niryuu/sni-each-converted huggingface dataset:
A personal journey into the heart of the Killing FieldsOne of the most harrowing and compelling personal documentaries of our time, ENEMIES OF THE PEOPLE exposes for the first time the truth about the Killing Fields and the Khmer Rouge who were behind Cambodias horrific genocide. More than simply an inquiry into Cambodias experience, however, ENEMIES OF THE PEOPLE is a profound meditation on the nature of good and evil, shedding light on the capacity of some people to do terrible things and for others to forgive them.Winner of a dozen top documentary festival awards, including a Special Jury Prize at Sundance and the Grand Jury Award at the Full Frame Documentary Festival, this is a riveting film that takes audiences as close to witnessing evil as they are ever likely to get. It is also a personal journey into the heart of darkness by journalist/filmmaker Thet Sambath, whose family was wiped out in the Killing Fields, but whose patience and discipline elicits unprecedented on-camera confessions from perpetrators at all levels of the Khmer Rouge hierarchy. This is investigative journalism of the highest order.In 1974, Thet Sambaths father became one of the nearly two million people who were murdered by the Khmer Rouge when he refused to give them his buffalo. Sambaths mother was forced to marry a Khmer Rouge militiaman and died in childbirth in 1976, while his eldest brother disappeared in 1977. Sambath himself escaped Cambodia at age 10 when the Khmer Rouge fell in 1979.Fast forward to 1998, and Sambath, now a journalist, got to know the children of some senior Khmer Rouge cadre and gradually earned their trust. Then, for a decade, he spent weekends visiting the home of the most senior surviving leader, Nuon Chea, aka Brother Number Two under Pol Pot. But he never used to say anything different from what he told Western journalists, says Sambath, I was low-ranking, I knew nothing, I am not a killer. Then one day he said to me Sambath, I trust you, you are the person I would like to tell my story to. Ask me what you want to know. For the next five years he told me the truth, as he saw it, including all the details of killing.Sambath also won the confidence of lower-level Khmer Rouge soldiers, now ordinary fathers and grandfathers, who demonstrated to him how they slit peoples throats. For these murderers, it was the first time they admitted what they had done. He taped their interactions and discussions about the killings, and together with British documentarian Rob Lemkin they created this landmark film.For Sambath, it has been an ongoing, lifelong personal journey to discover what was behind such horror; he neglected both his family and his own happiness in the search for truth with hope of reconciliation. ENEMIES OF THE PEOPLE is at once a cinematically beautiful, chillingly insightful, and deeply personal piece of documentary filmmaking.
Output: Khoun and Suon take who to the scene of the massacre?
Young people frequently say that they want to exercise, but they just can't find the time. The solution just might be in-office interval training. Recent studies show that very short but intense exercise rapidly builds and maintains fitness and health, even when the workout is only a few minutes long. Work the stairs You can complete an excellent, effective -- and very brief -- workout in an office stairwell, says Martin Gibala, a professor of kinesiology at McMaster University in Canada and an expert on interval training. For a study that he and his colleagues presented earlier this year, they asked 12 out-of-shape women in their 20s to warm up for two minutes by slowly walking up and down stairs in a campus office building. They completed three of these abbreviated stair workouts per week for six weeks. By the end, their aerobic fitness had improved substantially, the researchers reported, by about as much as if they had been running or cycling each week for hours. Fidget your way to fitness. Parents and teachers may once have urged you to sit still, but wiggling, tapping your toes, standing briefly, and otherwise fidgeting as much as possible at your desk is in fact good for your body. In one recent study, college students showed healthier blood flow in their lower legs if they fidgeted than if they did not. Even better, a 2008 study found that among office workers, those who frequently fidgeted burned as many as 300 calories more each day than those who resolutely stayed still.
Output: How many studies are shown in the passage?
Trying to snap a four-game losing skid, the Panthers went home for a Week 12 NFC South rematch with the New Orleans Saints. In the first quarter, Carolina got the early lead as kicker John Kasay managed to get a 45-yard field goal for the only score of the period. In the second quarter, the Saints took the lead as QB Drew Brees completed a 1-yard TD pass to WR Lance Moore, along with kicker Olindo Mare getting a 46-yard field goal. The Panthers would end the half as Kasay nailed a 29-yard field goal. In the third quarter, New Orleans pulled away with Brees completing a 1-yard TD pass to TE Billy Miller, getting an 8-yard TD run, and completing a 4-yard TD pass to WR Marques Colston. With their fifth straight loss, not only did Carolina fall to 4-7, but they had also lost seven straight home games (they have yet to win a home game this year). Also, the Panthers offense only managed to get 4 touchdowns in the last five games.
Output: Which team had the lead in the first quarter?
Traidenis (Polish: Trojden, Belarusian: ) (died 1282) was the Grand Duke of Lithuania from 1270 (or 1269) till 1282.
Output: What noble title does Traidenis hold?
