niryuu/sni-each-converted huggingface dataset:
The Paleozoic is the furthest back era of the Phanerozoic and it lasted the longest. But the Paleozoic was relatively recent, beginning only 570 million years ago. Compared with the long expanse of the Precambrian, the Phanerozoic is recent history. Much more geological evidence is available for scientists to study so the Phanerozoic is much better known. The Paleozoic begins and ends with a supercontinent. At the beginning of the Paleozoic, the supercontinent Rodinia began to split up. At the end, Pangaea came together. A mountain-building event is called an orogeny. Orogenies take place over tens or hundreds of millions of years. As continents smash into microcontinents and island arcs collided, mountains rise. Geologists find evidence for the orogenies that took place while Pangaea was forming in many locations. For example, Laurentia collided with the Taconic Island Arc during the Taconic Orogeny (Figure 1.1). The remnants of this mountain range make up the Taconic Mountains in New York. The Taconic Orogeny is an example of a collision between a continent and a volcanic island arc. Laurentia experienced other orogenies as it merged with the northern continents. The southern continents came together to form Gondwana. When Laurentia and Gondwana collided to create Pangaea, the Appalachians rose. Geologists think they may once have been higher than the Himalayas are now. Pangaea was the last supercontinent on Earth. Evidence for the existence of Pangaea was what Alfred Wegener used to create his continental drift hypothesis, which was described in the chapter Plate Tectonics. As the continents move and the land masses change shape, the shape of the oceans changes too. During the time of Pangaea, about 250 million years ago, most of Earths water was collected in a huge ocean called Panthalassa (Figure 1.2). Click image to the left or use the URL below. URL:
Output: this mountain range grew much higher when gondwana and laurentia collided to create pangaea.
That year the chocolate magnate Peter Ludwig agreed to endow 350 modern artworks--then valued at $45 million --and in return the City of Cologne committed itself to build a dedicated ''Museum Ludwig'' for works made after the year 1900.
Output: The Museum Ludwig was named for whom?
The film is a comedy of middle-class French life ' examining culture clashes, puncturing smugness, exposing fault lines, finding strength in romantic and familial relationships and discovering an underlying sadness that stops some way short of tragedy.'[3] The film is set in a small town in Provence during a rainy August. Following the death of her widowed mother Agathe Villanova comes from Paris to deal with the sale of the home where she and her younger sister Florence were brought up, and to announce her entry into politics. She is the author of a feminist best-seller and a divorced film-maker Michel wants to make a TV documentary about her. Michel is having an affair with Agathe's sister. His collaborator is a young Algerian hotel clerk Karim, whose elderly mother has worked for most of her life as a servant with the Villanova family. Agathe's prejudice is put under the microscope when she records a series of interviews with Karim. 'The characters weave around each other for a week or so, occasionally colliding...everyone comes to have a better knowledge of themselves..the dialogue rings true..the ensemble acting is perfect..The film compares favourably with the best of Eric Rohmer.' [4]
Output: What  is the name of the housekeeper who came to France with Villanova family when they left Algeria?
During the war, the Russian army organized the Crimean campaigns of 1687 and 1689 both which ended in Russian defeats. Despite these setbacks, Russia launched the Azov campaigns in 1695 and 1696, and after raising the siege in 1695 successfully occupied Azov in 1696.
Output: Which campaign was successful?
The Stadion pod Dubnom is an all-seater football stadium situated in Zilina, Slovakia, which is the home of MSK Zilina.
Output: What team uses Štadión pod Dubňom?
Transcription factors of the NFAT (nuclear factor of activated T cells) family are expressed in most immune system cells and in a range of other cell types. Signaling through NFAT is implicated in the regulation of transcription for the immune response and other processes, including differentiation and apoptosis. NFAT normally resides in the cytoplasm, and a key aspect of the NFAT activation pathway is the regulation of its nuclear import by the Ca(2+)/calmodulin-dependent phosphatase calcineurin. In a cell line stably expressing green fluorescent protein (GFP)-NFAT, this import can be triggered by elevation of intracellular calcium and visualized in live cells. Here we show that the inducible nuclear import of GFP-NFAT is efficiently blocked at early stages of herpes simplex virus (HSV) infection. This is a specific effect, since we observed abundant nuclear accumulation of a test viral protein and no impediment to general nuclear localization signal-dependent nuclear import and retention in infected cells. We show that virus binding at the cell surface is not itself sufficient to inhibit the signaling that induces NFAT nuclear translocation. Since the block occurs following infection in the presence of phosphonoacetic acid but not cycloheximide, we infer that the entry of the virion and early gene transcription are required but the effect is independent of DNA replication or late virus gene expression. A consequence of the block to GFP-NFAT import is a reduction in NFAT-dependent transcriptional activation from the interleukin-2 promoter in infected cells. This HSV-mediated repression of the NFAT pathway may constitute an immune evasion strategy or subversion of other NFAT-dependent cellular processes to promote viral replication.
Output: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
Ivan Francescato died suddenly of a heart attack at 3 a.m. at his home in Treviso.
Output: What was Ivan Francescato cause of death?
