niryuu/sni-each-converted huggingface dataset:
The Browns traveled to Indianapolis to take on an Andrew Luck-led Colts offense. The Colts were able to score in the first quarter as Andrew Luck ran for a 3-yard touchdown making the score 7-0 for the only score of the game. The Browns responded in the 2nd quarter coming within a point when Brandon Weeden found Greg Little on a 14-yard pass (with a failed PAT) making the score 7-6. Then, Luck ran for another touchdown this time from 5 yards out to make the score 14-6 at halftime. The Browns came within a point again in the 3rd quarter as Weeden found Josh Gordon on a 33-yard pass making the score 14-13 but the Colts wrapped things up with Adam Vinatieri's 38-yard field goal followed by a scoreless 4th quarter making the final score 17-13 as the Browns' road record at this point of the season was 0-4 while their record overall was 1-6.
Output: Which team scored more points in the first half?
He was the son of The 4th Earl of Clanricarde by his wife Frances Walsingham. Ulick's father was from an Anglo-Norman family who had been long settled in the west of Ireland and had become Gaelicised. Although during the early sixteenth century the family had rebelled against the Crown on several occasions, Ulick's father had been a strong supporter of Queen Elizabeth I. He fought on the Queen's side during Tyrone's Rebellion, notably during the victory at the Battle of Kinsale, where he was wounded. After the war he married the widow of The 2nd Earl of Essex, a recent commander in Ireland, who was the daughter of the English Secretary of State and spymaster Sir Francis Walsingham. In 1622, Ulick married his only wife Anne Compton, the daughter of The 1st Earl of Northampton and his wife, Elizabeth Spencer. They had a single child, Margaret Burgh, who married Viscount Muskerry. Ulick was summoned to the House of Lords as Lord Burgh in 1628, and succeeded his father as 5th Earl of Clanricarde in 1635. In 1636, he inherited Somerhill House on the death of his father. He was a staunch opponent of the policies of the Lord Deputy of Ireland, The 1st Earl of Strafford, who had attempted to seize much of the great Burke inheritance for the Crown; there was also personal ill-feeling between the two men since the dispute was thought by many to have hastened the death of Ulick's elderly father. He sat in the Short Parliament of 1640 and attended King Charles I in the Scottish expedition. Charles, unlike Strafford, liked and trusted Lord Clanricarde.
Output: When did Ulick marry the widow of the 2nd Earl of Essex?
The amino acid selenocysteine is encoded by UGA, usually a stop codon, thus requiring a specialized machinery to enable its incorporation into selenoproteins. The machinery comprises the tRNA(Sec), a 3'-UTR mRNA stem-loop termed SElenoCysteine Insertion Sequence (SECIS), which is mandatory for recoding UGA as a Sec codon, the SECIS Binding Protein 2 (SBP2), and other proteins. Little is known about the molecular mechanism and, in particular, when, where, and how the SECIS and SBP2 contact the ribosome. Previous work by others used the isolated SECIS RNA to address this question. Here, we developed a novel approach using instead engineered minimal selenoprotein mRNAs containing SECIS elements derivatized with photoreactive groups. By cross-linking experiments in rabbit reticulocyte lysate, new information could be gained about the SBP2 and SECIS contacts with components of the translation machinery at various translation steps. In particular, we found that SBP2 was bound only to the SECIS in 48S pre-initiation and 80S pretranslocation complexes. In the complex where the Sec-tRNA(Sec) was accommodated to the A site but transpeptidation was blocked, SBP2 bound the ribosome and possibly the SECIS element as well, and the SECIS had flexible contacts with the 60S ribosomal subunit involving several ribosomal proteins. Altogether, our findings led to broadening our understanding about the unique mechanism of selenocysteine incorporation in mammals.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Young Man with a Skull is a painting by the Dutch Golden Age painter Frans Hals, painted in 1626 and now in the National Gallery, London.
Output: What is the name of the place where Young Man with a Skull can be found?
Transcription-coupled repair (TCR) is a sub-pathway of nucleotide excision repair that allows for the enhanced repair of the transcribed strand of active genes. A classical method to study DNA repair in vivo consists in the molecular analysis of UV-induced DNA damages at specific loci. Cells are irradiated with a defined dose of UV light leading to the formation of DNA lesions and incubated in the dark to allow repair. About 90% of the photoproducts consist of cyclobutane pyrimidine dimers, which can be cleaved by the DNA nicking activity of the T4 endonuclease V (T4endoV) repair enzyme. Strand-specific repair in a suitable restriction fragment is determined by alkaline gel electrophoresis followed by Southern blot transfer and indirect end-labeling using a single-stranded probe. Recent approaches have assessed the role of transcription factors in TCR by analyzing RNA polymerase II occupancy on a damaged template by chromatin immunoprecipitation (ChIP). Cells are treated with formaldehyde in vivo to cross-link proteins to DNA and enrichment of a protein of interest is done by subsequent immunoprecipitation. Upon reversal of the protein-DNA cross-links, the amount of coprecipitated DNA fragments can be detected by quantitative PCR. To perform ChIP on UV-damaged templates, we included an in vitro photoreactivation step prior to PCR analysis to ensure that all precipitated DNA fragments serve as substrates for the PCR reaction. Here, we provide a detailed protocol for both the DNA repair analysis and the ChIP approaches to study TCR in chromatin.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
In the published version of The Silmarillion, Orodreth (IPA: (orodre)) was an Elf of the First Age, the second son of Finarfin (with Finrod Felagund, Angrod, Aegnor, and Galadriel being his siblings), and a ruler of Nargothrond.
