Question: How many years ago was the unique sugar sulfamate drug invented by Maryanoff approved for medical use in the U.S.? Passage 1:Benfica's first competitive game was an away Primeira Liga opener against Rio Ave. Sánchez Flores did not have Reyes, and Jonathan Urretaviscaya started instead. At the Estádio dos Arcos, the home team scored first with a 55th-minute goal from José Semedo. A minute later Benfica evened the score, with Urreta assisting Nuno Gomes for the 1–1 final result. It was the fourth consecutive time that Benfica failed to win their league start. Sánchez Flores said that Rio Ave created unexpected problems: "It was not a easy game. We had a quality opponent, who left us trailing when we were not expecting it." During the last week of August Benfica brought in Honduran striker David Suazo on loan, sold right-back Nélson Marcos to Betis and was paired with Italian side Napoli in the UEFA Cup first-round draw on 29 August. A day later, Benfica hosted Porto for the first Clássico of the season. The visitors started better, converting a 10th-minute penalty kick for a Kostas Katsouranis foul against Lucho González. In the 56th minute, Cardozo exploited a mistake by Helton to head in the equaliser. Three minutes later Katsouranis was sent off, but Benfica held the tie until the final whistle. Quique Flores said, "It was a good game. In normal conditions we would have done better, but circumstances made it a little harder."
 Passage 2:Maryanoff has been active in the fields of medicinal chemistry and organic chemistry. He is an inventor of topiramate, a unique sugar sulfamate drug, which has been marketed worldwide for the treatment of epilepsy and migraine, attaining annual sales of more than $2 billion. Topiramate is also a principal component of the antiobesity drug Qsymia. Maryanoff is an internationally renowned expert in drug design and drug discovery, especially in the application of protein structure-based drug design. He made seminal contributions to understanding the stereochemistry and mechanism of the Wittig reaction; adapted the cobalt-catalyzed alkyne trimerization to the synthesis of macrocycles; and devised novel peptides that undergo self-assembly to mimic native collagen structurally and functionally. Maryanoff is an author on 280 scientific publications, including several books (editor), book chapters, and review articles. He is an inventor on 100 issued U.S. patents, has presented over 185 invited lectures worldwide, and mentored 11 postdoctoral associates. Maryanoff organized and edited a special memorial issue of the Journal of Medicinal Chemistry to honor the memory of Dr. Paul Janssen (2005) and has served on numerous editorial advisory boards for scientific journals and research grant review committees.
 Passage 3:The Land of Ev is a fictional country in the Oz books of L. Frank Baum and his successors. Its exact location is unclear between text and maps. The Road to Oz states that Ev is to the north of the Land of Oz, and in Ozma of Oz, Princess Ozma of Oz and her procession enter the Munchkin Country and meet the King of the Munchkins upon leaving the palace at Evna, the capital city. Subsequent books place Ev nearer to the Winkie Country, and the map on the endpapers of Tik-Tok of Oz shows the Munchkin Country as having no northern border with the desert that surrounds Oz, as a thin strip of the Gillikin Country extends even farther east than most of the Munchkin Country. This map depicts Ev as a small country to the northwest (the compass rose is reversed) of Oz, with the Dominions of the Nome King as a separate area. James E. Haff and Dick Martin's map, following the text, place the Nome Kingdom under an Ev that takes up the entire portion allotted to the Nome King's dominions on Baum's map.

Output: 2