niryuu/sni-each-converted huggingface dataset:
Context: Imatinib mesylate (Glivec) is a selective inhibitor of bcr-abl tyrosine kinase, the product of the Philadelphia chromosome, which is the hallmark of chronic myeloid leukaemia (CML). With imatinib, complete cytogenetic response (CCR) can be achieved in over 70% of newly diagnosed patients with CML. However, the optimal long-term management of patients who achieve CCR after imatinib is unknown. With longer follow-up, it is anticipated that some patients are likely to progress and become candidates for autologous transplantation. We studied filgrastim (r-metHuG-CSF) mobilisation of peripheral blood stem cells (PBSC) in 32 patients who have achieved CCR with imatinib. Our data demonstrate that (1) the target CD34(+) cell yields of >/=2.0 x 10(6)/kg were attained with filgrastim 10 microg/kg/day, in 9/18 (50%) of patients during uninterrupted imatinib therapy, and in 10/14 (70%) when imatinib was temporarily withheld. The median CD34(+) cell yield per aphaeresis was 0.70 x 10(6)/kg (range 0.14-2.18) and 2.90 x 10(6)/kg (range 0.15-8.71) in the two groups, respectively (P&<0.005). (2) The cell yields did not correlate with the duration of imatinib administration. (3) There was no impact of the mobilisation procedure on the level of leukaemia as measured by serial blood bcr-abl levels using real-time quantitative PCR with either protocol. (4) bcr-abl remained detectable at low levels in the harvests in most but not all patients. In conclusion, filgrastim can safely be used to mobilise PBSC in patients who have achieved CCR with imatinib, but CD34(+) cell yields are significantly improved when imatinib is temporarily withheld. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Miles Monroe (Woody Allen), a jazz musician and owner of the "Happy Carrot" health-food store in 1973, is subjected to cryopreservation without his consent, and not revived for 200 years.[2] The scientists who revive him are members of a rebellion: 22nd-century America seems to be a police state, ruled by a dictator about to implement a secret plan known as the "Aries Project". The rebels hope to use Miles as a spy to infiltrate the Aries Project, because he is the only member of this society without a known biometric identity. The authorities discover the scientists' project, and arrest them. Miles escapes by disguising himself as a robot, and goes to work as a butler in the house of socialite Luna Schlosser (Diane Keaton). When Luna decides to have his head replaced with something more "aesthetically pleasing," Miles reveals his true identity to her, whereupon Luna threatens to give Miles to the authorities. In response, he kidnaps her and goes on the run, searching for the Aries Project. Miles and Luna fall in love, but Miles is captured and brainwashed into becoming a complacent member of the society, while Luna joins the rebellion. The rebels kidnap Miles and perform reverse-brainwashing, whereupon he remembers his past and joins their efforts. Miles becomes jealous when he catches Luna kissing the rebel leader, Erno Windt (John Beck), and she tells him that she believes in free love. Miles and Luna infiltrate the Aries Project, wherein they quickly learn that the national leader had been killed by a rebel bomb ten months previously. All that survives is his nose. Other members of the Aries Project, mistaking Miles and Luna for doctors, expect them to clone the leader from this single remaining part. Miles steals the nose and "assassinates" it by dropping it in the path of a road roller. After escaping, Miles and Luna debate their future together. He tells her that Erno will inevitably become as corrupt as the Leader. Miles and Luna confess their love for one another, but she claims that science has proven men and women cannot have meaningful relationships due to chemical incompatibilities. Miles dismisses this, saying that he does not believe in science, and Luna points out that he does not believe in God or political systems either. Luna asks Miles if there is anything he does believe in, and he responds with the line, "Sex and deathtwo things that come once in a lifetimebut at least after death you're not nauseous."[3] The film ends as the two embrace. 
 Question: Who catches onto the scientists' project?
Output: the police or the authorities
Context: Miles Monroe (Woody Allen), a jazz musician and owner of the "Happy Carrot" health-food store in 1973, is subjected to cryopreservation without his consent, and not revived for 200 years.[2] The scientists who revive him are members of a rebellion: 22nd-century America seems to be a police state, ruled by a dictator about to implement a secret plan known as the "Aries Project". The rebels hope to use Miles as a spy to infiltrate the Aries Project, because he is the only member of this society without a known biometric identity. The authorities discover the scientists' project, and arrest them. Miles escapes by disguising himself as a robot, and goes to work as a butler in the house of socialite Luna Schlosser (Diane Keaton). When Luna decides to have his head replaced with something more "aesthetically pleasing," Miles reveals his true identity to her, whereupon Luna threatens to give Miles to the authorities. In response, he kidnaps her and goes on the run, searching for the Aries Project. Miles and Luna fall in love, but Miles is captured and brainwashed into becoming a complacent member of the society, while Luna joins the rebellion. The rebels kidnap Miles and perform reverse-brainwashing, whereupon he remembers his past and joins their efforts. Miles becomes jealous when he catches Luna kissing the rebel leader, Erno Windt (John Beck), and she tells him that she believes in free love. Miles and Luna infiltrate the Aries Project, wherein they quickly learn that the national leader had been killed by a rebel bomb ten months previously. All that survives is his nose. Other members of the Aries Project, mistaking Miles and Luna for doctors, expect them to clone the leader from this single remaining part. Miles steals the nose and "assassinates" it by dropping it in the path of a road roller. After escaping, Miles and Luna debate their future together. He tells her that Erno will inevitably become as corrupt as the Leader. Miles and Luna confess their love for one another, but she claims that science has proven men and women cannot have meaningful relationships due to chemical incompatibilities. Miles dismisses this, saying that he does not believe in science, and Luna points out that he does not believe in God or political systems either. Luna asks Miles if there is anything he does believe in, and he responds with the line, "Sex and deathtwo things that come once in a lifetimebut at least after death you're not nauseous."[3] The film ends as the two embrace. 
