Query: evaluation of corona virus

title: Effect evaluation of perioperative management strategy for the elderly with hip fractures during pandemic of corona virus disease 2019/ Xin Xing Guan Zhuang Bing Du Fei Yan Yi Qing Qi Jian Lao Nian Kuan Bu Gu Zhe Huan Zhe Wei Zhu Qi Guan Li Ji Xiao Guo Ping Jie
abstract: To explore the perioperative management strategy for the elderly with hip fractures during the epidemic of corona virus disease 2019 (COVID 19) and evaluate its clinical effect  A retrospective case series study was conducted on 33 elderly patients with hip fractures admitted to Chongqing General Hospital, University of Chinese Academy of Sciences, from January 20 to February 29, 2020, including 14 males and 19 females, aged 65 92 years (76 5+ 6 3) years] There were 20 patients with intertrochanteric fractures and 14 with femoral neck fractures In total, 15 patients were combined with hypertension and 9 with diabetes A total of 19 patients were treated with open reduction and internal fixation and 14 with total hip/semi hip replacement The time from injury to admission was 2 14 hours The temperature measurement, routine blood test and chest CT examination were performed to exclude COVID 19 in all patients, which showed 12 patients with pulmonary infection The medical staff received different levels of protection: first level protection for those in the special ward, secondary level protection for the emergency isolation ward and tertiary level protection for those collecting the throat swab samples The time from admission to operation, intensive care unit (ICU) stay time, hospitalization time, visual analogue score (VAS) perioperative complications as well as infection of patients and medical staff were observed and recorded  The time from admission to operation was (3 18+ 0 19) days for all patients, with (2 24+ 0 28) days for 21 patients with no obvious pulmonary abnormality and (4 83+ 0 39) days for 12 with pulmonary infection The hospitalization time was (10 97+ 0 31) days in all patients, with (9 71+ 0 27) days for 21 patients with no obvious pulmonary abnormality and (12 51+ 0 78) days for 12 with pulmonary infection After operation, 12 patients were treated in ICU for 1 3 days, and the rest 21 patients were treated in general wards The pain of all patients was effectively controlled The time for exercise was (4 0+ 1 4) days after operation in all patients, among which 19 treated with fracture reduction and internal fixation started at (4 3+ 1 3) days after operation and 14 treated with total hip/semi hip replacement started at (3 6+ 1 3) days after operation VAS was (4 55+ 0 29) points at 12 hours before operation, (5 62+ 1 12) points at 6 hours, (3 54+ 0 39) points at 24 hours, and (2 42+ 0 11) points at 72 hours after operation (P<0 05) Chest CT showed that the pulmonary inflammation was significantly improved one day before discharge There was no indication of nucleic acid detection, with no urinary tract infection, pressure sore, deep vein thrombosis or other complications were found No infection of patients or medical staff occurred  During pandemic of COVID 19, early surgical treatment for the elderly with hip fractures can be done in the general wards, based on strictly following the principle of infection prevention and control and carefully evaluating the perioperative risks, which can avoid the probability of infection of patients and medical staff without prolonging the hospitalization time or increasing the incidence of complications

title: Impact of Corona Virus A Statistical Evaluation
abstract: The field of health science accumulates large amounts of data with diverse and correlated attributes Processing such type of data requires specialized techniques Data analytics techniques are suitable for that purpose Statistical evaluation is an important step for understanding health data In the current scenario of the outbreak of novel Corona Virus (COVID 19) we have utilized the Novel Corona Virus 2019 data collected by John Hopkins University to extract important and interesting insights A complete analytical study comprising of exploratory analysis, time series analysis and geographical analysis has been attempted so as to assess the impact and spread of the virus in most affected countries like China and also the remaining world The resulting insights would help the public, governments and the research community to understand the gravity of the situation and take remedial measures The entire analysis has been carried out in R (c) 2020

