niryuu/sni-each-converted huggingface dataset:
Context: The yeast Spt-Ada-Gcn5-acetyltransferase (SAGA) complex is a transcription coactivator that contains a histone H2B deubiquitination activity mediated by its Ubp8 subunit. Full enzymatic activity requires the formation of a quaternary complex, the deubiquitination module (DUBm) of SAGA, which is composed of Ubp8, Sus1, Sgf11, and Sgf73. The crystal structures of the DUBm have shed light on the structure/function relationship of this complex. Specifically, both Sgf11 and Sgf73 contain zinc finger domains (ZnF) that appear essential for the DUBm activity. Whereas Sgf73 N-terminal ZnF is important for DUBm stability, Sgf11 C-terminal ZnF appears to be involved in DUBm function. To further characterize the role of these two zinc fingers, we have solved their structure by NMR. We show that, contrary to the previously reported structures, Sgf73 ZnF adopts a C2H2 coordination with unusual tautomeric forms for the coordinating histidines. We further report that the Sgf11 ZnF, but not the Sgf73 ZnF, binds to nucleosomal DNA with a binding interface composed of arginine residues located within the ZnF -helix. Mutational analyses both in vitro and in vivo provide evidence for the functional relevance of our structural observations. The combined interpretation of our results leads to an uncommon ZnF-DNA interaction between the SAGA DUBm and nucleosomes, thus providing further functional insights into SAGA's epigenetic modulation of the chromatin structure. 
 Question: What does the SAGA complex acronym stands for?
Output: spt-ada-gcn5-acetyltransferase
Context: The King Willem-Alexander Canal (Dutch: Koning Willem-Alexanderkanaal), named after King Willem-Alexander of the Netherlands, is a 6 km long canal in the northeastern Netherlands. 
 Question: Who is the King Willem-Alexander Canal named after?
Output: willem-alexander of the netherlands
Context: Pirates of Treasure Island is a 2006 American comedy-drama film produced by The Asylum, loosely adaptated from Robert Louis Stevenson's novel Treasure Island. 
 Question: What studio produced Pirates of Treasure Island?
Output: the asylum
Context: Selexipag is a first-in-class orally available selective non-prostanoid IP receptor agonist. This review was based on a PubMed search and focuses on the potential role of selexipag in the treatment of pulmonary arterial hypertension (PAH). Selexipag is rapidly hydrolyzed to an active metabolite, ACT-333679. Both selexipag and its metabolite are highly selective for the IP receptor compared with other prostanoid receptors. This selectivity for the IP receptor offers the potential for improved tolerability with selexipag, as side effects (e.g., nausea and vomiting) that might result from activation of the other prostanoid receptors may be minimized. In addition, the selexipag metabolite has a half-life of 7.9 h, thus permitting oral dosing twice daily. Selexipag showed effects on pharmacodynamic end points obtained with right heart catheterization in a Phase II trial in patients with PAH, and is being evaluated in the ongoing Phase III trial (GRIPHON trial, Clinicaltrials.gov NCT01106014). The signal of a beneficial effect of selexipag on disease progression may become more robust for long term under prolonged exposure. Pending the GRIPHON trial results, selexipag could provide a convenient first-line prostacyclin treatment option for patients with PAH. 
 Question: Selexipag is used for which disease?
Output: pulmonary arterial hypertension
Context: Publius Minucius Augurinus (Latin, Publius Minucius Augurinus ) was a Roman Republican politician of the patrician gens Minucia during the beginning of the 5th century BC. He served as Consul of Rome in 492 BC 
 Question: What city was Publius Minucius Augurinus born in?
Output: rome
Context: As of the census of 2000, there were 120,546 people, 41,668 households, and 32,292 families residing in the county. The population density was 262 people per square mile (101/km). There were 43,903 housing units at an average density of 95 per square mile (37/km). The racial makeup of the county was 68.51% Race (United States Census), 26.06% Race (United States Census) or Race (United States Census), 0.75% Race (United States Census), 1.82% Race (United States Census), 0.06% Race (United States Census), 0.72% from Race (United States Census), and 2.08% from two or more races. 2.26% of the population were Race (United States Census) or Race (United States Census) of any race. 11.6% were of german people, 10.8% irish people, 10.2% english people, 9.3% American and 5.3% italian people ancestry. 
 Question: Which ancestral group is larger: English or Italian?
