niryuu/sni-each-converted huggingface dataset:
Context: Many genetic disorders are caused by mutations in one or a few genes. Others are caused by chromosomal mutations. Some human genetic disorders are X-linked or Y-linked, which means the faulty gene is carried on these sex chromosomes. Other genetic disorders are carried on one of the other 22 pairs of chromosomes; these chromosomes are known as autosomes or autosomal (non-sex) chromosomes. Some genetic disorders are due to new mutations, others can be inherited from your parents. Some genetic disorders are caused by recessive alleles of a single gene on an autosome. An example of autosomal recessive genetic disorders are Tay-Sachs disease and cystic fibrosis. Children with cystic fibrosis have excessively thick mucus in their lungs, which makes it difficult for them to breathe. The inheritance of this recessive allele is the same as any other recessive allele, so a Punnett square can be used to predict the probability that two carriers of the disease will have a child with cystic fibrosis. Recall that carriers have the recessive allele for a trait but do not express the trait. What are the possible genotypes of the offspring in the following table ( Table 1.1)? What are the possible phenotypes? F FF (normal) Ff (carrier) F f f Ff (carrier) ff (affected) According to this Punnett square, two parents that are carriers (Ff ) of the cystic fibrosis gene have a 25% chance of having a child with cystic fibrosis (ff ). The affected child must inherit two recessive alleles. The carrier parents are not affected. Tay-Sachs disease is a severe genetic disorder in which affected children do not live to adulthood, so the gene is not passed from an affected individual. Carriers of the Tay-Sachs gene are not affected. How does a child become affected with Tay-Sachs? Huntingtons disease is an example of an autosomal dominant disorder. This means that if the dominant allele is present, then the person will express the disease. A child only has to inherit one dominant allele to have the disease. The disease causes the brains cells to break down, leading to muscle spasms and personality changes. Unlike most other genetic disorders, the symptoms usually do not become apparent until middle age. You can use a simple Punnett square to predict the inheritance of a dominant autosomal disorder, like Huntingtons disease. If one parent has Huntingtons disease, what is the chance of passing it on to the children? If you draw the Punnett square, you will find that there is a 50 percent chance of the disorder being passed on to the children. 
 Question: for a child to have cystic fibrosis, the child had to
Output: inherit two recessive alleles.
Context: Rigel Pharmaceuticals Inc is developing fostamatinib, a prodrug of the spleen tyrosine kinase (Syk) inhibitor R-406, for the potential treatment of autoimmune diseases such as rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and B-cell lymphomas. Syk is a key mediator of Fc and B-cell receptor signaling in inflammatory cells, such as B-cells, mast cells, macrophages and neutrophils. Preclinical studies of R-406 or fostamatinib demonstrated a significant reduction in major inflammatory mediators such as TNFalpha, IL-1, IL-6 and IL-18, leading to reduced inflammation and bone degradation in models of RA. In a phase II clinical trial, fostamatinib treatment effectively improved American College of Rheumatology response rates in patients with RA. Preclinical studies and phase II trials also suggested the potential of using fostamatinib for the treatment of ITP and B-cell lymphomas, by increasing platelet counts and inducing response rates, respectively. Fostamatinib is orally bioavailable and was well tolerated in phase I and II trials, with the most common side effect being gastrointestinal symptoms. At the time of publication, phase II trials for fostamatinib were ongoing in patients with RA, ITP and B-cell lymphomas. The Syk inhibitor appears to be a promising therapeutic for immunological diseases, but further data are required to establish the efficacy and long-term safety of the drug in humans. 
 Question: Which enzyme is inhibited by a drug fostamatinib?
Output: spleen tyrosine kinase
Context: Televisions were among the most talked about items at the 2013 International Consumer Electronics Show last week in Las Vegas, Nevada. Some employed the most advanced technology ever. Some of the TVs used a new technology called Organic Light Emitting Diodes, or OLED. They were thinner, lighter, offered better color1 and were brighter than traditional LEDs. Smart TVs this year were smarter. Many offered technology that let users have a more personalized experience. One such TV from the electronics company TCL uses sensors and voice recognition to determine who is watching. It then offers programming based on the specific user. Another TV from Panasonic offers a similar personalized user experience. In addition to television technology, size also played a major part in CES 2013. Televisions varied in size from big to bigger, with at least two companies -- Samsung and HiSense -- exhibiting TVs measuring 110 inches. The yearly Consumer Electronics Show is the biggest technology trade show in North America and one of the biggest in the world. Gary Shapiro is president and CEO of the Consumer Electronics Association, the group that organizes CES. He gave one of the keynote speeches on opening day. "Now you know that CES is more than a trade show. It's a gathering of the brightest minds and the top leaders from many industries and those seeking a glimpse into the future." That glimpse into the future included a look at digital health and fitness devices, which were also big at CES 2013. There were devices that track your activity and others that measure blood pressure, heart rate and weight. There was even a fork that tells you when you are eating too fast. Cars, smart-phones, tablet computers and PCs also made news. And a 27-inch table computer drew quite a bit of attention. CEA President Gary Shapiro says there was much to see but not nearly enough time to see it all. "You cannot see the show in the four days that you have. We have over 3200 different industries showing over 20,000 new products. It's ly incredible." 
 Question: At the 2013 CES, which item drew the most attention?
Output: televisions.
