niryuu/sni-each-converted huggingface dataset:
Context: A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) to develop evidence-based and consensus-based recommendations for the long-term pharmacologic treatment of restless legs syndrome/Willis-Ekbom disease (RLS/WED). The Task Force reviewed the results of all studies of RLS/WED treatments with durations of 6 months or longer presented at meetings over the past 2 years, posted on Web sites of pharmaceutical companies, or published in peer-reviewed journals, asking the questions, "What is the efficacy of this treatment in patients with RLS/WED?" and "What is the safety of this treatment in patients with RLS/WED?" The Task Force developed guidelines based on their review of 61 papers meeting inclusion criteria, and using a modified evidence-grading scheme. Pregabalin has been established as effective for up to 1 year in treating RLS/WED (Level A evidence). Pramipexole, ropinirole, and rotigotine have been established as effective for up to 6 months in treating RLS/WED (Level A). The following drugs have been established as probably effective (Level B) in treating RLS/WED for durations ranging from 1 to 5 years: gabapentin enacarbil, pramipexole, and ropinirole (1 year); levodopa (2 years); and rotigotine (5 years). Because of associated safety concerns, pergolide and cabergoline should not be used in the treatment of RLS/WED unless the benefits clearly outweigh the risks. Other pharmacologic therapies have insufficient evidence to support their long-term use in treating RLS/WED. The IRLSSG Task Force also developed consensus-based strategies for the prevention and treatment of complications (such as augmentation, loss of efficacy, excessive daytime sleepiness, and impulse control disorders) that may develop with the long-term pharmacologic treatment of RLS/WED. The use of either a dopamine-receptor agonist or 2 calcium-channel ligand is recommended as the first-line treatment of RLS/WED for most patients, with the choice of agent dependent on the patient's severity of RLS/WED symptoms, cognitive status, history, and comorbid conditions. 
 Question: Willis-Ekbom disease is also known as?
Output: restless legs syndrome
Context: Thomas Magnay (14 September 1876 -- 3 November 1949) was a Liberal Party politician in the United Kingdom, who joined the breakaway Liberal National faction and served as a Member of Parliament (MP) from 1931 to 1945. 
 Question: Which country's citizen was Thomas Magnay?
Output: united kingdom
Context: McLeod syndrome is a rare X-linked neuroacanthocytosis syndrome with hematologic, muscular, and neurologic manifestations. McLeod syndrome is caused by mutations in the XK gene whose product is expressed at the red blood cell (RBC) surface but whose function is currently unknown. A variety of XK mutations has been reported but no clear phenotype-genotype correlation has been found, especially for the point mutations affecting splicing sites. A man suspected of neuroacanthocytosis was evaluated by neurologic examination, electromyography, muscle biopsy, muscle computed tomography, and cerebral magnetic resonance imaging. The McLeod RBC phenotype was disclosed by blood smear and immunohematology analyses and then confirmed at the biochemical level by Western blot analysis. The responsible XK mutation was characterized at the mRNA level by reverse transcription-polymerase chain reaction (PCR), identified by genomic DNA sequencing, and verified by allele-specific PCR. A novel XK splice site mutation (IVS1-1G>A) has been identified in a McLeod patient who has developed hematologic, neuromuscular, and neurologic symptoms. This is the first reported example of a XK point mutation affecting the 3' acceptor splice site of Intron 1, and it was demonstrated that this mutation indeed induces aberrant splicing of XK RNA and lack of XK protein at the RBC membrane. The detailed characterization at the molecular biology level of this novel XK splice site mutation associated with the clinical description of the patient contributes to a better understanding of the phenotype-genotype correlation in the McLeod syndrome. 
 Question: Mutation of which gene is associated with McLeod syndrome?
Output: xk
Context: Alexander Military Law Academy (Russian: - ) (1867--1917) was an educational institution in Russian Empire that provided military law education for officers of Russian Army and Fleet. 
 Question: What year did Alexander Military Law Academy end?
Output: 1917
Context: Erythrasma is an uncommon vulvar infection, best diagnosed by its fluorescence under the Wood lamp. This report shows that despite a negative Wood lamp examination, the diagnosis can be made histologically. A 42-year-old woman was referred to our clinic with a persistent candidal infection. Evaluation included a Wood lamp examination, wet mount, and potassium hydroxide test of the affected skin, all of which were negative. A biopsy of the area demonstrated rods and filamentous organisms in the keratotic layer consistent with a Corynebacterium minutissimum infection. The patient was diagnosed as having erythrasma, and she responded to oral erythromycin. Persistent vulvar diseases may be caused by erythrasma despite a negative Wood lamp examination. The diagnosis can be made by biopsy of the lesion. 
