niryuu/sni-each-converted huggingface dataset:
A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as a mechanism for the treatment of autoimmune diseases such as asthma, rheumatoid arthritis, and SLE. Fostamatinib, a Syk inhibitor that successfully completed phase II clinical trials, also exhibits some undesirable side effects. More selective Syk inhibitors could offer safer, alternative treatments. Through a systematic evaluation of the kinome, we identified Pro455 and Asn457 in the Syk ATP binding site as a rare combination among sequence aligned kinases and hypothesized that optimizing the interaction between them and a Syk inhibitor molecule would impart high selectivity for Syk over other kinases. We report the structure-guided identification of three series of selective spleen tyrosine kinase inhibitors that support our hypothesis and offer useful guidance to other researchers in the field.
Output: Which enzyme is inhibited by a drug fostamatinib?
Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) are dominant regulators of bone resorption. Many hormones, cytokines and growth factors mediate bone resorption by altering the ratio of RANKL to OPG. RANKL and OPG expression is also altered in numerous bone diseases, and these changes can reflect disease etiology or compensatory responses to disease. RANKL stimulates osteoclast formation, function and survival, and each of these effects is inhibited by OPG. OPG suppresses bone resorption and increases the density, area and strength of both cancellous and cortical bone. Denosumab (AMG 162), a fully human monoclonal antibody to RANKL, shares the pharmacologic attributes of OPG but has a significantly longer half-life that allows less frequent administration.
Output: To the ligand of which receptors does Denosumab (Prolia) bind?
Background Inappropriate use of antibiotic treatment for pharyngitis by community pharmacists is prevalent in developing countries. Little is known about how the pharmacists identify patients with bacterial pharyngitis. Objective To ascertain the appropriateness of diagnosis of streptococcal pharyngitis among Thai community pharmacists according to the Centor criteria and to identify factors related to antibiotic dispensing. Setting 1040 Thai community pharmacists. Method A cross-sectional survey of community pharmacists was conducted in November 2012 to March 2013. The self-administered questionnaires were mailed to 57% of community pharmacists in the south of Thailand (n=1040). The survey included questions on diagnosis of streptococcal pharyngitis, knowledge on pharyngitis, and attitudes and control beliefs regarding antibiotic dispensing. Main outcome measure The appropriateness of diagnosis of streptococcal pharyngitis according to the original and modified Centor criteria and determinants of antibiotic dispensing including demographic characteristics of pharmacists, knowledge on pharyngitis, and attitudes and control beliefs on antibiotic dispensing. Results Approximately 68% completed the questionnaires (n=703). Compared to the pharmacists who reported not dispensing antibiotics in the hypothetical case with common cold, those reported dispensing antibiotics were more likely to consider the following conditions-presence of cough, mild sore throat and patients with age >60years as cues for diagnosis of streptococcal pharyngitis (p<0.05). The use of fewer scores of the clinical prediction rules for diagnosis was observed in antibiotic dispensers, compared to who did not do so (p<0.005). Antibiotic dispensing was positively associated with period of dispensing experience (>5years) [odds ratio (OR) 1.52; 95% confidence interval (CI) 1.03-2.23], belief that antibiotics could shorten duration of pharyngitis (OR 1.48; 95% CI 1.11-1.99), belief that antibiotics could prevent the complications (OR 1.44; 95% CI 1.09-1.91) and belief that dispensing antibiotics could satisfy the patients (OR 1.31; 95% CI 1.01-1.71). Nonetheless, antibiotic dispensing was negatively associated with knowledge about pharyngitis (OR 0.83; 95% CI 0.75-0.93). Conclusion Pharmacists who are knowledgeable on the Centor criteria are more likely to appropriately diagnose streptococcal pharyngitis and less likely to dispense antibiotics in such case.
Output: Centor criteria are used for which disease?
6141 Durda (1992 YC3) is a Mars-crossing asteroid discovered on December 26, 1992 by Spacewatch at Kitt Peak.
Output: Who was the original discoverer of 6141 Durda?
The 1988 Dungeons & Dragons role-playing game module Ruins of Adventure was produced using the same adventure scenario as Pool of Radiance, using the same plot, background, setting, and many of the same characters as the computer game.
Output: The Pool of Radiance is based upon what?
To explore potential therapeutic strategies for interrupting the interleukin-6 (IL-6) signaling pathway, we measured IL-6 expression in ovarian cancer tissues, and evaluated the effects of a monoclonal anti-IL-6 antibody; siltuximab (CNTO 328), on levels of IL-6-induced Stat3 phosphorylation, Stat3 nuclear translocation, and Stat3 downstream antiapoptotic genes. We then looked for enhancing paclitaxel sensitivity in multidrug-resistant ovarian cancer cell lines. Expressions of IL-6 in ovarian cancer patient specimens were assessed by immunohistochemistry. Effects of siltuximab on IL-6-induced activation of Stat3 in an ovarian cancer cell line were determined by Western blot and real-time analysis of Stat3 nucleocytoplasmic translocation. Influence of combination of siltuximab and paclitaxel on tumor growth was evaluated in a xenograft mouse mode in vivo. Metastatic and drug-resistant recurrent tumors have significantly higher IL-6 expression when compared with the matched primary tumors. Siltuximab specifically suppressed IL-6-induced Stat3 phosphorylation and Stat3 nuclear translocation. Treatment with siltuximab significantly decreased the levels of Stat3 downstream proteins such as MCL-1, Bcl-X(L), and survivin. Treatment with siltuximab reduced expression of multiple IL-6-induced genes in these cell lines. Furthermore, siltuximab increased the cytotoxic effects of paclitaxel in a paclitaxel resistant ovarian cancer cell line in vitro, but combination therapy with siltuximab did not have a significant effect on paclitaxel resistant tumor growth in vivo. These results show that siltuximab effectively block the IL-6 signaling pathways and IL-6-induced gene expression. Blockage of IL-6 signaling may provide benefits for the treatment of ovarian cancer.
