nils-herrmann/clean_scirepeval huggingface dataset:
Oxidative stress and antioxidant therapy in Parkinson's disease

Parkinson's disease, known also as striatal dopamine deficiency syndrome, is a degenerative disorder of the central nervous system characterized by akinesia, muscular rigidity, tremor at rest, and postural abnormalities. In early stages of parkinsonism, there appears to be a compensatory increase in the number of dopamine receptors to accommodate the initial loss of dopamine neurons. As the disease progresses, the number of dopamine receptors decreases, apparently due to the concomitant degeneration of dopamine target sites on striatal neurons. The loss of dopaminergic neurons in Parkinson's disease results in enhanced metabolism of dopamine, augmenting the formation of H2O2, thus leading to generation of highly neurotoxic hydroxyl radicals (OH.). The generation of free radicals can also be produced by 6-hydroxydopamine or MPTP which destroys striatal dopaminergic neurons causing parkinsonism in experimental animals as well as human beings. Studies of the substantia nigra after death in Parkinson's disease have suggested the presence of oxidative stress and depletion of reduced glutathione; a high level of total iron with reduced level of ferritin; and deficiency of mitochondrial complex I. New approaches designed to attenuate the effects of oxidative stress and to provide neuroprotection of striatal dopaminergic neurons in Parkinson's disease include blocking dopamine transporter by mazindol, blocking NMDA receptors by dizocilpine maleate, enhancing the survival of neurons by giving brain-derived neurotrophic factors, providing antioxidants such as vitamin E, or inhibiting monoamine oxidase B (MAO-B) by selegiline. Among all of these experimental therapeutic refinements, the use of selegiline has been most successful in that it has been shown that selegiline may have a neurotrophic factor-like action rescuing striatal neurons and prolonging the survival of patients with Parkinson's disease.
High resolution magnetic resonance imaging of the patellar retinaculum: normal anatomy, common injury patterns, and pathologies

The medial patellar retinaculum (MPR) and the lateral patellar retinaculum (LPR) are vital structures for the stability of the patella. Failure to identify or treat injury to the patellar retinaculum is associated with recurrent patellar instability and contributes to significant morbidity. High-resolution magnetic resonance imaging (MRI) readily depicts the detailed anatomy of various components (layers) of the retinacula. In this review article, we discuss normal anatomy, important landmarks, common injury patterns, and other pathologies encountered in patellar retinacula. High field strength MRI is an excellent noninvasive tool for evaluation of patellar retinaculum anatomy and pathology. This article will help the reader become familiar with normal imaging findings and the most commonly occurring injuries/pathologies in MPR and LPR.
An Evaluation of Local Shape-Based Features for Pedestrian Detection

Pedestrian detection in real world scenes is a challenging problem. In recent years a variety of approaches have been proposed, and impressive results have been reported on a variety of databases. This paper systematically evaluates (1) various local shape descriptors, namely Shape Context and Local Chamfer descriptor and (2) four different interest point detectors for the detection of pedestrians. Those results are compared to the standard global Chamfer matching approach. A main result of the paper is that Shape Context trained on real edge images rather than on clean pedestrian silhouettes combined with the Hessian-Laplace detector outperforms all other tested approaches.
Research on Lightweight MVC Framework Based on Spring MVC and Mybatis

For the development and operating efficiency of Web applications based on the Model-View-Controller (MVC) framework, and, according to the actual business environment and needs in the project practice, the framework of Web application system is studied in this paper. Through the research of Spring MVC framework and Mybatis framework as well as some related core techniques, combined with JSP and JSTL technology, this paper realizes the design of a lightweight Web application framework based on Spring MVC and Mybatis.
Big data security analysis approach using Computational Intelligence techniques in R for desktop users

Big Data security analysis is commonly used for the analysis of large volume security data from an organisational perspective, requiring powerful IT infrastructure and expensive data analysis tools. Therefore, it can be considered to be inaccessible to the vast majority of desktop users and is difficult to apply to their rapidly growing data sets for security analysis. A number of commercial companies offer a desktop-oriented big data security analysis solution; however, most of them are prohibitive to ordinary desktop users with respect to cost and IT processing power. This paper presents an intuitive and inexpensive big data security analysis approach using Computational Intelligence (CI) techniques for Windows desktop users, where the combination of Windows batch programming, EmEditor and R are used for the security analysis. The simulation is performed on a real dataset with more than 10 million observations, which are collected from Windows Firewall logs to demonstrate how a desktop user can gain insight into their abundant and untouched data and extract useful information to prevent their system from current and future security threats. This CI-based big data security analysis approach can also be extended to other types of security logs such as event logs, application logs and web logs.
The First Workshop on Knowledge Graphs and Semantics for Text Retrieval and Analysis (KG4IR)

