niryuu/sni-each-converted huggingface dataset:
Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.
Output: danazol
Ifosfamide is a known nephrotoxic drug with demonstrated tubulopathies.
Output: Ifosfamide
Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.
Output: ifosfamide
We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.
Output: ifosfamide
Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.
Output: Ciprofloxacin
Renal toxicities have been reported in less than one percent of the patients receiving ciprofloxacin therapy.
Output: ciprofloxacin
Suspected ciprofloxacin-induced interstitial nephritis.
Output: ciprofloxacin
This article describes a patient with suspected ciprofloxacin-induced interstitial nephritis.
Output: ciprofloxacin
Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.
Output: doxorubicin
Phenobarbital hepatotoxicity in an 8-month-old infant.
Output: Phenobarbital
Severe hepatotoxicity from phenobarbital occurred in an infant boy who had a complicated illness with chronic bilateral subdural hematomas and sepsis.
Output: phenobarbital
Atenolol-induced pseudolymphoma.
Output: Atenolol
Although tardive dyskinesia is a known adverse reaction of sustained treatment with traditional neuroleptic agents, it was only rarely reported in association with sulpiride, a selective D2-receptor antagonist.
Output: sulpiride
Tardive dyskinesia induced by sulpiride.
Output: sulpiride
These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.
Output: sulpiride
We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.
Output: sulpiride
This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.
Output: MTX
Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.
Output: MTX
Although high-dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma, the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure.
Output: methotrexate
The fever abated promptly following discontinuation of acyclovir, and radiographic abnormalities resolved over ten days.
Output: acyclovir
Quinine-induced hearing loss.
Output: Quinine
Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.
Output: quinine
The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.
Output: quinine
The ototoxicity of quinine can accurately be studied with ultrahigh frequency audiometry (up to 20 kHz).
Output: quinine
Bleomycin pneumonitis potentiated by oxygen administration.
Output: Bleomycin
A patient with the Wolff-Parkinson-White syndrome presented with incessant orthodromic atrioventricular tachycardia following initiation of procainamide therapy.
Output: procainamide
Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.
Output: procainamide
In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.
Output: procainamide
Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.
Output: Procainamide
The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.
Output: procainamide
Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.
Output: phosphate diethylstilbestrol
Life-threatening hyponatremia caused by vinblastine.
Output: vinblastine
The most likely cause of such hyponatremic episode is vinblastine.
Output: vinblastine
We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).
Output: bleomycin
A typical case of dextran-40 associated acute renal failure is presented.
Output: dextran-40
Renal failure associated with the use of dextran-40.
Output: dextran-40
Several possible explanations of the mechanism of renal failure associated with the use of dextran-40 are discussed.
Output: dextran-40
While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.
Output: dextran
A 57-year-old man developed morphea while taking bromocriptine.
Output: bromocriptine
Morphea after bromocriptine therapy.
Output: bromocriptine
A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.
Output: dapsone
Dapsone-induced erythroderma with Beau's lines.
Output: Dapsone
Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.
Output: fluoxetine
Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.
Output: fluoxetine
Fluoxetine-induced akathisia: clinical and theoretical implications.
Output: Fluoxetine
Three patients who had experienced neuroleptic-induced akathisia in the past reported that the symptoms of fluoxetine-induced akathisia were identical, although somewhat milder.
Output: fluoxetine
Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.
Output: cytosine arabinoside
Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported.
Output: cytosine arabinoside
Nail-changes induced by penicillamine.
Output: penicillamine
Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.
Output: penicillamine
Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes.
Output: penicillamine
Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.
Output: Ibuprofen
We report a case of ibuprofen-induced meningitis in an otherwise healthy individual.
Output: ibuprofen
Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.
Output: Metoclopramide
Metoclopramide-induced parkinsonism.
Output: Metoclopramide
Their parkinsonism improved on discontinuation of metoclopramide therapy.
Output: metoclopramide
We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.
Output: metoclopramide
Clofazimine induced nail changes.
Output: Clofazimine
These nail changes gradually disappeared when the dose of clofazimine was reduced.