Output: Which interleukin is blocked by Siltuximab?
Imatinib induces a durable response in most patients with Philadelphia chromosome-positive chronic myeloid leukemia, but it is currently unclear whether imatinib reduces the leukemic stem cell (LSC) burden, which may be an important step toward enabling safe discontinuation of therapy. In this article, we use mathematical models of BCR-ABL levels to make inferences on the dynamics of LSCs. Patients with at least 1 BCR-ABL transcript measurement on imatinib were included (N = 477). Maximum likelihood methods were used to test 3 potential hypotheses of the dynamics of BCR-ABL transcripts on imatinib therapy: (i) monoexponential, in which there is little, if any, decline in BCR-ABL transcripts; (ii) biexponential, in which patients have a rapid initial decrease in BCR-ABL transcripts followed by a more gradual response; and (iii) triexponential, in which patients first exhibit a biphasic decline but then have a third phase when BCR-ABL transcripts increase rapidly. We found that most patients treated with imatinib exhibit a biphasic decrease in BCR-ABL transcript levels, with a rapid decrease during the first few months of treatment, followed by a more gradual decrease that often continues over many years. We show that the only hypothesis consistent with current data on progenitor cell turnover and with the long-term, gradual decrease in the BCR-ABL levels seen in most patients is that these patients exhibit a continual, gradual reduction of the LSCs. This observation may explain the ability to discontinue imatinib therapy without relapse in some cases.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
RNA editing by deamination of specific adenosine bases to inosines during pre-mRNA processing generates edited isoforms of proteins. Recoding RNA editing is more widespread in Drosophila than in vertebrates. Editing levels rise strongly at metamorphosis, and Adar(5G1) null mutant flies lack editing events in hundreds of CNS transcripts; mutant flies have reduced viability, severely defective locomotion and age-dependent neurodegeneration. On the other hand, overexpressing an adult dADAR isoform with high enzymatic activity ubiquitously during larval and pupal stages is lethal. Advantage was taken of this to screen for genetic modifiers; Adar overexpression lethality is rescued by reduced dosage of the Rdl (Resistant to dieldrin), gene encoding a subunit of inhibitory GABA receptors. Reduced dosage of the Gad1 gene encoding the GABA synthetase also rescues Adar overexpression lethality. Drosophila Adar(5G1) mutant phenotypes are ameliorated by feeding GABA modulators. We demonstrate that neuronal excitability is linked to dADAR expression levels in individual neurons; Adar-overexpressing larval motor neurons show reduced excitability whereas Adar(5G1) null mutant or targeted Adar knockdown motor neurons exhibit increased excitability. GABA inhibitory signalling is impaired in human epileptic and autistic conditions, and vertebrate ADARs may have a relevant evolutionarily conserved control over neuronal excitability.
Output: Which is the major RNA editing enzyme in Drosophila melanogaster?
Chronic myeloid leukaemia (CML) is characterised by the occurrence of the Philadelphia (Ph) chromosome (9/22 translocation) and the formation of a fusion protein--the BCR-ABL transcript with constitutive activation of the BCR-ABL tyrosine kinase and consequent changes in the intracellular signal transduction, which is responsible for the deregulated myeloid cell proliferation. STI571 (signal transduction inhibition number 571) is a potent and selective inhibitor of the BCR-ABL tyrosine kinase. In the chronic phase of the disease, normal peripheral blood values are achieved within the first month of treatment in the large majority of patients and in many patients also a cytogenic response within the following months. The results in the advanced phase are far less favourable, which is explained by the development of resistance owing to reactivation of the BCR-ABL signal transduction. Side effects are primarily nausea, vomiting, various rashes, oedema, most often in the periorbital region, and musculoskeletal symptoms, including muscle cramps. Perspectives for treatment with STI571 are described, as are combinations with alpha-interferon and other cytostatics with a synergistic profile.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Dreimal sieben Gedichte aus Albert Girauds ''Pierrot lunaire'' (''Three times Seven Poems from Albert Giraud's 'Pierrot lunaire'''), commonly known simply as Pierrot Lunaire, Op. 21 (''Moonstruck Pierrot'' or ''Pierrot in the Moonlight''), is a melodrama by Arnold Schoenberg.
Output: Which is the basis of Pierrot Lunaire?
