niryuu/sni-each-converted huggingface dataset:
Context: Facioscapulohumeral muscular dystrophy (FSHD) is a slowly progressive myopathy with autosomal dominant inheritance remarkable for its early involvement of facial musculature. The purpose of our study was to assess the rate of strength deterioration, functional condition and performance of activity of daily living of patients with FSHD in Taiwan. Twenty patients diagnosed with FSHD were included in this study. Manual muscle testing (MMT) was used to evaluate muscle strength. The Brooke and Vignos scales were used to assess upper and lower extremity function respectively, and the capability of the activity of daily living was measured by Barthel index. The result of the strength testing was characterized by the presence of a progressive asymmetrical muscular weakness in patients with FSHD. The mean muscular strength of the right extremity was weaker than its left counterparts (p < 0.05) and the shoulder muscle group was the weakest. According to the Brooke functional scale, 20% of our patients were graded as 1, 30% as grade 2, and 50% as grade 3. On the Vignos functional scale, 50% of patients fell into grade 1, 10% in grade 2, and 40% in grades 3-5. Vignos scale was significantly correlated with mean muscle strength (p < 0.05). The average value of Barthel index was 97.8 +/- 4.7. The muscle strength decline in this Taiwanese of FSHD population was more severe in shoulder girdle area. The mean muscle strength of the right extremity was weaker than the left. Most of our patients suffered from mild or moderate physical disability. Finding of these Taiwanese FSHD population is similar to those reported elsewhere in the world. 
 Question: What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?
Output: autosomal dominant
Context: Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. 
 Question: Which protein does empagliflozin inhibit?
Output: sglt2
Context: When you think of life in the ocean, do you think of fish? Actually, fish are not the most common life forms in the ocean. Plankton are the most common. Plankton make up one of three major groups of marine life. The other two groups are nekton and benthos. Figure 14.24 shows the three groups. Plankton are living things that float in the water. Most plankton are too small to see with the unaided eye. Some examples are shown in Figure 14.25. Plankton are unable to move on their own. Ocean motions carry them along. There are two main types of plankton: 1. Phytoplankton are plant-like plankton. They make food by photosynthesis. They live in the photic zone. Most are algae. 2. Zooplankton are animal-like plankton. They feed on phytoplankton. They include tiny animals and fish larvae. Nekton are living things that swim through the water. They may live at any depth, in the photic or aphotic zone. Most nekton are fish, although some are mammals. Fish have fins and streamlined bodies to help them swim. Fish also have gills to take oxygen from the water. Figure 14.26 shows examples of nekton. Benthos are living things on the ocean floor. Many benthic organisms attach themselves to rocks and stay in one place. This protects them from crashing waves and other water movements. Some benthic organisms burrow into sediments for food or protection. Benthic animals may crawl over the ocean floor. Examples of benthos include clams and worms. Figure 14.27 shows two other examples. Some benthos live near vents on the deep ocean floor. Tubeworms are an example (see Figure 14.28). Scalding hot water pours out of the vents. The hot water contains chemicals that some specialized bacteria can use to make food. Tubeworms let the bacteria live inside them. The bacteria get protection and the tubeworms get some of the food. Figure 14.29 shows a marine food chain. Phytoplankton form the base of the food chain. Phytoplankton are the most important primary producers in the ocean. They use sunlight and nutrients to make food by photosynthesis. Small zooplankton consume phytoplankton. Larger organisms eat the small zooplankton. Larger predators eat these consumers. In an unusual relationship, some enormous whales depend on plankton for their food. They filter tremendous amounts of these tiny creatures out of the water. The bacteria that make food from chemicals are also primary producers. These organisms do not do photosynthesis since there is no light at the vents. They do something called chemosynthesis. They break down chemicals to make food. When marine organisms die, decomposers break them down. This returns their nutrients to the water. The nutrients can be used again to make food. Decomposers in the oceans include bacteria and worms. Many live on the ocean floor. Do you know why? 
 Question: Tubeworms obtain food from
Output: bacteria.
Context: Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a putative chromatin remodeling protein. Neurologic manifestations identified to date relate to enhanced atherosclerosis and cerebrovascular disease. Based on a clinical survey, we determined that half of Schimke immuno-osseous dysplasia patients have a small head circumference, and 15% have social, language, motor, or cognitive abnormalities. Postmortem examination of 2 Schimke immuno-osseous dysplasia patients showed low brain weights and subtle brain histologic abnormalities suggestive of perturbed neuron-glial migration such as heterotopia, irregular cortical thickness, incomplete gyral formation, and poor definition of cortical layers. We found that SMARCAL1 is highly expressed in the developing and adult mouse and human brain, including neural precursors and neuronal lineage cells. These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation. 
 Question: Mutations in which gene cause Schimke immune-osseous dysplasia?
