niryuu/sni-each-converted huggingface dataset:
Context: Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by a specific deficiency in erythroid progenitors. Since some patients with DBA develop a reduction in thrombocytes and granulocytes with age, we asked whether multipotent hematopoietic progenitors from DBA patients had normal proliferative capacity in liquid expansion cultures. CD34(+) cells derived from DBA patients showed deficient proliferation in liquid culture containing IL-3, IL-6, and SCF. Single CD34(+) CD38(-) cells from DBA patients exhibited deficient proliferation recruitment in a limiting dilution assay containing IL-3, IL-6, SCF, Tpo, FL, and G-CSF or containing IL-3, IL-6, and SCF. Our findings suggest that the underlying hematopoietic defect in DBA may not be limited to the erythroid lineage. Since a fraction of DBA patients have a deficiency in ribosomal protein S19 (RPS19), we constructed lentiviral vectors containing the RPS19 gene for overexpression in hematopoietic progenitors from RPS19-deficient DBA patients. Enforced expression of the RPS19 transgene improved the proliferation of CD34(+) cells from DBA patients with RPS19 mutation. Similarly, enforced expression of RPS19 improved erythroid development of RPS19-deficient hematopoietic progenitors as determined by colony assays and erythroid differentiation cultures. These findings suggest that gene therapy for RPS19-deficient DBA is feasible. 
 Question: In which syndrome is the RPS19 gene most frequently mutated?
Output: dba
Context: Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by a specific deficiency in erythroid progenitors. Since some patients with DBA develop a reduction in thrombocytes and granulocytes with age, we asked whether multipotent hematopoietic progenitors from DBA patients had normal proliferative capacity in liquid expansion cultures. CD34(+) cells derived from DBA patients showed deficient proliferation in liquid culture containing IL-3, IL-6, and SCF. Single CD34(+) CD38(-) cells from DBA patients exhibited deficient proliferation recruitment in a limiting dilution assay containing IL-3, IL-6, SCF, Tpo, FL, and G-CSF or containing IL-3, IL-6, and SCF. Our findings suggest that the underlying hematopoietic defect in DBA may not be limited to the erythroid lineage. Since a fraction of DBA patients have a deficiency in ribosomal protein S19 (RPS19), we constructed lentiviral vectors containing the RPS19 gene for overexpression in hematopoietic progenitors from RPS19-deficient DBA patients. Enforced expression of the RPS19 transgene improved the proliferation of CD34(+) cells from DBA patients with RPS19 mutation. Similarly, enforced expression of RPS19 improved erythroid development of RPS19-deficient hematopoietic progenitors as determined by colony assays and erythroid differentiation cultures. These findings suggest that gene therapy for RPS19-deficient DBA is feasible. 
 Question: In which syndrome is the RPS19 gene most frequently mutated?
Output: diamond-blackfan anemia
Context: After a tough loss at home to the Lions, the Eagles traveled down south to New Orleans to take on the Saints in the Mercedes-Benz Superdome. The Saints scored first with Patrick Robinson returning a Michael Vick interception 99 yards for a touchdown and a 7-0 lead for the only score of the game. The Eagles got on the board in the 2nd quarter as Alex Henery kicked a 22-yard field goal to cut the lead to 7-3 not long before Chris Ivory ran for a 22-yard touchdown to move the Saints ahead by 11 with a 14-3 lead and then they would score again with Drew Brees finding Marques Coltson on a 1-yard touchdown pass for a 21-3 halftime lead. The Eagles scored 10 unanswered points in the 3rd quarter with Vick hooking up with DeSean Jackson on a 77-yard touchdown pass for a score of 21-10 and then Henery kicked a 37-yard field goal for a score of 21-13. But the Saints scored one last time as Brees found Jimmy Graham on a 6-yard touchdown pass for a 28-13 lead which would be the final score of the game as neither team scored in the 4th quarter. 
 Question: Which quarterback threw the most touchdown passes?
Output: drew brees
Context: Bazex syndrome, or acrokeratosis paraneoplastica, is a cutaneous paraneoplastic syndrome characterized by psoriasiform lesions associated with, usually, a squamous cell carcinoma of the upper aerodigestive tract. We present a case of Bazex syndrome associated with metastatic cervical squamous cell carcinoma with an unknown primary. The features of the condition are discussed in the light of current knowledge. 
 Question: Name synonym of Acrokeratosis paraneoplastica.
Output: bazex syndrome
Context: Borderline oxacillin-resistant Staphylococcus aureus (BORSA) may be misidentified as intrinsically methicillin-resistant Staphylococcus aureus (MRSA) in the clinical laboratory. Under disk diffusion testing conditions designed to maximize detection of MRSA (incubation at 32 degrees C, pre-induction with methicillin, or plating on 4% NaCl-supplemented agar), BORSA strains also tend to appear resistant to semisynthetic penicillins. Under these conditions, ampicillin/sulbactam appears to be more accurate than amoxicillin/clavulanic acid for differentiating BORSA from MRSA. 
 Question: What is BORSA?
