niryuu/sni-each-converted huggingface dataset:
A case of mania associated with fluoxetine.
Output: fluoxetine
A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.
Output: fluoxetine
Oral 25-hydroxyvitain D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy.
Output: 25-hydroxyvitain D3
Severe histological osteomalacia developed in a woman with Crohn's disease 2 years after ileal resection and the start of cholestyramine therapy.
Output: cholestyramine
Treatment of lithium tremor with metoprolol.
Output: lithium
Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.
Output: lithium carbonate
Intravenous diazepam exacerbated the seizures.
Output: diazepam
A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.
Output: phenytoin
A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.
Output: phenytoin
Transient hemiparesis caused by phenytoin toxicity.
Output: phenytoin
Cefoxitin therapy for Mycobacterium fortuitum bacteremia with associated granulomatous hepatitis.
Output: Cefoxitin
Vasomotor reactions after gold sodium thiomalate are well recognized.
Output: gold sodium thiomalate
Pulmonary gold toxicity.
Output: gold
Cyclophosphamide pneumonitis.
Output: Cyclophosphamide
A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.
Output: disulfiram
Toxic hepatitis induced by disulfiram in a non-alcoholic.
Output: disulfiram
Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.
Output: tamoxifen
Tamoxifen retinopathy.
Output: Tamoxifen
These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.
Output: tamoxifen
Mammary gigantism is a rare complication of D-penicillamine treatment.
Output: D-penicillamine
Ampicillin-associated seizures.
Output: Ampicillin
Two patients had ampicillin-associated seizures.
Output: ampicillin
After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.
Output: rifampicin
Pemphigus foliaceus induced by rifampicin.
Output: rifampicin
Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.
Output: rifampicin
Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.
Output: lorcainide
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.
Output: lorcainide
It is concluded that SIADH is an important side effect of lorcainide therapy.
Output: lorcainide
One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.
Output: hydrochlorothiazide
Chlorpropamide-induced hemolytic anemia.
Output: Chlorpropamide
In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.
Output: amiodarone
Interstitial pneumopathy and low-dosage amiodarone.
Output: amiodarone
The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.
Output: propranolol
This was accepted as evidence for propranolol being the cause of this conduction disorder.
Output: propranolol
A further case of anaphylactoid reaction to methylprednisolone is reported.
Output: methylprednisolone
Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.
Output: methylprednisolone
Although lung specimens were lacking from these three patients, it is suggested that the pulmonary toxicity of CCNU may be dose-related.
Output: CCNU
Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.
Output: CCNU
The responsibility of CCNU in the pathogenesis of pulmonary fibrosis seems very likely.
Output: CCNU
Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.
Output: CCNU
Cholestyramine induced hyperchloremic metabolic acidosis.
Output: Cholestyramine
It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.
Output: cholestyramine
The first reported case, in an adult, of cholestyramine induced hyperchloremic metabolic acidosis is a 70 year old female with a two year history of primary biliary cirrhosis confirmed by histologic and immunologic criteria.
Output: cholestyramine
A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.
Output: amphotericin B
Amphotericin B nephrotoxicity in humans decreased by salt repletion.
Output: Amphotericin B
Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.
Output: amphotericin B
Case report of withdrawal dyskinesia associated with amoxapine.
Output: amoxapine
Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.
Output: amoxapine
The authors describe a case of oral-facial dyskinesia that occurred after discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects.
Output: amoxapine
Metabolic balance studies and rechallenge with hydrochlorothiazide were undertaken to investigate the mechanism of the thiazide-induced hyponatremia.
Output: hydrochlorothiazide
A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).
Output: scopolamine
A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.
Output: deanol
Cephalosporins are most likely associated with Vitamin K deficiency.
Output: Cephalosporins
Moxalactam is more likely to be associated with platelet dysfunction.
Output: Moxalactam
Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.
Output: cephalosporin
A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.
Output: BCNU
Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.
Output: penicillamine
To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.
Output: penicillamine
Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.
Output: amiodarone
To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.
Output: amiodarone
We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.
Output: amiodarone
A 61 year-old male patient developed gynecomastia after starting theophylline.
Output: theophylline
Gynecomastia associated with theophylline.
Output: theophylline
No other endogenous or exogenous cause for the gynecomastia could be found except for the theophylline.
