niryuu/sni-each-converted huggingface dataset:
The two main sodium-glucose cotransporters (SGLTs), SGLT1 and SGLT2, provide new therapeutic targets to reduce hyperglycaemia in patients with diabetes. SGLT1 enables the small intestine to absorb glucose and contributes to the reabsorption of glucose filtered by the kidney. SGLT2 is responsible for reabsorption of most of the glucose filtered by the kidney. Inhibitors with varying specificities for these transporters (eg, dapagliflozin, canagliflozin, and empagliflozin) can slow the rate of intestinal glucose absorption and increase the renal elimination of glucose into the urine. Results of randomised clinical trials have shown the blood glucose-lowering efficacy of SGLT inhibitors in type 2 diabetes when administered as monotherapy or in addition to other glucose-lowering therapies including insulin. Increased renal glucose elimination also assists weight loss and could help to reduce blood pressure. Effective SGLT2 inhibition needs adequate glomerular filtration and might increase risk of urinary tract and genital infection, and excessive inhibition of SGLT1 can cause gastro-intestinal symptoms. However, the insulin-independent mechanism of action of SGLT inhibitors seems to offer durable glucose-lowering efficacy with low risk of clinically significant hypoglycaemia at any stage in the natural history of type 2 diabetes. SGLT inhibition might also be considered in conjunction with insulin therapy in type 1 diabetes.
Output: Which protein does empagliflozin inhibit?
RNA component of mitochondrial RNA processing endoribonuclease, also known as RMRP, is a human gene.
Output: What species is RMRP specific to?
Sweet Sinner is a Canadian pornographic film studio, founded by pornographic actress and director Nica Noelle in 2009.
Output: When was the inception of Sweet Sinner?
The effects of SEA0400, a selective inhibitor of the Na(+)/Ca(2+) exchanger (NCX), on Na(+)-dependent Ca(2+) uptake and catecholamine (CA) release were examined in bovine adrenal chromaffin cells that were loaded with Na(+) by treatment with ouabain and veratridine. SEA0400 inhibited Na(+)-dependent (45)Ca(2+) uptake and CA release, with the IC(50) values of 40 and 100 nM, respectively. The IC(50) values of another NCX inhibitor KB-R7943 were 1.8 and 3.7 microM, respectively. These results indicate that SEA0400 is about 40 times more potent than KB-R7943 in inhibiting NCX working in the reverse mode. In intact cells, SEA0400 and KB-R7943 inhibited CA release induced by acetylcholine and DMPP. The IC(50) values of SEA0400 were 5.1 and 4.5 microM and the values of KB-R7943 were 2.6 and 2.1 microM against the release induced by acetylcholine and DMPP, respectively, indicating that the potency of SEA0400 is about a half of that of KB-R7943 in inhibiting the nicotinic receptor-mediated CA release. The binding of [(3)H]nicotine with nicotinic receptors was inhibited by SEA0400 (IC(50) = 90 microM) and KB-R7943 (IC(50) = 12 microM). From these results, it is concluded that unlike KB-R7943, SEA0400 has a potent and selective action on NCX in bovine adrenal chromaffin cells.
Output: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
Heroes of Gaia (Chinese: ; pinyin: Yingxiong Zhi Cheng), known in the separate European version as Castle of Heroes, is a massively multiplayer online fantasy browser-based strategy game developed by the Chinese developer Snail Games and published in the United States by its U.S. publishing division, Snail Games USA.
Output: Who worked on Heroes of Gaia?
In the United States Federal Budget for 2010, entitled 'A New Era of Responsibility', the DHS was allocated a discretionary budget of $42.7 billion . The end-of-yearDHS Annual Financial Report for financial year 2010 showed a net cost of operations of $56.4 billion , out of total budgetary resources of $83.2 billion . The components with the highest net cost were US Coast Guard , U.S. Customs and Border Protection , and Federal Emergency Management Agency . Revenues of $10.4 billion were generated in the year . According to the Washington Post, "DHS has given $31 billion in grants since 2003 to state and local governments for homeland security and to improve their ability to find and protect against terrorists, including $3.8 billion in 2010."
Output: Which was higher the DHS net coast of operations or their total budgetary resources?
Gardiners Creek, originally known as Kooyongkoot Creek, is a waterway in the eastern suburbs of Melbourne, and part of the Yarra River catchment.
Output: What river is Gardiners Creek a tributary of?