Output: borderline oxacillin-resistant staphylococcus aureus
Context: Spleen tyrosine kinase (SYK) is the best known for its involvement in immune receptor signalling, mediated by binding of SYK tandem Src-homology 2 domains to tandem phosphotyrosine in immunoreceptor tyrosine-based activation motifs (ITAMs). ITAM adaptors or ITAM-containing receptor tails mediate signalling from B- and T-cell receptors, Fc receptors and many C-type lectins, including dectin-1. Recent data point to constitutive binding of SYK to the cytoplasmic domain of toll-like receptor-4 (TLR4). This SYK-TLR4 binding increases upon TLR4 dimerization and phosphorylation, and SYK plays a prominent role in TLR4 signalling in response to LPS in neutrophils and monocytes. SYK also plays an important role in TLR4-mediated macrophage responses to minimally oxidized low-density lipoprotein (mmLDL), which is a form of oxidized LDL relevant to development of human atherosclerosis. Interestingly, mmLDL-induced effects in macrophages, which occur via TLR4, are predominantly MyD88 independent. This unmasks the role of the SYK branch of TLR4 signalling, which mediates modest cytokine release via activation of AP-1 transcription and robust reactive oxygen species generation and cytoskeletal rearrangements. The latter results in extensive membrane ruffling and macropinocytosis, leading to lipoprotein uptake and foam cell formation, a hallmark of atherosclerotic lesions. Because inhibitors of SYK activity, such as fostamatinib, are in advanced clinical trials for rheumatoid arthritis and other autoimmune diseases, understanding the role of SYK in signalling via TLR4 is of immediate importance. This signalling pathway seems to be particularly important in TLR4 activation by host-derived, damage-associated molecular pattern ligands, such as mmLDL, relevant to development of atherosclerosis and other chronic inflammatory diseases. 
 Question: Which enzyme is inhibited by a drug fostamatinib?
Output: spleen tyrosine kinase
Context: Australian Senator Nick Xenophon said, ''Tom Waterhouse has pushed the envelope to the extent that it has now got to the point that it's out of control and there needs to be a legislative response'' In May 2013, Waterhouse was directed by NSW Racing stewards to keep his bookmaking business clearly separate from the training business of his mother Gai Waterhouse, to avoid public perceptions of a conflict of interest. 
 Question: Who is the mother of Tom Waterhouse?
Output: gai waterhouse
Context: The acromelic dysplasia group includes three rare disorders: Weill-Marchesani syndrome (WMS), Geleophysic dysplasia (GD) and Acromicric dysplasia (AD) all characterized by short stature, short hands and stiff joints. The clinical overlap between the three disorders is striking. Indeed, in addition to the diagnostic criteria, they all share common features including delayed bone age, cone shaped epiphyses, thick skin and heart disease. In contrast, a microspherophakic lens seems to be a characteristic feature of WMS whereas hepatomegaly and a severe outcome are encountered only in the most severe forms of GD. Finally, WMS is transmitted either by an autosomal dominant or an autosomal recessive (AR) mode of inheritance, GD by an autosomal recessive mode of inheritance and AD by an autosomal dominant mode of inheritance. Using genetic approaches, we have identified the molecular basis of WMS and GD which both involved the same superfamily of proteins, the ADAMTS [A Disintegrin-like And Metalloproteinase domain (reprolysin type) with ThromboSpondin type 1 repeats (TSR)]. We have found ADAMTS10 mutations in the recessive form of WMS and Fibrillin 1 mutations in the dominant form of WMS. More recently, we have identified ADAMTSL2 mutations in GD. The function of ADAMTS1 0 and AD AMTSL 2 are unknown. But the findings of FBN1 and ADAMTS10 mutations in WMS suggest a direct link between the two proteins. Using a yeast double hybrid screen, we have identified LTBP1 (Latent TGFbeta Binding protein 1) as a partner of ADAMTSL2. The combination of these findings suggests that ADAMTS10 and ADAMTSL2 are both involved in the microfibrillar network. 
 Question: What is the mode of inheritance of Marchesani syndrome?
Output: autosomal dominant or autosomal recessive
Context: Pwytter is a standalone Twitter GUI client written in Python with tkInter. 
 Question: What is the programming language for Pwytter?
Output: python
Context: A magnet is an object that attracts certain materials such as iron. Youre probably familiar with common bar magnets, like the one shown in the Figure 1.1. Like all magnets, this bar magnet has north and south magnetic poles. The red end of the magnet is the north pole and the blue end is the south pole. The poles are regions where the magnet is strongest. The poles are called north and south because they always line up with Earths north-south axis if the magnet is allowed to move freely. (Earths axis is the imaginary line around which the planet rotates.) Q: What do you suppose would happen if you cut the bar magnet pictured in the Figure 1.1 along the line between the north and south poles? A: Both halves of the magnet would also have north and south poles. If you cut each of the halves in half, all those pieces would have north and south poles as well. Pieces of a magnet always have both north and south poles no matter how many times you cut the magnet. The force that a magnet exerts on certain materials, including other magnets, is called magnetic force. The force is exerted over a distance and includes forces of attraction and repulsion. North and south poles of two magnets attract each other, while two north poles or two south poles repel each other. A magnet can exert force over a distance because the magnet is surrounded by a magnetic field. In the Figure 1.2, you can see the magnetic field surrounding a bar magnet. Tiny bits of iron, called iron filings, were placed under a sheet of glass. When the magnet was placed on the glass, it attracted the iron filings. The pattern of the iron filings shows the lines of force that make up the magnetic field of the magnet. The concentration of iron filings near the poles indicates that these areas exert the strongest force. You can also see how the magnetic field affects the compasses placed above the magnet. When two magnets are brought close together, their magnetic fields interact. You can see how they interact in the Figure 1.3. The lines of force of north and south poles attract each other whereas those of two north poles repel each other. 