Output: Who is Orodreth's sister?
Ass Ponys was an indie rock band based in Cincinnati, Ohio.
Output: What city was Ass Ponys formed in?
Turner's syndrome, also known as 'monosomy X', is a genetic disorder that occurs in 1/2,500 female births and is hypothesized to result from haploinsufficiency of certain genes expressed from both sex chromosomes that escape X inactivation. While the classic karyotype related to Turner's syndrome is 45,X, the majority of those affected actually have a mosaic chromosomal complement, most often with a second normal cell line (46,XX). The resulting phenotype is variable and related to the underlying chromosomal pattern, but it is characterized by three cardinal features: short stature (around 100%), ovarian failure (>90%) and congenital lymphedema (>80%). In this paper we report a molecular and cytogenetic investigation of a 26-year-old female with non-mosaic 45,X karyotype, who has a stature of 170 cm without GH treatment, and whose only apparent Turner feature is gonadal dysgenesis. The only possible explanation for the absence of Turner phenotype is the hidden mosaicism combined with an untreated gonadal dysgenesis. Our results support the theory that significant ascertainment bias exists in our understanding of Turner's syndrome.
Output: What chromosome is affected in Turner's syndrome?
Naive and primed pluripotent states retain distinct molecular properties, yet limited knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency. Mettl3 knockout preimplantation epiblasts and naive embryonic stem cells are depleted for m(6)A in mRNAs, yet are viable. However, they fail to adequately terminate their naive state and, subsequently, undergo aberrant and restricted lineage priming at the postimplantation stage, which leads to early embryonic lethality. m(6)A predominantly and directly reduces mRNA stability, including that of key naive pluripotency-promoting transcripts. This study highlights a critical role for an mRNA epigenetic modification in vivo and identifies regulatory modules that functionally influence naive and primed pluripotency in an opposing manner.
Output: Which properties of the mRNA does N6-methyladenosine (m6A) affect?
Restless legs syndrome (RLS) is a common condition that is frequently unrecognized, misdiagnosed and poorly managed. It is characterized by uncomfortable sensations deep in the legs developing at rest that compel the person to move; symptoms are worst at night and sleep disturbance is common. RLS occurs in 7%-11% of the population in Western countries, and many such people experience troublesome symptoms. Primary RLS is familial in up to two thirds of patients. RLS may also be secondary to a number of conditions including iron deficiency, pregnancy and end-stage renal failure and, perhaps, neuropathy. Secondary RLS is most common in those presenting for the first time in later life. The pathogenesis of RLS probably involves the interplay of systemic or brain iron deficiency and impaired dopaminergic neurotransmission in the subcortex of the brain. RLS is very responsive to dopaminergic therapies. Rebound of RLS symptoms during the early morning and development of severe symptoms earlier in the day (augmentation) are problematic in those treated for a prolonged period with levodopa. Consequently, dopamine agonists have become first line treatment. Anti-convulsant medications and opioids are helpful in some patients. Correction of underlying problem wherever possible is important in the management of secondary RLS.
Output: Which deficiency is the cause of restless leg syndrome?
Using tablet computers like Apple's iPad and Samsung's Galaxy Note just before bed can lead to a poor night's sleep, according to research. More and more people are taking their tablets to bed with them to surf the web, check Facebook or email before switching off the light. But researchers are warning that the blueish light their screens emit can stop users getting a good night's sleep. That is because this type of light mimics daylight, convincing the brain that it is still daytime. Blue light suppresses production of a brain chemical called melatonin, which helps us fall sleep. This is because our brains have evolved to be wakeful during daylight hours. By contrast, light which is more orange or red in tone does not reduce melatonin production, perhaps because our brains recognize it as a cue that the day is ending. Neurologists have known for years that staring at screens late in the evening can disrupt sleep. Researchers at the Lighting Research Centre, at the Rensselaer Polytechnic Institute in New York, are warning that looking at tablet displays for more than two hours "leads to a suppression of our natural melatonin levels as the devices emit optical radiation at short wavelengths" - in other words, they emit bluer light. They say: "Although turning off devices at night is the ultimate solution, it is recommended that if these devices are used at night displays are dimmed as much as possible and that the time spent on them before bed should be limited." They drew their conclusions after measuring melatonin levels in 13 volunteers, after they had spent time viewing iPads at full brightness at a distance of 10 inches, for two hours. Melatonin levels were significantly lower after they had done this, than they were after the volunteers had viewed their iPads for the same time, but while wearing orange glass goggles, which cut out the blue light. They wrote in the journal Applied Ergonomics that tablet makers could "tune the spectral power distribution of self-luminous devices " so that they disrupted the sleep patterns of users less. It is not just a good night's sleep that could be jeopardized by too much late night screen time. Researchers know that persistent disruption to sleep patterns can lead to an increased risk of obesity, and even breast cancer. However, these studies tend to be comparisons of those with chronic sleep disruption, such as long term shift workers, with those who have normal sleep patterns.
