niryuu/sni-each-converted huggingface dataset:
Marjorie Bruce or Marjorie de Brus (1296/7 -- 2 March 1316) was the eldest daughter of Robert the Bruce, King of Scots by his first wife, Isabella of Mar, and the founder of the Stewart dynasty.
Output: Which lady Marjorie Bruce was born to?
The Quai Saint-Michel and Notre-Dame is a 1901 oil on canvas painting by the French artist Maximilien Luce.
Output: What material was used for The Quai Saint-Michel and Notre-Dame?
The China Davis Cup team represents the People's Republic of China in Davis Cup tennis competition and are governed by the Chinese Tennis Association.
Output: Which sport has connection with China Davis Cup team?
The 2010 United States Census reported that Marin County had a population of 252,409. The racial makeup of Marin County was 201,963 (80.0%) White (U.S. Census), 6,987 (2.8%) African American (U.S. Census), 1,523 (0.6%) Native American (U.S. Census), 13,761 (5.5%) Asian (U.S. Census), 509 (0.2%) Pacific Islander (U.S. Census), 16,973 (6.7%) from Race (United States Census), and 10,693 (4.2%) from two or more races. Hispanic (U.S. Census) or Latino (U.S. Census) of any race were 39,069 persons (15.5%).
Output: Which group from the census is smaller: Asian or African American?
Isias was the daughter of King Ariobarzanes I of Cappadocia and his wife Queen Athenais Philostorgos I, while her brother was King Ariobarzanes II of Cappadocia.
Output: Who was the brother of Isias?
In late July, Danzig was re-inforced by a Dutch garrison, and a combined Danish and Dutch fleet broke the naval blockage imposed on Danzig by Charles X Gustav. On 28-30 July, a combined Brandenburgian-Swedish army was able to defeat the Polish-Lithuanian army in the Battle of Warsaw, forcing John II Casimir to retreat to Lublin. In August, Alexis' army took Livonian Kokenhausen , laid siege to Riga and Dorpat and raided Estonia, Ingria and Kexholm. On 4 October, John II Casimir stormed eczyca in Greater Poland before heading for Royal Prussia, and on 8 October, Wincenty Korwin Gosiewski with 12,000 to 13,000 Lithuanian and Crimean Tartar cavalry overran a Brandenburgian-Swedish force in the Battle of Prostken in Ducal Prussia. Gosiewski then ravaged Ducal Prussia, burning 13 towns and 250 villages, in a campaign that entered folklore because of the high death toll and the high number of captives deported to the Crimea. On 22 October, Gosiewski was defeated by Swedish forces in the Battle of Filipow and turned to Lithuania. Also on 22 October, besieged Dorpat surrendered to Alexis, while the Russian siege of Swedish-held Riga was lifted. John II Casimir meanwhile took Bromberg and Konitz in Royal Prussia, and from 15 November 1656 until February 1657 stayed in Danzig, where a Swedish siege had to be lifted due to Dutch intervention, just 55 kilometers away from Charles X Gustav's quarters in Elbing.
Output: Gosiewski ravaged Ducal Prussia for what reason?
Mapfanga is a settlement in Kenya's Coast Province.
Output: Which country is Mapfanga located?
The 80-string koto (or hachijugen) was an invention of Japanese composer Michio Miyagi which appeared In 1923.
Output: By whom was 80-string koto discovered?
Mustafabyli (also Mustafabeyli) is a village in the Saatly Rayon of Azerbaijan.
Output: What is the country that Mustafabəyli is located in?
The rate at which a device changes electric current to another form of energy is called electric power. The SI unit for powerincluding electric poweris the watt. A watt equals 1 joule of energy per second. High wattages are often expressed in kilowatts, where 1 kilowatt equals 1000 watts. The power of an electric device, such as a hair dryer, can be calculated if you know the voltage of the circuit and how much current the device receives. The following equation is used: Power (watts) = Current (amps) Voltage (volts) Assume that Mirandas hair dryer is the only electric device in a 120-volt circuit that carries 15 amps of current. Then the power of her hair dryer in kilowatts is: Power = 15 amps 120 volts = 1800 watts, or 1.8 kilowatts Q: If a different hair dryer is plugged into a 120-volt circuit that carries 10 amps of current. What is the power of the other hair dryer? A: Substitute these values in the power equation: Power = 10 amps 120 volts = 1200 watts, or 1.2 kilowatts Did you ever wonder how much electrical energy it takes to use an appliance such as a hair dryer? Electrical energy use depends on the power of the appliance and how long it is used. It can be calculated with this equation: Electrical Energy = Power Time If Miranda uses her 1.8-kilowatt hair dryer for 0.2 hours, how much electrical energy does she use? Electrical Energy = 1.8 kilowatts 0.2 hours = 0.36 kilowatt-hours Electrical energy use is typically expressed in kilowatt-hours, as in this example. How much energy is this? One kilowatt-hour equals 3.6 million joules of energy. Q: Suppose Miranda were to use a 1.2-kilowatt hair dryer for 0.2 hours. How much electrical energy would she use then? A: She would use: Electrical Energy = 1.2 kilowatts 0.2 hour = 0.24 kilowatt-hours
Output: if an electric device in a 120-volt circuit uses 10 amps of current, then the power of the device is
Le Bassin Aux Nympheas (Water Lily Pond; 1919) is one of the series of Water Lilies paintings by French impressionist artist Claude Monet.
