niryuu/sni-each-converted huggingface dataset:
Until the 18 th century many European cities were frequently affected by other great plague epidemics.
Output: background
and canine parain £ uenza virus.
Output: background
recent studies suggest that the conjunctiva may represent a possible transmission route ( 5 , 6 ).
Output: background
The isolate from the infant ( S1 , isolated from a tracheal sample ) and 7 isolates from the 6 health care workers ( S2 , isolated from skin lesions of 1 physician ; S4 and S5 , from nasal and anal samples from another physician ; and S3 , S6 , S7 , and S8 , from nasal samples from 4 nurses ) were genotyped and analyzed for the presence of the PVL gene.
Output: finding
However , practical deployment of the technology is hindered by the bioinformatics challenge of analyzing results accurately and in a clinically relevant timeframe.
Output: background
66.7 % of ovine liver samples and 71.4 % of ovine spleen samples.
Output: finding
it is of paramount importance that the best use should be made of the resources available.
Output: finding
We show that aged mice ( 16-19 months old ) are more resistant to influenza A virus ( IAV ) infection than the young mice.
Output: finding
The degree of SCUB divergence varies greatly among different species and genes ( 4-7 ).
Output: background
Here we use a murine model for evaluation of the induction of humoral and cellular immune responses by inactivated and PHE-CoV DNA vaccines in order to define the immune correlates for protection against PHE-CoV.
Output: purpose
The speed of the spread of the SARS epidemic was unprecedented due to the highly efficient intercontinental transportation.
Output: background
In this study , we determined the crystal structures of two neutralizing human antibodies bound to prefusion RSV F.
Output: finding
The results show that we can get satisfactory information from financial markets by this method.
Output: finding
and both 3xTg and 3xTgQ - / - were backcrossed to the BUB mouse strain which has higher in vitro hemolytic complement activity.
Output: method
We recently observed six cases of generalized dermatitis associated with Malassezia overgrowth in cats presented to the Veterinary College of Alfort , France.
Output: background
IgG1 Abs from colostrum origin are critical for prevention of BCoV infection.
Output: finding
In this report , the swine IFITM3 ( sIFITM3 ) gene was cloned.
Output: background
partially overlapping , transcriptional program initiated by the interaction with specific receptors.
Output: background
underwent phagosomal escape but were cleared from the host cytosol.
Output: finding
However , the pathogens have never been detected in the local human population prior to or at the same time as an outbreak.
Output: background
This review discusses some of the key aspects of inflammatory monocyte trafficking to the brain and addresses the role of these cells in viral encephalitis.
Output: purpose
associates with mitochondrial proteins and alters mitochondria morphology to promote infection.
Output: finding
It was notable that blood flow from the trachea was observed during intubation.
Output: finding
Clustering results based on relative synonymous codon usage ( RSCU ) values could provide useful reference for phylogenetic relationship analysis ( 18,19,22 ).
Output: background
In this review we examine protein-G-quadruplex recognition in physiologically significant conditions and discuss how to possibly exploit the interactions ' selectivity for targeted therapeutic intervention.
Output: finding
Moreover , we designed the double-quencher probes ( YCH assay ) according to the oligonucleotide sequence established by NIID.
Output: method
Bioinformatics analysis of this non-structural protein has now revealed a nidoviral signature domain ( genetic marker ) that is N-terminally adjacent to the RdRp and has no apparent homologs elsewhere.
Output: background
referred to as antigenic site Ø.
Output: background
Median calf age at enrollment was 11 d and ranged from 1 to 26 d of age.
Output: method
Therefore , the objective of this study was to examine changes in gene expression and investigate molecular pathways involved in the immune-competence development of neonatal Holstein dairy calves and naturally suckled beef calves using next generation RNA-sequencing during the first week of life.
Output: purpose
IL-6 , IL-10 , and TNF-α.
Output: finding
Researchers collected questionnaire data from international leisure and business tourists to Thailand on importance of safety and security measures.
Output: method
the crossover points usually consist of two to six identical nucleotides.
Output: background
In this study , we investigated recombinant Modified Vaccinia virus Ankara ( MVA ) for delivery of NiV-G antigens ( 46 ).
Output: purpose
we construct a new community network model in which the communities show significant differences in average degree.
Output: purpose
Penta-O-galloyl-glucopyranose ( PGG ) was identified as the most potent gallotannin.
Output: background
and could thus slow the pace of resistance development.
Output: purpose
Plants are low-cost bioreactors for the production of various biopharmaceuticals including oral vaccines.
Output: background
Poisson and negative binomial regression models were used to study the trends of injury incidence rate at different body regions.
Output: method
hip joint MRI examinations , pulmonary function tests and hip joint function questionnaires.
Output: method
have been qualitatively and quantitatively insufficient.
Output: background
The majority of SHAPU patients had multiple anelloviruses in their VF.
Output: finding
with a half-life of > 22 days at 37 °C.
Output: finding
A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls.
Output: method
Methods : Archived records from 5 institutions were retrospectively reviewed to identify cases with confirmed neurologic FIP that had undergone antemortem MRI of the CNS.
Output: method
hemoglobin of 14.1 g/dL , and platelet count of 195,000 / μL.