Output: english
Context: Amyloid precursor protein (AbetaPP), a precursor of amyloid beta (Abeta) peptide, is one of the molecules involved in the pathogenesis of Alzheimer's disease (AD). Specific mutations in AbetaPP have been found in patients inheriting familial AD (FAD). These mutant AbetaPP proteins cause cell death in neuronal cell lines in vitro, but the molecular mechanism of cytotoxicity has not yet been clarified completely. We analyzed the cytotoxic mechanisms of the London-type AbetaPP mutant, V642I-AbetaPP, in primary cortical neurons utilizing an adenovirus-mediated gene transfer system. Expression of V642I-AbetaPP protein induced degeneration of the primary neurons. This cytotoxicity was blocked by pertussis toxin, a specific inhibitor for heterotrimeric G proteins, Go/i, and was suppressed by an inhibitor of caspase-3/7 and an antioxidant, glutathione ethyl ester. A specific inhibitor for NADPH oxidase, apocynin, but not a xanthine oxidase inhibitor or a nitric oxide inhibitor, blocked V642I-AbetaPP-induced cytotoxicity. Among mitogen-activated protein kinase (MAPK) family proteins, c-Jun N-terminal kinase (JNK) and p38MAPK, but not extracellular regulated kinase (ERK), were involved in this cytotoxic pathway. The V642I-AbetaPP-induced cytotoxicity was not suppressed by two secretase inhibitors, suggesting that Abeta does not play a major role in this cytotoxicity. Two neuroprotective factors, insulin-like growth factor I (IGF-I) and Humanin, protected these primary neurons from V642I-AbetaPP-induced cytotoxicity. Furthermore, interleukin-6 and -11 also attenuated this cytotoxicity. This study demonstrated that the signaling pathway activated by mutated AbetaPP in the primary neurons is the same as that by the other artificial insults such as antibody binding to AbetaPP and the artificial dimerization of cytoplasmic domain of AbetaPP. The potential of neurotrophic factors and cytokines in AD therapy is also indicated. 
 Question: Which disease the London mutation involved in?
Output: alzheimer's disease
Context: Amyloid precursor protein (AbetaPP), a precursor of amyloid beta (Abeta) peptide, is one of the molecules involved in the pathogenesis of Alzheimer's disease (AD). Specific mutations in AbetaPP have been found in patients inheriting familial AD (FAD). These mutant AbetaPP proteins cause cell death in neuronal cell lines in vitro, but the molecular mechanism of cytotoxicity has not yet been clarified completely. We analyzed the cytotoxic mechanisms of the London-type AbetaPP mutant, V642I-AbetaPP, in primary cortical neurons utilizing an adenovirus-mediated gene transfer system. Expression of V642I-AbetaPP protein induced degeneration of the primary neurons. This cytotoxicity was blocked by pertussis toxin, a specific inhibitor for heterotrimeric G proteins, Go/i, and was suppressed by an inhibitor of caspase-3/7 and an antioxidant, glutathione ethyl ester. A specific inhibitor for NADPH oxidase, apocynin, but not a xanthine oxidase inhibitor or a nitric oxide inhibitor, blocked V642I-AbetaPP-induced cytotoxicity. Among mitogen-activated protein kinase (MAPK) family proteins, c-Jun N-terminal kinase (JNK) and p38MAPK, but not extracellular regulated kinase (ERK), were involved in this cytotoxic pathway. The V642I-AbetaPP-induced cytotoxicity was not suppressed by two secretase inhibitors, suggesting that Abeta does not play a major role in this cytotoxicity. Two neuroprotective factors, insulin-like growth factor I (IGF-I) and Humanin, protected these primary neurons from V642I-AbetaPP-induced cytotoxicity. Furthermore, interleukin-6 and -11 also attenuated this cytotoxicity. This study demonstrated that the signaling pathway activated by mutated AbetaPP in the primary neurons is the same as that by the other artificial insults such as antibody binding to AbetaPP and the artificial dimerization of cytoplasmic domain of AbetaPP. The potential of neurotrophic factors and cytokines in AD therapy is also indicated. 
 Question: Which disease the London mutation involved in?
Output: ad
Context: Loma just had to get in touch with someone:"I had to tell my best friend something important. I tried calling her but I couldn't get through. So I sent her an e-mail and then I spoke to her on MSN. Without technology I would not have been able to tell her. " Staying connected with friends and family is important for us. That's why we asked our readers to tell us how cell-phones, e-mail, blogs, text messaging, and personal pages help them keep in touch. More than 1,500 responded. Most of them told us they couldn't live without technology:80%of teens said they need technology to stay in touch. Almost 30%said they'd be completely out of their friends without their cell-phones and other methods of communication. What do they do when they've got news they need to share now? Most teens say they try to reach their friends by phone. But if they don't reach them, they use QQ, e-mails, and text messaging to _ Lots of people use one way of communication--like text messaging--to get a friend's attention and then use another where they can talk more. "My friends and I always tell each other everything that happens. So I send them text messages to tell them to come online so we can talk about it," said Sabeiha. "When planning to get together with friends", Julian said, "the easiest and fastest way I know is to send a text message to my contact group." Jocelyn said. "If I want to go to see a movie with a few friends, I usually send text message to them. By telephone, you have to call every single friend one by one. But text messaging allows you to send the same message to as many as you'd like, which saves a lot of time. 
 Question: What do most young people use first when they have news to tell their friends?
Output: phones.
Context: The Musee du Pantheon National Haitien was opened in 1983. 
 Question: When was Musee du Pantheon National Haitien opened officially?