 Question: Who catches onto the scientists' project?
Output: the authorities
Context: The Patriots clinched their fourth straight AFC East title with a close road win. After a scoreless first quarter, the Jaguars responded to a Gostkowski field goal with a Maurice Jones-Drew touchdown run. The Patriots challenged the play, as Jones-Drew appeared to fall down at the line of scrimmage, but the ruling on the field was upheld. New England came back before the halftime to retake the lead at 10-7 on a Dillon one-yard touchdown run. The Patriots maintained their lead as the teams traded touchdowns in the second half, including another touchdown by Jones-Drew. A David Garrard fumble with 1:55 left in the fourth quarter, recovered by safety Rodney Harrison, sealed the Patriots' 11th win of the season. 
 Question: Which team scored the most in the first half?
Output: new england
Context: Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by Philadelphia chromosome and resultant production of the constitutively activated BCR-ABL tyrosine kinase. Imatinib (STI571), selective inhibitor of the ABL-tyrosine kinase, inhibits the activity of BCR-ABL tyrosine kinase. A phase I and II study of STI571 showed remarkable cytogenetic effect in patients with interferon-refractory CML, offering new hope for therapy for CML. It will, however, require long-term follow-up data from phase II and III clinical studies to validate the effect of STI571 on survival. As therapy for CML improves, monitoring minimal residual disease will be important. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Different rock types weather at different rates. Certain types of rock are very resistant to weathering. Igneous rocks, especially intrusive igneous rocks such as granite, weather slowly because it is hard for water to penetrate them. Other types of rock, such as limestone, are easily weathered because they dissolve in weak acids. Rocks that resist weathering remain at the surface and form ridges or hills. Shiprock in New Mexico is the throat of a volcano thats left after the rest of the volcano eroded away. The rock thats left behind is magma that cooled relatively slowly and is harder than the rock that had surrounded it. Different minerals also weather at different rates. Some minerals in a rock might completely dissolve in water, but the more resistant minerals remain. In this case, the rocks surface becomes pitted and rough. When a less resistant mineral dissolves, more resistant mineral grains are released from the rock. A beautiful example of this effect is the "Stone Forest" in China, see the video below: The Shiprock formation in northwest New Mexico is the central plug of resistant lava from which the surrounding rock weath- ered and eroded away. Click image to the left or use the URL below. URL: A regions climate strongly influences weathering. Climate is determined by the temperature of a region plus the amount of precipitation it receives. Climate is weather averaged over a long period of time. Chemical weathering increases as: Temperature increases: Chemical reactions proceed more rapidly at higher temperatures. For each 10o C increase in average temperature, the rate of chemical reactions doubles. Precipitation increases: More water allows more chemical reactions. Since water participates in both mechan- ical and chemical weathering, more water strongly increases weathering. So how do different climates influence weathering? A cold, dry climate will produce the lowest rate of weathering. A warm, wet climate will produce the highest rate of weathering. The warmer a climate is, the more types of vegetation it will have and the greater the rate of biological weathering (Figure 1.2). This happens because plants and bacteria grow and multiply faster in warmer temperatures. Some resources are concentrated by weathering processes. In tropical climates, intense chemical weathering carries away all soluble minerals, leaving behind just the least soluble components. The aluminum oxide, bauxite, forms this way and is our main source of aluminum ore. 
 Question: climate is determined by
Output: temperature
Context: 7,8-Dihydro-8-oxoguanine (8-oxoG) is the most frequent mutagenic lesion caused by oxidative stress. Eukaryotic cells use a specific DNA glycosylase, OGG1, to excise 8-oxoG from DNA. The mild phenotype of OGG1 null mice has been attributed to the existence of alternative pathways, including Cockayne syndrome B (CSB)-dependent transcription coupled repair (TCR), for removal of 8-oxoG. We have studied repair and transcription activities at 8-oxoG lesions with a reconstituted transcription system (RTS; RNA polymerase II, TBP, TFIIA, TFIIB, TFIIE, TFIIF and TFIIH), as well as in cellular extracts and in vivo. All measurable repair activity at 8-oxoG lesions takes place in the 3'-direction from the lesion, indicating base excision repair (BER) activity and negligible role of nucleotide excision repair (NER). Although 8-oxoG has been shown to be preferentially removed from the transcribed strand, in vitro experiments with purified transcription factors failed to identify a definite block for RNA polymerase II at the lesion. However, a weak block was observed at the lesion during transcription carried out with RTS as well as with cellular extracts. RNA polymerase II was identified at the site of the lesion on obstructed templates. Wild-type cells, as well as cells carrying targeted mutations of genes required for removal of 8-oxoG, were transfected with a luciferase expression vector containing an 8-oxoG lesion. No significant obstruction at 8-oxoG lesions was observed by this in vivo approach. In control experiments transcription elongation was completely blocked by cisplatin. 
