niryuu/sni-each-converted huggingface dataset:
Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites.
Output: prostaglandin
A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia.
Output: gamma-Aminolevulinate
Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans.
Output: rivastigmine
Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty.
Output: tranexamic acid
Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus.
Output: serotonin
The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation.
Output: geldanamycin
Carnitine biosynthesis. Purification of gamma-butyrobetaine hydroxylase from rat liver.
Output: gamma-butyrobetaine
Aspirin and sodium salicylate inhibit endothelin ETA receptors by an allosteric type of mechanism.
Output: sodium salicylate
Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Output: troglitazone
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
Output: potassium
Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity.
Output: [3H]paroxetine
Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2).
Output: prostaglandin endoperoxide H2
Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta.
Output: sulfasalazine
Brugada syndrome without mutation of the cardiac sodium channel gene in a Taiwanese patient.
Output: sodium
On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns.
Output: dopamine
Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD.
Output: Cl-
The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist.
Output: dopamine
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug.
Output: cystine
Advances in antihypertensive combination therapy: benefits of low-dose thiazide diuretics in conjunction with omapatrilat, a vasopeptidase inhibitor.
Output: thiazide
Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts.
Output: salicylate
Compensatory changes in enzymes of arginine metabolism during renal hypertrophy in mice.
Output: arginine
Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites.
Output: oxygen
Efficacy and safety of the factor VIII/von Willebrand factor concentrate, haemate-P/humate-P: ristocetin cofactor unit dosing in patients with von Willebrand disease.
Output: ristocetin
Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug.
Output: olopatadine
Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-alpha production.
Output: alcoholic
Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin.
Output: spermine
Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.
Output: cysteine S-conjugates
Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes.
Output: propargylamines
Pharmacodynamics and pharmacokinetics of phenylbutazone in calves.
Output: phenylbutazone
Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors.
Output: adenylyl
Effects of pentosan polysulfate sodium on the estrogen-induced pituitary prolactinoma in Fischer 344 rats.
Output: sodium
Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.
Output: ammonium
Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin.
Output: GABA
Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod.
Output: imiquimod
A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels.
Output: eicosapentaenoic acid
Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex.
Output: losartan
Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors.
Output: GTPgammaS
Tethered dimers as NAD synthetase inhibitors with antibacterial activity.
Output: NAD
A phase 1 study of tazarotene in adults with advanced cancer.
Output: tazarotene
Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.
Output: clenbuterol
Crystal structure of serine dehydratase from rat liver.
Output: serine
Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells.
Output: norepinephrine
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.
Output: 2-aryl propionic acid
Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance.
Output: GW572016
Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers.
Output: (-)-[3H]-CGP12177
Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles.
Output: norepinephrine
Decreased histamine H1 receptor binding in the brain of depressed patients.
Output: histamine
A novel membrane sensor for histamine H1-receptor antagonist "fexofenadine".
Output: histamine
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.
Output: albuterol
Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK).
Output: thiamin
Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase.
Output: pyridox(am)ine 5'-phosphate
Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts.
Output: sterol
Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients.
Output: 2'-deoxyuridine
Induction of heparin-binding EGF-like growth factor and activation of EGF receptor in imatinib mesylate-treated squamous carcinoma cells.
Output: imatinib
COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
Output: carprofen
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
Output: amrinone
Guidance on the use of miglustat for treating patients with type 1 Gaucher disease.
Output: miglustat
Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
Output: ACh
Rat hepatic stellate cells become retinoid unresponsive during activation.
Output: retinoid
Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles.
Output: amino acid
Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.
Output: monoamine
Effect of cyproheptadine on serum leptin levels.
Output: cyproheptadine
Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment.
Output: sorafenib
Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea.
Output: vasopressin
Enzymatic and biochemical properties of a novel human serine dehydratase isoform.
Output: serine
Multiple enzyme inhibitions by histamine H3 receptor antagonists as potential procognitive agents.
Output: histamine
High-mannose-type glycan modifications of dihydrofolate reductase using glycan-methotrexate conjugates.
Output: dihydrofolate
NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling.
Output: NMDA
Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide.
Output: nitric oxide
Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.
Output: argininosuccinate
Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain.
