niryuu/sni-each-converted huggingface dataset:
Context: Coming off their come-from-behind win over the Dolphins, the Broncos traveled to Arrowhead Stadium for an AFC West rematch with the Kansas City Chiefs. The Broncos jumped out to a 14-0 lead on their first two possessions in the first quarter, with quarterback Peyton Manning throwing a pair of touchdown passes a 23-yarder to wide receiver Demaryius Thomas and a 15-yarder to running back C. J. Anderson. A 22-yard field goal by placekicker Connor Barth increased the Broncos' lead to 17-0 early in the second quarter. The scoring play occurred after the Broncos' special teams fooled the Chiefs with a fake punt run by safety David Bruton and a fourth-down conversion by Anderson. The Chiefs got on the scoreboard later in the second quarter, with quarterback Alex Smith connecting on a 20-yard touchdown pass to tight end Anthony Fasano. The Broncos' offense subsequently marched down the field, but had to settle on a 24-yard field goal by Barth just before halftime. The Chiefs' defense forced a fumble off Manning deep in Broncos' territory on the Broncos' first possession of the second half, but had to settle on a 39-yard field goal by placekicker Cairo Santos. Barth added two more field goals a 30-yarder midway through the third quarter and a 33-yarder early in the fourth quarter to increase the Broncos' lead to 26-10. The first field goal came after a DeMarcus Ware interception of Smith on a deflected pass, while the second field goal came after Chiefs' cornerback Marcus Cooper muffed a punt. The Chiefs narrowed the Broncos' lead, with Smith throwing a 12-yard touchdown pass to running back Jamaal Charles. However, Broncos' safety T. J. Ward knocked away a two-point conversion pass from Smith intended for Fasano that would have brought the Chiefs to within a one-score deficit. Barth added one more field goal a 37-yarder midway through the fourth quarter. The Broncos' defense subdued the Chiefs for the remainder of the game. With the win, the Broncos swept the Chiefs for a third consecutive season. Peyton Manning improved his personal record to 11-1 all-time in games against the Chiefs. 
 Question: Which kicker's initial field goal was longer?
Output: cairo santos
Context: Eden Patera is a feature located at 33.6N 348.9E on the planet Mars. 
 Question: Which planet is Eden Patera located?
Output: mars
Context: Using a rat model of L-DOPA-induced dyskinesia (LID), the contributions of dopamine D1 and D2 receptors to axial, limb, and orolingual (ALO) abnormal involuntary movements (AIMs) elicited by L-DOPA were examined. Chronic L-DOPA-treated rats received the D1 receptor antagonist SCH23390 (0.01, 0.1, and 1.0 mg/kg; i.p.), the D2 receptor antagonist Eticlopride (0.01, 0.1, and 1.0 mg/kg; i.p.), a mixture of both antagonists (0.01, 0.1, 1.0 mg/kg each; i.p.), or vehicle 30 min prior to L-DOPA (6 mg/kg; i.p.)+Benserazide (15 mg/kg; i.p.). SCH23390 (0.1 and 1.0 mg/kg) significantly reduced axial and limb AIMs, while the same doses of Eticlopride significantly decreased axial, limb, and orolingual AIMs. Co-administration of SCH23390+Eticlopride significantly reduced axial (0.01, 0.1 and 1.0 mg/kg), limb (0.1 and 1.0 mg/kg), and orolingual (0.1 and 1.0 mg/kg) AIMs. These results indicate the importance of D1 and D2 receptors to LID and further validate the rat AIMs model. 
 Question: Which drug is benserazide usually co-administered with?
Output: l-dopa
Context: In a single year, on average, more than 900,000 earthquakes are recorded and 150,000 of them are strong enough to be felt. Each year about 18 earthquakes are major, with a Richter magnitude of 7.0 to 7.9, and on average one earthquake has a magnitude of 8 to 8.9. Magnitude 9 earthquakes are rare. The United States Geological Survey lists five since 1900 (see Figure 1.1 and Table 1.1). All but the Great Indian Ocean Earthquake of 2004 occurred somewhere around the Pacific Ocean basin. Location Valdivia, Chile Prince William Sound, Alaska Great Indian Ocean Earthquake Kamchatka, Alaska Tohoku, Japan Year 1960 1964 2004 1952 2011 Magnitude 9.5 9.2 9.1 9.0 9.0 The 1964 Good Friday Earthquake cen- tered in Prince William Sound, Alaska re- leased the second most amount of energy of any earthquake in recorded history. Nearly 95% of all earthquakes take place along one of the three types of plate boundaries. About 80% of all earthquakes strike around the Pacific Ocean basin because it is lined with convergent and transform boundaries (Figure 1.2). About 15% take place in the Mediterranean-Asiatic Belt, where convergence is causing the Indian Plate to run into the Eurasian Plate. The remaining 5% are scattered around other plate boundaries or are intraplate earthquakes. Earthquake epicenters for magnitude 8.0 and greater events since 1900. The earthquake depth shows that most large quakes are shallow focus, but some sub- ducted plates cause deep focus quakes. 