Output: theophylline
The gynecomastia regressed when the theophylline was discontinued.
Output: theophylline
Parenteral-verapamil-induced sustained hypotension.
Output: verapamil
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.
Output: verapamil
We report a case of sustained hypotension after administration of parenteral verapamil.
Output: verapamil
A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.
Output: fenoprofen
Pure red cell aplasia associated with fenoprofen.
Output: fenoprofen
This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.
Output: fenoprofen
Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.
Output: quinacrine hydrochloride
A case of priapism associated with trazodone is described.
Output: trazodone
Priapism associated with trazodone therapy: case report.
Output: trazodone
Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.
Output: paracetamol
Focal renal cortical necrosis associated with zomepirac.
Output: zomepirac
The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.
Output: zomepirac
Cimetidine-induced fever.
Output: Cimetidine
Cimetidine is a rare cause of drug-induced fever.
Output: Cimetidine
A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.
Output: cinepazide
Unique behavioral change with cinepazide in parkinsonism.
Output: cinepazide
A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.
Output: Amphojel
A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.
Output: phenytoin
Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.
Output: gold-salt
Gold nephropathy.
Output: Gold
Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.
Output: Gold-salt
The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.
Output: gold
These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.
Output: chlorpropamide
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.
Output: ergonovine
Catatonia associated with disulfiram therapy.
Output: disulfiram
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.
Output: disulfiram
This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.
Output: disulfiram
Hepatic reactions to cyclofenil.
Output: cyclofenil
Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.
Output: cyclofenil
Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.
Output: theophylline
A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.
Output: desipramine
Desipramine-associated SIADH in an elderly woman: case report.
Output: Desipramine
Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.
Output: rifampin
The spectrum of renal lesions occurring during antituberculous therapy, particularly in association with rifampin, may be wider than previously suspected.
Output: rifampin
Nephrotic range pseudoproteinuria in a tolmetin-treated patient.
Output: tolmetin
When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.
Output: isoniazid
Fulminant hepatitis associated with disulfiram.
Output: disulfiram
We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.
Output: disulfiram
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.
Output: propylthiouracil
The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred.
Output: methimazole
The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency.
Output: asparaginase
Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.
Output: penicillamine
Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.
Output: penicillamine
However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.
Output: prednisone
Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.
Output: disopyramide
Cefoxitin-associated renal failure.
Output: Cefoxitin
Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.
Output: cefoxitin sodium
Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.
Output: SQ 14225
Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.
Output: Amiodarone
Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation cannot be fully ruled out, the sudden onset, prominent magnitude, and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event, possibly related to a transient coronary vasoconstriction induced by the dopamine infusion.
Output: dopamine
Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.
Output: hydroxychloroquine
Hepatitis following cimetidine administration.
Output: cimetidine
There have been only two reports of cimetidine-induced hepatitis.
Output: cimetidine
A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.
Output: digoxin
Verapamil in effort-induced angina pectoris in patients with normal coronary arteries.
Output: Verapamil
Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.
Output: Flucytosine
Ulcerating enteritis associated with flucytosine therapy.
Output: flucytosine
Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.
Output: perhexiline maleate
Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.
Output: L-asparaginase
L-asparaginase-induced pancreatitis has been reported during or closely following administration of the drug.
Output: L-asparaginase
Three cases of pseudocyst of the pancreas in two women and one man have previously been reported with the use of intravenous L-asparaginase.
Output: L-asparaginase
In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.
Output: DCA
Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.
Output: lithium
The course of delirium due to lithium intoxication.
Output: lithium
Life-threatening hyperkalemia induced by arginine.
Output: arginine
Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.
Output: arginine monohydrochloride
A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.
Output: gold
Acne provoked by gold seems not to have been described elsewhere.
Output: gold
The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.
Output: gold
These results indicate that lithium may cause biochemical hyperparathyroidism.
Output: lithium
Disopyramide-induced heart block.
Output: Disopyramide
In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.
Output: bretylium
Nephrotic syndrome associated with lithium therapy.
Output: lithium
Two patients on long-term lithium therapy developed the nephrotic syndrome.
Output: lithium
A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin.
Output: ampicillin
A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.
Output: vincristine
Acute acoustic nerve palsy associated with vincristine therapy.
Output: vincristine
A case of timolol-associated heart failure in a 73-year old white man is reported.
Output: timolol
Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.
Output: digoxin
Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.