 Question: Which bacteria causes erythrasma?
Output: corynebacterium minutissimum
Context: The 19th Light Dragoons was a cavalry regiment of the British Army created in 1781 for service in British India. 
 Question: What branch was 19th Light Dragoons part of?
Output: british army
Context: 118401 LINEAR (provisional designation 1999 RE70) is an asteroid and main-belt comet (176P/LINEAR) that was discovered by the Lincoln Near-Earth Asteroid Research (LINEAR) 1-metre telescopes in Socorro, New Mexico on September 7, 1999. 
 Question: Who made 118401 LINEAR known?
Output: lincoln near-earth asteroid research
Context: Benny's Bathtub (Original title: Bennys badekar) is a 1971 Danish animated film directed by Jannik Hastrup and Flemming Quist Mller. 
 Question: The movie Benny's Bathtub was directed by whom?
Output: flemming quist møller
Context: The Parson and the Outlaw is a 1957 American western directed by Oliver Drake for Charles 'Buddy' Rogers Productions and distributed by Columbia Pictures. 
 Question: What is the name of the company which distributed The Parson and the Outlaw?
Output: columbia pictures
Context: Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy. 
 Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Output: zeb2
Context: Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy. 
 Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Output: zfhx1b
Context: Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy. 
 Question: Which gene is responsible for the development of the Mowat-Wilson syndrome?
Output: sip-1
Context: Punarvasu) is a Nakshatra in Hindu astrology, which refers to the two brightest stars in the constellation of Gemini: 
 Question: What constellation does Punarvasu belong to?
Output: gemini
Context: The District of Keewatin was a territory of Canada and later an administrative district of the Northwest Territories. 
 Question: What was replaced District of Keewatin?
Output: northwest territories
Context: Gaius Julius Alexander Berenicianus (Greek: , about 75 -- about 150) was a Cilician Prince and second-born son to King Gaius Julius Alexander and Queen Julia Iotapa of Cetis. 
 Question: Which woman was the sister of Gaius Julius Alexander Berenicianus?
Output: julia iotapa
Context: The launch occurred at 17:00 UTC on 12 September 1967, and resulted in Kosmos 176's successful deployment into Low earth orbit. 
 Question: On what date did Kosmos 176 lift off?
Output: 12 september 1967
Context: It had been some time since Jack had seen the old man.Over the phone ,his mother told him,"Mr.Belser died last night ,The funeral is Wednesday."Memories flashed through his mind like an old newsreel as he sat quietly remembering his childhood days. When Jack was very young ,his father died.Mr Belser,who lived in the same neighborhood with them,spent as much time as he could to make sure Jack had a man's influence in his life.He spent a lot of time teachimg Jack he thought what was important in his following life.If Mr.Belser hadn' taught him how to weave,he wouldn't be in this business now.So he promised his mother he would attend Mr.Belser's funeral. "You'd better not drive your car.It's a long way."his mother warned him. Busy as he was,he kept his word.Though tired from the earliest flight,Jack tried his best to help.Mr.Belser's funeral was small because he had no children of his own and most of his s had passed away. The night before he had to return home,Jack and his mother stopped by to see the old house Mr.Belser once lived.Now it belonged to him.He bought the house from one of his s. The house was exactly as he remembered.Every step held memories.Every picture,every piece of furniture... Jadk stopped suddenly. The box on his desk was gone!He once asked the old man what was inside.He just smiled and said it was the most valuable thing to him,though it almost cost nothing to others.He figured that someone from the Belser family had taken it ."I will never know what was so valuable to him."Jack thought disappotntedly. Three days later returning home from work,Jack discovered a small package in his mailbox. The handwriting was difficult to read,but the return address caught his attention."Mr.Harold Belser"it read. Jack couldn't wait to open it .Inside lay the familiar small box.His heart racing,Jack unlocked the box.Inside he found a gold pocket watch with these words engraved:"Jack,Thanks for your time!Harold Belser." "The thing he valued most was my time."Jack held the watch before his chest,tears filling his eyes. 
 Question: What did Mr.Belser teach Jack when he aws young?
Output: how to weave.
Context: Sigurd Wallin was the son of the Swedish artist David Wallin (1876-1957) and his wife Elin Wallin (1884-1969), born Lundberg, Stockholm. 
 Question: What is Sigurd Wallin's father's name?
