niryuu/sni-each-converted huggingface dataset:
Context: In week 12, the Lions flew east for another battle of division leaders, this time with the AFC East's 8-2 New England Patriots. The Lions failed to score a touchdown for the second consecutive week, and fell to second place after a blowout loss. The Lions scored first when Matt Prater hit a 48-yard field goal in the first quarter. The Patriots then took the lead which they kept for the rest of the game when Tim Wright caught a 4-yard touchdown pass from Tom Brady near the end of the first quarter. The Lions responded with a 20-yard field goal in the second quarter. The Patriots then scored two touchdowns on a 3-yard run from LeGarrette Blount, then an 8-yard catch by Tim Wright. New England's Stephen Gostkowski then kicked a 35-yard field goal to make the score 24-6 at halftime. The only score of the third quarter was a Patriots 35 yard field goal. In the final quarter, the Lions scored their third field goal, this one from 49 yards out. The Patriots capped their large victory with a 1-yard touchdown run from LeGarrette Blount. 
 Question: How far was Praters field goal in the first quarter?
Output: 48-yard
Context: Ehlers-Danlos syndrome is a complex hereditary connective tissue disorder that is characterized by abnormalities of the skin and joints and visceral and neurological manifestations. At present, at least 11 forms are recognized on the basis of their clinical characteristics, methods of transmission, and biochemical defect. The neurologic manifestations include cerebrovascular disease, peripheral neuropathy, plexopathy, periventricular subependymal heterotopias, and epilepsy. Previously, 2 females were reported to be affected with subependimal periventricular heterotopias and Ehlers-Danlos syndrome type 1. The authors report a new case of a 12-year-old girl with similar clinical and neuroradiological features. 
 Question: What tissue is most affected in Ehlers-Danlos syndromes?
Output: connective tissue
Context: Many mutations of the NF1 gene have been reported in patients with neurofibromatosis type 1 (NF1); however, there have been no documented NF1 gene mutations in Japanese NF1 patients. In the present study, we used the polymerase chain reaction (PCR) and DNA sequencing analysis to characterize the NF1 gene in a 53-year-old Japanese patient with NF1 who suffered from neurofibroma, pheochromocytoma, and gastrointestinal stromal tumor (GIST). Direct sequence analyses revealed a single base substitution in the splicing donor site of intron 6 (IVS6 888+1, G --> A) in one NF1 allele, resulting in an altered splice site (ss) in the mutated allele. Splicing at the cryptic 5' ss in the mutated allele generated mRNA with an insertion of 60 nucleotides. In addition, we screened for mutations in exons 9, 11, 13, and 17 of the c-kit gene in GIST and the succinate dehydrogenase subunit D (SDHD) gene in the pheochromocytoma, but we did not detect any somatic mutations. We report here the first case of an NF1 patient with four neoplasms: neurofibroma, pheochromocytoma, astrocytoma and GIST. Our results suggest that the molecular pathogenesis of GISTs in NF1 patients is different from that in non-NF1 patients. 
 Question: Which is the gene mutated in type 1 neurofibromatosis?
Output: nf1
Context: Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia chromosome, which is associated with a balanced translocation involving chromosomes 9 and 22 to produce a fusion gene (bcr-abl) that gives rise to a constitutively activated Abl tyrosine kinase. This kinase led to the discovery of several small-molecule inhibitors, imatinib being the first and most successful of these. Resistance to imatinib results in some patients from Abl kinase point mutations. Overcoming imatinib resistance represents one of the biggest challenges facing clinicians in the modern management of CML. In this review, we discuss the current understanding of CML pathophysiology and mechanisms of imatinib resistance and how advancing this knowledge has led to the design of novel therapies in the area of blastic phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia with previous imatinib failure. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Coming off their home win over the Rams, the Bengals flew to Bill Walsh Field at Monster Park for a Saturday night interconference duel with the San Francisco 49ers. After a scoreless first quarter, Cincinnati trailed early in the second quarter as 49ers QB Shaun Hill got a 3-yard TD run. Afterwards, the Bengals would take the lead as kicker Shayne Graham managed to get a 24-yard field goal, while QB Carson Palmer completed a 52-yard TD pass to WR Chris Henry. San Francisco would end the half with Hill completing a 17-yard TD pass to TE Vernon Davis. In the third quarter, the 49ers increased their lead with kicker Joe Nedney getting a 29-yard and a 38-yard field goal. In the fourth quarter, Cincinnati tried to respond as Graham kicked a 35-yard field goal. However, the 49ers' defense held on for the win. With the loss, the Bengals fell to 5-9, securing Head Coach Marvin Lewis' first losing season with Cincinnati. 
 Question: Who threw the longest pass?