Rahmat-un-Nisa (1620 -- October/November 1691), better known by her title Nawab Bai, was the second wife of the Mughal Emperor Aurangzeb.
Output: What is Nawab Bai's spouse's name?
To be a good aquifer, the rock in the aquifer must have good: porosity: small spaces between grains permeability: connections between pores To reach an aquifer, surface water infiltrates downward into the ground through tiny spaces or pores in the rock. The water travels down through the permeable rock until it reaches a layer that does not have pores; this rock is impermeable (Figure 1.1). This impermeable rock layer forms the base of the aquifer. The upper surface where the groundwater reaches is the water table. Groundwater is found beneath the solid surface. Notice that the water table roughly mirrors the slope of the lands surface. A well penetrates the water table. For a groundwater aquifer to contain the same amount of water, the amount of recharge must equal the amount of discharge. What are the likely sources of recharge? What are the likely sources of discharge? What happens to the water table when there is a lot of rainfall? What happens when there is a drought? Although groundwater levels do not rise and fall as rapidly as at the surface, over time the water table will rise during wet periods and fall during droughts. In wet regions, streams are fed by groundwater; the surface of the stream is the top of the water table (Figure 1.2). In dry regions, water seeps down from the stream into the aquifer. These streams are often dry much of the year. Water leaves a groundwater reservoir in streams or springs. People take water from aquifers, too. Groundwater meets the surface in a stream (Figure 1.2) or a spring (Figure 1.3). A spring may be constant, or may only flow at certain times of year. Towns in many locations depend on water from springs. Springs can be an extremely important source of water in locations where surface water is scarce. A well is created by digging or drilling to reach groundwater. It is important for anyone who intends to dig a well to know how deep beneath the surface the water table is. When the water table is close to the surface, wells are a convenient method for extracting water. When the water table is far below the surface, specialized equipment must The top of the stream is the top of the water table. The stream feeds the aquifer. A spring in Croatia bubbles to the surface and feeds the river Cetina. be used to dig a well. Most wells use motorized pumps to bring water to the surface, but some still require people to use a bucket to draw water up (Figure 1.4). An old-fashioned well that uses a bucket drawn up by hand.
Output: the surface of a stream is
The Dolphins' eighth game was an AFC duel with the Ravens. The Dolphins trailed early after QB Joe Flacco completed a 32-yard TD pass to RB Willis McGahee. They replied with RB Ronnie Brown getting a 12-yard TD run. The Ravens got the lead back after kicker Billy Cundiff made a 26 and a 39-yard field goal. The Dolphins narrowed the lead with kicker Dan Carpenter nailing a 19-yard field goal. The Dolphins fell further behind after Flacco found WR Derrick Mason on a 12-yard TD pass. This was followed in the 4th quarter by Cundiff hitting a 20 and a 24-yard field goal.
Output: Who's touchdown pass was longer, Derrick Mason or Willis McGahee?
As a boy growing up in India, I had longed to travel abroad. I used to listen to the stories my father would tell me about his stay in Canada and tours to Europe in the 1970s, with great interest. My big moment finally came in the summer of 1998 when I was able to accompany my parents to Europe, where my father was to attend a meeting. We planned to travel to Belgium, Netherlands and West Germany. I have clear memories even today of going to Mumbai airport at night all excited about finally going abroad. I had heard several great things about Lufthansa till then but now I finally got to experience them first hand, during the flight to Frankfurt. We flew business class and even today I can remember the excellent service by the Lufthansa crew . The flight was really smooth and thoroughly enjoyable, even for someone like me, who is especially afraid of flying. After spending almost two weeks in Europe, we took the Lufthansa airport express from Dusseldorf to Frankfurt airport, for our return flight. What a journey that was! All along the Rhine , it was simply an unforgettable experience. I had a sombre feeling on the flight back to Mumbai as it marked the end of a wonderful vacation, but the Lufthansa crew members were able to change it into a most enjoyable experience yet again, with the quality of their service. Being the first airline to take me abroad, Lufthansa will always hold a special place in my heart. Even today,I continue to enjoy flights on Lufthansa and simply cannot dream of choosing any other airline. Flying, in general,for me,has always been a terrible and painful experience.Flying on Lufthansa,however, is something I always have and always will look forward to. ks5u
Output: Which country does the author live in now?
The Buccaneers faced former head coach Tony Dungy for the second time. The previous meeting between the two teams in 2003 saw the Colts erase a 21-point deficit in the final four minutes to win the game in overtime. Both teams entered the game with players sidelined by injuries. Marvin Harrison and Joseph Addai sat out for Indianapolis, while Carnell Williams and Luke Petitgout were placed on injured reserve for Tampa Bay. The Colts controlled the tempo of most of the game, with a time of possession of over 38 minutes and 400 yards of offense. The Buccaneers were held to only 177 total yards and only 17 yards rushing. The first three Buccaneers possessions were three-and-outs. Meanwhile, Indianapolis pulled out to a 13-0 lead. In the second quarter, Tanard Jackson intercepted Peyton Manning and set up the Buccaneers' first scoring drive. During the drive, running back Michael Pittman left the game with an injured ankle. Two plays later Tampa Bay got on the board with a Jeff Garcia touchdown pass to Alex Smith, and narrowed the score to 13-7. In the second half, Indianapolis continued to dominate both sides of the ball, and stretched their lead to 30-7. Garcia and Smith connected for a second touchdown pass with just over 9 minutes left in the fourth quarter, and made the score 30-14. Hoping to spark a comeback, Tampa Bay attempted a surprise onside kick, but it was called back by a penalty. Indianapolis then took the re-kick, and put three more points on the board with an Adam Vinatieri field goal. Bruce Gradkowski took over as quarterback for Tampa Bay, and subsequently threw an interception to seal the victory for the Colts. The following day, on Monday, October 8, the Buccaneers announced that Michael Pittman would miss 6-8 weeks with a cracked fibula.
