niryuu/sni-each-converted huggingface dataset:
Context: The mammalian target of rapamycin (mTOR) has been suggested as a target for radiosensitization. Given that radiotherapy is a primary treatment modality for glioblastoma (GBM) and that mTOR is often dysregulated in GBM, the goal of this study was to determine the effects of AZD2014, a dual mTORC1/2 inhibitor, on the radiosensitivity of GBM stem-like cells (GSCs). mTORC1 and mTORC2 activities were defined by immunoblot analysis. The effects of this mTOR inhibitor on the in vitro radiosensitivity of GSCs were determined using a clonogenic assay. DNA double strand breaks were evaluated according to H2AX foci. Orthotopic xenografts initiated from GSCs were used to define the in vivo response to AZD2014 and radiation. Exposure of GSCs to AZD2014 resulted in the inhibition of mTORC1 and 2 activities. Based on clonogenic survival analysis, addition of AZD2014 to culture media 1 hour before irradiation enhanced the radiosensitivity of CD133+ and CD15+ GSC cell lines. Whereas AZD2014 treatment had no effect on the initial level of H2AX foci, the dispersal of radiation-induced H2AX foci was significantly delayed. Finally, the combination of AZD2014 and radiation delivered to mice bearing GSC-initiated orthotopic xenografts significantly prolonged survival as compared with the individual treatments. These data indicate that AZD2014 enhances the radiosensitivity of GSCs both in vitro and under orthotopic in vivo conditions and suggest that this effect involves an inhibition of DNA repair. Moreover, these results suggest that this dual mTORC1/2 inhibitor may be a radiosensitizer applicable to GBM therapy. 
 Question: What does mTOR stands for?
Output: mammalian target of rapamycin
Context: De Grey Hours was purchased by Gwendoline Davies, and donated to the National Library of Wales by her sister Margaret Davies in 1951. 
 Question: What is the name of the place where De Grey Hours can be found?
Output: national library of wales
Context: A 29-year-old man presented with sudden left-sided pleuritic chest pain on a background of sore throat during the preceding week. On examination he had tender cervical lymphadenopathy, he was tachycardic and had a 24 mm Hg blood pressure difference between the left and right arms. Bloods revealed deranged liver function tests and a lymphocytosis. His D-dimer was raised, hence he was treated for presumed pulmonary embolism before imaging was available. Monospot test was positive. He subsequently had both a CT pulmonary angiogram and a CT angiogram of the aorta to exclude pulmonary embolism and aortic dissection. The CT revealed splenomegaly with a large subdiaphragmatic haematoma secondary to splenic rupture. This had likely caused referred pain through diaphragmatic irritation. He was taken to theatre for urgent splenectomy. The unifying diagnosis was infectious mononucleosis complicated by spontaneous splenic rupture secondary to Epstein-Barr virus infection. 
 Question: Which virus can be diagnosed with the monospot test?
Output: epstein-barr virus
Context: If a plant gets hungry, it cannot walk to a local restaurant and buy a slice of pizza. So, how does a plant get the food it needs to survive? Plants are producers, which means they are able to make, or produce, their own food. They also produce the "food" for other organisms. Plants are also autotrophs. Autotrophs are the organisms that collect the energy from the sun and turn it into organic compounds. Using the energy from the sun, they produce complex organic compounds from simple inorganic molecules. So once again, how does a plant get the food it needs to survive? Through photosynthesis. Photosynthesis is the process plants use to make their own food from the suns energy, carbon dioxide, and water. During photosynthesis, carbon dioxide and water combine with solar energy to create glucose, a carbohydrate (C6 H12 O6 ), and oxygen. The process can be summarized as: in the presence of sunlight, carbon dioxide + water glucose + oxygen. Glucose, the main product of photosynthesis, is a sugar that acts as the "food" source for plants. The glucose is then converted into usable chemical energy, ATP, during cellular respiration. The oxygen formed during photosynthesis, which is necessary for animal life, is essentially a waste product of the photosynthesis process. Actually, almost all organisms obtain their energy from photosynthetic organisms. For example, if a bird eats a caterpillar, then the bird gets the energy that the caterpillar gets from the plants it eats. So the bird indirectly gets energy that began with the glucose formed through photosynthesis. Therefore, the process of photosynthesis is central to sustaining life on Earth. In eukaryotic organisms, photosynthesis occurs in chloroplasts. Only cells with chloroplastsplant cells and algal (protist) cellscan perform photosynthesis. Animal cells and fungal cells do not have chloroplasts and, therefore, cannot photosynthesize. That is why these organisms, as well as the non- photosynthetic protists, rely on other organisms to obtain their energy. These organisms are heterotrophs. The Photosynthesis Song explaining photosynthesis, can be heard at Click image to the left or use the URL below. URL: Why do leaves change color each fall? This MIT video demonstrates an experiment about the different pigments in leaves. See the video at . Click image to the left or use the URL below. URL: 
 Question: as almost all organisms on earth obtain their energy from photosynthetic organisms, it could be said that ultimately all energy comes from _________.