Output: What is it that stops users getting a good night's sleep?
The human ETHE1 gene consists of 7 exons and encodes for a protein that is approximately 27 kDa in size.
Output: Which species has the ETHE1 gene?
Sir John Hoskyns, 2nd Baronet PRS (23 July 1634 -- 12 September 1705) was an English baronet.
Output: What was the title that Sir John Hoskyns, 2nd Baronet held?
To determine the change in prevalence of posttraumatic stress disorder (PTSD) symptoms in victims of the March 11 attacks and their relatives, 1 and 6 months after the attacks. Evaluation of PTSD symptoms using the Davidson Trauma Scale (DTS) and General Health Questionnaire (GHQ) in a sample of 56 patients admitted to an emergency room of a general hospital, and assessment of PTSD symptoms in relatives of the patients. At Month 1, 41.1% of patients (31.3% of males and 54.2% of females) presented with PTSD. At Month 6, this figure was 40.9% (30.4% of males and 52.4% of females). There was a significant improvement in perception of health among females between Month 1 and Month 6. Relatives presented similar DTS scores at baseline and at 6 months. We verified that rates of PTSD did not vary substantively between the two evaluations. PTSD symptoms positively correlated with psychological health involvement. This correlation points out that both PTSD symptoms and subjective general health involvement are part of the psychological response to trauma. The prevalence of PTSD symptoms was high and remained stable between Month 1 and Month 6, while subjective perception of health improved significantly.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
Toby Robins died from breast cancer in 1986, one week after her 55th birthday.
Output: What disease did Toby Robins have?
Such Friends Are Dangerous is the second and final studio album by American punk rock band Excuse 17, released on April 24, 1995 by Kill Rock Stars.
Output: Which was the record label for Such Friends Are Dangerous?
Can you name some fossils? How about dinosaur bones or dinosaur footprints? Animal skeletons, teeth, shells, coprolites (otherwise known as feces), or any other remains or traces from a living creature that becomes rock is a fossil. The same processes that formed these fossils also created some of our most important energy resources, fossil fuels. Coal, oil, and natural gas are fossil fuels. Fossil fuels come from living matter starting about 500 million years ago. Millions of years ago, plants used energy from the Sun to form sugars, carbohydrates, and other energy-rich carbon compounds. As plants and animals died, their remains settled on the ground on land and in swamps, lakes, and seas (Figure 1.1). Over time, layer upon layer of these remains accumulated. Eventually, the layers were buried so deeply that they were crushed by an enormous mass of earth. The weight of this earth pressing down on these plant and animal remains created intense heat and pressure. After millions of years of heat and pressure, the material in these layers turned into chemicals called hydrocarbons (Figure 1.2). Hydrocarbons are made of carbon and hydrogen atoms. This molecule with one carbon and four hydrogen atoms is methane. Hydrocarbons can be solid, liquid, or gaseous. The solid form is what we know as coal. The liquid form is petroleum, or crude oil. Natural gas is the gaseous form. The solar energy stored in fossil fuels is a rich source of energy. Although fossil fuels provide very high quality energy, they are non-renewable. Click image to the left or use the URL below. URL:
Output: hydrocarbons in gas form are called __________________.
Hoping to rebound from their three-game losing streak, the Raiders flew to Dolphin Stadium for a Week 11 duel with the Miami Dolphins. In the first quarter, Oakland trailed early as Dolphins WR Ted Ginn, Jr. got a 40-yard TD run. In the second quarter, the Raiders responded with kicker Sebastian Janikowski getting a 21-yard field goal. In the third quarter, Oakland started to catch up as DE Jay Richardson sacked QB Chad Pennington in his own endzone for a safety. Miami would answer with RB Patrick Cobbs getting a 10-yard TD run. In the fourth quarter, the Raiders took the lead as Janikowski got a 37-yard field goal, along with WR Johnnie Lee Higgins returning a punt 93 yards for a touchdown. However, the Dolphins sealed Oakland's fate as kicker Dan Carpenter nailed a 38-yard field goal.
Output: Which player scored a safety?
High circulating levels of group IIA secretory phospholipase A2 (sPLA2-IIA) activity and mass are independent cardiovascular risk factors. Therefore, inhibition of sPLA2-IIA may be a target for the treatment of atherosclerotic cardiovascular disease. The present study evaluated the effects of sPLA2-IIA inhibition with varespladib acid in a novel mouse model, human apolipoprotein B (apoB)/human cholesteryl ester transfer protein (CETP)/human sPLA2-IIA triple transgenic mice (TTT) fed a Western-type diet. sPLA2-IIA expression increased atherosclerotic lesion formation in TTT compared with human apoB/human CETP double transgenic mice (P<0.01). Varespladib acid effectively inhibited plasma sPLA2-IIA activity. Surprisingly, however, administration of varespladib acid to TTT had no impact on atherosclerosis, which could be attributed to a proatherogenic plasma lipoprotein profile that appears in response to sPLA2-IIA inhibition because of increased plasma CETP activity. In the TTT model, sPLA2-IIA decreased CETP activity by reducing the acceptor properties of sPLA2-IIA-modified very low-density lipoproteins specifically because of a significantly lower apoE content. Increasing very low-density lipoprotein-apoE content by means of adenovirus-mediated gene transfer in sPLA2-IIA transgenic mice restored the acceptor properties for CETP. These data show that in a humanized triple transgenic mouse model with hypercholesterolemia, sPLA2-IIA inhibition increases CETP activity via increasing the very low-density lipoprotein-apoE content, resulting in a proatherogenic lipoprotein profile.