Output: carson palmer
Context: Recently I overheard a father and daughter in their last moments together at the airport. The airline had announced her departure and standing near the security gate,they hugged and he said,"I love you. I wish you enough" She in turn said,"Dad,our life together has been more than enough. Your love is a11 I ever needed. I wish you enough,too,Dad. "They kissed and she left He walked over toward the window where I was seated Standing there I could see he wanted and needed to cry. I tried not to disturb his privacy, but he welcomed me in by asking,"Did you ever say good--bye to someone knowing it would be forever?'' "Yes,I have. "I replied"Forgive me for asking, but why is this a forever good-bye?""I'm old and she lives much too far away I have challenges ahead,and the reality is,the next trip back will be for my funeral. "He said. "When you were saying good-bye 1 heard you say,'1 wish you enough. 'm ay I ask what that means?" He began to smile. "That's a wish that has been handed down for many generations within my family. My parents used to say it to everyone. " He paused for a moment,looking up as if trying to remember it in detail,and then he smiled even more"When we said'I wish you enough',we were wanting the other person to have a life filled with just enough good things to sustain(...)them. ,,He continued and then turning toward me be shared the following: "I wish you enough sun to keep your attitude bright. I wish you enough rain to appreciate the sun more. I wish you enough happiness to keep your spirit alive. I wish you enough pain so that the smallest joys in life appear much bigger. I wish you enough gain to satisfy your wanting. I wish you enough loss to appreciate a11 that you possess I wish you enough 'Hellos' to get you enough the final 'Good--byes'" Then he walked away. I WISH YOU ENOUGH ! 
 Question: Which is probably the best title of this story?
Output: i wish you enough
Context: A person who is deaf when he is born is usually dumb as well. There may be nothing wrong with his mouth and tongue, but he cannot speak. This is because he cannot hear people, so he has nothing to imitate . He may try to make sounds himself, but cannot hear his own voice. However, even though he finds it difficult to speak and cannot hear, he can learn to read. Nowadays such persons can also be taught to speak because we have modern methods and equipment, but we did not have these when Helen Keller was born. Even with modern methods and equipment, however, it is not easy for deaf children to learn to speak, though most of them succeed. When a child is deaf and blind as well, it becomes much more difficult, though it is possible. Helen Keller was born in 1880. She became very ill at the age of nineteen months. Medical knowledge was not as great then as it is now. She did not die but lost her sight and hearing. As a result, she became dumb as well. Her parents did their best to teach her, but she couldn't speak by the age of six. Then, in 1887, a teacher, Miss Sullivan, came to live with her. Miss Sullivan herself had been blind. She had been partly cured. Though she could not see very well, she was not blind. Helen was a difficult pupil at first, but in a month Helen had learned how to understand signs and how to make them herself. At last in spite of her great difficulties, Helen learned to read, write and speak, even though she was deaf and blind. She even went to college and had full education. She wrote many books, and though other people have written books about her, her own books are the ones that best explain how it feels to be deaf, dumb and blind. Her best book is The Story of My Life. Perhaps you have read it. Though it was written in 1902, it is still a very interesting book. Even if you have not read it, you may have heard of Helen Keller. 
 Question: How long did it take Keller to understand signs?
Output: a month
Context: City Varieties The Headrow, Leeds.Tel.430808. Oct 10--11 only.A Night at the Varieties.All the fun of an old music hall with Barry Cryer, Duggle Brown, 6 dancers, Mystina, Jon Barker, Anne Dural and the Tony Harrison Trio; Laugh again at the old jokes and listen to your favorite songs. Performances: 8 pm nightly. Admission: L5; under 16 or over 60: L4. York Theatre Royal St Leonard's Place, York.Tel.223568. Sept 23--Oct 17 Groping for Words--a comedy by Sue Townsend.Best known for her Adrian Mole Diaries, Townsend now writes about an evening class, which two men and a woman attend.A gentle comedy. Admission: First night, Mon: L2; Tues--Fri: L3.25--5.50; Sat: L3.50--5.75. Halifax Playhouse King's Cross Street, Halifax.Tel.365998. Oct 10--17 On Golden Pond by Ernest Thompson.This is a magical comedy about real people.A beautifully produced, well-acted play for everyone.Don't miss it. Performances: 7:30 pm. Admission: L2.Mon: 2 seats for the price of one. Grand Theatre Oxford Street, Leeds.Tel.502116. Restaurant and Cafe. Oct--17 The Secret Diary of Adrian Mole, Aged 13.Sue Townsend's musical play, based on her best-selling book. Performances: Evenings 7:45.October 10--17, at 2:30 pm.No Monday performances. Admission: Tues--Thurs: L2--5; Fri & Sat: L2--6. 
 Question: Which theatre offers the cheapest seat?
Output: halifax playhouse.
