niryuu/sni-each-converted huggingface dataset:
Fostamatinib (R788) is a prodrug rapidly converted to its active metabolite on oral administration. This (known as R406) is a potent inhibitor of spleen tyrosine kinase, required for the expression of a number of proinflammatory cytokines. Fostamatinib has shown significantly superior efficacy (when compared with placebo) in the control of patients with rheumatoid arthritis not responding to methotrexate in Phase II clinical trials. Treatment emergent adverse events with a higher frequency than in those on placebo included diarrhea, hypertension, urinary tract infections, neutropenia and elevated transaminases. The studied doses have shown a linear pharmacokinetic pattern and the administration of methotrexate does not affect it. Fostamatinib may have a role in the therapy of patients with rheumatoid arthritis with poor response to conventional therapy. If these results are confirmed once Phase III studies are completed, it may find a place in the evolving treatment algorithm for rheumatoid arthritis.
Output: Which enzyme is inhibited by a drug fostamatinib?
Mira Bjedov, married Nikolic, (born 7 September 1955 in Mokro Polje) is a former basketball player who competed for Yugoslavia in the 1980 Summer Olympics.
Output: What is Mira Bjedov's birthplace?
Claire Ridgway (born 1971) is a British writer of history books about the Tudor dynasty, with a particular focus on the life of the Boleyn family.
Output: When was the birth of Claire Ridgway?
In a time when a dangerous number of people are overweight, many people seem to have forgotten the most important way to keep healthy and slim---exercise. And as a new study carried out on mice in the lab has shown, exercise done early in life can reward you in your adult years. A team of researchers at the University of California studied the effects of early exercise on adult physical activity, body mass and eating. They found that early-age exercise in mice has positive effects on adult levels of voluntary exercise in addition to reducing body mass. "These results may have an effect on the importance of regular physical education in elementary and middle schools," said Theodore Garland, a professor of biology, who led the research project. "If kids exercise regularly through their school years, then they may be more likely to exercise as adults, which could have far-reaching positive effects on human health and well-being." Although the positive effects of early-life exercise lasted for only one week, it is important to note that one week in the life of a mouse is the same as about nine months for humans. "Our results suggest that any positive effects of early-life exercise on adult exercise will need to be kept up if they are to be long-lasting." His team of researchers found, too, that all mice that had access to early exercise were lighter in weight than non-exercised mice. Garland explained that, in general, exercise will stimulate appetite sooner or later. However, it is possible that certain types of exercise, done for certain periods of time or at certain light levels, might not _ appetite much, if at all, at least in some individuals. "If we could understand what sorts of exercise these might be, then we might be able to tailor exercise recommendations in a way that would bring the benefits of exercise without increase in appetite, leading to a better chance of weight loss," he said.
Output: What is the article mainly about?
Coming off their home win over the Rams, the Bengals flew to Bill Walsh Field at Monster Park for a Saturday night interconference duel with the San Francisco 49ers. After a scoreless first quarter, Cincinnati trailed early in the second quarter as 49ers QB Shaun Hill got a 3-yard TD run. Afterwards, the Bengals would take the lead as kicker Shayne Graham managed to get a 24-yard field goal, while QB Carson Palmer completed a 52-yard TD pass to WR Chris Henry. San Francisco would end the half with Hill completing a 17-yard TD pass to TE Vernon Davis. In the third quarter, the 49ers increased their lead with kicker Joe Nedney getting a 29-yard and a 38-yard field goal. In the fourth quarter, Cincinnati tried to respond as Graham kicked a 35-yard field goal. However, the 49ers' defense held on for the win. With the loss, the Bengals fell to 5-9, securing Head Coach Marvin Lewis' first losing season with Cincinnati.
Output: Which quarterback rushed for a touchdown?
On 30 March 1922, a part of the territory of Montigny-les-Cormeilles was detached and merged with a part of the territory of Taverny and a part of the territory of Pierrelaye to create the commune of Beauchamp.
Output: What was replaced Montigny-lès-Cormeilles?
Borders Group, Inc. (former NYSE ticker symbol BGP) was an international book and music retailer based in Ann Arbor, Michigan.
Output: What city is the headquarters of Borders Group?
After periods with Shamrock Rovers, Shelbourne and University College Dublin A.F.C., O Snodaigh was a squad member of the successful Bray Wanderers side that won the 1989-90 FAI Cup in at Lansdowne Road with a 3-0 victory against St Francis, lost in the European Cup Winners Cup tie against Trabzonspor, and finished runners-up in the 1990-91 League of Ireland First Division. That same year he was a central member of Wanderers reserve side that finished runners-up in the League of Ireland B Division. He won the B team player of the year award in 1990 and was a member of the first team that lost the LFA President's Cup final 3-1 against Dundalk. In time he left Bray and became a member of Leinster Senior League side Pegasus where, over a seven-year period, he was a member of their FAI Intermediate Cup winning team in 1992 against Bluebell United, top scorer in 1996/7, selected for the Leinster Senior League selection team in 1992, was captain of the side that got relegated from the senior division in 1997 following a defeat away to Bluebell and played in every position for the side except goalkeeper.
