niryuu/sni-each-converted huggingface dataset:
Welcome to WeKnowDiets.com. We have compiled the most comprehensive database of information for people who are looking for a trimmer body and healthier lifestyle. There are now thousands of Weight-Loss Products and Diet Programs available to choose from-that can be a little confusing. Our goal is to give you a quick snapshot of what options are available to you. We will inform you of the hottest new ingredients and which products and programs bring you the most quality and best results. The most popular ones NuPhedrine-burn 500 more calories per day NuPhedrine is probably one of the best weight-loss pills ever made. What is so impressive about this pill is that the makers can honestly say that you WILL burn at least 500 more calories per day just by taking NuPhedrine. _ Miracle Fat Burning Cream Imagine being able to target your problem areas for rapid results. Now you can do just that. We have found that Miracle Fat Burning Cream is clinically proven to burn fat and it uses a patented delivery technology that works immediately. _ Alli Diet Pill This diet pill, claims to provide weight loss that "won't be easy". This product does not seem to promise particularly fast results, and instead emphasizes gradual weight loss. The accompanying book is intended to act as a companion to the weight-loss product. _ Bikini Boot Camp-14 days for a bikini body It is a customized back-to-basics system, which, regardless of its name, is actually about putting "fun" back into exercise while eating in a balanced way. The developers of this diet system make it accessible to everyone by bringing it into people's homes-in both a book and an online-based plan. _
Output: Which of the follwing is produced in the form of thick liquid?
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis.
Output: Which molecule is targeted by a monoclonal antibody Secukinumab?
We evaluated the new, fully automated molecular BD Max methicillin-resistant Staphylococcus aureus (MRSA) assay for detection of methicillin-resistant S. aureus in a low-prevalence (4.1%) setting. Sensitivity, specificity, and positive and negative predictive values were 93.9%, 99.2%, 83.8%, and 99.7%, respectively. The assay reported fewer unresolved results than the BD GeneOhm MRSA ACP assay.
Output: What is MRSA?
Malaria is one of the most devastating infectious diseases in the developing world. Until now, only one candidate malaria vaccine RTS,S/AS01 has shown modest protection in phase 3 trial in African infants. Hence the treatment of malaria still depends on the current chemotherapeutic drugs. Considering the resistance of malaria parasites to almost all used antimalarial drugs, aiming at multi-targets rather than a single target will be a more promising strategy. Previous studies have shown that myricetin and fisetin exhibited in vitro antimalarial activity against Plasmodium falciparum, but very little research focused on the molecular mechanism for their parasiticidal activity. The cysteine protease falcipain-2 and aspartic protease plasmepsin II have long been considered as important antimalarial drug targets, especially combined inhibition of these two proteases. In this study, we determined that myricetin and fisetin are dual inhibitors of falcipain-2 and plasmepsin II, which might account for their antimalarial properties. Overall, the dual inhibition of falcipain-2 and plasmepsin II by myricetin and fisetin has shed light on a possible mechanism for their antimalarial activity and provided a rationale for further development as antimalarial drugs.
Output: RTS S AS01 vaccine was developed to prevent which disease?
Jeanette Pohlen (born May 2, 1989) is an American professional basketball player for the Indiana Fever of the Women's National Basketball Association.
Output: What team does Jeanette Pohlen belong to?
Marjanovic took over Ciguli Miguli only after his proposal for Nikola Tesla, a biography of the famous engineer and inventor, had been rejected by Jadran Film.
Output: What production company was involved in Ciguli Miguli?
Monospitovo (Macedonian: ) is a village in the Bosilovo Municipality of Macedonia.
Output: Which country is Monospitovo located?
The Ehlers-Danlos syndrome is a heritable connective-tissue disorder caused by defects in fibrillar-collagen metabolism. Mutations in the type V collagen genes account for up to 50 percent of cases of classic Ehlers-Danlos syndrome, but many other cases are unexplained. We investigated whether the deficiency of the tenascins, extracellular-matrix proteins that are highly expressed in connective tissues, was associated with the Ehlers-Danlos syndrome. We screened serum samples from 151 patients with the classic, hypermobility, or vascular types of the Ehlers-Danlos syndrome; 75 patients with psoriasis; 93 patients with rheumatoid arthritis; and 21 healthy persons for the presence of tenascin-X and tenascin-C by enzyme-linked immunosorbent assay. We examined the expression of tenascins and type V collagen in skin by immunohistochemical methods and sequenced the tenascin-X gene. Tenascin-X was present in serum from all normal subjects, all patients with psoriasis, all patients with rheumatoid arthritis, and 146 of 151 patients with the Ehlers-Danlos syndrome. Tenascin-X was absent from the serum of the 5 remaining patients with Ehlers-Danlos syndrome, who were unrelated. Tenascin-X deficiency was confirmed in these patients by analysis of skin fibroblasts and by immunostaining of skin. The expression of tenascin-C and type V collagen was normal in these patients. All five of these patients had hypermobile joints, hyperelastic skin, and easy bruising, without atrophic scarring. Tenascin-X mutations were identified in all tenascin-X-deficient patients; one patient had a homozygous tenascin-X gene deletion, one was heterozygous for the deletion, and three others had homozygous truncating point mutations, confirming a causative role for tenascin-X and a recessive pattern of inheritance. Tenascin-X deficiency causes a clinically distinct, recessive form of the Ehlers-Danlos syndrome. This finding indicates that factors other than the collagens or collagen-processing enzymes can cause the syndrome and suggests a central role for tenascin-X in maintaining the integrity of collagenous matrix.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
Teenage Catgirls in Heat (originally titled Catgirls) is a 1993 comedy film co-written and directed by Scott Perry and distributed by Troma Entertainment.
