niryuu/sni-each-converted huggingface dataset:
Context: Spinocerebellar ataxia type 3 (SCA3) is the most frequent inherited cerebellar ataxia in Europe, the US and Japan, leading to disability and death through motor complications. Although the affected protein ataxin-3 is found ubiquitously in the brain, grey matter atrophy is predominant in the cerebellum and the brainstem. White matter pathology is generally less severe and thought to occur in the brainstem, spinal cord, and cerebellar white matter. Here, we investigated both grey and white matter pathology in a group of 12 SCA3 patients and matched controls. We used voxel-based morphometry for analysis of tissue loss, and tract-based spatial statistics (TBSS) on diffusion magnetic resonance imaging to investigate microstructural pathology. We analysed correlations between microstructural properties of the brain and ataxia severity, as measured by the Scale for the Assessment and Rating of Ataxia (SARA) score. SCA3 patients exhibited significant loss of both grey and white matter in the cerebellar hemispheres, brainstem including pons and in lateral thalamus. On between-group analysis, TBSS detected widespread microstructural white matter pathology in the cerebellum, brainstem, and bilaterally in thalamus and the cerebral hemispheres. Furthermore, fractional anisotropy in a white matter network comprising frontal, thalamic, brainstem and left cerebellar white matter strongly and negatively correlated with SARA ataxia scores. Tractography identified the thalamic white matter thus implicated as belonging to ventrolateral thalamus. Disruption of white matter integrity in patients suffering from SCA3 is more widespread than previously thought. Moreover, our data provide evidence that microstructural white matter changes in SCA3 are strongly related to the clinical severity of ataxia symptoms. 
 Question: Which is the protein implicated in Spinocerebellar ataxia type 3?
Output: ataxin-3
Context: Michael (John Travolta) is not a stereotypical archangel. He epitomizes the freedom that an angel might command if living among mere mortals. As the tagline says, "He's an angel, not a saint."Two reporters, Frank Quinlan (William Hurt) and Huey Driscoll (Robert Pastorelli), one cynical and the other innocent, work for a tabloid newspaper in Chicago. ("Quinlan" is a nod to one of the writers of the same name.) They travel to a sleepy hamlet in Iowa because Quinlan has received a letter from a woman, Pansy Milbank, (Jean Stapleton) who has an angel for tenant and he is able to convince his editor (Bob Hoskins) that they should visit her at the Milk Bottle Motel. She dies before their very eyes, and they "persuade" Michael to accompany them to Chicago. Traveling with them is an alleged angel expert, Dorothy Winters (Andie MacDowell) with whom they were saddled by their editor.Michael is in control of the entire trip. They stop when he says so because he causes their tire to go flat. He leads them in a fight in a bar for which they are jailed one night. And he resurrects the dog, Sparky, after it is runover by a truck.Throughout the story, there is romantic tension between the angel expert and Quinlan, the cynical reporter and Michael engineers their romance to the very end.The movie's climax comes when they finally arrive in Chicago and Michael breathes his last looking up at the Sears Tower. (Michael has a fascination for the biggest and tallest things in the world.) Michael wasn't dying; but he was exiting earth for his last time. Meanwhile, the angel expert is exposed as a spy for the manipulative editor, and she confesses that she was after Huey's job. In truth, she is a dog expert who was sent on the trip to befriend Sparky. Quinlan, who at one point was moving out of his cynicism, regresses and the story almost ends with the three traveling companions going their separate ways, knowing they had journeyed with an angel, but not understanding exactly what it meant.Finally, one night, Quinlan spots a figure that he thinks is Michael (who was lying about it being his last visit), and begins following him rapidly through the streets. He rounds one corner and careens into Dorothy, who apparently was following a Michael-clone herself. Their faith is restored, and their love blossoms once more. "Marry me, Dorothy," says Quinlan. "Yes," she replies. Then the scene freezes, and out pop Michael and Pansy Milbank -- we're left to ponder whether she became an angel when she died earlier, or that she was an angel all along -- and they dance through the frozen people until they merge with the light emanating from a car's headlights. 
 Question: Who owns Sparky the Wonder Dog?
Output: michael
Context: Rachel (Andrea Bowen), a high school girl, seems to have the life that most people envy: she has a steady boyfriend, some great friends, and a place on the school's soccer team. Preparing for college and separating from her boyfriend are the main worries of this teen, as she lives a carefree life like most girls her age. However, Rachel's world falls apart the day she discovers that Jason (Eric von Detton), a former sexual partner of hers that died an untimely death, was in fact HIV positive and an IV drug user. She immediately goes to an AIDS clinic to get a rapid test, which unfortunately comes back positive. Devastated by the fact that she may actually be infected with the virus, Rachel then confides in her substitute teacher, Sarah (Jennie Garth), who has secretly been living with the disease for years. But both young women are about to find out their secrets will not be kept secret for very long, as word begins to spread throughout their high school and rumors fly, making some of these students realize that they may not be as "clean" as they think they are. 
 Question: What sport does Rachel play in high school?