 Question: the location where most earthquakes strike is
Output: pacific ocean basin
Context: Back at home, the Dallas Cowboys traveled to Nashville to face off against the Titans. The Titans started their rookie quarterback Vince Young after veteran Kerry Collins produced dismal results after the first 3 games of the season. The Titans were able to score with a field goal on their opening drive making it the first time this season that they were able to score in the first quarter. The Titans were held to two field goals in the first half while the Cowboys had a lead at halftime with two 13-yard TD passes from Drew Bledsoe to WR Terry Glenn to put them up 14-6. The Cowboys continued to drive up the score during the 3rd quarter with a 5-yard touchdown run by RB Julius Jones. During this play Titans' DT Albert Haynesworth stepped on the face of Cowboys center Andre Gurode. Haynesworth was flagged for Unsportsmanlike Conduct and ejected from the game. He protested his ejection by taking off his helmet and throwing it on the ground. He was then flagged again with another Unsportsmanlike Conduct penalty. Gurode left the field with an ice pack to his face and required stitched above his left eye. He did not return to the field. Head Coach Jeff Fisher as well as Haynesworth later apologized for his actions. Vince Young connected for his second touchdown of the year to TE Ben Troupe. During the 4th quarter, the Cowboys scored on a field goal by Mike Vanderjagt. LB Brady James intercepted Vince Young's pass intended for Ben Troupe and returned it for a touchdown. The Cowboys sealed the win with a 7-yard TD run by Tyson Thompson with a final score of 45 to 14. The Cowboys moved to 2 and 1 while the Titans continued to losing streak dropping to 0-4. 
 Question: From what distance did Terry Glenn catch two touchdown passes?
Output: 13-yard
Context: In the county, the population was spread out with 23.5% under the age of 18, 7.8% from 18 to 24, 28.5% from 25 to 44, 25.9% from 45 to 64, and 14.2% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 93.8 males. For every 100 females age 18 and over, there were 90.5 males. 
 Question: What age group had the smallest percent of population?
Output: 18 to 24
Context: Acute lung injury is a life-threatening condition characterized by surfactant dysfunction and raised secretory phospholipase A2 (sPLA2) activity. Varespladib is a sPLA2 inhibitor shown to be effective in animal models of acute lung injury. We aimed at investigating the effect of co-administration of surfactant and varespladib on sPLA2 activity. Alveolar macrophages were cultured and stimulated with lipopolysaccharide and then treated with either varespladib, surfactant, varespladib followed by surfactant or nothing. sPLA2 activity, free fatty acids, tumour necrosis factor- (TNF-) and protein concentrations were measured in culture supernatants. Treatment with varespladib (p=0.019) and varespladib + surfactant (p=0.013), reduced the enzyme activity by approximately 15% from the basal level measured in the untreated cultures. Surfactant, varespladib and varespladib + surfactant, respectively decreased free fatty acids by -45% (p=0.045), - 62% (p=0.009) and -48% (p=0.015), from the baseline concentration of the untreated cultures. Varespladib and poractant- co-administration reduces sPLA2 activity and free fatty acids release in cultured rat alveolar macrophages, although a clear drug synergy was not evident. Since co-administration may be useful to reduce inflammation and surfactant inactivation in acute lung injury, further in vivo studies are warranted to verify its clinical usefulness. 
 Question: Which enzyme is inhibited by Varespladib?
