niryuu/sni-each-converted huggingface dataset:
Context: Neurofibromatosis type 1 (NF1) is caused by deletions, insertions, translocations, and point mutations in the NF1 gene, which spans 350 kb on the long arm of human chromosome 17. Although several point mutations have been described, large molecular abnormalities have rarely been characterized in detail. We describe here the molecular breakpoints of a 12-kb deletion of the NF1 gene, which is responsible for the NF1 phenotype in a kindred with two children affected because of germline mosaicism in the unaffected father, who has the mutation in 10% of his spermatozoa. The mutation spans introns 31-39, removing 12,021 nt and inserting 30 bp, of which 19 bp are a direct repetition of a sequence located in intron 31, just 4 bp before the 5' breakpoint. The 5' and 3' breakpoints contain the sequence TATTTTA, which could be involved in the generation of the deletion. The most plausible explanation for the mechanism involved in the generation of this 12-kb deletion is homologous/nonhomologous recombination. Since sperm of the father does not contain the corresponding insertion of the 12-kb deleted sequence, this deletion could have occurred within the NF1 chromosome through loop formation. RNA from lymphocytes of one of the NF1 patients showed similar levels of the mutated and normal transcripts, suggesting that the NF1-mRNA from mutations causing frame shifts of the reading frame or stop codons in this gene is not degraded during its processing. The mutation was not detected in fresh lymphocytes from the unaffected father by PCR analysis, supporting the case for true germ-line mosaicism. 
 Question: Which is the gene mutated in type 1 neurofibromatosis?
Output: nf1
Context: Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensory-motor neurological disorder with a circadian component. RLS is characterized by uncomfortable sensations in the extremities, generally at night or during sleep, which often leads to an uncontrollable urge to move them for relief. Recently, genomic studies identified single-nucleotide polymorphisms in BTBD9, along with three other genes, as being associated with a higher risk of RLS. Little is known about the function of BTBD9 or its potential role in the pathophysiology of RLS. We therefore examined a line of Btbd9 mutant mice we recently generated for phenotypes similar to symptoms found in RLS patients. We observed that the Btbd9 mutant mice had motor restlessness, sensory alterations likely limited to the rest phase, and decreased sleep and increased wake times during the rest phase. Additionally, the Btbd9 mutant mice had altered serum iron levels and monoamine neurotransmitter systems. Furthermore, the sensory alterations in the Btbd9 mutant mice were relieved using ropinirole, a dopaminergic agonist widely used for RLS treatment. These results, taken together, suggest that the Btbd9 mutant mice model several characteristics similar to RLS and would therefore be the first genotypic mouse model of RLS. Furthermore, our data provide further evidence that BTBD9 is involved in RLS, and future studies of the Btbd9 mutant mice will help shine light on its role in the pathophysiology of RLS. Finally, our data argue for the utility of Btbd9 mutant mice to discover and screen novel therapeutics for RLS. 
 Question: Willis-Ekbom disease is also known as?
Output: restless legs syndrome
Context: Sir Wilfred Robarts, a famed barrister, has just been released from the hospital in which he stayed for two months following a heart attack. Returning to his practise of law, he takes the case of Leonard Vole, an unemployed man who is accused of murdering his elderly friend, Mrs. Emily French. Vole claims he's innocent, although all evidence points to him as the killer, but his alibi witness, his cold German wife Christine, instead of entering the court as a witness for the defense, becomes the witness for the prosecution and defiantly testifies that her husband is guilty of the murder. Sir Wilfred believes there's something suspicious going on with the case, particularly with Mrs. Vole. 
 Question: How long did Sir Wilfred Robarts stay int he hospital?
Output: two months
Context: The heat that is used for geothermal power may come to the surface naturally as hot springs or geysers, like The Geysers in northern California. Where water does not naturally come to the surface, engineers may pump cool water into the ground. The water is heated by the hot rock and then pumped back to the surface for use. The hot water or steam from a geothermal well spins a turbine to make electricity. Geothermal energy is clean and safe. The energy source is renewable since hot rock is found everywhere in the Earth, although in many parts of the world the hot rock is not close enough to the surface for building geothermal power plants. In some areas, geothermal power is common (Figure 1.1). In the United States, California is a leader in producing geothermal energy. The largest geothermal power plant in the state is in the Geysers Geothermal Resource Area in Napa and Sonoma Counties. The source of heat is thought to be a large magma chamber lying beneath the area. Where Earths internal heat gets close to the surface, geothermal power is a clean source of energy. In California, The Geysers supplies energy for many nearby homes and businesses. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL: 
 Question: where does geothermal energy come from?
Output: earths internal heat
Context: Isias was the daughter of King Ariobarzanes I of Cappadocia and his wife Queen Athenais Philostorgos I, while her brother was King Ariobarzanes II of Cappadocia. 
 Question: Who was the brother of Isias?
Output: ariobarzanes ii of cappadocia
Context: Marc Larumbe Gonfaus (born 30 May 1994) is a former Spanish male water polo player. 
 Question: What is the gender Marc Larumbe is associated with?
