niryuu/sni-each-converted huggingface dataset:
Introduction of Tax into resting Kit 225 cells induced activation of the G1 / S transition regulation cascade consisting of activation of cyclin dependent kinase 2 ( CDK2 ) and CDK4 , phosphorylation of the Rb family proteins and an increase in free E2F .
Output: Rb family proteins
MATERIALS AND METHODS : The cells were stimulated by 100 ng / mL TPO and / or 100 ng / mL TGF - beta1 and analyzed for proliferation ( 3H thymidine incorporation ) , viability ( trypan blue exclusion ) , and protein expression and phosphorylation ( Western blot ) .
Output: TGF - beta1
RESULTS : TPO enhanced the proliferation of Mo - 7e cells as determined by 3H - thymidine incorporation , whereas TGF - beta1 suppressed baseline cell growth and antagonized the proliferative effect of TPO .
Output: TGF - beta1
As demonstrated by Western blotting , TGF - beta1 reduced the TPO - stimulated ERK1 / ERK2 and STAT5 phosphorylation in Mo - 7e and HEL cells .
Output: TGF - beta1
This effect was completely reversed by preincubation with a tyrosine phosphatase inhibitor ( Na3VO4 ) , which suggests that TGF - beta1 activated a phosphatase .
Output: TGF - beta1
Although STAT3 also was activated by TPO , STAT3 activation remained unaltered by TGF - beta1 .
Output: TGF - beta1
CONCLUSION : Taken together , these data suggest that TGF - beta1 modulates TPO - mediated effects on megakaryocytic proliferation by interfering with TPO - induced signal transduction , particularly by reducing the activities of MAPK ERK1 / ERK2 and STAT5 .
Output: TGF - beta1
First , we found that TGF - beta1 significantly increases endogenous germ - line ( GL ) alpha transcripts by LPS - stimulated CH12 . LX . 4933 ( mu ( + ) ) B lymphoma cells .
Output: TGF - beta1
The results from the present study indicate that Smad3 , Smad4 , and Smad7 , at least in part , serve as mediators linking TGF - beta1 to transcriptional regulation of IgA switching related gene and regulation of IgA class switching .
Output: TGF - beta1
However , the larger native molecular mass of NF - P1 suggests that NF - P1 contains an additional non - DNA - binding subunit ( s ) .
Output: NF - P1
This complex appeared 10 to 25 minutes before the activation of the IL - 2 gene .
Output: IL - 2
L2 and L2 variant cells were tested for IL - 2 responsiveness and rapamycin sensitivity with respect to specific kinase activity , PCNA expression and proliferation .
Output: IL - 2
However , phosphorylation of CREB alone is not sufficient to drive PCNA expression and L2 cell proliferation in the absence of IL - 2 .
Output: IL - 2
However , there has been no direct demonstration that activator protein - 1 is involved in CD28 - dependent costimulation of IL - 2 gene transcription in freshly isolated naive and memory human T lymphocytes .
Output: IL - 2
T cells retained their physical parameters as measured by forward and side light scatter , and functional activity as measured by costimulation of proliferation and IL - 2 production after being scraped off this substrate .
Output: IL - 2
CD28 / CD3 - costimulated T cells produced intracellular IL - 2 from all subsets measured ( CD4 + , CD4 - , CD45RO + , and CD45RO - ) .
Output: IL - 2
IL - 2 production and intracellular accumulation in nonscraped PB - T cells activated with CD28 / CD3 coligation were skewed favoring CD45RO + and CD4 + subsets , as was IL - 2 production in scraped PB - T cells .
Output: IL - 2
However , IL - 2 production reached only suboptimal levels in the presence of CD86 but optimal levels with CD80 .
Output: IL - 2
CD80 induced higher levels of IL - 2 promoter - enhancer activity compared to CD86 .
Output: IL - 2
Our results suggest that the eventual appearance of CD80 on recently activated CD86 + APC is important for the superinduction of IL - 2 production and to support vigorous T cell proliferation .