Output: harp
Context: Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a putative chromatin remodeling protein. Neurologic manifestations identified to date relate to enhanced atherosclerosis and cerebrovascular disease. Based on a clinical survey, we determined that half of Schimke immuno-osseous dysplasia patients have a small head circumference, and 15% have social, language, motor, or cognitive abnormalities. Postmortem examination of 2 Schimke immuno-osseous dysplasia patients showed low brain weights and subtle brain histologic abnormalities suggestive of perturbed neuron-glial migration such as heterotopia, irregular cortical thickness, incomplete gyral formation, and poor definition of cortical layers. We found that SMARCAL1 is highly expressed in the developing and adult mouse and human brain, including neural precursors and neuronal lineage cells. These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation. 
 Question: Mutations in which gene cause Schimke immune-osseous dysplasia?
Output: smarcal1 (swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1)
Context: Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a putative chromatin remodeling protein. Neurologic manifestations identified to date relate to enhanced atherosclerosis and cerebrovascular disease. Based on a clinical survey, we determined that half of Schimke immuno-osseous dysplasia patients have a small head circumference, and 15% have social, language, motor, or cognitive abnormalities. Postmortem examination of 2 Schimke immuno-osseous dysplasia patients showed low brain weights and subtle brain histologic abnormalities suggestive of perturbed neuron-glial migration such as heterotopia, irregular cortical thickness, incomplete gyral formation, and poor definition of cortical layers. We found that SMARCAL1 is highly expressed in the developing and adult mouse and human brain, including neural precursors and neuronal lineage cells. These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation. 
 Question: Mutations in which gene cause Schimke immune-osseous dysplasia?
Output: smarcal1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1
Context: Chronic myeloid leukaemia (CML) is characterized cytogenetically by a t(9;22)(q34;ql1) reciprocal translocation which gives origin to a hybrid BCR-ABL gene, encoding a p2lO(BCR-ABL) fusion protein with elevated tyrosine kinase activity and transforming abilities. The t(9;22) was suggested to be associated with genomic imprinting of centromeric regions of chromosomes 9 and 22, but the genes directly affected by the translocation, ABL and BCR, were shown not to be imprinted. For most diagnostic and research purposes the BCR-ABL gene can be efficiently identified by reverse-transcription and polymerase chain reaction (RT/PCR) amplification of its fusion transcripts, which can be quantified by competitive PCR and similar assays for assessment of residual disease in the follow-up of therapy. In the great majority of CML patients the BCR-ABL transcripts exhibit a b2a2 and/or a b3a2 junction; in rare cases, the only detectable BCR-ABL transcripts have unusual junctions, such as b2a3, b3a3, e1a2 or e6a2. There is a recent suggestion that the BCR-ABL gene may not be always 'functional', since extremely low levels of BCR-ABL transcripts can be found in leucocytes from normal individuals and, conversely, it appears that no BCR-ABL transcription can be detected in a proportion of Ph-positive haematopoietic progenitors from some CML patients. The role, if any, of the reciprocal ABL-BCR hybrid gene in CML is unknown. Although its mRNA message is in frame, no ABL-BCR fusion protein has yet been identified in CML patients. The blast crisis of CML has been variably associated with abnormalities of proto-oncogenes, such as RAS and MYC, or of tumour suppressor genes, in particular RB, p53 and p16, or with the generation of chimeric transcription factors, as in the AML1-EVI1 gene fusion. It is likely, therefore, that multiple and alternative molecular defects, as opposed to a single universal mechanism, underlie the acute transformation of the disease. 
 Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
Output: the bcr/abl gene fusion
Context: Chronic myeloid leukaemia (CML) is characterized cytogenetically by a t(9;22)(q34;ql1) reciprocal translocation which gives origin to a hybrid BCR-ABL gene, encoding a p2lO(BCR-ABL) fusion protein with elevated tyrosine kinase activity and transforming abilities. The t(9;22) was suggested to be associated with genomic imprinting of centromeric regions of chromosomes 9 and 22, but the genes directly affected by the translocation, ABL and BCR, were shown not to be imprinted. For most diagnostic and research purposes the BCR-ABL gene can be efficiently identified by reverse-transcription and polymerase chain reaction (RT/PCR) amplification of its fusion transcripts, which can be quantified by competitive PCR and similar assays for assessment of residual disease in the follow-up of therapy. In the great majority of CML patients the BCR-ABL transcripts exhibit a b2a2 and/or a b3a2 junction; in rare cases, the only detectable BCR-ABL transcripts have unusual junctions, such as b2a3, b3a3, e1a2 or e6a2. There is a recent suggestion that the BCR-ABL gene may not be always 'functional', since extremely low levels of BCR-ABL transcripts can be found in leucocytes from normal individuals and, conversely, it appears that no BCR-ABL transcription can be detected in a proportion of Ph-positive haematopoietic progenitors from some CML patients. The role, if any, of the reciprocal ABL-BCR hybrid gene in CML is unknown. Although its mRNA message is in frame, no ABL-BCR fusion protein has yet been identified in CML patients. The blast crisis of CML has been variably associated with abnormalities of proto-oncogenes, such as RAS and MYC, or of tumour suppressor genes, in particular RB, p53 and p16, or with the generation of chimeric transcription factors, as in the AML1-EVI1 gene fusion. It is likely, therefore, that multiple and alternative molecular defects, as opposed to a single universal mechanism, underlie the acute transformation of the disease. 
 Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
Output: abl/bcr fusion
Context: RNA, ribosomal 4, also known as RNR4, is a human gene. 
 Question: Which species has the RNR4 gene?
Output: human
Context: Lewy body disease is a heterogeneous group of neurodegenerative disorders characterized by alpha-synuclein accumulation that includes dementia with Lewy bodies (DLB) and Parkinson's Disease (PD). Recent evidence suggests that impairment of lysosomal pathways (i.e. autophagy) involved in alpha-synuclein clearance might play an important role. For this reason, we sought to examine the expression levels of members of the autophagy pathway in brains of patients with DLB and Alzheimer's Disease (AD) and in alpha-synuclein transgenic mice. By immunoblot analysis, compared to controls and AD, in DLB cases levels of mTor were elevated and Atg7 were reduced. Levels of other components of the autophagy pathway such as Atg5, Atg10, Atg12 and Beclin-1 were not different in DLB compared to controls. In DLB brains, mTor was more abundant in neurons displaying alpha-synuclein accumulation. These neurons also showed abnormal expression of lysosomal markers such as LC3, and ultrastructural analysis revealed the presence of abundant and abnormal autophagosomes. Similar alterations were observed in the brains of alpha-synuclein transgenic mice. Intra-cerebral infusion of rapamycin, an inhibitor of mTor, or injection of a lentiviral vector expressing Atg7 resulted in reduced accumulation of alpha-synuclein in transgenic mice and amelioration of associated neurodegenerative alterations. This study supports the notion that defects in the autophagy pathway and more specifically in mTor and Atg7 are associated with neurodegeneration in DLB cases and alpha-synuclein transgenic models and supports the possibility that modulators of the autophagy pathway might have potential therapeutic effects. 
 Question: Which disease of the central nervous system is characterized by the presence of Lewy bodies?
Output: parkinson's disease (pd)
Context: Hoping to rebound from their three-game losing streak, the Raiders flew to Dolphin Stadium for a Week 11 duel with the Miami Dolphins. In the first quarter, Oakland trailed early as Dolphins WR Ted Ginn, Jr. got a 40-yard TD run. In the second quarter, the Raiders responded with kicker Sebastian Janikowski getting a 21-yard field goal. In the third quarter, Oakland started to catch up as DE Jay Richardson sacked QB Chad Pennington in his own endzone for a safety. Miami would answer with RB Patrick Cobbs getting a 10-yard TD run. In the fourth quarter, the Raiders took the lead as Janikowski got a 37-yard field goal, along with WR Johnnie Lee Higgins returning a punt 93 yards for a touchdown. However, the Dolphins sealed Oakland's fate as kicker Dan Carpenter nailed a 38-yard field goal. 
 Question: Which team kicked the longest field goal?
Output: dolphins
Context: As of the 2010 United States Census, there were 1,951,269 people, 715,365 households, and 467,916 families residing in the county. The population density was . There were 840,343 housing units at an average density of . The racial makeup of the county was 60.9% white, 10.5% black or African American, 8.7% Asian, 0.7% Pacific islander, 0.7% American Indian, 13.5% from other races, and 5.1% from two or more races. Those of Hispanic or Latino origin made up 29.1% of the population. In terms of ancestry, 11.7% were Germans, 9.1% were Irish people, 7.6% were English people, 6.3% were Italians, and 2.7% were Americans. 
 Question: Which group in percent is smaller for the county according to the census: Germans or Americans?
Output: americans
Context: Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand (RANKL) are dominant regulators of bone resorption. Many hormones, cytokines and growth factors mediate bone resorption by altering the ratio of RANKL to OPG. RANKL and OPG expression is also altered in numerous bone diseases, and these changes can reflect disease etiology or compensatory responses to disease. RANKL stimulates osteoclast formation, function and survival, and each of these effects is inhibited by OPG. OPG suppresses bone resorption and increases the density, area and strength of both cancellous and cortical bone. Denosumab (AMG 162), a fully human monoclonal antibody to RANKL, shares the pharmacologic attributes of OPG but has a significantly longer half-life that allows less frequent administration. 
 Question: To the ligand of which receptors does Denosumab (Prolia) bind?
Output: rankl
Context: The Caste War of Yucatan was a conflict that lasted from 1847 to 1901. It began with the revolt of native Maya people led by Maya chiefs Jacinto Pat and Cecilio Chi, against the population of European descent called "Yucatecos", who had political and economic control. A lengthy war ensued between the Yucateco forces in the north-west of the Yucatan and the independent Maya in the south-east. It officially ended with the occupation of the Maya capital of Chan Santa Cruz by the Mexican army in 1901, although skirmishes with villages and small settlements that refused to acknowledge Mexican control continued for over another decade. Adam Jones wrote: "This ferocious race war featured genocidal atrocities on both sides, with up to 200,000 killed." Because of the conflict, on November 24, 1902, Yucatan had a second territorial division when Porfirio Diaz decreed the creation of the Federal Territory of Quintana Roo, with capital in the port of Payo Obispo . In little more than half a century, Yucatan lost more than two thirds of its original territory. 
