nils-herrmann/clean_scirepeval huggingface dataset:
The impact of macromastia on adolescents: a cross-sectional study.

To determine the physical and psychosocial impact of macromastia on adolescents considering reduction mammaplasty in comparison with healthy adolescents.



The following surveys were administered to adolescents with macromastia and control subjects, aged 12 to 21 years: Short-Form 36v2, Rosenberg Self-Esteem Scale, Breast-Related Symptoms Questionnaire, and Eating-Attitudes Test-26 (EAT-26). Demographic variables and self-reported breast symptoms were compared between the 2 groups. Linear regression models, unadjusted and adjusted for BMI category (normal weight, overweight, obese), were fit to determine the effect of case status on survey score. Odds ratios for the risk of disordered eating behaviors (EAT-26 score ≥ 20) in cases versus controls were also determined.



Ninety-six subjects with macromastia and 103 control subjects participated in this study. Age was similar between groups, but subjects with macromastia had a higher BMI (P = .02). Adolescents with macromastia had lower Short-Form 36v2 domain, Rosenberg Self-Esteem Scale, and Breast-Related Symptoms Questionnaire scores and higher EAT-26 scores compared with controls. Macromastia was also associated with a higher risk of disordered eating behaviors. In almost all cases, the impact of macromastia was independent of BMI category.



Macromastia has a substantial negative impact on health-related quality of life, self-esteem, physical symptoms, and eating behaviors in adolescents with this condition. These observations were largely independent of BMI category. Health care providers should be aware of these important negative health outcomes that are associated with macromastia and consider early evaluation for adolescents with this condition.
Design and validation of a torque dense, highly backdrivable powered knee-ankle orthosis

This paper presents the mechatronic design and experimental validation of a novel powered knee-ankle orthosis for testing torque-driven rehabilitation control strategies. The modular actuator of the orthosis is designed with a torque dense motor and a custom low-ratio transmission (24:1) to provide mechanical transparency to the user, allowing them to actively contribute to their joint kinematics during gait training. The 4.88 kg orthosis utilizes frameless components and light materials, such as aluminum alloy and carbon fiber, to reduce its mass. A human subject experiment demonstrates accurate torque control with high output torque during stance and low backdrive torque during swing at fast walking speeds. This work shows that backdrivability, precise torque control, high torque output, and light weight can be achieved in a powered orthosis without the high cost and complexity of variable transmissions, clutches, and/or series elastic components.
Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats.

We investigated the effect of low-fat (2.5%) dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei on progression of high fructose-induced type 2 diabetes in rats.



Diabetes was induced in male albino Wistar rats by feeding 21% fructose in water. The body weight, food and water intakes, fasting blood glucose, glycosylated hemoglobin, oral glucose tolerance test, plasma insulin, liver glycogen content, and blood lipid profile were recorded. The oxidative status in terms of thiobarbituric acid-reactive substances and reduced glutathione contents in liver and pancreatic tissues were also measured.



Values for blood glucose, glycosylated hemoglobin, glucose intolerance, plasma insulin, liver glycogen, plasma total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and blood free fatty acids were increased significantly after 8 wk of high fructose feeding; however, the dahi-supplemented diet restricted the elevation of these parameters in comparison with the high fructose-fed control group. In contrast, high-density lipoprotein cholesterol decreased slightly and was retained in the dahi-fed group. The dahi-fed group also exhibited lower values of thiobarbituric acid-reactive substances and higher values of reduced glutathione in liver and pancreatic tissues compared with the high fructose-fed control group.



The probiotic dahi-supplemented diet significantly delayed the onset of glucose intolerance, hyperglycemia, hyperinsulinemia, dyslipidemia, and oxidative stress in high fructose-induced diabetic rats, indicating a lower risk of diabetes and its complications.
State-of-the-art in artificial neural network applications: A survey

This is a survey of neural network applications in the real-world scenario. It provides a taxonomy of artificial neural networks (ANNs) and furnish the reader with knowledge of current and emerging trends in ANN applications research and area of focus for researchers. Additionally, the study presents ANN application challenges, contributions, compare performances and critiques methods. The study covers many applications of ANN techniques in various disciplines which include computing, science, engineering, medicine, environmental, agriculture, mining, technology, climate, business, arts, and nanotechnology, etc. The study assesses ANN contributions, compare performances and critiques methods. The study found that neural-network models such as feedforward and feedback propagation artificial neural networks are performing better in its application to human problems. Therefore, we proposed feedforward and feedback propagation ANN models for research focus based on data analysis factors like accuracy, processing speed, latency, fault tolerance, volume, scalability, convergence, and performance. Moreover, we recommend that instead of applying a single method, future research can focus on combining ANN models into one network-wide application.
Sustained satiety induced by food foams is independent of energy content, in healthy adults

