niryuu/sni-each-converted huggingface dataset:
The origin of brain tumors has attracted much controversy. Recent advances in neural stem cell biology coupled with the new concepts of central nervous system development have raised interesting possibilities regarding the oncogenic properties of neural stem/progenitor cells. To elucidate these putative properties further, the clinical materials from an infant brain tumor were analyzed, focusing on the relation with the neural stem/progenitor cells. The expression of neural stem/progenitor cell markers in the tumor cells and the cellular components of the infant brain tumor were examined using immunohistochemistry. The tumor cell biology was analyzed both in culture and in the grafted brain environment. Three main bodies of evidence were demonstrated indicating that the tumor was of possible subventricular zone postnatal or adult normal neural stem cell origin. First, in the tumor specimen we demonstrated the strong positive expression of the neural stem/progenitor cell markers, nestin and Musashi-1. Second, immunohistochemistry revealed the presence of neuronal, astrocytic, and immature precursor cells in the tumor tissue, similar to the cellular components of the subventricular zone, thereby pointing to the subventricular zone as the possible origin of the tumor. The subventricular zone also is one of the strong candidates for the location of postnatal/adult neural stem cells. This cellular evidence was strengthened further by the clinicoradiological findings that demonstrated the involvement of the subventricular zone of the lateral ventricle by the tumor. Third, in the in vitro and in vivo experiments, a dynamic shift in expression patterns between neural stem cells (nestin, Musashi-1) and differentiated cells (glial fibrillary acidic protein, neuron-specific Class III beta-tubulin) markers was seen, similar to the proposed behavior of postnatal/adult neural stem cells in situ. These findings suggest that this brain tumor originated from neural stem cells located in the subventricular zone, and the further possibility of the general oncogenic potential of neural stem cells.
Output: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
Christianson syndrome is an X-linked mental retardation syndrome characterized by microcephaly, impaired ocular movement, severe global developmental delay, hypotonia which progresses to spasticity, and early onset seizures of variable types. Gilfillan et al.2008] reported mutations in SLC9A6, the gene encoding the sodium/hydrogen exchanger NHE6, in the family first reported and in three others. They also noted the clinical similarities to Angelman syndrome and found cerebellar atrophy on MRI and elevated glutamate/glutamine in the basal ganglia on MRS. Here we report on nonsense mutations in two additional families. The natural history is detailed in childhood and adult life, the similarities to Angelman syndrome confirmed, and the MRI/MRS findings documented in three affected boys.
Output: Mutation of which gene is implicated in the Christianson syndrome?
The Quarrymen (also written as ''the Quarry Men'') are a British skiffle/rock and roll group, formed by John Lennon in Liverpool in 1956, which eventually evolved into the Beatles in 1960.
Output: From what city is the band The Quarrymen?
Cloning is the process of creating an exact genetic replica of an organism. The clones DNA is exactly the same as the parents DNA. Bacteria and other single-celled organisms have long been able to clone themselves through asexual reproduction. Plants can also reproduce asexually. In animals, however, cloning does not happen naturally. In 1997, that all changed when a sheep named Dolly was the first large mammal ever to be successfully cloned. Other animals can now also be cloned in a laboratory. The process of producing an animal like Dolly starts with a single cell from the animal that is going to be cloned. Below are the steps involved in the process of cloning: 1. In the case of Dolly, cells from the mammary glands were taken from the adult that was to be cloned. But other somatic cells can be used. Somatic cells come from the body and are not gametes like sperm or egg. 2. The nucleus is removed from this cell. 3. The nucleus is placed in a donor egg that has had its nucleus removed. The nucleus must be removed from the donor egg to maintain the appropriate chromosome number. 4. The new cell is stimulated with an electric shock and embryo development begins, as if it were a normal zygote. The zygote is the first cell of a new organism. 5. The resulting embryo is implanted into a mother sheep, where it continue its development ( Figure 1.1). To clone an animal, a nucleus from the animals cells are fused with an egg cell (from which the nucleus has been re- moved) from a donor, creating a new zy- gote. Cloning is not always successful. Most of the time, this cloning process does not result in a healthy adult animal. The process has to be repeated many times until it works. In fact, 277 tries were needed to produce Dolly. This high failure rate is one reason that human cloning is banned in the United States. In order to produce a cloned human, many attempts would result in the surrogate mothers experiencing miscarriages, stillbirths, or deformities in the infant. There are also many additional ethical considerations related to human cloning. Can you think of reasons why people are for or against cloning?
Output: which best defines a zygote?