Output: soccer
Context: Hjarnkontoret (''Think Tank'') is a Swedish children's science programme broadcast by SVT since 10 January 1995 (then hosted by Fredrik Berling). 
 Question: What year did Hjarnkontoret start?
Output: 10 january 1995
Context: CHICAGO (AP) On Jan. l,an order went into effect requiring that every checked bag at more than 400 of the nation's commercial airports be screened for bombs and weapons. Sunday was expected to the heaviest travel day since Jan. l. Yet spot checks on Sunday at several of the nation's airports showed no major delays caused by the new security measures. At the international terminal for Northwest Airlines at John F. Kennedy International Airport inprefix = st1 /New York, passengers waited up to 30 minutes longer than usual. Their bags were sent through giant screening machines and workers tore open taped boxes and searched through their contents before closing them up again. Most travelers simply accepted stricter screening developed since the terrorist attacks on Sept. 11,2001,before which only 5 percent of the roughly 2 million bags checked each day were screened for bombs. The U. S. government has put an additional 23,000 people into airports to carry out the new order. Sonny Salgatar, a 23-year-old college student flying home to San Diego fromChicago, was told by an airport officer after the first pass that one of his bags was "hot", meaning there was something he couldn't identify and he wanted to open the bag for an inspection. The "hot" item turned out to be Salgatar's clothing iron. "Listen, anything they want to do for security is OK for me," Salgatar said. But not all of the passengers hold the same viewpoint as Salgatar's, complaining that they had to arrive at the airport too much time ahead of their schedule. 
 Question: The new measure was adopted to guard against.
Output: . terrorist attacks
Context: Robert P. Baldwin (October 19, 1917 -- April 7, 1994) was an Army Air Corps and United States Air Force pilot during World War II and Korea. 
 Question: With which military branch did Robert P. Baldwin hold a command?
Output: united states air force
Context: Darma (Pierre Andre) is traumatised by the mysterious death of his fiancee, Rose (Intan Ladyana) who had killed herself. Unknown to him, Rose had been haunted by a malicious spirit which they had brought to her home after picking up a small jar found washed up at the beach. Apparently, the spirit had been imprisoned and was inadvertently released by the couple.At her home, after her death, before leaving Darma had taken the small jar with him, and with it, the malignant spirit.Not satisfied with why Rose had suddenly killed herself, Darma decides to investigate the case with the help of Rose's twin sister, Seri, (also played by Intan Ladyana). As they probe into the death, a series of strange occurrences start to unravel, leaving Darma in a disturbed state of mind that affects his life and career. When he is advised to take a week's break from work, he returns to his village to rest. Unknown to him, he is only getting closer to solving his fiancee's death and the truth behind the strange happenings.It was Darma's senile grandmother who could see the ghost and had unwittingly invited the spirit into the house. In Malay belief, certain spirits cannot enter the house unless invited in. This is similar to the vampire mythology in the West. The ghost in this movie is called Saka. Saka was a ghost that has been kept by the elder for some uncertified reason. Mostly, Saka starts to give problems when it's owner die and Saka needs to be feed. Mostly, Saka will haunt the next generation of the owner. 
 Question: What is Darma advised to take from work?
Output: a week's break from work
Context: The median income for a household in the county was $32,073, and the median income for a family was $36,999. Males had a median income of $27,346 versus $21,145 for females. The per capita income for the county was $16,830. About 9.60% of families and 13.70% of the population were below the poverty line, including 26.00% of those under age 18 and 7.70% of those age 65 or over. According to The Daily Commercial, Sumter Countys unemployment rate as of March 2009 is 13.2 percent. 
 Question: Which had a higher income, households or families?
Output: family
Context: Rear Admiral James Edward Jouett (7 February 1826 -- 30 September 1902), known as ''Fighting Jim Jouett of the American Navy'', was an officer in the United States Navy during the Mexican-American War and the American Civil War. 
 Question: What conflict involved James Edward Jouett?
Output: american civil war
Context: Recently, bi-allelic mutations in the transcription factor RFX6 were described as the cause of a rare condition characterized by neonatal diabetes with pancreatic and biliary hypoplasia and duodenal/jejunal atresia. A male infant developed severe hyperglycemia (446mg/dL) within 24h of birth. Acute abdominal concerns by day five necessitated exploratory surgery that revealed duodenal atresia, gallbladder agenesis, annular pancreas and intestinal malrotation. He also exhibited chronic diarrhea and feeding intolerance, cholestatic jaundice, and subsequent liver failure. He died of sepsis at four months old while awaiting liver transplantation. The phenotype of neonatal diabetes with intestinal atresia and biliary agenesis clearly pointed to RFX6 as the causative gene; indeed, whole exome sequencing revealed a novel homozygous RFX6 mutation c.779A>C; p.Lys260Thr (K260T). This missense mutation also changes the consensus 5' splice donor site before intron 7 and is thus predicted to cause disruption in splicing. Both parents, who were not known to be related, were heterozygous carriers. Targeted genetic testing based on consideration of phenotypic features may reveal a cause among the many genes now associated with heterogeneous forms of monogenic neonatal diabetes. Our study demonstrates the feasibility of using modern sequencing technology to identify one such rare cause. Continued research is needed to determine the possible cost-effectiveness of this approach, especially when clear phenotypic clues are absent. Further study of patients with RFX6 mutations should clarify its role in pancreatic, intestinal and enteroendocrine cellular development and explain features such as the diarrhea exhibited in our case. 