Output: male
Context: Back at home, the Dallas Cowboys traveled to Nashville to face off against the Titans. The Titans started their rookie quarterback Vince Young after veteran Kerry Collins produced dismal results after the first 3 games of the season. The Titans were able to score with a field goal on their opening drive making it the first time this season that they were able to score in the first quarter. The Titans were held to two field goals in the first half while the Cowboys had a lead at halftime with two 13-yard TD passes from Drew Bledsoe to WR Terry Glenn to put them up 14-6. The Cowboys continued to drive up the score during the 3rd quarter with a 5-yard touchdown run by RB Julius Jones. During this play Titans' DT Albert Haynesworth stepped on the face of Cowboys center Andre Gurode. Haynesworth was flagged for Unsportsmanlike Conduct and ejected from the game. He protested his ejection by taking off his helmet and throwing it on the ground. He was then flagged again with another Unsportsmanlike Conduct penalty. Gurode left the field with an ice pack to his face and required stitched above his left eye. He did not return to the field. Head Coach Jeff Fisher as well as Haynesworth later apologized for his actions. Vince Young connected for his second touchdown of the year to TE Ben Troupe. During the 4th quarter, the Cowboys scored on a field goal by Mike Vanderjagt. LB Brady James intercepted Vince Young's pass intended for Ben Troupe and returned it for a touchdown. The Cowboys sealed the win with a 7-yard TD run by Tyson Thompson with a final score of 45 to 14. The Cowboys moved to 2 and 1 while the Titans continued to losing streak dropping to 0-4. 
 Question: Which team scored more first half touchdowns?
Output: dallas cowboys
Context: Richard Packard is an American physicist, a professor at the University of California, Berkeley, known for having built the first quantum gyroscope with his colleagues. 
 Question: What is Richard Packard's place of employment?
Output: university of california, berkeley
Context: Quantitative real-time PCR (QPCR) has emerged as an accurate and valuable tool in profiling gene expression levels. One of its many advantages is a lower detection limit compared to other methods of gene expression profiling while using smaller amounts of input for each assay. Automated qPCR setup has improved this field by allowing for greater reproducibility. Its convenient and rapid setup allows for high-throughput experiments, enabling the profiling of many different genes simultaneously in each experiment. This method along with internal plate controls also reduces experimental variables common to other techniques. We recently developed a qPCR assay for profiling of pre-microRNAs (pre-miRNAs) using a set of 186 primer pairs. MicroRNAs have emerged as a novel class of small, non-coding RNAs with the ability to regulate many mRNA targets at the post-transcriptional level. These small RNAs are first transcribed by RNA polymerase II as a primary miRNA (pri-miRNA) transcript, which is then cleaved into the precursor miRNA (pre-miRNA). Pre-miRNAs are exported to the cytoplasm where Dicer cleaves the hairpin loop to yield mature miRNAs. Increases in miRNA levels can be observed at both the precursor and mature miRNA levels and profiling of both of these forms can be useful. There are several commercially available assays for mature miRNAs; however, their high cost may deter researchers from this profiling technique. Here, we discuss a cost-effective, reliable, SYBR-based qPCR method of profiling pre-miRNAs. Changes in pre-miRNA levels often reflect mature miRNA changes and can be a useful indicator of mature miRNA expression. However, simultaneous profiling of both pre-miRNAs and mature miRNAs may be optimal as they can contribute nonredundant information and provide insight into microRNA processing. Furthermore, the technique described here can be expanded to encompass the profiling of other library sets for specific pathways or pathogens. 
 Question: Which polymerase transcribes pri-miRNAs?
Output: rnapii
Context: Quantitative real-time PCR (QPCR) has emerged as an accurate and valuable tool in profiling gene expression levels. One of its many advantages is a lower detection limit compared to other methods of gene expression profiling while using smaller amounts of input for each assay. Automated qPCR setup has improved this field by allowing for greater reproducibility. Its convenient and rapid setup allows for high-throughput experiments, enabling the profiling of many different genes simultaneously in each experiment. This method along with internal plate controls also reduces experimental variables common to other techniques. We recently developed a qPCR assay for profiling of pre-microRNAs (pre-miRNAs) using a set of 186 primer pairs. MicroRNAs have emerged as a novel class of small, non-coding RNAs with the ability to regulate many mRNA targets at the post-transcriptional level. These small RNAs are first transcribed by RNA polymerase II as a primary miRNA (pri-miRNA) transcript, which is then cleaved into the precursor miRNA (pre-miRNA). Pre-miRNAs are exported to the cytoplasm where Dicer cleaves the hairpin loop to yield mature miRNAs. Increases in miRNA levels can be observed at both the precursor and mature miRNA levels and profiling of both of these forms can be useful. There are several commercially available assays for mature miRNAs; however, their high cost may deter researchers from this profiling technique. Here, we discuss a cost-effective, reliable, SYBR-based qPCR method of profiling pre-miRNAs. Changes in pre-miRNA levels often reflect mature miRNA changes and can be a useful indicator of mature miRNA expression. However, simultaneous profiling of both pre-miRNAs and mature miRNAs may be optimal as they can contribute nonredundant information and provide insight into microRNA processing. Furthermore, the technique described here can be expanded to encompass the profiling of other library sets for specific pathways or pathogens. 
 Question: Which polymerase transcribes pri-miRNAs?