Output: david wallin
Context: A personal journey into the heart of the Killing FieldsOne of the most harrowing and compelling personal documentaries of our time, ENEMIES OF THE PEOPLE exposes for the first time the truth about the Killing Fields and the Khmer Rouge who were behind Cambodias horrific genocide. More than simply an inquiry into Cambodias experience, however, ENEMIES OF THE PEOPLE is a profound meditation on the nature of good and evil, shedding light on the capacity of some people to do terrible things and for others to forgive them.Winner of a dozen top documentary festival awards, including a Special Jury Prize at Sundance and the Grand Jury Award at the Full Frame Documentary Festival, this is a riveting film that takes audiences as close to witnessing evil as they are ever likely to get. It is also a personal journey into the heart of darkness by journalist/filmmaker Thet Sambath, whose family was wiped out in the Killing Fields, but whose patience and discipline elicits unprecedented on-camera confessions from perpetrators at all levels of the Khmer Rouge hierarchy. This is investigative journalism of the highest order.In 1974, Thet Sambaths father became one of the nearly two million people who were murdered by the Khmer Rouge when he refused to give them his buffalo. Sambaths mother was forced to marry a Khmer Rouge militiaman and died in childbirth in 1976, while his eldest brother disappeared in 1977. Sambath himself escaped Cambodia at age 10 when the Khmer Rouge fell in 1979.Fast forward to 1998, and Sambath, now a journalist, got to know the children of some senior Khmer Rouge cadre and gradually earned their trust. Then, for a decade, he spent weekends visiting the home of the most senior surviving leader, Nuon Chea, aka Brother Number Two under Pol Pot. But he never used to say anything different from what he told Western journalists, says Sambath, I was low-ranking, I knew nothing, I am not a killer. Then one day he said to me Sambath, I trust you, you are the person I would like to tell my story to. Ask me what you want to know. For the next five years he told me the truth, as he saw it, including all the details of killing.Sambath also won the confidence of lower-level Khmer Rouge soldiers, now ordinary fathers and grandfathers, who demonstrated to him how they slit peoples throats. For these murderers, it was the first time they admitted what they had done. He taped their interactions and discussions about the killings, and together with British documentarian Rob Lemkin they created this landmark film.For Sambath, it has been an ongoing, lifelong personal journey to discover what was behind such horror; he neglected both his family and his own happiness in the search for truth with hope of reconciliation. ENEMIES OF THE PEOPLE is at once a cinematically beautiful, chillingly insightful, and deeply personal piece of documentary filmmaking. 
 Question: What regime was Nuon Chea unwilling to talk about in regards to his political career?
Output: khmer rouge
Context: Simon Miller (Loren Dean) outwardly appears to be a geologist who must frequently take business trips, which has strained the relationship with his family, including his wife Meredith (Robyn Lively) and teenage children Sarah (Skyler Day) and Kevin (Drew Koles). When Simon suddenly goes missing, his family searches his office and discovers several passports, each with different aliases. They soon learn that Simon was in fact a spy who kept his true career secret from them. Simon mysteriously calls home and warns his family not to tell anyone about his disappearances, then abruptly hangs up. His family begins a search for Simon, which takes them to locations around the world. Sarah, an honor student, uses her foreign language skills to help, and Kevin uses his knowledge of technology.[1] They receive assistance from Amanda (Christine Baranski), another covert operative who initially appears to be a friend, but appears to have her own motives.[2] 
 Question: What do they find in Simon's office?
Output: several passports
Context: STS-115 launched from Pad 39-B at the Kennedy Space Center on 9 September 2006 at 11:14:55 EDT (15:14:55 UTC). 
 Question: What was the date STS-115 was launched?
Output: 9 september 2006
Context: Since the early 2000s, the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections among the community of people lacking known healthcare risk factors has increased. This MRSA infection is referred to as community-associated MRSA (CA-MRSA) infection and is distinct from hospital-associated MRSA (HA-MRSA) infection, which occurs among people with known healthcare risk factors. Understanding the epidemiology of CA-MRSA infections is critical; however, this has not been investigated in detail in Japan. Our objective was to investigate the incidence of CA-MRSA infections in a regional hospital. We investigated CA-MRSA isolates and infections in a rural regional hospital by reviewing medical records of one year. Infections were classified as CA-MRSA if no established risk factors were identified. During 2008, 31 Staphylococcus aureus (S. aureus) isolates were detected in 29 unique patients, with 1 methicillin-sensitive S. aureus (MSSA) isolates obtained from 19 patients (66%) and MRSA obtained from 10 patients (34%). In the 10 patients with MRSA, the number of HA-MRSA and CA-MRSA cases were nine (32% of patients with S. aureus isolates) and one (3%), respectively. The patient with CA-MRSA was diagnosed with cellulitis due to CA-MRSA. All nine patients with HA-MRSA exhibited colonization. We observed a CA-MRSA case in a regional hospital in Japan, suggesting that incidence trends of CA-MRSA should be considered in future research and treatment. 