 Question: Which gene strand is targeted by transcription-coupled repair (TCR)?
Output: the transcribed strand
Context: In early September 2004, amid internal turmoil, the remnants of Otpor! merged into the Democratic Party led by Boris Tadic. 
 Question: What year was the end of Otpor!?
Output: september 2004
Context: The Damned United is a 2009 British sports drama film directed by Tom Hooper and adapted by Peter Morgan from David Peace's bestselling novel The Damned Utd, a largely fictional book based on the author's interpretation of Brian Clough's ill-fated tenure as football manager of Leeds United in 1974. 
 Question: Who id the director for The Damned United?
Output: tom hooper
Context: Extrusive igneous rocks cool at the surface. Volcanoes are one type of feature that forms from extrusive rocks. Several other interesting landforms are also extrusive features. Intrusive igneous rocks cool below the surface. These rocks do not always remain hidden. Rocks that formed in the crust are exposed when the rock and sediment that covers them is eroded away. When lava is thick, it flows slowly. If thick lava makes it to the surface, it cannot flow far from the vent. It often stays right in the middle of a crater at the top of a volcano. Here the lava creates a large, round lava dome (Figure A lava plateau is made of a large amount of fluid lava. The lava flows over a large area and cools. This creates a large, flat surface of igneous rock. Lava plateaus may be huge. The Columbia Plateau covers over 161,000 square kilometers (63,000 square miles). It makes up parts of the states of Washington, Oregon, and Idaho. Thin, fluid lava created the rock that makes up the entire ocean floor. This is from multiple eruptions from vents at the mid-ocean ridge. While not exactly a lava plateau, its interesting to think about so much lava! New land is created in volcanic eruptions. The Hawaiian Islands are shield volcanoes. These volcanoes formed from fluid lava (Figure 8.21). The island grows as lava is added on the coast. New land may also emerge from lava that erupts from beneath the water. This is one way that new land is created. Magma that cools underground forms intrusions (Figure 8.22). Intrusions become land formations if they are exposed at the surface by erosion. Water works its way through porous rocks or soil. Sometimes this water is heated by nearby magma. If the water makes its way to the surface, it forms a hot spring or a geyser. When hot water gently rises to the surface, it creates a hot spring. A hot spring forms where a crack in the Earth allows water to reach the surface after being heated underground. Many hot springs are used by people as natural hot tubs. Some people believe that hot springs can cure illnesses. Hot springs are found all over the world, even in Antarctica! Geysers are also created by water that is heated beneath the Earths surface. The water may become superheated by magma. It becomes trapped in a narrow passageway. The heat and pressure build as more water is added. When the pressure is too much, the superheated water bursts out onto the surface. This is a geyser. There are only a few areas in the world where the conditions are right for the formation of geysers. Only about 1,000 geysers exist worldwide. About half of them are in the United States. The most famous geyser is Old Faithful at Yellowstone National Park (Figure 8.23). It is rare for a geyser to erupt so regularly, which is why Old Faithful is famous. 
 Question: Examples of lava plateaus include the
Output: columbia plateau.