Output: Who won an award
''Down on Love'' was the fifth and final single taken from the album Agent Provocateur by the band Foreigner, and primarily released only in the U.S. in September 1985.
Output: The song or album Down on Love came from which artiste?
Christopher George died of a sudden heart attack on the late evening of November 28, 1983 in a Westside Hospital in Los Angeles, California at the age of 52.
Output: Which is the cause of death of Christopher George?
The Turin King List, also known as the Turin Royal Canon, is an Egyptian hieratic papyrus thought to date from the reign of Pharaoh Ramesses II, now in the Museo Egizio (Egyptian Museum) in Turin.
Output: What material was used for Turin King List?
There is always a man who stands on different comers of the street in our city, holding a sign that reads "Will work for food for my family". Normally I don't have much money to help him. When my mother is with me and she sometimes makes me pull over and then she will hand him some money. Tonight, I was on my way to the store to get some milk when I saw the man. My daughter and her friend were in the car. We all felt awful that this man was standing out in the cold, wet weather. Many people had made comments that he should be able to work. I often wondered why he would stand out there rather than be in the warmth of a building, working. Well, he might not have an address, and he may need an address in order to apply for a job. Either way, I don't feel it is _ to judge. As I was sharing that feeling with my daughter and her friend, I decided that I needed to help this man. I wanted to show the girls the importance of helping others, not about worrying whether he was legitimately struggling or not. So, when we pulled over to give him some money, I said, "God bless you," and he said it back to us. But the girls and I were still concerned that he would be cold, standing out in the bad weather. So we got him a hot chocolate and a hamburger. My daughter handed them to him and l told the man that the girl wanted to help him because she was worried about him being cold. He was very sweet and appreciative. We all left with smiles, especially me, because, as we were pulling away, the girls were talking about ways they could raise money to help the man and others like him. It was the best trip I have ever made to get milk!!!
Output: Why did the author decide to help the man?
Singles' Day, also called Double Eleven, began as a day for unmarried or uncoupled people to celebrate their lives on November 11, 1993. In China, however, Singles' Day has become the biggest online shopping day in the world, which was created in 2009 by Alibaba's CEO Daniel Zhang to increase online sales. Since then, it has grown into a cultural phenomenon. China Singles' Day, as a shopping day, takes place on November 11 each year. There are sharp _ and other promotions designed by Alibaba to attract online customers. In 2015, E-commerce giant Alibaba broke records with sales of $14.3 billion on China Singles' Day, with online sales increasing 60 percent from last year, according to Alibaba. "Most people shop on mobile phones or ipads and online shopping has become a comfortable channel for most consumers", said Kitty Fok, China manager for market research. "China is a big market with close to one billion smart, connected device users. It is good news for both Alibaba and their competitors," she said. The company is focusing on international e-commerce for future Singles' Days, reported Reuters. "Within the next five years, we expect China will become the world's largest e-commerce market for imported products," President Michael Evans told reporters on Wednesday. Alibaba Chief Executive Daniel Zhang said in a statement that Singles' Day would mean that "the whole world will see the power of Chinese consumption." Over 130 million users visited Alibaba's marketplace app, Taobao, reported the BBC.
Output: What does Alibaba expect to do on Singles' Day?
The revolt of the pitauds was a French peasants' revolt in the mid-16th century. The revolt was sparked by the 1541 decree of Chatellerault, which extended a salt tax to Angoumois and Saintonge . It was made compulsory to purchase salt from the salt loft . "Gabelle" officers took charge of punishing the unlawful trading of salt. But these were salt pan areas where the salt was freely traded. Salt smuggling spread rapidly, especially after the Marennes and La Rochelle revolts in 1542, and the repression by the salt riders is out of the population acceptance. In 1548, riots break out in Angoumois and Saintonge demanding the release of the smugglers . The de Pitauds revolt grew to 20,000 members, led by a lord and joined by priests. Castles were plundered and salt-tax collectors killed. The revolt spread to Bordeaux where 20 salt tax collectors were killed, including the lieutenant governor, on August 21, 1548. King Henry II blockaded Bordeaux and launched his repression. Bordeaux lost its privileges. It was disarmed, paid a fine, saw its parliament suspended, and 1,401 people were sentenced to death. The repression spread to the countryside where the leaders were hanged: neither priests nor gentlemen were spared. The salt-tax was finally abolished in these provinces in June 1549, the provinces became redeemed countries, and the King issued a general amnesty.
Output: Which occurred first, the decree of Châtellerault or Marennes and La Rochelle revolts?
Pittosporum viridulatum is a critically endangered species of plant in the Pittosporaceae family.
Output: What is the conservation status of Pittosporum viridulatum?
