vertical transmission in three families was consistent with an autosomal dominant mode of inheritance.
Output: What is the mode of inheritance of Acromicric dysplasia?
Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike other histone methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal histone H3. We have solved a 2.5 A resolution structure of the catalytic domain of human Dot1, hDOT1L, in complex with S-adenosyl-L-methionine (SAM). The structure reveals a unique organization of a mainly alpha-helical N-terminal domain and a central open alpha/beta structure, an active site consisting of a SAM binding pocket, and a potential lysine binding channel. We also show that a flexible, positively charged region at the C terminus of the catalytic domain is critical for nucleosome binding and enzymatic activity. These structural and biochemical analyses, combined with molecular modeling, provide mechanistic insights into the catalytic mechanism and nucleosomal specificity of Dot1 proteins.
Output: What is the characteristic domain of histone methyltransferases?
Stories in Boxes: Britain performing artist Bobby Baker will present Box Story to conclude the UK performing Arts Festival. Her performances cover various aspects of life: including health, shopping, and educating children. She explores these themes with originality and "outside the square". Time: 7:30 pm, December 3-5 Place: North Theater, Beibingmasi Lane, Jiaodaokou, Dongcheng District Tel: 8602-4898 Elvis Story: Le Caoitole De Quebee will bring its production The Elvis Storyto Beijing audiences this month. This remarkable musical production relates the best moments of Elvis Preeley's life and his career. The show is a musical reconstitution of the life of a singer who revolutionized American popular music and become the most famous rock star of the 20th century. Time: 7:30 pm, November 25-28 Place: Poly Theater, Dongsishitiao Tel: 6506-5343, 6413-1321 Soldier's musical: A Soldier's Diary, a Chinese musical describing the life of contemporary soldiers in China, is to be staged for 12 performances by the Song and Dance Essembles of the Political of the Chinese People Liberation Army . Time: 7:30 pm, November 29-December15 Place: China Theatre, Xisanhuan Beilu, Handian District Tel: 6843-0560 Social tolerance: The Italian opera Pagliacci, by Ruggero Leoneavallo ( 1856--1919), is to premiere , performed by Chinese opera singers from China's Central Opera Theatre. A violent opera exploring the limits of social tolerance, the opera premiered in 1892 and gained popularity throughout Europe and America. Within two years, it had been translated into all major European languages including Swedish, Serbo-Croatian and Hebrew. Leoneavallo was a prolific writer, yet none of his other works ever matched the popularity of this opera. Chinese vocal artists include Huang Yuefeng, Wang Feng, Sun Xiewei, Gao Lei and Shen Na, Li Wei is to conduct.. Time: 7:30 pm, November 27 Place: Peking University Concert Hall, Peking University Tel: 6275-1278, 6551-4787
Output: Which performance covers the life of contemporary soldiers in China?
P&O European Ferries (formerly Townsend Thoresen), a division of P&O Ferries, was a ferry company which operated in the English Channel from 1987 after the Herald of Free Enterprise disaster, when Townsend Thoresen was renamed P&O European Ferries, until 1999 when the Portsmouth Operations became P&O Portsmouth and the Dover Operation where merged with Stena Line AB to make P&O Stena Line.
Output: What is the ending year of P&O European Ferries?
Eduardo Maiorino de Morais was born in Campo Grande, Mato Grosso do Sul, Brazil and died December 23, 2012, after a heart attack.
Output: What was the cause of death for Eduardo Maiorino?
The War of the Guelderian Succession was a battle for the throne of the Duchy of Guelders that raged between 1371 and 1379.
Output: On what date did War of the Guelderian Succession end?
