niryuu/sni-each-converted huggingface dataset:
In vitro death assays with transient overexpression of deletion constructs of both isoforms using beta - galactosidase as a reporter gene in MCF7 cells suggest the following : 1 ) the nucleotide binding domain may act as a negative regulator of the killing activity of DEFCAP ; 2 ) the LRR / CARD represents a putative constitutively active inducer of apoptosis ; 3 ) the killing activity of LRR / CARD is inhibitable by benzyloxycarbonyl - Val - Ala - Asp ( OMe ) - fluoromethyl ketone and to a lesser extent by Asp - Glu - Val - Asp ( OMe ) - fluoromethyl ketone ; and 4 ) the CARD is critical for killing activity of DEFCAP .
Output: beta - galactosidase
To identify and determine the function of Ino2p in yeast cells , we raised antibodies to a beta - galactosidase / Ino2 fusion protein .
Output: beta - galactosidase
Cellular lysates were analyzed for luciferase and beta - galactosidase activities .
Output: beta - galactosidase
Mutations in the beta - galactosidase gene result in the lysosomal storage disorders GM1 - gangliosidosis and Morquio B syndrome .
Output: beta - galactosidase
A rabbit antiserum raised against a unique ( V3 domain ) bacterially expressed PKC theta fragment immunoprecipitated specifically an 82 - kDa protein from Jurkat cell lysates .
Output: PKC theta fragment
Mammalian homologues of the Polycomb - group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S . cerevisiae telomeres .
Output: Enhancer of zeste
In the fungus Neurospora crassa , nit - 2 , the major nitrogen regulatory gene , activates the expression of unlinked structural genes that specify nitrogen - catabolic enzymes during conditions of nitrogen limitation .
Output: nit - 2
No patient demonstrated a decrease in bone marrow fibrosis as determined by serial procollagen ( PC III ) serum level analysis .
Output: PC III
Furthermore , we detect hCoch - 5B2 on three overlapping YACs , two of which also contain one of the markers linked to DFNA9 .
Output: hCoch - 5B2
The cyanobacterial phycobilisome is a large protein complex located on the photosynthetic membrane .
Output: cyanobacterial phycobilisome
IGF - I levels were measured in the CSF of 11 children with autism ( 4 females , 7 males ; mean age 3 . 8 years , SD 1 . 1 ) using a sensitive radioimmunoassay method and compared with levels in 11 control participants ( 6 females , 5 males ; mean age 3 . 8 years ) .
Output: IGF - I
Despite the fact that biochemical estimates of bone turnover indicate that ( short - term ) administration of rhGH and IGF - I stimulates bone metabolism in non - osteoporotic older people , no significant changes have been observed in bone mineral density at the proximal femur .
Output: IGF - I
METHODS : The prevalence of haemagglutination inhibiting ( HI ) antibodies to JE virus ( JEV ) , West Nile virus ( WNV ) and dengue - 2 virus ( DEN - 2 ) was detected by HI test and IgM antibody capture ELISA ( MAC ELISA ) was performed to determine recent infections with JE virus .
Output: IgM antibody
The potential biological significance of the identified structural motif shared by the human CCR5 , CCR3 , CCR2B and other GPCRs is discussed .
Output: human CCR5
Primers were developed for specific amplification of 9804 gene fragments .
Output: 9804 gene fragments
In contrast , no change in the level of either p53 or activation of mdm2 protein by p53 was observed in hamster UV61 cells after UV exposure .
Output: mdm2 protein
Since RIP140 generally down - regulates receptor activity in mammalian cells and specifically down - regulates coactivation mediated by SRC - 1 , we propose a model in which RIP140 indirectly regulates nuclear receptor AF - 2 activity by competition for coactivators such as SRC - 1 .
Output: SRC - 1
It also showed which amino acid residues would contact an extended TATA box with a B recognition element , and evolutionary conservation of the TBP - TFB - DNA complex orientation between two archaeal organisms with widely different optimal temperature for growth ( 37 and 100 degrees C ) .
Output: B recognition element
Evidence for involvement of proteins HU and RpoS in transcription of the osmoresponsive proU operon in Escherichia coli .
Output: proU operon
Mutations in nifR1 ( ntrC ) and nifR4 ( rpoN , encoding sigma54 ) had no influence on xdh gene expression .
Output: xdh gene
As much thrombin was formed during cardiopulmonary bypass ( measured by the prothrombin activation fragment F1 + 2 and thrombin - antithrombin complexes ) as in normal patients , showing that factor XII was not necessary for thrombin generation .
Output: factor XII
RXRalpha / RARalpha heterodimers and HNF - 4 homodimers bind to DR - 1 motifs on elements B and I4 , respectively .
Output: HNF - 4
In the studies described in this report , we have identified two potential Ets binding sites , EBS1 and EBS2 , which are conserved in both the human and murine interleukin - 2 enhancers .