The Rebellion was the career highlight for both leaders; Cumberland resigned from the Army in 1757 and died of a stroke in 1765. Charles was initially treated as a hero on his return to Paris but the Stuarts were once again barred from France by the 1748 Treaty of Aix-la-Chapelle. Henry Stuart's entry into the Catholic Church in June 1747 was seen as tacit acceptance the Jacobites were finished and Charles never forgave him. He continued attempts to reignite the cause, including a secret visit to London in 1750 but habitual heavy drinking made him argumentative and hard to work with. In 1759, he met French Chief Minister de Choiseul to discuss another invasion attempt but Choiseul dismissed him as incapable through drink. When his father James died in 1766, Pope Clement XIII refused to recognise him as Charles III, despite the strong objections of his brother Henry. Charles never visited Britain again and died in Rome in January 1788, a disappointed and embittered man.
Output: Which happened first, Charles secret visit to London or his meeting with French Chief Minister de Choiseul?
The Anaspidoglanis boutchangai is considered to be of least concern to becoming an endangered species.
Output: How endangered does the iucn consider Anaspidoglanis boutchangai?
It's not the first movie to show the end of the world. But in the latest box office hit 2012 it is neither aliens nor a killer disease that threaten the human race, but climate change. Some say the film lacks good dialogue and its science is questionable, others believe German director Roland Emmerich makes up for these flaws in special effects. An earthquake destroys the White House and Yellow stone National Park ends up in flames. Emmerich borrows from the old Mayan story which says, that the world will end in 2012.He is being criticized for Internet rumors about doomsday "There is no factual basis for these claims,'' NASA said on its website. "Credible scientists worldwide know of no threat connected with 2012,'' it insisted. "After all, our planet has been getting along just fine for more than 4 billion years, " they added. According to the UK's Daily Telegraph, it was first thought that the disaster would happen in May 2003. When the world continued, supporters picked the last day of the Mayan calendar. "Every culture has a myth of destruction , just as they have a myth of creation. These myths |of destruction tend to surface during times of crisis , " Michael A. Ryan, an assistant profess of history,speaking to Purdue University News. Ryan studies apocalyptic themes from the Middle Ages at the US university. "Today's current economic climate is a state of crisis for many people who are worried whether they can afford to feed themselves,"he added.
Output: What led to the end of the world according to the film 2012?
IDW Publishing is an American publisher of comic books, graphic novels, art books and comic strip collections.
Output: The product of IDW Publishing is what?
The Packers were trailing the winless Cleveland Browns 14-7 in the third quarter. The Browns scored a touchdown to make it 21-7, but Hundley and the Packers responded with a touchdown drive of their own, making it 21-14. The Packers tied the game with 17 seconds left on a touchdown pass to Davante Adams. In overtime, Browns quarterback DeShone Kizer threw a costly interception to Josh Jones, and Adams took a screen pass to the end zone, improving the Packers record to 7-6 and setting the stage for Aaron Rodgers' comeback.
Output: Who was winning in the 3rd quarter?
Diabetic nephropathy is the leading cause of end-stage renal disease in humans in the Western world. The recent development of Na+-glucose cotransporter 2 (SGLT2) inhibitors offers a new antidiabetic therapy via enhanced glucose excretion. Whether this strategy exerts beneficial effects on the development of type 2 diabetic nephropathy is still largely unclear. We investigated the effects of the specific SGLT2 inhibitor empagliflozin in BTBR.Cg-Lep<ob>/WiscJ (BTBR ob/ob) mice, which spontaneously develop type 2 diabetic nephropathy. In the first experiment, BTBR ob/ob mice received either a diet containing 300 ppm empagliflozin or equicaloric placebo chow for 12 wk. In the second experiment, BTBR ob/ob mice received 1 gkg body wt(-1)day(-1) ANG II to induce arterial hypertension and were separated into the same two diet groups for 6 wk. In both experiments, empagliflozin treatment enhanced glucosuria, thereby lowering blood glucose. Independently of hypertension, empagliflozin reduced albuminuria in diabetic mice. However, empagliflozin treatment affected diabetes-related glomerular hypertrophy, markers of renal inflammation, and mesangial matrix expansion only in BTBR ob/ob mice without hypertension. In summary, empagliflozin demonstrated significant antihyperglycemic effects, differentially ameliorating early features of diabetic nephropathy in BTBR ob/ob mice with and without hypertension.
Output: Which protein does empagliflozin inhibit?
