niryuu/sni-each-converted huggingface dataset:
Context: Osteoarthritis (OA) is a degenerative joint disorder commonly encountered in clinical practice, and is the leading cause of disability in elderly people. Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers, OA is a challenging disease with limited treatment options. Traditional pharmacologic therapies such as acetaminophen, non-steroidal anti-inflammatory drugs, and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events. Current research focuses on the development of new OA drugs (such as sprifermin/recombinant human fibroblast growth factor-18, tanezumab/monoclonal antibody against -nerve growth factor), which aims for more effectiveness and less incidence of adverse effects than the traditional ones. Furthermore, regenerative therapies (such as autologous chondrocyte implantation (ACI), new generation of matrix-induced ACI, cell-free scaffolds, induced pluripotent stem cells (iPS cells or iPSCs), and endogenous cell homing) are also emerging as promising alternatives as they have potential to enhance cartilage repair, and ultimately restore healthy tissue. However, despite currently available therapies and research advances, there remain unmet medical needs in the treatment of OA. This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. 
 Question: What is the target of tanezumab?
Output: ngf
Context: Osteoarthritis (OA) is a degenerative joint disorder commonly encountered in clinical practice, and is the leading cause of disability in elderly people. Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers, OA is a challenging disease with limited treatment options. Traditional pharmacologic therapies such as acetaminophen, non-steroidal anti-inflammatory drugs, and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events. Current research focuses on the development of new OA drugs (such as sprifermin/recombinant human fibroblast growth factor-18, tanezumab/monoclonal antibody against -nerve growth factor), which aims for more effectiveness and less incidence of adverse effects than the traditional ones. Furthermore, regenerative therapies (such as autologous chondrocyte implantation (ACI), new generation of matrix-induced ACI, cell-free scaffolds, induced pluripotent stem cells (iPS cells or iPSCs), and endogenous cell homing) are also emerging as promising alternatives as they have potential to enhance cartilage repair, and ultimately restore healthy tissue. However, despite currently available therapies and research advances, there remain unmet medical needs in the treatment of OA. This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. 
 Question: What is the target of tanezumab?
Output: nerve growth factor
Context: Parkinson's disease (PD) is one of many neurodegenerative diseases that are characterized by amyloid fibril formation. Alpha-synuclein is a primary component of the fibrillar neuronal inclusions, known as Lewy bodies, that are diagnostic of PD. In addition, the alpha-synuclein gene is linked to familial PD. Fibril formation by alpha-synuclein proceeds via discrete beta-sheet-rich oligomers, or protofibrils, that are consumed as fibrils grow. Both FPD mutations accelerate formation of protofibrils, suggesting that these intermediates, rather than the fibril product, trigger neuronal loss. In idiopathic PD, other factors may be responsible for accelerating protofibril formation by wild-type alpha-synuclein. One possible factor could be molecular crowding in the neuronal cytoplasm. We demonstrate here that crowding using inert polymers significantly reduced the lag time for protofibril formation and the conversion of the protofibril to the fibril, but did not affect the morphology of either species. Physiologically realistic changes in the degree of in vitro crowding have significant kinetic consequences. Thus, nonspecific changes in the total cytoplasmic protein concentration, induced by cell volume changes and/or altered protein degradation, could promote formation of and stabilize the alpha-synuclein protofibril. 
 Question: Which is the primary protein component of Lewy bodies?
Output: αsyn
Context: Parkinson's disease (PD) is one of many neurodegenerative diseases that are characterized by amyloid fibril formation. Alpha-synuclein is a primary component of the fibrillar neuronal inclusions, known as Lewy bodies, that are diagnostic of PD. In addition, the alpha-synuclein gene is linked to familial PD. Fibril formation by alpha-synuclein proceeds via discrete beta-sheet-rich oligomers, or protofibrils, that are consumed as fibrils grow. Both FPD mutations accelerate formation of protofibrils, suggesting that these intermediates, rather than the fibril product, trigger neuronal loss. In idiopathic PD, other factors may be responsible for accelerating protofibril formation by wild-type alpha-synuclein. One possible factor could be molecular crowding in the neuronal cytoplasm. We demonstrate here that crowding using inert polymers significantly reduced the lag time for protofibril formation and the conversion of the protofibril to the fibril, but did not affect the morphology of either species. Physiologically realistic changes in the degree of in vitro crowding have significant kinetic consequences. Thus, nonspecific changes in the total cytoplasmic protein concentration, induced by cell volume changes and/or altered protein degradation, could promote formation of and stabilize the alpha-synuclein protofibril. 
 Question: Which is the primary protein component of Lewy bodies?
Output: α-synuclein
Context: Parkinson's disease (PD) is one of many neurodegenerative diseases that are characterized by amyloid fibril formation. Alpha-synuclein is a primary component of the fibrillar neuronal inclusions, known as Lewy bodies, that are diagnostic of PD. In addition, the alpha-synuclein gene is linked to familial PD. Fibril formation by alpha-synuclein proceeds via discrete beta-sheet-rich oligomers, or protofibrils, that are consumed as fibrils grow. Both FPD mutations accelerate formation of protofibrils, suggesting that these intermediates, rather than the fibril product, trigger neuronal loss. In idiopathic PD, other factors may be responsible for accelerating protofibril formation by wild-type alpha-synuclein. One possible factor could be molecular crowding in the neuronal cytoplasm. We demonstrate here that crowding using inert polymers significantly reduced the lag time for protofibril formation and the conversion of the protofibril to the fibril, but did not affect the morphology of either species. Physiologically realistic changes in the degree of in vitro crowding have significant kinetic consequences. Thus, nonspecific changes in the total cytoplasmic protein concentration, induced by cell volume changes and/or altered protein degradation, could promote formation of and stabilize the alpha-synuclein protofibril. 