Output: What year was Le Bassin Aux Nymphéas created in?
Hoping to rebound from their home loss to the Titans, the Bears flew to Lambeau Field for a Week 11 NFC North duel with their hated rival, the Green Bay Packers. In the first quarter, Chicago trailed early as Packers QB Aaron Rodgers completed a 3-yard TD pass to WR Greg Jennings. In the second quarter, the Bears got on the board with kicker Robbie Gould getting a 35-yard field goal. Green Bay would answer with RB Ryan Grant getting a 4-yard TD run, along with kicker Mason Crosby getting a 53-yard field goal. In the third quarter, Chicago continued to trail as Rodgers completed a 5-yard TD pass to TE Donald Lee. In the fourth quarter, the Packers pulled away as Crosby made a 33-yard field goal, DE Jason Hunter returned a fumble 54 yards for a touchdown, and Crosby nailing a 45-yard field goal.
Output: Who threw the second longest TD pass?
When you enter a crowded room or go on a picnic or to a party, who is the most attractive and appealing person? It is the person who is cheerful, has a smiling face and behaves as if he or she is enjoying every moment of the event! Such people have an optimistic opinion on life. They are the ones with a positive attitude. On the other hand, let's see that fellow in the corner with a long face. He is most probably thinking about the time and money wasted in having fun. He is a pessimist, one with a negative attitude. A person with a positive attitude gets on well with the job at hand. He doesn't worry about what's gone before or what might happen in the future. If there is a problem, he quickly thinks of ways to solve it. If the problem cannot be solved singly, he seeks help from someone else. He doesn't feel that it's beneath his dignity to seek assistance. When Sonal lost her history notes days before an important examination, she sat down and cried. Then she pulled herself together, borrowed a friend's notes, worked day and night and managed to copy down whatever she had lost. Sonal passed the exam with flying color1s. It's just not possible, even for the greatest optimist, to smile all the time and feel good all day. Everyone has a period of blues now and then, when everything seems sad and without cheer. But once you develop a positive attitude, once you realize that life is a series of ups and downs, dark clouds and bright sunshine, in no time at all, you've _ , ready to welcome the world again with open arms and a huge smile! So from this moment on, keep your face to the sunshine and you'll never see the shadows.
Output: What might be the best title of the passage?
The enzyme telomerase is activated in 80-90% of all human malignancies and immortal cell lines, where it functions to maintain the integrity of chromosomal-end structures called telomeres. Telomerase enzyme activity can be detected in whole cell lysates by a polymerase chain reaction (PCR)-based method referred to as the telomeric repeat amplification protocol (TRAP). The TRAP assay involves extension of an oligonucleotide through telomerase-mediated enzymatic addition of telomeric DNA repeats and subsequent PCR amplification of the extension products. While the TRAP assay as originally developed utilizes radioactively labelled nucleotides, protocols are provided herein for nonradioactive versions of the TRAP assay, with options for either qualitative assessment of TRAP products by polyacrylamide gel electrophoresis (standard TRAP), or quantitative analysis by real-time PCR (Q-TRAP). The Q-TRAP method poses the additional advantages of exquisite sensitivity, rapidity, and potential for adoption to a high-throughput format.
Output: What is the aim of the TRAP assay?
Children with chromosome 22q11.2 deletion syndrome (22q11.2DS), Fragile X syndrome (FXS), or Turner syndrome (TS) are considered to belong to distinct genetic groups, as each disorder is caused by separate genetic alterations. Even so, they have similar cognitive and behavioral dysfunctions, particularly in visuospatial and numerical abilities. To assess evidence for common underlying neural microstructural alterations, we set out to determine whether these groups have partially overlapping white matter abnormalities, relative to typically developing controls. We scanned 101 female children between 7 and 14years old: 25 with 22q11.2DS, 18 with FXS, 17 with TS, and 41 aged-matched controls using diffusion tensor imaging (DTI). Anisotropy and diffusivity measures were calculated and all brain scans were nonlinearly aligned to population and site-specific templates. We performed voxel-based statistical comparisons of the DTI-derived metrics between each disease group and the controls, while adjusting for age. Girls with 22q11.2DS showed lower fractional anisotropy (FA) than controls in the association fibers of the superior and inferior longitudinal fasciculi, the splenium of the corpus callosum, and the corticospinal tract. FA was abnormally lower in girls with FXS in the posterior limbs of the internal capsule, posterior thalami, and precentral gyrus. Girls with TS had lower FA in the inferior longitudinal fasciculus, right internal capsule and left cerebellar peduncle. Partially overlapping neurodevelopmental anomalies were detected in all three neurogenetic disorders. Altered white matter integrity in the superior and inferior longitudinal fasciculi and thalamic to frontal tracts may contribute to the behavioral characteristics of all of these disorders.
