niryuu/sni-each-converted huggingface dataset:
It is concluded that the predominant action of LSD on the female copulatory response is not mediated by increased dopamine receptor activity but that the LSD effect might be modulated by decreased dopaminergic activity .
Output: dopamine receptor
claR and car were not significantly expressed in mutants disrupted in the ccaR gene , a regulatory gene that controls positively clavulanic acid and cephamycin biosynthesis .
Output: ccaR gene
RNase protection analysis reveals a 10 - fold increase in the expression of SCD2 mRNA during 3T3 - L1 preadipocyte differentiation .
Output: SCD2 mRNA
The levels of TPAR1 mRNAs were dramatically down - regulated in regenerating rat liver when compared to normal adult liver .
Output: TPAR1 mRNAs
Furthermore , the data suggest an immunological non - responsiveness to enterotoxin A in a considerable portion of the patients .
Output: enterotoxin A
Further studies aim at characterizing the trans - acting factors that mediate the spatial and temporal expression of Hox genes in the developing embryo .
Output: Hox genes
Sugar analysis was performed on alpha - TM to investigate a possible biosynthetic mechanism for part - time PGs .
Output: alpha - TM
P53 mutations also offer new approaches to the study of the origins of mutations in human cancer .
Output: P53 mutations
In situ hybridization of whole - mount mouse embryos with Mex5 antisense RNA provide no evidence for the exclusion of Mex5 during embryonic development .
Output: Mex5 antisense RNA
The sequence of the 127 residue NrfF polypeptide , M ( r ) 14 , 522 , is strikingly similar to the CcI2 protein of R . capsulatus , especially in the putative haem - binding motif , RCPQCQNQN . ( ABSTRACT TRUNCATED AT 400 WORDS )
Output: CcI2 protein
A novel Cdc42Hs mutant induces cellular transformation .
Output: Cdc42Hs mutant
The vaccinia virus D6R open reading frame encodes the small subunit of the heterodimeric vaccinia virus early transcription factor ( VETF ) that activates transcription of early genes in vitro .
Output: early genes
In addition , Fc epsilon R1 cross - linking activates PI 3 - kinase .
Output: Fc epsilon R1
Its phosphorylation strongly potentiates its ability to activate transcription of the c - fos promoter through a ternary complex assembled on the c - fos serum response element .
Output: c - fos
Basic helix - loop - helix proteins can act at the E - box within the serum response element of the c - fos promoter to influence hormone - induced promoter activation in Sertoli cells .
Output: c - fos
Rac2 , a member of the Rho family of GTPases , is highly expressed in myeloid cells and is a regulator of the NADPH - oxidase complex .
Output: Rho family
RESULTS : All primary tumors were positive for CAM5 . 2 .
Output: CAM5 . 2
Serum angiogenin concentrations in young patients with diabetes mellitus .
Output: Serum angiogenin
When severe hypoxia was acutely produced by ventilation with low - oxygen mixtures in experimental ( PaO2 , 23 . 7 + / - 1 . 7 torr ) and control animals ( PaO2 , 26 . 3 + / - 1 . 0 torr ) , plasma insulin responses were markedly inhibited in both .
Output: plasma insulin
Effect of age on glucose , reducing sugars and plasma insulin in blood of milk - fed calves .
Output: plasma insulin
The full - length cDNA was cloned and sequenced , and the inferred amino acid sequence was found to encode a novel protein , which we named cystatin M , with 40 % homology to human family 2 cystatins and similar overall structure .
Output: cystatin M
These cells also showed an increase in cyclin A and cyclin A - and E - associated kinase activities characteristic of S phase induction .
Output: cyclin A
The PRP4 protein of Saccharomyces cerevisiae is an essential part of the U4 / U6 snRNP , a component of the mRNA splicing apparatus .
Output: PRP4 protein
METHODS : Levels of sIL - 2R were measured simultaneously in plasma and pleural fluid in 111 patients with pleural effusions of unknown causes .
Output: sIL - 2R
After 3 months of intervention , sustained physical training was associated with the decrease of FVII and PAI - 1 levels .
Output: PAI - 1
High and pathological PAI - 1 levels before and after the VO test were consistent with a defective fibrinolytic potential due to the inhibitory effect of PAI - 1 on plasminogen activation .
Output: PAI - 1
The remaining 77 nucleotides at the 3 ' end of domain II and all of domains III ( 655 nucleotides ) and IV ( 770 nucleotides ) are not present in DIssE RNA .
Output: DIssE RNA
Serum alpha - amylase , trypsin , trypsin inhibitor , lipase and total protease activity in the pancreatic tissue was studied as indicator of the treatment efficacy with 5 - fluorouracil electro - cumulation .
Output: trypsin inhibitor
Nicotinic receptor antagonists mecamylamine ( 0 . 5 and 1 mg / kg ) and hexamethonium ( 5 and 10 mg / kg ) reduced the response induced by nicotine ( 0 . 25 mg / kg ) .
Output: Nicotinic receptor
Comparison of the encoded ERCC3Dm protein with the homologous proteins of mouse and man shows a strong amino acid conservation ( 71 % identity ) , especially in the postulated DNA binding region and seven ' helicase ' domains .
Output: ERCC3Dm protein
BACKGROUND - - Platelet activating factor ( PAF ) has been implicated in the pathogenesis of airway hyperresponsiveness in asthma .
Output: Platelet activating factor
Although several other signal transduction molecules also contain tandemly occurring SH3 and SH2 domains , the function of these closely spaced domains is not well understood .
Output: SH2 domains
In addition , putative binding sites for SH3 and SH2 domains are present in the amino - terminal half of the molecule .
Output: SH2 domains
Detailed comparison of the sequences of cp35 and human calpactin II shows that the only substantial sequence dissimilarity is a domain encoding amino acids between residues 20 and 40 which includes a tyrosine phosphorylation site in the human molecule , along with other residues of possible physiological significance .