Output: IL - 2
The constant expression of large numbers of IL - 2 receptors which may be aberrant may play a role in the uncontrolled growth of adult T - cell leukemia cells .
Output: IL - 2
Treatment of lymphocytes with cytochalasin D , which blocks actin polymerization , inhibited cap formation and produced defects in signaling and IL - 2 transcriptional induction in response to antigen - receptor signaling that were nearly identical to those seen in vav - / - cells .
Output: IL - 2
Furthermore , the correlation between cap formation , IL - 2 production and proliferation supports the hypothesis that an actin - dependent pathway is a source of specialized growth regulatory signals .
Output: IL - 2
Due to Jurkat T - cells being IL - 2 - independent , it was postulated that IL - 2 might provide a necessary co - stimulus for phosphorylation of CREB in primary lymphocytes .
Output: IL - 2
IL - 2 did not further augment phosphorylation of CREB following CD2 cross - linking .
Output: IL - 2
In contrast to previous studies performed in the absence of exogenous IL - 2 , no increase in binding of CREB to a 32P - labeled oligonucleotide probe was observed by electrophoretic mobility shift assay .
Output: IL - 2
These data suggest that the IL - 2 and CD3 signaling pathways provide a necessary and co - operative stimulus promoting phosphorylation of CREB following receptor cross - linking .
Output: IL - 2
In addition , the proliferative advantage of p12 ( I ) - transduced PBMCs was evident mainly at low concentrations of IL - 2 .
Output: IL - 2
Caspase - mediated calcineurin activation contributes to IL - 2 release during T cell activation .
Output: IL - 2
Calcineurin , a Ca ( 2 + ) / calmodulin - dependent Ser / Thr phosphatase ( protein phosphatase 2B ) , plays a critical role in IL - 2 production during T cell activation .
Output: IL - 2
It has been previously reported that IL - 2 release in activated Jurkat T requires caspase - like activity ( Posmantur et al . ( 1998 ) Exp . Cell . Res . 244 , 302 - 309 ) .
Output: IL - 2
Increase secretion of IL - 2 , the major T cell growth and differentiation cytokine , may play a decisive role in sensitization of T cells for activation induced apoptosis and indirect death of activated T cells through augmented virus replication .
Output: IL - 2
We demonstrate that increased IL - 2 secretion is due to Tat - enhanced IL - 2 promoter activation .
Output: IL - 2
Both CD4 + and CD8 + T cells that produce IL - 2 in response to Ag recognition have been isolated .
Output: IL - 2
However , most effector CD8 + T cells recovered after exposure to Ag do not produce sufficient IL - 2 to sustain growth , and depend on CD4 + T helper cells for this obligate growth factor .
Output: IL - 2
IL - 2 expression in CD4 + T cells is primarily controlled at the level of transcription , but mechanisms restricting IL - 2 production in CD8 + T cells have not been elucidated .
Output: IL - 2
This proliferative defect is not reversed by addition of exogenous IL - 2 and is p53 - independent .
Output: IL - 2
Furthermore , hematopoiesis in mice lacking Gadd45gamma is not impaired and Gadd45gamma - deficient T lymphocytes show normal responses to IL - 2 .
Output: IL - 2
Gadd45gamma is also dispensable for IL - 2 - induced T - cell proliferation .
Output: IL - 2
Signaling through the TCR and costimulatory signals primarily control transcription of the IL - 2 gene in naive T cells .
Output: IL - 2
The IL - 2 gene can be induced by the AHR also in thymocytes in vivo after injection of 2 , 3 , 7 , 8 - tetrachlorodibenzo - p - dioxin , a potent ligand of the AHR .
Output: IL - 2
The AHR mediates the IL - 2 induction as shown with AHR - deficient mice .
Output: IL - 2
However , in spleen cells in vitro costimulation via the TCR is necessary for optimal IL - 2 gene induction .
Output: IL - 2
In addition , Tax703 and Tax , but not TaxM22 , converted cell growth of a mouse T - cell line from being interleukin ( IL ) - 2 - dependent to being IL - 2 - independent .
