niryuu/sni-each-converted huggingface dataset:
Alpha-synuclein forms the major component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Here we show that alpha-synuclein is also the major component of the filamentous inclusions of multiple system atrophy which comprises several neurodegenerative diseases with a shared filamentous pathology in nerve cells and glial cells. These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha-synucleinopathies constitute a major class of human neurodegenerative disorder.
Output: Which is the primary protein component of Lewy bodies?
To evaluate the role of idarucizumab, a humanized monoclonal antibody fragment, as a specific reversal agent for the anticoagulant activity of dabigatran and to review the pharmacology, pharmacokinetic properties, efficacy, and safety of this agent. A literature search was conducted consisting of a PubMed database using the MeSH term idarucizumab and the key word dabigatran antidote. Studies evaluating the pharmacology, pharmacokinetics, safety, and efficacy of idarucizumab for the reversal of the anticoagulant activity of dabigatran were included. Idarucizumab represents a novel treatment option as it is the only humanized, monoclonal antibody fragment that specifically binds to dabigatran. Studies evaluating reversal of dabigatran-induced anticoagulation have demonstrated immediate, complete, and sustained effects with idarucizumab. Idarucizumab did not overcorrect thrombin generation. Additionally, evaluations have shown that dabigatran can be safely reinitiated 24 hours after the administration of idarucizumab. The United States Food and Drug Administration granted priority review for the biologic license application and accelerated approval for idarucizumab. Idarucizumab represents an encouraging development in the reversal of dabigatran. Its novel mechanism of action, pharmacokinetics, tolerability, and lack of thrombotic events contribute positively to its use in patients who experience bleeding or for those who require emergent surgery or procedures.
Output: Which drug can be reversed with idarucizumab?
The smallest front of the war was in Catalonia. In 1689 the Duke of Noailles had led French forces there aimed at bringing further pressure to bear on the Spanish by re-igniting a peasant rising against Charles II, which initially broke out in 1687. Exploiting the situation, Noailles captured Camprodon on 22 May, but a larger Spanish army under the Duke of Villahermosa forced him to withdraw back to Roussillon in August. The Catalan campaign settled down in 1690, but a new front in Piedmont-Savoy proved more eventful. A ferment of religious animosities and Savoyard hatred of the French produced a theatre characterised by massacres and atrocities: constant guerrilla attacks by the armed populace were met by draconian reprisals. In 1690 Saint-Ruth took most of the Victor Amadeus II's exposed Duchy of Savoy, routing the Savoyard army in the process until only the great fortress of Montmelian remained in ducal hands; while to the south in Piedmont, Nicolas Catinat led 12,000 men and soundly defeated Victor Amadeus at the Battle of Staffarda on 18 August. Catinat immediately took Saluzzo, followed by Savigliano, Fossano, and Susa, but lacking sufficient troops, and with sickness rife within his army, Catinat was obliged to withdraw back across the Alps for the winter.
Output: Where did Noailles go first, Camprodon or Roussillon?
An 11-day embryonic Swiss Webster/NIH mouse cDNA library was screened with a partial murine selenoprotein P cDNA probe and a murine selenoprotein-P-type cDNA clone of 2075 bp length was obtained. The clone contained a 5'-leader sequence of 132 bp length, the selenoprotein P coding frame, and 803 base pairs in the 3' untranslated region. Alignment and RNA folding studies revealed the presence of two well conserved selenocysteine inserting motifs in the 3' flanking region. The deduced polypeptide sequence comprises 380 residues including ten selenocysteines. Identical amino acid residues in homologous positions are 86%, 71%, and 64% when compared to the previously reported selenoprotein P sequences of rat, man, and cattle, respectively. The comparatively low similarity between the selenoprotein P sequences reported so far leaves open the question whether they belong to the same molecular clade.
Output: Which is the human selenoprotein that contains several Se-Cys residues?
Televisions were among the most talked about items at the 2013 International Consumer Electronics Show last week in Las Vegas, Nevada. Some employed the most advanced technology ever. Some of the TVs used a new technology called Organic Light Emitting Diodes, or OLED. They were thinner, lighter, offered better color1 and were brighter than traditional LEDs. Smart TVs this year were smarter. Many offered technology that let users have a more personalized experience. One such TV from the electronics company TCL uses sensors and voice recognition to determine who is watching. It then offers programming based on the specific user. Another TV from Panasonic offers a similar personalized user experience. In addition to television technology, size also played a major part in CES 2013. Televisions varied in size from big to bigger, with at least two companies -- Samsung and HiSense -- exhibiting TVs measuring 110 inches. The yearly Consumer Electronics Show is the biggest technology trade show in North America and one of the biggest in the world. Gary Shapiro is president and CEO of the Consumer Electronics Association, the group that organizes CES. He gave one of the keynote speeches on opening day. "Now you know that CES is more than a trade show. It's a gathering of the brightest minds and the top leaders from many industries and those seeking a glimpse into the future." That glimpse into the future included a look at digital health and fitness devices, which were also big at CES 2013. There were devices that track your activity and others that measure blood pressure, heart rate and weight. There was even a fork that tells you when you are eating too fast. Cars, smart-phones, tablet computers and PCs also made news. And a 27-inch table computer drew quite a bit of attention. CEA President Gary Shapiro says there was much to see but not nearly enough time to see it all. "You cannot see the show in the four days that you have. We have over 3200 different industries showing over 20,000 new products. It's ly incredible."
