niryuu/sni-each-converted huggingface dataset:
As people in China celebrated Singles' Day on November 11, the media eagerly discussed why so many marriageable young people fail to find their other half. While single people in China are pitied, their counterparts in some Western countries feel they are being discriminated against. In the US, where more than a quarter of all households consists of one person, single people often pay more insurance than married people. They don't get the same tax breaks and they seldom get promoted at work. There seems to be a bad name attached to their status - somehow their personality is flawed and therefore they are not to be trusted. Activities have created the term "singlism" to describe discrimination against unmarried people. It means stereotyping , stigmatizing and discrimination against those who are single. Globally, the number of people living alone is skyrocketing. Many people are at peace with being single and some even choose to remain single. But why are so many of us worried about singledom? Michael Cobb, professor of English at the University of Toronto in Canada, says that pop culture is to blame for people's fear of singledom. His book Single: Arguments for the Uncoupled is a critical examination of singleness in favor of the couple, making singletons one of the most despised sexual minorities in Western countries. In pop culture, singles are viewed as immature, whereas fully adults are able to form relationships and live meaningful lives. The overall message is clear: go ahead and be yourself, but if you want real happiness, make sure you get coupled up. You may get that idea from US comedy series Sex and the City and the most recent Girls, or UK's Bridge Jones' Diary.
Output: In Michael Cobb's opinion, what should be responsible for people's fear of singledom?
Human apolipoprotein E (apoE) is a 299-amino-acid protein with a molecular weight of 34 kDa. The difference between the apoE3 and apoE4 isoforms is a single residue substitution involving a Cys-Arg replacement at residue 112. ApoE4 is positively associated with atherosclerosis and late-onset and sporadic Alzheimer's disease (AD). ApoE4 and its C-terminal truncated fragments have been found in the senile plaques and neurofibrillary tangles in the brain of AD patients. However, detail structural information regarding isoform and domain interaction remains poorly understood. We prepared full-length, N-, and C-terminal truncated apoE3 and apoE4 proteins and studied their structural variation. Sedimentation velocity and continuous size distribution analysis using analytical ultracentrifugation revealed apoE3(72-299) as consisting of a major species with a sedimentation coefficient of 5.9. ApoE4(72-299) showed a wider and more complicated species distribution. Both apoE3 and E4 N-terminal domain (1-191) existed with monomers as the major component together with some tetramer. The oligomerization and aggregation of apoE protein increased when the C-terminal domain (192-271) was incorporated. The structural influence of the C-terminal domain on apoE is to assist self-association with no significant isoform preference. Circular dichroism and fluorescence studies demonstrated that apoE4(72-299) possessed a more alpha-helical structure with more hydrophobic residue exposure. The structural variation of the N-terminal truncated apoE3 and apoE4 protein provides useful information that helps to explain the greater aggregation of the apoE4 isoform and thus has implication for the involvement of apoE4 in AD.
Output: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
Wouter Claes (born 28 October 1975 in Leuven, Belgium) is a male left-handed Belgian badminton player.
Output: What is the sex or gender of Wouter Claes?
Glamour Gal is a 1945 propaganda film documentary film about the eponymous large artillery gun and the ten Marines who work her, ''a team of eleven''.
Output: What year was Glamour Gal released?
Sodium glucose cotransporter 2 (SGLT2) is the main luminal glucose transporter in the kidney. SGLT2 inhibition results in glycosuria and improved glycaemic control. Drugs inhibiting this transporter have recently been approved for clinical use and have been suggested to have potential renoprotective benefits by limiting glycotoxicity in the proximal tubule. We aimed to determine the renoprotective benefits of empagliflozin, an SGLT2 inhibitor, independent of its glucose lowering effect. We induced diabetes using a low dose streptozotocin protocol in 7-8 week old endothelial nitric oxide (eNOS) synthase knockout mice. We measured fasting blood glucose on a monthly basis, terminal urinary albumin/creatinine ratio. Renal histology was assessed for inflammatory and fibrotic changes. Renal cortical mRNA transcription of inflammatory and profibrotic cytokines, glucose transporters and protein expression of SGLT2 and GLUT1 were determined. Outcomes were compared to diabetic animals receiving the angiotensin receptor blocker telmisartan (current best practice). Diabetic mice had high matched blood glucose levels. Empagliflozin did not attenuate diabetes-induced albuminuria, unlike telmisartan. Empagliflozin did not improve glomerulosclerosis, tubular atrophy, tubulointerstitial inflammation or fibrosis, while telmisartan attenuated these. Empagliflozin did not modify tubular toll-like receptor-2 expression in diabetic mice. Empagliflozin did not reduce the upregulation of macrophage chemoattractant protein-1 (MCP-1), transforming growth factor 1 and fibronectin mRNA observed in the diabetic animals, while telmisartan decreased transcription of MCP-1 and fibronectin. Empagliflozin increased GLUT1 mRNA expression and telmisartan increased SGLT2 mRNA expression in comparison to untreated diabetic mice. However no significant difference was found in protein expression of GLUT1 or SGLT2 among the different groups. Hence SGLT2 inhibition does not have renoprotective benefits independent of glucose lowering.
Output: Which protein does empagliflozin inhibit?