Output: finding
Objectives : The present study aimed to examine the trends and characteristics of fall-related attendance in accident and emergency department ( AED ) by injury type and the trend in associated average length of stay ( LOS ) among children and adolescents in Hong Kong.
Output: purpose
We compare our results across several variants of Susceptible-Infectious-Recovered ( SIR ) compartmental models to quantify the impact of modeling assumptions on our estimates.
Output: method
The V , D and J genes of the IgH DNA sequences were identified using the IMGT database as a reference ( Brochet et al. , 2008 ; Ye et al. , 2013 ).
Output: method
Predictive studies have begun to identify pathogen traits associated with emergence.
Output: background
and respiratory disorders in cattle of all ages.
Output: background
Viral bronchiolitis is a common clinical syndrome aff ecting infants and young children.
Output: background
This allowed the characterization of the protease recognition pockets and the identification of molecular building blocks that can be incorporated into novel antiviral compounds.
Output: method
A multiplex real-time PCR assay using two reactions was developed for the detection and differentiation of these five pathogens.
Output: method
62 Establishing a high-throughput activity assay 63 Recombinant COVID-19 virus M pro with native N and C termini was expressed in 64 Escherichia coli and subsequently purified ( Extended Data Fig. 1a , b ).
Output: background
and providing guidelines to maximize viral particle yield for improved vaccine production at a reduced cost.
Output: finding
with animal abortion waves that had gone unnoticed.
Output: background
focusing on the potential anti-viral or pro-survival mechanism of autophagy.
Output: purpose
homemade ( to be disclosed ) and placebo ( water ).
Output: method
We estimated that the mean R 0 ranges from 2.24 ( 95 % CI : 1.96-2.55 ) to 3.58 ( 95 % CI : 2.89-4.39 ) associated with 8-fold to 2-fold increase in the reporting rate.
Output: finding
Here , we show that p53 represses expression of the rRNA methyl-transferase fibrillarin ( FBL ) by binding directly to FBL.
Output: purpose
In particular , the central role of interferon-g as a primary mediator of CNS pathology during EAE has been challenged by the emergence of Th17 cells producing interleukin-17.
Output: background
Each of the 10 calves was then randomly allocated to one of two groups.
Output: method
diagnostic imaging , and cytologic and microbiologic analysis of bronchoalveolar lavage or transtracheal wash fluid.
Output: method
or by rather sophisticated mathematical methods.
Output: background
such as a facial mask and gloves.
Output: finding
Based on phylogenetic evidence , transmission from humans is likely.
Output: background
but may also depend on sequences removed from the cleavage site.
Output: finding
an interferon ( IFN ) stimulated gene ( ISG ).
Output: background
In this work , a review was done on the most recent publications concerning their antioxidant and anti-inflammatory activities.
Output: purpose
a one-touch computational pipeline for virus identification and discovery from metagenomic NGS data.
Output: purpose
Calves were monitored daily for signs of disease.
Output: method
provides recommendations for current and future use of nonanimal methods and strategies for veterinary vaccine potency testing.
Output: background
The three-dimensional structure of DV fusion peptide bound to DPC micelles was solved by solution homonuclear NMR with an r.m.s.d. of 0.98 Å.
Output: method
moral/ethical reasonings and global public goods frames identified in the literature.
Output: purpose
particularly influenza , more attention is being focused on the effectiveness of infection control procedures to prevent hospital-acquired infections by this route.
Output: background
In particular , it articulates the changing competitive dynamics between LCCs and full-service carriers ( FSCs ).
Output: purpose
with varying relative importance in different species ( 15 ) ( 16 ) ( 17 ).
Output: background
These antibodies have not defined an etiology.
Output: background
Multiple virus detections were found in 81.2 % and 78.9 % of CAI and HAI dogs , respectively.
Output: finding
Clinical signs were monitored daily and oropharyngeal swabs were taken at regular intervals for vaccine virus detection.
Output: method
Sequence comparison and modeling analysis have revealed a putative receptor-binding domain ( RBD ) on the viral spike , which mediates this interaction.
Output: background
emerging pathogens and pandemic outbreaks are an ever-growing threat to the health and economic stability of the global community.
Output: background
This review provides a description of current and potential biological threats that are likely to require nonhuman primates for the development of vaccines and therapeutics.
Output: purpose
Moreover , we would like to perform a detailed stability and bifurcation analysis of the 47 proposed model.
Output: purpose
and mass spectrometry are briefly discussed.
Output: purpose
self-amplification of transcripts and induction of apoptosis were analyzed in transfected mammalian cells.
Output: method
This work represents a first approach to characterise the otter faecal microflora in samples collected in river stretches of the Sado river basin ( Portugal ) during winter 2006.
Output: purpose
Here we report the cloning and characterization of the cDNA and gene encoding porcine DC-SIGN ( pDC-SIGN ).
Output: purpose
The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility.
Output: finding
The sudden emergence of severe acute respiratory syndrome ( SARS ) has boosted research on innate immune responses to coronaviruses.
Output: background
The interaction between SARS coronavirus 3C-like ( 3CL ) proteinase and an octapeptide interface inhibitor was studied by affinity capillary electrophoresis ( ACE ).
Output: background
efficient frameshifting is critically dependent upon virus infection.
Output: finding
by utilizing one-dimensional liquid chromatography mass spectrometry.