Parkinson's disease (PD) is characterized by the progressive loss of substantia nigra dopaminergic neurons and the presence of cytoplasmic inclusions named Lewy bodies. Two missense mutations of the alpha-synuclein (alpha-syn; A30P and A53T) have been described in several families with an autosomal dominant form of PD. alpha-Syn also constitutes one of the main components of Lewy bodies in sporadic cases of PD. To develop an animal model of PD, lentiviral vectors expressing different human or rat forms of alpha-syn were injected into the substantia nigra of rats. In contrast to transgenic mice models, a selective loss of nigral dopaminergic neurons associated with a dopaminergic denervation of the striatum was observed in animals expressing either wild-type or mutant forms of human alpha-syn. This neuronal degeneration correlates with the appearance of abundant alpha-syn-positive inclusions and extensive neuritic pathology detected with both alpha-syn and silver staining. Lentiviral-mediated expression of wild-type or mutated forms of human alpha-syn recapitulates the essential neuropathological features of PD. Rat alpha-syn similarly leads to protein aggregation but without cell loss, suggesting that inclusions are not the primary cause of cell degeneration in PD. Viral-mediated genetic models may contribute to elucidate the mechanism of alpha-syn-induced cell death and allow the screening of candidate therapeutic molecules.
Output: Which is the primary protein component of Lewy bodies?
Pasta is the world's favorite food. Asurveytaken in 17 countriesconfirmedthat pasta is what people like to eat most. Not only is pasta the number one food in its home country -Italy, but is alsoenjoyedin faraway places like the Philippines, Mexico andSouth Africa. Pasta has become popular, for one thing, because it is cheap and easy to prepare. Just cook noodles or other forms of pasta, make a sauce to go with it and you're finished. Many different types of meals can becreatedwith pasta. It tastes good and fills your stomach. It produces energy in the form ofcarbohydrates , which is whyathleteseat pasta regularly. Pasta can also be kept for a longer time. You don't have to use it up at once. Pasta has also become popular because it stands for the Italian way of life. People all over the world like it because it's so simple. It has two basic ingredients , wheatand water, just like bread. Legend has itthat Marco Polo brought pasta back to Italy with him but this is not true. Arabs probably brought a noodle-likedishtoSicilyin the 8th century. Farmers have been growing wheat, the mainingredientof pasta, there for ages. The worldwide sales of pasta have risen sharply over the past decade. Italy leads the pasta-eatingcommunityof the world. The Italians are the number one consumers followed by Venezuela and Tunisia.
Output: In which country do people eat pasta most?
To compare the outcome of outside-in biological and synthetic transobturator tape (TOT) operation, including subjective and objective success rates, urodynamics, and quality of life. One hundred patients suffering from clinical and/or urodynamic stress urinary incontinence (SUI) were randomized into biological material TOT (PELVILACE® TO) or synthetic material TOT (ALIGN®TO Urethral Support System) groups. Preoperative and at 1 year postoperative urogynecological symptom assessment, 1-h pad test, 4-day bladder diary, stress test, Q-tip test, and urodynamics were performed. For the evaluation of quality of life, the King's Health Questionnaire, Urogenital Distress Inventory-6, Incontinence Impact Questionnaire-7, and Prolapse Quality of Life were used. There was no significant difference between the two groups regarding objective and subjective cure rates and quality of life. At 1-year follow-up, the subjective cure rate was 68 % in the biological material TOT and 70 % in the synthetic material TOT group. No perioperative complications developed. Groin pain developed in 2 patients in the biological TOT group and 1 patient had dehiscence in the periurethral incision, which healed with local estrogen. Two patients had transient urinary retention in the synthetic TOT group, 1 patient developed groin pain, and 1 patient had mesh erosion observed at the 1-year follow-up. Transobturator tape with biological material in the management of SUI has a rate of success and patient satisfaction similar to those of synthetic material at 1-year follow-up. Studies with longer follow-up and larger cohorts are necessary to evaluate possible autolysis and degradation of biological slings and a possible reduction in efficacy over time.
Output: Which type of urinary incontinence is diagnosed with the Q tip test?
Hoping to rebound from their road loss to the Steelers, the Browns went home for a Week 7 interconference duel with the Green Bay Packers. After a scoreless first quarter, Cleveland began the second quarter with kicker Billy Cundiff's 22-yard field goal. However, the Packers would take charge with quarterback Aaron Rodgers completing a 45-yard touchdown pass to tight end Spencer Havner and a 71-yard touchdown pass to wide receiver Donald Driver, followed by a 1-yard touchdown run by running back Ryan Grant. Afterwards, Green Bay pulled away in the second half with kicker Mason Crosby booting an 18-yard field goal in the third quarter and Rodgers finding wide receiver James Jones on a 5-yard touchdown pass.
