niryuu/sni-each-converted huggingface dataset:
Context: In his will, Sugarman provided for the establishment of The George Sugarman Foundation, Inc. A 1934 graduate of the City College of New York, Sugarman served in the United States Navy from 1941 to 1945, assigned to the Pacific theater. 
 Question: What is the name university that educated George Sugarman?
Output: city college of new york
Context: James Dargaville (born 25 April 1992) is an Australian rugby union footballer who currently plays as a wing for the Brumbies in Super Rugby. 
 Question: What is the position James Dargaville plays in football?
Output: wing
Context: Mandy Hering (born 11 March 1984) is a German handball player. 
 Question: To which sports is Mandy Hering related?
Output: handball
Context: zfhz1b is the causative gene for Mowat-Wilson syndrome, in which patients demonstrate developmental delay and Hirschsprung disease, as well as other anomalies. We identified a patient with Mowat-Wilson syndrome who also developed cholestasis and histopathologic features consistent with biliary atresia, suggesting that mutations involving zfhz1b may lead to biliary developmental anomalies or injury to the biliary tract. We used the zebrafish model system to determine whether zfhx1b has a role in vertebrate biliary development. Using zebrafish we determined that zfhx1b was expressed in the developing liver during biliary growth and remodeling, and that morpholino antisense oligonucleotide-mediated knockdown of zfhx1b led to defects in biliary development. These findings were associated with decreased expression of vhnf1, a transcription factor known to be important in biliary development in zebrafish and in mammals. Our studies underscore the importance of genetic contributions in the etiology of infantile hepatobiliary disorders, including biliary atresia. 
 Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Output: zeb2
Context: zfhz1b is the causative gene for Mowat-Wilson syndrome, in which patients demonstrate developmental delay and Hirschsprung disease, as well as other anomalies. We identified a patient with Mowat-Wilson syndrome who also developed cholestasis and histopathologic features consistent with biliary atresia, suggesting that mutations involving zfhz1b may lead to biliary developmental anomalies or injury to the biliary tract. We used the zebrafish model system to determine whether zfhx1b has a role in vertebrate biliary development. Using zebrafish we determined that zfhx1b was expressed in the developing liver during biliary growth and remodeling, and that morpholino antisense oligonucleotide-mediated knockdown of zfhx1b led to defects in biliary development. These findings were associated with decreased expression of vhnf1, a transcription factor known to be important in biliary development in zebrafish and in mammals. Our studies underscore the importance of genetic contributions in the etiology of infantile hepatobiliary disorders, including biliary atresia. 
 Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Output: zfhx1b
Context: zfhz1b is the causative gene for Mowat-Wilson syndrome, in which patients demonstrate developmental delay and Hirschsprung disease, as well as other anomalies. We identified a patient with Mowat-Wilson syndrome who also developed cholestasis and histopathologic features consistent with biliary atresia, suggesting that mutations involving zfhz1b may lead to biliary developmental anomalies or injury to the biliary tract. We used the zebrafish model system to determine whether zfhx1b has a role in vertebrate biliary development. Using zebrafish we determined that zfhx1b was expressed in the developing liver during biliary growth and remodeling, and that morpholino antisense oligonucleotide-mediated knockdown of zfhx1b led to defects in biliary development. These findings were associated with decreased expression of vhnf1, a transcription factor known to be important in biliary development in zebrafish and in mammals. Our studies underscore the importance of genetic contributions in the etiology of infantile hepatobiliary disorders, including biliary atresia. 
 Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Output: sip-1
Context: Hyposmocoma menehune is a species of moth of the Cosmopterigidae family. 
 Question: Is Hyposmocoma menehune a genus or species?
Output: species
Context: Protective protein/cathepsin A (PPCA) has a serine carboxypeptidase activity of unknown physiological function. We now demonstrate that this protease activity triggers the degradation of the lysosome-associated membrane protein type 2a (lamp2a), a receptor for chaperone-mediated autophagy (CMA). Degradation of lamp2a is important because its level in the lysosomal membrane is a rate-limiting step of CMA. Cells defective in PPCA show reduced rates of lamp2a degradation, higher levels of lamp2a and higher rates of CMA. Restoration of PPCA protease activity increases rates of lamp2a degradation, reduces levels of lysosomal lamp2a and reduces rates of CMA. PPCA associates with lamp2a on the lysosomal membrane and cleaves lamp2a near the boundary between the luminal and transmembrane domains. In addition to the well-studied role of PPCA in targeting and protecting two lysosomal glycosidases, we have defined a role for the proteolytic activity of this multifunctional protein. 
 Question: Which is the receptor for substrates of Chaperone Mediated Autophagy?
Output: lamp2a
Context: Protective protein/cathepsin A (PPCA) has a serine carboxypeptidase activity of unknown physiological function. We now demonstrate that this protease activity triggers the degradation of the lysosome-associated membrane protein type 2a (lamp2a), a receptor for chaperone-mediated autophagy (CMA). Degradation of lamp2a is important because its level in the lysosomal membrane is a rate-limiting step of CMA. Cells defective in PPCA show reduced rates of lamp2a degradation, higher levels of lamp2a and higher rates of CMA. Restoration of PPCA protease activity increases rates of lamp2a degradation, reduces levels of lysosomal lamp2a and reduces rates of CMA. PPCA associates with lamp2a on the lysosomal membrane and cleaves lamp2a near the boundary between the luminal and transmembrane domains. In addition to the well-studied role of PPCA in targeting and protecting two lysosomal glycosidases, we have defined a role for the proteolytic activity of this multifunctional protein. 