Context: Many pieces of evidence can mean that a volcano is about to erupt, but the time and magnitude of the eruption are difficult to pin down. This evidence includes the history of previous volcanic activity, earthquakes, slope deformation, and gas emissions. A volcanos history how long since its last eruption and the time span between its previous eruptions is a good first step to predicting eruptions. Active and dormant volcanoes are heavily monitored, especially in populated areas. Moving magma shakes the ground, so the number and size of earthquakes increases before an eruption. A volcano that is about to erupt may produce a sequence of earthquakes. Scientists use seismographs that record the length and strength of each earthquake to try to determine if an eruption is imminent. Magma and gas can push the volcanos slope upward. Most ground deformation is subtle and can only be detected by tiltmeters, which are instruments that measure the angle of the slope of a volcano. But ground swelling may sometimes create huge changes in the shape of a volcano. Mount St. Helens grew a bulge on its north side before its 1980 eruption. Ground swelling may also increase rock falls and landslides. Gases may be able to escape a volcano before magma reaches the surface. Scientists measure gas emissions in vents on or around the volcano. Gases, such as sulfur dioxide (SO2 ), carbon dioxide (CO2 ), hydrochloric acid (HCl), and even water vapor can be measured at the site (Figure 1.1) or, in some cases, from a distance using satellites. The amounts of gases and their ratios are calculated to help predict eruptions. Scientists monitoring gas emissions at Mount St. Helens. Some gases can be monitored using satellite technology (Figure 1.2). Satellites also monitor temperature readings and deformation. As technology improves, scientists are better able to detect changes in a volcano accurately and safely. Since volcanologists are usually uncertain about an eruption, officials may not know whether to require an evac- uation. If people are evacuated and the eruption doesnt happen, the people will be displeased and less likely to evacuate the next time there is a threat of an eruption. The costs of disrupting business are great. However, scientists continue to work to improve the accuracy of their predictions. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL: 
 Question: magma and gas building up in a magma chamber before an eruption cause
Output: ground deformation
Context: A change in an objects motionsuch as Xander speeding up on his scooteris called acceleration. Acceleration occurs whenever an object is acted upon by an unbalanced force. The greater the net force acting on the object, the greater its acceleration will be, but the mass of the object also affects its acceleration. The smaller its mass is, the greater its acceleration for a given amount of force. Newtons second law of motion summarizes these relationships. According to this law, the acceleration of an object equals the net force acting on it divided by its mass. This can be represented by the equation: Acceleration = Net force Mass or a = F m This equation for acceleration can be used to calculate the acceleration of an object that is acted on by a net force. For example, Xander and his scooter have a total mass of 50 kilograms. Assume that the net force acting on Xander and the scooter is 25 Newtons. What is his acceleration? Substitute the relevant values into the equation for acceleration: F = 25 N = 0.5 N a= m 50 kg kg The Newton is the SI unit for force. It is defined as the force needed to cause a 1-kilogram mass to accelerate at 1 m/s2 . Therefore, force can also be expressed in the unit kg m/s2 . This way of expressing force can be substituted for Newtons in Xanders acceleration so the answer is expressed in the SI unit for acceleration, which is m/s2 : 2 0.5 kgm/s a = 0.5kgN = = 0.5 m/s2 kg Q: Why are there no kilograms in the final answer to this problem? A: The kilogram units in the numerator and denominator of the fraction cancel out. As a result, the answer is expressed in the correct SI units for acceleration. Its often easier to measure the mass and acceleration of an object than the net force acting on it. Mass can be measured with a balance, and average acceleration can be calculated from velocity and time. However, net force may be a combination of many unseen forces, such as gravity, friction with surfaces, and air resistance. Therefore, it may be more useful to know how to calculate the net force acting on an object from its mass and acceleration. The equation for acceleration above can be rewritten to solve for net force as: Net Force = Mass Acceleration, or F=ma Look at Xander in the Figure 1.1. Hes riding his scooter down a ramp. Assume that his acceleration is 0.8 m/s2 . How much force does it take for him to accelerate at this rate? Substitute the relevant values into the equation for force to find the answer: F = m a = 50 kg 0.8 m/s2 = 40 kg m/s2 , or 40 N Q: If Xander and his scooter actually had a mass of 40 kg instead of 50 kg, how much force would it take for him to accelerate at 0.8 m/s2 ? 
 Question: for a given net force, an object will accelerate less if it has a greater
Output: mass.
Context: The first U.S. multicenter clinical trial to assess the performance of the Cepheid Xpert MRSA assay (Xpert MRSA) was conducted. The assay is a qualitative test designed for the rapid detection of methicillin-resistant Staphylococcus aureus (MRSA) directly from nares swabs. This novel test combines integrated nucleic acid extraction and automated real-time PCR for the detection of a MRSA-specific signature sequence. A total of 1,077 nares specimens were collected from seven geographically distinct health care sites across the United States with prevalence rates ranging from 5.2% to 44%. Nares specimens were tested by (i) the Xpert MRSA assay, (ii) direct culture on CHROMagar MRSA medium (direct CM culture), and (iii) broth-enriched culture (Trypticase soy broth with 6.5% sodium chloride) followed by plating onto CHROMagar MRSA medium (broth-enriched CM culture). When direct CM culture was designated the reference method, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the Xpert MRSA assay were 94.3%, 93.2%, 73.0%, and 98.8%, respectively. When broth-enriched CM culture was used as the reference method, the clinical sensitivity, specificity, PPV, and NPV of the Xpert MRSA assay were 86.3%, 94.9%, 80.5%, and 96.6%, respectively. The BD GeneOhm MRSA (BDGO) assay was performed as a comparative molecular method. No statistical performance differences were observed between the Xpert MRSA and BDGO assays when they were compared to culture methods. From this large-scale, multicenter clinical comparison, we conclude that the Xpert MRSA assay is a simple, rapid, and accurate method for performing active surveillance for MRSA in a variety of health care populations. 
 Question: What is MRSA?