People in the United States honor their parents with two special days: Mother's Day, on the second Sunday in May, and Father's Day, on the third Sunday in June. Mother's Day was proclaimed a day for national observance by President Woodrow Wilson in 1915. Ann Jarvis from Grafton, West Virginia, had started the idea to have a day to honor mothers. She was the one who chose the second Sunday in May and also began the custom of wearing a carnation. In 1909, Mrs. Dodd from Spokane, Washington, thought of the idea of a day to honor fathers. She wanted to honor her own father, William Smart. After her mother died, he had the responsibility of raising a family of five sons and a daughter. In 1910, the first Father's Day was observed in Spokane. Senator Margaret Chase Smith helped to establish Father's Day as a national commemorative day, in 1972. These days are set aside to show love and respect for parents. They raise their children and educate them to be responsible citizens. They give love and care. These two special days are celebrated in many different ways. On Mother's Day people wear carnations. A red one symbolizes a living mother. A white one shows that the mother is dead.Many people attend religious services to honor parents. It is also a day when people whose parents are dead visit the cemetery. On these days families get together at home, as well as in restaurants. They often have outdoor barbecues for Father's Day. These are days of fun and good feelings and memories.
Output: Who plays the most important role in Father's Day becoming a national commemorative day?
Prince Sultan Hamid Mirza Qajar (23 April 1918 -- 5 May 1988) was the head and heir presumptive of the Qajar dynasty, the former ruling dynasty of Iran, and the son of the last Qajar Crown Prince of Iran.
Output: What family lineage was Hamid Mirza part of?
The limited availability of effective drugs causes difficulties in the management of multidrug-resistant tuberculosis (MDR-TB) and novel therapeutic agents are needed. Delamanid , a new nitro-hydro-imidazooxazole derivative, inhibits mycolic acid synthesis. This review covers the efficacy and safety of delamanid for MDR-TB. This paper reviews the pharmacological profile of delamanid and the results of clinical trials evaluating its efficacy for treating MDR-TB in combination with other anti-TB drugs. The drug's safety and tolerability profiles are also considered. Delamanid showed potent activity against drug-susceptible and -resistant Mycobacterium tuberculosis in both in vitro and in vivo studies. In clinical trials, the drug showed significant early bactericidal activity in pulmonary TB patients, and increased culture conversion after 2 months of treatment in combination with an optimized background regimen in MDR-TB patients. In addition, decreased mortality was observed in MDR-TB patients who received > 6 months of delamanid treatment. The drug was generally tolerable, but QT prolongation should be monitored carefully using electrocardiograms and potassium levels. Therefore, delamanid could be used as part of an appropriate combination regimen for pulmonary MDR-TB in adult patients when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability.
Output: Which disease can be treated with Delamanid?
Sotos syndrome is a well-known overgrowth syndrome characterized by excessive growth during childhood, macrocephaly, distinctive facial appearance and learning disability. This disorder is caused by mutations or deletions in NSD1 gene. The aim of this study is to examine the relationship between the neuroimaging and clinical features of children with Sotos syndrome. Six Turkish children with Sotos syndrome were followed up about 3-7 years. The diagnosis was confirmed with molecular genetic analysis. We identified the pathogenic NSD1 mutation including three novel in all patients. All the patients had a characteristic facial gestalt of Sotos syndrome consisting of triangular face with prominent forehead, frontoparietal sparseness of hair and small nose. However, the degree of psychomotor and intellectual development was variable. Severe learning defect and speech delay were remarkable in two patients. The neuroimaging analysis showed abnormalities in four of six patients including bilateral large ventricles, thinning of the corpus callosum and persistent cavum septum pellucidum et vergae. Typical craniofacial appearance is the primary finding for the diagnosis of the disease even in the infantile period. However, the degree of psychomotor and intellectual development is very variable and does not correlate with the neuroimaging findings.
Output: Which gene is responsible for the development of Sotos syndrome?
Adelina Stehle (born Graz, 30 June 1860 -- died Milan, 24 December 1945) was an Austrian-born operatic soprano, associated almost entirely with the Italian repertory.
Output: At what location did Adelina Stehle die?
Labrador Airways Limited, operating as Air Labrador, is a regional airline based in Goose Bay (CFB Goose Bay), Newfoundland and Labrador, Canada.
Output: Which airport does Air Labrador operate in?
The 1980 film Magnificent 72 and the 2011 film 72 Heroes focus on the uprising. Events of the uprising open the 2011 film 1911.
Output: Which film cam out first, in 1980 Magnificent 72 or 2011 72 Heroes?
The median age in the city was 35.1 years. 24.2% of residents were under the age of 18; 7.9% were between the ages of 18 and 24; 33.8% were from 25 to 44; 24.6% were from 45 to 64; and 9.5% were 65 years of age or older. The gender makeup of the city was 48.6% male and 51.4% females.
Output: Which age group had the most people?