Output: What chromosome is affected in Turner's syndrome?
On 6 June 1968, Messerschmitt AG merged with the small civil engineering and civil aviation firm Bolkow, becoming Messerschmitt-Bolkow.
Output: What year was the end of Messerschmitt?
Denis Loginov (born 5 May 1985) is a Russian professional ice hockey forward currently playing for Ertis Pavlodar of Kazakhstan Vyschaya Liga.
Output: Which team does Denis Loginov play for?
The expression of selenoproteins requires the translational recoding of the UGA stop codon to selenocysteine. In eukaryotes, this requires an RNA stem loop structure in the 3'-untranslated region, termed a selenocysteine insertion sequence (SECIS), and SECIS-binding protein 2 (SBP2). This study implicates SBP2 in dictating the hierarchy of selenoprotein expression, because it is the first to show that SBP2 distinguishes between SECIS elements in vitro. Using RNA electrophoretic mobility shift assays, we demonstrate that a naturally occurring mutation in SBP2, which correlates with abnormal thyroid hormone function in humans, lies within a novel, bipartite RNA-binding domain. This mutation alters the RNA binding affinity of SBP2 such that it no longer stably interacts with a subset of SECIS elements. Assays performed under competitive conditions to mimic intracellular conditions suggest that the differential affinity of SBP2 for various SECIS elements will determine the expression pattern of the selenoproteome. We hypothesize that the selective loss of a subset of selenoproteins, including some involved in thyroid hormone homeostasis, is responsible for the abnormal thyroid hormone metabolism previously observed in the affected individuals.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
The Toyota MR2 is a two-seat, mid-engined, rear-wheel-drive sports car manufactured in Japan and marketed globally by Toyota from 1984-2007 over three generations:
Output: What year did Toyota MR2 start?
Angelo Esposito (born February 20, 1989) is a Canadian professional ice hockey player who is currently playing with SG Cortina of the Italian Serie A and who was drafted by the Pittsburgh Penguins in the first round (twentieth overall) of the 2007 NHL Entry Draft.
Output: What team is Angelo Esposito associated with?
Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The chimerical Bcr-Abl protein expressed by CML cells has constitutive tyrosine kinase activity, which is essential for the pathogenesis of the disease. Imatinib, an ATP-competitive selective inhibitor of Bcr-Abl, has unprecedented efficacy for the treatment of CML. Most patients with early stage disease achieve durable complete hematological and complete cytogenetic remissions, with minimal toxicity. In contrast, responses are less stable in patients with advanced CML. This review highlights the pathogenesis of CML, its clinical features, and the development of imatinib as a specific molecularly targeted therapy. Aspects of disease monitoring and side effects are covered as well as resistance to imatinib and strategies to overcome resistance, such as alternative signal transduction inhibitors and drug combinations. Perspectives for further development are also discussed.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
In the county, the population was spread out with 23.5% under the age of 18, 7.8% from 18 to 24, 28.5% from 25 to 44, 25.9% from 45 to 64, and 14.2% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 93.8 males. For every 100 females age 18 and over, there were 90.5 males.
Output: Were there more of the population aged 65 and older or between age 45 to 64?
Excessive neointima formation often occurs after arterial injury. Interleukin-1 (IL-1) is a potent pleiotropic cytokine that has been shown to regulate neointimal proliferation. We investigated the effects of the IL-1 modulator gevokizumab in a rat carotid denudation model. Sprague-Dawley rats were subjected to balloon denudation of the right carotid artery and were then randomized to receive a single subcutaneous infusion immediately after balloon injury of saline (control group, n=13) or gevokizumab (gevokizumab groups, n=15 in each group: 1, 10 and 50mg/kg). We evaluated the treatment effects on carotid intima-media thickness (IMT) using ultrasonography, on endothelial regrowth using Evans Blue staining and on inflammatory response using histology. We also assessed the effects of IL-1 and gevokizumab on human umbilical vein endothelial cells (HUVEC) and rat smooth muscle cells. We found that carotid IMT, in the proximal part of the denuded artery at day 28, was decreased by gevokizumab 1mg/kg compared with controls. Neointima area and the intima/media area ratio were both reduced in the gevokizumab 1 mg/kg-treated group. Gevokizumab at the 1mg/kg dose also improved endothelial regrowth. No effect was observed with gevokizumab 10 or 50mg/kg. Gevokizumab also decreased the inflammatory effect of IL-1 in invitro cell experiments and protected HUVECs from IL-1's deleterious effects on cell migration, apoptosis and proliferation. A single administration of gevokizumab 1mg/kg improves endothelial regrowth and reduces neointima formation in rats following carotid denudation, at least in part through its beneficial effects on endothelial cells.
