niryuu/sni-each-converted huggingface dataset:
Context: The Romano-Ward long-QT Syndrome (LQTS) is an autosomal dominant inherited trait characterized by prolonged QT interval on ECG, life-threatening arrhythmias, syncope, and sudden death in affected individuals. A gene responsible for this disorder has been shown to be linked to the Harvey ras-1 locus (H-ras-1) DNA marker on the short arm of chromosome 11 (11p) in 7 families. The purpose of this study was to determine, by analyzing 23 families with LQTS for linkage to chromosome 11p, whether evidence exists for more than one gene causing LQTS (ie, locus heterogeneity). Twenty-three families (262 family members) were clinically evaluated using medical histories, ECGs, and Holter recordings. Each corrected QT interval (QTc) were determined using Bazett's formula. Blood for DNA extraction and cell line immortalization was obtained after informed consent. Southern blotting and polymerase chain reaction were performed, and linkage analysis carried out using the LINKAGE computer program (v 5.03). Genetic heterogeneity was determined using the HOMOG 2 (v 2.51) computer program. Twenty-three families were studied for evidence of linkage to chromosome 11p using the H-ras-1 locus probe pTBB-2 and multiple flanking markers, including tyrosine hydroxylase (TH). Two-point linkage analysis using pTBB-2 and TH markers was consistent with linkage in 15 of 23 families, with the maximum single-family LOD score of +3.038 occurring at theta = 0. However, 8 of 23 families had negative LOD scores, with the values in 4 families being less than -2 at theta = 0, consistent with exclusion of linkage. Analysis with the HOMOG program was consistent with genetic heterogeneity (P < .0001). Multipoint linkage data using pTBB-2 and TH were also examined for evidence of heterogeneity. HOMOG analysis of multipoint LOD scores from 100 cM surrounding the H-ras-1 locus also supported heterogeneity (P < .001). In the 23 families with LQTS analyzed for linkage to the H-ras-1 locus on chromosome 11p15.5, 15 of 23 families had LOD scores consistent with linkage. The remaining 8 of 23 families had negative LOD scores, 4 of which were definitively excluded from linkage. Thus, genetic heterogeneity is definitively (P < .001) demonstrated for this disorder. 
 Question: What is the mode of inheritance of Romano Ward long QT syndrome?
Output: autosomal dominant
Context: The Slovak National Uprising (Slovak: Slovenske narodne povstanie, abbreviated SNP) or 1944 Uprising was an armed insurrection organized by the Slovak resistance movement during World War II. It was launched on 29 August 1944 from Banska Bystrica in an attempt to resist German troops that had occupied Slovak territory and to overthrow the collaborationist government of Jozef Tiso. 
 Question: What year did Slovak National Uprising start?
Output: 29 august 1944
Context: ''Calling Hong Kong'' was the second single by Orange County pop punk band Supernova, released on 7'' by Goldenrod Records in 1993. 
 Question: Which singer-songwriter is Calling Hong Kong the fifth studio album of?
Output: supernova
Context: There were 22,000 households of which 37.1% had children under the age of 18 living with them, 48.3% were Marriage living together, 12.7% had a female householder with no husband present, 5.1% had a male householder with no wife present, and 33.9% were non-families. 26.7% of all households were made up of individuals and 7.5% had someone living alone who was 65 years of age or older. The average household size was 2.70 and the average family size was 3.24. 
 Question: Which group for households is smaller: average family size or average household size?
Output: average household size
Context: Arnold of Selenhofen (c. 1095/1100 -- 24 June 1160) was the archbishop of Mainz from 1153 to his assassination in the benedictine abbey St. Jakob, where he took shelter from the raging crowd. 
 Question: Was the death of Arnold of Selenhofen an accident or suicide?
Output: assassination
Context: Mahjong, that favorite pastime of "old folks" in Shanghai, is finding a new audience among younger players, and many university students are becoming mad about this traditional Chinese game. Students at Fudan University have even formed a Mahjong club. This resurgence of the game, however, is not without its critics. Some people still associate the game with gambling and for many years Mahjong was banned in China. One critic, surnamed Meng, was quoted as saying, "Mahjong is a bad custom that will distract students from studies." But Yu Guangyuan, former vice-president of the Chinese Academy of Social Sciences , says Mahjong is a "healthy, scientific, friendly mind game." Mr. Yu's opinion seems to be shared by the majority of Chinese. They see the game as an activity that requires great concentration and intellectual skill. They also see the game as an important part of Chinese culture and a pastime that brings family and friends closer together. This Spring Festival many families will no doubt spend hours around the Mahjong table getting reacquainted with each other. For them, playing Mahjong is a way of spending quality family time. No one knows who invented Mahjong. Some say it was Confucius, others say the current form of the game was developed right here in Shanghai in the late19th century. It is certainly because of Shanghai that the game enjoys its worldwide popularity. It was brought to America in the 1920s and has since spread throughout Europe and other parts of Asia. There is now a World Championship of Mahjong which is held every year. This year's championship was held in Chongqing and attracted players from America, Europe and Russia, as well as students from Peking University, Tshinghua University and Nankai University. There was no prize money, but the players delighted in using their wits and their understanding of statistics and probability theory to defeat their clever opponents. Of course, Mahjong doesn't have to always be that intense. For young people it can be a way to relax and to socialize, a chance to get away from their computers and talk to other people face to face. So, this Spring Festival, why not get out the "old folks" tiles: it's good to be mad about Mahjong! 