 Question: What is MRSA?
Output: mrsa
Context: Since the early 2000s, the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections among the community of people lacking known healthcare risk factors has increased. This MRSA infection is referred to as community-associated MRSA (CA-MRSA) infection and is distinct from hospital-associated MRSA (HA-MRSA) infection, which occurs among people with known healthcare risk factors. Understanding the epidemiology of CA-MRSA infections is critical; however, this has not been investigated in detail in Japan. Our objective was to investigate the incidence of CA-MRSA infections in a regional hospital. We investigated CA-MRSA isolates and infections in a rural regional hospital by reviewing medical records of one year. Infections were classified as CA-MRSA if no established risk factors were identified. During 2008, 31 Staphylococcus aureus (S. aureus) isolates were detected in 29 unique patients, with 1 methicillin-sensitive S. aureus (MSSA) isolates obtained from 19 patients (66%) and MRSA obtained from 10 patients (34%). In the 10 patients with MRSA, the number of HA-MRSA and CA-MRSA cases were nine (32% of patients with S. aureus isolates) and one (3%), respectively. The patient with CA-MRSA was diagnosed with cellulitis due to CA-MRSA. All nine patients with HA-MRSA exhibited colonization. We observed a CA-MRSA case in a regional hospital in Japan, suggesting that incidence trends of CA-MRSA should be considered in future research and treatment. 
 Question: What is MRSA?
Output: methicillin-resistant s. aureus
Context: Diamond-Blackfan anemia (DBA) features hypoplastic anemia and congenital malformations, largely caused by mutations in various ribosomal proteins. The aim of this study was to characterize the spectrum of genetic lesions causing DBA and identify genotypes that correlate with phenotypes of clinical significance. Seventy-four patients with DBA from across Canada were included. Nucleotide-level mutations or large deletions were identified in 10 ribosomal genes in 45 cases. The RPS19 mutation group was associated with higher requirement for chronic treatment for anemia than other DBA groups. Patients with RPS19 mutations, however, were more likely to maintain long-term corticosteroid response without requirement for further chronic transfusions. Conversely, patients with RPL11 mutations were less likely to need chronic treatment. Birth defects, including cardiac, skeletal, hand, cleft lip or palate and genitourinary malformations, also varied among the various genetic groups. Patients with RPS19 mutations had the fewest number of defects, while patients with RPL5 had the greatest number of birth defects. This is the first study to show differences between DBA genetic groups with regards to treatment. Previously unreported differences in the rate and types of birth defects were also identified. These data allow better patient counseling, a more personalized monitoring plan, and may also suggest differential functions of DBA genes on ribosome and extra-ribosomal functions. 
 Question: In which syndrome is the RPS19 gene most frequently mutated?
Output: dba
Context: Diamond-Blackfan anemia (DBA) features hypoplastic anemia and congenital malformations, largely caused by mutations in various ribosomal proteins. The aim of this study was to characterize the spectrum of genetic lesions causing DBA and identify genotypes that correlate with phenotypes of clinical significance. Seventy-four patients with DBA from across Canada were included. Nucleotide-level mutations or large deletions were identified in 10 ribosomal genes in 45 cases. The RPS19 mutation group was associated with higher requirement for chronic treatment for anemia than other DBA groups. Patients with RPS19 mutations, however, were more likely to maintain long-term corticosteroid response without requirement for further chronic transfusions. Conversely, patients with RPL11 mutations were less likely to need chronic treatment. Birth defects, including cardiac, skeletal, hand, cleft lip or palate and genitourinary malformations, also varied among the various genetic groups. Patients with RPS19 mutations had the fewest number of defects, while patients with RPL5 had the greatest number of birth defects. This is the first study to show differences between DBA genetic groups with regards to treatment. Previously unreported differences in the rate and types of birth defects were also identified. These data allow better patient counseling, a more personalized monitoring plan, and may also suggest differential functions of DBA genes on ribosome and extra-ribosomal functions. 
 Question: In which syndrome is the RPS19 gene most frequently mutated?