Output: Which team scored first?
Treat with Respect The speed with which Man is changing the face of Earth has outstripped all the mighty processes of nature put together. In his haste to supply himself with increasing quantities of Earth's treasures he risks destroying one he greatly needs, his natural surroundings. Some countries set aside unspoiled areas of natural beauty. prefix = st1 /Canadahas the largest system of national parks in the world, 29 in all covering about 13 million hectares, preserving the different landscapes and the plant and animal life. Other countries are restoring areas which have been reduced to waste land by mining. At Broken Hill in Australiadrifting sand from rock crushing turned the area into a desert swept by sand storms. This is now being irrigated, fertilized and planted with grass and trees. In Great Britain quarries and gravel pits are being filled in or made into lakes, industrial wasteland is being turned into playing fields and waste tips into sloping green hills. However Man tries to look after Earth, the fact is that he is using up at a great rate resources, especially fuel resources, which have taken millions of years to accumulate and which he cannot renew. Yet every day the Earth receives a huge supply of energy from the Sun. Man has made several experiments in using solar energy to heat furnaces , cookers, and water-distillers. In space technology, e.g. on satellites, solar cells convert sunlight into electricity. Houses and offices have been designed which are centrally heated by water or air heated by the sunlight. When Man can trap and store this energy, so that he can use it exactly as he needs it, he will have not only an endless supply, but a clean and safe one.
Output: According to this selected passage, which energy is considered to be endless, clean and safe?
For travellers who want to experience some of the history and mystery of the ancient world, here is a list of cool destinations for your next holiday. Angkor Wat, Cambodia Built in the 12th century, Angkor Wat (meaning "capital monastery") was a temple in the ancient Khmer capital city of Angkor. It is Cambodia's best-known tourist attraction and is famed for its beautiful architecture and reliefs. You'll need at least three days to fully discover the delights of this magnificent site. Machu Picchu, Peru Machu Picchu was built high in the Andes Mountains of South America by the Inca in the 15th century. Although well preserved its exact purpose is unknown. It is famous throughout the world not only for its incredible design but also for the natural beauty that surrounds it. Give yourself a week to explore this magnificent site. Stonehenge, England The entire Stonehenge site was constructed over thousands of years. But why and how it was built remains a mystery. As the weather can be pretty bleak in winter and the crowds huge in summer, we suggest autumn should be the best time to visit these monster rocks. Pompeii, Italy When Mount Vesuvius erupted in 79 A.D., Pompeii was buried under many layers of ash, preserving the city exactly as it was when the volcano erupted. Because so many objects were preserved, scientists and visitors are able to better understand daily life in the ancient Roman Empire.
Output: Which location offers the most direct view into daily life in the ancient world?
How high or low a sound seems to a listener is its pitch. Pitch, in turn, depends on the frequency of sound waves. Wave frequency is the number of waves that pass a fixed point in a given amount of time. High-pitched sounds, like the sounds of the piccolo in the Figure 1.1, have high-frequency waves. Low-pitched sounds, like the sounds of the tuba Figure 1.1, have low-frequency waves. The frequency of sound waves is measured in hertz (Hz), or the number of waves that pass a fixed point in a second. Human beings can normally hear sounds with a frequency between about 20 Hz and 20,000 Hz. Sounds with frequencies below 20 hertz are called infrasound. Infrasound is too low-pitched for humans to hear. Sounds with frequencies above 20,000 hertz are called ultrasound. Ultrasound is too high-pitched for humans to hear. Some other animals can hear sounds in the ultrasound range. For example, dogs can hear sounds with frequencies as high as 50,000 Hz. You may have seen special whistles that dogsbut not peoplecan hear. The whistles produce sounds with frequencies too high for the human ear to detect. Other animals can hear even higher-frequency sounds. Bats, like the one pictured in the Figure 1.2, can hear sounds with frequencies higher than 100,000 Hz! Q: Bats use ultrasound to navigate in the dark. Can you explain how? A: Bats send out ultrasound waves, which reflect back from objects ahead of them. They sense the reflected sound waves and use the information to detect objects they cant see in the dark. This is how they avoid flying into walls and trees and also how they find flying insects to eat.