Coming off their Thanksgiving win over their divisional foe, the Lions, the Packers flew to Texas Stadium for a Week 13 Thursday night intraconference duel with the throwback-clad Dallas Cowboys. This match-up would see two 10-1 teams face one another for the first time since 1990 when the New York Giants lost to the San Francisco 49ers. Cowboys quarterback Tony Romo faced off against his boyhood idol Brett Favre in the game. The Packers started the game missing two key players of their defense, with injured cornerback Charles Woodson (tied for 7th in the NFL with 4 interceptions) and pass-rushing end Kabeer Gbaja-Biamila (tied for 6th in the NFL with 9.5 sacks) on the inactive list. In the first quarter, Green Bay took the early lead as rookie kicker Mason Crosby completed a 47-yard field goal. On the first play of the Cowboys opening drive, Al Harris stripped the ball from Terrell Owens and side judge Laird Hayes signaled Green Bay ball, but head linesman Derick Bowers overruled him. The only option for Mike McCarthy to challenge on the play, since the whistle was blown, was whether it was a reception - the strip could not be reviewed. The replay upheld the reception and Dallas retained possession. Nick Folk completed a 26-yard field goal to tie the game. Folk also completed a 51-yard field goal, and QB Tony Romo threw a 3-yard TD pass to WR Patrick Crayton. The Packers would end the first quarter with rookie RB Ryan Grant running for a 62-yard touchdown. In the second quarter, Dallas responded with Romo completing a 26-yard TD pass to TE Anthony Fasano and a 10-yard TD pass to WR Terrell Owens. Brett Favre left the game in the second quarter after he hit his right elbow on the helmet of a blitzing Cowboys DB Nate Jones. The throw led to Favre's second interception. Packers quarterback Aaron Rodgers took over for the Packers next series and led the offense on a 74-yard drive, capping it off with an 11-yard TD pass to WR Greg Jennings. In the third, Grant finished off a 69-yard Packer drive with a 1-yard TD run for the only score of the quarter. In the fourth quarter, Romo completed a 4-yard TD pass to Crayton. Mason Crosby kicked a 52-yard field goal with just over 5minutes remaining in the game to pull the Packers within a field goal. Dallas sealed the win as Folk kicked a 25-yard field goal with 1:03 left in the game. The Packers were flagged for a season-high 142 penalty yards.
Output: Who scored the games longest TD?
When it comes to hotel pools, the indoor variety has long been inferior to their outdoor -- often rooftop -- counterparts. But these days, striking decoration, luxury facilities and stunning settings mean many indoor swimming holes can now challenge even the most glamorous of outdoor pools. So go ahead and take a dip at these luxurious indoor pools. The Water Club at Borgata, Atlantic City This nongaming hotel, which is part of the large Borgata complex in Atlantic City, has three indoor pools (and two more outdoors) so there's really no reason for things to get crowded at any of them. A two-lane lap pool is in the two-floor Immersion spa on the 32nd floor and is set against full-length windows that look out to the Atlantic Ocean, the perfect setup for a water workout. An extremely attractive top-floor pool surrounded by lounge chairs, cabanas and lush foliage expresses a more exotic tropical scene than the property's Jersey Shore location. Rooms from $249/ night. www.theborgata.com Altira Macau On the 16th floor of the tallest building on the island of Taipa is the glamorous indoor infinity pool of the impressively massive gaming complex of Altira Macau. It's easy to see why Forbes once named it one of the best hotel pools in the world: One side faces all of the city with crystal-clear floor-to-ceiling windows. Rooms from $235/ night. www.altiramacau.com Waldorf Astoria Chicago The spa at this hotel is done mostly in a stark white, which only further emphasizes the gorgeous rose-design tile-work at the bottom of the pool, giving bathers the feel of swimming over a bed of roses. The 102,600 individually patterned tiles come from Bisazza, an Italian company renowned for its mosaic tile production. Rooms from $435/night, double occupancy. www.waldorfastoriachicagohotel.com The Charles Hotel, Munich One of the largest pools in Munich, at The Charles Hotel, is also one of the most beautiful. The entire spa is outfitted with marble mosaic tiles, mostly in subdued color1s punctuated with red flourishes. At the pool itself, a very pretty mosaic of red coral shows respect to the 19th century Bavarian royalty, the Wittelsbach family, known for its collection of red coral paraphernalia, from dining cups to jewelry. Rooms from $375/ night, double occupancy. www.roccofortehotels.com
Output: In which of the hotel pools can you look out to the city from one of the side?
Saint Peregrine Laziosi (Pellegrino Latiosi) (c. 1260 -- 1 May 1345) is an Italian saint of the Servite Order (Friar Order Servants of Mary).
Output: What group was Peregrine Laziosi a member of?
The Eagles looked to win their 6th game in a row against the winless 49ers. The Eagles got off to a slow start, only leading 3-0 after the first quarter. Late in the second quarter, the Eagles blew the game open. Carson Wentz found tight end Zach Ertz for a 1-yard touchdown in the back of the end zone off of a bootleg pass, and Jalen Mills intercepted rookie QB C.J. Beathard and returned it 37 yards for a touchdown. The 49ers appeared to have some life in the third quarter, following a Carson Wentz interception, leading to a Matt Breida 22 yard touchdown reception. However, the Eagles responded, with Wentz connecting with Alshon Jeffery for a 53-yard touchdown, putting the game out of reach. The Eagles went on to win 33-10 and advanced to 7-1 on the season. Despite the win, the Eagles played a sloppy game in a rainy afternoon at the Linc.
