niryuu/sni-each-converted huggingface dataset:
as well as possible approaches of utilization of abovementioned phenomenon for struggling against viral infections.
Output: purpose
In this study , a multi-pathogens survey was conducted to verify the sanitary status of two Italian wolf packs of Majella National Park.
Output: purpose
Methods : Proteome and histone lysine acetylation were profiled through stable isotope labeling for cell culture ( SILAC ) - based quantitative proteomics.
Output: method
we examine the impact of interventions on clinical attack rates rather than mortality.
Output: method
the bacterial pathogen Francisella tularensis proliferates within the cytosol of macrophages without demonstrable control by autophagy.
Output: background
Moreover , nsp3 and E protein colocalized during the infection.
Output: finding
Saudi Arabia , over an almost 2-year period and local Arabian camels over 2 months in the year after surveillance of the port.
Output: method
software architecture and implementation of HealthMap and discusses key challenges and future plans.
Output: method
The current COVID-19 pandemic is rapidly spreading around the world.
Output: background
This paper reviews the biochemistry of ACE2 and discusses key findings such as the elucidation of crystal structures for ACE2 and testicular ACE and the development of ACE2 inhibitors that have now provided a basis for future research on this enzyme.
Output: purpose
Here , we highlight the most important hosttargeting strategies against hepatitis C and critically discuss their opportunities and risks.
Output: purpose
incidence and clinical features of PIV-associated infections diagnosed during the hospital stay of patients admitted to pediatric intensive care unit ( PICU ) and intensive care unit ( ICU ) of 5 medical centers across Kuwait.
Output: purpose
A major advantage of DNA vaccination is the ability to induce both humoral and cellular immune responses.
Output: background
Serum was analyzed for BCoV antibodies.
Output: method
For Case 2 , the most likely source could not be determined.
Output: finding
and 4 % administered aerosolized medication.
Output: finding
not only after nuclear disasters but also in other circumstances.
Output: finding
the oxygenation index and C-reactive protein ( CRP ) levels in patients with severe pneumonia.
Output: purpose
Objectives : To investigate the detection rates of bovine coronavirus ( BCoV ) in feces of healthy and diarrheic calves and to describe the usefulness of a pancoronavirus reverse transcriptase ( RT ) PCR ( PanCoV-RT-PCR ) assay to identify BCoV in samples of diarrheic calves.
Output: purpose
and therefore , might represent more reliable indicators of disease activity in future outbreaks.
Output: finding
Aim : To compare the performances of molecular and non-molecular tests to diagnose respiratory viral infections and to evaluate the pros and contras of each technique.
Output: purpose
In the present study , we performed a clinical study to apply our TCI formulation for vaccination against tetanus and diphtheria in human.
Output: purpose
The experiment was conducted for two main scenarios ; human-computer interaction scenario and health monitoring scenario.
Output: method
Results : Median age of patients was 12 months.
Output: finding
suggesting that the interaction between nsp3 and E protein may play a role in the E protein ubiquitination status and therefore on its turnover.
Output: finding
exhibiting no noticeable morphological changes.
Output: finding
The rates of fall-related attendance have been increasing and still remain high.
Output: finding
Blue and red boxes indicate positions of those putative elements and related transcription factors predicted by GPMiner.
Output: finding
A B S T R A C T Interferons ( IFN ) are key cytokines with multifaceted antiviral and cell-modulatory properties.
Output: background
and discuss current and future possibilities in using these routes as a means to improve therapeutic delivery.
Output: purpose
The aim of this study was to identify the CPV-2 subtypes detected in diagnostic specimens and rule out occult shedding of CPV-2 vaccine strains.
Output: purpose
lectin-glycan recognition , pathogen-host interactions and hierarchical signaling cascades.
Output: purpose
There is still no vaccine or definitive treatment for this virus because its pathogenesis and proliferation pathways are still unknown.
Output: background
HIV-1 Tat protein is an important pathogenic factor in HIV-1-associated neurological diseases.
Output: background
the nucleotide sequence of the 5 ' - unique regions of mRNAs 4 and 5 were determined from cloned cDNAs.
Output: background
Airport screening is unlikely to detect a sufficient proportion of 2019-nCoV infected travellers to avoid entry of infected travellers.
Output: background
This concept has been verified recently in a pilot study with human cells which had been rendered transgenomic for a 5.6 kbp bacterial plasmid.
Output: finding
Sequence analysis showed some viruses to be related to IBV.
Output: finding
and their eff ect on childhood asthma.
Output: purpose
R 0 , is the number of secondary infections which one infected indi-102 vidual would produce in a entirely susceptible population.
Output: method
However , the possible transmission of SARS-CoV-2 by conjunctiva is controversial.
Output: background
Three-dimensional analyses indicated that half of the originally discovered 1,7-DAAC structure superimposed well with 4-amino-7-chloroquinolinebased antimalarial agents.
Output: background
Here we study the impact of human mobility on HIV transmission in different parts of Kenya.
Output: purpose
both theoretical and managerial applicability of the proposed stage-based model are empirically verified in this study.
Output: method
Methods : We calculated the time lag and correlation between ILI incidence ( from ILI sentinel surveillance , based on general practitioners ( GP ) consultations ) and percentages of ICU admissions with a respiratory infection ( from the Dutch National Intensive Care Registry ) over the years 2003-2011.