Mr. Eckerd at the end of the street was a different fellow with a different kind of house. He let kids from the neighborhood come to see his house, but only if they had written permission from their parents, and if he'd already spoken to the parents before. What made it so different? He shared his home with rescued animals that the county couldn't keep. He had the permission to have things like monkeys, large cats, and other strange creatures. His house had the ivy -covered brick wall and the iron gate across the driveway. Once you went inside, the hedges lining the driveway were carved into the shapes of animals. There were other pretty plants on the grounds, too. The old brick house held a lot of surprises. The double doors with the lion's head door knockers opened into a large flat entryway. In the wooden board walls all around, there were fish tanks with colorful fishes. The ceilings were painted with scenes of plants and rare animals. Room opened off from there. Continuing down the hall, you came to a large courtyard, which had been caged in, partly open to the sky .A large group of tiny monkeys shook up and down trees. You had to walk through a caged tunnel into other parts of the house. They called out to whoever walked in, hoping for treats of fruits, nuts, and seeds. Behind that, the hall continued to a room full of snakes and lizards. It felt like a desert in that room, so dry and hot. It was not everyone's favorite room, but it certainly was interesting. The final room was actually out back, and definitely not something to miss. It was much like a large glass bird cage or a greenhouse. It was there that you would usually find Mr Eckerd on a bench next to some carvings of jungle animals. He was watching the Bengal tiger that wandered back and forth inside the cage. Mr. Eckerd's house was the strangest and most unique place in town, a place very well worth seeing.
Output: What exhibit or animal room seemed to be the least popular for most people?
The tradition of birthday parties started in Europe a long time ago. It was feared that evil spirits were particularly attracted to people on their birthdays. To protect them from harm, friends and family members would come to stay with the birthday person and bring good thoughts and wishes. Giving gifts brought even more good cheer to keep away from the evil spirits. This is how birthday parties began. The following are some countries' birthday traditions: Canada---Putting butter on the nose. In Atlantic Canada, the birthday child's nose is put butter on for good luck. China---Noodles for lunch. The birthday child pays respect to his / her parents and receives a gift of money. Friends and relatives are invited to lunch and noodles are served to wish the birthday child a long life. England---Money cakes. Certain symbolic objects are mixed into the birthday cake as it is being prepared. If your piece of cake has a coin in it, you will be rich. Ireland---Birthday bump . The birthday child is lifted upside down and " bumped" on the floor for good luck. Italy---Pulling ears. The child's ears are pulled as many times as how old he / she is turning. Japan---New clothes. The birthday child wears new clothes to mark the occasion. New Zealand---Birthday claps. After the candles are hit, the happy birthday song is sung loudly and often out of tune and then the birthday person receives a clap for each year he / she has been alive and then one for good luck. The United States---Cake, candles and the birthday song. A cake is made, and candles are put on top based on how old the person is.
Output: According to the passage, in which country can the birthday children probably receive a gift of money?
A persons genome is all of his or her genetic information. In other words, the human genome is all the information that makes us human. And unless you have an identical twin, your genome is unique. No one else has a genome just like yours, though all our genomes are similar. The Human Genome Project ( Figure 1.1) was an international effort to sequence all 3 billion bases that make up our DNA and to identify within this code more than 20,000 human genes. Scientists also completed a chromosome map, identifying where the genes are located on each of the chromosomes. The Human Genome Project was completed in 2003. Though the Human Genome Project is finished, analysis of the data will continue for many years. To say the Human Genome Project has been beneficial to mankind would be an understatement. Exciting applications of the Human Genome Project include the following: The genetic basis for many diseases can be more easily determined. Now there are tests for over 1,000 genetic disorders. The technologies developed during this effort, and since the completion of this project, will reduce the cost of sequencing a persons genome. This may eventually allow many people to sequence their individual genome. Analysis of your own genome could determine if you are at risk for specific diseases. Knowing you might be genetically prone to a certain disease would allow you to make preventive lifestyle changes or have medical screenings. To complete the Human Genome Project, all 23 pairs of chromosomes in the human body were sequenced. Each chromo- some contains thousands of genes. This is a karyotype, a visual representation of an individuals chromosomes lined up by size. The video Our Molecular Selves discusses the human genome, and is available at or . Genome, Unlocking Lifes Code is the Smithsonian National Museum of Natural Historys exhibit on the human genome. See [Link] to visit the exhibit. Click image to the left or use the URL below. URL:
Output: analysis of your own genome
Twofish is related to the earlier block cipher Blowfish.
Output: The Twofish is based upon what?
Many mutations of the NF1 gene have been reported in patients with neurofibromatosis type 1 (NF1); however, there have been no documented NF1 gene mutations in Japanese NF1 patients. In the present study, we used the polymerase chain reaction (PCR) and DNA sequencing analysis to characterize the NF1 gene in a 53-year-old Japanese patient with NF1 who suffered from neurofibroma, pheochromocytoma, and gastrointestinal stromal tumor (GIST). Direct sequence analyses revealed a single base substitution in the splicing donor site of intron 6 (IVS6 888+1, G --> A) in one NF1 allele, resulting in an altered splice site (ss) in the mutated allele. Splicing at the cryptic 5' ss in the mutated allele generated mRNA with an insertion of 60 nucleotides. In addition, we screened for mutations in exons 9, 11, 13, and 17 of the c-kit gene in GIST and the succinate dehydrogenase subunit D (SDHD) gene in the pheochromocytoma, but we did not detect any somatic mutations. We report here the first case of an NF1 patient with four neoplasms: neurofibroma, pheochromocytoma, astrocytoma and GIST. Our results suggest that the molecular pathogenesis of GISTs in NF1 patients is different from that in non-NF1 patients.