Top 5 Must See Places in Beijing Beijing is an old capital city with a lot of tourists attractions. What is the most representative place in Beijing? The answers are various. Here are the Top 5 Must See Places in Beijing. 1. Forbidden City The Forbidden City is the ideal place for you to begin your exploration of Beijing. Make sure to wear comfortable shoes as you have to walk a lot! A multilingual guide recorder is recommended, as it can tell you the stories behind the palace. Opening Hour: 8:30-17:00 Entrance Fee: RMB 60 2. Tian'anmen Square Lying in the heart of Beijing City, it is the place for massive parades and gathering. It boasts of the largest square of such kind in the world. At sunrise and sunset the raising and lowering ceremony of the Chinese National Flag is well worth seeing. Ticket fees: Free Opening Time: Whole Day 3. Great Wall Most of the sections of the Great Wall in Beijing are well-preserved, and the most famous section is Badaling. For the Great Wall hiking, get ready for strong footwear. For hot weather, please also prepare sunblock, sunglasses and water. Badaling Great Wall: Ticket Fees: RMB40 (Nov. 01 to Mar. 31); RMB 45 (Apr. 01 to Oct. 31) Open Hours: 6:40 to 18:30 4. Summer Palace Regarded as the largest imperial garden in China, the Summer Palace is in fact a park-styled royal retreat. With masterly design and artistic architecture integrating the highlight of Chinese garden arts, it has earned a title of "Royal Garden Museum". Open Time: 6:30-20:30 Ticket Fee: RMB 40 (low season) / RMB 50 (peak season during the holidays) 5. Temple of Heaven The Temple of Heaven worked as sacrificial compound buildings for the Ming and Qing emperors. What's the intriguing by-production of the temple is that if you enter the Temple of Heaven in the early morning, you can find many people doing all types of Kungfu, Taiji, dancing and other morning exercises. Open Time: 6:00-21:00 Ticket Fee: RMB 35
Output: Which is the most suitable place for those who want to go square dancing in the morning?
Previously, autosomal dominant catecholaminergic polymorphic ventricular tachycardia (CPVT [1]) was mapped to chromosome 1q42-43 with identification of pathogenic mutations in RYR2. Autosomal recessive CPVT (2) was mapped to chromosome 1p13-21, leading to the identification of mutations in CASQ2. In this study, we aimed to elucidate clinical phenotypes of a new variant of CPVT (3) in an inbred Arab family and also delineate the chromosomal location of the gene causing CPVT (3). In a highly inbred family, clinical symptoms of CPVT appeared early in childhood (7-12 years) and in three of the four cases, the first appearance of symptoms turned into a fatal outcome. Parents of the affected children were first-degree cousins and without any symptoms. Segregation analysis suggested an autosomal recessive inheritance. A genome-wide search using polymorphic DNA markers mapped the disease locus to a 25-Mb interval on chromosome 7p14-p22. A maximal multipoint LOD score of 3.17 was obtained at marker D7S493. Sequencing of putative candidate genes, SP4, NPY, FKBP9, FKBP14, PDE1C, and TBX20, in and around this locus, did not reveal any mutation. We have identified a novel highly malignant autosomal recessive form of CPVT and mapped this disorder to a 25-Mb interval on chromosome 7p14-p22.
Output: What is the inheritance pattern of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) caused by RYR2 mutations?
The Volme is a river in North Rhine-Westphalia, Germany, a left tributary of the Ruhr.
Output: Which river system contains Volme?
Saint Juan Garcia Lopez-Rico (10 July 1561 -- 14 February 1613) was a Spanish Roman Catholic priest from the Trinitarian Order who would establish a branch of his order which he named the Order of Discalced Carmelites.
Output: What group was Juan García López-Rico a member of?
According to the United States Department of Labors Bureau of Labor Statistics, there were approximately 210,900 physical therapists employed in the United States in 2014, earning an average $84,020 annually in 2015, or $40.40 per hour, with 34% growth in employment projected by the year 2024. The Bureau of Labor Statistics also reports that there were approximately 128,700 Physical Therapist Assistants and Aides employed in the United States in 2014, earning an average $42,980 annually, or $20.66 per hour, with 40% growth in employment projected by the year 2024. To meet their needs, many healthcare and physical therapy facilities hire "travel physical therapists", who work temporary assignments between 8 and 26 weeks for much higher wages; about $113,500 a year. Bureau of Labor Statistics data on PTAs and Techs can be difficult to decipher, due to their tendency to report data on these job fields collectively rather than separately. O-Net reports that in 2015, PTAs in the United States earned a median wage of $55,170 annually or $26.52 hourly, and that Aides/Techs earned a median wage of $25,120 annually or $12.08 hourly in 2015. The American Physical Therapy Association reports vacancy rates for physical therapists as 11.2% in outpatient private practice, 10% in acute care settings, and 12.1% in skilled nursing facilities. The APTA also reports turnover rates for physical therapists as 10.7% in outpatient private practice, 11.9% in acute care settings, 27.6% in skilled nursing facilities.
Output: What group has the highest percentage of vacancy for Physical Therapist Assistants?