 Question: Which gene is associated with the Mitchell-Riley syndrome?
Output: rfx6
Context: To analyze the relationship between the type I interferon (IFN) signature and clinical response to rituximab in rheumatoid arthritis (RA) patients. Twenty RA patients were treated with rituximab (cohort 1). Clinical response was defined as a decrease in the Disease Activity Score evaluated in 28 joints (DAS28) and as a response according to the European League Against Rheumatism (EULAR) criteria at week 12 and week 24. The presence of an IFN signature was analyzed in peripheral blood mononuclear cells by measuring the expression levels of 3 IFN response genes by quantitative polymerase chain reaction analysis. After comparison with the findings in healthy controls, patients were classified as having an IFN high or an IFN low signature. The data were confirmed in a second independent cohort (n = 31). Serum IFN bioactivity was analyzed using a reporter assay. In cohort 1, there was a better clinical response to rituximab in the IFN low signature group. Consistent with these findings, patients with an IFN low signature had a significantly greater reduction in the DAS28 and more often achieved a EULAR response at weeks 12 and 24 as compared with the patients with an IFN high signature in cohort 2 versus cohort 1. The pooled data showed a significantly stronger decrease in the DAS28 in IFN low signature patients at weeks 12 and 24 as compared with the IFN high signature group and a more frequent EULAR response at week 12. Accordingly, serum IFN bioactivity at baseline was inversely associated with the clinical response, although this result did not reach statistical significance. The type I IFN signature negatively predicts the clinical response to rituximab treatment in patients with RA. This finding supports the notion that IFN signaling plays a role in the immunopathology of RA. 
 Question: Which is the most common gene signature in Rheumatoid Arthritis patients?
Output: ifn signature
Context: To analyze the relationship between the type I interferon (IFN) signature and clinical response to rituximab in rheumatoid arthritis (RA) patients. Twenty RA patients were treated with rituximab (cohort 1). Clinical response was defined as a decrease in the Disease Activity Score evaluated in 28 joints (DAS28) and as a response according to the European League Against Rheumatism (EULAR) criteria at week 12 and week 24. The presence of an IFN signature was analyzed in peripheral blood mononuclear cells by measuring the expression levels of 3 IFN response genes by quantitative polymerase chain reaction analysis. After comparison with the findings in healthy controls, patients were classified as having an IFN high or an IFN low signature. The data were confirmed in a second independent cohort (n = 31). Serum IFN bioactivity was analyzed using a reporter assay. In cohort 1, there was a better clinical response to rituximab in the IFN low signature group. Consistent with these findings, patients with an IFN low signature had a significantly greater reduction in the DAS28 and more often achieved a EULAR response at weeks 12 and 24 as compared with the patients with an IFN high signature in cohort 2 versus cohort 1. The pooled data showed a significantly stronger decrease in the DAS28 in IFN low signature patients at weeks 12 and 24 as compared with the IFN high signature group and a more frequent EULAR response at week 12. Accordingly, serum IFN bioactivity at baseline was inversely associated with the clinical response, although this result did not reach statistical significance. The type I IFN signature negatively predicts the clinical response to rituximab treatment in patients with RA. This finding supports the notion that IFN signaling plays a role in the immunopathology of RA. 
 Question: Which is the most common gene signature in Rheumatoid Arthritis patients?
Output: interferon signature
Context: A personal journey into the heart of the Killing FieldsOne of the most harrowing and compelling personal documentaries of our time, ENEMIES OF THE PEOPLE exposes for the first time the truth about the Killing Fields and the Khmer Rouge who were behind Cambodias horrific genocide. More than simply an inquiry into Cambodias experience, however, ENEMIES OF THE PEOPLE is a profound meditation on the nature of good and evil, shedding light on the capacity of some people to do terrible things and for others to forgive them.Winner of a dozen top documentary festival awards, including a Special Jury Prize at Sundance and the Grand Jury Award at the Full Frame Documentary Festival, this is a riveting film that takes audiences as close to witnessing evil as they are ever likely to get. It is also a personal journey into the heart of darkness by journalist/filmmaker Thet Sambath, whose family was wiped out in the Killing Fields, but whose patience and discipline elicits unprecedented on-camera confessions from perpetrators at all levels of the Khmer Rouge hierarchy. This is investigative journalism of the highest order.In 1974, Thet Sambaths father became one of the nearly two million people who were murdered by the Khmer Rouge when he refused to give them his buffalo. Sambaths mother was forced to marry a Khmer Rouge militiaman and died in childbirth in 1976, while his eldest brother disappeared in 1977. Sambath himself escaped Cambodia at age 10 when the Khmer Rouge fell in 1979.Fast forward to 1998, and Sambath, now a journalist, got to know the children of some senior Khmer Rouge cadre and gradually earned their trust. Then, for a decade, he spent weekends visiting the home of the most senior surviving leader, Nuon Chea, aka Brother Number Two under Pol Pot. But he never used to say anything different from what he told Western journalists, says Sambath, I was low-ranking, I knew nothing, I am not a killer. Then one day he said to me Sambath, I trust you, you are the person I would like to tell my story to. Ask me what you want to know. For the next five years he told me the truth, as he saw it, including all the details of killing.Sambath also won the confidence of lower-level Khmer Rouge soldiers, now ordinary fathers and grandfathers, who demonstrated to him how they slit peoples throats. For these murderers, it was the first time they admitted what they had done. He taped their interactions and discussions about the killings, and together with British documentarian Rob Lemkin they created this landmark film.For Sambath, it has been an ongoing, lifelong personal journey to discover what was behind such horror; he neglected both his family and his own happiness in the search for truth with hope of reconciliation. ENEMIES OF THE PEOPLE is at once a cinematically beautiful, chillingly insightful, and deeply personal piece of documentary filmmaking. 