Output: Which molecule is targeted by the drug Gevokizumab?
The objective of this study was to analyze the expression levels of multiple components in the mammalian target of rapamycin (mTOR) signaling pathway in radical nephrectomy specimens from patients with metastatic renal-cell carcinoma (RCC) treated with mTOR inhibitors in order to identify factors predicting susceptibility to these agents. This study retrospectively included a total of 48 consecutive patients undergoing radical nephrectomy, who were diagnosed with metastatic RCC and subsequently treated with an mTOR inhibitor (everolimus or temsirolimus) as either first- or second-line systemic therapy. Expression levels of 5 molecular markers involved in the signaling pathway associated with mTOR, including PTEN, phosphorylated (p)-Akt, p-mTOR, p-p70 ribosomal S6 kinase, and p-4E-binding protein 1 (4E-BP1), were measured by immunohistochemical staining of primary RCC specimens. Of several factors examined, bone metastasis, liver metastasis, and the expression level of p-4E-BP1 were shown to have significant impacts on the response to the mTOR inhibitors. Progression-free survival (PFS) was significantly correlated with the expression levels of PTEN and p-4E-BP1 in addition to the presence of bone metastasis on univariate analysis. Of these significant factors, p-4E-BP1 expression and bone metastasis appeared to be independently associated with PFS on multivariate analysis. These findings suggest that it would be useful to consider the expression levels of potential molecular markers in the mTOR signaling pathway, particularly p-4E-BP1, as well as conventional clinical parameters when selecting patients with metastatic RCC who are likely to benefit from treatment with mTOR inhibitors.
Output: What does mTOR stands for?
Nivolumab was developed as a monoclonal antibody against programmed death receptor-1, an immune checkpoint inhibitor which negatively regulates T-cell proliferation and activation. Intravenous administration of nivolumab was approved for the treatment of unresectable malignant melanoma in 2014 in Japan. When advanced melanoma patients were treated with nivolumab, median overall survival became longer. Overall survival rate was significantly better in nivolumab-treated melanoma patients than dacarbazine-treated melanoma patients. Nivolumab had an acceptable long-term tolerability profile, with 22% of patients experiencing grade 3 or 4 adverse events related to the drug. Therefore, nivolumab can become an alternative therapy for advanced malignant melanoma.
Output: Which is the target protein of the drug nivolumab?
Transactivation response DNA-binding protein 43 (TDP-43) proteinopathies are classified based upon the extent of modified TDP-43 and include a growing number of neurodegenerative diseases such as amyotrophic lateral sclerosis, frontotemporal lobar degeneration with ubiquitin-immunoreactive, tau-negative inclusions and frontotemporal lobar degeneration with motor neuron disease. The purpose of the study was to examine whether proteolytic modifications of TDP-43 are a relevant finding in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). A novel site-directed caspase cleavage antibody, termed TDP caspase cleavage product antibody (TDPccp), was utilized based upon a known caspase 3 cleavage consensus site within TDP-43 at position 219. Application of this antibody to postmortem brain sections from PD and DLB patients revealed the presence of caspase-cleaved TDP-43 in Lewy bodies and Hirano bodies in all cases examined. Colocalization of TDPccp with an antibody to alpha-synuclein (alpha-Syn), which served as a general marker for Lewy bodies, was evident within the substantia nigra in both alpha-synucleinopathies. Interestingly, the TDPccp antibody detected a greater number of Lewy bodies in PD and DLB compared to the alpha-Syn antibody. In addition, a semiquantitative analysis in both diseases confirmed this finding by indicating that the percentage of caspase-cleaved TDP-43 single-labeled Lewy bodies was approximately twice that of alpha-Syn labeling (in DLB 13.4 vs. 5.5%, while in PD 34.6 vs. 17.6%). Collectively, these data have identified caspase-cleaved TDP-43 as a primary component of Lewy and Hirano bodies in PD and DLB, and suggest that the TDPccp antibody is an effective marker for the detection of Lewy bodies in these neurodegenerative diseases.
Output: Which is the primary protein component of Lewy bodies?
