Context: Immunology is a branch of biology that covers the study of immune systems in all organisms. It was the Russian biologist Ilya Ilyich Mechnikov who boosted studies on immunology, and received the Nobel Prize in 1908 for his work. He jabbed the thorn of a rose on a starfish and noted that, 24 hours later, cells were surrounding the tip. It was an active response of the body, trying to maintain its integrity. It was Mechnikov who first observed the phenomenon of phagocytosis, in which the body defends itself against a foreign body, and coined the term. It charts, measures, and contextualizes the: physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system "in vitro", "in situ," and "in vivo". Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, virology, bacteriology, parasitology, psychiatry, and dermatology., The Czech Republic, also known by the short name Czechia, is a nation state in Central Europe bordered by Germany to the west, Austria to the south, Slovakia to the east and Poland to the northeast. The Czech Republic covers an area of with mostly temperate continental climate and oceanic climate. It is a unitary parliamentary republic, has 10.5 million inhabitants and the capital and largest city is Prague, with over 1.2 million residents. The Czech Republic includes the historical territories of Bohemia, Moravia, and Czech Silesia., In biology, a species (abbreviated sp., with the plural form species abbreviated spp.) is the basic unit of biological classification and a taxonomic rank. A species is often defined as the largest group of organisms in which two individuals can produce fertile offspring, typically by sexual reproduction. While this definition is often adequate, looked at more closely it is often problematic. For example, in a species complex, the boundaries between closely related species become unclear or disappear altogether. Other ways of defining species include similarity of DNA, morphology, or ecological niche. The presence of locally adaptive traits may further subdivide species into infraspecific taxa such as subspecies., Biology is a natural science concerned with the study of life and living organisms, including their structure, function, growth, evolution, distribution, identification and taxonomy. Modern biology is a vast and eclectic field, composed of many branches and subdisciplines. However, despite the broad scope of biology, there are certain general and unifying concepts within it that govern all study and research, consolidating it into single, coherent field. In general, biology recognizes the cell as the basic unit of life, genes as the basic unit of heredity, and evolution as the engine that propels the synthesis and creation of new species. It is also understood today that all the organisms survive by consuming and transforming energy and by regulating their internal environment to maintain a stable and vital condition known as homeostasis., Evolution is change in the heritable characteristics of biological populations over successive generations. Evolutionary processes give rise to biodiversity at every level of biological organisation, including the levels of species, individual organisms, and molecules., Heredity is the genetic information passing for traits from parents to their offspring, either through asexual reproduction or sexual reproduction. This is the process by which an offspring cell or organism acquires or becomes predisposed to the characteristics of its parent cell or organism. Through heredity, variations exhibited by individuals can accumulate and cause some species to evolve through the natural selection of specific phenotype traits. The study of heredity in biology is called genetics, which includes the field of epigenetics., Genetics is the study of genes, genetic variation, and heredity in living organisms. It is generally considered a field of biology, but intersects frequently with many other life sciences and is strongly linked with the study of information systems., Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes. RNA and DNA are nucleic acids, and, along with proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life. Like DNA, RNA is assembled as a chain of nucleotides, but unlike DNA it is more often found in nature as a single-strand folded onto itself, rather than a paired double-strand. Cellular organisms use messenger RNA (mRNA) to convey genetic information (using the letters G, U, A, and C to denote the nitrogenous bases guanine, uracil, adenine, and cytosine) that directs synthesis of specific proteins. Many viruses encode their genetic information using an RNA genome., Metamorphosis is a biological process by which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's body structure through cell growth and differentiation. Some insects, fishes, amphibians, mollusks, crustaceans, cnidarians, echinoderms and tunicates undergo metamorphosis, which is often accompanied by a change of nutrition source or behavior. Animals that goes through metamorphosis are called metamorphoses. Animals can be divided into species that undergo complete metamorphosis ("holometaboly"), incomplete metamorphosis ("hemimetaboly"), or no metamorphosis ("ametaboly")., Homeostasis or homoeostasis is the property of a system in which a variable (for example, the concentration of a substance in solution, or its temperature) is actively regulated to remain very nearly constant. This regulation occurs inside a defined environment (mostly within a living organism's body). Examples of homeostasis include the regulation of the body temperature of an animal, the pH of its extracellular fluids, or the concentrations of sodium (Na) and calcium (Ca) ions or of glucose in the blood plasma, despite changes in the animals environment, or what it has eaten, or what it is doing (for example, resting or