Output: method
Subsequently , the compounds were examined for their cytotoxic effects on two different human breast tumor cell lines : MCF7 and MDA-MB468.
Output: purpose
during 2016 we surveyed HLIUs.
Output: method
Given its cost-and time-effectiveness , this quantitative LAMP assay is suitable for screening lake trout populations and for the initial diagnosis of clinical cases.
Output: finding
This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines.
Output: purpose
The polymerases of RNA viruses generally lack proofreading activity and exhibit extremely high mutation rates.
Output: background
This work proposes a framework to test and evaluate PPE with a focus on gown design.
Output: purpose
post exposure , or treatment of Ebola virus disease ( EVD ).
Output: purpose
71 , and 80 , as well as a double proline substitution at residues 55 and 71.
Output: method
and leukotrienes are likely mediators.
Output: background
Pneumonia was defined as two or more respiratory symptoms and signs and an opacity on a chest radiograph as interpreted by the attending physician.
Output: method
patient enablement and patient satisfaction.
Output: method
The striking finding is of reduction in natural killer ( NK ) cells but preservation of activated effector CD8 T lymphocytes ; with viraemia in the patient who had no NK cells.
Output: finding
Results showed that the diagnostic sensitivity and specificity of the assay were 90.9 % ( 10/11 ) and 82.9 % ( 39/47 ) , respectively.
Output: finding
Collectively , these data can delineate pathogenic mechanisms and thereby help maximize beneficial therapeutics.
Output: method
Different alcohols and commercially available hand antiseptics had a virucidal effect against HBV.
Output: finding
Objective : To describe the clinicopathologic features and MRI findings in cases of confirmed neurologic FIP.
Output: purpose
19-cyclolanostane triterpenoid glycosides based on the available relevant scientific literatures from 2000 to 2014.
Output: purpose
We interpret our results in support of the hypothesis that the spring-loaded conformational change is required for fusion.
Output: finding
single mismatch detection and low current response.
Output: background
from viral pathogens with an area under the receiver operating characteristic ( ROC ) curve of 0.73 ( 95 % confidence interval ( CI ) , .69-.77 ).
Output: finding
This chapter comprises the state-of-art advancements in the development of nano-antimicrobial biomaterials for biomedical applications.
Output: purpose
they are capable of rapid spread throughout the host.
Output: background
and systemic adverse events were determined by a blood test.
Output: method
albeit to lower levels than that achieved in Huh7 cells.
Output: method
and 64 % ( 91/143 ) of healthy and diarrheic calves , respectively.
Output: finding
In this work , we investigate how ZIKV modulates SG assembly.
Output: purpose
symptomatic without pneumonia , and viral pneumonia.
Output: method
open-label , randomized , phase III clinical trial.
Output: method
and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19.
Output: method
for all outbreaks , was more extreme than would be expected by chance under the null hypothesis that proximity was not associated with transmission risk.
Output: method
However , it must be applied repeatedly throughout the day due to rapid plasma membrane turnover and the subsequent loss of n-docosanol ( 9 ).
Output: background
inflammation occurs in the demyelinating lesions with progression of the lesions in some animals.
Output: background
i.e. , B4 , B12 , B15 , and B19.
Output: purpose
This response requires pDC-intrinsic MyD88-dependent signaling by Toll-Like Receptors 7 and 9.
Output: background
None of the 30 influenza-positive travellers had tympanic temperature $ 37.8 uC at screening ( 95 % CI 0 % to 12 % ) ; three had no influenza symptoms.
Output: finding
both from their acute impairment of the vocal mechanism and their predisposing influence for the development of serious vocal sequelae.
Output: background
comprising a 5 1 terminal cap structure and a 3 1 poly A tail.
Output: background
such as a certain pH and temperature and a given concentration of cosolvent ( s ).
Output: background
which is regulated through dynamic interplay among intracellular lectins , glycosidases , and glycosyltransferase.
Output: purpose
the average number of secondary cases generated by a single primary case.
Output: method
and there are many factors that can affect their occurrence.
Output: background
Results from death and severe cases showed that LYM % in blood tests were inversely associated with the severity and prognosis of COVID-19.
Output: finding
we collected nine patients with COVID-19 infections who had undergone chest radiography and CT scans.
Output: method
Little is known about the relationship between EV-D68 virus and host cells.
Output: background
real-time monitoring of transmission is vital for containing the spread of COVID-19.
Output: purpose
and ( ii ) the dysregulation of adaptive immunity.
Output: background
leading to the shut-off of mRNA translation ( protein synthesis ) and the assembly of RNA granules.
Output: background
which cross-reacted with H7N9-M2e peptide.
Output: method
Those with lower education levels less often used preventive measures ( aOR = 0.56 , 95 % CI = 0.46-0.69 ).
Output: finding
respectively , per 5 lL PCR reaction input.
Output: method
All local Arabian samples contained strains of the virus that belong to a novel recombinant clade ( NRC ) first detected in 2014 in Saudi Arabia.
Output: finding
nucleotide binding , dimerization , and ribonuclease functions highlights the evolutionary adaptability of the eukaryotic protein kinase fold.
Output: finding
Using these assays , we conducted a one-step real-time RT-PCR with serial DNA positive control to assess the detection sensitivity.
Output: method
which means that a fast prediction method could allow for a high throughput of derived protein structures.