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an autosomal dominant heart muscle disorder that causes arrhythmia, heart failure, and sudden death. Previously we mapped the genetic locus for the triad of autosomal recessive ARVC, palmoplantar keratoderma, and woolly hair (Naxos disease) to chromosome 17q21, in which the gene for plakoglobin is encoded. This protein is a key component of desmosomes and adherens junctions, and is important for the tight adhesion of many cell types, including those in the heart and skin. We studied 19 individuals with Naxos disease, as well as unaffected family members and unrelated individuals from the neighbouring Greek islands of Naxos and Milos. Gene sequence was determined by reverse transcriptase PCR from RNA isolated from the skin of an affected individual and mutations in other cases were confirmed by restriction-enzyme analysis. A homozygous 2 base pair deletion in the plakoglobin gene was identified only in the 19 affected individuals. This deletion caused a frameshift and premature termination of the protein, which was shown by western blot analysis. 29 clinically unaffected family members were heterozygous for the mutation; 20 unrelated individuals from Naxos and 43 autosomal dominant ARVC probands were homozygous for the normal allele. The finding of a deletion in plakoglobin in ARVC suggests that the proteins involved in cell-cell adhesion play an important part in maintaining myocyte integrity, and when junctions are disrupted, cell death, and fibrofatty replacement occur. Therefore, the discovery of a mutation in a protein with functions in maintaining cell junction integrity has important implications for other dominant forms of ARVC, related cardiomyopathies, and other cutaneous diseases.
Output: Which gene is mutated in a subtype of arrhythmogenic right ventricular cardiomyopathy known as Naxos disease?
Fossils are the preserved remains of animals, plants, and other organisms from the distant past. Examples of fossils include bones, teeth, and impressions. By studying fossils, evidence for evolution is revealed. Paleontologists are scientists who study fossils to learn about life in the past. Fossils allow these scientists to determine the features of extinct species. Paleontologists compare the features of species from different periods in history. With this information, they try to understand how species have evolved over millions of years ( Figure below). Until recently, fossils were the main source of evidence for evolution ( Figure below). Through studying fossils, we now know that todays organisms look much different in many cases than those that were alive in the past. Scientists have also shown that organisms were spread out differently across the planet. Earthquakes, volcanoes, shifting seas, and other movements of the continents have all affected where organisms live and how they adapted to their changing environments. There are many layers of rock in the Earths surface. Newer layers form on top of the older layers; the deepest rock layers are the oldest. Therefore, you can tell how old a fossil is by observing in which layer of rock it was found. Evolution of the horse. Fossil evi- dence, depicted by the skeletal frag- ments, demonstrates evolutionary mile- stones in this process. Notice the 57 million year evolution of the horse leg bones and teeth. Especially obvious is the transformation of the leg bones from having four distinct digits to that of todays horse. The fossils and the order in which fossils appear is called the fossil record. The fossil record provides evidence for when organisms lived on Earth, how species evolved, and how some species have gone extinct. Geologists use a method called radiometric dating to determine the exact age of rocks and fossils in each layer of rock. This technique, which is possible because radioactive materials decay at a known rate, measures how much of the radioactive materials in each rock layer have broken down ( Figure 1.3). Radiometric dating has been used to determine that the oldest known rocks on Earth are between 4 and 5 billion years old. The oldest fossils are between 3 and 4 billion years old. Remember that during Darwins time, people believed the Earth was just about 6,000 years old. The fossil record proves that Earth is much older than people once thought.
Output: the oldest fossils on earth are
To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.
Output: What is the target of tanezumab?
Vaginal microbicides for the prevention of HIV transmission may be an important option for protecting women from infection. Incorporation of dapivirine, a lead candidate nonnucleoside reverse transcriptase inhibitor, into intravaginal rings (IVRs) for sustained mucosal delivery may increase microbicide product adherence and efficacy compared with conventional vaginal formulations. Twenty-four healthy HIV-negative women 18-35 years of age were randomly assigned (1:1:1) to dapivirine matrix IVR, dapivirine reservoir IVR, or placebo IVR. Dapivirine concentrations were measured in plasma and vaginal fluid samples collected at sequential time points over the 33-day study period (28 days of IVR use, 5 days of follow-up). Safety was assessed by pelvic/colposcopic examinations, clinical laboratory tests, and adverse events. Both IVR types were safe and well tolerated with similar adverse events observed in the placebo and dapivirine groups. Dapivirine from both IVR types was successfully distributed throughout the lower genital tract at concentrations over 4 logs greater than the EC50 against wild-type HIV-1 (LAI) in MT4 cells. Maximum concentration (Cmax) and area under the concentration-time curve (AUC) values were significantly higher with the matrix than reservoir IVR. Mean plasma concentrations of dapivirine were <2 ng/mL. These findings suggest that IVR delivery of microbicides is a viable option meriting further study.
Output: Which infection can be prevented with Dapivirine?
Turner's syndrome is defined as a congenital disease determining by quantitative and/or structural aberrations of one from two X chromosomes with frequent presence of mosaicism. Clinically it is characterized by growth and body proportion abnormalities, gonadal dysgenesis resulting in sexual infantilism, primary amenorrhoea, infertility, characteristic stigmata, anomalies of heart, renal and bones and the presence of some diseases like Hashimoto thyroiditis with hypothyroidism, diabetes mellitus type 2, osteoporosis, hypertension. Turner's syndrome occurs in 1:2000 to 1:2500 female livebirth. The most frequent X chromosome aberrations in patients with phenotype of Turner syndrome are as follows: X monosomy - 45,X; mosaicism (50-75%), including 45,X/46,XX (10-15%), 45,X/46,XY (2-6%), 45,X/46,X,i(Xq), 45,X/46,X,del(Xp), 45,X/46,XX/47,XXX; aberration of X structure: total or partial deletion of short arm of X chromosome (46,X,del(Xp)) isochromosom of long arm of X chromosome (46,X,(i(Xq)), ring chromosome (46, X,r(X)), marker chromosome (46,X+m). Searching of X chromosome and mapping and sequencing of genes located at this chromosome (such as SHOX, ODG2, VSPA, SOX 3) have made possible to look for linkage between phenotypes and adequate genes or regions of X chromosome. In this paper current data concerning correlation between phenotype and karyotype in patients with TS have been presented.
