niryuu/sni-each-converted huggingface dataset:
Neurofibromatosis type 1 (NF1) is caused by deletions, insertions, translocations, and point mutations in the NF1 gene, which spans 350 kb on the long arm of human chromosome 17. Although several point mutations have been described, large molecular abnormalities have rarely been characterized in detail. We describe here the molecular breakpoints of a 12-kb deletion of the NF1 gene, which is responsible for the NF1 phenotype in a kindred with two children affected because of germline mosaicism in the unaffected father, who has the mutation in 10% of his spermatozoa. The mutation spans introns 31-39, removing 12,021 nt and inserting 30 bp, of which 19 bp are a direct repetition of a sequence located in intron 31, just 4 bp before the 5' breakpoint. The 5' and 3' breakpoints contain the sequence TATTTTA, which could be involved in the generation of the deletion. The most plausible explanation for the mechanism involved in the generation of this 12-kb deletion is homologous/nonhomologous recombination. Since sperm of the father does not contain the corresponding insertion of the 12-kb deleted sequence, this deletion could have occurred within the NF1 chromosome through loop formation. RNA from lymphocytes of one of the NF1 patients showed similar levels of the mutated and normal transcripts, suggesting that the NF1-mRNA from mutations causing frame shifts of the reading frame or stop codons in this gene is not degraded during its processing. The mutation was not detected in fresh lymphocytes from the unaffected father by PCR analysis, supporting the case for true germ-line mosaicism.
Output: Which is the gene mutated in type 1 neurofibromatosis?
Erythrasma is a skin infection which is caused by Corynebacterium minutissimum. Interdigital erythrasma is the most common form. The aim of this study was to detect the frequency and risk factors of interdigital erythrasma in patients with clinically suspected tinea pedis. This study was conducted between June and December 2010 and included 122 patients who had interdigital foot lesions. All patients were examined using a Wood's lamp. The smears were stained using Gram's method. Direct examination was performed using 20% potassium hydroxide. Sabouraud dextrose agar and brain heart infusion agar were used for cultures. Moreover, the demographical characteristics of patients, concomitant diseases and clinical findings were also recorded. Cases that were found to be positive on Wood's lamp examination and/or Gram staining/culture were considered as erythrasma. The rate of erythrasma was found to be 46.7%. The mean age was 43.6 years, and the disease was more prevalent in men. The most common clinical finding was desquamation. Mycological examination was found as positive in 40.35% of the patients. No growth was observed in bacteriological cultures. It was found that using only Wood's lamp examination or Gram staining resulted in 11 (9%) and 19 positive patients (15.6%), respectively, whereas using both Wood's lamp examination and Gram staining concurrently resulted in 27 positive patients (22.1%). Interdigital erythrasma is a commonly seen condition and can clinically mimic tinea pedis. A Wood's lamp is a good diagnostic tool, but Gram staining, particularly in those with a negative Wood's lamp result, may be a useful method.
Output: Which bacteria causes erythrasma?
Starting lineups: HOUSTON - OFFENSE: QB Matt Schaub, LT Duane Brown, LG Wade Smith, C Chris Myers, RG Mike Brisiel, RT Eric Winston, WR Andre Johnson, RB Arian Foster, FB Vonta Leach, TE Joel Dreessen, WR Kevin Walter.Hoping to snap a four-game losing streak the Texans played on home ground for an AFC South rivalry match against the Titans. The Texans took control throughout the game as QB Matt Schaub got a 1-yard TD pass to TE Joel Dreessen, followed by his 2-yard TD pass to WR Andre Johnson. The lead was increased when kicker Neil Rackers hit a 35 and a 33-yard field goal. With the easy win, the Texans improved to 5-6. However, Johnson was ejected following a fight with Titans CB Cortland Finnegan, who was also ejected.
Output: Which player caught a 2-yard TD pass from Matt Schaub?
This categorises Stahlgewitter in amongst other more historical Rock Against Communism groups such as the English band Skrewdriver which played a lending role in the formation of RAC and the fellow German band Landser who are now deemed a ''criminal gang organisation'' in Germany.
Output: What is the city of origin of Stahlgewitter?
Martial Le Minoux (born 1962) is a French voice actor who specializes in dubbing.
Output: What is the language of Martial Le Minoux?
Carina Massone Negrone (Bogliasco, 20 June 1911 - Bogliasco, 19 March 1991) was an Italian aviator.
Output: Which city was the birthplace of Carina Massone Negrone?
The Ibirapuera Auditorium (Portuguese: Auditorio Ibirapuera) is a building conceived by Oscar Niemeyer for the presentation of musical spectacles, situated in Ibirapuera Park in Sao Paulo.
Output: Which architect was responsible for Ibirapuera Auditorium?
1303 Luthera (1928 FP) is an outer main-belt asteroid discovered on March 16, 1928, by Friedrich Karl Arnold Schwassmann at Hamburg-Bergedorf Observatory.
Output: The inventor of 1303 Luthera was whom?