Output: glutamic acid
Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma.
Output: diacylglycerol
Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes.
Output: folic acid
D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.
Output: D-myo-inositol 1,4,5-tris phosphate
Non-enzymatic interactions of glyoxylate with lysine, arginine, and glucosamine: a study of advanced non-enzymatic glycation like compounds.
Output: glyoxylate
PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.
Output: retinoic acid
Inhibition of cardiac voltage-gated sodium channels by grape polyphenols.
Output: sodium
Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction.
Output: amrubicin
Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach.
Output: glinides
DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
Output: fatty acid
Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate.
Output: steroid
Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B.
Output: tyrosine
Increased responsiveness of rat colonic splanchnic afferents to 5-HT after inflammation and recovery.
Output: 5-HT
The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle.
Output: progesterone
Molecular recognition of histidine tRNA by histidyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1.
Output: histidine
Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
Output: serotonin
Biosynthesis of selenocysteine on its tRNA in eukaryotes.
Output: selenocysteine
Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2.
Output: glutamate
The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells.
Output: leukotriene
The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors.
Output: sorafenib
Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.
Output: 11 beta hydroxysteroid
The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population.
Output: glutathione
Methylation-mediated silencing of genes is not altered by selenium treatment of prostate cancer cells.
Output: selenium
Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial.
Output: arformoterol
Aripiprazole acts as a selective dopamine D2 receptor partial agonist.
Output: dopamine
RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism.
Output: retinol
Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo.
Output: calcium
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney.
Output: dimethylarginine
Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin.
Output: N-methyl-D-aspartate
Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.
Output: norepinephrine
Sunitinib, sorafenib and mTOR inhibitors in renal cancer.
Output: sorafenib
Management of psoriasis: the position of retinoid drugs.
Output: retinoid
Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease.
Output: monoamine
Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin.
Output: prostacyclin
DNA damage and homologous recombination signaling induced by thymidylate deprivation.
Output: thymidylate
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.
Output: nicotinamide
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Output: calcium
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.
Output: bosutinib
The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.
Output: estramustine
Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog.
Output: 3 beta-hydroxy-5-ene-steroid
Transdermal selegiline for the treatment of major depressive disorder.
Output: selegiline
Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics.
Output: glutamate
The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats.
Output: prostaglandin E2
Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role.
Output: Ca2+
Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drug.
Output: 4,5-diaryloxazole
Breast cancer and steroid metabolizing enzymes: the role of progestogens.
Output: steroid
Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel.
Output: potassium
Identification of a primary target of thalidomide teratogenicity.
Output: thalidomide
Jostling for position: optimizing linker location in the design of estrogen receptor-targeting PROTACs.
Output: estrogen
Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity.
Output: monoamine
Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine.
Output: spermine
Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase.
Output: nitric oxide
Pharmacological evidence of functional inhibitory metabotrophic glutamate receptors on mouse arousal-related cholinergic laterodorsal tegmental neurons.
Output: glutamate
New triterpenoids from the stem bark of Hypodaphnis zenkeri.
Output: triterpenoids
Two new C-15 enolic acyl phragmalin-type limonoids from Chukrasia tabularis var. velutina.
Output: limonoids
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
Output: lenalidomide
The atypical antidepressant mianserin exhibits agonist activity at kappa-opioid receptors.
Output: mianserin
Anti-inflammatory trends of 1, 3-diphenyl-2-propen-1-one derivatives.
Output: 1, 3-diphenyl-2-propen-1-one
Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: not all roads lead to Rome.
Output: cholesterol
The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study.
Output: omega-3 polyunsaturated fatty acids
Vitamin E deficiency impairs the somatostatinergic receptor-effector system and leads to phosphotyrosine phosphatase overactivation and cell death in the rat hippocampus.
Output: phosphotyrosine
CCAAT/Enhancer-binding protein-homologous protein sensitizes to SU5416 by modulating p21 and PI3K/Akt signal pathway in FRO anaplastic thyroid carcinoma cells.
Output: SU5416
Adhesion of osteoblasts to a vertically aligned TiO2 nanotube surface.
Output: TiO2
Role of oestrogen receptors on the modulation of NADPH-diaphorase-positive cell number in supraoptic and paraventricular nuclei of ovariectomised female rats.