 Question: Which is the receptor for substrates of Chaperone Mediated Autophagy?
Output: lysosome-associated membrane protein 2 isoform a
Context: The Steelers' ninth game was an AFC duel with the Patriots. The Steelers trailed early as QB Tom Brady made a 19-yard TD pass to TE Rob Gronkowski. This was followed by kicker Shayne Graham getting a 31-yard field goal. The Steelers responded in the second quarter with kicker Jeff Reed nailing a 22-yard field goal. The Steelers struggled further when Brady threw another TD pass to Gronkowski, this one from 9yards out. That was followed by Brady's scramble 3yards to the endzone for a touchdown (With a failed PAT as the kick went wide-right). The Steelers scored first in the 4th quarter when QB Ben Roethlisberger completed a 6-yard TD pass to WR Emmanuel Sanders. The Steelers looked to create another scoring drive, but it came to a halt when Roethlisberger's pass was intercepted by SS James Sanders and returned 32yards for a touchdown (With a failed 2-point conversion). The Steelers tried to cut the lead with a Roethlisberger 15-yard TD pass to WR Mike Wallace, but the Patriots replied with Brady getting a 25-yard TD pass to Gronkowski. Again the Steelers tried to get closer when Roethlisberger completed a 33-yard TD pass to Wallace, but the Patriots put the game away after Graham hit a 36-yard field goal. 
 Question: Who scored first
Output: patriots
Context: Wendy Craig (born 20 June 1934) is an English actress who is best known for her appearances in the sitcoms Not in Front of the Children, Butterflies, ... 
 Question: What is the birth date of Wendy Craig?
Output: 20 june 1934
Context: My grandmother often said to me, "You can count the number of your true friends on the fingers of one hand." For a long time I thought this was true. However, I've now discovered my grandmother was only half right. Maybe we do only make a few "best" friends in our lifetime, but those aren't the only people that we can call friends. There are many different types. Let me tell you about a few of them. One type of friends is the type I call the "football mom friend". My neighbor Sally is a good example. We both have kids who play football in a football club, and someone has to take them to practice and pick them up. Sally and I and two other mothers take turns to do this. We meet sometimes and have tea and talk about what our kids are doing, but those are the only times that we meet each other. I enjoy being with these women, but we don't do anything else together. Another type is called the "hobby friend". That's the person you share an interest or a hobby with. Michael and Cater, who are brothers, are a good example of this type. We're all in a bird watching club. Every few weekends the members of the club go on a trip to watch different kinds of birds. There's nothing romantic about my relationship with Michael and Cater, of course. We just share interest in birds. Then there's the "other half of the couple" type of friends. Jim is married to Rose, a friend that I've known since college. When Rose married Jim, I realized that I would have to be Jim's friend if I want to continue to be Rose's. Jim and I don't share so many interests, but we do have a friendly relationship. 
 Question: Many people are mentioned in this passage. Who is the writer's true friend?
Output: rose.
Context: Hoping to rebound from a divisional home loss to the Eagles, the Cowboys flew to Bank of America Stadium for a Week 16 Saturday night duel with the Carolina Panthers. In the first quarter, Dallas shot first with QB Tony Romo completing a 10-yard TD pass to WR Terrell Owens for the only score of the period. In the second quarter, the 'Boys continued their assault as RB Marion Barber got a 5-yard TD run. The Panthers would get on the board with QB Matt Moore completing an 11-yard TD pass to WR Steve Smith. The Cowboys end the half with rookie kicker Nick Folk getting a 42-yard field goal. In the third quarter, Carolina started to try a comeback as kicker John Kasay getting a 37-yard field goal for the only score of the period. In the fourth quarter, Dallas would respond with Folk kicking a 23-yard field goal. The Panthers tried to rally as Kasay nailing a 25-yard field goal, yet the 'Boys were able to hold off every possible attempt. With the win, the Cowboys improved to 13-2 and clinched homefield through NFC Playoffs with Green Bay's loss to Chicago on Sunday. Terrell Owens (5 receptions for 48 yards and 1 touchdown) left the game in the second quarter with a high left ankle sprain. 
 Question: Which player kicked both the longest and shortest field goals?
Output: nick folk
Context: Idarucizumab is a humanized monoclonal antibody fragment for reversal of the anticoagulant effects of dabigatran. This drug can be used for patients who need emergency surgery or invasive procedures, as well as those with life-threatening or uncontrolled bleeding. 
 Question: Which drug can be reversed with idarucizumab?
