niryuu/sni-each-converted huggingface dataset:
Intravenous azithromycin-induced ototoxicity.
Output: azithromycin
Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.
Output: dihydrotachysterol
Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.
Output: dihydrotachysterol
Naproxen, the most common offender, has been associated with a dimorphic clinical pattern: a PCT-like presentation and one simulating erythropoietic protoporphyria in the pediatric population.
Output: Naproxen
BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.
Output: clozapine
CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.
Output: clozapine
Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency.
Output: 5-fluorouracil
This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.
Output: BH-AC
In one case, the readministration of riluzole was followed by the relapse of hepatitis.
Output: riluzole
We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.
Output: riluzole
Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.
Output: 5-aminosalicylic acid
Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.
Output: lidocaine
Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.
Output: aspirin
An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.
Output: methotrexate
We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.
Output: epoprostenol
A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.
Output: prednisone
Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.
Output: Hydroxyurea
The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.
Output: hydroxyurea
This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.
Output: hydroxyurea
Allergic and irritant contact dermatitis to calcipotriol.
Output: calcipotriol
The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.
Output: calcipotriol
Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.
Output: pravastatin
Pravastatin is associated with myotonia in animals.
Output: Pravastatin
This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.
Output: pravastatin
CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.
Output: omeprazole
Fixed drug eruption in hands caused by omeprazole.
Output: omeprazole
The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.
Output: omeprazole
Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.
Output: salazosulfapyridine
We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.
Output: salazosulfapyridine
CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).
Output: olanzapine
DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.
Output: Olanzapine
Marked elevation of serum creatine kinase associated with olanzapine therapy.
Output: olanzapine
OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.
Output: olanzapine
Diclofenac-associated hepatitis.
Output: Diclofenac
This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.
Output: diclofenac
2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.
Output: 2-CdA
One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.
Output: heparin
Priapism as a complication of heparin therapy.
Output: heparin
OBJECTIVE: We report a patient who developed neutropenia on clozapine, but behind the cell count decrease showed to be a diurnal variation of the white blood cells (WBC).
Output: clozapine
Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.
Output: all-trans-retinoic acid
Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.
Output: paroxetine
Hair loss associated with paroxetine treatment: a case report.
Output: paroxetine
We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.
Output: paroxetine
CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.
Output: insulin
Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.
Output: neutral protamine Hagedorn (NPH) insulin
Protamine allergy as a complication of insulin hypersensitivity: A case report.
Output: insulin
She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.
Output: insulin
Apparent central nervous system depression in infants after the use of topical brimonidine.
Output: brimonidine
CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.
Output: brimonidine
PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.
Output: brimonidine
Hepato-biliary abnormalities secondary to ceftriaxone use: a case report.
Output: ceftriaxone
Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.
Output: methotrexate
Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.
Output: methotrexate
With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.
Output:  minocycline
We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.
Output: 5-FU
We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.
Output: 5-FU
An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.
Output: venlafaxine
The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.
Output: venlafaxine
This is the first report of a possible association between an acute cardiovascular event and venlafaxine.
Output: venlafaxine
We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.
Output: venlafaxine
Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?
Output: cyclophosphamide
We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.
Output: cyclophosphamide
In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.
Output: phenytoin
Paradoxical seizures in phenytoin toxicity.
Output: phenytoin
We present three patients with paradoxical seizures; their serum phenytoin levels were 43.5 mcg/mL, 46.5 mcg/mL and 38.3 mcg/mL.
Output: phenytoin
CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.
Output: losartan
Losartan-induced angioedema.
Output: Losartan
OBJECTIVE: To report a case of angioedema associated with losartan administration.
Output: losartan
The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.
Output: losartan
We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.
Output: danazol
Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.
Output: Heparin
Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).
Output: heparin
There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.
Output: heparin
Taxane-induced glaucoma.
Output: Taxane
We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.
Output: doxetaxel
Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.
Output: sodium phosphate
We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.
Output: amiodarone
Emphasis is given to the differentiation of diphenylhydantoin induced gingival hyperplasia from the angiomatous enlargement of the gingiva before any treatment is planned.
Output: diphenylhydantoin
Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.
Output: D-Pen
In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.
Output: D-penicillamine
These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.
Output: D-Pen
A 48-year-old woman who was treated for thyrotoxicosis with methimazole developed agranulocytosis.
