niryuu/sni-each-converted huggingface dataset:
The myb proto oncogene product ( c - Myb ) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis .
Output: c - Myb
From this comparison of aa sequences , the ATPK7 protein is considered to be a member of a novel subfamily of Ser / Thr PKs in plants .
Output: ATPK7 protein
Thus , BCR ligation initiates a PI 3 - kinase / Akt / GSK - 3 signaling pathway .
Output: GSK - 3
The vaccine was highly immunogenic , since 111 of 113 patients ( 98 % ) produced anti - HBs ( 10 mIU / ml or more ) .
Output: anti - HBs
The results of the transient - transfection assay showed that the Sp1 binding element located in the core region ( positions - - 64 to + 1 ) of the alpha2 - integrin promoter plays an essential role in the alpha2 - integrin promoter activity and its downregulation by Erb - B2 .
Output: Sp1 binding element
IL - 6 was detected in the urine of 52 % of children with pyelonephritis compared with 15 % of other children ( P < 0 . 001 ) .
Output: IL - 6
CONCLUSIONS : These results suggest that histamine - 2 receptor activation mechanisms may not be involved in postoperative IL - 6 synthesis .
Output: IL - 6
Previous studies have shown that the IME1 gene is required for sporulation and the expression of meiosis specific genes in Saccharomyces cerevisiae .
Output: IME1 gene
Recently , we and other laboratories have identified a family of caveolin - related proteins ; caveolin has been re - termed caveolin - 1 .
Output: caveolin - 1
DRAP27 is recognized by CD9 antibodies .
Output: CD9 antibodies
A rare tRNA - Arg ( CCU ) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae .
Output: Ty1 element
p185c - neu + , EGFr + ( M1 ) , and p185c - neu - kinase inactive , EGFr + ( NEN757 ) expressing cells undergo different mitotic responses to EGF .
Output: EGFr +
An scrR promoter fragment , which dose not contain a sequence resembling OB , was not shifted by the fusion protein .
Output: scrR promoter fragment
Each receptor must therefore engage a unique subset of the available signaling elements - - at least partly through the selection of proteins with src - homology 2 domains ( SH2 proteins ) .
Output: SH2 proteins
The RTI40 gene spans 35 kilobase pairs ; it contains 6 exons and at least 6 rat Identifier repetitive elements .
Output: RTI40 gene
Whereas the sequence of alpha - actinin ( Noegel , A . , W .
Output: alpha - actinin
The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos .
Output: maternal par genes
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells : a comparison of the " hot spot " mutant phenotypes .
Output: p53 DNA
Excess recombinant PTB squelches the splicing switch and reestablishes exon skipping as the predominant splicing pathway .
Output: recombinant PTB
The program for myogenic differentiation is subject to negative control by several peptide growth factors and by the products of mutationally activated ras oncogenes , which persistently activate intracellular cascades normally triggered by specific growth factors .
Output: ras oncogenes
The BHV - 1 UL24 , UL25 , UL26 and UL26 . 5 transcripts all terminated at a common 3 ' - polyadenylation site and varied significantly in their relative abundance .
Output: UL26 . 5
We discuss the possibility that DNA - protein interactions at homologous nucleotide sequences like those identified in PII are part of a regulatory gene cascade that participates in timing fla gene expression in the C . crescentus cell cycle .
Output: fla gene
SF1 / mBBP utilizes a " maxi - K homology " ( maxi - KH ) domain for recognition of the single - stranded BPS and requires a cooperative interaction with splicing factor U2AF65 bound to an adjacent polypyrimidine tract ( PPT ) for high - affinity binding .
Output: maxi - KH
In cells co - expressing high levels of the p38 ( MAPK ) kinase ( MKK3 ) together with the p38 ( MAPK ) , a significant inhibition of mitogen - induced cyclin D1 expression was observed .
Output: cyclin D1
Sequence analysis identifies a ras - associating ( RA ) - like domain in the N - termini of band 4 . 1 / JEF domains and in the Grb7 / 10 / 14 adapter family .
Output: ras - associating
Complementary DNA libraries from liver and ovary of an immature female channel catfish were screened with a homologous ERalpha cDNA probe .
Output: homologous ERalpha cDNA
FdsR purified to homogeneity after overexpression of fdsR in E . coli is a 130 kDa homotetramer binding to the fds control region located between the fdsR and fdsG genes .
Output: fdsG genes
LT - beta transcription is maximal in the thymic medulla and in splenic white pulp .
Output: LT - beta
The LT - beta gene is expressed in lymphoid cells and organs , but little is known about its inducible regulation .
Output: LT - beta
Neither symptoms , virions , nor viral RNA was detectable in plants inoculated with this mutant or a mutant with a frameshift mutation in the coat gene .
Output: coat gene
The human CA11 gene appears to be located between the secretor type alpha ( 1 , 2 ) - fucosyltransferase gene cluster ( FUT1 - FUT2 - FUT2P ) and the D - site binding protein gene ( DBP ) on chromosome 19q13 . 3 .
Output: human CA11 gene
Binding of C / EBPs to all three spi 2 . 3 3 ' UTR repressor sites , although rather weak , was confirmed by electrophoretic mobility shift assays that otherwise failed to reveal specific interactions with other liver nuclear proteins in vitro .
Output: C / EBPs
Transfection of both Calu - 6 and JEG - 3 cells with a PKA expression vector resulted in a 10 - fold induction of human renin transcriptional activity in constructs containing the native or consensus CRE and 5 - fold activation in a construct containing a nonfunctional CRE .
Output: human renin
Following immunization of transgenic mice , hybrid molecules were isolated from B cell DNA which contained the transgene recombined with the endogenous IgH locus .
Output: endogenous IgH locus
Indeed , DEX also enhanced the RA - dependent increase in RARbeta mRNA in a cycloheximide - sensitive manner .