Context: Neurofibromatosis type 1 (NF1) is one of the most common human genetic disorders and is associated with significant morbidity and mortality. The gene responsible for this disorder, NF1, encodes neurofibromin, which can function to down-regulate ras activity. Mutations that inactivate NF7 result in elevated levels of ras signaling and increased cell proliferation in some tissues. NF7 functions as a tumor suppressor gene; patients inherit one mutated copy and are believed to acquire a "second hit" in tissues that go on to form benign or malignant tumors. NF7 is expressed widely, yet certain tissues are more susceptible to growth dysregulation in NF1 patients. Cardiovascular defects also contribute to NF1, though the cause remains unclear. In a recent study, we used tissue-specific gene inactivation in mice to study the role of neurofibromin in heart development. A further understanding of neurofibromin function will help to elucidate the pathophysiology of NF1 and will also lead to a better understanding of cell cycle regulation and ras pathways in specific cell types. Finally, we comment on how similar genetic strategies can be used in mice to study the role of additional signaling pathways involved in heart development. 
 Question: Which is the gene mutated in type 1 neurofibromatosis?
Output: nf1
Context: Gustav Vasas intag i Stockholm 1523 (or Gustav Vasa enters Stockholm 1523) is a painting painted for the Nationalmuseum in Stockholm by the Swedish painter Carl Larsson. 
 Question: What is the name of the place where Gustav Vasas intag i Stockholm 1523 can be found?
Output: nationalmuseum
Context: According to Apollodorus, Agenor was born in Memphis of Egypt to Poseidon and Libya and he had a twin brother named Belus. 
 Question: What was the name of Agenor mother?
Output: libya
Context: The Battle of al-Qadisiyyah (Arabic: ; transliteration, Ma'rakatu al-Qadisiyyah; Persian: transliteration Nabard-e Qadesiyeh; alternative spellings: Qadisiyya, Qadisiyyah, Kadisiya, Ghadesiyeh), fought in 636, is said to be a decisive engagement between the Arab Muslim army and the Sassanid Persian army during the first period of Muslim expansion. 
 Question: On what date did Battle of al-Qadisiyyah end?
Output: 636
Context: To evaluate and compare outcomes for patients with vestibular schwannoma (VS) treated in a single institution with linac-based stereotactic radiosurgery (SRS) or by fractionated stereotactic radiotherapy (SRT). One hundred and nineteen patients (SRS = 78, SRT = 41) were treated. For both SRS and SRT, beam shaping is performed by a mini-multileaf collimator. For SRS, a median single dose of 12.5 Gy (range, 11-14 Gy), prescribed to the 80% isodose line encompassing the target, was applied. Of the 42 SRT treatments, 32 treatments consisted of 10 fractions of 3-4 Gy, and 10 patients received 25 sessions of 2 Gy, prescribed to the 100% with the 95% isodose line encompassing the planning target volume. Mean largest tumor diameter was 16.6 mm in the SRS and 24.6 mm in the SRT group. Local tumor control, cranial nerve toxicity, and preservation of useful hearing were recorded. Any new treatment-induced cranial nerve neuropathy was scored as a complication. Median follow-up was 62 months (range, 6-136 months), 5 patients progressed, resulting in an overall 5-year local tumor control of 95%. The overall 5-year facial nerve preservation probability was 88% and facial nerve neuropathy was statistically significantly higher after SRS, after prior surgery, for larger tumors, and in Koos Grade 3. The overall 5-year trigeminal nerve preservation probability was 96%, not significantly influenced by any of the risk factors. The overall 4-year probability of preservation of useful hearing (Gardner-Robertson score 1 or 2) was 68%, not significantly different between SRS or SRT (59% vs. 82%, p = 0.089, log rank). Linac-based RT results in good local control and acceptable clinical outcome in small to medium-sized vestibular schwannomas (VSs). Radiosurgery for large VSs (Koos Grade 3) remains a challenge because of increased facial nerve neuropathy. 
 Question: Which disease can be categorized using the Koos grading system?
Output: vestibular schwannoma
Context: The Giants failed to capitalize on their win from the week before and once again were defeated by the Redskins for the season sweep. Washington never trailed in this game and forced Eli Manning into three interceptions. Although the Giants recorded two off of Rex Grossman, they never were able to get into any sort of offensive groove and lost 23-10. Washington led 17-3 at halftime and never looked back. Grossman threw for 185 yards and a touchdown to Santana Moss. Jabar Gaffney led the Redskins with 85 yards receiving while Hakeem Nicks recorded 73 for the Giants. Manning finished with 257 yards. 
 Question: What was the score at the beginning of the third quarter?
Output: 17-3
Context: Clube Atletico Carlos Renaux played their home games at Estadio Augusto Bauer. 