Output: Which enzyme is inhibited by Varespladib?
The Naches River is a tributary of the Yakima River in central Washington in the United States.
Output: What river is Naches River a tributary of?
Temperature is a measure of how fast the atoms in a material are vibrating. High temperature particles vibrate faster than low temperature particles. Rapidly vibrating atoms smash together, which generates heat. As a material cools down, the atoms vibrate more slowly and collide less frequently. As a result, they emit less heat. What is the difference between heat and temperature? Temperature measures how fast a materials atoms are vibrating. Heat measures the materials total energy. Heat energy is transferred between physical entities. Heat is taken in or released when an object changes state, or changes from a gas to a liquid, or a liquid to a solid. This heat is called latent heat. When a substance changes state, latent heat is released or absorbed. A substance that is changing its state of matter does not change temperature. All of the energy that is released or absorbed goes toward changing the materials state. For example, imagine a pot of boiling water on a stove burner: that water is at 100o C (212o F). If you increase the temperature of the burner, more heat enters the water. The water remains at its boiling temperature, but the additional energy goes into changing the water from liquid to gas. With more heat the water evaporates more rapidly. When water changes from a liquid to a gas it takes in heat. Since evaporation takes in heat, this is called evaporative cooling. Evaporative cooling is an inexpensive way to cool homes in hot, dry areas. Substances also differ in their specific heat, the amount of energy needed to raise the temperature of one gram of the material by 1.0o C (1.8o F). Water has a very high specific heat, which means it takes a lot of energy to change the temperature of water. Lets compare a puddle and asphalt, for example. If you are walking barefoot on a sunny day, which would you rather walk across, the shallow puddle or an asphalt parking lot? Because of its high specific heat, the water stays cooler than the asphalt, even though it receives the same amount of solar radiation.
Output: the amount of energy needed to raise the temperature of one gram of material by 1.0oc.
Edeline Lee was born and raised in Vancouver, BC, Canada and completed a Bachelor of Arts degree with First Class Joint Honors at McGill University in 1999.
Output: Which college or university is related with Edeline Lee?
Georgi Bizhev (Bulgarian: ) (born 6 July 1981 in Blagoevgrad) is a Bulgarian footballer who plays for Spartak Varna as a forward.
Output: What is the football position of Georgi Bizhev?
The translocation (9;22) gives rise to the p190(Bcr-Abl) and p210(Bcr-Abl) tyrosine kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive (Ph(+)) acute leukemia patients failing to respond to initial induction therapy have a poor prognosis with few effective treatment options. Imatinib is an orally administered, potent inhibitor of the Bcr-Abl tyrosine kinase. We conducted a clinical trial in 56 patients with relapsed or refractory Ph(+) acute lymphoblastic leukemia (ALL; 48 patients) or chronic myelogenous leukemia in lymphoid blast crisis (LyBC; 8 patients). Imatinib was given once daily at 400 mg or 600 mg. Imatinib induced complete hematologic responses (CHRs) and complete marrow responses (marrow-CRs) in 29% of ALL patients (CHR, 19%; marrow-CR, 10%), which were sustained for at least 4 weeks in 6% of patients. Median estimated time to progression and overall survival for ALL patients were 2.2 and 4.9 months, respectively. CHRs were reported for 3 (38%) of the patients with LyBC (one sustained CHR). Grade 3 or 4 treatment-related nonhematologic toxicity was reported for 9% of patients; none of the patients discontinued therapy because of nonhematologic adverse reactions. Grade 4 neutropenia and thrombocytopenia occurred in 54% and 27% of patients, respectively. Imatinib therapy resulted in a clinically relevant hematologic response rate in relapsed or refractory Ph(+) acute lymphoid leukemia patients, but development of resistance and subsequent disease progression were rapid. Further studies are warranted to test the effects of imatinib in combination with other agents and to define the mechanisms of resistance to imatinib.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Cambridge University Botanic Garden We run a lively programme of family events, life-long learning courses and much more throughout the year. Improve your Digital Photography This course led by award-winning photographer, Pete Murray, will show you how to take control of your camera. Using a proven "step by step approach" you will gain confidence in using your camera. Date:29/09 Time:10 am--4 pm Price:PS60 Event Category: Garden Photography 'Handbag' Baskets New to the Botanic Garden, this course will give you the opportunity to make your very own beautiful 'handbag basket'from a design that local basketry maker, Debbie Hall, developed herself. They have proved very popular since she started teaching the technique. Date: 07/10 Time: 10 am --4:30 pm Price: PS120 Event Category: Weaving & Basketry Trees and Shrubs for Autumn Color Join Mark Crouch, a specialist in the care of trees, for this course on choosing trees and shrubs to create beautiful autumn displays for your garden. The day will include a talk in our classroom and a tour of the Botanic Garden to look at autumn color and interest across our tree and shrub collection. Date: 17/10 Time: 10 am --4 pm Price: PS50 Event Category: Gardens and Plants Introduction to Botanical Subjects in Colored Pencil If you are interested in beginning to use colored pencils to draw botanical subjects, then this is the course for you. Janie Pirie is one of the country's leading pencil artists and on this one-day course she will show you the basic techniques used when working with colored pencils. Date: 16/10 Time: 10 am --4 pm Price: PS40 Event Category: Botanical Art
Output: How much would you pay if you wanted to learn to take better pictures?