 Question: How many Cambodians died during the rule of Khmer Rouge?
Output: nearly two million
Context: Week 8 saw the Bears return to Soldier Field to play the San Francisco 49ers. Prior to the game, Lovie Smith announced that the Bears would don their alternative orange jerseys to commemorate the upcoming Halloween holiday, and asked Bear fans to wear orange clothing to create an "orange swarm" at Soldier Field. The Bears' 41 point first half tied the franchise record for most points scored in one half, the other game being the 1940 NFL Championship, where the Bears defeated the Washington Redskins 73-0. 
 Question: How many points did the Bears have at halftime?
Output: 41 point
Context: In the previous study, we generated a rat model of dilated cardiomyopathy (DCM) induced by adriamycin and found that the expression of lncRNA H19 was significantly upregulated in myocardial tissue. The present study was aimed to investigate the potential role of H19 in the pathogenesis of adriamycin-induced DCM. H19 knockdown in the myocardium of DCM rats attenuated cardiomyocyte apoptosis and improved left ventricular structure and function. Adriamycin treatment was associated with elevated H19 and miR-675 expression and increased apoptosis in neonatal cardiomyocytes. Enforced expression of miR-675 was found to induce apoptosis in cardiomyocytes with adriamycin treatment and H19-siRNA transfection. The 3'-untranslated region of PA2G4 was cloned downstream of a luciferase reporter construct and cotransfected into HEK293 cells with miR-675 mimic. The results of luciferase assay showed that PA2G4 was a direct target of miR-675. The expression of PA2G4 was reduced in cardiomyocytes transfected with miR-675 mimic. Moreover, H19 knockdown was found to increase PA2G4 expression and suppress apoptosis in cardiomyocytes exposed to adriamycin. In conclusion, our study suggests that H19/miR-675 axis is involved in the promotion of cardiomyocyte apoptosis by targeting PA2G4, which may provide a new therapeutic strategy for the treatment of adriamycin-induced DCM. 
 Question: Name an lncRNA associated with dilated cardiomyopathy.
Output: lncrna h19
Context: Chopiatyn (xwpjatn) is a village in the administrative district of Gmina Dohobyczow, within Hrubieszow County, Lublin Voivodeship, in eastern Poland, close to the border with Ukraine. 
 Question: With which country would you associate Chopiatyn?
Output: poland
Context: The study of cancer predisposition syndromes presents unique opportunities to gain insights into the genetic events associated with tumor pathogenesis. Individuals with two inherited cancer syndromes, neurofibromatosis 1 (NF1) and neurofibromatosis 2 (NF2), develop both benign and malignant tumors. The corresponding genes mutated in these two disorders encode tumor suppressor proteins, termed neurofibromin (NF1) and merlin (NF2), which function in novel ways to regulate cell growth and differentiation. Neurofibromin inhibits cell proliferation, at least in part, by modulating mitogenic pathway signaling through inactivation of p21-ras. In contrast, merlin may act as a membrane-associated molecular switch that regulates cell-cell and cell-matrix signals transduced by cell surface receptors. Significant progress in our understanding of the genetics and biology of NF1 and NF2 has elucidated the roles of these genes in tumor initiation and progression. 
 Question: Which is the gene mutated in type 1 neurofibromatosis?
Output: nf1
Context: The median income for a household in the city in 2000 was $29,378 (2010$37,436), and the median income for a family was $41,158. Males had a median income of $32,929 versus $26,856 for females. The per capita income for the city was $17,076. About 20.2% of families and 25.9% of the population were below the poverty line, including 41.5% of those under age 18 and 5.6% of those age 65 or over. 
 Question: Which age group had more people living below the poverty line, those under age 18 or those age 65 or over?
Output: under age 18
Context: Vexillum malleopunctum is a species of small sea snail, marine gastropod mollusk in the family Costellariidae, the ribbed miters. 
 Question: Is Vexillum malleopunctum a genus or species?
