niryuu/sni-each-converted huggingface dataset:
Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.
Output: norepinephrine transporter
Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states.
Output: human ether-a-go-go-related gene (HERG) potassium channel
Reduction of oral ethanol self-administration in rats by monoamine oxidase inhibitors.
Output: monoamine oxidase
A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia.
Output: erythroid-specific gamma-Aminolevulinate synthase
Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans.
Output: acetylcholinesterase
The antitussive activity of delta-opioid receptor stimulation in guinea pigs.
Output: delta-opioid receptor
Carnitine biosynthesis. Purification of gamma-butyrobetaine hydroxylase from rat liver.
Output: gamma-butyrobetaine hydroxylase
Aspirin and sodium salicylate inhibit endothelin ETA receptors by an allosteric type of mechanism.
Output: ETA receptors
A unique cytosolic activity related but distinct from NQO1 catalyses metabolic activation of mitomycin C.
Output: NQO1
Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes.
Output: plasminogen activator inhibitor-1
Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs.
Output: alpha(1)-adrenoceptor
Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice.
Output: Na+/K+/2Cl- cotransporter
Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
Output: uncoupling protein-3
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
Output: KCNQ2/Q3
Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2).
Output: human prostaglandin endoperoxide H2 synthase-2
Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta.
Output: NF-kappaB
The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells.
Output: aromatic-L-amino acid decarboxylase
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.
Output: acetylcholinesterase
Brugada syndrome without mutation of the cardiac sodium channel gene in a Taiwanese patient.
Output: cardiac sodium channel
Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma.
Output: CYP11A1
Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor.
Output: GLP-2
On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns.
Output: dopamine transporter
Evidence for genetic heterogeneity of pseudohypoaldosteronism type 1: identification of a novel mutation in the human mineralocorticoid receptor in one sporadic case and no mutations in two autosomal dominant kindreds.
Output: human mineralocorticoid receptor
Cembranoid and long-chain alkanol sites on the nicotinic acetylcholine receptor and their allosteric interaction.
Output: nicotinic acetylcholine receptor
Advances in antihypertensive combination therapy: benefits of low-dose thiazide diuretics in conjunction with omapatrilat, a vasopeptidase inhibitor.
Output: vasopeptidase
Analgesia and COX-2 inhibition.
Output: COX-2
[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
Output: HERG
Effects of the antidepressant/antipanic drug phenelzine on alanine and alanine transaminase in rat brain.
Output: alanine transaminase
Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites.
Output: COX-1
Differential binding mode of diverse cyclooxygenase inhibitors.
Output: cyclooxygenase
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
Output: histone deacetylase
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Output: AMP-activated protein kinase
Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-alpha production.
Output: TNF-alpha
Low incidence of paradoxical platelet activation by glycoprotein IIb/IIIa inhibitors.
Output: glycoprotein IIb/IIIa
Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction.
Output: NK-1 receptor
Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin.
Output: GABA type-A receptor
Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype.
Output: human alpha 2C-adrenoceptor
Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death.
Output: heat shock proteins
Investigation of bradykinin metabolism in human and rat plasma in the presence of the dual ACE/NEP inhibitors GW660511X and omapatrilat.
Output: bradykinin
A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels.
Output: cyclin D1
Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex.
Output: AT1 receptor
Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors.
Output: transforming growth factor-beta1
Inhibition by pentosan polysulfate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals.
Output: heparin-binding growth factors
Tethered dimers as NAD synthetase inhibitors with antibacterial activity.
Output: NAD synthetase
Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.
Output: beta 2-adrenoceptor
Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice.
Output: alpha 2A-adrenoceptor
Crystal structure of serine dehydratase from rat liver.
Output: serine dehydratase
Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance.
Output: Ras
Use of the norepinephrine transporter as a reporter gene for non-invasive imaging of genetically modified cells.
Output: norepinephrine transporter
Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger.
Output: beta-adrenoceptor
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.
Output: cyclooxygenase
Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance.
Output: kinase
The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function.
Output: norepinephrine transporter
Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers.
Output: human beta 1-adrenoceptors
Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles.
Output: norepinephrine transporter
Electrophysiological properties of mouse horizontal cell GABAA receptors.
Output: GABAA
Decreased histamine H1 receptor binding in the brain of depressed patients.
Output: histamine H1 receptor
Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography.
Output: histamine H1-receptor
A novel membrane sensor for histamine H1-receptor antagonist "fexofenadine".
Output: histamine H1-receptor
Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.
Output: cyclooxygenase-2
In vivo activity of the potent oxytocin antagonist on uterine activity in the rat.