Output: What studio produced Teenage Catgirls in Heat?
Chediak-Higashi syndrome (CHS) is a rare autosomal recessive disorder in which an immune deficiency occurs in association with pigmentation abnormalities. Most patients who do not undergo bone marrow transplantation die of a lymphoproliferative syndrome, though some patients with CHS have a relatively milder clinical course of the disease. The large size of the LYST gene, defective in CHS, has made it difficult to screen for mutations in a large number of patients. Only 8 mutations have been identified so far, and all lead to a truncated LYST protein. We conducted protein truncation tests on this gene in 8 patients with CHS. Different LYST mutations were identified in all subjects through this approach, strengthening the observation of a high frequency of truncated LYST proteins as the genetic cause of CHS.
Output: Which syndrome is associated with mutations in the LYST gene?
Polyglutamine diseases, including Huntington's disease, designate a group of nine neurodegenerative disorders characterized by the presence of a toxic polyglutamine expansion in specific target proteins. Using cell and mouse models, we have shown that expanded polyglutamine led to activation of the stress kinase JNK and the transcription factor AP-1, which are implicated in neuronal death. Polyglutamine expansion-induced stress shared common features with protein-damaging stress such as heat shock, because activation of JNK involved inhibition of JNK phosphatase activities. Indeed, expanded polyglutamine impaired the solubility of the dual-specificity JNK phosphatase M3/6. Aggregation of M3/6 by polyglutamine expansion appeared to be indirect, because M3/6 was not recruited into polyglutamine inclusions. The heat shock protein HSP70, which is known to inhibit JNK during the heat shock response, suppressed polyglutamine-mediated aggregation of M3/6 and activation of JNK. Interestingly, levels of HSP70 were down-regulated by polyglutamine expansion. We suggest that reduction of HSP70 by expanded polyglutamine is implicated in aggregation and inhibition of M3/6 and in activation of JNK and AP-1.
Output: Which protein is affected by dusp8 activation?
City Reign are an indie rock band from Manchester, England.
Output: From what city is the band City Reign?
The Jaguar XJ is the name of a series of flagship, full-size, luxury cars sold by the British automobile brand, Jaguar Cars.
Output: Which company is known as the manufacturer of Jaguar XJ?
JSC NMZ or Nizhny Novgorod Machine-building Plant (Russian: or All-Union Machine-building Plant New Sormovo Russian: '' '', Joseph Stalin Factory No. 92, Zavod imeni Stalina, or ZiS) was a Soviet artillery factory in the Sormovo district of Gorky.
Output: What is the city where NMZ is from?
Spinocerebellar ataxia type 3 is a neurodegenerative disorder caused by the expansion of the polyglutamine repeat region within the ataxin-3 protein. The mutant protein forms intracellular aggregates in the brain. However, the cellular mechanisms causing toxicity are still poorly understood and there are currently no effective treatments. In this study we show that administration of a rapamycin ester (cell cycle inhibitor-779, temsirolimus) improves motor performance in a transgenic mouse model of spinocerebellar ataxia type 3. Temsirolimus inhibits mammalian target of rapamycin and hence upregulates protein degradation by autophagy. Temsirolimus reduces the number of aggregates seen in the brains of transgenic mice and decreases levels of cytosolic soluble mutant ataxin-3, while endogenous wild-type protein levels remain unaffected. Temsirolimus is designed for long-term use in patients and therefore represents a possible therapeutic strategy for the treatment of spinocerebellar ataxia type 3. Using this disease model and treatment paradigm, we employed a microarray approach to investigate transcriptional changes that might be important in the pathogenesis of spinocerebellar ataxia type 3. This identified ubiquitin specific peptidase-15, which showed expression changes at both the messenger ribonucleic acid and protein level. Ubiquitin specific peptidase-15 levels were also changed in mice expressing another mutant polyglutamine protein, huntingtin. In total we identified 16 transcripts that were decreased in transgenic ataxin-3 mice that were normalized following temsirolimus treatment. In this mouse model with relatively mild disease progression, the number of transcripts changed was low and the magnitude of these changes was small. However, the importance of these transcriptional alterations in the pathogenesis of spinocerebellar ataxia type 3 remains unclear.