 Question: What is the hoe stadium for Clube Atletico Carlos Renaux?
Output: estádio augusto bauer
Context: The First Rutte cabinet, also called the Rutte-Verhagen cabinet was the executive branch of the Dutch government from 14 October 2010 until 5 November 2012. 
 Question: On what date did First Rutte cabinet end?
Output: 2012
Context: ''Credit Where Credit's Due'' is the second episode of the first season of the American mystery television series Veronica Mars. 
 Question: To which series does Credit Where Credit's Due belong?
Output: veronica mars
Context: Energy from the Sun comes from the lightest element, hydrogen, fusing together to create the second lightest element, helium. Nuclear fusion on the Sun releases tremendous amounts of solar energy. The energy travels to the Earth, mostly as visible light. The light carries the energy through the empty space between the Sun and the Earth as radiation. Solar energy has been used for power on a small scale for hundreds of years, and plants have used it for billions of years. Unlike energy from fossil fuels, which almost always come from a central power plant or refinery, solar power can be harnessed locally (Figure 1.1). A set of solar panels on a homes rooftop can be used to heat water for a swimming pool or can provide electricity to the house. Societys use of solar power on a larger scale is just starting to increase. Scientists and engineers have very active, ongoing research into new ways to harness energy from the Sun more efficiently. Because of the tremendous amount of incoming sunlight, solar power is being developed in the United States in southeastern California, Nevada, and Arizona. Solar panels supply power to the Interna- tional Space Station. Solar power plants turn sunlight into electricity using a large group of mirrors to focus sunlight on one place, called a receiver (Figure 1.2). A liquid, such as oil or water, flows through this receiver and is heated to a high temperature by the focused sunlight. The heated liquid transfers its heat to a nearby object that is at a lower temperature through a process called conduction. The energy conducted by the heated liquid is used to make electricity. This solar power plant uses mirrors to focus sunlight on the tower in the center. The sunlight heats a liquid inside the tower to a very high temperature, producing energy to make electricity. Solar energy has many benefits. It is extremely abundant, widespread, and will never run out. But there are problems with the widespread use of solar power. Sunlight must be present. Solar power is not useful in locations that are often cloudy or dark. However, storage technology is being developed. The technology needed for solar power is still expensive. An increase in interested customers will provide incentive for companies to research and develop new technologies and to figure out how to mass-produce existing technologies (Figure 1.3). Solar panels require a lot of space. Fortunately, solar panels can be placed on any rooftop to supply at least some of the power required for a home or business. This experimental car is one example of the many uses that engineers have found for solar energy. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL: 
 Question: solar energy through the empty space between the sun and earth as ____________.
Output: radiation
Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nadph oxidase 1
Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nicotinamide adenine dinucleotide phosphate-oxidase 1
Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nox1
Context: At the start of World War II, the 24th Infantry was stationed at Fort Benning as school troops for the Infantry School. They participated in the Carolina Maneuvers of October - December 1941. During World War II, the 24th Infantry fought in the South Pacific Theatre as a separate regiment. Deploying on 4 April 1942 from the San Francisco Port of Embarkation, the regiment arrived in the New Hebrides Islands on 4 May 1942. The 24th moved to Guadalcanal on 28 August 1943, and was assigned to the XIV Corps. 1st Battalion deployed to Bougainville, attached to the 37th Infantry Division, from March to May 1944 for perimeter defense duty. The regiment departed Guadalcanal on 8 December 1944, and landed on Saipan and Tinian on 19 December 1944 for Garrison Duty that included mopping up the remaining Japanese forces that had yet to surrender. The regiment was assigned to the Pacific Ocean Area Command on 15 March 1945, and then to the Central Pacific Base Command on 15 May 1945, and to the Western pacific Base Command on 22 June 1945. The regiment departed Saipan and Tinian on 9 July 1945, and arrived on the Kerama Islands off Okinawa on 29 July 1945. At the end of the war, the 24th took the surrender of forces on the island of Aka-shima, the first formal surrender of a Japanese Imperial Army garrison. The regiment remained on Okinawa through 1946. 
 Question: What happened first: moved to Guadalcanal or arrived on the Kerama Islands?
Output: moved to guadalcanal
Context: The Lost Planet is a 1953 Columbia Pictures 15-chapter serial which has the distinction of being the last interplanetary-themed sound serial ever made. 
 Question: What company produced The Lost Planet?