Some people bring out the best in you in a way that you might never have fully realized on your own. My mom was one of those people. My father died when I was nine months old, making my mom a single mother at the age of eighteen. While I was growing up, we lived a very hard life. We had little money, but my mom gave me a lot of love. Each night, she sat me on her lap and spoke the words that would change my life, "Kemmons, you are certain to be a great man and you can do anything in life if you work hard enough to get it." At fourteen, I was hit by a car and the doctors said I would never walk again. Every day,my mother spoke to me in her gentle,loving voice, telling me that no matter what those doctors said, I would walk again if I want to badly enough. She drove that message so deep into my heart that I finally believed her.A year I returned to school--walking on my own ! When the Great Depression hit, my mom lost her job. Then I left school to support the both of us. At that moment, I was determined never to be poor again. Over the years, I experienced various levels of business success. But the real turning point occurred on a vacation I took with my wife and five kids in1951. I was dissatisfied with the second-class hotels available for families and was angry that they charged an extra $2 for each child. That was too expensive for the average American family. I told my wife that I was going to open a motel for families that would never charge extra for children. There were plenty of doubters at that time. Not surprisingly, Mom was one of my strongest supporters. She worked behind the desk and even designed the room style. As in any business,we experienced a lot of challenges. But with my mother's words deeply rooted in my soul, I never doubted we would succeed.Fifteen years later,we had the largest hotel system in the world--Holiday Inn. In 1979 my company had 1759 inns in more than fifty countries with an income of $1billion a year. You may not have started out life in the best situations. But if you can find a task in life worth working for and believe in yourself, nothing can stop you.
Output: According to the author, who played the most role in making him walk back to school again?
The Patriots clinched their fourth straight AFC East title with a close road win. After a scoreless first quarter, the Jaguars responded to a Gostkowski field goal with a Maurice Jones-Drew touchdown run. The Patriots challenged the play, as Jones-Drew appeared to fall down at the line of scrimmage, but the ruling on the field was upheld. New England came back before the halftime to retake the lead at 10-7 on a Dillon one-yard touchdown run. The Patriots maintained their lead as the teams traded touchdowns in the second half, including another touchdown by Jones-Drew. A David Garrard fumble with 1:55 left in the fourth quarter, recovered by safety Rodney Harrison, sealed the Patriots' 11th win of the season.
Output: Which team scored the most in the first half?
As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language.
Output: What country were the people from who made up the smallest ethnic group of the population?
Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light.
Output: Who's parents were in an auto wreck?
In 1959, Michael Courtland (Robertson), a New Orleans real estate developer, has his life shattered when his wife Elizabeth (Bujold) and young daughter Amy are kidnapped. The police recommend that he provide the kidnappers with a briefcase of shredded blank paper instead of the demanded ransom, as the kidnappers will then be more likely to surrender when cornered, rather than attempt to escape with cash in hand. Courtland agrees to this plan. This leads to a bungled car chase in which both kidnappers and victims are killed in a spectacular explosion. Courtland blames himself for the deaths of his wife and daughter. Fifteen years pass. Courtland is morbidly obsessed with his dead wife, and regularly visits a monument he has had built in her memory. The monument is a replica of the church (Basilica di San Miniato al Monte) where he and Elizabeth had met many years before in Florence, Italy. His real estate partner Robert LaSalle (Lithgow) convinces Courtland to tag along on a business trip back to Florence. While there, Courtland revisits the church, and suddenly comes face to face with a young woman named Sandra (Bujold) who looks exactly like his late wife. The already slightly unhinged Courtland begins to court the young woman, and subtly attempts to transform her into a perfect mirror image of his dead wife. Courtland returns to New Orleans with Sandra so they can marry. On their wedding night, Sandra is kidnapped and a ransom note is left behind by her abductors. It is an exact replica of the kidnappers' message from fifteen years before. This time, Courtland decides to deliver the demanded cash. He withdraws massive quantities of money from his accounts and business holdings, financially ruining him and forcing him to sign over his interest in the real estate business to LaSalle. In the process, he discovers that his entire ordeal, including the original kidnapping, had been engineered by LaSalle as a way to gain sole control of Courtland's company share holdings. The now nearly insane Courtland stabs LaSalle to death. Knowing that Sandra must have been a willing accomplice in the plot against him, he goes to the airport to kill the escaping woman. On the plane, Sandra has a flashback to her part in the scheme; she is in fact Courtland's daughter: following the original kidnapping LaSalle concealed her survival and sent her to live in secret with an Italian caretaker. Over the years, LaSalle has told her lies about Courtland, convincing her that her father had not paid the ransom because he didn't love her. Sandra, who has come to love Courtland, attempts suicide on the plane and is taken off the flight in a wheelchair. Courtland sees her and runs toward her, gun drawn. A security guard attempts to stop him but Courtland smashes the briefcase full of money against the guard's head, knocking him unconscious. The briefcase breaks open and all of the money flies out. Sandra, seeing the fluttering bills, stands up and shouts: "Daddy! You brought the money!" Courtland now realizes for the first time who Sandra really is, and father and daughter fall into a deep embrace.
Output: What kind of ransom does the police demand the kidnappers get?