Output: What chromosome is affected in Turner's syndrome?
IT'S over - millions of Senior 3 students across the country have finished their last exams. But in two years, it'll be your turn in the examination room. How can you spend the time you have left to best effect? Read these thoughts from new graduates to get some pointers. Cao A'min, 18 Xuanhua No 1 High School, Hebei Study: Keeping pace with teachers is a good way to study. Teachers are experienced and their plans are systematic . But remember to work in a way that suits you. It's also important to learn from past mistakes. Keep a notebook to make a record of the mistakes you make - it'll help you avoid making the same ones later. Zhang Zilu, 17 Xinyu No 1 High School, Jiangxi Friendship: This time of life may be hard, but you're not alone. You may be busy studying, but you can show you care by calling your friends or sending a short message. Don't let your friendships die. Some boys and girls in my class were in love, but I'd advise against a relationship at this stage. Zhan Yu, 17 Huanggang High School, Hubei Health: It's as important to live well as it is to study well, I think. I went to bed no later than 11:30 pm. It put me in the right mood for the next day. I didn't follow a special diet , but I did make sure I ate a nutritious breakfast each day. Ju Shuntian, 18 Yantai Economic and Technological Development Zone Senior High School, Shandong Relaxation: The person who plays well, studies well. Having a lot of schoolwork doesn't mean having to give up on every other activity. I played basketball or took a walk to relax when I felt tired. Time out is not a waste of time but helps you study more efficiently . Zhang Qingzhou, 17 Dongtai High School, Jiangsu Options: Besides taking the big exam, you have other choices for college. I took the independent enrollment exam held by Peking University and some other students even prepared to study abroad. Pay attention to any relevant information you can find, whether it's from school, the news media or another source .
Output: If you'd like to take the independent enrollment, what should you do?
The King Willem-Alexander Canal (Dutch: Koning Willem-Alexanderkanaal), named after King Willem-Alexander of the Netherlands, is a 6 km long canal in the northeastern Netherlands.
Output: Who is the King Willem-Alexander Canal named after?
The Most Scenic Drives in America Price: $25.00 Description: This book includes 120 easytofollow maps, 400 breathtaking photos, fascinating facts, tips, suggested side trips and much more. What Works What Doesn't: The Bottom Line on Everything Health Price:$31.96 Description: Now, with What Works What Doesn't, you can stop wasting time and money on products, treatments and approaches that don't work, and start getting real results from strategies that do. Strange Stories, Amazing Facts of America's Past Price: $34.96 Description: If you ever thought history was dull and our forefathers stodgy, here is a book to change your mind.This is America at its most fascinating--more than 600 true stories as gripping as a whodunit, as fast paced as a spy chase, as atmospheric as a historical novel--guaranteed to give many hours of reading pleasure. How To Write Your Life Story Price: $26.95 Description: Discover how easy it is to write your own life story! This fascinating and practical guide leads you through the process of creating your own personal memoir. Plus, find out how to use photos and other mementos to add even more meaning to your story. Disease Free Price: $31.96 Description:Stop Disease Before it Starts. Doctors estimate that at least 60% of chronic disease cases could be avoided entirely, and Disease Free shows you how. Detailed prevention plans for more than 90 conditions help you sidestep everything from heartburn to high blood pressure, colds to cancer. Complete Guitar Course Price:$30.00 Description: Learn to play in 20 easytofollow lessons! This deluxe handbook is packed with everything you need to learn from choosing the right guitar for you, to basic fingering, chords, and techniques. Handsomely designed in full color1 and jammed with practical tips, this comprehensive course will have you making beautiful music in no time at all! Care Free Plants Price:$34.96 Description: This book reveals the secret to great gardening: working smarter, not harder. Discover how you can spend less effort, save money, and still end up with more time to enjoy your beautiful garden. With this book in hand, the dream is within easy reach.
Output: Which book of the above can she buy for Marry's older mother?
Nestin is an intermediate filament protein expressed in neuroepithelial stem cells during development and it is later replaced by cell specific neuronal or glial filaments. Nevertheless, nestin cells remain within adult tissues and they can be regarded as potential neural stem cell (NSC). Nestin cells have been detected in Schwann cells related with sensory corpuscles of rodent and they have been demonstrated to be NSC. We have investigated the existence of nestin in human cutaneous cells Meissner and Pacinian corpuscles through the use of immunohistochemistry techniques and in situ hybridization. S100 protein (also regarded as a marker for NSC) and vimentin (the intermediate filament of mature Schwann cells in sensory corpuscles) were also investigated. The results show that the adult human cutaneous sensory Meissner and Pacinian corpuscles contains a small population of Schwann-related cells (vimentin) which on the basis of their basic immunohistochemical characteristics (S100 protein, nestin) can be potential NSCs. Cells sharing identical immunohistochemical profile were also found in the close vicinity of Meissner corpuscles. Because their localization they are easily accessible and may represent a peripheral niche of NSC to be used for therapeutic goals.