Output: columbia pictures
Context: Aava Whistler Hotel Star Ratings: Location: Whistler Rooms:192 Stay at the Aava Whistler Hotel (formerly Coast Whistler Hotel) and experience a great vacation. The Aava Whistler Hotel is within minutes from over a hundred shopping malls and restaurants. It also has a great number of recreational facilities, including swimming, diving and even skiing. Hotel services include 24-hour reception, laundry and room service. Guests can stay in cozy rooms equipped with air-conditioning, bathroom and television. From CNY=496 per night. Best Western Cairn Croft Hotel Star Ratings: Location: East Lundy's Lane Room:l66 Relax and unwind at the Best Western Cairn Hotel. This resort-style hotel is located just minutes from the airport. At the Best Western Cairn Croft, guests can enjoy a large number of recreational facilities, including children's activities, sightseeing and a swimming pool. Business travelers can also take advantage of spacious meeting and banqueting facilities for hosting corporate events. All rooms come with basic amenities . From CNY=439 per night. Clarion Hotel&Suites Downtown Montreal Star Ratings: Location:Montreal Rooms:266 Conveniently located just 20 minutes from the airport, the Clarion Hotel&Suite Downtown Montreal is a moderately-priced three-star hotel that provides services to both business and leisure travelers. The Clarion has spacious meeting facilities and modern business centers for business travelers. It also has a sauna and whirlpool where guest can relax. All rooms come with basic amenities, including cable TV and a kitchenette. From CNY=553 per night. Delta Bow Valley Hotel Star Ratings: Location:Calgary Rooms:398 The Delta Bow Valley Hotel is located a couple of blocks north of Olympic Plaza, east of James Short Park, and north-east of the Petro-Canada Centre. Apart from business and recreational services such as a business centre, fitness centre and restaurant, all rooms in the Delta come with a mini-bar and in-house movies. From CNY=l, 227 per night. 
 Question: Which hotel offers facilities for children's activities?
Output: best western cairn croft hotel
Context: The Neponset River forms the boundary between Boston's southern neighborhoods and the city of Quincy and the town of Milton. 
 Question: What body of water was Boston next to?
Output: neponset river
Context: Rene Bliard (18 October 1932 -- 27 September 2009) was a professional French football striker who was a member of Stade de Reims in the 1950s. 
 Question: What is the name of the sports team whose member is Rene Bliard?
Output: stade de reims
Context: The Naches River is a tributary of the Yakima River in central Washington in the United States. 
 Question: What river is Naches River a tributary of?
Output: yakima river
Context: America was faced with one of its worst ever mass shootings on Friday when 20 children and six adults were shot dead by a gunman who opened fire at an elementary school in Connecticut. The gunshot atSandy Hook element school in Newtown, about 65 miles north-east.of New York, is understood to have been carried out by a gunman who was later found dead at the scene. State policeman Paul Vance said 18 children died at the scene and two more died ,n hospital.Six adults were found dead at the school, Vance said.The bodies of the victims remain inside the school. In an emotional press conference at the White House, Barack Obama suggested that he may take action.Fighting back tears, he said: "We've tolemted too many of these tragedies in the past few years.And each time I learn the news I react no.as a president, but as anybody else would - as a panent.And that was especially true today.I know there's not a parent in America who isn't in the same overwhelming sorrow that I am," Referring to a number of major shootings this year alone, Obama continued "Whether it's an elemental school in Newtown, or a shopping mall in Oregon , a temple in Wisconsin, or a movie theater in Auron, or a street comer in Chicago - these neighborhoods are our neighborhoods, and these children are our children.And we-,, going to have to come together and take meaningful action to prevent more tragedies like this, regariless of the politics." 
 Question: How many people died at the scene?
Output: 18
Context: Eugeniusz Romer died 1954 in Krakow and was buried at the Salwator Cemetery. 
 Question: What is the place of burial for Eugeniusz Romer?
Output: salwator cemetery
Context: Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, associated physical malformations and a predisposition to cancer. DBA has been associated with mutations and deletions in the large and small ribosomal protein genes, and genetic aberrations have been detected in 50-60% of patients. In this study, nine Korean DBA patients were screened for mutations in eight known DBA genes (RPS19, RPS24, RPS17, RPS10, RPS26, RPL35A, RPL5 and RPL11) using the direct sequencing method. Mutations in RPS19, RPS26 and RPS17 were detected in four, two and one patient, respectively. Among the mutations detected in RPS19, two mutations were novel (c.26T>A, c.357-2A>G). For the mutation-negative cases, array-CGH analysis was performed to identify copy-number variations, and no deletions involving the known DBA gene regions were identified. The relative mRNA expression of RPS19 estimated using real-time quantitative PCR analysis revealed two- to fourfold reductions in RPS19 mRNA expression in three patients with RPS19 mutations, and p53 protein expression analysis by immunohistochemistry showed variable but significant nuclear staining in the DBA patients. In conclusion, heterozygous mutations in the known DBA genes RPS19, RPS26 and RPS17 were detected in seven out of nine Korean DBA patients. Among these patients, RPS19 was the most frequently mutated gene. In addition, decreased RPS19 mRNA expression and p53 overexpression were observed in the Korean DBA patients, which supports the hypothesis that haploinsufficiency and p53 hyperactivation represent a central pathway underlying the pathogenesis of DBA. 