Output: Which player had the longest touchdown catch?
Biologists agree that the ancestor of mitochondria was an alpha-proteobacterium. But there is no consensus as to what constitutes an alpha-proteobacterial gene. Is it a gene found in all or several alpha-proteobacteria, or in only one? Here, we examine the proportion of alpha-proteobacterial genes in alpha-proteobacterial genomes by means of sequence comparisons. We find that each alpha-proteobacterium harbours a particular collection of genes and that, depending upon the lineage examined, between 97 and 33% are alpha-proteobacterial by the nearest-neighbour criterion. Our findings bear upon attempts to reconstruct the mitochondrial ancestor and upon inferences concerning the collection of genes that the mitochondrial ancestor possessed at the time that it became an endosymbiont.
Output: Which species of bacteria did the mitochondria originate from?
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients.
Output: Which gene is involved in CADASIL?
Diffuse Lewy body disease (DLBD) is characterized by the presence of Lewy bodies (LB) in the neurons and neurites of cortical, subcortical, and brain stem structures. Recently, alpha-synuclein (alphaS) has been found to be a central constituent of LB. In DLBD, abnormal accumulation of alphaS has been reported in both neurons and glia, but studies on glial lesions in DLBD have been limited. We examined in detail the constituents and distribution of glial lesions in eight patients with DLBD and report the pathogenesis of the glial lesions. alphaS-positive neuronal cytoplasmic inclusions (NI), neuropil threads (NT), and coiled bodies (CB) showed similar immunostaining profiles. Without pretreatment, NI, NT, and CB were detected by all antibodies against alphaS. The immunostaining profile of star-like astrocytes (SLA) was quite different from those of NI, NT, and CB. A few SLA were stained by an antibody against the non-Abeta component portion of alphaS without pretreatment, but formic acid pretreatment dramatically enhanced SLA immunoreactivity. SLA and CB were found in all eight brains with DLBD. SLA were scarce in the brain stem, but there were hundreds of SLA per visual field at x100 magnification in the temporal cortex of most cases, while CB were found diffusely in both the cerebral cortex and brain stem, similar to NI. This suggests that the pathogenesis of SLA is different from those of NI and CB.
Output: Against which protein is the antibody used for immonostaining of Lewy bodies raised?
The Bacillus anthracis toxin genes, cya, lef, and pag, can be viewed as a regulon, in which transcription of all three genes is activated in trans by the same regulatory gene, atxA, in response to the same signal, CO2. In atxA+ strains, toxin gene expression is increased 5- to 20-fold in cells grown in 5% CO2 relative to cells grown in air. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Here, we used two independent techniques to obtain evidence for additional CO2-induced atxA-regulated genes. First, total protein preparations from atxA4+ and atxA isolates grown in 5% CO2 and in air were examined by two-dimensional electrophoresis. Comparison of the resulting protein patterns indicated that synthesis of non-toxin proteins is influenced by growth in elevated CO2 and the toxin gene regulator, atxA. Second, we generated random transcriptional lacZ fusions in B. anthracis with transposon Tn917-LTV3. Transposon-insertion libraries were screened for mutants expressing CO2-enhanced atxA-dependent beta-galactosidase activity. DNA sequence analysis of transposon insertion sites in 17 mutants carrying CO2- and atxA-regulated fusions revealed 10 mutants carrying independent insertions on the 185-kb toxin plasmid pXO1 which did not map to the toxin genes. The tcr-lacZ fusion mutants (tcr for toxin coregulated) were Tox+, indicating that these genes may not be involved in anthrax toxin gene activation. Our data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins.
Output: Which metabolite activates AtxA?
Recent genome-wide association studies (GWAS) for Caucasians identified several allelic variants associated with increased risk of developing restless legs syndrome (RLS), also known as Willis-Ekbom disease. Although the pathogenic mechanisms of RLS are not entirely understood, it is becoming increasingly evident that many diseases such as RLS can be attributed to an epistasis. The study objectives were to evaluate whether the associations of RLS with all loci determined in previous GWAS for Caucasians can be replicated significantly for the Korean population and to elucidate whether an epistasis plays a role in the pathogenesis of RLS. DNA from 320 patients with RLS and 320 age- and sex-matched controls were genotyped for variants in the RLS loci. A significant association was found for rs3923809 and rs9296249 in BTBD9 (P < 0.0001 and P = 0.001, respectively); the odds ratio (OR) for rs3923809 was 1.61 (P < 0.0001) to 1.88 (P < 0.0001) and the OR for rs9296249 was 1.44 (P = 0.001) to 1.73 (P = 0.002), according to the model of inheritance. The OR for the interaction between rs3923809 in BTBD9 and rs4626664 in PTPRD was 2.05 (P < 0.0001) in the additive model, 1.80 (P = 0.002) in the dominant model and 2.47 (P = 0.004) in the recessive model. There was no significant association between genotypes of all tested single nucleotide polymorphisms and the mean value of serum iron parameters. Our results suggest that the role of BTBD9 in the pathogenesis of restless legs syndrome is more universal across populations than previously reported and more efforts should be focused on the role of epistasis in the genetic architecture of restless legs syndrome.