Output: RARbeta mRNA
We have determined the complete cDNA sequence of rat plectin from a number of well - characterized overlapping lambda gt11 clones .
Output: rat plectin
At promoters that initiate with + 1 GGG , T7 RNAP synthesizes a ladder of poly ( G ) products as a result of slippage of the transcript on the three C residues in the template strand from + 1 to + 3 .
Output: T7 RNAP
Thus , in V . furnissii , the E . coli manX equivalent comprises two genes , which are separated in the genome by two other genes of the ptsM complex .
Output: ptsM complex
We report the complete nucleotide sequence of the camC gene along with 155 base pairs of 5 ' and 175 base pairs of 3 ' flanking sequence .
Output: camC gene
The POU - specific domain of Pit - 1 is essential for sequence - specific , high affinity DNA binding and DNA - dependent Pit - 1 - Pit - 1 interactions .
Output: Pit - 1
Our data indicate that the various subunits of the human P - TEFb complex may play distinct roles at multiple stages to mediate Tat activation of HIV - 1 transcription elongation .
Output: P - TEFb
In this study we cloned the cDNA of AD1 Ag from a rat basophilic leukemia 2H3 cDNA library .
Output: AD1 Ag
A GT - rich sequence binding the transcription factor Sp1 is crucial for high expression of the human type VII collagen gene ( COL7A1 ) in fibroblasts and keratinocytes .
Output: transcription factor Sp1
Here we show that inhibition occurs with a NS1 - Rev chimera in which the 78 amino - terminal amino acids of the NS1A protein comprising its entire RNA - binding domain is deleted , thereby establishing that this carboxyl portion of the NS1A protein can function as an independent effector domain .
Output: NS1A protein
We also identified a DNA fragment , 10 . 7 kbp upstream from the first coding exon of human aFGF , whose sequence is conserved in both the primate and rodent genomes .
Output: human aFGF
Based on PCR strategies and expression studies , we define the genomic organization of the FUT8b gene .
Output: FUT8b gene
Tubular dysfunction in renal lithiasis : cause or consequence ? ] To investigate whether overall tubular dysfunction is encountered in a particular subgroup of patients with urolithiasis , the following parameters of renal tubular function have been measured in fasting morning urine in 124 male stone formers : excretion of lysozyme and gamma - glutamyl transpeptidase ( gamma - GT ) , fractional excretion ( FE ) or glucose , insulin , bicarbonate after an alkali load , and theoretical phosphate threshold ( TmP / GFR ) .
Output: gamma - GT
They are transduced through TM to the cytoplasmic portion ( cytoloops and the C - terminal tail ) of the receptor and then , transferred to cytoplasmic signaling molecules , such as G protein .
Output: G protein
To further identify the residues responsible for the activity , we isolated the mutant viruses that were not neutralized with the soluble form of MHV receptor proteins , since such mutants were expected to have mutations in amino acids responsible for receptor - binding activity .
Output: MHV receptor proteins
To increase the number of circulating polymorphonuclear neutrophils , the patient was treated with recombinant granulocyte - macrophage colony - stimulating factor ( GM - CSF ) at a dose of 2 micrograms protein / kg bodyweight s . c . / 12 h .
Output: GM - CSF
Therefore , we have reevaluated the age - related changes in serum leptin levels and their relationship with adiposity and androgen levels in a large group of community dwelling men .
Output: serum leptin
The phosphoprotein pUL69 of human cytomegalovirus ( HCMV ) , which is a herpesvirus of considerable medical importance in immunosuppressed patients and newborns , has previously been identified as an early - late viral protein that can stimulate several viral and cellular promoters and thus exerts a rather broad activation pattern .
Output: phosphoprotein pUL69
In contrast , T229E - p70s6k migrated more slowly in SDS - polyacrylamide gels , but demonstrated partial kinase activity ( approximately 20 % compared with the wild type ) .
Output: T229E - p70s6k
As a test of this hypothesis , we predicted that mice which have altered expression of class I gene products , the beta2 - microglobulin knockout mice , [ beta2m ( - / - ) ] , would develop Fe overload .
Output: beta2 - microglobulin
Human CD38 , a leukocyte receptor and ectoenzyme , is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide + - converting enzymes : extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP - ribosyl cyclase .
Output: Human CD38
The leader peptide was hypothesized to inhibit ribosome release at the tnaC stop codon , thereby blocking Rho ' s access to the transcript .
Output: tnaC stop codon
These studies reveal that CREM , a tissue - specific factor , is expressed and regulated by gonadotropins in the ovary , that the predominant CREM transcripts encode the repressor protein ICER , and that ICER is capable of inhibiting cAMP - induced expression of the inhibin alpha - subunit gene .
Output: repressor protein ICER
Next , to examine the regulation mechanism of CD44 / ERM interaction in vivo , we reexamined the immunoprecipitated CD44 / ERM complex from BHK cells and found that it contains Rho - GDP dissociation inhibitor ( GDI ) , a regulator of Rho GTPase .
Output: Rho GTPase
Vav and Dbl are members of a novel class of oncogene proteins that share significant sequence identity in a approximately 250 - amino - acid domain , designated the Dbl homology domain .
Output: Dbl homology domain
DNA elements recognizing NF - Y and Sp1 regulate the human multidrug - resistance gene promoter .
Output: NF - Y
Furthermore , addition of the recombinant NF - YA subunit restores NF - Y binding .
Output: NF - Y
Here we show that one nudF suppressor also suppresses hs - mutations in nudA , nudC , and nudG and deletions in nudA and nudF .
Output: nudF suppressor
After 5 days stimulation with G - CSF ( 10 micrograms / kg ) 1l of blood was drawn , kept unprocessed for 3 days and reinfused 24 h after completion of chemotherapy .
