niryuu/sni-each-converted huggingface dataset:
NS - 718 , a lipid nanosphere incorporating amphotericin B , is effective against pathogenic fungi and has low toxicity .
Output: toxicity
We compared the toxicity of NS - 718 with that of Fungizone ( amphotericin B - sodium deoxycholate ; D - AmB ) in vitro using renal cell cultures and in vivo by biochemical analysis , histopathological study of the kidney and pharmacokinetic study of amphotericin B following intravenous infusion of the formulation in rats .
Output: toxicity
Catalepsy was evaluated at the beginning and the end of the treatments .
Output: Catalepsy
Six ( 12 % ) and 4 ( 8 % ) patients experienced grade 2 hand - foot syndrome and stomatitis , respectively ( no episodes of grade 3 ) .
Output: stomatitis
Although several new anticoagulant drugs are in development , heparin remains the anticoagulant of choice to treat acute thrombotic episodes .
Output: thrombotic
In two of them , the MPO - ANCA titres transiently increased to 12 . 8 and 15 . 0 U / ml , respectively , despite continued PTU therapy , but no vasculitic disorders developed .
Output: vasculitic disorders
Toleration of high doses of angiotensin - converting enzyme inhibitors in patients with chronic heart failure : results from the ATLAS trial .
Output: heart failure
dl - Sotalol preferentially prolonged action potential duration ( APD ) in M cells dose - dependently ( 1 to 100 micromol / L ) , leading to QT prolongation and an increase in TDR .
Output: QT prolongation
Cocaine , ethanol , and cocaethylene cardiotoxity in an animal model of cocaine and ethanol abuse .
Output: cardiotoxity
The positive skin tests are in favour of immunological reactions and may help in diagnosis of allergy in the patients .
Output: allergy
Thus , two control groups were generated : group C1 , which included age - and sex - comparable lithium - treated bipolar normocalcemic patients , and group C2 , which included bipolar normocalcemic patients treated with anticonvulsant mood stabilizers .
Output: bipolar
CONCLUSIONS : PTU therapy may be related to the appearance of MPO - ANCA , but MPO - ANCA does not appear to be closely related to vasculitis .
Output: vasculitis
Worsening of Parkinsonism after the use of veralipride for treatment of menopause : case report .
Output: Parkinsonism
Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence : a placebo - controlled , double - blind crossover study .
Output: stress incontinence
Half log incremental doses of intravenous methoxamine or placebo ( saline ) were administered to a group of women with genuine stress incontinence while measuring maximum urethral pressure ( MUP ) , blood pressure , heart rate , and symptomatic side effects .
Output: stress incontinence
The results indicate that the clinical usefulness of direct , peripherally acting sub - type - selective alpha1 - adrenoceptor agonists in the medical treatment of stress incontinence may be limited by associated piloerection and cardiovascular side effects .
Output: stress incontinence
Viracept and irregular heartbeat warning .
Output: irregular heartbeat
Anorexigens and pulmonary hypertension in the United States : results from the surveillance of North American pulmonary hypertension .
Output: pulmonary hypertension
MATERIALS AND METHODS : We conducted a prospective surveillance study on patients diagnosed with pulmonary hypertension at 12 large referral centers in North America .
Output: pulmonary hypertension
Data collected on patients seen from September 1 , 1996 , to December 31 , 1997 , included the cause of the pulmonary hypertension and its severity .
Output: pulmonary hypertension
The high prevalence of anorexigen use in patients with SPH also raises the possibility that these drugs precipitate pulmonary hypertension in patients with underlying conditions associated with SPH .
Output: pulmonary hypertension
Both dronedarone and amiodarone significantly reduced the exercise - induced tachycardia and , at the highest dose , decreased the isoproterenol - induced tachycardia .
Output: tachycardia
There was no difference in the maximum double product ( p = 0 . 53 ) or ST depression ( p = 0 . 63 ) with either form of stress .
Output: depression
No necrosis was observed in cells treated with NCQ436 but NCQ344 had a biphasic effect in both cell types , inducing apoptosis at lower concentrations and necrosis at higher concentrations .
Output: necrosis
The effect of pupil dilation with tropicamide on vision and driving simulator performance .
Output: pupil dilation
PURPOSE : To assess the effect of pupil dilation on vision and driving ability .