title: Evaluation of technology based learning by dental students during the pandemic outbreak of Corona virus disease 2019
abstract: Although technology based learning (TB learning) has been accepted as an efficient educational tool in the field of dentistry, evaluation of TB learning in non prepared situations such as pandemics has not been fully investigated. This study aimed to evaluate different aspects of TB learning among undergraduate dental students during the pandemic outbreak of COVID 19.  Dental students in selected Iraqi universities (University of Baghdad, University of Sulaimani, and Dijlah University College) were invited to join the study. A questionnaire was created using a Google platform and answered by students. Satisfaction and attitude toward TB learning plus total evaluation scores for lecturers were examined.  A total of 832 out of 1800 dental students participated in the study. The majority of participants have basic (40.7% and intermediate (47.5% computer skills and more than half of them lack any experience in TB learning. The overall satisfaction and positive attitude toward TB learning was less than 50% Students at final grade, with advanced computer skills and TB learning experience showed higher satisfaction (OR: 3.031, 2.876, 3.644, respectively) and a more positive attitude (OR: 3.172, 3.035, 3.477, respectively) toward TB learning than those at earlier grades. Total evaluation scores for lecturers were higher among females (11.5+ 5.8) than males (9.9+ 7.2) as well as among participants at final grade (14.0+ 6.2) with advanced computer skills (13.8+ 6.1) and TB learning experience (16.2+ 6.0)  Dental students demonstrated low moderate satisfaction and positive attitude toward TB learning and the quality of material presented to them. Integrating TB learning into the dental education curriculum is an essential step in enhancing the acceptance of TB learning in the future.

title: Effectiveness evaluation ofapplyingan intelligent voice callsystem on the popular science knowledge of Corona Virus Disease 2019 for the patients with chronic diseases in the community
abstract: To improve the contracted patients'cognitive level and self protection ability ofCorona Virus Disease 2019 (COVID 19)through the popularizationeducation with the application of an intelligent voice outbound system.  12 popular science education modules ware designed according to the knowledge and protective measures ofCOVID 19, and3 6 core points were extracted from each module. From Wuhan city blocked 2020.1.23 to 2020.1.29, the intelligent voice outbound system was applied toperform batch voice call calls and send text messages to all contracted patients with chronic diseases in different period of time for popular science education.Using equidistant sampling method, 400 cases were successfully selectedfrom the patients of successful voice outbound calls.The intelligent voice outbound system was used to investigatepatients' mastery, the main sources ofCOVID 19knowledge, and satisfaction with popular science education conducted in this study. The outbound results of the above indicators were queried from the database of the intelligent voice outbound system.  A total of 98,487 voice outbound calls were effectively connected,the average call duration per person was 2.24 minutes, and the total call durationwas equivalent to 488.5 workdays. 141,201 messages were sent, with a read rate of 97.8% (141 201/144 405) The patients'scoreto answer the popular science knowledge questionnaire was 86.8+ 16.7.94.8% (235/248) of patients'knowledge of COVID 19mainly came from voice call.In addition, the patient's overall satisfaction with the application of the intelligent voice call system for popular science education was90.8%(225/248)  The patients'cognitive levelofCOVID 19knowledge and its prevention and control measureseffectively improved with the application of an intelligent voice outbound system. Moreover, this mode was highly acceptable to patients, whichshould be referenced by other urban communities in China.  Corona Virus Disease 2019 (COVID 19) Community; Intelligence; Voice callsystem; Healthy education

title: Evaluation of green tea polyphenols as novel corona virus (SARS CoV 2) main protease (Mpro) inhibitors an in silico docking and molecular dynamics simulation study
abstract: Coronavirus disease 2019 (COVID 19) is a viral respiratory disease which caused global health emergency and announced as pandemic disease by World Health Organization. Lack of specific drug molecules or treatment strategy against this disease makes it more devastating. Thus, there is an urgent need of effective drug molecules to fight against COVID 19. The main protease (Mpro) of SARS CoV 2, a key component of this viral replication, is considered as a prime target for anti COVID 19 drug development. In order to find potent Mpro inhibitors, we have selected eight polyphenols from green tea, as these are already known to exert antiviral activity against many RNA viruses. We have elucidated the binding affinities and binding modes between these polyphenols including a well known Mpro inhibitor N3 (having binding affinity 7.0 kcal/mol) and Mpro using molecular docking studies. All eight polyphenols exhibit good binding affinity toward Mpro 7.1 to 9.0 kcal/mol) However, only three polyphenols (epigallocatechin gallate, epicatechingallate and gallocatechin 3 gallate) interact strongly with one or both catalytic residues (His41 and Cys145) of Mpro. Molecular dynamics simulations (100 ns) on these three Mpro polyphenol systems further reveal that these complexes are highly stable, experience less conformational fluctuations and share similar degree of compactness. Estimation of total number of intermolecular H bond and MM GBSA analysis affirm the stability of these three Mpro polyphenol complexes. Pharmacokinetic analysis additionally suggested that these polyphenols possess favorable drug likeness characteristics. Altogether, our study shows that these three polyphenols can be used as potential inhibitors against SARS CoV 2 Mpro and are promising drug candidates for COVID 19 treatment.