Output: human calpactin II
We provided evidence that CaM kinase II played a role in regulating neurite outgrowth and growth cone motility in these cells , and that the autophosphorylation is essential for the kinase to sufficiently exert its cellular function in vivo [ Y .
Output: CaM kinase II
When yeast cells reach a critical size in late G1 they simultaneously start budding , initiate DNA synthesis , and activate transcription of a set of genes that includes G1 cyclins CLN1 , CLN2 , and many DNA synthesis genes .
Output: G1 cyclins
Thus , an unmodified threonine at position 169 in Cdc28 is important for interaction with G1 cyclins .
Output: G1 cyclins
The predicted amino - acid sequence includes an N - terminal signal sequence of 27 amino acids , a 27 amino - acid pro - region , a 251 amino - acid catalytic domain typical of a serine protease with trypsin - like specificity , and a C - terminal hydrophobic extension which is predicted to function as a membrane anchor .
Output: serine protease
In those patients who before transplantation were serological negative for CMV but had received organs from CMV - IgG positive donors , the incidence of the disease was highest .
Output: CMV - IgG
The TCR beta enhancer was active on both the minimal simian virus 40 promoter and a TCR beta variable gene promoter in both TCR alpha / beta + and TCR gamma / delta + T cells .
Output: TCR beta enhancer
The genomic organization in this region is similar to the neural - restricted family members , Hel - N1 ( ELAVL2 ) and mHuD ( Elavl4 ) .
Output: Hel - N1
Analysis of pseudo VH gene segment recombination products reveals no bias in D gene segment reading frame utilization .
Output: D gene segment
Detailed analysis of the predicted amino acid sequence revealed sequence elements which are conserved in many DNA and RNA polymerases .
Output: RNA polymerases
Rhinovirus 2A protease and foot - and - mouth - disease virus L protease were used to analyze the association of eIF4G with eIF4A , eIF4E , and eIF3 .
Output: Rhinovirus 2A protease
We now show that purified recombinant c - sis / PDGF can induce this binding activity which we have termed SIF , for sis - inducible factor .
Output: c - sis
These proteins , called variant surface glycoproteins ( VSGs ) , are expressed from a specific locus , the VSG gene expression site ( ES ) .
Output: variant surface glycoproteins
Recombinant protein encoded by ESX ( for epithelial - restricted with serine box ) exhibits Ets - like DNA binding specificity in electrophoretic mobility shift assays and , in transient transfection assays , transactivates Ets - responsive promoter elements including that found in the HER2 / neu oncogene .
Output: Ets - like
Immunoblot analysis of purified and protease - digested intracellular mature virus ( IMV ) and extracellular enveloped virus ( EEV ) showed that the A36R proteins were present on the surface of EEV with type II membrane topology , but were absent from IMV .
Output: A36R proteins
Among women , plasma factor VII : Ag was inversely associated with income .
Output: plasma factor VII
To initiate our analysis of factors required for eIF - 2 alpha expression , selected a CAP - proximal element shown by in vivo methylation protection analysis to bind a potential regulatory factor .
Output: eIF - 2
A wide conservation of iscSUA genes in nature and evidence that NifU and NifS participate in the mobilization of iron and sulfur for nitrogenase - specific iron - sulfur cluster formation suggest that the products of the iscSUA genes could play a general role in the formation or repair of iron - sulfur clusters .
Output: iscSUA genes
In addition , mutations within the Ubx unit exons are known and most of these behave as null alleles .
Output: Ubx unit exons
The authors suggest that alprazolam may have enhanced specificity for a subpopulation of benzodiazepine receptors .
Output: benzodiazepine receptors
Interestingly , unlike PAK65 , HPK1 does not contain the small GTPase Rac1 / Cdc42 - binding domain and does not bind to either Rac1 or Cdc42 , suggesting that HPK1 . activation is Rac1 / Cdc42 - independent .
Output: small GTPase
We functionally characterised AtXPO1 by its interaction with NESs of animal and plant proteins , which is inhibited by the cytotoxin leptomycin B ( LMB ) , and also by its interaction with the small GTPase Ran1 in the yeast two - hybrid system .
Output: small GTPase
Therefore , it appears that GCN2 protein kinase function is stimulated posttranslationally in amino acid - starved cells .
Output: GCN2 protein kinase
From the deduced amino acid sequence , a molecular weight of 38 , 549 was calculated for the ADH subunit .
Output: ADH subunit
The analysis predicted that progressive increases in serum creatinine or aspartate transaminase activity will result in only a 50 % reduction of clearance .
Output: aspartate transaminase
In contrast , the holo - dTFIIA ( L / S ) binds TBP with high affinity .
Output: holo - dTFIIA
Prematurely inactivating p42 MAPK in egg extracts resulted in a corresponding hastening of the first mitosis .
Output: p42 MAPK
Suppression of the cka1 delta cka2 - 8 mutant phenotype occurs by interaction of CKB1 with the defective , cka2 - 8 - encoded , catalytic subunit .
Output: cka2 - 8
Previous studies showed that a palindromic sequence located at - 159 base pairs is essential for induction of cutinase gene in Fusarium solani f .
Output: cutinase gene
Given a rapid induction of Egr - 1 on stimulation with growth factors or injury , these findings may represent at least one of the molecular mechanisms underlying phenotypic modulation of smooth muscles after vascular injury .
Output: Egr - 1
The originally embryonic gamma - globin locus duplicated and acquired a novel ( fetal ) pattern of expression in a defined time period ( 55 - 40 million years ago ) during primate phylogeny .
Output: gamma - globin
Analysis of the 5 ' and 3 ' termini of the transcripts produced in vivo from the puf operon of R . sphaeroides PUF delta 348 - 420 ( three transcripts ; 0 . 59 , 0 . 64 , and 2 . 63 kilobases ) lacking the puf - intercistronic terminator structure were identical to those of the corresponding puf transcripts derived from wild - type R . sphaeroides 2 . 4 . 1 ( four transcripts ; 0 . 50 , 0 . 66 , 0 . 71 , and 2 . 7 kilobases ) showing that the transcripts begin and end at the same sites .