But before the close of the war (about 250 BCE), when the Carthaginians were beginning to contract their operations, and confine themselves to the defense of as few points as possible, they removed all the inhabitants of Selinunte to Lilybaeum and destroyed the city It seems certain that it was never rebuilt.
Output: What year did Selinunte dissolve?
Many studies have reported that the generation of reactive oxygen species (ROS) increases during the differentiation of muscle-derived C2C12 cells. Peroxiredoxin-2 (Prx-2) is an abundant mammalian enzyme that protects against oxidative stress. However, the role of Prx-2 in muscle differentiation has not been investigated. In this study, we demonstrated that Prx-2 expression increases during muscle differentiation and regeneration in response to exogenous H(2)O(2). This increase occurs only in myoblast cell lines because no increase in Prx-2 expression was observed in the NIH3T3, MEF, Chang, or HEK293 cell lines. The antioxidants, N-acetyl L-cysteine (NAC) and 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), both suppressed myogenesis and Prx-2 expression. Moreover, Prx-2 was upregulated at the transcriptional level by NF-B during the differentiation of muscle-derived C2C12 cells. We also found that inhibition of phosphatidylinositol 3-kinase (PI3K) blocks NF-B activation and suppresses Prx-2 expression. Interestingly, Prx-2 knockdown increased the expression levels of other antioxidant enzymes, including all of the other Prx family member, thioredoxin-1 (Trx-1) and catalase, but also enhanced the accumulation of endogenous ROS during muscle differentiation. In this study, we demonstrated for the first time that Prx-2 is unregulated during the muscle differentiation and regeneration. Prx-2 is upregulated via the PI3K/NF-B pathway and attenuates oxidative stress during muscle differentiation and regeneration.
Output: What type of enzyme is peroxiredoxin 2 (PRDX2)?
To summarize the use of tyrosine kinase inhibitors (TKIs) for treatment of patients with chronic myeloid leukemia (CML) and provide practical information for patient management. Literature was retrieved from PubMed (2000-January 2011), using the search terms chronic myeloid leukemia and tyrosine kinase inhibitor. Abstracts presented at the 2008-2010 annual meetings of the American Society of Hematology and the American Society of Clinical Oncology, reference citations from identified publications, as well as the manufacturers' full prescribing information for cited drugs, also were reviewed. Articles evaluating the efficacy and safety of the TKIs imatinib, nilotinib, and dasatinib were evaluated. Focus was placed on publications supporting management of patients with CML in the chronic phase. Reports presenting clinical trial information of TKIs in development also were included. The discovery of targeted tyrosine kinase inhibition of BCR-ABL kinase dramatically changed the treatment of CML. Imatinib, the first TKI approved for treatment of patients with Philadelphia chromosome--positive CML, demonstrated significant superiority over the previous standard of care: interferon plus cytarabine. The newer, more potent TKIs, nilotinib and dasatinib, have demonstrated improved efficacy over imatinib as first-line therapy and provide an effective option for patients with resistance or intolerance to imatinib. To maximize efficacy of TKI therapy, close patient management, involving frequent monitoring of patient response, is essential. Given the importance of continuing TKI therapy, early recognition and management of adverse events are critical to optimizing outcomes in patients with CML. In addition to the safety profile and considerations of comorbidities, additional factors can affect therapeutic selection, including drug-drug and drug-food interactions. Research investigating new therapies, particularly for patients harboring the T315I mutation-which remains refractory to current TKIs-continues in the quest to improve outcomes in patients with CML.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
It was a comfortable sunny Sunday. I was going to meet an old university friend I hadn't seen for years, and was really excited to hear all his news. My train was running a little late, but that was no big problem - I could text him to say I would be delayed. He would understand. But... where was my mobile phone? I had that familiar sinking feeling. Yes, I'd forgotten it at home. No mobile phone. I'm sure I'm not alone in feeling anxious, _ and worried when I don't have my phone with me. In fact, I know I'm not alone: two-thirds of us experience 'nomophobia', the fear of being out of mobile phone contact. That's according to a study from 2012 which surveyed 1,000 people in the UK about their relationship with mobile phones. It says we check our mobile phones 34 times a day, that women are more 'nomophobic'than men, and that 18-24 year-olds are the most likely to suffer fear of being without their mobiles: 77% of them say they are unable to be apart from their phones for more than a few minutes. Do you have nomophobia ? * You never turn your phone off * You obsessively check for texts, missed calls and emails* You always take your phone to the bathroom with you* You never let the battery run out It's funny to think that around 20 years ago the only people with mobile phones would be businessperson carrying their large, plastic 'bricks'. Of course, these days, mobile phones are everywhere. A UN study from this year said mobile phone subscriptions would outnumber people across the world by the end of 2014. And when there are more phones than people in the world, maybe it's time to ask who really is in charge? Are you in control of your phone, or does your phone control you? So, what happened with my university friend? When I arrived a few minutes late he just laughed and said: "You haven't changed at all - still always late!" And we had a great afternoon catching up, full of jokes and stories, with no interruptions and no nagging desire to check my phone. Not having it with me felt strangely liberating. Maybe I'll leave it at home on purpose next time.