Output: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
Chronic myeloid leukemia (CML) is arguably the best understood of all human malignancies. Its origins in the hematopoietic stem cell can be traced to a reciprocal translocation involving chromosomes 9 and 22, dubbed the Philadelphia chromosome, which is observed in essentially all patients. The resulting fusion gene, BCR/ABL, encodes an activated tyrosine kinase that can act alone to induce a CML-like syndrome in mouse models. These animal models have validated BCR/ABL as a target for the development of specific pharmaceutical inhibitors. The kinase inhibitor imatinib mesylate (Gleevec) is highly specific, effective, and minimally toxic, but may not effect cures as a single agent, particularly in patients with accelerated and blast-phase disease. Resistance to imatinib can confound therapy. Surprisingly, a high percentage of resistant cases manifest intact or augmented BCR/ABL signaling, suggesting that this oncoprotein, or signaling pathways emanating from it, remain viable targets. Combination chemotherapy is under active investigation, and among the most compelling strategies is dual treatment with agents that both target BCR/ABL signal transduction. BCR/ABL activates Ras, and compounds designed to antagonize Ras function called farnesyl transferase inhibitors (FTIs) have shown potent activity in vitro and in animal models of BCR/ABL-induced leukemia. Initial clinical trials in patients with refractory acute myeloid leukemia and CML in blast crisis have shown significant activity, suggesting that trials combining imatinib and FTIs are warranted.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Acute lung injury is a life-threatening condition characterized by surfactant dysfunction and raised secretory phospholipase A2 (sPLA2) activity. Varespladib is a sPLA2 inhibitor shown to be effective in animal models of acute lung injury. We aimed at investigating the effect of co-administration of surfactant and varespladib on sPLA2 activity. Alveolar macrophages were cultured and stimulated with lipopolysaccharide and then treated with either varespladib, surfactant, varespladib followed by surfactant or nothing. sPLA2 activity, free fatty acids, tumour necrosis factor- (TNF-) and protein concentrations were measured in culture supernatants. Treatment with varespladib (p=0.019) and varespladib + surfactant (p=0.013), reduced the enzyme activity by approximately 15% from the basal level measured in the untreated cultures. Surfactant, varespladib and varespladib + surfactant, respectively decreased free fatty acids by -45% (p=0.045), - 62% (p=0.009) and -48% (p=0.015), from the baseline concentration of the untreated cultures. Varespladib and poractant- co-administration reduces sPLA2 activity and free fatty acids release in cultured rat alveolar macrophages, although a clear drug synergy was not evident. Since co-administration may be useful to reduce inflammation and surfactant inactivation in acute lung injury, further in vivo studies are warranted to verify its clinical usefulness.
Output: Which enzyme is inhibited by Varespladib?
Human alpha-galactosidase A (EC 3.2.1.22; alpha-Gal A) is the lysosomal exoglycosidase responsible for the hydrolysis of terminal alpha-galactosyl residues from glycoconjugates and is the defective enzyme causing Fabry disease (McKusick 301500). An unusally elevated level of plasma alpha-Gal A activity (> 2.5 times the normal mean) was detected in two unrelated normal males and the elevated activities were inherited as X-linked traits in their families. Sequencing of the alpha-Gal A coding region, intron/exon boundaries and 5'-flanking region from the proband identified a single mutation, a G-->A transition 30 nt upstream from the initiation of translation codon in exon 1. The -30G-->A mutation occurred in a putative NF kappa B/Ets consensus binding site that was recently shown to inhibit protein binding to the 5'-untranslated region of the gene, providing a possible explanation for its high activity. To further characterize the mutation, the mRNA and protein expressed by this variant allele were studied. Purified plasma and lymphoblast alpha-Gal A activity from individuals with the -30G-->A mutation had normal physical and kinetic properties. In vitro translation of mRNAs from the cloned normal and high plasma activity alleles resulted in similar levels of alpha-Gal A protein, indicating that this mutation did not enhance translation. These findings suggest that the -30G-->A mutation in the 5'-untranslated region of the alpha-Gal A gene enhances transcription, presumably by interfering with the binding of negatively-acting transcription factors which normally decrease alpha-Gal A expression in various cells. Preliminary studies of the frequency of the -30G-->A mutation in 395 unrelated normal males of mixed ancestry revealed two additional unrelated individuals who had high plasma enzymatic activity and the mutation, confirming the effect of this mutation on enzyme expression and suggesting that about 0.5% of normal individuals have high plasma alpha-Gal A activity due to this variant allele.
Output: Which is the defective protein causing the lysosomal storage disease Fabry?