Output: background
Migration of the parasites can be accompanied by neuromotor disorders or paralysis in natural definitive hosts ( ducks ) and even in laboratory mammals.
Output: background
and IL-2 ( RE = 0.312 ).
Output: finding
PVL-producing S. aureus is known to cause rapidly extensive and necrotizing pneumonia in children and young adults.
Output: background
or as star proteins if the protein is fused to both N-and C-termini.
Output: background
We describe isolation of infectious MERS-CoV from the upper respiratory tract of a mildly ill 27-year-old female in Saudi Arabia 15 days after illness onset.
Output: purpose
Ten single Asn-to-Ala substitutions at the predicted N-glycosylation sites of the M41-RBD were evaluated along with two control Val-to-Ala substitutions.
Output: method
The wild-type S was palmitoylated as evidenced by the efficient incorporation of 3 H-palmitic acid in wild-type S molecules.
Output: finding
especially females ( aOR = 1.47 , 95 % CI = 1.27-1.69 ).
Output: finding
Objectives : No data were available about in-flight transmission of SARS-CoV-2.
Output: purpose
and the recent , rapid spread of PHE-CoV in piglets from many countries emphasizes the urgent need for a PHE-CoV vaccine.
Output: background
with a focus on the most recent advances in the development and application of polysaccharide-based antigen nanocarriers.
Output: purpose
The viral ribonucleoprotein complex of human immunodeficiency virus-1 ( HIV-1 ) associates with the viral Envelope ( Env ) to form infectious virions.
Output: background
Data modeling was based on univariate and multivariate data analyses.
Output: method
The aim of the present review is to combine the data on the pre-Golgi compartment with previous ideas of membrane traffic at the ER-Golgi interface.
Output: purpose
and siNS5B targeting NS5B gene describe previously.
Output: method
the viral polymerase , and multiple viral nucleoproteins.
Output: finding
to determine the extent of protection achieved against SARS-CoV challenge in this model.
Output: purpose
3D drafting skills , and computer simulations.
Output: background
Analysis of Singapore 's outbreak improves our understanding of the social dimensions of infectious disease outbreaks.
Output: finding
near the direct contact area with ACE2.
Output: finding
5,997 confirmed and 9,239 suspected cases of 2019-nCoV have been reported from China with 132 deaths confirmed so far 1.
Output: background
The Interferome database was used to identify interferon ( IFN ) signature genes and ingenuity pathway analysis identified canonical pathways and biological functions associated with the differentially expressed genes in LBW newborns.
Output: method
The objective of this study was to obtain insight into the adverse health effects of airborne particulate matter ( PM ) collected from live bird markets and to determine whether biological material in PM accounts for immune-related inflammatory response.
Output: purpose
Therefore , we develop attenuated vaccines from local strains in Taiwan.
Output: purpose
and the sketches application in evaluating the effectiveness of disease intervention strategies as well.
Output: purpose
However , the risk factors for this are maternal smoking and small lungs at birth , rather than allergy.
Output: finding
Model-specific parameters are estimated by Bayesian inference using Markov chain Monte Carlo.
Output: method
The Java source and binary files of the proposed IBS _ SCS algorithm and our implementation of the DR algorithm and all the random and real datasets used in this paper are freely available upon request.
Output: finding
In the present study , we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD.
Output: purpose
Hubei province , has now ceased air travel and closed major public transport routes 3 it is unlikely that these measures will fully contain the outbreak.
Output: finding
multicentric Castleman 's disease , and primary pleural cell lymphoma.
Output: background
We analyzed the radiographic and CT findings of COVID-19 pneumonia at baseline.
Output: method
This review highlights recent discoveries and remaining questions important to understanding the biological functions of ISG15.
Output: purpose
occupy unique ecological niches , and occur globally except for Antarctica.
Output: background
and quantified the weekly maximum number of cases traced to measure feasibility of public health effort.
Output: method
The reaction can be studied in an in-vitro packaging and replication system involving purified procapsids and ssRNA.
Output: method
We identified influenza virus infection in 30 travellers ( 3 Type A and 27 Type B ).
Output: finding
Stool supernatants of uninfected calves served as a control.
Output: method
where there are competing models for the underlying epidemiology an ensemble approach can account for that uncertainty.
Output: method
rotavirus C ( RVC ).
Output: background
immunomodulators levels were evaluated in samples from 74 children ( ≤ 5 years-old ) hospitalized with viral and/or bacterial community-acquired pneumonia.
Output: method
Antigens recognized by the antibodies were identified on Western blots of cercariae and schistosomula.
Output: method
whereas one coronavirus from Pipistrellus coromandra fell in the lineage C of βCoVs which also includes the MERS-CoV.
Output: finding
CyHV-3 has been implicated in a large number of disease outbreaks in carp populations causing up to 100 % mortality.
Output: background
with HIV-1 Gag protein co-expressed in the same cell.
Output: purpose
probably active , indeterminate activity , and probably inactive.
Output: method
Our findings support the need for influenza surveillance and annual influenza vaccination for at-risk populations in tropical countries.
Output: finding
an unpitied sacrifice in a contemptible struggle.
Output: background
Seventy participants ( 23.3 % ) randomized to vitamin D 3 reported clinical URTI compared to 80 ( 26.7 % ) randomized to placebo ( RR : 0.79 , CI 95 : 0.61-1.03 , p = 0.09 ).