Output: clofazimine
Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.
Output: asparaginase
Development of persistent late onset asthma following treatment with captopril.
Output: captopril
We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.
Output: captopril
Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.
Output: amiodarone
Amiodarone induced torsades de pointe.
Output: Amiodarone
We report three cases of amiodarone-induced torsades de pointe.
Output: amiodarone
The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).
Output: lithium
Long lasting respiratory depression induced by morphine-6-glucuronide?
Output: morphine-6-glucuronide
We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.
Output: morphine
Rifampin-associated thrombocytopenia secondary to poor compliance.
Output: Rifampin
This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.
Output: rifampin
We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.
Output: haloperidol
Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.
Output: haloperidol
Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.
Output: Ibuprofen
Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.
Output: ibuprofen
We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.
Output: ibuprofen
Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.
Output: amiodarone
Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.
Output: amiodarone
Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.
Output: chlorambucil
After the chlorambucil was discontinued, the wbc count began to slowly rise and the patient developed clinical AML.
Output: chlorambucil
Panic anxiety after abrupt discontinuation of mianserin.
Output: mianserin
This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.
Output: mianserin
Prior neurologic illness and the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).
Output: lithium
Prior neurologic illness or CNS insult of any kind is known to increase the vulnerability to neurotoxicity of lithium.
Output: lithium
The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.
Output: lithium
Life-threatening cranial dystonia following trihexyphenidyl withdrawal.
Output: trihexyphenidyl
Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated.
Output: Ara-C
Paraplegia following intrathecal cytosine arabinoside.
Output: cytosine arabinoside
Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.
Output: o,p'-DDD
Alprazolam-induced mania: two clinical cases.
Output: Alprazolam
The authors caution that treatment with alprazolam may be complicated by the induction of mania.
Output: alprazolam
Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.
Output: alprazolam
A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.
Output: alprazolam
Alprazolam withdrawal delirium unresponsive to diazepam: case report.
Output: Alprazolam
We discuss a variety of bronchopulmonary complications of IBD and their association with sulfasalazine.
Output: sulfasalazine
Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.
Output: amantadine
Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.
Output: amantadine
Exacerbation of schizophrenia associated with amantadine.
Output: amantadine
Soon after its introduction in 1952, chlorpromazine was noted to induce symptoms resembling Parkinson's disease.
Output: chlorpromazine
Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.
Output: sulfasalazine
Sulfasalazine-induced lupus erythematosus.
Output: Sulfasalazine
Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy.
Output: L-thyroxine
A study of in vitro reactivity to L-T4, as assessed by peripheral blood lymphocyte transformation, was carried out in a patient with Hashimoto's disease who developed leukopenia during treatment with L-T4.
Output: L-T4
L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.
Output: L-Thyroxine
However, there are few reports in the literature of ampicillin as a cause of acute interstitial nephritis.
Output: ampicillin
Vancomycin-induced vasculitis.
Output: Vancomycin
Abnormal retinal function associated with isotretinoin therapy for acne.
Output: isotretinoin
Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.
Output: FUdR
Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.
Output: Ethambutol
Optic neuropathy in ethambutol-treated renal tuberculosis.
Output: ethambutol
Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.
Output: ethambutol
A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.
Output: nifedipine
Gastro-oesophageal reflux associated with nifedipine.
Output: nifedipine
Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.
Output: Nifedipine
Cataracts induced by intermittent Decadron used as an antiemetic.
Output: Decadron
Recent reports have shown that Decadron (dexamethasone; Merck Sharp & Dohme, West Point, Pa) has a significant antiemetic effect on cisplatin-induced vomiting.
Output: cisplatin
The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.
Output: chloral hydrate
Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.
Output: Adrenaline
Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.
Output: adrenaline
Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.
Output: valproic acid
Reversible valproic acid-induced dementia: a case report.
Output: valproic acid
Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.
Output: valproic acid
Co-trimoxazole red cell aplasia in leukaemia.
Output: Co-trimoxazole
When co-trimoxazole was stopped the red cell aplasia resolved.
Output: co-trimoxazole
A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.