Output: What was the score at the end of the first quarter?
Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal immune disorder characterized by uncontrolled lymphocyte- and macrophage-activation. The resulting hypercytokinemia and cell infiltration of organs lead to the clinical and laboratory features of HLH. Viral infections and other triggers can induce both, inherited and acquired forms of HLH. Disease-causing mutations in the genes encoding perforin (PRF1, FHL2), munc13-4 (UNC13D, FHL3), syntaxin 11 (STX11, FHL4), and munc18-2 (UNC18-2/STXBP2, FHL5) have been previously identified in Familial Hemophagocyic Lymphohistiocytosis (FHL), whereas mutation in RAB27A and LYST account for Griscelli syndome type 2 and Chediak-Higashi syndrome, respectively. These genes all encode proteins which are involved in the cytotoxic activity of lymphocytes. The inability of activated cytotoxic cells to clear antigen-presenting targets results in sustained immune stimulation, likely accounting for the unremitting polyclonal CD8 T-cell activation and hyperimmune reaction which characterizes FHL. Treatment of HLH consists of elimination of the trigger and immunosuppressive treatment in order to induce remission from the uncontrolled inflammation. Allogeneic hematopoietic stem cell transplantation can be indicated in the inherited forms of HLH.
Output: Which syndrome is associated with mutations in the LYST gene?
We Few is the fourth novel in the science fiction Empire of Man series by David Weber and John Ringo.
Output: What series is the episode We Few part of?
The outcrop in the Figure 1.1 is at Checkerboard Mesa in Zion National Park, Utah. It has a very interesting pattern on it. As a geology student you may ask: how did this rock form? If you poke at the rock and analyze its chemistry you will see that its made of sand. In fact, the rock formation is called the Navajo sandstone. But knowing that the rock is sandstone doesnt tell you how it formed. It would be hard to design an experiment to show how this rock formed. But we can make observations now and apply them to this rock that formed long ago. James Hutton came up with this idea in the late 1700s. The present is the key to the past. He called this the principle of uniformitarianism. It is that if we can understand a geological process now and we find evidence of that same Checkerboard Mesa in Zion National Park, Utah. process in the past, then we can assume that the process operated the same way in the past. Hutton speculated that it has taken millions of years to shape the planet, and it is continuing to be changed. He said that there are slow, natural processes that changed, and continue to change, the planets landscape. For example, given enough time, a stream could erode a valley, or sediment could accumulate and form a new landform. Lets go back to that outcrop. What would cause sandstone to have layers that cross each other, a feature called cross-bedding? In the photo of the Mesquite sand dune in Death Valley National Park, California (Figure 1.2), we see that wind can cause cross-bedding in sand. Cross-bedding is due to changes in wind direction. There are also ripples caused by the wind waving over the surface of the dune. Since we can observe wind forming sand dunes with these patterns now, we have a good explanation for how the Navajo sandstone formed. The Navajo sandstone is a rock formed from ancient sand dunes in which wind direction changed from time to time. This is just one example of how geologists use observations they make today to unravel what happened in Earths past. Rocks formed from volcanoes, oceans, rivers, and many other features are deciphered by looking at the geological work those features do today. Click image to the left or use the URL below. URL:
Output: geologists can identify that wind changed direction in ancient sandstone from
Twisted Obsession (original Spanish title: El sueno del mono loco, literally The Dream of the Mad Monkey) is a 1989 Spanish erotic thriller directed by Fernando Trueba, starring Jeff Goldblum and Miranda Richardson.
Output: Which is the basis of Twisted Obsession?
Vegard Skjerve (born 22 May 1988) is a Norwegian footballer who plays as a defender for Haugesund.
Output: What was Vegard Skjerve specialty in their profesisonal sport?
The Battle of al-Qadisiyyah (Arabic: ; transliteration, Ma'rakatu al-Qadisiyyah; Persian: transliteration Nabard-e Qadesiyeh; alternative spellings: Qadisiyya, Qadisiyyah, Kadisiya, Ghadesiyeh), fought in 636, is said to be a decisive engagement between the Arab Muslim army and the Sassanid Persian army during the first period of Muslim expansion.
Output: On what date did Battle of al-Qādisiyyah end?
