niryuu/sni-each-converted huggingface dataset:
Context: Alpha-synuclein accumulates in the brains of sporadic Parkinson's disease patients as a major component of Lewy bodies, and mutations in alpha-synuclein are associated with familial forms of Parkinson's disease. The pathogenic mechanisms that precede and promote the aggregation of alpha-synuclein into Lewy bodies in neurons remain to be determined. Here, we constructed a series of alpha-synuclein-enhanced green fluorescent protein (alpha-synucleinEGFP, SynEGFP) fusion proteins to address whether the Parkinson's disease-associated mutations alter the subcellular distribution of alpha-synuclein, and to use as a tool for experimental manipulations to induce aggregate formation. When transfected into mouse cultured primary neurons, the 49-kDa alpha-synucleinEGFP fusion proteins are partially truncated to a approximately 27-kDa form. This non-fluorescent carboxy-terminally modified fusion protein spontaneously forms inclusions in the neuronal cytoplasm. A marked increase in the accumulation of inclusions is detected following treatment with each of three proteasome inhibitors, n-acetyl-leu-leu-norleucinal, lactacystin and MG132. Interestingly, Ala30Pro alpha-synucleinEGFP does not form the cytoplasmic inclusions that are characteristic of wild-type and Ala53Thr alpha-synucleinEGFP, supporting the idea that the Ala30Pro alpha-synuclein protein conformation differs from wild-type alpha-synuclein. Similar inclusions are formed if alpha-synuclein carboxy-terminus is modified by the addition of a V5/6xHistidine epitope tag. By contrast, overexpression of unmodified alpha-synuclein does not lead to aggregate formation. Furthermore, synphilin-1, an alpha-synuclein interacting protein also found in Lewy bodies, colocalizes with the carboxy-terminally truncated alpha-synuclein fusion protein in discrete cytoplasmic inclusions.Our finding that manipulations of the carboxy-terminus of alpha-synuclein lead to inclusion formation may provide a model for studies of the pathogenic mechanisms of alpha-synuclein aggregation in Lewy bodies. 
 Question: Which is the primary protein component of Lewy bodies?
Output: alpha-synuclein
Context: After their season-opening loss to the Chargers, the Bears rebounded by winning their home opener against the Kansas City Chiefs. Bernard Berrian fumbled on the team's opening drive, but a staunch defensive effort held the Chiefs at bay, and eventually allowed the Bears to engineer a successful drive. John St. Clair, a reserve offensive tackle, scored the Bears' first offensive touchdown of the season from a one-yard pass from Rex Grossman. The team forced the Chiefs to punt on their next drive, which was returned for a touchdown by Devin Hester.The Chiefs scored their first points of the game after Damon Huard threw a sixteen-yard touchdown pass to Dwayne Bowe. During halftime, the Bears received the Pro Team Community Award for their charity efforts. The Bears' defense held the Chiefs to only three more points, after forcing pivotal turnovers in two red zone situations and also a blocked field goal attempt. Pro Bowlers Brian Urlacher, Lance Briggs, and Tommie Harris each recorded sacks, and forced Larry Johnson and Huard to leave the game with injuries. Cedric Benson recorded his first one hundred-yard rushing game. With 20-10 win, the Bears advanced to 1-1 record. Q2 - CHI - 10:29 - 2-yard TD pass from Rex Grossman to John St. Clair (Robbie Gould kick) (CHI 7-0) Q2 - CHI - 9:33 - Devin Hester 73-yard punt return TD (Gould kick) (CHI 14-0) Q2 - CHI - 2:30 - Robbie Gould 47-yard FG (CHI 17-0) Q2 - KC - 1:24 - 16-yard TD pass from Damon Huard to Dwayne Bowe (Dave Rayner kick) (CHI 17-7) Q3 - CHI - 8:36 - Robbie Gould 38-yard FG (CHI 20-7) Q3 - KC - 3:12 - Dave Rayner 45-yard FG (CHI 20-10) 
 Question: What was the longest field goal?
Output: 47-yard
Context: We offer five kinds of courses. Each course has been designed to help students according to their needs. Course 1: General English General English is designed to develop students' basic communication skills in: Speaking and Pronunciation, Reading, Listening, Writing, Grammar and Vocabulary. Tuesday to Friday: 9:00 am to 11:00 am, $288 per week. Course 2: Academic English Academic English is for students who want to take the IELTS exam or for those who need to use English in a professional area. Monday to Friday: 4:00 pm to 5:00 pm, $320 per week. Course 3: High School ESL Why not make the most of your time studying in Australia with the help from TIES? We have High School ESL classes each week specifically designed for International Students. Tuesday to Friday: 8:00 am to 11:00 am, $25 per hour. Course 4: Night Classes Do you want to improve your English and get the best results possible in your GRE test? We have two night classes each week designed to meet your needs. Tuesday and Thursday evenings: 8:30 pm to 10:30 pm, $60 per day. Course 5: One on One If you are interested in some One on One lessons with TIES teachers, we can design a curriculum to meet your needs. One on One lessons can improve your English language skills more quickly and help students who want to take TOEFL. Tuesday to Friday: 2:00 pm to 5:00 pm, $80 per hour. 