Output: IL - 2
Under the same conditions , Lck did not stimulate IL - 2 promoter unless it was activated by mutation .
Output: IL - 2
Glucocorticoids inhibit signal transduction through IL - 2 receptor .
Output: IL - 2
Glucocorticoids inhibit IL - 2 production by inhibiting TCR - mediated signal transduction .
Output: IL - 2
Human peripheral blood T cells , stimulated with PMA for 48 h ( PMA blasts ) , were incubated with IL - 2 in the presence of incremental dosages of dexamethasone ( Dex ; 10 ( - 5 ) - 10 ( - 9 ) M ) .
Output: IL - 2
Dex inhibited the IL - 2 - dependent proliferation of PMA blasts in a dose - dependent fashion ( IC50 , 5 x 10 ( - 8 ) M ) .
Output: IL - 2
In addition , Scatchard plot analysis of 125I - labeled IL - 2 showed that Dex did not affect the binding of IL - 2 , thus suggesting that inhibition is due to a postreceptor effect .
Output: IL - 2
Hypoxia down - regulates MCP - 1 expression : implications for macrophage distribution in tumors .
Output: MCP - 1
Monocyte chemoattractant protein 1 ( MCP - 1 ) is likely to contribute to the macrophage infiltrate in human ovarian carcinomas .
Output: MCP - 1
Although MCP - 1 is predominantly expressed by the tumor parenchyma , macrophages accumulate at highest density in necrotic regions , which are associated with low oxygen tensions .
Output: MCP - 1
We have investigated the effect of hypoxia both on MCP - 1 expression in ovarian cancer cell lines and monocyte migration .
Output: MCP - 1
Monocyte migration in response to MCP - 1 was also diminished under hypoxic conditions .
Output: MCP - 1
Down - regulation of MCP - 1 expression and the inhibition of monocyte migration are independent effects of hypoxia that may contribute to the distribution of macrophages within ovarian tumors .
Output: MCP - 1
Peritoneal macrophages seem to participate in the process of peritoneal fibrosis and monocyte chemoattractant protein - 1 ( MCP - 1 ) plays a key role in the recruitment of monocytes toward the peritoneal cavity .
Output: MCP - 1
However , little is known about the effect of high glucose on MCP - 1 expression and its signal transduction pathway in human peritoneal mesothelial cells .
Output: MCP - 1
MCP - 1 expression of mRNA and protein was measured by Northern blot analysis and enzyme - linked immunosorbent assay ( ELISA ) .
Output: MCP - 1
RESULTS : Glucose induced MCP - 1 mRNA expression in a time - and dose - dependent manner .
Output: MCP - 1
MCP - 1 protein in cell culture supernant was also increased .
Output: MCP - 1
High - glucose - conditioned supernatant possessed an increased chemotactic activity for monocytes , which was neutralized by anti - MCP - 1 antibody .
Output: MCP - 1
Monocyte chemoattractant protein - 1 ( MCP - 1 ) is a potent chemokine that stimulates the migration of monocytes into the intima of the arterial wall .
Output: MCP - 1
The objective of the present study was to investigate the effect of homocysteine on MCP - 1 production in endothelial cells .
Output: MCP - 1
The secretion of MCP - 1 protein was significantly increased ( 195 % as compared to the control ) in cells treated with pathological concentrations of homocysteine .
Output: MCP - 1
Such effect was accompanied by an increased expression of MCP - 1 mRNA ( 176 % as compared to the control ) in endothelial cells which resulted in enhanced monocyte chemotaxis .
Output: MCP - 1
In conclusion , our results indicate that homocysteine stimulates MCP - 1 expression in endothelial cells leading to enhanced monocyte chemotaxis .
Output: MCP - 1
Proliferating lymphocytes and gamma - interferon thus increased the antimicrobial activity of phagocytes exposed to glucocorticoids over that of control cells .
Output: gamma - interferon
Macrophage activation and correction of the dexamethasone effect by gamma - interferon , however , was dependent on the pathogen .
