Context: French Guiana (pronounced or ), officially called Guiana, is an overseas department and region of France, located on the north Atlantic coast of South America in the Guyanas. It borders Brazil to the east and south, and Suriname to the west. Its area has a very low population density of only 3 inhabitants per km, with half of its 244,118 inhabitants in 2013 living in the metropolitan area of Cayenne, its capital. By land area, it is the second largest region of France and the largest outermost region within the European Union., Vertebrates comprise all species of animals within the subphylum Vertebrata (chordates with backbones). Vertebrates represent the overwhelming majority of the phylum Chordata, with currently about 64,000 species described. Vertebrates include the jawless fish and the jawed vertebrates, which include the cartilaginous fish (sharks and rays) and the bony fish. , Jean-Baptiste-Gabriel-Joachim Dausset (19 October 1916  6 June 2009) was a French immunologist born in Toulouse, France. Dausset received the Nobel Prize in Physiology or Medicine in 1980 along with Baruj Benacerraf and George Davis Snell for their discovery and characterisation of the genes making the major histocompatibility complex. Using the money from his Nobel Prize and a grant from the French Television, Dausset founded the Human Polymorphism Study Center (CEPH) in 1984, which was later renamed the Foundation Jean Dausset-CEPH in his honour. He married Rose Mayoral in 1963, with whom he had two children, Henri and Irène. Jean Dausset died on June 6, 2009 in Majorca, Spain, at the age of 92., France, officially the French Republic, is a country with territory in western Europe and several overseas regions and territories. The European, or metropolitan, area of France extends from the Mediterranean Sea to the English Channel and the North Sea, and from the Rhine to the Atlantic Ocean. Overseas France include French Guiana on the South American continent and several island territories in the Atlantic, Pacific and Indian oceans. France spans and had a total population of almost 67 million people as of January 2017. It is a unitary semi-presidential republic with the capital in Paris, the country's largest city and main cultural and commercial centre. Other major urban centres include Marseille, Lyon, Lille, Nice, Toulouse and Bordeaux., A republic (from ) is a sovereign state, country, or government which is organized with a form of government in which power resides in elected individuals representing the citizen body and government leaders exercise power according to the rule of law. In modern times, the definition of a republic commonly refers to a government which excludes a monarch. Currently, 147 of the world's 206 sovereign states use the word "republic" as part of their official names; not all of these are republics in the sense of having elected governments, nor do all nations with elected governments use the word "republic" in their names., Melilla ( "Maliliyyah") is a Spanish autonomous city located on the north coast of Africa, sharing a border with Morocco with an area of . Melilla, along with Ceuta, is one of two permanently inhabited Spanish cities in mainland Africa. It was part of Málaga province until 14 March 1995 when the city's Statute of Autonomy was passed. , Andorra, officially the Principality of Andorra, also called the Principality of the Valleys of Andorra, is a sovereign landlocked microstate in Southwestern Europe, located in the eastern Pyrenees mountains and bordered by Spain and France. Created under a charter in 988, the present principality was formed in 1278. It is known as a principality as it is a monarchy headed by two Co-Princes the Roman Catholic Bishop of Urgell in Spain, and the President of France., The Nobel Prize in Physiology or Medicine, administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the fields of life sciences and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will. Nobel was personally interested in experimental physiology and wanted to establish a prize for progress through scientific discoveries in laboratories. The Nobel Prize is presented to the recipient(s) at an annual ceremony on 10 December, the anniversary of Nobel's death, along with a diploma and a certificate for the monetary award. The front side of the medal provides the same profile of Alfred Nobel as depicted on the medals for Physics, Chemistry, and Literature; its reverse side is unique to this medal., The Nobel Foundation is a private institution founded on 29 June 1900 to manage the finances and administration of the Nobel Prizes. The Foundation is based on the last will of Alfred Nobel, the inventor of dynamite., The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility. The main function of MHC molecules is to bind to antigens derived from pathogens and display them on the cell surface for recognition by the appropriate T-cells. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or with body cells. The MHC determines compatibility of donors for organ transplant, as well as one's susceptibility to an autoimmune disease via crossreacting immunization. The human MHC is also called the HLA (human leukocyte antigen) complex (often just the HLA). The mouse MHC is called the H-2 complex or H-2., Alfred Bernhard Nobel (21 October 1833  10 December 1896) was a Swedish chemist, engineer, inventor, businessman, and philanthropist., Toulouse is the capital city of the southwestern French department of Haute-Garonne, as well as of the Occitanie region. The city lies on the banks of the River Garonne, from the Mediterranean Sea, from the Atlantic Ocean, and from Paris. It is the fourth-largest city in France with 466,297 inhabitants in January 2014. 