Knowledge graphs have been used throughout the history of information retrieval for a variety of tasks. Technological advances in knowledge acquisition and alignment technology from the last few years gave rise to a body of new approaches for utilizing knowledge graphs in text retrieval tasks. It is therefore time to consolidate the community efforts in studying how knowledge graph technology can be employed in information retrieval systems in the most effective way. It is also time to start a dialogue with researchers working on knowledge acquisition and alignment to ensure that resulting technologies and algorithms meet the demands posed by information retrieval tasks. The goal of this workshop is to bring together a community of researchers and practitioners who are interested in using, aligning, and constructing knowledge graphs and similar semantic resources for information retrieval applications.
Design of edge termination on non-uniform 100-V super-junction trench power MOSFET

A design methodology for the edge termination is proposed to achieve the same breakdown voltage of the non-uniform super-junction (SJ) trench metal-oxide semiconductor field-effect transistor (TMOSFET) cell structure. A simple analytical solution for the effect of charge imbalance on the termination region is suggested, and it is satisfied with the simulation of potential distribution. The doping concentration decreases linearly in the vertical direction from the N drift region at the bottom to the channel at the top. The structure modeling and the characteristic analyses for potential distribution and electric field are simulated by using of the SILVACO TCAD 2D device simulator,  As a result, the breakdown voltage of 132V is successfully achieved at the edge termination of non-uniform SJ TMOSFET, which has the better performance than the conventional structure in the breakdown voltage.
Efficient self-shadowed radiosity normal mapping

In Valve's Source graphics engine, bump mapping is combined with precomputed radiosity lighting to provide realistic surface illumination. When bump map data is derived from geometric descriptions of surface detail (such as height maps), only the lighting effects caused by the surface orientation are preserved. The significant lighting cues due to lighting occlusion by surface details are lost. While it is common to use another texture channel to hold an "ambient occlusion" field, this only provides a darkening effect which is independent of the direction from which the surface is being lit and requires an auxiliary channel of data.
 In this chapter, we present a modification to the Radiosity Normal Mapping system that we have described in this course in the past. This modification provides a directional occlusion function to the bump maps, which requires no additional texture memory and is faster than our previous non-shadowing solution.
B LACK BOX VARIATIONAL INFERENCE FOR STATE SPACE MODELS

Latent variable time-series models are among the most heavily used tools from machine learning and applied statistics. These models have the advantage of learning latent structure both from noisy observations and from the temporal ordering in the data, where it is assumed that meaningful correlation structure exists across time. A few highly-structured models, such as the linear dynamical system with linear-Gaussian observations, have closed-form inference procedures (e.g. the Kalman Filter), but this case is an exception to the general rule that exact posterior inference in more complex generative models is intractable. Consequently, much work in time-series modeling focuses on approximate inference procedures for one particular class of models. Here, we extend recent developments in stochastic variational inference to develop a ‘black-box’ approximate inference technique for latent variable models with latent dynamical structure. We propose a structured Gaussian variational approximate posterior that carries the same intuition as the standard Kalman filter-smoother but, importantly, permits us to use the same inference approach to approximate the posterior of much more general, nonlinear latent variable generative models. We show that our approach recovers accurate estimates in the case of basic models with closed-form posteriors, and more interestingly performs well in comparison to variational approaches that were designed in a bespoke fashion for specific non-conjugate models.
Security of CCTV and Video Surveillance Systems: Threats, Vulnerabilities, Attacks, and Mitigations

Video surveillance, closed-circuit TV and IP-camera systems became virtually omnipresent and indispensable for many organizations, businesses, and users. Their main purpose is to provide physical security, increase safety, and prevent crime. They also became increasingly complex, comprising many communication means, embedded hardware and non-trivial firmware. However, most research to date focused mainly on the privacy aspects of such systems, and did not fully address their issues related to cyber-security in general, and visual layer (i.e., imagery semantics) attacks in particular. In this paper, we conduct a systematic review of existing and novel threats in video surveillance, closed-circuit TV and IP-camera systems based on publicly available data. The insights can then be used to better understand and identify the security and the privacy risks associated with the development, deployment and use of these systems. We study existing and novel threats, along with their existing or possible countermeasures, and summarize this knowledge into a comprehensive table that can be used in a practical way as a security checklist when assessing cyber-security level of existing or new CCTV designs and deployments. We also provide a set of recommendations and mitigations that can help improve the security and privacy levels provided by the hardware, the firmware, the network communications and the operation of video surveillance systems. We hope the findings in this paper will provide a valuable knowledge of the threat landscape that such systems are exposed to, as well as promote further research and widen the scope of this field beyond its current boundaries.
Using wireless technologies in healthcare