Output: puf transcripts
BACKGROUND : Peripheral kappa receptor agonists may provide a new therapeutic approach for the treatment of functional dyspepsia .
Output: kappa receptor
Using green fluorescent protein fusions we demonstrate that the SYT , SSX and the SYT - SSX proteins are nuclear proteins .
Output: green fluorescent protein
K562 erythroleukemia cells stably transfected with constructs containing the human Agamma - globin promoter linked to an enhanced green fluorescent protein ( EGFP ) reporter , with or without HS2 , were analyzed for EGFP expression by flow cytometry .
Output: green fluorescent protein
Paradoxically , loop 3i from the M1Ach - muscarinic receptor also maximally inhibited GnRH agonist - stimulated cAMP accumulation and PRL release by 40 % ( both effects mediated through activation of the Gs protein ) .
Output: Gs protein
We identified Tyr ( 112 ) and Leu ( 175 ) within the RNA - binding domain of the U1 70K protein to be cross - linked to G ( 28 ) and U ( 30 ) in stem - loop I , respectively .
Output: U1 70K protein
A wound model for decubitus and leg ulcers consisting of human dermal fibroblasts in type I collagen dermal " equivalent " matrix ( DEM ) was exposed in vitro to electric fields similar to postulated endogenous fields in wounds .
Output: type I collagen
We conclude from these observations that the cTnC 3 ' Ile element is a composite enhancer that functions through the combined interactions of at least five regulatory elements and their cognate binding factors : three or four E - boxes , a MEF - 2 site , and a MEF - 3 site .
Output: MEF - 2
The MEF - 2 proteins are a family of transcriptional activators that have been detected in a wide variety of cell types .
Output: MEF - 2
Oligomers corresponding to the region of the mlc - 1 / 3 enhancer , which encompasses this conserved sequence , bound MEF - 2 and competed for its binding to the mck enhancer .
Output: MEF - 2
These morphological changes are associated with a marked induction of P450arom gene expression .
Output: P450arom gene
We have previously reported the first isolation of a c - myc - null cell line .
Output: c - myc
Mad3 and Mad4 : novel Max - interacting transcriptional repressors that suppress c - myc dependent transformation and are expressed during neural and epidermal differentiation .
Output: c - myc
ER and DR were significantly correlated with MIB - 1 LI ( P < 0 . 01 and P < 0 . 05 , respectively ) , but RI and Td / Te were not .
Output: MIB - 1
The proliferative potential of the pilocytic astrocytoma : the relation between MIB - 1 labeling and clinical and neuro - radiological follow - up .
Output: MIB - 1
We concluded that RXR - gamma induced terminal differentiation in SCC lines , suggesting a potential tumor suppressor function for this transcription factor .
Output: RXR - gamma
Although they are similar to the IL9R gene ( approximately 90 % identity ) , none of these copies encodes a functional receptor : none of them contains sequences homologous to the 5 ' flanking region or exon 1 of the IL9R gene , and the remaining ORFs have been inactivated by various point mutations and deletions .
Output: IL9R gene
Plasma renin activity in end - stage kidney disease .
Output: Plasma renin
Plasma renin activity in essential arterial hypertension .
Output: Plasma renin
Furthermore , the induction of cytochrome P - 450 1A1 observed in the cormorant indicates that the Ah receptor - mediated process , by which TCDD and related chemicals exert many of their toxicities , has been activated .
Output: Ah receptor
The analysis of the effects of eight signaling molecules in the TGFbeta , FGF , Hh , Wnt , and EGF families in tooth explant cultures revealed that the expression of edar was induced by activinbetaA , whereas Wnt6 induced ectodysplasin expression .
Output: EGF families
Sequences within the UAS2 element of the ENO2 gene bound a second protein which corresponded to the ABFI ( autonomously replicating sequence - binding factor ) protein .
Output: ENO2 gene
This action could be antagonized by aminophylline , a competitive antagonist on P1 purinoceptors .
Output: P1 purinoceptors
We identified clones of Chlamydomonas genomic DNA that rescued the Ca ( 2 + ) - dependent axonemal microtubule severing defect of fa1 mutants .
Output: fa1 mutants
Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses .
Output: CCR5 genes
CYP51P1 is 96 . 5 % identical to the human CYP51 coding sequence and is not interrupted with introns but has six in - frame stop codons resulting from point mutations .
Output: human CYP51
This complex was eliminated by mutation of either half - site , and it was supershifted by antibodies against chicken ovalbumin upstream promoter - transcription factor ( COUP - TF ) .
Output: COUP - TF
In contrast , the sequences essential for the transcription of EFT1 were localized to the region between the start ATG and the stop codon of the VPS17 gene that terminates 267 nt upstream on the same strand .
Output: VPS17 gene
The Tat protein coded by human immunodeficiency virus ( HIV ) is a strong activator of viral gene expression from the long terminal repeat ( LTR ) .
Output: Tat protein
Similar tissue - specific patterns are observed with a fusion between the caufliflower mosaic virus 35S RNA promotor and the GUS gene .
Output: GUS gene
Postheparin lipoprotein lipase , measured using fat emulsion as substrate , also was significantly greater in female rats compared with males .
Output: lipoprotein lipase
Molecular cloning of cDNAs encoding alpha - subunits of guanine nucleotide - binding regulatory proteins ( G - proteins ) has revealed the existence of nine species of alpha - subunits .
Output: G - proteins
Heterotrimeric guanine nucleotide - binding proteins ( G - proteins ) function as signal transducers for a variety of hormone - coupled enzyme and ion transport systems in eukaryotic cells .
Output: G - proteins
A DNA fragment that complements the uvs - 2 mutation was subcloned by monitoring its ability to transform the uvs - 2 mutant to MMS resistance .