Output: 1983
Context: Officials in the Midwestern U. S. town of Joplin, Missouri, say the death from Sundays' big tornado reaches 116 and that search efforts continue for possible survivors trapped in rubble . Search and rescue teams are conducting their third sweep through the nearly 10 kilometer - long and one - kilometer wide area of destruction left by the tornado. They are working as quickly as possible while weather conditions remain relatively stable. More storms are forecast for the area. Joplin Fire Chief Mitch Randles said there are areas with large piles of rubble that might hold survivors. "We are still finding individuals. We did rescue seven individuals from underneath rubble yesterday and, of course, we are also finding dead folks as well." Said more folks and that is why we are doing these searches. We want to make every opportunity that we can to find everybody that is in the rubble and that has survived to this point." Randles said the current sweep involves a slower pace that previous searches and that he plans a fourth search, possibly on Wednesday, using specially trained dogs. "We are searching every structure that has been damaged or destroyed in a more in-depth manner, "he said." I have dogs and dog handlers coming from all over the country do help us in that effort." Joplin City Manager Mark Rohr said the Red Cross and other volunteer organizations are helping people who were left homeless by the tornado and that the Federal Emergency Management Agency, or FEMA, is on hand to help. "Joplin is a great city. We have suffered a great loss, "said Rohr." We will recover and we will recover strongly and we have a lot of help and a lot of volunteers to make that easier." The tornado that struck Joplin was classified by the Natioonal Weather Service as an F - 4, with winds of more than 300 kilometers per hour. It lasted only 20 minutes, but it killed more that 100 people, injured more than 400 others, and destroyed or heavily damaged some 2,000 homes, businesses, churches and a hospital. Authorities have registered more than 1,700 calls about missing people and they hope to _ most of those cases soon, as victims are identified and survivors come forth and reunite with loved ones. This was the worst tornado to strike the United States in 60 years. It was the latest in a wave of violent storms that have swept Midwestern and southern states in recent weeks, leaving more than 300 people dead an causing more than $2 billion dollars in damage. 
 Question: What kind of disaster of this article is talking about?
Output: tornado
Context: Reactive oxygen species (ROS) have been known for a long time to play important roles in host defense against microbial infections. In addition, it has become apparent that they also perform regulatory roles in signal transduction and cell proliferation. The source of these chemicals are members of the NOX family of NADPH oxidases that are found in a variety of tissues. NOX1, an NADPH oxidase homologue that is most abundantly expressed in colon epithelial cells, requires the regulatory subunits NOXO1 (NOX organizing protein 1) and NOXA1 (NOX activating protein 1), as well as the flavocytochrome component p22(phox) for maximal activity. Unlike NOX2, the phagocytic NADPH oxidase whose activity is tightly repressed in the resting state, NOX1 produces superoxide constitutively at low levels. These levels can be further increased in a stimulus-dependent manner, yet the molecular details regulating this activity are not fully understood. Here we present the first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox). Using isothermal titration calorimetry we show that the isolated tandem SH3 domains of NOXO1 bind to p22(phox) with high affinity, most likely adopting a superSH3 domain conformation. In contrast, complex formation is severely inhibited in the presence of the C-terminal tail of NOXO1, suggesting that this region competes for binding to p22(phox) and thereby contributes to the regulation of superoxide production. Furthermore, we provide data indicating that the molecular details of the interaction between NOXO1 and NOXA1 is significantly different from that between the homologous proteins of the phagocytic oxidase, suggesting that there are important functional differences between the two systems. Taken together, this study provides clear evidence that the assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nadph oxidase 1
Context: Reactive oxygen species (ROS) have been known for a long time to play important roles in host defense against microbial infections. In addition, it has become apparent that they also perform regulatory roles in signal transduction and cell proliferation. The source of these chemicals are members of the NOX family of NADPH oxidases that are found in a variety of tissues. NOX1, an NADPH oxidase homologue that is most abundantly expressed in colon epithelial cells, requires the regulatory subunits NOXO1 (NOX organizing protein 1) and NOXA1 (NOX activating protein 1), as well as the flavocytochrome component p22(phox) for maximal activity. Unlike NOX2, the phagocytic NADPH oxidase whose activity is tightly repressed in the resting state, NOX1 produces superoxide constitutively at low levels. These levels can be further increased in a stimulus-dependent manner, yet the molecular details regulating this activity are not fully understood. Here we present the first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox). Using isothermal titration calorimetry we show that the isolated tandem SH3 domains of NOXO1 bind to p22(phox) with high affinity, most likely adopting a superSH3 domain conformation. In contrast, complex formation is severely inhibited in the presence of the C-terminal tail of NOXO1, suggesting that this region competes for binding to p22(phox) and thereby contributes to the regulation of superoxide production. Furthermore, we provide data indicating that the molecular details of the interaction between NOXO1 and NOXA1 is significantly different from that between the homologous proteins of the phagocytic oxidase, suggesting that there are important functional differences between the two systems. Taken together, this study provides clear evidence that the assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nicotinamide adenine dinucleotide phosphate-oxidase 1
Context: Reactive oxygen species (ROS) have been known for a long time to play important roles in host defense against microbial infections. In addition, it has become apparent that they also perform regulatory roles in signal transduction and cell proliferation. The source of these chemicals are members of the NOX family of NADPH oxidases that are found in a variety of tissues. NOX1, an NADPH oxidase homologue that is most abundantly expressed in colon epithelial cells, requires the regulatory subunits NOXO1 (NOX organizing protein 1) and NOXA1 (NOX activating protein 1), as well as the flavocytochrome component p22(phox) for maximal activity. Unlike NOX2, the phagocytic NADPH oxidase whose activity is tightly repressed in the resting state, NOX1 produces superoxide constitutively at low levels. These levels can be further increased in a stimulus-dependent manner, yet the molecular details regulating this activity are not fully understood. Here we present the first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox). Using isothermal titration calorimetry we show that the isolated tandem SH3 domains of NOXO1 bind to p22(phox) with high affinity, most likely adopting a superSH3 domain conformation. In contrast, complex formation is severely inhibited in the presence of the C-terminal tail of NOXO1, suggesting that this region competes for binding to p22(phox) and thereby contributes to the regulation of superoxide production. Furthermore, we provide data indicating that the molecular details of the interaction between NOXO1 and NOXA1 is significantly different from that between the homologous proteins of the phagocytic oxidase, suggesting that there are important functional differences between the two systems. Taken together, this study provides clear evidence that the assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nox1
Context: MPEG-4 Part 14 is an instance of the more general ISO/IEC 14496-12:2004 (MPEG-4 Part 12: ISO base media file format) which is directly based upon the QuickTime File Format. 