Since the time of Copernicus, Kepler, and Galileo, we have learned a lot more about our solar system. Astronomers have discovered two more planets (Uranus and Neptune), five dwarf planets (Ceres, Pluto, Makemake, Haumea, and Eris), more than 150 moons, and many, many asteroids and other small objects. Although the Sun is just an average star compared to other stars, it is by far the largest object in the solar system. The Sun is more than 500 times the mass of everything else in the solar system combined! Table 1.1 gives data on the sizes of the Sun and planets relative to Earth. Object Mass (Relative to Earth) Sun Mercury Venus Earth 333,000 Earths mass 0.06 Earths mass 0.82 Earths mass 1.00 Earths mass Diameter of Planet (Relative to Earth) 109.2 Earths diameter 0.39 Earths diameter 0.95 Earths diameter 1.00 Earths diameter Object Mass (Relative to Earth) Mars Jupiter Saturn Uranus Neptune 0.11 Earths mass 317.8 Earths mass 95.2 Earths mass 14.6 Earths mass 17.2 Earths mass Diameter of Planet (Relative to Earth) 0.53 Earths diameter 11.21 Earths diameter 9.41 Earths diameter 3.98 Earths diameter 3.81 Earths diameter Distances in the solar system are often measured in astronomical units (AU). One astronomical unit is defined as the distance from Earth to the Sun. 1 AU equals about 150 million km, or 93 million miles. Table 1.2 shows the distances to the planets (the average radius of orbits) in AU. The table also shows how long it takes each planet to spin on its axis (the length of a day) and how long it takes each planet to complete an orbit (the length of a year); in particular, notice how slowly Venus rotates relative to Earth. Planet Mercury Venus Earth Mars Jupiter Saturn Uranus Neptune Average Distance from Sun (AU) 0.39 AU 0.72 1.00 1.52 5.20 9.54 19.22 30.06 Length of Day (In Earth Days) 56.84 days 243.02 1.00 1.03 0.41 0.43 0.72 0.67 Length of Year (In Earth Years) 0.24 years 0.62 1.00 1.88 11.86 29.46 84.01 164.8 Click image to the left or use the URL below. URL:
Output: the sun is _________________________ million miles from earth.
The Paraul Malurilor is a tributary of the Dragan River in Romania.
Output: Which country is Pârâul Malurilor in?
"Iris scan , please," the bank's computer voice tells you. You step up and the computer reads your eye, comparing it to the stored file it has of your iris. The images had better match---otherwise, you won't be able to get your money. Iris scanning and other technologies, such as fingerprint and voice scanning, have appeared in many science fiction movies in the past. Today, these advanced technologies are part of the real world. They are common at work, the bank, the airport, and your local prison. The iris scan, fingerprint scan, and voice scan are all examples of biometrics , a fast developing area of automatic personal identification technology. Basically, biometrics uses various ways to verify a person's identity, based on the individual's unique characteristics, including fingerprints, signature, and so on. Biometrics identification systems have a number of advantages over password systems. The primary advantage is that an individual has to be physically present in order to be identified. Another important advantage is that there are no passwords to remember, forget, lose, or steal. The voice scan is the simplest and most affordable form of biometrics. It only requires a computer, a microphone, and the correct software. The software records a subject's voice and then compares it to a stored voice sample for identification purpose. For additional safety, fingerprint and handprint scans can also be employed. Fingerprint scans take the image of a fingerprint and compare it to a stored file of prints. Handprint scans identify the unique features of a hand.
Output: Which is the most accurate form of biometrics?
DNA must replicate (copy) itself so that each resulting cell after mitosis and cell division has the same DNA as the parent cell. All these cells, the parent cell and the two new daughter cells, are genetically identical. DNA replication occurs during the S phase (the Synthesis phase) of the cell cycle, before mitosis and cell division. The base pairing rules are crucial for the process of replication. DNA replication occurs when DNA is copied to form an identical molecule of DNA. The general steps involved in DNA replication are as follows: 1. The DNA helix unwinds like a zipper as the bonds between the base pairs are broken. The enzyme DNA Helicase is involved in breaking these bonds. 2. The two single strands of DNA then each serve as a template for a new stand to be created. Using DNA as a template means that on the new strand, the bases are placed in the correct order because of the base pairing rules. Recall that A and T are complementary bases, as are G and C. As a template strand is read, the new strand is created. If ATGCCA is on the "template strand," then TACGGT will be on the new DNA strand. The enzyme DNA Polymerase reads the template and builds the new strand of DNA. 3. The new set of nucleotides then join together to form a new strand of DNA. The process results in two DNA molecules, each with one old strand and one new strand of DNA. This process is known as semiconservative replication because one strand is conserved (kept the same) in each new DNA molecule ( Figure 1.1). DNA replication occurs when the DNA strands unzip, and the original strands of DNA serve as a template for new nucleotides to join and form a new strand.
Output: what is the first step in dna replication?