Output: At the 2013 CES, which item drew the most attention?
One success story in reducing pollutants that harm the atmosphere concerns ozone-destroying chemicals. In 1973, scientists calculated that CFCs could reach the stratosphere and break apart. This would release chlorine atoms, which would then destroy ozone. Based only on their calculations, the United States and most Scandinavian countries banned CFCs in spray cans in 1978. More confirmation that CFCs break down ozone was needed before more was done to reduce production of ozone- destroying chemicals. In 1985, members of the British Antarctic Survey reported that a 50% reduction in the ozone layer had been found over Antarctica in the previous three springs. Two years after the British Antarctic Survey report, the "Montreal Protocol on Substances that Deplete the Ozone Layer" was ratified by nations all over the world. The Montreal Protocol controls the production and consumption of 96 chemicals that damage the ozone layer (Figure 1.1). Hazardous substances are phased out first by developed nations and one decade later by developing nations. More hazardous substances are phased out more quickly. CFCs have been mostly phased out since 1995, although were used in developing nations until 2010. Some of the less hazardous substances will not be phased out until 2030. The Protocol also requires that wealthier nations donate money to develop technologies that will replace these chemicals. Ozone levels over North America decreased between 1974 and 2009. Models of the future predict what ozone levels would have been if CFCs were not being phased out. Warmer colors indicate more ozone. Since CFCs take many years to reach the stratosphere and can survive there a long time before they break down, the ozone hole will probably continue to grow for some time before it begins to shrink. The ozone layer will reach the same levels it had before 1980 around 2068 and 1950 levels in one or two centuries.
Output: the united states and most scandinavian countries banned ________ that were found to contain cfcs.
While Clostridium difficile epidemiology is well documented in many European countries, data are largely missing for South Eastern European region. Here we report the PCR ribotype distribution of 249 C.difficile isolates received for typing from six hospital settings from Croatia, Bosnia and Herzegovina, Republic of Macedonia and Serbia in time period from 2008 to 2015. Twenty-four PCR ribotypes were detected. The majority of strains from Bosnia and Herzegovina and Serbia belonged to PCR ribotype 027 (65.8%). Other three dominating PCR ribotypes were 176 (18 strains; Croatia), 001/072 (15 strains; all countries) and 014/020 (15 strains; all countries).
Output: Which main ribotype of Clostridium difficile is responsible of the recent outbreak?
This article needs an improved plot summary. (November 2015) Sidhu (Akshay Kumar) is a lowly vegetable cutter at a roadside food stall in the Chandni Chowk section of Delhi, who consults astrologers, tarot card readers, and fake fakirs despite his foster father Dada's (Mithun Chakraborty) exhortations. When two strangers from China claim him as a reincarnation of war hero 'Liu Shen' and take him to China, Sidhu, encouraged by trickster Chopstick (Ranvir Shorey), believes he will be feted as a hero, unaware of his own recruitment to assassinate the smuggler Hojo (Gordon Liu). Sidhu travels to China with Chopstick. Along the way he meets Sakhi (Deepika Padukone), the Indian-Chinese spokesmodel known as Ms. Tele Shoppers Media, or Ms. TSM, who also appears in China. Her twin sister Suzy, known as the femme fatale Meow Meow, works for Hojo, not knowing Hojo tried to kill her father, Inspector Chiang (Roger Yuan). Sidhu, through a series of accidents, initially eludes Hojo, but Hojo eventually exposes him as a fraud. Thereupon Hojo kills Dada, and Sidhu is beaten and urinated on by Hojo. Injured and disgraced Sidhu vows revenge. He thereafter encounters an amnesiac vagrant, whom he later identifies to Sakhi as Inspector Chiang. Chiang later recovers his memory and trains Sidhu in kung fu. When Hojo again meets with Sidhu, Suzy injures Chiang; but upon seeing Sakhi, betrays Hojo. Sidhu fights Hojo in single combat, eventually using a modified vegetable-cutting technique to overwhelm him. In the aftermath, Sidhu opens a vegetable stall in China, but is recruited to fight for some African pygmies. The film thereupon concludes with the announcement "To be Continued Chandni Chowk to Africa".
Output: What is the conman's name?
Alejandro Adem is a professor in the Department of Mathematics at the University of British Columbia since 2005 and the holder of a Canada Research Chair at UBC.
Output: What is Alejandro Adem's place of employment?
The Exquisite Thief is a 1919 American silent drama film directed by Tod Browning.
Output: Who was the director for The Exquisite Thief?
Tony Scott died on 19 August 2012, committing suicide by jumping off the Vincent Thomas Bridge in San Pedro, California.