 Question: What is the best title of the passage?
Output: mad about mahjong
Context: To elucidate the phenotype, genotype, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and mutation carriers. The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analysis of Notch3, clinical and MRI findings were correlated in 27 mutation carriers. Notch3 mutation sites were C174R (one family, n = 3), R133C (one family, n = 3), R587C (one family, n = 1), R544C (two families, n = 5), and R75P (four families, n = 15). The clinical features were typical of CADASIL, but the frequency of migraine in the Korean population appears low. MRI abnormalities were found in 54% of the mutant carriers, the most common being white matter hyperintensities. The prevalence of lacunes and microbleeds increased with patient age. Anterior temporal areas were less often involved in subjects with R75P mutations than in those where mutations occurred in other sites (p = 0.02). Gradient echo imaging identified microbleedings in 33% of mutation carriers (64% of those with abnormal MRI), whereas diffusion-weighted MRI showed abnormal findings in only one patient. Neurologic disability was related to the number of lacunar infarcts and the lesion volume of white matter hyperintensities (p < 0.001) whereas MMSE score was related to the number of lacunar infarcts (p < 0.005). Although Korean cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mutation carriers show similar clinical and MRI findings, these abnormalities appear less frequently than in other populations. Relatively frequent microbleedings on gradient echo imaging suggest that treatment should be individualized according to MRI findings. The novel mutation of R75P, not involving a cysteine residue, is related to less frequent involvement of the anterior temporal area, thus broadening the spectrum of CADASIL. 
 Question: Which amino acid residue appears mutated in most of the cases reported with cadasil syndrome?
Output: cysteine
Context: On July 24, 2017, Gasol re-signed with the Spurs. On December 20, 2017, he had 20 points and a season-high 17 rebounds in a 93-91 win over the Portland Trail Blazers. On December 23, 2017, he recorded his 10th career triple-double with 14 points, 11 rebounds and a season-high 10 assists in a 108-99 win over the Sacramento Kings. On December 26, 2017, in a 109-97 win over the Brooklyn Nets, Gasol collected his 10,817th rebound, moving him past Jack Sikma for 30th in league history. On January 26, 2018, in a 97-78 loss to the Philadelphia 76ers, Gasol became the 34th player in NBA history to play 40,000 career minutes. On March 25, 2018, he had 22 points on 10-of-15 shooting and grabbed 13 rebounds in a 106-103 loss to the Milwaukee Bucks. 
 Question: Did Gasol's team score more points against the Brooklyn Nets or the Milwaukee Bucks?
Output: brooklyn nets
Context: Ian Syster and his two-month-old son drowned in December 2004 in Keimoes following a car accident. 
 Question: What was the cause of death of Ian Syster?
Output: accident
Context: A Fate Totally Worse than Death is a spoof horror novel for young adults by Paul Fleischman, published in 1995, in which a badly behaved clique of high school girls get their comeuppance. 
 Question: What year was A Fate Totally Worse than Death made?
Output: 1995
Context: Since 2011, the mayor of Kvalsund is Ragnar Olsen, who represents the Labour Party. 
 Question: Who was in charge of Kvalsund?
Output: ragnar olsen
Context: The Van Gogh Museum's Wheatfield with Crows was painted in July 1890, in the last weeks of van Gogh's life. 
 Question: What is the name of the place where Wheatfield with Crows can be found?
Output: van gogh museum
Context: The limited availability of effective drugs causes difficulties in the management of multidrug-resistant tuberculosis (MDR-TB) and novel therapeutic agents are needed. Delamanid , a new nitro-hydro-imidazooxazole derivative, inhibits mycolic acid synthesis. This review covers the efficacy and safety of delamanid for MDR-TB. This paper reviews the pharmacological profile of delamanid and the results of clinical trials evaluating its efficacy for treating MDR-TB in combination with other anti-TB drugs. The drug's safety and tolerability profiles are also considered. Delamanid showed potent activity against drug-susceptible and -resistant Mycobacterium tuberculosis in both in vitro and in vivo studies. In clinical trials, the drug showed significant early bactericidal activity in pulmonary TB patients, and increased culture conversion after 2 months of treatment in combination with an optimized background regimen in MDR-TB patients. In addition, decreased mortality was observed in MDR-TB patients who received > 6 months of delamanid treatment. The drug was generally tolerable, but QT prolongation should be monitored carefully using electrocardiograms and potassium levels. Therefore, delamanid could be used as part of an appropriate combination regimen for pulmonary MDR-TB in adult patients when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability. 
 Question: Which disease can be treated with Delamanid?
