Question: Which SFO productions that Li were involved with made the most money? Passage 1:In 1809, Walter Coffin sunk the first coal pit in the Rhondda, further up the valley in Dinas, but a lack of a transportation network greatly affected the profitability of coal mining as an industry in the region. Coffin tackled this problem by constructing a one-mile tramline which connected his mines in Dinas to a tramline built by Dr. Richard Griffiths at Denia (Pontypridd), which linked to a private canal that joined onto the Glamorganshire Canal at Treforest. Coffins tramline followed the southern bank of the River Rhondda and ran through Porth. The existence of the tramline made the development of the Porth and Cymmer region far more attractive, and by the middle of the 19th century there was an impetus to expand coal mining in the area. In 1841 Richard Lewis joined Coffin in trying to exploit the region with his level built at Cymmer. This resulted in the construction of around fifty miners' cottages, several of which were located in Porth. In 1844 Lewis Edwards of Newport and George Gethin of Penygraig opened a small level at Nyth-bran on the eastern borders of Porth, the villages' first coal mine. This was followed in 1845 by the sinking of the Porth Colliery by David James of Merthyr, the success of which saw him build the Llwyncelyn Colliery in 1951, also in Porth. By 1850 the Taff Vale Railway had been extended to Cymmer replacing the tramline, allowing direct access between the lower Rhondda and the ports of Cardiff.
 Passage 2:As a young professor at UC Davis, Deamer continued to work with electron microscopy, revealing for the first time particles related to functional ATPase enzymes within the membranes of sarcoplasmic reticulum. After spending sabbaticals in England at the University of Bristol in 1971 and with Alec Bangham in 1975, Deamer became interested in liposomes. Conversations with Bangham inspired his research on the role of membranes in the origin of life, and in 1985 Deamer demonstrated that the Murchison carbonaceous meteorite contained lipid-like compounds that could assemble into membranous vesicles. Deamer described the significance of self-assembly processes in his 2011 book First Life. In collaborative work with Mark Akeson, a post-doctoral student at the time, the two established methods for monitoring proton permeation through ion channels such as gramicidin. In 1989, while returning from a scientific meeting in Oregon, Deamer conceived that it might be possible to sequence single molecules of DNA by using an imposed voltage to pull them individually through a nanoscopic channel. The DNA sequence could be distinguished by the specific modulating effect of the four bases on the ionic current through the channel. In 1993, he and Dan Branton initiated a research collaboration with John Kasianowitz at NIST to explore this possibility with the hemolysin channel, and in 1996 published the first paper demonstrating that nanopore sequencing may be feasible. George Church at Harvard had independently proposed a similar idea, and Church, Branton and Deamer decided to initiate a patent application which was awarded in 1998. Mark Akeson joined the research effort in 1997, and in 1999 published a paper showing that the hemolysin channel, now referred to as a nanopore, could distinguish between purine and pyrimidine bases in single RNA molecules. In 2007, Oxford Nanopore Technologies (ONT) licensed the patents describing the technology and in 2014 released the MinION nanopore sequencing device to selected researchers. The first publications appeared in 2015, one of which used the MinION to sequence E. coli DNA with 99.4% accuracy relative to the established 5.4 million base pair genome. Despite earlier skepticism, nanopore sequencing is now accepted as a viable third generation sequencing method. The original 1996 paper has been cited over 2000 times in the scientific literature, and in 2017, twenty one years later, a Google search for nanopore sequencing returned 226,000 results.
 Passage 3:Li made his professional opera debut in 2011 with the SFO as Le Dancaïre in Georges Bizet's Carmen. His subsequent appearances with the SFO include Ascanio Petrucci in Lucrezia Borgia (2011), Lorenzo in I Capuleti e i Montecchi (2012), Sciarrone in Tosca (2012), The Indian Gardener / Ben Weatherstaff in the world premiere of Nolan Gasser's The Secret Garden (2013), and both Fiorello and Don Basilio in The Barber of Seville (2013). He was also a featured soloist in a 2013 concert honoring mezzo-soprano Zheng Cao at the San Francisco War Memorial and Performing Arts Center. He has also appeared at the Seoul Arts Centre in Korea as Gremin in Eugene Onegin, and appeared in that same opera as the Captain of the Guards at the National Centre for the Performing Arts in Beijing in 2014. In 2015 he created the role of Male Soloist No. 4 in the world premiere of Huang Ruo's Paradise Interrupted at the Spoleto Festival USA.

Output: 3