With an increasingly mobile society and the worldwide deployment of mobile and wireless networks, wireless infrastructure can support many current and emerging healthcare applications. However, before wireless infrastructure can be used in a wide scale, there are several challenges that must be overcome. These include how to best utilise the capabilities of diverse wireless technologies and how to effectively manage the complexity of wireless and mobile networks in healthcare applications. In this paper, we discuss how wireless technologies can be applied in the healthcare environment. Additionally, some open issues and challenges are also discussed.
Power in Simplicity with ASM: Tracing the Aggressive Space Mapping Algorithm Over Two Decades of Development and Engineering Applications

The most widely used space mapping approach to efficient design optimization is the aggressive space mapping (ASM) algorithm. My purpose here is to present both a historical account and a technical reassessment of ASM, starting with the invention of the space mapping concept and continuing with a brief overview of the most fundamental space mapping optimization methods developed until now, within which ASM is framed. The article goes on to review over two decades of ASM evolution, in terms not only of the theoretical contributions directly incorporated into the ASM algorithm but also of the most significant engineering applications documented for ASM to date.
A New Gaze-BCI-Driven Control of an Upper Limb Exoskeleton for Rehabilitation in Real-World Tasks

This paper proposes a new multimodal architecture for gaze-independent brain-computer interface (BCI)-driven control of a robotic upper limb exoskeleton for stroke rehabilitation to provide active assistance in the execution of reaching tasks in a real setting scenario. At the level of action plan, the patient's intention is decoded by means of an active vision system, through the combination of a Kinect-based vision system, which can online robustly identify and track 3-D objects, and an eye-tracking system for objects selection. At the level of action generation, a BCI is used to control the patient's intention to move his/her own arm, on the basis of brain activity analyzed during motor imagery. The main kinematic parameters of the reaching movement (i.e., speed, acceleration, and jerk) assisted by the robot are modulated by the output of the BCI classifier so that the robot-assisted movement is performed under a continuous control of patient's brain activity. The system was experimentally evaluated in a group of three healthy volunteers and four chronic stroke patients. Experimental results show that all subjects were able to operate the exoskeleton movement by BCI with a classification error rate of 89.4±5.0% in the robot-assisted condition, with no difference of the performance observed in stroke patients compared with healthy subjects. This indicates the high potential of the proposed gaze-BCI-driven robotic assistance for neurorehabilitation of patients with motor impairments after stroke since the earliest phase of recovery.
The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species

The correlation of phenotypic outcomes with genetic variation and environmental factors is a core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient phenotypes may not match known diseases, candidate variants may be in genes that have not been characterized, model organisms may not recapitulate human or veterinary diseases, filling evolutionary gaps is difficult, and many resources must be queried to find potentially significant genotype-phenotype associations. Non-human organisms have proven instrumental in revealing biological mechanisms. Advanced informatics tools can identify phenotypically relevant disease models in research and diagnostic contexts. Large-scale integration of model organism and clinical research data can provide a breadth of knowledge not available from individual sources and can provide contextualization of data back to these sources. The Monarch Initiative (monarchinitiative.org) is a collaborative, open science effort that aims to semantically integrate genotype-phenotype data from many species and sources in order to support precision medicine, disease modeling, and mechanistic exploration. Our integrated knowledge graph, analytic tools, and web services enable diverse users to explore relationships between phenotypes and genotypes across species.
Model-driven Testing of RESTful APIs

In contrast to the increasing popularity of REpresentational State Transfer (REST), systematic testing of RESTful Application Programming Interfaces (API) has not attracted much attention so far. This paper describes different aspects of automated testing of RESTful APIs. Later, we focus on functional and security tests, for which we apply a technique called model-based software development. Based on an abstract model of the RESTful API that comprises resources, states and transitions a software generator not only creates the source code of the RESTful API but also creates a large number of test cases that can be immediately used to test the implementation. This paper describes the process of developing a software generator for test cases using state-of-the-art tools and provides an example to show the feasibility of our approach.
Aggression Detection in Social Media using Deep Neural Networks