Output: finding
54 effect of the strength of psychological fear and impact of heterogeneity in indirect transmission.
Output: method
The recombinants were then used to address the question of the importance of S protein cleavage and viralmediated cell-to-cell fusion on pathogenicity.
Output: method
which also includes DNA and RNA ligases.
Output: background
A logistic regression analysis was employed to explore the explanatory variables influencing the confidence and the perspective.
Output: method
This study aims to determine the safety and effectiveness of rosiglitazone in inadequately controlled type 2 diabetes patients with NAFLD.
Output: purpose
The steady-state levels of CRTC1 protein were elevated in HBV-positive hepatoma cells and liver tissues.
Output: finding
Protein ubiquitylation is an important regulator of protein function , localization and half-life.
Output: background
with the yeast cells as fluorescent labels.
Output: method
Discuss the importance of the Department of Health and Human Services ( HHS ) Category C agents.
Output: purpose
clinical disease , and management accumulated within just 1 year.
Output: background
During three months , a total of 1,815 patients were tested ( including 236 patients infected H1N1sw virus ) and distribution in age groups and results of RIDT were analyzed.
Output: method
The aim of this study was to determine how a homemade solution compared against a commercially available product and a placebo.
Output: purpose
Being age ≥ 65 years ( OR = 4.0 ; 95 % CI : 1.6-9.9 ) and having an intensive care unit admission ( OR = 7.4 ; 95 % CI : 3.0-17.9 ) were independently associated with mortality.
Output: finding
Internal variations within each group can be simulated by assuming the possible distributions for different parameters.
Output: method
331 modern , high-standard , centralized facilities will be built up in China in municipal level cities.
Output: background
As a result , two compounds were identified as the most active.
Output: finding
The overall in-hospital mortality was 57.8 %.
Output: finding
In this paper , we propose to advance and transform today 's healthcare system using a model of networked health care called Cybercare.
Output: purpose
229E , and - OC43 patients.
Output: method
The 100 % detection limit of HIV-1 RT-LAMP was determined using a standard strain ( WHO HIV-1 ( 97/656 ) ) in octuplicate and found to be 120 copies/ml.
Output: method
The results obtained from the microarray study were validated on a larger number of samples using real time RT-PCR ( LBW = 22 , NBW = 18 ) and western blotting ( LBW = 12 , NBW = 12 ).
Output: method
and to explore their perspectives on HMPX.
Output: purpose
Clara cells also function as stem/progenitor cells for repair in the bronchioles.
Output: background
Methods : We conducted a cross-sectional survey of medical students on clinical rotations at two teaching hospitals to determine the type of training they received in PPE technique.
Output: method
The antiviral activity and dose-response of the IgY were determined by assessing the cytopathic effect in rhabdomyosarcoma ( RD ) cells in vitro.
Output: method
united in the order Nidovirales.
Output: background
we demonstrated that Tat increased Egr-1 expression by transactivating the Egr-1 promoter and involving specific serum response elements ( SRE ) within the promoter.
Output: finding
the causative pathogen was identified in cultures of a brain tissue specimen obtained from the patient with SARS.
Output: method
The loss of any one of these responses increases susceptibility to infection.
Output: background
a small molecule inhibitor of the HCV NS5A protein that exhibits picomolar half-maximum effective concentrations ( EC 50 ) towards replicons expressing a broad range of HCV genotypes and the JFH-1 genotype 2a infectious virus in cell culture.
Output: purpose
This paper demonstrated that persistent respiratory syncytial virus infection could contribute to the progression of COPD severity.
Output: finding
while viral mRNA levels in infected cells remained unaltered in both groups.
Output: method
We propose that TDP-43 and FUS serve as an interface between genetic susceptibility and environmental stress exposure in disease pathogenesis.
Output: purpose
Objectives : To measure the spatial contagion of severe acute respiratory syndrome ( SARS ) in Beijing and to test the different epidemic factors of the spread of SARS in different periods.
Output: purpose
10 , No. 2 , February 2004 255 RESEARCH SARS TRANSMISSION Figure.
Output: background
such as SARS-CoV and MERS-CoV.
Output: finding
from 102 screened compounds as an inhibitor of LASV infection.
Output: purpose
The aim of this review was to characterize the effectiveness of contact precautions alone against transmission of any MDRO among adult acute care patients.
Output: purpose
Canine infectious respiratory disease complex ( CIRDC ) is associated with multiple factors.
Output: background
The emergence of proteomic techniques and systems approaches to study disease pathophysiology has rekindled the quest for new biomarkers.
Output: background
We empirically demonstrated the application of the software with a multiplex set of 16 short ( 10 nt ) primers designed to amplify the Poxviridae family to produce a specific amplicon from vaccinia virus.
Output: finding
Binding assay of Kn2-7 to HIV-1 PV by Octet Red system suggested the anti-HIV-1 activity was correlated with a direct interaction between Kn2-7 and HIV-1 envelope.
Output: finding
Fasting paradigms elicit a wide-range of health benefits including suppressing inflammation.
Output: background
We aimed to describe the CT findings across different timepoints throughout the disease course.
Output: purpose
Surprisingly , myeloid cell specific A20 knockout mice are protected against lethal IAV infection.
