niryuu/sni-each-converted huggingface dataset:
There are about 27,000 species of bony fish ( Figure 1.1), which are divided into two classes: ray-finned fish and lobe-finned fish. Most bony fish are ray-finned. These thin fins consist of webs of skin over flexible spines. Lobe- finned fish, on the other hand, have fins that resemble stump-like appendages. Fins of bony fish: ray fin (left) and lobe fin (right). Most fish are bony fish, making them the largest group of vertebrates in existence today. They are characterized by: 1. A head and pectoral girdles (arches supporting the forelimbs) that are covered with bones derived from the skin. 2. A lung or swim bladder, which helps the body create a balance between sinking and floating by either filling up with or emitting gases such as oxygen. Controlling the volume of this organ helps fish control their depth. 3. Jointed, segmented rods supporting the fins. 4. A cover over the gill called the operculum, which helps them breathe without having to swim. 5. The ability to see in color, unlike most other fish. Most vertebrates are ray-finned fish, with close to 27,000 known species. By comparison, there are "only" about 10,000 species of birds. The ray-finned fish have fin rays, with fins supported by bony spines known as rays. The ray-finned fish are the dominant class of vertebrates, with nearly 99% of fish falling into this category. They live in all aquatic environments, from freshwater and marine environments from the deep sea to the highest mountain streams. The lobe-finned fish are characterized by fleshy lobed fins, as opposed to the bony fins of the ray-finned fish. There are two types of living lobe-finned fish: the coelacanths and the lungfish. The pectoral and pelvic fins have joints resembling those of tetrapod (four-limbed land vertebrates) limbs. These fins evolved into legs of amphibians, the first tetrapod land vertebrates. They also possess two dorsal fins with separate bases, as opposed to the single dorsal fin of ray-finned fish. All lobe-finned fishes possess teeth covered with true enamel. The lungfish also possess both gills and lungs, solidifying this class as the ancestors of amphibians. The ocean sunfish is the most massive bony fish in the world, up to 11 feet long and weighing up to 5,070 pounds ( Figure 1.2). Other very large bony fish include the Atlantic blue marlin, the black marlin, some sturgeon species, the giant grouper, and the goliath grouper. The long-bodied oarfish can easily be over 30 feet long, but is not nearly as massive as the ocean sunfish. In contrast, the dwarf pygmy goby measures only 0.6 inches. Fish can also be quite valuable. In January 2013, at an auction in Tokyos Tsukiji fish market, a 222-kilogram (489-pound) tuna caught off northeastern Japan sold for 155.4 million yen, which is $1,760,000. An ocean sunfish, the most massive bony fish in the world, can reach up to 11 feet long and weigh up to 5,070 pounds!
Output: most fish are what type?
Sedation is an important aspect of care for critically ill newborns. Proper sedation reduces stress during procedures such as mechanical ventilation. Midazolam, a short-acting benzodiazepine, is widely administered as a sedative in newborn intensive care units but is not without side effects. Three term newborns developed myoclonic-like abnormal movements after receiving midazolam. In one, flumazenil controlled the abnormal movements. Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines. It can reverse the sedative effects of benzodiazepines occurring after diagnostic or therapeutic procedures or after benzodiazepine overdose. Flumazenil may be considered in cases of abnormal movements associated with midazolam. However, further studies are needed to provide guidelines for the administration of this drug in newborns.
Output: Which drug should be used as an antidote in benzodiazepine overdose?
It is headquartered at the Fiji Link office in the Civil Aviation Authority of Fiji (CAAFI) compound at Nadi International Airport in Nadi, Fiji.
Output: What is the name of the airport associated with Fiji Link?
The H-IIB rocket with Kounotori 2 onboard was successfully launched from Tanegashima Space Center on 22 January 2011, 05:37:57 UTC.
Output: What date was Kounotori 2 launched?
By 1759, Alaungpaya had reunified all of Burma plus Manipur and Lan Na. However, his hold on Lan Na and Tenasserim coast was still nominal. The Siamese who originally were concerned about the rising power of Restored Hanthawaddy now actively supported the ethnic Mon rebels operating in the upper Tenasserim coast. In December 1759, Alaungpaya and his 40,000-strong armies invaded the Tenasserim coast. They crossed over the Tenasserim Hills, and finally reached Ayutthaya on 11 April 1760. But only five days into the siege, the Burmese king suddenly fell ill and the Burmese withdrew. The king died three weeks later, ending the war. The 1760 war was inconclusive. Although Burma had regained the upper Tenasserim coast to Tavoy, they still had to deal with Siamese supported rebellions in Lan Na and at Tavoy . The warfare resumed in August 1765, when two Burmese armies invaded again in a pincer movement on the Siamese capital. The Burmese armies took Ayutthaya in April 1767 after a 14-months' siege. The Burmese armies sacked the city and committed atrocities that mar the Burmese-Thai relations to the present. The Burmese were forced to withdraw a few months later due to the Chinese invasions of their homeland. Burma however had annexed the lower Tenasserim coast.