 Question: Which is the primary protein component of Lewy bodies?
Output: alpha-synuclein
Context: Leon Lemmens (born March 16, 1954 in Boorsem, Maasmechelen, Belgium) is a Roman Catholic auxiliary bishop in Belgium. 
 Question: Which was the position that Leon Lemmens held?
Output: bishop
Context: The Show Off (1926) is a silent film comedy produced by Famous Players-Lasky and distributed by Paramount Pictures, directed by Mal St. Clair, and starring Ford Sterling, Lois Wilson and Louise Brooks. 
 Question: What production company was involved in The Show Off?
Output: paramount pictures
Context: The Ak 5 or Automatkarbin 5 (''automatic carbine 5'', ''automatic carbine'' being the Swedish term for assault rifle) is the Swedish version of the FN FNC assault rifle with certain modifications, mostly to adapt the weapon to the Swedish climate. 
 Question: The Ak 5 is based upon what?
Output: fn fnc
Context: After he finished the 3D film, Bwana Devil (1952), The Twonky was finally released by United Artists. 
 Question: The distributor of The Twonky was whom?
Output: united artists
Context: The Human LGR5 gene is 144,810 bases long and located at chromosome 12 at position 12q22-q23.Both human, rat and mouse homologs contain 907 amino acids and seven transmembrane domains. 
 Question: Which chromosome is related with LGR5?
Output: chromosome 12
Context: The Browns were making their first trip to San Diego since 2006. The game was back and forth, with neither team leading by more than one possession. The Chargers led 7-3 after the 1st quarter. On the Browns' first drive of the second quarter, QB Josh McCown threw a 34-yard touchdown pass to RB Duke Johnson to put the Browns up 10-7. The teams traded field goals, making it a 13-13 game at halftime. The Browns scored a field goal at the start of the 3rd quarter to go up 16-13. On the Chargers' next drive, QB Philip Rivers led the Chargers to a touchdown, going up 20-16 heading into the 4th quarter. After K Travis Coons kicked a field goal to cut the deficit to 20-19, Rivers led another touchdown drive to put the Chargers up 27-19. On the Browns' next drive, they reached the end zone, assisted by an incredible catch by TE Gary Barnidge on the Chargers' 1 yard line. They converted on the two point conversion to tie the game at 27-27 with just over 2 minutes remaining. The Chargers reached the Browns' 24 yard line with under 50 seconds to play. The Browns began to use timeouts until the Chargers faced 4th down with 2 seconds to play. After the Chargers called timeout, their kicker had an opportunity to win the game with a 39-yard field goal. The 39 yard game winning attempt was off to the right, and the game appeared to be on its way to overtime.. However, CB Tramon Williams was flagged for being offside during the play, giving the Chargers another attempt, this time from 34 yards. The field goal was converted, and the Chargers won 30-27. The Browns committed 12 penalties in the game, including this critical offside penalty. 
 Question: What was score at the end of the third quarter?
Output: 20-16
Context: The McLeod syndrome is an X-linked disorder caused by mutations of the XK gene encoding the XK protein. The syndrome is characterized by absent Kx erythrocyte antigen, weak expression of Kell blood group system antigens, and acanthocytosis. In some allelic variants, elevated creatine kinase, myopathy, neurogenic muscle atrophy, and progressive chorea are found. We describe a family with a novel point mutation in the XK gene consisting of a C to T base transition at nucleotide position 977, introducing a stop codon. Among seven affected males, five manifested with psychiatric disorders such as depression, bipolar disorder, or personality disorder, but only two presented with chorea Positron emission tomography and magnetic resonance volumetry revealed reduced striatal 2-fluoro-2-deoxy-glucose (FDG) uptake and diminished volumes of the caudate nucleus and putamen that correlated with disease duration. In contrast, none of 12 female mutation carriers showed psychiatric or movement disorders. However, a semidominant effect of the mutation was suggested by erythrocyte and blood group mosaicism and reduced striatal FDG uptake without structural abnormalities. Therefore, patients with psychiatric signs or symptoms segregating in an X-linked trait should be examined for acanthocytosis and Kell/Kx blood group serology. 
 Question: Mutation of which gene is associated with McLeod syndrome?
Output: xk
Context: Kermit Smith, Jr. (June 7, 1957 -- January 24, 1995) was executed by the state of North Carolina for the kidnap, rape, and murder of a 20-year-old college cheerleader. 
 Question: Which crime led to the conviction of Kermit Smith, Jr.?