Output: G - CSF
G - CSF ( 10 microg / kg ) was started on day + 1 and all patients engrafted within a median day number of 12 ( range , 10 - 22 ) until leukocytes > 1 . 0 x 10 ( 9 ) / l and a median day number of 56 ( range , 10 - 180 ) until platelets > 20 . 0 x 10 ( 9 ) / l ( ie platelet transfusion independence ) .
Output: G - CSF
We compared retrospectively the efficacy of granulocyte colony stimulating factor ( G - CSF ) alone with chemotherapy plus G - CSF in mobilizing CD34 - positive cells in patients with malignant lymphoma .
Output: G - CSF
We screened an A . thaliana cDNA library , whose inserts are under the control of the galactose - inducible GAL10 promoter , for cDNAs which enabled YDH8 cells to grow at the restrictive temperature .
Output: GAL10 promoter
Subclones of R15 which reverted to kappa light chain production contained genomic deletions of R15ns and / or the surrounding intron .
Output: kappa light chain
Whether or not these novel repeated sequences throughout the SMA region are involved in the disease remains to be determined .
Output: SMA region
By a combination of alternative promoter usage and exon splicing , each ROR gene generates several isoforms that differ only in their amino terminus .
Output: ROR gene
We report the cloning of the ade1 gene on a 4 . 4 kb Sau3A insert in the yeast shuttle vector pWH5 .
Output: ade1 gene
Furthermore , the rapid light - mediated increase of CPRF proteins was insensitive to transcriptional inhibitors , suggesting that a post - transcriptional mechanism controls CPRF accumulation .
Output: CPRF proteins
The pepI gene was overexpressed in Escherichia coli .
Output: pepI gene
The deduced amino - acid sequence of the mature enzyme showed very low homology ( < 20 . 4 % identity ) to those of known pectinolytic enzymes in the large pectate lyase superfamily ( the polysaccharide lyase family 1 ) .
Output: pectate lyase superfamily
Presently , we made chain pair switch , chimeric , and site mutant gamma delta TCRs and transfected them into TCR - mutant Jurkat T cells to examine the effects of changing the TCR gamma junctional region sequences on reactivity to prenyl pyrophosphate Ags .
Output: prenyl pyrophosphate Ags
Effectively , the upstream , housekeeping - type promoter responds to FIXK and positively regulates the downstream , sigma 54 - type promoter .
Output: sigma 54
Muscle and liver biopsies demonstrated the same anomalies , again without branching enzyme deficiency in the liver .
Output: branching enzyme
As a member of the uncoupling protein family , UCP2 is ubiquitously expressed in rodents and humans , implicating a major role in thermogenesis .
Output: uncoupling protein family
The herpesvirus entry mediator C ( HveC ) , previously known as poliovirus receptor - related protein 1 ( PRR1 ) , and the herpesvirus Ig - like receptor ( HIgR ) are the bona fide receptors employed by herpes simplex virus - 1 and - 2 ( HSV - 1 and - 2 ) for entry into the human cell lines most frequently used in HSV studies .
Output: poliovirus receptor
Upstream of the afa - 3 gene cluster , a 1 . 2 - kb region was found to be 96 % identical to the RepFIB sequence of one of the enterotoxigenic E . coli plasmids ( P307 ) , suggesting a common ancestor plasmid .
Output: RepFIB sequence
Insulin therapy has been expanded by development of human insulin and new modes of injection , including insulin pumps .
Output: human insulin
A V1 mutant generated in vivo with 11 of the 14 N - terminal amino acids altered , was viable and produced symptoms typical of a wild - type infection .
Output: V1 mutant
We propose that U73 is involved in methylation of the G1739 residue of the human 28S rRNA .
Output: human 28S rRNA
Here we show that these sequences are essential for processing of U18 and snR38 snoRNAs and that they compensate for the lack of a canonical terminal stem .
Output: snR38 snoRNAs
We have isolated two H19 cDNAs ( AP and ES ) that contain this ORF4 and correspond to incomplete copies of the unique 2 . 3 kb H19 RNA .
Output: H19 cDNAs
Nine months after the end of the vaccination anti - HBsAg levels had dropped to 9 + / - 4 IU / 1 ( M + / - SE ) , with a geometric mean of 5 IU / 1 , in the nine remaining evaluable patients .
Output: anti - HBsAg
Here , we characterize TCR / CD48 and TCR / CD28 costimulation in T cells expressing Lck Src homology 3 ( SH3 ) mutants .
Output: Src homology 3
The NF - kappa B precursor p100 ( lyt - 10 , p97 , p98 ) generates after proteolytic processing a 52 kDa subunit , which can bind to kappa B - motifs .
Output: lyt - 10
Blockade of T cell activation using a surface - linked single - chain antibody to CTLA - 4 ( CD152 ) .
Output: CTLA - 4
Overexpression of SNURF in cultured mammalian cells enhanced not only androgen , glucocorticoid , and progesterone receptor - dependent transactivation but also basal transcription from steroid - regulated promoters .
Output: progesterone receptor
These two enhancer elements also enhanced transcription when fused separately to the basal promoter region of the chicken vimentin gene .
Output: chicken vimentin gene
The results suggest that both superficial and deep cortical venous drainage of the cat kidney should be considered when measuring renal renin release .
Output: renal renin
Maximum overexpression of holoenzyme activity was achieved by the inclusion in such plasmids of Salmonella typhimurium cysG , which encodes a uroporphyrinogen III methyltransferase required for the synthesis of siroheme , a cofactor for the hemoprotein .
Output: uroporphyrinogen III methyltransferase
Thus , the potential induction of this gene rearrangement by E1A gene therapy is unlikely to be clinically significant in the treatment of advanced malignant disease .
Output: E1A gene
NSD1 contains a SET domain and multiple PHD fingers .
Output: SET domain
A cDNA for human microfibril - associated glycoprotein - 2 ( MAGP - 2 ) was used to screen a human leukocyte genomic DNA library in EMBL - 3 vector .