Context: The 49ers would trail 20-13 with less than a minute to go. Blaine Gabbert would run in a game-tying 44 yard touchdown to tie the game at 20. The Bears appeared to have the game won when they went down the field after a decent kick return by Deonte Thompson for 74 yards. Robbie Gould came out to attempt a game-winning 36 yard field goal, but the kick was wide left, resulting in overtime. In the overtime period, Gabbert would throw the game-winning 71-yard touchdown pass to Torrey Smith to win the game for San Francisco. This was San Francisco's first win in Chicago since the 1989 NFC Championship Game. 
 Question: Who threw the longest touchdown pass in overtime?
Output: gabbert
Context: The Jaccard index, also known as the Jaccard similarity coefficient (originally coined coefficient de communaute by Paul Jaccard), is a statistic used for comparing the similarity and diversity of sample sets. 
 Question: Who made Jaccard index known?
Output: paul jaccard
Context: San Francisco kept Detroit in the game with missed opportunities, then made just enough plays for a rare two-game winning streak and its first road win. RB Frank Gore set a franchise record with 148 yards rushing in the first half and scored on a 61-yard run before leaving with a concussion. San Francisco led 13-3 at halftime after scoring on three of its first four drives, wishing it had a bigger lead after out gaining Detroit 247-102 yards and recovering a fumble without giving up a turnover. The 49ers had chances to go ahead big in the third quarter because Detroit had two turnovers on its first three plays, but they came away with only a field goal and a 13-point lead. Gore then caught a 7-yard pass, wobbled off the field and didn't return. QB Alex Smith's fumble midway through the third quarter set up a score that helped the Lions get back in the game. The 49ers drove down the field to set up K Joe Nedney's fourth field goal, a key score because it made Detroit go for a TD instead of kicking a tying field goal late in the game. S Keith Lewis intercepted QB Jon Kitna's pass at the 49ers' 2 with 2 minutes left and San Francisco now 4-5 picked up the one first down it needed to seal the game, winning consecutive games for the second time since 2003. RB Frank Gore finished with career-high 159 yards rushing and San Francisco's QB Alex Smith was 14 of 20 for 136 yards with a fumble. WR Arnaz Battle caught six passes for 55 yards, and converted a third-and-4 on the final drive to allow the 49ers to run out the clock. The 49ers' defense again came up huge, allowing only 273 total offensive yards and forcing 4 turnovers. LB Brandon Moore was yet again the story, leading the team with 9 tackles, 2 sacks and forcing 2 turnovers. With the win, the 49ers advanced to 4-5. 
 Question: Which player had a touchdown before halftime?
Output: frank gore
Context: Phthiriasis palpebrarum is an infestation of the eyelashes caused by the louse Pthirus pubis (Linnaeus, 1758). We report a case of phthiriasis palpebrarum in a 6-year-old girl, which was initially misdiagnosed as allergic blepharoconjunctivitis. Parasites and their nits were found adhering to the eyelashes and eyelids of her right eye as well as scalp hairs. No abnormality was found in the left eye. The histopathology exam revealed the presence of adults and eggs of Pthirus pubis. We mechanically removed all the eyelashes of the right eye at their base, with lice and nits. The scalp was shaved and washed with phenothrin shampoo. No recurrence was found during 3 months of follow-up. Removal of the eyelashes, cutting of scalp hairs, and phenothrin shampoo may be effective in treating phthiriasis palpebrarum. In cases of blepharoconjunctivitis, eyelids and eyelashes should be carefully examined by slit lamp to avoid misdiagnosis. 
 Question: What is the cause of Phthiriasis Palpebrarum?
Output: pthirus pubis
Context: James Sangala (born 20 August 1986) is a Malawian international footballer who plays for Angolan club side Primeiro de Agosto, as a defender. 
 Question: At what position on the field did James Sangala play football?
Output: defender
Context: American Girl It's packed with the things that matter most to girls: party plans, games, crafts and girl-to-girl advice. American Girlis an appealing, age-appropriate teen magazine that allows young girls to be themselves. The magazine features fun contests, puzzles, giggles, and more! Stories, creative games, cool contests and great sports tips for girls aged 7-11 are available in each issue ofAmerican Girl magazine. Issues per year: 6 Cover price: $ 27.95 Sale price: $22.95 Ladybug Beautiful, colorful, and delightful to read, each issue is filled with charming read-aloud stories, games for memory and skill building, songs, poems, and activities for beginning readers. Parents can visit our online Parents Companion that recommends additional activities, crafts, and books. Issues per year: 9 Cover price: $44.50 Sale price: $33.95 Cicada A monthly magazine for teenagers and young adults aged 14 and up. It offers high-quality fiction and poetry dealing with the issue of growing up, leaving the joys and pains of childhood behind, and becoming an adult. Cicadamagazine also encourages its teen readers to submit their own writing for publication. It's so inspiring and humorous that you will not be able to put it down. Issues per year: 6 Cover price: $51.00 Sale price: $33.95 Sorts Illustrated for Kids It covers sports kids like. Featuring interviews with sports heroes, entertaining comics, breathtaking action photos, tips from the pros , news items of recent notes, games, puzzles, cartoons, fiction, advice from athletes, etc.Sports Illustrated for Kidsis a magazine for children aged 8 and up. Issues per year: 12 Cover price: $47.88 Sale price: $ 24.95 
 Question: Which of the four magazines is the most suitable for a 4-year-old child?