Output: methimazole
Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.
Output: gemcitabine
The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.
Output: infliximab
The relationship between infliximab treatment and lymphoma in Crohn's disease.
Output: infliximab
The second is a 29-year-old man with CD in whom nodular sclerosing Hodgkin's lymphoma was diagnosed 3 weeks after infusion with infliximab.
Output: infliximab
We describe the clinical course of 2 patients with Crohn's disease (CD) in whom lymphoma was diagnosed after treatment with infliximab.
Output: infliximab
Codeine intoxication in the neonate.
Output: Codeine
We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.
Output: codeine
Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.
Output: HU
We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions.
Output: HU
A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.
Output: oolong tea
After abstinence from oolong tea his delirium resolved.
Output: oolong tea
We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.
Output: indinavir
Elevated serum triglycerides with clozapine resolved with risperidone in four patients.
Output: clozapine
In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased.
Output: clozapine
This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.
Output: clozapine
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.
Output: valproate
To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.
Output: valproate
We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.
Output: valproate
In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.
Output: pyridostigmine
A diagnosis of masked theophylline poisoning should be considered in similar situations involving a rapid decrease of insulin requirements.
Output: theophylline
Salicylate intoxication was excluded, and theophylline was finally incriminated.
Output: theophylline
Theophylline intoxication mimicking diabetic ketoacidosis in a child.
Output: Theophylline
This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.
Output: theophylline
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature.
Output: ifosfamide
Ten to 15% of patients treated with ifosfamide develop an encephalopathy.
Output: ifosfamide
We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.
Output: ifosfamide
Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.
Output: F VIII
We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.
Output: F VIII
A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.
Output: gliclazide
Gliclazide-induced acute hepatitis.
Output: Gliclazide
In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.
Output: gliclazide
We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.
Output: gliclazide
We describe the case of acute hepatitis induced by gliclazide, a second generation sulfonylurea.
Output: gliclazide
Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.
Output: TCA
Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.
Output: TCA
The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).
Output: TCA
Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.
Output: nitrofurantoin
The spectrum of nitrofurantoin lung injury continues to widen.
Output: nitrofurantoin
The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.
Output: nitrofurantoin
We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.
Output: nitrofurantoin
Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.
Output: interferon-alpha
Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.
Output: cyclophosphamide
The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.
Output: cyclophosphamide
This is the first report of UFT-induced scleroderma-like reaction.
Output: UFT
We report a case of a scleroderma-like reaction induced by long-term administration of UFT.
Output: UFT
Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.
Output: ibuprofen
Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.
Output: ibuprofen
We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.
Output: ibuprofen
Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.
Output: Flecainide
We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.
Output: flecainide
We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.
Output: minocycline
We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.
Output: vaccination against hepatitis B
In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.
Output: methotrexate
This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.
Output: cocaine
However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.
Output: troglitazone
Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity.
Output: troglitazone
The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.
Output: troglitazone
Troglitazone-induced fulminant hepatic failure.
Output: Troglitazone
Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.
Output: Nitrofurantoin
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.
Output: Fluoxetine
This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.
Output: fluoxetine
A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.
Output: zolmitriptan
Spinal cord infarction during use of zolmitriptan: a case report.
Output: zolmitriptan
The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.
Output: zolmitriptan
CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.
Output: carboplatin
This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.
Output: carboplatin
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.
Output: nimesulide
This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.
Output: nimesulide
Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.
Output: etoposide
Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?
Output: etoposide
The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.
Output: etoposide
BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.
Output: Cyanamide
Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.
Output: cyanamide
Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.
Output: cyanamide
Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.
Output: Cyanamide
When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.
Output: cyanamide
A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.
Output: tacrolimus
A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.
Output: morphine
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.
Output: naloxone
Nonconvulsive status epilepticus: the role of morphine and its antagonist.
Output: morphine
Spontaneous bacterial peritonitis induced by intraarterial vasopressin therapy.
Output: vasopressin
Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.
Output: CHOP
A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.
Output: methylprednisolone
HUS has been reported after several anticancer chemotherapies and most often after mitomycin C-based chemotherapy regimens.
Output: mitomycin C
An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.
Output: valproate
CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.
Output: valproate
OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.
Output: valproate
PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.