Output: What happened first: Burma was reunified or Burmese armies took Ayutthaya?
Inventors are always looking for ways to make our lives easier, greener and a whole lot more fun. Take a look at the following breakthroughs in science and technology. What in the world will inventors dream up next? Superhero Suit Have you ever dreamed of becoming a superhero? Dream no more. There's a real Iron Man suit, XOS 2, which instantly transforms the person wearing it. The suit provides the power to lift 200 pounds with ease and break slabs of wood with a single karate chop. It was designed to help the military with heavy lifting. One person in the suit could do the work of three soldiers. Up, Up and Away! It took him 30 years to develop it, and now Glen Martin's invention is ready to take off. The Martin Jetpack allows its operator to fly 8,000 feet into the air. Unfortunately, you can't soar through the skies too long. The jetpack holds only 30 minutes' worth of fuel. The aircraft will sell for $100,000. Hardworking Robot The EMIEW2 robot is the perfect office helper. Need a document delivered? No problem! It can also guide visitors to their destinations. The three-foot-tall robot can identify different human voices and respond to commands. One day, it may serve as a receptionist or a security guard. Green Machine Say goodbye to gasoline! The AirPod car runs on air power. That means this car won't pollute the environment. A high-pressure air tank can fill the car in minutes. The three-wheeler can travel about 130 miles between fill-ups. Beef Power All aboard the beef train! Amtrak's Heartland Flyer runs partly on fuel that is made from cow fat. The goal is to reduce carbon emissions by 10%. The train travels between Oklahoma City, Oklahoma, and Fort Worth, Texas. Robo-Guard EMILY is a robotic, four-foot-long buoy . She can swim through riptides at up to 24 miles per hour. Her inventor, Tony Mulligan, says that's 15 times as fast as human lifeguards! EMILY is powered by a tiny electric pump and operated by remote control.
Output: How many environment-friendly inventions are mentioned in the passage?
Different countries and cultures celebrate New Year in different ways. Many countries still follow the lunar calendar, meaning that their new year often starts in late January or in February. New Year celebrations for some countries (like China, Vietnam and Korea) last not one day, but up to two weeks! In the U.S., many people attend New Year parties. They drink champagne, dance, and cheer at the stroke of midnight. Fireworks, which in olden times scared away evil spirits, are very popular throughout the U. S. . U.S. residents often make one or more New Year's _ such as promising to quit smoking, lose weight, stop drinking. Most of these resolutions last little longer than a month. In the southern U.S. , many people eat black-eyed peas for good luck in the new year. In Mexico and Venezuela, many people wear red or yellow underwear for good luck. In Brazil, residents wear red white clothes for good luck, and in China, they wear red clothes and give children red envelops with money in them. In Iran, people wear brand new clothes on the first day of the new year. In Scotland, homeowners open the front door at midnight to let in the new year, and open the back door to let out the old year. In Switzerland, people kiss each other three times at midnight. In Spain, people eat 12 grapes-----one per chime----as the clock chimes midnight. In Japan, they ring a bell 108 times to get rid of the108 bad desires that people have. In Korea, they ring a bell 33 times in honor of 33 ancient soldiers.
Output: How do Americans celebrate their New Year?
Rising on the southern slopes of Maoke Mountains, the Digul flows first south and then west to empty into the Arafura Sea.
Output: What river does Digul connect to?
Today, there are many chances for those who wish to continue their education. However, nearly all require some break in one's career in order to attend school full time. Part-time education, that is, attending school at night or for one weekend a month, tends to drag the process out over time and puts the completion of a degree program out of reach of many people. Additionally, such programs require a fixed time commitment which can also impact negatively on one's career and family time. Of the many approaches to teaching and learning, however, perhaps the most flexible is that called distance learning. Distance learning is an educational method which allows the students the flexibility to study at his or her own pace to achieve the academic goals which are so necessary in today's world. The time required to study may be set aside at the student's convenience. Additionally, the student may enroll in distance learning courses from actually any place in the world, while continuing to pursue their chosen career. Individual assistance may be available via regular airmail, telephone, fax machine, teleconferencing and over the Internet. Good distance learning programs are characterized by the inclusion of a subject evaluation tool with every subject, so a student doesn't need to travel away from home to take a test. Another characteristic of a good distance learning program is the equivalence of the distance learning course with the same subject materials as those students taking the course on the home campus. The resultant diploma or degree should also be the same whether distance learning or on-campus study is employed. The individuality of the professor/student relationship is another characteristic of a good distance learning program. In the final analysis, a good distance learning program has a place not only for the individual student but also the company or business that wants to work in partnership with their employees for the educational benefit, professional development, and business growth of the organization. Supporting distance learning programs for their employees gives the business the advantage of retaining career-minded people while contributing to their personal and professional growth through education.
Output: What benefit will distance learning bring to an employee of a business?