 Question: Which is the basis of MPEG-4 Part 14?
Output: iso base media file format
Context: Jeff Hardy is the son of Claude and Ruby Moore Hardy, and the younger brother of Matt Hardy. 
 Question: What is Jeff Hardy's brothers name?
Output: matt hardy
Context: Machado-Joseph disease (MJD), also called spinocerebellar ataxia type 3, is caused by mutant ataxin-3 with a polyglutamine expansion. Although there is no treatment available at present to cure or delay the onset of MJD, mouse models have been generated to facilitate the development of a therapy. In this review, the published reports on mouse models of MJD and other polyglutamine spinocerebellar ataxias are compared. Based on these studies, the following approaches will be discussed as candidate treatments for MJD: 1) interfering with the formation of the mutant ataxin-3 cleavage fragment and possibly aggregate or inclusions, 2) reducing the disease protein nuclear localization, and 3) decreasing mutant ataxin-3 expression in neurons. 
 Question: Which is the protein implicated in Spinocerebellar ataxia type 3?
Output: ataxin-3
Context: The Casa Natal del General Santander (lit., ''Birth house of General Santander'') is the birthplace of the Colombian General Francisco de Paula Santander, and is where he lived until the age of 13. 
 Question: The Casa Natal del General Santander was named for whom?
Output: francisco de paula santander
Context: A cynical and gothic look at Hollywood during the late 1930s, The Day of the Locust tells the tales of residents of the dilapidated San Bernardino Arms: Faye Greener, a trashy aspiring actress with limited talent, and her father Harry, a washed-up vaudevillian reduced to working as a door-to-door salesman; sexually repressed accountant Homer Simpson, who desperately loves Faye, and East Coast WASP Tod Hackett, an aspiring artist employed by the production department of a major studio, who also fancies Faye. There are unusual and bizarrely disturbing images: a middle-aged man sits in an untended garden staring at a large lizard that stares back; a young woman is transported into the film she's watching and finds herself portraying a harem girl in old Baghdad; a dwarf tenderly caresses a rooster, bleeding and dazed from a cock-fight, and then tosses it back into the ring to its death; an androgynous child beckons to a man through a window and performs a grotesque imitation of Mae West. These brief vignettes do little to advance the basic plot, but they serve to shape the audience's understanding of the era depicted as one of Hollywood sleaziness and wholesale alienation. Spectacle fills the screena set of the Waterloo battlefield collapses on the extras during the making of the film within the film. In the film's climax, an enraged Homer brutally tramples a child near Grauman's Chinese Theater as crowds gather for the premiere of a new film. Seeing this, the enraged crowd swarms over and kills Homer. Almost immediately, the entire crowd is driven to riot, turning on itself, smashing store windows, overturning cars, beating each other to death and turning the already packed street into a war zone. Severely injured, a delirious Tod imagines some of the mob taking on the appearance of the characters in his own grotesque painting The Burning of Los Angeles. 
 Question: What is the name of the young artist?
Output: tod hackett
Context: After a tough win over the Texans, the Steelers stayed home for a game against the Colts. In the first quarter, the Colts scored first as Adam Vinatieri nailed a 31-yard field goal for a 3-0 lead. However, the Steelers took the lead later on in the quarter when Ben Roethlisberger found Markus Wheaton on an 18-yard TD pass for a 7-3 game. In the 2nd quarter, the Steelers would score again increasing their lead as Roethlisberger found Martavis Bryant on a 5-yard TD pass for a 14-3 game. This was followed by William Gay picking off Andrew Luck and returning it 33 yards for a TD as they increased their lead to 21-3. The Colts however responded as Andrew Luck threw a 21-yard TD pass to Dwayne Allen for a 21-10 game. However, the Steelers pulled away as Roethlisberger would find Antonio Brown on 2 consecutive TD passes: from 8 and 47 yards out to increase their lead at first from 28-10 to 35-10. The Colts responded with 10 straight points first being Luck who found T. Y. Hilton on a 28-yard TD Pass for a 35-17 game followed by Vinatieri kicking a 23-yard field goal before halftime to make the score 35-20. The Steelers went back to work in the 3rd quarter as Roethlisberger and Bryant hooked up again on a 2-yard TD pass to increase their lead making the score 42-20. The Colts however were able to come within 8 later on when Ahmad Bradshaw ran for a 12-yard TD followed by Luck finding Donte Moncrief on a 31-yard TD pass to make the score 42-27 and then 42-34. In the 4th quarter, it was all Steelers when a penalty was enforced on Luck in the end zone for a safety making the score 44-34. The Steelers were able to seal the game later on when Roethlisberger found Heath Miller on an 11-yard TD pass for a final score of 51-34. Roethlisberger set franchise records with 522 yards passing and six touchdowns while picking up his 100th victory in his 150th start. Roethlisberger's yardage total was the fourth highest in NFL history. He became the first player in NFL history to go over 500 yards passing twice as the Steelers won consecutive games for the first time this season. 