Output: murder
Context: On June 5, 1981 the Centers for Disease Control in Atlanta, U.S. announced the presence of a rare, infectious disease in five American homosexuals . Soon doctors were finding similar cases all over the country and the world. The AIDS epidemic had officially begun. By 1983 it was clear that AIDS had spread around the world. More than twenty years later, AIDS has left twenty-six million dead and another forty million infected. AIDS has become the worst medical disaster ever experienced by mankind. Hundreds of young people between the ages of 20 and 45 died each week during the early years of the U.S. AIDS. More than 600,000 cases of AIDS have been reported since 1981 in the United States, and it is estimated that there may be as many as 900,000 Americans infected with HIV. Though the rate of HIV infections continues to increase in the United States, the number of AIDS cases has fallen sharply since 1996, when antiretroviral drugs came onto the market. Unfortunately, the AIDS epidemic continues today in Africa and much of Asia, where antiretroviral treatment is not available and health care is far from enough. AIDS is the fourth leading cause of death worldwide, and the No. 1 cause of death due to infectious disease. HIV, the virus that causes AIDS, was first separated in 1983 by a team at the Pasteur Institute in Paris. That discovery made it possible to develop a test for AIDS and trace back to victims who may have died before doctors were aware of the disease. However, scientists still don't know exactly how and where AIDS started. Finding the source of AIDS could be important in developing a vaccine and be important in mapping the future course of the epidemic. 
 Question: Which areas are the most worrying places where AIDS spreads quickly?
Output: africa.
Context: The Garte is a small tributary to the Leine River in Lower Saxony, Germany. 
 Question: What is Garte a tributary of?
Output: leine
Context: Caribbean Airlines Limited, headquartered in Piarco, Trinidad and Tobago, had administrative offices for Air Jamaica located at Norman Manley International Airport in Kingston, Jamaica. 
 Question: What airport is Air Jamaica part of?
Output: norman manley international airport
Context: Majda Mehmedovic (born 25 May 1990) is a Montenegrin handball player. 
 Question: What is Majda Mehmedovic's sport of choice?
Output: handball
Context: Jean-Francois Domergue (born 23 June 1957) is a former French footballer who played defender. 
 Question: In what capacity did Jean-Francois Domergue play football?
Output: defender
Context: Energy travels through space or material. This is obvious when you stand near a fire and feel its warmth or when you pick up the handle of a metal pot even though the handle is not sitting directly on the hot stove. Invisible energy waves can travel through air, glass, and even the vacuum of outer space. These waves have electrical and magnetic properties, so they are called electromagnetic waves. The transfer of energy from one object to another through electromagnetic waves is known as radiation. Different wavelengths of energy create different types of electromagnetic waves (Figure 1.1). The wavelengths humans can see are known as visible light. When viewed together, all of the wavelengths of visible light appear white. But a prism or water droplets can break the white light into different wavelengths so that separate colors appear (Figure 1.2). What objects can you think of that radiate visible light? Two include the Sun and a light bulb. The longest wavelengths of visible light appear red. Infrared wavelengths are longer than visible red. Snakes can see infrared energy. We feel infrared energy as heat. Wavelengths that are shorter than violet are called ultraviolet. Can you think of some objects that appear to radiate visible light, but actually do not? The Moon and the planets do not emit light of their own; they reflect the light of the Sun. Reflection is when light (or another wave) bounces back from a surface. Albedo is a measure of how well a surface reflects light. A surface with high albedo reflects a large percentage of light. A snow field has high albedo. One important fact to remember is that energy cannot be created or destroyed it can only be changed from one form to another. This is such a fundamental fact of nature that it is a law: the law of conservation of energy. In photosynthesis, for example, plants convert solar energy into chemical energy that they can use. They do not create new energy. When energy is transformed, some nearly always becomes heat. Heat transfers between materials easily, from warmer objects to cooler ones. If no more heat is added, eventually all of a material will reach the same temperature. 
 Question: which two items radiate energy?
Output: the sun and a light bulb
Context: Rosemary's Billygoat is an American heavy metal/hard rock band formed in Los Angeles ' South Bay in 1991, consisting of singer Mike Odd, guitarist Neal Gargantua, bassist Pat Trick and drummer Paul Bearer. 
 Question: The year that Rosemary's Billygoat was created was?
Output: 1991
Context: In Week 8, the Bears donned their 1940s throwback uniforms against the Carolina Panthers, who had the worst record in the NFC. The Bears scored first on Matt Forte's 13-yard touchdown run, which would be countered by Justin Medlock's 34-yard field goal. The Panthers then took the lead on Louis Murphy's fumble recovery; Panthers quarterback Cam Newton ran with the ball, and lost the ball when Bears safety Major Wright tackled him at the 1-yard line. The ball rolled into the endzone, where Murphy recovered it. Medlock would then kick three more field goals, and by the fourth quarter, the Panthers led 19-7. The tide eventually turned when Panthers punter Brad Nortman shanked a 6-yard punt, and Jay Cutler hit Kellen Davis on a 12-yard touchdown pass with less than seven minutes left in the game. On the first play of the Panthers' next drive, Tim Jennings intercepted Newton and returned the pick 25 yards to regain the lead 20-19, after Cutler's two-point conversion passing attempt was intercepted. Medlock later kicked another field goal to reclaim the lead 22-20 with 2:27 left in the game. Cutler would lead the Bears downfield, and Gould kicked a 41-yard field goal as time expired to give Chicago the victory. The kick was Gould's tenth game-winning field goal, and the first since 2010. 