Output: rna polymerase ii
Context: Since the initial approval of imatinib much has been learned about its resistance mechanisms, and efforts have continued to improve upon BCR-ABL tyrosine kinase inhibitor therapy. Targeted therapy with TKIs has continued to be an area of active research and development in the care of acute and chronic leukemia patients. This article reviews current approved and investigational TKI treatments for chronic myelogenous leukemia (CML), Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph + ALL) and acute myelogenous leukemia (AML). There are now more potent BCR-ABL TKIs approved, which allow for additional options when determining front-line and second-line CML and Ph + ALL treatments. The T315I mutation is an ever-present challenge. Ponatinib, a pan BCR-ABL TKI, while still under investigation, is very hopeful with its ability to overcome T315I mutations in resistant CML and Ph + ALL patients. Because nilotinib and dasatinib have not been directly compared, at present we recommend selecting one or the other based on the side-effect profile, drug interactions, patient comorbidities, and mutational status. FLT-3 inhibition is of particular interest in AML patients with FLT-3 internal tandem duplication mutations; this type of targeted therapy continues to be studied. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Sometimes cells need to obtain energy from sugar, but there is no oxygen present to complete cellular respiration. In this situation, cellular respiration can be anaerobic, occurring in the absence of oxygen. In this process, called fermentation, only the first step of respiration, glycolysis, occurs, producing two ATP; no additional ATP is produced. Therefore, the organism only obtains the two ATP molecules per glucose molecule from glycolysis. Compared to the 36-38 ATP produced under aerobic conditions, anaerobic respiration is not a very efficient process. Fermentation allows the first step of cellular respiration to continue and produce some ATP, even without oxygen. Yeast (single-celled eukaryotic organisms) perform alcoholic fermentation in the absence of oxygen. The products of alcoholic fermentation are ethyl alcohol (drinking alcohol) and carbon dioxide gas. This process is used to make common food and drinks. For example, alcoholic fermentation is used to bake bread. The carbon dioxide bubbles allow the bread to rise and become fluffy. Meanwhile, the alcohol evaporates. In wine making, the sugars of grapes are fermented to produce wine. The sugars are the starting materials for glycolysis. Animals and some bacteria and fungi carry out lactic acid fermentation. Lactic acid is a waste product of this process. Our muscles perform lactic acid fermentation during strenuous exercise, since oxygen cannot be delivered to the muscles quickly enough. The buildup of lactic acid is believed to make your muscles sore after exercise. Bacteria that produce lactic acid are used to make cheese and yogurt. The lactic acid causes the proteins in milk to thicken. Lactic acid also causes tooth decay, because bacteria use the sugars in your mouth for energy. Pictured below are some products of fermentation ( Figure 1.1). Products of fermentation include cheese (lactic acid fermentation) and wine (alco- holic fermentation). Behind every fart is an army of gut bacteria undergoing some crazy biochemistry. These bacteria break down the remains of digested food through fermentation, creating gas in the process. Learn what these bacteria have in common with beer brewing at [Link] . Click image to the left or use the URL below. URL: 
 Question: what process allows bread to rise?
Output: alcoholic fermentation
Context: Focal cortical dysplasias are a well-recognized cause of medically intractable seizures. The clinical relevance of certain subgroups of the International League Against Epilepsy (ILAE) classification scheme remains to be determined. The aim of the present work is to assess the effect of the focal cortical dysplasia type Ib and Ic histologic subtypes on surgical outcome with respect to seizure frequency. This study also provides an opportunity to compare the predictive value of the ILAE and Palmini et al classification schemes with regard to the type I focal cortical dysplasias. We retrospectively reviewed 91 focal cortical dysplasia patients (55% female; median age: 19 years (interquartile range 8-34); median seizure duration: 108 months (interquartile range 36-204)) with chronic epilepsy who underwent surgery. We compared the pathological subtypes, evaluating the patients' post-surgical outcome with respect to seizure frequency according to the Engel's classification and the ILAE outcome classification. Both the ILAE classification scheme and Palmini et al classification scheme were utilized to classify the histologic subtype. Using (2) and Fisher's exact tests, we compared the post-surgical outcomes among these groups. Of the 91 patients, there were 50 patients with ILAE focal cortical dysplasia type Ib, 41 with ILAE focal cortical dysplasia type Ic, 63 with Palmini et al focal cortical dysplasia type IA, and 28 with Palmini et al focal cortical dysplasia type IB. After surgery, 44 patients (48%) were seizure-free. Crude analysis revealed no significant difference between patients with subtypes of ILAE focal cortical dysplasia type I or Palmini et al focal cortical dysplasia type I concerning postoperative outcome according to the Engel and ILAE scoring systems on seizure frequency. Our findings revealed no significant difference concerning surgical outcome with respect to seizure frequency for the histologic subtypes of ILAE focal cortical dysplasia type I (Ib vs Ic) or Palmini et al focal cortical dysplasia type I (IA vs IB). In isolation, the histologic subtype of focal cortical dysplasia type I does not appear predictive of postoperative outcome. 
 Question: Which disorder is rated by Palmini classification?
