niryuu/sni-each-converted huggingface dataset:
She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.	 insulin
Output: 4 times per day
A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.	 brimonidine
Output: 1 drop
The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).	 TCA
Output: 200 mg
Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.	 ibuprofen
Output: overdose
Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.	 Ibuprofen
Output: overdose
In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.	 methotrexate
Output: low
A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.	 colchicine
Output: regular
The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.	 Miacalcic
Output: 25 UI
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.	 cytosine arabinoside
Output: high
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).	 ARA-C
Output: high
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).	 cytosine arabinoside
Output: high
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.	 clomipramine
Output: 150 mg/d
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.	 clozapine
Output: 150 mg/d
We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.	 meloxicam
Output: 15 mg
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.	 lansoprazole
Output: standard
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.	 omeprazole
Output: standard
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.	 pantoprazole
Output: standard
We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.	 adenosine
Output: 12 mg
After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.	 methylprednisolone
Output: 40 mg
Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.	 CBZ
Output: OD
Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.	 CBZ
Output: OD
We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).	 taxol
Output: 80 mg/m(2)x3
Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.	 IFN-alpha
Output: low
A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.	 sodium aurothiomalate
Output: 100 mg
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.	 LTG
Output: overdose
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.	 lamotrigine
Output: overdose
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.	 LTG
Output: overdose
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.	 valproic acid
Output: overdose
METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.	 VPA
Output: overdose
We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.	 vincristine
Output: 2 mg
A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.	 benztropine
Output: abuse
CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.	 metoclopramide
Output: conventional
CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.	 sertraline
Output: conventional
CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.	 venlafaxine
Output: conventional
He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).	 lansoprazole
Output: 60 mg twice daily
We describe a patient who developed HUS after treatment with mitomycin C (total dose 144 mg/m2) due to a carcinoma of the ascending colon.	 mitomycin C
Output: 144 mg/m2
A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.	 rosiglitazone
Output: 4 mg twice/day
We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.	 lidocaine
Output: overdose
CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.	 vasopressin
Output: low
The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.	 ticlopidine
Output: 500 mg
CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.	 amiodarone HCl
Output: 200 mg/day
Successful desensitization to high-dose methotrexate after systemic anaphylaxis.	 methotrexate
Output: high
While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously.	 prednisolone
Output: 40 mg/day
This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method.	 clonazepam
Output: 0.02 mg/kg/day
This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure.	 vecuronium
Output: high doses
We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.	 bleomycin
Output: 100 U
We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	 CBZ
Output: low or moderate dosage
We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	 clozapine
Output: low or moderate dosage
We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.	 lithium
Output: low or moderate dosage
A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.	 L-dopa
Output: 400 mg/day
We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.	 glyburide
Output: 900 mg
After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.	 vitamin D3
Output: 20 micro g/g
DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.	 ciprofloxacin
Output: 250 mg bid
However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).	 colchicine
Output: high
We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.	 pilocarpine
Output: overdose
In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.	 nimodipine
Output: overdosage
Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.	 Tiagabine
Output: overdose
Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).	 CAP-XRT
Output: 1600 mg/m2
Patient B developed perioral and upper extremity paresthesias during the fourth cycle of CAP alone (2500 mg/m2).	 CAP
Output: 2500 mg/m2
In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.	 quetiapine
Output: overdose
We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.	 quetiapine
Output: overdose
Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.	 flupirtine
Output: overdose
The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.	 carbamazepine
Output: 400 mg/day
A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.	 quetiapine
Output: higher doses
A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.	 cerivastatin
Output: 0.15 mg/day
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.	 Carboplatin
Output: low-dose
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.	 carboplatin
Output: low-dose
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.	 paclitaxel
Output: low-dose
We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.	 fluoxetine
Output: massive
The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.	 iron sucrose
Output: 16 mg/kg
Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.	 busulfan
Output: high-dose
Fatal radiation myelopathy after high-dose busulfan and melphalan chemotherapy and radiotherapy for Ewing's sarcoma: a review of the literature and implications for practice.	 melphalan
Output: high-dose
Inadvertent and accidental epinephrine overdose might result in potentially lethal complications.	 epinephrine
Output: overdose
Prominent positive U waves appearing with high-dose intravenous phenylephrine.	 phenylephrine
Output: high-dose
A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.	 venlafaxine
Output: 75 mg/day
High-dose methotrexate-associated acute renal failure may be an avoidable complication.	 methotrexate
