Context: Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiologic processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior., Ancient Egypt was a civilization of ancient Northeastern Africa, concentrated along the lower reaches of the Nile River in what is now the modern country of Egypt. It is one of six civilizations to arise independently. Egyptian civilization followed prehistoric Egypt and coalesced around 3150 BC (according to conventional Egyptian chronology) with the political unification of Upper and Lower Egypt under the first pharaoh Narmer (commonly referred to as Menes). The history of ancient Egypt occurred in a series of stable kingdoms, separated by periods of relative instability known as Intermediate Periods: the Old Kingdom of the Early Bronze Age, the Middle Kingdom of the Middle Bronze Age and the New Kingdom of the Late Bronze Age., Magnesium sulphate is an inorganic salt (chemical compound) containing magnesium, sulfur and oxygen, with the formula MgSO. It is often encountered as the heptahydrate sulfate mineral epsomite (MgSO·7HO), commonly called Epsom salt. The monohydrate, MgSO·HO is found as the mineral kieserite. The overall global annual usage in the mid-1970s of the monohydrate was 2.3 million tons, of which the majority was used in agriculture., An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies., Levosalbutamol or levalbuterol is a short - acting 2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease ( COPD ) . It is marketed under the brand name Xopenex by Sunovion Pharmaceuticals Inc. The drug is the ( R ) - (  ) - enantiomer of its prototype drug salbutamol ( INN ) or albuterol ( USAN ) . It is available in some countries in generic formulations from pharmaceutical companies including Cipla , Teva , and Dey , among others . Evidence does not show that levosalbutamol works better than salbutamol , thus there may not be sufficient justification for prescribing it ., A gene is a locus (or region) of DNA which is made up of nucleotides and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as geneenvironment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life., Asthma is a common long term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. These episodes may occur a few times a day or a few times per week. Depending on the person they may become worse at night or with exercise.
Asthma is thought to be caused by a combination of genetic and environmental factors. Environmental factors include exposure to air pollution and allergens. Other potential triggers include medications such as aspirin and beta blockers. Diagnosis is usually based on the pattern of symptoms, response to therapy over time, and spirometry. Asthma is classified according to the frequency of symptoms, forced expiratory volume in one second (FEV1), and peak expiratory flow rate. It may also be classified as atopic or non-atopic where atopy refers to a predisposition toward developing a type 1 hypersensitivity reaction.
There is no cure for asthma. Symptoms can be prevented by avoiding triggers, such as allergens and irritants, and by the use of inhaled corticosteroids. Long-acting beta agonists (LABA) or antileukotriene agents may be used in addition to inhaled corticosteroids if asthma symptoms remain uncontrolled. Treatment of rapidly worsening symptoms is usually with an inhaled short-acting beta-2 agonist such as salbutamol and corticosteroids taken by mouth. In very severe cases, intravenous corticosteroids, magnesium sulfate, and hospitalization may be required.
In 2013, 242 million people globally had asthma up from 183 million in 1990. It caused about 489,000 deaths in 2013, most of which occurred in the developing world. It often begins in childhood. The rates of asthma have increased significantly since the 1960s. Asthma was recognized as early as Ancient Egypt. The word asthma is from the Greek , "ásthma" which means "panting"., A cough is a sudden and often repetitively occurring reflex which helps to clear the large breathing passages from fluids, irritants, foreign particles and microbes. The cough reflex consists of three phases: an inhalation, a forced exhalation against a closed glottis, and a violent release of air from the lungs following opening of the glottis, usually accompanied by a distinctive sound. Coughing is either voluntary or involuntary., An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist., Spirometry (meaning "the measuring of breath") is the most common of the pulmonary function tests (PFTs). It measures lung function, specifically the amount (volume) and/or speed (flow) of air that can be inhaled and exhaled. Spirometry is helpful in assessing breathing patterns that identify conditions such as asthma, pulmonary fibrosis, cystic fibrosis, and COPD. It is also helpful as part of a system of health surveillance, in which breathing patterns are measured over time., Bronchospasm or a bronchial spasm is a sudden constriction of the muscles in the walls of the bronchioles. It is caused by the release (degranulation) of substances from mast cells or basophils under the influence of anaphylatoxins. It causes difficulty in breathing which can be very mild to severe., Air pollution is the introduction of harmful substances including particulates and biological molecules into Earth's atmosphere. It may cause diseases, allergies or death in humans; it may also cause harm to other living organisms such as animals and food crops, and may damage the natural or built environment. Human activity and natural processes can both generate air pollution., Shortness of breath, also known as dyspnea, is a feeling like one cannot breathe well enough. The American Thoracic Society defines it as "a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity", and recommends evaluating dyspnea by assessing the intensity of the distinct sensations, the degree of distress involved, and its burden or impact on activities of daily living. Distinct sensations include effort/work, chest tightness, and air hunger (the feeling of not enough oxygen)., In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist. A neutral antagonist has no activity in the absence of an agonist or inverse agonist but can block the activity of either., Environmental factor or ecological factor or ecofactor is any factor, abiotic or biotic, that influences living organisms. Abiotic factors include ambient temperature, amount of sunlight, and pH of the water soil in which an organism lives. Biotic factors would include the availability of food organisms and the presence of conspecifics, competitors, predators, and parasites., Subject: levosalbutamol, Relation: instance_of, Options: (A) 1 (B) acting (C) activity (D) addition (E) agonist (F) air pollution (G) antagonist (H) antigen (I) atmosphere (J) cause (K) chemical (L) chemical compound (M) chest (N) civilization (O) class (P) combination (Q) damage (R) day (S) dna (T) environmental factor (U) field (V) formula (W) frequency (X) function (Y) gene (Z) health ([) history (\) humans (]) inflammation (^) may (_) organism (`) person (a) protein (b) range (c) reflex (d) region (e) regulation (f) release (g) river (h) society (i) soil (j) stable (k) sulphate (l) temperature (m) term (n) three (o) time (p) treatment (q) two (r) variable (s) work
Output: chemical compound