Neuroacanthocytosis syndromes are mainly comprised of two diseases: chorea-acanthocytosis (ChAc) and McLeod syndrome (MLS). There is a high incidence of psychiatric disorders such as mood disorder and schizophrenia among neuroacanthocytosis patients. We hypothesized that neuroacanthocytosis-related-genes might be associated with susceptibility to these psychiatric disorders. We performed a comprehensive mutation screen of VPS13A and XK, the gene responsible for ChAc and MLS, respectively, in 85 mood disorder subjects and XK in 86 schizophrenia subjects and compared the variants to 100 or more control alleles. We also performed copy number variation (CNV) analysis in 72 mood disorder subjects and 86 schizophrenia subjects. We identified three non-synonymous, two synonymous and six intron variants in mood disorder subjects and a novel GAT triplet repeat polymorphism in VPS13A. By CNV analysis, we identified a heterozygous exon 60-61 deletion in VPS13A in one mood disorder subject. We identified one non-synonymous and one intron variant in mood disorder and schizophrenia subjects, respectively, in XK. The presence of a pathogenic mutation or a potentially functional variant in mood disorder or schizophrenia subjects suggests that neuroacanthocytosis-related-genes might be involved in the pathogenesis of these psychiatric disorders.
Output: Mutation of which gene is associated with McLeod syndrome?
The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its function is crucial to cellular homeostasis. First synthesized as probes of proteolytic processes, proteasome inhibitors began to be thought of as potential drug candidates when they were found to induce programmed cell death preferentially in transformed cells. They made their first leap into the clinic to be tested as therapeutic agents 10 years ago, and since then, great strides have been made in defining their mechanisms of action, their clinical efficacy and toxicity, and some of their limitations in the form of resistance pathways. Validation of the ubiquitin-proteasome pathway as a target for cancer therapy has come in the form of approvals of the first such inhibitor, bortezomib, for relapsed/refractory multiple myeloma and mantle cell lymphoma, for which this agent has become a standard of care. Lessons learned from this first-in-class agent are now being applied to the development of a new generation of proteasome inhibitors that hold the promise of efficacy in bortezomib-resistant disease and possibly in a broader spectrum of diseases. This saga provides a salient example of the promise of translational medicine and a paradigm by which other agents may be successfully brought from the bench to the bedside.
Output: Which is the target of bortezomib used in cancer therapy?
Andrew Gay (born 5 October 1989 in Central Coast, New South Wales, Australia) is a rugby league player for Wales and for the South Wales Scorpions in the Championship One.
Output: What is Andrew Gay's country of original?
Do's and Don'ts in Whale Watching The Department of Fisheries and Oceans has developed guidelines for whale watching in Johnstone Strait,where killer whales are found on a daily basis each summer. It is strongly recommended that vessel operators follow these guidelines for all kinds of whales. * Approach whales from the side, not from the front or the back. * Approach no closer than 100 metres, then stop the boat but keep the engine on. * Keep noise levels down-no horns, whistles or racing of engines. * Start your boat only after the whales are more than 100 metres from your vessel. * Leave the area slowly, gradually moving faster when you are more than 300 metres from the whales. * Approach and leave slowly, avoiding sudden changes in speed or direction. * Avoid disturbing groups of resting whales. * Keep at low speeds and remain in the same direction if travelling side by side with whales. * When whales are travelling close to shore, avoid crowding them near the shore or coming between the whales and the shore. * Limit the time spent with any group of whales to less than 30 minutes at a time when within 100 to 200 metres of whales. * If there is more than one vessel at the same observation spot, be sure to avoid any boat position that would result in surrounding the whales. * Work together by communicating with other vessels, and make sure that all operators are aware of the whale watching guidelines.
Output: For whom is this text written?
Rachel (Andrea Bowen), a high school girl, seems to have the life that most people envy: she has a steady boyfriend, some great friends, and a place on the school's soccer team. Preparing for college and separating from her boyfriend are the main worries of this teen, as she lives a carefree life like most girls her age. However, Rachel's world falls apart the day she discovers that Jason (Eric von Detton), a former sexual partner of hers that died an untimely death, was in fact HIV positive and an IV drug user. She immediately goes to an AIDS clinic to get a rapid test, which unfortunately comes back positive. Devastated by the fact that she may actually be infected with the virus, Rachel then confides in her substitute teacher, Sarah (Jennie Garth), who has secretly been living with the disease for years. But both young women are about to find out their secrets will not be kept secret for very long, as word begins to spread throughout their high school and rumors fly, making some of these students realize that they may not be as "clean" as they think they are.
Output: What was Rachel's rapid test result at the HIV clinic?
Modeled after US hot website.com, group buying websites are now popular in China. These websites use the power of group buying to get competitive discounts for a daily deal on some best stuff to do, see, eat and buy in the cities across China. Discounts are available within just one click. Zhao lei, a software engineer in Beijing, loves the one-hour lunch break at noon,as it is the best time for him to check "today's special" at his favorite group buying websites . Sometimes he searches for great deals at directory sites devoted to the new shopping space. Zhao spends around 800 yuan($117.65) on group buying every month, mostly to buy food coupons for eating at some nice restaurants and occasionally to find something fun to do. " I love group buying. In addition to the competitive discounts it offers, it helps me get something fun, exciting and new, and such surprises give me a reason to try something new," he said. When he finds a really good bargain, he will send the link to friends or colleagues through MSN,QQ, or e-mail, or share the information at some social networking websites. In doing so, he often gets a certain cut off the price. At some sites, buyers are invited to leave notes about what they want to buy and the website will consider it if similar applications reach a certain number. That is how Zuo got her digital camera after waiting for two months. "It is cool. I want to buy a new digitgal camera for my trip to Switzerland this winter, but I never expected such cheap prices!" Zuo said.