Output: Depo-Medrol
Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.
Output: adrenocorticotropic hormone
Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.
Output: ACTH
We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.
Output: ACTH
Accordingly, camptocormia is a dose-dependent side effect of valproate.
Output: valproate
Camptocormia, a new side effect of sodium valproate.
Output: sodium valproate
A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.
Output: lorazepam
Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.
Output: lorazepam
Atrial fibrillation following methylprednisolone pulse therapy.
Output: methylprednisolone
Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects.
Output: Isotretinoin
Isotretinoin teratogenicity.
Output: Isotretinoin
A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.
Output: allopurinol
Allopurinol hypersensitivity.
Output: Allopurinol
The allopurinol hypersensitivity syndrome is a rare adverse drug reaction.
Output: allopurinol
Bone formation induced in an infant by systemic prostaglandin-E2 administration.
Output: prostaglandin-E2
A case of severe visual loss following a single dose of vincristine is described.
Output: vincristine
Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.
Output: vincristine
Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.
Output: vincristine
The literature of vincristine optic nerve toxicity is reviewed.
Output: vincristine
Visual loss after a single small dose of vincristine has never been reported.
Output: vincristine
Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.
Output: Niacin
Niacin maculopathy.
Output: Niacin
The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.
Output: niacin
A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.
Output: dapsone
Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.
Output: dapsone
Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.
Output: Rifampicin
We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a 'normal' screening test for adrenal insufficiency, yet had clinical evidence of adrenal failure.
Output: rifampicin
Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.
Output: diltiazem
Widespread cutaneous vasculitis associated with diltiazem.
Output: diltiazem
Intraventricular nafcillin-induced seizures in a neonate.
Output: nafcillin
We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.
Output: nafcillin
A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.
Output: streptokinase
Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.
Output: streptokinase
Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.
Output: doxycycline
A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.
Output: human growth hormone
A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.
Output: human growth hormone
A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described.
Output: choline magnesium trisalicylate
Salicylate-induced hepatotoxicity is reviewed.
Output: Salicylate
They continued to rise for five more days before salicylate hepatotoxicity was suspected.
Output: salicylate
Captopril-related (and -induced?) asthma.
Output: Captopril
This confirmed the history of captopril-related asthma.
Output: captopril
We also describe a case of timolol-induced ocular pemphigoid.
Output: timolol
Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.
Output: Benzocaine
Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.
Output: Benzocaine
Methemoglobinemia associated with dermal application of benzocaine cream in a cat.
Output: benzocaine
A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.
Output: methotrexate
Erosion of psoriatic plaques after chronic methotrexate administration.
Output: methotrexate
Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.
Output: cyclosporine A
Polymyositis after propylthiouracil treatment for hyperthyroidism.
Output: propylthiouracil
Cardiopulmonary arrest following intravenous phenytoin loading.
Output: phenytoin
Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.
Output: calcium hopantenate
Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate.
Output: calcium hopantenate
Dyspnea possibly associated with controlled-release morphine sulfate tablets.
Output: morphine sulfate
Anhedonic ejaculation with desipramine.
Output: desipramine
Myoclonic spasms following intrathecal morphine.
Output: morphine
A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.
Output: halothane
Halothane hepatitis and prompt resolution with methionine therapy: case report.
Output: Halothane
Development of porphyria cutanea tarda after treatment with cyclophosphamide.
Output: cyclophosphamide
We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.
Output: PI
D-penicillamine induced crescentic glomerulonephritis: report and review of the literature.
Output: D-penicillamine
The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.
Output: D-penicillamine
Gold-induced pneumonitis is a rare complication of gold salt therapy.
Output: Gold
Gold-induced pneumonitis.
Output: Gold
This case supports the view that in gold-induced pneumonitis a prolonged treatment with corticosteroids may be necessary, as lung function continued to improve.
Output: gold
We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.
Output: gold
Gold-induced aplastic anemia.
Output: Gold
Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.
Output: gold
Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.
Output: 6-mercaptopurine
Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.
Output: HDARAC
Cytarabine-induced cerebellar syndrome: case report and literature review.