Output: focal cortical dysplasia
Context: HD 113538 (Gliese 496.1) is a K-type main-sequence star of a late spectral type (K9V) that lies approximately 51 light-years away in the constellation of Centaurus. 
 Question: What is the name of the constellation where HD 113538 belongs?
Output: centaurus
Context: Atg8-family proteins are the best-studied proteins of the core autophagic machinery. They are essential for the elongation and closure of the phagophore into a proper autophagosome. Moreover, Atg8-family proteins are associated with the phagophore from the initiation of the autophagic process to, or just prior to, the fusion between autophagosomes with lysosomes. In addition to their implication in autophagosome biogenesis, they are crucial for selective autophagy through their ability to interact with selective autophagy receptor proteins necessary for the specific targeting of substrates for autophagic degradation. In the past few years it has been revealed that Atg8-interacting proteins include not only receptors but also components of the core autophagic machinery, proteins associated with vesicles and their transport, and specific proteins that are selectively degraded by autophagy. Atg8-interacting proteins contain a short linear LC3-interacting region/LC3 recognition sequence/Atg8-interacting motif (LIR/LRS/AIM) motif which is responsible for their interaction with Atg8-family proteins. These proteins are referred to as LIR-containing proteins (LIRCPs). So far, many experimental efforts have been carried out to identify new LIRCPs, leading to the characterization of some of them in the past 10years. Given the need for the identification of LIRCPs in various organisms, we developed the iLIR database ( [Link] ) as a freely available web resource, listing all the putative canonical LIRCPs identified in silico in the proteomes of 8 model organisms using the iLIR server, combined with a Gene Ontology (GO) term analysis. Additionally, a curated text-mining analysis of the literature permitted us to identify novel putative LICRPs in mammals that have not previously been associated with autophagy. 
 Question: Which web resource for LIR motif-containing proteins in eukaryotes has been developed?
Output: the ilir database
Context: Francisco Herrera Jimenez (born 29 January 1965) is a Mexican politician from the Institutional Revolutionary Party. 
 Question: From which political party is Francisco Herrera Jimenez?
Output: institutional revolutionary party
Context: In 2009 Fukushimas industries directly employed 18,678 workers and shipped 671 billion worth of goods. This was led by information-related industries with 50.5% of total output. Other industries in Fukushima include those dealing with food at 7.6% of total output, metals at 7.5%, chemistry at 5.3%, ceramics at 4.9%, electricity at 4.5%, printed goods at 2.8%, steel at 2.5%, plastics at 2.5%, and electronics at 2.2%. Other various industries make up the final 9.8%. 
 Question: Which group of industries in Fukushima is smaller: dealing with food or chemistry?
Output: chemistry
Context: Sidonie of Podebrady (Czech: Zdenka z Podebrad; 14 November 1449 -- 1 February 1510) was a daughter of George of Podebrady, King of Bohemia, and his first wife Kunigunde of Sternberg. 
 Question: Which lady gave birth to Sidonie of Podebrady?
Output: kunigunde of sternberg
Context: Barbeau Abbey (French: Abbaye de Barbeau or Abbaye Notre-Dame de Barbeau; Latin: Barbelum, Sequanae portus or Sacer portus) is a former Cistercian monastery in Fontaine-le-Port in the Seine-et-Marne department, France. 
 Question: What group was Barbeau Abbey a member of?
Output: cistercian
Context: It was the last KH-2 Corona' satellite, which was based on an Agena-B. The launch of Discoverer 28 occurred at 00:01 UTC on 4 August 1961. 
 Question: When was the launch date of Discoverer 28?
Output: 4 august 1961
Context: Xuming He (Chinese: ) is a Professor of Statistics at the University of Michigan. 
 Question: What is Xuming He's place of employment?
Output: university of michigan
Context: Just under two years after announcing his retirement, Krzysztof Kieslowski died on 13 March 1996 at age 54 during open-heart surgery following a heart attack, and was interred in Powazki Cemetery in Warsaw. 
 Question: The final resting place of Krzysztof Kieslowski is at what cemetery?
Output: powązki cemetery
Context: Protection and replenishment of a functional pancreatic -cell mass (BCM) are key goals of all diabetes therapies. Apelin, a small regulatory peptide, is the endogenous ligand for the apelin receptor (APJ) receptor. The apelin-APJ signaling system is expressed in rodent and human islet cells. Apelin exposure has been shown to inhibit and to stimulate insulin secretion. Our aim was to assess the influence of a selective APJ deletion in pancreatic islet cells on islet homeostasis and glucose tolerance in mice. Cre-LoxP strategy was utilized to mediate islet APJ deletion. APJ deletion in islet cells (APJ(islet)) resulted in a significantly reduced islet size, density and BCM. An ip glucose tolerance test showed significantly impaired glucose clearance in APJ(islet) mice. APJ(islet) mice were not insulin resistant and in vivo glucose-stimulated insulin secretion was reduced modestly. In vitro glucose-stimulated insulin secretion showed a significantly reduced insulin secretion by islets from APJ(islet) mice. Glucose clearance in response to ip glucose tolerance test in obese APJ(islet) mice fed a chronic high-fat (HF) diet, but not pregnant APJ(islet) mice, was impaired significantly. In addition, the obesity-induced adaptive elevations in mean islet size and fractional islet area were reduced significantly in obese APJ(islet) mice when compared with wild-type mice. Together, these findings demonstrate a stimulatory role for the islet cell apelin-APJ signaling axis in regulation of pancreatic islet homeostasis and in metabolic induced -cell hyperplasia. The results indicate the apelin-APJ system can be exploited for replenishment of BCM. 