Output: ladybug.
Context: The Egyptian Peasant is a book by Henry Habib Ayrout about the life of the Egyptian peasant (fellah). 
 Question: Who was the writer of The Egyptian Peasant?
Output: henry habib ayrout
Context: Coming off their last-second victory over the Bengals, the Broncos would play their Week 2 home opener against the Cleveland Browns. In the first quarter, Denver would trail early as Browns kicker Phil Dawson got a 22-yard field goal. Afterwards, the Broncos took the lead as quarterback Kyle Orton completed a 2-yard touchdown pass to tight end Tony Scheffler. Cleveland would creep close as Dawson made a 47-yard field goal, but Denver would answer as kicker Matt Prater got a 23-yard field goal in the second quarter and a 38-yard field goal in the third quarter. In the fourth, the Broncos pulled away as fullback Peyton Hillis got a 2-yard touchdown run and running back Correll Buckhalter got a 45-yard touchdown run. 
 Question: Which player kicked the second most longest field goal?
Output: matt prater
Context: The RTS,S/AS01(E) candidate malaria vaccine is being developed for immunisation of infants in Africa through the expanded programme on immunisation (EPI). 8 month follow-up data have been reported for safety and immunogenicity of RTS,S/AS01(E) when integrated into the EPI. We report extended follow-up to 19 months, including efficacy results. We did a randomised, open-label, phase 2 trial of safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with EPI vaccines between April 30, 2007, and Oct 7, 2009, in Ghana, Tanzania, and Gabon. Eligible children were 6-10 weeks of age at first vaccination, without serious acute or chronic illness. All children received the EPI diphtheria, tetanus, pertussis (inactivated whole-cell), and hepatitis-B vaccines, Haemophilus influenzae type b vaccine, and oral polio vaccine at study months 0, 1, and 2, and measles vaccine and yellow fever vaccines at study month 7. Participants were randomly assigned (1:1:1) to receive three doses of RTS,S/AS01(E) at 6, 10, and 14 weeks (0, 1, 2 month schedule) or at 6 weeks, 10 weeks, and 9 months (0, 2, 7 month schedule) or placebo. Randomisation was according to a predefined block list with a computer-generated randomisation code. Detection of serious adverse events and malaria was by passive case detection. Antibodies against Plasmodium falciparum circumsporozoite protein and HBsAg were monitored for 19 months. This study is registered with ClinicalTrials.gov, number NCT00436007. 511 children were enrolled. Serious adverse events occurred in 57 participants in the RTS,S/AS01(E) 0, 1, 2 month group (34%, 95% CI 27-41), 47 in the 0, 1, 7 month group (28%, 21-35), and 49 (29%, 22-36) in the control group; none were judged to be related to study vaccination. At month 19, anticircumsporozoite immune responses were significantly higher in the RTS,S/AS01(E) groups than in the control group. Vaccine efficacy for the 0, 1, 2 month schedule (2 weeks after dose three to month 19, site-adjusted according-to-protocol analysis) was 53% (95% CI 26-70; p=00012) against first malaria episodes and 59% (36-74; p=00001) against all malaria episodes. For the entire study period, (total vaccinated cohort) vaccine efficacy against all malaria episodes was higher with the 0, 1, 2 month schedule (57%, 95% CI 33-73; p=00002) than with the 0, 1, 7 month schedule (32% CI 16-45; p=00003). 1 year after dose three, vaccine efficacy against first malaria episodes was similar for both schedules (0, 1, 2 month group, 616% [95% CI 356-771], p<0001; 0, 1, 7 month group, 638% [404-780], p<0001, according-to-protocol cohort). Vaccine efficacy was consistent with the target put forward by the WHO-sponsored malaria vaccine technology roadmap for a first-generation malaria vaccine. The 0, 1, 2 month vaccine schedule has been selected for phase 3 candidate vaccine assessment. Program for Appropriate Technology in Health Malaria Vaccine Initiative; GlaxoSmithKline Biologicals. 
 Question: RTS S AS01 vaccine was developed to prevent which disease?
Output: malaria
Context: Energy travels through space or material. This is obvious when you stand near a fire and feel its warmth or when you pick up the handle of a metal pot even though the handle is not sitting directly on the hot stove. Invisible energy waves can travel through air, glass, and even the vacuum of outer space. These waves have electrical and magnetic properties, so they are called electromagnetic waves. The transfer of energy from one object to another through electromagnetic waves is known as radiation. Different wavelengths of energy create different types of electromagnetic waves (Figure 1.1). The wavelengths humans can see are known as visible light. When viewed together, all of the wavelengths of visible light appear white. But a prism or water droplets can break the white light into different wavelengths so that separate colors appear (Figure 1.2). What objects can you think of that radiate visible light? Two include the Sun and a light bulb. The longest wavelengths of visible light appear red. Infrared wavelengths are longer than visible red. Snakes can see infrared energy. We feel infrared energy as heat. Wavelengths that are shorter than violet are called ultraviolet. Can you think of some objects that appear to radiate visible light, but actually do not? The Moon and the planets do not emit light of their own; they reflect the light of the Sun. Reflection is when light (or another wave) bounces back from a surface. Albedo is a measure of how well a surface reflects light. A surface with high albedo reflects a large percentage of light. A snow field has high albedo. One important fact to remember is that energy cannot be created or destroyed it can only be changed from one form to another. This is such a fundamental fact of nature that it is a law: the law of conservation of energy. In photosynthesis, for example, plants convert solar energy into chemical energy that they can use. They do not create new energy. When energy is transformed, some nearly always becomes heat. Heat transfers between materials easily, from warmer objects to cooler ones. If no more heat is added, eventually all of a material will reach the same temperature. 