Output: What was the cause of death of Tony Scott?
The aim of this study was to elucidate the role of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) 2 in pathologic wound healing after glaucoma surgery. We therefore investigated the expression of LOX and LOXL2 and evaluated the therapeutic potential of anti-LOX (GS-639556, formerly M64) and anti-LOXL2 (GS-607601, formerly AB0023) antibodies in a rabbit model of glaucoma trabeculectomy. Ocular expression of LOX and LOXL2 was investigated by immunohistologic staining at different time points after trabeculectomy. Treatment with GS-639556 or GS-607601 was initiated in rabbits immediately after trabeculectomy by giving both intracameral and subconjunctival injections. Thereafter, the antibodies were given twice a week subconjunctivally until day 30 after surgery (day of euthanization). Treatment outcome was studied by clinical investigation of the bleb and by immunohistochemical analysis of angiogenesis, inflammation, and collagen deposition. LOX and LOXL2 were both upregulated in Tenon's capsule and the conjunctiva after glaucoma surgery. Repeated administration of LOX- or LOXL2-targeting monoclonal antibodies increased bleb area and bleb survival. Analyses of immunohistologic stainings showed that both antibodies significantly decreased fibrosis, whereas the anti-LOXL2 antibody also significantly reduced blood vessel density and inflammation. Targeting LOXL2 with an inhibitory monoclonal antibody (GS-607601) reduced pathologic angiogenesis, inflammation, and fibrosis. These results suggest that LOXL2 could be an appealing target for treatment of scar formation after glaucoma surgery, and point to the potential therapeutic benefits of simtuzumab, a humanized monoclonal antibody derived from GS-607601.
Output: What is the drug target for Simtuzumab?
Viroids are small, circular, single-stranded RNA molecules that cause several infectious plant diseases. Viroids do not encode any pathogen-specific peptides but nonetheless, the subviral pathogens replicate autonomously and spread in the plant by recruiting host proteins via functional motifs encoded in their RNA genome. During the past couple of years, considerable progress has been made towards comprehending how viroids interact with their hosts. Here, we summarize recent findings on the structure-function relationships of viroids, their strategies and mechanisms of replication and trafficking, and the identification and characterization of interacting host proteins. We also describe the impact of the RNA silencing machinery of plants on viroid RNAs and how this has started to influence our models of viroid replication and pathogenicity.
Output: Which are the smallest known subviral pathogens of plants?
Elizabeth Potts (nee Atherton; December 21, 1846 -- June 20, 1890) was convicted of murder in 1889 and hanged the following year, the only woman ever to be legally executed in the U.S. state of Nevada.
Output: Which crime led to the conviction of Elizabeth Potts?
The Broadgate Tower was designed by Skidmore, Owings & Merrill and developed by British Land.
Output: Who was the architect involved with Broadgate Tower?
Corynebacterium minutissimum is the bacteria that leads to cutaneous eruptions of erythrasma and is the most common cause of interdigital foot infections. It is found mostly in occluded intertriginous areas such as the axillae, inframammary areas, interspaces of the toes, intergluteal and crural folds, and is more common in individuals with diabetes mellitus than other clinical patients. This organism can be isolated from a cutaneous site along with a concurrent dermatophyte or Candida albicans infection. The differential diagnosis of erythrasma includes psoriasis, dermatophytosis, candidiasis and intertrigo, and methods for differentiating include Wood's light examination and bacterial and mycological cultures. Erythromycin 250mg four times daily for 14 days is the treatment of choice and other antibacterials include tetracycline and chloramphenicol; however, the use of chloramphenicol is limited by bone marrow suppression potentially leading to neutropenia, agranulocytosis and aplastic anaemia. Further studies are needed but clarithromycin may be an additional drug for use in the future. Where there is therapeutic failure or intertriginous involvement, topical solutions such as clindamycin, Whitfield's ointment, sodium fusidate ointment and antibacterial soaps may be required for both treatment and prophylaxis. Limited studies on the efficacy of these medications exist, however, systemic erythromycin demonstrates cure rates as high as 100%. Compared with tetracyclines, systemic erythromycin has greater efficacy in patients with involvement of the axillae and groin, and similar efficacy for interdigital infections. Whitfield's ointment has equal efficacy to systemic erythromycin in the axillae and groin, but shows greater efficacy in the interdigital areas and is comparable with 2% sodium fusidate ointment for treatment of all areas. Adverse drug effects and potential drug interactions need to be considered. No cost-effectiveness data are available but there are limited data on cost-related treatment issues. A guideline is proposed for the detection, evaluation, treatment and prophylaxis of this cutaneous eruption.
Output: Which bacteria causes erythrasma?
Travis Graham (born 8 May 1993) is a South African football player who plays as a midfielder for Ajax Cape Town in the Premier Soccer League.
Output: Which is the position of Travis Graham?
When Serbia and Montenegro peacefully separated in 2006, the YUBA League ceased to exist and was re-branded as the Basketball League of Serbia a Serbia-only organization, with Montenegro forming its own federation.