Output: secretory phospholipase a2
Context: Human erythrocyte spectrin is an antiparallel heterodimer comprised of a 280 kDa alpha subunit and a 246 kDa beta subunit which further associates into tetramers in the red cell membrane cytoskeleton. Lateral association of the flexible rodlike monomers involves a multiple-step process that is initiated by a high affinity association near the actin-binding end of the molecule (dimer nucleation site). In this study, recombinant alpha and beta proteins comprising two or four "spectrin type" motifs with and without adjacent, terminal nonhomologous domains were evaluated for their relative contributions to dimer initiation, and the thermodynamic properties of these heterodimer complexes were measured. Sedimentation equilibrium studies showed that in the absence of the heterologous subunit, individual recombinant proteins formed weak homodimers (K(d) > 0.3 mM). When 2-motif (alpha20-21 and beta1-2) and 4-motif (alpha18-21 and beta1-4) recombinants lacking the terminal nonhomologous domains were paired with the complementary protein, high affinity heterodimers were formed in sedimentation equilibrium analysis. Both the alpha20-21/beta1-2 complex and the alpha20-21EF/betaABD1-2 complex showed stoichiometric binding with similar binding affinities (K(d) approximately 10 nM) using isothermal titration calorimetry. The alpha20-21/beta1-2 complex showed an enthalpy of -10 kcal/mol, while the alpha20-21EF/betaABD1-2 complex showed an enthalpy of -13 kcal/mol. Pull-down assays using alpha spectrin GST fusion proteins showed strong associations between all heterodimer complexes in physiological buffer, but all heterodimer complexes were destabilized by the presence of Triton X-100 and other detergents. Complexes lacking the nonhomologous domains were destabilized to a greater extent than complexes that included the nonhomologous domains. The detergent effect appears to be responsible for the apparent essential role of the nonhomologous domains in prior reports. Taken together, our results indicate that the terminal nonhomologous domains do not contribute to dimer initiation nor are they required for formation of high affinity spectrin heterodimers in physiological buffers. 
 Question: Alpha-spectrin and beta-spectrin subunits form parallel or antiparallel heterodimers?
Output: antiparallel
Context: Joseph Jean-Pierre Marc Garneau, C.C., CD, Ph.D., F.C.A.S.I., PC, MP (born February 23, 1949) is a Canadian politician and the Minister of Transport in the Government of Canada. 
 Question: What is the position of Marc Garneau?
Output: minister of transport
Context: Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light. 
 Question: Who's parents were in an auto wreck?
Output: pud's
Context: Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light. 
 Question: Who's parents were in an auto wreck?
Output: pud
Context: Transportes Aereos Guatemaltecos (TAG) is a private passenger and cargo airline based at Guatemala La Aurora International Airport. 
 Question: What is the name of the airport associated with Transportes Aereos Guatemaltecos?
Output: la aurora international airport
Context: An 11-day embryonic Swiss Webster/NIH mouse cDNA library was screened with a partial murine selenoprotein P cDNA probe and a murine selenoprotein-P-type cDNA clone of 2075 bp length was obtained. The clone contained a 5'-leader sequence of 132 bp length, the selenoprotein P coding frame, and 803 base pairs in the 3' untranslated region. Alignment and RNA folding studies revealed the presence of two well conserved selenocysteine inserting motifs in the 3' flanking region. The deduced polypeptide sequence comprises 380 residues including ten selenocysteines. Identical amino acid residues in homologous positions are 86%, 71%, and 64% when compared to the previously reported selenoprotein P sequences of rat, man, and cattle, respectively. The comparatively low similarity between the selenoprotein P sequences reported so far leaves open the question whether they belong to the same molecular clade. 
 Question: Which is the human selenoprotein that contains several Se-Cys residues?
Output: selenoprotein-p
Context: An 11-day embryonic Swiss Webster/NIH mouse cDNA library was screened with a partial murine selenoprotein P cDNA probe and a murine selenoprotein-P-type cDNA clone of 2075 bp length was obtained. The clone contained a 5'-leader sequence of 132 bp length, the selenoprotein P coding frame, and 803 base pairs in the 3' untranslated region. Alignment and RNA folding studies revealed the presence of two well conserved selenocysteine inserting motifs in the 3' flanking region. The deduced polypeptide sequence comprises 380 residues including ten selenocysteines. Identical amino acid residues in homologous positions are 86%, 71%, and 64% when compared to the previously reported selenoprotein P sequences of rat, man, and cattle, respectively. The comparatively low similarity between the selenoprotein P sequences reported so far leaves open the question whether they belong to the same molecular clade. 
 Question: Which is the human selenoprotein that contains several Se-Cys residues?
Output: selenoprotein p
Context: Cyclosporine mediates its immunosuppressive effect by preventing the synthesis of lymphokine mRNA during the process of T lymphocyte activation. Although the detailed molecular mechanism by which CsA achieves this effect is unknown, two proteins have been identified as putative intracellular CsA-receptor proteins. One of these, calmodulin, is an important Ca++-binding protein and enzyme cofactor and the other, cyclophilin, is a novel protein that is reported to have protein kinase activity. In this study the CsA-binding capacity of both these proteins has been assessed using CsA-coated ELISA plates and CsA-affinity gel matrices. CsA binding was shown by cyclophilin whereas no CsA-calmodulin binding could be detected under identical conditions. However, it was not possible to demonstrate any cyclophilin-associated protein kinase activity. Jurkat cells were probed for the presence of CsA-binding proteins using the CsA-affinity gel matrix; a 17 KD protein, most probably cyclophilin, was identified as the major CsA-binding protein. In addition, a previously unidentified CsA-binding 45 KD phosphoprotein was precipitated from 32P-labeled Jurkat cells. These results would support cyclophilin as the major, if not only, intracellular receptor protein for CsA. However, the relationship between binding of CsA to cyclophilin and/or the 45 KD phosphoprotein and the immunosuppressive effects of CsA is still unknown. 