Output: method
All persons who could taste the commercial solution could taste homemade solution.
Output: finding
Nicaragua ( 192 ) and Peru ( 191 ) were tested.
Output: finding
We examined the CoVs circulating among wild birds in Finland.
Output: purpose
IgHCDR3 regions were defined with their Kabat numbering using the software available on the Abnum website ( http://www.bioinf.org.uk/abs/abnum/ ).
Output: method
variations were only observed in the levels of specific IgY which depended rather on the age of ducks at the time of infection than on the infectious dose.
Output: finding
is an emerging swine enteropathogenic coronavirus ( CoV ).
Output: background
Objectives : To describe the epidemiology and etiologies of respiratory illnesses among pilgrims returning to Jordan after the 2014 Hajj.
Output: purpose
parental atopic illnesses , and parental smoking.
Output: method
for the detection of 14 respiratory viruses.
Output: method
lethal respiratory disease occurring across several countries in the Middle East.
Output: background
and the data collection ended on March 17 2020.
Output: method
Data were collected from 25 th January to 28 th February 2020.
Output: method
leaving the axons denuded , and at the same time astrocyte endfeet at the glial limiting membrane were swollen and partly destroyed.
Output: background
Therefore , there is a need for the development of a rapid and sensitive diagnosis of respiratory viral pathogens.
Output: purpose
were deemed controlled if transmission ended within 12 weeks or before 5000 cases in total.
Output: method
successful and unsuccessful of such a journey.
Output: purpose
the receptor for Deltacoronavirus is unclear.
Output: background
The propagation of a mouse-adapted strain ( 67N ) of haemagglutinating encephalomyelitis virus in infected mice and murine cells was examined by viral re-isolation and immunostaining.
Output: method
Pentoxifylline was able to inhibit JEV replication in a dose-dependent manner at a 50 % inhibitory concentration ( IC 50 ) of 50.3 g/mL ( 0.00018 M ) and a therapeutic index ( TI ) of 10.
Output: finding
3943 ( 90.3 % ) of whom were assigned a travel-related diagnosis.
Output: method
A cross-sectional study was conducted among paediatric patients aged 2-13 years with dengue in Yankin Children Hospital , Myanmar.
Output: method
Objective : To survey fertility patients ' agreement with ASRM recommendations during the pandemic and the emotional impact on them.
Output: purpose
phylogeny and antibody titres against parvoviruses were investigated in the positive cats.
Output: method
It has been shown that autophagy interacts with both adaptive and innate immunity.
Output: background
We therefore evaluated the effects of PTH on improving the effects of CD in Early-Stage SAON.
Output: purpose
Databases and computational tools for mimotopes have been an important part of phage display study.
Output: background
were better remembered and retained in the participants ' memory.
Output: finding
As examples , cellular syntheses of dimers of ( GB1 ) 2 ( where GB1 stands for immunoglobulin-binding domain B1 of streptococcal protein G ) and of four-arm elastin-like star proteins were demonstrated.
Output: background
Here , we identify the essential cytokinetic formin Cdc12 as a key CR substrate of SIN kinase Sid2.
Output: purpose
to our knowledge , of SARS in a naval diver.
Output: purpose
multi-resistant Gram-negative pathogens , mycobacteria or respiratory viruses may be involved.
Output: finding
most viruses require the modification of their tropism to specifically enter and replicate in such cells.
Output: background
the novelty of our approach is the inclusion of fuzzy integral with Markov chain for sequence analysis in the alignment-free model.
Output: purpose
We sought to characterize the relationship of the translated proteins of 2019-nCoV with other species of Orthocoronavirinae.
Output: purpose
and the advantages of pulmonary vaccination are discussed.
Output: method
Installation of protective shields on slit lamps were implemented and surgical masks were worn by both ophthalmologists and patients.
Output: method
We then compared bioactivities of these two recombinant proteins.
Output: method
Association between BCoV and health status was evaluated by exact and random effect logistic regression.
Output: method
and since there are now a number of high resolution x-ray structures of SARS-CoV 3CLpro available making structure-based drug-design possible.
Output: background
No medications were associated with an increase or decrease the likelihood of the infection.
Output: finding
Logistic regression was used to assess the risk of MERS-CoV infection among the suspected cases.
Output: method
removal or deactivation of the catalyst will convert the DCL into a static mixture.
Output: finding
This animal model has the potential to recapitulate the potential neuropathogenicity of SAFV-3.
Output: finding
We report the development of RT-PCR tests that distinguish live FluMist TM vaccine ( FMV ) strains from circulating influenza strains in clinical samples.
Output: purpose
It is believed that CD4 + T lymphocytes play an important role in the pathogenesis of this disease by mediating the demyelination of neuronal axons via secretion of proinflammatory cytokines resulting in the clinical manifestations.
Output: background
In this article , we propose two well-defined distance metrics of biological sequences based on a universal complexity profile.
Output: purpose
Clade 2 comprised six proteins exclusive to Sarbecovirus and Hibecovirus.
Output: finding
The G protein has an amino-terminal signal sequence and a stop-transfer sequence located near the carboxy terminus.
Output: background
Results : The results showed that 179/217 ( 82.5 % ) samples were positive with the singleplex method and 183/217 ( 84.3 % ) with the FTD ® Respiratory Pathogens 33 multiplex test.