Output: Which is the protein implicated in Spinocerebellar ataxia type 3?
NGC 65 (ESO 473-10A/PGC 1229) is a galaxy in the constellation Cetus.
Output: What is the constellation that is made with NGC 65?
Puyi's last surviving younger half-brother Puren (b. 1918) has adopted the Chinese name Jin Youzhi and lived in China until his death in 2015.
Output: What is Puyi's brothers name?
The muscular system consists of all the muscles in the body. This is the body system that allows us to move. You also depend on many muscles to keep you alive. Your heart, which is mostly muscle, pumps blood around your body. Each muscle in the body is made up of cells called muscle fibers. Muscle fibers are long, thin cells that can do something that other cells cannot dothey are able to get shorter. Shortening of muscle fibers is called contraction. Muscle fibers can contract because they are made of proteins, called actin and myosin, that form long filaments (or fibers). When muscles contract, these protein filaments slide or glide past one another, shortening the length of the cell. When your muscles relax, the length extends back to the previous position. Nearly all movement in the body is the result of muscle contraction. You can control some muscle movements. However, certain muscle movements happen without you thinking about them. Muscles that are under your conscious control are called voluntary muscles. Muscles that are not under your conscious control are called involuntary muscles. Muscle tissue is one of the four types of tissue found in animals. There are three different types of muscle in the body ( Figure 1.1): 1. Skeletal muscle is made up of voluntary muscles, usually attached to the skeleton. Skeletal muscles move the body. They can also contract involuntarily by reflexes. For example, you can choose to move your arm, but your arm would move automatically if you were to burn your finger on a stove top. This voluntary contraction begins with a thought process. A signal from your brain tells your muscles to contract or relax. Quickly contract and relax the muscles in your fingers a few times. Think about how quickly these signals must travel throughout your body to make this happen. 2. Smooth muscle is composed of involuntary muscles found within the walls of organs and structures such as the esophagus, stomach, intestines, and blood vessels. These muscles push materials like food or blood through organs. Unlike skeletal muscle, smooth muscle can never be under your control. 3. Cardiac muscle is also an involuntary muscle, found only in the heart. The cardiac muscle fibers all contract together, generating enough force to push blood throughout the body. What would happen if this muscle was under conscious or voluntary control? There are three types of muscles in the body: cardiac, skeletal, and smooth.
Output: what muscle is found only in one place in the body?
An old man was fishing by a river. A child was watching him. The old man was really good at fishing and it didn't take him much time to catch a basket of fish. The old man saw that the child was very cute, and he wanted to give her a whole basket of fish. But the child shook her head. The old man was surprised and asked "Why don't you want the fish?" The child replied,"I want the fishing rod in your hands." The old man asked, "Why do you want the rod?" "It won't take long to eat all the fish in the basket. But if I have the fishing rod, I can go fishing by myself and I won't be afraid of not having any fish to eat." I think you will certainly say that the girl is very smart. Wrong! If she doesn't know how to fish, she cannot have fish to eat, even though she has the fishing rod. It's useless to only have a fishing rod. Fishing skills are the most important, not the fishing rod. Too many people think that if they have a "fishing rod" in their life, they will no longer fear the difficulties in life. They are just like the child, who thought that if she had a fishing rod, she would have fish to eat.
Output: Where did the old man put the fish?
To evaluate the effects of the sodium glucose cotransporter 2 (SGLT2) inhibitor empagliflozin added to metformin for 12weeks in patients with type 2 diabetes. This dose-ranging, double-blind, placebo-controlled trial randomized 495 participants with type 2 diabetes inadequately controlled on metformin [haemoglobin A1c (HbA1c) >7 to 10%] to receive 1, 5, 10, 25, or 50mg empagliflozin once daily (QD), or placebo, or open-label sitagliptin (100mg QD), added to metformin for 12weeks. The primary endpoint was change in HbA1c from baseline to week 12 (empagliflozin groups versus placebo). Reductions in HbA1c of -0.09 to -0.56% were observed with empagliflozin after 12weeks, versus an increase of 0.15% with placebo (baseline: 7.8-8.1%). Compared with placebo, empagliflozin doses from 5 to 50mg resulted in reductions in fasting plasma glucose (-2 to -28mg/dl vs. 5mg/dl with placebo; p<0.0001) and body weight (-2.3 to -2.9kg vs. -1.2kg; p<0.01). Frequency of adverse events was generally similar with empagliflozin (29.6-48.6%), placebo (36.6%) and sitagliptin (35.2%). Hypoglycaemia rates were very low and balanced among groups. Most frequent adverse events with empagliflozin were urinary tract infections (4.0% vs. 2.8% with placebo) and pollakiuria (2.5% vs. 1.4% with placebo). Genital infections were reported only with empagliflozin (4.0%). Once daily empagliflozin as add-on therapy to metformin was well tolerated except for increased genital infections and resulted in reductions in HbA1c, fasting plasma glucose and body weight in patients with type 2 diabetes inadequately controlled on metformin monotherapy.
