Question: What areas were affected by the tornado outbreak in 2008? Passage 1:While working at the National Institute of Health, Lisziewicz worked to find a gene therapy approach to treat HIV/AIDS. She based her research on discovering if small portions of gene-stopping DNA (called antisense oligonucleotides) could be created to bind up the viral RNA in retroviruses like HIV so that the virus could not make more copies of itself to continue the infection. Small pieces of messenger RNA (or mRNA) carry a copy of the cell's DNA to the ribosomes where the mRNA directs the ribosomes to create the proteins that the cells need. Viruses (like HIV) have their own set of mRNA, and they use the ribosomes of the cell they infected to make new viruses to propagate the infection throughout the body. Lisziewicz's idea was to create antisense oligonucleotides that are complementary to the HIV's viral mRNA. These complementary DNA pieces can bind to the HIV viral mRNA and prevent the HIV virus from replicating itself. The use of antisense oligonucleotides worked very well in cell cultures, and was quickly transferred to clinical trials.
 Passage 2:A deadly tornado outbreak struck portions of the Lower Mississippi River Valley and the Southeastern United States on February 21–22, 1971. The two-day outbreak produced at least 19 tornadoes, and probably several more, mostly brief events in rural areas; killed 123 people across three states; and "virtually leveled" entire communities in the state of Mississippi. Three violent, long-lived tornadoes—two of which may have been tornado families—in western Mississippi and northeastern Louisiana caused most of the deaths along of path. One of the tornadoes attained F5 intensity in Louisiana, the only such event on record in the state. The outbreak also generated strong tornadoes from Texas to Ohio and North Carolina. The entire outbreak is the second deadliest ever in February, behind only the Enigma tornado outbreak in 1884 and ahead of the 2008 Super Tuesday tornado outbreak. February 21 was the fourth-deadliest day for tornadoes in Mississippi on record. At one point, the National Weather Service WSR-57 radar in Jackson, Mississippi, reported four hook echoes, often indicative of tornado-producing supercells, simultaneously.
 Passage 3:He was then cast as Edward Mapplethorpe in the 2018 biographical drama film Mapplethorpe, which follows the life of New York photographer Robert Mapplethorpe. It screened at Tribeca Film Festival in 2018 where it was named a Runner-up in the U.S. Narrative Competition section. Sklenar received positive critical acclaim from multiple media outlets for his performance in Mapplethorpe, including from Boy Culture who praised him for "[having] maximum impact in [his] psychologically charged scenes with [Matt] Smith" and Screen Daily who said:"As the brother and photographer Edward Mapplethorpe, who Robert [Mapplethorpe] forced to change his name, Brandon Sklenar is a fragile mix of awe and fear." He appeared in the 2018 biographical drama film Vice, opposite Amy Adams, Steve Carell, Christian Bale and Sam Rockwell. The film explores the life of politician Dick Cheney and is directed by Academy Award-winner Adam McKay. Sklenar will appear in Amir Naderi's upcoming film Magic Lantern, in addition to films The Last Room and Glass Jaw. In June 2018, Sklenar was also cast in the independent drama film Indigo Valley, which is based on director Jaclyn's Bethany's short film of the same name. That same year, Sklenar was cast in a lead role in London Calling, a noir crime thriller that weaves the British gangster genre with the American western, opposite Ron Perlman, Malcolm McDowell, Nicholas Braun and Leven Rambin.

Output: 2