Output: What is the passage mainly about?
Chronic myeloid leukemia (CML) is the first human malignancy for which the promise of targeted therapy has come true. CML is invariably associated with a specific genetic lesion--the t(9;22) chromosomal translocation. As a consequence of this translocation, a BCR-ABL fusion gene is formed on the 22q- derivative (traditionally known as the Philadelphia chromosome) and the deregulated tyrosine kinase activity of the protein encoded by this gene has been shown to be both necessary and sufficient for initiation and maintenance of the disease. Imatinib mesylate, an orally available tyrosine kinase inhibitor that targets Bcr-Abl, entered clinical evaluation in 1998. Its efficacy surpassed almost everyone's predictions, and the observation of high response rates and favorable toxicity profile associated with imatinib therapy led to its approval as first-line treatment for all newly diagnosed CML patients over an exceptionally short period of time. The 6-year results of the Phase III trial have recently been reported and confirm durability of responses and declining incidence of adverse events over time, although, at present, occurrence of unexpected side effects in the long term cannot be excluded. Although imatinib does not 'cure' CML and has to be administered chronically to patients, it has revolutionized both outcome and quality of life of CML patients.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Remember that H2 O is a polar molecule, so it can dissolve many substances (Figure 1.1). Salts, sugars, acids, bases, and organic molecules can all dissolve in water. Where does the salt in seawater come from? As water moves through rock and soil on land it picks up ions. This is the flip side of weathering. Salts comprise about 3.5% of the mass of ocean water, but the salt content, or salinity, is different in different locations. What would the salinity be like in an estuary? Where seawater mixes with fresh water, salinity is lower than average. What would the salinity be like where there is lots of evaporation? Where there is lots of evaporation but little circulation of water, salinity can be much higher. The Dead Sea has 30% salinity nearly nine times the average salinity of ocean water (Figure 1.2). Why do you think this water body is called the Dead Sea? In some areas, dense saltwater and less dense freshwater mix, and they form an immiscible layer, just like oil and water. One such place is a "cenote", or underground cave, very common in certain parts of Central America. Ocean water is composed of many sub- stances, many of them salts such as sodium, magnesium, and calcium chlo- ride. Because of the increased salinity, the wa- ter in the Dead Sea is very dense, it has such high salinity that people can easily float in it! With so many dissolved substances mixed in seawater, what is the density (mass per volume) of seawater relative to fresh water? Water density increases as: salinity increases temperature decreases pressure increases Differences in water density are responsible for deep ocean currents, as will be discussed in the "Deep Ocean Currents" concept. Click image to the left or use the URL below. URL:
Output: water density increases when
The Ghost Dance War was an armed conflict in the United States between the Lakota Sioux and the United States government from 1890 until 1891.
Output: What year did Ghost Dance War start?
Selenium, an essential trace element, is incorporated into selenoproteins as selenocysteine (Sec), the 21st amino acid. In order to synthesize selenoproteins, a translational reprogramming event must occur since Sec is encoded by the UGA stop codon. In mammals, the recoding of UGA as Sec depends on the selenocysteine insertion sequence (SECIS) element, a stem-loop structure in the 3' untranslated region of the transcript. The SECIS acts as a platform for RNA-binding proteins, which mediate or regulate the recoding mechanism. Using UV crosslinking, we identified a 110 kDa protein, which binds with high affinity to SECIS elements from a subset of selenoprotein mRNAs. The crosslinking activity was purified by RNA affinity chromatography and identified as nucleolin by mass spectrometry analysis. In vitro binding assays showed that purified nucleolin discriminates among SECIS elements in the absence of other factors. Based on siRNA experiments, nucleolin is required for the optimal expression of certain selenoproteins. There was a good correlation between the affinity of nucleolin for a SECIS and its effect on selenoprotein expression. As selenoprotein transcript levels and localization did not change in siRNA-treated cells, our results suggest that nucleolin selectively enhances the expression of a subset of selenoproteins at the translational level.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
In physics, resistance is opposition to the flow of electric charges in an electric current as it travels through matter. The SI unit for resistance is the ohm. Resistance occurs because moving electrons in current bump into atoms of matter. Resistance reduces the amount of electrical energy that is transferred through matter. Thats because some of the electrical energy is absorbed by the atoms and changed to other forms of energy, such as heat. Q: In the rugby analogy to resistance in physics, what do the players on each team represent? A: The player on the blue and black team represents a moving electron in an electric current. The players on the red and blue team represent particles of matter through which the current is flowing. How much resistance a material has depends on several factors: the type of material, its width, its length, and its temperature. All materials have some resistance, but certain materials resist the flow of electric current more or less than other materials do. Materials such as plastics have high resistance to electric current. They are called electric insulators. Materials such as metals have low resistance to electric current. They are called electric conductors. A wide wire has less resistance than a narrow wire of the same material. Electricity flowing through a wire is like water flowing through a hose. More water can flow through a wide hose than a narrow hose. In a similar way, more current can flow through a wide wire than a narrow wire. A longer wire has more resistance than a shorter wire. Current must travel farther through a longer wire, so there are more chances for it to collide with particles of matter. A cooler wire has less resistance than a warmer wire. Cooler particles have less kinetic energy, so they move more slowly. Therefore, they are less likely to collide with moving electrons in current. Materials called superconductors have virtually no resistance when they are cooled to extremely low temperatures. Resistance can be helpful or just a drain on electrical energy. If the aim is to transmit electric current through a wire from one place to another, then resistance is a drawback. It reduces the amount of electrical energy that is transmitted because some of the current is absorbed by particles of matter. On the other hand, if the aim is to use electricity to produce heat or light, then resistance is useful. When particles of matter absorb electrical energy, they change it to heat or light. For example, when electric current flows through the tungsten wire inside an incandescent light bulb like the one in the Figure 1.1, the tungsten resists the flow of electric charge. It absorbs electrical energy and converts some of it to light and heat. Q: The tungsten wire inside a light bulb is extremely thin. How does this help it do its job? A: The extremely thin wire has more resistance than a wider wire would. This helps the wire resist electric current and change it to light.