This study aimed to explore retrospective childhood ADHD symptomatology, psychiatric comorbidity, rates of substance-use disorders (SUD), as well as their association with high-risk health behaviors in prison and adverse health outcomes. A randomly selected representative sample of inmates in the Puerto Rico correctional system (N = 1,179) was assessed with the Spanish-language Wender Utah Rating Scale (WURS); the Composite International Diagnostic Interview (CIDI) modules for lifetime/current major depression disorder (MDD), generalized anxiety disorder (GAD), and SUD; the Davidson Trauma Scale (DTS; posttraumatic stress disorder [PTSD]); and self-reports of in-site high-risk behaviors. Wald (2) tests revealed significant associations of ADHD with MDD and PTSD, as well as increased risk for overdosing and intravenous drug use in prison. A logistic regression model adjusted for mood and anxiety comorbidity predicted lifetime SUD diagnosis (odds ratio = 2.38; 95% confidence interval = [1.15, 4.94]). Our results provide further evidence on the association of drug dependence and ADHD symptoms, and their overrepresentation among prison inmates.
Output: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
The manifestation of Lewy bodies (LB) in the brain is a hallmark of Parkinson's disease. Here, we present a comprehensive analysis of protein elements in Lewy bodies by comparative mass spectrometry. Cortical LB inclusions were enriched by sucrose gradient centrifugation from postmortem brains, and a negative control sample was prepared from specimen without LB pathology. Whereas approximately 550 proteins were identified in the LB-enriched sample by mass spectrometry, quantitative comparison with the control sample revealed that approximately 40 proteins were co-enriched with alpha-synuclein, the major component in Lewy bodies. As expected, the list of proteins included previously reported constituents, such as those involved in protein folding, membrane trafficking and oxidative stress. More interestingly, we discovered in the LB-enriched sample several kinases (MAPKK1/MEK1, protein kinase C, and doublecortin-like kinase), a novel deubiquitinating enzyme (otubain 1), and numerous ubiquitin ligases (KPC and SCF). The proteomic studies provide enzyme candidates to investigate the regulation of alpha-synuclein and/or other LB proteins, which may contribute to the formation of Lewy bodies and the toxicity of alpha-synuclein in the related neurodegenerative disorders.
Output: Which is the primary protein component of Lewy bodies?
The State of Law Coalition (Arabic: I'tilaf Dawlat al-Qanun) also known as Rule of Law Coalition is an Iraqi political coalition formed for the Iraqi governorate elections, 2009 by the Prime Minister of Iraq at the time, Nouri al-Maliki, of the Islamic Dawa Party.
Output: Who led State of Law Coalition?
From Britain to the Middle East and China, engineers and architects are pushing the boundaries of possibility as they strive to create the biggest and the best. Here are recently-selected seven wonders-to-be in the modern world which are near completion. Among these, Beijing Daxing International Airport ranks the first and Hong Kong-Zhuhai-Macau Bridge ranks the third. No.1 Beijing Daxing International Airport, China Beijing Daxing International Airport, which is set to be the biggest airport in the world, is designed by Iraqi-British architect Zaha Hadid. The new Terminal One will have a radial-like plan, designed to reduce passenger travel distances. The construction of the new airport started in 2015 and it is planned to be put into use in 2019. No.2 Kingdom Tower, Jeddah, Saudi Arabia Adrian Smith, the architect who has designed the highest structure in the world, the 829.8 m-high Burj Khalifa in Dubai, is now working on his new project which will smash his own record by this over-a-kilometer-high Kingdom Tower in Jeddah, Saudi Arabia. No one can be sure about the exact date of its completion but most probably the project will be ended in 2019. No.3 Hong Kong-Zhuhai-Macau Bridge, China At about 50 km long, Hong Kong-Zhuhai-Macau Bridge will take the title of the longest water span in the world from another China's bridge in Jiaozhou Bay. The construction started in 2009 and will complete the first session in 2017. No.4 Chernobyl reactor, Ukraine The engineers of the USSR who fought to bring the Chernobyl disaster under control built a concrete sarcophagus to cover the hole that had opened up above the destroyed reactor. A new steel arched structure is being built, to be rolled on rails over the reactor, from which point demolition work can begin using cranes suspended from the new roof. Most possibly it will be finished in 2020. No.5 Hotel Abraj Kudai, Mecca Every hajj, Mecca receives more than two million pilgrims from all over the world. New buildings are being built to accommodate these pilgrims. The Abraj Kudai cluster of towers will hold more than 10,000 hotel rooms. It is expected that the construction work will be put an end to in 2017. No.6 Crossrail, London Crossrail is built to link east and west London through the sewers, cables, and the city's foundations. After its completion in 2017, it is expected to alleviate traffic jams in London. No.7 Grand Stade FFR, Paris Grand Stade FFR is designed especially for the French Rugby Federation. The stadium can accommodate 82,000 fans and is dotted with retractable pitches (a marked out area of ground on which a sport is played). A retractable roof apparatus is capable of turning the stadium into a giant interior. Hopefully the fans can gather there to watch thrilling matches in 2018.
Output: Which building is the highest existing building?