Output: finding
with protection rates varying between 0 and 80 % according to the geographical area.
Output: finding
and only 10.8 % of the datasets were publicly available.
Output: finding
the present study aimed to devise a novel statistical model to quantify the country-level risk of experiencing an importation of MERS case.
Output: purpose
contact tracing and isolation was only potentially feasible when less than 1 % of transmission occurred before symptom onset.
Output: finding
we examined the role of this receptor variant in cytopathicity and host range.
Output: purpose
and ability to accurately reflect disease progression in humans.
Output: background
but also to family members.
Output: background
shared homologies with two other anti-viral mAbs.
Output: finding
Among contacts , the use of FFP2/FFP3 face masks during aerosol exposure was more frequent after MERS-CoV infection was suspected than before.
Output: finding
The global spread of SARS-CoV-2 requires an urgent need to find effective therapeutics for the treatment of COVID-19.
Output: purpose
Responses obtained from the groups were documented and similar results were aggregated using tallies.
Output: method
We document the development of Fangcang shelter hospitals during the COVID-19 outbreak in China and explain their three key characteristics ( rapid construction , massive scale , and low cost ) and five essential functions ( isolation , triage , basic medical care , frequent monitoring and rapid referral , and essential living and social engagement ).
Output: method
endogenous 46 retrovirus-3 ( ERV-3 ).
Output: method
comparative perspective on the virulence of all currently known human RNA virus species.
Output: finding
In this study , we developed an alignment-free algorithm for faster sequence analysis.
Output: purpose
MyD88 is dispensable for antiviral immunity.
Output: background
Representativ e example s of solubl e defens e agent s ar e liste d i n Tabl e I.
Output: finding
Pigs ( 6 weeks old ) were orally immunized with ITGEV plus CpG DNA.
Output: method
This study utilized primers and single-quencher probes in accordance with the Centers for Disease Control and Prevention ( CDC ) in the USA and the National Institute of Infectious Diseases ( NIID ) in Japan.
Output: method
were retrospectively included in this study.
Output: method
diverse and unalignable sets of target sequences.
Output: background
1 H NMR , 13 C NMR and mass spectral analysis.
Output: background
We developed a mathematical model that characterizes infections by state and incorporates inflows and outflows of interstate travelers.
Output: method
numerous researchers around the world have been working relentlessly to understand the biology of this virus.
Output: background
Practice of meditation or exercise may enhance health to protect against acute infectious illness.
Output: background
including design considerations and areas for future development in the field.
Output: purpose
Herein , we describe a loopmediated isothermal amplification ( LAMP ) assay that was developed for the quantitative detection of EEDV in infected fish tissues.
Output: background
Here we determined the extent and functional importance of macrophage infection by MAV-1.
Output: purpose
All stages of the HSV replication cycle offer potential targets for direct-acting antiviral ( DAA ) therapy.
Output: background
population density , and national response plans it was hypothesized that adherence to recommendations will vary.
Output: purpose
agriculture , and so on.
Output: background
but had little effect on HIV-1 replication in these cells.
Output: finding
and lack the capability to uncover the novel viruses that cause emerging viral infections.
Output: background
This approach provides a useful means to measure potential modulatory effects by virus infections or other agents upon feline macrophage gene expression.
Output: finding
We examined whether emotional acceptance moderates the association between proinflammatory cytokines and self-reported sickness symptoms in women recently diagnosed with breast cancer.
Output: purpose
suggesting alternative mechanisms for TRIM25 action.
Output: background
A screen for known respiratory pathogens was performed on biopsy tissue.
Output: method
To identify inhibitor candidates , we have analyzed hit compounds that emerged from a large-scale high-throughput screen for their ability to block replication of members of both the orthomyxovirus and paramyxovirus families.
Output: purpose
A necropsy was performed , and the findings revealed right lobar pneumonia with a necrotizing hemorrhage of the entire right lung and one-half of the left lung.
Output: finding
Here , we compared the amino acid sequences of several representative CoVs.
Output: method
We selected observational and experimental studies examining the impact on mental health of epidemic outbreaks on HCWs.
Output: method
This paper highlights the growing evidence that Th17 cells play the core role in the complex adaptive immunity of EAE/MS and discusses the roles of the associated immune cells and cytokines.
Output: purpose
indicating a tropism for the respiratory tract.
Output: finding
Animals : Two hundred and eighty-six calves < 21 days.
Output: method
we isolated active RTCs from infected cells and used them to develop the first robust assay for their in vitro activity.
Output: method
NSG and humanized NSG mice were infected with 100 O. volvulus infective larvae ( L3 ) for 4 to 12 weeks.
Output: method
Objective : To determine the viral etiology and epidemiology of ILI in households.
Output: purpose
In this study we show that the detrimental effects of angiotensin II ( Ang II ) were exacerbated in the hearts of aged apelin-gene-deficient mice.
Output: purpose
Young infants are likely to acquire RSV infection from older children in the same household.
Output: finding
In this study , a reverse transcription loopmediated isothermal amplification ( RT-LAMP ) was developed for detection of porcine epidemic diarrhea virus ( PEDV ).
Output: purpose
Nine of these peptides and one unrelated peptide were manually synthesized and their T cell responses were tested in vitro.
Output: method
Hereby , we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China.