 Question: Which course would be helpful for students who want to take the IELTS exam?
Output: course 2.
Context: Sofia Boutella (born April 3, 1982) is an Algerian-French dancer, actress and musician, known mainly for hip-hop and street dance, and from the Nike Women advertising campaigns. 
 Question: What is the language of Sofia Boutella?
Output: french
Context: Hoping to rebound from a tough loss to the Patriots, the Bills would play their Week 2 home opener in an interconference duel with the Tampa Bay Buccaneers. This would be the first time that Buffalo ever hosted Tampa Bay in a regular season game, having played a preseason game with each other in 1977. In the first quarter, the Bills came out firing as quarterback Trent Edwards completed a 32-yard touchdown pass to wide receiver Lee Evans, safety Donte Whitner returning an interception 76 yards for a touchdown and kicker Rian Lindell making a 31-yard field goal. The Buccaneers would get on the board in the second quarter as quarterback Byron Leftwich completed a 42-yard touchdown pass to tight end Kellen Winslow, while Buffalo replied with Lindell getting a 43-yard field goal. Tampa Bay would close out the half as Leftwich completed an 8-yard touchdown pass to running back Carnell "Cadillac" Williams. After a scoreless third quarter, the Bills began to pull away as Lindell got a 43-yard field goal and Edwards completed a 43-yard touchdown pass to wide receiver Terrell Owens. The Buccaneers tried to rally as Leftwich completed a 6-yard touchdown pass to tight end Jerramy Stevens (with a failed two-point conversion), yet Buffalo closed out the game with Lindell nailing a 20-yard field goal. With the win, the Bills improved to 1-1. 
 Question: What team hosted this game?
Output: bills
Context: The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila by isolating nascent RNA from adult fly heads and subjecting samples to high throughput sequencing. There are a large number of edited sites within nascent exons. Nascent RNA from an ADAR-null strain was also sequenced, indicating that almost all A-to-I events require ADAR. Moreover, mRNA editing levels correlate with editing levels within the cognate nascent RNA sequence, indicating that the extent of editing is set cotranscriptionally. Surprisingly, the nascent data also identify an excess of intronic over exonic editing sites. These intronic sites occur preferentially within introns that are poorly spliced cotranscriptionally, suggesting a link between editing and splicing. We conclude that ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally. 
 Question: Which is the major RNA editing enzyme in Drosophila melanogaster?
Output: adar
Context: The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila by isolating nascent RNA from adult fly heads and subjecting samples to high throughput sequencing. There are a large number of edited sites within nascent exons. Nascent RNA from an ADAR-null strain was also sequenced, indicating that almost all A-to-I events require ADAR. Moreover, mRNA editing levels correlate with editing levels within the cognate nascent RNA sequence, indicating that the extent of editing is set cotranscriptionally. Surprisingly, the nascent data also identify an excess of intronic over exonic editing sites. These intronic sites occur preferentially within introns that are poorly spliced cotranscriptionally, suggesting a link between editing and splicing. We conclude that ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally. 
 Question: Which is the major RNA editing enzyme in Drosophila melanogaster?
Output: adenosine deaminase, rna-specific
Context: Edificio La Nacional is an Art Deco office building located in Avenida Juarez, in the Historical Centre of Mexico City, just across the street from Palacio de Bellas Artes.The building's architect was Manuel Ortiz Monasterio. 
 Question: Which is the kind of art style of Edificio La Nacional?
Output: art deco
Context: Parkinson's disease (PD) and related Lewy body diseases are characterized by deposition of -synuclein aggregates in both the central nervous system and peripheral nervous system. Synucleinopathy lesions spread to larger brain areas as the disease progresses, and prion-like cell-to-cell transmission of aggregated -synuclein is thought to be the underlying mechanism for this pathological spreading. LRRK2 is another protein linked to the pathogenesis of PD, and its presence in Lewy bodies has attracted much attention as to whether LRRK2 and -synuclein interplay during the pathogenesis of PD. However, the relationship between these two crucial proteins still remains unclear. In this review article, we will discuss the current state of knowledge in terms of how these proteins cause the disease and provide the hypothetical mechanisms by which LRRK2 might modify the generation and progression of synucleinopathy. 
 Question: Which disease of the central nervous system is characterized by the presence of Lewy bodies?
Output: parkinson's disease (pd)
Context: The Varsity Club was a professional wrestling heel stable in the NWA's Jim Crockett Promotions and World Championship Wrestling. 
 Question: Which industry is The Varsity Club associated with?
Output: professional wrestling
Context: Wars of America is a ''colossal'' bronze sculpture by Gutzon Borglum containing ''forty-two humans and two horses'', located in Military Park, Newark, Essex County, New Jersey, United States. 
 Question: What material was used for Wars of America?