The Islands of Hawaii Hawaii The "Big Island" of Hawaii is a paradise playground where visitors can enjoy a popular lifestyle and at the same time, witness the attraction of nature: thousands of square miles form a wonderland, featuring breathtaking beaches, forests, snow-covered mountains and amazing active volcanoes. A visit to Volcanoes National Park, which has been described as a true wonder of the world, is a must. It is the state's biggest attraction. Accommodations Seasons Resort Hualalai from $ 205.00Fairmont Orchid: from $108.00 Sightseeing and Experiences Circle Island Tour: from $48.00 Kauai The beautiful landscape of Kauai has led to it being called the "Garden Isle", but it is also referred to as the "Island of discovery", and with good reason - a land of striking natural contrasts just waiting to be explored. Green mountains, a breathtaking coastline and white sand beaches combine to make it one of the world's most relaxing locations. Accommodations Grand Hyatt Kauai: from $ 101.00Sheraton Kauai Resort: from $ 79.00 Maui Voted the "World's Best Island", Maui is widely regarded as one of the most romantic destinations on earth. It is known as the "Valley Isle" and was the ancient playground for Hawaiian royalty. The island is largely rural with a small and wonderful population and a host of attractions and nature wonders. Accommodations Hyatt Regency Maui Resort & Spa: from $ 87.00 Sheraton Maui: from $ 99.00 Oahu Oahu has a unique rhythm, filling the air with sweet fragrances , music and language: from lovely beaches and amazing nightlife to beautiful rainforests and quiet valleys. Adventure, history, romance, discovery--Oahu waits for you. Accommodations Halekulani: from $ 121.00 Hilton Hawaiia: Village: from $ 73.00 Sightseeing and Experiences Royal Circle Island Tour: from $ 34.00 Paradise Cove Lu'au: $ 44.00 # All prices are based on per person per night.
Output: Which island was the ancient playground for Hawaiian royalty?
According to the latest research in the United States,men and women talk such different languages that it is like people from two different cultures trying to communicate.Professor Deborah Tannen of Georgetown University has noticed the difference in the style of boys' and girls' conversations from an early age.She says that little girls' conversation is less definite than boys' and expresses more doubts.Little boys use conversations to establish status with their listeners. These differences continue into adult life,she says.In public conversations,men talk most and interrupt other speakers more.In private conversations,men and women speak in equal amounts--although they say things in a different style.Professor Tannen believes that,for women,private talking is a way to establish and test intimacy(,).For men,private talking is a way to explore the power structure of a relationship. Teaching is one job where the differences between men's and women's ways of talking show.When a man teaches a woman,says Professor Tannen,he wants to show that he has more knowledge,and hence(,)more power in conversation.When a woman teaches another woman,however,she is more likely to take a sharing approach and to encourage her student to join in. But Professor Tannen does not believe that women are naturally more helpful.She says women feel they achieve power by being able to help others.Although the research suggests men talk and interrupt people more than women,Professor Tannen says,women actually encourage this to happen because they believe it will lead to more intimacy and help to establish a relationship. Some scientists who are studying speech think that the brain is pre-programmed for language.As we are usually taught to speak by women,it seems that the brain must have a sexual bias in its programming,otherwise male speech patterns would not arise at all.
Output: In the opinion of the writer,women encourage men to talk more because    .
When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical ingredient but also the product itself. To that end, we applied several relatively standard toxicology study methodologies to female sheep, incorporating an assessment of the pharmacokinetics, safety, tolerability, and local toxicity of a dapivirine-containing human vaginal ring formulation (Dapivirine Vaginal Ring-004). We performed a 3-month general toxicology study, a preliminary pharmacokinetic study using drug-loaded vaginal gel, and a detailed assessment of the kinetics of dapivirine delivery to plasma, vaginal, and rectal fluid and rectal, vaginal, and cervical tissue over 28 days of exposure and 3 and 7 days after removal of the ring. The findings of the general toxicology study supported the existing data from both preclinical and clinical studies in that there were no signs of toxicity related to dapivirine. In addition, the presence of the physical dapivirine ring did not alter local or systemic toxicity or the pharmacokinetics of dapivirine. Pharmacokinetic studies indicated that the dapivirine ring produced significant vaginal tissue levels of dapivirine. However, no dapivirine was detected in cervical tissue samples using the methods described here. Plasma and vaginal fluid levels were lower than those in previous clinical studies, while there were detectable dapivirine levels in the rectal tissue and fluid. All tissue and fluid levels tailed off rapidly to undetectable levels following removal of the ring. The sheep represents a very useful model for the assessment of the safety and pharmacokinetics of microbicide drug delivery devices, such as the vaginal ring.
Output: Which infection can be prevented with Dapivirine?
April 11, 2003 12:44 a. m. PST, Associated Press The respiratory virus known as SARS has appeared to spread in the United States only to family members of health workers with close contact to a sick person. On Thursday, the head of the Centers for Disease Control and Prevention said there might be a case of severe acute respiratory syndrome spreading through the workplace. Dr. Julie Gerberding said a suspected SARS virus patient who became ill after traveling to Asia might have infected a co-worker in Florida, which made her "very worried". So far, a dozen people--nine family members and three health workers--were infected after coming into close contact with the person with SARS. The rest of the 166 suspected American cases have something to do with people who were infected while traveling in Asia. In the Gainesville, Fla. area, a 47-year-old woman was believed to have been infected at work by a 60-year-old woman who was the nation's first suspected SARS case, said Tom Belcuore, director of the Alachua County health department. Since the World Health Organization announced a worldwide warning last month about SARS, the United States has started infection control in hospitals and among families of suspected cases. Florida officials said a school in Okaloosa County went through a cleaning after a 6-year-old boy suspected of having SARS appeared at school with slight symptoms. "Health officials are watching the boys' contacts at school to make sure no one else is infected," said Rob Hayes, health department spokesman, "The boy may have been infected from a family member," Hayes said, "We immediately became aware of it and had the child sent home. He's staying at home with his family until 10 days after symptoms disappear." The researchers guessed that the virus might have come from animals. However, the scientists have not ruled out the possibility that some other microbe might also help make SARS more serious or easier to catch.