 Question: Which player scored the first touchdown of the game?
Output: matt forte
Context: If you are a traditional traveller who believes cameras are irreplaceable,here are some things you should pay attention to when looking for the perfect camera. Sensor size Along with the megapixel count,the size of the sensor dictates the general image quality as well as the camera's performance in low light. It also determines whether the camera can electronically put the details it captures bigger enough to see--which is what makes the pictures not clear enough to see when you view the photos on a bigger screen. Portability "The important thing is that the camera isn't too big or heavy,and that you have a good zoom range for both wide-angle and telephoto shots ,"Atherton told CNN.A good choice would be a slim,light pocket camera with a high-qualified built-in optical zoom. "These are very popular for travel as they are light,but built with a telephoto lens that can zoom up to 60 times," Atherton said. Zoom and shutter speed For action or crowd shots,a fast shutter speed is a key factor. "When dealing with anything that's active--wildlife or people in action on the street--faces change within a tiny part of a second," said Arnold,"a fast shutter speed is helpful in shooting the several hundred photos you might need to get that single winning shot." 
 Question: What will contribute to a satisfactory photo of a running lion in the wild?
Output: the shutter speed.
Context: For each vintage, the CIVC rated the villages of the area based on the quality of their grapes and vineyards. The rating was then used to determine the price and the percentage of the price that growers get. The Grand Cru rated vineyards received 100 percent rating which entitled the grower to 100% of the price. Premier Crus were vineyards with 9099% ratings while Deuxieme Crus received 8089% ratings. Under appellation rules, around 4,000 kilograms (8,800 pounds) of grapes can be pressed (wine) to create up to 673 gallons (US) (either 2,550 L or 3,060 L) of juice. The first 541 gallons (either 2,050 L or 2,460 L) are the cuvee and the next 132 gallons (either 500 L or 600 L) are the taille. Prior to 1992, a second taille of 44 gallons (either 167 L or 200 L) was previously allowed. For vintage Champagne, 100% of the grapes must come from that vintage year while non-vintage wine is a blend of vintages. Vintage champagne must spend a minimum of three years of aging. There are no regulations about how long it must spend on its Lees (fermentation), but some of the premier Champagne houses keep their wines on Lees (fermentation) for upwards of five to ten years. Non-vintage Champagne must spend a minimum of 15 months of aging but only a minimum of 12 months on the lees. Most of the Champagne houses keep their wines on the lees through the whole time of aging because it is more expense to bottle the wine then age it and finally shipped. 
 Question: What is the taille?
Output: the next 132 gallons
Context: Hurry! Time to "steal vegetables" Don't be afraid! We are not encouraging the stealing behavior, but to tell you maybe the most popular topic from white-collars' mouth in cities. Together with "How many vegetables do you steal today," "it's harvest time for your ripe peach," "I bought you a new car today." Are there so many people in the city really have their own farms, or are they really so rich to buy someone else cars casually? The answer is obviously negative. They just play some games on Social Network Sites (SNS) like kaixin001.com. Can you imagine that more than millions of people in Chinese mainland will spend lots of time on SNS to play game and talk to friends, especially white-collars who work in the cities? Take kaixin001.com as an example, the current member of it has already hit 38 million. However, the great number of people who would like to use such SNS indicates another social problem. That is lots of people choose to escape from the reality. And SNS just offer them a Virtual space to forget the reality. Kinds of games and various of friends do give netizens lots of fun. Though indulging, dreaming, chatting and playing , it seems like people could really escape from all the upsets in reality. But virtual world is not real and no one can live in it forever, and reality is not that simple like noodling around on the internet. Since this kind of social phenomenon is so popular on the internet, people start thinking to remove it in the reality.After playing the "happy farm" game on kaixin001.com, would you like to put yourself among the real corps while smelling the fragrance of the countryside? Recently, a farm land service called "happy farm in reality" was opened in the suburbs of Shanghai where white-collar workers from around that region can experience the real farmer's life by themselves 
 Question: Which group are the majority playing the "Happy Farm" game?
Output: white-collars
Context: Penguins of Madagascar is a 2014 American 3D computer-animated action comedy adventure film, produced by DreamWorks Animation and distributed by 20th Century Fox. 
 Question: What production company or companies created Penguins of Madagascar?
Output: dreamworks animation
Context: Riociguat (Adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. 
 Question: What is generic name of drug Adempas?
Output: riociguat
Context: During the war, the Russian army organized the Crimean campaigns of 1687 and 1689 both which ended in Russian defeats. Despite these setbacks, Russia launched the Azov campaigns in 1695 and 1696, and after raising the siege in 1695 successfully occupied Azov in 1696. 
 Question: who lost the Crimean Campaigns?
Output: russia
Context: In 2009 Fukushimas industries directly employed 18,678 workers and shipped 671 billion worth of goods. This was led by information-related industries with 50.5% of total output. Other industries in Fukushima include those dealing with food at 7.6% of total output, metals at 7.5%, chemistry at 5.3%, ceramics at 4.9%, electricity at 4.5%, printed goods at 2.8%, steel at 2.5%, plastics at 2.5%, and electronics at 2.2%. Other various industries make up the final 9.8%. 
 Question: What industry made up the smalled percentage?