 Question: What happened first, the revolt of native Maya people, or the occupation of Chan Santa Cruz?
Output: revolt of native maya people
Context: Hoping to snap a three-game losing streak, the Chiefs went home for a Week 12 Sunday night duel with the Pittsburgh Steelers. Kansas City delivered the game's first punch in the opening quarter with a 41-yard field goal from kicker Ryan Succop. The Steelers would answer in the second quarter with kicker Shaun Suisham getting a 21-yard field goal, followed by quarterback Ben Roethlisberger completing a 2-yard touchdown pass to tight end Weslye Saunders. The Chiefs would reply with a 49-yard field goal from Succop, but Pittsburgh would close out the half with Suisham booting a 49-yard field goal. After a scoreless third quarter, Kansas City began to chip away at their deficit in the fourth quarter with a 40-yard field goal from Succop. However, the Steelers' defense held on to preserve the win. 
 Question: Who kicked the second most field goals?
Output: shaun suisham
Context: Smooth Sax Tribute to Earth, Wind and Fire is a tribute album to the R&B band Earth, Wind & Fire by Keyboardist Todd Burrell and Keyboard and Saxophone player Walter Chancellor, Jr. The album was released on May 11, 2004 on Tribute Records and was produced by both Burrell and Chancellor, Jr. 
 Question: Which was the record label for Smooth Sax Tribute to Earth, Wind and Fire?
Output: tribute records
Context: Brian Rowsom (born October 23, 1965) is a retired American professional basketball player who was selected by the Indiana Pacers in the 2nd round (34th overall) of the 1987 NBA Draft. 
 Question: What team did Brian Rowsom play for?
Output: indiana pacers
Context: The Winchester Model 68 was a single-shot, bolt-action .22 caliber rimfire rifle sold from 1934 to 1945 by Winchester Repeating Arms Company. 
 Question: The Winchester Model 68 was produced by whom?
Output: winchester repeating arms company
Context: MS Viking Cinderella is a cruiseferry built in 1989 at Wartsila Marine Perno Shipyard in Turku, Finland, as MS Cinderella for SF Line, one of the owners of the Viking Line consortium. 
 Question: Which corporation created MS Viking Cinderella?
Output: wärtsilä marine
Context: Lydia Potechina (5 September 1883 -- 7 April 1934) was a Russian actress. 
 Question: What was the date of birth of Lydia Potechina?
Output: 5 september 1883
Context: Lysine 1423 of neurofibromin (neurofibromatosis type I gene product [NF1]) plays a crucial role in the function of NF1. Mutations of this lysine were detected in samples from a neurofibromatosis patient as well as from cancer patients. To further understand the significance of this residue, we have mutated it to all possible amino acids. Functional assays using yeast ira complementation have revealed that lysine is the only amino acid that produced functional NF1. Quantitative analyses of different mutant proteins have suggested that their GTPase-activating protein (GAP) activity is drastically reduced as a result of a decrease in their Ras affinity. Such a requirement for a specific residue is not observed in the case of other conserved residues within the GAP-related domain. We also report that another residue, phenylalanine 1434, plays an important role in NF1 function. This was first indicated by the finding that defective NF1s due to an alteration of lysine 1423 to other amino acids can be rescued by a second site intragenic mutation at residue 1434. The mutation partially restored GAP activity in the lysine mutant. When the mutation phenylalanine 1434 to serine was introduced into a wild-type NF1 protein, the resulting protein acquired the ability to suppress activated phenotypes of RAS2Val-19 cells. This suppression, however, does not involve Ras interaction, since the phenylalanine mutant does not stimulate the intrinsic GTPase activity of RAS2Val-19 protein and does not have an increased affinity for Ras proteins. 
 Question: Which is the gene mutated in type 1 neurofibromatosis?
Output: nf1
Context: During mitosis, Promyelocytic leukemia nuclear bodies (PML NBs) change dramatically in morphology and composition, but little is known about function of PML in mitosis. Here, we show that PML is phosphorylated at T409 (PML p409) in a mitosis-specific manner. More importantly, PML p409 contributes to maintain the duration of pro-metaphase and regulates spindle checkpoint. Deficient PML p409 caused a shortening of pro-metaphase and challenged the nocodazole-triggered mitotic arrest. T409A mutation led to a higher frequency of misaligned chromosomes on metaphase plate, and subsequently death in late mitosis. In addition, inhibition of PML p409 repressed growth of tumor cells, suggesting that PML p409 is a potential target for cancer therapy. Collectively, our study demonstrated an important phosphorylated site of PML, which contributed to explore the role of PML in mitosis. 
 Question: What is the effect of nocodazole cell treatment?
Output: mitotic arrest
Context: Kanslikajen (Swedish: ''Chancellery Quay'') is a quay in Gamla stan, the old town of Stockholm, Sweden, leading west along the southern shore of the canal Stallkanalen from Stallbron and Mynttorget to Vasabron. 