The Toulouse Metro area is, with 1 312 304 inhabitants as of 2014, France's 4th metropolitan area after Paris, Lyon and Marseille and ahead of Lille and Bordeaux., Gibraltar is a British Overseas Territory located on the southern end of the Iberian Peninsula. It has an area of and shares its northern border with Spain. The Rock of Gibraltar is the major landmark of the region. At its foot is a densely populated city area, home to over 30,000 Gibraltarians and other nationalities., Nice (; Niçard , classical norm, or "", nonstandard,  ) is the fifth most populous city in France and the capital of the Alpes-Maritimes "département". The urban area of Nice extends beyond the administrative city limits, with a population of about 1 million on an area of . Located in the French Riviera, on the south east coast of France on the Mediterranean Sea, at the foot of the Alps, Nice is the second-largest French city on the Mediterranean coast and the second-largest city in the Provence-Alpes-Côte d'Azur region after Marseille. Nice is about 13 kilometres (8 miles) from the principality of Monaco, and its airport is a gateway to the principality as well., Baruj Benacerraf (October 29, 1920  August 2, 2011) was a Venezuelan-born American immunologist, who shared the 1980 Nobel Prize in Physiology or Medicine for the "discovery of the major histocompatibility complex genes which encode cell surface protein molecules important for the immune system's distinction between self and non-self". His colleagues and shared recipients were Jean Dausset and George Davis Snell., Ceuta (assimilated pronunciation , also  Arabic: , "Sabtah") is an Spanish autonomous city located on the north coast of Africa, sharing a western border with Morocco. Separated from the Iberian peninsula by the Strait of Gibraltar, Ceuta lies along the boundary between the Mediterranean Sea and the Atlantic Ocean. Ceuta, along with the Spanish exclave Melilla, is one of nine populated Spanish territories in Africa and one of two populated territories on mainland Africa. It was part of Cádiz province until 14 March 1995 when the city's Statute of Autonomy was passed., Dynamite is an explosive made of nitroglycerin, sorbents (such as powdered shells or clay) and stabilizers. It was invented by the Swedish chemist and engineer Alfred Nobel in Geesthacht, and patented in 1867. It rapidly gained wide-scale use as a safer alternative to gun powder and nitroglycerin., Jean - Baptiste - Gabriel - Joachim Dausset ( October 19 , 1916 -- June 6 , 2009 ) was a French immunologist born in Toulouse , France . Dausset received the Nobel Prize in Physiology or Medicine in 1980 along with Baruj Benacerraf and George Davis Snell for their discovery and characterisation of the genes making the major histocompatibility complex . Using the money from his Nobel Prize and a grant from the French Television , Dausset founded the Human Polymorphism Study Center ( CEPH ) in 1984 , which was later renamed the Foundation Jean Dausset - CEPH in his honour . He married Rose Mayoral in 1963 , with whom he had two children , Henri and Irène . Jean Dausset died on June 6 , 2009 in Majorca , Spain , at the age of 92 ., The Atlantic Ocean is the second largest of the world's oceans with a total area of about . It covers approximately 20 percent of the Earth's surface and about 29 percent of its water surface area. It separates the "Old World" from the "New World"., Paris (French: ) is the capital and most populous city of France. It has an area of and a population in 2013 of 2,229,621 within its administrative limits. The city is both a commune and department, and forms the centre and headquarters of the Île-de-France, or Paris Region, which has an area of and a population in 2014 of 12,005,077, comprising 18.2 percent of the population of France., Africa is the world's second-largest and second-most-populous continent. At about 30.3 million km² (11.7 million square miles) including adjacent islands, it covers 6% of Earth's total surface area and 20.4 % of its total land area. With 1.1 billion people as of 2013, it accounts for about 15% of the world's human population. The continent is surrounded by the Mediterranean Sea to the north, both the Suez Canal and the Red Sea along the Sinai Peninsula to the northeast, the Indian Ocean to the southeast, and the Atlantic Ocean to the west. The continent includes Madagascar and various archipelagos. It contains 54 fully recognized sovereign states (countries), nine territories and two "de facto" independent states with limited or no recognition., Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA). Histocompatibility and histocompatibility testing is most relevant for topics related to whole organ, tissue, or stem cell transplants. HLA is the human form of the major histocompatibility complex (MHC) genes found in all