niryuu/sni-each-converted huggingface dataset:
Context: Marino finished the game with 29 out of 50 pass completions for 318 yards, 1 touchdown, and 2 interceptions. Clayton was the top receiver of the game, with 6 receptions for 92 yards. Walker returned 4 kickoffs for 93 yards and gained 15 yards on 2 punt returns. Nathan was the Dolphins leading rusher with 18 yards, while also catching 10 passes for 83 yards. Craig had 58 rushing yards, 77 receiving yards, and 3 touchdowns. He was the first player ever to score 3 touchdowns in a Super Bowl, and his 2 touchdown catches also tied a Super Bowl record. Tyler led San Francisco in rushing with 65 yards, and also caught 4 passes for 70 yards. Clark caught 6 passes for 77 yards. Board recorded 2 sacks. McLemore recorded 51 punt return yards, the second most in Super Bowl history. Sports Illustrated called 49ers defensive tackle Gary Johnson (American football) the Super Bowls "unofficial defensive MVP" after he recorded one sack, flushed Marino out of the passing pocket numerous times, and had four unassisted tackles. 
 Question: Who had a higher average of yards per caught pass, Tyler or Clark?
Output: tyler
Context: The U.S. Census for 2010 reported 332,199 households in Indianapolis, with an average household size of 2.42 and an average family size of 3.08. Of the total households, 59.3% were family households, with 28.2% of these including the familys own children under the age of 18; 36.5% were husband-wife families; 17.2% had a female householder (with no husband present) and 5.6% had a male householder (with no wife present). The remaining 40.7% were non-family households. , 32% of the non-family households included individuals living alone, 8.3% of these households included individuals age 65 years of age or older. 
 Question: Which group from the census is larger: family households or husband-wife families?
Output: family households
Context: Secretory phospholipase A2 (sPLA2), which links surfactant catabolism and lung inflammation, is associated with lung stiffness, surfactant dysfunction, and degree of respiratory support in acute respiratory distress syndrome and in some forms of neonatal lung injury. Varespladib potently inhibits sPLA2 in animal models. The authors investigate varespladib ex vivo efficacy in different forms of neonatal lung injury. Bronchoalveolar lavage fluid was obtained from 40 neonates affected by hyaline membrane disease, infections, or meconium aspiration and divided in 4 aliquots added with increasing varespladib or saline. sPLA2 activity, proteins, and albumin were measured. Dilution was corrected with the urea ratio. Varespladib was also tested in vitro against pancreatic sPLA2 mixed with different albumin concentration. Varespladib was able to inhibit sPLA2 in the types of neonatal lung injury investigated. sPLA2 activity was reduced in hyaline membrane disease (P < .0001), infections (P = .003), and meconium aspiration (P = .04) using 40 M varespladib; 10 M was able to lower enzyme activity (P = .001), with an IC(50) of 87 M. An inverse relationship existed between protein level and activity reduction (r = 0.5; P = .029). The activity reduction/protein ratio tended to be higher in hyaline membrane disease. Varespladib efficacy was higher in vitro than in lavage fluids obtained from neonates (P < .001). 
 Question: Which enzyme is inhibited by Varespladib?
Output: secretory phospholipase a2
Context: In the county, the population was spread out with 23.20% under the age of 18, 7.70% from 18 to 24, 27.00% from 25 to 44, 28.00% from 45 to 64, and 14.10% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 97.00 males. For every 100 females age 18 and over, there were 96.40 males. 
 Question: Which age group had the least people?
Output: 18 to 24
Context: Nearly everyone is shy in some ways. If shyness is making you uncomfortable, it may be time for a few lessons in self-confidence. You can build your confidence by following some suggestions from doctors and psychologists. Make a decision not to hold back in conversations. What you have to say is just as important as what other people say. And don't turn down party invitations just because of your shyness. Prepare for yourself for being with others in groups. Make a list of the good qualities you have. Then make a list of ideas, experiences, and skills you would like to share with other people . I think about what you would like to say in advance. Then say it. If you start feeling self-conscious in a group, take a deep breath and focus your attention on other people, Remember, you are not alone. Other people are concerned about the impression they are making, too. No one ever gets over being shy completely, but most people do learn to live with their shyness. Even entertainers admit that they often feel shy. They work at fighting their shy feelings so that they can face the cameras and the public. Just making the effort to control shyness can have many rewards. But perhaps the best reason to fight shyness is to give other people a chance to know about you. 
 Question: Who probably gives the suggestion for fighting shyness?
Output: doctors and psychologists
Context: ''Insane in the Mainframe'' is the twelfthth episode in the third season of the American animated sitcom Futurama. 
 Question: What series is Insane in the Mainframe from?