 Question: Which is the body of water by Kanslikajen?
Output: stallkanalen
Context: A rock under enough stress will fracture. There may or may not be movement along the fracture. If there is no movement on either side of a fracture, the fracture is called a joint. The rocks below show horizontal and vertical jointing. These joints formed when the confining stress was removed from the rocks as shown in (Figure If the blocks of rock on one or both sides of a fracture move, the fracture is called a fault (Figure 1.2). Stresses along faults cause rocks to break and move suddenly. The energy released is an earthquake. How do you know theres a fault in this rock? Try to line up the same type of rock on either side of the lines that cut across them. One side moved relative to the other side, so you know the lines are a fault. Slip is the distance rocks move along a fault. Slip can be up or down the fault plane. Slip is relative, because there is usually no way to know whether both sides moved or only one. Faults lie at an angle to the horizontal surface of the Earth. That angle is called the faults dip. The dip defines which of two basic types a fault is. If the faults dip is inclined relative to the horizontal, the fault is a dip-slip fault (Figure 1.3). There are two types of dip-slip faults. In a normal fault, the hanging wall drops down relative to the footwall. In a reverse fault, the footwall drops down relative to the hanging wall. This diagram illustrates the two types of dip-slip faults: normal faults and reverse faults. Imagine miners extracting a re- source along a fault. The hanging wall is where miners would have hung their lanterns. The footwall is where they would have walked. A thrust fault is a type of reverse fault in which the fault plane angle is nearly horizontal. Rocks can slip many miles along thrust faults (Figure 1.4). At Chief Mountain in Montana, the upper rocks at the Lewis Overthrust are more than 1 billion years older than the lower rocks. How could this happen? Normal faults can be huge. They are responsible for uplifting mountain ranges in regions experiencing tensional stress. A strike-slip fault is a dip-slip fault in which the dip of the fault plane is vertical. Strike-slip faults result from shear stresses. Imagine placing one foot on either side of a strike-slip fault. One block moves toward you. If that block moves toward your right foot, the fault is a right-lateral strike-slip fault; if that block moves toward your left foot, the fault is a left-lateral strike-slip fault (Figure 1.5). Californias San Andreas Fault is the worlds most famous strike-slip fault. It is a right-lateral strike slip fault (See opening image). People sometimes say that California will fall into the ocean someday, which is not true. Strike-slip faults. Click image to the left or use the URL below. URL: 
 Question: this type of reverse fault has a plane angle that is nearly horizontal.
Output: thrust fault
Context: Villa Saraceno has been dated to the 1540s, which makes it one of Andrea Palladio's earlier works. 
 Question: Who created Villa Saraceno?
Output: andrea palladio
Context: Theatre of Tragedy was a Norwegian band from Stavanger, active between 1993 and 2010. 
 Question: What city is the band Theatre of Tragedy from?
Output: stavanger
Context: The 1974 Norfolk mid-air collision happened on 9 August 1974 at Fordham Fen, Norfolk, England when a Royal Air Force McDonnell-Douglas Phantom FGR2 of 41 Squadron collided with a Piper Pawnee crop spraying aircraft. 
 Question: The point in time of 1974 Norfolk mid-air collision was when?
Output: 9 august 1974
Context: The Seahawks began their 2008 campaign on the road against the Buffalo Bills. In the first quarter, Seattle trailed early as Bills RB Marshawn Lynch got a 21-yard TD run. In the second quarter, the Seahawks continued to struggle as WR/PR Roscoe Parrish returned a punt 63 yards for a touchdown. Seattle responded with QB Matt Hasselbeck completing a 20-yard TD pass to WR Nate Burleson. Buffalo closed out the half with kicker Rian Lindell getting a 35-yard and a 38-yard field goal. In the third quarter, the Seahawks replied with kicker Olindo Mare nailing a 45-yard field goal. However, the Bills pulled a trick play on Seattle. Appearing to go for a 32-yard field goal, Buffalo's holder (punter Brian Moorman) instead threw a 19-yard TD pass to DE Ryan Denney. The Bills pulled away with QB Trent Edwards completing a 30-yard TD pass to TE Robert Royal. 
 Question: Did more field goals occur in the first or second half of the game?
Output: first
Context: The Ayalon River (Hebrew: , Nahal Ayalon; Nahr el-Barideh or Wadi Musrara in Arabic) is a perennial stream in Israel, originating in the Judean Hills and discharging into the Yarkon River in the area of Tel Aviv. 
 Question: What river does Ayalon River form a part of?
Output: yarkon river
Context: Sunda Kelapa (Sundanese: Sunda Kalapa) is the old port of Jakarta located on the estuarine of Ciliwung River. 
 Question: Which is the body of water by Sunda Kelapa?
Output: ciliwung river
Context: Cotinguiba Esporte Clube play their home games at Estadio Lourival Baptista, nicknamed Batistao. 
 Question: Which is the stadium of Cotinguiba Esporte Clube?
Output: batistão
Context: Harley-Davidson, Inc. (H-D), or Harley, is an American motorcycle manufacturer, founded in Milwaukee, Wisconsin in 1903. 
