Question: Does fibronectin constitute a serum biomarker for Duchenne muscular dystrophy?

Context:
Fibronectin is a serum biomarker for Duchenne muscular dystrophy
There was a significant increase in fibronectin levels in DMD patients compared to age-matched controls. Fibronectin levels in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were comparable to control levels. Progressive elevation in fibronectin levels was observed in longitudinal samples from 22 DMD patients followed up for a period of 6 months up to 4 years
This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients
Fibronectin is a serum biomarker for Duchenne muscular dystrophy.
Progressive elevation in fibronectin levels was observed in longitudinal samples from 22 DMD patients followed up for a period of 6 months up to 4 years.CONCLUSION AND CLINICAL RELEVANCE: This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients.
There was a significant increase in fibronectin levels in DMD patients compared to age-matched controls.
Progressive elevation in fibronectin levels was observed in longitudinal samples from 22 DMD patients followed up for a period of 6 months up to 4 years.
This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients.
Progressive elevation in fibronectin levels was observed in longitudinal samples from 22 DMD patients followed up for a period of 6 months up to 4 years. This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients.
This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients. © 2014 The Authors PROTEOMICS - Clinical Applications Published by Wiley-VCH Verlag GmbH & Co.
There was a significant increase in fibronectin levels in DMD patients compared to age-matched controls. Fibronectin levels in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were comparable to control levels.
Fibronectin levels in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were comparable to control levels. Progressive elevation in fibronectin levels was observed in longitudinal samples from 22 DMD patients followed up for a period of 6 months up to 4 years.
Fibronectin is a serum biomarker for Duchenne muscular dystrophy.
This study suggests that serum fibronectin levels may constitute a promising biomarker to monitor disease progression in DMD patients.

Answer: Compared to age-matched controls, fibronectin levels in DMD patients were found to be significantly increased, whereas in patients with Becker muscular dystrophy, Bethlem myopathy, or myasthenia gravis were close to the control levels. Additionally, progressive elevation in fibronectin levels was observed in longitudinal samples from DMD patients followed up for a period of 6 months up to 4 years. Therefore, fibronectin is a serum biomarker for Duchenne muscular dystrophy.
Fibronectin is a serum biomarker for Duchenne muscular dystrophy
Exact answer: yes