Our previous research demonstrated high, sustained satiety effects of stabilized food foams relative to their non-aerated compositions. Here we test if the energy and macronutrients in a stabilized food foam are critical for its previously demonstrated satiating effects. In a randomized, crossover design, 72 healthy subjects consumed 400 mL of each of four foams, one per week over four weeks, 150 min after a standardized breakfast. Appetite ratings were collected for 180 min post-foam. The reference was a normal energy food foam (NEF1, 280 kJ/400 mL) similar to that used in our previous research. This was compared to a very low energy food foam (VLEF, 36 kJ/400 mL) and 2 alternative normal energy foams (NEF2 and NEF3) testing possible effects of compositional differences other than energy (i.e. emulsifier and carbohydrate source). Appetite ratings were quantified as area under the curve (AUC) and time to return to baseline (TTRTB). Equivalence to NEF1 was predefined as the 90% confidence interval of between-treatment differences in AUC being within -5 to +5 mm/min. All treatments similarly affected appetite ratings, with mean AUC for fullness ranging between 49.1 and 52.4 mm/min. VLEF met the statistical criterion for equivalence to NEF1 for all appetite AUC ratings, but NEF2 and NEF3 did not. For all foams the TTRTB for satiety and fullness were consistently between 150 and 180 min, though values were shortest for NEF2 and especially NEF3 foams for most appetite scales. In conclusion, the high, sustained satiating effects of these food foams are independent of energy and macronutrient content at the volumes tested.
Quadrature broadband phase shift generation using passive RC polyphase filter for RF front-end

This paper reviews the state of the art of a polyphase complex filter for RF front-end low-IF transceivers applications. We then propose a multi-stage polyphase filter design to generate a quadrature I/Q signal to achieve a wideband precision quadrature phase shift with a constant 90 ° phase difference for self-interference cancellation circuit for full duplex radio. The number of the stages determines the bandwidth requirement of the channel. An increase of 87% in bandwidth is attained when our design is implemented in multi-stage from 2 to an extended 6 stages. A 4-stage polyphase filter achieves 2.3 GHz bandwidth.
X-ray crystallographic structure of the Norwalk virus capsid.

Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
A data set for evaluating the performance of multi-class multi-object video tracking

One of the challenges in evaluating multi-object video detection, tracking and classification systems is having publically available data sets with which to compare different systems. However, the measures of performance for tracking and classification are different. Data sets that are suitable for evaluating tracking systems may not be appropriate for classification. Tracking video data sets typically only have ground truth track IDs, while classification video data sets only have ground truth class-label IDs. The former identifies the same object over multiple frames, while the latter identifies the type of object in individual frames. This paper describes an advancement of the ground truth meta-data for the DARPA Neovision2 Tower data set to allow both the evaluation of tracking and classification. The ground truth data sets presented in this paper contain unique object IDs across 5 different classes of object (Car, Bus, Truck, Person, Cyclist) for 24 videos of 871 image frames each. In addition to the object IDs and class labels, the ground truth data also contains the original bounding box coordinates together with new bounding boxes in instances where un-annotated objects were present. The unique IDs are maintained during occlusions between multiple objects or when objects re-enter the field of view. This will provide: a solid foundation for evaluating the performance of multi-object tracking of different types of objects, a straightforward comparison of tracking system performance using the standard Multi Object Tracking (MOT) framework, and classification performance using the Neovision2 metrics. These data have been hosted publically.
Change Detection Based on Gabor Wavelet Features for Very High Resolution Remote Sensing Images

In this letter, we propose a change detection method based on Gabor wavelet features for very high resolution (VHR) remote sensing images. First, Gabor wavelet features are extracted from two temporal VHR images to obtain spatial and contextual information. Then, the Gabor-wavelet-based difference measure (GWDM) is designed to generate the difference image. In GWDM, a new local similarity measure is defined, in which the Markov random field neighborhood system is incorporated to obtain a local relationship, and the coefficient of variation method is applied to discriminate contributions from different features. Finally, the fuzzy c-means cluster algorithm is employed to obtain the final change map. Experiments employing QuickBird and SPOT5 images demonstrate the effectiveness of the proposed approach.
Qualitative exploration of a client-centered, goal-directed approach to community-based occupational therapy for adults with traumatic brain injury.