Output: the sun.
Context: In Spring 2014, Senator Jan Veleba elected as an independent candidate in 2012, joined the Party of Civic Rights and became its chairman. 
 Question: Who led Party of Civic Rights?
Output: jan veleba
Context: Varespladib methyl is an oral secretory phospholipase A2 inhibitor that is being developed by Anthera Pharmaceuticals Inc for the potential treatment of coronary artery disease, acute coronary syndrome and inflammation. Varespladib methyl is a prodrug that is rapidly metabolized to varespladib, and both compounds are able to potently inhibit the enzymes of the human secretory phospholipase groups IIa, V and X, which play a pivotal role in atherosclerotic disease and inflammation. Phase II clinical trials of varespladib methyl in patients with coronary artery disease, rheumatoid arthritis, asthma and ulcerative colitis revealed that the drug was well tolerated. Varespladib methyl did not demonstrate a good efficacy profile in patients with rheumatoid arthritis, asthma and ulcerative colitis, whereas in patients with coronary artery disease, varespladib methyl consistently reduced LDL-cholesterol levels (elevated LDL-cholesterol levels are a marker of increased cardiovascular risk). At the time of publication, phase II trials were ongoing in patients with acute coronary syndrome and in patients undergoing elective percutaneous coronary intervention, and a phase III trial in patients with acute coronary syndrome was planned. Varespladib methyl could represent a novel therapy for the treatment of cardiovascular disease, although the efficacy, safety profile and advantages of this drug compared with existing therapeutic options would need to be established in upcoming phase III trials. 
 Question: Which enzyme is inhibited by Varespladib?
Output: secretory phospholipase a2
Context: Lupinus arcticus is a species of flowering plant in the legume family known by the common name Arctic lupine. 
 Question: Is the taxon rank of Lupinus arcticus species or genus?
Output: species
Context: Think about how the color of a piece of metal changes with temperature. A coil of an electric stove will start out black, but with added heat will start to glow a dull red. With more heat, the coil turns a brighter red, then orange. At extremely high temperatures the coil will turn yellow-white, or even blue-white (its hard to imagine a stove coil getting that hot). A stars color is also determined by the temperature of the stars surface. Relatively cool stars are red, warmer stars are orange or yellow, and extremely hot stars are blue or blue-white (Figure 1.1). Color is the most common way to classify stars. Table 1.1 shows the classification system. The class of a star is given by a letter. Each letter corresponds to a color, and also to a range of temperatures. Note that these letters dont match the color names; they are left over from an older system that is no longer used. Class O B A F G K M Color Blue Blue-white White Yellowish-white Yellow Orange Red Temperature Range 30,000 K or more 10,000-30,000 K 7,500-10,000 K 6,000-7,500 K 5,500-6,000 K 3,500-5,000 K 2,000-3,500 K Sample Star Zeta Ophiuchi Rigel Altair Procyon A Sun Epsilon Indi Betelgeuse, Proxima Cen- tauri For most stars, surface temperature is also related to size. Bigger stars produce more energy, so their surfaces are hotter. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL: 
 Question: class m stars are ________.