Output: How many cases of suspected SARS are there in the U.S.A. according to the text?
The IUCN Redlist 3.1, which uses the Birdlife International checklist, lumps the common and widespread grey-headed parrot with Cape parrots and brown-necked parrots, each of which are more narrowly distributed and more threatened, leading to an assessment of least concern.
Output: What is the status of Cape parrot?
Elizabeth Jeffries (1727, Bridgnorth, Shropshire -- March 28, 1752 in Leytonstone, England) was an English woman executed for murder.
Output: Which crime led to the conviction of Elizabeth Jeffries?
German submarine U-331 was a Type VIIC U-boat of Nazi Germany's Kriegsmarine during World War II. The submarine was laid down on 26 January 1940 at the Nordseewerke yard at Emden, launched on 20 December 1940, and commissioned on 31 March 1941 under the command of Oberleutnant zur See Hans-Diedrich Freiherr von Tiesenhausen.
Output: What company made German submarine U-331?
William of Newburgh or Newbury (Latin: Guilelmus Neubrigensis, Wilhelmus Neubrigensis, or Willelmus de Novoburgo. 1136?--1198?), also known as William Parvus, was a 12th-century English historian and Augustinian canon of Anglo-Saxon descent from Bridlington, Yorkshire.
Output: What is the nationality of birth of William of Newburgh?
Louis Lacombe was born in Bourges, the brother of composer Felicita Casella.
Output: Who is Louis Lacombe's sister?
A common misconception is that the Sun is closer to Earth in the summer and farther away from it during the winter. Instead, the seasons are caused by the 23.5o tilt of Earths axis of rotation relative to its plane of orbit around the Sun (Figure 1.1). Solstice refers to the position of the Sun when it is closest to one of the poles. At summer solstice, June 21 or 22, Earths axis points toward the Sun and so the Sun is directly overhead at its furthest north point of the year, the Tropic of Cancer (23.5o N). During the summer, areas north of the Equator experience longer days and shorter nights. In the Southern Hemi- sphere, the Sun is as far away as it will be and so it is their winter. Locations will have longer nights and shorter days. The opposite occurs on winter solstice, which begins on December 21. More about seasons can be found in the Atmospheric Processes chapter. Different parts of the Earth receive different amounts of solar radiation. Which part of the planet receives the most solar radiation? The Suns rays strike the surface most directly at the Equator. Different areas also receive different amounts of sunlight in different seasons. What causes the seasons? The seasons are caused by the direction Earths axis is pointing relative to the Sun. The Earth revolves around the Sun once each year and spins on its axis of rotation once each day. This axis of rotation is tilted 23.5o relative to its plane of orbit around the Sun. The axis of rotation is pointed toward Polaris, the North Star. As the Earth orbits the Sun, the tilt of Earths axis stays lined up with the North Star. The North Pole is tilted towards the Sun and the Suns rays strike the Northern Hemisphere more directly in summer (Figure 1.2). At the summer solstice, June 21 or 22, the Suns rays hit the Earth most directly along the Tropic of Cancer (23.5o N); that is, the angle of incidence of the Suns rays there is zero (the angle of incidence is the deviation in the angle of an incoming ray from straight on). When it is summer solstice in the Northern Hemisphere, it is winter solstice in the Southern Hemisphere. Winter solstice for the Northern Hemisphere happens on December 21 or 22. The tilt of Earths axis points away from the Sun (Figure 1.3). Light from the Sun is spread out over a larger area, so that area isnt heated as much. With fewer daylight hours in winter, there is also less time for the Sun to warm the area. When it is winter in the Northern Hemisphere, it is summer in the Southern Hemisphere. Halfway between the two solstices, the Suns rays shine most directly at the Equator, called an equinox (Figure 1.4). The daylight and nighttime hours are exactly equal on an equinox. The autumnal equinox happens on September 22 or 23 and the vernal, or spring, equinox happens March 21 or 22 in the Northern Hemisphere. Summer solstice in the Northern Hemisphere. Click image to the left or use the URL below. URL:
Output: this refers to when the position of the sun is closest to one of the poles.