Output: purpose
3D G64S , has a significant replication defect and that wild-type ( WT ) and 3D G64S populations have similar adaptability in 2 distinct cellular environments.
Output: finding
Spectrophotometric assays determined G6PD levels.
Output: method
viral persistence is associated with epithelial cells of the nasopharynx in the upper respiratory tract and decreased levels of mRNA for several immunoregulatory cytokines in the infected tissues.
Output: finding
Enhanced surveillance of norovirus outbreaks between November 2009 and November 2011.
Output: purpose
We compared major gene deletions between African and Arabian strains of the virus.
Output: method
Strains were considered genetically distinguishable if their restriction patterns differed by у3 bands ( 3 ).
Output: finding
Study objectives were to explore the vaccination status and determinants in T2DM patients in southwestern Saudi Arabia.
Output: purpose
including the presence of a putative transmembrane protein encoded by an overlapping reading frame in ORF2.
Output: finding
Feline coronavirus ( FCoV ) is common among cats living indoors in groups.
Output: background
and further help in prescribing their vaccines against them.
Output: background
such as attachment and penetration.
Output: background
A Time-LYM % model ( TLM ) was established according to the descriptive studies and was validated in 92 hospitalized cases.
Output: method
E2 , and the E1E2 complex.
Output: method
Design : A retrospective approach was adopted.
Output: method
Results : SARS-CoV N is released from cells through an association with E protein-containing vesicles.
Output: finding
Objective : To optimize clinical laboratory diagnosis of COVID-19 from suspect cases by Likelihood Ratio of SARS-CoV-2 IgM and IgG antibody.
Output: purpose
and critically appraises how this may be applied within Canada.
Output: purpose
Recently , an increasing number of studies have highlighted the promising effects of NM in inhibiting cancer progression.
Output: background
He also reported dark urine and anorexia.
Output: background
It has therefore become more useful to study the similarities between these proteins that goes beyond their sequence homology.
Output: background
G-quadruplexes can readily form under physiologically relevant conditions and are globularly folded structures.
Output: background
2020 , through the exponential growth.
Output: method
are potent inhibitors of translation initiation.
Output: background
In particular , this study pays attention to formulating a mathematical model for MERS transmission dynamics and estimating transmission rates.
Output: purpose
and components of the ubiquitin pathway.
Output: method
in vitro , the phenotype of LPCs to create an ideal niche-like microenvironment.
Output: purpose
PBs and SGs with different compositions may coexist in a single cell.
Output: background
Objectives : This study sought to examine the operational and organizational management of a major outbreak of Middle East Respiratory Syndrome ( MERS ) caused by a novel coronavirus ( MERS-CoV ) in the Kingdom of Saudi Arabia ( KSA ).
Output: purpose
and analyzed its clinical characteristics statistically.
Output: method
Healthcare databases and sources of grey literature were searched in July 2013.
Output: method
and these were analyzed for BRSV and BCV antibodies.
Output: method
focusing on their clinical applications as anticancer vaccines.
Output: purpose
Acute respiratory distress syndrome ( ARDS ) can be associated with various disorders.
Output: background
Nevertheless , timely diagnosis and systematic management of CRV infections in intensively treated hematology patients has a demonstrated potential to significantly improve outcome.
Output: background
A prospective case control study was performed in primary healthcare in Kronoberg County , Sweden.
Output: method
as well as known polyomaviruses.
Output: finding
Finally , a few mechanisms by which infection may exacerbate symptoms of MS and other neurological diseases are discussed.
Output: purpose
35 Further , we also provide basic characteristics of the system.
Output: purpose
political , and economic policies as the foci of upstream drivers of the public 's health.
Output: method
Ongoing and future work will contribute to a more complete understanding of the lifecycles of retroviruses and RNA viruses and potentially lead to novel antiviral strategies.
Output: purpose
Sensitivity analysis using different values of the serial interval showed that there was evidence to reject the null hypothesis provided the assumed serial interval was less than 2.5 days.
Output: finding
prognosis and treatment , and for other broad public health outcomes.
Output: purpose
gastrointestinal and possibly neurological disorders.
Output: background
However , there are few direct comparisons of different PCR assays.
Output: background
Patients with AECOPD requiring hospitalization were recruited.
Output: method
We demonstrated that this did not interfere with translocation and glycosylation and yields biologically active proteins.
Output: finding
demonstrating the capacity of mNGS to identify both known and novel viruses.
Output: finding
a serial interval distribution , and the estimated R0 into a model based on the assumption that daily incidence obeys approximately Poisson distribution determined by daily infectiousness.
Output: method
particularly focusing on how conclusions differ for ` moderate ' ( R 0 1/4 1.7 ) and ` high ' ( R 0 1/4 2.0 ) transmission scenarios.
Output: method
respectively , of cav-1 and cav-2 in airway epithelium.
Output: method
These findings suggest that the resultant infiltration of immune cells into the brain during HSV-1 infection may cause as much damage as the virus itself.
Output: finding
FHTVTVNTL , HTTWTLTGY , and IELAGTLTL were selected.
Output: method
Diseases 2016 , 4 , 26 2 of 28 but with a much higher mortality rate of about 35 % ( 17 ).