 Question: In which syndrome is the RPS19 gene most frequently mutated?
Output: dba
Context: Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, associated physical malformations and a predisposition to cancer. DBA has been associated with mutations and deletions in the large and small ribosomal protein genes, and genetic aberrations have been detected in 50-60% of patients. In this study, nine Korean DBA patients were screened for mutations in eight known DBA genes (RPS19, RPS24, RPS17, RPS10, RPS26, RPL35A, RPL5 and RPL11) using the direct sequencing method. Mutations in RPS19, RPS26 and RPS17 were detected in four, two and one patient, respectively. Among the mutations detected in RPS19, two mutations were novel (c.26T>A, c.357-2A>G). For the mutation-negative cases, array-CGH analysis was performed to identify copy-number variations, and no deletions involving the known DBA gene regions were identified. The relative mRNA expression of RPS19 estimated using real-time quantitative PCR analysis revealed two- to fourfold reductions in RPS19 mRNA expression in three patients with RPS19 mutations, and p53 protein expression analysis by immunohistochemistry showed variable but significant nuclear staining in the DBA patients. In conclusion, heterozygous mutations in the known DBA genes RPS19, RPS26 and RPS17 were detected in seven out of nine Korean DBA patients. Among these patients, RPS19 was the most frequently mutated gene. In addition, decreased RPS19 mRNA expression and p53 overexpression were observed in the Korean DBA patients, which supports the hypothesis that haploinsufficiency and p53 hyperactivation represent a central pathway underlying the pathogenesis of DBA. 
 Question: In which syndrome is the RPS19 gene most frequently mutated?
Output: diamond-blackfan anemia
Context: Summer cools down in August when the city features a lot of jazz to send excitement to any music fan. Beginning August 28, the city hosts a week of jazz performances in a variety of places. This year's annual Jazz Festival in Grant Park will offer a "tribute to New Orleans" with performers from the city, honoring the birthplace of Jazz. Jazz fans who want to be part of the week-long celebration can start with a free concert at Millennium Park's famous Pritzker Pavilion on Monday, August 28 at 6:30 pm. * Other events will include: Tuesday, August 29 -- the Jazz Institute of Chicago presents the Fourth Annual Gala Concert. Wednesday, August 30 -- Heat up Wednesday night with a ride to the best jazz hot spots and learn a bit of history of the genre with the Jazz Institute's Jazz Club Tour, which starts at 6 pm until midnight. For one low price, visit more than a dozen Jazz Clubs. The tour covers nearly every inch of Chicago. *The Chicago Jazz Festival Officially opens with a ticketed performance at the Symphony Center on Thursday, August 31. Then, the festival moves to Grant Park on Friday, September 1, for three days of free music on three stages. The event opens daily at 11 am. * Performance hours are: Jazz on Jackson Stage 12 pm -- 4:30 pm. Jazz & Heritage Family Stage 12:30 pm -- 4:30 pm. Petrillo Music Shell 5 pm -- 9:30 pm. * In addition to the music, the Chicago Jazz Festival features an art fair lying in the rose garden just south of Jackson. The fair offers all kinds of handmade crafts and artwork. 
 Question: What is special for the Chicago Jazz Festival this year?
Output: tribute to new orleans.
Context: Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul. In the past, Dr. Rubin (Arquette), who's treating their daughter (Stallard), had given them information regarding Paul's associate, Harrison (Shepard), who somehow managed to get an organ transplant for himself, possibly from the black market. Paul confronted Harrison and finally managed to get Dr. Navarro's name from him. Harrison told him that he was contacted by Navarro and he didn't know how to reach him. Back in the present day, Paul is ambushed by a couple of Navarro's guys that tell him to stay away. After an arduous search, Paul finally finds out that Dr. Navarro is actually Dr. Martinez (Perez) from a local hospital that he visited previously for his wounds. Paul confronts Martinez and asks him to find a lung donor for his daughter, who only has one week to live. Martinez agrees to help him for a $250,000 cash payment. The next day, Martinez tells Paul that he has found a matching donor for his daughter. Paul tells Diane to go to Juarez and prepare their daughter for the transplant operation. Little does Paul know that the donor is actually a live person; Martinez and his men have planned a hit-and-run accident to get the lung implant from a local street boy. Paul discovers this fact and tells Diane about it. Diane tells him that she does not want to know where the donor comes from. Paul confronts Martinez at the operating table. Martinez tells Paul to make a choice: to go ahead with the operation or disband the operation knowing that they won't be able to find another match in time to save his daughter's life. The next scene shows Paul and Diane at their daughter's funeral. Diane gives Paul an accusing look blaming him for their daughter's death. Meanwhile, elsewhere, the local boy that was supposed to be the organ donor is alive and playing soccer with his friends. 