exercising). Each of these variables is controlled by a separate homeostat (or regulator), which, together, maintain life. Homeostats are energy-consuming physiological mechanisms., Molecular biology concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, and proteins and their biosynthesis, as well as the regulation of these interactions. Writing in "Nature" in 1961, William Astbury described molecular biology as:, Europe is a continent that comprises the westernmost part of Eurasia. Europe is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, and the Mediterranean Sea to the south. To the east and southeast, Europe is generally considered as separated from Asia by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways of the Turkish Straits. Yet the non-oceanic borders of Europea concept dating back to classical antiquityare arbitrary. The primarily physiographic term "continent" as applied to Europe also incorporates cultural and political elements whose discontinuities are not always reflected by the continent's current overland boundaries., The Max Planck Institute of Molecular Cell Biology and Genetics ( MPI - CBG ) is a biology research institute located in Dresden , Germany . It was founded in 1998 and was fully operational in 2000 . 24 research groups work in molecular biology , cell biology , and developmental biology , supported by various facilities ., Munich (also in British English ) is the capital and largest city of the German state of Bavaria, on the banks of River Isar north of the Bavarian Alps. Munich is the third largest city in Germany, after Berlin and Hamburg, and the 12th biggest city of the European Union, with a population of above 1.5 million. The Munich Metropolitan Region is home to 5.8 million people., Berlin is the capital and the largest city of Germany as well as one of its constituent 16 states. With a population of approximately 3.5 million people, Berlin is the second most populous city proper and the seventh most populous urban area in the European Union. Located in northeastern Germany on the banks of rivers Spree and Havel, it is the centre of the Berlin-Brandenburg Metropolitan Region, which has about 6 million residents from more than 180 nations. Due to its location in the European Plain, Berlin is influenced by a temperate seasonal climate. Around one-third of the city's area is composed of forests, parks, gardens, rivers and lakes., William Thomas Astbury FRS (also Bill Astbury; 25 February 1898, Longton  4 June 1961, Leeds) was an English physicist and molecular biologist who made pioneering X-ray diffraction studies of biological molecules. His work on keratin provided the foundation for Linus Pauling's discovery of the alpha helix. He also studied the structure for DNA in 1937 and made the first step in the elucidation of its structure., Hamburg (local pronunciation ; Low German/Low Saxon: "Hamborg" ), officially "Freie und Hansestadt Hamburg" (Free and Hanseatic City of Hamburg), is the second largest city in Germany and the eighth largest city in the European Union. It is the second smallest German state by area. Its population is over 1.7 million people, and the wider Hamburg Metropolitan Region covers more than 5.1 million inhabitants. The city is situated on the river Elbe., Frankfurt am Main is a metropolis and the largest city in the German state of Hesse and the fifth-largest city in Germany, with a 2015 population of 731,095 within its administrative boundaries, and 2.3 million in its urban area. The city is at the centre of the larger Frankfurt Rhine-Main Metropolitan Region, which has a population of 5.8 million and is Germany's second-largest metropolitan region after Rhine-Ruhr. Since the enlargement of the European Union in 2013, the geographic centre of the EU is about to the east of Frankfurt's CBD, the Bankenviertel. Frankfurt is culturally and ethnically diverse, with around half of the population, and a majority of young people, having a migration background. A quarter of the population are foreign nationals, including many expatriates., Deoxyribonucleic acid (DNA) is a molecule that carries the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. DNA and RNA are nucleic acids; alongside proteins, lipids and complex carbohydrates (polysaccharides), they are one of the four major types of macromolecules that are essential for all known forms of life. Most DNA molecules consist of two biopolymer strands coiled around each other to form a double helix., Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.
Tobacco use is the cause of about 22% of cancer deaths. Another 10% is due to obesity, poor diet, lack of physical activity and drinking alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In the developing world nearly 20% of cancers are due to infections such as hepatitis B, hepatitis C and human papillomavirus (HPV). These factors act, at least partly, by changing the genes of a cell. Typically many genetic changes are required before cancer develops. Approximately 510% of cancers are due to inherited genetic defects from a person's parents. Cancer can be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy.
Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. Early detection through screening is useful for cervical and colorectal cancer. The benefits of screening in breast cancer are controversial. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy, and targeted therapy. Pain and symptom management are an important part of care. Palliative care is particularly important in people with advanced disease. The chance of survival depends on the type of cancer and extent of disease at the start of treatment. In children under 15 at diagnosis the five-year survival rate in the developed world is on average 80%. For cancer in the United States the average five-year survival rate is 66%.