Output: bronze
Context: The fourteenth week of the season featured a game between 5-7 teams as the Washington Redskins visited Soldier Field. In 48 games, the Redskins led the series 24-23-1 and had won the last five meetings. The Chicago offense took on a Washington defense that excelled against passers, being ranked tenth in the category; Dashon Goldson led all defensive backs in tackles with 95, while Bashaud Breeland led the team in passes defended with 13. The Redskins defensive rush, which had 20 sacks in 2015, was led by Ryan Kerrigan, who has 6.5. Despite such performances, the Redskins rush defense was ranked 29th in yards per carry with 4.64 and 25th in average rushing yards at 124.2. Jeff Joniak writes that the Bears could exploit this with the three-man rushing attack of Matt Forte, Jeremy Langford, and Ka'Deem Carey. On defense, the Bears faced a Kirk Cousins-led offense that focuses on quick passes; Cousins completed a league-high 68.6 percent of his passes, with 7.1 yards per pass. One of Cousins' main targets was tight end Jordan Reed, who scored six touchdowns and led the Redskins in yards after the catch. Rankings-wise, the pass attack was ranked 17th in the league in passing yards per game and 16th for yards per play. Joniak states that the Bears had to force turnovers, and an area was on third down, as five of Cousins' interceptions had been on third down. The Bears won the coin toss and elected to defer. Washington recorded a 15-play, 80-yard drive en route to scoring on Alfred Morris' one-yard touchdown run. After the Bears punted, the Redskins scored again with Cousins' fake read option leading to a three-yard touchdown run in the second quarter. Chicago's woes continued when the offense began the next drive on their own seven-yard line, and despite reaching the Washington 49, Jay Cutler was strip-sacked by Trent Murphy, who recovered the fumble. The Redskins failed to capitalize on the turnover and punted; the following two drives also ended with punts. With 52 seconds left in the first half, the Bears took over at their own 42, and managed to score with 18 seconds left when Cutler threw a 20-yard touchdown pass to Alshon Jeffery. Cousins kneeled once to end the half. After the Bears punted on the first drive of the second half, Cousins threw a five-yard touchdown pass to Reed. The Bears responded with Cutler's nine-yard touchdown pass to Zach Miller, who managed to escape DeAngelo Hall and made contact with Goldson as he reached the endzone. The score was the Bears' first third quarter touchdown of 2015. Afterwards, Cousins' pass for Pierre Garcon was intercepted by Kyle Fuller, and the Bears took advantage with Forte's seven-yard touchdown run to tie the score. Dustin Hopkins gave the Redskins the 24-21 lead on the first drive of the final quarter with a 47-yard field goal. Five drives later, the Bears attempted a 50-yard field goal with 1:40 left in the game. However, Robbie Gould's kick sailed wide left, and the Redskins ran the ball three times to end the game. 
 Question: Which player had the longest touchdown in the third quarter?
Output: zach miller
Context: As of the census of 2000, there were 445,342 people, 169,162 households, and 114,015 families residing in the county. The population density was 615 people per square mile (238/km). There were 178,913 housing units at an average density of 247 per square mile (95/km). The racial makeup of the county was 82.19% Race (United States Census), 1.15% Race (United States Census) or Race (United States Census), 0.65% Race (United States Census), 6.68% Race (United States Census), 0.30% Race (United States Census), 5.86% from Race (United States Census), and 3.17% from two or more races. 11.17% of the population were Race (United States Census) or Race (United States Census) of any race. 17.2% were of German American, 9.9% English American, 8.2% Irish American, and 6.7% Americans ancestry. 81.7% spoke only English at home, while 9.6% spoke Spanish and 1.2% Vietnamese. 
 Question: Which group from the census in the county is smaller: German American or English American?
Output: english american
Context: Vera Grafin von Lehndorff-Steinort or Veruschka von Lehndorff (born 14 May 1939) is a German model, actress, and artist who was popular during the 1960s. 
 Question: The nationality of Veruschka von Lehndorff?
Output: german
Context: Everyone can reduce their use of energy resources and the pollution the resources cause by conserving energy. Conservation means saving resources by using them more efficiently, using less of them, or not using them at all. You can read below about some of the ways you can conserve energy on the road and in the home. Much of the energy used in the U.S. is used for transportation. You can conserve transportation energy in several ways. For example, you can: plan ahead to avoid unnecessary trips. take public transit such as subways (see Figure 1.1) instead of driving. drive an energy-efficient vehicle when driving is the only way to get there. Q: What are some other ways you could save energy in transportation? A: You could carpool to save transportation energy. Even if you carpool with just one other person, thats one less vehicle on the road. For short trips, you could ride a bike or walk to you destination. The extra exercise is another benefit of using your own muscle power to get where you need to go. Many people waste energy at home, so a lot of energy can be saved there as well. What can you do to conserve energy? You can: turn off lights and unplug appliances and other electrical devices when not in use. use energy-efficient light bulbs and appliances. turn the thermostat down in winter and up in summer. Q: How can you tell which light bulbs and appliances use less energy? 
 Question: in 2004, the united states used most of its energy on ________________.
Output: transportation
Context: Flora Graeca was a publication of the plants of Greece in the late 18th century, resulting from a survey by John Sibthorp and Ferdinand Bauer. 
 Question: Who is the illustrator of Flora Graeca?
Output: ferdinand bauer
Context: Jon Krakauer, aside from the detailed recounting of the climb of the mountain in his book Eiger Dreams, mentions it briefly in Into Thin Air as one of his earlier difficult ascents (1992): ''I'd scaled a frightening, mile-high spike of vertical and overhanging granite called Cerro Torre; buffeted by hundred-knot winds, plastered with frangible atmospheric rime, it was once (though no longer) thought to be the world's hardest mountain''. 