Output: mrsa
Context: The first U.S. multicenter clinical trial to assess the performance of the Cepheid Xpert MRSA assay (Xpert MRSA) was conducted. The assay is a qualitative test designed for the rapid detection of methicillin-resistant Staphylococcus aureus (MRSA) directly from nares swabs. This novel test combines integrated nucleic acid extraction and automated real-time PCR for the detection of a MRSA-specific signature sequence. A total of 1,077 nares specimens were collected from seven geographically distinct health care sites across the United States with prevalence rates ranging from 5.2% to 44%. Nares specimens were tested by (i) the Xpert MRSA assay, (ii) direct culture on CHROMagar MRSA medium (direct CM culture), and (iii) broth-enriched culture (Trypticase soy broth with 6.5% sodium chloride) followed by plating onto CHROMagar MRSA medium (broth-enriched CM culture). When direct CM culture was designated the reference method, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the Xpert MRSA assay were 94.3%, 93.2%, 73.0%, and 98.8%, respectively. When broth-enriched CM culture was used as the reference method, the clinical sensitivity, specificity, PPV, and NPV of the Xpert MRSA assay were 86.3%, 94.9%, 80.5%, and 96.6%, respectively. The BD GeneOhm MRSA (BDGO) assay was performed as a comparative molecular method. No statistical performance differences were observed between the Xpert MRSA and BDGO assays when they were compared to culture methods. From this large-scale, multicenter clinical comparison, we conclude that the Xpert MRSA assay is a simple, rapid, and accurate method for performing active surveillance for MRSA in a variety of health care populations. 
 Question: What is MRSA?
Output: methicillin-resistant s. aureus
Context: One of the most recent social changes taking place in the world is social networking. Social networking has been in existence for at least 150 years, and probably longer than that. In the times before the invention of the computer and the World Wide Web (WWW), social networking was done in person. People who had similar likes and interests would gather together to share experiences, make new friends, and improve their businesses. On the Internet, social networking websites made their first appearances during the late 1990s. The first major social networking website in the United States was MySpace. MySpace allowed its users to exchange messages, share pictures, and make new friends in a way that was never thought of in the past. With MySpace, people who did not go out much could reach out to others from their own homes. In 2004, Facebook was created. It was first a website created for use by Harvard University's students and teachers, but it soon expanded to include just about everyone. It is now larger than some of the largest companies in the world. It is a website that is changing all the time. Facebook has completely changed the way people stay connected with each other and the rest of the world. The way it works is simple. Users can set up a new account easily. All a new user needs is an email address to start. Once a person has created an account and his friend also has his own Facebook page, he can invite his friend by sending a request out to him. Once you get started, making new friends will come easily. 
 Question: What do new users of Facebook need to create an account?
Output: an email address.
Context: Oxford's Department for Continuing Education runs over 1000 courses per year, offered on a part-time basis. Programmes include Oxford awards and degrees at undergraduate and postgraduate level, online short courses, weekly classes, day and weekend events, continuing professional development and summer schools. Oxford awards & degrees Over 50 undergraduate and postgraduate Oxford qualifications: certificates, diplomas, advanced diplomas, Master's and Doctoral degrees, offered part-time, in the arts, social sciences, diplomatic studies, human rights law, health care and biomedical sciences, which involve overseas students. Course duration ranges from one year to several years part-time. The Department also runs a Graduate School to provide the support and guidance needed by those following part-time graduate programmes. www.conted.ox.ac.uk/qualifications Online & distance learning Choose from over 90 courses across a range of disciplines. Most are short courses of 5-10 weeks, accredited (officially approved). A few longer courses result in Oxford qualifications. www.conted.ox.ac.uk/online Weekly classes Approximately 500 part-time accredited classes, open to all, and held in Oxford, Reading and other locations. Topics are studied in depth over a period of 10 or 20 weeks. www.conted.ox.ac.uk/weekly Day & weekend events Courses of 1 or 2 days, usually held at weekends and taught by lecturers and speakers who are noted authorities in their field of research. Many courses are offered in combination with national organizations. Over 150 offered per year. www.conted.ox.ac.uk/dayweekend Professional development courses 200 courses per year, ranging from day schools to short refresher courses to full degree programmes. Subjects include health sciences, public policy, diplomatic studies, nanotechnology, electronics, historic conservation, environmental sciences, public administration, higher education leadership and more. www.conted.ox.ac.uk/cpd Summer schools Accredited and non-accredited courses of between one and three weeks, with over 120 to choose from. Most are designed for the general public; others are designed to allow professionals to update skills. www.conted.ox.ac.uk/summerschools 
 Question: Which website is useful to foreign students?