In 2012 about 14.1 million new cases of cancer occurred globally (not including skin cancer other than melanoma). It caused about 8.2 million deaths or 14.6% of human deaths. The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. If skin cancer other than melanoma were included in total new cancers each year it would account for around 40% of cases. In children, acute lymphoblastic leukaemia and brain tumors are most common except in Africa where non-Hodgkin lymphoma occurs more often. In 2012, about 165,000 children under 15 years of age were diagnosed with cancer. The risk of cancer increases significantly with age and many cancers occur more commonly in developed countries. Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world. The financial costs of cancer were estimated at $1.16 trillion US dollars per year as of 2010.
Definitions.
Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely., The European Union (EU) is a political and economic union of member states that are located primarily in Europe. It has an area of , and an estimated population of over 510 million. The EU has developed an internal single market through a standardised system of laws that apply in all member states. EU policies aim to ensure the free movement of people, goods, services, and capital within the internal market, enact legislation in justice and home affairs, and maintain common policies on trade, agriculture, fisheries, and regional development. Within the Schengen Area, passport controls have been abolished. A monetary union was established in 1999 and came into full force in 2002, and is composed of 19 EU member states which use the euro currency., Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction and metamorphosis and in the growth and differentiation of stem cells in the adult organism., In physics, energy is the property that must be transferred to an object in order to perform work on  or to heat  the object, and can be converted in form, but not created or destroyed. The SI unit of energy is the joule, which is the energy transferred to an object by the mechanical work of moving it a distance of 1 metre against a force of 1 newton., Stuttgart ( Swabian: "Schduagert"), often nicknamed the ""Schwabenmetropole"" in reference to its location in the center of Swabia and the local dialect spoken by some natives, is the capital and largest city of the German state of Baden-Württemberg. It is located on the Neckar river in a fertile valley locally known as the "Stuttgarter Kessel" an hour from the Swabian Jura and the Black Forest. Stuttgart's name comes from the Old High German word ""Stuogarten"," or "stud farm"  a reference to the city's founding in 950 AD as a stud farm. Stuttgarts urban area has a population of 623,738, and a further making it the sixth largest city in Germany, 2.7 million people live in the citys administrative region, and another 5.3 million people in its metropolitan area, making it the fourth largest metropolitan area in Germany., A biomolecule or biological molecule is molecule that is present in living organisms, including large macromolecules such as proteins, carbohydrates, lipids, and nucleic acids, as well as small molecules such as primary metabolites, secondary metabolites, and natural products. A more general name for this class of material is biological materials. Biomolecules are usually endogenous but may also be exogenous. For example, pharmaceutical drugs may be natural products or semisynthetic (biopharmaceuticals) or they may be totally synthetic., Leipzig is the largest city in the federal state of Saxony, Germany. With a population of 570,087 inhabitants (1,001,220 residents in the larger urban zone) it is Germany's tenth most populous city. Leipzig is located about southwest of Berlin at the confluence of the White Elster, Pleisse and Parthe rivers at the southern end of the North German Plain., The Free State of Saxony is a landlocked federal state of Germany, bordering the federal states of Brandenburg, Saxony Anhalt, Thuringia, and Bavaria, as well as the countries of Poland (Lower Silesian and Lubusz Voivodeships) and the Czech Republic (Karlovy Vary, Liberec and Ústí nad Labem Regions). Its capital is Dresden, and its largest city is Leipzig., A republic (from ) is a sovereign state, country, or government which is organized with a form of government in which power resides in elected individuals representing the citizen body and government leaders exercise power according to the rule of law. In modern times, the definition of a republic commonly refers to a government which excludes a monarch. Currently, 147 of the world's 206 sovereign states use the word "republic" as part of their official names; not all of these are republics in the sense of having elected governments, nor do all nations with elected governments use the word "republic" in their names., Dresden is the capital city and after Leipzig the second-largest city of the Free State of Saxony in Germany. It is situated in a valley on the River Elbe, near the border with the Czech Republic., A gene is a locus (or region) of DNA which is made up of nucleotides and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as geneenvironment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life., Cell biology (formerly called cytology, from the Greek , "kytos", "vessel") is a branch of biology that studies the different structures and functions of the cell and focuses mainly on the idea of the cell as the basic unit of life. Cell biology explains the structure, organization of the organelles they contain, their physiological properties, metabolic processes, signaling pathways , life cycle, and interactions with their environment. This is done both on a microscopic and molecular level as it encompasses prokaryotic cells and eukaryotic cells. Knowing the components of cells and how cells work is fundamental to all biological sciences; it is also essential for research in bio-medical fields such as