Output: futurama
Context: Malformation of cortical development (MCD) is a well-known cause of drug-resistant epilepsy and focal cortical dysplasia (FCD) is the most common neuropathological finding in surgical specimens from drug-resistant epilepsy patients. Palmini's classification proposed in 2004 is now widely used to categorize FCD. Recently, however, Blumcke et al. recommended a new system for classifying FCD in 2011. We applied the new classification system in practical diagnosis of a sample of 117 patients who underwent neurosurgical operations due to drug-resistant epilepsy at Severance Hospital in Seoul, Korea. Among 117 cases, a total of 16 cases were shifted to other FCD subtypes under the new classification system. Five cases were reclassified to type IIIa and five cases were categorized as dual pathology. The other six cases were changed within the type I category. The most remarkable changes in the new classification system are the advent of dual pathology and FCD type III. Thus, it will be very important for pathologists and clinicians to discriminate between these new categories. More large-scale research needs to be conducted to elucidate the clinical influence of the alterations within the classification of type I disease. Although the new FCD classification system has several advantages compared to the former, the correlation with clinical characteristics is not yet clear. 
 Question: Which disorder is rated by Palmini classification?
Output: focal cortical dysplasia
Context: Kong Zi , also called Confucius (551-479 B.C) , and Socrates (469-399 B. C) lived only a hundred years apart , and during their lifetimes there was no contact between China and Greece, but it is interesting to look at how the world that each of these great philosophers came from shaped their ideas , and how these ideas in turn ,shaped their societies. Confucius suggested the Golden Rule as a principle for the conduct of life:" Do not do to others what you would not want others to do to you." He assumed that all men were equal at birth, though some bad more potential than others, and that it was knowledge that set men apart. Socrates focused on the individual, and thought that the greatest purpose of man was to seek wisdom. He believed that the superior class should rule the inferior classes. For Socrates, the family was of no importance, and the community of little concern. For Confucius, however, the family was the centre of the society, with family relations considered much more important than political relations. Both men are respected much more today than they were in their lifetimes. 
 Question: What made some people different from others according to Confucius?
Output: knowledge.
Context: Greenwich is on the River, five miles from the middle of London, and its history is two thousand years old. The first English people were fishermen there, and they named the place Greenwich, meaning "green village". Later the English kings and queens lived at Greenwich in their beautiful places. The name of the earliest palace was Placentia. Henry VIII lived there. He knew that England must be strong at sea. So he started two big ship-yards at Greenwich. But trouble was coming to Greenwich. In 1649, a war started in England and for eleven years there was no king. The men who had worked for him at Placentia decided to live the place themselves. They sold all its beautiful things. Finally, the war ended and King Charles II came back. But Placentia was falling down. So King Charles built a new and bigger palace, which is now open to the public. At this time, Charles was worried about losing so many of its ships at sea: their sailors did not know how to tell exactly where they were. So in 1675, Charles made John Flamsteed, the first astronomer in England, try to find the answer. Flamsteed worked in a new building on the high ground in Greenwich Park. From it with a telescope which he made himself, Flamsteed could look all round the sky. And he did, night after night, for twenty years. Carrying on Flamsteed's work a hundred years later, an astronomer called Harrison finally made a clock which told the time at sea, and helped sailors to know where they were. You can see Harrison's clock, still working, in Greenwich's museum of the sea. Because of Flamsteed's work, every country in the world now tells its time by Greenwich Time. 
 Question: Who made the first clock which could tell the time at sea?
Output: harrison
Context: This article needs an improved plot summary. (November 2015) Sidhu (Akshay Kumar) is a lowly vegetable cutter at a roadside food stall in the Chandni Chowk section of Delhi, who consults astrologers, tarot card readers, and fake fakirs despite his foster father Dada's (Mithun Chakraborty) exhortations. When two strangers from China claim him as a reincarnation of war hero 'Liu Shen' and take him to China, Sidhu, encouraged by trickster Chopstick (Ranvir Shorey), believes he will be feted as a hero, unaware of his own recruitment to assassinate the smuggler Hojo (Gordon Liu). Sidhu travels to China with Chopstick. Along the way he meets Sakhi (Deepika Padukone), the Indian-Chinese spokesmodel known as Ms. Tele Shoppers Media, or Ms. TSM, who also appears in China. Her twin sister Suzy, known as the femme fatale Meow Meow, works for Hojo, not knowing Hojo tried to kill her father, Inspector Chiang (Roger Yuan). Sidhu, through a series of accidents, initially eludes Hojo, but Hojo eventually exposes him as a fraud. Thereupon Hojo kills Dada, and Sidhu is beaten and urinated on by Hojo. Injured and disgraced Sidhu vows revenge. He thereafter encounters an amnesiac vagrant, whom he later identifies to Sakhi as Inspector Chiang. Chiang later recovers his memory and trains Sidhu in kung fu. When Hojo again meets with Sidhu, Suzy injures Chiang; but upon seeing Sakhi, betrays Hojo. Sidhu fights Hojo in single combat, eventually using a modified vegetable-cutting technique to overwhelm him. In the aftermath, Sidhu opens a vegetable stall in China, but is recruited to fight for some African pygmies. The film thereupon concludes with the announcement "To be Continued Chandni Chowk to Africa". 
