Context: Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells., A nutrient is a component in foods that an organism uses to survive and grow. Macronutrients provide the bulk energy an organism's metabolic system needs to function while micronutrients provide the necessary cofactors for metabolism to be carried out. Both types of nutrients can be acquired from the environment. Micronutrients are used to build and repair tissues and to regulate body processes while macronutrients are converted to, and used for, energy. Methods of nutrient intake are different for plants and animals. Plants take in nutrients directly from the soil through their roots and from the atmosphere through their leaves. Animals and protists have specialized digestive systems that work to break down macronutrients for energy and utilize micronutrients for both metabolism and anabolism (constructive synthesis) in the body., Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Even when a blood vessel is not injured, blood clots may form in the body under certain conditions. A clot, or a piece of the clot, that breaks free and begins to travel around the body is known as an embolus. , In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus. It comprises cytosol (the gel-like substance enclosed within the cell membrane) and the organelles  the cell's internal sub-structures. All of the contents of the cells of prokaryote organisms (such as bacteria, which lack a cell nucleus) are contained within the cytoplasm. Within the cells of eukaryote organisms the contents of the cell nucleus are separated from the cytoplasm, and are then called the nucleoplasm. The cytoplasm is about 80% water and usually colorless., Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen which causes it to polymerize. The polymerized fibrin together with platelets forms a hemostatic plug or clot over a wound site., Prostacyclin (also called prostaglandin I2 or PGI) is a prostaglandin member of the eicosanoid family of lipid molecules. It inhibits platelet activation and is also an effective vasodilator., The liver is a vital organ of vertebrates and some other animals. In the human, it is located in the upper right quadrant of the abdomen, below the diaphragm. The liver has a wide range of functions, including detoxification of various metabolites, protein synthesis, and the production of biochemicals necessary for digestion., Metabolic wastes or excretes are substances left over from metabolic processes (such as cellular respiration), which cannot be used by the organism (they are surplus or toxic), and must therefore be excreted. This includes nitrogen compounds, water, CO, phosphates, sulfates, etc. Animals treat these compounds as excretes. Plants have chemical "machinery" which transforms some of them (primarily the nitrogen compounds) into useful substances, and it has been shown by Brian J. Ford that abscissa leaves also carry wastes away from the parent plant. In this way, Ford argues that the shed leaf acts as an "excretory" (an organ carrying away excretory products)., Oxygen is a chemical element with symbol O and atomic number 8. It is a member of the chalcogen group on the periodic table and is a highly reactive nonmetal and oxidizing agent that readily forms oxides with most elements as well as other compounds. By mass, oxygen is the third-most abundant element in the universe, after hydrogen and helium. At standard temperature and pressure, two atoms of the element bind to form dioxygen, a colorless and odorless diatomic gas with the formula . This is an important part of the atmosphere and diatomic oxygen gas constitutes 20.8% of the Earth's atmosphere. Additionally, as oxides the element makes up almost half of the Earth's crust., Bone marrow is the flexible tissue in the interior of bones. In humans, red blood cells are produced by cores of bone marrow in the heads of long bones in a process known as hematopoiesis.<ref name="Birbrair n/an/a"></ref> On average, bone marrow constitutes 4% of the total body mass of humans; in an adult having 65 kilograms of mass (143 lbs), bone marrow typically accounts for approximately . The hematopoietic component of bone marrow produces approximately 500 billion blood cells per day, which use the bone marrow vasculature as a conduit to the body's systemic circulation. Bone marrow is also a key component of the lymphatic system, producing the lymphocytes that support the body's immune system., In cell biology, the nucleus (pl. "nuclei"; from Latin or , meaning "kernel" or "seed") is a membrane-enclosed organelle found in eukaryotic cells. Eukaryotes usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others have many., Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset., Thrombin ("fibrinogenase", "thrombase", "thrombofort", "topical", "thrombin-C", "tropostasin", "activated blood-coagulation factor II", "blood-coagulation factor IIa", "factor IIa", "E thrombin", "beta-thrombin", "gamma-thrombin") is a serine protease, an enzyme that, in humans, is encoded by the "F2" gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions., An embolus (plural emboli; from the Greek  "wedge", "plug") is an unattached mass that travels through the bloodstream and is capable of clogging arterial capillary beds (create an arterial occlusion) at a site distant from its point of origin. There are a number of different types of emboli, including blood clots, cholesterol plaque or crystals, fat globules, gas bubbles, and foreign bodies., Von Willebrand factor (vWF) is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome. Increased plasma levels in a large number of cardiovascular, neoplastic, and connective tissue diseases are presumed to arise from adverse changes to the endothelium, and may contribute to an increased risk of thrombosis., The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis. The study of the blood flow is called hemodynamics. The study of the properties of the blood flow is called hemorheology., Nitric oxide (nitrogen oxide, nitrogen monoxide) is a molecular, chemical compound with chemical formula of ·NO. One of several oxides of nitrogen, it is a colorless gas under standard conditions. Nitric oxide is a free radicali.e., its bonding structure includes an unpaired electron, represented by the dot (·) on the nitrogen atomand it is in the class of heteronuclear diatomic molecules that are of historic theoretical interest (for the insights they gave in formulating early modern theories of bonding). It is