Output: dabigatran
Context: Peroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant protein in the erythrocyte, and its absence in knock-out mice gives rise to hemolytic anemia. We have found that in human erythrocytes, Prx2 was extremely sensitive to oxidation by H(2)O(2), as dimerization was observed after exposure of 5 x 10(6) cells/mL to 0.5 muM H(2)O(2). In contrast to Prx2 in Jurkat T lymphocytes, Prx2 was resistant to overoxidation (oxidation of the cysteine thiol to a sulfinic/sulfonic acid) in erythrocytes. Reduction of dimerized Prx2 in the erythrocyte occurred very slowly, with reversal occurring gradually over a 20-minute period. Very low thioredoxin reductase activity was detected in hemolysates. We postulate that this limits the rate of Prx2 regeneration, and this inefficiency in recycling prevents the overoxidation of Prx2. We also found that Prx2 was oxidized by endogenously generated H(2)O(2), which was mainly derived from hemoglobin autoxidation. Our results demonstrate that in the erythrocyte Prx2 is extremely efficient at scavenging H(2)O(2) noncatalytically. Although it does not act as a classical antioxidant enzyme, its high concentration and substrate sensitivity enable it to handle low H(2)O(2) concentrations efficiently. These unique redox properties may account for its nonredundant role in erythrocyte defense against oxidative stress. 
 Question: What type of enzyme is peroxiredoxin 2 (PRDX2)?
Output: antioxidant
Context: It's time to be water efficient! As populations increase across Australia and the rest of the world, demand for water will also increase. If we don't reduce each individual's demand for water (both directly and through embodied water) the water situation will become dire. It is obvious that we cannot increase demands for water much more without detrimental effects to the environment, society and the economy. It's all too easy to blame someone else for the water situation -"if 70% of water is used for agriculture then that's what we should target" - but it's not that easy. We all depend on the food and resources that agriculture provides, and while there are definitely opportunities to increase water efficiency on the farm, the solution will take more than that. We each share responsibility for the sustainable management of our water resources, which means using less water at home, in the workplace, at school, on holidays, on the farm, ... everyone, everywhere, every time. It's time to become water efficient! This involves reassessing our relationship with water, and learning to use it more sparingly. On the most basic level, it requires a behavioural change, and assigning a value to water that truly reflects its worth. We can also unlock economic benefits of being water efficient. There are many real world examples given in the case studies on this site. Everybody has a responsibility to save water, if future generations are to enjoy a similar standard of living to the one we enjoy now. In fact, many of the impacts associated with water use are likely to have an effect on our own lives! www.savewater.com.au has been designed to help you respond to the challenge to become water efficient. It acts as a central repository for relevant information and further advice, so that you can actually achieve significant savings. It also showcases those companies with products that will assist you in your goal. 
 Question: What is the main idea of this passage?
Output: it's time to be water efficient.
Context: The Rams started their season on the road against the Lions. The Rams drew first blood in the first quarter with a 48-yard field goal from Greg Zuerlein to take a 3-0 lead for the only score of that quarter. The Lions then took a 7-3 lead with Joique Bell's 1-yard run for a touchdown in the 2nd quarter. The Rams responded with a 29-yard field goal from Zuerlein as they came up within a point 7-6 before on the Lions' next possession, Matthew Stafford was picked off by Cortland Finnegan and it was returned 31 yards for a touchdown as the Rams retook the lead 13-7. The Lions then responded with Jason Hanson kicking a 41-yard field goal to shorten the Rams' lead to 13-10 at halftime. After the break, the Lions scored first with Jason Hanson kicking a 45-yard field goal to tie the game 13-13 for the only score of the 3rd quarter. However, the Rams moved back into the lead in the 4th quarter with Brandon Gibson's 23-yard catch from Sam Bradford to make it 20-13. The Lions tied the game back up with Kevin Smith running for a touchdown from 5 yards out to tie the game 20-20. The Rams then retook the lead with Greg Zuerlein kicking a 46-yard field goal to make the score 23-20. On their last possession, the Lions moved down the field and Matthew Stafford found Kevin Smith on a 5-yard touchdown pass to make the final score 27-23 as the Rams began their season 0-1. 
 Question: Who threw the longest touchdown pass?
Output: sam bradford
Context: Branko Cvetkovic (born 5 March 1984) is a Serbian professional basketball player for Tadamon Zouk of the Lebanese Basketball League. 
 Question: Which sport does/did Branko Cvetkovic play?
Output: basketball
Context: The Capitol Skyline Hotel is a hotel located near the United States Capitol in Capitol Hill, Washington, D.C. Designed by Morris Lapidus, the hotel opened in November 1962 as the Skyline Inn, and was once part of the Best Western chain. 
 Question: Who was the architect or designer of Capitol Skyline Hotel?
Output: morris lapidus
Context: Autosomal-recessive hereditary spastic paraplegias (AR-HSP) consist of a genetically diverse group of neurodegenerative diseases characterised by pyramidal tracts dysfunction. The causative genes for many types of AR-HSP remain elusive. We tried to identify the gene mutation for AR-HSP with cerebellar ataxia and neuropathy. This study included two patients in a Japanese family with their parents who are first cousins. Neurological examination and gene analysis were conducted in the two patients and two normal family members. We undertook genome-wide linkage analysis employing single nucleotide polymorphism arrays using the two patients' DNAs and exome sequencing using one patient's sample. We detected a homozygous missense mutation (c.4189T>G, p.F1397V) in the lysosomal trafficking regulator (LYST) gene, which is described as the causative gene for Chediak-Higashi syndrome (CHS). CHS is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction. This mutation was co-segregated with the disease in the family and was located at well-conserved amino acid. This LYST mutation was not found in 200 Japanese control DNAs. Microscopic observation of peripheral blood in the two patients disclosed large peroxidase-positive granules in both patients' granulocytes, although they had no symptoms of immune deficiency or bleeding tendency. We diagnosed these patients as having adult CHS presenting spastic paraplegia with cerebellar ataxia and neuropathy. The clinical spectrum of CHS is broader than previously recognised. Adult CHS must be considered in the differential diagnosis of AR-HSP. 