Output: finding
epidemiological status of the individuals , and intervention measures.
Output: method
For control of influenza , firstly it is important to find the real virus transmission media.
Output: background
and tRNA cleavage among others.
Output: background
His respiratory status worsened , and after about 5 h he was intubated.
Output: background
Only CDV was significantly more prevalent in CAI than HAI dogs.
Output: finding
The primary endpoints were laboratory-confirmed bacterial colonisation and viral respiratory infection.
Output: method
Here , we propose fully 34 differentiated human airway epithelium cultures as a model for studies on the SARS-CoV-2.
Output: purpose
We have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal studies.
Output: purpose
the approach constructs a panel of contiguous cDNAs that span the DENV genome and can be systematically and directionally assembled to produce viable , full-length viruses.
Output: method
This pilot was conducted evaluation comparing performance characteristics of the RT-PCR and Electrospray Ionization Mass Spectrometry ( RT-PCR/ESI-MS ) platform to conventional virological methods for identifying multiple clinically relevant respiratory viruses in nasopharyngeal aspirates.
Output: purpose
The objective of this study was to determine if the period of these infection control measures was associated with changes in overall population mortality due to causes other than SARS.
Output: purpose
Cell surface expressed protein binding assays were conducted using flow cytometry to detect binding of antibodies to HA transfected cells.
Output: method
This is the first report of the successful elimination of faecal FCoV shedding in chronically infected cats.
Output: finding
These data help us to identify important contributors to death that may be remediated through quality assurance and control programs.
Output: purpose
These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.
Output: finding
with a case fatality rate of 5-15 % for HFRS and up to 40 % for HCPS.
Output: background
Results : All patients are passengers without flight attendants.
Output: finding
propels research towards the development of a suitable vaccine candidate.
Output: finding
and 31 low frequency codons inclined to end with C or G in these four species and four subgenomes.
Output: finding
using a bacteriophage surrogate for pathogenic organisms.
Output: purpose
Referring to specific clinical symptoms of pulmonary plague the disease became known as the Black Death.
Output: background
None of the top 5 % most ELISA reactive livestock samples were positive for HCoV-NL63-related viruses by immunofluorescence confirmation.
Output: finding
distribution , and location of G-quadruplexes are features characteristic of each virus class and family.
Output: finding
significant advances have been made recently with several hamster specific immunologic methods being developed.
Output: background
we initially used a green fluorescent protein ( GFP ) to tag the antigen in transient expression.
Output: method
In this study , we assessed the feasibility of producing a protective antigen for the PEDV spike protein 1 using duckweed , Lemna minor.
Output: purpose
Electron-microscopic analysis was used for the identification of caveolae.
Output: method
In this study we used high temporal and spatial resolution animal position data to construct a high-resolution contact network relevant to infectious disease transmission.
Output: purpose
Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals.
Output: background
leaving only the untagged recombinant protein in the column effluent.
Output: method
United States , which is a state with large urban centers as well as a sizeable rural and agricultural population.
Output: background
Objectives Our study aimed to estimate the frequency of human bocavirus ( HBoV ) infection among pediatric populations in Argentina , Nicaragua and Peru.
Output: purpose
In the first decade of democratic rule in South Africa scheduled commercial passenger flights across the countryÕs borders more than doubled.
Output: background
All vaccinated groups appeared to be protected based on body weight gain and lesion scoring.
Output: finding
These patients travelled with a group of 29 other Dutch travellers.
Output: background
Here , we describe the epidemiology and genotype distribution of HAdVs associated with RTIs in Beijing , China.
Output: purpose
We describe the clinical and virologic features of URIs that remain uncomplicated and those that precede an episode of sinusitis.
Output: purpose
and 3.7 L of distilled water were added to the RNA-primer mixture.
Output: method
Our findings therefore suggest that ITIS is unlikely to be effective for entry screening of travellers to detect influenza infection with the intention of preventing entry of the virus into a country.
Output: finding
Colostral Ig preparations designed for farm animals have been commercially available for many years.
Output: background
Theiler 's murine encephalomyelitis virus infection of susceptible strains of mice is an example of viral infections of the CNS as a prerequisite for demyelination.
Output: purpose
We assumed isolation prevented all further transmission in the model.
Output: method
bringing together key international players in the field and Singapore-based researchers and clinicianscientists.
Output: purpose
The absence of a-casein also significantly inhibits transcription of the other casein genes.
Output: method
Taken together , these results reveal that Tat directly transactivates Egr-1 expression and suggest that Tat interaction with Egr-1 is probably one of the very upstream molecular events that initiate Tat-induced astrocyte dysfunction and subsequent Tat neurotoxicity.
Output: finding
This review highlights strategies exploiting these capabilities to improve the understanding of how precisely-displayed cues interact with immune cells and tissues.
Output: purpose
associated with a reactivation of an EBV infection.
Output: purpose
Our principal objective is to develop an integrated approach to the surveillance of pathogens circulating in both human and animal populations and assess how frequently they are exchanged.
Output: purpose
The accuracy of the keu SST turbulence model in detecting air flow around a rectangular block is validated by comparing it with the data from the wind tunnel experiment.
Output: method
Here we report comparably high positivity of MERS-CoV antibodies in dromedary camels from northern Mali.