Output: uvs - 2
These data may indicate redundancy between members of the NGFI - B / Nurr1 / Nor1 subfamily and could explain why no phenotypic disturbances have yet been found in mice in which the NGFI - B gene has been inactivated .
Output: NGFI - B
The N - terminal exon1 had no homology at the amino acid level with NGFI - B , the mammalian homologue .
Output: NGFI - B
The secondary end points included creatine kinase peak , ventricular fibrillation / tachycardia within the first 24 hours , death and congestive heart failure within the 30 - day follow - up , and 30 - day left ventricular ejection fraction .
Output: creatine kinase
To explore further the role of the carboxyl - terminal domain in determining the cell cycle function of CDC34 , we constructed and characterized genes encoding chimeric E2s incorporating sequences from CDC34 and the related but functionally distinct E2 RAD6 ( UBC2 ) .
Output: chimeric E2s
The two complexes were detected with a similar activation kinetics upon IL - 4 stimulation .
Output: IL - 4
Analysis of 1 Mb of published sequence from the region of conserved synteny on human chromosome 5q31 - q33 identified 45 gene candidates , including 35 expressed genes in the human IL - 4 cytokine gene cluster .
Output: IL - 4
In this report , we identify Tyr319 as a functionally important phosphorylation site in the ZAP - 70 interdomain B region .
Output: ZAP - 70
Here we demonstrate that the T cell antigen receptor zeta - chain - associated ZAP - 70 kinase and T cell antigen receptor zeta - chain immunoreceptor tyrosine - based activation motifs are essential for the membrane recruitment of SOS and Vav .
Output: ZAP - 70
The preference for third base codon in Y position prolines is U for the alpha 2 ( VI ) collagen as it is for the human fibrillar collagen genes .
Output: alpha 2
Intrathecal injections of small volumes of the alpha 2 - adrenoceptor agonists , xylazine and clonidine , into the cervical region of the spinal cord of conscious unrestrained sheep produced a dose - dependent analgesia of the forelimbs as measured using a mechanical pressure device .
Output: alpha 2
Cotransfection of a junB stimulated the basal activity of the alpha 2 ( I ) collagen promoter 93 - fold , respectively .
Output: alpha 2
Growth factors promote cell survival through phosphorylation of Bad , resulting in its dissociation from Bcl - 2 and Bcl - x ( L ) and its association with 14 - 3 - 3tau .
Output: Bcl - 2
Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13 . 3 , a region associated with the microphthalmia - cataract syndrome CATM and the alpha - thalassemia / mental retardation syndrome ATR - 16 .
Output: t complex
Sequence analysis of AEBP2 cDNA revealed that it encodes a protein containing three Gli - Kruppel ( Cys2 - His2 ) - type zinc fingers .
Output: AEBP2 cDNA
Antiserum raised against rat liver S6 kinase specifically immunoprecipitates the purified 32P - labeled H4 hepatoma insulin - stimulated S6 kinase .
Output: S6 kinase
Northern blot analysis confirmed that ADAMTS - 1 was up - regulated in both metaphyseal ( 14 - to 35 - fold ) and diaphyseal ( 4 . 2 - fold ) bone 1 h after PTH - ( 1 - 38 ) injection and returned to control levels by 24 h .
Output: ADAMTS - 1
The derepressed expression of fixN was not observed in a purH mutant .
Output: purH mutant
The library will thus be useful for the selection of cosmid clones which carry CDC genes from yeast by complementing first , with the vectorial yeast gene URA1 , the pyrimidine auxotrophy of most cdc - strains and then , with the respective CDC wild - type genes , of the temperature - sensitive mutant alleles .
Output: yeast gene URA1
The RsmA - mutant , like its parent , produces N - ( 3 - oxohexanoyl ) - L - homoserine lactone ( HSL ) , a starvation / cell density - sensing signal required for extracellular enzyme production .
Output: RsmA - mutant
The BRSV L gene is 6573 nt in length and the derived polypeptide has 2162 aa .
Output: BRSV L gene
Recombinant propeptides containing mutations of one of the three tryptophan residues were three orders of magnitude less effective as inhibitors of mature cathepsin S than the wild - type propeptide .
Output: mature cathepsin S
The human RIL gene : mapping to human chromosome 5q31 . 1 , genomic organization and alternative transcripts .
Output: RIL gene
A novel serine kinase activated by rac1 / CDC42Hs - dependent autophosphorylation is related to PAK65 and STE20 .
Output: serine kinase
The lipopolysaccharide - binding protein is a secretory class 1 acute - phase protein whose gene is transcriptionally activated by APRF / STAT / 3 and other cytokine - inducible nuclear proteins .
Output: STAT / 3
In situ hybridization reveals strong signals for Zep mRNA in the cerebellum and olfactory bulb with moderate signals detected in the hippocampus and cortex .
Output: Zep mRNA
To further investigate the role of PKR in transcriptional signaling , we expressed the wild type human PKR and a catalytically inactive dominant negative PKR mutant in the murine pre - B lymphoma 70Z / 3 cells .
Output: PKR mutant
All such polypeptides containing 263 or more residues derived from the C - terminus of P130gag - fps ( i . e . residues 920 - 1182 ) were enzymatically active as tyrosine kinases .
Output: tyrosine kinases
A child presumed to have the 21 - hydroxylase deficiency form of congenital adrenal hyperplasia was studied extensively as an infant .
Output: 21 - hydroxylase
Viral protein U ( Vpu ) is a protein encoded by human immunodeficiency virus type 1 ( HIV - 1 ) that promotes the degradation of the virus receptor , CD4 , and enhances the release of virus particles from cells .
Output: Viral protein U
Sucrose - specific signalling represses translation of the Arabidopsis ATB2 bZIP transcription factor gene .
Output: bZIP transcription factor
Mapping of the region in KAP - 1 required for HP1 interaction showed that amino acid substitutions which abolish HP1 binding in vitro reduce KAP - 1 mediated repression in vivo .
