niryuu/sni-each-converted huggingface dataset:
Context: As of the 2010 United States Census, there were 1,951,269 people, 715,365 households, and 467,916 families residing in the county. The population density was . There were 840,343 housing units at an average density of . The racial makeup of the county was 60.9% white, 10.5% black or African American, 8.7% Asian, 0.7% Pacific islander, 0.7% American Indian, 13.5% from other races, and 5.1% from two or more races. Those of Hispanic or Latino origin made up 29.1% of the population. In terms of ancestry, 11.7% were Germans, 9.1% were Irish people, 7.6% were English people, 6.3% were Italians, and 2.7% were Americans. 
 Question: Were the more families or households residing in the county?
Output: households
Context: The Queen's Royal Irish Hussars, abbreviated as QRIH, was a cavalry regiment of the British Army formed from the amalgamation of the 4th Queen's Own Hussars and the 8th King's Royal Irish Hussars in Hohne, West Germany in 1958. 
 Question: What military branch did Queen's Royal Irish Hussars serve?
Output: british army
Context: Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we determined effects of the SGLT2 inhibitor empagliflozin (300 mg/kg of diet for 15 wk; corresponding to 60-80 mgkg(-1)day(-1)) in type 1 diabetic Akita mice that, opposite to streptozotocin-diabetes, upregulate renal SGLT2 expression. Akita diabetes, empagliflozin, and Akita + empagliflozin similarly increased renal membrane SGLT2 expression (by 38-56%) and reduced the expression of SGLT1 (by 33-37%) vs. vehicle-treated wild-type controls (WT). The diabetes-induced changes in SGLT2/SGLT1 protein expression are expected to enhance the BG-lowering potential of SGLT2 inhibition, and empagliflozin strongly lowered BG in Akita (means of 187-237 vs. 517-535 mg/dl in vehicle group; 100-140 mg/dl in WT). Empagliflozin modestly reduced GFR in WT (250 vs. 306 l/min) and completely prevented the diabetes-induced increase in glomerular filtration rate (GFR) (255 vs. 397 l/min). Empagliflozin attenuated increases in kidney weight and urinary albumin/creatinine ratio in Akita in proportion to hyperglycemia. Empagliflozin did not increase urinary glucose/creatinine ratios in Akita, indicating the reduction in filtered glucose balanced the inhibition of glucose reabsorption. Empagliflozin attenuated/prevented the increase in systolic blood pressure, glomerular size, and molecular markers of kidney growth, inflammation, and gluconeogenesis in Akita. We propose that SGLT2 inhibition can lower GFR independent of reducing BG (consistent with the tubular hypothesis of diabetic glomerular hyperfiltration), while attenuation of albuminuria, kidney growth, and inflammation in the early diabetic kidney may mostly be secondary to lower BG. 
 Question: Which protein does empagliflozin inhibit?
Output: sglt2
Context: A dentist's office may not be everyone's idea of a perfect holiday destination.But a growing number of Europeans are travelling abroad for medical treatment to save money,or maybe to combine a visit to the doctor with some sightseeing,creating a potential but fastgrowing market for traditional tour operators. "It was simply cheaper for me to go to a dentist in Hungary," said a 42yearold physical therapist from Berlin.He chose the clinic near Budapest from an Internet advertisement,attracted by hundreds of euros in savings compared with the same treatment in Germany.He was happy to find when he got there that the clinic was clean,the staff qualified and the work thorough. People travel abroad for medical treatment for various reasons:it's cheaper,they face a long wait at home,or the treatment they want is not available in their own country.The Britishbased Medical Tourist Company refers about 100 patients a year to hospitals in India for treatments.And Chief Executive Premhar Shah reports rapid growth in demand from customers in Africa,where it can be harder to find wellequipped medical facilities for complex surgeries. Some patients who have immigrated may prefer to return to be close to their families when they undergo surgery."People will want to take the opportunity to seek treatment in places where they have relatives who might be able to look after them.I'm seeing that especially with younger people from eastern Europe," said a professor at the University of Oxford. For some,there is the attraction of free treatment abroad.British lawmakers have called for tighter checks on patients arriving for treatment,out of concerns that foreign citizens are travelling to Britain to take advantage of the free service. The global medical tourism market is believed to be worth $40 billion to $60 billion and growing at about 20 percent per year. 
 Question: What does the article mainly talk about?
Output: medical tourism.
Context: In the county, the population was spread out with 23.20% under the age of 18, 7.70% from 18 to 24, 27.00% from 25 to 44, 28.00% from 45 to 64, and 14.10% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 97.00 males. For every 100 females age 18 and over, there were 96.40 males. 
 Question: Which age group had the third most people?