 Question: The product of Harley-Davidson is what?
Output: motorcycle
Context: The Gora Rudnaya mine is one of the largest gold mines in Russia and in the world. 
 Question: What product does Gora Rudnaya mine make?
Output: gold
Context: The Raytown Branch of Mid-Continent Public Library is offering the following activities for the month of March. The library is located at 6131 Raytown Road. All activities are free, but registration is required. Tax Help for Seniors 10 a.m. Mondays and Wednesdays. AARP Tax-Aide representatives will be at the Library to assist seniors with medium to low incomes with tax questions and free tax return preparation. Time listed indicates starting time. Teen Games 2 p.m. March 2. Challenge yourself, challenge your friends. Movie Classics For adults, 2 p.m. March 4. Join us for an afternoon of nostalgia as we watch classic films. Call to see what's showing. KC Zoomobile Africa, for ages 5 and older, 11 a.m. March 5. Join the Kansas City Zoo for an African adventure. We will share African culture as well as show you an animal or two. Come with us to learn something new about Africa. Kids at the Library For ages 6 and older, 11 a.m. March 12. Discover, create, and play. Explore big ideas in a new way. Chess Free Play For ages 6 and older, 1 p.m. March 12. Play chess, learn the basics, brush up on your chess skills, challenge other players at Free Chess Play at the library. The Raytown Branch, in cooperation with the Raytown High School Chess Team coaches, will be hosting chess on the second Saturday of the month from 1 to 3 p.m. Chess boards and chess pieces will be provided. Eggstravaganza Noon March 26. Join us for story time with Mayor Mike McDonough, as we take part in Raytown's Easter festivities. After the stories, the Easter Bunny will escort the children across the street for an Easter egg hunt. 
 Question: Which activity is more likely to develop imagination and creativity?
Output: kids at the library.
Context: 3sat began broadcasting on 1 December 1984. 
 Question: What year did 3sat start?
Output: 1 december 1984
Context: Elections to the European Parliament were held in France on 13 June 2004. 
 Question: What is the full date that Elections to the European Parliament crashed on?
Output: 13 june 2004
Context: The Ruling Voice is a 1931 American Pre Code gangster drama directed by Rowland V. Lee, starring Walter Huston, Loretta Young and Doris Kenyon. 
 Question: In which The Ruling Voice a 1909 american silent drama film directed by?
Output: rowland v. lee
Context: Trying to avoid a five-game losing streak, the Broncos went home for a Week 12 Interconference Duel against the New York Giants. In the first quarter the Broncos got on the board with kicker Matt Prater making a 26-yard field goal and then a 32-yard field goal in the second quarter. The Broncos kept on top with RB Knowshon Moreno making a 1-yard touchdown run. After that Matt Prater made a 47-yard field goal to end the half. In the third quarter the Giants replied with kicker Lawrence Tynes nailing a 39 then a 52-yard field goal. In the fourth quarter Denver increased their lead with QB Kyle Orton making a 17-yard touchdown pass to WR Brandon Stokley, and Prater making a 24-yard field goal. 
 Question: What was the last score type of the first half?
Output: field goal
Context: Imatinib is one of the most recent medications used for the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). It is an orally administered protein-tyrosine kinase inhibitor, an enzyme which is produced by BCR-ABL fusion which results from translocation of 9:22 chromosome (Philadelphia chromosome). Imatinib blocks proliferation and induces apoptosis of BCR-ABL-expression in CML. Many side effects produced by imatinib have been documented but its induction of hepatotoxcity has been rarely reported. Only a few cases so far have been reported in the literature and almost all were in females. We describe another case of hepatotoxicity due to imatinib in a 17-year old female with clinical, laboratory and histopathological changes. The case described here suggests that imatinib may also induce immune hepatitis, in some patients. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: The National American Woman Suffrage Association (NAWSA) was formed on February 18, 1890 to work for women's suffrage in the United States. 
 Question: What is year of inception of National American Woman Suffrage Association?
Output: 1890
Context: Proteins of the Notch family are cell surface receptors that transduce signals between neighbouring cells. The Notch signalling pathway is highly evolutionarily conserved and critical for cell fate determination during embryonic development, including many aspects of vascular development. The interaction of Notch receptors with ligands leads to cleavage of the Notch intracellular domain (NICD) which then translocates to the nucleus and activates the transcription factor CBF1/JBP-Jkappa, regulating downstream gene expression. To date four Notch receptors have been found in mammals. Of these, Notch3 is predominantly expressed in adult arterial smooth muscle cells in human. NOTCH3 gene mutations cause the autosomal dominant condition, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoecephelopathy (CADASIL), an inherited early stroke syndrome leading to dementia due to systemic vascular degeneration. This suggests that Notch3 plays a critical role in maintaining the phenotypic stability of vascular smooth muscle cells (VSMCs). Recent publications indicate that Notch3 is involved in vascular injury and is a determinant of VSMC survival, but its exact function is unknown. The molecular mechanisms underlying CADASIL pathology are therefore intriguing. Investigation of CADASIL mutant Notch3 shows that the majority of mutations do not change CBF1/JBP-Jkappa mediated classic Notch activation, so the pathological consequences of NOTCH3 mutations in CADASIL patients can not be simply explained by loss- or gain-of-function in the classic Notch signalling pathway. This suggests that a novel Notch3-mediated signalling pathway may be present in VSMCs, or cross-regulation of Notch3 to other signalling pathway(s) may play a critical role on VSMCs survival. Alternatively, the mutant Notch3 may gain a novel or toxic function in VSMCs. This review will focus on recent findings of Notch3 in vascular development and in regulating the VSMC behaviour and phenotype, and will use findings on investigating the molecular pathology of the single gene disorder CADASIL to understand the function of Notch3 in VSMCs. 
