Query: visceral spasm

title: Quantitative determination of the visceral pain threshold in man; characteristics of visceral pain, effect of inflammation and analgesics on the threshold, and relationship of analgesia to visceral spasm.

title: Diffuse esophageal spasm and detrusor spasm: Combined visceral neuromuscular disorders in a patient with William's Syndrome
abstract: William's Syndrome is a rare genetic disorder associated with developmental delay, gregarious personality, characteristic facies, multiple medical complications and valvular heart disease. Urologic and gastrointestinal complications including motor abnormalities and diverticulosis of the bladder and colon are commonly present. We present a case of a 37 year old male with William's Syndrome who originally demonstrated typical bladder and bowel dysfunction associated with the condition, but also later developed severe dysphagia and associated weight loss. An esophagram revealed the presence of three large distal (epiphrenic) esophageal diverticula. These are most often caused by the presence of an underlying esophageal motility disorder. High resolution esophageal manometry was performed and showed multiple simultaneous contractions and non propagated contractions with swallowing maneuvers, consistent with the diagnosis of diffuse esophageal spasm (DES) This is the first case of an esophageal motor disorder described in a patient with William's Syndrome and supports the concept that there is a generalized visceral neuromuscular dysfunction present in these patients.

title: Spastic Achalasia and Detrusor Spasm: Combined Visceral Neuromuscular Disorders in a Patient with William's Syndrome: 643

title: ON THE DIVISION OF THE POSTERIOR SPINAL NERVE ROOTS: (I. FOR PAIN (II. FOR VISCERAL CRISES (III. FOR SPASM.1

title: On the Division of the Posterior Spinal Nerve Roots: (I) for Pain, (II) for Visceral Crises, (III) for Spasm

title: On the Division of the Posterior Spinal Nerve roots: (I) for Pain, (II) for Visceral Crises, (III) for Spasm: An Address Introductory to a Discussion on the Subject.

title: Relationship between epicardial adipose tissue volume and coronary artery spasm.
abstract: Epicardial adipose tissue (EAT) is considered to play a critical role in vascular endothelial function. Coronary artery spasm has been postulated to be a causal factor in vascular endothelial abnormalities and atherosclerosis. This study aimed to investigate the relationship between coronary artery spasm and EAT volume, total abdominal adipose tissue (AAT) area, and abdominal visceral adipose tissue (AVAT) area.  Among patients undergoing coronary computed tomography (CT) to evaluate coronary artery disease, we identified 110 patients who did not have significant coronary artery stenosis and underwent a coronary spasm provocation test with cardiac catheterization. They were divided into two groups according to the results of the spasm provocation test: spasm positive and spasm negative. EAT volume, total AAT area, and AVAT area were evaluated using CT images.  Seventy seven patients were included in the spasm positive group and 33 patients in the spasm negative group. There were no significant differences in baseline clinical characteristics between the two groups, except for the prevalence of current smoking (48% vs. 27% p 0.04) EAT volume was significantly higher in the spasm positive group (108 38 mL vs. 87 34 mL, p 0.007) while no significant difference was seen in total AAT area (280 113 cm2 vs. 254 128 cm2, p 0.32) or AVAT area (112 54 cm2 vs. 98 55 cm2, p 0.27) Multivariate logistic analysis indicated that EAT volume (per 10 cm3) (odds ratio, 1.198; 95% confidence interval, 1.035 1.388; p 0.016) was a significant predictor of coronary artery spasm.  Our results suggest that EAT has a strong association with coronary artery spasm, while AAT may not.

title: FMRP acts as a key messenger for visceral pain modulation
abstract: Visceral pain is a common clinical symptom, which is caused by mechanical stretch, spasm, ischemia and inflammation. Fragile X syndrome (FXS) with lack of fragile X mental retardation protein (FMRP) protein is an inherited disorder that is characterized by moderate or severe intellectual and developmental disabilities. Previous studies reported that FXS patients have self injurious behavior, which may be associated with deficits in nociceptive sensitization. However, the role of FMRP in visceral pain is still unclear. In this study, the FMR1 knock out (KO) mice and SH SY5Y cell line were employed to demonstrate the role of FMRP in the regulation of visceral pain. The data showed that FMR1 KO mice were insensitive to zymosan treatment. Recording in the anterior cingulate cortex (ACC) a structure involved in pain process, showed less presynaptic glutamate release and postsynaptic responses in the FMR1 KO mice as compared to the wild type (WT) mice after zymosan injection. Zymosan treatment caused enhancements of adenylyl cyclase 1 (AC1) a pain related enzyme, and NMDA GluN2B receptor in the ACC. However, these up regulations were attenuated in the ACC of FMR1 KO mice. Last, we found that zymosan treatment led to increase of FMRP levels in the ACC. These results were further confirmed in SH SY5Y cells in vitro. Our findings demonstrate that FMRP is required for NMDA GluN2B and AC1 upregulation, and GluN2B/AC1/FMRP forms a positive feedback loop to modulate visceral pain.

title: PJ 675 Abdominal Visceral Fat is Associated with not only Arteriosclerosis, but also Coronary Artery Spasm(Diabetes Obesity Metabolic syndrome(13)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

title: The Role of the Splanchnics in the Adductor Spasm of the Vocal Cords Following Visceral Traction.