 Question: Which team lost to the Steelers last week?
Output: texans
Context: I magliari (internationally released as The Magliari) is a 1959 Italian comedy drama film directed by Francesco Rosi. 
 Question: Who directed The Magliari?
Output: francesco rosi
Context: The Seahawks began their 2008 campaign on the road against the Buffalo Bills. In the first quarter, Seattle trailed early as Bills RB Marshawn Lynch got a 21-yard TD run. In the second quarter, the Seahawks continued to struggle as WR/PR Roscoe Parrish returned a punt 63 yards for a touchdown. Seattle responded with QB Matt Hasselbeck completing a 20-yard TD pass to WR Nate Burleson. Buffalo closed out the half with kicker Rian Lindell getting a 35-yard and a 38-yard field goal. In the third quarter, the Seahawks replied with kicker Olindo Mare nailing a 45-yard field goal. However, the Bills pulled a trick play on Seattle. Appearing to go for a 32-yard field goal, Buffalo's holder (punter Brian Moorman) instead threw a 19-yard TD pass to DE Ryan Denney. The Bills pulled away with QB Trent Edwards completing a 30-yard TD pass to TE Robert Royal. 
 Question: Which player scored more field goals, Rian Lindell or Olindo Mare?
Output: rian lindell
Context: TimAir is a charter airline based at the Sangster International Airport, Montego Bay, Jamaica. 
 Question: What airport is TimAir part of?
Output: sangster international airport
Context: The Na(+)/Ca(2+) exchanger (NCX) plays a role in the regulation of intracellular Ca(2+) levels, and nitric oxide (NO) is involved in many pathological conditions including neurodegenerative disorders. We have previously found that sodium nitroprusside (SNP), an NO donor, causes apoptotic-like cell death in cultured glial cells via NCX-mediated pathways and the mechanism for NO-induced cytotoxicity is cell type-dependent. The present study examined using the specific NCX inhibitor 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) whether NCX is involved in NO-induced injury in cultured neuronal cells. The treatment of neuroblastoma SH-SY5Y cells with SNP resulted in apoptosis and the cytotoxicity was blocked by the mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase inhibitor U0126 and the p38 MAP kinase (MAPK) inhibitor SB203580, but not by the c-Jun N-terminal kinase (JNK) inhibitor SP60012. SNP increased Ca(2+) influx and intracellular Ca(2+) levels. In addition, SNP increased ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. These effects of SNP were prevented by SEA0400. SNP-induced cytotoxicity was not affected by inhibitors of the Ca(2+), Na(+) and store-operated/capacitative channels. Moreover, SNP-induced increase in intracellular Ca(2+) levels, ROS production and decrease in cell viability were blocked by a cGMP-dependent protein kinase (PKG) inhibitor. These results suggest that Ca(2+) influx via the reverse of NCX is involved in the cascade of NO-induced neuronal apoptosis and NO activates the NCX through guanylate cyclase/PKG pathway. 
 Question: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
Output: na(+)/ca(2+) exchanger
Context: The Na(+)/Ca(2+) exchanger (NCX) plays a role in the regulation of intracellular Ca(2+) levels, and nitric oxide (NO) is involved in many pathological conditions including neurodegenerative disorders. We have previously found that sodium nitroprusside (SNP), an NO donor, causes apoptotic-like cell death in cultured glial cells via NCX-mediated pathways and the mechanism for NO-induced cytotoxicity is cell type-dependent. The present study examined using the specific NCX inhibitor 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) whether NCX is involved in NO-induced injury in cultured neuronal cells. The treatment of neuroblastoma SH-SY5Y cells with SNP resulted in apoptosis and the cytotoxicity was blocked by the mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase inhibitor U0126 and the p38 MAP kinase (MAPK) inhibitor SB203580, but not by the c-Jun N-terminal kinase (JNK) inhibitor SP60012. SNP increased Ca(2+) influx and intracellular Ca(2+) levels. In addition, SNP increased ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner. These effects of SNP were prevented by SEA0400. SNP-induced cytotoxicity was not affected by inhibitors of the Ca(2+), Na(+) and store-operated/capacitative channels. Moreover, SNP-induced increase in intracellular Ca(2+) levels, ROS production and decrease in cell viability were blocked by a cGMP-dependent protein kinase (PKG) inhibitor. These results suggest that Ca(2+) influx via the reverse of NCX is involved in the cascade of NO-induced neuronal apoptosis and NO activates the NCX through guanylate cyclase/PKG pathway. 