Output: gamma - interferon
Suppression of macrophage antimicrobial activity should thus be considered when treating patients with glucocorticoids ; its prevention by gamma - interferon might be beneficial for some but not all pathogens .
Output: gamma - interferon
The FAIM sequence is highly evolu - tionarily conserved , suggesting an important role for this molecule throughout phylogeny .
Output: FAIM sequence
Catalytically active Syk promotes and stabilizes the formation of tightly capped BCR complexes at the plasma membrane .
Output: BCR complexes
Lyn is not required for the recruitment of Syk to the cross - linked receptor , but is required for the internalization of the clustered BCR complexes .
Output: BCR complexes
Rather , the small isoform assembled into multimeric complexes with DNA - bound Ikaros at the pericentromeric foci .
Output: multimeric complexes
A nonpeptidyl small molecule SB 247464 , capable of activating granulocyte - colony - stimulating factor ( G - CSF ) signal transduction pathways , was identified in a high - throughput assay in cultured cells .
Output: G - CSF
More than 90 % of patients with severe congenital neutropenia ( SCN ) respond to granulocyte colony - stimulating factor ( G - CSF ) therapy .
Output: G - CSF
The in vitro effect of G - CSF and corticosteroids on granulopoiesis was evaluated in clonogenic assays of marrow mononuclear cells , by proliferation studies of the murine myeloid cell line 32D expressing the patient ' s mutated G - CSFR , and by measuring STAT5 activation in nuclear extracts from stimulated cells .
Output: G - CSF
Clonogenic assays of the patient ' s marrow mononuclear cells incorporating either G - CSF or hydrocortisone produced little neutrophil growth .
Output: G - CSF
In contrast , inclusion of both G - CSF and hydrocortisone in the cytokine ` ` cocktail ' ' markedly increased the neutrophil numbers .
Output: G - CSF
When small daily doses of oral prednisone were then administered to the patient with conventional doses of subcutaneous G - CSF , the patient responded with increased neutrophil numbers and with a complete reversal of the infectious problems .
Output: G - CSF
These data provide insight into SCN unresponsive to standard G - CSF treatment and to the potential corrective action of combined treatment with G - CSF and corticosteroids through synergistic activation of STAT5 .
Output: G - CSF
BMS - 189453 , a novel retinoid receptor antagonist , is a potent testicular toxin .
Output: retinoid receptor
Here , we demonstrate that engineered down - regulation of HIF - 1alpha by intratumoral gene transfer of an antisense HIF - 1alpha plasmid leads to the down - regulation of VEGF , and decreased tumor microvessel density .
Output: HIF - 1alpha
Antisense HIF - 1alpha monotherapy resulted in the complete and permanent rejection of small ( 0 . 1 cm in diameter ) EL - 4 tumors , which is unusual for an anti - angiogenic agent where transient suppression of tumor growth is the norm .
Output: HIF - 1alpha
The association of trans - acting T cell factors ( TCFs ) or lymphoid enhancer factor 1 ( LEF - 1 ) with their coactivator beta - catenin mediates transient transcriptional responses to extracellular Wnt signals .
Output: LEF - 1
This rapid induction of adipophilin is accompanied by a significant increase of free fatty acids in monocytes incubated with E - LDL .
Output: E - LDL
As the role of p50 remains unclear , we focused our present study on NF - kappa B1 ( p50 / p105 ) gene regulation .
Output: p50 / p105
The MRP14 gene was not expressed in monoblastic ML - 1 cells , promonocytic U - 937 cells , or promyelocytic HL - 60 cells .
Output: MRP14 gene
Since the rise in E2 - receptor display paralleled a large increase in the proliferative activity of the cells as well as a change in their maturation status the question was raised as to whether the E2 - receptor should be considered as a physiological marker of growth rate or of cellular differentiation .
Output: E2 - receptor
This suggests the association of E2 - receptor expression with control of growth rather than cell maturation .
Output: E2 - receptor
Tax703 preferentially activated the kappaB element but not the CRE - like one , whereas TaxM22 showed the reverse .
Output: kappaB element
Here we demonstrate that the unique region of Gads contains a capase cleavage site .