Imatinib is one of the most recent medications used for the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). It is an orally administered protein-tyrosine kinase inhibitor, an enzyme which is produced by BCR-ABL fusion which results from translocation of 9:22 chromosome (Philadelphia chromosome). Imatinib blocks proliferation and induces apoptosis of BCR-ABL-expression in CML. Many side effects produced by imatinib have been documented but its induction of hepatotoxcity has been rarely reported. Only a few cases so far have been reported in the literature and almost all were in females. We describe another case of hepatotoxicity due to imatinib in a 17-year old female with clinical, laboratory and histopathological changes. The case described here suggests that imatinib may also induce immune hepatitis, in some patients.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Have you ever thought about why malls, restaurants, and even theaters have music? Well, to understand this, you simply just look back at how you felt when you heard music in these places. Music is known to improve the mood of people. Often music helps us pay attention to what we are doing. Music helps patients feel good and helps them recover faster and better. Depression is a state of mind that most of us experience at some point of time. There are some periods in our life when everything seems difficult. It seems that everything is getting worse and we have no control over our life. Studies have shown that music can be an important mood lifter in such situations. Music also plays a great role in making us feel less nervous or worried. Anxiety can often cause loss of sleep and other illnesses. Music is often known as an international language. We may not know the language another person is speaking, but most of us respond to music in the same way. Music can often be the best way to connect with someone. Music is one of the best ways to improve your moods, but this can depend largely on the kind of music you listen to. While happy music can certainly make you feel better, sad music can further lower your spirits. Listening to classical music can often make you feel a lot more powerful, while soft music can be the perfect way to relax at the end of a long way. If you want to use music to change the way how you are feeling, you need to understand the role of it, learn to recognize the kind of music that lifts your mood and helps you feel better. Once you realize the kind of music you can use, you can use it to change the way you feel. The right kind of music can be the perfect way to help us feel happier.
Output: According to the passage, which kind of music can relax ourselves from a long day's work?
Elisabeth of the Palatinate (26 December 1618 -- 11 February 1680), also known as Elisabeth of Bohemia, Princess Elisabeth of the Palatinate, or Princess-Abbess of Herford Abbey, was the eldest daughter of Frederick V, Elector Palatine (who was briefly King of Bohemia), and Elizabeth Stuart.
Output: Who is the paternal progenitor of Elisabeth of the Palatinate?
Spectrin, the major component of the erythroid membrane skeleton, is a long, asymmetrical rodlike protein that interacts with several other proteins to form a two-dimensional membrane skeleton. Progress in several laboratories over the past few years including substantial partial peptide and nucleotide sequence determination has greatly enhanced our knowledge of the structural properties of this large molecule (heterodimer = 465,000 daltons). The alpha and beta subunits are homologous with approximately 30% identity. They are aligned in an antiparallel side-to-side orientation with the amino- and carboxy-termini near opposite physical ends of the molecule. The predominant structural feature elucidated from sequencing this large molecule is the nearly universal occurrence in both subunits of a single type of repetitive structure. The periodicity of this homologous structure is exactly 106 amino acid residues. As many as 36 homologous, but nonidentical, repeats exist and comprise more than 90% of the mass of the heterodimer. Each of these repetitive units is folded into a triple-stranded structure that is highly helical. Peptide maps, antibody crossreactivity, peptide sequence analysis, and more recently nucleic acid sequences have defined several major properties of the erythroid molecule and related proteins in other tissues. Tissue-specific spectrins have the same 106-residue repetitive structure and show sequence homology to erythroid spectrin.
Output: Alpha-spectrin and beta-spectrin subunits form parallel or antiparallel heterodimers?
Crouching Woman is a bronze sculpture by Auguste Rodin.
Output: What is the surface of Crouching Woman made of?
Selenocysteine (Sec), the 21st amino acid in protein, is encoded by UGA. The Sec insertion sequence (SECIS) element, which is the stem-loop structure present in 3' untranslated regions (UTRs) of eukaryotic selenoprotein-encoding genes, is essential for recognition of UGA as a codon for Sec rather than as a stop signal. We now report the identification of a new eukaryotic selenoprotein, designated selenoprotein M (SelM). The 3-kb human SelM-encoding gene has five exons and is located on chromosome 22 but has not been correctly identified by either Celera or the public Human Genome Project. We characterized human and mouse SelM cDNA sequences and expressed the selenoprotein in various mammalian cell lines. The 3" UTR of the human, mouse, and rat SelM-encoding genes lacks a canonical SECIS element. Instead, Sec is incorporated in response to a conserved mRNA structure, in which cytidines are present in place of the adenosines previously considered invariant. Substitution of adenosines for cytidines did not alter Sec incorporation; however, other mutant structures did not support selenoprotein synthesis, demonstrating that this new form of SECIS element is functional. SelM is expressed in a variety of tissues, with increased levels in the brain. It is localized to the perinuclear structures, and its N-terminal signal peptide is necessary for protein translocation.
Output: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
USA-88 was launched at 02:55:00 UTC on 3 February 1993, atop a Delta II carrier rocket, flight number D218, flying in the 7925-9.5 configuration.
Output: On what date was USA-88 launched?
However, the Seven Years' War ended on February 10, 1763 with the signing of the Treaty of Paris in Paris, France. Also, Silang was assassinated on May 28, 1763 by an Indio under the employ of the friars. The Spanish were then able to focus on the uprising and mustered forces to surround Palaris. The Spanish friars, who were allowed to stay in the province, also started a campaign to persuade Pangasinan residents of the futility of the Palaris Revolt. By September 1763, news of the peace treaty reached Pangasinan and army of Palaris' men surrendered and returned to normal life amid the Spanish offensive. Palaris tried to fend off the offensive at the village of Mabalitec near the Agno River between Binalatongan and Bayambang in December 1763. To prevent the Spanish from seeking lodging in his hometown, he ordered his men to raze Binalatongan. But the Spanish won the Battle of Mabalitec, demoralizing Palaris' forces. The town of Binalatongan was rebuilt in another site between December 1763 to June 1764 and renamed San Carlos , in honor of the reigning King Carlos III of Spain. Palaris' forces made a last stand at the town of San Jacinto, Pangasinan, but they were defeated. Palaris' advisers, Andres Lopez and Juan de Vera Oncantin, were captured. They would later be hanged.