Output: Which replaced the YUBA League?
It's eight o'clock and the time for Morning New Highlights . One person was killed and two were injured in a car accident just thirty minutes ago. Cause of the accident is not yet found out. A great fire swept through a storehouse next to the Fulton River early this morning, causing about $3,000,000 in damage. The fire which broke out at about 2:30 was finally put out at 5: 30. That was the Morning News Highlights, Dan Verne reporting.
Output: How many pieces of news are reported in the short passage?
The 2010 maternal mortality rate per 100,000 births for Guinea is 680. This is compared with 859.9 in 2008 and 964.7 in 1990. The under 5 mortality rate, per 1,000 births is 146 and the neonatal mortality as a percentage of under 5s mortality is 29. In Guinea the number of midwives per 1,000 live births is 1 and the lifetime risk of death for pregnant women is 1 in 26. Guinea has the second highest prevalence of female genital mutilation in the world.
Output: Is the maternal mortality rate in Guinea higher in 2010 or 2008?
With transform plate boundaries, the two slabs of lithosphere are sliding past each other in opposite directions. The boundary between the two plates is a transform fault. Transform faults on continents separate two massive plates of lithosphere. As they slide past each other, they may have massive earthquakes. The San Andreas Fault in California is perhaps the worlds most famous transform fault. Land on the west side is moving northward relative to land on the east side. This means that Los Angeles is moving northward relative to Palm Springs. The San Andreas Fault is famous because it is the site of many earthquakes, large and small. (Figure At the San Andreas Fault in California, the Pacific Plate is sliding northeast relative to the North American plate, which is moving southwest. At the northern end of the picture, the transform boundary turns into a subduction zone. Transform plate boundaries are also found in the oceans. They divide mid-ocean ridges into segments. In the diagram of western North America, the mid-ocean ridge up at the top, labeled the Juan de Fuca Ridge, is broken apart by a transform fault in the oceans. A careful look will show that different plates are found on each side of the ridge: the Juan de Fuca plate on the east side and the Pacific Plate on the west side.
Output: when two slabs of lithosphere slide past each other, the result is
In late 1911, she worked as a secretary for Sun Yat-sen, a job later succeeded by her sister, Soong Ching-ling, who later became Madame Sun Yat-sen. Soong Ai-ling met her future husband, Kung Hsiang Hsi, in 1913, and married the following year in Yokohama.
Output: Which woman was the sister of Soong Ai-ling?
at Invesco Field at Mile High, Denver, Colorado TV Time: ESPN 8:30pm eastern The Ravens suffered their first loss of the season as they were beaten 13-3 by the Denver Broncos. In a defensive struggle most of the game, Steve McNair was intercepted three times and Jamal Lewis was held to 43 yards rushing. The Ravens got on the board first when Matt Stover kicked a 24-yard field goal, following a fumble by Broncos RB Tatum Bell. The Broncos responded with a 43-yard field goal of their own by Jason Elam. The Ravens drove deep into Broncos territory late at the end of the first half, but that drive was thwarted as Steve McNair was intercepted by Champ Bailey in the end zone on a pass intended for Clarence Moore. The third quarter saw no points scored by either team as the defensive struggle continued. The Broncos controlled the clock in the second half with the running game led by Tatum Bell, who atoned for his fumble in the first quarter, by bouncing back with 92 yards rushing. Ravens QB McNair was intercepted again by Darrent Williams, which led to a Jake Plummer to Rod Smith touchdown pass. McNair was intercepted a third time, ending the Ravens' final drive, this time by Domonique Foxworth. With their first loss, the Ravens dropped to 4-1.
Output: Who kicked the longest field goal of the game?
Hoping to break their current losing streak the Cardinals flew to Arrowhead Stadium for an interconference duel with the Chiefs. The Cardinals scored with kicker Jay Feely hitting a 36-yard field goal, but they fell behind with QB Matt Cassel completing a 1-yard TD pass to WR Dwayne Bowe. This was followed by RB Thomas Jones getting a 1 and a 3-yard TD run. The Cardinals responded with Feely making a 29-yard field goal, but they struggled further with kicker Ryan Succop getting a 23-yard field goal, followed by Cassel throwing a 38-yard TD pass to Bowe. The Cardinals cut the lead with QB Derek Anderson completing a 3-yard TD pass to WR Larry Fitzgerald.