title: [Construction and evaluation of a novel diagnosis process for 2019 Corona Virus Disease]
abstract: To construct and evaluate a diagnosis process for 2019 Corona Virus Disease (COVID 19) Methods: A continuous cohort of adults and adolescent =12 years) who screened COVID 19 was included in Xiangya Hospital of Central South University from January 23 to February 3, 2020 in which cases were divided the test library and the verification library. Their gender, age, onset time were recorded. Take epidemiological history, fever, and the blood lymphocytes decline as clinical indicators, used CT to evaluate the possibility of COVID 19 and range of lung involvement. According to the current national standards, throat swabs of suspected cases were collected and the nucleic acid of COVID 19 was detected by reverse transcription polymerase chain reaction (RT PCR) The Xiangya process was constructed according to multi index, compared with clinical indicators, CT results and national standards, the efficiency of detecting confirmed cases were verified in the test and verification library.  A continuous cohort of 382 adults who screened COVID 19 was included in which 261 cases were in the test library and 121 cases were in the verification library. In the 382 cases, 192 were males (50.3% and 190 were females (49.7% with a median age of 35 years (range: 15 92 years) There were 183 cases (47.9% with epidemiological history, 275 cases (72.0% with fever, 212 cases (55.5% with decreased hemolytic lymphocytes, CT positive 114 cases (29.8% 43 cases (11.3% with positive CT COVID 19, and 30 cases (7.9% with positive throat swab nucleic acid. Compared with clinical indicators, the sensitivity and specificity of CT were 0.950 and 0.704, respectively. The accuracy of CT to make a definite diagnosis was higher than that of epidemiological history, fever, and blood lymph count decline (0.809 vs 0.660, 0.532, 0.596, P=0.001, 0.002, 0.003, respectively) The sensitivity of this process and the program recommended by the Health Commission all were high (all were 1.000) and the specificity and accuracy of the process were higher than the program recommended by the Health Commission (0.872 vs 0.765, 0.778 vs 0.592, both P<0.001) The CT COVID 19 would have reduced the missed diagnosis rate caused by false negative of nucleic acid test (31 vs 64, difference rate 51.6% the positive rate of nucleic acid test was 64.5% (20/31) In validation library, the specificity and accuracy of the Xiangya process was 0.967, the positive rate of nucleic acid test was 76.9% (10/13)  The Xiangya process can predict the nucleic acid test results of COVID 19 well, and can be applied as a reliable basis for confirmed cases detection in adults and adolescent =12 years) in areas other than Hubei during the epidemic period of COVID 19. The cohort size needs to be increased for further validation.

title: [Detection and evaluation of SARS CoV 2 nucleic acid contamination in corona virus disease 19 ward surroundings and the surface of medical staff's protective equipment]
abstract: To determine the environmental contamination degree of severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) in corona virus disease 2019 (COVID 19) wards, to offer gui dance for the infection control and to improve safety practices for medical staff, by sampling and detecting SARS CoV 2 nucleic acid from the air of hospital wards, the high frequency contact surfaces in the contaminated area and the surfaces of medical staff's protective equipment in a COVID 19 designated hospital in Wuhan, China.  From March 11 to March 19, 2020, we collected air samples from the clean area, the buffer room and the contaminated area respectively in the COVID 19 wards using a portable bioaerosol concentrator WA 15. And sterile premoistened swabs were used to sample the high frequency contacted surfaces in the contaminated area and the surfaces of medical staff's protective equipment including outermost gloves, tracheotomy operator's positive pressure respiratory protective hood and isolation clothing. The SARS CoV 2 nucleic acid of the samples were detected by real time fluorescence quantitative PCR. During the isolation medical observation period, those medical staff who worked in the COVID 19 wards were detected for SARS CoV 2 nucleic acid with oropharyngeal swabs, IgM and IgG antibody in the sera, and chest CT scans to confirm the infection status of COVID 19.  No SARS CoV 2 nucleic acid was detected in the tested samples, including the 90 air samples from the COVID 19 wards including clean area, buffer room and contaminated area, the 38 high frequency contact surfaces samples of the contaminated area and 16 surface samples of medical staff's protective equipment including outermost gloves and isolation clothing. Moreover, detection of SARS CoV 2 nucleic acid by oropharyngeal swabs and IgM, IgG antibodies in the sera of all the health care workers who participated in the treatment for COVID 19 were all negative. Besides, no chest CT scan images of medical staff exhibited COVID 19 lung presentations.  Good ventilation conditions, strict disinfection of environmental facilities in hospital wards, guidance for correct habits in patients, and strict hand hygiene during medical staff are important to reduce the formation of viral aerosols, cut down the aerosol load, and avoid cross infection in isolation wards. In the face of infectious diseases that were not fully mastered but ma naged as class A, it is safe for medical personnel to be equipped at a high level.