Output: electronics
Context: Motilal Nehru (6 May 1861 -- 6 February 1931) was an Indian lawyer, an activist of the Indian National Movement and an important leader of the Indian National Congress, who also served as the Congress President twice, 1919--1920 and 1928--1929. 
 Question: Which political party was Motilal Nehru a member of?
Output: indian national congress
Context: The Mavericks finished 49-33, one game ahead of Phoenix for the eighth and final playoff spot, which meant that they would once again have to face their in-state rivals, the San Antonio Spurs, who were the top seed in the Western Conference with a 62-20 record. In Game 1 in San Antonio, Dallas had an 81-71 lead in the fourth quarter, but the Spurs rallied back and took Game 1, 85-90. However, the Mavs forced 22 turnovers in Game 2 to rout the Spurs 113-92, splitting the first two games before the series went to Dallas. In Game 3, Manu Ginobili hit a shot that put the Spurs up 108-106 with 1.7 seconds left, but a buzzer-beater by Vince Carter gave the Mavs the victory, putting them up 2-1 in the series. The Spurs took Game 4 in Dallas 93-89 despite a late Dallas comeback after the Spurs at one point had a 20-point lead and later won Game 5 at home, 109-103, giving them a 3-2 series lead. The Mavs avoided elimination in Game 6 at home by rallying in the fourth quarter, winning 111-113. Game 7 was on the Spurs home court, and the Spurs beat the Mavericks 119-96, putting an end to the Mavericks season. 
 Question: Which team won the playoffs, the Mavericks or the Spurs?
Output: he spurs
Context: The Mavericks finished 49-33, one game ahead of Phoenix for the eighth and final playoff spot, which meant that they would once again have to face their in-state rivals, the San Antonio Spurs, who were the top seed in the Western Conference with a 62-20 record. In Game 1 in San Antonio, Dallas had an 81-71 lead in the fourth quarter, but the Spurs rallied back and took Game 1, 85-90. However, the Mavs forced 22 turnovers in Game 2 to rout the Spurs 113-92, splitting the first two games before the series went to Dallas. In Game 3, Manu Ginobili hit a shot that put the Spurs up 108-106 with 1.7 seconds left, but a buzzer-beater by Vince Carter gave the Mavs the victory, putting them up 2-1 in the series. The Spurs took Game 4 in Dallas 93-89 despite a late Dallas comeback after the Spurs at one point had a 20-point lead and later won Game 5 at home, 109-103, giving them a 3-2 series lead. The Mavs avoided elimination in Game 6 at home by rallying in the fourth quarter, winning 111-113. Game 7 was on the Spurs home court, and the Spurs beat the Mavericks 119-96, putting an end to the Mavericks season. 
 Question: Which team won the playoffs, the Mavericks or the Spurs?
Output: spurs
Context: Neuronal loss in specific brain regions and neurons with intracellular inclusions termed Lewy bodies are the pathologic hallmark in both Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Lewy bodies comprise of aggregated intracellular vesicles and proteins and -synuclein is reported to be a major protein component. Using human brain tissue from control, PD and DLB and light and confocal immunohistochemistry with antibodies to superoxide dismutase 2 as a marker for mitochondria, -synuclein for Lewy bodies and III Tubulin for microtubules we have examined the relationship between Lewy bodies and mitochondrial loss. We have shown microtubule regression and mitochondrial and nuclear degradation in neurons with developing Lewy bodies. In PD, multiple Lewy bodies were often observed with -synuclein interacting with DNA to cause marked nuclear degradation. In DLB, the mitochondria are drawn into the Lewy body and the mitochondrial integrity is lost. This work suggests that Lewy bodies are cytotoxic. In DLB, we suggest that microtubule regression and mitochondrial loss results in decreased cellular energy and axonal transport that leads to cell death. In PD, -synuclein aggregations are associated with intact mitochondria but interacts with and causes nuclear degradation which may be the major cause of cell death. 
 Question: Which is the primary protein component of Lewy bodies?
Output: αsyn
Context: Neuronal loss in specific brain regions and neurons with intracellular inclusions termed Lewy bodies are the pathologic hallmark in both Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Lewy bodies comprise of aggregated intracellular vesicles and proteins and -synuclein is reported to be a major protein component. Using human brain tissue from control, PD and DLB and light and confocal immunohistochemistry with antibodies to superoxide dismutase 2 as a marker for mitochondria, -synuclein for Lewy bodies and III Tubulin for microtubules we have examined the relationship between Lewy bodies and mitochondrial loss. We have shown microtubule regression and mitochondrial and nuclear degradation in neurons with developing Lewy bodies. In PD, multiple Lewy bodies were often observed with -synuclein interacting with DNA to cause marked nuclear degradation. In DLB, the mitochondria are drawn into the Lewy body and the mitochondrial integrity is lost. This work suggests that Lewy bodies are cytotoxic. In DLB, we suggest that microtubule regression and mitochondrial loss results in decreased cellular energy and axonal transport that leads to cell death. In PD, -synuclein aggregations are associated with intact mitochondria but interacts with and causes nuclear degradation which may be the major cause of cell death. 
 Question: Which is the primary protein component of Lewy bodies?