Output: species
Context: Acrokeratosis paraneoplastica of Bazex is a rare cutaneous syndrome associated with malignant neoplasms of the pulmonary and upper gastrointestinal tract, or cervical metastatic adenopathy, usually seen in middle-aged white men. We present a unique case of Bazex syndrome in that the patient was young, black, and a woman. 
 Question: Name synonym of Acrokeratosis paraneoplastica.
Output: bazex syndrome
Context: There have been several milestones in the Paralympic movement. The first official Paralympic Games, no longer open solely to war veterans, was held in Rome in 1960 Summer Paralympics. 400 athletes from 23 countries competed at the 1960 Games. Since 1960, the Paralympic Games have taken place in the same year as the Olympic Games. The Games were initially open only to athletes in wheelchairs; at the 1976 Summer Paralympics, athletes with different disabilities were included for the first time at a Summer Paralympics. With the inclusion of more disability classifications the 1976 Summer Games expanded to 1,600 athletes from 40 countries. The 1988 Summer Paralympics in Seoul, South Korea, was another milestone for the Paralympic movement. It was in Seoul that the Paralympic Summer Games were held directly after the 1988 Summer Olympics, in the same host city, and using the same facilities. This set a precedent that was followed in 1992 Summer Paralympics, 1996 Summer Paralympics and 2000 Summer Paralympics. It was eventually formalized in an agreement between the International Paralympic Committee (IPC) and the International Olympic Committee (IOC) in 2001, and was extended through 2020. On March 10, 2018, the two committees further extended their contract to 2032. The 1992 Winter Paralympics were the first Winter Games to use the same facilities as the 1992 Winter Olympics. 
 Question: Which Summer Paralympics had more participating countries, the 1960 Summer Paralympics or the 1976 Summer Paralympics?
Output: 1976 summer paralympics
Context: According to Finnish historians, the casualties of the Finnish Defence Forces amounted to 63,204 dead or missing and around 158,000 wounded. Officially, the Soviets captured 2,377 Finnish prisoners of war in the Soviet Union, although Finnish researchers estimated the number to be around 3,500 prisoners. 939 Finnish civilians died in air raids and 190 civilians were killed by Soviet partisans. Germany suffered approximately 84,000 casualties in the Finnish front, 16,400 killed, 60,400 wounded and 6,800 missing. In addition to the original peace terms of restoring the 1940 border, Finland was required to Finnish war reparations to the Soviet Union, conduct War-responsibility trials in Finland, lease Porkkalanniemi to the Soviets as well as ban fascist elements and allow left-wing groups, such as the Communist Party of Finland. A Soviet-led Allied Control Commission was installed to enforce and monitor the peace agreement in Finland. The requirement to disarm or expel any German troops left on Finnish soil by 15 September 1944 eventually escalated into the Lapland War between Finland and Germany and the evacuation of the 200,000-strong 20th Mountain Army to Norway. 
 Question: Were more German casualties killed or missing?
Output: killed
Context: Nearly a quarter century after a German boy threw a message in a bottle off a ship in the Baltic Sea, he's received an answer. A 13yearold Russian, Daniil Korotkikh, was walking with his parents on a beach when he saw something lying in the sand. "I saw that bottle and it looked interesting, " Korotkikh told The Associated Press on Tuesday."It looked like a German beer bottle and there was a message inside." It said, "My name is Frank, and I'm five years old.My dad and I are travelling on a ship to Denmark.If you find this letter, please write back to me, and I will write back to you." The letter, dated 1987, included an address in the town of Coesfeld. The boy in the letter, Frank Uesbeck, is now 29.His parents still live at the letter's address. The Russian boy and the German man met each other earlier this month through an Internet video link.The Russian boy said he did not believe that the bottle actually spent 24 years in the sea.He believed it had been hidden under the sand where he found it for a long time. Uesbeck was especially happy that he was able to have a positive effect on a life of a young person far away from Germany."It's really a wonderful story, " he said."And who knows? Perhaps one day we will actually be able to arrange a meeting in person." 
 Question: What is this passage mainly about?
Output: message in a bottle.
Context: Earth and many other bodiesincluding asteroids, comets, and the other planetsmove around the sun in curved paths called orbits. Generally, the orbits are elliptical, or oval, in shape. You can see the shape of Earths orbit in the Figure 1.1. Because of the suns relatively strong gravity, Earth and the other bodies constantly fall toward the sun, but they stay far enough away from the sun because of their forward velocity to fall around the sun instead of into it. As a result, they keep orbiting the sun and never crash to its surface. The motion of Earth and the other bodies around the sun is called orbital motion. Orbital motion occurs whenever an object is moving forward and at the same time is pulled by gravity toward another object. Just as Earth orbits the sun, the moon also orbits Earth. The moon is affected by Earths gravity more than it is by the gravity of the sun because the moon is much closer to Earth. The gravity between Earth and the moon pulls the moon toward Earth. At the same time, the moon has forward velocity that partly counters the force of Earths gravity. So the moon orbits Earth instead of falling down to the surface of the planet. The Figure 1.2 shows the forces involved in the moons orbital motion around Earth. In the diagram, v represents the forward velocity of the moon, and a represents the acceleration due to gravity between Earth and the moon. The line encircling Earth shows the moons actual orbit, which results from the combination of v and a. 