Output: under the age of 18
Context: The Bacillus anthracis toxin genes, cya, lef, and pag, can be viewed as a regulon, in which transcription of all three genes is activated in trans by the same regulatory gene, atxA, in response to the same signal, CO2. In atxA+ strains, toxin gene expression is increased 5- to 20-fold in cells grown in 5% CO2 relative to cells grown in air. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Here, we used two independent techniques to obtain evidence for additional CO2-induced atxA-regulated genes. First, total protein preparations from atxA4+ and atxA isolates grown in 5% CO2 and in air were examined by two-dimensional electrophoresis. Comparison of the resulting protein patterns indicated that synthesis of non-toxin proteins is influenced by growth in elevated CO2 and the toxin gene regulator, atxA. Second, we generated random transcriptional lacZ fusions in B. anthracis with transposon Tn917-LTV3. Transposon-insertion libraries were screened for mutants expressing CO2-enhanced atxA-dependent beta-galactosidase activity. DNA sequence analysis of transposon insertion sites in 17 mutants carrying CO2- and atxA-regulated fusions revealed 10 mutants carrying independent insertions on the 185-kb toxin plasmid pXO1 which did not map to the toxin genes. The tcr-lacZ fusion mutants (tcr for toxin coregulated) were Tox+, indicating that these genes may not be involved in anthrax toxin gene activation. Our data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins. 
 Question: Which metabolite activates AtxA?
Output: bicarbonate
Context: The Bacillus anthracis toxin genes, cya, lef, and pag, can be viewed as a regulon, in which transcription of all three genes is activated in trans by the same regulatory gene, atxA, in response to the same signal, CO2. In atxA+ strains, toxin gene expression is increased 5- to 20-fold in cells grown in 5% CO2 relative to cells grown in air. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Here, we used two independent techniques to obtain evidence for additional CO2-induced atxA-regulated genes. First, total protein preparations from atxA4+ and atxA isolates grown in 5% CO2 and in air were examined by two-dimensional electrophoresis. Comparison of the resulting protein patterns indicated that synthesis of non-toxin proteins is influenced by growth in elevated CO2 and the toxin gene regulator, atxA. Second, we generated random transcriptional lacZ fusions in B. anthracis with transposon Tn917-LTV3. Transposon-insertion libraries were screened for mutants expressing CO2-enhanced atxA-dependent beta-galactosidase activity. DNA sequence analysis of transposon insertion sites in 17 mutants carrying CO2- and atxA-regulated fusions revealed 10 mutants carrying independent insertions on the 185-kb toxin plasmid pXO1 which did not map to the toxin genes. The tcr-lacZ fusion mutants (tcr for toxin coregulated) were Tox+, indicating that these genes may not be involved in anthrax toxin gene activation. Our data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins. 
 Question: Which metabolite activates AtxA?
Output: co2
Context: Consensual diagnostic criteria for facioscapulohumeral dystrophy (FSHD) include onset of the disease in facial or shoulder girdle muscles, facial weakness in more than 50% of affected family members, autosomal dominant inheritance in familial cases, and evidence of myopathic disease in at least one affected member without biopsy features specific to alternative diagnoses. Six patients did not meet most of these criteria but were diagnosed as FSHD by DNA testing, which showed small EcoRI fragments on chromosome 4q. Their clinical signs and symptoms and results of auxiliary investigations are reported. The patients presented with foot extensor, thigh, or calf muscle weakness. None of them had apparent facial weakness, only one complained of weakness in the shoulders, none had a positive family history. Expert physical examination, however, showed a typical facial expression, an abnormal shoulder configuration on lifting the arms, or scapular winging. This raised the suspicion of FSHD, whereupon DNA analysis was done. In conclusion, the clinical expression of FSHD is much broader than indicated by the nomenclature. The possibility to perform DNA tests is likely to greatly expand the clinical range of FSHD. 
 Question: What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?
Output: autosomal dominant
Context: The median income for a household in the city in 2000 was $29,378 (2010$37,436), and the median income for a family was $41,158. Males had a median income of $32,929 versus $26,856 for females. The per capita income for the city was $17,076. About 20.2% of families and 25.9% of the population were below the poverty line, including 41.5% of those under age 18 and 5.6% of those age 65 or over. 
 Question: What group had the smallest percentage below the poverty line?
Output: age 65 or over
Context: De Grolsch Veste (Dutch pronunciation: (d rls fst), English: The Grolsch Fortress, previously known as Arke Stadion (rk stadijn)) is the stadium of football club FC Twente. 
 Question: What team uses De Grolsch Veste?
Output: fc twente
Context: Future Life Pets By DogTown Media, LLC Open iTunes to buy and download apps. *Price: $2.99 *Category: Lifestyle *Updated: Jan 07, 2012 *Version: 1.1 *Size: 36.3 MB *Language: English *Seller: DOG TOWN MEDIA *(c) DogTown Media LLC Description DISCOVER FUTURE LIFETIMES WITH YOUR PETS You can be transported into the future to be reunited with your pet in another place and time. As an internationally recognized psychic and best-selling author, Anne Jirsch will be your guide in this fascinating meditation game. Future Life Pets will take you into a state of deep relaxation to help you understand this special condition. With expert hypnosis you can discover how your paths will cross in your future lifetime. WHAT PEOPLE ARE SAYING "I immediately saw I was riding a tall black and white horse and you've guessed it --it was my dog and this time he was bigger than ever." --Mike from Kansas City. "Seeing both my cats in the future lifetime has given me so much joy. They are both cats again next time around, only a lot bigger and smoother. I clearly saw them both lie by my feet just as they do right now." --Felicity from Manchester, UK. The regular buyers of Anne's products include heads of industry, politicians, and celebrities of all kinds. She is a world famous psychic and author of three books Instant Intuition, The Future is Yours, and Cosmic Energy. More than a billion people in the world believe in the truth of meditation, through which we'll gain a greater understanding of our pets and ourselves. Prepare for the experience as the results are astonishing. 