Output: KAP - 1
The activity of plasminogen activator has been measured in tissue sections with the aid of a modified Todd technique .
Output: plasminogen activator
The predicted amino acid sequence contained all consensus regions for S - adenosyl methionine methyltransferases and presented 26 % identity with Saccharomyces cerevisiae DHHB - methyltransferase and 38 % identity with the rat protein , as well as with a bacterial ( Escherichia coli and Salmonella typhimurium ) methyltransferase encoded by the UBIG gene .
Output: UBIG gene
Reduced risk of upper gastrointestinal ulcer complications with celecoxib , a novel COX - 2 inhibitor .
Output: COX - 2
Recently , we reported that SMRT also directly associates with LAZ3 ( BCL - 6 ) , a POZ / Zn finger transcriptional repressor involvedin the pathogenesis of non - Hodgkin lymphomas .
Output: BCL - 6
Immunological studies also failed to demonstrate any significant change except for a significant increase of natural killer ( NK ) cell activity after IFN - gamma infusion .
Output: IFN - gamma
Mycobacterium tuberculosis inhibits IFN - gamma transcriptional responses without inhibiting activation of STAT1 .
Output: IFN - gamma
Cloning of the GATA - binding protein that regulates endothelin - 1 gene expression in endothelial cells .
Output: endothelin - 1
Coronary vasoconstriction caused by endothelin - 1 is enhanced by ischemia - reperfusion and by norepinephrine present in concentrations typically observed after neonatal cardiopulmonary bypass .
Output: endothelin - 1
The first operon , orf1 - tolQRA , is iron regulated throughout growth , but iron - regulated expression of tolB and oprL fusions occurs only in late log phase .
Output: oprL fusions
Three distinct human HDACs are homologous to RPD3 , a yeast transcriptional regulator .
Output: human HDACs
The c - raf - 1 proto - oncogene is the cellular homologue of v - raf , the oncogene of the acutely transforming retrovirus 3611 - MSV .
Output: v - raf
A decrease was also found of the levels of total cholesterol and LDL - cholesterol .
Output: LDL - cholesterol
In contrast , vRel lacks a strong C - terminal gene activation function , since a LexA fusion protein containing C - terminal vRel sequences alone only weakly activated transcription .
Output: LexA fusion protein
These findings also demonstrate that unless excluded by other factors , the C proteins are likely to be located along the length of nascent transcripts .
Output: C proteins
The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide - induced bronchoconstriction in patients with asthma .
Output: leukotriene receptor
Transcription start sites of sal and salR genes were determined to lie 30 - and 24 - bp upstream of the respective initiation codons and separated from each other by 78 nucleotides .
Output: salR genes
ADR1 in extracts made from glucose - repressed and - derepressed cells bound UAS1 DNA with similar affinities despite having greatly different abilities to activate ADH2 gene expression in vivo .
Output: ADH2 gene
Scleraxis overexpression enhanced expression of the aggrecan gene , which is not normally expressed at high levels in these osteoblastic cells .
Output: aggrecan gene
Treatment of excessive bleeding after cardiopulmonary bypass was based on an algorithm using point - of - care testing with whole blood prothrombin time , activated partial thromboplastin time , heparinase activated clotting time , and platelet count .
Output: blood prothrombin
The generation of dorso - ventral polarity during Drosophila embryogenesis is regulated by the action of 12 maternally expressed gene products , the dorsal group .
Output: dorsal group
gp170 is expressed at a level 30 to 50 % of the Env precursor gp130 .
Output: Env precursor
The NF1 family members and HNF4 interacted with overlapping sequences of the L - II element , wherein the 5 ' half - site was more critical for NF1 binding , and the 3 ' site was more important for HNF4 binding .
Output: NF1 family
Siglec - 9 is predicted to contain three extracellular immunoglobulin - like domains that comprise an N - terminal V - set domain and two C2 - set domains , a transmembrane region and a cytoplasmic tail containing two putative tyrosine - based signaling motifs .
Output: Siglec - 9
Here , we analyzed the interaction of CYT - 18 with a small RNA ( P4 - P6 RNA ) corresponding to the isolated P4 - P6 domain of the N . crassa mitochondrial large subunit ribosomal RNA intron .
Output: CYT - 18
The gene encoding the Neisseria lactamica III DNA methyltransferase ( M . NlaIII ) which recognizes the sequence CATG has been cloned and expressed in Escherichia coli .
Output: M . NlaIII
Plasma insulin responses to glucose in femoral , hepatic , and pancreatic veins in dogs .
Output: Plasma insulin
TOM1 encodes a member of the hect - domain - containing E3 ubiquitin - protein ligase family that is required for growth at elevated temperatures .
Output: hect - domain
Site - directed mutagenesis of the conserved cysteine residue ( tom1C3235A ) in the hect - domain , supposed to be necessary for thioester - bond formation with ubiquitin , abolished the gene function .
Output: hect - domain
Multiple attempts aimed at disruption of the chromosomal fabG gene were unsuccessful .
Output: chromosomal fabG gene
Furthermore , the GC - rich sequences could confer Sp1 - dependent transactivation to a heterologous prolactin minimal promoter .
Output: prolactin minimal promoter
To address this question with respect to skeletal muscle , we have examined the effects of the Providence mutation in cultured muscle cells , after adoptive gene transfer to adult mice , and in two infants homozygous for spectrin Providence .
Output: spectrin Providence
A gene ( FMR - 1 ) was identified within a four cosmid contig of YAC DNA that expresses a 4 . 8 kb message in human brain .
Output: FMR - 1
When expressed in Escherichia coli , SH - PTP2 displays tyrosine - specific phosphatase activity .
Output: SH - PTP2
C . glabrata cells containing the CBF1 gene under the influence of a shutdown promoter ( tetO - ScHOP ) arrested their growth after 5 h of cultivation in the presence of the reactive drug doxycycline .