Output: Willis-Ekbom disease is also known as?
Associacao Desportiva Bahia de Feira play their home games at Estadio Municipal Alberto Oliveira, nicknamed Estadio Joia da Princesa.
Output: In what stadium does Associação Desportiva Bahia de Feira play home games?
Chediak-Higashi syndrome (CHS) is a rare multiorgan disease entity with autosomal recessive inheritance characterized by oculocutaneous albinism, bleeding tendency, recurrent bacterial infections and various neurological symptoms. Intracellular vesicle formation is deficient, resulting in giant granules in many cells, e.g. giant melanosomes in the melanocytes. Diagnosis has been based on morphological examination of peripheral blood and bone marrow, with giant granules seen in cells of the myeloid lineage and in lymphocytes. The ultimate diagnostic test is to look for a mutated LYST gene. Most patients develop an accelerated phase of the disease with deposition of lymphohistiocytes in the liver, spleen, lymph nodes and bone marrow, resulting in hepatosplenomegaly, bone marrow infiltration and haemophagocytosis. Peripheral blood neutropenia becomes more profound as anaemia and thrombocytopenia develop. Most patients succumb before the age of 10 years. Four patients with CHS are described, one of whom is a long-term survivor after successful allogeneic bone marrow transplantation, two succumbed during the accelerated phase and one is living with a chronic form of the disease. Allogeneic bone marrow transplantation from an HLA-matched sibling is the therapy of choice and should be performed early. If there is no matched family donor, an unrelated donor or a placental blood graft is a good alternative. The clinical picture of CHS is heterogeneous and therapeutic decisions need to be made on an individual basis.
Output: Which mutated gene causes the Chédiak–Higashi Syndrome?
Puffy hand syndrome is a complication of intravenous drug abuse, which has no current available treatment. Arm and forearm edema are voluminous and cause functional and aesthetic disturbances. We report two cases successfully treated by low-stretch bandages. A 40-year-old man and a 34-year-old woman, both intravenous drug users, with puffy hand syndrome were hospitalized for 11 days. Treatment included daily multilayer bandaging. Lymphedema volumes calculated by utilizing the formula for a truncated cone decreased by 16% on the left side and 12% on the right side for the first patient and 31 and 17% for the second. Hand circumference decreased 4.3 cm on the left side and 3.2 cm on the right side in case 1, and 2.5 cm and 1.9 cm respectively for case 2. The patients were taught self-bandaging techniques during their hospital stays. Elastic gloves were fitted at the end of treatment. Reduction of lymphedema volume remained stable after 18 months in one patient while for the second patient further treatment and hospitalization were required due to poor compliance. The pathogenesis of this edema is probably multifactorial: venous, lymphatic insufficiency and the direct toxicity of injected drugs. Lymphedema treatment currently consists of low-stretch bandaging and wearing elastic garments, which is effective in decreasing the volume of puffy hand syndrome.
Output: What causes "Puffy hand syndrome"?
"An apple a day keeps the doctor away" is one of the most common sayings in the English languages. This is because apples were one of the first foods that medical professionals recognized as healthy---their benefits became obvious when, quite simply, doctors found that people who ate apples were sick less often than those who did not. Today we have a more specific understanding of why apples are so beneficial to overall health. Apples can help keep your levels of bad cholesterol down. The pectin in apples helps you to maintain cardiovascular health and reduce LDL cholesterol(which is the "bad" kind). Apples themselves do not add cholesterol to your diet and are full of water and fiber to help weaken the cholesterol in other foods you might digest. According to Health Diaries, people who eat two apples per day may lower their cholesterol by as much as 16 percent. Apples are naturally low in calories and high in water content. Eating an apple can satisfy your hunger and keep you from reaching for high-sugar, high-calories snacks. By eating apples, you will be more able to maintain a healthy weight because they fill you up, potentially stopping you from eating food that encourages a waistline increase. Apples contain considerable levels of boron , which helps build healthy bones, and can also prevent diseases like arthritis. Apples are rich in vitamin C, which is known to help build immunity. Studies have shown that apples can decrease the risk of breast cancer and liver cancer. One theory is that the apple skins are responsible for this, so be sure not to take apple skins off before you eat them, as you could remove some of the health benefits.
Output: Which plays an important role in reducing the risk of breast cancer?
In 1989, Z Channel faded to black and was replaced by SportsChannel Los Angeles.
Output: Which replaced the Z Channel?
Mirza Tahir Hussain (born 1 June 1970) is a British man paroled on 17 November 2006 after spending 18 years on death row in Pakistan for the murder of a taxicab driver named Jamshed Khan in 1988, a crime which he says he committed in self-defence, as Khan pulled out a gun and tried to sexually assault him.