Output: What was the second shortest TD run
Specific reversal agents for non-vitamin K antagonist oral anticoagulants are lacking. Idarucizumab, an antibody fragment, was developed to reverse the anticoagulant effects of dabigatran. We undertook this prospective cohort study to determine the safety of 5 g of intravenous idarucizumab and its capacity to reverse the anticoagulant effects of dabigatran in patients who had serious bleeding (group A) or required an urgent procedure (group B). The primary end point was the maximum percentage reversal of the anticoagulant effect of dabigatran within 4 hours after the administration of idarucizumab, on the basis of the determination at a central laboratory of the dilute thrombin time or ecarin clotting time. A key secondary end point was the restoration of hemostasis. This interim analysis included 90 patients who received idarucizumab (51 patients in group A and 39 in group B). Among 68 patients with an elevated dilute thrombin time and 81 with an elevated ecarin clotting time at baseline, the median maximum percentage reversal was 100% (95% confidence interval, 100 to 100). Idarucizumab normalized the test results in 88 to 98% of the patients, an effect that was evident within minutes. Concentrations of unbound dabigatran remained below 20 ng per milliliter at 24 hours in 79% of the patients. Among 35 patients in group A who could be assessed, hemostasis, as determined by local investigators, was restored at a median of 11.4 hours. Among 36 patients in group B who underwent a procedure, normal intraoperative hemostasis was reported in 33, and mildly or moderately abnormal hemostasis was reported in 2 patients and 1 patient, respectively. One thrombotic event occurred within 72 hours after idarucizumab administration in a patient in whom anticoagulants had not been reinitiated. Idarucizumab completely reversed the anticoagulant effect of dabigatran within minutes. (Funded by Boehringer Ingelheim; RE-VERSE AD ClinicalTrials.gov number, NCT02104947.).
Output: Idarucizumab is an antidote of which drug?
Peregrine Bertie, 13th Baron Willoughby de Eresby (12 October 1555 -- 25 June 1601) was the son of Catherine Willoughby, 12th Baroness Willoughby de Eresby, and Richard Bertie.
Output: Which lady gave birth to Peregrine Bertie, 13th Baron Willoughby de Eresby?
Nicholas Barre, O.M. (21 October 1621 -- 31 May 1686), was a French Minim friar and Catholic priest, who founded the Sisters of the Infant Jesus.
Output: What group was Nicholas Barré a member of?
Playing again without Calvin Johnson, the Lions fell behind the visiting New Orleans Saints by two scores on two separate occasions, before mounting a dramatic comeback in the final minutes of the game. New Orleans had three of the first four scoring plays of the game. Drew Brees hit Austin Johnson with a 14-yard TD pass, Shayne Graham made good on a 27-yard field goal, and Kenny Stills caught a 46-yard TD pass from Brees. Meanwhile, the Lions could only muster a 21-yard field goal by Matt Prater, falling behind 17-3. Detroit closed the gap to 17-10 in the third quarter after a 1-yard TD run by Joique Bell. Two more Shayne Graham field goals, however, gave the Saints a seemingly comfortable 23-10 lead with 5:24 to play in the game. With under four minutes to play, Matthew Stafford connected with Golden Tate on a 73-yard catch-and-run, making the score 23-17. On the Saints' next possession, Glover Quin picked off a third-and-ten Drew Brees pass, returning it to the New Orleans 14-yard line. At the 1:48 mark, Corey Fuller made a leaping catch of a 5-yard TD pass from Stafford for the winning touchdown in a 24-23 game. The Lions' defense held off the Saints in four downs, then the offense ran out the clock for the win.
Output: Who threw the second longest touchdown pass?
Rear Admiral James Edward Jouett (7 February 1826 -- 30 September 1902), known as ''Fighting Jim Jouett of the American Navy'', was an officer in the United States Navy during the Mexican-American War and the American Civil War.
Output: What conflict involved James Edward Jouett?
In Greek mythology, Dynamene (Ancient Greek: ) was a Nereid or sea-nymph, one of the 50 daughters of Nereus and Doris.
Output: Which lady gave birth to Dynamene?
Huntley Gordon died in Van Nuys, California and was interred in the Forest Lawn Memorial Park Cemetery in Glendale, California.
Output: What  is the place of burial for Huntley Gordon?
In 2009, 78.5% of Dallas (city) commuters drive to work alone. The 2009 modal share for Dallas (city) commuters are 10.7% for carpooling, 3.9% for transit, 1.9% for walking, and .1% for cycling. In 2015, the American Community Survey estimated modal shares for Dallas (city) commuters of 75.4% for driving alone, 12.8% for carpooling, 3.5% for riding transit, 1.9% for walking, and .2% for cycling. The city of Dallas has a higher than average percentage of households without a car. In 2015, 10.2 percent of Dallas households lacked a car, and decreased to 9.1 percent in 2016. The national average was 8.7 percent in 2016. Dallas averaged 1.59 cars per household in 2016, compared to a national average of 1.8.
Output: Which group of commuters in 2009 was the largest in Dallas, carpooling or transit?
