niryuu/sni-each-converted huggingface dataset:
A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.
Output: adverse drug event
Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.
Output: adverse drug event
The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.
Output: adverse drug event
Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.
Output: adverse drug event
Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.
Output: adverse drug event
We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.
Output: adverse drug event
A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.
Output: adverse drug event
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.
Output: adverse drug event
Agranulocytosis and granulocytopenia associated with quetiapine.
Output: adverse drug event
A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.
Output: adverse drug event
Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.
Output: adverse drug event
Asthma and urticaria during disodium cromoglycate treatment.
Output: adverse drug event
Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.
Output: adverse drug event
CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.
Output: adverse drug event
Pilocarpine toxicity and the treatment of xerostomia.
Output: adverse drug event
Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.
Output: adverse drug event
CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.
Output: adverse drug event
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.
Output: adverse drug event
This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.
Output: adverse drug event
While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha
Output: adverse drug event
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.
Output: adverse drug event
A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.
Output: adverse drug event
In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.
Output: adverse drug event
Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.
Output: adverse drug event
Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.
Output: adverse drug event
Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.
Output: adverse drug event
METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.
Output: adverse drug event
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.
Output: adverse drug event
To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature.
Output: adverse drug event
CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.
Output: adverse drug event
CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.
Output: adverse drug event
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.
Output: adverse drug event
We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.
Output: adverse drug event
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).
Output: adverse drug event
Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.
Output: adverse drug event
The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.
Output: adverse drug event
Clofazimine induced nail changes.
Output: adverse drug event
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.
Output: adverse drug event
She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.
Output: adverse drug event
Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.
Output: adverse drug event
We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.
Output: adverse drug event
Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.
Output: adverse drug event
The 3-week sulphasalazine syndrome strikes again.
Output: adverse drug event
She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.
Output: adverse drug event
Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.
Output: adverse drug event
To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.
Output: adverse drug event
We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.
Output: adverse drug event
We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.
Output: adverse drug event
Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.
Output: adverse drug event
BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.
Output: adverse drug event
Three distinct types of minocycline-induced cutaneous pigmentation have been described.
Output: adverse drug event
Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.
Output: adverse drug event
A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.
Output: adverse drug event
When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.
Output: adverse drug event
Fatal gemcitabine-induced pulmonary toxicity in metastatic   gallbladder adenocarcinoma.
Output: adverse drug event
The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.
Output: adverse drug event
In all the patients, pellagra symptoms appeared during isoniazid therapy.
Output: adverse drug event
Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.
Output: adverse drug event
Propranolol-related bronchospasm in patients without history of asthma.
Output: adverse drug event
We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.
Output: adverse drug event
All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.
Output: adverse drug event
CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
Output: adverse drug event
BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.
Output: adverse drug event
Carbamazepine-induced systemic lupus erythematosus.
Output: adverse drug event
Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.
Output: adverse drug event
There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.
Output: adverse drug event
Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.
Output: adverse drug event
While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.
Output: adverse drug event
The most common complication of warfarin use is adverse bleeding.
Output: adverse drug event
We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.
Output: adverse drug event
Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.
Output: adverse drug event
Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.
Output: adverse drug event
A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.
Output: adverse drug event
We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.
Output: adverse drug event
Septic knee arthritis after intra-articular hyaluronate injection.
Output: adverse drug event
In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.
Output: adverse drug event
Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.
Output: adverse drug event
Stupor and fast activity on electroencephalography in a child treated with valproate.
Output: adverse drug event
Large cerebral infarction during praziquantel therapy in neurocysticercosis.
Output: adverse drug event
This was accepted as evidence for propranolol being the cause of this conduction disorder.
Output: adverse drug event
The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.
Output: adverse drug event
Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).
Output: adverse drug event
Sarcoma complicating therapy with cyclophosphamide.
Output: adverse drug event
METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.
Output: adverse drug event
Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.
Output: adverse drug event
OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.
Output: adverse drug event
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.
Output: adverse drug event
Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.
Output: adverse drug event
We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.
Output: adverse drug event
A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.
Output: adverse drug event
We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).
Output: adverse drug event
Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.
Output: adverse drug event
The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.
Output: adverse drug event
We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.
Output: adverse drug event
A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.
Output: adverse drug event
The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.
Output: adverse drug event
Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.
Output: adverse drug event
Phenytoin toxicity: an easily missed cause of cerebellar syndrome.
Output: adverse drug event
The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.
Output: adverse drug event
Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.
Output: adverse drug event
Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.
Output: adverse drug event
The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.
Output: adverse drug event
RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.