Output: tuberculosis
Context: Uranus (YOOR-uh-nuhs) is named for the Greek god of the sky. From Earth, Uranus is so faint that it was unnoticed by ancient observers. William Herschel first discovered the planet in 1781. Although Uranus is very large, it is extremely far away, about 2.8 billion km (1.8 billion mi) from the Sun. Light from the Sun takes about 2 hours and 40 minutes to reach Uranus. Uranus orbits the Sun once about every 84 Earth years. Uranus has a mass about 14 times the mass of Earth, but it is much less dense than Earth. Gravity at the surface of Uranus is weaker than on Earths surface, so if you were at the top of the clouds on Uranus, you would weigh about 10% less than what you weigh on Earth. Like Jupiter and Saturn, Uranus is composed mainly of hydrogen and helium, with an outer gas layer that gives way to liquid on the inside. Uranus has a higher percentage of icy materials, such as water, ammonia (NH3 ), and methane (CH4 ), than Jupiter and Saturn. When sunlight reflects off Uranus, clouds of methane filter out red light, giving the planet a blue-green color. There are bands of clouds in the atmosphere of Uranus, but they are hard to see in normal light, so the planet looks like a plain blue ball. Most of the planets in the solar system rotate on their axes in the same direction that they move around the Sun. Uranus, though, is tilted on its side, so its axis is almost parallel to its orbit. In other words, it rotates like a top that was turned so that it was spinning parallel to the floor. Scientists think that Uranus was probably knocked over by a collision with another planet-sized object billions of years ago. Uranus has a faint system of rings (Figure 1.1). The rings circle the planets equator, but because Uranus is tilted on its side, the rings are almost perpendicular to the planets orbit. This image from the Hubble Space Tele- scope shows the faint rings of Uranus. The planet is tilted on its side, so the rings are nearly vertical. Uranus has 27 known moons and all but a few of them are named for characters from the plays of William Shakespeare. The five biggest moons of Uranus Miranda, Ariel, Umbriel, Titania, and Oberon are shown in Figure 1.2. These Voyager 2 photos have been resized to show the relative sizes of the five main moons of Uranus. Click image to the left or use the URL below. URL: 
 Question: who first discovered uranus?
Output: william herschel
Context: An old farmer lived on a farm with his young grandson. Each morning Grandpa was up early to read his Bhagavat Geeta. His grandson wanted to be just like him and tried to imitate him in every way he could. One day the grandson asked, "Grandpa! I try to read the Bhagavat Geeta just like you but I don't understand it, What good does reading the Bhagavat Geeta do?" The Grandfather quietly turned from putting coal in the stove and replied, "Take this coal basket down to the river and bring me back a basket of water." The boy did as he was told, but all the water leaked out before he got back to the house. The grandfather laughed and said, "You'll have to move a little faster next time," and sent him back to the river with the basket to try again. This time the boy ran faster, but again the same took place. He told his grandfather that it was impossible to carry water with a basket. The old man said, " You're just not trying hard enough," So the boy again dipped the basket into the river and ran hard, but when he reached his grandfather the basket was again empty. he said, "See Grandpa, it's useless!" "So you think it is useless?" The old man said, "Look at the basket." The boy looked at the basket and for the first time realized that the basket was different. It had been transformed from a dirty old coal basket into a clean one inside and outside. "You might not understand or remember everything, but when you read it, you will be changed, inside and out. That is the work of Krishna in our lives." 
 Question: What would the grandson like to do in the future?
Output: to read the bhagavat geeta.
Context: Chronic myeloid leukemia (CML) is characterized by formation of a BCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22. Recently the development of new fluorescence in-situ hybridization (FISH) techniques has allowed identification of unexpected deletions of the reciprocal translocation product, the derivative chromosome 9, in 10% to 15% of patients with CML. These deletions are large, span the translocation breakpoint, and occur at the same time as the Ph translocation. Such deletions therefore give rise to previously unsuspected molecular heterogeneity from the very beginning of this disease, and there is mounting evidence for similar deletions associated with other translocations. Several studies have demonstrated that CML patients who carry derivative chromosome 9 deletions exhibit a more rapid progression to blast crisis and a shorter survival. Deletion status is independent of, and more powerful than, the Sokal and Hasford/European prognostic scoring systems. The poor prognosis associated with deletions is seen in patients treated with hydroxyurea or interferon, and preliminary evidence suggests that patients with deletions may also have a worse outcome than nondeleted patients following stem cell transplantation or treatment with imatinib. Poor outcome cannot be attributed to loss of the reciprocal ABL-BCR fusion gene expression alone, and is likely to reflect loss of one or more critical genes within the deleted region. The molecular heterogeneity associated with the Philadelphia translocation provides a new paradigm with potential relevance to all malignancies associated with reciprocal chromosomal translocations and/or fusion gene formation. 
 Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
Output: the bcr/abl gene fusion
Context: Chronic myeloid leukemia (CML) is characterized by formation of a BCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22. Recently the development of new fluorescence in-situ hybridization (FISH) techniques has allowed identification of unexpected deletions of the reciprocal translocation product, the derivative chromosome 9, in 10% to 15% of patients with CML. These deletions are large, span the translocation breakpoint, and occur at the same time as the Ph translocation. Such deletions therefore give rise to previously unsuspected molecular heterogeneity from the very beginning of this disease, and there is mounting evidence for similar deletions associated with other translocations. Several studies have demonstrated that CML patients who carry derivative chromosome 9 deletions exhibit a more rapid progression to blast crisis and a shorter survival. Deletion status is independent of, and more powerful than, the Sokal and Hasford/European prognostic scoring systems. The poor prognosis associated with deletions is seen in patients treated with hydroxyurea or interferon, and preliminary evidence suggests that patients with deletions may also have a worse outcome than nondeleted patients following stem cell transplantation or treatment with imatinib. Poor outcome cannot be attributed to loss of the reciprocal ABL-BCR fusion gene expression alone, and is likely to reflect loss of one or more critical genes within the deleted region. The molecular heterogeneity associated with the Philadelphia translocation provides a new paradigm with potential relevance to all malignancies associated with reciprocal chromosomal translocations and/or fusion gene formation. 
 Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
Output: abl/bcr fusion
Context: Born in Brognard, France, in the department of Doubs near Montbeliard, Pierre Widmer was raised in a Mennonite family. 
 Question: Where did Pierre Widmer live when he died?
Output: montbéliard
Context: Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal transduction initiated by activated receptors for immunoglobulin G. In collagen-induced arthritis, R788/R406, a novel and potent small molecule Syk inhibitor suppressed clinical arthritis, bone erosions, pannus formation, and synovitis. Serum anti-collagen type II antibody levels were unaltered, while the half-life of exogenous antibody was extended when co-administered with R406. Expression of the targeted kinase (Syk) in synovial tissue correlated with the joint level of inflammatory cell infiltrates and was virtually undetectable in treated rats. Syk inhibition suppressed synovial cytokines and cartilage oligomeric matrix protein (COMP) in serum, suggesting a sensitive and reliable biomarker for R406 activity. These results highlight the role of activating Fcgamma receptors in inflammatory synovitis and suggest that interruption of the signaling cascade with a novel Syk inhibitor may be a useful addition to immunosuppressive disease-modifying anti-rheumatic drugs currently used in the treatment of human autoimmune diseases such as rheumatoid arthritis. 
 Question: Which enzyme is inhibited by a drug fostamatinib?
Output: spleen tyrosine kinase
Context: Kolding Stadion, nicknamed rneborgen by the local team's fanclub after Kolding FC's impressive home record of the 2005 autumn-season (just one loss). 
 Question: What team uses Kolding Stadion?
Output: kolding fc
Context: The Spanish policy evolved to make peace with the Chichimecas had four components: negotiation of peace agreements, welcoming conversion, instead of forcing conversion to Catholicism with missionaries, encouraging native allies to settle the frontier to serve as examples and role models, and providing food, other commodities, and tools to potentially hostile natives. This established the pattern of Spanish policy for assimilating natives on their northern frontier. The principal components of the policy of purchase for peace would continue for nearly three centuries and would not be as successful, as later threats from hostile natives such as Apaches and Comanches would demonstrate and as Spaniards would still value any means to riches and break treaties with natives. After the Chichimeca War, the Purchase for Peace Program gradually corrupted. Many Spanish Loyalist resented the defeat. The Spanish loyalist attempted enslavement for mining and agricultural labor, enforced harsh working conditions to the lower social classes, and implemented extremely oppressive political and economic systems against the native and mestizo populations of Mexico. The Catholic Church sustained the Mexican Inquisition torturing and killing hundreds of people who did not convert to Catholicism. The Mexican Inquisition was first abolished by decree in 1812. However, political tensions and chaos led to something of its return between 1813 and 1820. It was abolished in 1820. This societal tension during this period contributed to the initiation of the Mexican War of Independence; which started in 1810 and ended in 1821. 
 Question: Which happened first, the Mexican War of Independence, or the decree to abolish the Mexican Inquisition?
Output: mexican war of independence
Context: Lacus Oblivionis (latin for ''Lake of Forgetfulness'') is a small lunar mare on the surface of the Moon. 
 Question: The astronomical body that Lacus Oblivionis is on is what?
Output: moon
Context: Chiang Wei-shui (February 8, 1891--August 5, 1931) was a founder of the Taiwanese Cultural Association and the Taiwanese People's Party. 
 Question: The birth date of Chiang Wei-shui is what?
Output: 1891
Context: Recurrent syncope, malignant ventricular arrhythmias, and sudden death are complications of the long QT syndrome (LQTS). Two well-known syndromes with long QT intervals are known. The Jervell and Lange-Nielsen syndrome (JLNS) is characterized by prolongation of the QT interval, deafness, and autosomal-recessive inheritance, and the Romano-Ward syndrome is characterized by a prolonged QT interval, autosomal-dominant inheritance, and no deafness. In the present study assessment was performed of the diagnostic importance of the ventricular derepolarization parameters, clinical features, and prevalence of JLNS among 132 children with congenital hearing loss (CHL). In the CHL group the mean QT, QTc, JT, and JTc intervals and the dispersion values (QT-d, JT-d, QTc-d, and JTc-d) were significantly longer than those of control subjects (n = 96) (P < 0.05). Patients with CHL and JLNS (n = 5) had significantly longer mean values of QT, QTc, JT, and JTc intervals and dispersion values than those of CHL without JLNS (n = 127) and control subjects (P < 0.05). The results suggest that assessment of ventricular derepolarization parameters in children with CHL will be helpful in the early detection of JLNS because infants with CHL cannot accurately describe the symptoms of syncope. 
 Question: What is the mode of inheritance of Romano Ward long QT syndrome?