 Question: a magnets force is
Output: exerted over a distance.
Context: In contrast to the teams' previous meeting, the grand opening of Cowboys Stadium (in front of the largest regular-season crowd in NFL history) was a fast-paced shootout. The first points in the Cowboys' new home were scored by Tynes, whose 30-yard field goal in the first quarter was his first of four on the night. The Cowboys responded by scoring their first points on the ensuing drivea 2-yard run by running back Marion Barber. Giants rookie cornerback Bruce Johnson scored his first career points returning a Tony Romo interception 34 yards. Cowboys tight end Jason Witten responded with a 1-yard touchdown pass in the second quarter. Later, Giants safety Kenny Phillips caught an odd interception off Witten's foot, setting up quarterback Eli Manning's 100th career touchdown passa 22-yard strike to Manningham. Romo ran a quarterback sneak to open the scoring in the second half, but the Giants sent wide receiver Steve Smith into the end zone in the fourth quarter. The Cowboys punched in one more touchdown on a 7-yard Felix Jones run, but Tynes' 37-yard field goal as time expired was enough to postpone the Cowboys' first home win in Arlington and boost the Giants to 2-0. The Giants lost two more notable players to injuries; defensive end Justin Tuck suffered a sprained shoulder and wide receiver Domenik Hixon sprained a knee. During the week, Phillips' season was brought to an end, as he was placed on injured reserve with patellofemoral arthritis. 
 Question: Which team scored more field goals?
Output: cowboys
Context: The Get Up Kids are an American rock band from Kansas City, Missouri. 
 Question: What city was The Get Up Kids formed in?
Output: kansas city
Context: If the Cap Fits... is the sixth episode of the fifth series of the British television sitcom Dad's Army that was originally transmitted on 10 November 1972. 
 Question: Which show does If the Cap Fits... appear on?
Output: dad's army
Context: Chediak Higashi syndrome (CHS) is an autosomal-recessive disorder characterized by oculocutaneous albinism, recurrent infections and a progressive primary neurological disease. Here, we describe two siblings with CHS due to a novel homozygous R1836X mutation in the LYST gene associated with loss of NK cell degranulation and cytotoxicity. While one sibling was born with fair skin and hair and died of hemophagocytic lymphohistiocytosis (HLH) at 5 months of age, the other sibling had dark black hair and skin and developed HLH at the age of 4 years. 
 Question: Which syndrome is associated with mutations in the LYST gene?
Output: chediak higashi syndrome
Context: Chediak Higashi syndrome (CHS) is an autosomal-recessive disorder characterized by oculocutaneous albinism, recurrent infections and a progressive primary neurological disease. Here, we describe two siblings with CHS due to a novel homozygous R1836X mutation in the LYST gene associated with loss of NK cell degranulation and cytotoxicity. While one sibling was born with fair skin and hair and died of hemophagocytic lymphohistiocytosis (HLH) at 5 months of age, the other sibling had dark black hair and skin and developed HLH at the age of 4 years. 
 Question: Which syndrome is associated with mutations in the LYST gene?
Output: chediak-higashi syndrome
Context: The Rebellion was the career highlight for both leaders; Cumberland resigned from the Army in 1757 and died of a stroke in 1765. Charles was initially treated as a hero on his return to Paris but the Stuarts were once again barred from France by the 1748 Treaty of Aix-la-Chapelle. Henry Stuart's entry into the Catholic Church in June 1747 was seen as tacit acceptance the Jacobites were finished and Charles never forgave him. He continued attempts to reignite the cause, including a secret visit to London in 1750 but habitual heavy drinking made him argumentative and hard to work with. In 1759, he met French Chief Minister de Choiseul to discuss another invasion attempt but Choiseul dismissed him as incapable through drink. When his father James died in 1766, Pope Clement XIII refused to recognise him as Charles III, despite the strong objections of his brother Henry. Charles never visited Britain again and died in Rome in January 1788, a disappointed and embittered man. 
 Question: Who tried to get Pope Clement XIII to recognize Charles III?
Output: his brother henry
Context: In the county, the population was spread out with 23.5% under the age of 18, 7.8% from 18 to 24, 28.5% from 25 to 44, 25.9% from 45 to 64, and 14.2% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 93.8 males. For every 100 females age 18 and over, there were 90.5 males. 
 Question: How old was the majority of the population?