We explored the clinical application of goal-directed therapy in community-based rehabilitation from the perspective of clients with traumatic brain injury (TBI), their significant others, and their treating occupational therapists.



Twelve people with TBI and their significant others completed an outpatient, goal-directed, 12-week occupational therapy program. Semistructured interviews with 12 participants, 10 significant others, and 3 occupational therapists involved in delivering the therapy programs explored their experiences of goal-directed therapy.



Participants, their significant others, and therapists described goal-directed therapy positively, expressing satisfaction with progress made.



Goals provide structure, which facilitates participation in rehabilitation despite the presence of barriers, including reduced motivation and impaired self-awareness. A therapist-facilitated, structured, goal-setting process in which the client, therapist, and significant others work in partnership can enhance the process of goal setting and goal-directed rehabilitation in a community rehabilitation context.
JPE 10-6-13 DSP Based Series-Parallel Connected Two Full-Bridge DC-DC Converter with Interleaving Output Current Sharing

Input-series-output-parallel (ISOP) connected DC-DC converters enable low voltage rating switches to be used in high voltage input applications. In this paper, a DSP is adopted to generate digital phase-shifted PWM signals and to fulfill the closed-loop control function for ISOP connected two full-bridge DC-DC converters. Moreover, a stable output current sharing control strategy is proposed for the system, with which equal sharing of the input voltage and the load current can be achieved without any input voltage control loops. Based on small signal analysis with the state space average method, a loop gain design with the proposed scheme is made. Compared with the conventional IVS scheme, the proposed strategy leads to simplification of the output voltage regulator design and better static and dynamic responses. The effectiveness of the proposed control strategy is verified by the simulation and experimental results of an ISOP system made up of two full-bridge DC-DC converters.
Transition Contour Synthesis with Dynamic Patch Transitions

In this article, we present a novel approach for modulating the shape of transitions between terrain materials to produce detailed and varied contours where blend resolution is limited. Whereas texture splatting and blend mapping add detail to transitions at the texel level, our approach addresses the broader shape of the transition by introducing intermittency and irregularity. Our results have proven that enriched detail of the blend contour can be achieved with a performance competitive to existing approaches without additional texture, geometry resources, or asset preprocessing. We achieve this by compositing blend masks on-the-fly with the subdivision of texture space into differently sized patches to produce irregular contours from minimal artistic input. Our approach is of particular importance for applications where GPU resources or artistic input is limited or impractical.
Parallel scrambler for high-speed applications

In order to improve the speed limitation of serial scrambler, we propose a new parallel scrambler architecture and circuit to overcome the limitation of serial scrambler. A very systematic parallel scrambler design methodology is first proposed. The critical path delay is only one D-register and one xor gate of two inputs. Thus, it is superior to other proposed circuits in high-speed applications. A new DET D-register with embedded xor operation is used as a basic circuit block of the parallel scrambler. Measurement results show the proposed parallel scrambler can operate in 40 Gbps with 16 outputs in TSMC 0.18-/spl mu/m CMOS process.
The psychology of compensatory and retributive justice.

How do observers respond when the actions of one individual inflict harm on another? The primary reaction to carelessly inflicted harm is to seek restitution; the offender is judged to owe compensation to the harmed individual. The primary reaction to harm inflicted intentionally is moral outrage producing a desire for retribution; the harm-doer must be punished. Reckless conduct, an intermediate case, provokes reactions that involve elements of both careless and intentional harm. The moral outrage felt by those who witness transgressions is a product of both cognitive interpretations of the event and emotional reactions to it. Theory about the exact nature of the emotional reactions is considered, along with suggestions for directions for future research.
Thread lifting: a minimally invasive surgical technique for long-standing facial paralysis