Output: Cytarabine
The neurotoxicity seen with HDARAC is dose-related and has occurred in up to 60 percent of treated patients.
Output: HDARAC
This case report illustrates the neurotoxicity unique to HDARAC.
Output: HDARAC
Macular infarction after endophthalmitis treated with vitrectomy and intravitreal gentamicin.
Output: gentamicin
We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.
Output: gentamicin
A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.
Output: razoxane
Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.
Output: gold
Hypogammaglobulinemia associated with gold therapy: evidence for a partial maturation blockade of B cells.
Output: gold
Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.
Output: cyclosporine A
We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy.
Output: Cyclosporine A
With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.
Output: Cyclosporine A
Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.
Output: insulin
Captopril-induced lichen planus pemphigoides with pemphigus-like features.
Output: Captopril
We report a case of a bullous lichenoid eruption due to the intake of captopril.
Output: captopril
An 8-year-old girl, who had been vaccinated with BCG without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later.
Output: BCG
Metastatic osteomyelitis following BCG vaccination.
Output: BCG
Amoxapine-induced cognitive impairment in two patients.
Output: Amoxapine
Two patients are described in whom subtle cognitive impairments are associated with therapeutic doses of amoxapine.
Output: amoxapine
A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.
Output: ibuprofen
Severe systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapy.
Output: ibuprofen
A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.
Output: chloramphenicol
Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.
Output: chloramphenicol
Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.
Output: chloramphenicol
We present a case report of a patient with typhoid fever who experienced a hypersensitivity reaction subsequent to the infusion of chloramphenicol sodium succinate.
Output: chloramphenicol sodium succinate
Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.
Output: penicillamine
We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy.
Output: D-penicillamine
Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.
Output: penicillamine
Other upper tract neoplasms after cyclophosphamide are reviewed.
Output: cyclophosphamide
Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review.
Output: cyclophosphamide
Progressive pulmonary fibrosis complicating cyclophosphamide therapy.
Output: cyclophosphamide
The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.
Output: cyclophosphamide
Torsade de pointes during loading with amiodarone.
Output: amiodarone
Torsade de pointes represents a potential complication of chronic amiodarone therapy.
Output: amiodarone
We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.
Output: amiodarone
Pulmonary edema as a delayed complication of ritodrine therapy.
Output: ritodrine
Rupture of a cerebral aneurysm associated with nifedipine treatment.
Output: nifedipine
We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment.
Output: nifedipine
Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.
Output: Prazosin
A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis.
Output: streptokinase
Massive pulmonary embolism complicating streptokinase treatment for deep vein thrombosis.
Output: streptokinase
Fatal digoxin poisoning: an unsuccessful resuscitation with use of digoxin-immune Fab.
Output: digoxin
Phenytoin-induced hypersensitivity reactions.
Output: Phenytoin
It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.
Output: nicotinic acid
Nicotinic acid-induced fulminant hepatic failure.
Output: Nicotinic acid
The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.
Output: methimazole
A patient with acute changes suggesting acute hepatitis after parenteral amiodarone administration is described.
Output: amiodarone
Probable early acute hepatitis with parenteral amiodarone.
Output: amiodarone
Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.
Output: amiodarone
He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.
Output: timolol
Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist.
Output: timolol
Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.
Output: prednisone
Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.
Output: mono-octanoin
We describe a patient in whom noncardiogenic pulmonary edema developed during intrabiliary infusion of monooctanoin.
Output: monooctanoin
Acute myocardial necrosis during administration of amsacrine.
Output: amsacrine
The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.
Output: phenobarbital
Duodenal ulceration: a complication of tolazoline therapy.
Output: tolazoline
Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.
Output: trazodone
Methimazole-associated cholestatic liver injury: case report and brief literature review.
Output: Methimazole
The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.
Output: methimazole
A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.
Output: interferon beta
The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.
Output: interferon beta
Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.
Output: formalin
A lethal complication of peripheral vein vasopressin infusion.
Output: vasopressin
Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.
Output: protamine
Protamine-induced fatal anaphylaxis.