Output: High-dose
A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.	 cloxacillin
Output: 500 mg
Myocardial ischemia associated with high-dose carmustine infusion.	 carmustine
Output: high-dose
Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.	 methylprednisolone
Output: high-dose
We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.	 glucocorticoids
Output: high-dose
We present the case of a 58-year-old woman who ingested more than 35 g of caffeine in a suicide attempt.	 caffeine
Output: 35 g
Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.	 Flecainide
Output: overdose
Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.	 flecainide
Output: overdose
The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia.	 acetylsalicylic acid
Output: low-dose
Hyponatraemia during low-dose carbamazepine therapy.	 carbamazepine
Output: low-dose
The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.	 olanzapine
Output: 20-mg daily
She had been on Copaxone 20 mg/day treatment for 2 years when she first exhibited gastrointestinal symptoms.	 Copaxone
Output: 20 mg/day
Multiple seizures after bupropion overdose in a small child.	 bupropion
Output: overdose
The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.	 bupropion
Output: 48 mg/kg
CASE SUMMARY: An 80-year-old white female, followed up at the Memory Clinic for mild cognitive impairment, had been taking propafenone 900 mg/d for >10 years for paroxysmal atrial fibrillation without adverse effects.	 propafenone
Output: 900 mg/d
Hemorrhage from a falx meningioma after internal use of low-dose aspirin.	 aspirin
Output: low-dose
We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.	 aspirin
Output: low-dose
CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.	 methylprednisolone
Output: high-dose
High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.	 methylprednisolone
Output: High-dose
Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.	 methotrexate
Output: high-dose
We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.	 dexmedetomidine
Output: 5.0 microg/kg
We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.	 glycopyrrolate
Output: 5.0 microg/kg
Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.	 bevacizumab
Output: 1.25 mg in 0.1 ml
One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.	 adalimumab
Output: 160 mg
Hepatotoxicity after high-dose methylprednisolone for demyelinating disease.	 methylprednisolone
Output: high-dose
We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.	 methylprednisolone
Output: high-dose
CONCLUSIONS: We present a case of a patient with CML who developed KS 12 months after starting treatment with imatinib 400 mg/d.	 imatinib
Output: 400 mg/d
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia.	 cytosine arabinoside
Output: high-dose
Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).	 lacosamide
Output: 600 mg/day
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.	 glipizide
Output: 10 mg
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.	 SMX
Output: 10 mg
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.	 sulfamethoxazole
Output: 10 mg
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.	 TMP
Output: 10 mg
An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.	 trimethoprim
Output: 10 mg
A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.	 ifosfamide
Output: 5 g/m2
Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.	 ifosfamide
Output: high dose
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.	 cytosine arabinoside
Output: high-dose
Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.	 cytosine arabinoside
Output: high-dose
We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.	 cytosine arabinoside
Output: high-dose
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.	 cyclophosphamide
Output: low dose
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.	 indomethacin
Output: low dose
We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.	 cyclophosphamide
Output: low dose
We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.	 indomethacin
Output: low dose
Two cases of lepromatous leprosy with erythema nodosum leprosum who were on high doses of clofazimine, showed discoloration of nail plate, subungual hyperkeratosis and onycholysis.	 clofazimine
Output: high doses
Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.	 Ara-C
Output: 100 mg/m2/d
Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.	 cytosine arabinoside
Output: 100 mg/m2/d
Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.	 isotretinoin
Output: 1 mg/kg/day
The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.	 chloral hydrate
Output: overdosage
A case of severe visual loss following a single dose of vincristine is described.	 vincristine
Output: single dose
Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.	 vincristine
Output: single dose
Visual loss after a single small dose of vincristine has never been reported.	 vincristine
Output: single small dose
Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.	 doxycycline
Output: 1 g
After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.	 cyclosporine A
Output: low-dose
A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).	 propylthiouracil
Output: 100 mg orally, three times a day
A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.	 D-penicillamine
Output: 1,200 g
Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.	 phenytoin
Output: 1 g
She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.	 carbamazepine
Output: 200 mg
She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.	 phenytoin sodium
Output: 300 mg/day
After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.	 amiodarone
Output: 2300 mg in 3 days
The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.	 methimazole
Output: 20 mg
A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.	 propranolol
Output: overdose
Esophageal spasm following propranolol overdose relieved by glucagon.	 propranolol
Output: overdose
A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.	 lithium
Output: high doses
A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.	 trazodone
Output: high doses
Two other patients who did not receive prochlorperazine, developed retinal problems which later improved, one after only 15 g of desferrioxamine.	 desferrioxamine
Output: 15 g
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).	 Intralipid
Output: 20%
Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.	 aspirin
Output: high-dose
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.	 cytarabine
Output: 300 mg
Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.	 tamoxifen
Output: high-dose
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.	 lorcainide
Output: 200 mg
In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.	 amiodarone
Output: low-dosage