Output: purpose
Understanding the transmission pattern of the virus and the efficacy of transmission control measures is crucial to ensuring regional and global disease control.
Output: purpose
and 40 reported direct skin-to-skin contact.
Output: finding
e.g. HCV , SARS-CoV , HSV-1.
Output: background
Motivation : Accurately determining the atomic structure of proteins represents a fundamental problem in the field of structural bioinformatics.
Output: background
and the levels of control measures.
Output: finding
The predicted start and end of influenza epidemics were compared with observed start and end of such epidemics according to the incidence of ILI.
Output: method
This study completes our active surveillance work on Spanish bat colonies that began in 1992.
Output: purpose
laboratories , daycare centers and residential care homes for the elderly.
Output: method
Here , we will review the most recent findings on the interaction of SARS-CoV and related Coronaviridae members with the type I interferon and cytokine responses and discuss implications for pathogenesis and therapy.
Output: purpose
and had remarkably longer in vivo half-life than T20.
Output: finding
involves the production of brazzein in E. coli as a fusion with SUMO.
Output: finding
Computational docking studies indicated that in all binding poses ATA binds in the YopH active site.
Output: finding
This study surveyed the prevalence of HCoV-NL63 and influenza viruses in patients with influenza-like illness in Taiwan during 2010 e2011.
Output: purpose
Quantitative fit testing requires the purchasing and use of fit testing solutions and associated equipment.
Output: background
and 44 healthy adults , we measured the total number of natural killer ( NK ) and CD158b + NK cells ( CD158b + NK ) using flow cytometric analysis and calculated the percentage of CD158b + NK cells.
Output: method
and mouse hepatitis virus ( MHV ).
Output: method
These 28 samples were categorized into cohorts E ( < 14 dpd , acute phase ) and F ( > 14 dpd , convalescent phase ).
Output: method
and 77.76 ± 12.53 % of total reads respectively.
Output: finding
No antiviral therapeutics have yet received regulatory approval or demonstrated clinical efficacy.
Output: background
Results : Overall , 273 absences > 7 days were recorded and 36 clusters of at least two absences > 7 days were identified ; a total of 94 HCW were involved in these clusters.
Output: finding
which is termed as `` immunosenescence ''.
Output: background
We hypothesized that population level usage of face 39 masks may be negatively associated SARS CoV-2 spread.
Output: purpose
Here we provide an overview of the current understanding of viral-induced autoimmunity and the mechanisms that are associated with this phenomenon.
Output: purpose
the organisational learning which had occurred.
Output: purpose
β2microglobulin , and heavy chain of a MHC class I molecule connected by flexible linkers.
Output: method
whereas the integrated viral genomes become de novo methylated in specific patterns.
Output: background
The objective of this report is to analyze the value of CMV viral load ( VL ) in bronchoalveolar lavage ( BAL ) in recipients of allogeneic hematopoietic stem cell transplantation ( AHSCT ) and to analyze the concordance between CMV quantification in plasma and BAL samples.
Output: purpose
which together possess 22 potential N-glycosylation sites.
Output: background
12 ( 80 % ) occurred during the first 2 weeks after ICU admission.
Output: finding
Here , we describe a novel vaccine that protects against emerging CHIKV infection of non-human primates ( NHP ).
Output: purpose
Here we describe an efficient strategy for the construction of a large naïve phage-display human Fab library with one-step cloning.
Output: purpose
We developed a multiplex asymmetric reverse transcription ( RT ) - PCR assay that can simultaneously differentiate all influenza A virus epidemic subtypes.
Output: purpose
We provide the first large-scale epidemiological analysis of ARDS incidence and outcomes in Asia.
Output: finding
R 0 , of 2019-nCoV in the early phase of the outbreak.
Output: background
biodistribution , and potential for genomic DNA integration in normal vaccinated rodent.
Output: purpose
and blood samples from 828 residents during November 2015 and December 2015-January 2016.
Output: method
Fathead Minnow Nidovirus , and Viral Hemorrhagic Septicemia Virus.
Output: finding
Multiplex immunoassay can be readily realized by using yeast cells expressing different intracellular fluorescent proteins to display different antigens.
Output: method
Finally , by temperature block experiments we have determined that maturation of GP-C oligosaccharides to an endoglycosidase H resistant form precedes cleavage to GP-1 and GP-2.
Output: finding
In this trial 40 Holstein calves were randomly assigned to receive milk replacer with a prebiotic supplement ( 20 g/day Prebio Support ™ ; Meiji Feed Co. , Ltd..
Output: method
Time series modeling of long-term historical EMR data can reduce the time it takes to discover epidemics of ARI.
Output: finding
deficiency could largely be compensated by Ly49Hmediated antiviral NK cell responses.
Output: finding
The envelope glycoprotein ( Env ) of the human immunodeficiency virus type 1 ( HIV-1 ) includes the gp120 surface subunit and the gp41 transmembrane subunit.
Output: finding
we detect that knocking down GLTSCR2 by shRNAs results in significant suppression of viral replication in mammalian and chicken cells.
Output: finding
a replication model for severe acute respiratory syndrome ( SARS ) infections ( Subbarao , K.transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus ( SARS-CoV ) in the respiratory tract of mice.