vertebrates. On a population level there is a great number of different alleles at each HLA locus on chromosome 6 at 6p21.3 in humans with new ones being continuously discovered. Each individual inherits two different HLA alleles. Each of these alleles contain six loci (location on the chromosome) which code for major histocompatibility complex (MHC) proteins. These genes are codominantly expressed meaning every individual expresses each of the inherited alleles, both paternal and maternal. This results in a mixture of different types of MHC proteins for every individual. The similarity or difference of one individual's HLA alleles, and therefore MHC proteins, to another person's is what makes the tissues either compatible or incompatible., Spain, officially the Kingdom of Spain, is a sovereign state largely located on the Iberian Peninsula in southwestern Europe, with two large archipelagos, the Balearic Islands in the Mediterranean Sea and the Canary Islands off the North African Atlantic coast, two cities Ceuta and Melilla in the North African mainland and several small islands in the Alboran Sea near the Moroccan coast. Its mainland is bordered to the south and east by the Mediterranean Sea except for a small land boundary with Gibraltar; to the north and northeast by France, Andorra, and the Bay of Biscay; and to the west and northwest by Portugal and the Atlantic Ocean. It is the only European country to have a border with an African country (Morocco) and its African territory accounts for nearly 5% of its population, mostly in the Canary Islands but also in Ceuta and Melilla., An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases. Nearly any body part can be involved. Common symptoms include low grade fever and feeling tired. Often symptoms come and go.
The cause is generally unknown. Some autoimmune diseases such as lupus run in families, and certain cases may be triggered by infections or other environmental factors. Some common autoimmune disease include celiac disease, diabetes mellitus type 1, Graves disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus. The diagnosis can be difficult to determine.
Treatment depends on the type and severity of the condition. Nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressants are often used. Intravenous Immunoglobulin may also occasionally be used. While treatment usually improves symptoms they do not typically cure the disease.
About 24 million (7%) of people in the United States are affected by an autoimmune disease. Women are more commonly affected than men. Often they start during adulthood. The first autoimmune diseases were described in the early 1900s., The Rhine (, , ) is a European river that begins in the Swiss canton of Graubünden in the southeastern Swiss Alps, forms part of the 
Swiss-Austrian, Swiss-Liechtenstein, Swiss-German and then the Franco-German border, then flows through the Rhineland and eventually empties into the North Sea in the Netherlands. 
The largest city on the river Rhine is Cologne, Germany, with a population of more than 1,050,000 people. It is the second-longest river in Central and Western Europe (after the Danube), at about , with an average discharge of about ., The Toulouse metro serves the city of Toulouse, France, and some of the surrounding area. The city's public transport system was initially managed by "Société d'économie mixte des voyageurs de l'agglomération toulousaine" (SEMVAT), which was a company that was 80% owned by local government bodies and 20% privately owned. It has been managed by "Tisséo", under the authority of the "Syndicat Mixte des Transports en Commun" (an authority established by various local government bodies) since 2003., The euro (sign: €; code: EUR) is the official currency of the eurozone, which consists of 19 of the member states of the European Union: Austria, Belgium, Cyprus, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Portugal, Slovakia, Slovenia, and Spain. The currency is also officially used by the institutions of the European Union and four other European countries, as well as unilaterally by two others, and is consequently used daily by some 337 million Europeans . Outside of Europe, a number of overseas territories of EU members also use the euro as their currency., George Davis Snell (December 19, 1903  June 6, 1996) was an American mouse geneticist and basic transplant immunologist., Subject: jean dausset, Relation: date_of_death, Options: (A) 1 (B) 10 december 1896 (C) 118 (D) 1278 (E) 13 (F) 14 (G) 147 (H) 18 (I) 1833 (J) 1867 (K) 1895 (L) 19 (M) 1916 (N) 1920 (O) 1984 (P) 1996 (Q) 2 (R) 20 (S) 2009 (T) 2013 (U) 21 (V) 229 (W) 244 (X) 29 (Y) 29 june 1900 (Z) 30 ([) 304 (\) 312 (]) 4 (^) 466 (_) 6 (`) 6 june 2009 (a) 621 (b) 64 (c) 67 (d) 7 (e) 80 (f) 988 (g) january 2014 (h) june 1900 (i) june 2009 (j) march 1995
Output: 6 june 2009