SECIS elements are stem-loop structures located in the 3' untranslated regions (UTRs) of eukaryotic selenoprotein mRNAs that are required for directing cotranslational selenocysteine incorporation at UGA codons. In prokaryotes, stem-loops mediating selenocysteine incorporation are located immediately downstream of the UGA selenocysteine codon, in the coding region. Previous characterization studies of the mammalian SECIS elements of type 1 deiodinase, glutathione peroxidase, and selenoprotein P showed that conserved nucleotides in the loops and unpaired bulges, and base pairing in the stems are required for SECIS function. These initial studies utilized approximately 175-230-nt segments of the 3'UTRs of the selenoprotein mRNAs. Here we define the minimal functional rat type 1 deiodinase SECIS element, a 45-nt segment, the 5' boundary of which corresponds precisely to the 5'-most critical conserved nucleotide identified previously. We also define base pairing requirements in the stem of this element. In view of the presence of SECIS elements in the open reading frames (ORFs) of bacterial selenoproteins, we examine the effects in the type 1 deiodinase of extending the ORF into the SECIS element, and find that this dramatically inhibits SECIS function. Finally, we define a minimal spacing requirement of 51-111 nt between a eukaryotic UGA selenocysteine codon and SECIS element.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Haploinsufficiency of the NSD1 gene due to 5q35 microdeletions or intragenic mutations is the major cause of Sotos syndrome characterized by generalized overgrowth, large hands and feet with advanced bone age, craniofacial dysmorphic features, learning disability, and possible susceptibility to tumors. Here, we report on a 14-month-old boy with a reverse phenotype of Sotos syndrome due to the reciprocal duplication of the 5q35.3 region, including the NSD1 gene, detected by array CGH. The phenotype includes delayed bone age, microcephaly, seizures, and failure to thrive. Our case suggests that the gene dosage effect of the NSD1 gene is the likely cause for the reversed phenotype of Sotos syndrome in this patient.
Output: Which gene is responsible for the development of Sotos syndrome?
Muppet Monster Adventure is a platform game for the Sony PlayStation developed by Magenta Software and Jim Henson Interactive in 2000, and published by Sony Computer Entertainment in Europe and Midway Home Entertainment in North America.
Output: What is the name of Muppet Monster Adventure's developer?
Some aquifers are overused; people pump out more water than is replaced. As the water is pumped out, the water table slowly falls, requiring wells to be dug deeper, which takes more money and energy. Wells may go completely dry if they are not deep enough to reach into the lowered water table. Other problems may stem from groundwater overuse. Subsidence and saltwater intrusion are two of them. The Ogallala Aquifer supplies about one-third of the irrigation water in the United States. The Ogallala Aquifer is widely used by people for municipal and agricultural needs. (Figure 1.2). The aquifer is found from 30 to 100 meters deep over an area of about 440,000 square kilometers! The water in the aquifer is mostly from the last ice age. About eight times more water is taken from the Ogallala Aquifer each year than is replenished. Much of the water is used for irrigation (Figure 1.3). Click image to the left or use the URL below. URL: Intense drought has reduced groundwater levels in the southern U.S., particularly in Texas and New Mexico. Lowering the water table may cause the ground surface to sink. Subsidence may occur beneath houses and other structures (Figure 1.4). When coastal aquifers are overused, salt water from the ocean may enter the aquifer, contaminating the aquifer and making it less useful for drinking and irrigation. Salt water incursion is a problem in developed coastal regions, such as on Hawaii.
Output: this aquifer supplies one-third of the irrigation water in the united states.
Hampton Coliseum was one of several former homes of the American Basketball Association Virginia Squires professional basketball franchise .
Output: What team uses Hampton Coliseum?
To define the relationship between body indices of healthy adults and cross-sectional areas of the carpal tunnel and median nerve and to obtain the nerve/tunnel index, which represents a new standard for diagnosing carpal tunnel syndrome using sonography. Body indices (height, weight, and body mass index) were analyzed in 60 healthy adults, and electromyography and sonography were also performed. The cross-sectional areas of the proximal and distal median nerve and carpal tunnel were obtained by sonography. The proximal and distal nerve/tunnel indices were obtained by calculating the ratio between the proximal and distal cross-sectional areas of the median nerve to those of the carpal tunnel and multiplying the value by 100. Although the proximal cross-sectional areas of the median nerve and body indices showed statistically significant relationships with weak positive correlations, the proximal and distal areas of the carpal tunnel showed relatively stronger correlations with body indices. Between sexes, there were significant differences in the proximal median nerve cross-sectional area (mean SD: male, 10.48 3.21 mm(2); female, 8.81 3.21 mm(2); P < .05) and proximal carpal tunnel area (male, 182.50 21.15 mm(2); female, 151.23 21.14 mm(2); P < .05). There was no difference in the proximal nerve/tunnel index (male, 5.80% 1.72%; female, 5.91% 1.63%). There was a statistically significant difference in the distal carpal tunnel cross-sectional area (male, 138.90 20.95 mm(2); female, 121.50 18.99 mm(2); P < .05) between sexes, but the distal median area (male, 9.99 3.42 mm(2); female, 8.46 1.84 mm(2)) and distal nerve/tunnel index (male, 7.15% 2.00%; female, 7.01% 1.38%) showed no significant differences. The proximal index was significantly higher than the distal index (proximal, 5.85% 1.66%; distal, 7.08% 1.71%). The nerve/tunnel index is unaffected by body indices or sex and thus may be a useful and objective standard for diagnosing carpal tunnel syndrome.
Output: What nerve is involved in carpal tunnel syndrome?
Simtek Grand Prix, the racing team, launched in 1993 and competed in the 1994 and 1995 seasons achieving a best result of ninth place.
Output: On what date did Simtek end?