 Question: Which is the receptor for the immunosuppressive drug cyclosporin A (CsA)?
Output: cyclophilin
Context: Rolland-Pilain was a French car maker formally established on 4 November 1905 at 95, rue Victor-Hugo in Tours by Francois Rolland and Emile Pilain. 
 Question: Which year witnessed the formation of Rolland-Pilain?
Output: november 1905
Context: The Lithuanian Civil War of 1432-1438 was a conflict over the succession to the throne of the Grand Duchy of Lithuania, after Vytautas the Great died in 1430 without leaving an heir. The war was fought on the one side by Svitrigaila, allied with the Teutonic Knights, and on the other by Sigismund Kestutaitis, backed by the Kingdom of Poland. The war threatened to sever the Union of Krewo, the personal union between Poland and Lithuania. Svitrigaila's alliance with the Grand Master of the Teutonic Order, Paul von Rusdorf, launched the Polish-Teutonic War but failed to secure victory for Svitrigaila. When Sigismund captured power in Lithuania by staging a coup in 1432, Lithuania split into two opposing camps, and there began three years of devastating hostilities. To prevent the Knights from continuing their support of Svitrigaila, Poland backed a Hussite invasion of Prussia in 1433. The war ended in a decisive defeat for Svitrigaila and his ally, the Livonian branch of the Teutonic Knights, at the Battle of Pabaiskas in September 1435. Svitrigaila eventually surrendered in 1437; Sigismund Kestutaitis ruled Lithuania for only eight years before he was assassinated in 1440. 
 Question: What event threatened the Union of Krewo?
Output: lithuanian civil war of 1432-1438
Context: The PLZ-45 or Type 88 is a 155 mm self-propelled howitzer designed by Su Zhezi of 674 Factory, and developed by Norinco, 123 Factory (Heilongjiang Hua'an Industry Group Company), 127 Factory (Tsitsihar Heping Machine Shop), 674 Factory (Harbin First Machine Manufacture Limited Company) and Beijing Institute of Technology in the early 1990s for the export market. 
 Question: Which company manufactured PLZ-45?
Output: norinco
Context: A study was carried out on 200 patients of ages 20-40 years suffering from acute viral hepatitis. Sera were tested for markers of hepatitis B (HBsAg, and IgM anti-HBc) and hepatitis A (IgM-anti-HAV) by the ELISA technique. Sera negative for the markers of both viruses: Hepatitis A (HAV) and Hepatitis B (HBV) were subsequently tested for IGM Heterophil antibodies against Epstein-Barr virus (EBV) by the Monospot slide test to diagnose acute infectious mononucleosis and tested for anti-CMV (IgM) by ELISA technique for the diagnosis of acute Cytomegalovirus (CMV) infection. Non-A, non-B hepatitis (NANB) was diagnosed by exclusion. The results of the study showed that 133 (66.5%) patients had evidence of HBV infection, while only 9(4.5%) were diagnosed as HAV infection. EBV and CMV were the possible etiological agents of acute viral hepatitis in (3.5%) and 1%) respectively. Accordingly the Non-A, non-B hepatitis in this study amounts to (24.5%) of the acute viral hepatitis. 
 Question: Which virus can be diagnosed with the monospot test?
Output: epstein-barr virus
Context: Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine formulation. Throughout its development, increasingly more effective adjuvants have been key in improving the potency of the vaccine. RTS,S-based vaccine formulations have been demonstrated to be safe, well tolerated, immunogenic, and to confer partial efficacy in both malaria-naive and -experienced adults as well as children. Further research to optimize and improve vaccine efficacy is ongoing. 
 Question: RTS S AS01 vaccine was developed to prevent which disease?