Output: α-synuclein
Context: Neuronal loss in specific brain regions and neurons with intracellular inclusions termed Lewy bodies are the pathologic hallmark in both Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Lewy bodies comprise of aggregated intracellular vesicles and proteins and -synuclein is reported to be a major protein component. Using human brain tissue from control, PD and DLB and light and confocal immunohistochemistry with antibodies to superoxide dismutase 2 as a marker for mitochondria, -synuclein for Lewy bodies and III Tubulin for microtubules we have examined the relationship between Lewy bodies and mitochondrial loss. We have shown microtubule regression and mitochondrial and nuclear degradation in neurons with developing Lewy bodies. In PD, multiple Lewy bodies were often observed with -synuclein interacting with DNA to cause marked nuclear degradation. In DLB, the mitochondria are drawn into the Lewy body and the mitochondrial integrity is lost. This work suggests that Lewy bodies are cytotoxic. In DLB, we suggest that microtubule regression and mitochondrial loss results in decreased cellular energy and axonal transport that leads to cell death. In PD, -synuclein aggregations are associated with intact mitochondria but interacts with and causes nuclear degradation which may be the major cause of cell death. 
 Question: Which is the primary protein component of Lewy bodies?
Output: alpha-synuclein
Context: As of the census of 2000, there were 325,957 people, 149,937 households, and 94,460 families residing in the county. The population density was 570 people per square mile (220/km2). There were 182,467 housing units at an average density of 319 per square mile (123/km2). The racial makeup of the county was 92.65% Race (United States Census), 4.18% Race (United States Census) or Race (United States Census), 0.22% Race (United States Census), 0.77% Race (United States Census), 0.03% Race (United States Census), 1.14% from Race (United States Census), and 1.02% from two or more races. 4.34% of the population were Race (United States Census) or Race (United States Census) of any race. 89.7% spoke only English language at home; 4.4% spoke Spanish language, 1.3% German language, and 1.0% French language at home. 
 Question: Which group is larger according to the census: people or families?
Output: people
Context: SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A-Like 1), also known as HARP, is an ATP-dependent annealing helicase that stabilizes replication forks during DNA damage. Mutations in this gene are the cause of Schimke immune-osseous dysplasia (SIOD), an autosomal recessive disorder characterized by T-cell immunodeficiency and growth dysfunctions. In this review, we summarize the main roles of SMARCAL1 in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. 
 Question: Mutations in which gene cause Schimke immune-osseous dysplasia?
Output: harp
Context: SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A-Like 1), also known as HARP, is an ATP-dependent annealing helicase that stabilizes replication forks during DNA damage. Mutations in this gene are the cause of Schimke immune-osseous dysplasia (SIOD), an autosomal recessive disorder characterized by T-cell immunodeficiency and growth dysfunctions. In this review, we summarize the main roles of SMARCAL1 in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. 
 Question: Mutations in which gene cause Schimke immune-osseous dysplasia?
Output: smarcal1 (swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1)
Context: In the mean time, Maha Nawrahta opened the southern front on 23 October 1765 in three directions. He had 20,000 to 30,000 under his command. A small army invaded by the Three Pagodas Pass towards Suphanburi. Another small army invaded down the Tenasserim coast towards Mergui and Tenasserim town. However, the main thrust of his attack was at Kanchanaburi. His 20,000-strong main southern army invaded via the Myitta Pass. Kanchanaburi fell with little resistance. The main reason for the quick fall of Kanchanaburi could be that the Burmese were more battle-hardened. But it could also be that the Siamese command miscalculated where the Burmese main attack would come from, and had not sufficiently reinforced the fort to withstand a major attack. Judging by the Siamese chronicles' reporting of the main attack route, the Siamese command appeared to have believed that the main Burmese attack would come from the Gulf of Siam coastline, instead of the most obvious and shortest route via Kanchanaburi. The Siamese sources say that Maha Nawrahta's main invasion route came from southern Tenasserim, crossing the Tenasserim range at Chumphon and Phetburi. The path is totally different from the Kanchanaburi route reported by the Burmese chronicles. Historian Kyaw Thet specifically adds that the main attack route was via the Myitta Pass. 
 Question: Who populated the city of Kanchanaburi?
Output: the siamese
Context: Camp Jano India Celebrate Indian culture, languages, arts, festivals and literature. Weekly themes are brought to life through related arts, games, projects, stories and theatre in a very unique, exciting, creative, interactive and structured style. A very unique and memorable experience that kids will want to repeat! Mornings are spent with the Hindi language at the child's level. Afternoons provide the cultural elements taught in an interactive style with special emphasis on drama. Bay Language Academy We invite campers (4-12 years old) to travel and open up doors to explore past and recent civilizations through daily field trips. Cultures will be shown through customs and cooking. Lectures (6/10-8/30) will introduce/reinforce French, Spanish or Chinese and the cultures they convey. Our language summer-camp is infused with cultural activities and taught by a team of bilingual instructors. Petits Confettis Want your 3- to 5-year-old kids to experience a French camp? Come and join us for 6 weeks of French camps! Kids will be totally happy to learn French and French culture while they take part in team projects like building a tipi or making French bread. Weekly themes include cooking, arts, drama, outdoor activities, board games, music, yoga, rhymes and story time. Chinese Immersion Summer Camp This is our 11th Chinese language and culture summer camp. We take children from 6th grade. This year we continue the weekly fun themes like art, science, cooking and sports in the morning. In the afternoon, we have abacus, reading and Chinese culture lessons taught in Chinese. Our teachers are all native speakers with a lot of experience. Our weekly field trips go to different places like SF zoo, tech museums, fire stations etc. 
