Query: using skin picture to detect food intolerance

title: The Clinical Application Value of Multiple Combination Food Intolerance Testing
abstract: We aimed to investigate the clinical value of detecting 14 food intolerances.  A total of 312 patients with food intolerance enrolled in the Third Affiliated Hospital of Qiqihar Medical University (Qiqihar, China) from Feb 2016 to Feb 2017 were selected. ELISA was used to detect intolerance specific IgG antibodies for 14 foods (pork, chicken, beef, shrimp, fish, crab, egg white/yolk, tomato, mushroom, milk, corn, rice, soybean, wheat)  The highest average positive rate of the patients was 42.31% for the crab, followed by shrimp 21.15% egg white/yolk 18.27% and milk 16.99% The positive rate from high to low was crab, shrimp, egg white/yolk, milk, fish, corn, soybeans, tomatoes, rice, mushrooms, wheat, pork, beef, chicken. There were significant differences in the specific IgG antibody positive rates between shrimp, soybean and wheat in the skin symptoms group, gastrointestinal symptoms group, respiratory symptom group and nervous system symptom group (P<0.05) There was a significant difference in the positive rate of specific IgG antibodies between shrimp, crab and egg white/yolk in the adolescent group, the middle aged group and the elderly group (P<0.05)  The detection of food specific IgG antibodies can help to determine which food intolerance caused the disease, and then adopt a fasting or diet method to avoid eating unsuitable foods and continually damaging the body, thus maintaining good health. The detection method provides a new idea for the diagnosis and prevention of diseases.

title: An example of what Macedonian population knows about food allergies and food intolerance
abstract: A food allergy is a widespread disease, an exaggerated immune system response mostly to a food proteins, mediated by Ig E antibodies, followed by a certain clinical picture ranging from a mild to life threatening symptoms. Eight foods cause 90% of allergies: milk, egg, peanuts, tree nuts, fish, shell fish, wheat and soy. However, any food can cause an allergic reaction. Food intolerance is an adverse reaction to food that does not involve the immune system. A pilot study to detect what Macedonians know about food allergies and intolerance. A Questionnaire composed of 12 questions was put on Faculty of Technology and Technical Sciences website and answers of 130 persons from different regions of Macedonia were collected. The participants were categorized by sex and age (from 18 to 29; 30 39; and over 40) The results obtained by arithmetical mean and expressed in percentage were analyzed. 63% of them know what kind of food can often cause an allergy, 60% know about the symptoms, 73% know that allergy can be fatal, 66% does not know how to prevent the symptoms, 69% think that food allergy does not disappear throughout the life, 87% do read the declaration of the food product they are buying, 79% think that the food products are not properly labeled for allergic substances, 53% do not know the intolerance symptoms and 70% do not know how to protect themselves from food intolerance. Macedonians are quite well informed about food allergies, their symptoms and fatal outcome, but are less informed about its prevention as well as about food intolerance. There should be more sufficient labeling of all allergic substances on the food products in Macedonia. A wider population should be included in the survey to confirm these findings.

title: Association of Food Intolerance with Coronary Artery Disease
abstract: Hippocrates wisely said that <your food be your medicine and that nature is the doctor of diseases> In the Holy Scriptures the <clean from the unclean foods> are separated. In this pilot study, we tried to uncover any intolerances to foods of patients with coronary artery disease.  The purpose of this trial was to evaluate any food categories that stimulate the immune system of patients with coronary heart disease by creating a vicious circle of inflammation, including atherogenesis. The analysis will contribute to possibly understand patients with coronary artery disease, the aetiopathogenesis of the underlying disease and implement the appropriate therapeutic nutrition.  The presence of IgG antibodies were detected using a kit (Golden test) with ELISA method in 63 patients and 12 healthy individuals.  The analysis revealed that more frequent intolerances were in banana, milk products and eggs. The tests showed statistical differences for banana and milk among the two groups.  Although most patients had an intolerance in bananas, eggs and milk, this work does not verify the association of food intolerances with the etiology of coronary artery disease.

title: Food allergy and food intolerance knowledge of foodservice workers in Hungarian schools
abstract: To provide food for children with food allergy or food intolerances represents an increasingly important role in school catering services. The number of children with food intolerances is growing continuously; therefore, it is necessary to improve the knowledge of foodservice workers, who are responsible for food provision in school catering units in relation with food intolerances, food allergies. The main goal of our research is to assess and analyze the knowledge of food service workers and food handlers on food intolerances and to determine those factors, which may influence their knowledge. Our research was conducted by using paper and pencil questionnaires. The mean of test results was 89,16% while deviation was 12,26% There were no correlations between the test results and respondents' education level, age group and the number of years working in food catering sector, and only partial correlation was detected with the job of the respondents. Based on the answers the food handling techniques of diet foods represented the poorest results. Our findings proved that the knowledge and food handling practice of food handlers regarding food intolerances and the preparation of diet meals should be improved.