Output: malaria
Context: Selenoprotein S (SelS) is a 189 amino acid trans-membrane protein that plays an important yet undefined role in the unfolded protein response. It has been proposed that SelS may function as a reductase, with the penultimate selenocysteine (Sec(188)) residue participating in a selenosulfide bond with cysteine (Cys(174)). Cotranslational incorporation of Sec into SelS depends on the recoding of the UGA codon, which requires a Selenocysteine Insertion Sequence (SECIS) element in the 3'UTR of the transcript. Here we identify multiple mechanisms that regulate the expression of SelS. The human SelS gene encodes two transcripts (variants 1 and 2), which differ in their 3'UTR sequences due to an alternative splicing event that removes the SECIS element from the variant 1 transcript. Both transcripts are widely expressed in human cell lines, with the SECIS-containing variant 2 mRNA being more abundant. In vitro experiments demonstrate that the variant 1 3'UTR does not allow readthrough of the UGA/Sec codon. Thus, this transcript would produce a truncated protein that does not contain Sec and cannot make the selenosulfide bond. While the variant 2 3'UTR does support Sec insertion, its activity is weak. Bioinformatic analysis revealed two highly conserved stem-loop structures, one in the proximal part of the variant 2 3'UTR and the other immediately downstream of the SECIS element. The proximal stem-loop promotes Sec insertion in the native context but not when positioned far from the UGA/Sec codon in a heterologous mRNA. In contrast, the 140 nucleotides downstream of the SECIS element inhibit Sec insertion. We also show that endogenous SelS is enriched at perinuclear speckles, in addition to its known localization in the endoplasmic reticulum. Our results suggest the expression of endogenous SelS is more complex than previously appreciated, which has implications for past and future studies on the function of this protein. 
 Question: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Output: secis
Context: Periodic limb movement disorder (PLMD) is one of the commonest neurological disorders and causes significant disability, if left untreated. However, it is rarely diagnosed in clinical practice, probably due to lack of awareness and/or lack of necessary diagnostic facilities. Restless leg syndrome (RLS), aging, pregnancy, uraemia, iron deficiency, polyneuropathy are some of the common causes of secondary PLMD. Clinical presentation, polysomnographic findings and management of six patients of PLMD have been discussed in this report. 
 Question: Which deficiency is the cause of restless leg syndrome?
Output: iron
Context: The Rebellion was the career highlight for both leaders; Cumberland resigned from the Army in 1757 and died of a stroke in 1765. Charles was initially treated as a hero on his return to Paris but the Stuarts were once again barred from France by the 1748 Treaty of Aix-la-Chapelle. Henry Stuart's entry into the Catholic Church in June 1747 was seen as tacit acceptance the Jacobites were finished and Charles never forgave him. He continued attempts to reignite the cause, including a secret visit to London in 1750 but habitual heavy drinking made him argumentative and hard to work with. In 1759, he met French Chief Minister de Choiseul to discuss another invasion attempt but Choiseul dismissed him as incapable through drink. When his father James died in 1766, Pope Clement XIII refused to recognise him as Charles III, despite the strong objections of his brother Henry. Charles never visited Britain again and died in Rome in January 1788, a disappointed and embittered man. 
 Question: How was James related to Pope Clement XIII?
Output: his father
Context: Goodreads. com is a website for book lovers everywhere. If you love to read, and if you love social networking, you should check out Goodreads. The website marries social networking and books in such a way as makes your friends' reading progress easy to follow and makes it simpler than ever to find your next reading material. Goodreads is a social network for readers. Like Facebook or Twitter, it allows you to share information. Unlike most popular social networks, Goodreads also allows you to show your friends your progress on the book you are reading and to write reviews for everything you've ever read. You can see and comment on your friends' reading progress. Goodreads is simple to use. When you sign up for an account, you will be able to find your friends by their email addresses or other social network accounts. Once you have some friends, every time you log in, you will see a timeline of their updates. You can see when they've added a book to a list, or when they've finished or reviewed a book. As soon as you have an account, you can also start looking for books you've read or that you want to read and added them to your lists. Once you finish reading a book, you can go to the book page and review it by giving it any number out of five stars. If you wish to write a longer review, you can do that, too. If you have ever finished a book and needed a recommendation for what to read next, Goodreads has the answer. Finding your next book has never been easier. Now, not only can you search for individual books you know you want to read and add them to your "to read" list, but you can also easily see what your friends have recently read. When you search through your friends' reviews, you can also see who likes what books, making your selection process even easier. Adding books to your "to read" list can help you keep track of what you want to read next, and seeing what books your friends enjoy - or don't enjoy- can help you better your list of books to read next. Like all good social networks, Goodreads has apps for mobile phones and ways to connect to other social networks. You can get Goodreads for iphone and Android by downloading them from the App Store or Andorid Market. You can also connect your Facebook and Twitter accounts so all of your networks know what you're reading. Furthermore, you can connect your Amazon Kindle to automatically update your progress on your e-books. Last but not least , you can set up Goodreads to auto- publish book reviews to your Wordpress or blog. Sharing your favorite books has never been easier . If you want to create a web space for your own book club, you can do that easily; just start a new group on Goodreads and update the page to show what books you're reading. You can also create events to easily share with members where and when book club meetings and author readings are taking place. Goodreads. com is young, but we will do our best to attract more people and we hope you can use it and give us your advice. 
 Question: Who is the potential readers of the passage ?
Output: book lovers.