Output: MAGP - 2
Recombinant Human Erythropoietin and Platinum - Based Chemotherapy In Advanced Ovarian Cancer
Output: Recombinant Human Erythropoietin
The UL3 ORF of 204 amino acids shows significant homology to UL3 ( nuclear phosphoprotein ) of HSV - 1 ( 62 % ) and PRV ( 53 % ) .
Output: UL3 ORF
In human myxoid liposarcoma , a chromosomal rearrangement leads to fusion of the growth - arresting and DNA - damage - inducible transcription factor CHOP ( GADD153 ) to a peptide fragment encoded by the TLS gene .
Output: TLS gene
Engineering temperature - sensitive SH3 domains .
Output: SH3 domains
SH3A competes with the SH3 domains of Grb2 in binding to mSos1 , and the intersectin - mSos1 complex can be separated from Grb2 by sucrose gradient centrifugation .
Output: SH3 domains
The mRNA for this protein is expressed in the T - ALL cell line Jurkat and has been designated HUG1 , for HOX11 Upstream Gene .
Output: HOX11 Upstream Gene
Blood samples for determination of fibrinolytic activity and factor VIII in plasma were obtained before and immediately after the end of compression and application of a stocking , respectively .
Output: factor VIII
A simple procedure for accurate quantitation of factor VIII inhibitors .
Output: factor VIII
The sections were stained with anti - polymorphonuclear leukocyte antibody , the endothelial marker factor VIII - related antigen , and with hematoxylin and eosin .
Output: factor VIII
The authors recommend in cases with an elevated transaminase serum activity more frequent check - up examinations to avoid missing of a relapse , and to examine repeatedly IgM anti - HAV as in protracted forms of hepatitis IgM anti - HAV may persist even when the transaminase activity is normal .
Output: anti - HAV
The aromatic hydrocarbon receptor ( AHR ) is a ligand - activated transcription factor that regulates the expression of several drug - metabolizing enzymes and has been implicated in immunosuppression , teratogenesis , cell - specific hyperplasia , and certain types of malignancies and toxicities .
Output: aromatic hydrocarbon receptor
Therefore , a structural interaction between PsaL and PsaI may stabilize the association of PsaL with the photosystem I core .
Output: photosystem I core
Elements regulating cell - and stage - specific expression of the C . elegans MyoD family homolog hlh - 1 .
Output: hlh - 1
CONCLUSIONS - - Postlumbar puncture headache may be mediated by the release of substance P triggered by lumbar puncture , in patients predisposed to headache by a hypersensitivity to substance P .
Output: substance P
The treatment with glucocorticoids and immunosuppressants resulted in a more noticeable decrease in the levels of T3 and E - RCF .
Output: E - RCF
Characterization of a unique protein component of yeast RNase MRP : an RNA - binding protein with a zinc - cluster domain .
Output: yeast RNase MRP
To clone cDNAs for the beta subunit of rabbit eIF - 2B , amino acid sequence data was first obtained and used to design redundant oligonucleotide primers for use in PCR .
Output: eIF - 2B
The human parvalbumin mRNA contains the putative polyadenylation signal AATAAA 13 nucleotides upstream from the polyadenylation site .
Output: human parvalbumin mRNA
No promoter activity could be detected with various mouse Fli - 1 promoter - CAT constructs containing 600 bp of the 5 ' flanking region , the complete exon 1 , the 5 ' end of intron 1 and / or retroviral LTR sequence .
Output: Fli - 1
Analysis of the DNA - binding and transcriptional activation functions of human Fli - 1 protein .
Output: Fli - 1
Fli - 1 is a proto - oncogene which is rearranged in tumors induced by three different retroviruses , Cas - Br - E , F - MuLV , and 10A1 .
Output: Fli - 1
We identify YY1 recognition sequences within the vitamin D response element ( VDRE ) of the osteocalcin gene that are critical for YY1 - dependent repression of vitamin D - enhanced promoter activity .
Output: osteocalcin gene
Identification of an osteocalcin gene promoter sequence that binds AP1 .
Output: osteocalcin gene
Unestablished quail myoblasts were infected with a retroviral vector encoding the oncogenic form of H - Ras in order to investigate the mechanism by which this oncoprotein interferes with terminal differentiation .
Output: H - Ras
Our results show that unlike the case for sos1 , sos2 gene function is dispensable for normal mouse development , growth , and fertility .
Output: sos2 gene
Creatinine and creatine phosphokinase ( CPK ) .
Output: creatine phosphokinase
Central ( heart rate , VE , VO2 ) or local ( muscle and blood lactate , adenosine triphosphate , creatine phosphokinase , glycogen ) cues highlighted in these studies demonstrate both the complexity of effort perception , and the need for better understanding of the physiological components upon which it is based .
Output: creatine phosphokinase
INTERVENTIONS : Postoperative follow - up consisted of serial determination of different biochemical markers ( CK , CK - MB , cTnI ) , ECGs , and echocardiography .
Output: CK - MB
Our case , however , had no histologic evidence of malignancy , no serum alpha fetoprotein at 7 months of age , and no recurrence at 1 years .
Output: serum alpha fetoprotein
Although hSSTR5 displays approximately 75 % sequence identity with rat SSTR5 , the two receptors display significantly different pharmacological profiles , especially with respect to their binding affinities for the SST analogue SMS 201 - 995 .
Output: rat SSTR5
Phytohemagglutinin ( PHA ) , the seed lectin of the common bean , accumulates in protein storage vacuoles of storage parenchyma cells in cotyledons .
Output: seed lectin
The non - major histocompatibility complex ( MHC ) - encoded CD1 family has recently emerged as a new antigen - presenting system that is distinct from either MHC class I or class II molecules .
Output: CD1 family
The present study also emphasizes the need of establishing dose - response curves to correctly assess the relative contribution of the different regions of steroid hormone receptors in activation of transcription .