 Question: Which mutated gene causes the ChediakHigashi Syndrome?
Output: lysosomal trafficking regulator gene
Context: Autosomal-recessive hereditary spastic paraplegias (AR-HSP) consist of a genetically diverse group of neurodegenerative diseases characterised by pyramidal tracts dysfunction. The causative genes for many types of AR-HSP remain elusive. We tried to identify the gene mutation for AR-HSP with cerebellar ataxia and neuropathy. This study included two patients in a Japanese family with their parents who are first cousins. Neurological examination and gene analysis were conducted in the two patients and two normal family members. We undertook genome-wide linkage analysis employing single nucleotide polymorphism arrays using the two patients' DNAs and exome sequencing using one patient's sample. We detected a homozygous missense mutation (c.4189T>G, p.F1397V) in the lysosomal trafficking regulator (LYST) gene, which is described as the causative gene for Chediak-Higashi syndrome (CHS). CHS is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction. This mutation was co-segregated with the disease in the family and was located at well-conserved amino acid. This LYST mutation was not found in 200 Japanese control DNAs. Microscopic observation of peripheral blood in the two patients disclosed large peroxidase-positive granules in both patients' granulocytes, although they had no symptoms of immune deficiency or bleeding tendency. We diagnosed these patients as having adult CHS presenting spastic paraplegia with cerebellar ataxia and neuropathy. The clinical spectrum of CHS is broader than previously recognised. Adult CHS must be considered in the differential diagnosis of AR-HSP. 
 Question: Which mutated gene causes the ChediakHigashi Syndrome?
Output: lyst gene
Context: Elena Wexler-Kreindler (15 October 1931 -- August 2002) was a Romanian mathematician. 
 Question: The date of birth of Elena Wexler-Kreindler is?
Output: 15 october 1931
Context: To identify the origin and study the morphology of small supernumerary marker chromosome (sSMC) in Turner syndrome with 45, X/46, X, + mar karyotype. Using the conventional chromosome G-banding technique, 10 cases of Turner syndrome with 45, X/46, X, + mar chromosome karyotype were obtained, dual-color fluorescence in situ hybridization was applied to study the origin and morphology of the sSMC. In the 10 cases of Turner syndrome with 45, X/46, X, + mar karyotype, the sSMC of 7 cases was derived from X chromosome [sSMC(X)], the sSMC of 2 cases was derived from Y chromosome [sSMC(Y)] and the remaining 1 case was derived from the autosome. There were 4 cases of ring(r) chromosomes and 3 of centric minutes (min) in the 7 sSMC (X) cases. In the 2 sSMC(Y), one case was dicentric (dic) and the other was centric minute (min). The sSMC originated from the autosome was a centric minute (min). The origin of sSMC of Turner syndrome with 45, X/46, X, + mar karyotype was almost all from sex chromosomes, and rarely from autosomes. sSMC can exist as isodicentric, ring, or centric minute. The molecular cytogenetic features of the sSMC can provide useful information for genetic counseling, prenatal diagnosis and treatment of the Turner syndrome patients with a 45, X/46, X, + mar karyotype. 
 Question: What chromosome is affected in Turner's syndrome?
Output: x
Context: A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as a mechanism for the treatment of autoimmune diseases such as asthma, rheumatoid arthritis, and SLE. Fostamatinib, a Syk inhibitor that successfully completed phase II clinical trials, also exhibits some undesirable side effects. More selective Syk inhibitors could offer safer, alternative treatments. Through a systematic evaluation of the kinome, we identified Pro455 and Asn457 in the Syk ATP binding site as a rare combination among sequence aligned kinases and hypothesized that optimizing the interaction between them and a Syk inhibitor molecule would impart high selectivity for Syk over other kinases. We report the structure-guided identification of three series of selective spleen tyrosine kinase inhibitors that support our hypothesis and offer useful guidance to other researchers in the field. 
 Question: Which enzyme is inhibited by a drug fostamatinib?
Output: spleen tyrosine kinase
Context: Chronic liver injury can result in fibrosis that may progress over years to end-stage liver disease. The most effective anti-fibrotic therapy is treatment of the underlying disease, however when not possible, interventions to reverse or slow fibrosis progression are needed. The aim of this study was to study the safety and tolerability of simtuzumab, a monoclonal antibody directed against lysyl oxidase-like 2 (LOXL2) enzyme, in subjects with hepatitis C virus (HCV), human immunodeficiency virus (HIV), or HCV-HIV co-infection and advanced liver disease. Eighteen subjects with advanced liver fibrosis received simtuzumab 700 mg intravenously every 2 weeks for 22 weeks. Transjugular liver biopsies were performed during screening and at the end of treatment to measure hepatic venous pressure gradient (HVPG) and to stage fibrosis. Treatment was well-tolerated with no discontinuations due to adverse events. No significant changes were seen in HVPG or liver biopsy fibrosis score after treatment. Exploratory transcriptional and protein profiling using paired pre- and post-treatment liver biopsy and serum samples suggested up-regulation of TGF-3 and IL-10 pathways with treatment. In this open-label, pilot clinical trial, simtuzumab treatment was well-tolerated in HCV- and HIV-infected subjects with advanced liver disease. Putative modulation of TGF-3 and IL-10 pathways during simtuzumab treatment merits investigation in future trials. 