Osteoporosis is characterised by a progressive loss of bone mass and microarchitecture which leads to increased fracture risk. Some of the drugs available to date have shown reductions in vertebral and non-vertebral fracture risk. However, in the ageing population of industrialised countries, still more fractures happen today than are avoided, which highlights the large medical need for new treatment options, models, and strategies. Recent insights into bone biology, have led to a better understanding of bone cell functions and crosstalk between osteoblasts, osteoclasts, and osteocytes at the molecular level. In the future, the armamentarium against osteoporotic fractures will likely be enriched by (1.) new bone anabolic substances such as antibodies directed against the endogenous inhibitors of bone formation sclerostin and dickkopf-1, PTH and PTHrp analogues, and possibly calcilytics; (2.) new inhibitors of bone resorption such as cathepsin K inhibitors which may suppress osteoclast function without impairing osteoclast viability and thus maintain bone formation by preserving the osteoclast-osteoblast crosstalk, and denosumab, an already widely available antibody against RANKL which inhibits osteoclast formation, function, and survival; and (3.) new therapeutic strategies based on an extended understanding of the pathophysiology of osteoporosis which may include sequential therapies with two or more bone active substances aimed at optimising the management of bone capital acquired during adolescence and maintained during adulthood in terms of both quantity and quality. Finally, one of the future challenges will be to identify those patients and patient populations expected to benefit the most from a given drug therapy or regimen. The WHO fracture risk assessment tool FRAX® and improved access to bone mineral density measurements by DXA will play a key role in this regard.
Output: To the ligand of which receptors does Denosumab (Prolia) bind?
Can You Feel Anything When I Do This? is a collection of science fiction short stories by American writer Robert Sheckley, published in December 1971 by Doubleday.
Output: What business published Can You Feel Anything When I Do This??
Elisa Casanova (born 26 November 1973) is an Italian female former water polo player.
Output: What is the sex or gender of Elisa Casanova?
The Beginning of the Civil Rights Movement In 1955,bus seats for African Americans and whites were separated in parts of the U.S.. On December 1,1955,in the city of Montgomery,Alabama,a conflict,or disagreement,started when an African American woman named Rosa Parks refused to give her bus seat to a white man and go to the back of the bus. The police took 42yearold Parks to jail. The African American community was extremely angry. They had a meeting and decided to work together to protest discrimination. They agreed to boycott the buses on the day that Parks went to court. The day was a success. Empty buses drove through the streets. The city lost money. The community decided to continue the boycott. They elected a man named Martin Luther King,Jr. to be the leader. The boycott continued. It was difficult for African Americans to get to work without buses,but they didn't stop the boycott. The city continued to lose money. Finally,the U.S. Supreme Court decided that Montgomery's bus laws were unfair and gave the African American community equal right. On December 21,1956,the bus boycott ended. The Montgomery Bus Boycott was the beginning of the Civil Rights Movement. The movement eventually led to the Civil Rights Act in 1964,a set of laws that made discrimination a crime. During the Montgomery Bus Boycott,people worked together to change the government. Today,people in the U.S. continue to work together for a change. Now hundreds of organizations and community groups work to protect the rights of U.S. citizens and residents.
Output: What is the final result of the Civil Rights Movement?
The Strelna River originates on the Keivy and flows into the White Sea.
Output: What river does Strelna River connect to?
Muenke syndrome, defined by heterozygosity for a Pro250Arg substitution in fibroblast growth factor receptor 3 (FGFR3), is the most common genetic cause of craniosynostosis in humans. We have used gene targeting to introduce the Muenke syndrome mutation (equivalent to P244R) into the murine Fgfr3 gene. A rounded skull and shortened snout (often skewed) with dental malocclusion was observed in a minority of heterozygotes and many homozygotes. Development of this incompletely penetrant skull phenotype was dependent on genetic background and sex, with males more often affected. However, these cranial abnormalities were rarely attributable to craniosynostosis, which was only present in 2/364 mutants; more commonly, we found fusion of the premaxillary and/or zygomatic sutures. We also found decreased cortical thickness and bone mineral densities in long bones. We conclude that although both cranial and long bone development is variably affected by the murine Fgfr3(P244R) mutation, coronal craniosynostosis is not reliably reproduced.
Output: Which gene is associated with Muenke syndrome?
Sir Amyas Pollard, 3rd Baronet (1616-1701) was an English gentleman of Devon and a baronet.
Output: What was the title that Sir Amyas Pollard, 3rd Baronet held?