Upon infection of a mammalian host, Bacillus anthracis responds to host cues, and particularly to elevated temperature (37C) and bicarbonate/CO2 concentrations, with increased expression of virulence factors that include the anthrax toxins and extracellular capsular layer. This response requires the presence of the pXO1 virulence plasmid-encoded pleiotropic regulator AtxA. To better understand the genetic basis of this response, we utilized a controlled in vitro system and Next Generation sequencing to determine and compare RNA expression profiles of the parental strain and an isogenic AtxA-deficient strain in a 2 2 factorial design with growth environments containing or lacking carbon dioxide. We found 15 pXO1-encoded genes and 3 chromosomal genes that were strongly regulated by the separate or synergistic actions of AtxA and carbon dioxide. The majority of the regulated genes responded to both AtxA and carbon dioxide rather than to just one of these factors. Interestingly, we identified two previously unrecognized small RNAs that are highly expressed under physiological carbon dioxide concentrations in an AtxA-dependent manner. Expression levels of the two small RNAs were found to be higher than that of any other gene differentially expressed in response to these conditions. Secondary structure and small RNA-mRNA binding predictions for the two small RNAs suggest that they may perform important functions in regulating B. anthracis virulence. A majority of genes on the virulence plasmid pXO1 that are regulated by the presence of either CO2 or AtxA separately are also regulated synergistically in the presence of both. These results also elucidate novel pXO1-encoded small RNAs that are associated with virulence conditions.
Output: Which metabolite activates AtxA?
USA-100 was launched at 03:40:01 UTC on 10 March 1994, atop a Delta II carrier rocket, flight number D226, flying in the 7925-9.5 configuration.
Output: When was the launch date of USA-100?
Alpha-synuclein accumulates in the brains of sporadic Parkinson's disease patients as a major component of Lewy bodies, and mutations in alpha-synuclein are associated with familial forms of Parkinson's disease. The pathogenic mechanisms that precede and promote the aggregation of alpha-synuclein into Lewy bodies in neurons remain to be determined. Here, we constructed a series of alpha-synuclein-enhanced green fluorescent protein (alpha-synucleinEGFP, SynEGFP) fusion proteins to address whether the Parkinson's disease-associated mutations alter the subcellular distribution of alpha-synuclein, and to use as a tool for experimental manipulations to induce aggregate formation. When transfected into mouse cultured primary neurons, the 49-kDa alpha-synucleinEGFP fusion proteins are partially truncated to a approximately 27-kDa form. This non-fluorescent carboxy-terminally modified fusion protein spontaneously forms inclusions in the neuronal cytoplasm. A marked increase in the accumulation of inclusions is detected following treatment with each of three proteasome inhibitors, n-acetyl-leu-leu-norleucinal, lactacystin and MG132. Interestingly, Ala30Pro alpha-synucleinEGFP does not form the cytoplasmic inclusions that are characteristic of wild-type and Ala53Thr alpha-synucleinEGFP, supporting the idea that the Ala30Pro alpha-synuclein protein conformation differs from wild-type alpha-synuclein. Similar inclusions are formed if alpha-synuclein carboxy-terminus is modified by the addition of a V5/6xHistidine epitope tag. By contrast, overexpression of unmodified alpha-synuclein does not lead to aggregate formation. Furthermore, synphilin-1, an alpha-synuclein interacting protein also found in Lewy bodies, colocalizes with the carboxy-terminally truncated alpha-synuclein fusion protein in discrete cytoplasmic inclusions.Our finding that manipulations of the carboxy-terminus of alpha-synuclein lead to inclusion formation may provide a model for studies of the pathogenic mechanisms of alpha-synuclein aggregation in Lewy bodies.
Output: Which is the primary protein component of Lewy bodies?
In Europe, before the outbreak of the war, the Allies had significant advantages in both population and economics. In 1938, the Western Allies had a 30 per cent larger population and a 30 per cent higher gross domestic product than the European Axis powers ; if colonies are included, it then gives the Allies more than a 5:1 advantage in population and nearly 2:1 advantage in GDP. In Asia at the same time, China had roughly six times the population of Japan, but only an 89 per cent higher GDP; this is reduced to three times the population and only a 38 per cent higher GDP if Japanese colonies are included. The United States provided about two-thirds of all the ordnance used by the Allies in terms of warships, transports, warplanes, artillery, tanks, trucks, and ammunition. Though the Allies' economic and population advantages were largely mitigated during the initial rapid blitzkrieg attacks of Germany and Japan, they became the decisive factor by 1942, after the United States and Soviet Union joined the Allies, as the war largely settled into one of attrition. While the Allies' ability to out-produce the Axis is often attributed to the Allies having more access to natural resources, other factors, such as Germany and Japan's reluctance to employ women in the labour force, Allied strategic bombing, and Germany's late shift to a war economy contributed significantly. Additionally, neither Germany nor Japan planned to fight a protracted war, and were not equipped to do so. To improve their production, Germany and Japan used millions of slave labourers; Germany used about 12 million people, mostly from Eastern Europe, while Japan used more than 18 million people in Far East Asia.
Output: In 1938, which power was stronger in population and GDP, the Axis powers or the Western Allies?
Trying to snap a three-game losing streak, the Ravens flew to Dolphin Stadium for a Week 7 duel with the Miami Dolphins. In the first quarter, Baltimore trailed early as Dolphins kicker Dan Carpenter got a 21-yard field goal. The Ravens would respond with kicker Matt Stover getting a 47-yard field goal. In the second quarter, Baltimore took the lead as LB Terrell Suggs returned an interception 44 yards for a touchdown. Miami would answer with Carpenter making a 26-yard field goal, yet the Ravens replied with rookie quarterback Joe Flacco completing an 11-yard TD pass to WR Derrick Mason. In the third quarter, Baltimore increased its lead with Stover nailing a 28-yard field goal. The Dolphins tried to rally as quarterback Chad Pennington completed a 7-yard TD pass to WR Davone Bess. Fortunately for the Ravens, in the fourth quarter, the Ravens scored on a 5-yard TD run by RB Willis McGahee.