 Question: this breaks up light into different wavelengths, separating light into different colors.
Output: prism
Context: Sotos syndrome is an overgrowth syndrome with characteristic facial gestalt and mental retardation of variable severity. Haploinsufficiency of the NSD1 gene has been implicated as the major cause of Sotos syndrome, with a predominance of microdeletions reported in Japanese patients. This study was conducted to investigate into the spectrum of NSD1 gene mutations in southern Chinese patients with Sotos syndrome. Thirty-six Chinese patients with Sotos syndrome and two patients with Weaver syndrome were subject to molecular testing. NSD1 gene mutations were detected in 26 (72%) Sotos patients. Microdeletion was found in only 3 patients, while the other 23 had point mutations (6 frameshift, 8 nonsense, 2 spice site, and 7 missense). Of these, 19 mutations were never reported. NSD1 gene mutations were not found in the two patients with Weaver syndrome. Most cases of Sotos syndrome are caused by NSD1 gene defects, but the spectrum of mutations is different from that of Japanese patients. Genotype-phenotype correlation showed that patients with microdeletions might be more prone to congenital heart disease but less likely to have somatic overgrowth. The two patients with Weaver syndrome were not found to have NSD1 gene mutations, but the number was too small for any conclusion to be drawn. 
 Question: Which gene is responsible for the development of Sotos syndrome?
Output: nsd1 gene
Context: The Redskins scored the first points of the game when Shaun Suisham kicked a 31-yard field goal in the second quarter. On the last play of the 1st half, Trent Green threw a 1-yard pass to Justin Peelle to claim the lead. The Redskins started the third quarter with Clinton Portis running for a 19-yard touchdown. Miami later answered with a field goal to tie the game. In the 4th quarter, both teams scored a field goal and the game went into overtime. Washington won the coin toss. They ran the ball down to Miami's 22-yardline, and Shaun Suisham made a game-winning 39-yard field goal. Clinton Portis finished the game with 17 carries, 98 yards, and a touchdown. The Redskins lost right tackle Jon Jansen for the year when he fractured his ankle in the second quarter. GameBook 
 Question: Which team won the coin toss?
Output: the redskins
Context: The earth is not the only body that travels around the sun. With it are eight other planets, fellow members of the sun's family. Two of them, Mercury and Venus, are nearer while the other six, namely Mars, Jupiter, Saturn, Uranus, Neptune and Pluto, also in their given order from the sun, are farther from the sun than the earth is. The farther they are, the longer trips they make around the sun. People noticed long ago that these traveling bodies moved around in the sky in definite paths. It is a force called gravity that holds them in their paths. We know that every little bit of matter in the universe pulls upon every other bit of matter. The pull between two bodies is proportional to the product of their masses. Because the sun is so large the pull between the sun and the planets are thus great. If it were not for this pull, the planets would fly off into space. In the same way there exists a pull between the earth and the moon, which keeps the moon traveling in its orbit around our planet, the earth. Gravity holds you to its surface, and pulls back to it the ball which you throw into the air. Of course the ball also pulls on the larger earth but the earth is so much larger that the pull is not noticed. Now remember that large bodies exert a greater pull than smaller ones which contain less material. But each object in the universe, no matter how small, pulls on all other objects to some degree. 
 Question: Which two planets make the longest trips around the sun among all the planets in the solar system?
Output: neptune and pluto.
Context: The major protein constituent of Lewy bodies (LBs), the pathological hallmark of Parkinson disease and dementia with Lewy bodies, is considered to be alpha-synuclein, but other proteins, in particular the microtubule-associated protein tau, have been implicated in the pathogenesis of LBs. Tau is the major structural component of neurofibrillary tangles (NFTs). Both direct immunochemical studies of partially purified LBs and indirect immunohistochemical studies have suggested that LBs may contain tau, but most of these studies were based upon a single tau antibody, and immunologic cross-reactivity was not completely excluded. To gain insight into the relation between tau and alpha-synuclein in LBs, double immunostaining was performed in Lewy body cases with a rabbit polyclonal antibody to alpha-synuclein and a panel of monoclonal antibodies to phospho- and nonphospho-tau epitopes (Alz50, CP9, CP13, PG5, TG3, PHFI) that spanned the length of the tau molecule. Tau-immunoreactive LBs were present in the medulla in 80% of the cases, irrespective of Braak stage. All tau antibodies recognized at least some LBs, arguing against nonspecific antibody cross-reactivity. In most lesions the tau immunostaining was present at the periphery of the LB. The phospho-tau antibody, TG3, detected more LBs than any of the other tau antibodies. The proportion of LBs with tau immunoreactivity was greatest in neurons vulnerable to NETs, such as those in the locus ceruleus and basal nucleus of Meynert, and least in neurons resistant to NFTs, such as the dorsal motor nucleus of the vagus in the medulla. The present results suggest that tau may coaggregate with alpha-synuclein in LBs, especially in neuronal populations vulnerable to both NFTs and LBs. 