Output: oestrogen
Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice.
Output: nitric oxide
Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction.
Output: flavones
Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs.
Output: valproic acid
Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress.
Output: amiodarone
Multifunctional targets of dietary polyphenols in disease: a case for the chemokine network and energy metabolism.
Output: polyphenols
Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells.
Output: naphtho[1,2-b]furan-4,5-dione
Effects of silver nanoparticles on the liver and hepatocytes in vitro.
Output: silver
Novel insights on the effect of nicotine in a murine colitis model.
Output: nicotine
Orexin-A suppresses postischemic glucose intolerance and neuronal damage through hypothalamic brain-derived neurotrophic factor.
Output: glucose
Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.
Output: epigallocatechin gallate
Analysis of mammalian alcohol dehydrogenase 5 (ADH5): characterisation of rat ADH5 with comparisons to the corresponding human variant.
Output: alcohol
The presence of D-fagomine in the human diet from buckwheat-based foodstuffs.
Output: D-fagomine
Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo.
Output: glycyrrhizin
Liver X Receptors and female reproduction: when cholesterol meets fertility!
Output: cholesterol
Doxorubicin decreases paraquat accumulation and toxicity in Caco-2 cells.
Output: paraquat
Aryl hydrocarbon receptor is a target of 17-Allylamino-17-demethoxygeldanamycin and enhances its anticancer activity in lung adenocarcinoma cells.
Output: 17-Allylamino-17-demethoxygeldanamycin
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Output: 4-phenyl-2-phenylaminopyridine
Hybrid carbon nanotube networks as efficient hole extraction layers for organic photovoltaics.
Output: carbon
Boron-based inhibitors of acyl protein thioesterases 1 and 2.
Output: acyl
Three-Dimensional CdS-Titanate Composite Nanomaterials for Enhanced Visible-Light-Driven Hydrogen Evolution.
Output: Hydrogen
Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling.
Output: genistein
Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design.
Output: GSK1292263
Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.
Output: flavonoid
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
Output: 8-oxoadenine
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Output: stearoyl-CoA
Development of hypoxia-inducible factor (HIF)-1α inhibitors: effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia.
Output: ortho-carborane
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
Output: anthra[1,2-d]imidazole-6,11-dione
Trichostatin A inhibits transforming growth factor-β-induced reactive oxygen species accumulation and myofibroblast differentiation via enhanced NF-E2-related factor 2-antioxidant response element signaling.
Output: oxygen
Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women.
Output: glucose
New oral anticoagulants: comparative pharmacology with vitamin K antagonists.
Output: vitamin K
Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons.
Output: estradiol
Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease.
Output: MPTP
Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Output: ethanol
Diels-Alder mediated controlled release from a poly(ethylene glycol) based hydrogel.
Output: poly(ethylene glycol)
Tricycloalternarenes F-H: three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp. using OSMAC method.
Output: terpenoids
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.
Output: quinoline
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.
Output: N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide
Cooperative effects for CYP2E1 differ between styrene and its metabolites.
Output: styrene
Nuclear receptors in bile acid metabolism.
Output: bile acid
Green tea catechin leads to global improvement among Alzheimer's disease-related phenotypes in NSE/hAPP-C105 Tg mice.
Output: catechin
25-Hydroxyvitamin D in Obese Youth Across the Spectrum of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes.
Output: Glucose
Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells.
Output: patchouli alcohol
Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties.
Output: poly(lactic acid)
Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).
Output: methyl rosmarinate
Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.
Output: resveratrol amide
Intercalation pathway in many-particle LiFePO4 electrode revealed by nanoscale state-of-charge mapping.
Output: LiFePO4
Evaluation of in vivo anti-hyperglycemic and antioxidant potentials of α-santalol and sandalwood oil.
Output: α-santalol
Investigation of astatine(III) hydrolyzed species: experiments and relativistic calculations.
Output: astatine(III)
Activation of the anti-cancer agent upamostat by the mARC enzyme system.
Output: upamostat
Population pharmacokinetics of atorvastatin and its active metabolites in children and adolescents with heterozygous familial hypercholesterolemia: selective use of informative prior distributions from adults.