Output: diamond-blackfan anemia
Context: Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated in the hippocampus during synaptic plasticity, calcium/calmodulin-dependent protein kinase II (CaMKII) robustly phosphorylated the regulatory site (threonine 171) in CPEB in vitro. In postsynaptic density fractions or hippocampal neurons, CPEB phosphorylation increased when CaMKII was activated. These increases in CPEB phosphorylation were attenuated by a specific peptide inhibitor of CaMKII and by the general CaM-kinase inhibitor KN-93. Inhibitors of protein phosphatase 1 increased basal CPEB phosphorylation in neurons; this was also attenuated by a CaM-kinase inhibitor. To determine whether CaM-kinase activity regulates CPEB-dependent mRNA translation, hippocampal neurons were transfected with luciferase fused to a 3' UTR containing CPE-binding elements. Depolarization of neurons stimulated synthesis of luciferase; this was abrogated by inhibitors of protein synthesis, mRNA polyadenylation, and CaMKII. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity. 
 Question: Which kinase is inhibited by the small molecule KN-93?
Output: cam kinase ii
Context: Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated in the hippocampus during synaptic plasticity, calcium/calmodulin-dependent protein kinase II (CaMKII) robustly phosphorylated the regulatory site (threonine 171) in CPEB in vitro. In postsynaptic density fractions or hippocampal neurons, CPEB phosphorylation increased when CaMKII was activated. These increases in CPEB phosphorylation were attenuated by a specific peptide inhibitor of CaMKII and by the general CaM-kinase inhibitor KN-93. Inhibitors of protein phosphatase 1 increased basal CPEB phosphorylation in neurons; this was also attenuated by a CaM-kinase inhibitor. To determine whether CaM-kinase activity regulates CPEB-dependent mRNA translation, hippocampal neurons were transfected with luciferase fused to a 3' UTR containing CPE-binding elements. Depolarization of neurons stimulated synthesis of luciferase; this was abrogated by inhibitors of protein synthesis, mRNA polyadenylation, and CaMKII. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity. 
 Question: Which kinase is inhibited by the small molecule KN-93?
Output: calcium/calmodulin-dependent protein kinase ii
Context: Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated in the hippocampus during synaptic plasticity, calcium/calmodulin-dependent protein kinase II (CaMKII) robustly phosphorylated the regulatory site (threonine 171) in CPEB in vitro. In postsynaptic density fractions or hippocampal neurons, CPEB phosphorylation increased when CaMKII was activated. These increases in CPEB phosphorylation were attenuated by a specific peptide inhibitor of CaMKII and by the general CaM-kinase inhibitor KN-93. Inhibitors of protein phosphatase 1 increased basal CPEB phosphorylation in neurons; this was also attenuated by a CaM-kinase inhibitor. To determine whether CaM-kinase activity regulates CPEB-dependent mRNA translation, hippocampal neurons were transfected with luciferase fused to a 3' UTR containing CPE-binding elements. Depolarization of neurons stimulated synthesis of luciferase; this was abrogated by inhibitors of protein synthesis, mRNA polyadenylation, and CaMKII. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity. 
 Question: Which kinase is inhibited by the small molecule KN-93?
Output: camk2
Context: Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated in the hippocampus during synaptic plasticity, calcium/calmodulin-dependent protein kinase II (CaMKII) robustly phosphorylated the regulatory site (threonine 171) in CPEB in vitro. In postsynaptic density fractions or hippocampal neurons, CPEB phosphorylation increased when CaMKII was activated. These increases in CPEB phosphorylation were attenuated by a specific peptide inhibitor of CaMKII and by the general CaM-kinase inhibitor KN-93. Inhibitors of protein phosphatase 1 increased basal CPEB phosphorylation in neurons; this was also attenuated by a CaM-kinase inhibitor. To determine whether CaM-kinase activity regulates CPEB-dependent mRNA translation, hippocampal neurons were transfected with luciferase fused to a 3' UTR containing CPE-binding elements. Depolarization of neurons stimulated synthesis of luciferase; this was abrogated by inhibitors of protein synthesis, mRNA polyadenylation, and CaMKII. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity. 
 Question: Which kinase is inhibited by the small molecule KN-93?
Output: the calcium/calmodulin-dependent protein kinase-ii
Context: Khivi (1506--1582) also referred to as Mata Khivi or Bibi Khivi was the wife of Guru Angad Dev, second Sikh guru. 
 Question: What is Khivi's spouse's name?
Output: guru angad dev
Context: Josef Steudel (21 July 1917 -- 4 May 2004) was a highly decorated Hauptmann in the Luftwaffe during World War II, and a recipient of the Knight's Cross of the Iron Cross. 
 Question: In what war did Josef Steudel fight?
Output: world war ii
Context: Leptoxis ampla is a vulnerable species according to the IUCN Red list. 
 Question: What is an ecological status of Leptoxis ampla?