Output: 25 to 44
Context: Organisms are individual living things. They range from microscopic bacteria to gigantic blue whales (see Figure must be obtained from the environment. Biotic factors are all of the living or once-living aspects of the environment. They include all the organisms that live there as well as the remains of dead organisms. Abiotic factors are all of the aspects of the environment that have never been alive. They include factors such as sunlight, minerals in soil, temperature, and moisture. Ecologists study organisms and environments at several different levels, from the individual to the biosphere. The levels are depicted in Figure 23.2 and described below. For a video introduction to the levels of organization in ecology, click on this link: . MEDIA Click image to the left or use the URL below. URL: An individual is an organism, or single living thing. A population is a group of individuals of the same species that live in the same area. Members of the same population generally interact with each other. A community is made up of all the populations of all the species that live in the same area. Populations in a community also generally interact with each other. 
 Question: Ecosystems in a biome have the same general
Output: abiotic factors.
Context: Interleukin-1 (IL-1) is a key orchestrator in inflammatory and several immune responses. IL-1 exerts its effects through interleukin-1 receptor type I (IL-1RI) and interleukin-1 receptor accessory protein (IL-1RAcP), which together form a heterotrimeric signaling-competent complex. Canakinumab and gevokizumab are highly specific IL-1 monoclonal antibodies. Canakinumab is known to neutralize IL-1 by competing for binding to IL-1R and therefore blocking signaling by the antigen:antibody complex. Gevokizumab is claimed to be a regulatory therapeutic antibody that modulates IL-1 bioactivity by reducing the affinity for its IL-1RI:IL-1RAcP signaling complex. How IL-1 signaling is affected by both canakinumab and gevokizumab was not yet experimentally determined. We have analyzed the crystal structures of canakinumab and gevokizumab antibody binding fragment (Fab) as well as of their binary complexes with IL-1. Furthermore, we characterized the epitopes on IL-1 employed by the antibodies by NMR epitope mapping studies. The direct comparison of NMR and X-ray data shows that the epitope defined by the crystal structure encompasses predominantly those residues whose NMR resonances are severely perturbed upon complex formation. The antigen:Fab co-structures confirm the previously identified key contact residues on IL-1 and provide insight into the mechanisms leading to their distinct modulation of IL-1 signaling. A significant steric overlap of the binding interfaces of IL-1R and canakinumab on IL-1 causes competitive inhibition of the association of IL-1 and its receptor. In contrast, gevokizumab occupies an allosteric site on IL-1 and complex formation results in a minor reduction of binding affinity to IL-1RI. This suggests two different mechanisms of IL-1 pathway attenuation. 
 Question: Which molecule is targeted by the drug Gevokizumab?
Output: il-1β
Context: In 1908 the U.S. Supreme Court decided Loewe v. Lawlor . In 1902 the Hatters' Union instituted a nationwide boycott of the hats made by a nonunion company in Connecticut. Owner Dietrich Loewe brought suit against the union for unlawful combinations to restrain trade in violation of the Sherman Antitrust Act. The Court ruled that the union was subject to an injunction and liable for the payment of triple damages. In 1915 Justice Oliver Wendell Holmes, speaking for the Court, again decided in favor of Loewe, upholding a lower federal court ruling ordering the union to pay damages of $252,130. . This was not a typical case in which a few union leaders were punished with short terms in jail; specifically, the life savings of several hundreds of the members were attached. The lower court ruling established a major precedent, and became a serious issue for the unions. The Clayton Act of 1914 presumably exempted unions from the antitrust prohibition and established for the first time the Congressional principle that "the labor of a human being is not a commodity or article of commerce". However, judicial interpretation so weakened it that prosecutions of labor under the antitrust acts continued until the enactment of the Norris-La Guardia Act in 1932. 
 Question: Who did Loewe sue?
Output: hatters' union
Context: The current President of Krakow, re-elected for his fourth term in 2014, is Jacek Majchrowski. 
 Question: Who was in charge of Krakow?
Output: jacek majchrowski
Context: World Book Day is a celebration of all things wonderful about books for all ages, with author events, school fancy-dress parades and a PS1 book token given to all school children under 18. It is a yearly event on 23rd April, organized by the United Nations Educational, Scientific and Cultural Organization ( UNESCO ) to promote reading. In the United Kingdom, the day is recognized on the first Thursday in March. On 3rd March 2016 children of all ages in the UK will come together to appreciate reading. Sometimes, reading a modern novel can be tough ( Booker Prize winner The Luminaries runs to 832 pages! ), especially if reading is not your strong suit. In fact, one in six people in the UK never pick up a book because they've experienced difficulties or are out of the habit of reading for pleasure. The Galaxy Quick Reads series are designed to introduce reluctant readers to bestselling short funny novels, which bring the joy of reading without demanding hours of concentrated time. They cover a range of subjects, from romance to comedy. Jojo Moyes's Paris For One is a romantic adventure in which 26-year-old Nell books a weekend away to Paris with her lazy, neglectful boyfriend. When he fails to turn up, she is alone in the city. That is, until she meets Fabien, who shows her the charms of the French capital -- in more ways than one. Adele Geras's moving story Out In The Dark was set in World War I, in which young Rob came back from the battlefields. Determined to find the officer's widow to return the photo of her and their daughter that the captain kept with him, he traveled several thousand miles but never gave up. Dead Man Talking is a fantastic tale of Pat, who had a terrible fight with his best friend, Joe, ten years ago -- but now hears that Joe is dead, and he must attend his funeral. But Joe is not going quietly that very night -- he's lying in his coffin being very chatty indeed. 