 Question: If we want to use the app of Future Life Pets, what kind of language should we know?
Output: english
Context: The Great Red Spot is a persistent anticyclonic storm on the planet Jupiter, 22 south of the equator, which has lasted for at least 186 years and possibly as long as 351 years or more. 
 Question: On what celestial body is Great Red Spot located?
Output: jupiter
Context: Speaking and Reading In learning a foreign language, one should first pay attention to speaking. It is the groundwork of reading and writing. You'd better try your best to speak. Don't be afraid of making mistakes. While you are doing this, a good exercise is to write --keep a diary, write notes or letters and so on. Many mistakes in your speaking will be easily found when you write. Through correcting the mistakes, you can do better in learning a language. If you are slow in speaking, don't worry. One of the helpful ways is to improve your English by reading, either aloud or low to yourself. The important thing is to choose something interesting to read. It mustn't be too difficult for. When you are reading in this way, don't stop to look up the words if you can guess their meaning of if they are not important to the sentence. You can do that some other time. 
 Question: Which is the groundwork while you are learning a foreign language?
Output: speaking
Context: The Avi Chai Foundation is a private foundation endowed in 1984 by Zalman Bernstein, a well-known successful investor and founder of Sanford Bernstein. 
 Question: Who is the founder of Avi Chai Foundation?
Output: zalman bernstein
Context: John Albert Taylor (June 6, 1959 -- January 26, 1996) was an American who was convicted of burglary and carrying a concealed weapon in the state of Florida, and sexual assault and murder in the state of Utah. 
 Question: For what crime was John Albert Taylor prosecuted?
Output: murder
Context: Perkonkrusts (Latvian pronunciation: (per.kon.krusts), ''Thunder Cross''), was a Latvian ultra-nationalist, anti-German and antisemitic political party founded in 1933 by Gustavs Celmins, borrowing elements of German nationalism--but being unsympathetic to German National Socialism at the time--and Italian fascism. 
 Question: Who led Perkonkrusts?
Output: gustavs celmiņš
Context: Siedlce Voivodeship (Polish: wojewodztwo siedleckie) was a unit of administrative division and local government in Poland in years 1975--1998, superseded by Masovian Voivodeship and Lublin Voivodeship. 
 Question: When was Siedlce Voivodeship abolished?
Output: 1998
Context: Coming off their Sunday night road win over the Packers, the Cowboys went home for a Week 4 NFC East showdown with the Washington Redskins. In the first quarter, the 'Boys shot first as QB Tony Romo completed a 21-yard TD pass to TE Jason Witten. In the second quarter, the Redskins took the lead as QB Jason Campbell completed a 3-yard TD pass to WR James Thrash and a 2-yard TD pass to WR Antwaan Randle El, along with kicker Shaun Suisham getting a 20-yard field goal. Dallas closed out the half with kicker Nick Folk getting a 36-yard field goal. In the third quarter, the Cowboys tied the game with Romo completing a 10-yard TD pass to WR Terrell Owens. Washington would respond with Suisham kicking a 33-yard field goal. In the fourth quarter, the Redskins increased their lead with Suisham nailing a 33-yard and a 29-yard field goal. The 'Boys tried to rally as Romo completed an 11-yard TD pass to WR Miles Austin. However, Dallas' onside kick attempt failed, preserving the Redskins' win. 
 Question: Which team had the least points at half?
Output: dallas
Context: The Chargers' fourteenth game was an interconference duel with the 49ers which was played on Thursday Night. The Chargers took a quick lead with QB Philip Rivers throwing a 58-yard TD pass to WR Vincent Jackson. The lead was extended in the second quarter by kicker Nate Kaeding nailing a 25-yard field goal, followed by Rivers finding Jackson on an 11-yard touchdown pass. The Chargers continued to dominate with FB Mike Tolbert getting a 1-yard TD run, followed by Rivers connecting to Jackson on a 48-yard TD pass, then with Kaeding hitting a 39-yard field goal. The 49ers made their only score of the game with RB Brian Westbrook getting a 1-yard TD run. This game was also a blowout and San Diego improved to 8-6. 
 Question: How many yards was the shortest touchdown run?
Output: 1-yard
Context: Little from the Fish Shop (Czech: Mala z rybarny) is a Czech animated film written and directed by Jan Balej. 
 Question: What was the name of the director for Little from the Fish Shop?