Output: Which protein does empagliflozin inhibit?
In a chemical formula, the elements in a compound are represented by their chemical symbols, and the ratio of different elements is represented by subscripts. Consider the compound water as an example. Each water molecule contains two hydrogen atoms and one oxygen atom. Therefore, the chemical formula for water is: H2 O The subscript 2 after the H shows that there are two atoms of hydrogen in the molecule. The O for oxygen has no subscript. When there is just one atom of an element in a molecule, no subscript is used in the chemical formula. The Table 1.1 shows four examples of compounds and their chemical formulas. The first two compounds are ionic compounds, and the second two are covalent compounds. Each formula shows the ratio of ions or atoms that make up the compound. Name of Compound Type of Compound Sodium chloride ionic Calcium iodide ionic Hydrogen peroxide covalent Carbon dioxide covalent Ratio of Ions or Atoms of Each Element 1 sodium ion (Na+ ) 1 chloride ion (Cl ) 1 calcium ion (Ca2+ ) 2 io- dide ions (I ) 2 hydrogen atoms (H) 2 oxygen atoms (O) 1 carbon atom (C) 2 oxy- gen atoms (O) Chemical Formulas NaCl CaI2 H2 O2 CO2 There is a different rule for writing the chemical formula for each type of compound. Ionic compounds are compounds in which positive metal ions and negative nonmetal ions are joined by ionic bonds. In these compounds, the chemical symbol for the positive metal ion is written first, followed by the symbol for the negative nonmetal ion. Click image to the left or use the URL below. URL: Q: The ionic compound lithium fluoride consists of a ratio of one lithium ion (Li+ ) to one fluoride ion (F ). What is the chemical formula for this compound? A: The chemical formula is LiF. Covalent compounds are compounds in which nonmetals are joined by covalent bonds. In these compounds, the element that is farther to the left in the periodic table is written first, followed by the element that is farther to the right. If both elements are in the same group of the periodic table, the one with the higher period number is written first. Click image to the left or use the URL below. URL: Q: A molecule of the covalent compound nitrogen dioxide consists of one nitrogen atom (N) and two oxygen atoms (O). What is the chemical formula for this compound? A: The chemical formula is NO2 .
Output: correct rules for writing the chemical formulas of covalent compounds include which of the following?
Random Hearts is a 1999 American romantic drama film directed by Sydney Pollack and starring Harrison Ford and Kristin Scott Thomas.
Output: The director of Random Hearts is who?
People from all over the world visit Disneyland to have fun, not to get sick. But last week, an outbreak of measles spread from the Southern California theme park. As of Monday, January 19, at least 52 people have got the easily spread illness. The majority of the reported cases of measles are from people who visited the park before. According to the California Department of Public Health, these people were exposed to the illness at Disneyland from December 17-20. Officials believe the cause is likely someone who caught measles abroad and visited Disneyland, but this has yet to be proved. However, in 2014, California had its highest measles infection rate in nearly twenty years. There were 66 cases of measles reported in the state--23 of them in Orange County, where Disneyland is located. Measles spreads very easily. It can be caught from coughing and sneezing. Crowded areas like theme parks are especially suitable for its spread. The illness starts with a fever and develops into symptoms including a cough, runny nose, red eyes and so on. About three out of ten people infected with measles will develop another health problem, including an ear infection or pneumonia . The best way to _ measles is to get vaccinated . An unvaccinated person is 35 times more likely to catch measles than someone who received a vaccination.
Output: How many people suffered from measles in California in 2014?
How men first learnt to invent words is unknown; in other words, the origin of language is a mystery. All we really know is that men, unlike animals, somehow invented certain sounds to express thoughts and feelings, actions and things, so that they could communicate with each other; and that later they agreed upon certain signs, called letters. These letters could be combined to represent those sounds, and which could be written down. Those sounds, whether spoken, or written in letters, we call words. The power of words, then, lies in their associations---the things they bring up before our minds. Words become filled with meaning for us by experience, and the longer we live, the more certain words recall to us the glad and sad events of our past; and the more we read and learn, the more the number of words that mean something to us increases. Great writers are those who not only have great thoughts but also express these thoughts in words which appeal powerfully to our minds and emotions. This charming and telling use of words is what we call literary style. Above all, the real poet is a master of words. He can convey his meaning in words which sing like music and which by their position and association can move men to tears. We should therefore learn to choose our words carefully and use them accurately, or they will make our speech silly and vulgar .
Output: What does this passage primarily concern?