 Question: What did Hojo reveal Sihu to be?
Output: a fraud
Context: The film explores adolescent issues through the minds of three friends and their reactions after a boy named Rudy Carges (Conor Donovan) is killed in a tree house set on fire by local bullies Jeff and Kenny, who carelessly didn't find out he was inside until too late. The boy's twin brother Jacob, a boy with a huge birthmark (also played by Donovan), decides to seek revenge against the bullies. Leonard (Jesse Camacho) who's overweight, survives the tree house fire but loses his sense of taste and smell. Thanks to the fire, this prompts Leonard to go on a diet, which isn't welcomed by his obese family. The boys' female friend Malee (Zoe Weizenbaum) tries to befriend an adult named Gus (Jeremy Renner), a grief-stricken patient of her therapist mother, Carla (Annabella Sciorra). Jacob's family falls apart after the death of his brother. But shortly after, his parents adopt a boy named Keith Gardner. Meanwhile, Malee begins to have a crush on Gus and changes the song for her recital to one Gus liked, just for him. As time goes by, she sees Gus as her "soul mate". She sneaks into his house one night to find him grieving. Afraid to confront him, Malee steals his gun and leaves. She gives it to Jacob the following day. Jacob frequently visits Jeff and Kenny, who are serving time in a juvenile hall. Jacob initially threatens them, until eventually Jeff commits suicide. Jacob befriends Kenny, soon learning he has an early release and is illegally moving to New Mexico. Meanwhile, Leonard's father decides to take his sisters to Florida instead of Leonard (who would usually go). Leonard decides to force his mother to lose weight by trapping her in the cellar. They both end up in the hospital after a gas leak in their home. Next, Jacob and Kenny agree that Jacob can go with him to New Mexico. Malee visits Gus and removes her clothes in an attempt to seduce him. Instead, Gus calls Malee's mother to come and pick her up. The next day, Gus explains to therapist Carla about the last fire he ever fought (which involved killing an injured little girl, upon the girl's request), claiming that Malee wanted him to take her pain away, as he was aware of her growing crush on him. Meanwhile, Jacob's mother tells him that Keith Gardner wasn't adopted to replace Rudy, and that she wants Kenny dead, which reminds Jacob of his planned revenge. The night of escape for Jacob finally comes and he meets up with Kenny. Jacob insists on going through a construction site which he says is a secret route. Once there, Jacob points Gus's gun at Kenny, and tells him "you killed him" before shooting him dead. Jacob buries the body and leaves. He returns in the daytime, and sees Gus spreading cement above Kenny's grave. Malee begins visiting her estranged father and Leonard's family finally starts eating healthily. The movie ends with Jacob's mother smiling at him from inside the house. 
 Question: Rudy and Jacob are very different?
Output: huge birthmark
Context: Coming off their home win over the Rams, the Bengals flew to Bill Walsh Field at Monster Park for a Saturday night interconference duel with the San Francisco 49ers. After a scoreless first quarter, Cincinnati trailed early in the second quarter as 49ers QB Shaun Hill got a 3-yard TD run. Afterwards, the Bengals would take the lead as kicker Shayne Graham managed to get a 24-yard field goal, while QB Carson Palmer completed a 52-yard TD pass to WR Chris Henry. San Francisco would end the half with Hill completing a 17-yard TD pass to TE Vernon Davis. In the third quarter, the 49ers increased their lead with kicker Joe Nedney getting a 29-yard and a 38-yard field goal. In the fourth quarter, Cincinnati tried to respond as Graham kicked a 35-yard field goal. However, the 49ers' defense held on for the win. With the loss, the Bengals fell to 5-9, securing Head Coach Marvin Lewis' first losing season with Cincinnati. 
 Question: Which team made the last score in the first half?
Output: san francisco
Context: The Reichswehr (English: Empire Defence) formed the military organization of Germany from 1919 until 1935, when it was united with the newly founded Wehrmacht (''Defence Force''). 
 Question: Which year did Reichswehr end?
Output: 1935
Context: The median income for a household in the city in 2000 was $29,378 (2010$37,436), and the median income for a family was $41,158. Males had a median income of $32,929 versus $26,856 for females. The per capita income for the city was $17,076. About 20.2% of families and 25.9% of the population were below the poverty line, including 41.5% of those under age 18 and 5.6% of those age 65 or over. 
 Question: What group of people made up the largest percentage of those below the poverty line?
Output: under age 18
Context: On 26 March 1991, Singapore Airlines Flight 117 was hijacked in flight by four male passengers from Pakistan. 
 Question: When did Singapore Airlines Flight 117 occur?