Output: capase cleavage site
Indeed , in vivo primed T cells predominantly express p50 / p50 and p65 / p50 dimers , whereas these p50 - containing complexes are barely detectable in tolerant T cells that express p65 - and c - Rel - containing complexes .
Output: c - Rel
Stimulation of T lymphocytes results in a rapid increase in intracellular calcium concentration ( [ Ca2 + ] i ) that parallels the activation of Ca2 + - calmodulin - dependent protein kinase IV ( CaMKIV ) , a nuclear enzyme that can phosphorylate and activate the cyclic adenosine monophosphate ( cAMP ) response element - binding protein ( CREB ) .
Output: nuclear enzyme
We find that the alternatively spliced E12 and E47 bHLH proteins of the E2A gene play similar and additive roles in supporting B lymphopoiesis .
Output: E2A gene
To study B cell - specific changes that occur during the aging process , we investigated expression patterns of Pax - 5a and 5d in mature B cells of young and aged mice .
Output: Pax - 5a
No effect of LPS treatment was detected on p105 or p100 , which also retain rel family members in the cytoplasm .
Output: rel family members
Influence of sex hormone binding globulin and serum albumin on the conversion of androstenedione to testosterone by human erythrocytes .
Output: serum albumin
Translocation of antigenic peptides into the cytosol of antigen presenting cells facilitates proteosomal processing and loading into Class I molecules for MHC presentation on the cell surface .
Output: Class I molecules
We found that the conversion of 70Z / 3 pre - B lymphocytes to cells with a macrophage - like phenotype is associated with the loss of E2A and EBF .
Output: - B
Western blot analysis showed a 52 - kD BSAP band in B - cell lines , but not in non - B - cell or plasma cell lines .
Output: - B
Differential ultraviolet - B - induced immunomodulation in XPA , XPC , and CSB DNA repair - deficient mice .
Output: - B
DNA damage plays a crucial role in these immunomodulatory effects of ultraviolet B , as impaired repair of ultraviolet - B - induced DNA damage has been shown to cause suppression of cellular immunity .
Output: - B
Ultraviolet - B - induced DNA damage is repaired by the nucleotide excision repair mechanism very efficiently .
Output: - B
These data suggest that both global genome repair and transcription - coupled repair are needed to prevent immunomodulation by ultraviolet B , whereas transcription - coupled repair is the major DNA repair subpathway of nucleotide excision repair that prevents the acute ultraviolet - B - induced effects such as erythema .
Output: - B
Pax5 - deficient pro - B cells are , however , not yet committed to the B - lymphoid lineage , but instead have a broad lymphomyeloid developmental potential .
Output: - B
Pax5 appears to mediate B - lineage commitment by repressing the transcription of non - B - lymphoid genes and by simultaneously activating the expression of B - lineage - specific genes .
Output: - B
The multilineage progenitor ( MLP ) assay enabled us to discriminate among seven types of hematopoietic progenitors , which are multipotent progenitor p - MTB ( capable of generating myeloid , T and B cells ) , bipotent progenitors p - MT , p - MB and p - TB , and unipotent progenitors p - M , p - T and p - B .
Output: - B
EBV - specific CTL were then generated in vitro by stimulating PBL with autologous EBV - transformed B cells ( EBV - B ) in the presence or absence of autologous BMC .
Output: - B
Inhibition was even observed by preparing EBV - CTL generating cultures in trans - wells that separated the autologous BMC from the PBL + EBV - B .
Output: - B
Retinoic acid up - regulates myeloid ICAM - 3 expression and function in a cell - specific fashion - - evidence for retinoid signaling pathways in the mast cell lineage .
Output: ICAM - 3
Investigation of mast cell responsiveness toward retinoic acid ( RA ) revealed selective promotion of ICAM - 3 expression in the human mast cell line HMC - 1 .
Output: ICAM - 3
ICAM - 3 modulation was found to be cell - type dependent , detectable also for HL - 60 cells and monocytes but not U - 937 and only weakly for KU812 cells .