title: Evaluation of the treatment effect of 9 confirmed Corona Virus Disease 2019 cases in Gansu Province/ Gan Su Sheng 9 Li Xin Xing Guan Zhuang Bing Du Fei Yan Que Zhen Bing Li Jiu Zhi Xiao Guo Ping Jie
abstract: To study the epidemiological and clinical features and treatment strategies for Corona Virus Disease 2019 (COVID 19) in Gansu Province, and to evaluate the effect of treatment  The 9 patients with COVID 19 admitted in Lanzhou Pulmonary Hospital were used as the research object, their epidemiological history, clinical symptoms, head imaging and treatment methods were collected Results Except for 1 patient who died, 7 patients were cured and discharged, 1 patient was still receiving treatment due to the continuous positive pharyngeal swab nucleic acid test  Although only chest imaging can not be used as an indicator to assess the release from isolation, it can be used to judge whether the patient's disease is progressing Because no clear antiviral drugs are currently available, the use of lopinavir and ritonavir might be effective against COVID 19 In addition, early detection of patients is the most effective way to control the epidemic at present

title: FUZZY EVALUATION OF IMPACT OF LOCKDOWN AMID CORONA VIRUS ON DELHI'S POLLUTION
abstract: The outbreak of novel Corona virus has been stated as a pandemic by World Health Organisation The World Health Organisation enunciates to all of the countries in the world to continue efforts that have been effective in limiting the number of cases and slow down the spread of the virus Social distancing has been addressed as the most effective measure of mitigation In this direction to suppress social contact, India is under a three week lockdown with around 130 crore people urged to stay in their homes With rigorous travel restrictions along with shutting down of almost all of the non essential activities there has been observed a drastic reduction in air pollution in all of the major cities The present study aimed to interpret the dip in air pollution of Delhi For this analysis, Fuzzy Inference System of MATLAB has been employed The simulation results shows a drastic fall in air pollutants PM2 5, PM10 and NO2 levels at all of the sampling sites This study highlights the impact of lockdown on pollution level along with a suggestion to the government to implement a one day lockdown in 3 4 months to put a check on pollution Mother Nature is expecting from us through present crisis to reciprocate perfectively and positively (c) 2020,

title: Going beyond clinical routine in SARS CoV 2 antibody testing A multiplex corona virus antibody test for the evaluation of cross reactivity to endemic coronavirus antigens
abstract: Given the importance of the humoral immune response to SARS CoV 2 as a global benchmark for immunity, a detailed analysis is needed to (i) monitor seroconversion in the general population, (ii) understand manifestation and progression of the disease, and (iii) predict the outcome of vaccine development. Currently available serological assays utilize single analyte technologies such as ELISA to measure antibodies against SARS CoV 2 antigens including spike (S) or nucleocapsid (N) protein. To measure individual antibody (IgG and IgA) responses against SARS CoV 2 and the endemic human coronaviruses (hCoVs) NL63, 229E, OC43, and HKU1, we developed a multiplexed immunoassay (CoVi plex) for which we included S and N proteins of these coronaviruses in an expanded antigen panel. Compared to commercial in vitro diagnostic (IVD) tests our CoVi plex achieved the highest sensitivity and specificity when analyzing 310 SARS CoV 2 infected and 866 uninfected individuals. Simultaneously we see high IgG responses against hCoVs throughout all samples, whereas no consistent cross reactive IgG response patterns can be defined. In summary, our CoVi plex is highly suited to monitor vaccination studies and will facilitate epidemiologic screenings for the humoral immunity toward pandemic as well as endemic coronaviruses.