 Question: What is the drug target for Simtuzumab?
Output: loxl2
Context: The Spiritual Exercises of Ignatius of Loyola (Latin original: Exercitia spiritualia) (composed 1522--1524) are a set of Christian meditations, prayers and mental exercises, written by Saint Ignatius of Loyola, a 16th-century Spanish priest, theologian, and founder of the Society of Jesus (Jesuits). 
 Question: What group was Spiritual Exercises of Ignatius of Loyola a member of?
Output: society of jesus
Context: An earthquake is sudden ground movement caused by the sudden release of energy stored in rocks. Earthquakes happen when so much stress builds up in the rocks that the rocks rupture. The energy is transmitted by seismic waves. Earthquakes can be so small they go completely unnoticed, or so large that it can take years for a region to recover. The description of how earthquakes occur is called elastic rebound theory (Figure 1.1). Elastic rebound theory. Stresses build on both sides of a fault, causing the rocks to deform plastically (Time 2). When the stresses become too great, the rocks break and end up in a different location (Time 3). This releases the built up energy and creates an earthquake. Click image to the left or use the URL below. URL: In an earthquake, the initial point where the rocks rupture in the crust is called the focus. The epicenter is the point on the land surface that is directly above the focus (Figure 1.2). In the vertical cross section of crust, there are two features labeled - the focus and the epicenter, which is directly above the focus. Click image to the left or use the URL below. URL: 
 Question: when an earthquake happens, we say that its __________ was located 100 miles northwest of san francisco.
Output: epicenter
Context: Starting lineups: HOUSTON - OFFENSE: QB Matt Schaub, LT Duane Brown, LG Wade Smith, C Chris Myers, RG Mike Brisiel, RT Eric Winston, WR Andre Johnson, RB Arian Foster, FB Vonta Leach, TE Joel Dreessen, WR Kevin Walter.Hoping to snap a four-game losing streak the Texans played on home ground for an AFC South rivalry match against the Titans. The Texans took control throughout the game as QB Matt Schaub got a 1-yard TD pass to TE Joel Dreessen, followed by his 2-yard TD pass to WR Andre Johnson. The lead was increased when kicker Neil Rackers hit a 35 and a 33-yard field goal. With the easy win, the Texans improved to 5-6. However, Johnson was ejected following a fight with Titans CB Cortland Finnegan, who was also ejected. 
 Question: Who kicked the longest field goal?
Output: neil rackers
Context: This categorises Stahlgewitter in amongst other more historical Rock Against Communism groups such as the English band Skrewdriver which played a lending role in the formation of RAC and the fellow German band Landser who are now deemed a ''criminal gang organisation'' in Germany. 
 Question: What is the city of origin of Stahlgewitter?
Output: germany
Context: Intravenous immunoglobulin (IVIG) has shown limited promise so far in human clinical studies on Alzheimer's disease (AD), yet overwhelmingly positive preclinical work in animals and human brain cultures support the notion that the therapy remains potentially efficacious. Here, we elaborate on IVIG neuropreservation by demonstrating that IVIG protects human primary neurons against oxidative stress in vitro and that IVIG preserves antioxidant defense mechanisms in vivo. Based on these results, we propose the following translational impact: If the dosage and treatment conditions are adequately optimized, then IVIG treatment could play a significant role in preventing and/or delaying the progression of neurodegenerative diseases, such as AD. We suggest that IVIG warrants further investigation to fully exploit its potential as an anti-oxidant, neuroprotective and synapto-protecting agent. 
 Question: What is the administration route of IVIG in Alzheimer's disease patients?
Output: intravenous
Context: William I of Hauteville (before 1010 -- 1046), known as William Iron Arm, was a Norman adventurer who was the founder of the fortunes of the Hauteville family. 
 Question: What family lineage was William Iron Arm part of?
Output: hauteville family
Context: The female reproductive organs include the vagina, uterus, fallopian tubes, and ovaries ( Figure 1.1). The breasts are not shown in this figure. They are not considered reproductive organs, even though they are involved in reproduction. They contain mammary glands that give milk to feed a baby. The milk leaves the breast through the nipple when the baby sucks on it. The vagina is a cylinder-shaped organ found inside of the female body. One end of the vagina opens at the outside of the body. The other end joins with the uterus. During sexual intercourse, sperm may be released into the vagina. If this occurs, the sperm will move through the vagina and into the uterus. During birth, a baby passes from the uterus to the vagina to leave the body. The uterus is a hollow organ with muscular walls. The part that connects the vagina with the uterus is called the cervix. The uterus is where a baby develops until birth. The walls of the uterus grow bigger as the baby grows. The muscular walls of the uterus push the baby out during birth. This drawing shows the organs of the female reproductive system. It shows the organs from the side. Find each organ in the drawing as you read about it in the text. The two ovaries are small, oval organs on either side of the uterus. Each ovary contains thousands of eggs, with about 1-2 million immature eggs present at birth and 40,000 immature eggs present at puberty, as most of the eggs die off. The eggs do not fully develop until a female has gone through puberty. About once a month, on average one egg completes development and is released by the ovary. The ovaries also secrete estrogen, the main female sex hormone. The two fallopian tubes are narrow tubes that open off from the uterus. Each tube reaches for one of the ovaries, but the tubes are not attached to the ovaries. The end of each fallopian tube by the ovary has fingers ( Figure 1.1). They sweep an egg into the fallopian tube. Then the egg passes through the fallopian tube to the uterus. If an egg is to be fertilized, this will occur in the fallopian tube. A fertilized egg then implants into the wall of the uterus, where it begins to develop. An unfertilized egg will flow through the uterus and be excreted from the body. 