Context: While performing on her Intimate and Live concert tour in Australia, Minogue confirmed that she would release ''Cowboy Style'' as the fourth single in Australia and New Zealand by Mushroom Records. 
 Question: Which was the record label for Cowboy Style?
Output: mushroom records
Context: With Constantine's death in 337, Constans and his two brothers, Constantine II and Constantius II, divided the Roman world between themselves and disposed of virtually all relatives who could possibly have a claim to the throne. 
 Question: What is Constans's brothers name?
Output: constantius ii
Context: Armored Fist 3 is a tank simulation video game developed and published by NovaLogic, released on October 12, 1999. 
 Question: Who worked on Armored Fist 3?
Output: novalogic
Context: Genome-wide association studies have identified strong associations between the risk of developing Parkinson's disease (PD) and polymorphisms in the genes encoding -synuclein and the microtubule-associated protein tau. However, the contribution of tau and its phosphorylated form (p-tau) to -synuclein-induced pathology and neuronal dysfunction remains controversial. We have assessed the effects of NAP (davunetide), an eight-amino acid peptide that decreases tau hyperphosphorylation, in mice overexpressing wild-type human -synuclein (Thy1-aSyn mice), a model that recapitulates aspects of PD. We found that the p-tau/tau level increased in a subcortical tissue block that includes the striatum and brain stem, and in the cerebellum of the Thy1-aSyn mice compared to nontransgenic controls. Intermittent intranasal NAP administration at 2 g/mouse per day, 5 days a week, for 24 weeks, starting at 4 weeks of age, significantly decreased the ratio of p-tau/tau levels in the subcortical region while a higher dose of 15 g/mouse per day induced a decrease in p-tau/tau levels in the cerebellum. Both NAP doses reduced hyperactivity, improved habituation to a novel environment, and reduced olfactory deficits in the Thy1-aSyn mice, but neither dose improved the severe deficits of motor coordination observed on the challenging beam and pole, contrasting with previous data obtained with continuous daily administration of the drug. The data reveal novel effects of NAP on brain p-tau/tau and behavioral outcomes in this model of synucleinopathy and suggest that sustained exposure to NAP may be necessary for maximal benefits. 
 Question: How many amino acids does davunetide consist of?
Output: eight
Context: Ulysses Colles is an official name for conical edifices associated with flows in Ulysses Fossae in the Tharsis quadrangle of Mars. 
 Question: On what moon or planet can Ulysses Colles be found?
Output: mars
Context: Newtons third law of motion explains how Jerod starts his skateboard moving. This law states that every action has an equal and opposite reaction. This means that forces always act in pairs. First an action occursJerod pushes against the ground with his foot. Then a reaction occursJerod moves forward on his skateboard. The reaction is always equal in strength to the action but in the opposite direction. Q: If Jerod pushes against the ground with greater force, how will this affect his forward motion? A: His action force will be greater, so the reaction force will be greater as well. Jerod will be pushed forward with more force, and this will make him go faster and farther. The forces involved in actions and reactions can be represented with arrows. The way an arrow points shows the direction of the force, and the size of the arrow represents the strength of the force. Look at the skateboarders in the Figure 1.1. In the top row, the arrows represent the forces with which the skateboarders push against each other. This is the action. In the bottom row, the arrows represent the forces with which the skateboarders move apart. This is the reaction. Compare the top and bottom arrows. They point in different directions, but they are the same size. This shows that the reaction forces are equal and opposite to the action forces. Because action and reaction forces are equal and opposite, you might think they would cancel out, as balanced forces do. But you would be wrong. Balanced forces are equal and opposite forces that act on the same object. Thats why they cancel out. Action-reaction forces are equal and opposite forces that act on different objects, so they dont cancel out. In fact, they often result in motion. Think about Jerod again. He applies force with his foot to the ground, whereas the ground applies force to Jerod and the skateboard, causing them to move forward. Q: Actions and reactions occur all the time. Can you think of an example in your daily life? A: Heres one example. If you lean on something like a wall or your locker, you are applying force to it. The wall or locker applies an equal and opposite force to you. If it didnt, you would go right through it or else it would tip over. 
 Question: the lift off of a rocket is a(n)
Output: reaction force.