Output: ICAM - 3
Terminally differentiated skin mast cells also failed to up - modulate their ICAM - 3 , suggesting the requirement for some degree of immaturity for the process .
Output: ICAM - 3
Thus , unlike Old World primates , cortisol in New World primates has only weak sodium - retaining potency because the aldosterone receptor has a low affinity for cortisol .
Output: aldosterone receptor
We analyzed the 5 ' transcription control sequences of the human CD4 gene .
Output: human CD4 gene
Altered interaction between triiodothyronine and its nuclear receptors in absence of cortisol : a proposed mechanism for increased thyrotropin secretion in corticosteroid deficiency states .
Output: nuclear receptors
Therefore , a possible role of cortisol in interaction between triiodothyronine and its nuclear receptors was examined at the level of circulating lymphocytes obtained from patients with primary or secondary adrenocortical failure .
Output: nuclear receptors
The peroxisome proliferator - activated receptors ( PPARs ) alpha and gamma are nuclear receptors that play important roles in inflammatory diseases like ulcerative colitis and arthritis .
Output: nuclear receptors
The ATRA metabolites were found to exert their differentiation effects via the RAR alpha nuclear receptors , because the RAR alpha - specific antagonist BMS614 blocked metabolite - induced CD11c expression in NB4 cells .
Output: nuclear receptors
[ Tumor histology and steroid receptors in breast carcinoma ]
Output: steroid receptors
Correlation of steroid receptors with histologic differentiation in mammary carcinoma .
Output: steroid receptors
Cellularity and fibrosis were unrelated to the presence or absence of oestrogen receptor .
Output: oestrogen receptor
The regulation of GM - CSF expression is seen in both normal human mitogen - activated T lymphocytes and T lymphocytes from a line ( S - LB1 ) transformed with human T cell lymphotropic virus 1 ( HTLV - 1 ) .
Output: GM - CSF
Retinoic acid ( RA ) inhibited 3H - thymidine incorporation in response to GM - CSF .
Output: GM - CSF
Expression of the granulocyte - macrophage colony - stimulating factor ( GM - CSF ) gene in T cells is activated by the combination of phorbol ester ( phorbol myristate acetate ) and calcium ionophore ( A23187 ) , which mimic antigen stimulation through the T - cell receptor .
Output: GM - CSF
Stimulation probably was mediated by CLE0 - binding proteins because depletion of these proteins specifically reduced GM - CSF transcription .
Output: GM - CSF
The characteristics of these two factors are consistent with their involvement in GM - CSF induction .
Output: GM - CSF
Whereas expression of E2A mRNA and protein are unaltered , Id3 transcripts are rapidly induced upon signaling from the TCR .
Output: Id3 transcripts
The discordant mutants may reflect interactions with a variable domain of a conserved component or unique interactions with specialized components of the basal transcription apparatus in different cells .
Output: variable domain
The conclusions from these findings are : ( a ) the inhibition of mitogenic stimulation by 1 , 25 ( OH ) 2D3 is mediated by specific functional receptors to the hormone ; and ( b ) the receptors for 1 , 25 ( OH ) 2D3 in mononuclear cells are probably controlled genetically by the same mechanisms as the effector system in well - characterized target organs of the hormone , such as intestine and kidney .
Output: specific functional receptors
The ZEBRA protein activates expression of Epstein - Barr virus early - lytic - cycle genes in human B lymphocytes .
Output: ZEBRA protein
Transcription factors that regulate monocyte / macrophage differentiation .
Output: Transcription factors
Transcription factors are essential to govern differentiation along the lymphoid lineage from uncommitted hematopoietic stem cells .
Output: Transcription factors
Neither full - length isoform alters growth of a myeloid cell line under nondifferentiating conditions , but the proximal isoform selectively delays mitotic arrest of the cell line under differentiating conditions , resulting in the generation of greater numbers of neutrophils .
Output: proximal isoform
In addition , eosinophils were found to constitutively express NFATc mRNA .