Output: jan balej
Context: Winslow Homer was the second of three sons of Henrietta Benson and Charles Savage Homer. He was born in Boston, Massachusetts in 1836 and grew up in Cambridge. His father was an importer of tools and other goods. His mother was a painter. Window got his interest in drawing and painting from his mother. But his father also supported his son's interest. Once, on a business trip to London, Charles Homer bought a set of drawing examples for his son to copy. Young Winslow used these to develop his early skill. Winslow's older brother Charles went to Harvard University in Cambridge. The family expected Winslow would go, too. But, at the time, Harvard did not teach art. So Winslow's father found him a job as an assistant in the trade of making and preparing pictures for printed media. At 19, Window learned the process of lithography .This work was the only formal training that Winslow ever received in art. In 1859, Window Homer moved to New York City to work for Harper's Weekly. Homer also started to paint seriously. He hoped to go to Europe to study painting. But, something would intervene the direction of Window Homer's artistic work. Harper's magazine would send him to draw pictures of the biggest event in American history since independence. It was the Civil War between the Union and the rebel southern states. Winslow Homer went to Washington, D. C., in 1861. He drew pictures of the campaign of Union Army General George McClellan the next year. His pictures of the war showed many ways that conflicts affect people. 
 Question: Who had the same interest as Window according to the text?
Output: his mother.
Context: Mr. Eckerd at the end of the street was a different fellow with a different kind of house. He let kids from the neighborhood come to see his house, but only if they had written permission from their parents, and if he'd already spoken to the parents before. What made it so different? He shared his home with rescued animals that the county couldn't keep. He had the permission to have things like monkeys, large cats, and other strange creatures. His house had the ivy -covered brick wall and the iron gate across the driveway. Once you went inside, the hedges lining the driveway were carved into the shapes of animals. There were other pretty plants on the grounds, too. The old brick house held a lot of surprises. The double doors with the lion's head door knockers opened into a large flat entryway. In the wooden board walls all around, there were fish tanks with colorful fishes. The ceilings were painted with scenes of plants and rare animals. Room opened off from there. Continuing down the hall, you came to a large courtyard, which had been caged in, partly open to the sky .A large group of tiny monkeys shook up and down trees. You had to walk through a caged tunnel into other parts of the house. They called out to whoever walked in, hoping for treats of fruits, nuts, and seeds. Behind that, the hall continued to a room full of snakes and lizards. It felt like a desert in that room, so dry and hot. It was not everyone's favorite room, but it certainly was interesting. The final room was actually out back, and definitely not something to miss. It was much like a large glass bird cage or a greenhouse. It was there that you would usually find Mr Eckerd on a bench next to some carvings of jungle animals. He was watching the Bengal tiger that wandered back and forth inside the cage. Mr. Eckerd's house was the strangest and most unique place in town, a place very well worth seeing. 
 Question: What exhibit or animal room seemed to be the least popular for most people?
Output: the snakes and lizards.
Context: Cystic fibrosis (CF) is the most common inherited disorder in Caucasian populations, with over 1400 mutations identified in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. Mutations in the CFTR gene may be also causative for CBAVD (Congenital Bilateral Absence of the Vas Deferens). The type and distribution of mutations varies widely between different countries and/or ethnic groups, and is relatively unknown in Iran. We therefore performed a comprehensive analysis of the CFTR gene in Iranian CF patients. 69 Iranian CF patients, and 1 CBAVD patient, were analysed for mutations in the complete coding region, and its exon/intron junctions, of their CFTR genes, using different methods, such as ARMS (amplification refractory mutation system)-PCR, SSCP (single stranded conformation polymorphism) analysis, restriction enzyme digestion analysis, direct sequencing, and MLPA (Multiplex Ligation-mediated Probe Amplification). CFTR mutation analysis revealed the identification of 37 mutations in 69 Iranian CF patients. Overall, 81.9% (113/138) CFTR genes derived from Iranian CF patients could be characterized for a disease-causing mutation. The CBAVD patient was found to be homozygous for the p.W1145R mutation. The most common mutations were p.F508del (DeltaF508) (18.1%), c.2183_2184delAAinsG (2183AA>G) (6.5%), p.S466X (5.8%), p.N1303K (4.3%), c.2789+5G>A (4.3%), p.G542X (3.6%), c.3120+1G>A (3.6%), p.R334W (2.9%) and c.3130delA (2.9%). These 9 types of mutant CFTR genes totaled for 52% of all CFTR genes derived from the 69 Iranian CF patients. Eight mutations, c.406-8T>C, p.A566D, c.2576delA, c.2752-1_2756delGGTGGCinsTTG, p.T1036I, p.W1145R, c.3850-24G>A, c.1342-?_1524+?del, were found for the first time in this study. We identified 37 CFTR mutations in 69 well characterized Iranian CF patients, obtaining a CFTR mutation detection rate of 81.9%, the highest detection rate obtained in the Iranian population so far. These findings will assist in genetic counseling, prenatal diagnosis and future screening of CF in Iran. 
 Question: Which is the most common CFTR mutation in Caucasians?
Output: deltaf508
Context: Taste of Chocolate is the third album by emcee Big Daddy Kane, released in late 1990 on Cold Chillin' Records. 
 Question: What is the name of Taste of Chocolate's record label?