Output: the si unit for electric resistance is the
Esra Erol (6 November 1985) is a Turkish female footballer currently playing in the Turkish First League in defender position for Kirecburnu Spor in Istanbul.
Output: Player Esra Erol plays for what team?
Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the overproduction of granulocytes, which leads to high white blood cell counts and splenomegaly in patients. Based on clinical symptoms and laboratory findings, CML is classified into three clinical phases, often starting with a chronic phase, progressing to an accelerated phase and ultimately ending in a terminal phase called blast crisis. Blast crisis phase of CML is clinically similar to an acute leukemia; in particular, B-cell acute lymphoblastic leukemia (B-ALL) is a severe form of acute leukemia in blast crisis, and there is no effective therapy for it yet. CML is induced by the BCR-ABL oncogene, whose gene product is a BCR-ABL tyrosine kinase. Currently, inhibition of BCR-ABL kinase activity by its kinase inhibitor such as imatinib mesylate (Gleevec) is a major therapeutic strategy for CML. However, the inability of BCR-ABL kinase inhibitors to completely kill leukemia stem cells (LSCs) indicates that these kinase inhibitors are unlikely to cure CML. In addition, drug resistance due to the development of BCRABL mutations occurs before and during treatment of CML with kinase inhibitors. A critical issue to resolve this problem is to fully understand the biology of LSCs, and to identify key genes that play significant roles in survival and self-renewal of LSCs. In this review, we will focus on LSCs in CML by summarizing and discussing available experimental results, including the original studies from our own laboratory.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
A mutation in the ubiquilin 2 gene (UBQLN2) was recently identified as a cause of X-linked amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and a major component of the inclusion bodies commonly found with a wide variety of ALS. ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system. However, the molecular properties of mutant UBQLN2 remain unclear. To gain insight into the pathogenesis of UBQLN2-linked ALS/FTD, we examined the biochemical and cellular characteristics of mutant UBQLN2 in vitro. UBQLN2 localized in Rab11-positive endosomal vesicles formed by the ALS-linked molecule optineurin (OPTN). These vesicles were ubiquitin- and p62-immunopositive and also co-localized with an initiator of the autophagic process, ULK1, after amino acid starvation. An ALS-linked mutation (E478G) in OPTN abolished vesicle formation. ALS-linked mutations in UBQLN2 additively enhanced UBQLN2 aggregation and formation of inclusion bodies, resulting in mislocation from OPTN vesicles. UBQLN2 was found to be a potent regulator of the levels of the FTD-linked secretory factor progranulin, possibly via the endosomal system, and ALS-linked mutations disturbed these functional consequences. This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. These data suggest a novel disease spectrum and provide new pathological insights into OPTN and UBQLN2, enhancing our understanding of the molecular basis of ALS/FTD.
Output: Which human disease is associated with mutated UBQLN2
Born to Maharaja Sawai Man Singh II and his first wife, Marudhar Kanwar of Jodhpur, Bhawani Singh was educated at Sheshbagh School, Srinagar, The Doon School, Dehradun, and later Harrow School in the United Kingdom.
Output: Who was Bhawani Singh's father?
The Three Little Wolves and the Big Bad Pig is a children's picture book written by Eugene Trivizas (Evgenios Trivizas), illustrated by Helen Oxenbury, and first published by Heinemann in 1993.
Output: Who was The Three Little Wolves and the Big Bad Pig illustrated by?
Shaka Sankofa (born Gary Lee Graham) (September 5, 1963 -- June 22, 2000) was a Texas death-row inmate who was sentenced to death at the age of 18 for the murder of fifty-three-year-old Bobby Grant Lambert in Houston, Texas on May 13, 1981.
Output: For what crime was Shaka Sankofa prosecuted?
Alexander Bertschler (born 11 July 1994) is a male recurve archer from Austria.
Output: What was Alexander Bertschler's gender?