It is generally accepted that the mitochondria play central roles in energy production of most eukaryotes. In contrast, it has been thought that Plasmodium spp., the causative agent of malaria, rely mainly on cytosolic glycolysis but not mitochondrial oxidative phosphorylation for energy production during blood stages. However, Plasmodium spp. possesses all genes necessary for the tricarboxylic acid (TCA) cycle and most of the genes for electron transport chain (ETC) enzymes. Therefore, it remains elusive whether oxidative phosphorylation is essential for the parasite survival. To elucidate the role of TCA metabolism and ETC in malaria parasites, we deleted the gene for flavoprotein (Fp) subunit, Pbsdha, one of four components of complex II, a catalytic subunit for succinate dehydrogenase activity. The Pbsdha(-) parasite grew normally at blood stages in mouse. In contrast, ookinete formation of Pbsdha(-) parasites in the mosquito stage was severely impaired. Finally, Pbsdha(-) ookinetes failed in oocyst formation, leading to complete malaria transmission blockade. These results suggest that malaria parasite may switch the energy metabolism from glycolysis to oxidative phosphorylation to adapt to the insect vector where glucose is not readily available for ATP production.
Output: Which is the causative agent of malaria?
Ayhan Tuna Uzumcu (born 6 August 1982) is a Turkish football defender, who plays for Adanaspor.
Output: What position did Tuna Üzümcü play in football?
A sense of humor is just one of the many things shared by Alfred and Anthony Melillo, 64-year-old twin brothers from East Haven who made history in February 2002. On Christmas Eve, 1992, Anthony had a heart transplant from a 21-year-old donor. Two days before Valentine's Day in 2002, Alfred received a 19-year-old heart, marking the first time on record that twin adults each received heart transplants. "I'm 15 minutes older than him, but now I'm younger because of my heart and I'm not going to respect him," Alfred said with a big smile, pointing to his brother while talking to a roomful of reporters, who laughed frequently at their jokes. While the twins knew that genetics might have played a role in their condition, they recognized that their eating habits might have also contributed to their heart problems. "We'd put half a pound of butter on a steak. I overdid it on all the food that tasted good, so I guess I deserved what I got for not dieting properly." The discussion moved to Anthony's recovery. In the five years since his heart transplant, he had been on an exercise program where he regularly rode a bicycle for five miles, swam each day, and walked a couple of miles. He was still on medication, but not nearly as much as Alfred, who was just in the early stage of his recovery. "Right now I feel pretty young and I'm doing very well," Anthony said. "I feel like a new person." Alfred said his goal, of course, was to feel even better than his brother. But, he added, "I love my brother very much. We're very close and I'm sure we'll do just fine."
Output: What did Alfred and Anthony have in common?
The police must investigate a series of robberies along a strip of land in the city. The new mayor of the city (Kenneth Mars) assigns Captain Harris (G.W. Bailey) and Lt. Proctor (Lance Kinsey) to the case, but while on stakeout the Wilson gang manages to slip through their fingers.The Mayor wants Harris and Proctor to work with Police Academy head Commandant Lassard (George Gaynes) on apprehending the gang. Lassard assembles a seven-man team consisting of Hightower (Bubba Smith), Tackleberry (David Graf), Jones (Michael Winslow), Hooks (Marion Ramsey), Callahan (Leslie Easterbrook), Fackler (Bruce Mahler), and Lassard's nephew, Nick (Matt McCoy) who transfers from Miami (in the previous film Police Acdemy 5) to the city to remain close to his friends and dull-witted uncle.After distributing flyers as to the information of the Wilson gang and getting nowhere, Nick McCoy stumbles upon a paper heading of an antique diamond heading to a museum, and gets an idea to use it as bait: however the robbers nab the diamond anyway by cutting a hole in the truck and escaping through the sewer system. McCoy then decides to go undercover to get information regarding a possible hideout, but Harris decides to go undercover to get a confession.It turns out that Harris goes undercover as a window washer at a tall building, for which he has a fear of heights, and gets a confession of himself on tape after his loyal but numb-skull lacky, Proctor, accidentally knocks him over the balcony.It is revealed here that the robberies are committed by a group of three dim-witted criminals who do not seem to be able to do this on their own, and it is revealed they are being guided by a literally shadow figure known as the "Mastermind", who speaks to the three behind a wall of glass and uses a voice distortion device. He devises a plan to get the cops out of the way.Commandant Lassard and his men are later suspended after stolen jewellery from the last robbery is planted in Lassard's locker, pending an investigation. The misfit cops decide to clear Lassard's name by nabbing the gang and the ringleader. Accessing data files from a computer, McCoy deduces that the robberies are occurring along a bus route, thus intentionally lowering property values in that part of the city. They also learn that someone must be 'leaking' information to the bad guys, which is why they are always one step ahead of the Police Academy.The Police Academy force finds and does battle with the Wilson gang, while Nick chases the leader. A pursuit follows, which leads to Commissioner Hurst's (George Robertson) office. It is revealed that the Mayor is the "Mastermind" and that Captain Harris has been unwittingly leaking information during his daily meetings with the Mayor. Hurst apologizes and reinstates the force, and a plaque is given to honor the officers' bravery the next day.As the movie closes, Harris is sitting in a chair when a string tying the balloon float is cut, lifting his chair and floating him up into the air as he shouts Proctor's name.
Output: What is given to honor the officers bravery the next day ?