Output: cold chillin' records
Context: To assess the efficacy and safety of tanezumab, a humanized monoclonal antibody directed against the pain-mediating neurotrophin, nerve growth factor, to treat pain and other symptoms of chronic prostatitis/chronic pelvic pain syndrome in a Phase IIa, proof-of-concept clinical trial powered to provide 2-sided 90% confidence interval around the primary endpoint. Patients received a single intravenous dose of tanezumab (20 mg) or placebo. The primary efficacy endpoint was the change from baseline to week 6 in average daily numerical rating scale pain score. The secondary endpoints included the change from baseline to week 6 in the National Institutes of Health Chronic Prostatitis Symptom Index and urinary symptoms. Safety was also assessed. Overall, 62 patients were randomized (30 to tanezumab and 32 to placebo). At week 6, tanezumab marginally improved the average daily pain (least-squares mean difference from placebo -0.47, 90% confidence interval -1.150-0.209) and urgency episode frequency (least-squares mean difference from placebo -1.37, 90% confidence interval -3.146-0.401). No difference was seen in the National Institutes of Health chronic prostatitis symptom index total score or micturition frequency at week 6. The most common adverse events were paresthesia and arthralgia. The odds of having a 30% reduction in pain were 1.75-fold greater (90% confidence interval 0.65-4.69) for patients receiving tanezumab versus placebo. Tanezumab might improve symptoms for some patients with chronic prostatitis/chronic pelvic pain syndrome. Although proof of concept was not demonstrated in the present study, additional studies with larger populations and stricter inclusion criteria according to patient phenotype might identify populations in which antinerve growth factor treatment will provide clinical benefit. 
 Question: What is the target of tanezumab?
Output: ngf
Context: To assess the efficacy and safety of tanezumab, a humanized monoclonal antibody directed against the pain-mediating neurotrophin, nerve growth factor, to treat pain and other symptoms of chronic prostatitis/chronic pelvic pain syndrome in a Phase IIa, proof-of-concept clinical trial powered to provide 2-sided 90% confidence interval around the primary endpoint. Patients received a single intravenous dose of tanezumab (20 mg) or placebo. The primary efficacy endpoint was the change from baseline to week 6 in average daily numerical rating scale pain score. The secondary endpoints included the change from baseline to week 6 in the National Institutes of Health Chronic Prostatitis Symptom Index and urinary symptoms. Safety was also assessed. Overall, 62 patients were randomized (30 to tanezumab and 32 to placebo). At week 6, tanezumab marginally improved the average daily pain (least-squares mean difference from placebo -0.47, 90% confidence interval -1.150-0.209) and urgency episode frequency (least-squares mean difference from placebo -1.37, 90% confidence interval -3.146-0.401). No difference was seen in the National Institutes of Health chronic prostatitis symptom index total score or micturition frequency at week 6. The most common adverse events were paresthesia and arthralgia. The odds of having a 30% reduction in pain were 1.75-fold greater (90% confidence interval 0.65-4.69) for patients receiving tanezumab versus placebo. Tanezumab might improve symptoms for some patients with chronic prostatitis/chronic pelvic pain syndrome. Although proof of concept was not demonstrated in the present study, additional studies with larger populations and stricter inclusion criteria according to patient phenotype might identify populations in which antinerve growth factor treatment will provide clinical benefit. 
 Question: What is the target of tanezumab?
Output: nerve growth factor
Context: In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimer's disease mouse model. 
 Question: Which disease the London mutation involved in?
Output: alzheimer's disease
Context: In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimer's disease mouse model. 
 Question: Which disease the London mutation involved in?
Output: ad
Context: To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2-p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13), homologous to the ligands of TNF-alpha and TNF-beta, genes that have previously been associated with migraine. The NOTCH3 gene was analysed by sequencing all exons with known CADASIL mutations in a typical (non-familial hemiplegic) migraine family (MF1) that has previously been shown to be linked to C19p13. The TNFSF7 gene was investigated through SNP association analysis using a matched case-control migraine population. NOTCH3 gene sequencing results for affected members of MF1 proved to be negative for all known sequence variants giving rise to mutations for CADASIL. TNFSF7 gene chi-square results showed non-significant P values across all populations tested against controls, except for the MO subgroup which displayed a possible association with the TNFSF7 SNP (genotype, allele analysis P = 0.036, P = 0.017 respectively). Our results suggest that common migraine is not caused by any known CADASIL mutations in the NOTCH3 gene of interest. However, the TNFSF7 gene displayed signs of involvement in a MO affected population and indicates that further independent studies of this marker are warranted. 
 Question: Which gene is involved in CADASIL?