Output: steroid hormone receptors
Due to significant homology to the C - terminus of the Mutator transposase this alternative gene product was named Trap ( transposon - associated protein ) .
Output: Mutator transposase
By contrast , footprint II at position - 125 is common to both HeLa and GH3 cell extracts and overlies a 15 - base - pair sequence found in all members of the growth hormone gene family .
Output: growth hormone
In both study stages . post - exposure treatment consisted of five injections of vaccine [ ( D ) ays 0 , 3 , 7 , 14 , 28 ] , together with a dose of rabies immunoglobulin ( RIG ) of equine or human origin on D0 .
Output: rabies immunoglobulin
The coding region of nifA was determined using a translational lacZ fusion and by site - directed mutagenesis to identify which of four in frame AUG codons was used .
Output: lacZ fusion
In the plant malate synthases , the extension is probably involved in routing to the microbodies , since it contains the potential peroxisomal targeting signal , Ser - Arg / Lys - Leu , at the carboxy terminus .
Output: plant malate synthases
The gene atp6 , encoding subunit 6 of the mitochondrial F0 - ATPase complex , has been characterized from both the normal ( fertile ) and Ogura ( male - sterile ) radish cytoplasms in order to determine if previously identified atp6 transcriptional differences could play a role in cytoplasmic male sterility .
Output: gene atp6
However , in a variation of this assay in which the protease is omitted , the mutant enzymes exhibited substantial levels of prolyl isomerase activity ( 5 - 20 % of wild - type ) , revealing that these mutations confer sensitivity to protease digestion and that the classic in vitro assay for prolyl isomerase activity may be misleading .
Output: prolyl isomerase
In the spontaneous abortion group , the levels of PAPP - A were significantly lower than in normal pregnancy but higher than in non - pregnant controls .
Output: PAPP - A
The 5 - HT3 antagonist ondansetron reduced alcohol intake in both the medium and high alcohol preferring rats at doses between 0 . 01 and 0 . 16 mg / kg .
Output: 5 - HT3
We then isolated the full - length coding region of the human BACH1 gene using expressed sequence tags , reverse transcription - polymerase chain reaction and rapid amplification of cDNA ends .
Output: human BACH1 gene
Clinical development of interleukin - 10 .
Output: interleukin - 10
A protein which promotes DNA strand transfer between linear double - stranded M13mp19 DNA and single - stranded viral M13mp19 DNA has been isolated from recA - E . coli .
Output: recA -
An insertion sequence element ( IS1170 ) was identified upstream of the nimC gene .
Output: nimC gene
Two human beta - 1 , 6 - N - acetylglucosaminyltransferases forming the core 2 O - glycan branch , C2GnT and the I antigen , IGnT , are homologous to each other in three regions of the catalytic domain ( A , B , C ) and their genes reside at the same locus , chromosome 9 , band q21 ( Bierhuizen , M . F . A . , Mattei , M . - G . and Fukuda , M . , Genes Dev . , 7 , 468 - 478 , 1993 ) .
Output: I antigen
These studies suggest that tandem alpha - helices located near the C - terminus of PC - TP facilitate membrane binding and extraction of phosphatidylcholines .
Output: PC - TP
Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation .
Output: prolactin receptor
We speculate that the enhancing effect of glucose and galactose on fructose absorption may be due to activation of the fructose carrier .
Output: fructose carrier
Role of zinc - finger proteins Sp1 and zif268 / egr - 1 in transcriptional regulation of the human synaptobrevin II gene .
Output: egr - 1
The Pi signals are conveyed to PHO8 by binding of PHO4 protein , a positive regulatory factor , to a promoter region of PHO8 ( PHO8p ) under the influence of the PHO regulatory circuit .
Output: PHO4 protein
This growth - inhibitory effect was suppressed by the mpk1 delta mutation , suggesting that hyperactivation of the Mpk1 pathway is toxic to cells .
Output: mpk1 delta
The presence of a short ( 70 bp ) intron near the N - terminus of the atX gene was predicted that contains the canonical GT and AG dinucleotides at its 5 ' - and 3 ' - splicing junctions .
Output: atX gene
Both merR genes consist of a 408 bp ORF coding for 135 amino acids .
Output: merR genes
The effect of the negative regulatory element is negated by the viral IE2 protein ( L .
Output: viral IE2 protein
Characterization of a cDNA encoding CNN predicts a novel structural protein with three leucine zipper motifs and several coiled - coil domains exhibiting limited homology to the rod portion of myosin .
Output: cDNA encoding CNN
Isolation and properties of Drosophila melanogaster ferritin - - molecular cloning of a cDNA that encodes one subunit , and localization of the gene on the third chromosome .
Output: Drosophila melanogaster ferritin
Unlike CSK , the SH3 domain of HYL was unique since the ALYDY motif was absent .
Output: SH3 domain
Furthermore , Grap is associated with a Ras guanine nucleotide exchange factor mSos1 , primarily through its N - terminal SH3 domain .
Output: SH3 domain
The human protein binds most strongly to the SH3 domain from the abl proto - oncogene .
Output: SH3 domain
In this study , a site of PDGF - induced tyrosine phosphorylation was mapped to Tyr 138 in the SH3 domain ; Tyr 138 is exposed on the SH3 peptide binding surface .
Output: SH3 domain
A significant difference in the distribution of antibodies to thyroglobulin and thyroid peroxidase was found in subgroup 2 .
Output: thyroid peroxidase
Two different genes ( polA and polB ) encoding family B DNA polymerases were cloned from the organism by PCR using degenerated primers based on the two conserved motifs ( motif A and B ) .
Output: DNA polymerases
Examination of the Coomassie - stained gels revealed that the capsid - like particles composed of the N11 - VP1 protein did not contain any host - derived histones .
Output: N11 - VP1
In addition , mrp17 - 1 , in combination with some mutations affecting another mitochondrial ribosomal protein , caused a synthetic defective phenotype .