I will always remember my mother's last days in this world. On February 14th, 2008, my class went on a field trip to the beach. I had so much fun. When we returned to school, my teacher told me to go to the headmaster's office. When I got into the office, I saw a police officer. Suddenly, I realized something was wrong. The police officer told me what had happened and we went to pick my sister up. After that, we went to the hospital and waited. Time went slowly. Finally, we got to see our mother. It was terrible. On the next day, the headmaster came and told my two teachers what had happened. I was taking a test that day. I knew it had something to do with my mother. I kept thinking that she either died or had gotten better. How I wished that she had gotten better. When my teacher took me outside, my sister ran up to me. She started crying, "She's gone, Terresa, mommy's gone. She's dead." I couldn't believe it. We jumped into the car and drove straight to the hospital. Most of my family were there. The silence was terrible. I knew I had to say goodbye. Today when I look back, I still miss my mother very much, but I know that I will live. My mother was a strong mother, who had the biggest heart. She was an angel walking on the earth. I will always remember her as a living. When someone is asked who their hero is, they usually say someone famous, like Michael Jordan or Britney Spears. When someone asks me who my hero is, I tell them, my mother. My mother lives everyday. That is what makes her a true hero.
Output: Who brought the writer the bad news that her mother was ill?
Sir Thomas Lea, 1st Baronet (17 January 1841 -- 9 January 1902) was an English carpet manufacturer from Kidderminster, and a Liberal Party politician.
Output: What nationality is Sir Thomas Lea, 1st Baronet?
Kleinmann's tortoise (Testudo kleinmanni ), often called the Egyptian tortoise and occasionally Leith's tortoise, is a critically endangered species of neck-hiding tortoise.
Output: What level is Kleinmann's tortoise's iucn conservation status?
The reactive oxygen-generating NADPH oxidases (Noxes) function in a variety of biological roles, and can be broadly classified into those that are regulated by subunit interactions and those that are regulated by calcium. The prototypical subunit-regulated Nox, Nox2, is the membrane-associated catalytic subunit of the phagocyte NADPH-oxidase. Nox2 forms a heterodimer with the integral membrane protein, p22phox, and this heterodimer binds to the regulatory subunits p47phox, p67phox, p40phox and the small GTPase Rac, triggering superoxide generation. Nox-organizer protein 1 (NOXO1) and Nox-activator 1 (NOXA1), respective homologs of p47phox and p67phox, together with p22phox and Rac, activate Nox1, a non-phagocytic homolog of Nox2. NOXO1 and p22phox also regulate Nox3, whereas Nox4 requires only p22phox. In this study, we have assembled and analyzed amino acid sequences of Nox regulatory subunit orthologs from vertebrates, a urochordate, an echinoderm, a mollusc, a cnidarian, a choanoflagellate, fungi and a slime mold amoeba to investigate the evolutionary history of these subunits. Ancestral p47phox, p67phox, and p22phox genes are broadly seen in the metazoa, except for the ecdysozoans. The choanoflagellate Monosiga brevicollis, the unicellular organism that is the closest relatives of multicellular animals, encodes early prototypes of p22phox, p47phox as well as the earliest known Nox2-like ancestor of the Nox1-3 subfamily. p67phox- and p47phox-like genes are seen in the sea urchin Strongylocentrotus purpuratus and the limpet Lottia gigantea that also possess Nox2-like co-orthologs of vertebrate Nox1-3. Duplication of primordial p47phox and p67phox genes occurred in vertebrates, with the duplicated branches evolving into NOXO1 and NOXA1. Analysis of characteristic domains of regulatory subunits suggests a novel view of the evolution of Nox: in fish, p40phox participated in regulating both Nox1 and Nox2, but after the appearance of mammals, Nox1 (but not Nox2) became independent of p40phox. In the fish Oryzias latipes, a NOXO1 ortholog retains an autoinhibitory region that is characteristic of mammalian p47phox, and this was subsequently lost from NOXO1 in later vertebrates. Detailed amino acid sequence comparisons identified both putative key residues conserved in characteristic domains and previously unidentified conserved regions. Also, candidate organizer/activator proteins in fungi and amoeba are identified and hypothetical activation models are suggested. This is the first report to provide the comprehensive view of the molecular evolution of regulatory subunits for Nox enzymes. This approach provides clues for understanding the evolution of biochemical and physiological functions for regulatory-subunit-dependent Nox enzymes.
Output: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Lever House, designed by Gordon Bunshaft and Natalie de Blois (design coordinator) of Skidmore, Owings and Merrill and located at 390 Park Avenue in Midtown Manhattan, New York City, is a seminal glass-box skyscraper built in the International Style according to the design principles of Ludwig Mies van der Rohe.
Output: Who was the architect or designer of Lever House?