 Question: What does Chloe need as a result of a rare degenerative disease?
Output: lung transplant
Context: The Bears hosted the 6-5 Seattle Seahawks in Week 13, who had lost five of their first six road games. The Bears started the game strong, with Brian Urlacher forcing Marshawn Lynch to fumble, and the ball was recovered by Kelvin Hayden, and Jay Cutler eventually hit Earl Bennett on a 12-yard touchdown pass. The Bears would later fail twice to expand their lead; first, Lovie Smith called for Michael Bush to run up the middle on fourth-and-one at the Seattle 15, and he was stopped for no gain. On the second occasion, Bennett dropped a potential 62-yard touchdown pass. The Seahawks capitalized on the two blunders, with rookie quarterback Russell Wilson hitting Golden Tate on a 49-yard pass, and eventually scored on Lynch's 4-yard touchdown run. Wilson would complete 23 of 37 passes for 293 yards with two touchdowns and a 104.9 passer rating while rushing for 71 yards on nine carries. Seattle then took the lead on Steven Hauschka's 31-yard field goal to close the half. Seattle would have scored a touchdown on the previous play, but Braylon Edwards dropped the potential 10-yard touchdown pass in the end zone. In the third quarter, Chicago regained the lead on Cutler's 12-yard touchdown pass to Matt Forte, but Wilson would lead the Seahawks 97 yards to take back the lead on a touchdown pass to Tate. Cutler would then hit Brandon Marshall on a 56-yard pass to set up Robbie Gould's game-tying 46-yard field goal. In overtime, the Seahawks won the toss, and Wilson took the offense 80 yards, and threw the game-winning touchdown pass to Sidney Rice. On the play, Major Wright hit Rice while he was catching the ball, appearing to knock Rice unconscious and the ball out of his hands, but the review upheld the touchdown, giving Seattle the victory. The loss dropped Chicago down to 8-4, once again tying them with the Packers for the NFC North lead. The 459 yards allowed are the most by the team all season. This would mark Urlacher's final game in a Bears' uniform. Urlacher was inactive for the final four games of the 2012 season, and he retired from the NFL on May 22, 2013. 
 Question: Who threw the first touchdown pass of the game?
Output: jay cutler
Context: Interleukin-1 (IL-1) is a potent mediator of inflammatory responses and plays a role in the differentiation of a number of lymphoid cells. In several inflammatory and autoimmune diseases, serum levels of IL-1 are elevated and correlate with disease development and severity. The central role of the IL-1 pathway in several diseases has been validated by inhibitors currently in clinical development or approved by the FDA. However, the need to effectively modulate IL-1-mediated local inflammation with the systemic delivery of an efficacious, safe and convenient drug still exists. To meet these challenges, we developed XOMA 052 (gevokizumab), a potent anti-IL-1 neutralizing antibody that was designed in silico and humanized using Human Engineering™ technology. XOMA 052 has a 300 femtomolar binding affinity for human IL-1 and an in vitro potency in the low picomolar range. XOMA 052 binds to a unique IL-1 epitope where residues critical for binding have been identified. We have previously reported that XOMA 052 is efficacious in vivo in a diet-induced obesity mouse model thought to be driven by low levels of chronic inflammation. We report here that XOMA 052 also reduces acute inflammation in vivo, neutralizing the effect of exogenously administered human IL-1 and blocking peritonitis in a mouse model of acute gout. Based on its high potency, novel mechanism of action, long half-life, and high affinity, XOMA 052 provides a new strategy for the treatment of a number of inflammatory, autoimmune and metabolic diseases in which the role of IL-1 is central to pathogenesis. 
 Question: Which molecule is targeted by the drug Gevokizumab?
Output: il-1β
Context: As a boy growing up in India, I had longed to travel abroad. I used to listen to the stories my father would tell me about his stay in Canada and tours to Europe in the 1970s, with great interest. My big moment finally came in the summer of 1998 when I was able to accompany my parents to Europe, where my father was to attend a meeting. We planned to travel to Belgium, Netherlands and West Germany. I have clear memories even today of going to Mumbai airport at night all excited about finally going abroad. I had heard several great things about Lufthansa till then but now I finally got to experience them first hand, during the flight to Frankfurt. We flew business class and even today I can remember the excellent service by the Lufthansa crew . The flight was really smooth and thoroughly enjoyable, even for someone like me, who is especially afraid of flying. After spending almost two weeks in Europe, we took the Lufthansa airport express from Dusseldorf to Frankfurt airport, for our return flight. What a journey that was! All along the Rhine , it was simply an unforgettable experience. I had a sombre feeling on the flight back to Mumbai as it marked the end of a wonderful vacation, but the Lufthansa crew members were able to change it into a most enjoyable experience yet again, with the quality of their service. Being the first airline to take me abroad, Lufthansa will always hold a special place in my heart. Even today,I continue to enjoy flights on Lufthansa and simply cannot dream of choosing any other airline. Flying, in general,for me,has always been a terrible and painful experience.Flying on Lufthansa,however, is something I always have and always will look forward to. ks5u 
 Question: Which country does the author live in now?