Output: mrp17 - 1
These 8 - oxoguanine DNA glycosylases , hOgg1 ( human ) and mOgg1 ( murine ) , are homologous to each other and to yeast Ogg1 .
Output: yeast Ogg1
In cases of intracapsular prostatic cancer the level of prostatic acid phosphatase ( PAP ) measured by radioimmunoassay was 1 . 4 + / - 0 . 8 micrograms / l .
Output: prostatic acid phosphatase
On the basis of experiments with mutant virus and transfection with isolated genes , the herpes simplex virus immediate - early gene product ICP4 is known to positively regulate the transcription of viral early and late genes and negatively regulate expression from its own promoter .
Output: early gene
The IR4 ORF exhibits significant homology to the immediate - early gene US1 ( ICP22 ) of herpes simplex virus type 1 and to the ICP22 homologs of varicella - zoster virus ( ORF63 ) , pseudorabies virus ( RSp40 ) , and equine herpesvirus 4 ( ORF4 ) .
Output: early gene
Vibrio cholerae iron transport : haem transport genes are linked to one of two sets of tonB , exbB , exbD genes .
Output: exbD genes
When the opioid antagonist was administered to animals 24 hr after termination of single or multiple exposures to restraint , NALT - induced increases in basal plasma LH were significantly attenuated in the chronically stressed rats compared to animals subjected to stress only once or not at all . ( ABSTRACT TRUNCATED AT 250 WORDS )
Output: plasma LH
Serum prolactin and oestradiol levels at different stages of puberty .
Output: Serum prolactin
Serum prolactin rapidly decreased after institution of treatment , with actual normalization ( less than 20 ng / ml ) by the 3rd month .
Output: Serum prolactin
Northern analyses further confirm that the expression of endogenous alpha - ENaC gene in salivary Pa - 4 cells is suppressed by an ectopic HMGI - C overexpression .
Output: HMGI - C
The oxalate oxidase method results in a mean and reference interval for oxalate excretion that are comparable with those by isotope dilution , gas - chromatographic , colorimetric , and other enzymic procedures .
Output: oxalate oxidase
Instead , the large difference in ssDNA - binding affinities reflects the loss of hexamerization ability by uvsY , suggesting that a form of intrahexamer synergism or cooperativity between binding sites within the uvsY hexamer leads to its high observed affinity for ssDNA .
Output: uvsY hexamer
A mammalian protein called RFX or NF - X binds to the X box ( or X1 box ) in the promoters of a number of major histocompatibility ( MHC ) class II genes .
Output: NF - X
4 ) Mutation of the three extracellular cysteine residues of GFKAR beta indicated that the two conserved cysteine residues ( C305 and C385 ) , located between two transmembrane segments , form a solvent - accessible disulfide bond .
Output: GFKAR beta
Interestingly , the NES mutant proteins appeared to have altered interactions with the splicing complex , binding more tightly to SC35 in co - immunoprecipitation assays .
Output: NES mutant proteins
Mutations that extend the specificity of the endonuclease activity of lambda terminase .
Output: lambda terminase
Changes in testicular testosterone and acid and alkaline phosphatase activity in testis and accessory sex organs after induction of varicocele in Noble rats .
Output: alkaline phosphatase
The relation between the changes of bone density and the level of blood calcium , blood phosphorus and alkaline phosphatase ( AKP ) as well as the metabolism of vitamin D was studied .
Output: alkaline phosphatase
Surprisingly , in adult animals , the suprabasal expression of dnRXR alpha significantly reduced the ability of topically applied tRA to stimulate proliferation of undifferentiated keratinocytes in the basal layer of epidermis .
Output: dnRXR alpha
They are growth - inhibited by TGF - beta1 .
Output: TGF - beta1
TGF - beta1 induced phosphorylation of Smad2 and Smad3 in Mv1Lu mink lung epithelial cells .
Output: TGF - beta1
This regulation is mediated by several kinases that phosphorylate specific residues in the different functional domains of the p53 molecule .
Output: p53 molecule
Because c - myb encodes a transcriptional activator that functions via DNA binding , it is likely that c - myb exerts its biological activity by regulating the transcription of genes required for DNA synthesis and cell cycle progression .
Output: c - myb
During hexamethylene bisactamide ( HMBA ) - induced differentiation of murine erythroleukemia ( MEL ) cells erythroid genes are transcriptionally activated while c - myb and several other nuclear proto - oncogenes are down - regulated .
Output: c - myb
A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins .
Output: empty spiracles
The increments in median plasma secretin concentration were 1 . 6 , 3 . 0 , and 6 . 4 pmol x 1 ( - 1 ) after secretin , 125 , 250 and 500 fmol x kg - 1 , and the corresponding 15 - min bicarbonate output 283 , 442 , and 1435 micromol , respectively .
Output: plasma secretin
To better understand the relationship between expression of an oncogene and genetic instability , we have studied a cell line expressing an activated human Ha - ras under the control of bacterial lactose operon regulatory elements for changes in methotrexate resistance and dihydrofolate reductase ( dhfr ) gene amplification following mutant Ha - ras induction .
Output: dihydrofolate reductase
Three experiments using 20 microM 2 - ( hydroxyamino ) - 1 - methyl - 6 - phenylimidazo [ 4 , 5 - b ] pyridine ( N - OH - PhIP ) were performed to induce mutations in the dihydrofolate reductase ( DHFR ) gene of a hemizygous Chinese hamster ovary ( CHO ) cell line ( UA21 ) .
Output: dihydrofolate reductase
Paclitaxel caused a rapid and transient increase in c - Jun NH2 - terminal kinase ( JNK ) activity , a proposed mediator of stress activation pathways .