Output: vulnerable
Context: The Dolphins' eighth game was an AFC duel with the Ravens. The Dolphins trailed early after QB Joe Flacco completed a 32-yard TD pass to RB Willis McGahee. They replied with RB Ronnie Brown getting a 12-yard TD run. The Ravens got the lead back after kicker Billy Cundiff made a 26 and a 39-yard field goal. The Dolphins narrowed the lead with kicker Dan Carpenter nailing a 19-yard field goal. The Dolphins fell further behind after Flacco found WR Derrick Mason on a 12-yard TD pass. This was followed in the 4th quarter by Cundiff hitting a 20 and a 24-yard field goal. 
 Question: Who kicked the longest field goal?
Output: billy cundiff
Context: Petr Prajsler (born September 21, 1965 in Hradec Kralove, Czechoslovakia) is a retired Czech ice hockey defenceman who played in the National Hockey League for the Los Angeles Kings between 1987 to 1990 and the Boston Bruins in 1991. 
 Question: What team does Petr Prajsler belong to?
Output: los angeles kings
Context: Aud Alvr (27 November 1921 -- 11 June 2000) was a Norwegian politician for the Liberal Party. 
 Question: What party does Aud Alvr serve?
Output: liberal party
Context: Dorothee Bar (nee Mantel, born 19 April 1978 in Bamberg, Bavaria) is a German politician that has served as the National Deputy Secretary General of the Christian Social Union of Bavaria since 2009. 
 Question: From which political party is Dorothee Bar?
Output: christian social union of bavaria
Context: Hamzeh Al Aitoni (Arabic: ) (born 16 January 1986 in Damascus, Syria) is a Syrian footballer who plays as a defender for Al-Nidal, which competes in the Syrian Premier League and is a member of the Syria national football team. 
 Question: In what capacity did Hamzeh Al Aitoni play football?
Output: defender
Context: Father's day Sunset Live Music Dinner Cruise Sunday, June 16th, 2013 6:30pm-8:30pm Join us abroad the 95' Dana Pride for our special Father's Day Dinner Cruise. Enjoy a unique evening of fun on the water, complete with live music by Mike O' Brien and a delicious barbecue dinner. Adult--$ 59 Kids (3-12)--$29 Two and under are Free LOCATION: Dana Point Harbor BOOK ONLINE OR CALL: 949-496-5794 Rancho Days Fiesta July 13, 2013 Celebration the history of Saddleback Valley, there will be children's activities including free crafts projects. Help make and taste homemade ice cream and butter, warm bread from the oven. Dip water and grind corn while learning about the early days of Orange County. Admission is $ 3 for children 3 to 12 years old and $4 for adults. LOCATION: Heritage Hill Historical Park INFORMATION: 949-923-2230 Annual Silverado Counter Fair and Art Festival October 5-6, 2013 The 42thAnnual Silverado Country Fair explores the wonders of the area's Old West rustic culture, great live music tasty food, handmade arts, crafts and family games under the oak-trees below Orange Country's famous Saddleback Mountain. Daytime adult admission: $4/ Kids under 12: only $2 Saturday Night Music Fest : $ 5 for everyone LOCATION: Silverado Community Center INFORMATION: 714-997-3968 Starr Ranch Sanctuary October 20-21, 2013 Audubon California's Starr Ranch Sanctuary invites you to our fall classes for adults. Join our wildlife biologist for two peaceful days at beautiful 4,000 acre Starr Ranch in southeast Orange County and experience nature hands-on as a wildlife researcher. Cost: $ 95 for those not camping (including dinner) $100 for those camping (dinner and breakfast provided) LOCATION: Starr Ranch Sanctuary RESERVATIONS OR INFORMATION: 949-858-0309 
 Question: Which event is the most suitable for one who wants to enjoy dinner in a boat with live music?
Output: father's day sunset live music dinner cruise.
Context: Australia is the smallest continent in the world. It is a little smaller than China. It is on the Southern Hemisphere of the earth. Australia is big, but its population is small. The population of Australia is nearly as large as that of Shanghai. Enough laws have been made to fight against pollution. The cities in Australia have little air or water pollution. The sky is blue and the water is clean. You can clearly see fish in the rivers. Plants grow very well. Last month we visited Perth, the biggest city in Western Australia, and went to a wild flower _ . There we saw large numbers of wild flowers on show, most of which we had never seen before. We had a wonderful time. Perth is famous for its beautiful wild flowers. Every year in spring Perth has wild flower exhibitions. After visiting Perth, we spent a day in the countryside. We sat down and had a rest near a path at the foot of a hill. It was quiet and we enjoyed ourselves very much. When we heard bells ringing at the top of the hill, we looked up, but what we saw made us pick up all our things and run back to our car as quickly as we could. There were about three hundred sheep coming towards us along the path. Australia is famous for its sheep and kangaroos . After a short drive from any town, you will find yourself among the white sheep. Sheep, sheep, everywhere you can see sheep. 