 Question: What is apelin?
Output: apelin, a small regulatory peptide, is the endogenous ligand for the apelin receptor (apj) receptor.
Context: Variations serieuses, Op. 54, is a composition for solo piano by Felix Mendelssohn consisting of a theme in D minor and 17 variations. 
 Question: What instrument is Variations serieuses for?
Output: piano
Context: Acromicric dysplasia is a rare bone dysplasia characterised by short stature, short hands and feet, normal intelligence, mild facial dysmorphism, and characteristic x ray abnormalities of the hands. Only a very small number of children with this condition have been reported so far. Here we report on a series of 22 patients including 10 boys and 12 girls with acromicric dysplasia. Length was normal at birth and height fell progressively off the centiles postnatally. The mean adult height was 130 cm (133 cm in males, 129 cm in females). The hands, feet, and limbs were short and OFC was normal. Intelligence was normal and mild dysmorphic features were noted. Other occasional features included well developed muscles, a hoarse voice, generalised joint limitation in some patients, frequent ear, tracheal, and respiratory complication, and spine abnormalities. Long term follow up showed that facial dysmorphism was less obvious in adults and that carpal tunnel syndrome was frequent in older patients. Apart from short metacarpals and phalanges, internal notch of the second metacarpal, external notch of the fifth metacarpal, and internal notch of the femoral heads, there were no major x ray abnormalities. No major complications, such as cardiac disease or major orthopaedic problems, occurred in the course of the disease. The condition appeared to be sporadic in 16 cases but the observation of vertical transmission in three families was consistent with an autosomal dominant mode of inheritance. 
 Question: What is the mode of inheritance of Acromicric dysplasia?
Output: autosomal dominant
Context: Most people think the first pies were made by early Romans. They may have learned about pie making from the Greeks. These pies were sometimes made in"reeds ", which were used for the purpose of holding the filling ( ), and were not eaten. The Romans spread the word about pies around Europe and the word"pie"became a popular word in the 14th century. The first pie recipe was also published by the Romans. Pies first appeared in England as early as the twelfth century. The early pies were mostly meat pies. There was actually more crust than filling. Often these pies were made from fowl ( ) and the fowl's legs were left to hang over the side of the dish and used as handles. Fruit pies were probably first made in the 1500s. It is said that Queen Elizabeth I made the first cherry pie. Pie came to America with the first English settlers. The early settlers cooked their pies in long narrow pans. As in the Roman times, the early American pie crusts were often not eaten, but simply used to hold the filling during baking(@&*). Over the years, pie has become what it is today --- "the most traditional American dessert". Pie has become so much a part of American culture that we now often use the phrase "as American as apple pie". 
 Question: Which people might probably first grasp the skill to make pies?
Output: the greeks.
Context: In the first four years of the Chavez presidency, the economy grew at first (19992001), then contracted from 20012003 to GDP levels similar to 1997. At first, the economic decline was due to low oil prices, but it was fueled by the turmoil of the 2002 Venezuelan coup detat attempt and the Venezuelan general strike of 200203. Other factors of the decline were an exodus of capital from the country and a reluctance of foreign investors. GDP was 50.0 trillion bolivares in 1998. At the bottom of the recession in 2003, it was 42.4 trillion bolivares (in constant 1998 bolivares). However, GDP rebounded 50.1 trillion bolivares with a calmer political situation in 2004 and rose to 66.1 trillion bolivares in 2007 (both in constant 1998 bolivares). 
 Question: Was the GDP smaller in 2004 or in 2007?
Output: 2004
Context: The Malaria Policy Advisory Committee to the World Health Organization met in Geneva, Switzerland from 13 to 15 March, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting.Meeting sessions included: a review of the efficacy of artemisinin-based combination therapy in Guyana and Suriname; the outcomes from a consultation on non-malaria febrile illness; the outcomes from the second meeting of the Evidence Review Group on malaria burden estimation; an update on the review of the WHO Guidelines for the Treatment of Malaria; an update regarding progress on the constitution of the vector control Technical Expert Group; updates on the RTS, S/AS01 vaccine and the malaria vaccine technology roadmap; financing and resource allocation for malaria control; malaria surveillance and the need for a surveillance, monitoring and evaluation Technical Expert Group; criteria and classification related to malaria elimination; the next meeting of the Evidence Review Group on Intermittent Preventive Treatment in pregnancy; an update on the soon-to-be launched Elimination Scenario Planning Tool; and an update on the process for the Global Technical Strategy for Malaria Control and Elimination (2016-2025).Policy statements, position statements, and guidelines that arise from the MPAC meeting conclusions and recommendations will be formally issued and disseminated to World Health Organization Member States by the World Health Organization Global Malaria Programme. 
 Question: RTS S AS01 vaccine was developed to prevent which disease?