Output: what is the highest-frequency sound that humans normally can hear?
Sitakunda massacre (Bengali: ) refers to the massacre of Hindu pilgrims on 15 February 1950.
Output: The date of Sitakunda massacre was what?
The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential component of the centrosome, underlying eukaryotic microtubule-based motility, cell division and polarity. In recent years, components of the CBB-assembly machinery have been identified, but little is known about their regulation and evolution. Given the diversity of cellular contexts encountered in eukaryotes, but the remarkable conservation of CBB morphology, we asked whether general mechanistic principles could explain CBB assembly. We analysed the distribution of each component of the human CBB-assembly machinery across eukaryotes as a strategy to generate testable hypotheses. We found an evolutionarily cohesive and ancestral module, which we term UNIMOD and is defined by three components (SAS6, SAS4/CPAP and BLD10/CEP135), that correlates with the occurrence of CBBs. Unexpectedly, other players (SAK/PLK4, SPD2/CEP192 and CP110) emerged in a taxon-specific manner. We report that gene duplication plays an important role in the evolution of CBB components and show that, in the case of BLD10/CEP135, this is a source of tissue specificity in CBB and flagella biogenesis. Moreover, we observe extreme protein divergence amongst CBB components and show experimentally that there is loss of cross-species complementation among SAK/PLK4 family members, suggesting species-specific adaptations in CBB assembly. We propose that the UNIMOD theory explains the conservation of CBB architecture and that taxon- and tissue-specific molecular innovations, gained through emergence, duplication and divergence, play important roles in coordinating CBB biogenesis and function in different cellular contexts.
Output: Where in the cell do we find the protein Cep135?
''In the Hands of the Prophets'' is the twentieth and final episode of the first season of the American science fiction television series Star Trek: Deep Space Nine.
Output: Which series is In the Hands of the Prophets apart of?
A change in an objects motionsuch as Xander speeding up on his scooteris called acceleration. Acceleration occurs whenever an object is acted upon by an unbalanced force. The greater the net force acting on the object, the greater its acceleration will be, but the mass of the object also affects its acceleration. The smaller its mass is, the greater its acceleration for a given amount of force. Newtons second law of motion summarizes these relationships. According to this law, the acceleration of an object equals the net force acting on it divided by its mass. This can be represented by the equation: Acceleration = Net force Mass or a = F m This equation for acceleration can be used to calculate the acceleration of an object that is acted on by a net force. For example, Xander and his scooter have a total mass of 50 kilograms. Assume that the net force acting on Xander and the scooter is 25 Newtons. What is his acceleration? Substitute the relevant values into the equation for acceleration: F = 25 N = 0.5 N a= m 50 kg kg The Newton is the SI unit for force. It is defined as the force needed to cause a 1-kilogram mass to accelerate at 1 m/s2 . Therefore, force can also be expressed in the unit kg m/s2 . This way of expressing force can be substituted for Newtons in Xanders acceleration so the answer is expressed in the SI unit for acceleration, which is m/s2 : 2 0.5 kgm/s a = 0.5kgN = = 0.5 m/s2 kg Q: Why are there no kilograms in the final answer to this problem? A: The kilogram units in the numerator and denominator of the fraction cancel out. As a result, the answer is expressed in the correct SI units for acceleration. Its often easier to measure the mass and acceleration of an object than the net force acting on it. Mass can be measured with a balance, and average acceleration can be calculated from velocity and time. However, net force may be a combination of many unseen forces, such as gravity, friction with surfaces, and air resistance. Therefore, it may be more useful to know how to calculate the net force acting on an object from its mass and acceleration. The equation for acceleration above can be rewritten to solve for net force as: Net Force = Mass Acceleration, or F=ma Look at Xander in the Figure 1.1. Hes riding his scooter down a ramp. Assume that his acceleration is 0.8 m/s2 . How much force does it take for him to accelerate at this rate? Substitute the relevant values into the equation for force to find the answer: F = m a = 50 kg 0.8 m/s2 = 40 kg m/s2 , or 40 N Q: If Xander and his scooter actually had a mass of 40 kg instead of 50 kg, how much force would it take for him to accelerate at 0.8 m/s2 ?