Output: Which crime Mirza Tahir Hussain is considered to have commited?
Todo Noticias (also known as TN) is an Argentine news cable channel.
Output: Which industry is Todo Noticias associated with?
We describe the clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis (CF) from the U.S. CF center with the highest MRSA prevalence. Medical records of children with CF were retrospectively reviewed from 1997-2009. MRSA clinical isolates from 2007-2009 were analyzed by polymerase chain reaction and pulsed field gel electrophoresis. The prevalence of MRSA was 1% in 1997 and 49% in 2009. Fifty-five children (26%) had persistent MRSA infection. Sixty-eight percent of MRSA isolates were hospital-associated (HA) MRSA, of which 52% were pulsed-field type USA 100. Ninety-three percent of HA MRSA isolates were clindamycin resistant. Twelve children acquired MRSA before 1 year of age, 83% of whom were hospitalized prior to acquisition of MRSA. Ten of 11 sibling pairs carried indistinguishable MRSA strains. Children with persistent MRSA were hospitalized more often (P=.01), required inhaled medications more frequently (P=.01), and had higher rates of Pseudomonas aeruginosa coinfection (P<.001). MRSA prevalence in children with CF is increasing, and most children are infected with HA MRSA. Exposure to health care facilities and gastrointestinal surgeries may facilitate early acquisition of MRSA. Siblings carry indistinguishable MRSA strains, indicating household transmission of MRSA. Children with persistent MRSA had worse pulmonary morbidity. Coinfection with MRSA and P aeruginosa is likely associated with further increased pulmonary morbidity.
Output: What is MRSA?
Boiler rooms are often dirty and steamy,but this one is clean and cool.Fox Point is a very new 47unit living building in South Bronx,one of the city's poorest areas.Twothirds of the people living there are formerly homeless people,whose rent is paid by the government.The rest are lowincome families.The boiler room has special equipment,which produces energy for electricity and heat.It reuses heat that would otherwise be lost to the air,reducing carbon emissions while also cutting costs. Fox Point is operated by Palladia,a group that specializes in providing housing and services to needy people.Palladia received support from Enterprise Community Partners (ECP),which helps build affordable housing by providing support to housing developers. ECP has created national standards for healthy,environmentally clever and affordable homes which are called the Green Communities Standards.These standards include water keeping,energy saving and the use of environmentally friendly building materials.Meeting the standards increases housing construction costs by 2%,which is rapidly paid back by lower running costs.Even the positioning of a window to get most daylight can help save energy. Michael Bloomberg,New York's mayor,plans to create 165,000 affordable housing units for 500,000 New Yorkers.Almost 80% of New York City's greenhouse gas emissions come from buildings,and 40% of those are caused by housing.So he recently announced that the city's Department of Housing and Preservation and Development (DHPD),whose duty is to develop and keep the city's supply of affordable housing,will require all its new projects to follow ECP's green standards. Similar measures have been taken by other cities,such as Cleveland and Denver,but New York's DHPD is the largest city developer of affordable housing in the country.(2010*,B)
Output: What is an advantage of the buildings meeting the Green Communities Standards?
Punarvasu) is a Nakshatra in Hindu astrology, which refers to the two brightest stars in the constellation of Gemini:
Output: What constellation does Punarvasu belong to?
Earth formed at the same time as the other planets. The history of Earth is part of the history of the Solar System. Earth came together (accreted) from the cloud of dust and gas known as the solar nebula nearly 4.6 billion years ago, the same time the Sun and the rest of the solar system formed. Gravity caused small bodies of rock and metal orbiting the proto-Sun to smash together to create larger bodies. Over time, the planetoids got larger and larger until they became planets. When Earth first came together it was really hot, hot enough to melt the metal elements that it contained. Earth was so hot for three reasons: Gravitational contraction: As small bodies of rock and metal accreted, the planet grew larger and more massive. Gravity within such an enormous body squeezes the material in its interior so hard that the pressure swells. As Earths internal pressure grew, its temperature also rose. Radioactive decay: Radioactive decay releases heat, and early in the planets history there were many ra- dioactive elements with short half lives. These elements long ago decayed into stable materials, but they were responsible for the release of enormous amounts of heat in the beginning. Bombardment: Ancient impact craters found on the Moon and inner planets indicate that asteroid impacts were common in the early solar system. Earth was struck so much in its first 500 million years that the heat was intense. Very few large objects have struck the planet in the past many hundreds of millions of year. When Earth was entirely molten, gravity drew denser elements to the center and lighter elements rose to the surface. The separation of Earth into layers based on density is known as differentiation. The densest material moved to the center to create the planets dense metallic core. Materials that are intermediate in density became part of the mantle (Figure 1.1). Lighter materials accumulated at the surface of the mantle to become the earliest crust. The first crust was probably basaltic, like the oceanic crust is today. Intense heat from the early core drove rapid and vigorous mantle convection so that crust quickly recycled into the mantle. The recycling of basaltic crust was so effective that no remnants of it are found today. There is not much material to let us know about the earliest days of our planet Earth. What there is comes from three sources: (1) zircon crystals, the oldest materials found on Earth, which show that the age of the earliest crust formed at least 4.4 billion years ago; (2) meteorites that date from the beginning of the solar system, to nearly 4.6 billion years ago (Figure 1.2); and (3) lunar rocks, which represent the early days of the Earth-Moon system as far back as 4.5 billion years ago.