Spanish men will have to learn to change diapers and do dishwashing under the terms of a new law designed to strike a blow. The law, due to be passed this month, is likely to cause a revolution in family affairs in a country where 40% of men reportedly don't do housework at all. It will oblige men to "share domestic responsibilities and the care and attention" of children and elderly family members, according to the draft approved by the Spanish parliament's justice commission. "This will be a good way of reminding people what their duties are. It is something feminists have been wanting for a long time," said Margarita Uria, of the Basque Nationalist Party, who was behind what is an amendment to a new divorce law. Failure to meet the obligations will be taken into consideration by judges when determining the terms of divorces. Men who refuse to do their part may be given less frequent contact with their children. Spanish women spend five times longer on housework than husbands. Even when both have jobs outside the home, Spanish women still do three times as much work in the house. "It is not just about housework, though," said Ms. Uria. A study five years ago by Spain's Center for Sociological Investigation concluded that fathers spent an average of 13 minutes each day looking after their children. Only 19 % of Spanish men thought it was right for mothers of school-age children to have a full-time job. More than a third thought mothers should not work outside the home at all. The Change to the Spanish legal code will see domestic obligations added to a list of marital duties that currently includes fidelity, living together and helping one another. That should guarantee that, when the law--which will also make divorce proceedings faster and easier--is voted on in parliament in the next few weeks, the obligation to share domestic chores will be added to the statute books.
Output: What is the percentage of Spanish men who don't do any housework?
The CDKL5 gene is located on the short (p) arm of the X chromosome at position 22.
Output: What chromosome is CDKL5?
Henry Keogh (born 1954) is an Australian convicted of murder.
Output: Which crime led to the conviction of Henry Keogh?
Natively disordered proteins are a growing class of anomalies to the structure-function paradigm. The natively disordered protein alpha-synuclein is the primary component of Lewy bodies, the cellular hallmark of Parkinson's disease. We noticed a dramatic difference in dilute solution 1H-15N Heteronuclear Single Quantum Coherence (HSQC) spectra of wild-type alpha-synuclein and two disease-related mutants (A30P and A53T), with spectra collected at 35 degrees C showing fewer cross-peaks than spectra acquired at 10 degrees C. Here, we show the change to be the result of a reversible conformational exchange linked to an increase in hydrodynamic radius and secondary structure as the temperature is raised. Combined with analytical ultracentrifugation data showing alpha-synuclein to be monomeric at both temperatures, we conclude that the poor quality of the 1H-15N HSQC spectra obtained at 35 degrees C is due to conformational fluctuations that occur on the proton chemical shift time scale. Using a truncated variant of alpha-synuclein, we show the conformational exchange occurs in the first 100 amino acids of the protein. Our data illustrate a key difference between globular and natively disordered proteins. The properties of globular proteins change little with solution conditions until they denature cooperatively, but the properties of natively disordered proteins can vary dramatically with solution conditions.
Output: Which is the primary protein component of Lewy bodies?
Patients with lung adenocarcinoma who carry epidermal growth factor receptor (EGFR) gene mutations respond remarkably well to EGFR tyrosine kinase inhibitor (EGFR-TKI), gefitinib, or erlotinib. However, the effect of EGFR-TKI treatment on the prolongation of overall survival (OS) of these patients remains uncertain, although several recent studies have shown prolongation of progression free survival compared with cytotoxic chemotherapy. A total of 304 patients with lung adenocarcinoma who had postoperative recurrent disease were studied. To eliminate potential biases as possible, the matching of four potential predictive factors of responsiveness to EGFR-TKI led to the identification of 81 pairs of patients (those who were treated with gefitinib and those who were not). A deletion mutation in exon 19 and a point mutation (L858R) in exon 21 of the EGFR gene were also analyzed. We compared the OS between the two groups. OS in the gefitinib group was significantly longer than in the control group (median, 63 vs. 41 months; p=0.015). EGFR mutations were detected in 65 out of 129 patients (50%) in the whole sample. EGFR mutational status was not an independent prognostic factor of gefitinib benefit; rather, it was a predictive factor. This study strongly suggested that gefitinib treatment improved OS of lung adenocarcinoma patients who had postoperative recurrence, especially those carrying EGFR mutations.
Output: Mutations in which gene determine response to both erlotinib and gefitinib?
Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P.05), and naproxen resulted in significant improvement of LBPI vs placebo (P.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.
Output: What is the target of tanezumab?