Output: malaria
Context: Pat came over from Ireland to England with his wife one year ago to find work. He got quite a good job with a building company, and as he did not drink or smoke, he saved up quite a lot of money. His wife's parents were still in Ireland, and one day she got a telegram saying that her mother was ill, so Pat gave her some money and she went to Ireland to see her mother. After a week, Pat wanted to write a letter to her, but he could not read or write very well, so he went to his priest and asked him to do it for him. Pat told the priest what he wanted to say, and the priest wrote it down. After a few minutes Pat stopped, and the priest said," Do you want to say more?" "Only ," 'Please excuse the bad writing and spelling'," Pat said. 
 Question: Who really made a mistake in the story?
Output: pat.
Context: The effect of levodopa (L-dopa), alone or in combination with a peripheral decarboxylase inhibitor (PDI), on plasma levels of aromatic-L-amino acid decarboxylase (ALAAD, = dopa decarboxylase), L-dopa, 3-O-methyl-dopa (3-OMD), dopamine (DA), noradrenaline, adrenaline and dopamine beta-hydroxylase has been studied. In healthy subjects and in patients with parkinsonism plasma ALAAD level fell after administration of L-dopa + benserazide, but returned to previous levels within 90 min. In a cross-sectional study blood was obtained, 2 h after dosing, from 104 patients with idiopathic parkinsonism, divided into four groups: no L-dopa treatment (group 1), L-dopa alone (group 2), L-dopa + benserazide (Madopar) (group 3) and L-dopa + carbidopa (Sinemet) (group 4). Plasma ALAAD, which was normal in groups 1 and 2, was increased 3-fold in groups 3 and 4, indicating that there was induction of ALAAD by the co-administration of PDI. Despite this induction of ALAAD, in groups 3 and 4, with half the daily L-dopa dose compared with group 2, plasma L-dopa and 3-OMD levels were 5 times higher, while plasma DA levels were not different. The DA/L-dopa ratio was decreased 5-fold in group 2 and 16-fold in groups 3 and 4 as compared with group 1. Neither 3-OMD levels nor 3-OMD/L-dopa ratios correlated with the occurrence of on-off fluctuations. In a longitudinal study of three patients started on Madopar treatment the induction of plasma ALAAD was found to occur gradually over 3-4 weeks. Further detailed pharmacokinetic studies in plasma and cerebrospinal fluid are required in order to elucidate whether the ALAAD induction by PDI may be related to the loss of clinical efficacy of combination therapy in some patients and how it is related to end-of-dose deterioration and on-off phenomena. 
 Question: Which drug is benserazide usually co-administered with?
Output: l-dopa
Context: Most sedimentary rocks form from sediments. Sediments are small pieces of other rocks, like pebbles, sand, silt, and clay. Sedimentary rocks may include fossils. Fossils are materials left behind by once-living organisms. Fossils can be pieces of the organism, like bones. They can also be traces of the organism, like footprints. Most often, sediments settle out of water (Figure 4.13). For example, rivers carry lots of sediment. Where the water slows, it dumps these sediments along its banks, into lakes and the ocean. When sediments settle out of water, they form horizontal layers. A layer of sediment is deposited. Then the next layer is deposited on top of that layer. So each layer in a sedimentary rock is younger than the layer under it. It is older than the layer over it. Sediments are deposited in many different types of environments. Beaches and deserts collect large deposits of sand. Sediments also continuously wind up at the bottom of the ocean and in lakes, ponds, rivers, marshes, and swamps. Avalanches produce large piles of sediment. The environment where the sediments are deposited determines the type of sedimentary rock that can form. Sedimentary rocks form in two ways. Particles may be cemented together. Chemicals may precipitate. Over time, deposited sediments may harden into rock. First, the sediments are compacted. That is, they are squeezed together by the weight of sediments on top of them. Next, the sediments are cemented together. Minerals fill in the spaces between the loose sediment particles. These cementing minerals come from the water that moves through the sediments. These types of sedimentary rocks are called clastic rocks. Clastic rocks are rock fragments that are compacted and cemented together. Clastic sedimentary rocks are grouped by the size of the sediment they contain. Conglomerate and breccia are made of individual stones that have been cemented together. In conglomerate, the stones are rounded. In breccia, the stones are angular. Sandstone is made of sand-sized particles. Siltstone is made of smaller particles. Silt is smaller than sand but larger than clay. Shale has the smallest grain size. Shale is made mostly of clay-sized particles and hardened mud. Chemical sedimentary rocks form when crystals precipitate out from a liquid. The mineral halite, also called rock salt, forms this way. You can make halite! Leave a shallow dish of salt water out in the Sun. As the water evaporates, salt crystals form in the dish. There are other chemical sedimentary rocks, like gypsum. Table 4.1 shows some common types of sedimentary rocks and the types of sediments that make them up. Picture Rock Name Conglomerate Type of Sedimentary Rock Clastic Breccia Clastic Sandstone Clastic Siltstone Clastic Limestone Bioclastic Coal Organic Picture Rock Name Rock Salt Type of Sedimentary Rock Chemical precipitate 
 Question: When sediments settle out of water, they form
Output: horizontal layers.