Output: Who returned to normal life?
''Anymore'' is a song co-written and recorded by American country music artist Travis Tritt.
Output: Who sang or played Anymore?
Christianson syndrome (CS) is an X-linked neurodevelopmental and neurological disorder characterized in males by core symptoms that include non-verbal status, intellectual disability, epilepsy, truncal ataxia, postnatal microcephaly and hyperkinesis. CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in early recycling endosomes. The extent and variability of the CS phenotype in female heterozygotes, who presumably express the wild-type and mutant SLC9A6 alleles mosaically as a result of X-chromosome inactivation (XCI), have not yet been systematically characterized. Slc9a6 knockout mice (Slc9a6 KO) were generated by insertion of the bacterial lacZ/-galactosidase (-Gal) reporter into exon 6 of the X-linked gene. Mutant Slc9a6 KO male mice have been shown to develop late endosomal/lysosomal dysfunction associated with glycolipid accumulation in selected neuronal populations and patterned degeneration of Purkinje cells (PCs). In heterozygous female Slc9a6 KO mice, -Gal serves as a transcriptional/XCI reporter and thus facilitates testing of effects of mosaic expression of the mutant allele on penetrance of the abnormal phenotype. Using -Gal, we demonstrated mosaic expression of the mutant Slc9a6 allele and mosaically distributed lysosomal glycolipid accumulation and PC pathology in the brains of heterozygous Slc9a6 KO female mice. At the behavioral level, we showed that heterozygous female mice suffer from visuospatial memory and motor coordination deficits similar to but less severe than those observed in X-chromosome hemizygous mutant males. Our studies in heterozygous Slc9a6 KO female mice provide important clues for understanding the likely phenotypic range of Christianson syndrome among females heterozygous for SLC9A6 mutations and might improve diagnostic practice and genetic counseling by helping to characterize this presumably underappreciated patient/carrier group.
Output: Mutation of which gene is implicated in the Christianson syndrome?
EDGEWOOD-Every morning at Dixie Heights High school,customers pour into a special experiment:the district's first coffee shop run mostly by students with special learning needs. Well before classes start,students and teachers order Lattes,Cappuccinos and Hot Chocolates.Then,during the first period,teachers call in orders on their room phones,and students make deliveries.By closing time at 9:20a.m.,the shop usually sells 90drinks."Whoever made the chi tea,Ms.Schatzman says it was good,"Christy McKinley,a second year student,announced recently,after hanging up with the teacher. The shop is called the Dixie PIT,which stands for Power in Transition.Although some of the students are not disabled,many are,and the PIT helps them prepare for life after high school.They learn not only how to run a coffee shop but also how to deal with their affairs.They keep a timecard and receive paychecks,which they keep in check registers. Special-education teachers Kim Chevalier and Sue Casey introduced the Dixie PIT from a similar program at Kennesaw Mountain High School in Georgia.Not that it was easy.Chevalier's first problem to overcome was product-related.Should schools be selling coffee?What about sugar content?Kenton County Food Service Director Ginger Gray helped.She made sure all the drinks,which use non-fat milk,fell within nutrition guidelines.
Output: The coffee shop is mostly run by    .
On 1 April 1911, Porfirio Diaz claimed that he had heard the voice of the people of Mexico, replaced his cabinet, and agreed to restitution of the lands of the dispossessed. Madero did not believe this statement and instead demanded the resignation of President Diaz and Vice-President Ramon Corral. Madero then attended a meeting with the other revolutionary leaders- they agreed to a fourteen-point plan which called for pay for revolutionary soldiers; the release of political prisoners; and the right of the revolutionaries to name several members of cabinet. Madero was moderate, however. He believed that the revolutionaries should proceed cautiously so as to minimize bloodshed and should strike a deal with Diaz if possible. In May, Madero wanted a ceasefire, but his fellow revolutionaries Pascual Orozco and Francisco Villa disagreed and went ahead with an attack on Ciudad Juarez. The revolutionaries won this battle decisively and on 21 May 1911, the Treaty of Ciudad Juarez was signed. Under the terms of the Treaty of Ciudad Juarez, Diaz and Corral agreed to resign by the end of May 1911, with Diaz's Minister of Foreign Affairs, Francisco Leon de la Barra, taking over as interim president solely for the purpose of calling general elections. This first phase of the Mexican Revolution thus ended with Diaz leaving for exile in Europe at the end of May 1911. On 7 June 1911, Madero entered Mexico City in triumph where he was greeted with huge crowds shouting "Viva Madero!"
Output: What happened second, Díaz leaving for exile in Europe or Díaz claiming that he had heard the voice of the people of Mexico?
The Capri Theatre is a cinema in Goodwood, a suburb of Adelaide, South Australia, built in the Art Deco style.
Output: Of what style is Capri Theatre?