 Question: What material was used for Cerro Torre?
Output: granite
Context: Precursor cells have been shown to be affected by oxidative stress, in vivo and vitro, but little is known about the expression of antioxidant mechanisms in neuronal/glial differentiation. We have characterized the expression of Cu/Zn superoxide dismutase (Cu/Zn SOD), one of the main antioxidant proteins involved in the breakdown of superoxide, in the immature rat dorsolateral subventricular zone (SVZ), rostral migratory stream (RMS) and hippocampal subgranular zone (SGZ). Progenitor cells were identified immunohistochemically on cryostat sections by 5'Bromodeoxyuridine (BrdU) incorporation and expressing cells were further characterized using double labeling for progenitor markers. In the SVZ, only a subpopulation of BrdU+ cells, mostly found in the medial SVZ, expressed Cu/Zn SOD. These cells were mostly nestin+ and some were also vimentin+. In contrast, in the lateral SVZ few Cu/Zn SOD+/BrdU+ cells were found. These were primarily nestin+, vimentin-, showed some PSA-NCAM expression, but only a few were NG2+. In the RMS and SGZ virtually all BrdU+ progenitors were Cu/Zn SOD+ and expressed nestin and vimentin. Some RMS cells were also PSA-NCAM+. These findings show a heterogeneous expression of Cu/Zn SOD in restricted cell types in the germinative zones and suggest a role for antioxidant Cu/Zn SOD in progenitor cells of the immature rat brain. 
 Question: Which intermediate filament (IF) protein can be used as a non-specific marker of the neuronal precursor cells of the subventricular zone?
Output: nestin
Context: Environmental activists in South Korea are condemning a government plan to hunt endangered whales for scientific research. They believe the plan is part of an effort to restart commercial whaling activities. Such activities are banned in many countries. South Korea announced the proposal in July at a meeting of the International Whaling Commission in Panama. The head of the South Korean delegation said the plan was needed to answer questions about minke whale populations. He said the hunt would take place near the South Korean coast. But he did not say how many of the animals would be caught. The International Whaling Commission has yet to make a decision on the South Korean plan. The organization banned commercial whaling in 1986 because of concerns about the survival of whale species. But now, some South Korean fishermen say they are facing a threat from minke whales. They say these animals are eating what would have been their catch. The plan was immediately condemned by anti-whaling nations. Wildlife activists also criticized the proposal. Han Jeong-hee works in Seoul for the environmental group Greenpeace."It's really regretful to hear that the South Korean government is, like, considering conducting scientific whaling. Scientific whaling is just, like, thinly disguised commercial whaling. And, you know, we are of course against all commercial whaling. Japan's the only country that is doing scientific whaling at the moment and South Korea is just trying to follow that." Apart from the plan in South Korea, an aquarium in the American state of Georgia also wants to import eighteen beluga whales from Russia. The United States currently has 31 beluga whales. They are living in six aquariums and marine parks. Four of them are at the Georgia Aquarium in Atlanta. The Georgia Aquarium has asked the National Oceanic and Atmospheric Administration (NOAA) for permission to import the beluga whales. If it was approved, aquarium officials would send some of the animals to the other facilities. The Georgia Aquarium says it hopes to use the beluga whales in research, education and breeding programs. They currently are being held at a Russian research center. Yet many people oppose the plan. They say it is wrong to catch any wild animal. NOAA officials are studying how the beluga whales might be affected by being brought to the United States. They also want to know whether the Georgia Aquarium and its partners can properly care for the whales and how they might be used in educational activities. The federal Marine Mammal Protection Act sets rules which NOAA must consider when deciding whether these animals may be imported. NOAA officials told VOA they plan to make a decision on the request by early next year. 
 Question: In which country is whale hunting permitted at the moment?
Output: japan.
Context: Giant-cell tumor of bone is a rare, locally aggressive tumor that typically occurs in the bones of skeletally mature young adults in their second to fourth decades. Traditionally, surgery has been the mainstay of therapy for this disease, but the disease can recur even with optimal procedures. Furthermore, it may occur in locations where a surgical approach would be morbid. The maturation of the understanding of the role of the receptor activator of nuclear factor-B ligand (RANKL) in the pathophysiology of giant-cell tumor of bone has led to the use of denosumab, a monoclonal antibody against RANKL, in this disease. In 2013, the US Food and Drug Administration approved denosumab for use in patients with recurrent/unresectable/metastatic giant-cell tumor of bone or for patients in whom surgery would be morbid. 
 Question: Which is the target of the drug Denosumab?
Output: rankl
Context: Giant-cell tumor of bone is a rare, locally aggressive tumor that typically occurs in the bones of skeletally mature young adults in their second to fourth decades. Traditionally, surgery has been the mainstay of therapy for this disease, but the disease can recur even with optimal procedures. Furthermore, it may occur in locations where a surgical approach would be morbid. The maturation of the understanding of the role of the receptor activator of nuclear factor-B ligand (RANKL) in the pathophysiology of giant-cell tumor of bone has led to the use of denosumab, a monoclonal antibody against RANKL, in this disease. In 2013, the US Food and Drug Administration approved denosumab for use in patients with recurrent/unresectable/metastatic giant-cell tumor of bone or for patients in whom surgery would be morbid. 