Output: purpose
An additional palmitoylation site was observed in CK/SWE/082066 / 2010 a QX-like strain.
Output: finding
Group II : mycetoma patients ( n = 70 patients ; median age 25 ( range 13 to 70 60 years ) ).
Output: method
Then , the recombinant fragment in pMD18-T was subcloned into corresponding sites of prokaryotic expression vector pGEX-6P-1 after digestion with EcoRI and XhoI to construct a recombinant fusion expression vector pGEX-6P-M.
Output: method
and its prevalence is largely unknown except cases of local outbreaks.
Output: background
Sequence analyses were performed to detect any recombination event among IBVs.
Output: method
To analyze the course of seasonal viral infections of respiratory tract in patients hospitalized in pediatric intensive care units ( PICU ) of 16 centers in Turkey.
Output: purpose
Moreover , the present study focused on infectious diseases.
Output: background
A review of some methods for analysis of space-time disease surveillance data is presented.
Output: purpose
as indicated by the possibility to correctly assign up to two-thirds of viruses to their exact class based on the G-quadruplex classification.
Output: finding
dence time at the cell surface.
Output: background
We determined that sulfated glycans in agar inhibited plaque formation by wildtype CVB3 but not by N63Y mutant CVB3.
Output: finding
The most productive search term was intensive care.
Output: finding
thus saving critical time for 37 disease control.
Output: purpose
Implications for the mitigation of the swine-origin infl uenza A H1N1 pandemic are also discussed.
Output: purpose
This study reports on the simultaneous administration of live NDV or aMPV subtype B vaccines alongside two live IBV ( Massachusetts-H120 and 793B-CR88 ) vaccines in day-old maternal-antibody positive commercial broiler chicks.
Output: purpose
nearly half were written in Mandarin.
Output: method
We used the SARS-CoV apo X-ray structure to develop a model of the NL63-PLP2 catalytic site.
Output: method
Here we ask whether there are general properties that make a contact network intrinsically vulnerable to epidemics ( that is , regardless of specific epidemiological parameters ).
Output: purpose
The surveillance and prevention of pathogenic microbiological contamination are the most important tasks of biosafety management in the lab.
Output: background
can combine with small numbers of intermediate steps to create coherent oscillation.
Output: finding
Altogether , these results reveal heparan sulfate as a new attachment receptor for henipaviruses and as a potential therapeutic target for the development of novel approaches against these highly lethal infections.
Output: finding
Here , we compare substrate specificities of the papain-like protease ( PLpro ) from the recently emerged Middle Eastern Respiratory Syndrome ( MERS ) hCoV to the related protease from SARS , SARS PLpro.
Output: purpose
threatening restoration efforts of this species in North America.
Output: background
aimed at a revision of the Coronaviridae taxonomy.
Output: purpose
Objective : To investigate racial differences in time to melanoma treatment.
Output: purpose
The objective of this study was to investigate the effect of equine arteritis virus ( EAV ) on type I interferon ( IFN ) production.
Output: purpose
and the G-quadruplex field has been growing dramatically over the last decade.
Output: background
All of the hamsters infected with the APMVs produced serotype-specific HI or neutralizing antibodies , confirming virus replication.
Output: finding
Maximum likelihood analysis was conducted by using Molecular Evolutionary Genetics Analysis 6.06 ( 7 ).
Output: method
provided counseling services to residents concerned about radiation health risks or mental health issues.
Output: background
This study aims to investigate the utility of next generation sequencing ( NGS ) method to detect possible contamination in the microbiology laboratory.
Output: purpose
leading to the generation of MEDI8852.
Output: method
and Dengue virus serotype 2 ( DENV-2 ).
Output: method
as well as the conditions for their handling and use in downstream processes.
Output: purpose
This two-part article will review the molecular basis of each technology and how the technology has been applied to clinical diagnostic systems.
Output: purpose
Despite the clinical relevance , dengue virus ( DENV ) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses.
Output: background
Understanding the mechanisms that regulate innate immune responses to IAV and other viruses is of key importance to develop novel therapeutic strategies.
Output: background
he or she has a collection of favorite locations.
Output: method
Collectively , these results have implications for the refolding of pneumovirus and paramyxovirus fusion proteins and should inform development of prefusion-stabilized RSV F vaccine candidates.
Output: finding
Comparative analysis of the lipid compositions of CyHV-3 and CCB membrane fractions revealed strong similarities between the lipid composition of the CyHV-3 and CCB lipid rafts.
Output: finding
a general strategy was designed to obtain polyclonal and particularly monoclonal antibodies specific of the 6HB motif of the Pneumovirinae fusion protein.
Output: method
China , which strongly suggests that the reported cases constitute only a small fraction of the actual number of infected individuals in China 2.
Output: finding
He was then transferred to the University of Chicago Medicine MICU.
Output: background
considering as principal vector Aedes aegypti.
Output: method
not cyclophilin B. Cyclophilin inhibitors abolish this interaction.
Output: purpose
underscoring its potential key role in the development of unbiased NGS-based clinical assays in infectious diseases that demand rapid turnaround times.
Output: finding
This study first describes the dynamics of antibody response in infected ducks and identifies frequently recognized antigens that may serve as diagnostic markers of infection by T. regenti.
Output: purpose
NK cells can directly sense and kill MCMV-infected cells.