The Steelers stayed home for a 3-game home stand and for a Sunday Night duel against the Ravens. The Ravens scored first when Joe Flacco hooked up with Torrey Smith 35-yard TD pass to take a 7-0 lead for the only score of the first quarter. In the 2nd quarter, the Steelers managed to tie the game up when Ben Roethlisberger found Le'Veon Bell on a 5-yard TD pass for a 7-7 game. They eventually took the lead when Roethlisberger found Martavis Bryant on a 19-yard TD pass to make it a 14-7 game. The Ravens came within 4 as Justin Tucker kicked a 46-yard field goal to make it 14-10 game. However, the Steelers would manage to go ahead by 12 before halftime when Roethlisberger found Markus Wheaton on a 47-yard TD pass followed by a successful 2-point conversion for a 22-10 lead at halftime. After a scoreless 3rd quarter, the Steelers came out strong and went back to work in the 4th when Roethlisberger found Antonio Brown on a 54-yard TD pass making the score 29-10. The Ravens responded with a big play as Jacoby Jones ran a 108-yard kickoff return for a TD to make it a 29-17 game. Roethlisberger found Bryant again on an 18-yard TD pass to make the score 36-17. This was followed by the Ravens trying their hand at coming back when Flacco found Crockett Gillmore on a 1-yard TD pass (with a failed 2-point conversion) for a 36-23 score. But the Steelers were able to seal the game when Roethlisberger found Matt Spaeth on a 33-yard TD pass for a final score of 43-23. A week after passing for a franchise-record six touchdowns against Indianapolis, Roethlisberger duplicated the feat to lead Pittsburgh to its third consecutive win. The 12 touchdown passes over the last two games broke the NFL record of 11 set by Tom Flores for Oakland in the AFL in 1963 and matched by New England's Tom Brady in 2007.
Output: Did the Steelers score fewer points in the first quarter or the 2nd quarter?
So that people in developed nations maintain a good lifestyle and people in developing nations have the ability to improve their lifestyles, natural resources must be conserved and protected (Figure 1.1). People are researching ways to find renewable alternatives to non-renewable resources. Here is a checklist of ways to conserve resources: Buy less stuff (use items as long as you can, and ask yourself if you really need something new). Reduce excess packaging (drink tap water instead of water from plastic bottles). Recycle materials such as metal cans, old cell phones, and plastic bottles. Purchase products made from recycled materials. Reduce pollution so that resources are maintained. Prevent soil erosion. Plant new trees to replace those that are cut down. Drive cars less, take public transportation, bicycle, or walk. Conserve energy at home (turn out lights when they are not needed). Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:
Output: which one of these can you not recycle
Rovering to Success is a book written by Robert Baden-Powell in 1922.
Output: Who is the illustrator of Rovering to Success?
On 7 July 1899, a part of the territory of Villiers-sur-Marne was detached and merged with a part of the territory of La Queue-en-Brie and a part of the territory of Chennevieres-sur-Marne to create the commune of Le Plessis-Trevise.
Output: Which replaced the Villiers-sur-Marne?
Fingolfin (IPA: (fiolfin)) is a fictional character in J. R. R. Tolkien's legendarium, appearing in The Silmarillion.
Output: With which fictional universe is the character Fingolfin associated?
After a tough loss at home to the Lions, the Eagles traveled down south to New Orleans to take on the Saints in the Mercedes-Benz Superdome. The Saints scored first with Patrick Robinson returning a Michael Vick interception 99 yards for a touchdown and a 7-0 lead for the only score of the game. The Eagles got on the board in the 2nd quarter as Alex Henery kicked a 22-yard field goal to cut the lead to 7-3 not long before Chris Ivory ran for a 22-yard touchdown to move the Saints ahead by 11 with a 14-3 lead and then they would score again with Drew Brees finding Marques Coltson on a 1-yard touchdown pass for a 21-3 halftime lead. The Eagles scored 10 unanswered points in the 3rd quarter with Vick hooking up with DeSean Jackson on a 77-yard touchdown pass for a score of 21-10 and then Henery kicked a 37-yard field goal for a score of 21-13. But the Saints scored one last time as Brees found Jimmy Graham on a 6-yard touchdown pass for a 28-13 lead which would be the final score of the game as neither team scored in the 4th quarter.
Output: What was the longest field goal of the game?
The Battle of Milne Bay (25 August -- 7 September 1942), also known as Operation RE by the Japanese, was a battle of the Pacific campaign of World War II. Elite Japanese naval troops, known as Kaigun Rikusentai (Special Naval Landing Forces), with tank support attacked the Allied airfields at Milne Bay that had been established on the eastern tip of New Guinea.
Output: On what date did Battle of Milne Bay end?
Webb Garwood (Van Heflin), a disgruntled cop, is called to investigate a voyeur by Susan Gilvray (Evelyn Keyes). Her husband works nights as an overnight radio personality. Webb falls in love with the young and attractive married woman. Obsessed, he woos her despite her initial reluctance and the two begin an adulterous affair. Webb finds out about an insurance policy on the husband's life. He dreams up a scheme in which a phantom "prowler" would be a good scapegoat if Susan's husband should happen to die mysteriously. After becoming a prowler himself, Webb "investigates" and then commits the murder, making it look like a tragic accident with he and the husband shooting at each other as each suspected the other of being the prowler. Webb's ruse fools a coroner's jury, thanks in part to both Susan and Webb testifying that they didn't know each other prior to her husband's death. Susan initially suspects Webb of foul play, but becomes convinced of his innocence and subsequently marries him. Shortly after the wedding, Susan informs Webb that she has been pregnant for four months. This is problematic because the date of the child's conception would prove the two had lied in their testimony to cover up their previous relationship, and would thus suggest that Webb's killing of Susan's husband had not been an accident. The two run away to a ghost town named Calico to have the baby without anyone back home knowing. Susan goes into premature labor and Webb finds a doctor, Dr. William James (Wheaton Chambers). Susan realizes that Webb intends to kill Dr. James to preserve their secret, so she warns the doctor who then escapes with the newborn. Susan tells Webb that she knows what he had planned to do and that she now realizes that he intentionally murdered her husband. Realizing the doctor will send the police after him, Webb drives away, leaving his wife in Calico alone. On the way out of town, he find the road blocked by his former partner on the police force who was coming to pay a visit. While attempting to get around his friend's car, Webb sees several police cars coming so he heads for the hills on foot. He refuses to stop and a sheriff's deputy shoots him dead.