 Question: Which is the primary protein component of Lewy bodies?
Output: αsyn
Context: The major protein constituent of Lewy bodies (LBs), the pathological hallmark of Parkinson disease and dementia with Lewy bodies, is considered to be alpha-synuclein, but other proteins, in particular the microtubule-associated protein tau, have been implicated in the pathogenesis of LBs. Tau is the major structural component of neurofibrillary tangles (NFTs). Both direct immunochemical studies of partially purified LBs and indirect immunohistochemical studies have suggested that LBs may contain tau, but most of these studies were based upon a single tau antibody, and immunologic cross-reactivity was not completely excluded. To gain insight into the relation between tau and alpha-synuclein in LBs, double immunostaining was performed in Lewy body cases with a rabbit polyclonal antibody to alpha-synuclein and a panel of monoclonal antibodies to phospho- and nonphospho-tau epitopes (Alz50, CP9, CP13, PG5, TG3, PHFI) that spanned the length of the tau molecule. Tau-immunoreactive LBs were present in the medulla in 80% of the cases, irrespective of Braak stage. All tau antibodies recognized at least some LBs, arguing against nonspecific antibody cross-reactivity. In most lesions the tau immunostaining was present at the periphery of the LB. The phospho-tau antibody, TG3, detected more LBs than any of the other tau antibodies. The proportion of LBs with tau immunoreactivity was greatest in neurons vulnerable to NETs, such as those in the locus ceruleus and basal nucleus of Meynert, and least in neurons resistant to NFTs, such as the dorsal motor nucleus of the vagus in the medulla. The present results suggest that tau may coaggregate with alpha-synuclein in LBs, especially in neuronal populations vulnerable to both NFTs and LBs. 
 Question: Which is the primary protein component of Lewy bodies?
Output: α-synuclein
Context: The major protein constituent of Lewy bodies (LBs), the pathological hallmark of Parkinson disease and dementia with Lewy bodies, is considered to be alpha-synuclein, but other proteins, in particular the microtubule-associated protein tau, have been implicated in the pathogenesis of LBs. Tau is the major structural component of neurofibrillary tangles (NFTs). Both direct immunochemical studies of partially purified LBs and indirect immunohistochemical studies have suggested that LBs may contain tau, but most of these studies were based upon a single tau antibody, and immunologic cross-reactivity was not completely excluded. To gain insight into the relation between tau and alpha-synuclein in LBs, double immunostaining was performed in Lewy body cases with a rabbit polyclonal antibody to alpha-synuclein and a panel of monoclonal antibodies to phospho- and nonphospho-tau epitopes (Alz50, CP9, CP13, PG5, TG3, PHFI) that spanned the length of the tau molecule. Tau-immunoreactive LBs were present in the medulla in 80% of the cases, irrespective of Braak stage. All tau antibodies recognized at least some LBs, arguing against nonspecific antibody cross-reactivity. In most lesions the tau immunostaining was present at the periphery of the LB. The phospho-tau antibody, TG3, detected more LBs than any of the other tau antibodies. The proportion of LBs with tau immunoreactivity was greatest in neurons vulnerable to NETs, such as those in the locus ceruleus and basal nucleus of Meynert, and least in neurons resistant to NFTs, such as the dorsal motor nucleus of the vagus in the medulla. The present results suggest that tau may coaggregate with alpha-synuclein in LBs, especially in neuronal populations vulnerable to both NFTs and LBs. 
 Question: Which is the primary protein component of Lewy bodies?
Output: alpha-synuclein
Context: Born in Belfast, Northern Ireland, the son of Thomas Megahey (a minister) and Beatrice (nee Walton), Leslie Megahey was educated at King Edward VI School in Lichfield. 
 Question: Which college or university is related with Leslie Megahey?
Output: king edward vi school
Context: Scores of people queued up to use a cash machine after it started giving out double the money requested. The cash machine, outside a Sainsbury's store in Barham Road, Hull, attracted a big crowd of people hoping to take advantage of the fault, on Tuesday night. Police officers were eventually sent in to guard the machine and prevent anymore money from being withdrawn. The fault is thought to have affected cash machines at supermarkets across the city. It is not yet known whether the customers will have to repay the cash or how much money was taken out. A spokeswoman for Humberside Police said, "Officers were sent to the cash machine to prevent anyone else from withdrawing anymore money. We have also tried to make contact with the owners of the machine." The spokeswoman said those who benefited from the fault could be traced and could face theft charges, but investigations would only take place if the operator made a complaint. The cash machine is owned by a company called Payzone, a spokesman later confirmed. He said the fault was due to the machine being filled with notes of the wrong denomination . An investigation is underway into the incident and the machine had been taken out of service, he added. The Payzone spokesman said, "The transit company which is contracted to service this ATM has filled it up with the wrong denomination of notes, meaning it is paying out double what it should have. " He could not say how much money had been taken out of the machine, or whether it would have to be paid back. It was understood that a number of cash machines in Hull owned by other companies had also been affected by this problem, he added. 
 Question: Who caused the cash machine not to work properly?
Output: the transit company.