To evaluate the impact of a more limited paraurethral dissection, avoidance of perforating the obturator membrane with scissors or guide, and a more medial trajectory of the trocar in positioning the TVT-O device on stress urinary incontinence cure rates. One hundred and ten patients were recruited for this randomized, single blind, multicenter, non-inferiority study, with a 1:1 ratio to undergo the traditional (n=55) or the modified (n=55) technique. Preoperatively, patients underwent POP-Q staging, Q-tip test, challenge stress test and urodynamics, and completed the I-QoL, PISQ-12, and PGI-S questionnaires. During the post-operative period, patients attributed a pain VAS score 1, 3, 6, 12 and 24h after the procedure and were followed up at 12 months, undergoing the same baseline evaluations. The primary outcome was the cure rate (absence of urine leaks at the challenge stress test or urodynamic testing) one year after the procedure. The primary outcome was evaluated using a non-inferiority test. No differences were observed in cure rates (traditional technique 92.3% vs. modified technique 88.8% and non-inferiority P<0.05) and in questionnaire scores between the two groups. Post-operative pain was significantly lower in the modified technique group at each time point assessed, with the exception of 12h post-operatively. No differences between the two groups were observed in the number of analgesic vials administered. The modified technique does not seem to reduce the efficacy of TVT-O, but induces a reduction of post-operative pain.
Output: Which type of urinary incontinence is diagnosed with the Q tip test?
We report the case of a Japanese boy whose dysmorphic features were consistent with those of Shprintzen-Goldberg syndrome. The radiological features were characterized by late-onset craniosynostosis, arachnodactyly, undermodeling of short tubular bones, mildly undermodeled and slightly bowed long bones, twisted ribs and tall vertebral bodies with elongated neural arches. Apart from the craniosynostosis, these skeletal changes resembled those of frontometaphyseal dysplasia, a well-known craniotubular dysplasia. Shprintzen-Goldberg syndrome also shares many clinical features with frontometaphyseal dysplasia.
Output: Which disease is included as an additional feature in the Goldberg-Shprintzen syndrome?
The influence of America is increasing in my country. Spanish people drink Coca Cola, wear blue jeans, watch Hollywood movies, listen to American music, and eat fast food, and they do these things every day. I think that American movies are a good way to spread American culture because people are often influenced by what they see in the movies. Most of the programs and documentaries we watch on TV are from America, and most of the movies we go to see are made in Hollywood. In the last few years, the government has tried to protect the Spanish movies. Now, in our cinemas, at least twenty percent of the movies which are shown must be from Spain or from other countries in Europe. American culture is a part of Spanish life now. It's certain that many things from America are as much a part of people's lives as Spanish things. For example, Coca Cola is as familiar to everybody as any typical Spanish product. I've known about Coca Cola for my whole life. However, it's different with Western fast food. For example, I don't think McDonald's is as successful in Spain as it is in other countries. In my opinion, one of the reasons may be the lifestyle of the Spanish people. The Spanish people normally eat at home. On the other hand, maybe McDonald's hamburgers will eventually replace the famous Spanish tapas. It's true that in every city in Spain you can find a McDonald's, and it is more popular among the Spanish children than among the adults. In any case, it's obvious that American culture is becoming more and more a part of our lives every day.
Output: What plays an important part in the spreading of American culture in Spain?
The End Is Nigh was an annual British fanzine edited by Michael Molcher.
Output: Who founded The End Is Nigh?
In mathematics, the Weil conjectures were some highly influential proposals by Andre Weil (1949) on the generating functions (known as local zeta-functions) derived from counting the number of points on algebraic varieties over finite fields.
Output: Who is the Weil conjectures named after?
Alice's Day at Sea is an animated short film that is part of the Alice Comedies that were released by The Walt Disney Company in 1924.
Output: What production company was involved in Alice's Day at Sea?
Marquis Xuan of Cai () (? - 715 BC), born Ji Cuofu (), was the eleventh ruler of the State of Cai from 750 BC to 715 BC. He was the only known son of Marquis Dai of Cai (), his predecessor.
Output: Who fathered Marquis Xuan of Cai?
The little girl pictured below ( Figure 1.1) has a scraped knee. A scrape is a break in the skin that may let pathogens enter the body. If bacteria enter through the scrape, they could cause an infection. These bacteria would then face the bodys second line of defense. The second line of defense is also nonspecific, fighting many types of pathogens. The bodys second line of defense against pathogens includes the inflammatory response. If bacteria enter the skin through a scrape, the area may become red, warm, and painful. These are signs of inflammation. Inflammation is one way the body reacts to infections or injuries. Inflammation is caused by chemicals that are released when skin or other tissues are damaged. The chemicals cause nearby blood vessels to dilate, or expand. This increases blood flow to the damaged area, which makes the area red and slightly warm. The chemicals also attract white blood cells called neutrophils to the wound and cause them to leak out of blood vessels into the damaged tissue. This little girl just got her first scraped knee. It doesnt seem to hurt, but the break in her skin could let pathogens enter her body. Thats why scrapes should be kept clean and protected until they heal. What do these white blood cells do at the site of inflammation? The main role of white blood cells is to fight pathogens in the body. There are actually several different kinds of white blood cells. Some white blood cells have very specific functions. They attack only certain pathogens. Other white blood cells attack any pathogen they find. These white blood cells travel to areas of the body that are inflamed. They are called phagocytes, which means eating cells. Neutrophils are a type of phagocyte. In addition to pathogens, phagocytes eat dead cells. They surround the pathogens and destroy them. Sometimes it is said that the phagocyte engulfs the pathogen, and then destroys it. This process is called phagocytosis. White blood cells also make chemicals that cause a fever. A fever is a higher-than-normal body temperature. Normal human body temperature is 98.6 F (37 C). Most bacteria and viruses that infect people reproduce fastest at this temperature. When the temperature is higher, the pathogens cannot reproduce as fast, so the body raises the temperature to kill them. A fever also causes the immune system to make more white blood cells. In these ways, a fever helps the body fight infection.