Output: which is not a reason why earth was molten in its early days?
Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 trials with malaria vaccine candidate RTS,S/AS01 (RTS,S) in children has demonstrated modest efficacy against clinical and severe malaria. RTS,S targets the pre-erythrocytic phase of the disease and induces high antibody titers against the P. falciparum circumsporozoite protein (CSP) and a moderate CD4(+) T cell response. The individual contribution of these adaptive immune responses to protection from infection remains unknown. Here, we found that prophylactic administration of anti-CSP mAbs derived from an RTS,S-vaccinated recipient fully protected mice with humanized livers from i.v.- and mosquito bitedelivered P. falciparum sporozoite challenge. Titers of anti-CSP that conveyed full protection were within the range observed in human RTS,S vaccine recipients. Increasing anti-CSP titers resulted in a dose-dependent reduction of the liver parasite burden. These data indicate that RTS,S-induced antibodies are protective and provide sterilizing immunity against P. falciparum infection when reaching or exceeding a critical plasma concentration.
Output: RTS S AS01 vaccine was developed to prevent which disease?
The Indianapolis Colts came into a crucial divisional matchup with the Jacksonville Jaguars, with added importance after the season opening loss to the Texans. With the first possession of the ballgame, the Colts drove down the field with a mix of pass and run plays, scoring the opening touchdown of the game. However, Jacksonville returned the favor by going 76yards to tie the game up, and by the end of the first quarter the game was tied at 7-7. In the second quarter Maurice Jones-Drew scored on a touchdown run giving the Jaguars their first lead of the day, with the Colts eventually responded and tying the up 14-14 going into halftime. With the beginning of the second half both teams failed to score on their next possessions, with the Colts punting to the Jaguars midway through the third quarter. David Garrard threw his first touchdown pass of the day, giving the Jaguars a 21-14 lead towards the end of the third quarter. With the Colts trailing midway through the fourth quarter, Peyton Manning drove the team down the field to score on a Joseph Addai run. With the Jaguars responding and the Colts driving down the field to tie with 0:52 left, the game was a 28-28 with less than thirty seconds in the game. Jacksonville was able to get two big plays on their last drive of the game setting up Josh Scobee for a 59-yard field goal, which was good. The Indianapolis Colts started 0-2 in the AFC South for the first time following this loss, dropping out of first place and falling behind the Houston Texans.
Output: The game was tied before the beginning of what quarter?
Soon after Paradox Interactive took over publishing duties a new bundle was released on April 17, 2009 called Sword of the Stars:
Output: What is the name of the publisher of Sword of the Stars?
Jefte Betancor Sanchez (born 6 July 1993) is a Spanish footballer who plays for UD Las Palmas Atletico as a forward.
Output: What is the date of birth for Jefté Betancor?
Rosiglitazone, a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist, prevents cell death after cerebral ischemia in animal models, but the underlying mechanism has not been clarified. In this study, we examined how rosiglitazone protects neurons against ischemia. Mice treated with rosiglitazone were subjected to 60 minutes of focal ischemia followed by reperfusion. Rosiglitazone reduced infarct volume after ischemia and reperfusion. We show that this neuroprotective effect was reversed with a PPAR antagonist. Western blot analysis showed a significant increase in expression of phosphorylated stress-activated protein kinases (c-Jun N-terminal kinase (JNK) and p38) in ischemic brain tissue. Rosiglitazone blocked this increase. Furthermore, we observed that rosiglitazone increased expression of the dual-specificity phosphatase 8 (DUSP8) protein and messenger RNA in ischemic brain tissue. Dual-specificity phosphatase 8 is a mitogen-activated protein kinase phosphatase that can dephosphorylate JNK and p38. Another key finding of the present study was that knockdown of DUSP8 in primary cultured cortical neurons that were subjected to oxygen-glucose deprivation diminished rosiglitazone's effect on downregulation of JNK phosphorylation. Thus, rosiglitazone's neuroprotective effect after ischemia is mediated by blocking JNK phosphorylation induced by ischemia via DUSP8 upregulation.
Output: Which protein is affected by dusp8 activation?