Output: background
Analyses performed with geNorm revealed that hypoxanthine phosphoribosyltransferase 1 ( HPRT1 ) and hydroxymethylbilane synthase ( HMBS ) were the two most stable reference genes in response to post-oviposition time alone ( POT ) or with nicarbazin treatment ( POT+N ) of laying hens.
Output: finding
neutralization , and is involved in the induction of protective immunity.
Output: background
On viral infection , `` autophagy '' and `` programmed cell death '' are two dynamically synchronized cell survival programs ; `` immune response '' is a cell defense program typically suppressed by viruses ; `` cell cycle alteration '' and `` lipid metabolic reprogramming '' are two altered cell housekeeping programs tunable in both directions.
Output: background
Infectious bronchitis virus ( IBV ) causes a costly respiratory viral disease of chickens.
Output: background
The aim of this study was to investigate whether co-administration of CQ during sporozoite immunization improves cellular responses and protective efficacy in Plasmodium berghei models.
Output: purpose
Ferret recombinant IL-2 stimulated the proliferation of ferret lymph node cells and induced the expression of mRNA for IFN-g and Granzyme .
Output: finding
In this study , the potential utility of transmission electron microscopy ( TEM ) in detecting nonbacterial pathogens in patients with severe pneumonia was retrospectively evaluated.
Output: purpose
Specific suggestions are made to enhance the infectious diseases physician 's profile with the intent of encouraging debate , discussion , and action.
Output: purpose
HCoV − OC43 infections have rarely been investigated as healthcareassociated infections in this population.
Output: background
We developed an online tool so that results can be updated as new information becomes available.
Output: method
Study design : 152 HAdV positive samples were genotyped by Sanger sequencing of a fragment of the hexon gene using published primers along with a newly developed primer set for enhanced genotyping of HAdV D. Phylogenetic analysis was used for genotyping and genotypes were compared with epidemiological information.
Output: method
Furthermore , the review outlines the aspects remain unclear that urgently need to be solved in future research.
Output: purpose
Sudan and it included 140 individuals.
Output: method
displaying a more resistant phenotype during IAV infection.
Output: finding
Here , we fill this knowledge gap by developing and validating an analytical framework that requires only basic analytics from stochastic processes.
Output: purpose
However , ITP in association with coronavirus infection has not previously been reported.
Output: background
This frans splicing model predicts that the downstream portion of medRNA will be part of a branched structure and then be released as a free product ( minRNA ).
Output: purpose
and Huangshan city in Anhui province.
Output: purpose
and their membrane association and lipase cleavage were determined in cells.
Output: method
In this study , we exposed tracheal organ cultures from rats to 95 % oxygen and 1 ppm ozone.
Output: method
We also identified 38 novel potential protein coding open reading frames that were absent in the current genome annotation.
Output: finding
The cases were found to be older than the other travellers and both had co-morbidities.
Output: finding
as well as ways that have been proposed by the National Institutes of Health to improve the state of this field.
Output: purpose
bacterial expressed proteins in the serodiagnosis of coronavirus infections.
Output: purpose
the One-Health framework can be used to investigate the critical pathways through which viruses are transported and transmitted.
Output: background
Parallel ribosome profiling and RNA sequencing of infected-cell time points was performed during the course of MHV replication in mouse tissue culture cells and used to determine virus gene expression kinetics and the relative translational efficiencies of virus and host mRNAs.
Output: method
healthy adults , and patients with other respiratory virus infections.
Output: method
Metagenomic studies can provide this background but only when combined with essential metadata and following the `` FAIR '' ( Findable , Accessible , Interoperable , and Reusable ) data principles.
Output: finding
potential protease inhibitors , were obtained under parallel solution-phase conditions.
Output: method
along with a discounting factor to project the growth of outbreaks using only basic epidemiological information ( e.g. , daily incidence counts ).
Output: method
After LPS administration , pigs were intensively monitored for clinical signs.
Output: method
We studied the changes in AGP glycosylation in the course of FIP.
Output: purpose
we tested the ability of Hp-BatCoV HKU25 to bind and use hDPP4.
Output: method
The present study reports on the emergence and spread of recombinant clusters detected in Italy and Spain between 2012 and 2014.
Output: purpose
emergence and eventual evolution of a plethora of infectious pathogens.
Output: background
treatment and outcome of children diagnosed with community-acquired MP pneumonia ( CAMP ) in a tertiary hospital in Valencia , Spain.
Output: purpose
Methodology : To characterize the increased susceptibility to infections in LBW newborns we used microarray technology to identify differences in gene expression in LBW newborns ( n = 8 ) compared to NBW newborns ( n = 4 ) using cord blood.
Output: method
The study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex PCR from the nasopharynx of clinically septic patients during a winter season.
Output: purpose
which facilitates BVDV replication in MDBK cells and impairs the innate immune response.
Output: finding
and attitude ( anxiety and perception of open communication with authorities ) were associated with practicing preventive measures.
Output: finding
Such an understanding has practical impact in providing a rational basis for the design and development of antiviral strategies.
Output: background
We conducted a trial assessing the feasibility of using PCT algorithms with viral testing to guide antibiotic use in a US hospital.
Output: purpose
A solid phase colloidal gold immunoelectron microscopy ( IGEM ) technique for detecting bovine coronavirus ( BCV ) was developed and shown to be specific.
Output: purpose