 Question: Which country is the writer most possibly from?
Output: china
Context: Stockholm Monsters were a post-punk band from Burnage in Manchester who recorded for Factory Records between 1981 and 1987. 
 Question: What city is the band Stockholm Monsters from?
Output: manchester
Context: Do you want to visit Disney World? However, will you worry about your pet if you go to Disney World? To meet the needs of these people, a pet hotel has been built near the Disney World Resort in Florida. The new pet hotel is named Best Friends Pet Care Resort and it is mainly open to dogs and cats. It has an area of 4,645m2. About 270 dogs and 30 cats can be kept there at the same time. Besides dogs and cats, it can also provide services for birds, pigs and rabbits. However, it can't take care of snakes and turtles now. Best Friend Pet Care Resort is a very expensive hotel. There are several types of dog rooms, such as rooms with air-conditioners and VIP rooms. There is even a "private dog park". Owners can have a high-quality vacation with their dogs there. The cats are kept in the "Kitty City". The "Kitty City" is very comfortable and clean. Workers there will clean it once a day. Apart from having good equipment, Best Friends Pet Care Resort also have other plans to meet the psychological needs of pets. Workers play music to the pets, walk with them, play with them and even read stories to them before they go to bed. "We aim to make sure that pets will have a fun vacation here, just like their owners at Disney World," said the manager of the resort. 
 Question: How often do the workers clean the "Kitty City"?
Output: once a day.
Context: Treslin/TICRR (TopBP1-interacting, replication stimulating protein/TopBP1-interacting, checkpoint, and replication regulator), the human ortholog of the yeast Sld3 protein, is an essential DNA replication factor that is regulated by cyclin-dependent kinases and the DNA damage checkpoint. We identified MDM two binding protein (MTBP) as a factor that interacts with Treslin/TICRR throughout the cell cycle. We show that MTBP depletion by means of small interfering RNA inhibits DNA replication by preventing assembly of the CMG (Cdc45-MCM-GINS) holohelicase during origin firing. Although MTBP has been implicated in the function of the p53 tumor suppressor, we found MTBP is required for DNA replication irrespective of a cell's p53 status. We propose that MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. 
 Question: Which factor interacts with Treslin/TICRR throughout the cell cycle of human cells?
Output: mdm two binding protein (mtbp)
Context: Bacterial species composition in the gut has emerged as an important factor in obesity and its related metabolic diseases such as type 2 diabetes. Out of thousands of bacterial species-level phylotypes inhabiting the human gut, the majority belong to two dominant phyla, the Bacteroidetes and Firmicutes. Members of the Bacteroidetes in particular have been associated with human metabolic diseases. However, their associations with disease are not always consistent between studies. Delving deeper into the diversity within the Bacteroidetes reveals a vast diversity in genomes and capacities, which partly explain how not all members respond equally to similar environmental conditions in their hosts. Here, we discuss the Bacteroidetes phylum, associations of its members with metabolic phenotypes, and efforts to characterize functionally their interactions with their hosts. Harnessing the Bacteroidetes to promote metabolic health will require a nuanced understanding of how specific strains interact with their microbial neighbors and their hosts under various conditions. 
 Question: Which are the two main bacterial phyla in human gut?
Output: bacteroidetes and firmicutes
Context: The Geysers were first seen by Euro/Americans and named in 1847 during John Fremont's survey of the Sierra Mountains and the Great Basin by William Bell Elliot who called the area ''The Geysers,'' although the geothermal features he discovered were not technically geysers, but fumaroles. 
 Question: When was the The Geysers discovered?
Output: 1847
Context: The Rose Experience is the fourth studio album by multi-platinum R&B singer Case. 
 Question: What is the name of the artist or group which originally performed The Rose Experience?