 Question: What else do you expect the author to introduce?
Output: a comedy.
Context: The launch occurred on 12 June 1970 at 09:30:02 UTC, and resulted in the successful deployment of Kosmos 347 into low Earth orbit. 
 Question: What date was Kosmos 347 launched?
Output: 12 june 1970
Context: If you are a high school senior graduating and looking to enter college in 2006, you will take the new exam. The biggest change to the SAT will be the introduction of a new writing section. The writing section will consist of two parts: an essay and a multiple-choice section. Students will be given 25 minutes to respond to a prompt and construct a well-organized essay that effectively deals with the task. The essay question may require students to complete a statement, to react to a quote, or to agree or disagree with a point of view. In any case, a good essay will support the chosen position with specific reasons and examples from literature, history, art, science, current affairs, or even a student's own experiences. Essays will be scored based on the procedures for the current SAT II: Writing Test. Essays will be graded by two independent readers On a scale of 1~6, and their two scores will be combined to form an essay subscore that ranges from 2 to 12. Should the readers' scores vary by more than 2 points, a third reader will score the essay; The readers will be high school teachers and college professors who teach composition. To ensure that essays will be scored in a timely manner, they will be scanned and made available to readers on the Internet for grading purpose. The writing section will also include multiple-choice grammar and usage questions. Some of these questions will call upon students to improve given sentences and paragraphs. Others will present students with sentences and require them to identify mistakes in diction , grammar, sentence construction, subject-verb agreement, proper word usage. The highest possible score on the new writing section will be 800. Scores on the essay and multiple-choice section will be combined to produce a single score. A writing subscore will also be assigned. The highest possible scores on the Critical Reading and Math sections will remain 800 each, making 2,400 a perfect score on the new SAT. 
 Question: Which parts are included in the writing section of SAT according to the passage?
Output: essay and multiple-choice.
Context: The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Three distinct stages in the mechanism can be recognized. Initially, fragments of invader DNA are integrated as new spacers into the repetitive CRISPR locus. Subsequently, the CRISPR is transcribed and the transcript is cleaved by a Cas protein within the repeats, generating short RNAs (crRNAs) that contain the spacer sequence. Finally, crRNAs guide the Cas protein machinery to a complementary invader target, either DNA or RNA, resulting in inhibition of virus or plasmid proliferation. In this article, we discuss our current understanding of this fascinating adaptive and heritable defense system, and describe functional similarities and differences with RNAi in eukaryotes. 
 Question: Gene silencing can be achieved by RNA interference (RNAi) in eukaryotic organisms. What is the name of the analogous process in prokaryotic organisms?
Output: crispr-cas
Context: Lev Abalkin (2138 - 2178) is a fictional character in Boris and Arkady Strugatsky's series of science fiction novels set in the Noon Universe. 
 Question: What is the fictional universe that Lev Abalkin appears in?
Output: noon universe
Context: Playing again without Calvin Johnson, the Lions fell behind the visiting New Orleans Saints by two scores on two separate occasions, before mounting a dramatic comeback in the final minutes of the game. New Orleans had three of the first four scoring plays of the game. Drew Brees hit Austin Johnson with a 14-yard TD pass, Shayne Graham made good on a 27-yard field goal, and Kenny Stills caught a 46-yard TD pass from Brees. Meanwhile, the Lions could only muster a 21-yard field goal by Matt Prater, falling behind 17-3. Detroit closed the gap to 17-10 in the third quarter after a 1-yard TD run by Joique Bell. Two more Shayne Graham field goals, however, gave the Saints a seemingly comfortable 23-10 lead with 5:24 to play in the game. With under four minutes to play, Matthew Stafford connected with Golden Tate on a 73-yard catch-and-run, making the score 23-17. On the Saints' next possession, Glover Quin picked off a third-and-ten Drew Brees pass, returning it to the New Orleans 14-yard line. At the 1:48 mark, Corey Fuller made a leaping catch of a 5-yard TD pass from Stafford for the winning touchdown in a 24-23 game. The Lions' defense held off the Saints in four downs, then the offense ran out the clock for the win. 
 Question: Who is the Saints' kicker?
Output: shayne graham
Context: Helen Cunningham (previously Richardson) is a fictional character from the long-running Channel 4 soap opera, Hollyoaks, played by Kathryn George. 
 Question: In what fictional work would you find a character named Helen Cunningham?
Output: hollyoaks
Context: The Nicobar parakeet is classified as near-threatened by the IUCN. 
 Question: What is the endangered status of Nicobar parakeet?