Output: L-dopa
The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.
Output: L-dopa
Liver disease induced by perhexiline maleate.
Output: perhexiline maleate
This paper reports a case of fatal perhexiline maleate liver injury.
Output: perhexiline maleate
Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.
Output: Treosulfan
The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.
Output: Treosulfan
Propranolol-related bronchospasm in patients without history of asthma.
Output: Propranolol
Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.
Output: propranolol
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.
Output: propranolol
Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass.
Output: Propranolol
The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.
Output: propranolol
Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.
Output: methotrexate
Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.
Output: methotrexate
Progressive interstitial lung disease from prolonged methotrexate therapy.
Output: methotrexate
Diagnosis: practolol induced sclerosing peritonitis.
Output: practolol
A case of skeletal fluorosis induced by prolonged treatment with niflumic acid, a fast-acting non-steroid antiinflammatory agent, is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated, in addition, with corticosteroids.
Output: niflumic acid
After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.
Output: niflumic acid
Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?
Output: Niflumic acid
The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.
Output: niflumic acid
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.
Output: D-penicillamine
These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.
Output: D-penicillamine
Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine.
Output: D-penicillamine
A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.
Output: metformin
Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.
Output: Para-aminosalicylic acid
The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.
Output: PAS
Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.
Output: 5-fluorouracil
Unusual pigmentary changes associated with 5-fluorouracil therapy.
Output: 5-fluorouracil
Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia.
Output: disulfiram
The authors describe a case of the catatonia syndrome associated with disulfiram therapy.
Output: disulfiram
Inappropriate antidiuretic hormone secretion after high dose vinblastine.
Output: vinblastine
We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.
Output: vinblastine
Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.
Output: emepronium bromide
Oesophageal ulceration due to emepronium bromide.
Output: emepronium bromide
Cardiorespiratory toxicity due to miconazole.
Output: miconazole
None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.
Output: doxorubicin
Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions.
Output: miconazole
Clofibrate-induced myopathy in patients with diabetes insipidus.
Output: Clofibrate
However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.
Output: clofibrate
Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.
Output: clofibrate
Hepatotoxicity of hycanthone in patients with metastatic breast cancer.
Output: hycanthone
In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.
Output: hycanthone
Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.
Output: chlorambucil
Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.
Output: chlorambucil
A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.
Output: barbiturate
Barbiturate-induced submassive hepatic necrosis.
Output: Barbiturate
The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.
Output: barbiturates
A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).
Output: procainamide
Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.
Output: procainamide
The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.
Output: procainamide
We recommended periodic examination of the serum proteins in patients receiving diphenylhydantoin in order to detect development of monoclonal gammopathy.
Output: diphenylhydantoin
CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.
Output: Atovaquone
PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.
Output: atovaquone
Vortex keratopathy associated with atovaquone.
Output: atovaquone
A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.
Output: flecainide
Acute reversible ataxo-myoclonic encephalopathy with flecainide therapy.
Output: flecainide
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.
Output: MTX
Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.
Output: Chlormadinone acetate
Neurological side effects in two patients receiving gold injections for rheumatoid arthritis.
Output: gold
The second patient experienced mild nitritoid symptoms following several GSTM injections prior experiencing a cerebrovascular accident within several hours of her next injection.
Output: GSTM
Acute sensorineural hearing loss following intravenous ketoralac administration.
Output: ketoralac
We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.
Output: ketorolac
We report the case of a 20-year-old female with polyarteritis nodosa (PAN) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac.
Output: ketoralac
Anaphylactoid reactions with intraperitoneal cisplatin.
Output: cisplatin
CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.
Output: cisplatin
CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.
Output: cisplatin
DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.
Output: cisplatin
OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.
Output: cisplatin
We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.
Output: cisplatin
Etoposide-related myocardial infarction.
Output: Etoposide
The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.
Output: etoposide
A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.
Output: acyclovir
Acute renal failure in a child associated with acyclovir.
Output: acyclovir
Anterior ischemic optic neuropathy secondary to interferon alfa.
Output: interferon alfa
CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.
Output: interferon alfa
OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.
Output: interferon alfa
PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.
Output: interferon alfa
CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.
Output: levothyroxine
Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.
Output: adenosine
Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.
Output: adenosine
OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.
Output: propafenone
Probable propafenone-induced transient global amnesia.