Output: notch3 gene
Context: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both hospital and community infections globally. It's important to illuminate the differences between community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA), but there have been confusions on the definition, especially for the MRSA isolates identified within 48h of admission. This study aimed to determine the molecular characteristics and virulence genes profile of CA and HA-MRSA isolates identified less than 48h after hospital admission in our region. A total 62 MRSA isolates identified within 48h after admission and the clinical data were collected. Antimicrobial susceptibility test (AST) of collected isolates were performed according to the guidelines of Clinical and Laboratory Standards Institute (CLSI) 2015, and staphylococcal cassette chromosome mec (SCCmec) typing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE) and virulence gene profiling were performed to explore the molecular diversity. SCCmec III and sequence type (ST) 239 were the most prevalent SCCmec type and ST in both CA and HA-MRSA groups. HA-MRSA group had higher prevalence of SCCmec III (87.2%) and ST239 (79.5%) compared with CA-MRSA (60.9 and 43.4%, both P<0.001), while the frequency of SCCmec IV (26.0%) and ST59 (21.7%) were higher in CA-MRSA than its counterpart (P<0.001 and P=0.003). MRSA-ST239-III was the predominant type in this study (61.3%, 38/62), especially in HA-MRSA group (76.9%, 30/39). However, CA-MRSA strains exhibited more diversity in genotypes in this study. Meanwhile, CA-MRSA tended to have lower resistant percentage to non--lactams antibiotics but more virulence genes carriage, especially the staphylococcal enterotoxins (SE) genes. Notably, seb gene was only detected in CA-MRSA isolates (52.2%), likely a significant marker for CA-MRSA isolates. Panton-Valentine leukocidin gene (PVL) was highly detected in both groups, while appeared no significantly different between CA-MRSA (47.8%) and HA-MRSA (43.6%). Our findings support a difference in the molecular epidemiology and virulence genes profile of CA-MRSA and HA-MRSA. Furthermore, this study indicates a possible transmission from HA-MRSA to CA-MRSA, which may cause the overlap of the definition. 
 Question: What is MRSA?
Output: mrsa
Context: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both hospital and community infections globally. It's important to illuminate the differences between community-acquired MRSA (CA-MRSA) and hospital-acquired MRSA (HA-MRSA), but there have been confusions on the definition, especially for the MRSA isolates identified within 48h of admission. This study aimed to determine the molecular characteristics and virulence genes profile of CA and HA-MRSA isolates identified less than 48h after hospital admission in our region. A total 62 MRSA isolates identified within 48h after admission and the clinical data were collected. Antimicrobial susceptibility test (AST) of collected isolates were performed according to the guidelines of Clinical and Laboratory Standards Institute (CLSI) 2015, and staphylococcal cassette chromosome mec (SCCmec) typing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE) and virulence gene profiling were performed to explore the molecular diversity. SCCmec III and sequence type (ST) 239 were the most prevalent SCCmec type and ST in both CA and HA-MRSA groups. HA-MRSA group had higher prevalence of SCCmec III (87.2%) and ST239 (79.5%) compared with CA-MRSA (60.9 and 43.4%, both P<0.001), while the frequency of SCCmec IV (26.0%) and ST59 (21.7%) were higher in CA-MRSA than its counterpart (P<0.001 and P=0.003). MRSA-ST239-III was the predominant type in this study (61.3%, 38/62), especially in HA-MRSA group (76.9%, 30/39). However, CA-MRSA strains exhibited more diversity in genotypes in this study. Meanwhile, CA-MRSA tended to have lower resistant percentage to non--lactams antibiotics but more virulence genes carriage, especially the staphylococcal enterotoxins (SE) genes. Notably, seb gene was only detected in CA-MRSA isolates (52.2%), likely a significant marker for CA-MRSA isolates. Panton-Valentine leukocidin gene (PVL) was highly detected in both groups, while appeared no significantly different between CA-MRSA (47.8%) and HA-MRSA (43.6%). Our findings support a difference in the molecular epidemiology and virulence genes profile of CA-MRSA and HA-MRSA. Furthermore, this study indicates a possible transmission from HA-MRSA to CA-MRSA, which may cause the overlap of the definition. 
 Question: What is MRSA?
Output: methicillin-resistant s. aureus
Context: Respirasomes are macromolecular assemblies of the respiratory chain complexes I, III and IV in the inner mitochondrial membrane. We determined the structure of supercomplex I 
 Question: Where is the respirasome located?
Output: in the inner mitochondrial membrane
Context: As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese. 
 Question: Which group from the census is smaller: German American or English American?
Output: english american
Context: Kim Sul-song, or Kim Seol-song (born December 30, 1974), is the daughter of North Korea's former leader Kim Jong-Il and Kim Young-sook. 
 Question: Which lady Kim Sul-song was born to?