title: Diagnosis of Feline Food Sensitivity and Intolerance Using Saliva: 1000 Cases
abstract: This study asked whether a novel saliva based diagnostic test could predict food sensitivities and intolerances in cats. Clinical samples were obtained from 1000 cats proven or suspected to have adverse food reactions (AFR) Most were domestic shorthairs over 10 years old and weighed around 5 kg; they were equally distributed between spayed females and neutered males. Saliva was collected after at least an 8 h fast with a dental cotton rope, placed in a special saliva collection tube, and sent to the laboratory. Salivary reactions to 24 common foods were measured with immunological reagents. Low reacting foods were lamb, cow milk, pork, turkey, wheat (lowest) and white colored fish, whereas high reacting foods were millet, white potato, rice (highest) and salmon. Thus, this novel salivary based food sensitivity and intolerance test, described previously for dogs, also provided a reliable and clinically predictive alternative to other methods of measuring AFR in cats.  This prospective study assessed the efficacy of a novel saliva based immunoassay of IgA and IgM antibodies in predicting feline food sensitivities and intolerances. Clinical samples were obtained from 1000 cats proven or suspected to have food intolerances. Most were of domestic shorthair breed type, over 10 years of age, and weighed around 5 kg; they were equally distributed between spayed females and neutered males. Saliva was collected after at least an 8 h fast with a dental cotton rope, placed in a double sleeved saliva collection tube, and sent to the laboratory. Salivary antibodies elicited by 24 common foods were measured with goat anti canine IgA and IgM. Low reacting foods were lamb, cow milk, pork, turkey, wheat (lowest) and white colored fish, whereas high reacting foods were millet, white potato, rice (highest) and salmon. Thus, the novel salivary based food sensitivity and intolerance test, described previously for canines, also provided a reliable and clinically predictive alternative to food elimination trials, serum based food allergy testing, and skin patch testing in cats. Manufacturers of commercial cat foods and treats, as well as those making homemade diets and treats for cats, should consider avoiding the more highly reactive foods as determined by the present study.

title: IRRITABLE BOWEL SYNDROME, FOOD INTOLERANCE AND NON CELIAC GLUTEN SENSITIVITY. A NEW CLINICAL CHALLENGE.
abstract: Approximately 80% of irritable bowel syndrome (IBS) patients report that their symptoms are triggered after ingesting one or specific food groups. Gluten, wheat and related proteins (e.g. amylase trypsin inhibitors, and fermentable oligo di mono saccharides and polyols (FODMAPs) are the most relevant IBS symptom triggers, although the true 'culprit(s) is/are still not well established. The concept of causal relationship between gluten intake and the occurrence of symptoms in the absence of celiac disease and wheat allergy was termed non celiac gluten sensitivity (NCGS) The borderline between celiac disease, wheat allergy, IBS and NCGS is not always clearly distinguishable, and the frequency and clinical identity of NGCS are still unclear. An overlap between IBS and NCGS has been detected. The incomplete knowledge of the etiopathogenesis of these clinical conditions, lack of data on their real epidemiology, as well as the absence of a gold standard for their diagnosis, make the overall picture difficult to understand "It is crucial to well define the interaction between IBS, food intolerance and NGCS, since the role of diet in IBS and its dietary management is an essential tool in the treatment of a large number of these patients" The objective of the present review is to provide an overview highlighting the interaction between IBS, food intolerance and NCGS in order to unravel whether gluten/wheat/FODMAP sensitivity represents 'facts' and not 'fiction' in IBS symptoms.

title: Diagnosis of Canine Food Sensitivity and Intolerance Using Saliva Report of Outcomes
abstract: To assess the efficacy of a novel saliva based immunoassay of IgA and IgM antibodies in predicting canine food sensitivity and intolerance.  Prospective controlled and clinical trial cohort populations. Animals Greyhounds from a closed colony, both healthy (n=29) and with inflammatory bowel disease (IBD) (n=10) clinical samples from dogs of various breeds and mixed breeds, classified as healthy without evidence of IBD (n=208) clinically suspected IBD (n=289) and proven IBD (n=98) cases. Second cohort of clinical samples from dogs suspected to have IBD (n=1008) Procedures Saliva was collected with a dental cotton rope from dogs that had not eaten for at least 8 hrs, placed in a double sleeved saliva collection tube, and transported to the laboratory. Salivary antibodies elicited by 24 foods were measured with goat anti canine IgA and IgM.  Data distinguished healthy, suspect, and proven IBD cases among Greyhounds and 2 large canine clinical case cohorts. Results were stratified as negative, and as intermediate, medium, and strong reactors against 1 or more of the food antigens tested. The 1 4 year and over 10 year age groups had the highest number of positive food reactors, and the German Shepherd Dog was most represented. Clinical outcome comparisons after eliminating reactive foods (n=50) and follow up saliva re testing (n=15) demonstrated the clinical accuracy and predictive outcome of this test.  The novel salivary based food sensitivity and intolerance test described here for canines offers a reliable and clinically predictive alternative to food elimination trials, serum based food allergy testing, and skin patch testing.  The background and rationale for a novel approach to diagnosis of canine food sensitivity and intolerance using saliva was recently published (1) (a) Basically, delayed, latent, or pre clinical elaboration of IgA and/or IgM antibodies to specific food antigens can be detected in mucosal fluids such as saliva, feces, sweat, and tears (2 6) These antibodies to foods appear in the mucosal biofluids before the clinical or gastrointestinal (GI) tract biopsy diagnosis is made of intestinal biopsy confirmed inflammatory bowel disease (IBD) and/or or "leaky gut syndrome." A major cause of the leaky gut is known to stem from release of zonulin which physiologically modulates intestinal barrier function and serves as a biomarker of impaired gut function (2 6) Zonulin release is triggered primarily by the gliadin protein of dietary glutens and gut bacteria in the small intestine, thereby creating gradients for the optimal transport of nutrients and balancing the body's tolerance or immunity to Diagnosis of Canine Food Sensitivity and Intolerance Using Saliva: Report of Outcomes W. Jean Dodds, DVM Hemopet, 11561 Salinaz Avenue, Garden Grove, CA 92843; Phone: 714 891 2022, ext. 115; Fax: 714 891 2123;