Output: Which is the gene mutated in type 1 neurofibromatosis?
In 1921, the Corn Palace was rebuilt once again, with a design by the architectural firm Rapp and Rapp of Chicago.
Output: When was Corn Palace opened officially?
Past presidents of PEN International have included Alberto Moravia, Heinrich Boll, Arthur Miller, Mario Vargas Llosa, Homero Aridjis, Jiri Grusa and John Ralston Saul.
Output: Who led PEN International?
The Raiders travelled to face the San Diego Chargers with a chance to secure their first playoff bid since 2002. In a stadium at least half full of Raider fans, the Chargers took an early lead on a pass from Philip Rivers to Travis Benjamin to put the Chargers up 7-0. The Raiders responded with an 11-play drive that stalled on the Charger 27-yard line and had to settle for a Sebastian Janikowski field goal to narrow the lead to 7-3. Neither team could muster anything offensively for the remainder of the quarter. A promising Raider drive to the Charger 16-yard line stalled again as Derek Carr was intercepted inside the 10-yard line. A Charger field goal following a 14-play drive put the Chargers up 10-3 with 1:33 left in the half. The Raider offense switched to their two-minute offense and cruised down the field before Carr hit Michael Crabtree in the corner of the end zone to tie the game at 10. The Raider offense drove deep into San Diego territory to open the second half, but had to settle for another Janikowski field goal to take the lead 13-10. The Chargers answered with a Rivers seven-yard touchdown pass to Hunter Henry to retake the lead. A missed extra point left the lead at 16-13. The remainder of the third quarter saw the offenses accomplish little before Charger running back Kenneth Farrow fumbled at the San Diego 14 early in the fourth quarter. The Raiders offense could not take advantage of the turnover and settled for Jankowski's third field of the game to tie it at 16. The Raider defense again stopped the Chargers and the offense, lead by Latavius Murray and Jalen Richard, moved the ball into San Diego territory again. For the fourth time, the offense settled for a Janikowski field goal to take the lead 19-16 with 3:47 remaining. On the ensuing San Diego possession, Rivers was intercepted by Reggie Nelson to allow the Raiders to take over and run out the clock. The win gave the Raiders their first playoff appearance since 2002. With a loss earlier in the day by Kansas City, the Raiders also took back first place in the AFC West.
Output: How caught the only Raiders touchdown?
Several Nox family NADPH oxidases function as multicomponent enzyme systems. We explored determinants of assembly of the multicomponent oxidases Nox1 and Nox3 and examined the involvement of Rac1 in their regulation. Both enzymes are supported by p47phox and p67phox or homologous regulators called Noxo1 and Noxa1, although Nox3 is less dependent on these cofactors for activity. Plasma membrane targeting of Noxa1 depends on Noxo1, through tail-to-tail interactions between these proteins. Noxa1 can support Nox1 without Noxo1, when targeted to the plasma membrane by fusing membrane-binding sequences from Rac1 (amino acids 183 to 192) to the C terminus of Noxa1. However, membrane targeting of Noxa1 is not sufficient for activation of Nox1. Both the Noxo1-independent and -dependent Nox1 systems involve Rac1, since they are affected by Rac1 mutants or Noxa1 mutants defective in Rac binding or short interfering RNA-mediated Rac1 silencing. Nox1 or Nox3 expression promotes p22phox transport to the plasma membrane, and both oxidases are inhibited by mutations in the p22phox binding sites (SH3 domains) of the Nox organizers (p47phox or Noxo1). Regulation of Nox3 by Rac1 was also evident from the effects of mutant Rac1 or mutant Nox3 activators (p67phox or Noxa1) or Rac1 silencing. In the absence of Nox organizers, the Nox activators (p67phox or Noxa1) colocalize with Rac1 within ruffling membranes, independently of their ability to bind Rac1. Thus, Rac1 regulates both oxidases through the Nox activators, although it does not appear to direct the subcellular localization of these activators.
Output: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Flumazenil (Ro 15-1788) proved to be a very efficacious competitive antagonist of benzodiazepines that reliably counteracts their pharmacological actions within 1-2 min as could be demonstrated in clinical and EEG studies. In general, a total dose of 0.3-0.8 mg will be sufficient in clinical practice, avoiding side effects like nausea, tremor, sweating, or transient anxiety that could be observed when higher dosages were administered. Its therapeutic range is very high as could be demonstrated in experimental animal in which up to 8.000-fold the clinical dose was administered. The total volume of distribution (Vdes) amounts to nearly 1.000 ml/kg BW and the total clearance exceeds 1.200 ml/min, resulting in a biological half-life of less than 60 min. According to the benzodiazepine dosage and the rapid plasma concentration decline of flumazenil, in some cases a resedation could be observed. Hence, a careful observation of the antagonised patient on the ward is mandatory for 1.5-2 h, even if at first sight the antagonization seemed successful and the patient fully awake and cooperative. In anaesthesia, indications to administer flumazenil are adverse drug reactions and prolonged recovery after adequate benzodiazepine dosage. In intensive care medicine, the antagonist may be used in the treatment of benzodiazepine overdose as well as in the differential diagnosis of a coma of unknown origin. Additionally, the antagonist may be administered to interrupt benzodiazepine sedation e.g. for neurological examination.