Output: the dilation of blood vessels during the inflammatory response
Following the assassination of her nephew Ptolemy XI Alexander II (80 BC), Cleopatra Selene I remained the only legitimate surviving member of the Ptolemaic dynasty.
Output: What was the noble family that Cleopatra Selene I was from?
Coal, a solid fossil fuel formed from the partially decomposed remains of ancient forests, is burned primarily to produce electricity. Coal use is undergoing enormous growth as the availability of oil and natural gas decreases and cost increases. This increase in coal use is happening particularly in developing nations, such as China, where coal is cheap and plentiful. Coal is black or brownish-black. The most common form of coal is bituminous, a sedimentary rock that contains impurities such as sulfur (Figure 1.1). Anthracite coal has been metamorphosed and is nearly all carbon. For this reason, anthracite coal burns more cleanly than bituminous coal. Coal forms from dead plants that settled at the bottom of ancient swamps. Lush coal swamps were common in the tropics during the Carboniferous period, which took place more than 300 million years ago (Figure 1.2). The climate was warmer then. Mud and other dead plants buried the organic material in the swamp, and burial kept oxygen away. When plants are buried without oxygen, the organic material can be preserved or fossilized. Sand and clay settling on top of the decaying plants squeezed out the water and other substances. Millions of years later, what remains is a carbon- containing rock that we know as coal. Around the world, coal is the largest source of energy for electricity. The United States is rich in coal (Figure 1.3). California once had a number of small coal mines, but the state no longer produces coal. To turn coal into electricity, the rock is crushed into powder, which is then burned in a furnace that has a boiler. Like other fuels, coal releases its energy as heat when it burns. Heat from the burning coal boils the water in the boiler to make steam. The steam spins turbines, which turn generators to create electricity. In this way, the energy stored in the coal is converted to useful energy like electricity. For coal to be used as an energy source, it must first be mined. Coal mining occurs at the surface or underground by methods that are described in the the chapter Materials of Earths Crust (Figure 1.4). Mining, especially underground The location of the continents during the Carboniferous period. Notice that quite a lot of land area is in the region of the tropics. mining, can be dangerous. In April 2010, 29 miners were killed at a West Virginia coal mine when gas that had accumulated in the mine tunnels exploded and started a fire. Coal mining exposes minerals and rocks from underground to air and water at the surface. Many of these minerals contain the element sulfur, which mixes with air and water to make sulfuric acid, a highly corrosive chemical. If the sulfuric acid gets into streams, it can kill fish, plants, and animals that live in or near the water. Click image to the left or use the URL below. URL:
Output: coal mining exposes this element, which when mixed with air and water makes a highly corrosive chemical.
So what happens to your bodys wastes? Obviously, you must get rid of them. This is the job of the excretory system. You remove waste as a gas (carbon dioxide), as a liquid (urine and sweat), and as a solid. Excretion is the process of removing wastes and excess water from the body. Recall that carbon dioxide travels through the blood and is transferred to the lungs where it is exhaled. In the large intestine, the remains of food are turned into solid waste for excretion. How is waste other than carbon dioxide removed from the blood? That is the role of the kidneys. Urine is a liquid waste formed by the kidneys as they filter the blood. If you are getting plenty of fluids, your urine should be almost clear. But you might have noticed that sometimes your urine is darker than usual. Do you know why this happens? Sometimes your body is low on water and trying to reduce the amount of water lost in urine. Therefore, your urine gets darker than usual. Your body is striving to maintain homeostasis through the process of excretion. Urine helps remove excess water, salts, and nitrogen from your body. Your body also needs to remove the wastes that build up from cell activity and from digestion. If these wastes are not removed, your cells can stop working, and you can get very sick. The organs of your excretory system help to release wastes from the body. The organs of the excretory system are also parts of other organ systems. For example, your lungs are part of the respiratory system. Your lungs remove carbon dioxide from your body, so they are also part of the excretory system. More organs of the excretory system are listed below ( Table 1.1). Organ(s) Function Lungs Skin Remove carbon dioxide. Sweat glands remove water, salts, and other wastes. Removes solid waste and some wa- ter in the form of feces. Remove urea, salts, and excess wa- ter from the blood. Large intestine Kidneys Component of Other Organ Sys- tem Respiratory system Integumentary system Digestive system Urinary system
Output: what organ of the excretory system removes solid waste?
Who's Got Trouble? is an album by Shivaree, released by Zoe Records in 2005.