 Question: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?
Output: ncx
Context: It seems that the Great Wall is the place to rock . There will be two parties held on the Great Wall this month. Great Wall I The latest Great Wall party is sponsored by the Club and Elektrobeat and held at Jinshanling. Local DJ Mark, as well as guests Slab from Australia, Usami and Bobby from Hong Kong will sing at the party. All drinks are priced at 20 yuan($ 2.4). Tickets: 200yuan($ 24), including bus ride there and back plus entrance fee to the Great Wall. T/D: 8p.m. to 2 a.m., Sept. 20. Pre-sale tickets are to be booked at: Public Space: 6416-0759; Neo Lounge: 6416-1077. Buses: Leave at 5 p.m. on Saturday, Sept. 20 from Neo Lounge, 99 Xinfuncun Zhonglu, Sanlitun, Chaoyang District. For more info: www. elektrobeat. com Great wall II The other party at the end of this month at Jinshanling will be started with live performances by Askar, Brain Failure, Longkuan, Supermarket, Mr. Zhou, Beijing Talking and the Yi band. Dance till dawn to the wonderful sounds of DJs Ben, Mickey Zhang, Will, Cheese, Gao Hu and Huang Weiwei. T/D: 8 p.m. to 2 a.m., Sept. 27. Tickets: 350 yuan ($ 42) or 300 yuan ($ 36) for groups of 10 or more, 500 yuan ($ 60) at the door and VIP tickets 800 yuan ($ 72), transportation included. Buses: Depart from the north gate of Wbrkers' Stadium at noon, 2 p.m., 4 p.m., Sept. 27. For more info: contact Li Zhenhua at lah@msgp. Org or call 133-2119-1731. 
 Question: What day of the week is September 27?
Output: saturday.
Context: The Toi invasion was the invasion of northern Kyushu by Jurchen pirates in 1019. At the time, Toi meant "barbarian" in the Korean language. The Toi pirates sailed with about 50 ships from direction of Goryeo, then assaulted Tsushima and Iki, starting 27 March 1019. After the Iki Island garrison comprising 147 soldiers was wiped out, the pirates has proceed to Hakata Bay. For a week, using Noko Island in the Hakata Bay as a base, they sacked villages and kidnapped over 1,000 Japanese, mostly women and young girls, for use as slaves. The Dazaifu, the administrative center of Kyushu, then raised an army and successfully drove the pirates away. During the second failed raid to Matsuura 13 April 1019, three enemies were captured by the Japanese army. They were identified as Koreans. They said that they had guarded the borderland but had been captured by the Toi. However, this was unlikely, and the Japanese officers suspected them because there had been Korean pirates attacking Japan coasts during the Silla period. A few months later, the Goryeo delegate Jeong Jaryang reported that Goryeo forces attacked the pirates off Wonsan and rescued about 260 Japanese. The Korean government then repatriated them to Japan where they were thanked by the Dazaifu and given rewards. There remain detailed reports by two captive women, Kura no Iwame and Tajihi no Akomi. These Jurchen pirates lived in what is today Hamgyongdo, North Korea. 
 Question: Did the second raid to Matsuura succeed?
Output: second failed raid to matsuura
Context: The Samsung Galaxy Note 8.0 is an 8-inch Android-based tablet computer produced and marketed by Samsung Electronics. 
 Question: What company makes Samsung Galaxy Note 8.0?
Output: samsung electronics
Context: Coming off their home win over the Rams, the Bengals flew to Bill Walsh Field at Monster Park for a Saturday night interconference duel with the San Francisco 49ers. After a scoreless first quarter, Cincinnati trailed early in the second quarter as 49ers QB Shaun Hill got a 3-yard TD run. Afterwards, the Bengals would take the lead as kicker Shayne Graham managed to get a 24-yard field goal, while QB Carson Palmer completed a 52-yard TD pass to WR Chris Henry. San Francisco would end the half with Hill completing a 17-yard TD pass to TE Vernon Davis. In the third quarter, the 49ers increased their lead with kicker Joe Nedney getting a 29-yard and a 38-yard field goal. In the fourth quarter, Cincinnati tried to respond as Graham kicked a 35-yard field goal. However, the 49ers' defense held on for the win. With the loss, the Bengals fell to 5-9, securing Head Coach Marvin Lewis' first losing season with Cincinnati. 
 Question: How long was the longest field goal?
Output: a 38-yard field goal
Context: A frequent complication of Clostridium difficile infection (CDI) is recurrent disease. The aim of this study was to determine whether early recurrence risk was higher after infection with ribotype 027 (outbreak strain) compared with infection with endemic strain types of C.difficile. Consecutive patients diagnosed with CDI between May 2013 and March 2014 were included (outbreak strain, and non-outbreak strains). Patients who developed recurrent CDI within 30days after completion of CDI treatment, were compared with patients without a recurrence. Medical charts were reviewed for demographic and clinical characteristics. General practitioners were contacted to complete data about the occurrence of recurrent CDI, and the use of medication after hospital discharge. In total, 135 patients were at risk for the development of recurrent CDI; 74 patients were infected by ribotype 027, and 61 patients by other ribotypes. Thirty-nine patients (29%) developed recurrent CDI within 30days after completion of CDI treatment. In multivariable analysis, age 70years (HR 3.05, 95% CI 1.54-6.03), and a duration of CDI treatment 11days (HR 1.92, 95% CI 1.00-3.69) were clearly associated with recurrence; infection with ribotype 027 showed a HR of 1.72 (95% CI 0.88-3.33). During this outbreak of C.difficile in a tertiary care centre, age and a prolonged duration of CDI therapy (which is most likely a marker of underlying disease severity) were the main risk factors for recurrent CDI. This points to host factors as more important predictors for recurrent CDI than strain type or antibiotic use. 