Output: Who is killed first?
The Linth (pronounced (lnt) ''lint'') is a Swiss river that rises near the village of Linthal in the mountains of the canton of Glarus, and eventually flows into the Obersee section of Lake Zurich.
Output: What river does Linth turn into?
Sipho Sibiya Riopel (also known as Siphos Sibya) is a retired South African-Canadian soccer player who is an assistant coach with the Vancouver Whitecaps women's team.
Output: What was the name of Sipho Sibiya's team?
One of the biggest new bands in the UK is Arctic Monkeys.Their first two singles went straight to Number One in the charts and their first album "Whatever People Say I Am,That's what I'm No" has become a recordbreaking album.It's the fastest selling debut album in UK chart history. Arctic Monkeys are famous because of their great success.They achieved their success thanks to the Internet.Usually a new band signs to a record company and then it is through marketing that people buy their singles.The single sales then get the band into the charts and they become popular that way. However,Arctic Monkeys became wellknown in a slightly different way.Back in 2003 when the band first started,they handed out CDs at their performing concert.Certain fans liked the music so much that they put the music up on the Web.The general public had access to this music because it was on the Internet and,because people liked the music,the band's popularity increased.The band's popularity was starting to get noticed by major radio stations in the UK. Arctic Monkeys released their first single in October 2005.Before that,their music had only been available to download on the Internet.When they did finally release a single and an album,they both rose to the top of the charts. Music fans welcome the use of the Internet this way--Arctic Monkeys became popular simply because people liked their music when they heard it.There were no ads.As music downloads continue to increase in popularity,we can expect to see more and more bands make it big in this way.
Output: Why did Arctic Monkeys become popular?
Pulmonary hypertension (PH) is a progressive disease that is accompanied by a poor prognosis. Pulmonary vasoconstriction is facilitated through multiple pathways and results in increased pulmonary vascular pressure leading to cell proliferation, vascular remodeling, right ventricular hypertrophy/failure, and ultimately death. Until recently, just six medications were approved -all for one subclass of PH. On October 8, 2013, riociguat (Adempas®) became the first medication approved for multiple etiologies of PH. Preclinical studies have demonstrated safety and efficacy with significant clinical trials supporting its advancement into phase IV trials. Although long-term safety and efficacy and place in therapy remain to be established, riociguat presents as an exciting new option for the treatment of PH and potentially has additional indications in the near future.
Output: What is generic name of drug Adempas?
Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.
Output: Which enzyme is inhibited by a drug fostamatinib?
The Seahawks began their 2008 campaign on the road against the Buffalo Bills. In the first quarter, Seattle trailed early as Bills RB Marshawn Lynch got a 21-yard TD run. In the second quarter, the Seahawks continued to struggle as WR/PR Roscoe Parrish returned a punt 63 yards for a touchdown. Seattle responded with QB Matt Hasselbeck completing a 20-yard TD pass to WR Nate Burleson. Buffalo closed out the half with kicker Rian Lindell getting a 35-yard and a 38-yard field goal. In the third quarter, the Seahawks replied with kicker Olindo Mare nailing a 45-yard field goal. However, the Bills pulled a trick play on Seattle. Appearing to go for a 32-yard field goal, Buffalo's holder (punter Brian Moorman) instead threw a 19-yard TD pass to DE Ryan Denney. The Bills pulled away with QB Trent Edwards completing a 30-yard TD pass to TE Robert Royal.
Output: Who scored first?
Once acquired, Epstein-Barr virus (EBV), a latent virus, remains in the body for what appears to be the lifetime of the human host. Circumstantial data suggest EBV is involved in clinical disease including malignancies far more often than previously recognized. A serologic test for early antigen (EA) is more specific for diagnosing active EBV disease than the monospot or heterophile test. A case study of active Epstein-Barr infection is reported showing persistently elevated early antigen titers prior to and following malignant transformation.
Output: Which virus can be diagnosed with the monospot test?
Einar Billing born 6 October 1871 in Lund, died 17 December 1939 in Vasteras, was a Swedish hymnwriter and theologian.
Output: What city did Einar Billing live when he died?
Her daughter Ariadne was Empress consort of first Zeno and then Anastasius I. Verina was the maternal grandmother of Leo II.
Output: What was Verina's child's name?