Oil is a liquid fossil fuel that is extremely useful because it can be transported easily and can be used in cars and other vehicles. Oil is currently the single largest source of energy in the world. Oil from the ground is called crude oil, which is a mixture of many different hydrocarbons. Crude oil is a thick dark brown or black liquid hydrocarbon. Oil also forms from buried dead organisms, but these are tiny organisms that live on the sea surface and then sink to the seafloor when they die. The dead organisms are kept away from oxygen by layers of other dead creatures and sediments. As the layers pile up, heat and pressure increase. Over millions of years, the dead organisms turn into liquid oil. In order to be collected, the oil must be located between a porous rock layer and an impermeable layer (Figure 1.1). Trapped above the porous rock layer and beneath the impermeable layer, the oil will remain between these layers until it is extracted from the rock. Oil (red) is found in the porous rock layer (yellow) and trapped by the impermeable layer (brown). The folded structure has allowed the oil to pool so a well can be drilled into the reservoir. To separate the different types of hydrocarbons in crude oil for different uses, the crude oil must be refined in refineries like the one shown in Figure 1.2. Refining is possible because each hydrocarbon in crude oil boils at a different temperature. When the oil is boiled in the refinery, separate equipment collects the different compounds. Most of the compounds that come out of the refining process are fuels, such as gasoline, diesel, and heating oil. Because these fuels are rich sources of energy and can be easily transported, oil provides about 90% of the energy used for transportation around the world. The rest of the compounds from crude oil are used for waxes, plastics, fertilizers, and other products. Gasoline is in a convenient form for use in cars and other transportation vehicles. In a car engine, the burned gasoline mostly turns into carbon dioxide and water vapor. The fuel releases most of its energy as heat, which causes the gases to expand. This creates enough force to move the pistons inside the engine and to power the car. Refineries like this one separate crude oil into many useful fuels and other chemi- cals. Click image to the left or use the URL below. URL: The United States does produce oil, but the amount produced is only about one-quarter as much as the nation uses. The United States has only about 1.5% of the worlds proven oil reserves, so most of the oil used by Americans must be imported from other nations. The main oil-producing regions in the United States are the Gulf of Mexico, Texas, Alaska, and California (Figure As in every type of mining, mining for oil has environmental consequences. Oil rigs are unsightly (Figure 1.4), and spills are too common (Figure 1.5). Click image to the left or use the URL below. URL: Offshore well locations in the Gulf of Mex- ico. Note that some wells are located in very deep water. Drill rigs at the San Ardo Oil Field in Monterey, California.
Output: crude oil is a mixture of many different
Snow Wolf is an espionage novel by Glenn Meade.
Output: Who wrote the Snow Wolf?
Facio-scapulo-humeral dystrophy (FSHD) results from deletions in the subtelomeric macrosatellite D4Z4 array on the 4q35 region. Upregulation of the DUX4 retrogene from the last D4Z4 repeated unit is thought to underlie FSHD pathophysiology. However, no one knows what triggers muscle defect and when alteration arises. To gain further insights into the molecular mechanisms of the disease, we evaluated at the molecular level, the perturbation linked to the FSHD genotype with no a priori on disease onset, severity or penetrance and prior to any infiltration by fibrotic or adipose tissue in biopsies from fetuses carrying a short pathogenic D4Z4 array (n = 6) compared with fetuses with a non-pathogenic D4Z4 array (n = 21). By measuring expression of several muscle-specific markers and 4q35 genes including the DUX4 retrogene by an RT-PCR and western blotting, we observed a global dysregulation of genes involved in myogenesis including MYOD1 in samples with <11 D4Z4. The DUX4-fl pathogenic transcript was detected in FSHD biopsies but also in controls. Importantly, in FSHD fetuses, we mainly detected the non-spliced DUX4-fl isoform. In addition, several other genes clustered at the 4q35 locus are upregulated in FSHD fetuses. Our study is the first to examine fetuses carrying an FSHD-linked genotype and reveals an extensive dysregulation of several muscle-specific and 4q35 genes at early development stage at a distance from any muscle defect. Overall, our work suggests that even if FSHD is an adult-onset muscular dystrophy, the disease might also involve early molecular defects arising during myogenesis or early differentiation.
Output: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
Night 'n' Gales is a 1937 Our Gang short comedy film directed by Gordon Douglas.
Output: Night 'n' Gales a 2001 german drama film directed by ?
In June 1220, Emperor Frederick II elevated Pfullendorf to the status of Imperial City.
Output: What was the inception year of Pfullendorf?
Mutations of presenilin 1 (PS1) causing Alzheimer's disease selectively increase the secretion of the amyloidogenic betaA4(1-42), whereas knocking out the gene results in decreased production of both betaA4(1-40) and (1-42) amyloid peptides (De Strooper et al. 1998). Therefore, PS1 function is closely linked to the gamma-secretase processing of the amyloid precursor protein (APP). Given the ongoing controversy on the subcellular localization of PS1, it remains unclear at what level of the secretory and endocytic pathways PS1 exerts its activity on APP and on the APP carboxy-terminal fragments that are the direct substrates for gamma-secretase. Therefore, we have reinvestigated the subcellular localization of endogenously expressed PS1 in neurons in vitro and in vivo using confocal microscopy and fine-tuned subcellular fractionation. We show that uncleaved PS1 holoprotein is recovered in the nuclear envelope fraction, whereas the cleaved PS fragments are found mainly in post-ER membranes including the intermediate compartment (IC). PS1 is concentrated in discrete sec23p- and p58/ERGIC-53-positive patches, suggesting its localization in subdomains involved in ER export. PS1 is not found to significant amounts beyond the cis-Golgi. Surprisingly, we found that APP carboxy-terminal fragments also coenrich in the pre-Golgi membrane fractions, consistent with the idea that these fragments are the real substrates for gamma-secretase. Functional evidence that PS1 exerts its effects on gamma-secretase processing of APP in the ER/IC was obtained using a series of APP trafficking mutants. These mutants were investigated in hippocampal neurons derived from transgenic mice expressing PS1wt or PS1 containing clinical mutations (PS1(M146L) and PS1(L286V)) at physiologically relevant levels. We demonstrate that the APP-London and PS1 mutations have additive effects on the increased secretion of betaA4(1-42) relative to betaA4(1-40), indicating that both mutations operate independently. Overall, our data clearly establish that PS1 controls gamma(42)-secretase activity in pre-Golgi compartments. We discuss models that reconcile this conclusion with the effects of PS1 deficiency on the generation of betaA4(1-40) peptide in the late biosynthetic and endocytic pathways.
