Context: Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are currently ten species in this genus including the type species vaccinia virus. Diseases associated with this genus include smallpox, cowpox, horsepox, and monkeypox. The most famous member of the genus is variola virus, which causes smallpox. Variola was eradicated using vaccinia virus as a vaccine., A virus is a small infectious agent that replicates only inside the living cells of other organisms. Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea., The Archaea (or or ) constitute a domain and kingdom of single-celled microorganisms. These microbes (archaea; singular archaeon) are prokaryotes, meaning that they have no cell nucleus or any other membrane-bound organelles in their cells., Life is a characteristic distinguishing physical entities having biological processes, such as signaling and self-sustaining processes, from those that do not, either because such functions have ceased, or because they never had such functions and are classified as inanimate. Various forms of life exist, such as plants, animals, fungi, protists, archaea, and bacteria. The criteria can at times be ambiguous and may or may not define viruses, viroids, or potential artificial life as "living". Biology is the primary science concerned with the study of life, although many other sciences are involved., Vertebrates comprise all species of animals within the subphylum Vertebrata (chordates with backbones). Vertebrates represent the overwhelming majority of the phylum Chordata, with currently about 64,000 species described. Vertebrates include the jawless fish and the jawed vertebrates, which include the cartilaginous fish (sharks and rays) and the bony fish. , Poxviridae is a family of viruses. Human, vertebrates, and arthropods serve as natural hosts. There are currently 69 species in this family, divided among 28 genera, which are divided into two subfamilies. Diseases associated with this family include smallpox., Smallpox was an infectious disease caused by either of two virus variants, "Variola major" and "Variola minor". The disease is also known by the Latin names variola or variola vera, derived from "varius" ("spotted") or "varus" ("pimple"). The disease was originally known in English as the "pox" or "red plague"; the term "smallpox" was first used in Britain in the 15th century to distinguish variola from the "great pox" (syphilis). The last naturally occurring case of smallpox ("Variola minor") was diagnosed on 26 October 1977., Animals are multicellular, eukaryotic organisms of the kingdom Animalia (also called Metazoa). The animal kingdom emerged as a basal clade within Apoikozoa as a sister of the choanoflagellates. Sponges are the most basal clade of animals. Animals are motile, meaning they can move spontaneously and independently at some point in their lives. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later in their lives. All animals are heterotrophs: they must ingest other organisms or their products for sustenance., Bacteria (common noun bacteria, singular bacterium) constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a number of shapes, ranging from spheres to rods and spirals. Bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep portions of Earth's crust. Bacteria also live in symbiotic and parasitic relationships with plants and animals., Monkeypox is an infectious disease caused by the monkeypox virus. The disease was first identified in laboratory monkeys, hence its name, but in its natural state it seems to infect rodents more often than primates. The disease is indigenous to Central and West Africa. An outbreak that occurred in the United States in 2003 was traced to a pet store where imported Gambian pouched rats were sold., Cowpox is an infectious disease caused by the cowpox virus. The virus, part of the orthopoxvirus family, is closely related to the "vaccinia" virus. The virus is zoonotic, meaning that it is transferable between species, such as from animal to human. The transferral of the disease was first observed in dairymaids who touched the udders of infected cows and consequently developed the signature pustules on their hands. Cowpox is more commonly found in animals other than bovines, such as rodents. Cowpox is similar to, but much milder than, the highly contagious and often deadly smallpox disease. Its close resemblance to the mild form of smallpox and the observation that dairymaids were immune from smallpox inspired the first smallpox vaccine, created and administered by English physician Edward Jenner., In biology, an organism is any contiguous living system, such as an animal, plant, fungus, archaeon, or bacterium. All known types of organisms are capable of some degree of response to stimuli, reproduction, growth and development and homeostasis. An organism consists of one or more cells; when it has one cell it is known as a unicellular organism; and when it has more than one it is known as a multicellular organism. Most unicellular organisms are of microscopic scale and are thus loosely described as microorganisms. Humans are multicellular organisms composed of many trillions of cells grouped into specialized tissues and organs., Buffalopox is caused by buffalopox virus ( BPXV ) ; it is a Poxviridae for which the natural host is buffalo . It mainly infects buffalo but has been known to infect cows and humans . It is classified in the Orthopoxvirus ( OPV ) genus and the subfamily Chordopoxvirinae . The appearance of buffalopox follows a pattern and is described as emerging and re-emerging , it commonly occurs in sporadic and epidemic forms in domestic and commercial farm settings ., Subject: buffalopox, Relation: parent_taxon, Options: (A) animal (B) archaea (C) bacteria (D) chordata (E) chordopoxvirinae (F) fungi (G) human (H) metazoa (I) orthopoxvirus (J) poxviridae (K) primates (L) vaccinia virus (M) variola (N) vertebrata (O) virus
Output: vaccinia virus