Infectious Mononucleosis (IM), a benign lymphoproliferative disease, is the best known clinical syndrome caused by Epstein-Barr Virus (EBV). It usually resolves over a period of weeks or months without sequelae but may occasionally be complicated by a wide variety of neurologic, hematologic, hepatic, respiratory, and psychological complications. In this report we describe a patient with acute hepatitis following EBV-IM in a previously healthy woman. A 26-year-old woman who presented with fever, generalized weakness, nausea, sore throat, yellowing of skin, and a generalized skin rash was admitted to our clinic. Tonsillar enlargement, pharyngeal erythema, palatal petechiae, lymphadenopathy, and jaundice were noted. Significant atypical lymphocytes ( > 10%) were seen on the peripheral blood smear. Liver function tests such as ALT: 303 U/L, AST: 172 U/L, ALP: 193 U/L and total bilirubin: 7.3 mg/dl were elevated. Serological tests for EBV infection were consistent with acute infection (EBV virus capsid antigen was reactive with IgM and IgG antibodies). The Monospot test was also positive. On the seventh day, liver function tests and bilirubin had risen to peak level and platelets were decreased. The patient was managed supportively and her critical condition improved and was finally stabilized. Although the prognosis for IM is very favorable, a variety of acute complications may occur.
Output: Which virus can be diagnosed with the monospot test?
Tweetie Pie won the Academy Award for Best Animated Short Film, breaking Tom and Jerry's streak of four consecutive wins on the category.
Output: What award was Tweetie Pie nominated for?
The Caledonian Railway 179 Class (nicknamed Oban bogie) was a class of 4-4-0 steam locomotives designed by George Brittain for the Caledonian Railway (CR) and introduced in 1882.
Output: Which was the official year for the approval of Caledonian Railway 179 Class?
Patti Page, the top-selling female artist of the 1950s with more than 100 million records sold, died on January 2nd, 2013, when she was 85. She was one of the most beloved singers of the post-war era. Take her "Tennessee Waltz" for example, it sold more than 10 million copies and was her biggest hit . Born in Claremore, Oklahoma, a small town near Tulsa, Page once dreamed of a career in commercial art. Her first job in the art department at a local radio station soon led to her performing 15-minute program on her own. At age 20, Page was discovered by big-band leader Jack Rael, who gave up his job to become her manager. The next year, she signed her first recording contract with Mercury Records and enjoyed her first hit record soon. She stayed with Mercury for the next 14 years and recorded hit after hit including: "With My Eyes Wide Open, I'm Dreaming" and "Old Cape Cod". Her last hit was "Hush... Hush, Sweet Charlotte" , recorded for the Bette Davis movie of the same name. And then, there was "Doggie in the Window". The creative tune was a huge hit, but with its repeated barking sounds and silly lyrics , the song has been used by many people as an example of all that was wrong with pop music in the early 1950s. Throughout the 1950s, Patti Page made regular appearances on a variety of television shows and in 1957 she was chosen to host the musical program "The Big Record". The following year, Page appeared in her own CBS television series "The Patti Page Show". She continued to record and perform into the 21st century, most recently releasing an album of songs for children, a Christmas record, and a new "best of" collection. Besides music, Patti Page did a bit of acting. She co-starred with the Oscar-winning Burt Lancaster in "Elmer Gantry", and also starred on stage in the musical play "Annie Get Your Gun".
Output: According to the passage, which one of her following recorded songs was criticized ?
Whaam! was first exhibited at the Leo Castelli Gallery in New York City in 1963, and purchased by the Tate Gallery, London, in 1966.
Output: What is the name of the place where Whaam! can be found?
The Battle of Crysler's Farm, also known as the Battle of Crysler's Field, was fought on 11 November 1813, during the Anglo-American War of 1812 (the name Chrysler's Farm is sometimes used for the engagement, but Crysler is the proper spelling).
Output: On what date did Battle of Crysler's Farm end?
The susceptibility to arbekacin (ABK) of methicillin-resistant Staphylococcus aureus (MRSA) was investigated to find out how it related to aac(6')/aph(2") gene. In 49 isolates of MRSA for which MIC of ABK ranged from 0.125 to 64 micrograms/ml, the MICs of ABK for 38 strains carrying aac(6')/aph(2") gene were widely distributed from 0.25 to 64, whereas those for 11 strains without that gene were all < or = 0.5 microgram/ml. Residual rate of ABK activity was higher than that of gentamicin after the reaction with each crude enzyme preparation extracted from 3 isolates of MRSA, carrying aac(6')/aph(2") and aad(4',4") genes. Furthermore, 97 strains of MRSA isolated at Kanagawa prefecture in Japan in 1999 were all sensitive to ABK, although 28 strains of them carried aac(6')/aph(2") gene. These results showed that ABK resistance was not necessarily related to carrying aac(6')/aph(2") gene in clinical isolates of MRSA.
Output: What is MRSA?
Alzheimer's disease (AD) is the most common cause of dementia in humans. A pathological hallmark in the brain of an AD patient is extracellular amyloid plaques formed by accumulated beta-amyloid protein (Abeta), a metabolic product of amyloid precursor protein (APP). Studies have revealed a strong genetic linkage in the early-onset familial form (<60 years old) of AD. For example, some mutant APPs are transmitted dominantly and are segregated with inheritance of early onset AD. These mutants facilitate Abeta production. The "Swedish" mutations (APP(SW)) and the "London" mutation (APP(LON)) are examples of these mutants. Selective silencing of these mutant alleles holds therapeutic promise for AD. Here we show that the expression of the mutant APPs was selectively inhibited by RNA interference. The best selectivity was obtained when the mismatches were centrally placed in the antisense strand of small interfering RNAs. Introducing an additional mismatch in the antisense strand may improve the selectivity. The addition of a G at 5' end of the antisense strand may enhance the efficacy of gene silencing by RNA interference. Our results illustrate the guiding principles for selection of targeted sequences to achieve allele-specific silencing. The sequences that are effective to silence APP(SW) and APP(LON) as identified in this study may be useful in both in vivo and in vitro studies to investigate the pathophysiological role of APP(SW) and APP(LON) in AD development.