Output: autosomal dominant
Context: Recurrent syncope, malignant ventricular arrhythmias, and sudden death are complications of the long QT syndrome (LQTS). Two well-known syndromes with long QT intervals are known. The Jervell and Lange-Nielsen syndrome (JLNS) is characterized by prolongation of the QT interval, deafness, and autosomal-recessive inheritance, and the Romano-Ward syndrome is characterized by a prolonged QT interval, autosomal-dominant inheritance, and no deafness. In the present study assessment was performed of the diagnostic importance of the ventricular derepolarization parameters, clinical features, and prevalence of JLNS among 132 children with congenital hearing loss (CHL). In the CHL group the mean QT, QTc, JT, and JTc intervals and the dispersion values (QT-d, JT-d, QTc-d, and JTc-d) were significantly longer than those of control subjects (n = 96) (P < 0.05). Patients with CHL and JLNS (n = 5) had significantly longer mean values of QT, QTc, JT, and JTc intervals and dispersion values than those of CHL without JLNS (n = 127) and control subjects (P < 0.05). The results suggest that assessment of ventricular derepolarization parameters in children with CHL will be helpful in the early detection of JLNS because infants with CHL cannot accurately describe the symptoms of syncope. 
 Question: What is the mode of inheritance of Romano Ward long QT syndrome?
Output: autosomal-dominant
Context: Tsunami are deadly ocean waves from the sharp jolt of an undersea earthquake. Less frequently, these waves can be generated by other shocks to the sea, like a meteorite impact. Fortunately, few undersea earthquakes, and even fewer meteorite impacts, generate tsunami. Tsunami waves have small wave heights relative to their long wavelengths, so they are usually unnoticed at sea. When traveling up a slope onto a shoreline, the wave is pushed upward. As with wind waves, the speed of the bottom of the wave is slowed by friction. This causes the wavelength to decrease and the wave to become unstable. These factors can create an enormous and deadly wave. Landslides, meteorite impacts, or any other jolt to ocean water may form a tsunami. Tsunami can travel at speeds of 800 kilometers per hour (500 miles per hour). Since tsunami are long-wavelength waves, a long time can pass between crests or troughs. Any part of the wave can make landfall first. In 1755 in Lisbon, Portugal, a tsunami trough hit land first. A large offshore earthquake did a great deal of damage on land. People rushed out to the open space of the shore. Once there, they discovered that the water was flowing seaward fast and some of them went out to observe. What do you think happened next? The people on the open beach drowned when the crest of the wave came up the beach. Large tsunami in the Indian Ocean and more recently Japan have killed hundreds of thousands of people in recent years. The west coast is vulnerable to tsunami since it sits on the Pacific Ring of Fire. Scientists are trying to learn everything they can about predicting tsunamis before a massive one strikes a little closer to home. Although most places around the Indian Ocean did not have warning systems in 2005, there is a tsunami warning system in that region now. Tsunami warning systems have been placed in most locations where tsunami are possible. Click image to the left or use the URL below. URL: 
 Question: tsunami can travel at speeds of
Output: 800 kilometers per hour
Context: The 2012 Michoacan murder of photographers concerns two Mexican freelance photographers, Arturo Barajas Lopez (1966? - 19 August 2012) and Jose Antonio Aguilar Mota (1986? - 19 August 2012), who were kidnapped on 16 August 2012 and found murdered in Ecuandureo, Michoacan, Mexico. 
 Question: The point in time of 2012 Michoacan murder of photographers was when?
Output: 19 august 2012
Context: The genetic information of the cell, or DNA, is stored in the nucleus. During mitosis, two nuclei (plural for nucleus) must form, so that one nucleus can be in each of the new cells after the cell divides. In order to create two genetically identical nuclei, DNA inside of the nucleus must be copied or replicated. This occurs during the S phase of the cell cycle. During mitosis, the copied DNA is divided into two complete sets, so that after cytokinesis, each cell has a complete set of genetic instructions. To begin mitosis, the DNA in the nucleus wraps around proteins to form chromosomes. Each organism has a unique number of chromosomes. In human cells, our DNA is divided up into 23 pairs of chromosomes. Replicated DNA forms a chromosome made from two identical sister chromatids, forming an "X" shaped molecule ( Figure 1.1). The two chromatids are held together on the chromosome by the centromere. The centromere is also where spindle fiber microtubules attach during mitosis. The spindles separate sister chromatids from each other. During mitosis, the two sister chromatids must be divided. This is a precise process that has four individual phases to it. After the sister chromatids separate, each separate chromatid is now known as a chromosome. Each resulting chromosome is made of DNA from just one chromatid. So, each chromosome after this separation is made of "1/2 of the X." Through this process, each daughter cell receives one copy of each chromosome. The four phases of mitosis are prophase, metaphase, anaphase and telophase ( Figure 1.2). 1. Prophase: The chromatin, which is unwound DNA, condenses forming chromosomes. The DNA becomes so tightly wound that you can see them under a microscope. The membrane around the nucleus, called the nuclear envelope, disappears. Spindles also form and attach to chromosomes to help them move. 2. Metaphase: The chromosomes line up in the center, or the equator, of the cell. The chromosomes line up in a row, one on top of the next. 3. Anaphase: The two sister chromatids of each chromosome separate as the spindles pull the chromatids apart, resulting in two sets of identical chromosomes. 4. Telophase: The spindle dissolves and nuclear envelopes form around the chromosomes in both cells. An overview of the cell cycle and mito- sis: during prophase the chromosomes condense, during metaphase the chromo- somes line up, during anaphase the sister chromatids are pulled to opposite sides of the cell, and during telophase the nuclear envelope forms. This is a representation of dividing plant cells. Cell division in plant cells differs slightly from animal cells as a cell wall must form. Note that most of the cells are in interphase. Can you find examples of the different stages of mitosis? 