Output: www.conted.ox.ac.uk/qualifications
Context: Coming off their come-from-behind win over the Dolphins, the Broncos traveled to Arrowhead Stadium for an AFC West rematch with the Kansas City Chiefs. The Broncos jumped out to a 14-0 lead on their first two possessions in the first quarter, with quarterback Peyton Manning throwing a pair of touchdown passes a 23-yarder to wide receiver Demaryius Thomas and a 15-yarder to running back C. J. Anderson. A 22-yard field goal by placekicker Connor Barth increased the Broncos' lead to 17-0 early in the second quarter. The scoring play occurred after the Broncos' special teams fooled the Chiefs with a fake punt run by safety David Bruton and a fourth-down conversion by Anderson. The Chiefs got on the scoreboard later in the second quarter, with quarterback Alex Smith connecting on a 20-yard touchdown pass to tight end Anthony Fasano. The Broncos' offense subsequently marched down the field, but had to settle on a 24-yard field goal by Barth just before halftime. The Chiefs' defense forced a fumble off Manning deep in Broncos' territory on the Broncos' first possession of the second half, but had to settle on a 39-yard field goal by placekicker Cairo Santos. Barth added two more field goals a 30-yarder midway through the third quarter and a 33-yarder early in the fourth quarter to increase the Broncos' lead to 26-10. The first field goal came after a DeMarcus Ware interception of Smith on a deflected pass, while the second field goal came after Chiefs' cornerback Marcus Cooper muffed a punt. The Chiefs narrowed the Broncos' lead, with Smith throwing a 12-yard touchdown pass to running back Jamaal Charles. However, Broncos' safety T. J. Ward knocked away a two-point conversion pass from Smith intended for Fasano that would have brought the Chiefs to within a one-score deficit. Barth added one more field goal a 37-yarder midway through the fourth quarter. The Broncos' defense subdued the Chiefs for the remainder of the game. With the win, the Broncos swept the Chiefs for a third consecutive season. Peyton Manning improved his personal record to 11-1 all-time in games against the Chiefs. 
 Question: What was the closest field goal to 25 yards?
Output: 24-yard
Context: Nguyen Van Bay (Born in Lai Vung, 1936) was a jet fighter ace for the Vietnam People's Air Force (North Vietnamese Air Force) during the Vietnam War. 
 Question: What was the war that Nguyen Van Bay fought in?
Output: vietnam war
Context: Sir Wilfred Robarts, a famed barrister, has just been released from the hospital in which he stayed for two months following a heart attack. Returning to his practise of law, he takes the case of Leonard Vole, an unemployed man who is accused of murdering his elderly friend, Mrs. Emily French. Vole claims he's innocent, although all evidence points to him as the killer, but his alibi witness, his cold German wife Christine, instead of entering the court as a witness for the defense, becomes the witness for the prosecution and defiantly testifies that her husband is guilty of the murder. Sir Wilfred believes there's something suspicious going on with the case, particularly with Mrs. Vole. 
 Question: Who announces that he will defend Christine in her trial for murder?
Output: sir wilfrid robarts
Context: Sir Wilfred Robarts, a famed barrister, has just been released from the hospital in which he stayed for two months following a heart attack. Returning to his practise of law, he takes the case of Leonard Vole, an unemployed man who is accused of murdering his elderly friend, Mrs. Emily French. Vole claims he's innocent, although all evidence points to him as the killer, but his alibi witness, his cold German wife Christine, instead of entering the court as a witness for the defense, becomes the witness for the prosecution and defiantly testifies that her husband is guilty of the murder. Sir Wilfred believes there's something suspicious going on with the case, particularly with Mrs. Vole. 
 Question: Who announces that he will defend Christine in her trial for murder?
Output: sir wilfred
Context: Sir Wilfred Robarts, a famed barrister, has just been released from the hospital in which he stayed for two months following a heart attack. Returning to his practise of law, he takes the case of Leonard Vole, an unemployed man who is accused of murdering his elderly friend, Mrs. Emily French. Vole claims he's innocent, although all evidence points to him as the killer, but his alibi witness, his cold German wife Christine, instead of entering the court as a witness for the defense, becomes the witness for the prosecution and defiantly testifies that her husband is guilty of the murder. Sir Wilfred believes there's something suspicious going on with the case, particularly with Mrs. Vole. 
 Question: How long did Sir Wilfred Robarts stay at the hospital?
Output: two months
Context: Extrusive igneous rocks cool at the surface. Volcanoes are one type of feature that forms from extrusive rocks. Several other interesting landforms are also extrusive features. Intrusive igneous rocks cool below the surface. These rocks do not always remain hidden. Rocks that formed in the crust are exposed when the rock and sediment that covers them is eroded away. When lava is thick, it flows slowly. If thick lava makes it to the surface, it cannot flow far from the vent. It often stays right in the middle of a crater at the top of a volcano. Here the lava creates a large, round lava dome (Figure A lava plateau is made of a large amount of fluid lava. The lava flows over a large area and cools. This creates a large, flat surface of igneous rock. Lava plateaus may be huge. The Columbia Plateau covers over 161,000 square kilometers (63,000 square miles). It makes up parts of the states of Washington, Oregon, and Idaho. Thin, fluid lava created the rock that makes up the entire ocean floor. This is from multiple eruptions from vents at the mid-ocean ridge. While not exactly a lava plateau, its interesting to think about so much lava! New land is created in volcanic eruptions. The Hawaiian Islands are shield volcanoes. These volcanoes formed from fluid lava (Figure 8.21). The island grows as lava is added on the coast. New land may also emerge from lava that erupts from beneath the water. This is one way that new land is created. Magma that cools underground forms intrusions (Figure 8.22). Intrusions become land formations if they are exposed at the surface by erosion. Water works its way through porous rocks or soil. Sometimes this water is heated by nearby magma. If the water makes its way to the surface, it forms a hot spring or a geyser. When hot water gently rises to the surface, it creates a hot spring. A hot spring forms where a crack in the Earth allows water to reach the surface after being heated underground. Many hot springs are used by people as natural hot tubs. Some people believe that hot springs can cure illnesses. Hot springs are found all over the world, even in Antarctica! Geysers are also created by water that is heated beneath the Earths surface. The water may become superheated by magma. It becomes trapped in a narrow passageway. The heat and pressure build as more water is added. When the pressure is too much, the superheated water bursts out onto the surface. This is a geyser. There are only a few areas in the world where the conditions are right for the formation of geysers. Only about 1,000 geysers exist worldwide. About half of them are in the United States. The most famous geyser is Old Faithful at Yellowstone National Park (Figure 8.23). It is rare for a geyser to erupt so regularly, which is why Old Faithful is famous. 