Output: Which disease the London mutation involved in?
The Story of Tracy Beaker is a British children's book first published in 1991, written by Jacqueline Wilson and illustrated by Nick Sharratt.
Output: Who was The Story of Tracy Beaker illustrated by?
Lighter and cheaper than high-quality video cameras, today's best smartphones can shoot and edit high-definition (HD) videos. With lower-quality lenses and image sensors, smartphones probably won't replace professional video cameras anytime soon. Still, some creative filmmakers are extending the borders of smartphone moviemaking by shooting professional-quality films using only smartphones. Soon after Apple's iPhone 4 was released, two filmmakers decided to make a short film using only their iPhone 4s. Michael Koerbel and Anna Elizabeth James shot and edited the one-and-a-half-minute film Apple of My Eye in only 48 hours. Audiences were fascinated with the film, in which a man and his grandfather connect emotionally while admiring a model train set in a store window. The filmmakers followed up their success with Goldilocks, an extraordinary spy novel told over nine, three-minute films. Many filmmakers are convinced that smartphone films are here to stay. One sign is their inclusion in major film festivals. In February 2012, organizers of the Berkshire International Film Festival staged the 10 X 10 On North Festival. Entries included Oliver by Hooman Khalili, an award-winning film about a girl whose special powers enable her to brighten the lives of three lonely people. Another entry was Yearlapse'11, a 365-second film by Zsolt Haraszti that describes an actual journey he made from New York to London. During the festival, which ran from February 16 to 26, these and many other smartphone films were shown at the Beacon Cinema in Pittsfield, Massachusetts. Similar festivals in Canada and South Korea have given smartphone filmmakers opportunities to show off their creative work.
Output: Which film is about secret agents?
The Browns were making their first trip to San Diego since 2006. The game was back and forth, with neither team leading by more than one possession. The Chargers led 7-3 after the 1st quarter. On the Browns' first drive of the second quarter, QB Josh McCown threw a 34-yard touchdown pass to RB Duke Johnson to put the Browns up 10-7. The teams traded field goals, making it a 13-13 game at halftime. The Browns scored a field goal at the start of the 3rd quarter to go up 16-13. On the Chargers' next drive, QB Philip Rivers led the Chargers to a touchdown, going up 20-16 heading into the 4th quarter. After K Travis Coons kicked a field goal to cut the deficit to 20-19, Rivers led another touchdown drive to put the Chargers up 27-19. On the Browns' next drive, they reached the end zone, assisted by an incredible catch by TE Gary Barnidge on the Chargers' 1 yard line. They converted on the two point conversion to tie the game at 27-27 with just over 2 minutes remaining. The Chargers reached the Browns' 24 yard line with under 50 seconds to play. The Browns began to use timeouts until the Chargers faced 4th down with 2 seconds to play. After the Chargers called timeout, their kicker had an opportunity to win the game with a 39-yard field goal. The 39 yard game winning attempt was off to the right, and the game appeared to be on its way to overtime.. However, CB Tramon Williams was flagged for being offside during the play, giving the Chargers another attempt, this time from 34 yards. The field goal was converted, and the Chargers won 30-27. The Browns committed 12 penalties in the game, including this critical offside penalty.
Output: A field goal from an unknown distance was made by who?
Haiti is the mountain range ''Hait'', and New York City becomes the ruins of ''Niourk''.
Output: Which place does Niourk exist in?
Simon Miller (Loren Dean) outwardly appears to be a geologist who must frequently take business trips, which has strained the relationship with his family, including his wife Meredith (Robyn Lively) and teenage children Sarah (Skyler Day) and Kevin (Drew Koles). When Simon suddenly goes missing, his family searches his office and discovers several passports, each with different aliases. They soon learn that Simon was in fact a spy who kept his true career secret from them. Simon mysteriously calls home and warns his family not to tell anyone about his disappearances, then abruptly hangs up. His family begins a search for Simon, which takes them to locations around the world. Sarah, an honor student, uses her foreign language skills to help, and Kevin uses his knowledge of technology.[1] They receive assistance from Amanda (Christine Baranski), another covert operative who initially appears to be a friend, but appears to have her own motives.[2]
Output: What do they find in Simon's office?
Ranx the Sentient City appears in DC Universe Online.
Output: What is the fictional universe that Ranx the Sentient City belong to?
Seiffert Oval is a rugby league ground in Queanbeyan, New South Wales that served as the base of the Canberra Raiders for the first seven years of its existence (1982-1989).
Output: What team uses Seiffert Oval?