With the rise of user-generated content in social media coupled with almost non-existent moderation in many such systems, aggressive contents have been observed to rise in such forums. In this paper, we work on the problem of aggression detection in social media. Aggression can sometimes be expressed directly or overtly or it can be hidden or covert in the text. On the other hand, most of the content in social media is non-aggressive in nature. We propose an ensemble based system to classify an input post into one of three classes, namely, Overtly Aggressive, Covertly Aggressive, and Non-aggressive. Our approach uses three deep learning methods, namely, Convolutional Neural Networks (CNN) with five layers (input, convolution, pooling, hidden, and output), Long Short Term Memory networks (LSTM), and Bi-directional Long Short Term Memory networks (Bi-LSTM). A majority voting based ensemble method is used to combine these classifiers (CNN, LSTM, and Bi-LSTM). We trained our method on Facebook comments dataset and tested on Facebook comments (in-domain) and other social media posts (cross-domain). Our system achieves the F1-score (weighted) of 0.604 for Facebook posts and 0.508 for social media posts.
Design of broadband orthomode transducer based on double ridged waveguide

A Ku broadband OMT for satellite communication applications is designed. This OMT consists of a stepped double ridged waveguide junction, a power combiner and an axial branch. It is similar to that of B⊘ifot junction, but has no septum and pins which increase the complexity of the structure. The OMT with a size of 42×44×100mm3 can cover from 10.44GHz to 14.93GHz (35.4% bandwidth). The return losses are better than 27dB and the isolation is greater than 70dB. The OMT has excellent performance and can be easily manufactured. In this design, the mode matching technique is used to optimize the components of the OMT.
Software Testing Techniques: A Literature Review

With the growing complexity of today's software applications injunction with the increasing competitive pressure has pushed the quality assurance of developed software towards new heights. Software testing is an inevitable part of the Software Development Lifecycle, and keeping in line with its criticality in the pre and post development process makes it something that should be catered with enhanced and efficient methodologies and techniques. This paper aims to discuss the existing as well as improved testing techniques for the better quality assurance purposes.
SAM-RCNN: Scale-Aware Multi-Resolution Multi-Channel Pedestrian Detection

Convolutional neural networks (CNN) have enabled significant improvements in pedestrian detection owing to the strong representation ability of the CNN features. Recently, aggregating features from multiple layers of a CNN has been considered as an effective approach, however, the same approach regarding feature representation is used for detecting pedestrians of varying scales. Consequently, it is not guaranteed that the feature representation for pedestrians of a particular scale is optimised. In this paper, we propose a Scale-Aware Multi-resolution (SAM) method for pedestrian detection which can adaptively select multi-resolution convolutional features according to pedestrian sizes. The proposed SAM method extracts the appropriate CNN features that have strong representation ability as well as sufficient feature resolution, given the size of the pedestrian candidate output from a region proposal network. Moreover, we propose an enhanced SAM method, termed as SAM+, which incorporates complementary features channels and achieves further performance improvement. Evaluations on the challenging Caltech and KITTI pedestrian benchmarks demonstrate the superiority of our proposed method.
A multiresolution symbolic representation of time series

Efficiently and accurately searching for similarities among time series and discovering interesting patterns is an important and non-trivial problem. In this paper, we introduce a new representation of time series, the multiresolution vector quantized (MVQ) approximation, along with a new distance function. The novelty of MVQ is that it keeps both local and global information about the original time series in a hierarchical mechanism, processing the original time series at multiple resolutions. Moreover, the proposed representation is symbolic employing key subsequences and potentially allows the application of text-based retrieval techniques into the similarity analysis of time series. The proposed method is fast and scales linearly with the size of database and the dimensionality. Contrary to the vast majority in the literature that uses the Euclidean distance, MVQ uses a multi-resolution/hierarchical distance function. We performed experiments with real and synthetic data. The proposed distance function consistently outperforms all the major competitors (Euclidean, dynamic time warping, piecewise aggregate approximation) achieving up to 20% better precision/recall and clustering accuracy on the tested datasets.
Short-Term Compassion Training Increases Prosocial Behavior in a Newly Developed Prosocial Game

Compassion has been suggested to be a strong motivator for prosocial behavior. While research has demonstrated that compassion training has positive effects on mood and health, we do not know whether it also leads to increases in prosocial behavior. We addressed this question in two experiments. In Experiment 1, we introduce a new prosocial game, the Zurich Prosocial Game (ZPG), which allows for repeated, ecologically valid assessment of prosocial behavior and is sensitive to the influence of reciprocity, helping cost, and distress cues on helping behavior. Experiment 2 shows that helping behavior in the ZPG increased in participants who had received short-term compassion training, but not in participants who had received short-term memory training. Interindividual differences in practice duration were specifically related to changes in the amount of helping under no-reciprocity conditions. Our results provide first evidence for the positive impact of short-term compassion training on prosocial behavior towards strangers in a training-unrelated task.