Output: near-threatened
Context: Siltuximab, a chimeric monoclonal antibody with high affinity and specificity for interleukin-6, has been shown to enhance anti-multiple myeloma activity of bortezomib and corticosteroid in vitro. We evaluated the safety, pharmacokinetics, immunogenicity, and antitumor effect of siltuximab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory multiple myeloma. This open-label, phase 1, dose-escalating study used two doses of siltuximab: 5.5 and 11.0 mg/kg (administered on day 1 of each 21-day cycle). In total, nine patients were treated. The most common grade 3/4 adverse events, lymphopenia (89 %) and thrombocytopenia (44 %), occurred in patients receiving both doses of siltuximab; however, no dose-limiting toxicities (DLTs) were observed. Following intravenous administration of siltuximab at 5.5 and 11.0 mg/kg, the maximum serum concentration and the area under the curve from 0 to 21 days and from 0 to infinity increased in an approximately dose-proportional manner. Mean half-life, total systemic clearance, and volume of distribution were similar at doses of 5.5 and 11.0 mg/kg. Across both doses, six of the nine patients had complete or partial response (22 and 44 %, respectively). In conclusion, as no DLT was observed, the recommended dose for this combination is 11.0 mg/kg once every 3 weeks. The study is registered at [Link] as NCT01309412. 
 Question: Which interleukin is blocked by Siltuximab?
Output: interleukin-6
Context: He was the son of The 4th Earl of Clanricarde by his wife Frances Walsingham. Ulick's father was from an Anglo-Norman family who had been long settled in the west of Ireland and had become Gaelicised. Although during the early sixteenth century the family had rebelled against the Crown on several occasions, Ulick's father had been a strong supporter of Queen Elizabeth I. He fought on the Queen's side during Tyrone's Rebellion, notably during the victory at the Battle of Kinsale, where he was wounded. After the war he married the widow of The 2nd Earl of Essex, a recent commander in Ireland, who was the daughter of the English Secretary of State and spymaster Sir Francis Walsingham. In 1622, Ulick married his only wife Anne Compton, the daughter of The 1st Earl of Northampton and his wife, Elizabeth Spencer. They had a single child, Margaret Burgh, who married Viscount Muskerry. Ulick was summoned to the House of Lords as Lord Burgh in 1628, and succeeded his father as 5th Earl of Clanricarde in 1635. In 1636, he inherited Somerhill House on the death of his father. He was a staunch opponent of the policies of the Lord Deputy of Ireland, The 1st Earl of Strafford, who had attempted to seize much of the great Burke inheritance for the Crown; there was also personal ill-feeling between the two men since the dispute was thought by many to have hastened the death of Ulick's elderly father. He sat in the Short Parliament of 1640 and attended King Charles I in the Scottish expedition. Charles, unlike Strafford, liked and trusted Lord Clanricarde. 
 Question: Who did not trust Lord Clanricarde?
Output: strafford
Context: The Conquest of Melilla occurred in September 1497, when a fleet sent by the Duke of Medina Sidonia seized the north African city of Melilla., as continuation of Reconquest of Mauritania Tingitana During the 15th century the mediterranean cities of the Sultanate of Fez fell in decadence in opposition to cities located in the Atlantic facade, which concentrated most of the economic activity. By the end of the 15th century, the port of Melilla, that had been often disputed between the rulers of Fez and Tlemcen, was nearly abandoned. Plans for the conquest occurred as soon as the Fall of Granada in 1492. Spanish captains Lezcano and Lorenzo Zafra visited the coast of Northern Africa to identify possible locations for the Spanish to overtake, and Melilla was identified as a prime candidate. Melilla was, however, in the Portuguese zone of influence under the terms of the 1479 Treaty of Alcacovaz. At Tordesillas in 1494, King John II of Portugal, the Portuguese ruler agreed to make an exception and permitted the Spanish to attempt the conquest of Melilla. The duke sent Pedro Estopinan who conquered the city virtually without a fight in 1497, as internal conflicts had depleted it of troops, and its defenses were weakened. The Wattasid ruler Muhammad al-Shaykh sent a detachment of cavalrymen to retake control of the city, but they were repulsed by the guns of the Spanish ships. 
 Question: What happened first: The Conquest of Melilla or Treaty of Alcacovaz?
Output: treaty of alcáçovaz
Context: The Draco Dwarf is a spheroidal galaxy which was discovered by Albert George Wilson of Lowell Observatory in 1954 on photographic plates of the National Geographic Society's Palomar Observatory Sky Survey (POSS). 
 Question: The discovery date or year of Draco Dwarf is?
Output: 1954
Context: According to the latest research in the United States,men and women talk such different languages that it is like people from two different cultures trying to communicate.Professor Deborah Tannen of Georgetown University has noticed the difference in the style of boys' and girls' conversations from an early age.She says that little girls' conversation is less definite than boys' and expresses more doubts.Little boys use conversations to establish status with their listeners. These differences continue into adult life,she says.In public conversations,men talk most and interrupt other speakers more.In private conversations,men and women speak in equal amounts--although they say things in a different style.Professor Tannen believes that,for women,private talking is a way to establish and test intimacy(,).For men,private talking is a way to explore the power structure of a relationship. Teaching is one job where the differences between men's and women's ways of talking show.When a man teaches a woman,says Professor Tannen,he wants to show that he has more knowledge,and hence(,)more power in conversation.When a woman teaches another woman,however,she is more likely to take a sharing approach and to encourage her student to join in. But Professor Tannen does not believe that women are naturally more helpful.She says women feel they achieve power by being able to help others.Although the research suggests men talk and interrupt people more than women,Professor Tannen says,women actually encourage this to happen because they believe it will lead to more intimacy and help to establish a relationship. Some scientists who are studying speech think that the brain is pre-programmed for language.As we are usually taught to speak by women,it seems that the brain must have a sexual bias in its programming,otherwise male speech patterns would not arise at all. 