Output: red
Context: Chettinad Palace in Karaikudi seen in the film. Natesan (Cheran) works as an engineer in electricity board in Karaikudi and leads a joint family with more 30 of his relatives living in the same house. On the other hand, Visalakshi aka Sala (Sneha) is the only daughter to her parents and she is about to complete her college education in Karaikudi. Sala feels bored while being alone and she always prefers to have her friends surrounding her. Sala's parents start searching for a groom and they get a reference for Natesan. Sala and her family meet Natesan's family in a function. Sala is surprised to see so many people living as a joint family together and she is very much impressed and agrees for the wedding. Natesan and Sala get married. Sala loves being accompanied by all the relatives in Natesan's home. When Sala and Natesan go on a honeymoon, Sala purchases gifts for everyone in the family. All the family members are also impressed seeing Sala. But Natesan feels sad that he does not get private time to spend with his wife as they are always surrounded by relatives. Now Natesan gets transferred to a hill station named Attakatti, near Pollachi. Natesan feels happy as he believes this will provide him time to spend with Sala. Although Sala feels sad leaving all her relatives, she also goes with Natesan to the hill station. Over there in the hill station, Sala feels lonely and gets bored and she longs for the life she had in Karaikudi. Their house is located in a remote place with no neighbours and friends. Natesan also gets busy with work and has very little time to spend with his wife. Slowly Sala gets psychologically disturbed due to loneliness and she behaves as if the house is filled with so many people. Also, she repairs the fan, lights etc. purposefully in their home so that the nearby electrician (Kanja Karuppu) comes to fix them and at least she gets a chance to speak to someone. She also starts recording all the sounds around her such as birds chirping, etc. and listens to the recordings when alone. One day, she records a neighbour's child's laughter sound following which the child faints. Sala is scared but the child is saved. Doctor Ramalingam (Jayaram) sees Sala and understands that she is suffering from a disorder and warns Natesan. But Natesan does not take it seriously. One day Sala consumes too much of sleeping pills to come out of her depression. But Natesan spots her lying in bed and rushes her to the hospital. Sala is saved. Ramalingam explains the disorder to Natesan and mentions that the best cure for her would be to lead a happy life surrounded by relatives. Natesan agrees and moves back to Karaikudi. The movie ends showing Natesan and Sala leading a happy life again. 
 Question: Natesan is advised to take Sala back to the joint family when they discover what?
Output: now natesan gets transferred to a hill station named attakatti, near pollachi.
Context: Empire Field was home to the Canadian Football League's (CFL) BC Lions for the 2010 and part of the 2011 seasons, and for Major League Soccer's (MLS) Vancouver Whitecaps FC for part of their debut 2011 season. 
 Question: What team uses Empire Field?
Output: bc lions
Context: Women with Turner's syndrome (TS), who lack a complete X-chromosome, show an impairment in remembering faces and in classifying "fear" in face images. Could their difficulties extend to the processing of gaze? Three tasks, all of which rely on the ability to make use of the eye-region of a pictured face, are reported. Women with TS were impaired at judging mental state from images of the upper face ("reading the mind in the eyes"). They were also specifically impaired at interpreting "fear" from displays of the eye-region of the face. However, they showed normal susceptibility to direction of gaze as an attentional cue (social cueing), since they were as sensitive as controls to the validity of the cue, under conditions where it should be ignored. In this task, unlike those of reading the upper face for intention or expression, PIQ accounted for a significant amount of individual variance in task performance. The processing of displays of the eye region affording social and affective information is specifically affected in TS. We speculate that amygdala dysfunction is likely to be implicated in this anomalous behaviour. The presence in the female karyotype of two complete X-chromosomes is protective for some socio-cognitive abilities related to the modulation of behaviour by the interpretation of gaze. 
 Question: What chromosome is affected in Turner's syndrome?
Output: x
Context: Jules-Edouard Alboize de Pujol (1805, Montpellier -- 9 April 1854, Paris) was a French historian and playwright. 
 Question: The nationality of Jules-Edouard Alboize de Pujol is what?
Output: french
Context: McLeod syndrome is a rare X-linked hematologic and neuromuscular disorder manifested by chorea, myopathy, cardiomyopathy, areflexia, hyperCKemia, and acanthocytosis. Only four mutations have been reported in the gene responsible for McLeod syndrome. We report a novel gene mutation in a Japanese family. Direct sequencing of the PCR-amplified genomic DNA revealed the mutation was a single C-nucleotide insertion at codon 151 in exon 2 of the XK gene, which resulted in a 3'-frameshift. Study of family members revealed that the patient's mother was a manifesting carrier heterozygous for this mutation. 
 Question: Mutation of which gene is associated with McLeod syndrome?