Imatinib was developed as the first molecularly targeted therapy to specifically inhibit the BCR-ABL kinase in Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML). Because of the excellent hematologic and cytogenetic responses, imatinib has moved toward first-line treatment for newly diagnosed CML. However, the emergence of resistance to imatinib remains a major problem in the treatment of Ph-positive leukemia. Several mechanisms of imatinib resistance have been identified, including BCR-ABL gene amplification that leads to overexpression of the BCR-ABL protein, point mutations in the BCR-ABL kinase domain that interfere with imatinib binding, and point mutations outside of the kinase domain that allosterically inhibit imatinib binding to BCR-ABL. The need for alternative or additional treatment for imatinib-resistant BCR-ABL-positive leukemia has guided the way to the design of a second generation of targeted therapies, which has resulted mainly in the development of novel small-molecule inhibitors such as AMN107, dasatinib, NS-187, and ON012380. The major goal of these efforts is to create new compounds that are more potent than imatinib and/or more effective against imatinib-resistant BCR-ABL clones. In this review, we discuss the next generation of BCR-ABL kinase inhibitors for overcoming imatinib resistance.
Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
The Conquest of Melilla occurred in September 1497, when a fleet sent by the Duke of Medina Sidonia seized the north African city of Melilla., as continuation of Reconquest of Mauritania Tingitana During the 15th century the mediterranean cities of the Sultanate of Fez fell in decadence in opposition to cities located in the Atlantic facade, which concentrated most of the economic activity. By the end of the 15th century, the port of Melilla, that had been often disputed between the rulers of Fez and Tlemcen, was nearly abandoned. Plans for the conquest occurred as soon as the Fall of Granada in 1492. Spanish captains Lezcano and Lorenzo Zafra visited the coast of Northern Africa to identify possible locations for the Spanish to overtake, and Melilla was identified as a prime candidate. Melilla was, however, in the Portuguese zone of influence under the terms of the 1479 Treaty of Alcacovaz. At Tordesillas in 1494, King John II of Portugal, the Portuguese ruler agreed to make an exception and permitted the Spanish to attempt the conquest of Melilla. The duke sent Pedro Estopinan who conquered the city virtually without a fight in 1497, as internal conflicts had depleted it of troops, and its defenses were weakened. The Wattasid ruler Muhammad al-Shaykh sent a detachment of cavalrymen to retake control of the city, but they were repulsed by the guns of the Spanish ships.
Output: What happened second: The Conquest of Melilla or Treaty of Alcáçovaz?
Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin excretion and hyperbilirubinemia syndromes is largely understood, but that of Rotor syndrome, an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, coproporphyrinuria, and near-absent hepatic uptake of anionic diagnostics, has remained enigmatic. Here, we analyzed 8 Rotor-syndrome families and found that Rotor syndrome was linked to mutations predicted to cause complete and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP1B3. These important detoxification-limiting proteins mediate uptake and clearance of countless drugs and drug conjugates across the sinusoidal hepatocyte membrane. OATP1B1 polymorphisms have previously been linked to drug hypersensitivities. Using mice deficient in Oatp1a/1b and in the multispecific sinusoidal export pump Abcc3, we found that Abcc3 secretes bilirubin conjugates into the blood, while Oatp1a/1b transporters mediate their hepatic re uptake. Transgenic expression of human OATP1B1 or OATP1B3 restored the function of this detoxification-enhancing liver-blood shuttle in Oatp1a/1b-deficient mice. Within liver lobules, this shuttle may allow flexible transfer of bilirubin conjugates (and probably also drug conjugates) formed in upstream hepatocytes to downstream hepatocytes, thereby preventing local saturation of further detoxification processes and hepatocyte toxic injury. Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubinemia.Moreover, OATP1B1 and OATP1B3 null mutations may confer substantial drug toxicity risks.
Output: Which syndrome is associated with OATP1B1 and OATP1B3 deficiency?
Progress M-15 was launched at 17:19:41 GMT on 27 October 1992, atop a Soyuz-U2 carrier rocket flying from Site 31/6 at the Baikonur Cosmodrome.
Output: On what date was Progress M-15 launched?
Osteoporosis and several other bone disorders occur when there is an imbalance between the resorption and formation components of bone remodeling activity. Therapies available for some of these conditions modulate the activity of osteoclasts and/or osteoblasts. The recent discoveries of receptor activator of NF-kappaB ligand (RANKL), an endogenous activator of osteoclastogenenesis and osteoclast activity and its inhibitor, osteoprotegerin (OPG) as pivotal regulatory factors in the pathogenesis of bone diseases like osteoporosis provide unique targets for therapeutic agents. In laboratory animals and now in humans, administering forms of OPG markedly inhibits osteoclast activity and improves bone strength, documenting that the strategy of inhibiting RANKL activity has therapeutic promise. A highly specific, fully human antibody against RANKL has been produced (denosumab) that in early studies in humans reduces bone turnover and improves bone density. Attributes of denosumab in these clinical studies include a very rapid onset of action, sustained effects for several months after a single injection, and good tolerability. These results provide the basis for studies evaluating the effectiveness of denosumab in several clinical conditions characterized by increased osteoclastic activity.