Context: Activation of the non-phagocytic superoxide-producing NADPH oxidase Nox1, complexed with p22(phox) at the membrane, requires its regulatory soluble proteins Noxo1 and Noxa1. However, the role of the small GTPase Rac remained to be clarified. Here we show that Rac directly participates in Nox1 activation via interacting with Noxa1. Electropermeabilized HeLa cells, ectopically expressing Nox1, Noxo1, and Noxa1, produce superoxide in a GTP-dependent manner, which is abrogated by expression of a mutant Noxa1(R103E), defective in Rac binding. Superoxide production in Nox1-expressing HeLa and Caco-2 cells is decreased by depletion or sequestration of Rac; on the other hand, it is enhanced by expression of the constitutively active Rac1(Q61L), but not by that of a mutant Rac1 with the A27K substitution, deficient in binding to Noxa1. We also demonstrate that Nox1 activation requires membrane recruitment of Noxa1, which is normally mediated via Noxa1 binding to Noxo1, a protein tethered to the Nox1 partner p22(phox): the Noxa1-Noxo1 and Noxo1-p22(phox) interactions are both essential for Nox1 activity. Rac likely facilitates the membrane localization of Noxa1: although Noxa1(W436R), defective in Noxo1 binding, neither associates with the membrane nor activates Nox1, the effects of the W436R substitution are restored by expression of Rac1(Q61L). The Rac-Noxa1 interaction also serves at a step different from the Noxa1 localization, because the binding-defective Noxa1(R103E), albeit targeted to the membrane, does not support superoxide production by Nox1. Furthermore, a mutant Noxa1 carrying the substitution of Ala for Val-205 in the activation domain, which is expected to undergo a conformational change upon Rac binding, fully localizes to the membrane but fails to activate Nox1. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nadph oxidase 1
Context: Activation of the non-phagocytic superoxide-producing NADPH oxidase Nox1, complexed with p22(phox) at the membrane, requires its regulatory soluble proteins Noxo1 and Noxa1. However, the role of the small GTPase Rac remained to be clarified. Here we show that Rac directly participates in Nox1 activation via interacting with Noxa1. Electropermeabilized HeLa cells, ectopically expressing Nox1, Noxo1, and Noxa1, produce superoxide in a GTP-dependent manner, which is abrogated by expression of a mutant Noxa1(R103E), defective in Rac binding. Superoxide production in Nox1-expressing HeLa and Caco-2 cells is decreased by depletion or sequestration of Rac; on the other hand, it is enhanced by expression of the constitutively active Rac1(Q61L), but not by that of a mutant Rac1 with the A27K substitution, deficient in binding to Noxa1. We also demonstrate that Nox1 activation requires membrane recruitment of Noxa1, which is normally mediated via Noxa1 binding to Noxo1, a protein tethered to the Nox1 partner p22(phox): the Noxa1-Noxo1 and Noxo1-p22(phox) interactions are both essential for Nox1 activity. Rac likely facilitates the membrane localization of Noxa1: although Noxa1(W436R), defective in Noxo1 binding, neither associates with the membrane nor activates Nox1, the effects of the W436R substitution are restored by expression of Rac1(Q61L). The Rac-Noxa1 interaction also serves at a step different from the Noxa1 localization, because the binding-defective Noxa1(R103E), albeit targeted to the membrane, does not support superoxide production by Nox1. Furthermore, a mutant Noxa1 carrying the substitution of Ala for Val-205 in the activation domain, which is expected to undergo a conformational change upon Rac binding, fully localizes to the membrane but fails to activate Nox1. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nicotinamide adenine dinucleotide phosphate-oxidase 1
Context: Activation of the non-phagocytic superoxide-producing NADPH oxidase Nox1, complexed with p22(phox) at the membrane, requires its regulatory soluble proteins Noxo1 and Noxa1. However, the role of the small GTPase Rac remained to be clarified. Here we show that Rac directly participates in Nox1 activation via interacting with Noxa1. Electropermeabilized HeLa cells, ectopically expressing Nox1, Noxo1, and Noxa1, produce superoxide in a GTP-dependent manner, which is abrogated by expression of a mutant Noxa1(R103E), defective in Rac binding. Superoxide production in Nox1-expressing HeLa and Caco-2 cells is decreased by depletion or sequestration of Rac; on the other hand, it is enhanced by expression of the constitutively active Rac1(Q61L), but not by that of a mutant Rac1 with the A27K substitution, deficient in binding to Noxa1. We also demonstrate that Nox1 activation requires membrane recruitment of Noxa1, which is normally mediated via Noxa1 binding to Noxo1, a protein tethered to the Nox1 partner p22(phox): the Noxa1-Noxo1 and Noxo1-p22(phox) interactions are both essential for Nox1 activity. Rac likely facilitates the membrane localization of Noxa1: although Noxa1(W436R), defective in Noxo1 binding, neither associates with the membrane nor activates Nox1, the effects of the W436R substitution are restored by expression of Rac1(Q61L). The Rac-Noxa1 interaction also serves at a step different from the Noxa1 localization, because the binding-defective Noxa1(R103E), albeit targeted to the membrane, does not support superoxide production by Nox1. Furthermore, a mutant Noxa1 carrying the substitution of Ala for Val-205 in the activation domain, which is expected to undergo a conformational change upon Rac binding, fully localizes to the membrane but fails to activate Nox1. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Output: nox1
Context: Lynd was one of two children born to the renowned sociologists Robert Staughton Lynd and Helen Lynd, who authored the groundbreaking ''Middletown'' studies of Muncie, Indiana, in the late 1920s and '30s. 