 Question: Which is the target of the drug Denosumab?
Output: receptor activator of nuclear factor-κb ligand
Context: The Morupule Colliery is a coal mine located in Palapye, Botswana, and owned and operated by Debswana, a partnership between the government of Botswana and De Beers. 
 Question: The product of Morupule Colliery is what?
Output: coal
Context: It is unanimously accepted that there is an unmet need for pain medications that are both effective and safe. Unfortunately, no really novel analgesics have been approved over the past three decades. In view of both experimental and clinical evidence of a major role for nerve growth factor (NGF) in the generation and maintenance of a wide range of pain states, drug discovery efforts focusing on the development of anti-NGF agents have aroused particular interest. Several humanized anti-NGF monoclonal antibodies (mAbs) have entered clinical trials as potential analgesics. In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for pain, reviewing the analgesic efficacy and safety of anti-NGF agents based on data from fully published studies, conference abstracts, and the US Food and Drug Administration (FDA) website, and discussing the possible future of these agents in managing chronic pain. Anti-NGF mAbs produced significant pain relief and functional improvement in patients with osteoarthritis of the knee and/or hip. Conversely, studies in non-specific lower back pain generated mixed results; overall, this condition appeared to be less responsive to anti-NGF agents than osteoarthritis. Finally, there was no conclusive evidence of the effectiveness of anti-NGF mAbs in some types of chronic visceral or neuropathic pain. Furthermore, these studies raised safety concerns about anti-NGF mAbs. As a class, these drugs may cause or worsen peripheral neuropathies. But the most problematic issue-which prompted the FDA to place studies of these compounds on clinical hold in 2010-was rapid joint destruction leading to joint replacement surgery. The aetiologies of these side effects have been much debated and their pathophysiology is poorly understood. After an Arthritis Advisory Committee meeting held in March 2012, pharmaceutical companies negotiated with the FDA on the conditions for restarting clinical studies. Although the FDA lifted its clinical hold, there remain many unresolved issues about the long-term efficacy and safety of anti-NGF mAbs. While acknowledging that the future of these drugs is unforeseeable, it appears that they may not be the safe and effective painkillers that have been awaited for decades. 
 Question: What is the target of tanezumab?
Output: ngf
Context: It is unanimously accepted that there is an unmet need for pain medications that are both effective and safe. Unfortunately, no really novel analgesics have been approved over the past three decades. In view of both experimental and clinical evidence of a major role for nerve growth factor (NGF) in the generation and maintenance of a wide range of pain states, drug discovery efforts focusing on the development of anti-NGF agents have aroused particular interest. Several humanized anti-NGF monoclonal antibodies (mAbs) have entered clinical trials as potential analgesics. In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for pain, reviewing the analgesic efficacy and safety of anti-NGF agents based on data from fully published studies, conference abstracts, and the US Food and Drug Administration (FDA) website, and discussing the possible future of these agents in managing chronic pain. Anti-NGF mAbs produced significant pain relief and functional improvement in patients with osteoarthritis of the knee and/or hip. Conversely, studies in non-specific lower back pain generated mixed results; overall, this condition appeared to be less responsive to anti-NGF agents than osteoarthritis. Finally, there was no conclusive evidence of the effectiveness of anti-NGF mAbs in some types of chronic visceral or neuropathic pain. Furthermore, these studies raised safety concerns about anti-NGF mAbs. As a class, these drugs may cause or worsen peripheral neuropathies. But the most problematic issue-which prompted the FDA to place studies of these compounds on clinical hold in 2010-was rapid joint destruction leading to joint replacement surgery. The aetiologies of these side effects have been much debated and their pathophysiology is poorly understood. After an Arthritis Advisory Committee meeting held in March 2012, pharmaceutical companies negotiated with the FDA on the conditions for restarting clinical studies. Although the FDA lifted its clinical hold, there remain many unresolved issues about the long-term efficacy and safety of anti-NGF mAbs. While acknowledging that the future of these drugs is unforeseeable, it appears that they may not be the safe and effective painkillers that have been awaited for decades. 
 Question: What is the target of tanezumab?
Output: nerve growth factor
Context: The Beginning of the Civil Rights Movement In 1955,bus seats for African Americans and whites were separated in parts of the U.S.. On December 1,1955,in the city of Montgomery,Alabama,a conflict,or disagreement,started when an African American woman named Rosa Parks refused to give her bus seat to a white man and go to the back of the bus. The police took 42yearold Parks to jail. The African American community was extremely angry. They had a meeting and decided to work together to protest discrimination. They agreed to boycott the buses on the day that Parks went to court. The day was a success. Empty buses drove through the streets. The city lost money. The community decided to continue the boycott. They elected a man named Martin Luther King,Jr. to be the leader. The boycott continued. It was difficult for African Americans to get to work without buses,but they didn't stop the boycott. The city continued to lose money. Finally,the U.S. Supreme Court decided that Montgomery's bus laws were unfair and gave the African American community equal right. On December 21,1956,the bus boycott ended. The Montgomery Bus Boycott was the beginning of the Civil Rights Movement. The movement eventually led to the Civil Rights Act in 1964,a set of laws that made discrimination a crime. During the Montgomery Bus Boycott,people worked together to change the government. Today,people in the U.S. continue to work together for a change. Now hundreds of organizations and community groups work to protect the rights of U.S. citizens and residents. 