 Question: Which main ribotype of Clostridium difficile is responsible of the recent outbreak?
Output: ribotype 027
Context: One major hallmark of Alzheimer's disease (AD) is the massive loss of synapses that occurs at an early clinical stage of the disease. In this study, we characterize alterations in spine density and the expression of synapse-associated immediate early gene Arc (activity-regulated cytoskeleton-associated protein) in the hippocampal CA1 regions of two different amyloid precursor protein (APP) transgenic mouse lines before plaque development and their connection to performance in hippocampus-dependent memory tests. The density of mushroom-type spines was reduced by 34% in the basal dendrites proximal to the soma of CA1 pyramidal neurons in 5.5-month-old Tg2576 mice, carrying the Swedish mutation, compared with wild-type littermates. A similar reduction of 42% was confirmed in the same region of 8-month-old APP/Lo mice, carrying the London mutation. In this strain, the reduction extended to the distal dendritic spines (28%), although no differences were found in apical dendrites in either transgenic mouse line. Both transgenic mice lines presented a significant increase in Arc protein expression in CA1 compared with controls, suggesting rather an overactivity and increased spine turnover that was supported by a significant decrease in number of somatostatin-immunopositive inhibitory interneurons in the stratum oriens of CA1. Behaviorally, the transgenic mice showed decrease freezing in the fear contextual conditioning test and impairment in spatial memory assessed by Morris water maze test. These data indicate that cognitive impairment in APP transgenic mice is correlated with impairment of synaptic connectivity in hippocampal CA1, probably attributable to loss of inhibitory interneurons and subsequent hyperactivity. 
 Question: Which disease the London mutation involved in?
Output: alzheimer's disease
Context: One major hallmark of Alzheimer's disease (AD) is the massive loss of synapses that occurs at an early clinical stage of the disease. In this study, we characterize alterations in spine density and the expression of synapse-associated immediate early gene Arc (activity-regulated cytoskeleton-associated protein) in the hippocampal CA1 regions of two different amyloid precursor protein (APP) transgenic mouse lines before plaque development and their connection to performance in hippocampus-dependent memory tests. The density of mushroom-type spines was reduced by 34% in the basal dendrites proximal to the soma of CA1 pyramidal neurons in 5.5-month-old Tg2576 mice, carrying the Swedish mutation, compared with wild-type littermates. A similar reduction of 42% was confirmed in the same region of 8-month-old APP/Lo mice, carrying the London mutation. In this strain, the reduction extended to the distal dendritic spines (28%), although no differences were found in apical dendrites in either transgenic mouse line. Both transgenic mice lines presented a significant increase in Arc protein expression in CA1 compared with controls, suggesting rather an overactivity and increased spine turnover that was supported by a significant decrease in number of somatostatin-immunopositive inhibitory interneurons in the stratum oriens of CA1. Behaviorally, the transgenic mice showed decrease freezing in the fear contextual conditioning test and impairment in spatial memory assessed by Morris water maze test. These data indicate that cognitive impairment in APP transgenic mice is correlated with impairment of synaptic connectivity in hippocampal CA1, probably attributable to loss of inhibitory interneurons and subsequent hyperactivity. 
 Question: Which disease the London mutation involved in?
Output: ad
Context: Aline Caroline de Rothschild, Lady Sassoon (21 October 1867 -- 28 July 1909) was a French socialite and daughter of Cecile Anspach and Baron Gustave de Rothschild of the prominent Rothschild family. 
 Question: What family lineage was Aline Caroline de Rothschild part of?
Output: rothschild family
Context: Princess Marie Melita of Hohenlohe-Langenburg (German: Marie Melita Leopoldine Viktoria Feodora Alexandra Sophie; 18 January 1899, Langenburg, Wurttemberg -- 8 November 1967, Munich, Germany) was the Duchess consort of Schleswig-Holstein as the wife of Wilhelm Friedrich, Duke of Schleswig-Holstein. 
 Question: What is Princess Marie Melita of Hohenlohe-Langenburg's spouse's name?