Output: 26 march 1991
Context: Neurofibromatosis type 1 is one of the most common autosomal dominant disorders, affecting about 1:3,500 individuals. NF1 exon 7 displays weakly defined exon-intron boundaries, and is particularly prone to missplicing. In this study we investigated the expression of exon 7 transcripts using bioinformatic identification of splicing regulatory sequences, and functional minigene analysis of four sequence changes [c.910C>T (R304X), c.945G>A/c.946C>A (Q315Q/L316M), c.1005T>C (N335N)] identified in exon 7 of three different NF1 patients. Our results detected the presence of three exonic splicing enhancers (ESEs) and one putative exonic splicing silencer (ESS) element. The wild type minigene assay resulted in three alternative isoforms, including a transcript lacking NF1 exon 7 (NF1DeltaE7). Both the wild type and the mutated constructs shared NF1DeltaE7 in addition to the complete messenger, but displayed a different ratio between the two transcripts. In the presence of R304X and Q315Q/L316M mutations, the relative proportion between the different isoforms is shifted toward the expression of NF1DeltaE7, while in the presence of N335N variant, the NF1DeltaE7 expression is abolished. In conclusion, it appears mandatory to investigate the role of each nucleotide change within the NF1 coding sequence, since a significant proportion of NF1 exon 7 mutations affects pre-mRNA splicing, by disrupting exonic splicing motifs and modifying the delicate balance between aberrantly and correctly spliced transcripts. 
 Question: Which is the gene mutated in type 1 neurofibromatosis?
Output: nf1
Context: Selenocysteine (Sec) is co-translationally incorporated into selenoproteins at a reprogrammed UGA codon. In mammals, this requires a dedicated machinery comprising a stem-loop structure in the 3' UTR RNA (the SECIS element) and the specific SECIS Binding Protein 2. In this report, disorder-prediction methods and several biophysical techniques showed that ca. 70% of the SBP2 sequence is disordered, whereas the RNA binding domain appears to be folded and functional. These results are consistent with a recent report on the role of the Hsp90 chaperone for the folding of SBP2 and other functionally unrelated proteins bearing an RNA binding domain homologous to SBP2. 
 Question: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Output: secis
Context: If the outside environment of a cell is water-based, and the inside of the cell is also mostly water, something has to make sure the cell stays intact in this environment. What would happen if a cell dissolved in water, like sugar does? Obviously, the cell could not survive in such an environment. So something must protect the cell and allow it to survive in its water-based environment. All cells have a barrier around them that separates them from the environment and from other cells. This barrier is called the plasma membrane, or cell membrane. The plasma membrane ( Figure 1.1) is made of a double layer of special lipids, known as phospholipids. The phospholipid is a lipid molecule with a hydrophilic ("water-loving") head and two hydrophobic ("water-hating") tails. Because of the hydrophilic and hydrophobic nature of the phospholipid, the molecule must be arranged in a specific pattern as only certain parts of the molecule can physically be in contact with water. Remember that there is water outside the cell, and the cytoplasm inside the cell is mostly water as well. So the phospholipids are arranged in a double layer (a bilayer) to keep the cell separate from its environment. Lipids do not mix with water (recall that oil is a lipid), so the phospholipid bilayer of the cell membrane acts as a barrier, keeping water out of the cell, and keeping the cytoplasm inside the cell. The cell membrane allows the cell to stay structurally intact in its water-based environment. The function of the plasma membrane is to control what goes in and out of the cell. Some molecules can go through the cell membrane to enter and leave the cell, but some cannot. The cell is therefore not completely permeable. "Permeable" means that anything can cross a barrier. An open door is completely permeable to anything that wants to enter or exit through the door. The plasma membrane is semipermeable, meaning that some things can enter the cell, and some things cannot. The inside of all cells also contain a jelly-like substance called cytosol. Cytosol is composed of water and other molecules, including enzymes, which are proteins that speed up the cells chemical reactions. Everything in the cell sits in the cytosol, like fruit in a jello mold. The term cytoplasm refers to the cytosol and all of the organelles, the specialized compartments of the cell. The cytoplasm does not include the nucleus. As a prokaryotic cell does not have a nucleus, the DNA is in the cytoplasm. 
 Question: the middle of the cell membrane bilayer is an area without __________.