 Question: Which gene is involved in CADASIL?
Output: notch3 gene
Context: Human apolipoprotein E (apoE) is a 299-amino-acid protein with a molecular weight of 34 kDa. The difference between the apoE3 and apoE4 isoforms is a single residue substitution involving a Cys-Arg replacement at residue 112. ApoE4 is positively associated with atherosclerosis and late-onset and sporadic Alzheimer's disease (AD). ApoE4 and its C-terminal truncated fragments have been found in the senile plaques and neurofibrillary tangles in the brain of AD patients. However, detail structural information regarding isoform and domain interaction remains poorly understood. We prepared full-length, N-, and C-terminal truncated apoE3 and apoE4 proteins and studied their structural variation. Sedimentation velocity and continuous size distribution analysis using analytical ultracentrifugation revealed apoE3(72-299) as consisting of a major species with a sedimentation coefficient of 5.9. ApoE4(72-299) showed a wider and more complicated species distribution. Both apoE3 and E4 N-terminal domain (1-191) existed with monomers as the major component together with some tetramer. The oligomerization and aggregation of apoE protein increased when the C-terminal domain (192-271) was incorporated. The structural influence of the C-terminal domain on apoE is to assist self-association with no significant isoform preference. Circular dichroism and fluorescence studies demonstrated that apoE4(72-299) possessed a more alpha-helical structure with more hydrophobic residue exposure. The structural variation of the N-terminal truncated apoE3 and apoE4 protein provides useful information that helps to explain the greater aggregation of the apoE4 isoform and thus has implication for the involvement of apoE4 in AD. 
 Question: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
Output: apoe4 isoform
Context: Human apolipoprotein E (apoE) is a 299-amino-acid protein with a molecular weight of 34 kDa. The difference between the apoE3 and apoE4 isoforms is a single residue substitution involving a Cys-Arg replacement at residue 112. ApoE4 is positively associated with atherosclerosis and late-onset and sporadic Alzheimer's disease (AD). ApoE4 and its C-terminal truncated fragments have been found in the senile plaques and neurofibrillary tangles in the brain of AD patients. However, detail structural information regarding isoform and domain interaction remains poorly understood. We prepared full-length, N-, and C-terminal truncated apoE3 and apoE4 proteins and studied their structural variation. Sedimentation velocity and continuous size distribution analysis using analytical ultracentrifugation revealed apoE3(72-299) as consisting of a major species with a sedimentation coefficient of 5.9. ApoE4(72-299) showed a wider and more complicated species distribution. Both apoE3 and E4 N-terminal domain (1-191) existed with monomers as the major component together with some tetramer. The oligomerization and aggregation of apoE protein increased when the C-terminal domain (192-271) was incorporated. The structural influence of the C-terminal domain on apoE is to assist self-association with no significant isoform preference. Circular dichroism and fluorescence studies demonstrated that apoE4(72-299) possessed a more alpha-helical structure with more hydrophobic residue exposure. The structural variation of the N-terminal truncated apoE3 and apoE4 protein provides useful information that helps to explain the greater aggregation of the apoE4 isoform and thus has implication for the involvement of apoE4 in AD. 
 Question: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
Output: apolipoprotein e4 isoform
Context: Joaquim Silva (born January 13, 1961) is a retired long-distance runner from Portugal, who won the 1994 edition of the Vienna Marathon. 
 Question: What is Joaquim Silva's country of citizenship?
Output: portugal
Context: The James Bay mine is one of the largest lithium mines in Canada. 
 Question: What product does James Bay mine make?
Output: lithium
Context: The Caste War of Yucatan was a conflict that lasted from 1847 to 1901. It began with the revolt of native Maya people led by Maya chiefs Jacinto Pat and Cecilio Chi, against the population of European descent called "Yucatecos", who had political and economic control. A lengthy war ensued between the Yucateco forces in the north-west of the Yucatan and the independent Maya in the south-east. It officially ended with the occupation of the Maya capital of Chan Santa Cruz by the Mexican army in 1901, although skirmishes with villages and small settlements that refused to acknowledge Mexican control continued for over another decade. Adam Jones wrote: "This ferocious race war featured genocidal atrocities on both sides, with up to 200,000 killed." Because of the conflict, on November 24, 1902, Yucatan had a second territorial division when Porfirio Diaz decreed the creation of the Federal Territory of Quintana Roo, with capital in the port of Payo Obispo . In little more than half a century, Yucatan lost more than two thirds of its original territory. 