Output: adverse drug event
NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.
Output: adverse drug event
After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.
Output: adverse drug event
CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.
Output: adverse drug event
OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.
Output: adverse drug event
Exacerbation of schizophrenia associated with amantadine.
Output: adverse drug event
Aminophylline hypersensitivity apparently due to ethylenediamine.
Output: adverse drug event
A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.
Output: adverse drug event
Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.
Output: adverse drug event
In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.
Output: adverse drug event
High-grade atrioventricular block during dipyridamole stress testing.
Output: adverse drug event
We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide.
Output: adverse drug event
The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.
Output: adverse drug event
This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.
Output: adverse drug event
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.
Output: adverse drug event
We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.
Output: adverse drug event
METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.
Output: adverse drug event
Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.
Output: adverse drug event
Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.
Output: adverse drug event
A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.
Output: adverse drug event
We report here a rare case of ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant patient with myotonic dystrophy.
Output: adverse drug event
The authors describe a case of the catatonia syndrome associated with disulfiram therapy.
Output: adverse drug event
Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).
Output: adverse drug event
Does acyclovir increase serum lithium levels?
Output: adverse drug event
This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.
Output: adverse drug event
Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.
Output: adverse drug event
We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.
Output: adverse drug event
Polymyositis after propylthiouracil treatment for hyperthyroidism.
Output: adverse drug event
Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.
Output: adverse drug event
Anaphylaxis to intrathecal diamorphine.
Output: adverse drug event
Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.
Output: adverse drug event
A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.
Output: adverse drug event
The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.
Output: adverse drug event
Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.
Output: adverse drug event
INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).
Output: adverse drug event
We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.
Output: adverse drug event
We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.
Output: adverse drug event
Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.
Output: adverse drug event
Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.
Output: adverse drug event
OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).
Output: adverse drug event
Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.
Output: adverse drug event
Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.
Output: adverse drug event
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.
Output: adverse drug event
Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.
Output: adverse drug event
Captopril-associated "pseudocholangitis'.
Output: adverse drug event
a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.
Output: adverse drug event
Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.
Output: adverse drug event
BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.
Output: adverse drug event
2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.
Output: adverse drug event
Prominent positive U waves appearing with high-dose intravenous phenylephrine.
Output: adverse drug event
Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.
Output: adverse drug event
Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.
Output: adverse drug event
Acute respiratory distress syndrome after rituximab infusion.
Output: adverse drug event
There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.
Output: adverse drug event
In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.
Output: adverse drug event
Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.
Output: adverse drug event
We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.
Output: adverse drug event
Halothane hepatitis and prompt resolution with methionine therapy: case report.
Output: adverse drug event
Clofazimine enteropathy caused by crystal deposition can be life-threatening.
Output: adverse drug event
Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.
Output: adverse drug event
Severe erythroderma as a complication of continuous epoprostenol therapy.
Output: adverse drug event
STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.
Output: adverse drug event
CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.
Output: adverse drug event
An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.
Output: adverse drug event
We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).
Output: adverse drug event
We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).
Output: adverse drug event
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.
Output: adverse drug event
Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.
Output: adverse drug event
A lethal complication of peripheral vein vasopressin infusion.
Output: adverse drug event
Anaphylactoid reactions with intraperitoneal cisplatin.
Output: adverse drug event
A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.
Output: adverse drug event
PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.
Output: adverse drug event
Clozapine induced polyserositis.
Output: adverse drug event
Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.
Output: adverse drug event
Gigantomastia induced by bucillamine.
Output: adverse drug event
CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.
Output: adverse drug event
We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.
Output: adverse drug event
We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.
Output: adverse drug event
We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.
Output: adverse drug event
After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.
Output: adverse drug event
It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.
Output: adverse drug event
However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.
Output: adverse drug event
Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment.
Output: adverse drug event
Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.
Output: adverse drug event
However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.
Output: adverse drug event
This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.
Output: adverse drug event
A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).
Output: adverse drug event
Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.
Output: adverse drug event
Co-trimoxazole red cell aplasia in leukaemia.
Output: adverse drug event
OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.
Output: adverse drug event
OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
Output: adverse drug event
The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).
Output: adverse drug event
We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.
Output: adverse drug event
This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.
Output: adverse drug event
Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.
Output: adverse drug event
Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.
Output: adverse drug event
Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.
Output: adverse drug event
Paradoxical seizures in phenytoin toxicity.
Output: adverse drug event
We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.
Output: adverse drug event
Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.
Output: adverse drug event
We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.
Output: adverse drug event
We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.