Output: Who scored the only defensive touchdown of the game?
Cell-mediated immunity plays a crucial role in the control of many infectious diseases, necessitating the need for adjuvants that can augment cellular immune responses elicited by vaccines. It is well established that protection against one such disease, malaria, requires strong CD8(+) T cell responses targeted against the liver stages of the causative agent, Plasmodium spp. In this report we show that the dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1 (DC-CK1), which is produced in humans and acts on naive lymphocytes, can enhance Ag-specific CD8(+) T cell responses when coadministered with either irradiated Plasmodium yoelii sporozoites or a recombinant adenovirus expressing the P. yoelii circumsporozoite protein in mice. We further show that these enhanced T cell responses result in increased protection to malaria in immunized mice challenged with live P. yoelii sporozoites, revealing an adjuvant activity for DC-CK1. DC-CK1 appears to act preferentially on naive mouse lymphocytes, and its adjuvant effect requires IL-12, but not IFN-gamma or CD40. Overall, our results show for the first time an in vivo role for DC-CK1 in the establishment of primary T cell responses and indicate the potential of this chemokine as an adjuvant for vaccines against malaria as well as other diseases in which cellular immune responses are important.
Output: Which is the causative agent of malaria?
Every immigrant leads a double life. Every immigrant has a double identity and a double vision, being suspended between an old and a new home, an old and new self. The very notion of a new home, of course, is in a sense as impossible as the notion of new parents. Parents are who they are; home is what it is. Yet home, like parentage, must be legitimized through love; otherwise, it is only a fact of geography or biology. Most immigrants to America found their love of their old homes betrayed: they did not really abandon their countries; their countries abandoned them. In America, they found the possibility of a new love, the chance to nurture new selves. Not uniformly, not without exceptions. Every generation has its Know-Nothing movement. Its understandable fear and hatred of alien invasion is as true today as it always was, but in spite of all this, the American attitude remains unique. Throughout history, exile has been a disaster; America turned it into a triumph and placed its immigrants in the center of a national epic. The epic is possible because America is an idea as much as it is a country. America has nothing to do with loyalty to a dynasty and very little to do with loyalty to particular place, but everything to do with loyalty to a set of principles. To immigrants, those principles are especially real because so often they were absent or violated in their native lands. It was no accident in the '60 and '70s, when alienation was in flower, that it often seemed to be "native" Americans who felt alienated, while aliens or the children of aliens upheld the native values. The immigrant's double vision results in a special, somewhat skewed perspective on America that can mislead but that can also find revelation in the things that to native Americans are obvious. Psychiatrist Robert Coles speaks of those "who straddle worlds and make of that very experience a new world." "Home is where you are happy." Sentimental, perhaps, and certainly not conventionally patriotic, but is appropriate for a country that wrote the pursuit of happiness into its founding document. That continues for the immigrant in America, and it never stops, but it comes to rest at a certain moment. The moment is hard to pin down, but it occurs perhaps when the immigrant's double life and double vision joint together toward a single state of mind. When the old life, the old home fade into a certain unreality: places one merely visits, in fact or in the mind, practicing the tourism of memory. It occurs when the immigrant learns his ultimate lesson: above all countries, America, if loved, returns love.
Output: What can be the best title of the passage?
With regulations in place and DDT banned, the eagle population rebounded. The bald eagle can be found in growing concentrations throughout the United States and Canada, particularly near large bodies of water. In the early 1980s, the estimated total population was 100,000 individuals, with 110,000115,000 by 1992; the U.S. state with the largest resident population is Alaska, with about 40,00050,000, with the next highest population the Provinces and territories of Canada of British Columbia with 20,00030,000 in 1992. Obtaining a precise count of bald eagles population is extremely difficult. The most recent data submitted by individual states was in 2006, when 9789 breeding pairs were reported. For some time, the stronghold breeding population of bald eagles in the lower 48 states was in Florida, where over a thousand pairs have held on while populations in other states were significantly reduced by DDT use. Today, the Contiguous United States with the largest number of breeding pairs of eagles is Minnesota with an estimated 1,312 pairs, surpassing Floridas most recent count of 1,166 pairs. 23, or nearly half, of the 48 contiguous states now have at least 100 breeding pairs of bald eagles. In Washington State, there were only 105 occupied nests in 1980. That number increased by about 30 per year, so that by 2005 there were 840 occupied nests. 2005 was the last year that the Washington Department of Fish and Wildlife counted occupied nests. Further population increases in Washington may be limited by the availability of late winter food, particularly salmon.
Output: Which area had the second highest numbers of bald eagles in 1992?
Yuval Zellner (Hebrew: , born 2 March 1978) is an Israeli politician.
Output: What was the date of birth of Yuval Zellner?