Output: What label was responsible for Who's Got Trouble??
To provide for the Hall of Mirrors as well as the salon de la guerre and the salon de la paix, which connect the grand appartement du roi with the grand appartement de la reine, architect Jules Hardouin Mansart appropriated three rooms from each apartment as well as the terrace that separated the two apartments.
Output: Who was the architect or designer of Hall of Mirrors?
Marco Roelofsen (born October 3, 1968 in Harderwijk, Gelderland) is a retired football (soccer) midfielder from the Netherlands, who started his professional career in the 1987/1988 season.
Output: In which country did Marco Roelofsen live?
In plant, primary transcripts (pri-miRNAs) transcribed from miRNA genes by RNA polymerase II are first processed into stem-loop pre-miRNAs and further chopped into 21nt long miRNAs by RNase III-like enzyme DCL1. SERRATE (SE) protein is an essential component for miRNA processing by assisting DCL1 for accurate cleavage. Here we report the crystal structure of Arabidopsis SE core (residues 194-543) at 2.7A. SE core adopts the 'walking man-like' topology with N-terminal helices, C-terminal non-canonical zinc-finger domain and novel Middle domain resembling the leading leg, the lagging leg and the body, respectively. Pull-down assay shows that SE core provides the platform for HYL1 and DCL1 binding, whereas in vitro RNA binding and in vivo mutant rescue experiments suggest that the non-canonical zinc-finger domain coupled with C-terminal tail binds miRNA precursors. SE presumably works as a scaffold-like protein capable of binding both protein and RNA to guide the positioning of miRNA precursor toward DCL1 catalytic site within miRNA processing machinery in plant.
Output: Which polymerase transcribes pri-miRNAs?
The Slovak National Uprising (Slovak: Slovenske narodne povstanie, abbreviated SNP) or 1944 Uprising was an armed insurrection organized by the Slovak resistance movement during World War II. It was launched on 29 August 1944 from Banska Bystrica in an attempt to resist German troops that had occupied Slovak territory and to overthrow the collaborationist government of Jozef Tiso.
Output: What year did Slovak National Uprising start?
The Sumatran serow is threatened due to habitat loss and hunting, leading to it being evaluated as vulnerable by the IUCN.
Output: What status on the endangered list is Sumatran serow?
Weisse Wiese (The White Field), also known as Borussia Sportpark, was the first home stadium of Borussia Dortmund.
Output: What team uses Weisse Wiese?
One of the most recent social changes taking place in the world is social networking. Social networking has been in existence for at least 150 years, and probably longer than that. In the times before the invention of the computer and the World Wide Web (WWW), social networking was done in person. People who had similar likes and interests would gather together to share experiences, make new friends, and improve their businesses. On the Internet, social networking websites made their first appearances during the late 1990s. The first major social networking website in the United States was MySpace. MySpace allowed its users to exchange messages, share pictures, and make new friends in a way that was never thought of in the past. With MySpace, people who did not go out much could reach out to others from their own homes. In 2004, Facebook was created. It was first a website created for use by Harvard University's students and teachers, but it soon expanded to include just about everyone. It is now larger than some of the largest companies in the world. It is a website that is changing all the time. Facebook has completely changed the way people stay connected with each other and the rest of the world. The way it works is simple. Users can set up a new account easily. All a new user needs is an email address to start. Once a person has created an account and his friend also has his own Facebook page, he can invite his friend by sending a request out to him. Once you get started, making new friends will come easily.
Output: What do new users of Facebook need to create an account?
Franklin MacVeagh died in Chicago, Illinois, on July 6, 1934, at age 96, and was interred in Graceland Cemetery in Chicago, Illinois.
Output: The final resting place of Franklin MacVeagh is at what cemetery?
Water pollution contributes to water shortages by making some water sources unavailable for use. In underdeveloped countries, raw sewage is dumped into the same water that people drink and bathe in. Even in developed countries, water pollution affects human and environmental health. Water pollution includes any contaminant that gets into lakes, streams, and oceans. The most widespread source of water contamination in developing countries is raw sewage. In developed countries, the three main sources of water pollution are described below. Wastewater from cities and towns contains many different contaminants from many different homes, businesses, and industries (Figure 1.1). Contaminants come from: Sewage disposal (some sewage is inadequately treated or untreated). Storm drains. Septic tanks (sewage from homes). Boats that dump sewage. Yard runoff (fertilizer and herbicide waste). Large numbers of sewage spills into San Francisco Bay are forcing cities, water agencies and the public to take a closer look at wastewater and its impacts on the health of the bay. QUEST investigates the causes of the spills and whats being done to prevent them. Click image to the left or use the URL below. URL: Factories and hospitals spew pollutants into the air and waterways (Figure 1.2). Some of the most hazardous industrial pollutants include: Radioactive substances from nuclear power plants and medical and scientific sources. Heavy metals, organic toxins, oils, and solids in industrial waste. Chemicals, such as sulfur, from burning fossil fuels. Oil and other petroleum products from supertanker spills and offshore drilling accidents. Heated water from industrial processes, such as power stations. Runoff from crops, livestock, and poultry farming carries contaminants such as fertilizers, pesticides, and animal waste into nearby waterways (Figure 1.3). Soil and silt also run off farms. Animal wastes may carry harmful diseases, particularly in the developing world. The high density of animals in a factory farm means that runoff from the area is full of pollutants. Fertilizers that run off of lawns and farm fields are extremely harmful to the environment. Nutrients, such as nitrates, in the fertilizer promote algae growth in the water they flow into. With the excess nutrients, lakes, rivers, and bays become clogged with algae and aquatic plants. Eventually these organisms die and decompose. Decomposition uses up all the dissolved oxygen in the water. Without oxygen, large numbers of plants, fish, and bottom-dwelling animals die.