Output: oxytocin
Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK).
Output: placental protein 20
Safety and tolerability of denufosol tetrasodium inhalation solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis.
Output: P2Y2 receptor
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
Output: sigma1 receptor
Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase.
Output: PNPO
Effect of 5-azacytidine and procainamide on CD3-zeta chain expression in Jurkat T cells.
Output: CD3-zeta chain
Epithelioid gastrointestinal stromal tumor with PDGFRA activating mutation and immunoreactivity.
Output: PDGFRA
Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells.
Output: interleukin-18
COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
Output: COX-2
Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.
Output: pyridoxal kinase
Losartan: a selective angiotensin II type 1 (AT1) receptor antagonist for the treatment of heart failure.
Output: angiotensin II type 1 (AT1) receptor
Effect of amrinone on tumor necrosis factor production in endotoxic shock.
Output: tumor necrosis factor
A review of the structural and functional features of olmesartan medoxomil, an angiotensin receptor blocker.
Output: angiotensin receptor
Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
Output: AChE
Protein kinase C potentiates homologous desensitization of the beta2-adrenoceptor in bovine tracheal smooth muscle.
Output: beta2-adrenoceptor
Overview of monoclonal antibodies and small molecules targeting the epidermal growth factor receptor pathway in colorectal cancer.
Output: epidermal growth factor receptor
Effect of cyproheptadine on serum leptin levels.
Output: leptin
Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE inhibitors in high dieted methionine mice.
Output: ACE
A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours.
Output: retinoid X receptor
Enzymatic and biochemical properties of a novel human serine dehydratase isoform.
Output: human serine dehydratase
High-mannose-type glycan modifications of dihydrofolate reductase using glycan-methotrexate conjugates.
Output: dihydrofolate reductase
Sorafenib: recent update on activity as a single agent and in combination with interferon-alpha2 in patients with advanced-stage renal cell carcinoma.
Output: interferon-alpha2
Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.
Output: DRD2
Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain.
Output: glutamic acid decarboxylase 65
Therapeutic targets in melanoma: map kinase pathway.
Output: map kinase
Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats.
Output: HMG-CoA reductase
D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.
Output: G protein-coupled receptor
PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.
Output: CD1d
Inhibition of cardiac voltage-gated sodium channels by grape polyphenols.
Output: voltage-gated sodium channels
Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction.
Output: topoisomerase II
The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Output: methylthioadenosine phosphorylase
Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate.
Output: steroid receptors
Characterization of the molecular mechanisms involved in the increased insulin secretion in rats with acute liver failure.
Output: insulin
Clinical, biochemical and molecular diagnosis of a compound homozygote for the 254 bp deletion-8 bp insertion of the APRT gene suffering from severe renal failure.
Output: APRT
The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle.
Output: progesterone receptor
Molecular recognition of histidine tRNA by histidyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1.
Output: histidyl-tRNA synthetase
Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
Output: serotonin transporter
Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models.
Output: S100P
Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.
Output: cyclooxygenase-2
Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2.
Output: glutamate receptor interacting protein 1
Transgenic expression of the human Vitamin D receptor (hVDR) in the duodenum of VDR-null mice attenuates the age-dependent decline in calcium absorption.
Output: human Vitamin D receptor
Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium.
Output: ENaC
Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity.
Output: lymphocyte function-associated antigen-1
A pilot study of IL-1 inhibition by anakinra in acute gout.
Output: IL-1
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Output: methionine synthase
Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.
Output: AMP-activated protein kinase
The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population.
Output: glutathione transferases M1 and T1
Characterization of 5-hydroxytryptamine1B receptors in rat spinal cord via [125I]iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release.
Output: 5-hydroxytryptamine1B
Regulation of gluconeogenesis by Kruppel-like factor 15.
Output: Kruppel-like
Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening.
Output: acetyl-coenzyme A carboxylase 2
Biology of incretins: GLP-1 and GIP.
Output: GLP-1
Aripiprazole acts as a selective dopamine D2 receptor partial agonist.
Output: dopamine D2 receptor
Cannabinoid CB1 receptors in the paraventricular nucleus and central control of penile erection: immunocytochemistry, autoradiography and behavioral studies.
Output: CB1 receptors
RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism.
Output: retinol dehydrogenase
An investigation of the absolute configuration of the potent histamine H3 receptor antagonist GT-2331 using vibrational circular dichroism.
Output: histamine H3 receptor
Characterization of the nitrosyl adduct of substrate-bound mouse cysteine dioxygenase by electron paramagnetic resonance: electronic structure of the active site and mechanistic implications.