Output: pupil dilation
METHODS : A series of tests on various parameters of visual function and driving simulator performance were performed on 12 healthy drivers , before and after pupil dilation using guttae tropicamide 1 % .
Output: pupil dilation
A nephrostomy tube had to be placed in one of the patients for ureteral lithiasis in a single functional kidney .
Output: ureteral lithiasis
We report a newborn infant with multiple congenital anomalies ( anotia and Taussig - Bing malformation ) due to exposure to isotretinoin within the first trimester .
Output: anotia
Subgroups presumed to be at higher risk for ACE inhibitor intolerance ( blood pressure , < 120 mm Hg ; creatinine , > or = 132 . 6 micromol / L [ > or = 1 . 5 mg / dL ] ; age , > or = 70 years ; and patients with diabetes ) generally tolerated the high - dose strategy .
Output: diabetes
RESULTS : The patient had episodic deterioration of vision in both eyes , with clinical features resembling ischemic optic neuropathies .
Output: ischemic optic neuropathies
None of the patients had decompensated liver disease .
Output: liver disease
A printout of all cases of hypercalcemia that presented during a 1 - year period was generated .
Output: hypercalcemia
RESULTS : Two of eight dogs in the C + E group experienced cardiovascular collapse .
Output: cardiovascular collapse
Induction of apoptosis by remoxipride metabolites in HL60 and CD34 + / CD19 - human bone marrow progenitor cells : potential relevance to remoxipride - induced aplastic anemia .
Output: aplastic anemia
The antipsychotic agent , remoxipride [ ( S ) - ( - ) - 3 - bromo - N - [ ( 1 - ethyl - 2 - pyrrolidinyl ) methyl ] - 2 , 6 - dimethoxybenz amide ] has been associated with acquired aplastic anemia .
Output: aplastic anemia
We propose that remoxipride and benzene may induce aplastic anemia via production of similar reactive metabolites and that the ability of NCQ436 and NCQ344 to induce apoptosis in HBMP cells may contribute to the mechanism underlying acquired aplastic anemia that has been associated with remoxipride .
Output: aplastic anemia
Deterioration of vision occurred despite discontinuation of the tacrolimus .
Output: Deterioration of vision
Downbeat nystagmus associated with intravenous patient - controlled administration of morphine .
Output: Downbeat nystagmus
RESULTS : Pupillary dilation resulted in a statistically significant deterioration in CT and HCVA only .
Output: Pupillary dilation
CONCLUSIONS : Pupillary dilation may lead to a decrease in vision and daylight driving performance in young people .
Output: Pupillary dilation
Phase 2 trial of liposomal doxorubicin ( 40 mg / m ( 2 ) ) in platinum / paclitaxel - refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum .
Output: cancer
Bradycardia occurred in a 45 - year - old male patient who was Viracept in combination with other anti - HIV drugs .
Output: Bradycardia
7e exhibits a high reversal of catalepsy induced by haloperidol indicating its atypical antipsychotic nature .
Output: catalepsy
Sub - chronic inhibition of nitric - oxide synthesis modifies haloperidol - induced catalepsy and the number of NADPH - diaphorase neurons in mice .
Output: catalepsy
RATIONALE : NG - nitro - L - arginine ( L - NOARG ) , an inhibitor of nitric - oxide synthase ( NOS ) , induces catalepsy in mice .
Output: catalepsy
Neuroleptic drugs such as haloperidol , which block dopamine receptors , also cause catalepsy in rodents .
Output: catalepsy
OBJECTIVES : To investigate the effects of subchronic L - NOARG treatment in haloperidol - induced catalepsy and the number of NOS neurons in areas related to motor control .
Output: catalepsy
RESULTS : L - NOARG sub - chronic administration produced tolerance of L - NOARG and of haloperidol - induced catalepsy .
Output: catalepsy
A case of bilateral optic neuropathy in a patient on tacrolimus ( FK506 ) therapy after liver transplantation .
Output: optic neuropathy
PURPOSE : To report a case of bilateral optic neuropathy in a patient receiving tacrolimus ( FK 506 , Prograf ; Fujisawa USA , Inc , Deerfield , Illinois ) for immunosuppression after orthotropic liver transplantation .