Output: Which disease the London mutation involved in?
Contrary to earlier beliefs, viruses are not the smallest causative agents of infectious diseases. Single-stranded RNAs as small as 246 nucleotides exist in certain higher plants and cause more than a dozen crop diseases. These RNAs have been termed viroids. Despite their extremely limited information content, viroids replicate autonomously in susceptible cells--that is, they do not require helper functions from simultaneously replicating conventional viruses. Viroids are covalently closed circular molecules with a characteristic rodlike secondary structure in which short helical regions are interrupted by internal and bulge loops. Viroids are not translated; they are replicated by a host enzyme (or enzymes) (probably RNA polymerase II) via oligomeric RNA intermediates by a rolling circle mechanism. Viroidlike satellite RNAs resemble viroids in size and molecular structure, but are found within the capsids of specific helper viruses on which they depend for their own replication. These RNAs are of great interest to molecular biology for at least two reasons: 1) they are the smallest and simplest replicating molecules known, and 2) they may represent living fossils of precellular evolution in a hypothetical RNA world.
Output: Which are the smallest known subviral pathogens of plants?
Do you have imagination? Do you like to solve problems? Can you? If so, you could be the next great inventor. "But I'm just a kid",you might be! Don't worry about a little thing like age. For example, one famous inventor-- Benjamin Franklin--got his start when he was only 12. At that young age, he created paddles for his hands to help him swim faster. Finally his creation led to what we know is called flippers! So you don't have to be adult to be an inventor. One thing you do need, though, is something that kids have plenty of: curiosity and imagination. Kids are known for looking at things in new and unique ways. So what should you do if you have what is a great idea for an invention? Talk to a friend or family member about it. Get input from others about your idea. Then ask them to help you create a working model--called a prototype of your idea. Once you have a prototype, you can test it. Sometimes your idea turns out to be not as great as you thought. At other times, though, you realize it is a good idea and your prototype can help you figure out how to make it even better. If your idea is really a good one, an adult can help you contact companies that might be interested in it. You will also want an adult's help to get a patent for your idea, so that it is protected and can't be stolen by someone else. If you need some inspiration, consider these kids and their inventions: Jeanie Low invented the Kiddie Stool when she was just 11. It's a folding stool that fits under the kitchen sink. Kids can unfold it and use it to reach the sink all by themselves. At the age of 15, Louis Braille invented the system named after him that allows the blind to read. Chelsea Lanmon received a patent when she was just 8 for the "pocket diaper ",a new type of diaper that includes a pocket for holding baby wipes and powder.
Output: Who invented something that helps the blind to read?
The Face of Battle is a 1976 non-fiction book on military history by the English military historian John Keegan.
Output: Who is the writer of The Face of Battle?
Power Broker, Inc. is a fictional criminal corporation in the Marvel Universe which provides individuals with superhuman physical abilities for a price.
Output: What is the name of the fictional universe that Power Broker is from?
Justo Perez Santiago (August 7, 1895 -- 1979) later known as Fray Justo Perez de Urbel y Santiago O.S.B. was a Spanish Roman Catholic clergyman (Order of Saint Benedict) and medievalist, first abbot of the Monastery of the Holy Cross of the Valle de los Caidos, member of the Consejo Nacional del Movimiento (the first quasi-parliamentary assembly of Francoist Spain), later a Procurador en Cortes (member of the longer-lived Francoist assembly established after the end of the Spanish Civil War) and distinguished scholar of medieval Castile.
Output: To which religious order did Justo Pérez de Urbel belong?
