Query: yuliya shapovalova

title: Non parametric synergy modeling with Gaussian processes
abstract: Understanding the synergetic and antagonistic effects of combinations of drugs and toxins is vital for many applications, including treatment of multifactorial diseases and ecotoxicological monitoring. Synergy is usually assessed by comparing the response of drug combinations to a predicted non interactive response from reference (null) models. Possible choices of null models are Loewe additivity, Bliss independence and the recently rediscovered Hand model. A different approach is taken by the MuSyC model, which directly fits a generalization of the Hill model to the data. All of these models, however, fit the dose response relationship with a parametric model.  We propose the Hand GP model, a non parametric model based on the combination of the Hand model with Gaussian processes. We introduce a new logarithmic squared exponential kernel for the Gaussian process which captures the logarithmic dependence of response on dose. From the monotherapeutic response and the Hand principle, we construct a null reference response and synergy is assessed from the difference between this null reference and the Gaussian process fitted response. We evaluated performance of our model on a simulated data from Greco, two simulated data sets of our own design and two benchmark data sets from Chou and Talalay. We compare the Hand GP model to standard synergy models and show that our model performs better than these standards. We also compare our model to the MuSyC model as example of a recent method which also fits a complete dose response surface. Also in this case, the Hand GP model performs better.  The Hand GP model is a flexible model to capture synergy. Its non parametric natures allows it to model a wide variety of response patterns.

title: STRUCTURAL SET OF THE CONCEPT OF MARKETING MANAGEMENT OF THE INTERNATIONAL ACTIVITY OF THE ENTERPRISE

title: Graphical Causal Models and Imputing Missing Data: A Preliminary Study
abstract: Real world datasets often contain many missing values due to several reasons. This is usually an issue since many learning algorithms require complete datasets. In certain cases, there are constraints in the real world problem that create difficulties in continuously observing all data. In this paper, we investigate if graphical causal models can be used to impute missing values and derive additional information on the uncertainty of the imputed values. Our goal is to use the information from a complete dataset in the form of graphical causal models to impute missing values in an incomplete dataset. This assumes that the datasets have the same data generating process. Furthermore, we calculate the probability of each missing data value belonging to a specified percentile. We present a preliminary study on the proposed method using synthetic data, where we can control the causal relations and missing values.

title: Bayesian inference in multivariate nonlinear state space models
abstract: A submitted manuscript is the version of the article upon submission and before peer review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. The final author version and the galley proof are versions of the publication after peer review. The final published version features the final layout of the paper including the volume, issue and page numbers.

title: Clinical Evaluation of the Root Channel Irrigation Method as an Important Stage in Conservative Treatment of Teeth with Significant Destructive Changes in Periapical Tissues

title: Distance Learning of a Foreign Language Necessity or Future
abstract: In order to effectively organize the educational process when teaching foreign languages remotely in the context of a pandemic, special technical, psychological, and pedagogical training is required to switch to this form of education. Thus, it is necessary to study the current state of distance learning in foreign languages, both in Russia and abroad, and analyze the prospects for the development of this form of education, taking into account factors that have a positive impact on the process of learning a foreign language. The purpose of the article is to identify the theoretical and methodological foundations of distance learning in foreign languages, analyze the factors that have a positive and negative impact on the process of learning a foreign language, and determine the role of a teacher who organizes the process of teaching foreign languages remotely. To solve the problems of the research, a set of research methods was used: system, historical, theoretical analysis and generalization of literature, questionnaires. Statistical data processing was carried out using Google services when conducting surveys used for analyzing and summarizing data, their graphical visualization the results Of a survey of students in one of the leading universities in Russia in the form of distance education revealed positive aspects about the introduction and implementation of distance learning, however, the data obtained on the quality of distance learning agreed, that "live" interactivity in the classroom with classmates and other participants in the educational process leads to the highest results of communicative teaching of foreign languages. As a result of the research on the quality and interest of students and undergraduates in distance learning, 180 students aged 18 to 25 years were interviewed. A retrospective analysis of the development of distance education in Russia and abroad revealed such facts that not all countries were ready to switch to this form of education during the pandemic. Based on the experience of working in the form of distance learning of foreign languages, this article offers the main ways and methods of teaching a foreign language that can be applied in international practice of teaching foreign languages remotely.