Output: Which word is used to describe old mobile phones according to the passage?
The Ca2+ overload by Ca2+ influx via Na+/Ca2+ exchanger (NCX) is a critical mechanism in myocardial ischemia/reperfusion injury. We investigated protective effects of a novel selective inhibitor of NCX, SEA0400, on cardiac function and energy metabolism during ischemia and reperfusion. Langendorff-perfused rat hearts were exposed to 35 minutes global ischemia and 40 minutes reperfusion. Using 31P nuclear magnetic resonance spectroscopy, cardiac phosphocreatine (PCr), ATP, and pHi were monitored. SEA0400 did not change the basic cardiac function, but improved the recovery of left ventricular developed pressure (LVDP) after reperfusion (27.6 +/- 4.9 mm Hg in control, 101.2 +/- 19.3 mm Hg in 0.1 microM, and 115.5 +/- 13.3 mm Hg in 1 microM SEA0400, means +/- SE, n = 6, P < 0.05). SEA0400 reduced left ventricular end-diastolic pressure and increased coronary flow after reperfusion. SEA0400 improved the recoveries of cardiac phosphocreatine and ATP after reperfusion, but did not affect pHi. There were significant linear correlations between left ventricular developed pressure and cardiac phosphocreatine (r = 0.79, P < 0.05), and left ventricular developed pressure and ATP (r = 0.80, P < 0.05). However, SEA0400 increased the incidence and duration of reperfusion ventricular arrhythmias. SEA0400 added only after reperfusion also improved both the contractile function and energy metabolism. It is concluded that the selective inhibition of NCX may be effective to preserve high-energy phosphates and to improve cardiac function after reperfusion, but may not be able to prevent fatal arrhythmias.
Output: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
The Neumark ( listen ), also known as the New March (Polish: Nowa Marchia) or as East Brandenburg (German: Ostbrandenburg ), comprised a region of the Prussian province of Brandenburg, Germany, located east of the Oder River in territory which became part of Poland in 1945.
Output: By which body of water is Neumark located?
Sharpe's Challenge is a British TV film from 2006, usually shown in two parts, which is part of an ITV series based on Bernard Cornwell's historical fiction novels about the English soldier Richard Sharpe during the Napoleonic Wars.
Output: Which is the basis of Sharpe's Challenge?
Autosomal-recessive hereditary spastic paraplegias (AR-HSP) consist of a genetically diverse group of neurodegenerative diseases characterised by pyramidal tracts dysfunction. The causative genes for many types of AR-HSP remain elusive. We tried to identify the gene mutation for AR-HSP with cerebellar ataxia and neuropathy. This study included two patients in a Japanese family with their parents who are first cousins. Neurological examination and gene analysis were conducted in the two patients and two normal family members. We undertook genome-wide linkage analysis employing single nucleotide polymorphism arrays using the two patients' DNAs and exome sequencing using one patient's sample. We detected a homozygous missense mutation (c.4189T>G, p.F1397V) in the lysosomal trafficking regulator (LYST) gene, which is described as the causative gene for Chediak-Higashi syndrome (CHS). CHS is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction. This mutation was co-segregated with the disease in the family and was located at well-conserved amino acid. This LYST mutation was not found in 200 Japanese control DNAs. Microscopic observation of peripheral blood in the two patients disclosed large peroxidase-positive granules in both patients' granulocytes, although they had no symptoms of immune deficiency or bleeding tendency. We diagnosed these patients as having adult CHS presenting spastic paraplegia with cerebellar ataxia and neuropathy. The clinical spectrum of CHS is broader than previously recognised. Adult CHS must be considered in the differential diagnosis of AR-HSP.
Output: Which mutated gene causes the Chédiak–Higashi Syndrome?
You're in your office when you learn there's someone with a gun wandering outside. You can hear gunshots and screams. What do you do? That's the challenge for users of a new virtual reality program called SurviVR, designed to train employees how to deal with an active shooter situation in the workplace. The program works with HTC Vive, the virtual reality headset released earlier this year. An active shooter situation is when an armed person or people actively shoot in a small, populated area with the intention to kill. There were 20 such situations in the United States last year and 20 the year before, according to FBI statistics, resulting in a total of 231 deaths. This year saw the deadliest active shooter situation in US history , with 49 people killed in a nightclub in Orlando. In the training situation, users have four choices. They can lock themselves in the office. They can hide, perhaps in the office closet. They can run for an exit. Or they can use something in the office--a computer or a cup a pair of scissors-as a weapon to fight the shooter. This is an improvement on standard active shooter training. Gallo says, which typically teachers people to lock themselves in place and hide. The "lock down" method is often ineffective, he says, and has resulted in many deaths in recent years. In the training's basic level, no one gets killed. But as the trainings become more advanced, players who make a wrong choice be shot. There's no blood; the screen simply turns black slowly. If this sounds terrifying, that's the point, says Gallo. There are plenty of training programs to teach employees how to deal with workplace violence, sometimes involving role play with toy guns. But these trainings are basically games. Gallo says, with employees relaxed and even enjoying themselves. To teach people what they really need to know for an active shooter situation, they need to be scared. "SurviVR will take the fear and turn it into confidence." Gallo says.
