nils-herrmann/clean_scirepeval huggingface dataset:
Clinical practice guideline: red blood cell transfusion in adult trauma and critical care.

To develop a clinical practice guideline for red blood cell transfusion in adult trauma and critical care.



Meetings, teleconferences and electronic-based communication to achieve grading of the published evidence, discussion and consensus among the entire committee members.



This practice management guideline was developed by a joint taskforce of EAST (Eastern Association for Surgery of Trauma) and the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM). We performed a comprehensive literature review of the topic and graded the evidence using scientific assessment methods employed by the Canadian and U.S. Preventive Task Force (Grading of Evidence, Class I, II, III; Grading of Recommendations, Level I, II, III). A list of guideline recommendations was compiled by the members of the guidelines committees for the two societies. Following an extensive review process by external reviewers, the final guideline manuscript was reviewed and approved by the EAST Board of Directors, the Board of Regents of the ACCM and the Council of SCCM.



Key recommendations are listed by category, including (A) Indications for RBC transfusion in the general critically ill patient; (B) RBC transfusion in sepsis; (C) RBC transfusion in patients at risk for or with acute lung injury and acute respiratory distress syndrome; (D) RBC transfusion in patients with neurologic injury and diseases; (E) RBC transfusion risks; (F) Alternatives to RBC transfusion; and (G) Strategies to reduce RBC transfusion.



Evidence-based recommendations regarding the use of RBC transfusion in adult trauma and critical care will provide important information to critical care practitioners.
Improvement of a patient's circadian rhythm sleep disorders by aripiprazole was associated with stabilization of his bipolar illness.

Splitting of the behavioural activity phase has been found in nocturnal rodents with suprachiasmatic nucleus (SCN) coupling disorder. A similar phenomenon was observed in the sleep phase in the diurnal human discussed here, suggesting that there are so-called evening and morning oscillators in the SCN of humans. The present case suffered from bipolar disorder refractory to various treatments, and various circadian rhythm sleep disorders, such as delayed sleep phase, polyphasic sleep, separation of the sleep bout resembling splitting and circabidian rhythm (48 h), were found during prolonged depressive episodes with hypersomnia. Separation of sleep into evening and morning components and delayed sleep-offset (24.69-h cycle) developed when lowering and stopping the dose of aripiprazole (APZ). However, resumption of APZ improved these symptoms in 2 weeks, accompanied by improvement in the patient's depressive state. Administration of APZ may improve various circadian rhythm sleep disorders, as well as improve and prevent manic-depressive episodes, via augmentation of coupling in the SCN network.
Omega-3 fatty acids in cancer.

Significant achievements have been obtained in cancer treatment, but the clinical relevance of drug approach in daily practice remains questionable due to the high costs, limited efficacy, and negligible influence on quality of life. A new concept is emerging which is based on the early combination of chemotherapy and nutrition therapy.



Inflammation dictates tumour initiation, progression and growth. Omega-3 fatty acids exert anti-inflammatory effects, and therefore recent studies investigated their role in cancer prevention, in cancer cachexia treatment and in enhancement of antitumour therapies. Limited evidence suggests a role for omega-3 fatty acid supplementation in cancer prevention, but they have been shown to preserve muscle mass and function in cancer patients even during active treatment. During chemotherapy, omega-3 fatty acids may contribute to a reduced inflammatory response, but whether cancer treatment toxicity can be prevented remains to be assessed. Finally, small studies showed that omega-3 fatty acids increase response rate to chemotherapy.



Combination of chemotherapy and omega-3 supplementation appears an effective strategy to enhance the clinical outcome of cancer patients in their curative and palliative clinical trajectory.
Immune Escape Mechanisms in Colorectal Cancer Pathogenesis and Liver Metastasis

Over the past decade, growing evidence indicates that the tumor microenvironment (TME) contributes with genomic/epigenomic aberrations of malignant cells to enhance cancer cells survival, invasion, and dissemination. Many factors, produced or de novo synthesized by immune, stromal, or malignant cells, acting in a paracrine and autocrine fashion, remodel TME and the adaptive immune response culminating in metastasis. Taking into account the recent accomplishments in the field of immune oncology and using metastatic colorectal cancer (mCRC) as a model, we propose that the evasion of the immune surveillance and metastatic spread can be achieved through a number of mechanisms that include (a) intrinsic plasticity and adaptability of immune and malignant cells to paracrine and autocrine stimuli or genotoxic stresses; (b) alteration of positional schemes of myeloid-lineage cells, produced by factors controlling the balance between tumour-suppressing and tumour-promoting activities; (c) acquisition by cancer cells of aberrant immune-phenotypic traits (NT5E/CD73, CD68, and CD163) that enhance the interactions among TME components through the production of immune-suppressive mediators. These properties may represent the driving force of metastatic progression and thus clinically exploitable for cancer prevention and therapy. In this review we summarize results and suggest new hypotheses that favour the growing impact of tumor-infiltrating immune cells on tumour progression, metastasis, and therapy resistance.
Can Quirks of Grammar Affect the Way You Think? Grammatical Gender and Object Concepts