The interpretation of non-coding variants still constitutes a major challenge in the application of whole-genome sequencing in Mendelian disease, especially for single-nucleotide and other small non-coding variants. Here we present Genomiser, an analysis framework that is able not only to score the relevance of variation in the non-coding genome, but also to associate regulatory variants to specific Mendelian diseases. Genomiser scores variants through either existing methods such as CADD or a bespoke machine learning method and combines these with allele frequency, regulatory sequences, chromosomal topological domains, and phenotypic relevance todiscover variants associated to specific Mendelian disorders. Overall, Genomiser is able to identify causal regulatory variants as thetop candidate in 77% of simulated whole genomes, allowing effective detection and discovery of regulatory variants in Mendelian disease.
Output: Which method is available for whole genome identification of pathogenic regulatory variants in mendelian disease?
On 24 July 1867, a part of the territory of Bagnolet was detached and merged with a part of the territory of Romainville and a part of the territory of Pantin to create the commune of Les Lilas.
Output: Which replaced the Bagnolet?
Heat moves in the atmosphere the same way it moves through the solid Earth or another medium. What follows is a review of the way heat flows, but applied to the atmosphere. Radiation is the transfer of energy between two objects by electromagnetic waves. Heat radiates from the ground into the lower atmosphere. In conduction, heat moves from areas of more heat to areas of less heat by direct contact. Warmer molecules vibrate rapidly and collide with other nearby molecules, transferring their energy. In the atmosphere, conduction is more effective at lower altitudes, where air density is higher. This transfers heat upward to where the molecules are spread further apart or transfers heat laterally from a warmer to a cooler spot, where the molecules are moving less vigorously. Heat transfer by movement of heated materials is called convection. Heat that radiates from the ground initiates convection cells in the atmosphere (Figure 1.1). Click image to the left or use the URL below. URL: Different parts of the Earth receive different amounts of solar radiation. Which part of the planet receives the most solar radiation? The Suns rays strike the surface most directly at the Equator. The difference in solar energy received at different latitudes drives atmospheric circulation.
Output: solar energy coming through space is transferred by
Marco Solfrini (born 30 January 1958 in Brescia) is a former basketball player from Italy, who won the silver medal with his national team at the 1980 Summer Olympics in Moscow.
Output: With what sport does Marco Solfrini work with?
After a tough win over the Texans, the Steelers stayed home for a game against the Colts. In the first quarter, the Colts scored first as Adam Vinatieri nailed a 31-yard field goal for a 3-0 lead. However, the Steelers took the lead later on in the quarter when Ben Roethlisberger found Markus Wheaton on an 18-yard TD pass for a 7-3 game. In the 2nd quarter, the Steelers would score again increasing their lead as Roethlisberger found Martavis Bryant on a 5-yard TD pass for a 14-3 game. This was followed by William Gay picking off Andrew Luck and returning it 33 yards for a TD as they increased their lead to 21-3. The Colts however responded as Andrew Luck threw a 21-yard TD pass to Dwayne Allen for a 21-10 game. However, the Steelers pulled away as Roethlisberger would find Antonio Brown on 2 consecutive TD passes: from 8 and 47 yards out to increase their lead at first from 28-10 to 35-10. The Colts responded with 10 straight points first being Luck who found T. Y. Hilton on a 28-yard TD Pass for a 35-17 game followed by Vinatieri kicking a 23-yard field goal before halftime to make the score 35-20. The Steelers went back to work in the 3rd quarter as Roethlisberger and Bryant hooked up again on a 2-yard TD pass to increase their lead making the score 42-20. The Colts however were able to come within 8 later on when Ahmad Bradshaw ran for a 12-yard TD followed by Luck finding Donte Moncrief on a 31-yard TD pass to make the score 42-27 and then 42-34. In the 4th quarter, it was all Steelers when a penalty was enforced on Luck in the end zone for a safety making the score 44-34. The Steelers were able to seal the game later on when Roethlisberger found Heath Miller on an 11-yard TD pass for a final score of 51-34. Roethlisberger set franchise records with 522 yards passing and six touchdowns while picking up his 100th victory in his 150th start. Roethlisberger's yardage total was the fourth highest in NFL history. He became the first player in NFL history to go over 500 yards passing twice as the Steelers won consecutive games for the first time this season.
Output: What quarter did the longest field goal kick of the game happen in?
Karen L. Parker, the first African-American woman undergraduate to attend the University of North Carolina at Chapel Hill, was born in Salisbury, North Carolina and grew up in Winston-Salem, North Carolina.
Output: What university did Karen L. Parker attend?
Finally, in 2001, SV Nord-Nordstern and SC Wedding-Rapide came together to form SV Nord Wedding 1893.
Output: What year did SV Nord Wedding 1893 dissolve?
With headquarters in Elswick, Newcastle upon Tyne, Armstrong Whitworth engaged in the construction of armaments, ships, locomotives, automobiles, and aircraft.
Output: What type of product does Armstrong Whitworth produce?
Jochebed's position in the family tree of Gershon is uncertain.
Output: Who is Gershon's sister?