Output: What does Gallo think of the training programs involving role play with toy guns?
The Jets' seventh game was an interconference duel with the Packers. Punter Steve Weatherford made the game's most controversial decision in the first quarter, opting to attempt a fake punt and run for the first down on 4th and 18. Weatherford was stopped a yard short of the first down, giving the Packers ideal field position which eventually led to an early 3-0 Packers lead. "He does it on his own," Ryan said. "(The Packers) were caving that side down. This was something Steve did on his own. I don't think he realized we'd just been sacked. We told him before that it needed to be a manageable situation, not fourth-and-20 or whatever it was.". In a game where defense ruled, the Packers lead 3-0 at halftime. The Jets challenged a Brad Smith fumble, and lost due to his knee not being down before losing the ball. However, the Jets second challenge went to a jump ball, called an interception after Packers cornerback Tramon Williams ripped the ball out of Jerricho Cotchery's hands while they were both on the ground. The play was controversially upheld, despite the fact that the receiver appeared to be down by contact. With no challenges left, Mark Sanchez threw a ball to Dustin Keller that was ripped out of his hands and ruled an interception in the 4th quarter. The replay showed that Keller made the catch and was also down before losing possession, but with no challenges left the Jets were left with nothing. Green Bay took a 6-0 lead after the turnover. The Jets had two more chances to take the lead but had drives halted on 4th and longs. The Packers added on another field goal late to finalize a 9-0 win in the New Meadowlands Stadium. This marked the first time since 2006 the Jets were shut out.
Output: Which team scored the least points?
Small supernumerary marker chromosomes (sSMC) can be present in numerically abnormal karyotypes like in a 'Turner-syndrome karyotype' mos 45,X/46,X,+mar. Here we report the first case of an sSMC found in Turner syndrome karyotypes (sSMCT) derived from chromosome 14 in a Turner syndrome patient. According to cytogenetic and molecular cytogenetic characterization the karyotype was 46,X,+del(14)(q11.1). The present case is the third Turner syndrome case with an sSMCT not derived from the X- or the Y-chromosome. More comprehensive characterization of such sSMCT might identify them to be more frequent than only ~0.6% in Turner syndrome cases according to available data.
Output: What chromosome is affected in Turner's syndrome?
To investigate the clinicopathologic features of focal cortical dysplasia (FCD) in patients with refractory epilepsy. The clinical, radiologic and pathologic features of 38 cases of FCD receiving surgical treatment in 2005 were reviewed retrospectively. The mean age of disease onset was 9.2 years. The disease lasted for 11.9 years on average and often presented as complex partial seizure. Radiologic examination revealed hippocampal sclerosis, or abnormal signals in the grey matter in 21 cases. According to Palmini's classification system, the following pathologic subgroups were identified: FCD type IA (3/38), FCD type IB (20/38), FCD type IIA (5/38) and FCD type IIB (5/38). The remaining 5 cases were classified as mild cortical dysplasia. Topographically, FCD type II was often seen in the extratemporal region (8/10), predominantly in the frontal lobe (5/8). Dual pathology was identified only in cases with FCD type IB. Immunohistochemical study showed that the giant neurons, immature neurons and dysmorphic neurons were strongly positive for NeuN. A small number of balloon cells expressed nestin. FCD is a common cause of refractory epilepsy. FCD type IB is the predominant pathologic subtype. Associated hippocampal sclerosis is sometimes seen. Clinicopathologic differences between FCD type I and FCD type II are observed.
Output: Which disorder is rated by Palmini classification?
A Youth with a Jug is an oil painting currently in a private collection.
Output: What is the name of the place where A Youth with a Jug can be found?