Output: water
Context: Imatinib was developed as the first molecularly targeted therapy to specifically inhibit the BCR-ABL kinase in Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML). Because of the excellent hematologic and cytogenetic responses, imatinib has moved toward first-line treatment for newly diagnosed CML. However, the emergence of resistance to imatinib remains a major problem in the treatment of Ph-positive leukemia. Several mechanisms of imatinib resistance have been identified, including BCR-ABL gene amplification that leads to overexpression of the BCR-ABL protein, point mutations in the BCR-ABL kinase domain that interfere with imatinib binding, and point mutations outside of the kinase domain that allosterically inhibit imatinib binding to BCR-ABL. The need for alternative or additional treatment for imatinib-resistant BCR-ABL-positive leukemia has guided the way to the design of a second generation of targeted therapies, which has resulted mainly in the development of novel small-molecule inhibitors such as AMN107, dasatinib, NS-187, and ON012380. The major goal of these efforts is to create new compounds that are more potent than imatinib and/or more effective against imatinib-resistant BCR-ABL clones. In this review, we discuss the next generation of BCR-ABL kinase inhibitors for overcoming imatinib resistance. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Marino finished the game with 29 out of 50 pass completions for 318 yards, 1 touchdown, and 2 interceptions. Clayton was the top receiver of the game, with 6 receptions for 92 yards. Walker returned 4 kickoffs for 93 yards and gained 15 yards on 2 punt returns. Nathan was the Dolphins leading rusher with 18 yards, while also catching 10 passes for 83 yards. Craig had 58 rushing yards, 77 receiving yards, and 3 touchdowns. He was the first player ever to score 3 touchdowns in a Super Bowl, and his 2 touchdown catches also tied a Super Bowl record. Tyler led San Francisco in rushing with 65 yards, and also caught 4 passes for 70 yards. Clark caught 6 passes for 77 yards. Board recorded 2 sacks. McLemore recorded 51 punt return yards, the second most in Super Bowl history. Sports Illustrated called 49ers defensive tackle Gary Johnson (American football) the Super Bowls "unofficial defensive MVP" after he recorded one sack, flushed Marino out of the passing pocket numerous times, and had four unassisted tackles. 
 Question: Did Marino have more touchdowns or interceptions?
Output: interceptions
Context: Organisms are individual living things. They range from microscopic bacteria to gigantic blue whales (see Figure must be obtained from the environment. Biotic factors are all of the living or once-living aspects of the environment. They include all the organisms that live there as well as the remains of dead organisms. Abiotic factors are all of the aspects of the environment that have never been alive. They include factors such as sunlight, minerals in soil, temperature, and moisture. Ecologists study organisms and environments at several different levels, from the individual to the biosphere. The levels are depicted in Figure 23.2 and described below. For a video introduction to the levels of organization in ecology, click on this link: . MEDIA Click image to the left or use the URL below. URL: An individual is an organism, or single living thing. A population is a group of individuals of the same species that live in the same area. Members of the same population generally interact with each other. A community is made up of all the populations of all the species that live in the same area. Populations in a community also generally interact with each other. 
 Question: __group of individuals of the same species that live in the same area
Output: population
Context: According to 2011 census of India, Kumbakonam had a population of 140,156 with a sex-ratio of 1,021 females for every 1,000 males, much above the national average of 929. A total of 12,791 were under the age of six, constituting 6,495 males and 6,296 females.The average literacy of the city was 83.21%, compared to the national average of 72.99%. There were a total of 9,519 workers, comprising 32 cultivators, 83 main agricultural labourers, 1,206 in house hold industries, 7,169 other workers, 1,029 marginal workers, 24 marginal cultivators, 45 marginal agricultural labourers, 212 marginal workers in household industries and 0 other marginal workers. 
 Question: Which group of workers is smaller: in house hold industries or main agricultural labourers?
Output: main agricultural labourers
Context: Rotterdam Centrum is bounded by the emplacement of the Rotterdam Centraal railway station and the Goudsesingel in the North, the Tunneltraverse of the Henegouwerlaan and 's-Gravendijkwal in the West, the Nieuwe Maas River in the South and the Oostplein in the East. 
 Question: Which is the body of water by Rotterdam Centrum?
Output: nieuwe maas
Context: Chronic myeloid leukemia cells contain a BCR-ABL oncoprotein with an enhanced tyrosine kinase activity, which is considered to be the principal 'cause' of the leukemia. Though the precise mechanisms underlying the leukemogenesis remains enigmatic, the use of imatinib to inhibit the dysregulated kinase activity has proved remarkably successful in clinical practice. Imatinib was the first small molecule developed to inhibit BCR-ABL tyrosine kinase activity and its success introduced the current era of molecularly targeted therapies for a number of other malignancies. In patients with chronic myeloid leukaemia who develop resistance to imatinib, the Bcr-Abl signaling pathway is often re-established. This has led to the emergence of a number of alternative treatment strategies designed to target the leukemic cell which are resistant to imatinib. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Quinton Spears (born May 11, 1988) is an American football linebacker of the National Football League (NFL), who is currently a free agent. 
 Question: Which sport does Quinton Spears practice?
Output: american football
Context: On November 13, 1982, 15-year-old Scott Safran of Cherry Hill, New Jersey, set a world record of 41,336,440 points on the arcade game Asteroids, beating the 40,101,910 point score set by Leo Daniels of Carolina Beach on February 6, 1982. In 1998, to congratulate Safran on his accomplishment, the Twin Galaxies Intergalactic Scoreboard searched for him for four years until 2002, when it was discovered that he had died in an accident in 1989. In a ceremony in Philadelphia on April 27, 2002, Walter Day of Twin Galaxies presented an award to the surviving members of Safrans family, commemorating the Asteroid Champions achievement. On April 5, 2010, John McAllister broke Safrans record with a high score of 41,838,740 in a 58-hour Internet livestream. 