Output: NFATc mRNA
The relative volume of the tubulointerstitium was measured by an image analyzer ; deposition of collagen types III and IV and monocyte / macrophage infiltration were histologically examined using specific antibodies .
Output: specific antibodies
Leukocyte - endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF - kB - dependent fashion .
Output: NF - kB
Electrophoretic mobility shift assay of nuclear extracts of human umbilical vein endothelial cells ( HUVEC ) exposed for 1 h to 30 mM glucose revealed an intense NF - kB activation .
Output: NF - kB
Treatment of HUVEC exposed to high glucose with the NF - kB inhibitors pyrrolidinedithiocar ( 100 microM ) and tosyl - phe - chloromethylketone ( 25 microM ) significantly reduced ( P < 0 . 05 ) leukocyte adhesion in respect to HUVEC treated with glucose alone .
Output: NF - kB
These data indicate that high glucose concentration and hyperglycemia promote leukocyte adhesion to the endothelium through upregulation of cell surface expression of adhesive proteins , possibly depending on NF - kB activation .
Output: NF - kB
At 1 . 25 micromol / L , sulfasalazine largely inhibited NF - kB activation in dendritic cells .
Output: NF - kB
Genes encoding CBFbeta ( CBFB ) , and one of the DNA - binding CBFalpha subunits , Runx1 ( also known as CBFalpha2 , AML1 , and PEBP2alphaB ) , are required for normal hematopoiesis and are also frequent targets of chromosomal translocations in acute leukemias in humans .
Output: Genes encoding CBFbeta
Expression of activated Raf oncoproteins also abrogated cytokine dependency and prevented apoptosis of TF - 1 cells .
Output: Raf oncoproteins
Deregulation of bcl - 6 expression by chromosomal rearrangements and point mutations of the bcl - 6 promoter region are implicated in the pathogenesis of B - cell lymphoma .
Output: bcl - 6
The signals regulating bcl - 6 expression are not known .
Output: bcl - 6
The translesion DNA polymerase zeta plays a major role in Ig and bcl - 6 somatic hypermutation .
Output: bcl - 6
Identification of the precise mechanism by which activated GR recruits HDAC2 may reveal new targets for the development of drugs that may dissociate the antiinflammatory actions of glucocorticoids from their side effects that are largely due to gene induction .
Output: activated GR
Our findings dismiss the concept that the different immunoglobulin expression in cHD and LPHD is due to disrupting mutations of immunoglobulin V genes in cHD but is most likely due to a down - regulation of Oct2 and / or BOB . 1 / OBF . 1 .
Output: immunoglobulin V genes
` ` Footprint ' ' and methylation - interference analyses have shown that purified NF - kappa B has a binding activity specific for the kappa light chain enhancer sequence .
Output: kappa light chain
Moreover , we show that ectopic expression of the E2A protein E12 in this macrophage line results in the induction of many B lineage genes , including EBF , IL7Ralpha , lambda5 , and Rag - 1 , and the ability to induce kappa light chain in response to mitogen .
Output: kappa light chain
The senile plaques of Alzheimer ' s disease are foci of local inflammatory responses , as evidenced by the presence of acute phase proteins and oxidative damage .
Output: acute phase proteins
The activation of resting T cells for the acquisition of various functions depends on whether CD28 costimulatory signals are provided upon T cell receptor stimulation .
Output: T cell receptor
Caspase - dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor .
Output: T cell receptor
We show here that E2A DNA binding is lowered in primary immature thymocytes consequent to T cell receptor ( TCR ) - mediated ligation .
Output: T cell receptor
Paraffin - embedded tissues from 23 cutaneous lesions and a single lymph node biopsy from patients diagnosed with MF were evaluated for p65 ( Rel A ) expression by using a monoclonal mouse antibody that detects the activated form of p65 ( Rel A ) .
Output: monoclonal mouse antibody
Identification of a novel lymphoid specific octamer binding protein ( OTF - 2B ) by proteolytic clipping bandshift assay ( PCBA ) .
Output: OTF - 2B
Here we present evidence for yet another B cell specific octamer binding protein of 75 kd ( OTF - 2B ) .