Output: xk
Context: PECAM-1 (CD31) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing surface glycoprotein expressed on various hematopoietic cells as well as on endothelial cells. PECAM-1 has been shown to play roles in regulation of adhesion, migration and apoptosis. The BCR/ABL fusion tyrosine kinase is expressed in chronic myeloid leukemia and Philadelphia-positive (Ph+) acute lymphoblastic leukemia cells, and its inhibition by the clinically used tyrosine kinase inhibitors imatinib or dasatinib induces apoptosis of these cells. In the present study, we demonstrate that PECAM-1 is tyrosine phospho-rylated in its ITIM motifs in various BCR/ABL-expressing cells including primary leukemia cells. Studies using imatinib and dasatinib as well as transient expression experiments in 293T cells revealed that PECAM-1 was phosphorylated directly by BCR/ABL, which was enhanced by the imatinib-resistant E255K and T315I mutations, or partly by the Src family tyrosine kinases, including Lyn, which were activated dependently or independently on BCR/ABL. We also demonstrate by using a substrate trapping mutant of SHP2 that tyrosine phosphorylated PECAM-1 binds SHP2 and is a major substrate for this tyrosine phosphatase in BCR/ABL-expressing cells. Overexpression of PECAM-1 in BCR/ABL-expressing cells, including K562 human leukemia cells, enhanced cell adhesion and partially inhibited imatinib-induced apoptosis involving mitochondria depolarization and caspase-3 cleavage, at least partly, in an ITIM-independent manner. These data suggest that PECAM-1 may play a role in regulation of apoptosis as well as adhesion of BCR/ABL-expressing cells to modulate their imatinib sensitivity and would be a possible candidate for therapeutic target in Ph+ leukemias. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Ernesto Cabruna was born on 2 June 1889 in Tortona, the Kingdom of Italy. 
 Question: What is the birth place of Ernesto Cabruna?
Output: tortona
Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?
Output: spleen tyrosine kinase
Context: Franklin MacVeagh died in Chicago, Illinois, on July 6, 1934, at age 96, and was interred in Graceland Cemetery in Chicago, Illinois. 
 Question: The final resting place of Franklin MacVeagh is at what cemetery?
Output: graceland cemetery
Context: My Friend Rabbit is a children's picture book written and illustrated by Eric Rohmann. 
 Question: Who is the illustrator of My Friend Rabbit?
Output: eric rohmann
Context: Dasatinib is a dual Abl/Src tyrosine kinase inhibitor (TKI) designed as a prototypic short-acting BCR-ABL-targeted TKI that inhibits BCR-ABL with greater potency compared with imatinib, nilotinib, bosutinib, and ponatinib and has been shown to have potential immunomodulatory effects. Dasatinib is approved for the treatment of all phases of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to prior imatinib treatment and first-line treatment for CML in chronic phase. In this article, the development of dasatinib as a treatment for patients with CML is reviewed. This is a review of the relevant literature regarding dasatinib development in CML (2003-2013). Dasatinib demonstrates efficacy against most BCR-ABL mutations arising during imatinib therapy and is effective in treating patients with imatinib resistance due to other mechanisms. Randomized trial data show that first-line dasatinib provides superior responses compared with imatinib and enables patients to achieve early, deep responses correlated with improved longer-term outcomes. Dasatinib has a generally acceptable safety profile, with most adverse events (AEs) proving manageable and reversible. Cytopenias are commonly observed with dasatinib, and some nonhematologic AEs including pleural effusion have been consistently reported. Dasatinib is an effective treatment option for patients with CML. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Between 1992 and 1994, Porsche Motorsports Research and Development built and provided a full "Race" version (stripped out 968 Turbo S) for Porsches customer race teams. The 968 Turbo RS was available in two variations; a version using the K27 turbocharger from the Turbo S, which was built to the German ADAC GT specification (ballast added to bring the car up to the 1,350 kg minimum weight limit), and an international spec version which used a KKK L41 turbocharger producing and was reduced to 1,212 kg in weight. Only 4 were ever produced ; 1 Guards Red (WPOZZZ96ZNS820065), 1 Speed Yellow (WPOZZZ96ZPS896061), 1 Black (WPOZZZ96ZPS896062) and 1 White (WPOZZZ96ZPS896063). These are the rarest 968s ever produced. 