Output: background
African lineages of MERS-CoV do not establish themselves in Saudi Arabia.
Output: finding
the SARS outbreak , as well as the ever-present threat of global bioterrorism.
Output: background
Inactivation of YopH activity would lead to the loss of bacterial pathogenicity.
Output: background
Three class I genes ( FLAI-H , I-K , I-E ) may encode functional classical class I antigens based on deduced amino acid sequence and promoter structure.
Output: background
Two types of silver nanowires were 60 nm and 400 nm in diameter , respectively.
Output: method
Methods : ITIS was used to measure cutaneous temperature in 1275 airline travellers who had agreed to tympanic temperature measurement and respiratory sampling.
Output: method
there is no uniform inclusion of respiratory viral infection management in the clinical hematology routine.
Output: background
but minimal signs of haemorrhage in the lesion.
Output: finding
The latter process is most likely to occur in the Golgi or post-Golgi compartment.
Output: finding
pathology , histopathology , virus replication , and seroconversion.
Output: method
Error bars show 95 % confidence interval.
Output: method
are deposited during embryogenesis in bone marrow and other organs as a backup population for adult tissue committed stem cells ( TCSCs ) and are involved in several processes related to tissue or organ rejuvenation , aging , and cancerogenesis.
Output: purpose
Study Design and Methods-The distribution of blood groups was investigated within a cohort of 374 WNV + blood donors including 244 asymptomatic ( AS ) and 130 symptomatic ( S ) WNV + blood donors.
Output: method
In this article , we identify key concepts and components associated with this emerging research theme.
Output: purpose
Toward this goal , we performed two-dimensional gel electrophoresis fractionation coupled to mass spectrometry identification approaches to perform a comprehensive proteomic analysis of purified IBV particles.
Output: method
We propose that highly efficient ؊ 1 PRF in TMEV provides a mechanism to escape the confines of equimolar expression normally inherent in the single-polyprotein expression strategy of picornaviruses.
Output: finding
Diarrheic calves had higher odds of BCoV presence than healthy calves ( OR : 2.16 , 95 % CI : 1.26 to 3.83 , P = 0.004 ).
Output: finding
and 78 were enrolled in this study from August 2003 to March 2018.
Output: method
the total seropositive rate for IgM and IgG was 50.0 % and 92.1 % , respectively.
Output: finding
ie , whether this occurs in the healthy CNS or only during inflammatory conditions and what the related cytokine microenvironment is comprised of.
Output: background
whereas the inhibitory activity towards S-adenosyl-L-homocysteine ( SAH ) hydrolase will be retained.
Output: method
In Sulfolobus solfataricus DnaG and Rrp4 but not Csl4 show preference for poly ( rA ).
Output: background
was used for lethal challenge in animal experiments.
Output: method
Furthermore , we determined the complete genomic sequence of BP-caKII to understand the genetic changes related to cold adaptation.
Output: method
and to determine the clinical significance of respiratory pathogens in TB patients.
Output: purpose
( 2 ) mos t component s of th e immunologi c syste m i n huma n mil k ar e produce d throughou t lactation an d durin g gradua l weaning ; ( 3 ) th e factor s ar e usuall y commo n to othe r mucosa l sites ; ( 4 ) the y ar e adapte d t o resis t digestio n i n th e gastrointestinal trac t of th e recipien t infant ; ( 5 ) they protec t b y noninflammatory mechanisms ; an d ( 6 ) th e agent s ac t synergisticall y wit h eac h othe r or with defense agent s produced b y the recipient.
Output: finding
we also identified ARI episodes among other children < 5 years old in the same household.
Output: method
but als o supplie s a hos t o f defens e factor s fo r th e protectio n o f th e recipient and/o r th e mammar y gland.
Output: background
Interpretation : We found that in most scenarios contact tracing and case isolation alone is unlikely to control a new outbreak of 2019-nCov within three months.
Output: finding
In the simulations we account for uncertainty in the number of secondary cases in the absence of air traveller targeted interventions and the arrival times of infected cases and also present sensitivity analyses on arrival rates of infected travellers and the effectiveness of traveller sensitisation.
Output: method
Respiratory viruses of human origin infect wild apes across Africa , sometimes lethally.
Output: background
We conducted a simulation study to compare clinical case finding with syndromic surveillance for detection of an outbreak of inhalational anthrax.
Output: method
The review highlights knowledge gaps in these research areas.
Output: purpose
Here , we present The Genome Detective Coronavirus Typing Tool that can accurately identify novel coronavirus ( 2019-nCoV ) sequences isolated in China and around the world.
Output: purpose
In this study , we demonstrate that treatment of Vero E6 cells with interleukin-4 ( IL-4 ) decreased the susceptibility of these cells to SARS-CoV infection.
Output: purpose
Finally , the projected epitopes were ranked based on their scores and binding modes through using Moe 2007 program.
Output: method
This study aims to use bibliometric analysis to estimate the global activity within this rapidly developing field and to identify particular areas of focus that are of current relevance to the MGBA during the last decade ( 2009 ) ( 2010 ) ( 2011 ) ( 2012 ) ( 2013 ) ( 2014 ) ( 2015 ) ( 2016 ) ( 2017 ) ( 2018 ).
Output: purpose
Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents.