Output: interleukin - 2
In T cells these two signal pathways are critical for interleukin - 2 production .
Output: interleukin - 2
In this study , we sought to determine the specific effect of HIV protease inhibitors on patient weight .
Output: HIV protease
The level of expression of the PDE protein was monitored by immunoblot analysis using two specific cAMP - PDE polyclonal antibodies and by measuring the PDE activity .
Output: PDE protein
Some of these DNA : protein complexes were also present , but at lower levels , in nuclear extracts from untransformed rat cells suggesting the possible involvement of cellular factors in the mechanism of down - regulation mediated by Ad12 E1A .
Output: Ad12 E1A
The IB2 gene ( HGMW - approved symbol MAPK8IP2 ) maps to human chromosome 22q13 and contains 10 coding exons .
Output: IB2 gene
Transcripts appear to be initiated from an upstream promoter , P1 , located in front of the tRNA ( met1 ) gene and from three internal promoters : P2 is located immediately in front of the tRNA ( met2 ) gene ; PL10 is near the beginning of the L1 - L10 intergenic space , and PL12 is at the end of the L10 gene sequence .
Output: L10 gene sequence
Despite this loss , YEpFAS1 is still able to complement a fas1 mutation at the enoyl reductase domain .
Output: enoyl reductase
The control of human aromatase expression is complex in that several promoters drive aromatase expression in a tissue - specific manner .
Output: human aromatase
Using unidirectional PCR we isolated a 361 - bp 5 ' promoter region and delineated the intronic / exonic boundaries which include a non - coding exon 1 , a single intron , and a coding exon 2 , a structure that is typical of genes of the RNase A superfamily .
Output: RNase A superfamily
A lead phthalocyanin method for the demonstration of acid hydrolases in plant and animal tissues .
Output: acid hydrolases
Indeed , after a single oral dose , the role of the mu - receptor agonist component of the antinociceptive effect of tramadol appears to be minor , with most of the analgesic effect being attributable to nonopioid properties of the parent compound .
Output: mu - receptor
In agreement with this model , elimination of the ADAM13 cytoplasmic domain increased developmental alterations attributable to ADAM13 proteolytic activity .
Output: ADAM13 cytoplasmic domain
The NrfC polypeptide , M ( r ) 24 , 567 , contains 16 cysteine residues arranged in four clusters typical of the CooF super - family of non - haem iron - sulphur proteins .
Output: NrfC polypeptide
The Fugu rubripes ( Fugu ) gene fragment was used to isolate the GH gene from a Fugu genomic library .
Output: GH gene
We have analyzed the role of the HU protein in invertasome assembly when the enhancer is located at variable positions close to one of the recombination sites .
Output: HU protein
As exogenously expressed PKR can form heterodimers with endogenous PKR , the results obtained on the functional characterization of mutant forms of PKR have been taken with caution .
Output: endogenous PKR
In rats exposed to Cd for 30 d , the levels of urinary excretion of cAMP after treatment with parathyroid hormone ( PTH ) , parathyroidectomy ( PTX ) , or 1 alpha - hydroxycholecalciferol ( 1 alpha - OH - D3 ) showed almost the same patterns as those of control rats : the response of urinary cAMP to treatment with PTH was not influenced by continuous oral administration of Cd .
Output: parathyroid hormone
In gel mobility shift assays , high binding activities of ATPC - 2 and low binding activities of CBF were observed with nuclear extracts from tissue with low AtpC expression levels , and the opposite was observed with extracts from tissues with high AtpC expression levels .
Output: ATPC - 2
The most frequent abnormality was GH deficiency ( six cases ) , followed by gonadotropin ( four cases ) , cortisol ( four cases ) , and TSH ( one case ) , whereas four patients showed high serum PRL values .
Output: serum PRL
We recently described the isolation and characterization of nontoxic PAP mutants , NT123 - 2 , which has a point mutation ( E176V ) in the active site that abolishes enzymatic activity , and NT124 - 3 , which has a nonsense mutation that results in deletion of the C - terminal 25 aa ( W237Stop ) .
Output: PAP mutants
We conclude that a 0 . 25 mg dose of triazolam does not effectively counteract a posture - induced sleep disturbance , but induces changes in the EEG spectra which are typical for benzodiazepine receptor agonists .
Output: benzodiazepine receptor
Iomazenil - SPECT revealed a highly significant increase in the benzodiazepine receptor uptake in all studied cortical regions except temporal cortices .
Output: benzodiazepine receptor
The relationship between CSF somatostatin and peripheral thyroid hormones was assessed in 11 affectively ill patients before and during carbamazepine treatment .
Output: CSF somatostatin
Internal controls over the volume of milk suckled do not appear until infant rats are about 2 weeks of age at which time gastric distension , milk , systemic dehydration , and intestinal hormone cholecystokinin suppress milk intake derived through suckling .
Output: intestinal hormone cholecystokinin