Output: c - Jun
Signal transduction in fibroblasts stably transformed by [ Val12 ] Ras - - the activities of extracellular - signal - regulated kinase and Jun N - terminal kinase are only moderately increased , and the activity of the delta - inhibitor of c - Jun is not alleviated .
Output: c - Jun
Wild type MEKK1 enhances promoter activity and the activity can be inhibited by dominant negative MEKK1 , MEK1 , MEK7 , MEK3 , p38 / RK , and c - Jun .
Output: c - Jun
By deletion analysis , we identified the regions of c - Jun encoding transformation and transactivation functions .
Output: c - Jun
c - Jun protein inhibition occurred via a posttranscriptional mechanism , since tRA did not inhibit UV induction of c - Jun mRNA .
Output: c - Jun
Hematopoietic progenitor kinase 1 ( HPK1 ) is a member of the mitogen - activated protein kinase kinase kinase kinase ( MAP4K ) family and an upstream activator of the c - Jun N - terminal kinase ( JNK ) signaling cascade .
Output: c - Jun
The c - Jun delta - domain inhibits neuroendocrine promoter activity in a DNA sequence - and pituitary - specific manner .
Output: c - Jun
Activated Ki - Ras suppresses 12 - O - tetradecanoylphorbol - 13 - acetate - induced activation of the c - Jun NH2 - terminal kinase pathway in human colon cancer cells .
Output: c - Jun
We have previously described the partial purification of Ap4A hydrolase from S . pombe [ Robinson , de la Pena and Barnes ( 1993 ) Biochim .
Output: Ap4A hydrolase
The amino acid sequence of the protein encoded by MSK1 is homologous to yeast cytoplasmic lysyl - tRNA synthetase and to the product of the herC gene , which has recently been suggested to code for the Escherichia coli enzyme .
Output: herC gene
Mapping the 5 ' and 3 ' termini of TED RNAs indicated that the LTRs have a retroviral U3 - R - U5 structural organization that is capable of directing the synthesis of transcripts that represent potential substrates for reverse transcription and intermediates in transposition .
Output: TED RNAs
In conclusion , ORCA3 regulates jasmonate - responsive expression of the Str gene via direct interaction with the JERE .
Output: Str gene
Production of VT was also examined retrospectively in 32 E . coli strains of serotype O26 : H11 isolated from children with diarrhoea ; eight ( 25 % ) of them produced moderate to high levels of verotoxin 1 despite several years storage in vitro .
Output: verotoxin 1
In the normal controls the plasma FPA level ( mean + / - SD ) was 1 . 43 + / - 0 . 46 ng / ml .
Output: plasma FPA
ALT ( alanine aminotransferase ) and Hb ( hemoglobin ) appeared to be predictive for efficacy .
Output: alanine aminotransferase
The H5 mutants were : DH5 ( all amino acids in D configuration ) and H5F ( where all His are replaced by Phe at positions 3 , 7 , 8 , 15 , 18 , 19 , 21 ) .
Output: H5 mutants
In an effort to identify factors involved in the expression of this important erythroid - specific regulatory protein , we have isolated the mouse EKLF gene and systematically analyzed the promoter region .
Output: mouse EKLF gene
During the burst period ( approximately 5 - 10 min ) , local blood H2O2 concentrations and xanthine oxidase activities were highly correlated ( r = 0 . 999 ) .
Output: xanthine oxidase
Like other known GCD genes , GCD14 and GCD15 are therefore probably required for general translation initiation in addition to their roles in GCN4 - specific translational control .
Output: GCD genes
A constructed phylogenetic tree suggests that the UbcP1 protein may represent a member of a distinct subfamily of E2s .
Output: UbcP1 protein
However , an analogous myristoylated peptide derived from c - Yes also has no inhibitory activity .
Output: c - Yes
Structure and regulation of KGD2 , the structural gene for yeast dihydrolipoyl transsuccinylase .
Output: yeast dihydrolipoyl transsuccinylase
Sgs - 4 is one of the eight known genes coding for larval secretion proteins in Drosophila melanogaster .
Output: Sgs - 4
The addition of novel techniques , such as histopathologic ultrastaging , immunohistochemistry staining , and reverse transcriptase polymerase chain reaction assays , will help increase the accuracy and rate of detection of disease .
Output: reverse transcriptase
There was a 57 % reduction in IGF IR mRNA levels in clone CA9 after confluence compared with clone ME10 .
Output: IGF IR mRNA
We cloned the BamHI - F fragment from the left end of Ad4 in pUC13 - 1 between the SalI and BamHI sites in order to carry out the structural analysis of the E1A region of Ad4 .
Output: BamHI sites
In agreement with this , archaea appear to lack eIF5 , eIF2B and the lysine - rich binding domain for these factors in their eIF2beta homolog .
Output: eIF2beta homolog
The CydDC system appears to be the first prokaryotic example of a heterodimeric ABC transport system in which each polypeptide contains both hydrophobic and ATP - binding domains .
Output: CydDC system
A . nidulans transformants secreted high amounts of PGI and PGII in comparison to the previously characterized A . niger transformants and a novel polygalacturonase ( PGC ) was produced at high levels by A . nidulans transformed with the subcloned pgaC gene .
Output: pgaC gene
Previous studies have shown that TGFbeta1 expression is upregulated in mouse keratinocytes infected with a v - rasHa retrovirus , although the functional significance of this has not been clear .
Output: v - rasHa
Acetoacetate decarboxylase ( ADC ) ( EC4 . 1 . 1 . 4 ) of Clostridium acetobutylicum DSM 792 was purified to homogeneity , and its first 25 N - terminal amino acids were determined .
Output: Acetoacetate decarboxylase
To examine the biochemical mechanism of Tax1 transactivation , we have developed an in vitro transactivation assay in which wild - type Tax1 is able to specifically transactivate a polymerase II promoter through upstream Tax1 - responsive elements .
Output: polymerase II
Previous analysis of this motif in the lactose permease ( A .