Output: india.
Context: The histone variant H2A.Z is a universal mark of gene promoters, enhancers, and regulatory elements in eukaryotic chromatin. The chromatin remodeler SWR1 mediates site-specific incorporation of H2A.Z by a multi-step histone replacement reaction, evicting histone H2A-H2B from the canonical nucleosome and depositing the H2A.Z-H2B dimer. Binding of both substrates, the canonical nucleosome and the H2A.Z-H2B dimer, is essential for activation of SWR1. We found that SWR1 primarily recognizes key residues within the 2 helix in the histone-fold of nucleosomal histone H2A, a region not previously known to influence remodeler activity. Moreover, SWR1 interacts preferentially with nucleosomal DNA at superhelix location 2 on the nucleosome face distal to its linker-binding site. Our findings provide new molecular insights on recognition of the canonical nucleosome by a chromatin remodeler and have implications for ATP-driven mechanisms of histone eviction and deposition. 
 Question: Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
Output: swr1
Context: Night Girl (Lydda Jath) is a fictional character in the 30th century of the DC Universe. 
 Question: With which fictional universe is the character Night Girl associated?
Output: dc universe
Context: Campaign Against Psychiatric Abuse was a group that was founded by Soviet dissident Viktor Fainberg in April 1975 and participated in the struggle against political abuse of psychiatry in the Soviet Union from 1975 to 1988. 
 Question: Which is the founder of Campaign Against Psychiatric Abuse?
Output: viktor fainberg
Context: Apparition of Face and Fruit Dish on a Beach is part of the Ella Gallup Sumner and Mary Catlin Sumner Collection of the Wadsworth Atheneum Museum of Art in Hartford, Connecticut. 
 Question: What is the name of the place where Apparition of Face and Fruit Dish on a Beach can be found?
Output: wadsworth atheneum
Context: Sidi Barrani (Egyptian Arabic: pronounced (sidi bni)) is a town in Egypt, near the Mediterranean Sea, about 95 km (59 mi) east of the border with Libya, and around 240 km (150 mi) from Tobruk, Libya. 
 Question: By which body of water is Sidi Barrani located?
Output: mediterranean sea
Context: While Chen Yi-hsiung's death was officially ruled a suicide, with both suicide notes (supposedly burned by his family) and a video of his wife apologizing for her husband's crime backing up this theory, opponents of president Chen disagree with this conclusion. 
 Question: In one word, how did Chen Yi-hsiung die?
Output: suicide
Context: On 6 June 1968, Messerschmitt AG merged with the small civil engineering and civil aviation firm Bolkow, becoming Messerschmitt-Bolkow. 
 Question: What year was the end of Messerschmitt?
Output: 1968
Context: Kirsteen O'Sullivan (born 24 November 1979) is a Scottish presenter on TV3 in Ireland. 
 Question: What is Kirsteen O'Sullivan's place of employment?
Output: tv3
Context: Transcription factor forkhead box protein P2 (FOXP2) plays an essential role in the development of language and speech. However, the transcriptional activity of FOXP2 regulated by the post-translational modifications remains unknown. Here, we demonstrated that FOXP2 is clearly defined as a SUMO target protein at the cellular levels as FOXP2 is covalently modified by both SUMO1 and SUMO3. Furthermore, SUMOylation of FOXP2 was significantly decreased by SENP2 (a specific SUMOylation protease). We further showed that FOXP2 is selectively SUMOylated in vivo on a phylogenetically conserved lysine 674 but the SUMOylation does not alter subcellular localization and stability of FOXP2. Interestingly, we observed that human etiological FOXP2 R553H mutation robustly reduces its SUMOylation potential as compared to wild-type FOXP2. In addition, the acidic residues downstream the core SUMO motif on FOXP2 are required for its full SUMOylation capacity. Finally, our functional analysis using reporter gene assays showed that SUMOylation may modulate transcriptional activity of FOXP2 in regulating downstream target genes (DISC1, SRPX2, and MiR200c). Altogether, we provide the first evidence that FOXP2 is a substrate for SUMOylation and SUMOylation of FOXP2 plays a functional role in regulating its transcriptional activity. 
 Question: Which gene is responsible for proper speech development?
Output: foxp2