Output: case
Context: The police must investigate a series of robberies along a strip of land in the city. The new mayor of the city (Kenneth Mars) assigns Captain Harris (G.W. Bailey) and Lt. Proctor (Lance Kinsey) to the case, but while on stakeout the Wilson gang manages to slip through their fingers.The Mayor wants Harris and Proctor to work with Police Academy head Commandant Lassard (George Gaynes) on apprehending the gang. Lassard assembles a seven-man team consisting of Hightower (Bubba Smith), Tackleberry (David Graf), Jones (Michael Winslow), Hooks (Marion Ramsey), Callahan (Leslie Easterbrook), Fackler (Bruce Mahler), and Lassard's nephew, Nick (Matt McCoy) who transfers from Miami (in the previous film Police Acdemy 5) to the city to remain close to his friends and dull-witted uncle.After distributing flyers as to the information of the Wilson gang and getting nowhere, Nick McCoy stumbles upon a paper heading of an antique diamond heading to a museum, and gets an idea to use it as bait: however the robbers nab the diamond anyway by cutting a hole in the truck and escaping through the sewer system. McCoy then decides to go undercover to get information regarding a possible hideout, but Harris decides to go undercover to get a confession.It turns out that Harris goes undercover as a window washer at a tall building, for which he has a fear of heights, and gets a confession of himself on tape after his loyal but numb-skull lacky, Proctor, accidentally knocks him over the balcony.It is revealed here that the robberies are committed by a group of three dim-witted criminals who do not seem to be able to do this on their own, and it is revealed they are being guided by a literally shadow figure known as the "Mastermind", who speaks to the three behind a wall of glass and uses a voice distortion device. He devises a plan to get the cops out of the way.Commandant Lassard and his men are later suspended after stolen jewellery from the last robbery is planted in Lassard's locker, pending an investigation. The misfit cops decide to clear Lassard's name by nabbing the gang and the ringleader. Accessing data files from a computer, McCoy deduces that the robberies are occurring along a bus route, thus intentionally lowering property values in that part of the city. They also learn that someone must be 'leaking' information to the bad guys, which is why they are always one step ahead of the Police Academy.The Police Academy force finds and does battle with the Wilson gang, while Nick chases the leader. A pursuit follows, which leads to Commissioner Hurst's (George Robertson) office. It is revealed that the Mayor is the "Mastermind" and that Captain Harris has been unwittingly leaking information during his daily meetings with the Mayor. Hurst apologizes and reinstates the force, and a plaque is given to honor the officers' bravery the next day.As the movie closes, Harris is sitting in a chair when a string tying the balloon float is cut, lifting his chair and floating him up into the air as he shouts Proctor's name. 
 Question: Who is revealed to be the "Mastermind"?
Output: mayor
Context: HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. 
 Question: In what living being can HNF1B be found?
Output: human
Context: As of the census of 2000, there were 35,100 people, 12,759 households, and 9,071 families residing in the county. The population density was 59 people per square mile (23/km). There were 15,035 housing units at an average density of 25 per square mile (10/km). The racial makeup of the county was 85.8% Race (United States Census), 3.9% Race (United States Census) or Race (United States Census), 1.8% Race (United States Census), 1.0% Race (United States Census), 0.1% Race (United States Census), 5.0% from Race (United States Census), and 2.4% from two or more races. 8.9% of the population were Race (United States Census) or Race (United States Census) of any race. 14.9% were of German people, 12.6% English people, 11.7% Irish people, 8.8% Italian people and 7.3% United States ancestry according to Census 2000. 93.1% spoke English language and 5.1% Spanish language as their first language. 
 Question: Were there more households or families?
Output: households
Context: Chronic myeloid leukemia (CML) is an uncommon malignancy, the treatment and prognosis of which have dramatically shifted over the last decade. Characterized by a translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, small-molecule tyrosine kinase inhibitors (TKIs) targeted against the oncogenic BCR-ABL fusion protein have changed this once fatal disease into the model of targeted therapy. This article will review the pharmacological and clinical data supporting the use of imatinib and the second-generation TKIs dasatinib and nilotinib, and the novel TKIs bosutinib and ponatinib. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
Output: bcr-abl
Context: Carina Massone Negrone (Bogliasco, 20 June 1911 - Bogliasco, 19 March 1991) was an Italian aviator. 
 Question: Which city was the birthplace of Carina Massone Negrone?
Output: bogliasco
Context: The homeground of FC Kuusysi is Lahden kisapuisto. 
 Question: What is the home arena of FC Kuusysi?
Output: lahden kisapuisto
Context: According to the market research firm SuperData, as of May 2015, the global games market was worth USD 74.2 billion. By region, North America accounted for $23.6 billion, Asia for $23.1 billion, Europe for $22.1 billion and South America for $4.5 billion. By market segment, mobile games were worth $22.3 billion, retail games 19.7 billion, free-to-play Massively multiplayer online game 8.7 billion, social games $7.9 billion, PC Downloadable content 7.5 billion, and other categories $3 billion or less each. 
 Question: Which market segment was worth less, retail games or social games?
Output: social games