Interstitial pneumopathy and low-dosage amiodarone.	 amiodarone
Output: low-dosage
Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.	 propranolol
Output: 80 mg
Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.	 CCNU
Output: high doses
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.	 fluoresone
Output: 750 mg
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.	 phenobarbital
Output: 750 mg
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.	 phenytoin
Output: 750 mg
Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.	 quinacrine hydrochloride
Output: 100 mg
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.	 ergonovine
Output: 0.05 mg
Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.	 disopyramide
Output: 300 to 600 mg/day
He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.	 digoxin
Output: 0.25 mg
Inappropriate antidiuretic hormone secretion after high dose vinblastine.	 vinblastine
Output: high dose
We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.	 vinblastine
Output: high dose
Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.	 chlorambucil
Output: high-dose
A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).	 procainamide
Output: 750 mg/day
A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).	 methotrexate
Output: 40 mg/m2
A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).	 MTX
Output: 40 mg/m2
Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.	 methotrexate
Output: low dose
We report the case of a 20-year-old female with polyarteritis nodosa (PAN) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac.	 ketoralac
Output: 30 mg
A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.	 acyclovir
Output: 30 mg/kg per day
We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.	 mefloquine
Output: 1,500 mg over two days
High-dose intravenous mannitol infusion in various clinical settings may result in acute renal failure (ARF).	 mannitol
Output: High-dose
This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.	 mannitol
Output: high-dose
Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.	 methotrexate
Output: high-dose
This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.	 HD-MTX
Output: 8 gm/m2 by 6 h continuous infusion
Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.	 methotrexate
Output: high-dose
We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.	 metronidazole
Output: 21 g over 14 days
Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.	 ibopamine
Output: 100 mg
A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.	 bromocriptine
Output: low-dose
Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.	 methotrexate
Output: low-dose
In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.	 methotrexate
Output: low-dose
An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.	 Levemepromazine
Output: high dose
An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.	 methotrimeprazine meleate
Output: high dose
The association of phenothiazine overdose and respiratory distress syndrome merits consideration.	 phenothiazine
Output: overdose
She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.	 morphine
Output: 450-mg
A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.	 cotrimoxazole
Output: high
Severe abdominal pain in low dosage clofazimine.	 clofazimine
Output: low
Amphotericin B overdose in pediatric patients with associated cardiac arrest.	 Amphotericin B
Output: overdose
CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.	 Amphotericin B
Output: overdose
Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.	 amphotericin B
Output: overdoses
INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.	 amphotericin B
Output: between 4.6 and 40.8 mg/kg/d
OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.	 amphotericin B
Output: overdose
METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.	 acyclovir
Output: overdose
We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period.	 methotrexate
Output: low
We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.	 prednisolone
Output: 25 mg/day
Acute dystonic reaction with low-dose pimozide.	 pimozide
Output: low
How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.	 gold
Output: low
We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.	 phenol-glycerine
Output: 0.3 ml
The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy.	 azathioprine
Output: 1 mg/kg
The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.	 Halfan
Output: higher
The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.	 mefloquine
Output: higher
FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.	 fluticasone propionate
Output: high
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.	 fluticasone propionate
Output: high
INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.	 fluticasone propionate
Output: high
METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).	 fluticasone propionate
Output: high
Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.	 metripranolol
Output: 0.6
This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.	 acyclovir
Output: 10 mg/kg
This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.	 lithium
Output: 10 mg/kg
We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.	 dapsone
Output: low
A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.	 minocycline
Output: 50 mg twice daily
Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.	 magnesium
Output: Overdose
Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.	 magnesium sulfate
Output: Overdose
We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.	 AZ
Output: excessive
On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.	 danazol
Output: 600 mg
We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.	 d-penicillamine
Output: 125-500 mg daily
Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.	 heroin
Output: overdose
Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.	 heroin
Output: overdose
We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.	 penicillin
Output: high
In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.	 desmethylsertraline
Output: 25 mg
In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.	 lamotrigine
Output: 25 mg
We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.	 5-aminosalicylic acid
Output: 3.0 g/day
We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.	 Pentasa
Output: 3.0 g/day
1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).	 alprazolam
Output: low
We report on three patients with acute schizophrenia, who developed severe akathisia during treatment with olanzapine (20-25 mg/d).	 olanzapine
Output: 20-25 mg/d
A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).	 isosorbide dinitrate
Output: 5 mg
In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.	 isosorbide dinitrate
Output: 5 mg
High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.	 phosphate
Output: High