 Question: when do spindles form and attach to chromosomes?
Output: prophase
Context: We all love festivals. But since culture develops differently in many places, some festivals are, to us, very strange. Let's take a look at some unique festivals around the world. Cheese Rolling Festival (England) The festival started in the 15thcentury in May. When a round cheese is rolled, competitors run down the hill and try to catch it before it reaches the bottom. As the cheese can reach speeds of up to 112 km/h, it's rare that someone catches the cheese. First to the bottom wins the cheese. But running down a very steep hill behind a cheese can be dangerous. Eight people were injured in 1992. Roswell UFO festival (New Mexico, US) The Roswell UFO festival celebrates the anniversary of the "Roswell Incident", when a UFO was said to have crashed nearby. Every year in July, experts, authors, researches and lecturers come to discuss the incident. The celebration also includes an alien parade, an alien costume contest, and an alien hot air balloon ride. Hemingway Days (Florida, US) This festival has normal stuff (,) like short-story readings and exhibits about the author. But the highlight of the festival is definitely the Hemingway look alike contest. Imagine walking into a bar and being greeted by 20 middle-aged men who all look alike: stocky with thick white beards. The festival takes place in mid-July every year. 
 Question: Which festival takes place in mid-July every year?
Output: hemingway days.
Context: The general Chinese history texts on the Ming Dynasty, including the Mingdai Shi and the Mingshi, briefly mention Cao Qin's failed coup of 1461. Cao Qin's coup and the events leading up to it were covered in Gao Dai's Hong you lu of 1573, Jiao Hong's Guochao Xianzheng lu of 1594-1616, the Huang Ming shi gai of 1632 and the Mingshi jishi benmo of 1658. Li Xian also wrote about Cao Jixiang's career in his "Cao Jixiang zhi bian," featured in the Huang Ming mingchen jingji lu that was edited by Huang Xun in 1551. 
 Question: What happened first: Cao Qin's failed coup or Gao Dai's Hong you lu?
Output: cao qin's failed coup
Context: An alloy is a mixture of a metal with one or more other elements. The other elements may be metals, nonmetals, or both. An alloy is formed by melting a metal and dissolving the other elements in it. The molten solution is then allowed to cool and harden. Alloys generally have more useful properties than pure metals. Several examples of alloys are described and pictured below. If you have braces on your teeth, you might even have this alloy in your mouth! Click image to the left or use the URL below. URL: Most metal objects are made of alloys rather than pure metals. Objects made of four different alloys are shown in the Figure 1.1. Brass saxophone: Brass is an alloy of copper and zinc. It is softer than bronze and easier to shape. Its also very shiny. Notice the curved pieces in this shiny brass saxophone. Brass is used for shap- ing many other curved objects, such as doorknobs and plumbing fixtures. Stain- less steel sink: Stainless steel is a type of steel that contains nickel and chromium in addition to carbon and iron. It is shiny, strong, and resistant to rusting. This makes it useful for sinks, eating utensils, and other objects that are exposed to wa- ter. "Gold" bracelet: Pure gold is relatively soft, so it is rarely used for jewelry. Most "gold" jewelry is actually made of an alloy of gold, copper and silver. Bronze statue: Bronze was the first alloy ever made. The earliest bronze dates back many thou- sands of years. Bronze is a mixture of copper and tin. Both copper and tin are relatively soft metals, but mixed together in bronze they are much harder. Bronze has been used for statues, coins, and other objects. Q: Sterling silver is an alloy that is used to make fine jewelry. What elements do you think sterling silver contains? What properties might sterling silver have that make it more useful than pure silver? A: Most sterling silver is about 93 percent silver and about 7 percent copper. Sterling silver is harder and stronger than pure silver, while retaining the malleability and luster of pure silver. 
 Question: the first alloy ever made was
Output: bronze.
Context: Fear plays no part in this latest problem."I'm not afraid I'll lose my children.I won't lose my children. We live together, and nothing, nothing," she repeats, her voice rising when speaking to John's lawyer, "will stop me from being with my children. A law? Yeah, right. Don't disturb me when it comes to my children. You are never going to win. If John wants to see them, I cannot stop him. He's their father--I want them to see him! However, his visit in his present condition will disturb the children's stable life." John, who has spent much of his time in California, recently, has only hired a house for himself in Pennsylvania, according to his lawyer. "If he'd like to stick to a regular life, I'd be more than happy to do that," Jane says. "The best thing for any child of a divorced parent is a stable life. I want nothing more than for him to set up a stable life for himself, so that he can be part of making our children's lives more stable. " While matters of money and care won't be settled for weeks, Jane hardly puts her life on hold. Last week the ABC network announced that Jane would return with her own show, Twist of Jane, in which she gives advice to other moms.Jane and her eight children will also return to ABC in a series of Jane Plus 8 specials showing them on various adventures.It's a rest for Jane, who insists that she needs her new,busy life to provide for her family."I have to lead such a life, and I'm thankful that I've built it to the top where now I can support my children."she says. And whether a bellicose dance judge or a bellicose former wife, Jane plans to keep on facing attacks on her. "Some people try to knock me down--only to make me more fierce,more protective,more determined to do better,"she says."Go ahead, take me on. This will just make me stronger." 