 Question: Which variation of the 968 Turbo RS weighed less?
Output: international spec version
Context: The 49ers would trail 20-13 with less than a minute to go. Blaine Gabbert would run in a game-tying 44 yard touchdown to tie the game at 20. The Bears appeared to have the game won when they went down the field after a decent kick return by Deonte Thompson for 74 yards. Robbie Gould came out to attempt a game-winning 36 yard field goal, but the kick was wide left, resulting in overtime. In the overtime period, Gabbert would throw the game-winning 71-yard touchdown pass to Torrey Smith to win the game for San Francisco. This was San Francisco's first win in Chicago since the 1989 NFC Championship Game. 
 Question: What score won the game?
Output: 71-yard touchdown pass
Context: Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light. 
 Question: Who dares Pud to climb a tree?
Output: brink
Context: Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light. 
 Question: Who dares Pud to climb a tree?
Output: mr. brinks
Context: Paul Stanton (Mulroney) and his wife Diane (Diane Kruger) are a couple whose daughter is dying from a rare degenerative lung condition. The only thing that can save her life is a lung transplant from an organ donor. The movie starts when the donated lung fails to arrive correctly. The movie goes back and forth between the present and the events leading up to it. In the present day, Paul goes to Juarez, Mexico to find a man called Dr. Navarro. After leaving his cell number at many local hospitals, somebody finally contacts Paul. In the past, Dr. Rubin (Arquette), who's treating their daughter (Stallard), had given them information regarding Paul's associate, Harrison (Shepard), who somehow managed to get an organ transplant for himself, possibly from the black market. Paul confronted Harrison and finally managed to get Dr. Navarro's name from him. Harrison told him that he was contacted by Navarro and he didn't know how to reach him. Back in the present day, Paul is ambushed by a couple of Navarro's guys that tell him to stay away. After an arduous search, Paul finally finds out that Dr. Navarro is actually Dr. Martinez (Perez) from a local hospital that he visited previously for his wounds. Paul confronts Martinez and asks him to find a lung donor for his daughter, who only has one week to live. Martinez agrees to help him for a $250,000 cash payment. The next day, Martinez tells Paul that he has found a matching donor for his daughter. Paul tells Diane to go to Juarez and prepare their daughter for the transplant operation. Little does Paul know that the donor is actually a live person; Martinez and his men have planned a hit-and-run accident to get the lung implant from a local street boy. Paul discovers this fact and tells Diane about it. Diane tells him that she does not want to know where the donor comes from. Paul confronts Martinez at the operating table. Martinez tells Paul to make a choice: to go ahead with the operation or disband the operation knowing that they won't be able to find another match in time to save his daughter's life. The next scene shows Paul and Diane at their daughter's funeral. Diane gives Paul an accusing look blaming him for their daughter's death. Meanwhile, elsewhere, the local boy that was supposed to be the organ donor is alive and playing soccer with his friends. 
 Question: Who does Paul contact when faced with the possibility of having to break the law to save his daughter's life?
Output: harrison
Context: In his works, the Gladden Fields are located where the Gladden river joins the Anduin. 
 Question: What body of water was Gladden Fields next to?
Output: anduin
Context: Coming off their Sunday night road win over the Packers, the Cowboys went home for a Week 4 NFC East showdown with the Washington Redskins. In the first quarter, the 'Boys shot first as QB Tony Romo completed a 21-yard TD pass to TE Jason Witten. In the second quarter, the Redskins took the lead as QB Jason Campbell completed a 3-yard TD pass to WR James Thrash and a 2-yard TD pass to WR Antwaan Randle El, along with kicker Shaun Suisham getting a 20-yard field goal. Dallas closed out the half with kicker Nick Folk getting a 36-yard field goal. In the third quarter, the Cowboys tied the game with Romo completing a 10-yard TD pass to WR Terrell Owens. Washington would respond with Suisham kicking a 33-yard field goal. In the fourth quarter, the Redskins increased their lead with Suisham nailing a 33-yard and a 29-yard field goal. The 'Boys tried to rally as Romo completed an 11-yard TD pass to WR Miles Austin. However, Dallas' onside kick attempt failed, preserving the Redskins' win. 
 Question: In what quarter was the longest touchdown pass?