Can the language you speak affect the way you think? Unlike English, many languages have a grammatical gender system whereby all nouns are assigned a gender. Does talking about inanimate objects as if they were masculine or feminine actually lead people to think of inanimate objects as having a gender? A series of studies found effects of grammatical gender on people’s perceptions of similarity between objects and people. This was true even though the tasks were performed in English (a language devoid of grammatical gender), even when the tasks were non-linguistic (e.g., rating similarities between unlabeled pictures), and even while subjects were engaged in a verbal interference task. Finally, results showed that cross-linguistic differences in thought can be produced just by grammatical differences and in the absence of other cultural factors.
Application of Firebase in Android App Development-A Study

The web application has become more and more reliant upon large amount of database and unorganized data such as videos, images, audio, text, files and other arbitrary types. It is difficult for Relational Database Management System (RDBMS) to handle the unstructured data. Firebase is a relatively new technology for handling large amount of unstructured data. It is very fast as compared to RDBMS. This paper focuses on the application of Firebase with Android and aims at familiarizing its concepts, related terminologies, advantages and limitations. The paper also tries to demonstrate some of the features of Firebase by developing an Android app.
Optokinetic stimuli: motion sickness, visual acuity, and eye movements.

It is commonly assumed that motion sickness caused by moving visual scenes arises from the illusion of self-motion (i.e., vection).


HYPOTHESES
Both studies reported here investigated whether sickness and vection were correlated. The first study compared sickness and vection created by real and virtual visual displays. The second study investigated whether visual fixation to suppress eye movements affected motion sickness or vection.



In the first experiment subjects viewed an optokinetic drum and a virtual simulation of the optokinetic drum. The second experiment investigated two conditions on a virtual display: a) moving black and white stripes; and b) moving black and white stripes with a stationary cross on which subjects fixated to reduce eye movements.



In the first study, ratings of motion sickness were correlated between the conditions (real and the virtual drum), as were ratings of vection. With both conditions, subjects with poor visual acuity experienced greater sickness. There was no correlation between ratings of vection and ratings of sickness in either condition. In the second study, fixation reduced motion sickness but had no affect on vection. Motion sickness was correlated with visual acuity without fixation, but not with fixation. Again, there was no correlation between vection and motion sickness.



Vection is not the primary cause of sickness with optokinetic stimuli. Vection appears to be influenced by peripheral vision whereas motion sickness is influenced by central vision. When the eyes are free to track moving stimuli, there is an association between visual acuity and motion sickness. Virtual displays can create vection and may be used to investigate visually induced motion sickness.
Treating PTSD in refugees and asylum seekers within the general health care system. A randomized controlled multicenter study.

There has been uncertainty about whether refugees and asylum seekers with PTSD can be treated effectively in standard psychiatric settings in industrialized countries. In this study, Narrative Exposure Therapy (NET) was compared to Treatment As Usual (TAU) in 11 general psychiatric health care units in Norway. The focus was on changes in symptom severity and in the diagnostic status for PTSD and depression.



Refugees and asylum seekers fulfilling the DSM-IV criteria for PTSD (N = 81) were randomized with an a-priori probability of 2:1 to either NET (N = 51) or TAU (N = 30). The patients were assessed with Clinician Administered PTSD Scale, Hamilton rating scale for depression and the MINI Neuropsychiatric Interview before treatment, and again at one and six months after the completion.



Both NET and TAU gave clinically relevant symptom reduction both in PTSD and in depression. NET gave significantly more symptom reduction compared to TAU as well as significantly more reduction in participants with PTSD diagnoses. No difference in treatment efficacy was found between refugees and asylum seekers.



The study indicated that refugees and asylum seekers can be treated successfully for PTSD and depression in the general psychiatric health care system; NET appeared to be a promising treatment for both groups.
Positive affect and markers of inflammation: discrete positive emotions predict lower levels of inflammatory cytokines.