 Question: What is the final result of the Civil Rights Movement?
Output: the movement eventually led to the civil rights act in 1964,a set of laws that made discrimination a crime.
Context: ''Anymore'' is a song co-written and recorded by American country music artist Travis Tritt. 
 Question: Who sang or played Anymore?
Output: travis tritt
Context: The vitamin K antagonists (VKAs) have been the standard (and only) oral anticoagulants used for the long-term treatment or prevention of venous thromboembolism or stroke in patients with atrial fibrillation. The coagulopathy induced by VKAs can be reversed with vitamin K, and in urgent situations, the vitamin K-dependent coagulation factors can be replaced by transfusion. In the last decade, a new class of oral anticoagulants has been developed, direct oral anticoagulants that bind to a specific coagulation factor and neutralize it. These compounds were shown to be effective and safe compared with the VKAs and were licensed for specific indications, but without a specific reversal agent. The absence of a reversal agent is a barrier to more widespread use of these agents. Currently, for the management of major life-threatening bleeding with the direct oral anticoagulants, most authorities recommend the use of four factor prothrombin complex concentrates. There are now three reversal agents in development and poised to enter the market. Idarucizumab is a specific antidote targeted to reverse the direct thrombin inhibitor, dabigatran, which was recently approved for use in the USA. Andexanet alfa is an antidote targeted to reverse the oral direct factor Xa inhibitors as well as the indirect inhibitor enoxaparin. Ciraparantag is an antidote targeted to reverse the direct thrombin and factor Xa inhibitors as well as the indirect inhibitor enoxaparin. 
 Question: Which drug can be reversed with idarucizumab?
Output: dabigatran
Context: In late July, Danzig was re-inforced by a Dutch garrison, and a combined Danish and Dutch fleet broke the naval blockage imposed on Danzig by Charles X Gustav. On 28-30 July, a combined Brandenburgian-Swedish army was able to defeat the Polish-Lithuanian army in the Battle of Warsaw, forcing John II Casimir to retreat to Lublin. In August, Alexis' army took Livonian Kokenhausen , laid siege to Riga and Dorpat and raided Estonia, Ingria and Kexholm. On 4 October, John II Casimir stormed eczyca in Greater Poland before heading for Royal Prussia, and on 8 October, Wincenty Korwin Gosiewski with 12,000 to 13,000 Lithuanian and Crimean Tartar cavalry overran a Brandenburgian-Swedish force in the Battle of Prostken in Ducal Prussia. Gosiewski then ravaged Ducal Prussia, burning 13 towns and 250 villages, in a campaign that entered folklore because of the high death toll and the high number of captives deported to the Crimea. On 22 October, Gosiewski was defeated by Swedish forces in the Battle of Filipow and turned to Lithuania. Also on 22 October, besieged Dorpat surrendered to Alexis, while the Russian siege of Swedish-held Riga was lifted. John II Casimir meanwhile took Bromberg and Konitz in Royal Prussia, and from 15 November 1656 until February 1657 stayed in Danzig, where a Swedish siege had to be lifted due to Dutch intervention, just 55 kilometers away from Charles X Gustav's quarters in Elbing. 
 Question: What happened second: Battle of Warsaw or Casimir stormed eczyca?
Output: casimir stormed łęczyca
Context: The Ehlers-Danlos syndrome (EDS) comprises a group of hereditary connective tissue disorders. Periventricular nodular heterotopia (PNH) is a human neuronal migration disorder characterised by seizures and conglomerates of neural cells around the lateral ventricles of the brain, caused by FLNA mutations. FLNA encodes filamin A, an actin binding protein involved in cytoskeletal organisation. The amino-terminal actin binding domain (ABD) of filamins contains two tandem calponin homology domains, CHD1 and CHD2. To report clinical and genetic analyses in a Spanish family affected by a connective tissue disorder suggestive of EDS type III and PNH. A clinical and molecular study was undertaken in the three affected women. Clinical histories, physical and neurological examinations, brain magnetic resonance imaging studies, and skin biopsies were done. Genetic analysis of the FLNA gene was undertaken by direct sequencing and restriction fragment length polymorphism analysis. Mutation analysis of the FLNA gene resulted in the identification of a novel mutation in exon 3 (c.383C-->T) segregating with the combination of both syndromes. This mutation results in a substitution of an alanine residue (A128V) in CHD1. The findings suggest that the Ala128Val mutation causes the dual EDS-PNH phenotype. This association constitutes a new variant within the EDS spectrum. This is the first description of a familial EDS-PNH association with a mutation in FLNA. 
 Question: What tissue is most affected in Ehlers-Danlos syndromes?
Output: connective tissue
Context: Wafika Sultan Al-Essa (Arabic: ; born 1952 in Bahrain) is a Qatari artist specializing in painting and plastic arts. 
 Question: When is the date of birth of Wafika Sultan Al-Essa?