Output: for a given net force, an object will accelerate less if it has a greater
The mature central nervous system contains precursor cells in the subventricular zone of the lateral ventricle. In this study we examined the possibility to affect fate of precursor cells through exogenous manipulations. The results indicate that administration of thyroid hormone and retinoic acid increases the expression of Ki67, a nuclear antigen associated with cell proliferation, and of nestin, a marker protein for precursor cells in the subventricular zone of adult male rats. Moreover, retinoic acid increases polysialated-neural cell adhesion molecules (PSA-NCAM)-immunoreactivity. These data suggest that nuclear receptor ligands are potential candidates for fate determination of precursor cells in the subventricular zone also in the adult brain.
Output: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
Police Story 2 (Chinese: , aka Jackie Chan's Police Story 2) is a 1988 Hong Kong action film written, directed by and starring Jackie Chan as Chan Ka-kui.
Output: Which was the country for Police Story 2?
Australia is the smallest continent in the world. It is a little smaller than China. It is on the Southern Hemisphere of the earth. Australia is big, but its population is small. The population of Australia is nearly as large as that of Shanghai. Enough laws have been made to fight against pollution. The cities in Australia have little air or water pollution. The sky is blue and the water is clean. You can clearly see fish in the rivers. Plants grow very well. Last month we visited Perth, the biggest city in Western Australia, and went to a wild flower _ . There we saw large numbers of wild flowers on show, most of which we had never seen before. We had a wonderful time. Perth is famous for its beautiful wild flowers. Every year in spring Perth has wild flower exhibitions. After visiting Perth, we spent a day in the countryside. We sat down and had a rest near a path at the foot of a hill. It was quiet and we enjoyed ourselves very much. When we heard bells ringing at the top of the hill, we looked up, but what we saw made us pick up all our things and run back to our car as quickly as we could. There were about three hundred sheep coming towards us along the path. Australia is famous for its sheep and kangaroos . After a short drive from any town, you will find yourself among the white sheep. Sheep, sheep, everywhere you can see sheep.
Output: Which country is the writer most possibly from?
Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes.
Output: Which protein does empagliflozin inhibit?
Stella Crawford is a fictional character from the BBC soap opera EastEnders, played by Sophie Thompson from 7 September 2006 to 23 July 2007.
Output: To which fictional work does Stella Crawford appear in?
The pathogenesis of restless legs syndrome (RLS) is unknown. Although iron deficiency anemia (IDA) is related with RLS, the mechanism of this relationship is still unknown. Therefore, we decided to examine some neurophysiological parameters that reflect the function of brainstem, spinal cord and peripheral nervous system. 34 patients diagnosed with IDA at the hematology department were questioned with a structured battery for RLS and additional symptoms. Of those, 14 patients had symptoms of RLS, while remaining 20 had no signs of this disorder. In both groups, electrophysiological examination including motor and sensory nerve conduction, F-responses, H-reflex, blink-reflex, and mixed nerve silent periods was performed. Neurological examination of all patients was normal. The two groups were identical for age and sex, and the difference between both groups concerning motor and sensory nerve conduction, F-wave, H-reflex, blink-reflex, and mixed nerve silent periods was insignificant. Results suggest that IDA does not cause electrophysiological changes in the peripheral nerves, spinal cord and brainstem, and therefore, measurement of these parameters in IDA patients does not seem effective for the confirmation of RLS.
Output: Which deficiency is the cause of restless leg syndrome?
Rampage Puzzle Attack is a puzzle game for Game Boy Advance, developed by Finnish development house Ninai Games and published by Midway Games.
Output: Who worked on Rampage Puzzle Attack?
Azeffoun is bounded by the Mediterranean Sea on the north, the town of Ait Chafaa on the east, and the common Akerrou, Aghrib in the south and Iflissen in the west.
Output: Which is the body of water by Azeffoun?