Context: Stories in Boxes: Britain performing artist Bobby Baker will present Box Story to conclude the UK performing Arts Festival. Her performances cover various aspects of life: including health, shopping, and educating children. She explores these themes with originality and "outside the square". Time: 7:30 pm, December 3-5 Place: North Theater, Beibingmasi Lane, Jiaodaokou, Dongcheng District Tel: 8602-4898 Elvis Story: Le Caoitole De Quebee will bring its production The Elvis Storyto Beijing audiences this month. This remarkable musical production relates the best moments of Elvis Preeley's life and his career. The show is a musical reconstitution of the life of a singer who revolutionized American popular music and become the most famous rock star of the 20th century. Time: 7:30 pm, November 25-28 Place: Poly Theater, Dongsishitiao Tel: 6506-5343, 6413-1321 Soldier's musical: A Soldier's Diary, a Chinese musical describing the life of contemporary soldiers in China, is to be staged for 12 performances by the Song and Dance Essembles of the Political of the Chinese People Liberation Army . Time: 7:30 pm, November 29-December15 Place: China Theatre, Xisanhuan Beilu, Handian District Tel: 6843-0560 Social tolerance: The Italian opera Pagliacci, by Ruggero Leoneavallo ( 1856--1919), is to premiere , performed by Chinese opera singers from China's Central Opera Theatre. A violent opera exploring the limits of social tolerance, the opera premiered in 1892 and gained popularity throughout Europe and America. Within two years, it had been translated into all major European languages including Swedish, Serbo-Croatian and Hebrew. Leoneavallo was a prolific writer, yet none of his other works ever matched the popularity of this opera. Chinese vocal artists include Huang Yuefeng, Wang Feng, Sun Xiewei, Gao Lei and Shen Na, Li Wei is to conduct.. Time: 7:30 pm, November 27 Place: Peking University Concert Hall, Peking University Tel: 6275-1278, 6551-4787 
 Question: If Peter is a soldier, which place perhaps would he like to go on November 29?
Output: china theatre
Context: The centromeric regions of all Saccharomyces cerevisiae chromosomes are found in early replicating domains, a property conserved among centromeres in fungi and some higher eukaryotes. Surprisingly, little is known about the biological significance or the mechanism of early centromere replication; however, the extensive conservation suggests that it is important for chromosome maintenance. Do centromeres ensure their early replication by promoting early activation of nearby origins, or have they migrated over evolutionary time to reside in early replicating regions? In Candida albicans, a neocentromere contains an early firing origin, supporting the first hypothesis but not addressing whether the new origin is intrinsically early firing or whether the centromere influences replication time. Because the activation time of individual origins is not an intrinsic property of S. cerevisiae origins, but is influenced by surrounding sequences, we sought to test the hypothesis that centromeres influence replication time by moving a centromere to a late replication domain. We used a modified Meselson-Stahl density transfer assay to measure the kinetics of replication for regions of chromosome XIV in which either the functional centromere or a point-mutated version had been moved near origins that reside in a late replication region. We show that a functional centromere acts in cis over a distance as great as 19 kb to advance the initiation time of origins. Our results constitute a direct link between establishment of the kinetochore and the replication initiation machinery, and suggest that the proposed higher-order structure of the pericentric chromatin influences replication initiation. 
 Question: Do origins of replication close to yeast centromeres fire early or late?
Output: early
Context: Christianson syndrome is an X-linked mental retardation syndrome characterized by microcephaly, impaired ocular movement, severe global developmental delay, hypotonia which progresses to spasticity, and early onset seizures of variable types. Gilfillan et al.2008] reported mutations in SLC9A6, the gene encoding the sodium/hydrogen exchanger NHE6, in the family first reported and in three others. They also noted the clinical similarities to Angelman syndrome and found cerebellar atrophy on MRI and elevated glutamate/glutamine in the basal ganglia on MRS. Here we report on nonsense mutations in two additional families. The natural history is detailed in childhood and adult life, the similarities to Angelman syndrome confirmed, and the MRI/MRS findings documented in three affected boys. 
 Question: Mutation of which gene is implicated in the Christianson syndrome?
Output: slc9a6
Context: The general Chinese history texts on the Ming Dynasty, including the Mingdai Shi and the Mingshi, briefly mention Cao Qin's failed coup of 1461. Cao Qin's coup and the events leading up to it were covered in Gao Dai's Hong you lu of 1573, Jiao Hong's Guochao Xianzheng lu of 1594-1616, the Huang Ming shi gai of 1632 and the Mingshi jishi benmo of 1658. Li Xian also wrote about Cao Jixiang's career in his "Cao Jixiang zhi bian," featured in the Huang Ming mingchen jingji lu that was edited by Huang Xun in 1551. 
 Question: What happened second: Jiao Hong's Guochao Xianzheng lu or Huang Ming shi gai?