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterised by joint hypermobility, involvement of skin and tissue fragility. The Villefranche criteria have simplified its diagnosis, which, however, remains difficult in children and young adults with vascular and hypermobile EDS as well as in patients without a positive family history. Diagnosis of vascular EDS is important for clinical follow-up, genetic counseling and prenatal diagnosis. We describe the biochemical and molecular-genetic diagnosis of vascular EDS. We describe five families with vascular EDS. Analysis of (pro)collagens obtained from cultured fibroblasts was done using SDS-PAGE. The structure and amounts of (pro)collagen I, III and V were determined by autoradioflourography. This was also done in 362 controls or patients without a diagnosis of vascular EDS. Molecular testing was done in Professor Anne de Paepe's laboratory in Belgium by sequencing of COL3A1. (Pro)collagen from all five patients with vascular EDS was abnormal by SDS-PAGE: intracellular retention, reduced secretion and overmodification of the a1 chains of (pro)collagen III. Molecular analysis revealed an abnormality of COL3A1 in all patients. Abnormalities of (pro)collagen III were not observed in patients without a diagnosis of vascular EDS. Among 90 patients with non-vascular EDS, one patient had an abnormality of collagen I. Biochemical analysis of (pro)collagen obtained from cultured fibroblasts is a good screening procedure for vascular EDS, but it is of limited value in non-vascular EDS. Molecular testing will disclose an abnormality of COL3A1 in many patients with abnormal (pro)collagen III on SDS-PAGE. The findings make precise genetic counselling and prenatal diagnosis possible in families with vascular EDS.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
Welcome to Adventureland! Everyone loves Adventureland !The Parks and Exhibitions were built for you to explore ,enjoy,and admire their wonders.Every visit will be an unforgettable experience.You will go away enriched,longing to come back.What are you going to do this time? The Travel Pavilion Explore places you have never been to before,and experience different ways of life.Visit the Amazon jungle village,the Turkish market,the Tai floating market,the Berber mountain house and others.Talk to the people there who will tell you about their lives,and things they make.You can try making a carpet,making nets,fishing... The Future Tower This exhibition shows how progress will touch our lives.It allows us to look into the future and explore the cities of the next century and the way we'll be living then.Spend some time in our space station and climb into our simulator for the Journey to Mars! The Nature Park This is not really one park but several.In the Safari Park you can drive among African animals in one of our Range Cruisers:see lions,giraffes,elephants in the wild.Move on to the Ocean Park to watch the dolphins and whales.And then there is still the Aviary to see... The Pyramid This is the center of Adventureland.Run out of film,need some postcards and stamps?For all these things and many more,visit our underground shopping center.Come here for information and ideas too.
Output: If you want to get a toy lion to take home,where will you most likely go?
The Gora Rudnaya mine is one of the largest gold mines in Russia and in the world.
Output: What product does Gora Rudnaya mine make?
Our objective was to evaluate the efficacy of influenza and meningococcal vaccinations in healthy subjects exposed to the anti-interleukin-17A (IL-17A) monoclonal antibody (MAb) secukinumab. We used an open-label, parallel-group, randomized single-center study of 50 healthy subjects. Subjects received a single 150-mg dose of secukinumab or no treatment, followed by vaccination with inactivated trivalent subunit influenza virus and conjugate group C meningococcal vaccine (Agrippal and Menjugate, respectively) 2 weeks later. Primary efficacy variables were responses of 4-fold increases in antibody titer (hemagglutination inhibition [HI; for influenza virus] and serum bactericidal assay [SBA; for Neisseria meningitides]) for meningococcus and influenza (at least two out of three serotypes), both at 4 weeks postvaccination. All subjects randomized to secukinumab (n = 25) or the control (n = 25) completed the study. Antibody responses to vaccinations measured at 4 weeks were comparable in both groups, with 4-fold increased responses following influenza virus vaccination of 20/25 (80%) for both groups and following meningococcal vaccination of 19/25 (76%) for the secukinumab group and 18/25 (72%) for the control group. Differences between groups were 0% (90% confidence intervals [CI], 19 and 19%) and 4% (90% CI, 16 and 24%) for influenza virus and meningococcal vaccines, respectively. Antibody responses were comparable between the 2 groups at different time points. Headache was the most frequently reported adverse effect. No deaths or serious adverse events were reported. Blockade of IL-17A by secukinumab does not appear to interfere with efficacy of influenza and meningococcal vaccinations, as assessed by the achievement of protective antibody levels. A protective (4-fold) immune response to both vaccinations at 4 weeks was achieved in 80 and 76% of subjects exposed to secukinumab and the control, respectively.
Output: Which molecule is targeted by a monoclonal antibody Secukinumab?