Output: Which drug should be used as an antidote in benzodiazepine overdose?
Individuals with Mowat-Wilson syndrome (MWS; OMIM#235730) have characteristic facial features, a variety of congenital anomalies such as Hirschsprung disease, and intellectual disabilities caused by mutation or deletion of ZEB2 gene. This deletion or cytogenetic abnormality has been reported primarily from Europe, Australia and the United States, but not in Korea. Here we report a patient with characteristic facial features of MWS, developmental delay and spasticity. High resolution microarray analysis revealed 0.9 Mb deletion of 2q22.3 involving two genes: ZEB2 and GTDC1. This case shows the important role of high resolution microarray in patients with unexplained psychomotor retardation and/or facial dysmorphism. Knowledge about the most striking clinical signs and implementation of effective molecular tests like microarray could significantly increase the detection rate of new cases of MWS in Korea. This is the first reported case of MWS in Korea.
Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Gene Leedy attended the University of Florida where he studied architecture.
Output: Where did Gene Leedy study or work?
The Volvo B12M is an underfloor-engined bus/coach chassis introduced by Volvo Buses in 2001 as a replacement for the Volvo B10M.
Output: What year was Volvo B12M commissioned?
Dorsum Owen is a wrinkle ridge at 25.0N 11.0E in Mare Serenitatis on the Moon.
Output: What is the astronomical body that Dorsum Owen is located on?
MicroRNAs (miRNAs) represent a family of small noncoding RNAs that are found in plants and animals (for recent reviews, see ). miRNAs are expressed in a developmentally and tissue-specific manner and regulate the translational efficiency and stability of partial or fully sequence-complementary mRNAs. miRNAs are excised in a stepwise process from double-stranded RNA precursors that are embedded in long RNA polymerase II primary transcripts (pri-miRNA). Drosha RNase III catalyzes the first excision event, the release in the nucleus of a hairpin RNA (pre-miRNA), which is followed by export of the pre-miRNA to the cytoplasm and further processing by Dicer to mature miRNAs. Here, we characterize the human DGCR8, the DiGeorge syndrome critical region gene 8, and its Drosophila melanogaster homolog. We provide biochemical and cell-based readouts to demonstrate the requirement of DGCR8 for the maturation of miRNA primary transcripts. RNAi knockdown experiments of fly and human DGCR8 resulted in accumulation of pri-miRNAs and reduction of pre-miRNAs and mature miRNAs. Our results suggest that DGCR8 and Drosha interact in human cells and reside in a functional pri-miRNA processing complex.
Output: Which polymerase transcribes pri-miRNAs?
Pad Thai, phat Thai or phad Thai (Thai: , rtgs: phat thai, ISO phadithy, pronounced (pat taj), ''fried Thai style'') is a stir-fried rice noodle dish commonly served as a street food and at casual local eateries in Thailand.
Output: The country for Pad Thai was what?
The Besbre is a river in central France, left tributary of the river Loire.
Output: Which river system contains Besbre?
On the basis of remarkable antitumor activity, programmed death receptor-1 (PD-1) inhibitors pembrolizumab and nivolumab were approved for the treatment of advanced melanoma in the second-line setting following progression on either CTLA-4 inhibitor ipilimumab or BRAF/MEK inhibitors (for BRAF mutated melanoma). Given hypothesized risk of triggering exacerbations of autoimmune diseases and/or chronic viral infections, clinical trials (including regulatory studies) evaluating checkpoint blocking antibodies PD-1 and CTLA-4 have excluded patients with autoimmune diseases, chronic hepatitis B/C virus (HBV/HCV), and/or human immunodeficiency virus (HIV) infections. Herein, we describe two patients with advanced melanoma and concomitant HCV/HIV infections treated with PD-1 inhibitor pembrolizumab. Patient 2 with HIV/HCV coinfection progressed after 2 doses of pembrolizumab. Patient 1 who had HCV alone was treated with pembrolizumab with initial partial response. HCV viral load remained stable after 9 cycles of pembrolizumab following which 12-week course of HCV-directed therapy was commenced, resulting in prompt reduction of HCV viral load below detectable levels. Response is ongoing and HCV viral load remains undetectable. In both patients, no significant toxicities were observed when pembrolizumab was initiated. We argue for the further investigation of checkpoint inhibition in cancer patients with underlying chronic viral infections in the context of carefully designed clinical trials.
Output: Which is the target protein of the drug nivolumab?
Venomm is a fictional character in the Marvel Universe, distinct from the half-alien fictional character known as Venom.
Output: With which fictional universe is the character Venomm associated?
Allele-specific gene silencing by RNA interference (RNAi) is therapeutically useful for specifically suppressing the expression of alleles associated with disease. To realize such allele-specific RNAi (ASPRNAi), the design and assessment of small interfering RNA (siRNA) duplexes conferring ASP-RNAi is vital, but is also difficult. Here, we show ASP-RNAi against the Swedish- and London-type amyloid precursor protein (APP) variants related to familial Alzheimer's disease using two reporter alleles encoding the Photinus and Renilla luciferase genes and carrying mutant and wild-type allelic sequences in their 3'-untranslated regions. We examined the effects of siRNA duplexes against the mutant alleles in allele-specific gene silencing and off-target silencing against the wild-type allele under heterozygous conditions, which were generated by cotransfecting the reporter alleles and siRNA duplexes into cultured human cells. Consistently, the siRNA duplexes determined to confer ASP-RNAi also inhibited the expression of the bona fide mutant APP and the production of either amyloid beta 40- or 42-peptide in Cos-7 cells expressing both the full-length Swedish- and wild-type APP alleles. The present data suggest that the system with reporter alleles may permit the preclinical assessment of siRNA duplexes conferring ASP-RNAi, and thus contribute to the design and selection of the most suitable of such siRNA duplexes.