Negative emotions are reliably associated with poorer health (e.g., Kiecolt-Glaser, McGuire, Robles, & Glaser, 2002), but only recently has research begun to acknowledge the important role of positive emotions for our physical health (Fredrickson, 2003). We examine the link between dispositional positive affect and one potential biological pathway between positive emotions and health-proinflammatory cytokines, specifically levels of interleukin-6 (IL-6). We hypothesized that greater trait positive affect would be associated with lower levels of IL-6 in a healthy sample. We found support for this hypothesis across two studies. We also explored the relationship between discrete positive emotions and IL-6 levels, finding that awe, measured in two different ways, was the strongest predictor of lower levels of proinflammatory cytokines. These effects held when controlling for relevant personality and health variables. This work suggests a potential biological pathway between positive emotions and health through proinflammatory cytokines.
The SUNSET framework for simulation, emulation and at-sea testing of underwater wireless sensor networks

The Sapienza University Networking framework for underwater Simulation Emulation and real-life Testing (SUNSET) is a toolkit for the implementation and testing of protocols for underwater sensor networks. SUNSET enables a radical new way of performing experimental research on underwater communications. It allows protocol designers and implementors to easily realize their solutions and to evaluate their performance through simulation, in-lab emulation and trials at sea in a direct and transparent way, and independently of specific underwater hardware platforms. SUNSET provides a complete toolchain of predeployment and deployment time tools able to identify risks, malfunctioning and under-performing solutions before incurring the expense of going to sea. Novel underwater systems can therefore be rapidly and easily investigated. Heterogeneous underwater communication technologies from different vendors can be used, allowing the evaluation of the impact of different combinations of hardware and software on the overall system performance. Using SUNSET, underwater devices can be reconfigured and controlled remotely in real time, using acoustic links. This allows the performance investigation of underwater systems under different settings and configurations and significantly reduces the cost and complexity of at-sea trials. This paper describes the architectural concept of SUNSET and presents some exemplary results of its use in the field. The SUNSET framework has been extensively validated during more than fifteen at-sea experimental campaigns in the past four years. Several of these have been conducted jointly with the NATO STO Centre for Maritime Research and Experimentation (CMRE) under a collaboration between the University of Rome and CMRE.
Chapter 2 Sales Promotion Models

Firms spend a significant part of their marketing budgets on sales promotions. Retail (2012) indicates that during 1997–2011, promotion accounted for roughly 75% of marketing expenditures for US packaged goods manufacturers; the other 25% was for advertising. In 2011, 58% of the budget was spent on promotion to the trade (i.e., from manufacturers to retailers), and 15% on manufacturer promotions to consumers. Since the impact of promotions on sales is usually immediate and strong (Blattberg et al. 1995), promotions are attractive to results-oriented managers seeking to increase sales in the short term (Neslin 2002). In a meta-analysis, Bijmolt et al. (2005) report that the average short-term sales promotion elasticity is –3.63, which implies that a 20% temporary price cut leads to a 73% rise in sales. There are few, if any, other marketing instruments that are equally effective. Because of this, coupled with the availability of scanner data, marketing researchers have been very active in developing models for analyzing sales promotions. Most applications analyze promotions for consumer packaged goods, and this chapter reflects this practice. Nevertheless, many of the models could be applied to other settings as well. This chapter discusses models for measuring sales promotion effects. Part I (Sects. 2.1–2.10) focuses on descriptive models, i.e., models that describe and explain sales promotion phenomena. We start by discussing promotions to consumers. Sections 2.1 through 2.5 focus on analyzing the direct impact of promotions on sales and decomposing that impact into a variety of sources. Section 2.6
Affivir: An affect-based Internet video recommendation system

In this paper, we present Affivir, a video browsing system that recommends Internet videos that match a user’s affective preference. Affivir models a user’s watching behavior as sessions, and dynamically adjusts session parameters to cater to the user’s current mood. In each session, Affivir discovers a user’s affective preference through user interactions, such as watching or skipping videos. Affivir uses video affective features (motion, shot change rate, sound energy, and audio pitch average) to retrieve videos that have similar affective responses. To efficiently search videos of interest from our video repository, all videos in the repository are pre-processed and clustered. Our experimental results shows that Affivir has made a significant improvement in user satisfaction and enjoyment, compared with several other popular baseline approaches.
Integrating Side Information for Boosting Machine Comprehension

Machine Reading and Comprehension recently has drawn a fair amount of attention in the field of natural language processing. In this paper, we consider integrating side information to improve machine comprehension on answering cloze-style questions more precisely. To leverage the external information, we present a novel attention-based architecture which could feed the side information representations into word level embeddings to explore the comprehension performance. Our experiments show consistent improvements of our model over various baselines.
Using a SSVEP-BCI to command a robotic wheelchair

This work presents a Brain-Computer Interface (BCI) based on the Steady-State Visual Evoked Potential (SSVEP) that can discriminate four classes once per second. A statistical test is used to extract the evoked response and a decision tree is used to discriminate the stimulus frequency. Designed according such approach, volunteers were capable to online operate a BCI with hit rates varying from 60% to 100%. Moreover, one of the volunteers could guide a robotic wheelchair through an indoor environment using such BCI. As an additional feature, such BCI incorporates a visual feedback, which is essential for improving the performance of the whole system. All of this aspects allow to use this BCI to command a robotic wheelchair efficiently.
When in Rome ... Learn why the Romans do what they do: how multicultural learning experiences facilitate creativity.