Output: Protamine
Ototoxicity as a result of cis-platinum administration is well documented.
Output: cis-platinum
Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.
Output: nitroglycerin
Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.
Output: amiodarone
Ampicillin increased the preexisting electrical decrement in three rabbits with experimental autoimmune myasthenia gravis while the drug had no deleterious effects in less affected or normal animals.
Output: Ampicillin
Ampicillin may aggravate clinical and experimental myasthenia gravis.
Output: Ampicillin
Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.
Output: ampicillin
One patient had severe temporary weakness after an ampicillin sodium challenge.
Output: ampicillin sodium
A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.
Output: propranolol
Esophageal spasm following propranolol overdose relieved by glucagon.
Output: propranolol
Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.
Output: hydrochlorothiazide
Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.
Output: verapamil
However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.
Output: verapamil
The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.
Output: verapamil
Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.
Output: amiodarone
Heparin-induced hyperkalemia.
Output: Heparin
We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.
Output: heparin
Careful follow-up of so-called "self-limited" insulin edema is encouraged, and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure.
Output: insulin
Insulin-induced cardiac failure.
Output: Insulin
Self-limited edema is a well-recognized complication of insulin therapy.
Output: insulin
This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.
Output: insulin
A case of pyridoxine-dependent seizures is reported.
Output: pyridoxine
Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia.
Output: pyridoxine
Prolonged severe cholestasis induced by oxacillin derivatives.
Output: oxacillin
Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described.
Output: oxacillin
In all the patients, pellagra symptoms appeared during isoniazid therapy.
Output: isoniazid
Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.
Output: Isoniazid
Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.
Output: isoniazid
Pellagra should be suspected whenever tuberculous patients under treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical pellagra dermatitis.
Output: isoniazid
Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.
Output: aspirin
These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.
Output: aspirin
A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.
Output: amiodarone
Amiodarone-induced dysthyroidism.
Output: Amiodarone
Propranolol-induced hypertension in treatment of cocaine intoxication.
Output: Propranolol
According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome.
Output: chlorambucil
Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.
Output: Chlorambucil
EEG abnormalities were observed in two of the nine children during chlorambucil therapy.
Output: chlorambucil
A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.
Output: fenclofenac
Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.
Output: Fenclofenac
Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.
Output: trazodone
The elicitation of a movement disorder by trazodone: case report.
Output: trazodone
When the trazodone was reduced, the involuntary movements promptly ceased.
Output: trazodone
A review of the literature showed no previous description of this pattern in benzodiazepine coma.
Output: benzodiazepine
Spindle coma in benzodiazepine toxicity: case report.
Output: benzodiazepine
Two reports of spindle coma are noted with alcohol and imipramine.
Output: imipramine
A literature review revealed 83 other reported cases of rifampicin-induced renal insufficiency.
Output: rifampicin
Renal failure is a rare complication associated with the use of rifampicin for the treatment of tuberculosis, usually occurring well into the course of therapy.
Output: rifampicin
Rifampicin-induced renal failure.
Output: Rifampicin
The following is a report of 2 cases of rifampicin-induced renal insufficiency.
Output: rifampicin
Cerebral and ocular toxicity induced by desferrioxamine.
Output: desferrioxamine
Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.
Output: prochlorperazine
Two other patients who did not receive prochlorperazine, developed retinal problems which later improved, one after only 15 g of desferrioxamine.
Output: desferrioxamine
Gold nephropathy: tissue analysis by X-ray fluorescent spectroscopy.
Output: Gold
Three patients developed proteinuria following gold therapy for rheumatoid arthritis.
Output: gold
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).
Output: Intralipid
In all three cases, autopsy revealed gross and microscopic features indistinguishable from those seen in the Hamman-Rich syndrome, and methotrexate hepatotoxicity was present in one.
Output: methotrexate
It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.
Output: methotrexate
Methotrexate-induced diffuse interstitial pulmonary fibrosis.
Output: Methotrexate
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.
Output: methotrexate
Inappropriate antidiuretic hormone following adenine arabinoside administration.