Chronic facial paralysis induces degenerative facial muscle changes on the involved side, thus, making the individual seem as older than their actual age. Furthermore, contralateral facial hypertrophy aggravates facial asymmetry. A thread-lifting procedure has been used widely for correction of a drooping or wrinkled face due to the aging process. In addition, botulinum toxin injection can be used to reduce facial hypertrophy. The aim of study was to evaluate the effectiveness of thread lifting with botulinum toxin injection for chronic facial paralysis. A total 34 of patients with chronic facial paralysis were enrolled from March to October 2014. Thread lifting for elevating loose facial muscles on the ipsilateral side and botulinum toxin A for controlling the facial muscle hypertrophy on the contralateral side were conducted. Facial function was evaluated using the Sunnybrook grading system and dynamic facial asymmetry ratios 1 year after treatment. All 34 patients displayed improved facial symmetry and showed improvement in Sunnybrook scores (37.4 vs. 83.3) and dynamic facial asymmetry ratios (0.58 vs 0.92). Of the 34 patients, 28 (82.4%) reported being satisfied with treatment. The application of subdermal suspension with a reabsorbable thread in conjunction with botulinum toxin A to optimize facial rejuvenation of the contralateral side constitutes an effective and safe procedure for face lifting and rejuvenation of a drooping face as a result of long-lasting facial paralysis. Die chronische Fazialisparese induziert degenerative Veränderungen der Gesichtsmuskulatur auf der betroffenen Seite. In der Folge wirkt der Patient älter, als er tatsächlich ist.  Weiteren verstärkt eine kontralaterale Hypertrophie die Gesichtsasymmetrie. Ein Fadenliftingverfahren findet breite Anwendung zur Korrektur eines durch den Alterungsprozess hängenden oder faltigen Gesichts. Zusätzlich kann Botulinumtoxin injiziert werden, um die Gesichtshypertrophie zu verringern. In der vorliegenden Studie sollte die Wirksamkeit eines Fadenliftings mit Botulinumtoxininjektionen bei chronischer Fazialisparese beurteilt werden.
Interactive Paths Embedding for Semantic Proximity Search on Heterogeneous Graphs

Semantic proximity search on heterogeneous graph is an important task, and is useful for many applications. It aims to measure the proximity between two nodes on a heterogeneous graph w.r.t. some given semantic relation. Prior work often tries to measure the semantic proximity by paths connecting a query object and a target object. Despite the success of such path-based approaches, they often modeled the paths in a weakly coupled manner, which overlooked the rich interactions among paths. In this paper, we introduce a novel concept of interactive paths to model the inter-dependency among multiple paths between a query object and a target object. We then propose an Interactive Paths Embedding (IPE) model, which learns low-dimensional representations for the resulting interactive-paths structures for proximity estimation. We conduct experiments on seven relations with four different types of heterogeneous graphs, and show that our model outperforms the state-of-the-art baselines.
Classroom salon: a tool for social collaboration

Classroom Salon is an on-line social collaboration tool that allows instructors to create, manage, and analyze social net- works (called Salons) to enhance student learning. Students in a Salon can cooperatively create, comment on, and modify documents. Classroom Salon provides tools that allow the instructor to monitor the social networks and gauge both student participation and individual effectiveness. This pa- per describes Classroom Salon, provides some use cases that we have developed for introductory computer science classes and presents some preliminary observations of using this tool in several computer science courses at Carnegie Mellon University.
Efficient planar fiber-to-chip coupler based on two-stage adiabatic evolution.

A new, efficient adiabatic in-plane fiber-to-chip coupler design is proposed. In this design, the light from the fiber is coupled into a low-index waveguide with matching mode size. The mode is first adiabatically reduced in size with a rib taper, and then transferred into a high-index (e.g. silicon) waveguide with an inverse taper. The two-stage design allows to reduce the coupler length multiple times in comparison with pure inverse taper-based couplers of similar efficiency. The magnitude of length reduction increases with the refractive index of the low-index waveguide and the fiber mode size.
The biology behind mTOR inhibition in sarcoma.

Dysregulation of the mammalian target of rapamycin (mTOR) pathway has been found in many human tumors and implicated in the promotion of cancer cell growth and survival. Hence, the mTOR pathway is considered an important target for anticancer drug development. Currently, the mTOR inhibitor rapamycin and its derivatives CCI-779, RAD001, and AP23573 are being evaluated in cancer clinical trials. To date, clinical results have shown good tolerability of treatment with mTOR inhibitors in most reports and varying effectiveness of mTOR inhibitors in a variety of tumors in a subset of patients. For the targeted treatment of sarcomas, AP23573 has shown promising clinical efficacy and low toxicity profiles in patients. Further studies should define the optimal dose/schedule, patient selection, and combination strategies with other biological agents, especially those targeting signaling pathways crucial for cell survival. Disclosure of potential conflicts of interest is found at the end of this article.
Heat Shock Proteins and Cancer.

Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis. HSPs may also have potential clinical uses as biomarkers for cancer diagnosis, for assessing disease progression, or as therapeutic targets for cancer therapy.