Output: first
Context: To identify and compare the operating characteristics of existing prehospital stroke scales to predict true strokes in the hospital. We searched MEDLINE, EMBASE, and CINAHL databases for articles that evaluated the performance of prehospital stroke scales. Quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. We abstracted the operating characteristics of published prehospital stroke scales and compared them statistically and graphically. We retrieved 254 articles from MEDLINE, 66 articles from EMBASE, and 32 articles from CINAHL Plus database. Of these, 8 studies met all our inclusion criteria, and they studied Cincinnati Pre-Hospital Stroke Scale (CPSS), Los Angeles Pre-Hospital Stroke Screen (LAPSS), Melbourne Ambulance Stroke Screen (MASS), Medic Prehospital Assessment for Code Stroke (Med PACS), Ontario Prehospital Stroke Screening Tool (OPSS), Recognition of Stroke in the Emergency Room (ROSIER), and Face Arm Speech Test (FAST). Although the point estimates for LAPSS accuracy were better than CPSS, they had overlapping confidence intervals on the symmetric summary receiver operating characteristic curve. OPSS performed similar to LAPSS whereas MASS, Med PACS, ROSIER, and FAST had less favorable overall operating characteristics. Prehospital stroke scales varied in their accuracy and missed up to 30% of acute strokes in the field. Inconsistencies in performance may be due to sample size disparity, variability in stroke scale training, and divergent provider educational standards. Although LAPSS performed more consistently, visual comparison of graphical analysis revealed that LAPSS and CPSS had similar diagnostic capabilities. 
 Question: ROSIER scale is used for which disorder?
Output: stroke
Context: Osteoporosis and several other bone disorders occur when there is an imbalance between the resorption and formation components of bone remodeling activity. Therapies available for some of these conditions modulate the activity of osteoclasts and/or osteoblasts. The recent discoveries of receptor activator of NF-kappaB ligand (RANKL), an endogenous activator of osteoclastogenenesis and osteoclast activity and its inhibitor, osteoprotegerin (OPG) as pivotal regulatory factors in the pathogenesis of bone diseases like osteoporosis provide unique targets for therapeutic agents. In laboratory animals and now in humans, administering forms of OPG markedly inhibits osteoclast activity and improves bone strength, documenting that the strategy of inhibiting RANKL activity has therapeutic promise. A highly specific, fully human antibody against RANKL has been produced (denosumab) that in early studies in humans reduces bone turnover and improves bone density. Attributes of denosumab in these clinical studies include a very rapid onset of action, sustained effects for several months after a single injection, and good tolerability. These results provide the basis for studies evaluating the effectiveness of denosumab in several clinical conditions characterized by increased osteoclastic activity. 
 Question: To the ligand of which receptors does Denosumab (Prolia) bind?
Output: rankl
Context: The police must investigate a series of robberies along a strip of land in the city. The new mayor of the city (Kenneth Mars) assigns Captain Harris (G.W. Bailey) and Lt. Proctor (Lance Kinsey) to the case, but while on stakeout the Wilson gang manages to slip through their fingers.The Mayor wants Harris and Proctor to work with Police Academy head Commandant Lassard (George Gaynes) on apprehending the gang. Lassard assembles a seven-man team consisting of Hightower (Bubba Smith), Tackleberry (David Graf), Jones (Michael Winslow), Hooks (Marion Ramsey), Callahan (Leslie Easterbrook), Fackler (Bruce Mahler), and Lassard's nephew, Nick (Matt McCoy) who transfers from Miami (in the previous film Police Acdemy 5) to the city to remain close to his friends and dull-witted uncle.After distributing flyers as to the information of the Wilson gang and getting nowhere, Nick McCoy stumbles upon a paper heading of an antique diamond heading to a museum, and gets an idea to use it as bait: however the robbers nab the diamond anyway by cutting a hole in the truck and escaping through the sewer system. McCoy then decides to go undercover to get information regarding a possible hideout, but Harris decides to go undercover to get a confession.It turns out that Harris goes undercover as a window washer at a tall building, for which he has a fear of heights, and gets a confession of himself on tape after his loyal but numb-skull lacky, Proctor, accidentally knocks him over the balcony.It is revealed here that the robberies are committed by a group of three dim-witted criminals who do not seem to be able to do this on their own, and it is revealed they are being guided by a literally shadow figure known as the "Mastermind", who speaks to the three behind a wall of glass and uses a voice distortion device. He devises a plan to get the cops out of the way.Commandant Lassard and his men are later suspended after stolen jewellery from the last robbery is planted in Lassard's locker, pending an investigation. The misfit cops decide to clear Lassard's name by nabbing the gang and the ringleader. Accessing data files from a computer, McCoy deduces that the robberies are occurring along a bus route, thus intentionally lowering property values in that part of the city. They also learn that someone must be 'leaking' information to the bad guys, which is why they are always one step ahead of the Police Academy.The Police Academy force finds and does battle with the Wilson gang, while Nick chases the leader. A pursuit follows, which leads to Commissioner Hurst's (George Robertson) office. It is revealed that the Mayor is the "Mastermind" and that Captain Harris has been unwittingly leaking information during his daily meetings with the Mayor. Hurst apologizes and reinstates the force, and a plaque is given to honor the officers' bravery the next day.As the movie closes, Harris is sitting in a chair when a string tying the balloon float is cut, lifting his chair and floating him up into the air as he shouts Proctor's name. 
