Question: What year was the first case of HIV/AIDS reported? Passage 1:He was then cast as Edward Mapplethorpe in the 2018 biographical drama film Mapplethorpe, which follows the life of New York photographer Robert Mapplethorpe. It screened at Tribeca Film Festival in 2018 where it was named a Runner-up in the U.S. Narrative Competition section. Sklenar received positive critical acclaim from multiple media outlets for his performance in Mapplethorpe, including from Boy Culture who praised him for "[having] maximum impact in [his] psychologically charged scenes with [Matt] Smith" and Screen Daily who said:"As the brother and photographer Edward Mapplethorpe, who Robert [Mapplethorpe] forced to change his name, Brandon Sklenar is a fragile mix of awe and fear." He appeared in the 2018 biographical drama film Vice, opposite Amy Adams, Steve Carell, Christian Bale and Sam Rockwell. The film explores the life of politician Dick Cheney and is directed by Academy Award-winner Adam McKay. Sklenar will appear in Amir Naderi's upcoming film Magic Lantern, in addition to films The Last Room and Glass Jaw. In June 2018, Sklenar was also cast in the independent drama film Indigo Valley, which is based on director Jaclyn's Bethany's short film of the same name. That same year, Sklenar was cast in a lead role in London Calling, a noir crime thriller that weaves the British gangster genre with the American western, opposite Ron Perlman, Malcolm McDowell, Nicholas Braun and Leven Rambin.
 Passage 2:While working at the National Institute of Health, Lisziewicz worked to find a gene therapy approach to treat HIV/AIDS. She based her research on discovering if small portions of gene-stopping DNA (called antisense oligonucleotides) could be created to bind up the viral RNA in retroviruses like HIV so that the virus could not make more copies of itself to continue the infection. Small pieces of messenger RNA (or mRNA) carry a copy of the cell's DNA to the ribosomes where the mRNA directs the ribosomes to create the proteins that the cells need. Viruses (like HIV) have their own set of mRNA, and they use the ribosomes of the cell they infected to make new viruses to propagate the infection throughout the body. Lisziewicz's idea was to create antisense oligonucleotides that are complementary to the HIV's viral mRNA. These complementary DNA pieces can bind to the HIV viral mRNA and prevent the HIV virus from replicating itself. The use of antisense oligonucleotides worked very well in cell cultures, and was quickly transferred to clinical trials.
 Passage 3:HMS Defender was a D-class destroyer built for the Royal Navy in the early 1930s. The ship was initially assigned to the Mediterranean Fleet before she was transferred to the China Station in early 1935. She was temporarily deployed in the Red Sea during late 1935 during the Abyssinia Crisis, before returning to her assigned station where she remained until mid-1939. Defender was transferred back to the Mediterranean Fleet just before World War II began in September 1939. She briefly was assigned to West Africa for convoy escort duties in 1940 before returning to the Mediterranean. The ship participated in the Battles of Calabria, Cape Spartivento, and Cape Matapan over the next year without damage. Defender assisted in the evacuations from Greece and Crete in April–May 1941, before she began running supply missions to Tobruk, Libya in June. The ship was badly damaged by a German bomber on one of those missions and had to be scuttled by her consort on 11 July 1941.

Output: 2