 Question: Which lady Staughton Lynd was born to?
Output: helen lynd
Context: Chaperone-mediated autophagy (CMA) is a selective autophagy-lysosome protein degradation pathway. The role of CMA in normal neuronal functions and in neural disease pathogenesis remains unclear, in part because there is no available method to monitor CMA activity at the single-cell level. We sought to establish a single-cell monitoring method by visualizing translocation of CMA substrates from the cytosol to lysosomes using the HaloTag (HT) system. GAPDH, a CMA substrate, was fused to HT (GAPDH-HT); this protein accumulated in the lysosomes of HeLa cells and cultured cerebellar Purkinje cells (PCs) after labeling with fluorescent dye-conjugated HT ligand. Lysosomal accumulation was enhanced by treatments that activate CMA and prevented by siRNA-mediated knockdown of LAMP2A, a lysosomal receptor for CMA, and by treatments that inactivate CMA. These results suggest that lysosomal accumulation of GAPDH-HT reflects CMA activity. Using this method, we revealed that mutant PKC, which causes spinocerebellar ataxia type 14, decreased CMA activity in cultured PCs. In the present study, we established a novel fluorescent-based method to evaluate CMA activity in a single neuron. This novel method should be useful and valuable for evaluating the role of CMA in various neuronal functions and neural disease pathogenesis. 
 Question: Which is the receptor for substrates of Chaperone Mediated Autophagy?
Output: lamp2a
Context: Chaperone-mediated autophagy (CMA) is a selective autophagy-lysosome protein degradation pathway. The role of CMA in normal neuronal functions and in neural disease pathogenesis remains unclear, in part because there is no available method to monitor CMA activity at the single-cell level. We sought to establish a single-cell monitoring method by visualizing translocation of CMA substrates from the cytosol to lysosomes using the HaloTag (HT) system. GAPDH, a CMA substrate, was fused to HT (GAPDH-HT); this protein accumulated in the lysosomes of HeLa cells and cultured cerebellar Purkinje cells (PCs) after labeling with fluorescent dye-conjugated HT ligand. Lysosomal accumulation was enhanced by treatments that activate CMA and prevented by siRNA-mediated knockdown of LAMP2A, a lysosomal receptor for CMA, and by treatments that inactivate CMA. These results suggest that lysosomal accumulation of GAPDH-HT reflects CMA activity. Using this method, we revealed that mutant PKC, which causes spinocerebellar ataxia type 14, decreased CMA activity in cultured PCs. In the present study, we established a novel fluorescent-based method to evaluate CMA activity in a single neuron. This novel method should be useful and valuable for evaluating the role of CMA in various neuronal functions and neural disease pathogenesis. 
 Question: Which is the receptor for substrates of Chaperone Mediated Autophagy?
Output: lysosome-associated membrane protein 2 isoform a
Context: In week 4, the Lions traveled across Lake Michigan to Green Bay, Wisconsin to play division rivals the Green Bay Packers. The Packers started the scoring in the first quarter with a 29-yard TD catch by Donald Driver from Aaron Rodgers. The Lions tied it up in the second quarter with a 23-yard TD catch by Calvin Johnson. The Packers took the lead with a 13-yard catch by Jermichael Finley. They added to their lead 17-yard catch by Greg Jennings. The Lions responded just before halftime with a 21-yard catch by Calvin Johnson. Just after the break, the Packers' Charles Woodson returned an interception for a touchdown. The Lions attempted a comeback with 4 consecutive field goals: from 39 yards and 52 yards in the 3rd quarter, and later from 49 yards and 24 yards in the 4th. With the loss, not only did the Lions fall to 0-4, but it also marked their 19th consecutive loss in Wisconsin. 
 Question: What was the Lions record after week 4?
Output: 0-4,
Context: The L.A. Quartet is a sequence of four crime fiction novels by James Ellroy set in the late 1940s through the late 1950s in Los Angeles. 
 Question: Which place is L.A. Quartet in?
Output: los angeles
Context: On 2 April 1953, OTCM order #34765 standardized the last of the Patton series tanks as the 90mm Gun Tank M48 Patton. 
 Question: What was the year that M48 Patton entered service?
Output: 1953
Context: The Neumeister Collection is a manuscript compilation of chorale preludes for organ assembled by Johann Gottfried Neumeister (1757--1840) after 1790, including 31 compositions by Johann Sebastian Bach (BWV 1090--1120) that were uncatalogued until scholars rediscovered the manuscript in the 1980s. 
 Question: Which musical instrument is connected with Neumeister Collection?