Output: CBF1 gene
GAGA factor is known to remodel the chromatin structure in concert with nucleosome - remodeling factor NURF in a Drosophila embryonic S150 extract .
Output: GAGA factor
Several of the drugs used in the management of MAC have been associated with significant drug interactions involving the cytochrome P450 ( CYP ) enzyme system .
Output: cytochrome P450
These include urinalysis , chest X - P , ECG , hematological examinations ( RBC , WBC , Ht , Hb , PLT and ESR ) and biochemical tests ( AST , ALT , ALP , gamma GTP , LDH , CPK , Chol , T - Bil , TP , Alb , TG , BUN , Cr , Glu , Na , K , Ca , P and CRP ) .
Output: gamma GTP
Transcriptional activation of the proopiomelanocortin gene by cyclic AMP - responsive element binding protein .
Output: proopiomelanocortin gene
Mutation of the HNF3 element significantly reduced promoter activity in HepG2 cells , whereas this element in isolation conferred HNF3beta responsiveness to a heterologous promoter .
Output: HNF3 element
It is hypothesized this occurs through antagonism of PML / RAR alpha actions in these leukemic cells .
Output: RAR alpha
Using the conflict drinking test as a model , we studied in rats the effect of the nonselective beta - adrenoceptor blockers pindolol and cyanopindolol which bind to 5 - HT1A and 5 - HT1B receptors , and of the selective beta 1 - and beta 2 - adrenoceptor antagonists betaxolol and ICI 118 , 551 , respectively , which have a negligible affinity for 5 - HT receptors .
Output: beta - adrenoceptor
It is an untested argument that conventional beta - adrenoceptor antagonists possess unwanted metabolic effects that may counter some of their potential cardiac benefits .
Output: beta - adrenoceptor
The 5 ' ends of the P and O gene mRNAs are separated by 109 nucleotide pairs in the DNA template .
Output: O gene mRNAs
Drosophila melanogaster casein kinase II ( DmCKII ) is composed of catalytic ( alpha ) and regulatory ( beta ) subunits associated as an alpha2beta2 heterotetramer .
Output: casein kinase II
We now describe a HepG2 cell casein kinase II beta subunit cDNA of 2 . 57 kb containing 96 bases of 5 ' untranslated sequence , 645 bases of open reading frame , and 1832 bases of 3 ' untranslated sequence with two polyadenylation consensus signal sequences and two poly ( A ) stretches .
Output: casein kinase II
A genomic clone of the chicken osteopontin - encoding gene ( opn ) was isolated and found to be organized as follows : an untranslated 5 ' exon ; a signal peptide ; a recognition sequence for phosphorylation by casein kinase II ; a domain containing a possible O - linkage site for glycosylation ; a second casein kinase II phosphorylation site ; an exon containing three functional regions , the poly - Asp sequence of seven consecutive Asp residues , the RGD integrin recognition site and a potential N - linkage site for glycosylation ; and a large C - terminal exon which also contains a potential N - linkage site for glycosylation .
Output: casein kinase II
Vertebrate U6 small nuclear RNA ( snRNA ) loci exemplify a novel class of polymerase III - transcribed genes that lack an intragenic control region ( ICR ) .
Output: polymerase III
A deletion analysis of the FAS1 promoter lacking the previously characterized inositol / choline - responsive - element motif defined a region ( nucleotides - 760 to - 850 ) responsible for most of the remaining activation potency .
Output: FAS1 promoter
Upstream tissue inhibitor of metalloproteinases - 1 ( TIMP - 1 ) element - 1 , a novel and essential regulatory DNA motif in the human TIMP - 1 gene promoter , directly interacts with a 30 - kDa nuclear protein .
Output: TIMP - 1
Hepatitis B immune globulins and HIV antibodies .
Output: HIV antibodies
These results demonstrate that GGTase - I inhibitors arrest cells in G0 / G1 and induce accumulation of p21WAF in a p53 - independent manner and that FTase inhibitors can interfere with cell cycle events by a mechanism that involves neither p21WAF nor p27KIP .
Output: GGTase - I
The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases , displays 34 - 42 % identically aligned amino acid residues with other cdc2 - related kinases , and is considerably longer at its amino and carboxyl termini .
Output: CHED protein
Translation of mok is tightly regulated by Sok RNA , and Sok RNA thus regulates hok translation indirectly through mok .
Output: Sok RNA
Cytokine inducibility of VCAM1 in endothelial cells utilizes the interaction of heterodimeric p50 / p65 proteins with IRF - 1 .
Output: IRF - 1
First , mutations in the IFNgamma - activated sequence ( GAS ) , either multimerized or in the context of the 1 . 7 - kb IRF - 1 promoter , failed to mediate a PRL response , showing that the IRF - 1 GAS is a target of PRL signaling .
Output: IRF - 1
However , ADAR1 and the related deaminase ADAR2 showed significant expression in all regions of the brain examined , including cortex , hippocampus , olfactory bulb , and striatum , where the 5 - HT2CR pre - mRNA was extensively edited .
Output: deaminase ADAR2
This C - terminal domain contains several YxxI / L motifs reminiscent of LMP2A and a putative TRAF binding site as in LMP1 .
Output: TRAF binding site
BACKGROUND : Recent iterative methods for sequence alignment have indicated that the 380 kDa motor unit of dynein belongs to the AAA class of chaperone - like ATPases .
Output: AAA class
Chromaffin cells transfected with a plasmid with the entire coding sequence of c - Rabphilin3a inserted in the antisense orientation inhibited secretion of co - expressed GH by approximately 30 % .
Output: c - Rabphilin3a
Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults .
Output: fumonisin B1
Four of these fibroblast clones were infected with a retrovirus containing the cDNA encoding myoD and a puromycin selection marker .
Output: cDNA encoding myoD
However , PC12 cell clones which expressed p33rsu - 1 at an increased level in a regulatable fashion in response to dexamethasone were isolated .