The Nimrud ivories are carved ivory plaques and figures dating from the 9th to the 7th centuries BC that were excavated from the Assyrian city of Nimrud (in modern Ninawa in Iraq) during the 19th and 20th centuries.
Output: What is the surface of Nimrud ivories made of?
Many people have problems with their vision, or ability to see. Often, the problem is due to the shape of the eyes and how they focus light. Two of the most common vision problems are nearsightedness and farsightedness, which you can read about below. You may even have one of these vision problems yourself. Usually, the problems can be corrected with contact lenses or lenses in eyeglasses. In many people, they can also be corrected with laser surgery, which reshapes the outer layer of the eye. Click image to the left or use the URL below. URL: Nearsightedness, or myopia, is the condition in which nearby objects are seen clearly, but distant objects appear blurry. The Figure 1.1 shows how it occurs. The eyeball is longer (from front to back) than normal. This causes images to be focused in front of the retina instead of on the retina. Myopia can be corrected with concave lenses. The lenses focus images farther back in the eye, so they fall on the retina instead of in front of it. Q: Sometimes squinting the eyes can help someone see more clearly. Why do you think this works? A: Squinting may improve focus by slightly changing the shape of the eyes. When you squint, you tighten muscles around the eyes, putting pressure on the eyeballs. Farsightedness, or hyperopia, is the condition in which distant objects are seen clearly, but nearby objects appear blurry. It occurs when the eyeball is shorter than normal (see Figure 1.2). This causes images to be focused in a spot that would fall behind the retina (if light could pass through the retina). Hyperopia can be corrected with convex lenses. The lenses focus images farther forward in the eye, so they fall on the retina instead of behind it. Q: Joey has hyperopia. When is he more likely to need his glasses: when he reads a book or when he watches TV? A: With hyperopia, Joey is farsighted. He can probably see the TV more clearly than the words in a book because the TV is farther away. Therefore, he is more likely to need his glasses when he reads than when he watches TV.
Output: in hyperopia, the eyeball is
Miami trailed 10-0 with just over four minutes remaining, but touchdown passes from quarterback Ryan Tannehill to Jarvis Landry and DeVante Parker put the Dolphins up by four points with 36 seconds left on the clock. The Rams' rookie quarterback Jared Goff attempted a hail mary pass to try and give the Rams the win, but the pass was incomplete, resulting in a 14-10 win for the Dolphins. With the win, the Dolphins improved to 6-4. They also improved to 11-2 all-time against the Rams.
Output: Who is the Rams quarterback?
Carbon is a very common ingredient of matter because it can combine with itself and with many other elements. It can form a great diversity of compounds, ranging in size from just a few atoms to thousands of atoms. There are millions of known carbon compounds, and carbon is the only element that can form so many different compounds. Carbon is a nonmetal in group 14 of the periodic table. Like other group 14 elements, carbon has four valence electrons. Valence electrons are the electrons in the outer energy level of an atom that are involved in chemical bonds. The valence electrons of carbon are shown in the electron dot diagram in the Figure 1.1. Q: How many more electrons does carbon need to have a full outer energy level? A: Carbon needs four more valence electrons, or a total of eight valence electrons, to fill its outer energy level. A full outer energy level is the most stable arrangement of electrons. Q: How can carbon achieve a full outer energy level? A: Carbon can form four covalent bonds. Covalent bonds are chemical bonds that form between nonmetals. In a covalent bond, two atoms share a pair of electrons. By forming four covalent bonds, carbon shares four pairs of electrons, thus filling its outer energy level and achieving stability. A carbon atom can form covalent bonds with other carbon atoms or with the atoms of other elements. Carbon often forms bonds with hydrogen. Compounds that contain only carbon and hydrogen are called hydrocarbons. Methane (CH4 ), which is modeled in the Figure 1.2, is an example of a hydrocarbon. In methane, a single carbon atom forms covalent bonds with four hydrogen atoms. The diagram on the left in the Figure 1.2 shows all the shared valence electrons. The diagram on the right in the Figure 1.2, called a structural formula, represents each pair of shared electrons with a dash (-). Methane (CH4 ) Carbon can form single, double, or even triple bonds with other carbon atoms. In a single bond, two carbon atoms share one pair of electrons. In a double bond, they share two pairs of electrons, and in a triple bond they share three pairs of electrons. Examples of compounds with these types of bonds are represented by the structural formulas in the Figure 1.3. Q: How many bonds do the carbon atoms share in each of these compounds? A: In ethane, the two carbon atoms share a single bond. In ethene they share a double bond, and in ethyne they share a triple bond.
Output: carbon forms triple bonds with other carbon atoms in the compound named
''She Shook Me Cold'' is a song written by David Bowie in 1970 for the album The Man Who Sold the World.
Output: Who performed She Shook Me Cold?
Niclas Muller (born in Langenau, near Ulm, Germany, on 15 November 1809; died in New York City, 14 August 1875) was a German-American poet.
Output: In what city did Niclas Müller die?
Lene Alexandra ien (born October 29, 1981 in Trgstad, Norway) is a Norwegian singer, television personality and model.
Output: What is the name of the city Lene Alexandra was born in?