The Cardinals dueled with the Minnesota Vikings for the #3 seed in the NFC playoffs. Things looked bleak for the Cardinals from the beginning. The Vikings began their first quarter attack with an 82-yard punt return for a TD by Bernard Berrian. Two turnovers for the Cardinals, Kurt Warner interception and an Anquan Boldin fumble, would lead to two touchdown passes from Tarvaris Jackson, a 41-yard pass to Berrian and a 19-yard pass to Sidney Rice. The Vikings took a 28-0 lead at halftime after an 11-yard TD pass from Jackson to Chester Taylor. The Cardinals would rally to cut the lead in half with a Jerheme Urban 50-yard TD catch and a field goal blocked by Dominique Rodgers-Cromartie and recovered by Roderick Hood, who returned it 68 yards for a touchdown. The Vikings would pull away at the end of the third quarter when Jackson threw a 59-yard TD pass to Bobby Wade. Kurt Warner was benched on the Cardinals last drive in the fourth quarter via a coaching decision.
Output: Who scored the first touchdown of the game?
After dropping their first four games of the season, the Indianapolis Colts came back to Lucas Oil Stadium to take on the Kansas City Chiefs. The game opened well for the Colts, who scored on their opening drive with a Curtis Painter to Pierre Garcon touchdown reception. In the second quarter, the Colts scored with an Adam Vinatieri field goal and another Painter to Garcon touchdown, giving Indianapolis a 17-0 lead midway through the second quarter. A Kansas City touchdown pass from Matt Cassel ended the shutout but Indianapolis scored another touchdown later. A late Kansas City touchdown allowed the Colts to go into halftime with a 24-14 lead. Two touchdown passes from Cassel, to Dwayne Bowe and Steve Breaston respectively, gave the Chiefs 21 unanswered points and completed the comeback, winning the game 28-24, dropping the Colts to 0-5 on the season.
Output: Who ended the Chiefs shut out?
On July 24, 2017, Gasol re-signed with the Spurs. On December 20, 2017, he had 20 points and a season-high 17 rebounds in a 93-91 win over the Portland Trail Blazers. On December 23, 2017, he recorded his 10th career triple-double with 14 points, 11 rebounds and a season-high 10 assists in a 108-99 win over the Sacramento Kings. On December 26, 2017, in a 109-97 win over the Brooklyn Nets, Gasol collected his 10,817th rebound, moving him past Jack Sikma for 30th in league history. On January 26, 2018, in a 97-78 loss to the Philadelphia 76ers, Gasol became the 34th player in NBA history to play 40,000 career minutes. On March 25, 2018, he had 22 points on 10-of-15 shooting and grabbed 13 rebounds in a 106-103 loss to the Milwaukee Bucks.
Output: Did Gasol's team score more points against the Brooklyn Nets or the Milwaukee Bucks?
The ESET (also called SETDB1) protein contains an N-terminal tudor domain that mediates protein-protein interactions and a C-terminal SET domain that catalyzes methylation of histone H3 at lysine 9. We report here that ESET protein is transiently upregulated in prehypertrophic chondrocytes in newborn mice. To investigate the in vivo effects of ESET on chondrocyte differentiation, we generated conditional knockout mice to specifically eliminate the catalytic SET domain of ESET protein only in mesenchymal cells. Such deletion of the ESET gene caused acceleration of chondrocyte hypertrophy in both embryos and young animals, depleting chondrocytes that are otherwise available to form epiphyseal plates for endochondral bone growth. ESET-deficient mice are thus characterized by defective long bone growth and trabecular bone formation. To understand the underlying mechanism for ESET regulation of chondrocytes, we carried out co-expression experiments and found that ESET associates with histone deacetylase 4 to bind and inhibit the activity of Runx2, a hypertrophy-promoting transcription factor. Repression of Runx2-mediated gene transactivation by ESET is dependent on its H3-K9 methyltransferase activity as well as its associated histone deacetylase activity. In addition, knockout of ESET is associated with repression of Indian hedgehog gene in pre- and early hypertrophic chondrocytes. Together, these results provide clear evidence that ESET controls hypertrophic differentiation of growth plate chondrocytes and endochondral ossification during embryogenesis and postnatal development.
Output: What is the characteristic domain of histone methyltransferases?
When my mother was alive, she used to tell me again and again about the value of just being nice. "Never underestimate the power of a smile," she would say. I fear she would be very disappointed looking at the world today. A lot of people don't smile and when it comes to service today, they're just not nice. Now don't give me wrong, not all service workers but a good many. I was on the phone the other day with a computer help desk. First a man, then later a woman, who couldn't have been ruder. And this to a customer, who didn't know his way around a PC. But no matter, I could tell they thought I was a bother, The woman, in fact, seemed to be chewing gum as she unemotionally clicked off a series of commands for me to perform. The next day I heard from a friend of mine who got a performance review without his boss once looking up at him. Not once. You see it everywhere. Gone are the days when people cared about you. It's a sign of the time, I suspect. But that makes me sad -- for them and for us all. People who aren't happy, who don't smile, who don't kid, who don't joke or make light of even bad situations, make for an even worse situation. And it spreads like a cancer. Someone's rude to you, you're rude to them and to the next fellow you meet, and on and on. Smiles are contagious but so annoyances. The boss who can't be bothered with his workers. The celebrity who can't be bothered with her annoying fans. You know, my mom used to judge presidential candidates by how they smiled. I would say, "But mom, you don't know if that smile is real." "Oh, yes I do," she would tell me. "I can feel it." It's in their eyes, she would say. And it's in their smile. The rest just kind of falls into place.