Output: p33rsu - 1
B and C1 fusions with yeast GAL4 DNA - binding and transcriptional activation domains were also found to interact when synthesized and assayed in yeast .
Output: C1 fusions
Using transgenic lines a detailed analysis of the Hoxa - 7 enhancer - directed expression during embryogenesis was performed .
Output: Hoxa - 7
A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase / thiamin - phosphate pyrophosphorylase involved in thiamin biosynthesis .
Output: hydroxymethylpyrimidine kinase
Induction of interferon - alpha ( IFNalpha ) gene expression in virus - infected cells requires phosphorylation - induced activation of the transcription factors IRF3 and IRF7 .
Output: interferon - alpha
Since 1985 the combination of chlorambucil ( 10 mg daily , initially for six weeks , then alternating fortnights for 12 weeks ) and interferon - alpha 2b ( Schering - Plough ; 2 x 10 ( 6 ) U / m2 three times weekly by subcutaneous injection for 18 weeks ) has been compared in a randomised trial with chlorambucil alone in previously untreated patients with stage III or IV follicular lymphoma .
Output: interferon - alpha
This paper describes a longitudinal study in which clinical parameters and aspartate aminotransferase ( AST ) in gingival crevicular fluid ( GCF ) were monitored bimonthly over a 6 - 12 months period in 970 sites from 7 treated periodontitis patients .
Output: aspartate aminotransferase
Thus , the mutants are deficient in production of the O - antigen polymerase and were termed rfc mutants .
Output: rfc mutants
Competition and methylation interference assays showed that the binding site for the novel factor was limited to nucleotides in the 3 ' half of the kappa B site .
Output: kappa B site
Tax was demonstrated to interact directly with CREB1 but not with other bZIP proteins , including CREB2 and Jun .
Output: bZIP proteins
Overexpression of eIF4E transforms cells , and mutations in eIF4E arrest cells in G , in cdc33 mutants .
Output: cdc33 mutants
Plasma enteroglucagon was measured before and during three hours after a standard meal in 21 untreated adult patients with suspected coeliac disease who all had villous atrophy of the small intestinal mucosa and malabsorption , and in nine control subjects .
Output: Plasma enteroglucagon
Members of the steroid / hormone nuclear receptor superfamily regulate target gene transcription via recognition and association with specific cis - acting sequences of DNA , called hormone response elements ( HREs ) .
Output: nuclear receptor superfamily
The human Fc gamma receptor gene Fc gamma RIIA is expressed in platelets , neutrophils , monocytes and macrophages .
Output: Fc gamma RIIA
We also show that the products of both the GIY - YIG ORF and the non - canonical LAGLI - DADG - GIY - YIG ORF , which is generated by its integration , have endonuclease activities which recognize and cut the insertion site of the optional sequence .
Output: GIY - YIG
Hetero - oligomerization of Smad4 with the pathway - restricted SMAD proteins is essential for Smad4 - mediated transcription .
Output: SMAD proteins
CRKL , an SH2 - SH3 - SH3 adapter protein , is one of the major tyrosine phosphoproteins detected in primary leukemic neutrophils from patients with CML .
Output: tyrosine phosphoproteins
Both flavoproteins are active as AhpC reductases and mediate electron transfer , resulting in the NADH - dependent reduction of hydrogen peroxide and cumene hydroperoxide .
Output: AhpC reductases
Developmental slot blots demonstrate that mRNAs corresponding to the three LHM cDNAs are transcribed from prophase of meiosis I to the uninucleate microspore stage , while Northern analysis reveals these tapetally expressed cDNAs to correspond with transcripts of some 500 bp .
Output: LHM cDNAs
PCC 6803 mutant impaired in cytochrome c maturation .
Output: cytochrome c
Studies on the reaction of cytochrome c with corticosteroids .
Output: cytochrome c
In the present study we use a tnaC - UGA - ' lacZ construct lacking the tnaC - tnaA spacer region to analyze the effect of TnaC synthesis on the behavior of the ribosome that translates tnaC .
Output: ' lacZ
This study demonstrates a novel link between alterations in platelet - derived growth factor ( PDGF ) regulation of ornithine decarboxylase ( ODC ) expression during malignant conversion .
Output: ornithine decarboxylase
( i ) p60 bound fast - migrating , underprocessed wild - type ICP22 and ICP22 lacking the carboxyl - terminal 24 amino acids but not ICP22 lacking the carboxyl - terminal 40 amino acids , whereas the previously identified cellular protein p78 ( R .
Output: cellular protein p78
Our results suggest a dose - dependent activity of lysine vasopressin on the EEG , which might be similar to that observed in animal and man after administration of nicotine .
Output: lysine vasopressin
By screening a human testis cDNA library with a probe containing the mouse PEA3 ETS domain , we isolated a 2 . 2 kb clone containing a 510 AA open reading frame .
Output: mouse PEA3
After inhibition of monoamine oxidase with pargyline ( 10 mg / kg . i . v . ) , the effects of tyramine ( 1000 micrograms ) injected into the hepatic artery were potentiated .
Output: monoamine oxidase
The inhibition of monoamine oxidase ( MAO ) by tranylcypromine was studied in 6 healthy volunteers given increasing doses of 10 , 15 , 20 and 25 mg / day over a 4 - week period .
Output: monoamine oxidase
Nitroglycerin ( glyceryl trinitrate ) as a monoamine oxidase inhibitor .
Output: monoamine oxidase
Toxicity of benzoyl chloride ( 2 , 4 , 6 - trichlorophenyl ) hydrazone ( Banamite ) and potential metabolites to twospotted spider mites and potency as inhibitors of rat liver monoamine oxidase .
Output: monoamine oxidase
This results in a decreased secretion of immunoglobulin A , and , consequently , a decreased resistance against infections .