The 2001 shoe bomb attempt was a failed bombing attempt that occurred on December 22, 2001, on American Airlines Flight 63. The aircraft, a Boeing 767-300 with 197 passengers and crew aboard, was flying from Charles de Gaulle Airport in Paris, France, to Miami International Airport in Miami, Florida, United States. The perpetrator, Richard Reid, was subdued by passengers after unsuccessfully attempting to detonate plastic explosives concealed within his shoes. The flight was diverted to Logan International Airport in Boston, under escort by American jet fighters, and safely landed without further incident. Reid was arrested and eventually sentenced to 3 life terms plus 110 years without parole.
Output: What kind of plane did Richard Reid attempt to bomb?
Juliana Sveinsdottir (31 July 1889 -- 1966) was one of Iceland's first female painters and textile artists.
Output: What gender was Júlíana Sveinsdóttir?
According to a new US study, couples who expect their children to help care for them in old age should hope they have daughters because they are likely to be twice as attentive overall. The research by Angelina Grigoryeva, a sociologist at Princeton University, found that, while women provide as much care for their elderly parents as they can manage, men do as little as they can get away with and often leave it to female family members. Her analysis of the family networks of 26,000 older Americans concluded that gender is the most important predictor of whether or not people will actively care for elderly parents. In a paper being presented at the annual conference of the American Sociological Association in San Francisco, she concludes that simply having a sister makes men statistically likely provide less care. Using data from the University of Michigan Health and Retirement Study, a study which has been tracking a cross-section of over-50s for the last decade, she calculated that women provide an average of 12.3 hours a month of care for elderly parents while men offer only 5.6 hours. "Whereas the amount of elderly parent care daughters provide is associated with limitations they face, such as employment or childcare, sons'caregiving is associated only with the presence or absence of other helpers, such as sisters or a parent's spouse ," she explained. "Sons reduce their relative caregiving efforts when they have a sister, while daughters increase theirs when they have a brother." "This suggests that sons pass on parent caregiving responsibilities to their sisters." In the UK, the 2011 census showed that there are now around 6.5 million people with caring responsibilities - a figure which has risen by a tenth in a decade. But many are doing so at the risk of their own health. The census showed that those who provide 50 hours or more of care a week while trying to hold down a full- time job are three times more likely to be struggling with ill health than their working counterparts who are not carers.
Output: What's the most important factor to predict if people will actively care for the elderly?
Marcus Foligno (born August 10, 1991) is an American-Canadian professional ice hockey player, who plays for the Buffalo Sabres of the National Hockey League (NHL).
Output: What team did Marcus Foligno play for?
-Synuclein is the major pathological component of synucleinopathies including Parkinson's disease and dementia with Lewy bodies. Recent studies have demonstrated that -synuclein also plays important roles in the release of synaptic vesicles and synaptic membrane recycling in healthy neurons. However, the precise relationship between the pathogenicity and physiological functions of -synuclein remains to be elucidated. To address this issue, we investigated the subcellular localization of -synuclein in normal and pathological conditions using primary mouse hippocampal neuronal cultures. While some neurons expressed high levels of -synuclein in presynaptic boutons and cell bodies, other neurons either did not or only very weakly expressed the protein. These -synuclein-negative cells were identified as inhibitory neurons by immunostaining with specific antibodies against glutamic acid decarboxylase (GAD), parvalbumin, and somatostatin. In contrast, -synuclein-positive synapses were colocalized with the excitatory synapse marker vesicular glutamate transporter-1. This expression profile of -synuclein was conserved in the hippocampus in vivo. In addition, we found that while presynaptic -synuclein colocalizes with synapsin, a marker of presynaptic vesicles, it is not essential for activity-dependent membrane recycling induced by high potassium treatment. Exogenous supply of preformed fibrils generated by recombinant -synuclein was shown to promote the formation of Lewy body (LB) -like intracellular aggregates involving endogenous -synuclein. GAD-positive neurons did not form LB-like aggregates following treatment with preformed fibrils, however, exogenous expression of human -synuclein allowed intracellular aggregate formation in these cells. These results suggest the presence of a different mechanism for regulation of the expression of -synuclein between excitatory and inhibitory neurons. Furthermore, -synuclein expression levels may determine the efficiency of intracellular aggregate formation in different neuronal subtypes.
Output: Which is the primary protein component of Lewy bodies?
Kell antigens are encoded by the KEL gene on the long arm of chromosome 7. Kx antigen is encoded by the XK gene on the short arm of the X chromosome. Kell and Kx proteins in the red cell membrane are covalently linked by a disulphide bond. The McLeod phenotype is characterized by weakened expression of antigens in the Kell blood group system, absence of Km and Kx antigens, and acanthocytosis. It has an X-linked mode of inheritance with transmission through carrier females. Some males with the McLeod syndrome also have chronic granulomatous disease (CGD). It is generally believed that patients with non-CGD McLeod may develop anti-Km but not anti-Kx, but that those with CGD McLeod can develop both anti-Km and anti-Kx. We present serological data, DNA genotyping and gene sequencing, monocyte monolayer assay and neutrophil oxidative burst test from a patient with the McLeod phenotype without clinical evidence of CGD. We report here the second example of a patient with non-CGD McLeod who developed anti-Kx in addition to anti-Km. Sequencing of our patient's XK gene confirmed the presence of a mutation resulting in a premature stop codon and lack of Kx protein in the red cell membrane, which is consistent with the diagnosis of McLeod syndrome. Neutrophil oxidative burst test was normal, indicating that our patient did not have CGD. The challenge of providing 10 compatible blood units for multiple surgeries was met. The second case of a rare entity, a patient with non-CGD McLeod who developed anti-Kx and anti-Km, was managed successfully with a combination of autologous donations and procurement of compatible units from national and international sources.