Output: What's the best title of the passage?
Elis Stromgren's son was the astronomer Bengt Stromgren, who succeeded his father in Copenhagen in 1940.
Output: Who is the offspring of Elis Strömgren?
Rodora is a 1956 movie from Sampaguita Pictures about a man (Juancho Gutierrez) who falls in love with a girl (Amalia Fuentes).
Output: The distributor of Rodora was whom?
As of the census of 2000, there were 120,546 people, 41,668 households, and 32,292 families residing in the county. The population density was 262 people per square mile (101/km). There were 43,903 housing units at an average density of 95 per square mile (37/km). The racial makeup of the county was 68.51% Race (United States Census), 26.06% Race (United States Census) or Race (United States Census), 0.75% Race (United States Census), 1.82% Race (United States Census), 0.06% Race (United States Census), 0.72% from Race (United States Census), and 2.08% from two or more races. 2.26% of the population were Race (United States Census) or Race (United States Census) of any race. 11.6% were of german people, 10.8% irish people, 10.2% english people, 9.3% American and 5.3% italian people ancestry.
Output: Which group from the census is larger: english or italian?
Chronic myeloid leukaemia (CML) is characterized cytogenetically by a t(9;22)(q34;ql1) reciprocal translocation which gives origin to a hybrid BCR-ABL gene, encoding a p2lO(BCR-ABL) fusion protein with elevated tyrosine kinase activity and transforming abilities. The t(9;22) was suggested to be associated with genomic imprinting of centromeric regions of chromosomes 9 and 22, but the genes directly affected by the translocation, ABL and BCR, were shown not to be imprinted. For most diagnostic and research purposes the BCR-ABL gene can be efficiently identified by reverse-transcription and polymerase chain reaction (RT/PCR) amplification of its fusion transcripts, which can be quantified by competitive PCR and similar assays for assessment of residual disease in the follow-up of therapy. In the great majority of CML patients the BCR-ABL transcripts exhibit a b2a2 and/or a b3a2 junction; in rare cases, the only detectable BCR-ABL transcripts have unusual junctions, such as b2a3, b3a3, e1a2 or e6a2. There is a recent suggestion that the BCR-ABL gene may not be always 'functional', since extremely low levels of BCR-ABL transcripts can be found in leucocytes from normal individuals and, conversely, it appears that no BCR-ABL transcription can be detected in a proportion of Ph-positive haematopoietic progenitors from some CML patients. The role, if any, of the reciprocal ABL-BCR hybrid gene in CML is unknown. Although its mRNA message is in frame, no ABL-BCR fusion protein has yet been identified in CML patients. The blast crisis of CML has been variably associated with abnormalities of proto-oncogenes, such as RAS and MYC, or of tumour suppressor genes, in particular RB, p53 and p16, or with the generation of chimeric transcription factors, as in the AML1-EVI1 gene fusion. It is likely, therefore, that multiple and alternative molecular defects, as opposed to a single universal mechanism, underlie the acute transformation of the disease.
Output: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
How fast or slow something moves is its speed. Speed determines how far something travels in a given amount of time. The SI unit for speed is meters per second (m/s). Speed may be constant, but often it varies from moment to moment. Even if speed varies during the course of a trip, its easy to calculate the average speed by using this formula: speed = distance time For example, assume you go on a car trip with your family. The total distance you travel is 120 miles, and it takes 3 hours to travel that far. The average speed for the trip is: 120 mi 3h = 40 mi/h speed = Q: Terri rode her bike very slowly to the top of a big hill. Then she coasted back down the hill at a much faster speed. The distance from the bottom to the top of the hill is 3 kilometers. It took Terri 41 hour to make the round trip. What was her average speed for the entire trip? (Hint: The round-trip distance is 6 km.) A: Terris speed can be calculated as follows: 6 km 0.25 h = 24 km/h speed = When you travel by car, you usually dont move at a constant speed. Instead you go faster or slower depending on speed limits, traffic lights, the number of vehicles on the road, and other factors. For example, you might travel 65 miles per hour on a highway but only 20 miles per hour on a city street (see the pictures in the Figure 1.1.) You might come to a complete stop at traffic lights, slow down as you turn corners, and speed up to pass other cars. Therefore, your speed at any given instant, or your instantaneous speed, may be very different than your speed at other times. Instantaneous speed is much more difficult to calculate than average speed. Cars race by in a blur of motion on an open highway but crawl at a snails pace when they hit city traffic. If you know the average speed of a moving object, you can calculate the distance it will travel in a given period of time or the time it will take to travel a given distance. To calculate distance from speed and time, use this version of the average speed formula given above: distance = speed time For example, if a car travels at an average speed of 60 km/h for 5 hours, then the distance it travels is: distance = 60 km/h 5 h = 300 km To calculate time from speed and distance, use this version of the formula: time = distance speed Q: If you walk 6 km at an average speed of 3 km/h, how much time does it take? A: Use the formula for time as follows: distance speed 6 km = 3 km/h =2h time =
Output: the si unit for speed is