Context: Castleman disease, also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia, is a group of uncommon lymphoproliferative disorders that share common lymph node histological features that may be localized to a single lymph node (unicentric) or occur systemically (multicentric). It is named after Benjamin Castleman., Murid herpesvirus 4 ( MuHV 4 ) is a virus in the genus Rhadinovirus . It is a member of the subfamily Gammaherpesvirinae in the family Herpesviridae . MuHV 4 infects mice via the nasal passages and causes an acute infectious mononucleosis - like syndrome with elevated levels of leukocytes , and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells . Murid herpesvirus 4 currently serves as a model for study of human gamma - herpesvirus pathogenesis . Seven strains of MuHV 4 have been isolated , including the following six : MHV - Šum MHV - 60 MHV - 68 MHV - 72 MHV - 76 MHV - 4556, A DNA virus is a virus that has DNA as its genetic material and replicates using a DNA-dependent DNA polymerase. The nucleic acid is usually double-stranded DNA (dsDNA) but may also be single-stranded DNA (ssDNA). DNA viruses belong to either "Group I" or "Group II" of the Baltimore classification system for viruses. Single-stranded DNA is usually expanded to double-stranded in infected cells. Although "Group VII" viruses such as hepatitis B contain a DNA genome, they are not considered DNA viruses according to the Baltimore classification, but rather reverse transcribing viruses because they replicate through an RNA intermediate. Notable diseases like smallpox, herpes, and chickenpox are caused by such DNA viruses., The Herpesvirales is an order of viruses all sharing the same overall morphology., Bacteria (common noun bacteria, singular bacterium) constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a number of shapes, ranging from spheres to rods and spirals. Bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep portions of Earth's crust. Bacteria also live in symbiotic and parasitic relationships with plants and animals., A virus is a small infectious agent that replicates only inside the living cells of other organisms. Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea., The Archaea (or or ) constitute a domain and kingdom of single-celled microorganisms. These microbes (archaea; singular archaeon) are prokaryotes, meaning that they have no cell nucleus or any other membrane-bound organelles in their cells., Deoxyribonucleic acid (DNA) is a molecule that carries the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. DNA and RNA are nucleic acids; alongside proteins, lipids and complex carbohydrates (polysaccharides), they are one of the four major types of macromolecules that are essential for all known forms of life. Most DNA molecules consist of two biopolymer strands coiled around each other to form a double helix., Herpesviridae is a large family of DNA viruses that cause diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word "herpein" ("to creep"), referring to the latent, recurring infections typical of this group of viruses. "Herpesviridae" can cause latent or lytic infections., Infectious mononucleosis (IM), also known as mono, or glandular fever, is an infection commonly caused by the EpsteinBarr virus (EBV). Most people are infected by the virus as children, when the disease produces little or no symptoms. In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and feeling tired. Most people get better in two to four weeks; however, feeling tired may last for months. The liver or spleen may also become swollen. In less than one percent of cases splenic rupture may occur.
Infectious mononucleosis is usually caused by EpsteinBarr virus (EBV), also known as human herpesvirus 4, which is a member of the herpes virus family. A few other viruses may also cause the disease. It is primarily spread through saliva but can rarely be spread through semen or blood. Spread may occur by objects such as drinking glasses or toothbrushes. Those who are infected can spread the disease weeks before symptoms develop. Mono is primarily diagnosed based on the symptoms and can be confirmed with blood tests for specific antibodies. Another typical finding is increased blood lymphocytes of which more than 10% are atypical. The monospot test is not recommended for general use due to poor accuracy.
There is no vaccine for EBV. Prevention is by not sharing personal items or kissing those infected. Mono generally gets better on its own. Recommendations include drinking enough fluids, getting sufficient rest, and taking pain medications such as paracetamol (acetaminophen) and ibuprofen.
Mono most commonly affects those between the ages of 15 to 24 years in the developed world. In the developing world, people are more often infected in early childhood when the symptoms are less. In those between 16 and 20 it is the cause of about 8% of sore throats. About 45 out of 100,000 people develop mono each year in the United States. Nearly 95% of people have been infected by the time they are adults. The disease occurs equally at all times of the year. Mononucleosis was first described in the 1920s and is colloquially known as "the kissing disease"., Plants are mainly multicellular, predominantly photosynthetic eukaryotes of the kingdom Plantae., Animals are multicellular, eukaryotic organisms of the kingdom Animalia (also called Metazoa). The animal kingdom emerged as a basal clade within Apoikozoa as a sister of the choanoflagellates. Sponges are the most basal clade of animals. Animals are motile, meaning they can move spontaneously and independently at some point in their lives. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later in their lives. All animals are heterotrophs: they must ingest other organisms or their products for sustenance., The EpsteinBarr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known viruses in the herpes family, and is one of the most common viruses in humans., Rhadinovirus (also known as "Rhadinoviridae" and gamma-2 herpesviruses) is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Human and mammals serve as natural hosts. There are currently nine species in this genus including the type species Saimiriine herpesvirus 2. Diseases associated with this genus include: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease, caused by Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). The term rhadino comes from the Latin fragile, referring to the tendency of the viral genome to break apart when it is isolated., Gammaherpesvirinae is a subfamily of viruses in the order Herpesvirales, in the family Herpesviridae. Viruses in "Gammaherpesvirinae" are distinguished by reproducing at a more variable rate than other subfamilies of Herpesviridae. Mammals serve as natural hosts. There are currently 32 species in this subfamily, divided among 4 genera. Diseases associated with this subfamily include: HHV-4: infectious mononucleosis. HHV-8: kaposi's sarcoma., Subject: murid herpesvirus 4, Relation: taxon_rank, Options: (A) domain (B) family (C) form (D) genus (E) group (F) kingdom (G) order (H) species (I) subfamily
Output: species