Output: background
activation , and maintenance as well as characteristics of B cell responses and antibody levels during ageing in relation to other cells and factors that are interwoven with B cell biological processes.
Output: purpose
and are likely to fail because of the enormous number of unsampled viruses that could conceivably emerge in humans.
Output: purpose
Information about critically ill patients with SARS-CoV-2 infection is scarce.
Output: background
inactivate , and inject , '' fi rst invoked by Louis Pasteur.
Output: background
This was confirmed by Western blot analysis.
Output: method
which provided a new insight to the pathogenic mechanism of SARS-CoV-2.
Output: finding
and suggest that under certain conditions inhibition of A20 might be of interest in the management of IAV infections.
Output: finding
while control group was supplied with an identical meal without virus.
Output: method
Still disappointing results from a seductive idea • Mucosal surfaces of the respiratory tract represent a major portal of entry for most human viruses and a critical component of the mammalian immunologic repertoire.
Output: background
the cross antiviral activity of a neutralizing antibody against enterovirus 71 ( EV71 ) and coxsackievirus A16 ( CVA16 ) was investigated in vitro.
Output: background
We investigated two patients who developed acute respiratory syndromes after independent contact history with this market.
Output: purpose
thereby promoting viral dissemination within the host.
Output: background
Canine distemper virus ( CDV ) invades the nervous system and replicates in neurons and glial cell of the white matter during a period of severe viral induced immunosuppression.
Output: background
with the assumption that if the same screening effort used in other cities applied in Wuhan.
Output: method
which facilitates viral attachment , entry and membrane fusion is heavily glycosylated and plays a critical role in the elicitation of the host immune response.
Output: background
Additionally , the expert decision analysis process was modified to quantitatively resort types ; these assessments involve multiple criteria and interdependent features.
Output: method
Participants : 63 557 subjects aged 0-19 years with fall injury record were included in the analysis.
Output: method
The population genetics of the family Partitiviridae was studied within the European race of the conifer pathogen Gremmeniella abietina.
Output: purpose
Khuzestan Province , Iran by performing fecal examination and autopsy.
Output: method
lo que evidencia que aproximadamente la mitad de los terneros se infectaron con BCoV.
Output: finding
The epithelia exposed to 95 % oxygen and 5 % carbon dioxide were pseudostratified.
Output: finding
By contrast , the pyrophosphate analogue foscarnet blocks viral genome replication by directly inhibiting HSV DNA polymerase activity ( 4 ).
Output: background
mientras que los animales con títulos bajos de IgG1 ( < 1.024 ) estuvieron predispuestos a la infección.
Output: finding
All the six AMI patients were aged > 60 years ; five of them had two or more underlying comorbidities ( hypertension , diabetes , cardiovascular diseases , and chronic obstructive pulmonary disease ).
Output: finding
clinical and risk factor data were collected at enrollment in children aged < 15 years presenting to an emergency department with an ARI and where cough was a symptom.
Output: method
We used the bivariate random effects model for quantitative meta-analysis of the results.
Output: method
In the present study , the influence of the administration of rFeIFN on blood markers of inflammation ( a-globulins , a 1acid glycoprotein ) and immune system activation ( g-globulins , IgG , IgM , specific anti-feline parvovirus IgG or IgM ) was evaluated in a cattery developing an outbreak of feline panleukopenia due to feline parvovirus ( FPV ) infection few days after initial administration of rFeIFN.
Output: purpose
7.75 log 10 plaque-forming units ( PFU ) / mL.
Output: method
Virus entry and virus-induced syncytium formation using the CAT-1 receptor are mediated by a small number of critical amino acid residues in receptor and virus Env.
Output: finding
Here , this system was compared with an autotransporter protein surface display system.
Output: method
it was significantly lower ( p < 0.01 ) for test positive herds.
Output: finding
• Factors likely to induce mucosal antibody and cell-mediated immune responses include oral or respiratory routes of immunization and active ( effectively replicating ) vaccine agents.
Output: background
To date , however , the utilization of this sequence data to rapidly produce relevant experimental results or actionable treatments is lagging in spite of obtained sequence data.
Output: background
Over 20,000 people have received the vaccine in clinical trials ; the vaccine has proven to be safe and well tolerated.
Output: method
although protein and RNA biochips are also briefly considered.
Output: purpose
including Centor score , were analysed in relation to pathogens.
Output: method
IL-6 , IL-8 , IL-10 and tumor necrosis factor ( TNF ) in bronchoalveolar lavage fluid ( BALF ) as potential biomarkers for pulmonary infection in lung-transplanted patients.
Output: purpose
a potentially lethal disease , feline infectious peritonitis ( FIP ) occurs.
Output: background
quality control measures , and assay parameters used to identify respiratory viruses.
Output: background
Here we highlight three main efforts that have progressed the implementation of One Health in Kenya.
Output: purpose
Moreover , EV71 infection also increased the release of IFN-β and IL-12 p40.
Output: finding
management methods , and clinical outcomes.
Output: method
Cairo University over one year included children presenting with symptoms of acute respiratory infection.
Output: method
Objective : The goal is to present a ranking algorithm able to select the best documents for clinicians considering aspects related to the relevance and the quality of said documents.
Output: purpose
For adaptive immunity , viral antigens can be processed in autophagosomes by acidic proteases before major histocompatibility complex ( MHC ) class II presentation.