Chronic myelogenous leukemia (CML) is characterized by the presence of a Bcr-Abl fusion protein with deregulated tyrosine kinase activity that is required for maintaining the malignant phenotype. Imatinib, a selective inhibitor of Bcr-Abl, induces major cytogenetic remission (MCR) or complete cytogenetic remission (CCR) in the majority of patients with CML in first chronic phase. However, thorough re-evaluation of cytogenetics in a cohort of patients in MCR or CCR demonstrated clonal karyotypic abnormalities in more than 10% of cases, some of which were clinically associated with a myelodysplastic syndrome (MDS). Further analysis identified previous exposure to cytarabine and idarubicin as significant risk factors for the subsequent occurrence of abnormalities in Philadelphia chromosome-negative (Ph-) cells. To investigate if cytogenetically normal but clonal hematopoiesis might be present in other patients in cytogenetic remission, we studied X-chromosome inactivation as a marker of clonality by polymerase chain reaction analysis of the human androgen receptor (HUMARA). We find that imatinib restores a polyclonal pattern in most patients in CCR and MCR. Nonetheless, our results are consistent with the notion that targeted therapy of CML with imatinib favors the manifestation of Ph- clonal disorders in some patients. They indicate that patients on imatinib should be followed with conventional cytogenetics, even after induction of CCR.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
"When I grow up, I want to be..." Almost all of us have thought about, or been asked to think about, our future careers. Our answers may differ greatly. Even now your aspirations may have changed from when you were in primary school. However, it seems career options aren't only based on personal taste. In a survey carried out by Teens, doctors, lawyers, and bankers were some of most popular careers that people said they hoped to follow. This is in line with a similar survey carried out in the UK in May 2011 by job website monster. Co.uk, in which medicine was the top choice among UK teenagers aged between 13 and 17. Medicine and law are two of the oldest and best known professions. Their prestige may come from the fact that doctors and lawyers are some of the most esteemed members of society, and they make good money. Joining these high-profile professions is often seen as a sign of upward social mobility. It is equally unsurprising that banking is now one of the most common career choices. Youngsters worldwide think of banking and see the money rolling in. Wealth is increasingly becoming one of the most important indicators of a successful career. British young men list the UK tycoon Alan Sugar, Microsoft founder Bill Gates and Facebook chief Mark Zuckerberg as their top role models "for their wealth". Just as Chinese teenagers see being a banker as a good and fun pathway to "wealth". However, not every child has the makings of doctor, lawyer, or banker. They are those who see fulfillment and happiness in other areas, and many teenagers dare to ink more individuality into their career options. As the Teens' survey discovered, a variety of unconventional jobs---coffee shop owner, gourmet ,waiter at a fast food restaurant---are among teenagers' career choices. They can be equally interesting and rewarding jobs. With every choice comes responsibility and challenge, and all career paths require specific education and training, you have to learn to balance optimism and confidence with being realistic about your particular talents and skills.
Output: What is the top career choice among UK teenagers aged between 13 and 17 according to the article?
Decameron Nights is a 1953 anthology Technicolor film based on three tales from The Decameron by Giovanni Boccaccio, specifically the ninth and tenth tales of the second day and the ninth tale of the third.
Output: The Decameron Nights is based upon what?
Patients with multiple myeloma (MM) experience pathologic fractures, bone pain, hypercalcemia, neurologic symptoms, and renal insufficiency with substantial morbidity and mortality. Bisphosphonates have been used successfully for the management of MM-related bone disease. Increased incidence of osteonecrosis of the jaw has been observed in patients with cancer receiving bisphosphonate therapy. Recent advances in the pathobiology of MM-related bone disease and other cancer-related bone metastases have led to the identification of novel therapeutic targets, such as receptor activator of nuclear factor-kappaB (RANK); its ligand (RANKL); and a decoy receptor, osteoprotegerin, for the development of potential targeted agents. Initials studies have demonstrated that targeting RANK/ RANKL signaling with the fully human monoclonal antibody denosumab prevented skeletal complications in patients with MM and other cancers with bone metastases. Ongoing studies evaluating the clinical utility of denosumab in cancer- related bone destruction have been discussed. In addition, several potential targets, such as macrophage inflammatory protein-1alpha, chemokine receptors 1 and 5, interleukin-3, and Wnt signaling, are b riefly described.
Output: To the ligand of which receptors does Denosumab (Prolia) bind?
An experiment was carried out at British school into the performance of new pupils. At the start of the year, the pupils were each given a _ , ranging from "excellent prospect" to "unlikely to do well". These were totally untrue ratings and did not reflect how well the pupils had previously performed. However, these ratings were given to the teachers. At the end of the year, the experimenters compared the pupils' performance with the ratings. Despite their real abilities, there was an astonishingly high connection between performance and ratings. It seems that people perform as well as we expect them to. The Self-fulfilling Effect is also known as the Pygmalion Effect. This comes from an old Greek story. The story was also the basis of George Bernard Shaw's play "Pygmalion", later turned into the musical "My Fair Lady". In Shaw's play, Professor Henry Higgins claims he can turn a Cockney flower girl, Eliza Doolittle into a duchess. But, as Eliza herself points out to Higgins' friend Pickering, it isn't what she learns or does that determines whether she will become a duchess, but how she's treated. The implication of the Pygmalion Effect for leaders and managers is massive. It means that the performance of your team depends less on them than it does on you. The performance you get from people is no more or less than what you expect, which means you must always expect the best. As Goethe said, "Treat a man as he is and he will remain as he is. Treat a man as he can and should be and he will become as he can and should be."
Output: What's the passage mainly about?
The Ballpark at Jackson was built by the municipal government of Jackson, Tennessee and is the home of the Jackson Generals of the Southern League.
Output: What team uses The Ballpark at Jackson?
''Halle Berry (She's Fine)'' is the lead single by American rapper Hurricane Chris from his second studio album, Unleashed, The song features guest appearances from a local rapper, named Superstarr.
Output: What artist created Halle Berry (She's Fine)?