The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.
Output: Which infection can be prevented with Dapivirine?
England has a longstanding problem with youngsters dropping out of training. Almost half of 17-year-olds in some parts of England have dropped out of fulltime education or training. The statistics show 49% in Thurrock and 44% in Salford have dropped out of school or job training. Across England,31%of 17-year-olds are not in education or training. The figures also reveal deep regional divides,with wealthier areas such as Richmon and Harrow recording18% of 17-year-olds out of official education. The statistics confirm England's poor international standing for staying-on rates in education. The Organization for Economic Cooperation and Development considers England's drop-out rates as among the worst among the industrialised countries. Regionally,the statistics show Yorkshire and the Humber have the highest rate of 17-year-olds not in full-time education or work-based training at 35%. Outer London has the highest staying-on rate,with l3%of 17-year-olds having dropped out of official learning. In the east of England this figure stands at 31%and at 29%in the South West. Edward Davey,Liberal Democrat Shadow Education Secretary,said the government "should be ashamed"that so many youngsters were dropping out of school. A spokesman for the Department for Education and Skills said the government had carried out a series of reforms,with aPS2.5 billion rise in funding for further education.
Output: Which part of England has the lowest rate of 17-year-olds dropping out of education?
Gene expression signatures can provide an unbiased view into the molecular changes underlying biologically and medically interesting phenotypes. We therefore initiated this study to identify signatures that would be of utility in studying rheumatoid arthritis (RA). We used microarray profiling of peripheral blood mononuclear cells (PBMCs) in 30 RA patients to assess the effect of different biologic agent (biologics) treatments and to quantify the degree of a type-I interferon (IFN) signature in these patients. A numeric score was derived for the quantification step and applied to patients with RA. To further characterize the IFN response in our cohort, we employed type-I IFN treatment of PBMCs in vitro and in reporter assays. Profiling identified a subset of RA patients with upregulation of type-I IFN-regulated transcripts, thereby corroborating previous reports showing RA to be heterogeneous for an IFN component. A comparison of individuals currently untreated with a biologic with those treated with infliximab, tocilizumab, or abatacept suggested that each biologic induces a specific gene signature in PBMCs. It is possible to observe signs of type-I IFN pathway activation in a subset of clinically active RA patients without C-reactive protein elevation. Furthermore, biologics-specific gene signatures in patients with RA indicate that looking for a biologic-specific response pattern may be a potential future tool for predicting individual patient response.
Output: Which is the most common gene signature in Rheumatoid Arthritis patients?
News @ 6 is the flagship evening newscast of People's Television Network in the Philippines, succeeding newscast Teledyaryo.
Output: What is the country News @ 6 is from?
Bright, Spacious Room Spacious, single furnished room in owner- occupied home is available now, for one and a half years. Ground floor flat. Five-minute walk to the town center and local bus services. Well-equipped shared kitchen, including washing machine. Shared shower& toilet. Large rooms, with high ceilings, a warm and pleasant home. Responsible for own food & cooking, washing, telephone, insurance, etc. No smoking or pets. Not suitable for children. WiFi available locally. Call Jenna on 85756624 if you are interested. One Bedroom Newly Refurbished Flat in Burnage A fantastic one-bedroom flat in the heart of Burnage is available for however long you want. The property has just been refurbished to a high standard. Situated above the pharmacy on Burnage Lane the property boasts a kitchen, large lounge, separate shower and toilet, and bedroom with in- built wardrobes. A must-see! Call Daniel on 70554323 at the weekend. Two Bedrooms Left in Four-bed House Share A great four- bedroom property in the heart of Fallowfield. Two Bedrooms left in a mixed student house. The property has a dining area, toilet, lounge and one bedroom on the ground floor, followed by three bedrooms on the first floor with an extra toilet. Very close to the main bus stop & local amenities : supermarket, Lloyds pharmacy and local launderette. Two minutes' walking distance to the centre of Fallowfield. The property is available from the 1 of July 2012 to 30 June 2013. Half rent for July/ Aug. We are a private landlord; so there are no agency fees! Jack welcomes you to call. Phone:22604322. Board and Lodgings Close to Boston, Lincolnshire We have a double room available on a board and lodgings basis from 1 of June, 2012 to 1 of May, 2013. Within a comfortable, peaceful farmhouse, set in lovely gardens and beautiful countryside. Share a bathroom with one other person only. Room has own TV with Freeview and access to wireless broadband,. Use of the garden and rest of the house. On the bus route to Boston and Horncastle. Free car parking space. All meals, bills, etc. included. Can cater for a variety of special dietary needs if required, Please call Alice at the weekend or after 7p.m. On workdays. Phone:42556755.
Output: Who should you contact if you want to rent long term?
Hill+Knowlton Strategies is a global public relations company, headquartered in New York City, United States, with 90 offices in 52 countries.
Output: Which industry is Hill+Knowlton Strategies associated with?
Cocodrilos de Caracas is a Venezuelan professional basketball club.
Output: What is Cocodrilos de Caracas's sport?