Output: valproate
RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.
Output: valproate
However, recurrent staphylococcus aureus sepsis developed during CyA therapy.
Output: CyA
A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.
Output: colchicine
Colchicine-induced myopathy in renal failure.
Output: Colchicine
A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.
Output: paclitaxel
Physicians should be aware that PLP can occur after initiation of paclitaxel.
Output: paclitaxel
Our experience supports hemodialysis for ESRF patients with atenolol toxicity.
Output: atenolol
Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.
Output: gemfibrozil
We describe a case of EGE manifested as an allergy to gemfibrozil.
Output: gemfibrozil
Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.
Output: propafenone
Propafenone-induced ataxia: report of three cases.
Output: Propafenone
We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone.
Output: propafenone
A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.
Output: pilsicainide
When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.
Output: pilsicainide
The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.
Output: risperidone
Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.
Output: tiagabine
The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.
Output: tiagabine
This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.
Output: tiagabine
There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.
Output: lithium
Protease inhibitor-induced carbamazepine toxicity.
Output: carbamazepine
Anaphylaxis to calcitonin.
Output: calcitonin
CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.
Output: calcitonin
The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.
Output: Miacalcic
Minocycline as a cause of drug-induced autoimmune hepatitis.
Output: Minocycline
Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.
Output: Minocycline
We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).
Output: minocycline
We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.
Output: L-asparaginase
Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.
Output: 5-aminosalicylic acid
We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.
Output: 5-aminosalicylic acid
CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.
Output: vigabatrin
Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.
Output: vigabatrin
PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported.
Output: vigabatrin
The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.
Output: vigabatrin
The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.
Output: vigabatrin
Depressive symptoms disappeared after interferon therapy was stopped.
Output: interferon
While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.
Output: IFN-alpha
Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity.
Output: vancomycin
Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.
Output: vancomycin
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.
Output: hyperbaric oxygen
Nail staining from hydroquinone cream.
Output: hydroquinone
This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.
Output: bleomycin
Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.
Output: warfarin
MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.
Output: PCCs
Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors.
Output: prothrombin complex concentrate
We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI.
Output: PCC
Occult quinine-induced thrombocytopenia.
Output: quinine
Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.
Output: quinine
An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug.
Output: colchicine
CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.
Output: colchicine
In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.
Output: lithium carbonate
This concerns 2 male patients who experienced incontinence while taking venlafaxine.
Output: venlafaxine
Case studies in heparin-induced thrombocytopenia.
Output: heparin
Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time.
Output: heparin
Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.
Output: heparin
After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.
Output: lead
Poorly controlled hypertension in a painter with chronic lead toxicity.
Output: lead
This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity.
Output: lead
Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.
Output: nevirapine
Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.
Output: nevirapine
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.
Output: nevirapine
Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.
Output: acarbose
There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.
Output: losartan
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.
Output: cyclophosphamide
Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.
Output: cyclophosphamide
We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.
Output: cyclophosphamide
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.
Output: cytosine arabinoside
The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.
Output: quetiapine
He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.
Output: clomipramine
Quinine induced coagulopathy--a near fatal experience.
Output: Quinine
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.
Output: quinine
Dose-dependent olanzapine-associated leukopenia: three case reports.
Output: olanzapine
We report three cases of patients who developed leukopenia during olanzapine treatment.
Output: olanzapine
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.
Output: 5-FU
Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.
Output: 5-FU
Ectropion secondary to bolus injection of 5-fluorouracil.
Output: 5-fluorouracil
Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.
Output: 5-FU
Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.
Output: acetazolamide
Renal failure associated with acetazolamide therapy for glaucoma.
Output: acetazolamide
This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.
Output: acetazolamide
Ischaemic colitis in a patient taking meloxicam.
Output: meloxicam
Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal.
Output: meloxicam
We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.
Output: meloxicam
We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity.
Output: meloxicam
As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.
Output: spironolactone
In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.
Output: spironolactone
In some cases this seems to happen because spironolactone causes diarrhoea.
Output: spironolactone
Serious adverse events experienced by patients with chronic heart failure taking spironolactone.
Output: spironolactone
We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.
Output: oxaliplatin
An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.
Output: clofazimine
Clofazimine enteropathy in a pediatric bone marrow transplant recipient.