During brain development, excess neurons that are formed die by apoptosis. cln3 was recently identified as the gene defective in juvenile Batten disease, an inherited neurodegenerative disease of childhood. In this disease, neurons die by apoptosis. Overexpression of this gene increases survival of human NT2 neuronal precursor cells. We, therefore, hypothesized that cln3 may be present in developing neurons and may play an important role in regulating the developmental process. NT2 neuronal cells were induced to develop into mature neurons. We evaluated cln3 expression by reverse transcription PCR and immunohistochemistry over a 7-wk period of differentiation. Also, cln3 expression was characterized in neonatal rat brain during the first week of life (P-1, P0, P4, and P8) and at P30. cln3 was differentially expressed during neuronal development into nondividing post-mitotic neurons. The greatest expression was noted during wk 6 and then dropped to predifferentiation levels during wk 7. cln3 expression was detected in all the rat brain developmental stages evaluated. The greatest expression was seen at P0 and was double compared with the other stages. We conclude that cln3 is present during critical periods of neuronal cell differentiation and brain development. As cln3 is antiapoptotic, we hypothesize that cln3 plays an important role in regulating brain development. These findings may have implications for identifying strategies aimed at neuroprotection and neuronal survival during development.
Output: What is the effect of a defective CLN3 gene?
This was a 12-week randomized, placebo-controlled trial to assess the efficacy of quetiapine monotherapy in the treatment of posttraumatic stress disorder (PTSD). Eighty patients were randomly assigned to treatment with either quetiapine or placebo. The primary outcome measure was the Clinician-Administered PTSD Scale (CAPS). Secondary efficacy measures included the CAPS subscales, the Davidson Trauma Scale, the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impressions (CGI) scales for severity of Illness and improvement, the Hamilton Depression Rating Scale (HAM-D), and the Hamilton Anxiety Rating Scale (HAM-A). Safety measurements included adverse events, vital signs, the Abnormal Involuntary Movement Scale, the Barnes Akathisia Scale, the Simpson-Angus Scale, and the Arizona Sexual Experiences Scale. After a 1-week placebo run-in, quetiapine was started at a daily dosage of 25 mg and increased to a maximum of 800 mg; the average was 258 mg (range, 50-800 mg). Reductions in CAPS total, re-experiencing, and hyperarousal scores were significantly greater for the quetiapine group than for the placebo group. Greater improvements were also observed for quetiapine in scores on the Davidson Trauma Scale, CGI severity and improvement ratings, PANSS positive symptom and general psychopathology subscales, HAM-A, and HAM-D than for placebo. Adverse events were generally mild and expected based on prior studies of quetiapine in this and other patient population. There were no differences in safety measures between groups. Quetiapine monotherapy was efficacious in the treatment of PTSD. These findings suggest quetiapine as a single agent is effective in treating military PTSD.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
Chaperone-mediated autophagy is one of several lysosomal pathways of proteolysis. This pathway is activated by physiological stresses such as prolonged starvation. Cytosolic proteins with particular peptide sequence motifs are recognized by a complex of molecular chaperones and delivered to lysosomes. No vesicular traffic is required for this protein degradation pathway, so it differs from microautophagy and macroautophagy. Protein substrates bind to a receptor in the lysosomal membrane, the lysosome-associated membrane protein (lamp) type 2a. Levels of lamp2a in the lysosomal membrane are controlled by alterations in the lamp2a half-life as well as by the dynamic distribution of the protein between the lysosomal membrane and the lumen. Substrate proteins are unfolded before transport into the lysosome lumen, and the transport of substrate proteins requires a molecular chaperone within the lysosomal lumen. The exact roles of this lysosomal chaperone remain to be defined. The mechanisms of chaperone-mediated autophagy are similar to mechanisms of protein import into mitochondria, chloroplasts, and the endoplasmic reticulum.
Output: Which is the receptor for substrates of Chaperone Mediated Autophagy?
Elizabeth Bishop, who was famous for the poetry A Prodigal, Filling Station , Sandpiper, Manuelzinho and so on, was an influential American poet of the 20th century. Her poetry often shows things that concerned her throughout her life, such as her search for a sense of home. Her troubled childhood and feelings of loneliness from this time affected her character and poetry. Bishop's painful childhood is apparent in some of her poems. Her father died when she was eight months old and her mother was mad when she was five. Bishop was raised firstly by her mother's parents and then by her father's parents. This experience left her confused about belonging. She had no home and this was shown in her poetry. In "A Prodigal", when the character in the poem makes up his mind to go home, there is a sense of pessimism for Bishop who has no home. The lack of a sense of home has contributed to her depression all her life. Bishop attempts to make small, everyday experiences extraordinary in her poems such as "Filling Station" .In "Filling Station ", Bishop describes the beautyof a family filling station. Although it is "dirty" there is order in it. Simple family life is celebrated in it. She recognizes the value of home and beauty in everyday life, but she is only an observer of these. Distance remains between her and the family at the filling station. Bishop's struggle to locate herself in the world is seen no more clearly than in "sandpiper". It deals with searching for something in a confusing world. She uses the metaphor of the bird which is "looking for something". The "something" isn't specific . It seems as if the bird doesn't know what he wants; the only certain thing is that he is searching. Bishop's poems are personal on a more subtle level, especially when her childhood, travels, etc, are taken into consideration. It is believed that Bishop is a complex poet who uses her poetry to find this feeling of belonging.