Output: lactose permease
Human and murine cytotoxic T lymphocyte serine proteases : subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins .
Output: serine proteases
This is consistent with the need for a nuclear retinoid receptor function in RA - induced ERK2 activation .
Output: retinoid receptor
The nucleoporin 98 gene ( NUP98 ) , which is rearranged in several acute myeloid leukemia translocations , is located within this region .
Output: nucleoporin 98 gene
The point mutation Asp - 316 - - > Asn in the C - terminus of p38 , analogous to the ERK2 ( extracellular - signal - regulated kinase 2 ) sevenmaker mutation , dramatically decreases its binding to MKP - 1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase .
Output: MKP - 1
Here we report the cloning of the hemF gene , encoding the aerobic coproporphyrinogen III oxidase from Escherichia coli , by functional complementation of a Saccharomyces cerevisiae HEM13 mutant .
Output: hemF gene
Characterization of a nuclear deformed epidermal autoregulatory factor - 1 ( DEAF - 1 ) - related ( NUDR ) transcriptional regulator protein .
Output: DEAF - 1
Strains carrying a snf1 mutation are unable to grow on sucrose , galactose , maltose , melibiose , or nonfermentable carbon sources ; utilization of these carbon sources is regulated by glucose repression .
Output: snf1 mutation
Gene GPR 51 was localized by radiation hybrid mapping to chromosome 9 , 4 . 81 cR from the WI - 8684 marker , and proximal to the hereditary sensory neuropathy type 1 locus .
Output: Gene GPR 51
Coexpression of CREB - binding protein ( CBP ) / p300 with TReP - 132 has an additive effect on promoter activity , and the proteins were demonstrated to interact physically .
Output: TReP - 132
Here we investigate the mechanism of TPA induction of FGF - BP gene expression in the human ME - 180 SCC cell line .
Output: FGF - BP
Sequential immunoprecipitation showed all detectable p53 to be of the PAb246 + class in each LPV - transformed cell line , suggesting that the stable p53 was indeed wild type .
Output: PAb246 +
With this study , a total of 13 operators for the glp regulon have been characterized .
Output: glp regulon
This mechanism seems to be involved in VIP - induced PRL gene regulation .
Output: PRL gene
To clarify the difference , both the Crk II and Crk II - 23 , proteins were expressed in E . coli and examined their binding capacity in vitro .
Output: Crk II
Of 3841 serum samples from sows received from the Tennessee State Diagnostic Laboratory in 1991 - 1992 , 1130 were positive for Toxoplasma gondii antibody .
Output: Toxoplasma gondii antibody
Reaction of aromatic / heterocyclic sulfonamides possessing free amino , imino or hydrazino moieties with 7 - chloro - 4 - chloromethylcoumarin afforded a series of N - [ ( 7 - chloro - 4 - coumarinyl ) - methyl ] - derivatives which showed effective inhibition of three carbonic anhydrase ( CA ) isozymes .
Output: carbonic anhydrase
Foamy viruses ( FVs ) express the Gag protein as a precursor with a molecular mass of 74 kDa ( pr74 ) from which a 70 - kDa protein ( p70 ) is cleaved by the viral protease .
Output: Gag protein
This integration results in the production of MMTV / mdr3 fusion transcripts that originate from the antisense 5 ' LTR of the provirus .
Output: 5 ' LTR
In K562 cells , using the bicistronic vector , selection with colchicine led to at least 20 - fold higher expression of the MDR1 gene product than did selection with G418 , suggesting that the stringent MDR1 selection system is very efficient for obtaining overexpression of foreign genes .
Output: MDR1 gene product
The cloned rRNA operon was transcribed in vitro by using purified RNA polymerase of Escherichia coli .
Output: RNA polymerase
The deduced gene product was found to have significant sequence similarity to the yeast and prokaryotic RNA polymerase subunits involved with subunit assembly .
Output: RNA polymerase
The biological activity of these mutants was tested by determining their capacity to ( i ) reconstitute RNA polymerase activity in vivo by cotransfection with proteins NP , PB1 , and PA and a virion - like RNA encoding the cat gene into vaccinia virus T7 - infected COS - 1 cells and ( ii ) complete with the wild - type PB2 activity .
Output: RNA polymerase
Biochemical experiments and genome sequencing have shown that , despite the prokaryotic cell and genome organization , basal transcriptional elements of members of the domain Archaea ( i . e . , TATA box - like sequences , RNA polymerase , and transcription factors TBP , TFIIB , and TFIIS ) are of the eukaryotic type .
Output: RNA polymerase
The phosphatidylglycerol / phosphatidylinositol transfer protein ( PG / PI - TP ) is a new and original phospholipid transfer protein ( PLTP ) isolated from the Deuteromycete , Aspergillus oryzae .
Output: phospholipid transfer protein
A high titer of anti - HBc , thus suggested to be an indicator of persistent hepatitis B virus infection , was found rarely in seronegative patients with chronic hepatitis , non - alcoholic cirrhosis , or alcoholic liver diseases .
Output: anti - HBc
Fig1p and Fig2p are likely to act at the cell surface as Fig1 : : beta - gal and Fig2 : : beta - gal fusion proteins localize to the periphery of mating cells .
Output: beta - gal
Our results admit that a ribosome scanning mechanism of the MP gene expression from I ( 2 ) sgRNA operates concurrently .
Output: MP gene
Expression of putative constitutively active forms of DdMEK1 in a ddmek1 null background is capable , at least partially , of complementing the small aggregate size defect and the ability to activate guanylyl cyclase .
Output: guanylyl cyclase
The MIC90 of ABK against coagulase type IV strains was rather high , 12 . 5 micrograms / ml .
Output: coagulase type IV
We have previously identified LIT1 , a paternally expressed antisense RNA within the KvLQT1 locus through a positional screening approach using human monochromosomal hybrids .
Output: KvLQT1 locus