Output: optic neuropathy
The present study examines the safety and tolerability of high - compared with low - dose lisinopril in CHF .
Output: CHF
Patients with New York Heart Association classes II to IV CHF and left ventricular ejection fractions of no greater than 0 . 30 ( n = 3164 ) were randomized and followed up for a median of 46 months .
Output: CHF
CONCLUSIONS : These findings demonstrate that ACE inhibitor therapy in most patients with CHF can be successfully titrated to and maintained at high doses , and that more aggressive use of these agents is warranted .
Output: CHF
Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction .
Output: myocardial infarction
The hemodynamic and antiadrenergic effects of dronedarone , a noniodinated compound structurally related to amiodarone , were compared with those of amiodarone after prolonged oral administration , both at rest and during sympathetic stimulation in conscious dogs with a healed myocardial infarction .
Output: myocardial infarction
The cardioprotective effect of the ethanol extract of Picrorrhiza kurroa rhizomes and roots ( PK ) on isoproterenol - induced myocardial infarction in rats with respect to lipid metabolism in serum and heart tissue has been investigated .
Output: myocardial infarction
Oral pre - treatment with PK ( 80 mg kg ( - 1 ) day ( - 1 ) for 15 days ) significantly prevented the isoproterenol - induced myocardial infarction and maintained the rats at near normal status .
Output: myocardial infarction
Onset of hyperammonemic encephalopathy varied from 0 . 5 to 5 days ( mean : 2 . 6 + / - 1 . 3 days ) after the initiation of chemotherapy .
Output: hyperammonemic encephalopathy
In conclusion , hyperammonemic encephalopathy can occur in patients receiving continuous infusion of 5 - FU .
Output: hyperammonemic encephalopathy
Bleeding is the primary untoward effect of heparin .
Output: Bleeding
Findings consistent with coronary artery disease were detected in 12 ( 34 % ) patients and 3 ( 9 % ) controls ( p = 0 . 01 ) .
Output: coronary artery disease
Major bleeding is of primary concern in patients receiving heparin therapy .
Output: bleeding
The primary efficacy measure was the Young - Mania Rating Scale ( Y - MRS ) total score .
Output: Mania
Heparin , first used to prevent the clotting of blood in vitro , has been clinically used to treat thrombosis for more than 50 years .
Output: thrombosis
DESIGN : A randomised crossover study of recovery time of systolic and diastolic left ventricular function after exercise and dobutamine induced ischaemia .
Output: ischaemia
One patient developed grade 3 diarrhea requiring hospitalization for hydration .
Output: diarrhea
Prevalence of heart disease in asymptomatic chronic cocaine users .
Output: heart disease
To determine the prevalence of heart disease in outpatient young asymptomatic chronic cocaine users , 35 cocaine users and 32 age - matched controls underwent resting and exercise electrocardiography ( ECG ) and Doppler echocardiography .
Output: heart disease
Systemic side effects including piloerection , headache , and cold extremities were experienced in all subjects .
Output: headache
The contribution of transmural dispersion of repolarization ( TDR ) to transmural propagation of EAD and the maintenance of TdP was also evaluated .
Output: TdP
Hyperglycemic effect of amino compounds structurally related to caproate in rats .
Output: Hyperglycemic
Frequency of appearance of myeloperoxidase - antineutrophil cytoplasmic antibody ( MPO - ANCA ) in Graves ' disease patients treated with propylthiouracil and the relationship between MPO - ANCA and clinical manifestations .
Output: Graves ' disease
Therefore , we sought to address these parameters in patients with Graves ' disease .
Output: Graves ' disease
RESULTS : Before treatment , the MPO - ANCA titres of all 102 untreated Graves ' disease patients were within the reference range ( below 10 U / ml ) .
Output: Graves ' disease
However , of the medications surveyed , only the fenfluramines had a significant preferential association with PPH as compared with SPH ( adjusted odds ratio for use > 6 months , 7 . 5 ; 95 % confidence interval , 1 . 7 to 32 . 4 ) .
Output: PPH
CONCLUSION : The magnitude of the association with PPH , the increase of association with increasing duration of use , and the specificity for fenfluramines are consistent with previous studies indicating that fenfluramines are causally related to PPH .
Output: PPH