Output: adenine arabinoside
Dystonia associated with carbamazepine administration: experience in brain-damaged children.
Output: carbamazepine
In one child, a second course of carbamazepine resulted in a return of the dystonia.
Output: carbamazepine
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.
Output: carbamazepine
Squamous-cell carcinoma arising in a basal-cell epithelioma treated with 5-fluorouracil.
Output: 5-fluorouracil
We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU.
Output: 5-FU
Lower extremity arterial insufficiency after long-term methysergide maleate therapy.
Output: methysergide maleate
The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.
Output: methysergide
A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described.
Output: Rifampicin
Erythema multiforme bullosum due to rifampicin.
Output: rifampicin
Renal damage associated with long term use of lithium carbonate.
Output: lithium carbonate
The authors report 2 cases of renal damage associated with lithium carbonate treatment.
Output: lithium carbonate
In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).
Output: psoralens
An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma.
Output: acetazolamide
Severe acidosis from acetazolamide in a diabetic patient.
Output: acetazolamide
This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.
Output: aspirin
Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.
Output: clindamycin
An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.
Output: Bromocryptine
Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis.
Output: formalin
Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.
Output: formalin
Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.
Output: formic acid
A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy.
Output: ibuprofen
Edema associated with ibuprofen therapy.
Output: ibuprofen
Allopurinol-associated hand and foot deformities in chronic tophaceous gout.
Output: Allopurinol
Telescoped digits of the hands and feet developed in a 69-year-old male with severe chronic tophaceous gout during allopurinol treatment.
Output: allopurinol
Neurotoxicity of intrathecal administration of amphotericin B.
Output: amphotericin B
In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.
Output: Bleomycin
Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.
Output: doxorubicin
Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.
Output: Doxorubicin
Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.
Output: ouabain
One other patient on digoxin stopped taking it and developed cardiomyopathy.
Output: digoxin
One patient on ouabain also developed cardiomyopathy.
Output: ouabain
A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.
Output: sulindac
In addition, loading with one low oral dose of serine produced psychotic symptoms 5 h later which lasted 3-6 h.
Output: serine
Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.
Output: ergotamine
Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.
Output: Chlorambucil
Anaphylactoid reaction to 50% solution of dextrose.
Output: dextrose
Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.
Output: dextrose
Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.
Output: dextrose
Salicylate hepato toxicity in rheumatic fever.
Output: Salicylate
Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.
Output: aspirin
Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.
Output: penicillamine
Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.
Output: D-penicillamine
The case resembles two previously reported cases of optic neuropathy which occurred in patients with Wilson's disease who were receiving penicillamine.
Output: penicillamine
There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.
Output: Accutane
Allergic contact dermatitis to compound tincture of benzoin.
Output: benzoin
Nineteen cases of allergic contact dermatitis to compound tincture of benzoin are described.
Output: benzoin
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.
Output: cytarabine
Visceral herpesvirus infections in leukemic patients receiving cytarabine.
Output: cytarabine
Clinical and morphological features of gold neuropathy.
Output: gold
Three cases of gold-related neuropathy are reported.
Output: gold
One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.
Output: clofazimine
Severe neurotoxicity with methyl G: CALGB experience.
Output: methyl G: CALGB
A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.
Output: nortriptyline
Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.
Output: nortriptyline
It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.
Output: ACTH
Disulfiram-like reactions with newer cephalosporins: cefmenoxime.
Output: cefmenoxime
This is the first report of a disulfiram-like reaction with cefmenoxime.
Output: cefmenoxime
Acute leukopenia associated with silver sulfadiazine therapy.
Output: silver sulfadiazine
Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease.
Output: prednisone
Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.
Output: captopril
In a patient with severe renovascular hypertension, nonoliguric acute renal failure developed after she received captopril treatment.
Output: captopril
Nonoliguric acute renal failure after captopril therapy.
Output: captopril
Captopril-induced acute reversible renal failure.
Output: Captopril
The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.
Output: captopril
We report 5 cases of acute reversible renal failure coinciding with the onset of treatment with captopril in patients with severe drug-resistant hypertension.
Output: captopril