Output: organ
Context: It's the dieting fashion that is sweeping the world, and encourages fasting for two days of the week. But does it work? People are starving themselves to lose weight, with a dieting trend known as the "fast diet" growing in popularity. The method is also known as the 5:2 diet, and consists of eating normally for five days of a week and cutting calories to about 25 percent of normal intake during other two days. Men consume just 600 calories on the two fast days, while women are limited to 500 calories. Notably, the two fasting days should not be _ . The dieter should have at least one normal eating day in between. In the best-selling book The Fast Diet: Lose Weight, Stay Healthy, and Live Longer with the Simple Secret of Intermittent Fasting by Dr. Michael Mosley and Mimi Spencer, the two authors claim that the 5:2 diet not only promotes weight loss, but also benefits health, offering protection from disease, improved cognitive function and increased lifespan. The diet originated in the United Kingdom and became popular in the United States. Now, it is gaining popularity among the Chinese middle-class. Zhong Minghui, who is 178 cm tall and used to weigh 100 kilograms, finds fasting effective in weight control. He works in the sales department of a trade company and used to drink and eat a lot after work. After sticking to the fasting diet for five months, he managed to lose about 20 kilograms. "Actually I did not exactly rely on the 5:2 diet to lose weight. My fasting was more extreme. I almost completely cut off my supper every day and only ate some fruit. I also used an app to calculate the calories in the food I ate and was cautious of not eating any high-calorie food. I did about an hour's aerobic exercise every day. Fasting is definitely effective, but I think sports also help," he says. "I do not really believe that fasting is the magical cure-all , but my high blood sugar has improved," he adds. The US Academy of Nutrition and Dietetics says that although there is evidence that intermittent fasting diets may help prevent chronic disease, more research is needed. Han Ting, a clinic nutritionist of Shanghai Tenth People's Hospital, says that people who suffer diabetes or eating disorders, pregnant women, kids, teens and frail seniors should not try fasting. She recommends a regular low-calorie diet, which is safer and less risky for health. When on a fasting diet, on the weekly fasting days, Han recommends low-fat, low-sugar, and low-protein food, such as vegetables, yogurt, non-fat milk, shellfish and fruits with high dietary fiber . 
 Question: Which is the best title of the passage?
Output: fast diet
Context: Selenocysteine, a selenium-containing analog of cysteine, is found in the prokaryotic and eukaryotic kingdoms in active sites of enzymes involved in oxidation-reduction reactions. Its biosynthesis and cotranslational insertion into selenoproteins is performed by an outstanding mechanism, implying the participation of several gene products. The tRNA(Sec) is one of these. In eukaryotes, its transcription mode by RNA polymerase III differs from that of classical tRNA genes, both at the level of the promoter elements and transcription factors involved. In addition, enhanced transcription is afforded by a newly characterized zinc finger activator. Not only transcription of the gene, but also the tRNA(Sec) itself is atypical since its 2D and 3D structures exhibit features which set it apart from classical tRNAs. Decoding of eukaryotic selenocysteine UGA codons requires a stem-loop structure in the 3'UTR of mRNAs, the selenocysteine insertion sequence (SECIS) element. Structure probing and sequence comparisons led us to propose a 2D structure model for the SECIS element, containing a novel RNA motif composed of four consecutive non-Watson-Crick base-pairs. A 3D model, rationalizing the accessibility data, was elaborated by computer modeling. It yields indicative or suggestive evidence for the role that could play some conserved residues and/or structural features in SECIS function. These might act as signals for interaction with SBP, the SECIS binding protein that we have characterized. 
 Question: What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
Output: secis
Context: The Ehlers-Danlos syndromes (EDS) are a group of heritable connective tissue disorders that share the common features of skin hyperextensibility, articular hypermobility, and tissue fragility. Considerable clinical and genetic heterogeneity exists, and more than nine separate forms have been recognized. Recent advances in the molecular analysis of EDS have identify defects responsible for EDS VI (homozygous and compound heterozygous mutations in the lysyl-hydroxylase gene), EDS VIIA and EDS VIIB (mutations in the type I collagene genes), EDS VIIC (deficiency of procollagen N-proteinase), EDS IX (mutations in the MNK gene), and EDS IV (mutations in the type III collagen gene). Of the various types of Ehlers-Danlos syndrome the most severe is type IV (EDS IV). Early studies showed that fibroblasts from EDS IV patients secreted lower than normal amounts of type III procollagen (Pope et al., 1975). Later, the disease was linked to COL3A1, the gene encoding this protein. More recently, with the publication of full length cDNA and partial characterisation of the gene structure, detailed analysis of mutations in EDS IV patients has become possible. Nineteen different mutations in the type III procollagen gene have been reported in different families with EDS IV. Recent results support the hypothesis that in EDS IV, dominant inheritance should be assumed, in sporadic cases also, unless proven otherwise. Very little is known about the genetics or biochemicals defects responsible for the others EDS subtypes, but with the applications of the tools of molecular biology, analysis of these defects if now within reach. 
 Question: What tissue is most affected in Ehlers-Danlos syndromes?
Output: connective tissue
Context: Hoping to rebound from their home loss to the Titans, the Bears flew to Lambeau Field for a Week 11 NFC North duel with their hated rival, the Green Bay Packers. In the first quarter, Chicago trailed early as Packers QB Aaron Rodgers completed a 3-yard TD pass to WR Greg Jennings. In the second quarter, the Bears got on the board with kicker Robbie Gould getting a 35-yard field goal. Green Bay would answer with RB Ryan Grant getting a 4-yard TD run, along with kicker Mason Crosby getting a 53-yard field goal. In the third quarter, Chicago continued to trail as Rodgers completed a 5-yard TD pass to TE Donald Lee. In the fourth quarter, the Packers pulled away as Crosby made a 33-yard field goal, DE Jason Hunter returned a fumble 54 yards for a touchdown, and Crosby nailing a 45-yard field goal. 
 Question: Who threw the longest TD pass?
Output: aaron rodgers