Output: adverse drug event
Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.
Output: adverse drug event
Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.
Output: adverse drug event
This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.
Output: adverse drug event
This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.
Output: adverse drug event
These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.
Output: adverse drug event
The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.
Output: adverse drug event
OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.
Output: adverse drug event
We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.
Output: adverse drug event
We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.
Output: adverse drug event
Flucloxacillin-induced aplastic anaemia and liver failure.
Output: adverse drug event
Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.
Output: adverse drug event
Lansoprazole-induced thrombocytopenia.
Output: adverse drug event
RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.
Output: adverse drug event
Liver disease induced by perhexiline maleate.
Output: adverse drug event
Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.
Output: adverse drug event
Protamine allergy as a complication of insulin hypersensitivity: A case report.
Output: adverse drug event
OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.
Output: adverse drug event
PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.
Output: adverse drug event
A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.
Output: adverse drug event
We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.
Output: adverse drug event
In these patients, long-acting octreotide may trigger serious hypoglycemia.
Output: adverse drug event
Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.
Output: adverse drug event
Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.
Output: adverse drug event
PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.
Output: adverse drug event
To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.
Output: adverse drug event
Salicylate hepato toxicity in rheumatic fever.
Output: adverse drug event
A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.
Output: adverse drug event
EEG abnormalities were observed in two of the nine children during chlorambucil therapy.
Output: adverse drug event
Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.
Output: adverse drug event
We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.
Output: adverse drug event
BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.
Output: adverse drug event
Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.
Output: adverse drug event
To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.
Output: adverse drug event
Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.
Output: adverse drug event
Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.
Output: adverse drug event
Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.
Output: adverse drug event
Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.
Output: adverse drug event
Minocycline as a cause of drug-induced autoimmune hepatitis.
Output: adverse drug event
The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.
Output: adverse drug event
Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors.
Output: adverse drug event
We conclude peripheral neuropathy with 5-FU is rare.
Output: adverse drug event
After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.
Output: adverse drug event
Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.
Output: adverse drug event
This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.
Output: adverse drug event
Can propofol precipitate pancreatitis in patients with Cushing's syndrome?
Output: adverse drug event
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.
Output: adverse drug event
This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.
Output: adverse drug event
Unusual pigmentary changes associated with 5-fluorouracil therapy.
Output: adverse drug event
METHODS: Three patients with apparent itraconazole-induced liver injury were studied.
Output: adverse drug event
Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.
Output: adverse drug event
This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.
Output: adverse drug event
Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.
Output: adverse drug event
We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.
Output: adverse drug event
We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.
Output: adverse drug event
We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.
Output: adverse drug event
Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.
Output: adverse drug event
DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.
Output: adverse drug event
We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.
Output: adverse drug event
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.
Output: adverse drug event
Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.
Output: adverse drug event
A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.
Output: adverse drug event
Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.
Output: adverse drug event
A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.
Output: adverse drug event
We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.
Output: adverse drug event
In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.
Output: adverse drug event
Can ketamine prescribed for pain cause damage to the urinary tract?
Output: adverse drug event
OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.
Output: adverse drug event
CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.
Output: adverse drug event
Argatroban is hepatically cleared and may be the preferred direct thrombin inhibitor in the presence of significant renal impairment, but conversely has prolonged effects in hepatic failure.
Output: adverse drug event
Magnesium toxicosis in two horses.
Output: adverse drug event
We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.
Output: adverse drug event
Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.
Output: adverse drug event
The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.
Output: adverse drug event
In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.
Output: adverse drug event
Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.
Output: adverse drug event
This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.
Output: adverse drug event
Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.
Output: adverse drug event
According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.
Output: adverse drug event
Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.
Output: adverse drug event
Renal damage associated with long term use of lithium carbonate.
Output: adverse drug event
We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.
Output: adverse drug event
A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.
Output: adverse drug event
After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).
Output: adverse drug event
Therefore, amantadine was permanently discontinued and the cornea cleared again.
Output: adverse drug event
Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.
Output: adverse drug event
Methemoglobinemia: an occupational hazard of phenylpropanolamine production.
Output: adverse drug event
We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.
Output: adverse drug event
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.
Output: adverse drug event
Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions.
Output: adverse drug event
On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.
Output: adverse drug event
Depressive symptoms disappeared after interferon therapy was stopped.
Output: adverse drug event
Rifampicin-induced renal failure.
Output: adverse drug event
The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.
Output: adverse drug event
Cis-retinoic acid (RA) may further increase the risk of developing BMTN.
Output: adverse drug event
A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.
Output: adverse drug event