Output: kim young-sook
Context: Cambridge University Botanic Garden We run a lively programme of family events, life-long learning courses and much more throughout the year. Improve your Digital Photography This course led by award-winning photographer, Pete Murray, will show you how to take control of your camera. Using a proven "step by step approach" you will gain confidence in using your camera. Date:29/09 Time:10 am--4 pm Price:PS60 Event Category: Garden Photography 'Handbag' Baskets New to the Botanic Garden, this course will give you the opportunity to make your very own beautiful 'handbag basket'from a design that local basketry maker, Debbie Hall, developed herself. They have proved very popular since she started teaching the technique. Date: 07/10 Time: 10 am --4:30 pm Price: PS120 Event Category: Weaving & Basketry Trees and Shrubs for Autumn Color Join Mark Crouch, a specialist in the care of trees, for this course on choosing trees and shrubs to create beautiful autumn displays for your garden. The day will include a talk in our classroom and a tour of the Botanic Garden to look at autumn color and interest across our tree and shrub collection. Date: 17/10 Time: 10 am --4 pm Price: PS50 Event Category: Gardens and Plants Introduction to Botanical Subjects in Colored Pencil If you are interested in beginning to use colored pencils to draw botanical subjects, then this is the course for you. Janie Pirie is one of the country's leading pencil artists and on this one-day course she will show you the basic techniques used when working with colored pencils. Date: 16/10 Time: 10 am --4 pm Price: PS40 Event Category: Botanical Art 
 Question: How much would you pay if you wanted to learn to take better pictures?
Output: ps60.
Context: Mega Man Star Force 2, known in Japan as Shooting Star Rockman 2 (2 Ryusei no Rokkuman Tsu), is a video game developed by Capcom for the Nintendo DS handheld game console. 
 Question: Who worked on Mega Man Star Force 2?
Output: capcom
Context: Alpha-synuclein is phosphorylated at serine 129 (Ser129) in intracellular protein aggregates called Lewy bodies. These inclusion bodies are the characteristic pathologic lesions of Parkinson disease. Here we define the role of phosphorylation of Ser129 in alpha-synuclein toxicity and inclusion formation using a Drosophila model of Parkinson disease. Mutation of Ser129 to alanine to prevent phosphorylation completely suppresses dopaminergic neuronal loss produced by expression of human alpha-synuclein. In contrast, altering Ser129 to the negatively charged residue aspartate, to mimic phosphorylation, significantly enhances alpha-synuclein toxicity. The G protein-coupled receptor kinase 2 (Gprk2) phosphorylates Ser129 in vivo and enhances alpha-synuclein toxicity. Blocking phosphorylation at Ser129 substantially increases aggregate formation. Thus Ser129 phosphorylation status is crucial in mediating alpha-synuclein neurotoxicity and inclusion formation. Because increased number of inclusion bodies correlates with reduced toxicity, inclusion bodies may protect neurons from alpha-synuclein toxicity. 
 Question: Which residue of alpha-synuclein was found to be phosphorylated in Lewy bodies?
Output: serine 129
Context: The median age in the city was 35.1 years. 24.2% of residents were under the age of 18; 7.9% were between the ages of 18 and 24; 33.8% were from 25 to 44; 24.6% were from 45 to 64; and 9.5% were 65 years of age or older. The gender makeup of the city was 48.6% male and 51.4% females. 
 Question: Which age group is smaller: under the age of 18 or 18 and 24?
Output: 18 and 24
Context: Hoping to build on their home win over the Jets, the Browns flew to Qualcomm Stadium to take on the throwback-clad San Diego Chargers. In the first quarter, things started off close with Chargers kicker Nate Kaeding getting a 29-yard field goal, while Browns kicker Phil Dawson nailed a 37-yarder. In the second quarter, Dawson would get a 20-yard field goal for Cleveland. However, San Diego got the first touchdown of the game, as LB Marques Harris recovered a fumble in the Browns endzone for a touchdown. Dawson would supply the scoring for Cleveland for the rest of the half, as he nailed a 42-yarder and a 30-yarder. In the third quarter, the Chargers gained some momentum, as RB LaDainian Tomlinson, after getting bottled up in the first half, broke out with a 41-yard TD run for the only score of the period. In the fourth quarter, Dawson would get another field goal, which came from 36 yards out. However, San Diego would respond with Tomlinson getting a 7-yard TD run. Cleveland would have Dawson get a 35-yard field goal, yet Tomlinson would get an 8-yard TD run, which was followed by a successful two-point conversion from QB Philip Rivers to WR Vincent Jackson. The Browns would finally get a touchdown, as QB Charlie Frye completed a 4-yard TD pass to WR Braylon Edwards. Unfortunately, the damage was already done. With the loss, Cleveland would fall to 2-6. 
 Question: Who kicked the longer field goal in the first quarter?
Output: phil dawson
Context: Charles Wilson Cross died of a heart attack June 2, 1928, in Calgary. 
 Question: What was Charles Wilson Cross's cause of death?
Output: heart attack
Context: USS Benefit (1863) was a steamer acquired by the Union Navy during the American Civil War. 
 Question: What is the war during which USS Benefit (1863) was in the armed forces?