 Question: where does a baby develop until birth?
Output: the uterus
Context: Huntley Gordon died in Van Nuys, California and was interred in the Forest Lawn Memorial Park Cemetery in Glendale, California. 
 Question: What is the place of burial for Huntley Gordon?
Output: forest lawn memorial park
Context: People should listen to music for no more than one hour a day to protect their hearing, the World Health Organization (WHO) suggests. It says 1.1 billion teenagers and young adults are at risk of permanently damaging their hearing by listening to "too much, too loudly". It said audio devices , concerts and bars were causing a "serious threat". WHO figures show 43 million people aged 12-35 have hearing loss and the number is increasing. In that age group, the WHO said, half of the people in rich and middle-income countries were exposed to unsafe sound levels from personal audio devices. Meanwhile 40% were exposed to damaging levels of sound from clubs and bars. The proportion of US teenagers with hearing loss went from 3.5% in 1994 to 5.3% in 2006. "What we're trying to do is raise awareness of the problem that is not talked about enough, but has the potential to do a lot of damage that can be easily prevented," said Dr Etienne Krug, the WHO's director for injury prevention. The full report argued: "While it is important to keep the volume down, limiting the use of personal audio devices to less than one hour a day would do much to reduce noise exposure." Dr Krug said: "That's a rough recommendation, it is not by the minute, to give an idea to those spending 10 hours a day listening to an mp3-player. But even an hour can be too much if the volume is too loud." 
 Question: How many people aged 12-35 were most likely to suffer from hearing loss according to WHO?
Output: 40%.
Context: The film explores adolescent issues through the minds of three friends and their reactions after a boy named Rudy Carges (Conor Donovan) is killed in a tree house set on fire by local bullies Jeff and Kenny, who carelessly didn't find out he was inside until too late. The boy's twin brother Jacob, a boy with a huge birthmark (also played by Donovan), decides to seek revenge against the bullies. Leonard (Jesse Camacho) who's overweight, survives the tree house fire but loses his sense of taste and smell. Thanks to the fire, this prompts Leonard to go on a diet, which isn't welcomed by his obese family. The boys' female friend Malee (Zoe Weizenbaum) tries to befriend an adult named Gus (Jeremy Renner), a grief-stricken patient of her therapist mother, Carla (Annabella Sciorra). Jacob's family falls apart after the death of his brother. But shortly after, his parents adopt a boy named Keith Gardner. Meanwhile, Malee begins to have a crush on Gus and changes the song for her recital to one Gus liked, just for him. As time goes by, she sees Gus as her "soul mate". She sneaks into his house one night to find him grieving. Afraid to confront him, Malee steals his gun and leaves. She gives it to Jacob the following day. Jacob frequently visits Jeff and Kenny, who are serving time in a juvenile hall. Jacob initially threatens them, until eventually Jeff commits suicide. Jacob befriends Kenny, soon learning he has an early release and is illegally moving to New Mexico. Meanwhile, Leonard's father decides to take his sisters to Florida instead of Leonard (who would usually go). Leonard decides to force his mother to lose weight by trapping her in the cellar. They both end up in the hospital after a gas leak in their home. Next, Jacob and Kenny agree that Jacob can go with him to New Mexico. Malee visits Gus and removes her clothes in an attempt to seduce him. Instead, Gus calls Malee's mother to come and pick her up. The next day, Gus explains to therapist Carla about the last fire he ever fought (which involved killing an injured little girl, upon the girl's request), claiming that Malee wanted him to take her pain away, as he was aware of her growing crush on him. Meanwhile, Jacob's mother tells him that Keith Gardner wasn't adopted to replace Rudy, and that she wants Kenny dead, which reminds Jacob of his planned revenge. The night of escape for Jacob finally comes and he meets up with Kenny. Jacob insists on going through a construction site which he says is a secret route. Once there, Jacob points Gus's gun at Kenny, and tells him "you killed him" before shooting him dead. Jacob buries the body and leaves. He returns in the daytime, and sees Gus spreading cement above Kenny's grave. Malee begins visiting her estranged father and Leonard's family finally starts eating healthily. The movie ends with Jacob's mother smiling at him from inside the house. 
 Question: Who does Rudy want to meet in the treehouse?
Output: leonard
Context: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancers are associated with increased sensitivity of these cancers to drugs that inhibit EGFR kinase activity such as gefitinib and erlotinib. Responses to TK inhibitors in the absence of EGFR gene mutation for BAC patients have not been reported. A case of a patient with BAC refractory to chemotherapy who responded to gefitinib in the absence of EGFR gene mutations is reported. Tyrosine kinase inhibitors may have a role in BAC in the absence of EGFR gene mutations. Additional studies on other molecular alterations of the EGFR family members are needed to better predict response to these agents. 