Output: Which disease the London mutation involved in?
Tumors of the central nervous system are the most frequent solid tumors in childhood. With 30-40% of this heterogenous group, low-grade astrocytomas represent the most common subtype. Neurofibromatosis type 1 (NF1) is strongly associated with the development of pilocytic astrocytoma (PA), frequently appearing as optic glioma. Neurofibromatosis 1 gene (NF1 ) fulfills the criteria of a tumor suppressor gene and is deleted or mutated heterozygously in patients with NF1. This suggests an involvement in the development of PA. To clarify whether silencing of NF1 by promoter methylation plays a role in PA and especially in optic glioma, the authors investigated the methylation status in 30 PA, 6 of which had optic glioma. However, no methylation was found at the NF1 promoter region in PA. To rule out that silencing of NF1 by promoter methylation is restricted to higher-grade astrocytomas, 15 pediatric WHO II degree and IV degree astrocytomas were analyzed: 12 astrocytomas II and 3 glioblastomas displayed no NF1 promoter methylation. The authors conclude that NF1 silencing by methylation plays no role in low-grade astrocytoma.
Output: Which is the gene mutated in type 1 neurofibromatosis?
Newbury Academy was an alternative private high school serving students in grades 9-12 that opened in September 2001, based in Dumont, New Jersey.
Output: In which year the first version of Newbury Academy is released?
Extremaduran Popular Bloc (Spanish: Bloque Popular de Extremadura, BPEx) was a communist political coalition created in Extremadura in 1981 and dissolved in 1983.
Output: What year was the end of Extremaduran Popular Bloc?
Aggregation of -synuclein (Syn), the primary protein component in Lewy body inclusions of patients with Parkinson's disease, arises when the normally soluble intrinsically disordered protein converts to amyloid fibrils. In this work, we provide a mechanistic view of the role of N-terminal acetylation on fibrillation by first establishing a quantitative relationship between monomer secondary structural propensity and fibril assembly kinetics, and secondly by demonstrating in the N-terminal acetylated form of the early onset A53T mutation, that N-terminal transient helices formed and/or inhibited by N-terminal acetylation modulate the fibril assembly rates. Using NMR chemical shifts and fluorescence experiments, we report that secondary structural propensity in residues 5-8, 14-31, and 50-57 are highly correlated to fibril growth rate. A four-way comparison of secondary structure propensity and fibril growth rates of N-terminally acetylated A53T and WT Syn with non-acetylated A53T and WT Syn present novel mechanistic insight into the role of N-terminal acetylation in amyloid fibril formation. We show that N-terminal acetylation inhibits the formation of the "fibrillation promoting" transient helix at residues 14-31 resulting from the A53T mutation in the non-acetylated variant and supports the formation of the "fibrillation inhibiting" transient helix in residues 1-12 thereby resulting in slower fibrillation rates relative to the previously studied non-acetylated A53T variant. Our results highlight the critical interplay of the region-specific transient secondary structure of the N-terminal region with fibrillation, and the inhibitory role of the N-terminal acetyl group in fibril formation.
Output: Which is the primary protein component of Lewy bodies?
What's On? Trouble in Mind Alice Childress won an Off-Broadway award in 1956 for this story of a black actress rehearsing a play with a white director who increasingly finds it impossible for the show to go on. Tanya Moodie and Joseph Marcell star in the play directed by Laurence Boswell. 8.30p.m.--10.30p.m., Theatre Royal. Box office: 01225 448844. Lazarus Inspired by the sci-fi (science fiction) novel and movie,The Man Who Fell to Earth, this musical deals with a hero, Thomas Newton. Likely to be the autumn's hottest ticket, the score includes new songs composed by Bowie. 7.00p.m.--9.00p.m., King's Cross theatre. Box office: 0844 871 7604. The Gaul On the night of 8 February 1974, a fisherman FV Gaul disappeared off the coast of Norway. For people on board, waiting for news was great suffering. Theories began to come up, including the possibility that the boat had fallen victim to cold war. Even when he was discovered, many still felt there were questions that remained unanswered. Mark Babych directs Janet Plater's play. 8.00p.m.--11.00 p.m., Royal Shakespeare theatre. Box office: 01482 323638. The Suppliant Women It is a new version of Aeschylus's 2,500-year-old play about a group of women seeking shelter who make the long journey to escape forced marriage. It was written by David Greigand directed by Ramin Gray. An ancient piece asks a contemporary question: when we are introuble, who will open their doors and give us a harbor? 8.30p.m.--10.00p.m., Hampstead theatre. Box office: 0131 248 4848.
Output: Which number should you call if you want to watch a play between 8.00 p.m. and 10.00p.m.?
The Second Filat Cabinet was the Cabinet of Moldova from 14 January 2011 to 30 May 2013.