Context: On 15 December 2015, Andreze, Beaupreau, La Chapelle-du-Genet, Geste, Jallais, La Jubaudiere, Le Pin-en-Mauges, La Poiteviniere, Saint-Philbert-en-Mauges and Villedieu-la-Blouere merged becoming one commune called Beaupreau-en-Mauges. 
 Question: Which replaced the Villedieu-la-Blouere?
Output: beaupréau-en-mauges
Context: The Panthers went into the fourth quarter with a 17-3 lead over the Chiefs but things changed when Cairo Santos kicked a field goal, and Eric Berry had a pick six. Santos makes another field goal, tying the game at 17. In the Panthers' last possession of the game, the ball was stripped out of Kelvin Benjamin's hands and Kansas City gets the ball back. Santos makes the game-winning field goal for the Chiefs, and the Panthers fall to 3-6. 
 Question: Which team came out on top?
Output: the chiefs
Context: Coming off their bye week, the Lions played a Week 5 Black and Blue Division duel at home with the Chicago Bears. In the first quarter, Detroit trailed early as Bears kicker Robbie Gould got a 37-yard field goal. In the second quarter, the Lions continued to trail as QB Kyle Orton completed a 9-yard TD pass to RB Matt Forte and a 12-yard TD pass to WR/KR Devin Hester. In the third quarter, Chicago continued its domination as Forte got a 1-yard TD run, and CB Charles Tillman returned an interception 26 yards for a touchdown. Afterwards, Detroit got its only score of the game as rookie RB Kevin Smith scored on a 12-yard TD run. In the fourth quarter, the Bears sealed the win when Gould nailed a 45-yard field goal. 
 Question: Who threw the only passing touchdown of the game?
Output: kyle orton
Context: To investigate the clinicopathologic features of focal cortical dysplasia (FCD) in patients with refractory epilepsy. The clinical, radiologic and pathologic features of 38 cases of FCD receiving surgical treatment in 2005 were reviewed retrospectively. The mean age of disease onset was 9.2 years. The disease lasted for 11.9 years on average and often presented as complex partial seizure. Radiologic examination revealed hippocampal sclerosis, or abnormal signals in the grey matter in 21 cases. According to Palmini's classification system, the following pathologic subgroups were identified: FCD type IA (3/38), FCD type IB (20/38), FCD type IIA (5/38) and FCD type IIB (5/38). The remaining 5 cases were classified as mild cortical dysplasia. Topographically, FCD type II was often seen in the extratemporal region (8/10), predominantly in the frontal lobe (5/8). Dual pathology was identified only in cases with FCD type IB. Immunohistochemical study showed that the giant neurons, immature neurons and dysmorphic neurons were strongly positive for NeuN. A small number of balloon cells expressed nestin. FCD is a common cause of refractory epilepsy. FCD type IB is the predominant pathologic subtype. Associated hippocampal sclerosis is sometimes seen. Clinicopathologic differences between FCD type I and FCD type II are observed. 
 Question: Which disorder is rated by Palmini classification?
Output: focal cortical dysplasia
Context: Five teens from Sarasota, Florida, are making music from garbage. The Garbage-Men band's instruments are made from recycled objects. The guitars are boxes. A horn is made from pipes. The keyboard is formed from old bottles. The band started about two years ago. Jack Berry decided to make a playable, homemade guitar. After some trial-and-error, he ended up building it from a cereal box, a yardstick and toothpicks. After Jack showed his creation to his friend Ollie Gray, Ollie had the idea to form a band using other homemade instruments as a way to promote recycling. "We want to show people there is more to recycling than throwing things away in the bin ," Jack, 16, said, "You can actually reuse materials." Ollie, 15, plays drums made from trash cans. Evan Tucker, 15 (bass guitar); Harrison Paparatto, 15 (horns and violin); and Austin Siegel, 15, (keyboard), round out the band. The Garbage-Men plays at local events around Sarasota, including festivals, farmer's markets and community fundraisers. Typically, the teens will set up on the street and perform popular songs from the 1960s, including classic Beatles tunes and people's favorite "Wipe Out," by The Surfaris. In between sets, they talk about recycling the offer tips for how to help the environment. while they perform, Jack's little brother Trent, 11, gives out flyers about recycling and helps sell the band's CD and other merchandise. The band donates the money from sales to charity. They have raised more than $2,500 for Heifer International. The organization gives farm animals, seeds and agricultural training to people in poor countries to help end poverty and hunger. The band--all tenth graders--tries to play a gig for America's Got Talent. The teens hope to eventually take their show on the road by touring in other states. "Music is a really good way to get a good message across to people because it's really accessible," Jack says. Their instruments may be garbage, but their message isn't. 
 Question: Who first had the idea to organize the Garbage-Men band?