Output: wilhelm friedrich, duke of schleswig-holstein
Context: Autonomic failure with Lewy bodies (AF-LB) was first described by Fichefet et al. in 1965, and more than ten cases have been reported to date. AF-LB and Parkinson's disease (PD) share the neuropathological findings characterized by widely distributed Lewy bodies in the central nervous system including the substantia nigra and locus coeruleus. However, clinical manifestations of AF-LB are far different from PD in which autonomic dysfunction, if present, is not a predominant feature. In the present study, clinical features were comparatively analysed in AF-LB and PD to investigate the nosological relation between PD and AF-LB. The subjects were 94 patients with PD and 11 reported cases of AF-LB in the literature. A test of 70 degrees passive head-up tilt was performed upon the patients with PD in our laboratory. Based on the results in tilting test, the patients with PD were divided into two groups; PD-I (69 cases) with an orthostatic fall of systolic blood pressure less than 30 mmHg, and PD-II (25 cases) with a fall of 30 mmHg or more. Autonomic dysfunctions were more extent in PD-II than in PD-I, because the incidences of anhidrosis, impotence, neurogenic bladder and constipation were higher in PD-II. All of the cases of AF-LB were contained in the previous literatures with reasonably full clinical descriptions. Mean age at onset of the disease was 62.1 +/- 8.7 (mean +/- SD) years old in PD-I, 64.5 +/- 7.5 years old in PD-II and 63.9 +/- 9.0 years old in AF-LB, and no significant differences were found among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS) 
 Question: Which disease of the central nervous system is characterized by the presence of Lewy bodies?
Output: parkinson's disease (pd)
Context: Recently,I came across an interesting article on the differences between British English and American English. I had a lot of fun reading it and thinking of as many differences as I could as an American. Their cars have "bonnets ", while ourselves have "hoods". They park their cars in a "car park" while we leave ours in a "parking lot". Our "cookies" are their "biscuits", while their "rubbers" are our "erasers". Then there are the food words. Would you want to eat something called "Toad in the Hole" or "Bangers and Mash" or "Spotted Dick"? I'm here to report they are all very tasty. There are American equivalents ,of course. We've got "Shoofly Pie", "Chicken Fried Steak" and "Mississippi Mud Pie". What they call "crisps" is what we call "potato chips" and when we ask for "chips" in England we will get what we know at home in America as "French fries". They find it _ that we call the "toilet" the "bathroom" and they really double over with laughter when we ask for the "restroom". American ladies in England who ask for the "little girl's room" or the "powder room" will be met with blank stares. A "fag" is a "cigarette" in the UK, which can lead to endless confusion for British visitors looking for a cigarette in America. Americans on the other hand are endlessly confused by English signs put up over doorways saying "Way Out". We Americans walk on the sidewalk not the pavement. "Pavement" in America is the actual cement the sidewalk is made of. 
 Question: What do British people call French Fries?
Output: chips.
Context: Elizabeth Bishop, who was famous for the poetry A Prodigal, Filling Station , Sandpiper, Manuelzinho and so on, was an influential American poet of the 20th century. Her poetry often shows things that concerned her throughout her life, such as her search for a sense of home. Her troubled childhood and feelings of loneliness from this time affected her character and poetry. Bishop's painful childhood is apparent in some of her poems. Her father died when she was eight months old and her mother was mad when she was five. Bishop was raised firstly by her mother's parents and then by her father's parents. This experience left her confused about belonging. She had no home and this was shown in her poetry. In "A Prodigal", when the character in the poem makes up his mind to go home, there is a sense of pessimism for Bishop who has no home. The lack of a sense of home has contributed to her depression all her life. Bishop attempts to make small, everyday experiences extraordinary in her poems such as "Filling Station" .In "Filling Station ", Bishop describes the beautyof a family filling station. Although it is "dirty" there is order in it. Simple family life is celebrated in it. She recognizes the value of home and beauty in everyday life, but she is only an observer of these. Distance remains between her and the family at the filling station. Bishop's struggle to locate herself in the world is seen no more clearly than in "sandpiper". It deals with searching for something in a confusing world. She uses the metaphor of the bird which is "looking for something". The "something" isn't specific . It seems as if the bird doesn't know what he wants; the only certain thing is that he is searching. Bishop's poems are personal on a more subtle level, especially when her childhood, travels, etc, are taken into consideration. It is believed that Bishop is a complex poet who uses her poetry to find this feeling of belonging. 
 Question: Which of Bishop's poems shows her love for simple family life?
Output: "filling station"
Context: Something strange was unbelievable. Take Robert for example. After the terrible car accident, his whole world had been completely dark and quiet for almost ten years. The loss of sight and hearing made him try many times to put end to his life. His family especially his wife did their best to tend and comfort him. By and by he finally regained the courage to live on. On a hot summer afternoon he was taking a walk with a stick near his house when a thunderstorm started suddenly. He stood under a large tree in order not to get himself wet. Unfortunately he was struck down to the ground by a lightning. The witnesses thought him dead but he woke up some 20 minutes later lying face down in muddy water below the tree. He felt that he was trembling badly, but when he opened his eyes ,he didn't dare to believe that he saw a plough( )lying near the wall. When Mrs Edwards came running up to him, she shouted their neighbours for help. And he saw her and heard her voice for the first time in nearly ten years. The news of Robert's regaining his sight and hearing quickly spread in his area. And many doctors came to prove the truth of the news. Most of them said that he gained sight and hearing again obviously from the knock of lightning; none of them could give convincing reasons, however. The only reasonable explanation given by one doctor was that, since Edwards lost his sight and hearing as a result of sudden shock in a terrible accident, perhaps the only way for them to regain was by another sudden shock. 
 Question: What did Edwards see first after being struck down by a lightning?
Output: a plough