Question: What is the difference between the two melanocortin receptors? Passage 1:The main party left England by sea on 20 January 1933, stopping at Gibraltar, where the Rock of Gibraltar "offered a climbing problem or two", and Aden. Time at sea was spent discussing the problem of climbing Mount Everest and the establishment of the various camps on its northern side, as well as learning the Nepali language, in which Crawford was proficient. The party alighted at Bombay, where they were assisted by C. E. Boreham, the manager of the Army and Navy Stores. Ruttledge, an India hand, took them on sightseeing tours to Agra and Fatehpur Sikri. Passing through Calcutta, where they were entertained by the Governor of Bengal, Sir John Anderson, the expedition members proceeded to Darjeeling, where Smythe, Greene and Birnie joined them, while Ruttledge went to Siliguri to rendezvous with Shebbeare and discuss transport arrangements. At Darjeeling porters were selected for the march, Ruttledge's Sherpas from his 1932 trip, Nima Dorje and Sanam Topgye, having gone to Sola Khombu to alert prospective applicants to the existence of the British expedition. Llakpar Chedi, Lewa and Nursang were selected as sirdars. In addition, Nima Tendrup, a veteran of many expeditions to Mount Everest, as well as a number of Sherpas who had been on the recent German expeditions to Kangchenjunga, were brought along. Karma Paul, who had been on the 1922 and 1924 British expeditions, was taken as interpreter. All the porters were screened at the Darjeeling hospital, 34 per cent being found to be infected with internal parasites, and then clothed in blue-and-white striped pyjamas and given numbered identity disks.
 Passage 2:AGRP has been demonstrated to be an inverse agonist of melanocortin receptors, to be specific MC3-R and MC4-R. The melanocortin receptors, MC3-R and MC4-R, are directly linked to metabolism and body weight control. These receptors are activated by the peptide hormone α-MSH (melanocyte-stimulating hormone) and antagonized by the agouti-related protein. Whereas α-MSH acts broadly on most members of the MCR family (with the exception of MC2-R), AGRP is highly specific for only MC3-R and MC4-R. This inverse agonism not only antagonizes the action of melanocortin agonists such as α-MSH but also further decreases the cAMP produced by the affected cells. The exact mechanism by which AgRP inhibits melanocortin-receptor signalling is not completely clear. It has been suggested that Agouti-related protein binds MSH receptors and acts as a competitive antagonist of ligand binding. Studies of Agouti protein in B16 melanoma cells supported this logic. The expression of AgRP in the adrenal gland is regulated by glucocorticoids. The protein blocks α-MSH-induced secretion of corticosterone.
 Passage 3:Carlito Guansing Galvez, Jr. is a retired Filipino general and the former Chief of Staff of the Armed Forces of the Philippines. He is a graduate of the Philippine Military Academy "Sandiwa" Class of 1985. He is also known for his leadership of the AFP Western Mindanao Command during the Battle of Marawi. He is a recipient of the United States Eisenhower Fellowships in 2006 and worked on the peace process with the Moro Islamic Liberation Front in 2015 as co-Chairman on the Coordinating Committee on the Cessation of Hostilities (CCCH). He also commanded the Army 104th Brigade, and the 6th Infantry Division. He,then an Army Lieutenant, along with some PMA 1985 classmates, including Rolando Joselito Bautista was also granted amnesty from Former AFP Chief and President Fidel Ramos, during the 1989 Coup.

Output: 2