 Question: There are in little girls' conversation than in boys'.
Output: more doubts
Context: According to 2011 census of India, Kumbakonam had a population of 140,156 with a sex-ratio of 1,021 females for every 1,000 males, much above the national average of 929. A total of 12,791 were under the age of six, constituting 6,495 males and 6,296 females.The average literacy of the city was 83.21%, compared to the national average of 72.99%. There were a total of 9,519 workers, comprising 32 cultivators, 83 main agricultural labourers, 1,206 in house hold industries, 7,169 other workers, 1,029 marginal workers, 24 marginal cultivators, 45 marginal agricultural labourers, 212 marginal workers in household industries and 0 other marginal workers. 
 Question: Which group were there more workers of, house hold industries or marginal workers in household industries?
Output: house hold industries
Context: According to the market research firm SuperData, as of May 2015, the global games market was worth USD 74.2 billion. By region, North America accounted for $23.6 billion, Asia for $23.1 billion, Europe for $22.1 billion and South America for $4.5 billion. By market segment, mobile games were worth $22.3 billion, retail games 19.7 billion, free-to-play Massively multiplayer online game 8.7 billion, social games $7.9 billion, PC Downloadable content 7.5 billion, and other categories $3 billion or less each. 
 Question: Which region accounted for more of SuperData's wealth, Asia or Europe?
Output: asia
Context: New treatment options are urgently needed for patients with relapsed chronic lymphocytic leukemia (CLL) who fail to respond to currently available therapies or cannot achieve a sustained response. Moreover, targeted agents with less myelotoxicity are necessary to treat patients with multiple comorbidities who would otherwise be unable to tolerate standard regimens. Ibrutinib, a Bruton's tyrosine kinase inhibitor, has shown highly encouraging results in phase I/II trials in patients with treatment-naive, relapsed and refractory CLL even in the presence of high risk disease or poor prognostic markers. In phase I/II trials, ibrutinib 420 mg or 840 mg - given continuously as single agent or at a dose of 420 mg daily in combination with a monoclonal antibody or chemoimmunotherapy - has been associated with high response rates and durable clinical remissions. Phase II and III trials are currently under way for treatment-naive patients, relapsed/refractory patients, and for those patients harboring a 17p deletion. 
 Question: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?
Output: ibrutinib
Context: Mortimer Dormer Leggett (April 19, 1821 -- January 6, 1896) was a lawyer, school administrator, professor, and major general of the Union Army during the American Civil War. 
 Question: Which entity was Mortimer Dormer Leggett a part of?
Output: union army
Context: Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor B ligand (RANKL) has been identified as a pivotal paracrine mediator of progesterone function in mouse mammary gland development and mammary carcinogenesis. Whether the factor has the same role in humans is of clinical interest because an inhibitor for RANKL, denosumab, is already used for the treatment of bone disease and might benefit breast cancer patients. We show that progesterone receptor (PR) signaling failed to induce RANKL in PR(+) breast cancer cell lines and in dissociated, cultured breast epithelial cells. In clinical specimens from healthy donors and intact breast tissue microstructures, hormone response was maintained and RANKL expression was under progesterone control, which increased RNA stability. RANKL was sufficient to trigger cell proliferation and was required for progesterone-induced proliferation. The findings were validated in vivo where RANKL protein expression in the breast epithelium correlated with serum progesterone levels and the protein was expressed in a subset of luminal cells that express PR. Thus, important hormonal control mechanisms are conserved across species, making RANKL a potential target in breast cancer treatment and prevention. 
 Question: To the ligand of which receptors does Denosumab (Prolia) bind?
Output: rankl
Context: Maxence Bibie (11 January 1891 - 24 May 1950) was a French politician. 
 Question: Which language or languages is Maxence Bibie fluent in?
Output: french
Context: Organisms are individual living things. They range from microscopic bacteria to gigantic blue whales (see Figure must be obtained from the environment. Biotic factors are all of the living or once-living aspects of the environment. They include all the organisms that live there as well as the remains of dead organisms. Abiotic factors are all of the aspects of the environment that have never been alive. They include factors such as sunlight, minerals in soil, temperature, and moisture. Ecologists study organisms and environments at several different levels, from the individual to the biosphere. The levels are depicted in Figure 23.2 and described below. For a video introduction to the levels of organization in ecology, click on this link: . MEDIA Click image to the left or use the URL below. URL: An individual is an organism, or single living thing. A population is a group of individuals of the same species that live in the same area. Members of the same population generally interact with each other. A community is made up of all the populations of all the species that live in the same area. Populations in a community also generally interact with each other. 
 Question: __all the populations of all the species that live in the same area
Output: community
Context: In follicular lymphoma, a chromosomal translocation commonly occurs between the fourteenth and the eighteenth chromosomes -- t(14;18) -- which places the Bcl-2 gene from chromosome 18 next to the immunoglobulin heavy chain locus on chromosome 14. 