Research suggests that living in and adapting to foreign cultures facilitates creativity. The current research investigated whether one aspect of the adaptation process-multicultural learning-is a critical component of increased creativity. Experiments 1-3 found that recalling a multicultural learning experience: (a) facilitates idea flexibility (e.g., the ability to solve problems in multiple ways), (b) increases awareness of underlying connections and associations, and (c) helps overcome functional fixedness. Importantly, Experiments 2 and 3 specifically demonstrated that functional learning in a multicultural context (i.e., learning about the underlying meaning or function of behaviors in that context) is particularly important for facilitating creativity. Results showed that creativity was enhanced only when participants recalled a functional multicultural learning experience and only when participants had previously lived abroad. Overall, multicultural learning appears to be an important mechanism by which foreign living experiences lead to creative enhancement.
The genetics of colour in fat-tailed sheep: a review

Fat-tailed sheep come in various colours—most are either brown (tan) or black. In some, most of the body is white with the tan or black colour restricted to the front portion of the body or to just around the eyes, muzzle and parts of the legs. The Karakul breed is important for the production of lamb skins of various colours for the fashion industry. As well as the black and tan colours there are Karakuls bred for grey or roan shades, a white colour or one of the numerous Sur shades. In the Sur shades, the base of the birthcoat fibre is one of a number of dark shades and the tip a lighter or white shade. All these colours and many others are the result of the interaction of various genes that determine the specifics of the coat colour of the sheep. A number of sets of nomenclature and symbols have been used to represent the various loci and their alleles that are involved. In the 1980s and 1990s, a standardised set, based closely on those of the mouse and other species was developed. Using this as the framework, the alleles of the Extension, Agouti, Brown, Spotting, Pigmented Head and Roan loci are described using fat-tailed sheep (mainly Damara, Karakul and Persian) as examples. Further discussion includes other types of “white markings,” the Ticking locus and the Sur loci.
Prion amyloid structure explains templating: how proteins can be genes.

The yeast and fungal prions determine heritable and infectious traits, and are thus genes composed of protein. Most prions are inactive forms of a normal protein as it forms a self-propagating filamentous β-sheet-rich polymer structure called amyloid. Remarkably, a single prion protein sequence can form two or more faithfully inherited prion variants, in effect alleles of these genes. What protein structure explains this protein-based inheritance? Using solid-state nuclear magnetic resonance, we showed that the infectious amyloids of the prion domains of Ure2p, Sup35p and Rnq1p have an in-register parallel architecture. This structure explains how the amyloid filament ends can template the structure of a new protein as it joins the filament. The yeast prions [PSI(+)] and [URE3] are not found in wild strains, indicating that they are a disadvantage to the cell. Moreover, the prion domains of Ure2p and Sup35p have functions unrelated to prion formation, indicating that these domains are not present for the purpose of forming prions. Indeed, prion-forming ability is not conserved, even within Saccharomyces cerevisiae, suggesting that the rare formation of prions is a disease. The prion domain sequences generally vary more rapidly in evolution than does the remainder of the molecule, producing a barrier to prion transmission, perhaps selected in evolution by this protection.
Chronic insomnia and its negative consequences for health and functioning of adolescents: a 12-month prospective study.

To estimate prevalence and chronicity of insomnia and the impact of chronic insomnia on health and functioning of adolescents.



Data were collected from 4175 youths 11-17 at baseline and 3134 a year later sampled from managed care groups in a large metropolitan area. Insomnia was assessed by youth-reported DSM-IV symptom criteria. Outcomes are three measures of somatic health, three measures of mental health, two measures of substance use, three measures of interpersonal problems, and three of daily activities.



Over one-fourth reported one or more symptoms of insomnia at baseline and about 5% met diagnostic criteria for insomnia. Almost 46% of those who reported one or more symptoms of insomnia in Wave 1 continued to be cases at Wave 2 and 24% met DSM-IV symptom criteria for chronic insomnia (cases in Wave 1 were also cases in Wave 2). Multivariate analyses found chronic insomnia increased subsequent risk for somatic health problems, interpersonal problems, psychological problems, and daily activities. Significant odds (p < .05) ranged from 1.6 to 5.6 for poor outcomes. These results are the first reported on chronic insomnia among youths, and corroborate, using prospective data, previous findings on correlates of disturbed sleep based on cross-sectional studies.



Insomnia is both common and chronic among adolescents. The data indicate that the burden of insomnia is comparable to that of other psychiatric disorders such as mood, anxiety, disruptive, and substance use disorders. Chronic insomnia severely impacts future health and functioning of youths. Those with chronic insomnia are more likely to seek medical care. These data suggest primary care settings might provide a venue for screening and early intervention for adolescent insomnia.