Output: contaminants such as radioactive substances, toxic chemicals and petroleum come from __________.
King of the Ants is a 2003 American revenge film directed by Stuart Gordon, written by Charlie Higson, and starring Chris McKenna.
Output: Who was the main director of King of the Ants?
The Gruffalo is a children's book by writer and playwright Julia Donaldson, illustrated by Axel Scheffler, that tells the story of a mouse, the protagonist of the book, taking a walk in a European forest.
Output: What person illustrated The Gruffalo?
Advance and Be Mechanized, released in 1967, was the penultimate Tom and Jerry cartoon.
Output: What series is Advance and Be Mechanized in?
The first year after birth is called infancy. Infancy is a period when the baby grows very fast. During infancy, the baby doubles in length and triples in weight. Other important changes also happen during infancy: The babys teeth start to come in, usually at about six months of age ( Figure 1.1). The baby starts smiling, paying attention to other people, and grabbing toys. The baby begins making babbling sounds. By the end of the first year, the baby is starting to say a few words, such as mama and dada. The baby learns to sit, crawl, and stand. By the end of the first year, the baby may be starting to walk. Childhood begins after the babys first birthday and continues until the teen years. Between one and three years of age, a child is called a toddler. During the toddler stage, growth is still fast, but not as fast as it was during infancy. A toddler learns many new words. The child even starts putting together words in simple sentences. Motor skills also develop quickly during this stage. By age three, most children can run and climb steps. They can hold crayons and scribble with them. They can also feed themselves and use the toilet. From age three until the teens, growth is slower. The body also changes shape. The arms and legs get longer compared to the trunk. Children continue to develop new motor skills. For example, many young children learn how to ride a tricycle and then a bicycle. Most also learn how to play games and sports ( Figure 1.2). By age six, children start losing their baby teeth. Their permanent teeth begin coming in to replace them. They also start school and learn how to read and write. They develop friendships and become less dependent on their parents. There are numerous milestones that occur during the first few years of childhood. These include the use of language, walking and running, understanding simple concepts, pretend play, the development of fine motor skills, the development of independence, Children develop better motor skills as they get older. having temper tantrums, demonstrating separation anxiety, becoming fully potty-trained, showing natural curiosity.
Output: during infancy, a baby
King Hedley II is a play by American playwright August Wilson, the eighth in his ten-part series, The Pittsburgh Cycle.
Output: Who wrote the novel King Hedley II?
Following a third revolt with the proclamation of Mirza Muhammad Hakim, Akbar's brother and the Mughal ruler of Kabul, as emperor, his patience was finally exhausted.
Output: What is Akbar's brothers name?
A blinded, retrospective study was performed to determine the value of supine abdominal radiographs in diagnosing pneumoperitoneum. Supine films from 44 cases of pneumoperitoneum were randomly interspersed among supine films from 87 control subjects without free air, and the films were reviewed for the presence or absence of various signs of pneumoperitoneum, including Rigler's sign (gas on both sides of the bowel wall), the falciform ligament sign (gas outlining the falciform ligament), the football sign (gas outlining the peritoneal cavity), the inverted-V sign (gas outlining the medial umbilical folds), and the right-upper-quadrant gas sign (localized gas in the right upper quadrant). One or more of these signs were present in 26 cases (59%) of pneumoperitoneum, including the right-upper-quadrant gas sign in 18 cases (41%), Rigler's sign in 14 cases (32%), and the falciform ligament and football signs in one case each (2%). Unfortunately, there were frequent errors in the interpretation of the right-upper-quadrant gas sign and Rigler's sign, with a total of 11 false-positive cases (13%). Further analysis of the true-positive right-upper-quadrant gas signs showed that these gas collections were always triangular or linear with an inferolateral to superomedial orientation and, if triangular, a concave superolateral border. In the true-positive Rigler's signs, the bowel wall thickness ranged from 1 to 8 mm, whereas the false positives all had a bowel wall thickness of 1 mm or less. Proper interpretation of the various signs of pneumoperitoneum on supine films should lead to more accurate diagnosis of this condition.
Output: Falciform ligament sign is characteristic to which disease?