 Question: flat surface of igneous rock that forms when thin lava flows over a large area
Output: lava plateau
Context: Gene expression signatures can provide an unbiased view into the molecular changes underlying biologically and medically interesting phenotypes. We therefore initiated this study to identify signatures that would be of utility in studying rheumatoid arthritis (RA). We used microarray profiling of peripheral blood mononuclear cells (PBMCs) in 30 RA patients to assess the effect of different biologic agent (biologics) treatments and to quantify the degree of a type-I interferon (IFN) signature in these patients. A numeric score was derived for the quantification step and applied to patients with RA. To further characterize the IFN response in our cohort, we employed type-I IFN treatment of PBMCs in vitro and in reporter assays. Profiling identified a subset of RA patients with upregulation of type-I IFN-regulated transcripts, thereby corroborating previous reports showing RA to be heterogeneous for an IFN component. A comparison of individuals currently untreated with a biologic with those treated with infliximab, tocilizumab, or abatacept suggested that each biologic induces a specific gene signature in PBMCs. It is possible to observe signs of type-I IFN pathway activation in a subset of clinically active RA patients without C-reactive protein elevation. Furthermore, biologics-specific gene signatures in patients with RA indicate that looking for a biologic-specific response pattern may be a potential future tool for predicting individual patient response. 
 Question: Which is the most common gene signature in Rheumatoid Arthritis patients?
Output: ifn signature
Context: Gene expression signatures can provide an unbiased view into the molecular changes underlying biologically and medically interesting phenotypes. We therefore initiated this study to identify signatures that would be of utility in studying rheumatoid arthritis (RA). We used microarray profiling of peripheral blood mononuclear cells (PBMCs) in 30 RA patients to assess the effect of different biologic agent (biologics) treatments and to quantify the degree of a type-I interferon (IFN) signature in these patients. A numeric score was derived for the quantification step and applied to patients with RA. To further characterize the IFN response in our cohort, we employed type-I IFN treatment of PBMCs in vitro and in reporter assays. Profiling identified a subset of RA patients with upregulation of type-I IFN-regulated transcripts, thereby corroborating previous reports showing RA to be heterogeneous for an IFN component. A comparison of individuals currently untreated with a biologic with those treated with infliximab, tocilizumab, or abatacept suggested that each biologic induces a specific gene signature in PBMCs. It is possible to observe signs of type-I IFN pathway activation in a subset of clinically active RA patients without C-reactive protein elevation. Furthermore, biologics-specific gene signatures in patients with RA indicate that looking for a biologic-specific response pattern may be a potential future tool for predicting individual patient response. 
 Question: Which is the most common gene signature in Rheumatoid Arthritis patients?
Output: interferon signature
Context: Elizabeth Blackwell was born in England in 1821, and moved to New York City when she was ten years old. One day she decided that she wanted to become a doctor. That was nearly impossible for a woman in the middle of the nineteenth century. After writing many letters asking for admission to medical schools, she was finally accepted by a doctor in Philadelphia. She was so determined that she taught school and gave music lessons to get money for the cost of schooling. In 1849, after graduation from medical school, she decided to further her education in Paris. She wanted to be a surgeon , but a serious eye problem forced her to give up the idea. Upon returning to the United States, she found it difficult to start her own practice because she was a woman. By 1857 Elizabeth and her sister, also a doctor, along with another woman doctor, managed to open a new hospital, the first for women and children. Besides being the first woman physician and founding her own hospital , she also set up the first medical school for women. 
 Question: What main obstacle almost destroyed Elizabeth's chances for becoming a doctor?
Output: she was a woman.
Context: In Week 8, the Bears donned their 1940s throwback uniforms against the Carolina Panthers, who had the worst record in the NFC. The Bears scored first on Matt Forte's 13-yard touchdown run, which would be countered by Justin Medlock's 34-yard field goal. The Panthers then took the lead on Louis Murphy's fumble recovery; Panthers quarterback Cam Newton ran with the ball, and lost the ball when Bears safety Major Wright tackled him at the 1-yard line. The ball rolled into the endzone, where Murphy recovered it. Medlock would then kick three more field goals, and by the fourth quarter, the Panthers led 19-7. The tide eventually turned when Panthers punter Brad Nortman shanked a 6-yard punt, and Jay Cutler hit Kellen Davis on a 12-yard touchdown pass with less than seven minutes left in the game. On the first play of the Panthers' next drive, Tim Jennings intercepted Newton and returned the pick 25 yards to regain the lead 20-19, after Cutler's two-point conversion passing attempt was intercepted. Medlock later kicked another field goal to reclaim the lead 22-20 with 2:27 left in the game. Cutler would lead the Bears downfield, and Gould kicked a 41-yard field goal as time expired to give Chicago the victory. The kick was Gould's tenth game-winning field goal, and the first since 2010. 