 Question: Mutations in which gene determine response to both erlotinib and gefitinib?
Output: epidermal growth factor receptor (egfr) gene
Context: The Chargers' fourteenth game was an interconference duel with the 49ers which was played on Thursday Night. The Chargers took a quick lead with QB Philip Rivers throwing a 58-yard TD pass to WR Vincent Jackson. The lead was extended in the second quarter by kicker Nate Kaeding nailing a 25-yard field goal, followed by Rivers finding Jackson on an 11-yard touchdown pass. The Chargers continued to dominate with FB Mike Tolbert getting a 1-yard TD run, followed by Rivers connecting to Jackson on a 48-yard TD pass, then with Kaeding hitting a 39-yard field goal. The 49ers made their only score of the game with RB Brian Westbrook getting a 1-yard TD run. This game was also a blowout and San Diego improved to 8-6. 
 Question: How many yards was the longest touchdown pass?
Output: 58-yard
Context: Christianson syndrome (OMIM 300243), caused by mutations in the X-linked SLC9A6 gene, is characterized by severe global developmental delay and intellectual disability, developmental regression, epilepsy, microcephaly and impaired ocular movements. It shares many common features with Angelman syndrome. Carrier females have been described as having learning difficulties with mild to moderate intellectual disability, behavioural issues and psychiatric illnesses. There is little literature on the carrier female phenotype of Christianson syndrome. We describe a large extended family with three affected males, four carrier females, one presumed carrier female and one obligate carrier female with a c.190G>T, p.E64X mutation known to cause a premature stop codon in SLC9A6. We characterize and expand the clinical phenotype of female SLC9A6 mutation carriers by comparing our described family with female carriers previously discussed in the literature. In particular, we highlight the neurodevelopmental and psychiatric phenotypes observed in our family and previous reports. 
 Question: Mutation of which gene is implicated in the Christianson syndrome?
Output: slc9a6
Context: Like water and carbon, nitrogen is also repeatedly recycled through the biosphere. This process is called the nitrogen cycle. Nitrogen is one of the most common elements in living organisms. It is important for creating both proteins and nucleic acids, like DNA. The air that we breathe is mostly nitrogen gas (N2 ), but, unfortunately, animals and plants cannot use the nitrogen when it is a gas. In fact, plants often die from a lack of nitrogen even through they are surrounded by plenty of nitrogen gas. Nitrogen gas (N2 ) has two nitrogen atoms connected by a very strong triple bond. Most plants and animals cannot use the nitrogen in nitrogen gas because they cannot break that triple bond. In order for plants to make use of nitrogen, it must be transformed into molecules they can use. This can be accomplished several different ways ( Figure 1.1). Lightning: When lightening strikes, nitrogen gas is transformed into nitrate (NO3 ) that plants can use. Nitrogen fixation: Special nitrogen-fixing bacteria can also transform nitrogen gas into useful forms. These bacteria live in the roots of plants in the pea family. They turn the nitrogen gas into ammonium (NH4 + ) (a process called ammonification). In water environments, bacteria in the water can also fix nitrogen gas into ammonium. Ammonium can be used by aquatic plants as a source of nitrogen. Nitrogen also is released to the environment by decaying organisms or decaying wastes. These wastes release nitrogen in the form of ammonium. Ammonium in the soil can be turned into nitrate by a two-step process completed by two different types of bacteria. In the form of nitrate, nitrogen can be used by plants through the process of assimilation. It is then passed along to animals when they eat the plants. Turning nitrate back into nitrogen gas, the process of denitrification, happens through the work of denitrifying bacteria. These bacteria often live in swamps and lakes. They take in the nitrate and release it back to the atmosphere as nitrogen gas. Just like the carbon cycle, human activities impact the nitrogen cycle. These human activities include the burning of fossil fuels, which release nitrogen oxide gasses into the atmosphere. Releasing nitrogen oxide back into the atmosphere leads to problems like acid rain. 
 Question: the initial step of producing a nitrogen containing compound from nitrogen in the soil is
Output: ammonification.