 Question: Which word can best describe Jane?
Output: determined.
Context: After periods with Shamrock Rovers, Shelbourne and University College Dublin A.F.C., O Snodaigh was a squad member of the successful Bray Wanderers side that won the 1989-90 FAI Cup in at Lansdowne Road with a 3-0 victory against St Francis, lost in the European Cup Winners Cup tie against Trabzonspor, and finished runners-up in the 1990-91 League of Ireland First Division. That same year he was a central member of Wanderers reserve side that finished runners-up in the League of Ireland B Division. He won the B team player of the year award in 1990 and was a member of the first team that lost the LFA President's Cup final 3-1 against Dundalk. In time he left Bray and became a member of Leinster Senior League side Pegasus where, over a seven-year period, he was a member of their FAI Intermediate Cup winning team in 1992 against Bluebell United, top scorer in 1996/7, selected for the Leinster Senior League selection team in 1992, was captain of the side that got relegated from the senior division in 1997 following a defeat away to Bluebell and played in every position for the side except goalkeeper. 
 Question: Which team won the European Winners Cup, Trabzonspor or the Bray Wanderers?
Output: trabzonspor
Context: Arnaud Berquin (September 1747 -- 21 December 1791) was a French children's author. 
 Question: What is the language of Arnaud Berquin?
Output: french
Context: Double homeobox 4 (DUX4) is a candidate disease gene for facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophies characterized by progressive skeletal muscle degeneration. Despite great strides in understanding precise genetics of FSHD, the molecular pathophysiology of the disease remains unclear. One of the major limitations has been the availability of appropriate molecular tools to study DUX4 protein. In the present study, we report the development of five new monoclonal antibodies targeted against the N- and C-termini of human DUX4, and characterize their reactivity using Western blot and immunofluorescence staining. Additionally, we show that expression of the canonical full coding DUX4 induces cell death in human primary muscle cells, whereas the expression of a shorter splice form of DUX4 results in no such toxicity. Immunostaining with these new antibodies reveals a differential effect of two DUX4 isoforms on human muscle cells. These antibodies will provide an excellent tool for investigating the role of DUX4 in FSHD pathogenesis. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
Output: fshd
Context: Double homeobox 4 (DUX4) is a candidate disease gene for facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophies characterized by progressive skeletal muscle degeneration. Despite great strides in understanding precise genetics of FSHD, the molecular pathophysiology of the disease remains unclear. One of the major limitations has been the availability of appropriate molecular tools to study DUX4 protein. In the present study, we report the development of five new monoclonal antibodies targeted against the N- and C-termini of human DUX4, and characterize their reactivity using Western blot and immunofluorescence staining. Additionally, we show that expression of the canonical full coding DUX4 induces cell death in human primary muscle cells, whereas the expression of a shorter splice form of DUX4 results in no such toxicity. Immunostaining with these new antibodies reveals a differential effect of two DUX4 isoforms on human muscle cells. These antibodies will provide an excellent tool for investigating the role of DUX4 in FSHD pathogenesis. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
Output: facioscapulohumeral dystrophy
Context: Variant histone H2AZ-containing nucleosomes are involved in the regulation of gene expression. In Saccharomyces cerevisiae, chromatin deposition of histone H2AZ is mediated by the fourteen-subunit SWR1 complex, which catalyzes ATP-dependent exchange of nucleosomal histone H2A for H2AZ. Previous work defined the role of seven SWR1 subunits (Swr1 ATPase, Swc2, Swc3, Arp6, Swc5, Yaf9, and Swc6) in maintaining complex integrity and H2AZ histone replacement activity. Here we examined the function of three additional SWR1 subunits, bromodomain containing Bdf1, actin-related protein Arp4 and Swc7, by analyzing affinity-purified mutant SWR1 complexes. We observed that depletion of Arp4 (arp4-td) substantially impaired the association of Bdf1, Yaf9, and Swc4. In contrast, loss of either Bdf1 or Swc7 had minimal effects on overall complex integrity. Furthermore, the basic H2AZ histone replacement activity of SWR1 in vitro required Arp4, but not Bdf1 or Swc7. Thus, three out of fourteen SWR1 subunits, Bdf1, Swc7, and previously noted Swc3, appear to have roles auxiliary to the basic histone replacement activity. The N-terminal region of the Swr1 ATPase subunit is necessary and sufficient to direct association of Bdf1 and Swc7, as well as Arp4, Act1, Yaf9 and Swc4. This same region contains an additional H2AZ-H2B specific binding site, distinct from the previously identified Swc2 subunit. These findings suggest that one SWR1 enzyme might be capable of binding two H2AZ-H2B dimers, and provide further insight on the hierarchy and interdependency of molecular interactions within the SWR1 complex. 