Output: mouse cysteine dioxygenase
Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis.
Output: substance P receptor
Identification of the RLBP1 gene promoter.
Output: RLBP1
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney.
Output: dimethylarginine dimethylaminohydrolase
Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin.
Output: N-methyl-D-aspartate receptors
Sunitinib, sorafenib and mTOR inhibitors in renal cancer.
Output: mTOR
Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease.
Output: monoamine oxidase
Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin.
Output: DNA topoisomerase I
Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin.
Output: prostacyclin synthase
Current and future prospects for anticoagulant therapy: inhibitors of factor Xa and factor IIa.
Output: factor Xa
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.
Output: nicotinamide N-methyltransferase
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Output: L-type calcium channel
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.
Output: kinase
Tyrosine kinase blockers: new hope for successful cancer therapy.
Output: kinase
The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats.
Output: cyclooxygenase
Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role.
Output: alpha 1-adrenoceptor
A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation.
Output: M2 muscarinic receptor
A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons.
Output: RhoA
Captopril directly inhibits matrix metalloproteinase-2 activity in continuous ambulatory peritoneal dialysis therapy.
Output: matrix metalloproteinase-2
C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects.
Output: methylenetetrahydrofolate reductase
The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors.
Output: beta-adrenoceptor
Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity.
Output: monoamine oxidase-B
Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor.
Output: thyroid hormone receptor
Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk.
Output: cyclooxygenase-2
Effects of the histamine H1 antagonist chlorcyclizine on rat fetal palate development.
Output: histamine H1
Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine.
Output: spermine synthase
Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug.
Output: RANKL
Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase.
Output: cyclooxygenase-2
Pharmacological evidence of functional inhibitory metabotrophic glutamate receptors on mouse arousal-related cholinergic laterodorsal tegmental neurons.
Output: metabotrophic glutamate receptors
A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress.
Output: Chk1
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.
Output: mTOR
Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration.
Output: K-ras
Berberine inhibits myofibroblast differentiation in nasal polyp-derived fibroblasts via the p38 pathway.
Output: p38
The atypical antidepressant mianserin exhibits agonist activity at kappa-opioid receptors.
Output: kappa-opioid
Correlation of high urinary Smad1 level with glomerular hyperfiltration in type 2 diabetes mellitus.
Output: Smad1
Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.
Output: TCF7L2
Vitamin E deficiency impairs the somatostatinergic receptor-effector system and leads to phosphotyrosine phosphatase overactivation and cell death in the rat hippocampus.
Output: phosphotyrosine phosphatase
CCAAT/Enhancer-binding protein-homologous protein sensitizes to SU5416 by modulating p21 and PI3K/Akt signal pathway in FRO anaplastic thyroid carcinoma cells.
Output: p21
Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease.
Output: opioid receptor
Role of oestrogen receptors on the modulation of NADPH-diaphorase-positive cell number in supraoptic and paraventricular nuclei of ovariectomised female rats.
Output: oestrogen receptors
Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2α/CHOP-dependent manner.
Output: DR5
Microtubule network is required for insulin-induced signal transduction and actin remodeling.
Output: actin
Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.
Output: spermidine/spermine-N(1)-acetyltransferase
In vitro metabolism of the 5-hydroxytryptamine1B receptor antagonist elzasonan.
Output: 5-hydroxytryptamine1B
Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress.
Output: caspase
Amino acid residues at the N- and C-termini are essential for the folding of active human butyrylcholinesterase polypeptide.
Output: human butyrylcholinesterase
Multifunctional targets of dietary polyphenols in disease: a case for the chemokine network and energy metabolism.
Output: chemokine
Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.
Output: EP3
The catalytic competence of cytochrome P450 in the synthesis of serotonin from 5-methoxytryptamine in the brain: an in vitro study.
Output: cytochrome P450
Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells.
Output: JNK
Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo.
Output: high-mobility group box-1
Design, synthesis and structure-activity relationship of new arginine vasopressin analogues containing proline derivatives in position 2.
Output: arginine vasopressin
β-catenin regulates GnRH-induced FSHβ gene expression.
Output: FSHβ
The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia.
Output: SYK
The fidelity of transcription: RPB1 (RPO21) mutations that increase transcriptional slippage in S. cerevisiae.
Output: RPB1
Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures.
Output: connexin43
Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.
Output: cytidine deaminase
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Output: TNIK
Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling.
Output: RhoA
Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design.