Output: atorvastatin
Nocapyrones H-J, 3,6-Disubstituted α-Pyrones from the Marine Actinomycete Nocardiopsis sp. KMF-001.
Output: 3,6-Disubstituted α-Pyrones
Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats.
Output: charcoal
The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis.
Output: di(2-ethylhexyl) phthalate
Site dependent intestinal absorption of darunavir and its interaction with ketoconazole.
Output: darunavir
The accumulation of metal (Co, Cr, Cu, Mn and Zn) in freshwater Ulva (Chlorophyta) and its habitat.
Output: Mn
Exploring the Interplay Between Ligand Derivatisation and Cation Type in the Assembly of Hybrid Polyoxometalate Mn-Andersons.
Output: Polyoxometalate
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Output: flavonolignans
Comparative analysis of nutritional compositions of transgenic high iron rice with its non-transgenic counterpart.
Output: iron
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.
Output: bicyclic pyrazinone and pyrimidinone amides
The effects of the phosphodiesterase type 5 inhibitor vardenafil on cognitive performance in healthy adults: a behavioral- electroencephalography study.
Output: vardenafil
Molecular mechanism regulating 24-hour rhythm of dopamine d3 receptor expression in mouse ventral striatum.
Output: dopamine
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.
Output: (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid
The (R)-omeprazole hydroxylation index reflects CYP2C19 activity in healthy Japanese volunteers.
Output: (R)-omeprazole
Vitamin A and retinoid signaling: genomic and non-genomic effects.
Output: retinoid
Phase stability and elastic properties of chromium borides with various stoichiometries.
Output: chromium borides
Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity.
Output: estrogen
Discovery of 7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): a potent and selective transforming growth factor-β type I receptor inhibitor as a topical drug for alopecia.
Output: 7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
ARF represses androgen receptor transactivation in prostate cancer.
Output: androgen
Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-2 cells.
Output: cholesterol
Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice.
Output: imidacloprid
Cell cycle arrest, extracellular matrix changes and intrinsic apoptosis in human melanoma cells are induced by Boron Neutron Capture Therapy.
Output: Boron
Anti-adipogenic diarylheptanoids from Alnus hirsuta f. sibirica on 3T3-L1 cells.
Output: diarylheptanoids
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Output: L-cysteine
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.
Output: 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines
Effect of nicotine pretreatment on arsenic-induced oxidative stress in male Wistar rats.
Output: nicotine
Synthesis and in-silico studies of some diaryltriazole derivatives as potential cyclooxygenase inhibitors.
Output: diaryltriazole
The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes.
Output: ruthenium(ii)
Reinforcement enhancing effects of nicotine via smoking.
Output: nicotine
Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: Use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier.
Output: polyethyleneimine
Synthesis of C17-OH-north unit of ritterazine G via "Red-Ox" modifications of hecogenin acetate.
Output: ritterazine G
Efficient induction of apoptosis in HeLa cells by a novel cationic porphycene photosensitizer.
Output: porphycene
Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.
Output: pyrrolidine-2,5-dione
Protection of glycyrrhizic acid against AGEs-induced endothelial dysfunction through inhibiting RAGE/NF-κB pathway activation in human umbilical vein endothelial cells.
Output: glycyrrhizic acid
T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms.
Output: Abacavir
Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid.
Output: oxysterols
Loss of Calcium/Calmodulin-Dependent Protein Kinase II Activity in Cortical Astrocytes Decreases Glutamate Uptake and Induces Neurotoxic Release of ATP.
Output: Glutamate
Stable and high-rate overcharge protection for rechargeable lithium batteries.
Output: lithium
3-Hydroxypyridin-2-thione as Novel Zinc Binding Group for Selective Histone Deacetylase Inhibition.
Output: Zinc
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
Output: glucosylceramide
Environmental pesticide exposure modulates cytokines, arginase and ornithine decarboxylase expression in human placenta.
Output: ornithine
Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light.
Output: delphinidin glycoside
Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD).
Output: triterpenoids
2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.
Output: xanthohumol
4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors.
Output: d-Amino Acid
In vivo and in vitro anti-inflammatory potential of pentahydroxy-pregn-14-ol, 20-one-β-d-thevetopyranoside in rats.