title: DOES A TEXT KEEP BEING A TEXT? (ROUND TABLE)

title: Features of a course of pregnancy at bronchial asthma and influence of immunological deposits on a placentary barrier
abstract: Studying of features of a course of pregnancy at the bronchial asthma (BA) and influence of immunological deposits on a placentary barrier was a research objective. Results of this research testify that the main complications of pregnancy at women with bronchial asthma is pregnancy interruption threat, gestosis and placentary insufficiency. Prevention, timely identification of these complications, joint maintaining patients by the obstetrician and pulmonologist allow women practically in all cases to give birth to the full term healthy children. The greatest number of the immune deposits fixed in a placenta and damaging structures of a placentary barrier (endoteliya of vessels and a membrane of a sintsitiotrofoblast) is found in women with an average and a heavy current BA. Their adjournment is followed by morphological features of an immune inflammation, violation of an immune homeostasis in structures of a placentary barrier. Existence of pathogenic immune complexes in a placenta, and also detection with BA leads an antigen presenting cells of cages in places of an immune inflammation at women to development of immunopathological process and placentary insufficiency that adversely affects the course of pregnancy, childbirth and can be a predictive factor of development of allergic diseases in the child.

title: ANALIZ OSVEDOMLENNOSTI VRAChEI FUNKTsIONAL'NOI DIAGNOSTIKI OB ORGANIZATsII MEDITsINSKOI POMOShchI BOL'NYM EPILEPSIEI V KRASNOIaRSKOM KRAE (PILOTNOE ISSLEDOVANIE)
abstract: In Russia, as well as around the world, has been an increase in chronic diseases and disabilities. In this pilot study, we attempted to analyze the awareness of doctors on the organization of medical care for patients with epilepsy in the Krasnoyarsk region and to outline ways to improve the organization of care in patients with epilepsy from the perspective of human oriented medicine. The study revealed weaknesses in the provision of antiepileptic care as care for chronic patients. Medical care is not always the complex, as well as poorly represented psychological and emotional support to patients, and integration with social services. Just shows a low level of awareness of physicians of functional diagnostics about the state of antiepileptic service of the Krasnoyarsk region.

title: Status of placental barrier of women at the influence of exogenous and endogenous factors
abstract: The aim was to study the peculiarities of the placental status of women under the influence of exogenous and endogenous factors. We performed immunohistochemical, histological and immunomorphological study of 384 samples of placenta of women with the most common conditions (asthma, smoking, metabolic syndrome and obesity) We studied the expression of immunohistochemical markers, that indicate the presence of immune inflammation in placenta CD31, CD35, CD57, CD83, alpha amylase (a Amyl) and melatonin receptor 1B (Rc M 1B) identified C3 complement fraction, fibrinogen, IL 4, IL 6, IL 10, IgA, IgM, IgG. The largest number of immune deposits, fixed in the placenta that damage the the placental barrier (endothelium of vessels of chorionic villi and basal membrane of syncytiotrophoblast) were found in cases of moderate and severe asthma, in cases of who smoked throughout the pregnancy and was more common in cases with metabolic syndrome, while compared with obesity group. We had shown that various antigenic factors influencing on the pregnant woman revealed a similar pathogenetic impact of the pathogenic immune complex (PIC) on the membrane structures of the placenta. Destruction of the membrane structures of placental barrier at the areas of PIC leads to dystrophic and necrotic lesions of the placenta and impaired immune homeostasis, development of immunopathological process and placental insufficiency, which correlates with pregnancy and labour complications, and may be predictors of the possible development of allergic diseases in childhood.