Output: To the ligand of which receptors does Denosumab (Prolia) bind?
After the defeat of several Song armies in the north, Emperor Qinzong wanted to negotiate a truce with the Jin, but he committed a massive strategic blunder when he commanded his remaining armies to protect prefectural cities instead of Kaifeng. Neglecting the importance of the capital, he left Kaifeng defended with fewer than 100,000 soldiers. The Song forces were dispersed throughout China, powerless to stop the second Jurchen siege of the city. The Jin assault commenced in mid December 1126. Even as fighting raged on, Qinzong continued to sue for peace, but Jin demands for territory were enormous: they wanted all provinces north of the Yellow River. After more than twenty days of heavy combat against the besieging forces, Song defenses were decimated and the morale of Song soldiers was on the decline. On January 9, 1127, the Jurchens broke through and started to loot the conquered city. Emperor Qinzong tried to appease the victors by offering the remaining wealth of the capital. The royal treasury was emptied and the belongings of the city's residents were seized. The Song emperor offered his unconditional surrender a few days later. Qinzong, the former emperor Huizong, and members of the Song court were captured by the Jurchens as hostages. They were taken north to Huining , where they were stripped of their royal privileges and reduced to commoners. The former emperors were humiliated by their captors. They were mocked with disparaging titles like "Muddled Virtue" and "Double Muddled". In 1128 the Jin made them perform a ritual meant for war criminals. The harsh treatment of the Song royalty softened after the death of Huizong in 1135. Titles were granted to the deceased monarch, and his son Qinzong was promoted to Duke, a position with a salary.
Output: Which happened first, the seizing of the resident's belongings to give to the Jin, or unconditional surrender of the Song emperor?
Helen Cunningham (previously Richardson) is a fictional character from the long-running Channel 4 soap opera, Hollyoaks, played by Kathryn George.
Output: In what fictional work would you find a character named Helen Cunningham?
The Caste War of Yucatan was a conflict that lasted from 1847 to 1901. It began with the revolt of native Maya people led by Maya chiefs Jacinto Pat and Cecilio Chi, against the population of European descent called "Yucatecos", who had political and economic control. A lengthy war ensued between the Yucateco forces in the north-west of the Yucatan and the independent Maya in the south-east. It officially ended with the occupation of the Maya capital of Chan Santa Cruz by the Mexican army in 1901, although skirmishes with villages and small settlements that refused to acknowledge Mexican control continued for over another decade. Adam Jones wrote: "This ferocious race war featured genocidal atrocities on both sides, with up to 200,000 killed." Because of the conflict, on November 24, 1902, Yucatan had a second territorial division when Porfirio Diaz decreed the creation of the Federal Territory of Quintana Roo, with capital in the port of Payo Obispo . In little more than half a century, Yucatan lost more than two thirds of its original territory.
Output: Who did the Maya wage war with?
MS Viking Cinderella is a cruiseferry built in 1989 at Wartsila Marine Perno Shipyard in Turku, Finland, as MS Cinderella for SF Line, one of the owners of the Viking Line consortium.
Output: Which corporation created MS Viking Cinderella?
Mercy Now is the fourth studio album by Mary Gauthier.
Output: What label was responsible for Mercy Now?
Ali Sadiki (born 10 December 1987) is a Zimbabwean professional footballer, who plays as a defender for TP Mazembe in DR Congo.
Output: Which sports team is Ali Sadiki playing for?
Energy travels through space or material. This is obvious when you stand near a fire and feel its warmth or when you pick up the handle of a metal pot even though the handle is not sitting directly on the hot stove. Invisible energy waves can travel through air, glass, and even the vacuum of outer space. These waves have electrical and magnetic properties, so they are called electromagnetic waves. The transfer of energy from one object to another through electromagnetic waves is known as radiation. Different wavelengths of energy create different types of electromagnetic waves (Figure 1.1). The wavelengths humans can see are known as visible light. When viewed together, all of the wavelengths of visible light appear white. But a prism or water droplets can break the white light into different wavelengths so that separate colors appear (Figure 1.2). What objects can you think of that radiate visible light? Two include the Sun and a light bulb. The longest wavelengths of visible light appear red. Infrared wavelengths are longer than visible red. Snakes can see infrared energy. We feel infrared energy as heat. Wavelengths that are shorter than violet are called ultraviolet. Can you think of some objects that appear to radiate visible light, but actually do not? The Moon and the planets do not emit light of their own; they reflect the light of the Sun. Reflection is when light (or another wave) bounces back from a surface. Albedo is a measure of how well a surface reflects light. A surface with high albedo reflects a large percentage of light. A snow field has high albedo. One important fact to remember is that energy cannot be created or destroyed it can only be changed from one form to another. This is such a fundamental fact of nature that it is a law: the law of conservation of energy. In photosynthesis, for example, plants convert solar energy into chemical energy that they can use. They do not create new energy. When energy is transformed, some nearly always becomes heat. Heat transfers between materials easily, from warmer objects to cooler ones. If no more heat is added, eventually all of a material will reach the same temperature.