Output: Mutation of which gene is associated with McLeod syndrome?
Despite numerous reports implicating NADPH oxidases (Nox) in the pathogenesis of many diseases, precise regulation of this family of professional reactive oxygen species (ROS) producers remains unclear. A unique member of this family, Nox1 oxidase, functions as either a canonical or hybrid system using Nox organizing subunit 1 (NoxO1) or p47(phox), respectively, the latter of which is functional in vascular smooth muscle cells (VSMC). In this manuscript, we identify critical requirement of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50; aka NHERF1) for Nox1 activation and downstream responses. Superoxide (O2 (-)) production induced by angiotensin II (AngII) was absent in mouse EBP50 KO VSMC vs. WT. Moreover, ex vivo incubation of aortas with AngII showed a significant increase in O2 (-) in WT but not EBP50 or Nox1 nulls. Similarly, lipopolysaccharide (LPS)-induced oxidative stress was attenuated in femoral arteries from EBP50 KO vs. WT. In silico analyses confirmed by confocal microscopy, immunoprecipitation, proximity ligation assay, FRET, and gain-/loss-of-function mutagenesis revealed binding of EBP50, via its PDZ domains, to a specific motif in p47(phox) Functional studies revealed AngII-induced hypertrophy was absent in EBP50 KOs, and in VSMC overexpressing EBP50, Nox1 gene silencing abolished VSMC hypertrophy. Finally, ex vivo measurement of lumen diameter in mouse resistance arteries exhibited attenuated AngII-induced vasoconstriction in EBP50 KO vs. WT. Taken together, our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes.
Output: Which NADPH oxidase family member requires interaction with NOXO1 for function?
NKG2D is encoded by KLRK1 gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans.
Output: What is the name of the chromosome where you can find NKG2D?
Viewed as paranoid and dangerous, An Lushan was assassinated in 757 by his own son, An Qingxu, after which the state of Yan continued to spiral into a turmoil that eventually led to its collapse in 763.
Output: What noble family was An Lushan part of?
Sometimes cells need to obtain energy from sugar, but there is no oxygen present to complete cellular respiration. In this situation, cellular respiration can be anaerobic, occurring in the absence of oxygen. In this process, called fermentation, only the first step of respiration, glycolysis, occurs, producing two ATP; no additional ATP is produced. Therefore, the organism only obtains the two ATP molecules per glucose molecule from glycolysis. Compared to the 36-38 ATP produced under aerobic conditions, anaerobic respiration is not a very efficient process. Fermentation allows the first step of cellular respiration to continue and produce some ATP, even without oxygen. Yeast (single-celled eukaryotic organisms) perform alcoholic fermentation in the absence of oxygen. The products of alcoholic fermentation are ethyl alcohol (drinking alcohol) and carbon dioxide gas. This process is used to make common food and drinks. For example, alcoholic fermentation is used to bake bread. The carbon dioxide bubbles allow the bread to rise and become fluffy. Meanwhile, the alcohol evaporates. In wine making, the sugars of grapes are fermented to produce wine. The sugars are the starting materials for glycolysis. Animals and some bacteria and fungi carry out lactic acid fermentation. Lactic acid is a waste product of this process. Our muscles perform lactic acid fermentation during strenuous exercise, since oxygen cannot be delivered to the muscles quickly enough. The buildup of lactic acid is believed to make your muscles sore after exercise. Bacteria that produce lactic acid are used to make cheese and yogurt. The lactic acid causes the proteins in milk to thicken. Lactic acid also causes tooth decay, because bacteria use the sugars in your mouth for energy. Pictured below are some products of fermentation ( Figure 1.1). Products of fermentation include cheese (lactic acid fermentation) and wine (alco- holic fermentation). Behind every fart is an army of gut bacteria undergoing some crazy biochemistry. These bacteria break down the remains of digested food through fermentation, creating gas in the process. Learn what these bacteria have in common with beer brewing at [Link] . Click image to the left or use the URL below. URL:
Output: lactic acid fermentation is used to make which of the following products?
The Varsity Club was a professional wrestling heel stable in the NWA's Jim Crockett Promotions and World Championship Wrestling.
Output: Which industry is The Varsity Club associated with?
RNA editing is proposed as a modulator of transcriptomes, but its biological impact has not been fully elucidated. In particular, its importance for transposable elements is controversial. We found RNA editing on antisense read-through transcripts of KP elements, one of the deletion derivatives of P transposable elements in Drosophila melanogaster. Three kinds of RNA editing were detected at 20 sites around the terminal inverted repeats (TIR); 15 A-to-G, four U-to-C, and one C-to-U conversions. A-to-G conversions are suggested to be attributed to A-to-I RNA editing on KP element RNAs, because inosine (I) in RNA is recognized as G by reverse transcriptase. TIRs were deduced to form dsRNAs as a putative target of ADAR. This is the first report of RNA editing on mobile elements of Drosophila.