 Question: Which player was third in their highest score playing Asteroids, Daniels, Mc Allister or Safran?
Output: mcallister
Context: Intensive short-term dynamic psychotherapy (ISTDP) is a form of short-term psychotherapy developed through empirical, video-recorded research by Habib Davanloo, MD. 
 Question: Which developer released Intensive short-term dynamic psychotherapy?
Output: habib davanloo
Context: Denosumab is a human monoclonal antibody which specifically blocks receptor activator of nuclear factor B ligand and is a very potent antiresorptive drug. Its efficacy in reducing the risk of vertebral, hip and nonskeletal fracture has been proven in a large prospective, randomized multicenter study of 7808 postmenopausal women with osteoporosis [Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) trial]. Denosumab causes somewhat greater increases in bone mineral density (BMD) than the class of bisphosphonate antiresorptives. Denosumab also causes an increase in bone mass and bone strength in the spine, ultradistal and diaphysis of the radius, proximal tibia and the hip. Recently long-term treatment with denosumab has been shown to cause a continued almost linear increase in total hip and femoral neck BMD beyond 3 years up to 8 years. In this respect, denosumab seems to differ from the bisphosphonate group in which the rate of improvement of BMD diminishes and for some drugs becomes negative after 3-4 years when the process of secondary mineralization flattens out. This unique property of an antiresorptive drug points towards mechanisms of action which differ from the bisphosphonate group. Both types of antiresorptives decrease cortical porosity but contrary to bisphosphonates the reduction in cortical porosity continues with denosumab which, in addition, also seems to cause a slight continuous modeling-based formation of new bone despite suppression of bone remodeling. The net effect is an increase in cortical thickening and bone mass, and increased strength of cortical bone. This may contribute substantially to the significant further reduction of the nonvertebral fracture risk which was found in the long-term denosumab arm of the FREEDOM extension trial during years 4-7. 
 Question: Which is the target of the drug Denosumab?
Output: receptor activator of nuclear factor κb ligand
Context: Denosumab is a human monoclonal antibody which specifically blocks receptor activator of nuclear factor B ligand and is a very potent antiresorptive drug. Its efficacy in reducing the risk of vertebral, hip and nonskeletal fracture has been proven in a large prospective, randomized multicenter study of 7808 postmenopausal women with osteoporosis [Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) trial]. Denosumab causes somewhat greater increases in bone mineral density (BMD) than the class of bisphosphonate antiresorptives. Denosumab also causes an increase in bone mass and bone strength in the spine, ultradistal and diaphysis of the radius, proximal tibia and the hip. Recently long-term treatment with denosumab has been shown to cause a continued almost linear increase in total hip and femoral neck BMD beyond 3 years up to 8 years. In this respect, denosumab seems to differ from the bisphosphonate group in which the rate of improvement of BMD diminishes and for some drugs becomes negative after 3-4 years when the process of secondary mineralization flattens out. This unique property of an antiresorptive drug points towards mechanisms of action which differ from the bisphosphonate group. Both types of antiresorptives decrease cortical porosity but contrary to bisphosphonates the reduction in cortical porosity continues with denosumab which, in addition, also seems to cause a slight continuous modeling-based formation of new bone despite suppression of bone remodeling. The net effect is an increase in cortical thickening and bone mass, and increased strength of cortical bone. This may contribute substantially to the significant further reduction of the nonvertebral fracture risk which was found in the long-term denosumab arm of the FREEDOM extension trial during years 4-7. 
 Question: Which is the target of the drug Denosumab?
Output: receptor activator of nuclear factor-κb ligand
Context: Denosumab is a human monoclonal antibody which specifically blocks receptor activator of nuclear factor B ligand and is a very potent antiresorptive drug. Its efficacy in reducing the risk of vertebral, hip and nonskeletal fracture has been proven in a large prospective, randomized multicenter study of 7808 postmenopausal women with osteoporosis [Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) trial]. Denosumab causes somewhat greater increases in bone mineral density (BMD) than the class of bisphosphonate antiresorptives. Denosumab also causes an increase in bone mass and bone strength in the spine, ultradistal and diaphysis of the radius, proximal tibia and the hip. Recently long-term treatment with denosumab has been shown to cause a continued almost linear increase in total hip and femoral neck BMD beyond 3 years up to 8 years. In this respect, denosumab seems to differ from the bisphosphonate group in which the rate of improvement of BMD diminishes and for some drugs becomes negative after 3-4 years when the process of secondary mineralization flattens out. This unique property of an antiresorptive drug points towards mechanisms of action which differ from the bisphosphonate group. Both types of antiresorptives decrease cortical porosity but contrary to bisphosphonates the reduction in cortical porosity continues with denosumab which, in addition, also seems to cause a slight continuous modeling-based formation of new bone despite suppression of bone remodeling. The net effect is an increase in cortical thickening and bone mass, and increased strength of cortical bone. This may contribute substantially to the significant further reduction of the nonvertebral fracture risk which was found in the long-term denosumab arm of the FREEDOM extension trial during years 4-7. 