cancer, and other diseases. Research in cell biology is closely related to genetics, biochemistry, molecular biology, immunology, and developmental biology., The Elbe (; Low German: "Elv") is one of the major rivers of Central Europe. It rises in the Krkonoše Mountains of the northern Czech Republic before traversing much of Bohemia (Czech Republic), then Germany and flowing into the North Sea at Cuxhaven, northwest of Hamburg. Its total length is ., Natural science is a branch of science concerned with the description, prediction, and understanding of natural phenomena, based on observational and empirical evidence. Mechanisms such as peer review and repeatability of findings are used to try to ensure the validity of scientific advances., In biology, an organism is any contiguous living system, such as an animal, plant, fungus, archaeon, or bacterium. All known types of organisms are capable of some degree of response to stimuli, reproduction, growth and development and homeostasis. An organism consists of one or more cells; when it has one cell it is known as a unicellular organism; and when it has more than one it is known as a multicellular organism. Most unicellular organisms are of microscopic scale and are thus loosely described as microorganisms. Humans are multicellular organisms composed of many trillions of cells grouped into specialized tissues and organs., Cologne is the largest city in the German federal State of North Rhine-Westphalia and the fourth-largest city in Germany (after Berlin, Hamburg, and Munich). It is located within the Rhine-Ruhr metropolitan region, one of the major European metropolitan regions and the largest in Germany, with more than ten million inhabitants., Life is a characteristic distinguishing physical entities having biological processes, such as signaling and self-sustaining processes, from those that do not, either because such functions have ceased, or because they never had such functions and are classified as inanimate. Various forms of life exist, such as plants, animals, fungi, protists, archaea, and bacteria. The criteria can at times be ambiguous and may or may not define viruses, viroids, or potential artificial life as "living". Biology is the primary science concerned with the study of life, although many other sciences are involved., Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms. By controlling information flow through biochemical signaling and the flow of chemical energy through metabolism, biochemical processes give rise to the complexity of life. Over the last decades of the 20th century, biochemistry has become so successful at explaining living processes that now almost all areas of the life sciences from botany to medicine to genetics are engaged in biochemical research. Today, the main focus of pure biochemistry is on understanding how biological molecules give rise to the processes that occur within living cells, which in turn relates greatly to the study and understanding of tissues, organs, and whole organismsthat is, all of biology., Proteins (or ) are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity., Düsseldorf (Low Franconian, Ripuarian: "Düsseldörp" ) is the capital city of the German state of North Rhine-Westphalia and the seventh most populous city in Germany. Düsseldorf is an international business and financial centre, renowned for its fashion and trade fairs. The city is headquarters to one Fortune Global 500 and two DAX companies. Messe Düsseldorf organises nearly one fifth of premier trade shows., A parliamentary republic is a republic that operates under a parliamentary system of government where the executive branch (the government) derives its legitimacy from and is accountable to the legislature (the parliament). There are a number of variations of parliamentary republics. Most have a clear differentiation between the head of government and the head of state, with the head of government holding real power, much like constitutional monarchies. Some have combined the roles of head of state and head of government, much like presidential systems, but with a dependency upon parliamentary power., The euro (sign: €; code: EUR) is the official currency of the eurozone, which consists of 19 of the member states of the European Union: Austria, Belgium, Cyprus, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Portugal, Slovakia, Slovenia, and Spain. The currency is also officially used by the institutions of the European Union and four other European countries, as well as unilaterally by two others, and is consequently used daily by some 337 million Europeans . Outside of Europe, a number of overseas territories of EU members also use the euro as their currency., Germany, officially the Federal Republic of Germany, is a federal parliamentary republic in central-western Europe. It includes 16 constituent states, covers an area of , and has a largely temperate seasonal climate. With about 82 million inhabitants, Germany is the most populous member state of the European Union. After the United States, it is the second most popular immigration destination in the world. Germany's capital and largest metropolis is Berlin. Other major cities include Hamburg, Munich, Cologne, Frankfurt, Stuttgart and Düsseldorf., Subject: max planck institute of molecular cell biology and genetics, Relation: located_in_the_administrative_territorial_entity, Options: (A) africa (B) atlantic ocean (C) austria (D) banks (E) bavaria (F) belgium (G) berlin (H) center (I) central (J) cologne (K) cyprus (L) czech republic (M) dax (N) dresden (O) düsseldorf (P) east (Q) estonia (R) europe (S) european union (T) finland (U) frankfurt (V) free state (W) germany (X) goes (Y) hamburg (Z) hesse ([) italy (\) leeds (]) leipzig (^) liberec (_) munich (`) netherlands (a) newton (b) northwest (c) of (d) portugal (e) prague (f) rhine (g) rise (h) river (i) saxony (j) schengen (k) si (l) slovakia (m) south (n) strand (o) stuttgart (p) thuringia
Output: saxony