Output: ollie gray
Context: Succession is now regulated by laws passed by the National Diet. The current law excludes women from the succession. A change to this law had been considered until Princess Kiko gave birth to a son. Until the birth of Prince Hisahito, son of Prince Akishino, on September 6, 2006, there was a potential succession problem, since Prince Akishino was the only male child to be born into the imperial family since 1965. Following the birth of Princess Aiko, there was public debate about amending the current Imperial Household Law to allow women to succeed to the throne. In January 2005, Prime Minister Junichiro Koizumi appointed a special panel composed of judges, university professors, and civil servants to study changes to the Imperial Household Law and to make recommendations to the government. The panel dealing with the succession issue recommended on October 25, 2005, amending the law to allow females of the male line of imperial descent to ascend the Japanese throne. On January 20, 2006, Prime Minister Junichiro Koizumi devoted part of his annual keynote speech to the controversy, pledging to submit a bill allowing women to ascend the throne to ensure that the succession continues in the future in a stable manner. Shortly after the announcement that Princess Kiko was pregnant with her third child, Koizumi suspended such plans. Her son, Prince Hisahito, is the third in line to the throne under the current law of succession. On January 3, 2007, Prime Minister Shinzo Abe announced that he would drop the proposal to alter the Imperial Household Law. 
 Question: Who was born first, Prince Hisahito or Prince Akishino?
Output: prince hisahito
Context: Succession is now regulated by laws passed by the National Diet. The current law excludes women from the succession. A change to this law had been considered until Princess Kiko gave birth to a son. Until the birth of Prince Hisahito, son of Prince Akishino, on September 6, 2006, there was a potential succession problem, since Prince Akishino was the only male child to be born into the imperial family since 1965. Following the birth of Princess Aiko, there was public debate about amending the current Imperial Household Law to allow women to succeed to the throne. In January 2005, Prime Minister Junichiro Koizumi appointed a special panel composed of judges, university professors, and civil servants to study changes to the Imperial Household Law and to make recommendations to the government. The panel dealing with the succession issue recommended on October 25, 2005, amending the law to allow females of the male line of imperial descent to ascend the Japanese throne. On January 20, 2006, Prime Minister Junichiro Koizumi devoted part of his annual keynote speech to the controversy, pledging to submit a bill allowing women to ascend the throne to ensure that the succession continues in the future in a stable manner. Shortly after the announcement that Princess Kiko was pregnant with her third child, Koizumi suspended such plans. Her son, Prince Hisahito, is the third in line to the throne under the current law of succession. On January 3, 2007, Prime Minister Shinzo Abe announced that he would drop the proposal to alter the Imperial Household Law. 
 Question: Who was born first, Prince Hisahito or Prince Akishino?
Output: prince akishino
Context: The Internet will overtake radio in 2008 and become the world's fourth-largest advertising medium, a year earlier than forecast. Global spending on Internet advertising increased from 18.7 billion U.S. dollars in 2005 to 24.9 billion dollars last year, according to Zenith Optimedia, the media-buying agency. The Middle East and Asia are driving a boom in global advertising spending. Zenith predicted _ of 7.7% in spending in Asia in the run-up to the 2008 Olympic Games in Beijing. In the Middle East and Eastern Europe, advertising spending is growing faster than in North America and Western Europe, which are "maturing rapidly" as advertising markets, Zenith said. Advertising spending in the Middle East increased by 22.4% between 2005 and 2006, compared with growth of 5.2% in America and 4 per cent in Western Europe. Zenith attributed the huge percentage share in the Middle East to the growth in local economies and high oil prices. In addition to the Olympics, the U.S. presidential election and the European football championship in Austria and Switzerland next year will be the biggest contributors to overall growth during the next two years. However, Zenith noted, the market should brace itself for a fall in revenues after those big events end. 
 Question: Which has enjoyed the fastest growth of advertising spending in the last year?
Output: the middle east.
Context: School leaders from around the country gathered at the White House on November 19 for"Connected to the Future," a conference about digital technology in education.Connected is the Obama Government's five-year plan to support the growth of digital learning in schools.This growth includes equipping America's schools with high-speed broadband Internet . At the conference,President Barack Obama said the U.S.Department of Education is taking steps to help educators and school districts as they change to digital learning.The department created new guidelines to help schools work to improve their technological infrastructure .The guidelines are also designed to help schools choose the right digital devices and set up policies for their proper use. "We have to do more to offer our children a world-class education,"Obama told the crowd of school leaders."We have to improve our education level if we are going to make sure that every child in America can go as far as their dreams and talents will take them." According to Cecilia Muoz,director of the Domestic Policy Council,less than 40% of public schools in America have high-speed Internet access in their classrooms.She believes that Connected will make America a leader in using technology to educate students. Muoz mentioned the Mooresville school district as a success story.Mooresville provides each student in grades 3 through 12 with a device,and uses a mostly digital subject.Muoz said Mooresville now ranks third in test scores and second in graduation rates in the state. At the end of the president's speech,1,200 school leaders attending the event signed the Future Ready District Pledge on their iPads.It promises the education leaders to help develop a culture of learning through technology at their schools,and to support teachers and students in using technology. "Every child deserves a chance at a world-class education,"Obama added."That's what makes our nation great." 
 Question: Who will take charge of putting the plan into practice?
Output: the u.s.department of education.
Context: Eta Telescopii ( Tel, Telescopii), also known as HD 181296 or HR 7329, is a star in the southern constellation of Telescopium. 
 Question: What is the name of the constellation which Eta Telescopii belongs?
Output: telescopium
Context: Rob Larter graduated from the University of Birmingham with a PhD in Geological Sciences in 1991. 
 Question: What college did Rob Larter go to?
Output: university of birmingham