Can storms in Africa cause asthma in the Caribbean ? Islanders point to the desert insects that land on beaches after a 5,000-kilometer flight across the Atlantic. If they can use winds to get from one continent to another, so can clouds of dust that carry disease. Scientists think that as Africa becomes drier, dust from expanding deserts is being blown away into Caribbean islands. A study in Barbados shows that asthma has increased 17 times since Africa's drought began in 1973. Other forms of life are suffering, too. Among them are the Caribbean's famous coral reefs( ), which began dying in large numbers in the 1900s. Eugene Shinn of the U.S. Geiological Sudrvey(USGS) in Florida went to the virgin Islands to study the reefs. The tests he and his colleagues carried out showed that the coral was dying of disease caused by Africa microbes from across the ocean. William Sprigg of the University of Arizona is studying the problem as part of a major UN project. He says that dust is causing problems in the U.S., too. "We are just beginning to collect the evidence of airborne dust influences on human health," he toldThe Washington Post.
Output: Where does the dust talked about in this passage come from?
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), may be the most common dominantly inherited ataxia in the world. Here I will review historical, clinical, neuropathological, genetic, and pathogenic features of MJD, and finish with a brief discussion of present, and possible future, treatment for this currently incurable disorder. Like many other dominantly inherited ataxias, MJD/SCA3 shows remarkable clinical heterogeneity, reflecting the underlying genetic defect: an unstable CAG trinucleotide repeat that varies in size among affected persons. This pathogenic repeat in MJD/SCA3 encodes an expanded tract of the amino acid glutamine in the disease protein, which is known as ataxin-3. MJD/SCA3 is one of nine identified polyglutamine neurodegenerative diseases which share features of pathogenesis centered on protein misfolding and accumulation. The specific properties of MJD/SCA3 and its disease protein are discussed in light of what is known about the entire class of polyglutamine diseases.
Output: Which is the protein implicated in Spinocerebellar ataxia type 3?
Salusa Secundus is a fictional planet appearing in Frank Herbert's Dune universe.
Output: What fictional universe is Salusa Secundus a part of?
The genetic disorders xeroderma pigmentosum (XP) and Cockayne syndrome (CS) exhibit deficiencies in the repair of UV-induced DNA damage. CS fibroblasts retain proficient nucleotide excision repair (NER) of inactive (or bulk) DNA, but are deficient in the transcription-coupled repair (TCR) of active genes. In contrast, XP complementation group C (XP-C) fibroblasts retain proficient TCR, but are deficient in bulk DNA repair. The remaining NER-deficient XP groups exhibit deficiencies in both repair pathways. Ad5HCMVsp1lacZ is a recombinant adenovirus vector that is unable to replicate in human fibroblasts, but can efficiently infect and express the beta-galactosidase reporter gene in these cells. We have examined the host cell reactivation (HCR) of beta-galactosidase activity for UV-irradiated Ad5HCMVsp1lacZ in non-irradiated and UV-irradiated normal, XP-B, XP-C, XP-D, XP-F, XP-G, CS-A and CS-B fibroblasts. HCR of beta-galactosidase activity for UV-irradiated Ad5HCMVsp1lacZ was reduced in non-irradiated cells from each of the repair-deficient groups examined (including XP-C) relative to that in non-irradiated normal cells. Prior irradiation of cells with low UV fluences resulted in an enhancement of HCR for normal and XP-C strains, but not for the remaining XP and CS strains. HCR of the UV-damaged reporter gene in UV-irradiated XP and CS strains was similar to measurements of TCR reported previously for these cells. These results suggest that UV treatment results in an induced repair of UV-damaged DNA in the transcribed strand of an active gene in XP-C and normal cells through an enhancement of TCR or a mechanism which involves the TCR pathway.
Output: Which gene strand is targeted by transcription-coupled repair (TCR)?
Mitochondrial (mt) genomes from diverse phylogenetic groups vary considerably in size, structure and organization. The genus Plasmodium, the causative agent of malaria, has the smallest mt genome in the form of a tandemly repeated, linear element of 6 kb. The Plasmodium mt genome encodes only three protein genes (cox1, cox3 and cob) and large- and small-subunit ribosomal RNA (rRNA) genes, which are highly fragmented with 19 identified rRNA pieces. The complete mt genome sequences of 21 Plasmodium species have been published but a thorough investigation of the arrangement of rRNA gene fragments has been undertaken for only Plasmodium falciparum, the human malaria parasite. In this study, we determined the arrangement of mt rRNA gene fragments in 23 Plasmodium species, including two newly determined mt genome sequences from P. gallinaceum and P. vinckei vinckei, as well as Leucocytozoon caulleryi, an outgroup of Plasmodium. Comparative analysis reveals complete conservation of the arrangement of rRNA gene fragments in the mt genomes of all the 23 Plasmodium species and L. caulleryi. Surveys for a new rRNA gene fragment using hidden Markov models enriched with recent mt genome sequences led us to suggest the mtR-26 sequence as a novel candidate LSU rRNA fragment in the mt genomes of the 24 species. Additionally, we found 22-25 bp-inverted repeat sequences, which may be involved in the generation of lineage-specific mt genome arrangements after divergence from a common ancestor of the genera Eimeria and Plasmodium/Leucocytozoon.