Many genetic disorders are caused by mutations in one or a few genes. Others are caused by chromosomal mutations. Some human genetic disorders are X-linked or Y-linked, which means the faulty gene is carried on these sex chromosomes. Other genetic disorders are carried on one of the other 22 pairs of chromosomes; these chromosomes are known as autosomes or autosomal (non-sex) chromosomes. Some genetic disorders are due to new mutations, others can be inherited from your parents. Some genetic disorders are caused by recessive alleles of a single gene on an autosome. An example of autosomal recessive genetic disorders are Tay-Sachs disease and cystic fibrosis. Children with cystic fibrosis have excessively thick mucus in their lungs, which makes it difficult for them to breathe. The inheritance of this recessive allele is the same as any other recessive allele, so a Punnett square can be used to predict the probability that two carriers of the disease will have a child with cystic fibrosis. Recall that carriers have the recessive allele for a trait but do not express the trait. What are the possible genotypes of the offspring in the following table ( Table 1.1)? What are the possible phenotypes? F FF (normal) Ff (carrier) F f f Ff (carrier) ff (affected) According to this Punnett square, two parents that are carriers (Ff ) of the cystic fibrosis gene have a 25% chance of having a child with cystic fibrosis (ff ). The affected child must inherit two recessive alleles. The carrier parents are not affected. Tay-Sachs disease is a severe genetic disorder in which affected children do not live to adulthood, so the gene is not passed from an affected individual. Carriers of the Tay-Sachs gene are not affected. How does a child become affected with Tay-Sachs? Huntingtons disease is an example of an autosomal dominant disorder. This means that if the dominant allele is present, then the person will express the disease. A child only has to inherit one dominant allele to have the disease. The disease causes the brains cells to break down, leading to muscle spasms and personality changes. Unlike most other genetic disorders, the symptoms usually do not become apparent until middle age. You can use a simple Punnett square to predict the inheritance of a dominant autosomal disorder, like Huntingtons disease. If one parent has Huntingtons disease, what is the chance of passing it on to the children? If you draw the Punnett square, you will find that there is a 50 percent chance of the disorder being passed on to the children.
Output: for a child to have cystic fibrosis, the child had to
In 1994, the Mexican magazine Somos published a list of ''The 100 best movies of the cinema of Mexico'' in its 100th edition and choose El compadre Mendoza the 3rd better of all time, just behind Vamonos con Pancho Villa and Los olvidados.
Output: Which place is El compadre Mendoza in?
Both restless legs syndrome ([RLS], also known as Willis-Ekbom Disease [WED]) and depression are common during pregnancy. However, no prior studies have assessed if pregnant women with RLS have an elevated risk of depression during and/or after pregnancy. 1,428 women who were pregnant in gestational week 16-17 were asked to participate in a longitudinal survey. They were followed by web-based questionnaires in gestational week 17 and 32, and 6 weeks after delivery. Data were also retrieved from prenatal and birth records. Two different sets of criteria were used to examine the prevalence of RLS in the cohort (International Restless Legs Syndrome Society Group standard criteria and the later developed CH-RLSQ11 questionnaire). The latter questionnaire attempts to exclude those with common "mimics" of RLS. Adjusted odds ratio for depression in gestational week 17, 32, and postpartum week 6 in relation to pre-pregnancy RLS onset and moderate to severe symptom severity were 4.74 (2.30 - 9.76), 3.67 (1.85 - 7.28), and 2.58 (1.28 - 5.21), respectively. No significant associations were seen in pregnant women with de novo RLS during pregnancy. When using the standard diagnostic RLS criteria and frequency of symptoms more than 2-3 days per week, the prevalence of RLS was 12.3%. With the CH-RLSQ11 questionnaire and the same threshold for frequency of symptoms the prevalence was 6.5%. Women with RLS onset before pregnancy with moderate or severe symptoms had an increased risk of both antenatal and postnatal depression. The self-reported prevalence of RLS during pregnancy is lower when a questionnaire dealing with "mimics" is used.
Output: Willis-Ekbom disease is also known as?
Chronic myelogenous leukemia (CML) accounts for 15-20% of adult leukemias but is very rare in children (2%). Fewer than 10% of CML patients are younger than 20 years. CML is a myeloproliferative disorder characterized by the presence of the Philadelphia chromosome or the BCR-ABL fusion oncogene. The objective of this paper is to present the monitoring of imatinib therapy in two children with CML by the BCR-ABL fusion gene expression assessment from peripheral blood with quantitative real-time polymerase chain reaction (PCR) method. The 18 and six months follow-up of the patients included clinical examination, routine laboratory tests, bone marrow aspirate investigation including cytogenetic tests and the major BCR-ABL fusion gene expression measurement with qRT-PCR method from the peripheral blood. Patient No. 1 diagnosed with chronic phase CML showed excellent adherence to daily 400 mg imatinib treatment and achieved complete hematologic (CHR) and cytogenetic response (CCR) by three months and major molecular response (MMR) by 12 months, with lack of side effects due to imatinib. Patient No. 2 experienced severe hematologic toxicity, which necessitated temporary withdrawal of the drug. Transient non-compliance together with imatinib dose reduction has driven to treatment failure. In this case, mutational analysis is warranted. BCR-ABL fusion gene expression level measurement from peripheral blood with qRT-PCR method is an excellent tool in the follow-up of CML patients.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?