Output: 1952
Context: The Alexandria Museum of Art (AMoA) of Alexandria, central Louisiana, USA opened its doors in 1977 in the historic Rapides Bank Building (circa 1898). 
 Question: When was Alexandria Museum of Art opened officially?
Output: 1977
Context: Weisse Wiese (The White Field), also known as Borussia Sportpark, was the first home stadium of Borussia Dortmund. 
 Question: What team uses Weisse Wiese?
Output: borussia dortmund
Context: The film starts on June 16, 1994 with Jesse meeting Celine on a train from Budapest and striking up a conversation with her. Jesse is going to Vienna to catch a flight back to the United States, whereas Celine is returning to university in Paris after visiting her grandmother. When they reach Vienna, Jesse convinces Celine to disembark with him, saying that 10 or 20 years down the road, she might not be happy with her marriage and might wonder how her life would have been different if she had picked another guy, and this is a chance to realize that he himself is not that different from the rest; in his words, he is "the same boring, unmotivated guy." Jesse has to catch a flight early in the morning and does not have enough money to rent a room for the night, so they decide to roam around in Vienna. After visiting a few landmarks in Vienna, they share a kiss at the top of the Wiener Riesenrad at sunset and start to feel a romantic connection. As they continue to roam around the city, they begin to talk more openly with each other, with conversations ranging from topics about love, life, religion, and their observations of the city. Celine tells Jesse that her last boyfriend broke up with her six months ago, claiming that she "loved him too much". When questioned, Jesse reveals he had initially come to Europe to spend time with his girlfriend who was studying in Madrid, but they had broken up when she was avoiding him while he was there. He decided to take a cheap flight home, via Vienna, but it did not leave for two weeks so he bought a Eurail pass and traveled around Europe. When they are walking alongside the Donaukanal (Danube canal) they are approached by a man who, instead of begging, offers to write them a poem with a word of their choice in it. Jesse and Celine decide on the word "milkshake", and are soon presented with the poem Delusion Angel (written for the film by the poet David Jewell). In a traditional Viennese cafe, Jesse and Celine stage fake phone conversations with each other, playing each other's friends they pretend to call. Celine reveals that she was ready to get off the train with Jesse before he convinced her. Jesse reveals that after he broke up with his girlfriend, he bought a flight that really was not much cheaper, and all he really wanted was an escape from his life. They admit their attraction to each other and how the night has made them feel, though they understand that they probably will not see each other again when they leave. They simply decide to make the best of what time they have left, ending the night with the implication of a sexual encounter between them. At that point, Jesse explains that if given the choice, he would marry her instead of never seeing her again. The film ends the next day at the train station, where, just as Celine's train is about to leave, the couple decides not to exchange any contact information but instead to meet at the same place in six months. 
 Question: Where do Jesse and Cline first kiss?
Output: at the top of the wiener riesenrad
Context: Bruce Gradkowski came into the game as Oakland's starter at Quarterback, trying to cap on his gamewinning performance last week vs. St. Louis Arizona started the game with a 102-yard kickoff return from LaRod Stephens-Howling. The Raiders answered quickly though when Gradkowski completed a 22-yard pass to tight-end Zach Miller. This was followed by three field goals, two for Oakland, one for Arizona, and Oakland led 13-10 at the end of the first quarter. Both Gradkowski and Derek Anderson then traded touchdowns and the Raiders led 20-17 at the half. Anderson helped Arizona take the lead late in the third quarter with an 8-yard touchdown pass to Larry Fitzgerald. Arizona led 24-20 at the end of the third quarter. Sebastian Janikowski made the lead 24-23 with another field goal in the fourth quarter. Arizona held on for the win after Janikowski missed a 32-yard field goal as time expired. Both the Raiders and Cardinals committed numerous mistakes, including two muffed punts by Arizona. Oakland committed 11 penalties for 123yards, Arizona seven for 104. 
 Question: What was the score after the 2nd quarter ended?
Output: 20-17
Context: In the county, the population was spread out with 23.20% under the age of 18, 7.70% from 18 to 24, 27.00% from 25 to 44, 28.00% from 45 to 64, and 14.10% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 97.00 males. For every 100 females age 18 and over, there were 96.40 males. 
 Question: Which age group is smaller: 25 to 44 or 45 to 64?
Output: 25 to 44
Context: Microsoft has a problem:It desperately wants the remaining Windows XP users to upgrade to a newer version of the operating system but a good many of them still haven't started.The latest numbers from NetMarket show that Windows XP still accounts for around 29.5%of all desktops in use even though Microsoft is due to end support for the l3-Year-old platform on April 8th.ZDNet reports that Microsoft plans to force remaining XP users to start next week by sending them notices reminding them again that it will end XP support within a month. However, as Computerworld reports,Microsoft may have a tough time convincing some Windows XP users to upgrade because it's trying to sell them on Windows 8,the newest operating system that has angered many longtime PC users by removing the traditional Start menu and by adding the interface a special feature.Computerworld writes that many Windows users expressed anger last month when Microsoft asked them to help switch as many people as they could from Windows XP to Windows 8 partly because Microsoft hasn't offered any sort of discount for Windows XP users making the switch. This is particularly tiresome, these users said,because switching from XP to Windows 8 won't just require a software upgrade but will instead likely force them to buy new machines capable of running Microsoft's new operating system.Some users were also annoyed that Microsoft only mentioned Windows 8 and not Windows 7 as upgrade possibilities. In the end,it looks like when Microsoft ends support for Windows XP next month there will still be a large part of the desktop PC world using the platform.Hackers who have been saving up all their best new malware for the day when Windows XP support ends are about to have a field day. 