Output: background
and applies them to the choice of suitable RNA-dependent RNA polymerase ( RdRP ) target-template pairs within human-infective RNA virus genera.
Output: purpose
Sixty-five outbreaks contained complete data on both onset dates and ward position.
Output: finding
In this paper , we demonstrate the uses of some simple mathematical models for the study of disease dynamics in a pandemic situation with a focus on influenza.
Output: purpose
a positive reaction could be obtained when an infected gill tissue sample that contained 430 viral copies/μg was diluted up to five orders of magnitude.
Output: finding
Dendritic cells ( DC ) are critical to an integrated immune response and serve as the key link between the innate and adaptive arms of the immune system.
Output: background
The cat was palliatively managed using rutin and a low-fat diet.
Output: method
This interaction was mediated by the N-terminal acidic domain of nsp3.
Output: finding
receptor usage , cellular source and biological activities.
Output: background
Conclusion : IFN-γ +874 A allele was shown to be a risk factor in SARS susceptibility.
Output: finding
The resulting tetra-mutant G11A/L141T/R298A / Q299A is indeed enzymatically active as a monomer.
Output: finding
Results from the present study provide further support to the classification of partetraviruses as a separate genus in Parvovirinae.
Output: finding
respectively , were predicted to be cleaved into 16 subunits by two viral proteinases.
Output: method
Why organisms have different mutation rates is a longstanding question in evolutionary biology.
Output: background
This phenomenon can be well explained by a mean-field approximation.
Output: finding
Ramsay Hunt syndrome with laryngitis due to varicella zoster virus was suspected and the patient was started on acyclovir and steroid therapy.
Output: method
We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia.
Output: purpose
and 35 d following diagnosis.
Output: method
Cotton ( Gossypium spp. ) is the main source of renewable textile fibers and is also grown to produce vegetable oil and high protein meals for humans and livestock ( 23 ).
Output: background
IEM methods assist with the detection ofsmall viruses or viruses present in low numbers while PAG offers increased sensitivity over direct EM and IEM.
Output: method
Here , we report an in-flight transmission cluster of COVID-19 and describe the clinical characteristics of these patients.
Output: purpose
The hemagglutinin-esterase ( HE ) gene of Breda virus serotype 2 ( BRV-2 ) has been identified and the nucleotide sequence for BRV serotype 1 ( BRV-1 ) genome which contains the open reading frames for the viral structural proteins has been reported revealing the presence of a 1.25 kb gene whose nucleotide sequence is identical to that of the BRV-2 HE gene.
Output: background
including the muscle , the retina and the brain.
Output: purpose
We assumed that syndromic screening would reduce the number of infected arrivals and that traveller sensitisation reduce the average number of secondary cases.
Output: method
This review will cover the most recent knowledge regarding viral and non-infectious of pregnancy losses in the dog and cat.
Output: purpose
associated with a major epidemiological transition that is accompanied by an unexpected rise of new and emerging infectious diseases.
Output: background
Furthermore , sIFITM3 blocked FMDV infection at early steps in the virus life cycle by disrupting viral attachment to the host cell surface.
Output: finding
multiple sclerosis ( MS ).
Output: purpose
A culture specimen from tracheal aspirates grew methicillin-susceptible S. aureus.
Output: finding
Heterologous production of brazzein is complicated by the fact that the protein contains four disulfide bridges and requires a specific N-terminal sequence.
Output: background
Bangladesh has experienced a variety of diseases caused by natural dissemination of an array of pathogenic microorganisms into the environment.
Output: background
The authors present a mathematical and ethical justification for a palliative care surge plan and outline some of the key elements that should be included in such a plan.
Output: purpose
Ghanaian domestic livestock are not likely intermediate hosts of HCoV-NL63-related coronaviruses.
Output: finding
although it is involved in PDCoV infection.
Output: finding
mRNA for tumor necrosis factor a and interleukin lfl was detectable.
Output: finding
CRTC1 interacts with CREB and they are mutually required for the recruitment to the preS2/S promoter on cccDNA and for the activation of HBV transcription.
Output: finding
antiviral therapy is an important complement that can not be substituted.
Output: background
Mainly positive-strand RNAs were synthesized and protein synthesis was not required for RTC activity in vitro.
Output: method
and transmission electronic microscopy revealed the presence of an enveloped virus morphologically compatible with a coronavirus isolated in the cultures.
Output: method
the two main groups of these viruses in Australia.
Output: method
These patients are subject to a separate AGIHO guideline ( 1 ).
Output: finding
The primary objective of this panel discussion was to seek input on the following 3 questions from the speakers at the workshop.
Output: purpose
• Intracerebral haemorrhage is an uncommon presentation of ITP.
Output: finding
patients with a confirmed diagnosis of SARS had significantly different clinical features and timing of mortality from those of the control group.
Output: finding
Furthermore , rRNA-derived transcripts with heteropolymeric tails were degraded faster by the exosome than their non-tailed variants.
Output: finding
The HN glycoprotein has a single sequence near the amino terminus that functions as both a signal-sequence and a transmembrane-spanning segment.
Output: background
and imported into Microsoft ® Excel.
Output: method
This article details some of the infectious disease pharmacogenomics to the developments in this area.
Output: purpose