title: Beyond gluten: role of FODMAPs and other wheat proteins as triggers of symptoms in food intolerance
abstract: Foods are known to be symptom trigger in a large number of patients. Although the underlying mechanisms are still far from being elucidated, the increasing number of patients presenting with a clinical picture suggestive of food intolerance has recently caught physicians' attention. This review is intended to focus on clinical, diagnostic and therapeutic aspects of food intolerance such as those elicited by wheat/ gluten (non celiac wheat/gluten sensitivity, NCW/GS) and fermentable oligo di mono saccharides and polyols (FODMAPs) NCW/GS is a syndrome characterized by gastrointestinal (e.g. bloating, abdominal pain and bowel habit changes) and extraintestinal (e.g. headache, skin rashes and fibromyalgia like) symptoms related to the ingestion of gluten containing foods in subjects testing negative for celiac disease and/or wheat allergy. Symptoms improve/ disappear after gluten free diet and recur with gluten challenge. Functional bowel symptoms overlapping those of NCW/GS are also evoked by FODMAPs and wheat proteins (e.g. amylase trypsin inhibitors) So far, there are no biomarkers for NCW/GS, although 50% of patients display IgG anti gliadin antibodies. A double blind, placebo controlled food challenge is currently the only way to confirm the diagnosis of NCW/GS. There are no controlled trials to prove actual efficacy of low FODMAPs diet vs placebo. Studies are eagerly awaited to shed light on dietary changes as measure to be used in patients with food sensitivity and related gut symptoms.

title: Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis.
abstract: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC)  To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity.  A cross sectional multicenter study was done in two tertiary centers for allergy in Iran. Adult patients with NP were selected for the study that had been referred to allergy clinics. The oral aspirin challenge (OAC) test was performed to identify aspirin exacerbated respiratory disease (AERD) and the OFC test was used to investigate food intolerance. Atopic evaluation was performed by skin prick tests, nasal smear and blood eosinophil count as well as serum total IgE.  One hundred and nineteen Iranian patients (female to male ratio 1.05) with NP were enrolled (mean age, 38 11 years) Recurrence of nasal polyposis was 64.7% OAC was performed in all cases; 43.79% cases had aspirin hypersensitivity. In addition, OFC tests determined that 69.9% of patients had salicylate food allergy. Salicylate food intolerance was significantly higher in NP cases with AERD than in aspirin tolerant patients (p<0.05) Yet, positive skin prick test was not associated with NP recurrence and AERD.  Atopy and NSAID exacerbated respiratory disease; therefore, they can both be considered as predictors of NP recurrence. Our study also showed that salicylate food intolerance was associated with AERD in nasal polyposis.

title: Pattern of food intolerance in patients with gastro esophageal reflux symptoms.
abstract: Many food items have been involved in gastro esophageal reflux disease pathogenesis and dietary modification has been proposed as first line treatment. Test based exclusion diets have shown to significantly reduce reflux symptoms. We aimed to assess the patterns of food intolerance in a series of patients with typical gastro esophageal reflux symptoms (GERS) METHODS We retrospectively evaluated all patients with typical reflux symptoms, attending the Centre Study Association on Food Intolerance and Nutrition of Ferrara from January 2010 to October 2015, who resulted positive to at least one food item at the Leucocytotoxic Test. The presence and severity of typical GERS (heartburn and/or acid regurgitation) were assessed using the Gastro esophageal Reflux Disease Impact Scale (GIS) questionnaire. Only individuals with a GIS Score of at least 5 points were included.  Almost all patients (91.1% were intolerant to at least 5 food items. The most frequent food intolerance (more than 33% of patients) were found for milk (55.4% lettuce (46.4% coffee (43.7% brewer's yeast (42.9% pork (42.9% tuna (37.5% rice (35.7% sole (34.8% asparagus (34.8% and eggs (33.9% Nine different clusters of food intolerance were detected.  Patients with typical gastro esophageal reflux symptoms seem to have intolerance to multiple food items, some of which (lettuce, brewer's yeast, tuna, rice, sole and asparagus) have not yet been associated to gastro esophageal reflux disease.