Output: GPR119
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
Output: Toll-like receptor 7
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Output: stearoyl-CoA desaturase
Effects of Yerba Mate tea (Ilex paraguariensis) on vascular endothelial function and liver lipoprotein receptor gene expression in hyperlipidemic rats.
Output: lipoprotein receptor
Coming full circle: contributions of central and peripheral oxytocin actions to energy balance.
Output: oxytocin
Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein.
Output: ΔNp63
Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells.
Output: GLUT4
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
Output: telomerase
Cannabinoid discrimination and antagonism by CB(1) neutral and inverse agonist antagonists.
Output: CB(1)
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.
Output: phosphodiesterase 5
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.
Output: Mcl-1
Cooperative effects for CYP2E1 differ between styrene and its metabolites.
Output: CYP2E1
RANKL targeted peptides inhibit osteoclastogenesis and attenuate adjuvant induced arthritis by inhibiting NF-κB activation and down regulating inflammatory cytokines.
Output: NF-κB
Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).
Output: matrix metalloproteinase-1
The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes: control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway.
Output: p53
Novel locus including FGF21 is associated with dietary macronutrient intake.
Output: FGF21
Activation of the anti-cancer agent upamostat by the mARC enzyme system.
Output: mARC
Differential autophagic cell death under stress with ectopic cytoplasmic and mitochondrial-specific PPP2R2B in human neuroblastoma cells.
Output: PPP2R2B
Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats.
Output: factor Xa
Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-Carbonic Anhydrase from Trypanosoma cruzi, the Causative Agent of Chagas Disease.
Output: α-Carbonic Anhydrase
Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway.
Output: AMPK
The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology.
Output: VEGF-D
Switchable Elastin-Like Polypeptides that Respond to Chemical Inducers of Dimerization.
Output: Elastin-Like Polypeptides
The CRF(1) receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: Comparison with paroxetine and D-cycloserine.
Output: CRF(1) receptor
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.
Output: CC-chemokine receptor 4
Differential gene expression in ERα-positive and ERα-negative breast cancer cells upon leptin stimulation.
Output: leptin
Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism.
Output: Foxa2
Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.
Output: STAT3
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures.
Output: supercoiling domains
The effects of the phosphodiesterase type 5 inhibitor vardenafil on cognitive performance in healthy adults: a behavioral- electroencephalography study.
Output: phosphodiesterase type 5
Molecular mechanism regulating 24-hour rhythm of dopamine d3 receptor expression in mouse ventral striatum.
Output: dopamine d3 receptor
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.
Output: (AMPA) receptor
Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition.
Output: Human Cytochromes P450 2A13, 2A6, and 1B1
Discovery of a Novel Selective PPARγ Ligand with Partial Agonist Binding Properties by Integrated in Silico/in Vitro Work Flow.
Output: PPARγ
The (R)-omeprazole hydroxylation index reflects CYP2C19 activity in healthy Japanese volunteers.
Output: CYP2C19
Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity.
Output: estrogen receptor
Discovery of 7-methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): a potent and selective transforming growth factor-β type I receptor inhibitor as a topical drug for alopecia.
Output: transforming growth factor-β type I receptor
ARF represses androgen receptor transactivation in prostate cancer.
Output: androgen receptor
Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.
Output: STAT3
Benzenesulfonamides: a unique class of chemokine receptor type 4 inhibitors.
Output: chemokine receptor type 4
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.
Output: Bcl-2
Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: II. Computational Modeling.
Output: Aromatase
Synthesis and in-silico studies of some diaryltriazole derivatives as potential cyclooxygenase inhibitors.
Output: cyclooxygenase
Multilevel regulation of 2-cys peroxiredoxin reaction cycle by s-nitrosylation.
Output: 2-cys peroxiredoxin
Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: Use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier.
Output: SHP-1
Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle.
Output: Cdk1
Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe.
Output: Niemann-Pick C1
Design, Synthesis, Biological Evaluation, and Docking Studies of (S)-Phenylalanine Derivatives with a 2-Cyanopyrrolidine Moiety as Potent Dipeptidyl Peptidase 4 Inhibitors.
Output: Dipeptidyl Peptidase 4
Bioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice.
Output: mdr1a
Aberrant activation of M phase proteins by cell proliferation-evoking carcinogens after 28-day administration in rats.
Output: M phase proteins
Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.
Output: ERK
Loss of Calcium/Calmodulin-Dependent Protein Kinase II Activity in Cortical Astrocytes Decreases Glutamate Uptake and Induces Neurotoxic Release of ATP.
Output: Calcium/Calmodulin-Dependent Protein Kinase II
3-Hydroxypyridin-2-thione as Novel Zinc Binding Group for Selective Histone Deacetylase Inhibition.