 Question: What is the common theme of the four camps?
Output: language and culture.
Context: Not everyone had the same warning the people on Tillys beach had. The Boxing Day Tsunami of December 26, 2004 was by far the deadliest of all time (Figure 1.1). The tsunami was caused by the 2004 Indian Ocean Earthquake. With a magnitude of 9.2, it was the second largest earthquake ever recorded. The extreme movement of the crust displaced trillions of tons of water along the entire length of the rupture. Several tsunami waves were created with about 30 minutes between the peaks of each one. The waves that struck nearby Sumatra 15 minutes after the quake reached more than 10 meters (33 feet) in height. The size of the waves decreased with distance from the earthquake and were about 4 meters (13 feet) high in Somalia. The tsunami did so much damage because it traveled throughout the Indian Ocean. About 230,000 people died in eight countries. There were fatalities even as far away as South Africa, nearly 8,000 kilometers (5,000 miles) from the earthquake epicenter. More than 1.2 million people lost their homes and many more lost their ways of making a living. The countries that were most affected by the 2004 Boxing Day tsunami. The Japanese received a one-two punch in March 2011. The 2011 Tohoku earthquake offshore was a magnitude 9.0 and damage from the quake was extensive. People didnt have time to recover before massive tsunami waves hit the island nation. As seen in Figure 1.2, waves in some regions topped 9 meters (27 feet). The tsunami did much more damage than the massive earthquake (Figure 1.3). Worst was the damage done to nuclear power plants along the northeastern coast. Eleven reactors were automatically shut down. Power and backup power were lost at the Fukushima plant, leading to equipment failures, meltdowns, and the release of radioactive materials. Control and cleanup of the disabled plants will go on for many years. As a result of the 2004 tsunami, an Indian Ocean warning system was put into operation in June 2006. Prior to 2004, no one had thought a large tsunami was possible in the Indian Ocean. In comparison, a warning system has been in effect around the Pacific Ocean for more than 50 years. The system was used to warn of possible tsunami waves after the Tohoku earthquake, but most were too close to the quake to get to high ground in time. Further away, people were evacuated along many Pacific coastlines, but the waves were not that large. 
 Question: the 2004 boxing day tsunami killed people all around this ocean basin
Output: indian ocean
Context: The reactive oxygen-generating NADPH oxidases (Noxes) function in a variety of biological roles, and can be broadly classified into those that are regulated by subunit interactions and those that are regulated by calcium. The prototypical subunit-regulated Nox, Nox2, is the membrane-associated catalytic subunit of the phagocyte NADPH-oxidase. Nox2 forms a heterodimer with the integral membrane protein, p22phox, and this heterodimer binds to the regulatory subunits p47phox, p67phox, p40phox and the small GTPase Rac, triggering superoxide generation. Nox-organizer protein 1 (NOXO1) and Nox-activator 1 (NOXA1), respective homologs of p47phox and p67phox, together with p22phox and Rac, activate Nox1, a non-phagocytic homolog of Nox2. NOXO1 and p22phox also regulate Nox3, whereas Nox4 requires only p22phox. In this study, we have assembled and analyzed amino acid sequences of Nox regulatory subunit orthologs from vertebrates, a urochordate, an echinoderm, a mollusc, a cnidarian, a choanoflagellate, fungi and a slime mold amoeba to investigate the evolutionary history of these subunits. Ancestral p47phox, p67phox, and p22phox genes are broadly seen in the metazoa, except for the ecdysozoans. The choanoflagellate Monosiga brevicollis, the unicellular organism that is the closest relatives of multicellular animals, encodes early prototypes of p22phox, p47phox as well as the earliest known Nox2-like ancestor of the Nox1-3 subfamily. p67phox- and p47phox-like genes are seen in the sea urchin Strongylocentrotus purpuratus and the limpet Lottia gigantea that also possess Nox2-like co-orthologs of vertebrate Nox1-3. Duplication of primordial p47phox and p67phox genes occurred in vertebrates, with the duplicated branches evolving into NOXO1 and NOXA1. Analysis of characteristic domains of regulatory subunits suggests a novel view of the evolution of Nox: in fish, p40phox participated in regulating both Nox1 and Nox2, but after the appearance of mammals, Nox1 (but not Nox2) became independent of p40phox. In the fish Oryzias latipes, a NOXO1 ortholog retains an autoinhibitory region that is characteristic of mammalian p47phox, and this was subsequently lost from NOXO1 in later vertebrates. Detailed amino acid sequence comparisons identified both putative key residues conserved in characteristic domains and previously unidentified conserved regions. Also, candidate organizer/activator proteins in fungi and amoeba are identified and hypothetical activation models are suggested. This is the first report to provide the comprehensive view of the molecular evolution of regulatory subunits for Nox enzymes. This approach provides clues for understanding the evolution of biochemical and physiological functions for regulatory-subunit-dependent Nox enzymes. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nadph oxidase 1