Output: propafenone
A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented.
Output: aspirin
Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.
Output: aspirin
Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.
Output: fluvoxamine
However, the occurrence and management of akathisia induced by fluvoxamine have not been described.
Output: fluvoxamine
In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.
Output: fluvoxamine
A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.
Output: bleomycin
Severe bleomycin lung toxicity: reversal with high dose corticosteroids.
Output: bleomycin
This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.
Output: bleomycin
Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).
Output: gold
We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.
Output: gold
Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration.
Output: amphotericin B
I saw two patients with kala-azar resistant to sodium stibogluconate who developed cardiac arrest after amphotericin infusion (in spite of tolerating a test dose).
Output: amphotericin
This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.
Output: IFN
Acute isoniazid neurotoxicity in an urban hospital.
Output: isoniazid
CONCLUSIONS: We have seen an increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.
Output: INH
In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.
Output: INH
Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.
Output: INH
RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.
Output: INH
Arterial hypertension associated with topical ocular use of phenylephrine in dogs.
Output: phenylephrine
CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.
Output: progestin
OBJECTIVE: To report the finding of squamous metaplasia within endometrial glands occurring as a result of progestin therapy of hyperplasia.
Output: progestin
RESULTS: Extensive squamous metaplasia was found in endometrial glands following progestin therapy.
Output: progestin
Fever caused by the use of furosemide was proved; the fever resolved after discontinuation of this medication and recurred after its reintroduction.
Output: furosemide
Furosemide-associated fever.
Output: Furosemide
The dose-limiting toxicity of KW-2149 is pulmonary toxicity.
Output: KW-2149
Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.
Output: ifosfamide
Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.
Output: benzarone
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.
Output: benzarone
Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.
Output: warfarin
Clinicians who manage cachectic patients, particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine, should be aware of the risk of severe hypoglycaemia.
Output: mefloquine
Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.
Output: mefloquine
Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.
Output: Mefloquine
We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.
Output: mefloquine
Because sumatriptan can cause coronary artery vasospasm, patients with significant risk factors for coronary artery disease should be carefully evaluated for cardiovascular disease prior to the use of sumatriptan.
Output: sumatriptan
Cardiac arrest following use of sumatriptan.
Output: sumatriptan
I report a 35-year-old woman with occult coronary artery disease who experienced cardiac arrest within minutes after receiving a first-time dose of subcutaneous sumatriptan for migraine.
Output: sumatriptan
Sotalol-induced bradycardia reversed by glucagon.
Output: Sotalol
We present a case of sotalol-induced bradycardia reversed by glucagon.
Output: sotalol
Secretory endometrial adenocarcinoma in a patient on tamoxifen for breast cancer: a report of a case.
Output: tamoxifen
We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.
Output: tamoxifen
Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.
Output: tamoxifen
Esophageal candidiasis following omeprazole therapy: a report of two cases.
Output: omeprazole
Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.
Output: omeprazole
High-grade atrioventricular block during dipyridamole stress testing.
Output: dipyridamole
We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.
Output: dipyridamole
There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.
Output: doxorubicin
The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.
Output: tamoxifen
Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.
Output: levamisole
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.
Output: levamisole
A case of noncardiogenic pulmonary edema by ethanolamine oleate.
Output: ethanolamine oleate
However, EO-induced noncardiogenic pulmonary edema has not been reported in human.
Output: EO
We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.
Output: EO
Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.
Output: gentamicin sulfate
Gentamicin-associated acute renal failure.
Output: Gentamicin
Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.
Output: gentamicin
A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.
Output: phenytoin
The cases of two asthmatic patients who became hypokalemic after inhalation of normal doses of albuterol are presented.
Output: albuterol
Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.
Output: Propoxyphene
Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.
Output: Propoxyphene
Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.
Output: mannitol
Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.
Output: mannitol
Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.
Output: Mannitol
This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.
Output: mannitol
Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.
Output: fluphenazine decanoate
Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.
Output: benzodiazepine
CASE SUMMARY: A 68-year-old woman developed a dry, irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension.
Output: quinapril
Cough induced by quinapril with resolution after changing to fosinopril.
Output: quinapril
OBJECTIVE: To report a case of chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril, with complete resolution after switching to another ACE inhibitor, fosinopril.
Output: quinapril
The cough continued for the duration of therapy with quinapril.