Output: Histone Deacetylase
An analysis of skeletal development in osteoblast- and chondrocyte-specific Runx2 knockout mice.
Output: Runx2
A Mineral Extract from red Algae Ameliorates Chronic Spontaneous Colitis in IL-10 Deficient Mice in a Mouse Strain Dependent Manner.
Output: IL-10
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
Output: glucosylceramide synthase
Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light.
Output: photoreceptor
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate.
Output: ASIC
4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors.
Output: d-Amino Acid Oxidase
Comparative study on transcriptional activity of 17 parabens mediated by estrogen receptor α and β and androgen receptor.
Output: estrogen receptor α and β
Hypermethylation of P15, P16, and E-cadherin genes in ovarian cancer.
Output: E-cadherin
Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors.
Output: acetylcholinesterase
Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors.
Output: oxidosqualene cyclase
The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels.
Output: pannexin
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I).
Output: histamine H3 receptor
Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD.
Output: mono-, bi-, and tri-dentate anion receptors
Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia.
Output: heat shock protein
Effects of High Iron and Glucose Concentrations over the Relative Expression of Bcl2, Bax, and Mfn2 in MIN6 Cells.
Output: Mfn2
Adenovirus-delivered angiopoietin-1 treatment for phosgene-induced acute lung injury.
Output: angiopoietin-1
Design, Synthesis and Biological Evaluation of Aminoalkylindole Derivatives as Cannabinoid Receptor Ligands with Potential for Treatment of Alcohol Abuse.
Output: Cannabinoid Receptor
Immunoregulatory effects of Glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4(+)CD25(+)Foxp3(+) regulatory T cells in ovalbumin-sensitized mice.
Output: cytokines
Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model.
Output: dipeptidyl peptidase-4
Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis).
Output: insulin
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulf onyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
Output: anaplastic lymphoma kinase
The effect of histamine-H1 receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma.
Output: histamine-H1 receptor
Inhibition of 5-lipoxygenase pathway of arachidonic acid metabolism in human neutrophils by sulfasalazine and 5-aminosalicylic acid.
Output: 5-lipoxygenase
Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions.
Output: beta-1 adrenoceptor
Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites.
Output: histamine H1 receptor
Multiple affinity states of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Opiate agonist association rate is a function of receptor occupancy.
Output: opiate receptor
Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.
Output: LDH-X
Demonstration of histamine receptors on human platelets by flow cytometry.
Output: histamine receptors
The effect of vitamin B6 deficiency on alanine: glyoxylate aminotransferase isoenzymes in rat liver.
Output: alanine: glyoxylate aminotransferase
Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype.
Output: alpha 1B-adrenoceptor
Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice.
Output: beta 1-adrenoceptors
Inhibitory effects of lysine analogues on t-PA induced whole blood clot lysis.
Output: t-PA
Histamine enhances the depolarizing afterpotential of immunohistochemically identified vasopressin neurons in the rat supraoptic nucleus via H1-receptor activation.
Output: H1-receptor
Comparative effects of three different potent renin inhibitors in primates.
Output: renin
Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.
Output: prostaglandin D synthase
Tamsulosin, the first prostate-selective alpha 1A-adrenoceptor antagonist. A meta-analysis of two randomized, placebo-controlled, multicentre studies in patients with benign prostatic obstruction (symptomatic BPH). European Tamsulosin Study Group.
Output: alpha 1A-adrenoceptor
Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users.
Output: vesicular monoamine transporter
Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator.
Output: hyaluronan-binding protein
Activation of cytoprotective prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effect.
Output: prostaglandin synthase-1
Clinical manifestations of genetic defects affecting gonadotrophins and their receptors.
Output: gonadotrophins
Cloning, characterization, and expression of a calcitonin receptor from guinea pig brain.
Output: calcitonin receptor
Adenosine deaminase is a specific partner for the Grb2 isoform Grb3-3.
Output: Grb2
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
Output: mouse prostanoid receptors
The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
Output: thymidine kinase
Analysis of NMDA receptors in the human spinal cord.
Output: NMDA receptors
Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine.
Output: sodium channel
Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
Output: human alpha class glutathione transferases
Isoform-specific inhibition of L-type calcium channels by dihydropyridines is independent of isoform-specific gating properties.
Output: L-type calcium channels
Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines.
Output: Cat1
Effect of lintitript, a new CCK-A receptor antagonist, on gastric emptying of a solid-liquid meal in humans.
Output: CCK-A receptor
Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide.
Output: sulfonylurea receptor