 Question: Who had control of the area after 1901?
Output: mexican army
Context: The Patriots clinched their fourth straight AFC East title with a close road win. After a scoreless first quarter, the Jaguars responded to a Gostkowski field goal with a Maurice Jones-Drew touchdown run. The Patriots challenged the play, as Jones-Drew appeared to fall down at the line of scrimmage, but the ruling on the field was upheld. New England came back before the halftime to retake the lead at 10-7 on a Dillon one-yard touchdown run. The Patriots maintained their lead as the teams traded touchdowns in the second half, including another touchdown by Jones-Drew. A David Garrard fumble with 1:55 left in the fourth quarter, recovered by safety Rodney Harrison, sealed the Patriots' 11th win of the season. 
 Question: Which team scored first in the game?
Output: patriots
Context: Plunkett finished the game with 16 out of 25 pass completions for 172 yards and a touchdown. Theismann threw for more yards than Plunkett (243), but was just 16 out of 35 and was intercepted twice. He was also sacked six times. Branch was the top receiver of the game with six receptions for 94 yards and a touchdown. Guy punted seven times for 299 yards (42.7 average), with 244 net yards (34.8 average) and planted five of his seven punts inside the 20. Martin recorded a sack, a pass deflection, and a fumble recovery. Riggins, who had rushed for over 100 yards in his last six postseason games, was held to 64 yards and a touchdown on 26 carries, with his longest gain being just 8 yards. Brown was their top receiver with three receptions for 93 yards. Tight end Clint Didier caught five passes for 65 yards. Garrett recorded 100 yards on kickoff returns, and one reception for 17 yards. Part of both of Allens touchdown runs were cutbacks, which, according to New York Daily News writer Larry Fox, burned an overpursuing Redskins defense. 
 Question: Who had more yards per reception on average, Clint Didier or Brown?
Output: brown
Context: Minors with a stated age <18 years unaccompanied by a responsible adult form an increasing part of refugees to Europe. They are older than other asylum-seeking children and many come from countries with a high tuberculosis (TB) incidence. During the 2015 refugee crisis, 35,369 of 162,877 refugees (22%) seeking asylum in Sweden were unaccompanied minors, which gave us the opportunity to study their burden of TB infection and disease. Of the unaccompanied minors seeking asylum in Sweden during 2015, 2936 (8.3%) were allocated to northern Stockholm. Of these, 2422 were from countries with an incidence of TB exceeding 100/10 Of those screened, 349 had a positive test and were referred to the northern paediatric TB clinic at Astrid Lindgren Children's Hospital. Of these, 16 had TB disease and 278 latent tuberculosis infection (LTBI), while we considered 53 uninfected. In addition, eight sought medical attention with symptomatic TB outside the screening system. Cohort rates were 6.8% of LTBI and 0.5% of TB in minors from Afghanistan and 26-32% of LTBI and 3.4-3.5% of TB among those from Eritrea, Ethiopia or Somalia. We conclude that TB infection and disease is common among asylum-seeking unaccompanied minors, especially among those from the Horn of Africa. 
 Question: The Mantoux test detects what latent infection/disease?
Output: tuberculosis
Context: Centrioles are essential for the formation of cilia and flagella. They also form the core of the centrosome, which organizes microtubule arrays important for cell shape, polarity, motility and division. Here, we have used super-resolution 3D-structured illumination microscopy to analyse the spatial relationship of 18 centriole and pericentriolar matrix (PCM) components of human centrosomes at different cell cycle stages. During mitosis, PCM proteins formed extended networks with interspersed -Tubulin. During interphase, most proteins were arranged at specific distances from the walls of centrioles, resulting in ring staining, often with discernible density masses. Through use of site-specific antibodies, we found the C-terminus of Cep152 to be closer to centrioles than the N-terminus, illustrating the power of 3D-SIM to study protein disposition. Appendage proteins showed rings with multiple density masses, and the number of these masses was strongly reduced during mitosis. At the proximal end of centrioles, Sas-6 formed a dot at the site of daughter centriole assembly, consistent with its role in cartwheel formation. Plk4 and STIL co-localized with Sas-6, but Cep135 was associated mostly with mother centrioles. Remarkably, Plk4 formed a dot on the surface of the mother centriole before Sas-6 staining became detectable, indicating that Plk4 constitutes an early marker for the site of nascent centriole formation. Our study provides novel insights into the architecture of human centrosomes and illustrates the power of super-resolution microscopy in revealing the relative localization of centriole and PCM proteins in unprecedented detail. 
 Question: Where in the cell do we find the protein Cep135?
Output: centrosome
Context: The Duke's Cut was completed by the Duke of Marlborough in 1789 to link the new canal with the River Thames; and, in 1796, the Oxford Canal company built its own link to the Thames, at Isis Lock. 
 Question: By which body of water is Oxford located?
Output: river thames