Output: quinapril
We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.
Output: quinapril
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.
Output: PSL
Cefuroxime-induced acute renal failure.
Output: Cefuroxime
In our patient, DIAN possibly was related to cefuroxime, but the patient did not experience associated allergic symptoms.
Output: cefuroxime
The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.
Output: cefuroxime
This is the first reported case of suspected DIAN due to cefuroxime.
Output: cefuroxime
A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.
Output: phenytoin
His symptoms of brain stem compression were alleviated and the role of phenytoin in the production of his craniocervical abnormality is discussed.
Output: phenytoin
Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.
Output: methotrexate
Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.
Output: methotrexate
Acute pancreatitis associated with danazol treatment for endometriosis.
Output: danazol
Additionally, danazol produces hepatocellular damage in approximately 10% of women.
Output: danazol
Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.
Output: danazol
The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.
Output: danazol
Acyclovir neurotoxicity: clinical experience and review of the literature.
Output: Acyclovir
Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.
Output: Acyclovir
Systemic disease, most commonly renal dysfunction, preceded all 30 reported cases of acyclovir neurotoxicity.
Output: acyclovir
We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.
Output: acyclovir
Response of a promethazine-induced coma to flumazenil.
Output: promethazine
We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.
Output: promethazine
Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.
Output: Actinomycin D
There are now reports of liver failure following treatment of childhood cancers with AMD.
Output: AMD
Phenylpropanolamine-induced psychosis.
Output: Phenylpropanolamine
CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.
Output: budesonide
Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature.
Output: budesonide
METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.
Output: budesonide
RESULTS: Budesonide use can cause contact dermatitis.
Output: Budesonide
Methemoglobinemia: an occupational hazard of phenylpropanolamine production.
Output: phenylpropanolamine
During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.
Output: IFN
Occurrence of IDDM during interferon therapy for chronic viral hepatitis.
Output: interferon
We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.
Output: interferon
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.
Output: carbamazepine
This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin.
Output: clindamycin
There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.
Output: ethambutol
Toxic optic neuropathy associated with ethambutol: implications for current therapy.
Output: ethambutol
Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.
Output: Zidovudine
Celiprolol pneumonitis.
Output: Celiprolol
Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.
Output: celiprolol
We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.
Output: celiprolol
Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.
Output: Ibopamine
Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.
Output: ibopamine
Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.
Output: Diphenylhydantoin
Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.
Output: diphenylhydantoin
A 53-year-old male, without any prior history of psychosis, developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma.
Output: bromocriptine
Bromocriptine-induced schizophrenia.
Output: Bromocriptine
The association of phenothiazine overdose and respiratory distress syndrome merits consideration.
Output: phenothiazine
In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.
Output: apomorphine
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.
Output: levo-dopa
This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.
Output: ddI
Generalized argyria after habitual use of AgNO3.
Output: AgNO3
A case of fluoxetine induced seizures, in a person with Down syndrome, is described.
Output: fluoxetine
Seizures associated with fluoxetine therapy are uncommon.
Output: fluoxetine
Seizures associated with fluoxetine therapy.
Output: fluoxetine
Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.
Output: fluoxetine
A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy.
Output: procainamide
Electrical proarrhythmia with procainamide: a new ICD-drug interaction.
Output: procainamide
The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.
Output: procainamide
Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.
Output: valproic acid
Central nervous system toxicity associated with meperidine use in hepatic disease.
Output: meperidine
Clonidine-induced bradycardia in patients with spinal cord injury.
Output: Clonidine
Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.
Output: nitrous oxide
Neurologic degeneration associated with nitrous oxide anesthesia in patients with vitamin B12 deficiency.
Output: nitrous oxide
Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.
Output: nitrous oxide
BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.
Output: Fluoxetine
Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.
Output: Captopril
Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril.
Output: captopril
We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.
Output: captopril
Can magnesium sulfate therapy impact lactogenesis?
Output: magnesium sulfate
No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.
Output: magnesium sulfate
Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.
Output: Imidazoline
Imidazoline intoxication in children.
Output: Imidazoline
Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.
Output: acyclovir
A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.
Output: lithium
Lithium therapy was discontinued because of poor compliance to the medication and intolerable polyuria.
Output: Lithium
Regression of thyrotoxic ophthalmopathy following lithium withdrawal.
Output: lithium