 Question: the shape of the path in question 2 is
Output: elliptical.
Context: Normally the FLUID file defines one or more functions or classes, which output C++ code. 
 Question: Which programming language is FLUID written in?
Output: c++
Context: DNA must replicate (copy) itself so that each resulting cell after mitosis and cell division has the same DNA as the parent cell. All these cells, the parent cell and the two new daughter cells, are genetically identical. DNA replication occurs during the S phase (the Synthesis phase) of the cell cycle, before mitosis and cell division. The base pairing rules are crucial for the process of replication. DNA replication occurs when DNA is copied to form an identical molecule of DNA. The general steps involved in DNA replication are as follows: 1. The DNA helix unwinds like a zipper as the bonds between the base pairs are broken. The enzyme DNA Helicase is involved in breaking these bonds. 2. The two single strands of DNA then each serve as a template for a new stand to be created. Using DNA as a template means that on the new strand, the bases are placed in the correct order because of the base pairing rules. Recall that A and T are complementary bases, as are G and C. As a template strand is read, the new strand is created. If ATGCCA is on the "template strand," then TACGGT will be on the new DNA strand. The enzyme DNA Polymerase reads the template and builds the new strand of DNA. 3. The new set of nucleotides then join together to form a new strand of DNA. The process results in two DNA molecules, each with one old strand and one new strand of DNA. This process is known as semiconservative replication because one strand is conserved (kept the same) in each new DNA molecule ( Figure 1.1). DNA replication occurs when the DNA strands unzip, and the original strands of DNA serve as a template for new nucleotides to join and form a new strand. 
 Question: what is the first step in dna replication?
Output: the dna helix unwinds like a zipper.
Context: We describe the use of four complementary biosensors (Biacore 3000, Octet QK, ProteOn XPR36, and KinExA 3000) in characterizing the kinetics of human nerve growth factor (NGF) binding to a humanized NGF-neutralizing monoclonal antibody (tanezumab, formerly known as RN624). Tanezumab is a clinical candidate as a therapy for chronic pain. Our measurements were consistent with the NGF/tanezumab binding affinity being tighter than 10 pM due to the formation of an extremely stable complex that had an estimated half-life exceeding 100 h, which was beyond the resolution of any of our methods. The system was particularly challenging to study because NGF is an obligate homodimer, and we describe various assay orientations and immobilization methods that were used to minimize avidity in our experiments while keeping NGF in as native a state as possible. We also explored the interactions of NGF with its natural receptors, TrkA and P75, and how tanezumab blocks them. The Biacore blocking assay that we designed was used to quantify the potency of tanezumab and is more precise and reproducible than the currently available cell-based functional assays. 
 Question: What is the target of tanezumab?
Output: ngf
Context: We describe the use of four complementary biosensors (Biacore 3000, Octet QK, ProteOn XPR36, and KinExA 3000) in characterizing the kinetics of human nerve growth factor (NGF) binding to a humanized NGF-neutralizing monoclonal antibody (tanezumab, formerly known as RN624). Tanezumab is a clinical candidate as a therapy for chronic pain. Our measurements were consistent with the NGF/tanezumab binding affinity being tighter than 10 pM due to the formation of an extremely stable complex that had an estimated half-life exceeding 100 h, which was beyond the resolution of any of our methods. The system was particularly challenging to study because NGF is an obligate homodimer, and we describe various assay orientations and immobilization methods that were used to minimize avidity in our experiments while keeping NGF in as native a state as possible. We also explored the interactions of NGF with its natural receptors, TrkA and P75, and how tanezumab blocks them. The Biacore blocking assay that we designed was used to quantify the potency of tanezumab and is more precise and reproducible than the currently available cell-based functional assays. 
 Question: What is the target of tanezumab?
Output: nerve growth factor
Context: Water is simply two atoms of hydrogen and one atom of oxygen bonded together (Figure 1.1). The hydrogen ions are on one side of the oxygen ion, making water a polar molecule. This means that one side, the side with the hydrogen ions, has a slightly positive electrical charge. The other side, the side without the hydrogen ions, has a slightly negative charge. Despite its simplicity, water has remarkable properties. Water expands when it freezes, has high surface tension (because of the polar nature of the molecules, they tend to stick together), and others. Without water, life might not be able to exist on Earth and it certainly would not have the tremendous complexity and diversity that we see. Water is the only substance on Earth that is present in all three states of matter - as a solid, liquid or gas. (And Earth is the only planet where water is abundantly present in all three states.) Because of the ranges in temperature in specific locations around the planet, all three phases may be present in a single location or in a region. The three phases are solid (ice or snow), liquid (water), and gas (water vapor). See ice, water, and clouds (Figure 1.2). (a) Ice floating in the sea. Can you find all three phases of water in this image? (b) Liquid water. (c) Water vapor is invisible, but clouds that form when water vapor condenses are not. Click image to the left or use the URL below. URL: 
 Question: hydrogen atoms have this kind of charge.