Output: Which of Bishop's poems shows her love for simple family life?
LHCII, the most abundant membrane protein on earth, is the major light-harvesting complex of plants. It is generally accepted that LHCII is associated with Photosystem II and only as a short-term response to overexcitation of PSII a subset moves to Photosystem I, triggered by its phosphorylation (state1 to state2 transition). However, here we show that in most natural light conditions LHCII serves as an antenna of both Photosystem I and Photosystem II and it is quantitatively demonstrated that this is required to achieve excitation balance between the two photosystems. This allows for acclimation to different light intensities simply by regulating the expression of LHCII genes only. It is demonstrated that indeed the amount of LHCII that is bound to both photosystems decreases when growth light intensity increases and vice versa. Finally, time-resolved fluorescence measurements on the photosynthetic thylakoid membranes show that LHCII is even a more efficient light harvester when associated with Photosystem I than with Photosystem II.
Output: Which is the most abundant membrane protein on Earth?
Kirsteen O'Sullivan (born 24 November 1979) is a Scottish presenter on TV3 in Ireland.
Output: What is Kirsteen O'Sullivan's place of employment?
This Is Not a Film (Persian: In film nist - ) is an Iranian documentary film by Jafar Panahi and Mojtaba Mirtahmasb.
Output: Who was This Is Not a Film directed by?
The two major virulence factors of Bacillus anthracis are the tripartite toxin and the polyglutamate capsule, which are encoded by genes on the large plasmids, pXO1 and pXO2, respectively. The genes atxA, located on pXO1, and acpA, located on pXO2, encode positive trans-acting proteins that are involved in bicarbonate-mediated regulation of toxin and capsule production, respectively. A derivative strain cured of pXO1 produced less capsular substance than the parent strain harbouring both pXO1 and pXO2, and electroporation of the strain cured of pXO1 with a plasmid containing the cloned atxA gene resulted in an increased level of capsule production. An acpA-null mutant was complemented by not only acpA but also the atxA gene. The cap region, which is essential for encapsulation, contains three genes capB, capC, and capA, arranged in that order. The atxA gene stimulated capsule synthesis from the cloned cap region. Transcriptional analysis of cap by RNA slot-blot hybridization and primer-extension analysis revealed that atxA activated expression of cap in trans at the transcriptional level. These results indicate that cross-talk occurs, in which the pXO1-located gene, atxA, activates transcription of the cap region genes located on pXO2. We identified two major apparent transcriptional start sites, designated P1 and P2, located at positions 731 bp and 625 bp, respectively, upstream of the translation-initiation codon of capB. Transcription initiated from P1 and P2 was activated by both atxA and acpA, and activation appeared to be stimulated by bicarbonate. Deletion analysis of the upstream region of the cap promoter revealed that activation by both atxA and acpA required a DNA segment of 70 bp extending upstream of the P1 site. These results suggest that cross-talk by atxA to the genes encoding capsule synthesis is caused by the interaction of the atxA gene product with a regulatory sequence upstream of cap.
Output: Which metabolite activates AtxA?
There are many kinds of sales. For example, a "back-to-school sale" is held near the beginning of the school year. Parents like the lower prices of the clothes and school supplies for their children. A "midnight madness" event starts very late at night. An "early bird special" sale starts very early in the morning. This kind of sale is popular the day after Thanksgiving in November. A favorite sale among many people is the "buy one, get one free" sale. You buy one thing and get a second one without cost. When people see the word "free" in an advertisement they know they are getting a good deal. As a matter of fact, it is not the case. Another kind of sale is a "going out of business" sale. This is when a storeowner tries to sell all the goods in the store before closing the business permanently . Let us say the store sells floor coverings. The owner lowers the prices and puts up a sign that says: "Going out of business sale. All items MUST be sold by tomorrow." People who buy the floor coverings think they are getting a special deal because everything must be sold in a short period of time. Then, days later they see the store did not close permanently. And they see the same sign that claims the store is going out of business. Some business owners really do not end the business. They just want to earn more money. People also hold their own sales. They hold garage sales and yard sales outside their home. They sell things they no longer want. Groups such as religious centers or schools hold bake sales. They sell cakes, cookies and other baked goods to raise money. In America, you can always find a good sale, no matter the day or time of year. There is the Independence Day sale, Veteran's Day sale, clearance sale, sidewalk sale, red tag sale, white sale, blue light special, liquidation sale, half-off sale, warehouse sale, tent sale ...
Output: What do we call the sale if it starts before the sun rises?
Zillah Smith Gill (29 May 1859--17 August 1937) was a New Zealand local politician and community leader.
Output: What country was Zillah Smith Gill from?