Output: american civil war
Context: What determines if a baby is a male or female? Recall that you have 23 pairs of chromosomesand one of those pairs is the sex chromosomes. Everyone has two sex chromosomes. Your sex chromosomes can be X or Y. Females have two X chromosomes (XX), while males have one X chromosome and one Y chromosome (XY). If a baby inherits an X chromosome from the father and an X chromosome from the mother, what will be the childs sex? The baby will have two X chromosomes, so it will be female. If the fathers sperm carries the Y chromosome, the child will be male. Notice that a mother can only pass on an X chromosome, so the sex of the baby is determined by the father. The father has a 50 percent chance of passing on the Y or X chromosome, so there is a 50 percent chance that a child will be male, and there is a 50 percent chance a child will be female. This 50:50 chance occurs for each baby. A couples first five children could all be boys. The sixth child still has a 50:50 chance of being a girl. One special pattern of inheritance that doesnt fit Mendels rules is sex-linked inheritance, referring to the inher- itance of traits that are located on genes on the sex chromosomes. Since males and females do not have the same sex chromosomes, there will be differences between the sexes in how these sex-linked traitstraits linked to genes located on the sex chromosomesare expressed. Sex-linked traits usually refer to traits due to genes on the X chromosome. One example of a sex-linked trait is red-green colorblindness. People with this type of colorblindness cannot tell the difference between red and green. They often see these colors as shades of brown ( Figure 1.1). Boys are much more likely to be colorblind than girls ( Table 1.1). This is because colorblindness is a sex-linked, recessive trait. Boys only have one X chromosome, so if that chromosome carries the gene for colorblindness, they will be colorblind. As girls have two X chromosomes, a girl can have one X chromosome with the colorblind gene and one X chromosome with a normal gene for color vision. Since colorblindness is recessive, the dominant normal gene will mask the recessive colorblind gene. Females with one colorblindness allele and one normal allele are referred to as carriers. They carry the allele but do not express it. How would a female become colorblind? She would have to inherit two genes for colorblindness, which is very unlikely. Many sex-linked traits are inherited in a recessive manner. Xc Xc X (carrier female) Xc Y (colorblind male) X Y X XX (normal female) XY (normal male) According to this Punnett square ( Table 1.1), the son of a woman who carries the colorblindness trait and a male with normal vision has a 50% chance of being colorblind. 
 Question: most sex-linked genes are ___________.
Output: recessive
Context: While Apocalypto is set during the terminal post-classic period of Maya civilization, the central pyramid of the film comes from the classic period, which ended in A.D. 900, such as those found in the Postclassic sites of Muyil, Coba, and others in Quintana Roo, Mexico, where later cities are built around earlier pyramids. 
 Question: Which place does Apocalypto exist in?
Output: mexico
Context: Sydney is one of the world's biggest cities and has something for everyone when he comes to shopping.You will find excellent Australian products alongside the best that the world has to offer.At the bottom of Sydney Tower, you can shop in 160 of Sydney's favorite stores including 16 jewellery stores and many gift and fashion shops.They're all at Westfield Centrepoint. Tel:9231 9300 SOVEREIGN HILL This prizewinning living museum is where Australia's history comes alive!Visit daily or stay for the night and experience life of the Gold Rush days.A wonderful nightly sound and light show,"Blood on the Southern Cross"tells the story of the famous Eureka Uprising.Enjoy shopping along with real life character and entertainment,4star hotel and breakfast. Tel:5331 1944 ANCHORAGE RESTAURANT Come and enjoy our delicious Cantonese seafood right on the water's edge in the historic fishing port of Williamstown with views of the city centre across Port Phillip Bay. Open 7 days a week Lunch:Sunday to Friday 11:00 a.m.2:00 p.m. Dinner:Monday to Saturday 5:00 p.m.10:00 p.m. Tel:9397 6270 or 9397 7799 COOK'S COTTAGE Built by James and Grace Cook,parents of Captain James Cook,Cook's Cottage stands proudly in the Fitzroy Gardens as a reminder of life in the eighteenth century,and as a celebration and commemoration of the life and travels of Captain James Cook. Open 9:00 a.m.5:00 p.m. daily, and until 5:30 pm during the summer. Tel:9419 4677 
 Question: Where can you spend the night in a tour?
Output: sovereign hill.
Context: Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21--q22. 
 Question: On what chromosome is Galectin-3 located?
Output: chromosome 14
Context: Coming off their divisional road win over the Rams, the Cardinals went home for a Week 10 NFC West rematch with the San Francisco 49ers on Monday Night Football. In the first quarter, Arizona trailed early as 49ers CB Allen Rossum returned the game's opening kickoff 104 yards for a touchdown. The Cardinals would respond as kicker Neil Rackers got a 28-yard field goal. In the second quarter, San Francisco added onto their lead as QB Shaun Hill completed a 31-yard TD pass to WR Josh Morgan. The Cardinals would answer with QB Kurt Warner completing a 13-yard TD pass to WR Anquan Boldin, along with Rackers getting a 33-yard field goal. The 49ers would close out the half with Hill completing an 18-yard TD pass to TE Vernon Davis. In the third quarter, Arizona crept closer again as Warner completed a five-yard TD pass to WR Larry Fitzgerald, yet San Francisco replied with kicker Joe Nedney getting a 41-yard field goal. In the fourth quarter, the Cardinals took the lead as Rackers nailed a 23-yard field goal, along with Warner hooking up with Boldin again on a five-yard TD pass (with a failed two-point conversion.) The 49ers would mount a late comeback drive, but Arizona made a successful goal-line stand as time ran out. 
 Question: Which team scored the first touchdown of the game?
Output: 49ers