 Question: Who chases the leader?
Output: nick
Context: The Wnt/-catenin signaling pathway plays an essential role in osteoblast biology. Sclerostin is a soluble antagonist of Wnt/-catenin signaling secreted primarily by osteocytes. Current evidence indicates that sclerostin likely functions as a local/paracrine regulator of bone metabolism rather than as an endocrine hormone. Nonetheless, circulating sclerostin levels in humans often reflect changes in the bone microenvironment, although there may be exceptions to this observation. Using existing assays, circulating sclerostin levels have been shown to be altered in response to both hormonal stimuli and across a variety of normal physiological and pathophysiological conditions. In both rodents and humans, parathyroid hormone provided either intermittently or continuously suppresses sclerostin levels. Likewise, most evidence from both human and animal studies supports a suppressive effect of estrogen on sclerostin levels. Efforts to examine non-hormonal/systemic regulation of sclerostin have in general shown less consistent findings or have provided associations rather than direct interventional information, with the exception of mechanosensory studies which have consistently demonstrated increased sclerostin levels with skeletal unloading, and conversely decreases in sclerostin with enhanced skeletal loading. Herein, we will review the existent literature on both hormonal and non-hormonal/systemic factors which have been studied for their impact on sclerostin regulation. 
 Question: Sclerostin regulates what process?
Output: bone metabolism
Context: In May 1918, a conservative-monarchist Senate was formed by J. K. Paasikivi, and the Senate asked the German troops to remain in Finland. 3 March 1918 Treaty of Brest-Litovsk and 7 March German-Finnish agreements bound White Finland to the German Empire's sphere of influence. General Mannerheim resigned his post on 25 May after disagreements with the Senate about German hegemony over Finland, and about his planned attack on Petrograd to repulse the Bolsheviks and capture Russian Karelia. The Germans opposed these plans due to their peace treaties with Lenin. The Civil War weakened the Finnish Parliament; it became a Rump Parliament that included only three socialist representatives. On 9 October 1918, under pressure from Germany, the Senate and Parliament elected a German prince, Friedrich Karl, the brother-in-law of German Emperor William II, to become the King of Finland. The German leadership was able to utilise the breakdown of Russia for the geopolitical benefit of the German Empire in Fennoscandia also. The Civil War and the aftermath diminished independence of Finland, compared to the status it had held at the turn of the year 1917-1918. The economic condition of Finland deteriorated drastically from 1918; recovery to pre-conflict levels was achieved only in 1925. The most acute crisis was in food supply, already deficient in 1917, though large-scale starvation had been avoided that year. The Civil War caused marked starvation in southern Finland. Late in 1918, Finnish politician Rudolf Holsti appealed for relief to Herbert Hoover, the American chairman of the Committee for Relief in Belgium. Hoover arranged for the delivery of food shipments and persuaded the Allies to relax their blockade of the Baltic Sea, which had obstructed food supplies to Finland, and to allow food into the country. 
 Question: What happened first, the formation of a Senate, or the resignation of Mannerheim?