Output: What year did Second Filat Cabinet start?
The Battle of Adwa (also known as Adowa, or sometimes by the Italian name Adua) was fought on 1 March 1896 between the Ethiopian Empire and the Kingdom of Italy near the town of Adwa, Ethiopia, in Tigray.
Output: The point in time of Battle of Adwa was when?
Figure 1.1 shows the relative sizes of the orbits of the planets, asteroid belt, and Kuiper belt. In general, the farther away from the Sun, the greater the distance from one planets orbit to the next. The orbits of the planets are not circular but slightly elliptical, with the Sun located at one of the foci (see opening image). While studying the solar system, Johannes Kepler discovered the relationship between the time it takes a planet to make one complete orbit around the Sun, its "orbital period," and the distance from the Sun to the planet. If the orbital period of a planet is known, then it is possible to determine the planets distance from the Sun. This is how astronomers without modern telescopes could determine the distances to other planets within the solar system. How old are you on Earth? How old would you be if you lived on Jupiter? How many days is it until your birthday on Earth? How many days until your birthday if you lived on Saturn? Click image to the left or use the URL below. URL: The relative sizes of the orbits of planets in the solar system. The inner solar sys- tem and asteroid belt is on the upper left. The upper right shows the outer planets and the Kuiper belt.
Output: the time it takes a planet to make one complete orbit around the sun is known as its ____________.
Drowning Girl (also known as Secret Hearts or I Don't Care! I'd Rather Sink) is a 1963 painting in oil and synthetic polymer paint on canvas by Roy Lichtenstein.
Output: What material was used for Drowning Girl?
Breakfast with Hunter (2003) is a documentary about the everyday life of gonzo-journalist Hunter S. Thompson by Wayne Ewing.
Output: The Breakfast with Hunter is based upon what?
Sir John's considerable wealth in Barbados passed to his son, Major Sir William Yeamans, second baronet, and great-grandfather of Sir John Yeamans of Barbados, whose son, Sir Robert (d. 19 February 1788), was the last baronet.
Output: What was the title that John Yeamans held?
Mercedes & Sid Bass Donald C. Christ Agnes Gund George Gund III Graham Gund James R. Houghton James M. Jenness Ann Korologos Bibliography Nantucket Today, August 2008, Gordon Gund's Amazing Sculptures Inspired by Nature, by Elizabeth Stanek Atlantic Salmon Journal, Spring 2009, A Circle Unbroken by Donald Christ
Output: Which woman was the sister of Gordon Gund?
Specific outcomes upon activation of the c-Jun N-terminal kinase (JNK) pathway critically depend on the intensity and duration of signal transmission. Dual-specificity phosphatases (DUSPs) play a very important role in these events by modulating the extent of JNK phosphorylation and activation and thus regulating cellular responses to stress. M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK. It has been shown that M3/6 itself is phosphorylated by JNK upon stimulation with arsenite, but the role of this phosphorylation has not been investigated. In this study, we mapped JNK-induced phosphorylation sites on M3/6 using mass spectrometry. Phosphorylated residues Ser 515, Thr 518 and Ser 520 were identified and site-directed mutagenesis was employed to investigate their role. Upon arsenite stimulation, M3/6 mutated at these sites exhibited decreased phosphorylation compared to the wild-type protein. No difference was observed in terms of the enzyme's in vitro phosphatase activity, its substrate specificity towards JNK isoforms, its interactions with JNK and the scaffold family of JNK-interacting proteins (JIPs), its stability or its subcellular localization. Interestingly, expression of M3/6 phosphorylation mutants delayed the time-course of JNK phosphorylation and activation by arsenite. We propose that phosphorylation of the M3/6 phosphatase by JNK in response to stress stimuli results in attenuation of phosphatase activity and acceleration of JNK activation.
Output: Which protein is affected by dusp8 activation?
Chronic myelogenous leukemia (CML) results from the neoplastic transformation of primitive hematopoietic stem cells, and has been classified as a myeloproliferative disorder. The hallmark of CML is the presence of a balanced translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11.2), which is known as the Philadelphia (Ph) chromosome. This translocation results in the formation of the bcr-abl fusion gene, which, in turn, is translated into a chimeric Bcr-Abl protein with deregulated tyrosine kinase activity. Constitutive Bcr-Abl expression has been shown to be necessary and sufficient for the transformed phenotype of CML cells. CML is unique among human cancers in that a single genetic defect, the Ph chromosome, is responsible for the transformed phenotype. Since this discovery more than 40 years ago, our understanding of the clinical course, therapy, and prognosis of patients with CML has changed significantly. These changes have culminated in the emergence of imatinib, the first rationally designed, molecularly targeted therapy for human malignancy. In this review, the authors describe the molecular biology of CML and the development of imatinib as a therapeutic agent for the treatment of CML.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
MicroRNAs (miRNAs) play a major part in the post-transcriptional regulation of gene expression. Mammalian miRNA biogenesis begins with cotranscriptional cleavage of RNA polymerase II (Pol II) transcripts by the Microprocessor complex. Although most miRNAs are located within introns of protein-coding transcripts, a substantial minority of miRNAs originate from long noncoding (lnc) RNAs, for which transcript processing is largely uncharacterized. We show, by detailed characterization of liver-specific lnc-pri-miR-122 and genome-wide analysis in human cell lines, that most lncRNA transcripts containing miRNAs (lnc-pri-miRNAs) do not use the canonical cleavage-and-polyadenylation pathway but instead use Microprocessor cleavage to terminate transcription. Microprocessor inactivation leads to extensive transcriptional readthrough of lnc-pri-miRNA and transcriptional interference with downstream genes. Consequently we define a new RNase III-mediated, polyadenylation-independent mechanism of Pol II transcription termination in mammalian cells.