I decided to go back to school in the fall of 2008 after not being happy with my current job and financial status. I obtained my Associate's Degree in May 2002 in Commercial Arts. After graduation, I had trouble obtaining a job in that field. For years, I was going from one job to another feeling unfilled, and I was not satisfied with the instability. I decided to go back to school for either International Business or Psychology. I weighed the pros and cons of both professions and Psychology won. I like helping my friends and family, when they go through hard situations in their life by giving them sound advice and being honest with them. Also, I was interested in "the mind". I was searching for online schools because my work schedule at my current job would not allow me to attend a regular class. I was nervous about starting online classes because I heard mixed stories from other friends who were taking online classes. I decided to do it anyway to experience something different. I wanted to find an online school that was affordable and reputable. Through my search, I discovered Walden University, which is specially for working adults who want to obtain a bachelor's degree or higher. The process of getting accepted was easy, which included writing an essay on why I wanted to attend their school, transferring my previous credits, etc. I am currently enrolled in the Bachelors program for psychology, and I am paying for college via financial-aid loans and grants. This experience has been interesting yet trying as sometimes it was difficult to balance work, school and home life. I learned a lot about psychology and myself. For example, I like writing about current events, relationships and traveling. I thought my English composition was ordinary, but after taking a few classes at Walden University, I improved my English composition and it made me feel confident enough to start writing professionally so I became a freelance writer. Currently, I am only three classes away from obtaining my Bachelor's Degree in Psychology! It was one of the best decisions I made in my life.
Output: What did the author study originally when he was in college?
A family in Guelph, Ontario is spending a year living "in 1982".They're doing it so their kids can see what life was like before technology like iPads, computers and even coffee machines was part of everyday life. They have stopped using all technology from their home and are relying on the things people would have used back in the 80s.There is a box at the front door where people can put their cell phones in, while they're visiting the family. Blair McMillan and his wife Morgan want their kids--Trey, 5, and Denton, 2 -- to have a year without technology. Instead of reading ereaders, they are reading books. Instead of using a GPS, they used paper maps. The home the family is living in was built in the 1980s.Even the way they dress and style their hair is from the 80s. The whole idea started when young Trey was called to come outside. He didn't because he was busy playing on the iPad. That's why his dad thought of the idea of living "in 1982" for a year. The family plans to live like "it's 1982" until April next year. To them, one of the hardest things was giving up their cell phones.
Output: Who made the family have the idea of living "in 1982"?
Untreated sleep disorders may contribute to secondary causes of uncontrolled hypertension, cardiovascular disease (CVD), and stroke. Restless legs syndrome, or Willis-Ekbom Disease (RLS/WED), is a common sensorimotor disorder with a circadian rhythmicity defined by an uncontrollable urge to move the legs that worsens during periods of inactivity or at rest in the evening, often resulting in sleep disruptions. Sleep disorders such as insomnia and obstructive sleep apnea (OSA) are established risk factors for increased risk of hypertension and vascular diseases. This literature review outlines the lessons learned from studies demonstrating insomnia and OSA as risk factors for hypertension and vascular diseases to support the epidemiologic and physiologic evidence suggesting a similar increase in hypertension and vascular disease risk due to RLS. Understanding the relationships between RLS and hypertension, CVD, and stroke has important implications for reducing the risks associated with these diseases.
Output: Willis-Ekbom disease is also known as?
Shi Qian is a fictional character in Water Margin, one of the Four Great Classical Novels of Chinese literature.
Output: To which fictional work does Shi Qian belong in?
Arise, My Love won the Academy Award for Best Story (Benjamin Glazer and Hans Szekely), and was nominated for Best Music (Victor Young), Best Cinematography (Charles Lang) and Best Art Direction (Hans Dreier and Robert Usher).
Output: What award was Arise, My Love nominated for?
When is a person considered an adult? That depends. Most teens become physically mature by the age of 16 or so. But they are not adults in a legal sense until they are older. For example, in the U.S., you must be 18 to vote. Once adulthood begins, it can be divided into three stages: (1) early, (2) middle, and (3) late adulthood. Early adulthood starts at age 18 or 21. It continues until the mid-30s. During early adulthood, people are at their physical peak. They are also usually in good health. The ability to have children is greatest during early adulthood, as well. This is the stage of life when most people complete their education. They are likely to begin a career or take a full-time job. Many people also marry and start a family during early adulthood. Middle adulthood begins in the mid-30s. It continues until the mid-60s. During middle adulthood, people start to show signs of aging. Their hair slowly turns gray. Their skin develops wrinkles. The risk of health problems also increases during middle adulthood. For example, heart disease, cancer, and diabetes become more common during this time. This is the stage of life when people are most likely to achieve career goals. Their children also grow up and may leave home during this stage. Late adulthood begins in the mid-60s. It continues until death. This is the stage of life when most people retire from work. They are also likely to reflect on their life. They may focus on their grandchildren. During late adulthood, people are not as physically able. For example, they usually have less muscle and slower reflexes. Their immune system also doesnt work as well as it used to. As a result, they have a harder time fighting diseases like the flu. The risk of developing diseases such as heart disease and cancer continues to rise. Arthritis is also common. In arthritis, joints wear out and become stiff and painful. As many as one in four late adults may develop Alzheimers disease. In this disease, brain changes cause mental abilities to decrease. This family picture shows females in each of the three stages of life. Which stage does each represent? Despite problems such as these, many people remain healthy and active into their 80s or even 90s. Do you want to be one of them? Then adopt a healthy lifestyle now and follow it for life. Doing so will increase your chances of staying healthy and active to an old age. Exercising the body and brain help prevent the physical and mental effects of aging.