Output: Which is the major RNA editing enzyme in Drosophila melanogaster?
Coming off their divisional home win over the Cardinals, the 49ers flew to the Edward Jones Dome for a Week 2 divisional duel against their NFC West rival, the St. Louis Rams. In the first quarter, the Niners trailed early as Rams QB Marc Bulger completed a 12-yard TD pass to WR Torry Holt for the only score of the period. In the second quarter, San Francisco would tie the game up with RB Frank Gore getting a 1-yard TD run. St. Louis would take the halftime lead with kicker Jeff Wilkins getting a 29-yard field goal In the third quarter, the 49ers took the lead with Gore breaking through a gang of tacklers for a 43-yard TD run, along with the only score of the period. In the fourth quarter, the Rams retook the lead with Wiklins getting a 53-yard field goal. Fortunately, thanks to a St. Louis goof-up on special teams, the Niners took the lead with kicker Joe Nedney getting a 40-yard field goal. Near the end the game, the Rams had one last chance to win the game. Fortunately for San Francisco, Wilkins' 56-yard field goal attempt fell about a yard short of the crossbar. With the win, the 49ers improved to 2-0 for the first time since 1998. Q1 - STL - 6:04 - 12-yard TD pass from Marc Bulger to Torry Holt (Wilkins kick) (STL 7-0) Q2 - SF - 14:57 - Frank Gore 1-yard TD run (Nedney kick) (7-7) Q2 - STL - 9:04 - Jeff Wilkins 27-yard FG (STL 10-7) Q2 - STL - 1:51 - Jeff Wilkins 29-yard FG (STL 13-7) Q3 - SF - 2:43 - Frank Gore 43-yard TD run (Nedney kick) (SF 14-13) Q4 - STL - 10:04 - Jeff Wilkins 53-yard FG (STL 16-14) Q4 - SF - 3:23 - Joe Nedney 40-yard FG (SF 17-16)
Output: Who made an attempt at a field goal from the farthest distance?
Georgios Papoulias died from an apparent suicide on September 11, 2009, at the age of 82, following serious health problems.
Output: In one word, how did Georgios Papoulias die?
Ehlers-Danlos syndromes (EDSs) constitute a rare group of inherited connective tissue diseases, characterized by multisystemic manifestations and general tissue fragility. Most severe complications include vascular and gastrointestinal (GI) emergencies requiring acute surgery. The purpose of this systematic review was to assess the causes of GI-related surgery and related mortality and morbidity in patients with EDSs. A systematic search was conducted in PubMed, Embase, and Scopus to identify relevant studies. Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines for systematic reviews were followed. According to eligibility criteria, data were extracted and systematically screened by 2 authors. Screening process identified 11 studies with a total of 1,567 patients. Findings indicated that patients with EDSs had a higher occurrence of surgery demanding GI manifestations, including perforation, hemorrhage, rupture of intra-abdominal organs, and rectal prolapse. Most affected was the vascular subtype, of which up to 33% underwent GI surgery and suffered from a lowered average life expectancy of 48 years (range 6-78). Secondary complications of surgery were common in all patients with EDSs. Studies suggested that patients with EDSs present an increased need for GI surgery, but also an increased risk of surgery-related complications, most predominantly seen in the vascular subtype.
Output: What tissue is most affected in Ehlers-Danlos syndromes?
Focal cortical dysplasia is a malformation of cortical development, which is the most common cause of medically refractory epilepsy in the pediatric population and the second/third most common etiology of medically intractable seizures in adults.Both genetic and acquired factors are involved in the pathogenesis of cortical dysplasia. Numerous classifications of the complex structural abnormalities of focal cortical dysplasia have been proposed - from Taylor et al. in 1971 to the last modification of Palmini classification made by Blumcke in 2011. In general, three types of cortical dysplasia are recognized.Type I focal cortical dysplasia with mild symptomatic expression and late onset, is more often seen in adults, with changes present in the temporal lobe.Clinical symptoms are more severe in type II of cortical dysplasia usually seen in children. In this type, more extensive changes occur outside the temporal lobe with predilection for the frontal lobes.New type III is one of the above dysplasias with associated another principal lesion as hippocampal sclerosis, tumor, vascular malformation or acquired pathology during early life.Brain MRI imaging shows abnormalities in the majority of type II dysplasias and in only some of type I cortical dysplasias.THE MOST COMMON FINDINGS ON MRI IMAGING INCLUDE: focal cortical thickening or thinning, areas of focal brain atrophy, blurring of the gray-white junction, increased signal on T2- and FLAIR-weighted images in the gray and subcortical white matter often tapering toward the ventricle. On the basis of the MRI findings, it is possible to differentiate between type I and type II cortical dysplasia. A complete resection of the epileptogenic zone is required for seizure-free life. MRI imaging is very helpful to identify those patients who are likely to benefit from surgical treatment in a group of patients with drug-resistant epilepsy.However, in type I cortical dysplasia, MR imaging is often normal, and also in both types the lesion seen on MRI may be smaller than the seizure-generating region seen in the EEG. The abnormalities may also involve vital for life brain parts, where curative surgery will not be an option. Therefore, other diagnostic imaging techniques such as FDG PET, MEG, DTI and intra-cranial EEG are widely used to establish the diagnosis and to decide on management.With advances in both genetics and neuroimaging, we may develop a better understanding of patients with drug-resistant epilepsy, which will help us to provide more successful pharmacological and/or surgical treatment in the future.