Output: Which polymerase transcribes pri-miRNAs?
Cymbastela is a genus of sponges in the family Axinellidae.
Output: Is the taxon rank of Cymbastela species or genus?
Henry Fevrier was the father of the pianist Jacques Fevrier.
Output: Who is the offspring of Henry Février?
Cells respond to stresses such as osmotic shock and heat shock by activating stress-activated protein kinases (SAPKs), including c-Jun N-terminal kinase (JNK) [1]. Activation of JNK requires phosphorylation of threonine and tyrosine residues in the TPY activation loop motif [2, 3] and can be reversed by the removal of either phosphate group. Numerous JNK phosphatases including dual-specificity phosphatases [4, 5], have been identified. Many stimuli activate JNK by increasing its rate of phosphorylation; however, JNK dephosphorylation is inhibited in cells after heat shock [6], suggesting that a JNK phosphatase(s) is inactivated. M3/6 is a dual-specificity phosphatase selective for JNK [7, 8]. We have previously expressed M3/6 in the mouse bone marrow cell line BAF3 in order to show that JNK activation by IL-3 is necessary for cell survival and proliferation [9]. Here we report that M3/6 dissociates from JNK and appears in an insoluble fraction after heat shock. These data identify M3/6 as a JNK phosphatase that is inactivated by heat shock and provide a molecular mechanism for the activation of JNK by heat shock.
Output: Which protein is affected by dusp8 activation?
The Canon de 75 mle TR was a field gun used by Belgium during World War I and World War II. It was a license-built copy of the Krupp M 1905 gun.
Output: What year was Canon de 75 mle TR made?
Elena Wexler-Kreindler (15 October 1931 -- August 2002) was a Romanian mathematician.
Output: The date of birth of Eléna Wexler-Kreindler is?
HD 79447, also known as i Carinae (i Car) is a star in the constellation Carina.
Output: What constellation is HD 79447 part of?
CHEK2 is located on the long (q) arm of chromosome 22.
Output: Which chromosome is CHEK2 associated with?
The Chinese version of the Davidson Trauma Scale (DTS-C) was developed to respond to the need of Chinese-speaking individuals. The DTS is a validated self-rating scale used in the diagnosis of posttraumatic stress disorder (PTSD). The DTS-C is translated from DTS through a two-stage translation. Subjects were drawn from a sample of 210 survivors of the 21 September 1999, Chi-Chi Earthquake. The scale showed good internal consistency (Cronbach's alpha = 0.97) and test-retest reliability (r = 0.88). Concurrent validity was obtained against the clinical diagnostic interview, with a diagnostic accuracy of 0.85 at DTS-C score of 44. It showed that the sensitivity was 0.9, specificity 0.81, positive likelihood ratio 4.74, and negative likelihood ratio 0.12. The recommended stratum-specific likelihood ratios were 0.10 (95% CI: 0.05-0.20) for the score range 0-39, 4 (2.22-7.23) for the score range of 40-59, and 6.14 (3.42-11.02) for the scores above 60. In PTSD diagnosed subjects, the factor structures closely resembled the DSM-IV grouping of PTSD symptoms. The psychometric strength of DTS-C is reliable for its future use, particularly for screening for subjects with possible diagnosis of PTSD.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
Marie Louis Adolphe Guillaumat (January 4, 1863 -- Nantes, May 18, 1940) was a French Army general during World War I.
Output: Where did Adolphe Guillaumat live when he died?
Varjoina kuljemme kuolleiden maassa (''As Shadows We Walk in the Land of the Dead'') is the sixth full-length album by Finnish pagan metal band Moonsorrow.
Output: Who created Varjoina kuljemme kuolleiden maassa?
This has never been established as there are no witnesses to any verbal exchange and Susan Newell never pleaded guilty (first blaming her husband then citing insanity without giving details into the murder.)
Output: Which crime led to the conviction of Susan Newell?
It was believed that Myoma Nyein committed suicide in 1955, aged 46, by walking in front of a lorry.
Output: In one word, how did Myoma Nyein die?
Language Matters with Bob Holman is a 2015 documentary which focuses upon the rapid extinction of many of planet Earth's human languages and the multifarious struggles and efforts to save and preserve them.
Output: In what year was Language Matters with Bob Holman created?