 Question: Which protein mediates the replacement of H2A by H2A.Z in the yeast Saccharomyces cerevisiae?
Output: swr1
Context: The Caretaker Cabinet of Panagiotis Pikrammenos was sworn in on May 17, 2012 when an inconclusive election on May 6, 2012 resulted in a hung parliament. 
 Question: What year did Caretaker Cabinet of Panagiotis Pikrammenos end?
Output: 2012
Context: Duavee, an oral contraceptive; riociguat (Adempas) for two types of pulmonary hypertension; and macitentan (Opsumit) for pulmonary arterial hypertension. 
 Question: What is generic name of drug Adempas?
Output: riociguat
Context: Restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) are considered to be a continuum of a neurological sleep disorder associated with abnormal iron metabolism or deficiency. I describe a case of RLS and PLMD in a cystic fibrosis patient with iron deficiency from chronic hemoptysis. This is the first case that reports RLS and PLMD manifesting from iron deficiency caused by chronic hemoptysis in advanced cystic fibrosis lung disease. 
 Question: Which deficiency is the cause of restless leg syndrome?
Output: iron
Context: Lake Forest High School Clubs Environmental Club Club members are provided opportunities to realize their goals of environmental service. The majority of projects are student-initiated. Last year's activities included: the LFHS Courtyard Garden upkeep, Bike to School Day with free cocoa and snacks, an "eat local" 100-mile dinner, recycling solutions for LFHS, beach cleanup through the Great Lakes Alliance, and Earth Week celebrations. Meetings: First Friday of the month in Room 5 at 7:00 a.m. Advisor: Ms Mary Beth Nawor, _ Peer Tutoring Students volunteer to help fellow students in improving their academic and organizational skills. Students tutor LFHS and middle school students on an individually scheduled basis. LFHS tutors must have proficiency in the academic area in which they wish to tutor, but middle school tutors only need general academic proficiency. Meetings: All tutoring is done on an individually scheduled basis. Advisor: Ms Kathy O'Hara, _ Young Idea Young Idea is LFHS's art and literary magazine. Students of all ages who love writing and art are encouraged to become part of the staff of this award-winning magazine. Young Idea encourages all students to submit art and literature works to the magazine, whether they are a part of the staff or not. From September to February, Young Idea meets on Thursdays after school in the Public Room to discuss the pieces that have been submitted to the magazine and provide feedback for the authors. Meetings: See above explanation. Advisor: Ms Debbie Zare, _ Scout Buddies Scout Buddies is a friendship club which helps build friendship among individuals with and without disabilities. Club members participate in a variety of social activities both within the school and in the community. Activities include organizing holiday parties in the school, bowling, going to the movies, and eating out in local restaurants. Meetings: Monthly meeting dates vary, but in Room 134. Advisor: Ms Donna Lovitsch, _ 
 Question: Which club provides help for students poor in study?
Output: peer tutoring.
Context: Scientists have been aware for many years of genetic programs that get activated under stress and produce genetic variants in cells that escape non-proliferating conditions. These programs are well conserved in all organisms and expand our view of evolution. They mediate genome instability, create diversity in antibody formation, expand metabolism and increase fitness of pathogens within host environments. Error-prone DNA replication and repair are genetic variability-causing agents that get stimulated by the onset of cellular stresses. Embedded in these programs is the ability to limit mutagenesis to defined genomic regions and times, ensuring integrity of most of the genome. Recent evidence suggests that factors involved in RNA polymerase (RNAP) processivity or transcriptional derepression contribute to the generation of stress-induced mutations. In Bacillus subtilis, transcription-associated mutagenesis has been shown to be independent of recombination-dependent repair and, in some cases, of the Y DNA polymerases. Central to stationary-phase mutagenesis in B. subtilis is the requirement for Mfd, transcription coupling repair factor, which suggests a novel mechanism from those described in other model systems. 
 Question: In which phase of cell cycle does stress-induced transcription-associated mutagenesis (TAM) occur?
Output: stationary-phase
Context: Scientists have been aware for many years of genetic programs that get activated under stress and produce genetic variants in cells that escape non-proliferating conditions. These programs are well conserved in all organisms and expand our view of evolution. They mediate genome instability, create diversity in antibody formation, expand metabolism and increase fitness of pathogens within host environments. Error-prone DNA replication and repair are genetic variability-causing agents that get stimulated by the onset of cellular stresses. Embedded in these programs is the ability to limit mutagenesis to defined genomic regions and times, ensuring integrity of most of the genome. Recent evidence suggests that factors involved in RNA polymerase (RNAP) processivity or transcriptional derepression contribute to the generation of stress-induced mutations. In Bacillus subtilis, transcription-associated mutagenesis has been shown to be independent of recombination-dependent repair and, in some cases, of the Y DNA polymerases. Central to stationary-phase mutagenesis in B. subtilis is the requirement for Mfd, transcription coupling repair factor, which suggests a novel mechanism from those described in other model systems. 
 Question: In which phase of cell cycle does stress-induced transcription-associated mutagenesis (TAM) occur?
Output: stationary phase