 Question: Which is the target of the drug Denosumab?
Output: rankl
Context: Still looking for their first win of the season, the Titans flew to Gillette Stadium, donned Oilers throwback uniforms, and played a Week 6 AFL Legacy game with the New England Patriots in a rare October snowstorm. Tennessee's struggles continued as Patriots running back Laurence Maroney got a 45-yard touchdown run, followed by kicker Stephen Gostkowski making a 33-yard field goal. Things got worse for the Titans in the second quarter as quarterback Tom Brady completed five touchdown passes, two to wide receiver Randy Moss (40-yard and 28-yard), one to running back Kevin Faulk (38-yard), and two to wide receiver Wes Welker (30-yard and 5-yard). The Patriots' 45-0 halftime lead was the largest in NFL history. New England would then conclude their scoring in the third quarter with Brady's 9-yard touchdown pass to Moss, followed by backup quarterback Brian Hoyer's one-yard touchdown run. With the loss, not only did the Titans go into the bye week at 0-6 (their first such start since 1984), but they suffered their worst loss in franchise history, eclipsing a 61-7 loss to Cincinnati in 1989, when the team was the Houston Oilers. This was the first 59-0 game since 1976, and only the fourth in NFL history. It was the largest blowout in the 2009 season, and tied the post-merger record for largest margin of victory. 
 Question: Who scored a touchdown run first, Laurence Maroney or Brian Hoyer?
Output: laurence maroney
Context: The Peasant revolt in Flanders 1323-1328 was a popular revolt in late medieval Europe. Beginning as a series of scattered rural riots in late 1323, peasant insurrection escalated into a full-scale rebellion that dominated public affairs in Flanders for nearly five years until 1328. The uprising in Flanders was caused by both excessive taxations levied by the Count of Flanders Louis I, and by his pro-French policies. The insurrection had urban leaders and rural factions which took over most of Flanders by 1325. The revolt was led by Nicolaas Zannekin, a rich farmer from Lampernisse. Zannekin and his men captured the towns of Nieuwpoort, Veurne, Ypres and Kortrijk. In Kortrijk, Zannekin was able to capture the count himself. In 1325, attempts to capture Gent and Oudenaarde failed. The King of France, Charles IV intervened, whereupon Louis was released from captivity in February 1326 and the Peace of Arques was sealed. The peace soon failed, and the count fled to France when more hostilities erupted. Louis convinced his new liege Philip VI of France to come to his aid, and Zannekin and his adherents were decisively defeated by the French royal army in the Battle of Cassel. 
 Question: What happened first: Louis was released or Peace of Arques was sealed?
Output: louis was released
Context: Padua stands on the Bacchiglione River, 40 kilometres (25 miles) west of Venice and 29 km (18 miles) southeast of Vicenza. 
 Question: Which is the body of water by Padua?
Output: bacchiglione
Context: Angels Online or Angel Love Online (ALO; simplified Chinese: ; traditional Chinese: ; pinyin: Tianshi Zhi Lian) is a free-to-play PC and PlayStation 3 2D massively multiplayer online role-playing game developed by UserJoy Technology in Taiwan, and published by Q Entertainment. 
 Question: Who produced or published Angels Online?
Output: q entertainment
Context: Pasta is the world's favorite food. Asurveytaken in 17 countriesconfirmedthat pasta is what people like to eat most. Not only is pasta the number one food in its home country -Italy, but is alsoenjoyedin faraway places like the Philippines, Mexico andSouth Africa. Pasta has become popular, for one thing, because it is cheap and easy to prepare. Just cook noodles or other forms of pasta, make a sauce to go with it and you're finished. Many different types of meals can becreatedwith pasta. It tastes good and fills your stomach. It produces energy in the form ofcarbohydrates , which is whyathleteseat pasta regularly. Pasta can also be kept for a longer time. You don't have to use it up at once. Pasta has also become popular because it stands for the Italian way of life. People all over the world like it because it's so simple. It has two basic ingredients , wheatand water, just like bread. Legend has itthat Marco Polo brought pasta back to Italy with him but this is not true. Arabs probably brought a noodle-likedishtoSicilyin the 8th century. Farmers have been growing wheat, the mainingredientof pasta, there for ages. The worldwide sales of pasta have risen sharply over the past decade. Italy leads the pasta-eatingcommunityof the world. The Italians are the number one consumers followed by Venezuela and Tunisia. 
 Question: In which country do people eat pasta most?
Output: venezuela
Context: Christian Chalmin, publisher, born in 1947 at Autry-Issards and Mayor of the commune from 1989 to 1995. 
 Question: Which person was the head of government of Autry-Issards?