Greenwich is on the River, five miles from the middle of London, and its history is two thousand years old. The first English people were fishermen there, and they named the place Greenwich, meaning "green village". Later the English kings and queens lived at Greenwich in their beautiful places. The name of the earliest palace was Placentia. Henry VIII lived there. He knew that England must be strong at sea. So he started two big ship-yards at Greenwich. But trouble was coming to Greenwich. In 1649, a war started in England and for eleven years there was no king. The men who had worked for him at Placentia decided to live the place themselves. They sold all its beautiful things. Finally, the war ended and King Charles II came back. But Placentia was falling down. So King Charles built a new and bigger palace, which is now open to the public. At this time, Charles was worried about losing so many of its ships at sea: their sailors did not know how to tell exactly where they were. So in 1675, Charles made John Flamsteed, the first astronomer in England, try to find the answer. Flamsteed worked in a new building on the high ground in Greenwich Park. From it with a telescope which he made himself, Flamsteed could look all round the sky. And he did, night after night, for twenty years. Carrying on Flamsteed's work a hundred years later, an astronomer called Harrison finally made a clock which told the time at sea, and helped sailors to know where they were. You can see Harrison's clock, still working, in Greenwich's museum of the sea. Because of Flamsteed's work, every country in the world now tells its time by Greenwich Time.
Output: Who made the first clock which could tell the time at sea?
I'm sure many of you have seen Star Wars, Jurassic Park, Multiplicity, or many of the other movies that describe cloning. Most of what you see in these movies is false. What you don't know is that cloning could be dangerous, to the clone and to our society as a whole. I think human cloning is wrong mainly for four reasons. What about identity? Humans are promised the right to their own personalities. What would happen if we ignore those rights by giving them someone else's genetic identity? True, Cloning may prevent people from possessing their identities. Also, these is a large power struggle here. Cloning means a degree of power and controls over another person's physical identity and that ignores their rights and their only personalities. The person doing the cloning would have more power than any parent would have. Cloning would also deal with killing embryos . You might not have known, but Dolly, the sheep that was cloned in 1996, was one of over 200 sheep embryos and hers was the only embryo that survived. The rest died or were thrown away. Imagine if the failure rate was that high when we started to clone humans. cloning means running the risk of wasting too much effort Cloning someone, at this present time, would be extremely dangerous to the birth mother and the clone. In studies done on cows, 4 out of 12 birth mothers died. There is a very high failure rate, which is shown in the cloning of Dolly. Even if you had a few good embryos, failures have been noticeable in animal tests. So, should we work ahead in the world of cloning? I say no. the risks are greater than the benefits. It's dangerous to the clone and to the birth mother. We would be killing human lives in the process. It would also be a violation of the clone's right to its own genetic identity and personality.
Output: According to the article, what is the author's opinion about identity?
CNN news-Jan 16,2013 Protests have been going on for about a week now in the northern Irish capital of Belfast. They Started out peacefuily , bus some of them turn violent later on. There is a lot of history behind these protests,and it starts with geography, What's interesting is that Northern Ireland is not part of the republic of Iteland. It,s part of the United Kingdom, and that's what's behind this tension, Nationalists, mostly Catholic, think Northern Ireland should be part of the Republic of Ireland, Unionists, or Loyalists, mostly Protestants, wanted to stay part of the United Kingdom, The conflict between those two groups led to decades of violence ,and more than3,000 people were killed before a peace deal was signed in 1998,The protests happening now are connected to a decision regarding the British flahg ,In Belfast ,the capital of Northern Ireland ,the flag used to fly over City Halll every day of the year , Last month, local officials decided to limit that to 18 days per year. Unionists weren't happy about that . In some cases protesters have thrown concrete blocks, bricks, even weren't happy about that , In some cases protesters have thrown concrete blocks, bricks, even gasoline bombs at police ,Officers have responded by using water cannons to break up the protests. Nest up ,we are heading to the capital of China , Beijing, Experts say that city has something in common with Los Angeles; smog This gray haze is hanging in the air, making things hard to see ,Yesterday, the numbers indicating smog levels were off the charts, A uthorities warn people there to stay inside, Last year nearly 700 flights were canceled at Beijing airports because of haze and smog, Officials in China say that the air quality in the capital has gotten better since Beijing hosted the 2008 Olympics, but residents say the pollution levels have gotten worse.
Output: Which group of people think Ireland should not be divided into two parts?