Output: positive
Context: Extremaduran Popular Bloc (Spanish: Bloque Popular de Extremadura, BPEx) was a communist political coalition created in Extremadura in 1981 and dissolved in 1983. 
 Question: What year was the end of Extremaduran Popular Bloc?
Output: 1983
Context: Coming off their win over the Browns, the Bears stayed at home for a Week 9 duel with the Arizona Cardinals. Chicago would trail early in the first quarter as Cardinals quarterback Kurt Warner hooked up with wide receiver Larry Fitzgerald on an 11-yard touchdown pass. The Bears would answer as quarterback Jay Cutler competed a 33-yard touchdown pass to tight end Greg Olsen, but Arizona came right back as Warner hooked up with tight end Ben Patrick on a 6-yard touchdown pass. Chicago would find themselves in a huge deficit in the second quarter as Warner completed a 17-yard touchdown pass to Fitzpatrick and a 15-yard touchdown pass to tight end Anthony Becht, followed by kicker Neil Rackers nailing a 43-yard field goal. The Cardinals would add onto their lead as Rackers booted a 30-yard field goal in the third quarter. The Bears tried to rally in the fourth quarter as Cutler connected with Olsen on a 3-yard and a 20-yard touchdown pass, but Arizona pulled away with Warner completing a 4-yard touchdown pass to wide receiver Steve Breaston. 
 Question: Which playe scored three touchdowns?
Output: greg olsen
Context: Even while in a deep sleep, people can still learn brand new information. Sleepers soak in new associations between smells and sounds, knowledge that lingers into the next waking day, researchers report online August 26 in Nature Neuroscience. The new study is the first to show that entirely new information can get into the sleeping mind, says Anat Arzi of the Weizmann Institute of Science in Israel. "The brain is not passive while you sleep. It's quite active. You can do quite a lot of things while you are asleep." But the results don't mean that Spanish vocabulary tapes now have a place on the nightstand. L, Researchers have tried but largely failed to find evidence that complicated information, such as new pairs of words, can make its way into the brain during sleep. Instead of trying to teach people something complicated like a new language, Arzi and her colleagues relied on the sense of smell and hearing. As anyone who has walked by a dumpster in July knows, smells can cause a nose-jerk reaction. Catching a bad smell automatically makes people inhale less, reducing the size of the inhale. But scent of fresh bread causes a long, deep inhale., rzi and her team took advantage of this reaction for their experiment. As people slept in the laboratory, the researchers delivered pleasant scent, such as shampoo. As this nice smell got into the sleepers' noses, the researchers played a particular music. Later, a disgusting smell, such as rotten fish or meat, was paired with a different music. Neither the smell nor the sound woke people up. After just four exposures to the smell-music pair during a single night, the sleepers started to automatically respond to the tones without the accompanying smells, taking in bigger breaths when the shampoo-associated tone played and smaller breaths when played the sound linked to the rotten fish smell. This new learned association lingered into the next waking day, too. Even though the sleepers had no idea they had been exposed to smells or sounds, their behavior proved that their brain had actually learned something during sleep. As before, the shampoo sound stimulated a long, deep inhale, while the rotten fish tone caused more shallow breaths. 
 Question: In which part of a website may this passage most likely appear?
Output: science.
Context: Dipterocarpus grandiflorus is a critically endangered common medium hardwood tree in South-East Asia and India. 
 Question: What is the iucn conservation status of Dipterocarpus grandiflorus?
Output: critically endangered
Context: Bertuccio Valiero was the son of Silvestro Valiero and Bianca Priuli. 
 Question: What was Bertuccio Valiero's child's name?
Output: silvestro valiero
Context: Co-occurring psychiatric diagnoses have a negative impact on quality of life and change the presentation and prognosis of bipolar disorder (BD). To date, comorbidity research on patients with BD has primarily focused on co-occurring anxiety disorders and trauma history; only recently has there been a specific focus on co-occurring PTSD and BD. Although rates of trauma and PTSD are higher in those with bipolar disorder than in the general population, little is known about differences across bipolar subtypes. Using the NIMH STEP-BD dataset (N=3158), this study evaluated whether there were baseline differences in the prevalence of PTSD between participants with bipolar disorder I (BDI) and bipolar disorder II (BDII), using the MINI and the Davidson Trauma Scale. Differences in PTSD symptom clusters between patients with BDI and BDII were also evaluated. A significantly greater proportion of participants with BDI had co-occurring PTSD at time of study entry ((2)(1)=12.6; p<.001). BDI and BDII subgroups did not significantly differ in re-experiencing, avoidance, or arousal symptoms. The analysis may suggest a correlational relationship between PTSD and BD, not a causal one. Further, it is possible this population seeks treatment more often than individuals with PTSD alone. Finally, due to the episodic nature of BD and symptom overlap between the two disorders, misdiagnosis is possible. PTSD may be more prevalent in patients with BDI. However, the symptom presentation of PTSD appears similar across BD subtypes. Individuals should be thoroughly assessed for co-occurring diagnoses in an effort to provide appropriate treatment. 