 Question: Which chromosone can you find Bcl-2?
Output: chromosome 18
Context: As of the 2010 United States Census, there were 1,951,269 people, 715,365 households, and 467,916 families residing in the county. The population density was . There were 840,343 housing units at an average density of . The racial makeup of the county was 60.9% white, 10.5% black or African American, 8.7% Asian, 0.7% Pacific islander, 0.7% American Indian, 13.5% from other races, and 5.1% from two or more races. Those of Hispanic or Latino origin made up 29.1% of the population. In terms of ancestry, 11.7% were Germans, 9.1% were Irish people, 7.6% were English people, 6.3% were Italians, and 2.7% were Americans. 
 Question: Was more of the population English or Italian?
Output: english
Context: Restless legs syndrome (RLS) has gradually been recognized as a cause for insomnia in adults, but there have been few reports about children with RLS in Japan. Here we described seven pediatric RLS patients. All of the parents of our patients had difficult times to make their children sleep due to irritability, restlessness, and demanding bedtime routines. All patients had asked their parents to rub their feet in bed, and it took more than half an hour to soothe them until they fell asleep. Their mothers had been exhausted from this night-time routine. However, they did not consider the routine abnormal, as it had been their habitual behavior since infancy. Some parents were too distressed or embarrassed to describe the symptoms of their child properly. Five patients had clear family history and none had obvious periodic leg movements during sleep. All patients showed low levels of ferritin and iron supplementation was effective in five cases. In the severest two cases, pramipexole, but not iron, was dramatically effective. Both patients started to show RLS symptoms in the early days of infancy, which may suggest more severe hereditary dopaminergic dysfunction. RLS does occur in childhood and pediatricians should bear it in mind as one of the differential diagnoses when seeing children who are irritated and/or having difficulty in initiating their sleep. 
 Question: Which deficiency is the cause of restless leg syndrome?
Output: iron
Context: While I was waiting to enter university,I saw advertised in a local newspaper a teaching post at a school in a suburb of London about ten miles from where I lived. Being very short of money, I applied. Three days later, a letter arrived, asking me to go to Croydon for an interview. It proved a tiring journey: a train to Croydon station; a ten-minute bus ride and then a walk of at least fifteen minutes. It was clearly the headmaster himself that opened the door. He was short and fat, with a grey-color1ed moustache,a deeply lined face and hardly any hair. He looked at me with surprised disapproval. Then he said. "You'd better come inside." Leading me into his study, he started to ask me a number of questions: what subjects I had taken in my General School Certificate;how old I was; what games I played; whether I thought games were an important part of a boy's education, etc. I said something about not attaching too much importance to them. We obviously had very little in common. The teaching arrangement filled me with fear. I was to divide the class of twenty-four boys, aged from seven to thirteen, into three groups and teach them all subjects--including art, football, cricket and so on--in turn at three different levels. Actually, I was depressed at the thought of teaching algebra and geometry--two subjects in which I had been rather weak at school. I said shyly, "What would my salary be?" "Twelve pounds a week plus lunch." Before I could speak, he got to his feet. "Now," he said, "you'd better meet my wife. She's the one who really runs this school." This was the last thing I could hear. I was young. How could my dignity allow me to work under an old woman? 
 Question: Which subjects was the writer poor at?
Output: algebra and geometry,
Context: at the Georgia Dome, Atlanta, Georgia Trying to end a three-game skid, the Falcons returned home for an NFC South rematch with the New Orleans Saints. From the get-go, the Falcons trailed as in the first quarter, QB Drew Brees completed a 76-yard TD pass to WR Devery Henderson, while RB Deuce McAllister got a 1-yard TD run. Atlanta would respond with kicker Morten Andersen kicking a 22-yard field goal. In the second quarter, Andersen gave the Falcons a 30-yard field goal, yet New Orleans continued dominating with Brees completing an incredible 48-yard TD pass to WR Terrance Copper on the very last offensive play of the half. In the third quarter, RB Warrick Dunn gave Atlanta some room to operate, as he a 1-yard TD run for the only score of the half. However, in the fourth quarter, the Saints wrapped up the game with kicker John Carney getting a 25-yard field goal, while McAllister got a 9-yard TD run. After the game, as QB Michael Vick was leaving the field, he flicked off an insulting fan with both hands. He was fined $10,000 from the NFL and had to donate another $10,000 to charity. With their fourth-straight loss, the Falcons fell to 5-6. 
 Question: Who scored first
Output: saints
Context: In 2009 Fukushimas industries directly employed 18,678 workers and shipped 671 billion worth of goods. This was led by information-related industries with 50.5% of total output. Other industries in Fukushima include those dealing with food at 7.6% of total output, metals at 7.5%, chemistry at 5.3%, ceramics at 4.9%, electricity at 4.5%, printed goods at 2.8%, steel at 2.5%, plastics at 2.5%, and electronics at 2.2%. Other various industries make up the final 9.8%. 
 Question: What industries made up the largest percentage?
Output: information-related industries