Output: Which is the causative agent of malaria?
alpha-Synuclein is a presynaptic protein recently identified as a specific component of Lewy bodies (LB) and Lewy neurites. The aim of this study was to assess the morphology and distribution of alpha-synuclein immunoreactivity in cases of dementia with LB (DLB), and to compare alpha-synuclein with ubiquitin immunostaining. We examined substantia nigra, paralimbic regions (entorhinal cortex, cingulate gyrus, insula and hippocampus), and neocortex (frontal and occipital association cortices) with double alpha-synuclein and ubiquitin immunostaining in 25 cases meeting neuropathological criteria for DLB. alpha-Synuclein immunostaining was more specific than ubiquitin immunostaining in that it differentiated LB from globose tangles. It was also slightly more sensitive, staining 4-5% more intracytoplasmic structures, especially diffuse alpha-synuclein deposits that were ubiquitin negative. In addition to LB, alpha-synuclein staining showed filiform and globose neurites in the substantia nigra, CA2-3 regions of the hippocampus, and entorhinal cortex. A spectrum of alpha-synuclein staining was seen in substantia nigra: from diffuse "cloud-like" inclusions to aggregated intracytoplasmic inclusions with variable ubiquitin staining to classic LB. We hypothesize that these represent different stages in LB formation.
Output: Against which protein is the antibody used for immonostaining of Lewy bodies raised?
Many of us believe that a person's mind becomes less active as he grows older.But this is not true,according to Dr.Lissy F.Jarvik,professor of psychiatry at the University of California,Los Angeles,and a board member of the New Center for Aging at the Veterans Hospital.She has studied the mental functioning of aging persons for several years.For example,one of her studies concerns 136 pairs of twins, who were first examined when they were already 60 years old.As Dr.Jarvik continued the study of the twins into their 70s and 80s,their minds did not generally decline as was expected. However,there was some decline in their psycho-motor speed. This means that it took them longer to accomplish mental tasks than it used to.But when speed was not a factor,they lost very little intellectual ability over the years.In general,Dr.Jarvik's studies have shown that there is no decline in knowledge or reasoning ability.This is true not only into the 30s and 40s,but into the 60s and 70s as well. As for learning new things,and ability to remember,studies by Dr.Jarvik and others show that the old are equal to the young.It is true that older people themselves often complain that their memory is not as good as it once was.However,much of what we call"loss of memory"is not that at a11. In the cases where the older person's mind really seems to decline,it is not necessarilv a sign of a decay due to becoming old or"senility".Often it is simply a sign of a depressed emotional state.This depression usually can be got rid of by counseling with a psychologist,or medicine which fights depression. In American society,when an older person loses something,we tend to call him or her"senile".But notice that when a younger person loses something,he does not blame it on senility or loss of memory.He finds some other excuse!
Output: A long-term study of 136 pairs of twins showed that the only factor that declined over the years was  .
The Jinfeng Gold Mine (Chinese: ) is an combined open pit and underground gold mining operation in the Guizhou province, China.
Output: The product of Jinfeng Gold Mine is what?
In Russia, an intradermal Diaskintest® drug has been designed, which is a recombinant tuberculosis allergen based on M. tuberculosis-- specific proteins: ESAT-6 and CFP-10 produced by a genetically modified Escherichia coli culture. Diaskintest® test and Mantoux test with 2TE PPD-L were concurrently carried out in 300 children and adolescents with tuberculosis and followed up in risk groups at a tuberculosis dispensary to determine the sensitivity of the new skin test in active tuberculosis infection. Diaskintest® showed a high sensitivity not only in active tuberculosis, but also in occult, the so-called latent, tuberculosis infection. This is suggested by the following evidence. The high percentage (83.8%) of positive responses to Diaskintest® is noted in children and adolescents with tuberculosis, receiving an intensive course of chemotherapy. Negative tests were observed only in minor forms at the resolution stage. In the children who had completed treatment, positive tests were seen in 78.3%, moreover in those with prior tuberculosis of intrathoracic lymph nodes; negative tests were observed not earlier than 18 months after start of treatment. The highest sensitivity of Diaskintest® was shown in children with early primary tuberculosis infection and through family contact with bacteria-excreting subjects (91.7%). These children may be judged with the highest assurance to have latent tuberculosis infection, the population of which is in an active state at the moment of the study. The children with early primary tuberculosis infection, but in no family contact with bacteria-excreting individuals, showed a lower percentage of positive responses to Diaskintest® both before (37.5%) and after (10%) treatment, which suggests that there must be a lower bacterial burden in the child. A high percentage of positive responses to Diaskintest® (76.2%) were found in subjects with hyperergic reactions to tuberculin. These were in only 16.7% in the group of patients receiving preventive therapy. In children and adolescents with a persistent positive Mantoux test (for more than 3 years), the response to Diaskintest® was negative in most cases since in early infection when mycobacteria propagated, the reaction to the drug was positive, but as 3 years pass the probability of the infection transition to the persistence stage is high--at that time the response to Diaskintest® becomes negative. Diaskintest® induces no delayed hypersensitivity associated with BCG vaccination, suggesting its high specificity. There were no positive reactions in patients with nonspecific lung diseases.
Output: The Mantoux test detects what latent infection/disease?