 Question: Which player scored more field goals, Justin Medlock or Gould?
Output: justin medlock
Context: In the Caucasus region of Russia, nearly 50 out of every 100,000 people live to celebrate their 100th birthday, and many don't stop at 100! By comparison, in America only 3 people in 100,000 reach 100. But these Russian old people aren't alone. The Pakistanis, who live high in the Himalaya Mountains, and the Ecuadorans of the Andes Mountains seem to share the secret of long life, too. These people remain healthy in body and spirit despite the passage of time. While many older persons in industrial societies become weak and ill in their 60s and 70s, some Caucasians aged 100 to 140, work in the fields beside their great-great-grandchildren. Even the idea of aging is foreign to them. When asked "at what age does youth end?"most of these old people had no answer. Several replied, "Well, perhaps at age 80." What accounts for this ability to survive to such old age, and to survive so well?First of all, hard physical work is a way of life for all of these long-lived people. They begin their long days of physical labor as children and never seem to stop. For example, Mr . Rustam Mamedov is 142 years of age. His wife is 116 years old. They have been married for 90 years. Mr. Mamedov has no intention of retiring from his life as a farmer. "Why?What else would I do?"he asks. All these people get healthful rewards from the environment in which they work. They all come from mountainous regions. They live and work at elevations of 1,660 to 1,000 meters above sea level. The air has less oxygen and is pollution-free. This reduced-oxygen environment makes the heart and blood vessel system stronger. Another factor that may contribute to the good health of these people is their isolation. To a great extent, they are separated from the pressures and worries of industrial society. Inherited factors also play some role. Most of the longest-lived people had parents and grandparents who also reached very old ages. Good family genes may, therefore, be one factor in living longer. 
 Question: What is the main way of life for all of these long-lived people?
Output: hard physical work.
Context: A rock under enough stress will fracture. There may or may not be movement along the fracture. If there is no movement on either side of a fracture, the fracture is called a joint. The rocks below show horizontal and vertical jointing. These joints formed when the confining stress was removed from the rocks as shown in (Figure If the blocks of rock on one or both sides of a fracture move, the fracture is called a fault (Figure 1.2). Stresses along faults cause rocks to break and move suddenly. The energy released is an earthquake. How do you know theres a fault in this rock? Try to line up the same type of rock on either side of the lines that cut across them. One side moved relative to the other side, so you know the lines are a fault. Slip is the distance rocks move along a fault. Slip can be up or down the fault plane. Slip is relative, because there is usually no way to know whether both sides moved or only one. Faults lie at an angle to the horizontal surface of the Earth. That angle is called the faults dip. The dip defines which of two basic types a fault is. If the faults dip is inclined relative to the horizontal, the fault is a dip-slip fault (Figure 1.3). There are two types of dip-slip faults. In a normal fault, the hanging wall drops down relative to the footwall. In a reverse fault, the footwall drops down relative to the hanging wall. This diagram illustrates the two types of dip-slip faults: normal faults and reverse faults. Imagine miners extracting a re- source along a fault. The hanging wall is where miners would have hung their lanterns. The footwall is where they would have walked. A thrust fault is a type of reverse fault in which the fault plane angle is nearly horizontal. Rocks can slip many miles along thrust faults (Figure 1.4). At Chief Mountain in Montana, the upper rocks at the Lewis Overthrust are more than 1 billion years older than the lower rocks. How could this happen? Normal faults can be huge. They are responsible for uplifting mountain ranges in regions experiencing tensional stress. A strike-slip fault is a dip-slip fault in which the dip of the fault plane is vertical. Strike-slip faults result from shear stresses. Imagine placing one foot on either side of a strike-slip fault. One block moves toward you. If that block moves toward your right foot, the fault is a right-lateral strike-slip fault; if that block moves toward your left foot, the fault is a left-lateral strike-slip fault (Figure 1.5). Californias San Andreas Fault is the worlds most famous strike-slip fault. It is a right-lateral strike slip fault (See opening image). People sometimes say that California will fall into the ocean someday, which is not true. Strike-slip faults. Click image to the left or use the URL below. URL: 
 Question: mountain ranges can uplift on these types of faults.
Output: normal faults
Context: James De La Vega was born in East Harlem, the son of Jaime De La Vega and Elsie Matos, and graduated valedictorian at York Preparatory School and attended Cornell University, where he graduated in 1994 with a Bachelor of Fine Arts. 
 Question: What is the name university that educated James De La Vega?
Output: cornell university