Output: christian chalmin
Context: The first year after birth is called infancy. Infancy is a period when the baby grows very fast. During infancy, the baby doubles in length and triples in weight. Other important changes also happen during infancy: The babys teeth start to come in, usually at about six months of age ( Figure 1.1). The baby starts smiling, paying attention to other people, and grabbing toys. The baby begins making babbling sounds. By the end of the first year, the baby is starting to say a few words, such as mama and dada. The baby learns to sit, crawl, and stand. By the end of the first year, the baby may be starting to walk. Childhood begins after the babys first birthday and continues until the teen years. Between one and three years of age, a child is called a toddler. During the toddler stage, growth is still fast, but not as fast as it was during infancy. A toddler learns many new words. The child even starts putting together words in simple sentences. Motor skills also develop quickly during this stage. By age three, most children can run and climb steps. They can hold crayons and scribble with them. They can also feed themselves and use the toilet. From age three until the teens, growth is slower. The body also changes shape. The arms and legs get longer compared to the trunk. Children continue to develop new motor skills. For example, many young children learn how to ride a tricycle and then a bicycle. Most also learn how to play games and sports ( Figure 1.2). By age six, children start losing their baby teeth. Their permanent teeth begin coming in to replace them. They also start school and learn how to read and write. They develop friendships and become less dependent on their parents. There are numerous milestones that occur during the first few years of childhood. These include the use of language, walking and running, understanding simple concepts, pretend play, the development of fine motor skills, the development of independence, Children develop better motor skills as they get older. having temper tantrums, demonstrating separation anxiety, becoming fully potty-trained, showing natural curiosity. 
 Question: during infancy, a baby
Output: doubles in length and triples in weight.
Context: 521 Brixia is a minor planet orbiting the Sun that was discovered by American astronomer Raymond Smith Dugan on January 10, 1904. 
 Question: The inventor of 521 Brixia was whom?
Output: raymond smith dugan
Context: A mutation in the ubiquilin 2 gene (UBQLN2) was recently identified as a cause of X-linked amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and a major component of the inclusion bodies commonly found with a wide variety of ALS. ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system. However, the molecular properties of mutant UBQLN2 remain unclear. To gain insight into the pathogenesis of UBQLN2-linked ALS/FTD, we examined the biochemical and cellular characteristics of mutant UBQLN2 in vitro. UBQLN2 localized in Rab11-positive endosomal vesicles formed by the ALS-linked molecule optineurin (OPTN). These vesicles were ubiquitin- and p62-immunopositive and also co-localized with an initiator of the autophagic process, ULK1, after amino acid starvation. An ALS-linked mutation (E478G) in OPTN abolished vesicle formation. ALS-linked mutations in UBQLN2 additively enhanced UBQLN2 aggregation and formation of inclusion bodies, resulting in mislocation from OPTN vesicles. UBQLN2 was found to be a potent regulator of the levels of the FTD-linked secretory factor progranulin, possibly via the endosomal system, and ALS-linked mutations disturbed these functional consequences. This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. These data suggest a novel disease spectrum and provide new pathological insights into OPTN and UBQLN2, enhancing our understanding of the molecular basis of ALS/FTD. 
 Question: Which human disease is associated with mutated UBQLN2
Output: amyotrophic lateral sclerosis
Context: A mutation in the ubiquilin 2 gene (UBQLN2) was recently identified as a cause of X-linked amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and a major component of the inclusion bodies commonly found with a wide variety of ALS. ALS-linked mutations in UBQLN2 are clustered in a unique proline-X-X repeat region, reportedly leading to impairment of the ubiquitin proteasome system. However, the molecular properties of mutant UBQLN2 remain unclear. To gain insight into the pathogenesis of UBQLN2-linked ALS/FTD, we examined the biochemical and cellular characteristics of mutant UBQLN2 in vitro. UBQLN2 localized in Rab11-positive endosomal vesicles formed by the ALS-linked molecule optineurin (OPTN). These vesicles were ubiquitin- and p62-immunopositive and also co-localized with an initiator of the autophagic process, ULK1, after amino acid starvation. An ALS-linked mutation (E478G) in OPTN abolished vesicle formation. ALS-linked mutations in UBQLN2 additively enhanced UBQLN2 aggregation and formation of inclusion bodies, resulting in mislocation from OPTN vesicles. UBQLN2 was found to be a potent regulator of the levels of the FTD-linked secretory factor progranulin, possibly via the endosomal system, and ALS-linked mutations disturbed these functional consequences. This study demonstrates that ALS-linked mutations in both OPTN and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes. These data suggest a novel disease spectrum and provide new pathological insights into OPTN and UBQLN2, enhancing our understanding of the molecular basis of ALS/FTD. 
 Question: Which human disease is associated with mutated UBQLN2
Output: als
Context: Urle lie on the western bank of small and shallow Liwiec river and are surrounded by pine forests. 
 Question: What body of water was Urle next to?
Output: liwiec
Context: Sir Charles Abraham Elton, 6th Baronet (31 October 1778 -- 1 June 1853) was an English officer in the British Army and an author. 
 Question: What military branch was Charles Abraham Elton in?
Output: british army