Output: during this time, brain changes cause mental abilities to decrease.
Young Komodo dragons are vulnerable and therefore dwell in trees, safe from predators and cannibalistic adults.
Output: How endangered does the iucn consider Komodo dragon?
Nguyen Van Bay (Born in Lai Vung, 1936) was a jet fighter ace for the Vietnam People's Air Force (North Vietnamese Air Force) during the Vietnam War.
Output: What was the war that Nguyễn Văn Bảy fought in?
Miller Worsley (8 July 1791 -- 2 May 1835) was an officer in the Royal Navy, best known for playing a major part in the Engagements on Lake Huron in the Anglo-American War of 1812.
Output: In what military branch did Miller Worsley serve?
To Live and Die in Tsimshatsui is a 1994 Hong Kong crime film directed by Andrew Lau and starring Jacky Cheung, Tony Leung, Jacklyn Wu and Power Chan.
Output: Which place is To Live and Die in Tsimshatsui in?
Rudolphe Cabanel (also Rudolph) (1763--1839) was a German architect, engineer and machinist, known for his work on British theatres.
Output: The date of birth for Rudolphe Cabanel is what?
Bone destruction is a prominent feature of multiple myeloma, but conflicting data exist on the expression and pathophysiologic involvement of the bone remodeling ligand RANKL in this disease and the potential therapeutic benefits of its targeted inhibition. Here, we show that RANKL is expressed by primary multiple myeloma and chronic lymphocytic leukemia (CLL) cells, whereas release of soluble RANKL was observed exclusively with multiple myeloma cells and was strongly influenced by posttranscriptional/posttranslational regulation. Signaling via RANKL into multiple myeloma and CLL cells induced release of cytokines involved in disease pathophysiology. Both the effects of RANKL on osteoclastogenesis and cytokine production by malignant cells could be blocked by disruption of RANK-RANKL interaction with denosumab. As we aimed to combine neutralization of RANKL with induction of antibody-dependent cellular cytotoxicity of natural killer (NK) cells against RANKL-expressing malignant cells and as denosumab does not stimulate NK reactivity, we generated RANK-Fc fusion proteins with modified Fc moieties. The latter displayed similar capacity compared with denosumab to neutralize the effects of RANKL on osteoclastogenesis in vitro, but also potently stimulated NK cell reactivity against primary RANKL-expressing malignant B cells, which was dependent on their engineered affinity to CD16. Our findings introduce Fc-optimized RANK-Ig fusion proteins as attractive tools to neutralize the detrimental function of RANKL while at the same time potently stimulating NK cell antitumor immunity.
Output: To the ligand of which receptors does Denosumab (Prolia) bind?
Edward Julius Detmold (21 November 1883 Putney, Wandsworth, Surrey - 1 July 1957 Montgomery) and his twin brother Charles Maurice Detmold (1883-1908) were prolific Victorian book illustrators.
Output: What is Edward Julius Detmold's brothers name?
The Covered Wagon is a 1923 American silent Western film released by Paramount Pictures.
Output: Which production company is involved with The Covered Wagon?
John Henry Michell, FRS(26 October 1863 -- 3 February 1940) was an Australian mathematician, Professor of Mathematics at the University of Melbourne.
Output: What university did John Henry Michell attend?
Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensory-motor neurological disorder with a circadian component. RLS is characterized by uncomfortable sensations in the extremities, generally at night or during sleep, which often leads to an uncontrollable urge to move them for relief. Recently, genomic studies identified single-nucleotide polymorphisms in BTBD9, along with three other genes, as being associated with a higher risk of RLS. Little is known about the function of BTBD9 or its potential role in the pathophysiology of RLS. We therefore examined a line of Btbd9 mutant mice we recently generated for phenotypes similar to symptoms found in RLS patients. We observed that the Btbd9 mutant mice had motor restlessness, sensory alterations likely limited to the rest phase, and decreased sleep and increased wake times during the rest phase. Additionally, the Btbd9 mutant mice had altered serum iron levels and monoamine neurotransmitter systems. Furthermore, the sensory alterations in the Btbd9 mutant mice were relieved using ropinirole, a dopaminergic agonist widely used for RLS treatment. These results, taken together, suggest that the Btbd9 mutant mice model several characteristics similar to RLS and would therefore be the first genotypic mouse model of RLS. Furthermore, our data provide further evidence that BTBD9 is involved in RLS, and future studies of the Btbd9 mutant mice will help shine light on its role in the pathophysiology of RLS. Finally, our data argue for the utility of Btbd9 mutant mice to discover and screen novel therapeutics for RLS.