Output: OTF - 2B
The mutation pattern was similar to that of Ig genes .
Output: Ig genes
Inhibition of the ubiquitin - proteasome pathway in B cells leads to elevated levels of OBF - 1 protein .
Output: OBF - 1
Furthermore , in immunized mice , OBF - 1 protein amounts are dramatically increased in primary activated B cells , without concomitant increase in OBF - 1 mRNA .
Output: OBF - 1
Regulation of cellular retinoic acid binding protein ( CRABP II ) during human monocyte differentiation in vitro .
Output: CRABP II
By representative difference analysis we found that CRABP II is also strongly expressed in human monocyte - derived macrophages ( MAC ) but not in freshly isolated monocytes ( MO ) .
Output: CRABP II
Adherence , which is important for MO differentiation , induced CRABP II expression , but the addition of 10 ( - 7 ) M retinoic acid inhibited the upregulation of CRABP II expression during MO / MAC differentiation .
Output: CRABP II
In contrast to MAC , MO - derived dendritic cells showed an extremely low expression of CRABP II .
Output: CRABP II
VP16 Ag - specific DQ - restricted T cells were identified and expanded from the peripheral blood of HSV - 2 - infected individuals , representing two predominant epitope specificities .
Output: VP16 Ag
However , OTF interaction with the heptamer sequence appeared to require the presence of an intact octamer motif and occurred with a spacing of either 2 or 14 base pairs between the two elements , suggesting coordinate binding resulting from protein - protein interactions .
Output: heptamer sequence
fNF - E2 mRNA was found to be more abundant in erythroid cells than megakaryocytic cells at day 7 of culture .
Output: fNF - E2
Although both isomers were expressed in human erythroid - megakaryocytic cell lines , megakaryocytic maturation with loss of erythroid phenotype induced by phorbol 12 - myristate 13 - acetate ( PMA ) resulted in exclusive downregulation of fNF - E2 , suggesting that fNF - E2 promoter is more erythroid specific .
Output: fNF - E2
The steroid receptor content does not correlate with histological parameters
Output: steroid receptor
Analysis has shown a relative interdependence between the steroid receptor status of primary breast cancer and other prognostic variables such as histological grade , lymphocytic infiltration and tumour elastosis .
Output: steroid receptor
Evidence for a steroid receptor in rheumatoid synovial tissue cells .
Output: steroid receptor
This was followed by apparent apoptosis , and both processes were specifically inhibited by the gp34 - specific neutralizing monoclonal antibody 5A8 .
Output: monoclonal antibody
Activated STAT3 was shown to bind an SIE - related element in the murine mcl - 1 promoter .
Output: Activated STAT3
Similar to other TNF family members , BLyS is present in solution as a homotrimer as determined by gel filtration chromatography and light scattering analysis .
Output: TNF family members
BLyS binding to B cells is specific as other TNF family members tested did not compete for ( 125 ) I - BLyS binding .
Output: TNF family members
Mutant frequencies were measured in the spleen lymphocyte hprt gene , and lacI mutant frequencies were determined in the liver and spleen lymphocytes .
Output: hprt gene
A signaling complex of Ca2 + - calmodulin - dependent protein kinase IV and protein phosphatase 2A [ see comments ]
Output: protein phosphatase 2A
The PML protein is induced by interferon , involved in major histocompatibility complex class I presentation , and necessary for certain types of apoptosis .
Output: PML protein
The functional effects of these interactions are that CBP and p300 , but not P / CAF , enhance EKLF ' s transcriptional activation of the beta - globin promoter in erythroid cells .
Output: P / CAF
These findings present major differences in the early cell activation process between LPS and muramyl peptides , and strongly argue for the implication of co - receptors other than TLR2 and TLR4 in mediating the signaling events induced by defined subunits of bacterial peptidoglycans .
Output: co - receptors
During the early stages of chicken embryogenesis ( well before blood island formation ) , each of the GATA family members is transcribed with a unique temporal and spatial pattern .
Output: GATA family members