Output: Clofazimine
She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.
Output: Enoxaparin
Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation.
Output: fludarabine
We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.
Output: fludarabine
CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients.
Output: fluvoxamine
Increased libido in a woman treated with fluvoxamine: a case report.
Output: fluvoxamine
OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.
Output: fluvoxamine
RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.
Output: fluvoxamine
The increased libido disappeared after fluvoxamine was discontinued.
Output: fluvoxamine
An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.
Output: meglumine antimoniate
Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.
Output: meglumine antimoniate
CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.
Output: IFN-alpha
Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.
Output: interferon-alpha
Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.
Output: levodopa
CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.
Output: leflunomide
Leflunomide-associated weight loss in rheumatoid arthritis.
Output: Leflunomide
METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.
Output: leflunomide
OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.
Output: leflunomide
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.
Output: leflunomide
It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.
Output: valacyclovir
Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.
Output: valacyclovir
She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.
Output: valacyclovir
Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.
Output: cyproterone acetate
We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.
Output: cyproterone acetate
Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.
Output: Levofloxacin
We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.
Output: levofloxacin
So far, few cases of pulmonary side effects caused by ticlopidine have been reported.
Output: ticlopidine
Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.
Output: ticlopidine
Ticlopidine-induced interstitial pulmonary disease: a case report.
Output: Ticlopidine
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.
Output: methadone
Methadone-induced myoclonus in advanced cancer.
Output: Methadone
OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy.
Output: succinylcholine
Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.
Output: Succinylcholine
We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.
Output: succinylcholine
Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.
Output: ethanol injection
We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).
Output: ethanol injection
Adenosine-induced ventricular fibrillation.
Output: Adenosine
However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation.
Output: adenosine
We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.
Output: adenosine
After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.
Output: methylprednisolone
Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.
Output: CBZ
We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.
Output: didanosine
This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.
Output: dexamethasone
Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.
Output: metformin
An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.
Output: metformin
Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?
Output: metformin
Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.
Output: amprenavir
The bleeding resolved on discontinuation of APV.
Output: APV
We report the occurrence of spontaneous intracranial bleeding in an human immunodeficiency virus (HIV)-infected adolescent with hemophilia A who was receiving amprenavir (APV).
Output: amprenavir
According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible.
Output: gemcitabine
CONCLUSIONS: We report the first case of gemcitabine-induced LABD.
Output: gemcitabine
Linear immunoglobulin A bullous dermatosis induced by gemcitabine.
Output: gemcitabine
Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.
Output: gemcitabine
Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.
Output: Vancomycin
Although taxol has shown significant activity in advanced ovarian cancer, peripheral neuropathy is likely to become the major dose-limiting toxicity.
Output: taxol
A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.
Output: paclitaxel
Relief by naloxone of morphine-induced spasm of the sphincter of Oddi in a post-cholecystectomy patient.
Output: morphine
Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.
Output: IFN-alpha
A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.
Output: sodium aurothiomalate
BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.
Output: Accutane
RESULTS: The estimated number of Accutane prescriptions for reproductive-aged women has more than doubled in the past 10 years; it is the most widely used teratogenic drug in the United States, with approximately 2.5 per 1,000 reproductive-aged women exposed to Accutane in 1999.
Output: Accutane
An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.
Output: indinavir
Papillary necrosis associated with the HIV protease inhibitor indinavir.
Output: indinavir
The renal consequences of indinavir-associated nephrotoxicity are uncertain.
Output: indinavir
We report a case of papillary necrosis in a patient treated with indinavir.
Output: indinavir
We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.
Output: rofecoxib
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.
Output: LTG
Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.
Output: LTG
PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy.
Output: lamotrigine
Stupor from lamotrigine toxicity.
Output: lamotrigine
The cause of death was determined to be acute intoxication by olanzapine, and the manner of death was accidental.
Output: olanzapine
This article describes the case of a 25-year-old man found dead at home who had been prescribed olanzapine for schizophrenia.
Output: olanzapine
Lichenoid drug eruption to salsalate.
Output: salsalate
This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.
Output: salsalate
We describe a patient who experienced a lichenoid eruption after the initiation of salsalate for relief of arthritic pain.
Output: salsalate
Amphotericin B-induced seizures in a patient with AIDS.
Output: Amphotericin B