Output: Willis-Ekbom disease is also known as?
Epidemiology of Clostridium difficile is characterized by worldwide increase of C. difficile infections (CDI) and the emergence of new epidemic outbreak strains with the capacity for global spreading. Long-term local surveillance at the University of Saarland Medical Center between 2000 and 2013 shows that the incidence rate of laboratory-confirmed CDI was influenced by local epidemiology as well as by testing strategies. Since 2008, molecular typing of C. difficile was regularly performed for symptomatic hospitalized patients by surface-layer protein A sequence typing (slpAST), which is an established highly standardized technique for genotyping of C. difficile. The results were assigned to known ribotypes for better comparison to international data. It could be demonstrated that distribution of genotypes was different between age groups. Older patients were predominantly infected with ribotype 001 and 027, whereas ribotype 027 was not detected in the pediatric population. Molecular typing of German isolates sent to the advisory laboratory between 2011 and 2013 revealed that ribotype 027 is present with high percentages in most German regions except for the very North. In conclusion, optimized testing of all hospitalized patients with diarrhea should be generally implemented to avoid under-diagnosis of C. difficile infection. Ribotype 027 is highly prevalent in Germany, but its infections are restricted to older patients, while absent in children. Molecular typing of suspected hospital outbreaks and of patients with severe or recurrent disease may help to better understand virulence and epidemic spreading of C. difficile.
Output: Which main ribotype of Clostridium difficile is responsible of the recent outbreak?
The River Lagan (from Irish Abhainn an Lagain, meaning ''river of the low-lying district''; Ulster Scots: Lagan Watter) is a major river in Northern Ireland which runs 53.5 miles (86 km) from the Slieve Croob mountain in County Down to Belfast where it enters Belfast Lough, an inlet of the Irish Sea.
Output: Which river system contains River Lagan?
New treatment options are urgently needed for patients with relapsed chronic lymphocytic leukemia (CLL) who fail to respond to currently available therapies or cannot achieve a sustained response. Moreover, targeted agents with less myelotoxicity are necessary to treat patients with multiple comorbidities who would otherwise be unable to tolerate standard regimens. Ibrutinib, a Bruton's tyrosine kinase inhibitor, has shown highly encouraging results in phase I/II trials in patients with treatment-naive, relapsed and refractory CLL even in the presence of high risk disease or poor prognostic markers. In phase I/II trials, ibrutinib 420 mg or 840 mg - given continuously as single agent or at a dose of 420 mg daily in combination with a monoclonal antibody or chemoimmunotherapy - has been associated with high response rates and durable clinical remissions. Phase II and III trials are currently under way for treatment-naive patients, relapsed/refractory patients, and for those patients harboring a 17p deletion.
Output: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?
(S)-(-)-3-(3-(methylsulfonyl)phenyl)-1-propylpiperidine ((-)-OSU6162) is a phenylpiperidine derivative which exhibits low affinity to the dopamine D2 receptor in vitro. However, in vivo, positron emission tomography scanning studies show that the compound displaces the selective dopamine D2 receptor antagonist, raclopride. We have evaluated, in this study, the effect of (-)-OSU6162, on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias in a primate model of Parkinson's disease. Five 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated cynomolgus monkeys with a stable parkinsonian syndrome and reproducible dyskinesias to L-DOPA were used in this study. The monkeys were housed in observation cages equipped with an electronic motility monitoring system. They were injected subcutaneously (s.c.) with L-DOPA methyl ester (125 mg per animal) plus benserazide (50 mg per animal; L-DOPA/benserazide) alone or in combination with (-)-OSU6162 (1.0, 3.0, 6.0 or 10 mg/kg, s.c.). Subcutaneous injection of sterile saline was used as control. L-DOPA/benserazide increased locomotion and improved parkinsonism but also induced dyskinesias. Co-administration of (-)-OSU6162 with L-DOPA/benserazide produced a significant reduction in L-DOPA-induced dyskinesias. This improvement in L-DOPA-induced dyskinesias occurred mainly at the onset of the L-DOPA/benserazide effect as reflected by an increase in the duration of the "ON" state without dyskinesias up to 3.4 fold after (-)-OSU6162 co-administration as compared to L-DOPA/benserazide alone. The anti-dyskinetic effect of (-)-OSU6162 was maintained during 14 days and no tolerance to this effect was observed. Our data suggests that (-)-OSU6162 could be of significant clinical value to reduce L-DOPA-induced dyskinesias in fluctuating advanced Parkinson's disease patients.
Output: Which drug is benserazide usually co-administered with?
The Boys in Blue is a 1982 British comedy film directed by Val Guest and starring Tommy Cannon, Bobby Ball, Suzanne Danielle and Roy Kinnear.
Output: Which director worked on The Boys in Blue?