Output: Which disorder is rated by Palmini classification?
Aging research in vertebrates is hampered by the lack of short-lived models. Annual fishes of the genus Nothobranchius live in East African seasonal ponds. Their life expectancy in the wild is limited by the duration of the wet season and their lifespan in captivity is also short. Nothobranchius are popular aquarium fishes and many different species are kept as captive strains, providing rich material for comparative studies. The present paper aims at reviving the interest in these fishes by reporting that: (1) Nothobranchius can be cultured, and their eggs stored dry at room temperature for months or years, offering inexpensive methods of embryo storage; (2) Nothobranchius show accelerated growth and expression of aging biomarkers at the level of histology and behaviour; (3) the species Nothobranchius furzeri has a maximum lifespan of only 3 months and offers the possibility to perform investigations thus far unthinkable in a vertebrate, such as drug screening with life-long pharmacological treatments and experimental evolution; (4) when the lifespan of different species is compared, a general correlation is found between wet season duration in their natural habitat and longevity in captivity; and (5) vertebrate aging-related genes, such as p66Shc and MTP, can be easily isolated in Nothobranchius by homology cloning. These fishes can become excellent models for aging studies. They can be employed to test the effects of experimental manipulation on aging at a pace comparable with that of Drosophila and to probe the effects of natural selection on the evolution of aging-related genes.
Output: What can Nothobranchius furzeri be used as a model system for?
The 1,204-seat arena at Tundra Oil & Gas Place is home to the Virden Oil Capitals of the Manitoba Junior Hockey League, Virden Oil Kings of the North Central Hockey League, Virden Golden Bears of the Manitoba High School Hockey League, local minor hockey, and local figure skating programs.
Output: What team uses Tundra Oil & Gas Place?
Adelperga and her other sister Liutperga then embarked upon a struggle to regain their patrimony and take revenge upon Charlemagne.
Output: Who is Adelperga's sister?
''Calling Hong Kong'' was the second single by Orange County pop punk band Supernova, released on 7'' by Goldenrod Records in 1993.
Output: Which singer-songwriter  is Calling Hong Kong the fifth studio album of?
The Soviet RPG-22 Netto is a one-shot disposable anti-tank rocket launcher first deployed in 1985, based on the RPG-18 rocket launcher, but firing a larger 72.5 mm fin stabilised projectile.
Output: What was the year RPG-22 entered service?
Democratic Labour Party of Lithuania (Lithuanian: Lietuvos demokratine darbo partija, LDDP) was a social democratic political party in Lithuania, that emerged from the Lithuanian section of the CPSU in December 1989 LDDP was led by Algirdas Brazauskas, the first president of independent Lithuania.
Output: Who led Democratic Labour Party of Lithuania?
Sir William Bowyer-Smijth, 11th Baronet, DL, JP (22 April 1814 -- 20 November 1883) was a British cricketer, baronet and Conservative Party politician.
Output: What noble title does William Bowyer-Smijth hold?
The modern world is full of useful objects that were invented by someone, from spoons and chopsticks in our kitchens to the Ipads in our handbags. Each invention is an example of the creative power of the human mind. Where do inventors get their inspirations ? The inspiration behind each of these inventions varies. Take the shopping cart as an example. Sylvan Goldman was a grocery store owner. Like most businessmen, he wished that his customers would buy more so that he could make more money. He knew what if they could carry more goods easily as they were shopping, when his sales would go up. While thinking about the problem one night, he had an idea. Working with a local handyman named Fred Young, he designed the first shopping cart. Today, retailers who use shopping carts sell more goods and make more profits. Nature has also inspired inventors throughout history. This is what happened to George de Mestral one day. While hunting with his dog in the Swiss Alps, he noticed how the burs of certain plants stuck to his clothing and to his dog' s fur. After examining them under a microscope, he found they had tiny hooks that could easily stick to the fibers of clothing or animal hide. For the next ten years, George de Mestral searched for the hest way to produce his idea. The result of his original inspiration was Velcro, which is used in many modem objects, including sportswear, shoes, automobiles, and even space suits. These examples show us that there are at least two possible inspirations for human creativity in the world of inventions -- profit and nature. No doubt, the future will continue to breathe new life into the economies of the world with fresh ideas and inventions. How many of their creations will be inspired by natural phenomena? The world's problems require creativity and we can expect best solutions from future generations.
Output: According to the article, which invention shows how nature inspires us?
On July 15, 2009 Nucleosys was announced to be disbanding.
Output: What year was the end of Nucleosys?
The District of Keewatin was a territory of Canada and later an administrative district of the Northwest Territories.
Output: What was replaced District of Keewatin?