Output: senate was formed
Context: Nutrients in the foods you eat are needed by the cells of your body. How do the nutrients in foods get to your body cells? What organs and processes break down the foods and make the nutrients available to cells? The organs are those of the digestive system. The processes are digestion and absorption. The digestive system is the body system that breaks down food and absorbs nutrients. It also gets rid of solid food waste. The digestive system is mainly one long tube from the mouth to the anus, known as the gastrointestinal tract (GI tract). The main organs of the digestive system include the esophagus, stomach and the intestine, and are pictured below ( Figure 1.1). The intestine is divided into the small and large intestine. The small intestine has three segments. The ileum is the longest segment of the small intestine, which is well over 10 feet long. The large intestine is about 5 feet long. This drawing shows the major organs of the digestive system. The liver, pancreas and gallbladder are also organs of the digestive system. Digestion is the process of breaking down food into nutrients. There are two types of digestion, mechanical and chemical. In mechanical digestion, large chunks of food are broken down into small pieces. Mechanical digestion begins in the mouth and involves physical processes, such as chewing. This process continues in the stomach as the food is mixed with digestive juices. In chemical digestion, large food molecules are broken down into small nutrient molecules. This is a chemical process which also begins in the mouth as saliva begins to break down food and continues in the stomach as stomach enzymes further digest the food. Absorption is the process that allows substances you eat to be taken up by the blood. After food is broken down into small nutrient molecules, the molecules are absorbed by the blood. After absorption, the nutrient molecules travel in the bloodstream to cells throughout the body. This happens mostly in the small intestine. Some substances in food cannot be broken down into nutrients. They remain behind in the digestive system after the nutrients are absorbed. Any substances in food that cannot be digested and absorbed pass out of the body as solid waste. The process of passing solid food waste out of the body is called elimination. 
 Question: the mixing of food with stomach juices is an example of
Output: chemical digestion.
Context: Though Chad Pennington was active and in uniform for the Jets, the team erred on the side of caution due to injured right ankle, instead starting second-year backup Kellen Clemens, who was making his first career start. The Ravens' defense welcomed him rudely on his first drive with an interception by Ed Reed. The Ravens were able to attain good field position consistently throughout the first half, and quarterback Kyle Boller (who himself was starting in place of an injured starting quarterback, Steve McNair), capitalized with a two-yard touchdown to Willis McGahee late in the first quarter. The teams traded field goals to start the second quarter; Jets kicker Mike Nugent hit a 50-yard field goal, followed by Matt Stover hitting a 28-yard attempt for the Ravens. After Stover missed a 46-yard try, the Jets tried to respond with Nugent attempting a 52-yard field goal, but Nugent missed wide left, his first miss in twenty attempts dating back to last season. Boller once again took advantage of the short field provided and hit tight end Todd Heap on a four-yard touchdown with six seconds left in the half to extend the Ravens' lead to 17-3. Heap's catch was initially ruled incomplete, but the call was subjected to a booth review and reversed, as replays showed he was able to touch both feet within the end zone. After a quiet third quarter, Stover hit a 43-yard field goal to start the fourth quarter, and extended Baltimore's lead to seventeen. Baltimore's defense, which ranked as the best in the NFL in 2006, was able to shut down Clemens and the Jets for most of the game, but Clemens was able to rally the team in the fourth quarter. Using a no huddle offense, Clemens drove the team down to the Baltimore three-yard line, before the Jets settled for a 21-yard field goal. On the Jets' next possession, 44 and 24-yard strikes by Clemens to Jerricho Cotchery got the Jets to the Ravens' goal line, where he found tight end Chris Baker for a three-yard touchdown, cutting the Jets' deficit to seven. Though the Jets failed to convert the ensuing onside kick, poor clock management by Boller gave the Jets the ball back with 2:38 left in the game. Clemens immediately found Cotchery on a 50-yard catch-and-run, later followed by a 24-yard pass to Laveranues Coles that brought the Jets' to the Baltimore seven-yard line with just over a minute to go. Clemens passed to Justin McCareins for a potential touchdown, but the pass was dropped by McCareins. A second pass to McCareins in the end zone deflected off him and into the arms of Ravens linebacker Ray Lewis for the game-ending interception. The loss made the Jets 8-20 since 2002 in games not started by Chad Pennington. 
 Question: From what yard line did Mike Nugent miss a field goal in the second quarter?
Output: 52-yard