Context: The reactive oxygen-generating NADPH oxidases (Noxes) function in a variety of biological roles, and can be broadly classified into those that are regulated by subunit interactions and those that are regulated by calcium. The prototypical subunit-regulated Nox, Nox2, is the membrane-associated catalytic subunit of the phagocyte NADPH-oxidase. Nox2 forms a heterodimer with the integral membrane protein, p22phox, and this heterodimer binds to the regulatory subunits p47phox, p67phox, p40phox and the small GTPase Rac, triggering superoxide generation. Nox-organizer protein 1 (NOXO1) and Nox-activator 1 (NOXA1), respective homologs of p47phox and p67phox, together with p22phox and Rac, activate Nox1, a non-phagocytic homolog of Nox2. NOXO1 and p22phox also regulate Nox3, whereas Nox4 requires only p22phox. In this study, we have assembled and analyzed amino acid sequences of Nox regulatory subunit orthologs from vertebrates, a urochordate, an echinoderm, a mollusc, a cnidarian, a choanoflagellate, fungi and a slime mold amoeba to investigate the evolutionary history of these subunits. Ancestral p47phox, p67phox, and p22phox genes are broadly seen in the metazoa, except for the ecdysozoans. The choanoflagellate Monosiga brevicollis, the unicellular organism that is the closest relatives of multicellular animals, encodes early prototypes of p22phox, p47phox as well as the earliest known Nox2-like ancestor of the Nox1-3 subfamily. p67phox- and p47phox-like genes are seen in the sea urchin Strongylocentrotus purpuratus and the limpet Lottia gigantea that also possess Nox2-like co-orthologs of vertebrate Nox1-3. Duplication of primordial p47phox and p67phox genes occurred in vertebrates, with the duplicated branches evolving into NOXO1 and NOXA1. Analysis of characteristic domains of regulatory subunits suggests a novel view of the evolution of Nox: in fish, p40phox participated in regulating both Nox1 and Nox2, but after the appearance of mammals, Nox1 (but not Nox2) became independent of p40phox. In the fish Oryzias latipes, a NOXO1 ortholog retains an autoinhibitory region that is characteristic of mammalian p47phox, and this was subsequently lost from NOXO1 in later vertebrates. Detailed amino acid sequence comparisons identified both putative key residues conserved in characteristic domains and previously unidentified conserved regions. Also, candidate organizer/activator proteins in fungi and amoeba are identified and hypothetical activation models are suggested. This is the first report to provide the comprehensive view of the molecular evolution of regulatory subunits for Nox enzymes. This approach provides clues for understanding the evolution of biochemical and physiological functions for regulatory-subunit-dependent Nox enzymes. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nicotinamide adenine dinucleotide phosphate-oxidase 1
Context: The reactive oxygen-generating NADPH oxidases (Noxes) function in a variety of biological roles, and can be broadly classified into those that are regulated by subunit interactions and those that are regulated by calcium. The prototypical subunit-regulated Nox, Nox2, is the membrane-associated catalytic subunit of the phagocyte NADPH-oxidase. Nox2 forms a heterodimer with the integral membrane protein, p22phox, and this heterodimer binds to the regulatory subunits p47phox, p67phox, p40phox and the small GTPase Rac, triggering superoxide generation. Nox-organizer protein 1 (NOXO1) and Nox-activator 1 (NOXA1), respective homologs of p47phox and p67phox, together with p22phox and Rac, activate Nox1, a non-phagocytic homolog of Nox2. NOXO1 and p22phox also regulate Nox3, whereas Nox4 requires only p22phox. In this study, we have assembled and analyzed amino acid sequences of Nox regulatory subunit orthologs from vertebrates, a urochordate, an echinoderm, a mollusc, a cnidarian, a choanoflagellate, fungi and a slime mold amoeba to investigate the evolutionary history of these subunits. Ancestral p47phox, p67phox, and p22phox genes are broadly seen in the metazoa, except for the ecdysozoans. The choanoflagellate Monosiga brevicollis, the unicellular organism that is the closest relatives of multicellular animals, encodes early prototypes of p22phox, p47phox as well as the earliest known Nox2-like ancestor of the Nox1-3 subfamily. p67phox- and p47phox-like genes are seen in the sea urchin Strongylocentrotus purpuratus and the limpet Lottia gigantea that also possess Nox2-like co-orthologs of vertebrate Nox1-3. Duplication of primordial p47phox and p67phox genes occurred in vertebrates, with the duplicated branches evolving into NOXO1 and NOXA1. Analysis of characteristic domains of regulatory subunits suggests a novel view of the evolution of Nox: in fish, p40phox participated in regulating both Nox1 and Nox2, but after the appearance of mammals, Nox1 (but not Nox2) became independent of p40phox. In the fish Oryzias latipes, a NOXO1 ortholog retains an autoinhibitory region that is characteristic of mammalian p47phox, and this was subsequently lost from NOXO1 in later vertebrates. Detailed amino acid sequence comparisons identified both putative key residues conserved in characteristic domains and previously unidentified conserved regions. Also, candidate organizer/activator proteins in fungi and amoeba are identified and hypothetical activation models are suggested. This is the first report to provide the comprehensive view of the molecular evolution of regulatory subunits for Nox enzymes. This approach provides clues for understanding the evolution of biochemical and physiological functions for regulatory-subunit-dependent Nox enzymes. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nox1