Context: Chronic myeloid leukaemia (CML) is a genetically associated malignancy of haematopoietic stem cells, characterized by a t(9;22) translocation that forms the Philadelphia chromosome and creates a novel fusion gene, BCR-ABL. Treatment with molecular-targeted therapy is usually initiated with imatinib, an inhibitor of BCR-ABL tyrosine kinase. Imatinib resistance is, however, observed in some CML patients, especially in those with advanced disease. Through computerized literature searches, a systematic analysis was conducted to examine the efficacy and benefits of dasatinib therapy for imatinib resistant or intolerant CML patients in the chronic phase (CP), accelerated phase (AP) and fatal blast crisis phase (BC). In terms of major haematological and cytogenetic responses, this meta-analysis showed no significant differences in dasatinib treatment between myeloid BC-CML and lymphoid BC-CML patients with imatinib resistance or intolerance. Dasatinib therapy was, however, significantly more effective in improving major haematological and cytogenetic responses for CP-CML patients than for AP-CML patients with imatinib resistance or intolerance. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: In week 11 following their bye-week, the Lions hosted the Jacksonville Jaguars. The Jaguars opened the scoring in the first quarter via a 27-yard field goal from Jason Myers. The Lions' first score came in the second quarter on a 55-yard punt return from Andre Roberts, but the extra point try by Matt Prater was partially blocked and failed. The Jaguars responded with a three-yard touchdown pass from Blake Bortles to Allen Robinson, but the conversion attempt by Myers also failed. The Lions then scored on a 27-yard field goal from Matt Prater, which tied the score at 9-9 at halftime. The Lions took the lead in the third quarter via a 39-yard interception return from Rafael Bush. The Jaguars responded with 10 points in the third quarter via a 52-yard field goal from Myers, and a three-yard touchdown pass from Bortles to Marqise Lee, giving them a 19-16 lead. The Lions, trailing for the ninth straight game when entering the fourth quarter, would score the final 10 points of the game. The Lions offense scored its first and only touchdown on a one-yard run from Eric Ebron, and Matt Prater added a 43-yard field goal with 22 seconds left in the game. On the final drive for the Jaguars, Tavon Wilson intercepted a pass from Bortles, sealing the Lions 26-19 victory. The Lions became the first team in NFL history to have its first ten games of a season all decided by seven or fewer points. 
 Question: Who scored first?
Output: jaguars
Context: Waking Ned (titled Waking Ned Devine in North America) is a 1998 comedy film by English writer and director Kirk Jones. 
 Question: Which is the publication date of Waking Ned?
Output: 1998
Context: Trying to snap a three-game losing streak, the 49ers flew to Giants Stadium for a Week 7 brawl with the New York Giants. With QB Alex Smith still recovering from a shoulder injury, back-up Trent Dilfer once again got the start. In the first quarter, the Niners trailed early as Giants QB Eli Manning hooked up with WR Amani Toomer on a 4-yard TD pass (with a missed PAT) for the only score of the period. In the second quarter, San Francisco took the lead with Dilfer completing a 17-yard TD pass to WR Arnaz Battle. However, New York responded with RB Brandon Jacobs getting a 5-yard TD run, while kicker Lawrence Tynes nailed field goals of 29 and 39 yards. In the third quarter, things got worse for the Niners as Giants DE Osi Umenyiora sacked Dilfer, causing a fumble, picked up the loose ball, and ran 75 yards for a touchdown. San Francisco would manage to get a safety as FB Moran Norris blocked a punt, which went out of bounds in the endzone. In the fourth quarter, New York sealed its win with Manning completing a 2-yard TD pass to TE Jeremy Shockey. The Niners ended its day with Dilfer completing a 1-yard TD pass to WR Darrell Jackson (with a failed 2-point conversion). 
 Question: Which receiver had the longest touchdown reception of the game?
Output: arnaz battle
Context: Gino Coutinho (born 5 August 1982) is a Dutch footballer, who plays as a goalkeeper for AZ in the Dutch Eredivisie. 
 Question: What position does Gino Coutinho play on the field?
Output: goalkeeper
Context: Coming off their special teams woes in 2010, the Chargers allowed a 103-yard opening kickoff return to Percy Harvin to start the season. Kicker Nate Kaeding suffered a season-ending injury on the play, and punter Mike Scifres assumed place kicking responsibilities for the game. The Chargers outscored the Vikings 10-0 in the fourth quarter to come back and win the game, 24-17. Fullback Mike Tolbert scored three touchdowns, and Philip Rivers completed 33 of 48 passes for 335 yards and two touchdowns. He was also intercepted twice. Scifres kicked a 40-yard field goal, the first of his NFL career, and kicked three PATs. With the win, the Chargers started their season out 1-0. 
 Question: Which player scored the longest touchdown of the game?
Output: percy harvin
Context: Sibton Abbey, an early Cistercian abbey located near Yoxford, Suffolk, was founded about 1150 by William de Chesney, High Sheriff of Norfolk and Suffolk. 
 Question: What group was Sibton Abbey a member of?
Output: cistercian
Context: The Steelers' ninth game was an AFC duel with the Patriots. The Steelers trailed early as QB Tom Brady made a 19-yard TD pass to TE Rob Gronkowski. This was followed by kicker Shayne Graham getting a 31-yard field goal. The Steelers responded in the second quarter with kicker Jeff Reed nailing a 22-yard field goal. The Steelers struggled further when Brady threw another TD pass to Gronkowski, this one from 9yards out. That was followed by Brady's scramble 3yards to the endzone for a touchdown (With a failed PAT as the kick went wide-right). The Steelers scored first in the 4th quarter when QB Ben Roethlisberger completed a 6-yard TD pass to WR Emmanuel Sanders. The Steelers looked to create another scoring drive, but it came to a halt when Roethlisberger's pass was intercepted by SS James Sanders and returned 32yards for a touchdown (With a failed 2-point conversion). The Steelers tried to cut the lead with a Roethlisberger 15-yard TD pass to WR Mike Wallace, but the Patriots replied with Brady getting a 25-yard TD pass to Gronkowski. Again the Steelers tried to get closer when Roethlisberger completed a 33-yard TD pass to Wallace, but the Patriots put the game away after Graham hit a 36-yard field goal. 
 Question: Who threw the longest touchdown pass of the game?
Output: roethlisberger