Output: if you live in a desert, the best car to buy to avoid a hot interior is one that is
Iron deficiency is the most common nutritional disorder affecting at least one third of world's population. Though anemia is common manifestation of iron deficiency, other effects of iron deficiency on various tissues, organs and systems are usually under recognized. Impaired brain development and cognitive, behavioural and psychomotor impairment are most worrisome manifestations of iron deficiency. Studies have demonstrated that some of these changes occurring during period of brain growth spurt (<2 years age) may be irreversible. Association of iron deficiency with febrile seizures, pica, breath holding spells, restless leg syndrome and thrombosis is increasingly being recognized. Impaired cell-mediated immunity and bactericidal function are generally noted in iron-deficient persons; however, the findings are inconsistent. Despite proven reversible functional immunological defects in vitro studies, a clinically important relationship between states of iron deficiency and susceptibility to infections remains controversial. Studies from malaria endemic regions have reported increased incidence of malaria in association with iron supplementation. These and some other aspects of iron deficiency are reviewed in this article.
Output: Which deficiency is the cause of restless leg syndrome?
The Veil Nebula is a cloud of heated and ionized gas and dust in the constellation Cygnus.
Output: What is the name of the constellation which Veil Nebula belongs?
The 2013 International Championship was a professional ranking snooker tournament that took place between 27 October and 3 November 2013 at the Chengdu Eastern Music Park in Chengdu, China.
Output: On what date did 2013 International Championship end?
Live Music--Late Night Jazz Enjoy real American jazz from Herbie Davis, the famous trumpet player. Heis known to play well into the late hours, so don't expect to get much sleep. Place: The Jazz Club Dates : 10 - 25 July Price: $ 100 -- 150 Time: 10:30 p.m. till late Tel: 4668736 Scottish Dancing Scottish dancing is nice and easy to learn. The wonderful dance from Britain will beshown. Place: Jack Stein's Dates :12 -19 July Price: $150 Time: 7:00 p.m.-10:00 p.m. Tel: 4021877 Shows in Shanxi Museum There are 12,000 pieces on show here. You can see the whole Chinese history. Place: Shanxi Museum Dates: Jun 1 - Aug 15 Price: $ 60 ( $ 30 for students) Time: Monday - Friday 9:00 a.m. - 5:00 p.m. Tel : 4886888 Weekends: 9:00 a.m.-9:00 p.m.
Output: Which number should you call if you like jazz music?
After a win at Cleveland, the Steelers traveled to Baltimore to take on the Ravens in what would be the Thanksgiving Primetime Game and of course their first game on Thanksgiving Day since 1998. The Ravens drew first blood as Joe Flacco found Torrey Smith on a 7-yard pass to make the score 7-0 in the first quarter. In then 2nd quarter, Justin Tucker nailed a 43-yard field goal for a 10-0 halftime lead. After the break, the Ravens went back to work in the 3rd quarter as Tucker nailed a 34-yard field goal for a 13-0 lead. The Steelers finally got on the board asBen Roethlisberger found Emmanuel Sanders on an 8-yard touchdown pass for a 13-7 score. The Ravens then pulled away as Tucker kicked yet another field goal putting his team ahead by 9, 16-7. In the 4th quarter, Tucker kicked yet another field goal this one from 45 yards out for a score of 19-7. The Steelers managed to draw within 5 points 19-14 when Le'Veon Bell ran for a 1-yard touchdown. Tucker then kicked a 48-yard field goal to make the score 22-14. The Steelers started their comeback attempt as Roethlisberger found Jerricho Cotchery on a 1-yard touchdown pass for a 22-20 score. After this, they tried the 2-point conversion to tie the game and send it into OT, but they would come up short and miss the conversion with 1:03 left in the game. This dropped the team to 5-7 and 3rd place in the AFC North. Also they dropped to 2-5 on Thanksgiving.
Output: Which team went scoreless in the first quarter?
In Week 8, the Bears donned their 1940s throwback uniforms against the Carolina Panthers, who had the worst record in the NFC. The Bears scored first on Matt Forte's 13-yard touchdown run, which would be countered by Justin Medlock's 34-yard field goal. The Panthers then took the lead on Louis Murphy's fumble recovery; Panthers quarterback Cam Newton ran with the ball, and lost the ball when Bears safety Major Wright tackled him at the 1-yard line. The ball rolled into the endzone, where Murphy recovered it. Medlock would then kick three more field goals, and by the fourth quarter, the Panthers led 19-7. The tide eventually turned when Panthers punter Brad Nortman shanked a 6-yard punt, and Jay Cutler hit Kellen Davis on a 12-yard touchdown pass with less than seven minutes left in the game. On the first play of the Panthers' next drive, Tim Jennings intercepted Newton and returned the pick 25 yards to regain the lead 20-19, after Cutler's two-point conversion passing attempt was intercepted. Medlock later kicked another field goal to reclaim the lead 22-20 with 2:27 left in the game. Cutler would lead the Bears downfield, and Gould kicked a 41-yard field goal as time expired to give Chicago the victory. The kick was Gould's tenth game-winning field goal, and the first since 2010.
Output: Who is the Panther's kicker?