Metalloids are the smallest class of elements. (The other two classes of elements are metals and nonmetals). There are just six metalloids. In addition to silicon, they include boron, germanium, arsenic, antimony, and tellurium. Metalloids fall between metals and nonmetals in the periodic table. They also fall between metals and nonmetals in terms of their properties. Q: How does the position of an element in the periodic table influence its properties? A: Elements are arranged in the periodic table by their atomic number, which is the number of protons in their atoms. Atoms are neutral in electric charge, so they always have the same number of electrons as protons. It is the number of electrons in the outer energy level of atoms that determines most of the properties of elements. How metalloids behave in chemical interactions with other elements depends mainly on the number of electrons in the outer energy level of their atoms. Metalloids have from three to six electrons in their outer energy level. Boron, pictured in the Figure 1.1, is the only metalloid with just three electrons in its outer energy level. It tends to act like metals by giving up its electrons in chemical reactions. Metalloids with more than four electrons in their outer energy level (arsenic, antimony, and tellurium) tend to act like nonmetals by gaining electrons in chemical reactions. Those with exactly four electrons in their outer energy level (silicon and germanium) may act like either metals or nonmetals, depending on the other elements in the reaction. Most metalloids have some physical properties of metals and some physical properties of nonmetals. For example, metals are good conductors of both heat and electricity, whereas nonmetals generally cannot conduct heat or electricity. And metalloids? They fall between metals and nonmetals in their ability to conduct heat, and if they can conduct electricity, they usually can do so only at higher temperatures. Metalloids that can conduct electricity at higher temperatures are called semiconductors. Silicon is an example of a semiconductor. It is used to make the tiny electric circuits in computer chips. You can see a sample of silicon and a silicon chip in the Figure 1.2. Metalloids tend to be shiny like metals but brittle like nonmetals. Because they are brittle, they may chip like glass or crumble to a powder if struck. Other physical properties of metalloids are more variable, including their boiling and melting points, although all metalloids exist as solids at room temperature. Click image to the left or use the URL below. URL:
Output: metalloids are generally
LYST is a large cytosolic protein that influences the biogenesis of lysosome-related organelles, and mutation of the encoding gene, LYST, can cause Chediak-Higashi syndrome. Recently, Lyst-mutant mice were recognized to also exhibit an iris disease resembling exfoliation syndrome, a common cause of glaucoma in humans. Here, Lyst-mutant iris phenotypes were used in a search for genes that influence Lyst pathways. In a candidate gene-driven approach, albino Lyst-mutant mice homozygous for a mutation in Tyr, whose product is key to melanin synthesis within melanosomes, exhibited complete rescue of Lyst-mutant iris phenotypes. In a genetic background-driven approach using a DBA/2J strain of congenic mice, an interval containing Tyrp1 enhanced Lyst-dependent iris phenotypes. Thus, both experimental approaches implicated the melanosome, an organelle that is a potential source of oxidative stress, as contributing to the disease phenotype. Confirming an association with oxidative damage, Lyst mutation resulted in genetic context-sensitive changes in iris lipid hydroperoxide levels, being lowest in albino and highest in DBA/2J mice. Surprisingly, the DBA/2J genetic background also exposed a late-onset neurodegenerative phenotype involving cerebellar Purkinje-cell degeneration. These results identify an association between oxidative damage to lipid membranes and the severity of Lyst-mutant phenotypes, revealing a new mechanism that contributes to pathophysiology involving LYST.
Output: Which syndrome is associated with mutations in the LYST gene?
Brigadier Sir Iltyd Nicholl Clayton CBE (1886 -- 30 June 1955) was a British Army officer notable for his attachment to the Middle East Office in Cairo during and after World War II and his involvement in the formation of Arab League and formulation of post-war British policy in the Middle East.
Output: Who did Iltyd Nicholl Clayton serve for?
PunBB (PunBulletinBoard) is a lightweight PHP-based internet discussion board system.
Output: What programming language was used to write PunBB?
Remo Giazotto (September 4, 1910, Rome -- August 26, 1998, Pisa) was an Italian musicologist, music critic, and composer, mostly known through his systematic catalogue of the works of Tomaso Albinoni.
Output: The nationality of Remo Giazotto is what?
A family with the Romano-Ward syndrome is presented. This family showed typical features of this syndrome with QT prolongation, torsades de pointes ventricular tachycardia, sudden death and an autosomal dominant inheritance pattern. The index case presented with an exacerbation of torsades de pointes ventricular tachycardia from diuretic induced hypokalaemia, and responded to diuretic withdrawal and beta blocker therapy.
Output: What is the mode of inheritance of Romano Ward long QT syndrome?
Elite Lessons Experienced music performer is offering one-on-one drum lesson. As the winner of the Drummer Contest, the largest drummer contest in Canada, I can teach you secret techniques that only an elite group knows, but the group doesn't share them with the public. The result is instant improvement in your speed and ability to play the drum. Lessons are taught in French or English, $25 an hour. Call at 514-585-5054 if you want to know more information. Private Tutoring Professional French tutor is offering French tutoring, $15 an hour. I possess a BA in translation from Concordia University and have over 5 years' teaching experience. The course consists of conversational French, grammar, reading comprehension ,etc. Courses are given in the downtown area. For more information please call at 514-835-1834. Customized Tutoring Hello, my name is Christopher Marion. I am a graduate students at Concordia University, 21 years of age. I was born and lived in France for 17 years. I will be happy to provide customized help in French writing or speaking. The lesson's style can be whatever suits your needs. I am charging $19 an hour. I live in downtown Montreal. Feel free to contact me at 514-785-5654. Basic Lessons for Beginners Always wanted to learn the guitar? This is your chance and it only costs $14 an hour. I can teach you to play any style of music you like in a fun and relaxed way. I start from the basics, showing you how to play the songs you love, and improving your technique as we go along. If you don't already have a guitar, that's not a problem. Please call at 514-880-8872 or email totarungeo@gmail.comif interested. Thanks!.
Output: How much shall you pay for a basic guitar lesson?