a particularly important intermediate in the chemical industry. In addition, some is unavoidably produced during combustion of fossil fuels in power plants and automobile engines, with excess being created when more air or higher temperatures are present than needed for efficient and complete combustion of the fuel. It is also produced naturally by the extremely high air temperatures produced along the path of lightning in thunderstorms., Wound healing is the process by which skin or other body tissue repairs itself after trauma. In undamaged skin, the epidermis (surface layer) and dermis (deeper layer) form a protective barrier against the external environment. When the barrier is broken, an orchestrated cascade of biochemical events is set into motion to repair the damage. This process is divided into predictable phases: blood clotting (hemostasis), inflammation, tissue growth (proliferation) and tissue remodeling (maturation). Blood clotting may be considered to be part of the inflammation stage instead of a separate stage., Coagulation ( also known as clotting ) is the process by which blood changes from a liquid to a gel , forming a clot . It potentially results in hemostasis , the cessation of blood loss from a damaged vessel , followed by repair . The mechanism of coagulation involves activation , adhesion , and aggregation of platelets along with deposition and maturation of fibrin . Disorders of coagulation are disease states which can result in bleeding ( hemorrhage or bruising ) or obstructive clotting ( thrombosis ) . Coagulation is highly conserved throughout biology ; in all mammals , coagulation involves both a cellular ( platelet ) and a protein ( coagulation factor ) component . The system in humans has been the most extensively researched and is the best understood . Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel . Exposure of blood to the space under the endothelium initiates two processes : changes in platelets , and the exposure of subendothilial tissue factor to plasma Factor VII , which ultimately leads to fibrin formation . Platelets immediately form a plug at the site of injury ; this is called primary hemostasis . Secondary hemostasis occurs simultaneously : Additional coagulation factors or clotting factors beyond Factor VII ( listed below ) respond in a complex cascade to form fibrin strands , which strengthen the platelet plug ., Hemostasis or haemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage). It is the first stage of wound healing. This involves coagulation, blood changing from a liquid to a gel. Intact blood vessels are central to moderating blood's tendency to form clots. The endothelial cells of intact vessels prevent blood clotting with a heparin-like molecule and thrombomodulin and prevent platelet aggregation with nitric oxide and prostacyclin. When endothelial injury occurs, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor which initiate the maintenance of hemostasis after injury. Hemostasis has three major steps: 1) vasoconstriction, 2) temporary blockage of a break by a platelet plug, and 3) blood coagulation, or formation of a fibrin clot. These processes seal the hole until tissues are repaired., Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Å. The length of the dried molecule is 475 ± 25 Å., Bleeding, also known as hemorrhaging or haemorrhaging, is blood escaping from the circulatory system. Bleeding can occur internally, where blood leaks from blood vessels inside the body, or externally, either through a natural opening such as the mouth, nose, ear, urethra, vagina or anus, or through a break in the skin.
Hypovolemia is a massive decrease in blood volume, and death by excessive loss of blood is referred to as exsanguination. Typically, a healthy person can endure a loss of 1015% of the total blood volume without serious medical difficulties (by comparison, blood donation typically takes 810% of the donor's blood volume). The stopping or controlling of bleeding is called hemostasis and is an important part of both first aid and surgery., Proteins (or ) are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity., Body fluid, bodily fluids or biofluids are liquids originating from inside the bodies of living people. They include fluids that are excreted or secreted from the body, and body water that normally is not., The blood vessels are the part of the circulatory system that transports blood throughout the human body. There are three major types of blood vessels: the arteries, which carry the blood away from the heart; the capillaries, which enable the actual exchange of water and chemicals between the blood and the tissues; and the veins, which carry blood from the capillaries back toward the heart. The word "vascular", meaning relating to the blood vessels, is derived from the Latin "vas", meaning vessel. A few structures (such as cartilage and the lens of the eye) do not contain blood vessels and are labeled., A megakaryocyte ("mega-" + "karyo-" + "-cyte", "large-nucleus cell") is a large bone marrow cell with a lobulated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting. Megakaryocytes normally account for 1 out of 10,000 bone marrow cells but can increase in number nearly 10-fold during the course of certain diseases. Owing to variations in combining forms and spelling, synonyms include megalokaryocyte and megacaryocyte., Platelets, also called thrombocytes (thromb- + -cyte, "blood clot cell"), are a component of blood whose function (along with the coagulation factors) is to stop bleeding by clumping and clotting blood vessel injuries. Platelets have no cell nucleus: they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow, and then enter the circulation. These unactivated platelets are biconvex discoid (lens-shaped) structures, 23 µm in greatest diameter. Platelets are found only in mammals, whereas in other animals (e.g. birds, amphibians) thrombocytes circulate as intact mononuclear cells., Subject: coagulation, Relation: part_of, Options: (A) abdomen (B) account (C) animals (D) atom (E) bind (F) biology (G) body (H) bones (I) c (J) cell (K) center (L) chemical industry (M) circulatory system (N) class (O) day (P) disease (Q) dna (R) earth (S) epidermis (T) family (U) gas (V) gene (W) human (X) industry (Y) liquid (Z) liver ([) mass (\) name (]) nucleus (^) organism (_) part (`) periodic table (a) person (b) plasma (c) process (d) stage (e) system (f) transport (g) universe (h) word (i) wound healing
Output: wound healing