Output: huang ming shi gai
Context: The War of the Spanish Succession was a European conflict of the early 18th century, triggered by the death of the childless Charles II of Spain in November 1700. His closest heirs were members of the Austrian Habsburg and French Bourbon families; acquisition of an undivided Spanish Empire or Monarchy by either threatened the European balance of power. Charles left his throne to Louis XIV's grandson Philip who was proclaimed King of Spain on 16 November 1700. Disputes over the separation of the Spanish and French crowns, division of territories and commercial rights led to war in 1701 between the Bourbons of France and Spain and the Grand Alliance, whose candidate was Archduke Charles, younger son of Habsburg Emperor Leopold. By 1710, fighting was deadlocked; Allied victories in Italy and the Low Countries had driven the French back to their borders but they could not achieve a decisive breakthrough while Philip was secure in Spain. When Archduke Charles succeeded his brother Joseph I as Emperor in 1711, Britain effectively withdrew, forcing its Allies to make peace and leading to the 1713 Treaty of Utrecht, followed in 1714 with Rastatt and Baden. Philip was confirmed as King of Spain and renounced the French throne; Spain retained the bulk of its pre-war territories outside Europe with their European territories divided between Austria, Britain and Savoy. Longer term impacts included Britain's emergence as the leading maritime and commercial power, the beginning of the decline of the Dutch Republic, the creation of a centralised Spanish state and the acceleration of the break-up of the Holy Roman Empire. 
 Question: What was King Philip of Spain's relationship to Louis XIV?
Output: grandson
Context: Transmembrane protein 131-like(TMEM131L protein), alternatively named uncharacterized protein KIAA0922 (KIAA0922 protein), is an integral transmembrane protein encoded by the human gene KIAA0922 that is significantly conserved in eukaryotes, at least through protists. 
 Question: Which species has the KIAA0922 gene?
Output: human
Context: The Seahawks began their 2008 campaign on the road against the Buffalo Bills. In the first quarter, Seattle trailed early as Bills RB Marshawn Lynch got a 21-yard TD run. In the second quarter, the Seahawks continued to struggle as WR/PR Roscoe Parrish returned a punt 63 yards for a touchdown. Seattle responded with QB Matt Hasselbeck completing a 20-yard TD pass to WR Nate Burleson. Buffalo closed out the half with kicker Rian Lindell getting a 35-yard and a 38-yard field goal. In the third quarter, the Seahawks replied with kicker Olindo Mare nailing a 45-yard field goal. However, the Bills pulled a trick play on Seattle. Appearing to go for a 32-yard field goal, Buffalo's holder (punter Brian Moorman) instead threw a 19-yard TD pass to DE Ryan Denney. The Bills pulled away with QB Trent Edwards completing a 30-yard TD pass to TE Robert Royal. 
 Question: Who kicked the longest field goal of the game?
Output: olindo mare
Context: Patients with multiple myeloma (MM) experience pathologic fractures, bone pain, hypercalcemia, neurologic symptoms, and renal insufficiency with substantial morbidity and mortality. Bisphosphonates have been used successfully for the management of MM-related bone disease. Increased incidence of osteonecrosis of the jaw has been observed in patients with cancer receiving bisphosphonate therapy. Recent advances in the pathobiology of MM-related bone disease and other cancer-related bone metastases have led to the identification of novel therapeutic targets, such as receptor activator of nuclear factor-kappaB (RANK); its ligand (RANKL); and a decoy receptor, osteoprotegerin, for the development of potential targeted agents. Initials studies have demonstrated that targeting RANK/ RANKL signaling with the fully human monoclonal antibody denosumab prevented skeletal complications in patients with MM and other cancers with bone metastases. Ongoing studies evaluating the clinical utility of denosumab in cancer- related bone destruction have been discussed. In addition, several potential targets, such as macrophage inflammatory protein-1alpha, chemokine receptors 1 and 5, interleukin-3, and Wnt signaling, are b riefly described. 
 Question: To the ligand of which receptors does Denosumab (Prolia) bind?
Output: rankl
Context: Perhaps you have heard a lot about the Internet, but what is it, do you know? The Internet is a network. It uses the telephone to join millions of computers together around the world. Maybe that doesn't sound very interesting. But when you're joined to the Internet, there are lots and lots of things you can do. You can send E-mails to your friends, and they can get them in a few seconds. You can also do with all kinds of information on the World Wide Web (www). There are many different kinds of computers now. They all can be joined to the Internet. Most of them are small machines sitting on people's desks at home, but there are still many others in schools, offices or large companies. These computers are owned by people and companies, but no one really owns the Internet itself. There are lots of places for you to go into the Internet. For example, your school may have the Internet. You can use it during lessons or free time. Libraries often have computers joined to the Internet. You are welcome to use it at any time. Thanks to the Internet, the world is becoming smaller and smaller. It is possible for you to work at home with a computer in front, getting and sending the information you need. You can buy or sell whatever you want on the Internet. But do you know 98% of the information on the Internet is in English? So what will English be like tomorrow? 
 Question: Who is the owner of the Internet?
Output: no one.