 Question: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
Output: ptsd
Context: Co-occurring psychiatric diagnoses have a negative impact on quality of life and change the presentation and prognosis of bipolar disorder (BD). To date, comorbidity research on patients with BD has primarily focused on co-occurring anxiety disorders and trauma history; only recently has there been a specific focus on co-occurring PTSD and BD. Although rates of trauma and PTSD are higher in those with bipolar disorder than in the general population, little is known about differences across bipolar subtypes. Using the NIMH STEP-BD dataset (N=3158), this study evaluated whether there were baseline differences in the prevalence of PTSD between participants with bipolar disorder I (BDI) and bipolar disorder II (BDII), using the MINI and the Davidson Trauma Scale. Differences in PTSD symptom clusters between patients with BDI and BDII were also evaluated. A significantly greater proportion of participants with BDI had co-occurring PTSD at time of study entry ((2)(1)=12.6; p<.001). BDI and BDII subgroups did not significantly differ in re-experiencing, avoidance, or arousal symptoms. The analysis may suggest a correlational relationship between PTSD and BD, not a causal one. Further, it is possible this population seeks treatment more often than individuals with PTSD alone. Finally, due to the episodic nature of BD and symptom overlap between the two disorders, misdiagnosis is possible. PTSD may be more prevalent in patients with BDI. However, the symptom presentation of PTSD appears similar across BD subtypes. Individuals should be thoroughly assessed for co-occurring diagnoses in an effort to provide appropriate treatment. 
 Question: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
Output: post-traumatic stress disorder
Context: As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language. 
 Question: Which ancestral group is larger: English or Italian?
Output: english
Context: Wong Wo Bik () is a fine arts photographer and one of the few active female photographers in Hong Kong. 
 Question: What gender is Wong Wo Bik of?
Output: female
Context: 14 Herculis or 14 Her is the Flamsteed designation of a K-type main-sequence star approximately 57 light-years away in the constellation Hercules. 
 Question: What constellation is where 14 Herculis is?
Output: hercules
Context: In the county, the population was spread out with 23.20% under the age of 18, 7.70% from 18 to 24, 27.00% from 25 to 44, 28.00% from 45 to 64, and 14.10% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 97.00 males. For every 100 females age 18 and over, there were 96.40 males. 
 Question: Which age group is smaller: under the age of 18 or 18 to 24?
Output: 18 to 24
Context: Haribo (/hrbo/ HARR-i-boh) is a German confectionery company, founded in 1920 by Johannes ''Hans'' Riegel, Sr. It is headquartered in Bonn and the name comes from an abbreviation of Hans Riegel, Bonn. 
 Question: In what city is Haribo locateed?
Output: bonn
Context: Ultrasound is sound that has a wave frequency higher than the human ear can detect. It includes all sound with wave frequencies higher than 20,000 waves per second, or 20,000 hertz (Hz). Although we cant hear ultrasound, it is very useful to humans and some other animals. Uses of ultrasound include echolocation, sonar, and ultrasonography. Animals such as bats and dolphins send out ultrasound waves and use their echoes, or reflected waves, to identify the locations of objects they cannot see. This is called echolocation. Animals use echolocation to find prey and avoid running into objects in the dark. You can see in the Figure 1.1 how a bat uses echolocation to find insect prey. Sonar uses ultrasound in a way that is similar to echolocation. Sonar stands for sound navigation and ranging. It is used to locate underwater objects such as submarines. Thats how the ship pictured in the Figure 1.2 is using it. A sonar device is both a sender and a receiver. It sends out ultrasound waves and detects the waves after they reflect from underwater objects. The distance to underwater objects can be calculated from the known speed of sound in water and the time it takes for the sound waves to travel to the object. The equation for distance traveled when speed and time are known is: Distance = Speed Time Consider the ship and submarine pictured in the Figure 1.2. If an ultrasound wave travels from the ship to the submarine and back again in 2 seconds, what is the distance from the ship to the submarine? The sound wave travels from the ship to the submarine in just 1 second, or half the time it takes to make the round trip. The speed of sound waves through ocean water is 1437 m/s. Therefore, the distance from the ship to the submarine is: Q: Now assume that the sonar device on the ship sends an ultrasound wave to the bottom of the water. If the sound wave is reflected back to the device in 4 seconds, how deep is the water? A: The time it takes the wave to reach the bottom is 2 seconds. So the distance from the ship to the bottom of the water is: Distance = 1437 m/s 2 s = 2874 m Another use of ultrasound is to see inside the human body. This use of ultrasound is called ultrasonography. Harmless ultrasound waves are sent inside the body, and the reflected waves are used to create an image on a screen. This technology is used to examine internal organs and unborn babies without risk to the patient. You can see a doctor using ultrasound in the Figure 1.3. 
 Question: the speed of sound waves through ocean water is 1437 m/s. assume that ultrasound waves take 2 seconds to travel from a sonar device on a ship to the bottom of the water and back to the ship again. how deep is the water?
Output: 1437 m