 Question: How will Microsoft remind users ofthe stop of XP support?
Output: by sending them notices.
Context: However, the Seven Years' War ended on February 10, 1763 with the signing of the Treaty of Paris in Paris, France. Also, Silang was assassinated on May 28, 1763 by an Indio under the employ of the friars. The Spanish were then able to focus on the uprising and mustered forces to surround Palaris. The Spanish friars, who were allowed to stay in the province, also started a campaign to persuade Pangasinan residents of the futility of the Palaris Revolt. By September 1763, news of the peace treaty reached Pangasinan and army of Palaris' men surrendered and returned to normal life amid the Spanish offensive. Palaris tried to fend off the offensive at the village of Mabalitec near the Agno River between Binalatongan and Bayambang in December 1763. To prevent the Spanish from seeking lodging in his hometown, he ordered his men to raze Binalatongan. But the Spanish won the Battle of Mabalitec, demoralizing Palaris' forces. The town of Binalatongan was rebuilt in another site between December 1763 to June 1764 and renamed San Carlos , in honor of the reigning King Carlos III of Spain. Palaris' forces made a last stand at the town of San Jacinto, Pangasinan, but they were defeated. Palaris' advisers, Andres Lopez and Juan de Vera Oncantin, were captured. They would later be hanged. 
 Question: What were the men to Palaris that were hanged?
Output: palaris' advisers
Context: Flying Officer Raimund Sanders Draper, known as ''Smudge'', was an American volunteer World War II Royal Air Force (RAF) pilot of No. 64 Squadron. 
 Question: What is Raimund Sanders Draper's place of employment?
Output: royal air force
Context: Coming off their home win over the Lions, the 49ers flew to the Louisiana Superdome for a Week 4 duel with the New Orleans Saints. In the first quarter, the Niners struck first as kicker Joe Nedney got a 47-yard field goal. In the second quarter, the Saints took the lead with QB Drew Brees completing a 5-yard and a 33-yard TD pass to WR Lance Moore. San Francisco would answer with Nedney's 49-yard field goal, yet New Orleans replied with Brees' 47-yard TD pass to WR Robert Meachem. In the third quarter, the 49ers tried to rally as Nedney kicked a 38-yard field goal. However, in the fourth quarter, the Saints continued to pull away as RB Deuce McAllister got a 1-yard TD run. The Niners tried to rally as QB J.T. O'Sullivan completed a 5-yard TD pass to WR Isaac Bruce, yet New Orleans sealed the win with kicker Martin Gramatica nailing a 31-yard field goal. 
 Question: Which team failed to score any third quarter points?
Output: saints
Context: Hoping to rebound from their three-game losing streak, the Raiders flew to Dolphin Stadium for a Week 11 duel with the Miami Dolphins. In the first quarter, Oakland trailed early as Dolphins WR Ted Ginn, Jr. got a 40-yard TD run. In the second quarter, the Raiders responded with kicker Sebastian Janikowski getting a 21-yard field goal. In the third quarter, Oakland started to catch up as DE Jay Richardson sacked QB Chad Pennington in his own endzone for a safety. Miami would answer with RB Patrick Cobbs getting a 10-yard TD run. In the fourth quarter, the Raiders took the lead as Janikowski got a 37-yard field goal, along with WR Johnnie Lee Higgins returning a punt 93 yards for a touchdown. However, the Dolphins sealed Oakland's fate as kicker Dan Carpenter nailed a 38-yard field goal. 
 Question: Which team scored first?
Output: dolphins
Context: Hoping to rebound from a tough loss to the Patriots, the Bills would play their Week 2 home opener in an interconference duel with the Tampa Bay Buccaneers. This would be the first time that Buffalo ever hosted Tampa Bay in a regular season game, having played a preseason game with each other in 1977. In the first quarter, the Bills came out firing as quarterback Trent Edwards completed a 32-yard touchdown pass to wide receiver Lee Evans, safety Donte Whitner returning an interception 76 yards for a touchdown and kicker Rian Lindell making a 31-yard field goal. The Buccaneers would get on the board in the second quarter as quarterback Byron Leftwich completed a 42-yard touchdown pass to tight end Kellen Winslow, while Buffalo replied with Lindell getting a 43-yard field goal. Tampa Bay would close out the half as Leftwich completed an 8-yard touchdown pass to running back Carnell "Cadillac" Williams. After a scoreless third quarter, the Bills began to pull away as Lindell got a 43-yard field goal and Edwards completed a 43-yard touchdown pass to wide receiver Terrell Owens. The Buccaneers tried to rally as Leftwich completed a 6-yard touchdown pass to tight end Jerramy Stevens (with a failed two-point conversion), yet Buffalo closed out the game with Lindell nailing a 20-yard field goal. With the win, the Bills improved to 1-1. 
 Question: Who threw the longest touchdown pass?
Output: edwards