Transcription factors belonging to the nuclear factor of activated T cells (NFAT) family regulate the expression of cytokine genes and other inducible genes during the immune response. The functions of NFAT proteins are directly controlled by the calcium- and calmodulin-dependent phosphatase calcineurin. Here we show that the binding of calcineurin to NFAT is substantially increased when calcineurin is activated with calmodulin and calcium. FK506.FKBP12 drug-immunophilin complexes inhibited the interaction of NFAT with activated calcineurin much more effectively than they inhibited the interaction with inactive calcineurin, suggesting that part of the interaction with activated calcineurin involved the enzyme active site. We have previously shown that NFAT is targeted to inactive calcineurin at a region distinct from the calcineurin active site (Aramburu, J., Garcia-Cozar, F. J., Raghavan, A., Okamura, H., Rao, A., and Hogan, P. G. (1998) Mol. Cell 1, 627-637); this region is also involved in NFAT binding to activated calcineurin, since binding is inhibited by an NFAT peptide spanning the calcineurin docking site on NFAT. The interacting surfaces are located on the catalytic domain of the calcineurin A chain and on an 86-amino acid fragment of the NFAT regulatory domain. NFAT binding to the calcineurin catalytic domain was inhibited by the calcineurin autoinhibitory domain and the RII substrate peptide, which bind in the calcineurin active site, as well as by the NFAT docking site peptide, which binds to a region of calcineurin distinct from the active site. We propose that, in resting cells, NFAT is targeted to a region of the calcineurin catalytic domain that does not overlap the calcineurin active site. Upon cell activation, displacement of the autoinhibitory domain by calmodulin binding allows NFAT to bind additionally to the calcineurin active site, thus positioning NFAT for immediate dephosphorylation at functional phosphoserine residues.
Output: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
A&W Cream Soda is a cream soda carbonated soft drink introduced by A&W Root Beer in 1986.
Output: In what year did A&W Cream Soda first exist?
The fourteenth week of the season featured a game between 5-7 teams as the Washington Redskins visited Soldier Field. In 48 games, the Redskins led the series 24-23-1 and had won the last five meetings. The Chicago offense took on a Washington defense that excelled against passers, being ranked tenth in the category; Dashon Goldson led all defensive backs in tackles with 95, while Bashaud Breeland led the team in passes defended with 13. The Redskins defensive rush, which had 20 sacks in 2015, was led by Ryan Kerrigan, who has 6.5. Despite such performances, the Redskins rush defense was ranked 29th in yards per carry with 4.64 and 25th in average rushing yards at 124.2. Jeff Joniak writes that the Bears could exploit this with the three-man rushing attack of Matt Forte, Jeremy Langford, and Ka'Deem Carey. On defense, the Bears faced a Kirk Cousins-led offense that focuses on quick passes; Cousins completed a league-high 68.6 percent of his passes, with 7.1 yards per pass. One of Cousins' main targets was tight end Jordan Reed, who scored six touchdowns and led the Redskins in yards after the catch. Rankings-wise, the pass attack was ranked 17th in the league in passing yards per game and 16th for yards per play. Joniak states that the Bears had to force turnovers, and an area was on third down, as five of Cousins' interceptions had been on third down. The Bears won the coin toss and elected to defer. Washington recorded a 15-play, 80-yard drive en route to scoring on Alfred Morris' one-yard touchdown run. After the Bears punted, the Redskins scored again with Cousins' fake read option leading to a three-yard touchdown run in the second quarter. Chicago's woes continued when the offense began the next drive on their own seven-yard line, and despite reaching the Washington 49, Jay Cutler was strip-sacked by Trent Murphy, who recovered the fumble. The Redskins failed to capitalize on the turnover and punted; the following two drives also ended with punts. With 52 seconds left in the first half, the Bears took over at their own 42, and managed to score with 18 seconds left when Cutler threw a 20-yard touchdown pass to Alshon Jeffery. Cousins kneeled once to end the half. After the Bears punted on the first drive of the second half, Cousins threw a five-yard touchdown pass to Reed. The Bears responded with Cutler's nine-yard touchdown pass to Zach Miller, who managed to escape DeAngelo Hall and made contact with Goldson as he reached the endzone. The score was the Bears' first third quarter touchdown of 2015. Afterwards, Cousins' pass for Pierre Garcon was intercepted by Kyle Fuller, and the Bears took advantage with Forte's seven-yard touchdown run to tie the score. Dustin Hopkins gave the Redskins the 24-21 lead on the first drive of the final quarter with a 47-yard field goal. Five drives later, the Bears attempted a 50-yard field goal with 1:40 left in the game. However, Robbie Gould's kick sailed wide left, and the Redskins ran the ball three times to end the game.
Output: Who scored the first touchdown of the game?
Brouwerij Nacional Balashi was founded in 1996 by one of Aruba's largest companies, MetaCorp.
Output: Which city is Balashi located in?
The U.S. Census for 2010 reported 332,199 households in Indianapolis, with an average household size of 2.42 and an average family size of 3.08. Of the total households, 59.3% were family households, with 28.2% of these including the familys own children under the age of 18; 36.5% were husband-wife families; 17.2% had a female householder (with no husband present) and 5.6% had a male householder (with no wife present). The remaining 40.7% were non-family households. , 32% of the non-family households included individuals living alone, 8.3% of these households included individuals age 65 years of age or older.
Output: Which group from the census is larger: family households or husband-wife families?
HD 90089 is a suspected variable star in the constellation Camelopardalis.
Output: What is the constellation that is made with HD 90089?