Output: immunoglobulin A
The proteins encoded by these genes , called GF14 proteins , participate in protein / DNA complexes and show more than 60 % identity with a highly conserved , widely distributed protein family , collectively referred to as 14 - 3 - 3 proteins .
Output: GF14 proteins
Despite their high degree of sequence similarity , all five RFC genes are essential for cell proliferation in S . cerevisiae .
Output: RFC genes
Electrophoretic mobility - shift assays between viral RNA and BMV CP peptides with either proline or alanine substitutions revealed that the interaction is nonspecific .
Output: BMV CP peptides
The longest cDNA insert identified was 2 . 2 kb and encoded the entire 462 - amino acid open reading frame of rat CgA including an 18 - amino acid hydrophobic signal peptide .
Output: rat CgA
Primer extension analysis and subcloning of the virJ - phoA fusion indicate that the acetosyringone - inducible promoter lies directly upstream of the virJ structural gene .
Output: virJ structural gene
Patients in the mucinous cyst group had significantly lower CA 125 cystic fluid levels compared with women with endometriomas and dermoids ( P & lt ; 0 . 05 ) .
Output: CA 125
We report on a case of a 43 - old - male with a bronchogenic cyst in the distal esophagus , which was misdiagnosed as a malignant esophageal tumor based on preoperative imaging and high levels of the tumor markers CA 19 - 9 and CA 125 .
Output: CA 125
The enzyme ACC oxidase catalyses the last step of ethylene biosynthesis in plants , converting 1 - aminocyclopropane - 1 - carboxylic acid ( ACC ) to ethylene .
Output: enzyme ACC oxidase
Protein kinase C transiently activated heteromeric N - methyl - D - aspartate receptor channels independent of the phosphorylatable C - terminal splice domain and of consensus phosphorylation sites .
Output: Protein kinase C
Protein kinase C ( PKC ) activation after treatment of human neuroblastoma SK - N - BE ( 2 ) C cells with phorbol 12 - myristate 13 - acetate ( PMA ) was found to enhance transcription of the human dopamine beta - hydroxylase ( DBH ) in those cells .
Output: Protein kinase C
Highly significant similarities were detected between the N - terminal region of P30 and those of GENA [ the product of another unidentified gene ( geneA ) located upstream of the aceEF - lpd operon ] , and GNTR ( a putative transcriptional repressor of the gluconate operon of Bacillus subtilis ) .
Output: gluconate operon
Like the DMA , but unlike all other mammalian class II A genes , the zebrafish gene codes for two cysteine residues which might potentially be involved in the formation of a disulfide bond in the alpha 1 domain .
Output: alpha 1
Reactive mesothelial cells , usually seen as exfoliated cells , were consistently strongly positive for alpha 1 - antichymotrypsin and more variably for alpha 1 - antitrypsin and lysozyme .
Output: alpha 1
Following replicate control measurements , test ramps were repeated in the presence of sodium nitroprusside ( 1 microM ) and phentolamine ( 1 microM ) to eliminate potential smooth muscle and alpha 1 - adrenoceptor effects , respectively .
Output: alpha 1
The unusual properties of TRAC activity and its relationship , if any , with the enigmatic Ku protein , are discussed .
Output: Ku protein
The pattern of net RNA expression in adult mouse tissues is different .
Output: net RNA
The induction by dexamethasone of rat liver CYP3A1 differs from classical glucocorticoid gene regulation in part because both glucocorticoids and antiglucocorticoids such as pregnenolone 16 alpha - carbonitrile ( PCN ) induce CYP3A1 through transcriptional gene activation .
Output: rat liver CYP3A1
Human PDNP3 is expressed in glioma cells , prostate , and uterus , but not in the alimentary tract .
Output: Human PDNP3
The transcriptional start site , identified by primer extension and S1 nuclease assay , is 34 nt upstream of the translation initiation codon .
Output: S1 nuclease
S1 nuclease analysis of the RNA from a number of QT6 - LD clones gave similar results , indicating that the LD population was composed of viruses with similar but not identical deletion endpoints .
Output: S1 nuclease
S1 nuclease protection mapping and primer extension analysis allowed us to propose that the A residue located 19 bp upstream from the translation initiation codon is the site of transcription initiation .
Output: S1 nuclease
The strategy uses RNA ligase to add DNA oligonucleotide priming sites to the RNA for subsequent reverse transcription and PCR ( RNA ligase , reverse transcription - PCR , or RL / RT / PCR ) .
Output: RNA ligase
Plasma hemopexin homeostasis during the acute phase response .
Output: Plasma hemopexin
CONCLUSIONS : These results suggest that , by interacting with cellular transcription factors and cofactors , vIRF - 2 may modulate the expression of the early inflammatory genes and potentially deregulate the immune system .
Output: vIRF - 2
RESULTS : Although low levels of vIRF - 2 mRNAs can be detected in the HHV - 8 - positive BCBL - 1 tumor cell line , 12 - 0 - tetradecanoylphorbol - 13 - acetate ( TPA ) treatment does not stimulate expression of vIRF - 2 gene together with primary lytic cycle genes .
Output: vIRF - 2
These data suggested that mutant PS1 may cause disease as a result of reduction in PS1 function .
Output: mutant PS1
The deduced amino acid sequence of this open reading frame is significantly homologous to the HSV 1 UL49 . 5 gene product , and as with UL49 . 5 , it contains a potential signal sequence and transmembrane domain characteristic of membrane - associated proteins .
Output: UL49 . 5
The combination of ICP47 and US11 rendered fibroblasts negative for surface class I MHC and allowed a class I MHC - low population of T cells to be sorted by flow cytometry .
Output: class I MHC
Alterations in TCR - MHC contacts subsequent to cross - recognition of class I MHC and singly substituted peptide variants .
Output: class I MHC
Antisense oligonucleotides complementary to the 5 ' end of PKC - zeta mRNA sequences significantly reduced the collagen lattice - stimulated alpha2 and MMP - 1 mRNA levels .
Output: MMP - 1