Ehlers-Danlos syndrome is a heterogeneous group of heritable connective tissue disorders characterized by increased fragility of various non-ossified tissues. It is usually ascertained due to abnormal skin texture, scarring complications, vascular fragility, or chronic symptoms, such as fatigue and musculoskeletal pain. Sometimes, Ehlers-Danlos syndrome remains undetected until the patient, usually in the pediatric age, shows extensive or severe mucocutaneous injuries after only minor traumas. In this scenario, the misdiagnosis of Ehlers-Danlos syndrome with child abuse is a possibility, as occasionally reported in the literature. Recently, more attention was posed by lay people between the possible association of Ehlers-Danlos syndrome and bone fragility. Literature and personal experience show a strong association between Ehlers-Danlos syndrome, generalized joint hypermobility and reduced bone mass density in older children and adults, especially fertile women. The existence of a true increased risk of fracture in Ehlers-Danlos syndrome is still a matter of debate in children and adults with little and conflicting evidence. In case of suspected child abuse, Ehlers-Danlos syndrome is certainly on the differential for bruising, especially in EDS types with marked cutaneous and capillary involvement. In suspected child abuse cases, careful examination of the index case and her/his extended family is routine, as well as exclusion of other disorders such as osteogenesis imperfecta. The hypothesis of Ehlers-Danlos syndrome as an alternative explanation for infantile fractures remains speculative.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
Leonardo Ghiraldini (born 26 December 1984 in Padua) is an Italian rugby union player for Leicester Tigers in the Aviva Premiership.
Output: Which team does Leonardo Ghiraldini play for?
Mutations in FOXP2 cause developmental verbal dyspraxia (DVD), but only a few cases have been described. We characterize 13 patients with DVD--5 with hemizygous paternal deletions spanning the FOXP2 gene, 1 with a translocation interrupting FOXP2, and the remaining 7 with maternal uniparental disomy of chromosome 7 (UPD7), who were also given a diagnosis of Silver-Russell Syndrome (SRS). Of these individuals with DVD, all 12 for whom parental DNA was available showed absence of a paternal copy of FOXP2. Five other individuals with deletions of paternally inherited FOXP2 but with incomplete clinical information or phenotypes too complex to properly assess are also described. Four of the patients with DVD also meet criteria for autism spectrum disorder. Individuals with paternal UPD7 or with partial maternal UPD7 or deletion starting downstream of FOXP2 do not have DVD. Using quantitative real-time polymerase chain reaction, we show the maternally inherited FOXP2 to be comparatively underexpressed. Our results indicate that absence of paternal FOXP2 is the cause of DVD in patients with SRS with maternal UPD7. The data also point to a role for differential parent-of-origin expression of FOXP2 in human speech development.
Output: Which gene is responsible for proper speech development?
L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-l-alanine (l-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact from unilateral 6-hydroxydopamine lesions and l-DOPA (4 mg/kg, including benserazide 15 mg/kg) -induced dyskinetic behavior on striatal basal extracellular glutamate concentration and potassium-evoked glutamate release in urethane-anesthetized rats. Recordings were performed before and after local L-DOPA application in the striatum. In addition, effects from the 5-HT(1A) receptor agonist (2R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OHDPAT; 1 mg/kg) was assessed on glutamate release and on dyskinetic behavior. The results revealed a bilateral 30% reduction of basal extracellular glutamate concentration and attenuated potassium-evoked glutamate release after a unilateral dopamine-depletion in L-DOPA naive animals. In dyskinetic subjects, basal glutamate concentration was comparable to normal controls, although potassium-evoked glutamate release was reduced to similar levels as in drug naive dopamine-lesioned animals. Furthermore, acute striatal L-DOPA administration attenuated glutamate release in all groups, except in the dopamine-lesioned striatum of dyskinetic animals. Co-administration of 8-OHDPAT and L-DOPA decreased dyskinesia in dopamine-lesioned animals, but did not affect potassium-evoked glutamate release, which was seen in normal animals. These findings indicate altered glutamate transmission upon dopamine-depletion and dyskinesia.
Output: Which drug is benserazide usually co-administered with?
There are records of fingerprints taken many centuries ago. The ancient Babylonians pressed the tips of their fingerprints into clay to record business trade. The Chinese used ink-on-paper finger impressions for business. However, fingerprinting wasn't used as a method for identifying criminals until the 19th century. In 1858, Sir William Herschel was working as an official of the Hooghly district in Jungipoor, India.In order to reduce fraud , he had people living in the district record their fingerprints when signing business documents. A few years later, Scottish doctor Henry Faulds was working in Japan when he discovered fingerprints left by artists on ancient pieces of clay.This finding inspired him to begin investigating fingerprints.In 1880, Faulds wrote to his cousin, the famous naturalist Charles Darwin, and asked for help with developing a fingerprint classification system.Darwin refused, but sent the letter to his cousin, Sir Francis Gallon, who was an eugenicist . Gallon began collecting fingerprints and eventually gathered some 8, 000 different samples to analyze. In 1892, he published a book called "Fingerprints", in which he outlined a fingerprint classification system--the first existence. Around the same time, Juan Vucetich, a police officer in Buenos Aires, Argentina, was developing his own version of a fingerprinting system.In 1892, Vucetich was called in to assist with the investigation of the two boys murdered in Necoche, a village near Buenos Aires. Their mother, Francisca Rojas, accused a neighbour named Velasquez. But when Vucetich compared the fingerprints found at the murder scene to those of both Velasquez and Rojas, _ matched Rojas' exactly.She admitted her crime. This was the first time fingerprints had been used in a criminal investigation.Vucetich called his system comparative dactyloscopy . It's still used in many Spanish-speaking countries. Sir Edward Henry, in charge of the Metropolitan Police of London, soon became interested in using fingerprints to catch criminals. In 1896, he added to Gallon's technique, creating his own classification system, the Henry Classification System. It is the primary method of fingerprint classification throughout most of the world.
Output: Who first came up with the idea of creating a fingerprint classification system?