Output: pentahydroxy-pregn-14-ol, 20-one-β-d-thevetopyranoside
The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels.
Output: ATP
The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced Stat3 phosphorylation, colony formation in soft agar and tumor growth in vivo.
Output: tyrosine
Design, Synthesis and biological evaluation of catecholamine vehicle for studying dopaminergic system.
Output: catecholamine
Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia.
Output: HPMA
Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats.
Output: bleomycin
Genetic Insights into Pyralomicin Biosynthesis in Nonomuraea spiralis IMC A-0156.
Output: Pyralomicin
Synaptotagmin 1 is required for vesicular Ca(2+) /H(+) -antiport activity.
Output: Ca(2+)
Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha.
Output: estrogen
The Intermediate-conductance Calcium-activated Potassium Channel KCa3.1 Regulates Vascular Smooth Muscle Cell Proliferation via Controlling Calcium-dependent Signaling.
Output: Potassium
Probing the Role of the Vancomycin E-Ring Aryl Chloride: Selective Divergent Synthesis and Evaluation of Alternatively Substituted E-Ring Analogues.
Output: Vancomycin
Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of Cu(I) -Loaded hCCS Domain 1 and Analysis of Disulfide-Free hSOD1 Mutants.
Output: Cu(I)
PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance.
Output: Glucose
Immunoregulatory effects of Glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4(+)CD25(+)Foxp3(+) regulatory T cells in ovalbumin-sensitized mice.
Output: Glycyrrhizic acid
Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model.
Output: vildagliptin
The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway: Uncarboxylated osteocalcin and endothelial apoptosis.
Output: phosphatidylinositol
Distinct role of PYK2 in mediating thromboxane generation downstream of both G12/13 and integrin αiibβ in platelets.
Output: thromboxane
Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats.
Output: quercetin
Drug-drug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors.
Output: HMG-CoA
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulf onyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
Output: 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulf onyl)phenyl)pyrimidine-2,4-diamine
The effect of histamine-H1 receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma.
Output: terfenadine
Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam.
Output: triazolobenzodiazepines
Intestinal permeability and lactose hydrolysis in human rotaviral gastroenteritis assessed simultaneously by non-invasive differential sugar permeation.
Output: lactose
Characteristics of the binding of phenoxybenzamine to calmodulin.
Output: phenoxybenzamine
Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.
Output: gossypol
Drug-protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin.
Output: phenoxybenzamine
Penicillin-binding proteins and role of amdinocillin in causing bacterial cell death.
Output: amdinocillin
Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides.
Output: phenothiazines
Demonstration of histamine receptors on human platelets by flow cytometry.
Output: histamine
The effect of triclosan on mediators of gingival inflammation.
Output: triclosan
The dynamics of cobalamin utilization in L-1210 mouse leukemia cells: a model of cellular cobalamin metabolism.
Output: cobalamin
Ergovaline binding and activation of D2 dopamine receptors in GH4ZR7 cells.
Output: dopamine
Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors.
Output: risperidone
Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice.
Output: desipramine
Alpha 1-adrenoceptor subtypes mediating the regulation and modulation of Ca2+ sensitization in rabbit thoracic aorta.
Output: Ca2+
Inhibitory effects of lysine analogues on t-PA induced whole blood clot lysis.
Output: lysine
Histamine enhances the depolarizing afterpotential of immunohistochemically identified vasopressin neurons in the rat supraoptic nucleus via H1-receptor activation.
Output: vasopressin
Adapalene, a new chemical entity with retinoid activity.
Output: retinoid
Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.
Output: prostaglandin D
cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration.
Output: glutamate
Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group.
Output: Tamsulosin
Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production.
Output: thalidomide
Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator.
Output: serine
Hypoxemia associated with cimetidine therapy in a newborn infant.
Output: cimetidine
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
Output: prostanoid
The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
Output: thymidine
Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride.
Output: K+
Analysis of NMDA receptors in the human spinal cord.
Output: NMDA
Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine.
Output: sodium
Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
Output: glutathione
Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain.
Output: neurotensin
Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines.
Output: amino acid
Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradation.
Output: carbetocin