nils-herrmann/clean_scirepeval huggingface dataset:
Study of the antibacterial and antifungal activities of synthetic benzyl bromides, ketones, and corresponding chalcone derivatives

Several applications of chalcones and their derivatives encouraged researchers to increase their synthesis as an alternative for the treatment of pathogenic bacterial and fungal infections. In the present study, chalcone derivatives were synthesized through cross aldol condensation reaction between 4-(N,N-dimethylamino)benzaldehyde and multiarm aromatic ketones. The multiarm aromatic ketones were synthesized through nucleophilic substitution reaction between 4-hydroxy acetophenone and benzyl bromides. The benzyl bromides, multiarm aromatic ketones, and corresponding chalcone derivatives were evaluated for their activities against eleven clinical pathogenic Gram-positive, Gram-negative bacteria, and three pathogenic fungi by the disk diffusion method. The minimum inhibitory concentration was determined by the microbroth dilution technique. The results of the present study demonstrated that benzyl bromide derivatives have strong antibacterial and antifungal properties as compared to synthetic chalcone derivatives and ketones. Benzyl bromides (1a and 1c) showed high ester activity against Gram-positive bacteria and fungi but moderate activity against Gram-negative bacteria. Therefore, these compounds may be considered as good antibacterial and antifungal drug discovery. However, substituted ketones (2a-b) as well as chalcone derivatives (3a-c) showed no activity against all the tested strains except for ketone (2c), which showed moderate activity against Candida albicans.
Multi-bit Data Hiding in Randomly Chosen LSB Layers of an Audio

LSB techniques generally embed data in the same LSB position of consecutive samples which helps intruders to extract secret information easily. This paper solve this problem by introducing a robust audio steganography technique where data is embedded in multiple layers of LSB chosen randomly and in non-consecutive samples. The choice of random LSB layers and non-consecutive pixels for embedding increases robustness as well as the strength of proposed steganography algorithm. It is seriously a problem that the data hiding at non-contiguous sample locations loses the capacity of stego audio. This problem is solved here by embedding three bits within a target samples. The capacity is also increased by using 6 bits ASCII representation of secret message instead of 7. The proposed technique is tested by embedding text of different payloads within the cover audio and also compared with existing techniques based on quality and capacity.
Quantitatively measuring a large-scale agile transformation

Agile software development continues to grow in popularity and is being adopted by more and more organizations. However, there is a need for empirical evidence on the impact, benefits and drawbacks of an agile transformation in an organization since the cost for such a transformation in terms of money, disrupted working routines and quality of development can become considerable. Currently, such evidence exists in the form of success stores and case studies, mostly of qualitative nature.  Provide a metrics model to quantitatively measure the impact of an agile transformation in a software development organization.  The metrics model was elicited with the use of the Goal Question Metric approach.  A quantitative metrics model containing eight rigorously described metrics is presented and followed by its application to evaluate an agile and lean transformation in a large international telecommunication organization with 350 employees in two sites.  The metrics model was sensitive to the changes that occurred in the organization and revealed significant improvements in six of the eight metrics and a deterioration in one of the metrics.
The Role of Isotretinoin Therapy for Cushing's Disease: Results of a Prospective Study.

This prospective open trial aimed to evaluate the efficacy and safety of isotretinoin (13-cis-retinoic acid) in patients with Cushing's disease (CD).  Sixteen patients with CD and persistent or recurrent hypercortisolism after transsphenoidal surgery were given isotretinoin orally for 6-12 months. The drug was started on 20 mg daily and the dosage was increased up to 80 mg daily if needed and tolerated. Clinical, biochemical, and hormonal parameters were evaluated at baseline and monthly for 6-12 months.  Of the 16 subjects, 4% (25%) persisted with normal urinary free cortisol (UFC) levels at the end of the study. UFC reductions of up to 52.1% were found in the rest. Only patients with UFC levels below 2.5-fold of the upper limit of normal achieved sustained UFC normalization. Improvements of clinical and biochemical parameters were also noted mostly in responsive patients. Typical isotretinoin side-effects were experienced by 7 patients (43.7%), though they were mild and mostly transient. We also observed that the combination of isotretinoin with cabergoline, in relatively low doses, may occasionally be more effective than either drug alone.  Isotretinoin may be an effective and safe therapy for some CD patients, particularly those with mild hypercortisolism.
Inflammatory bowel disease biopsies: updated British Society of Gastroenterology reporting guidelines.

Accurate histopathological assessment of biopsies is important for the diagnosis, subclassification, and management of chronic idiopathic inflammatory bowel disease (IBD). British Society of Gastroenterology (BSG) guidelines for the initial histopathological diagnosis of IBD were published in 1997. Changes since then include: more widespread use of full colonoscopy; greater recognition of the effects of time and treatment; improved documentation of variations in anatomical distribution; better understanding of the mimics of IBD; significant progress in clinical management; and modifications of terminology. Accordingly, an update is required. These revised guidelines aim to optimise the quality and consistency of reporting of biopsies taken for the initial diagnosis of IBD by summarising the literature and making recommendations based on the available evidence. Advice from existing clinical guidelines is also taken into account. Among the subjects discussed are: distinguishing IBD from other colitides, particularly infective colitis; subclassification of IBD (as ulcerative colitis, Crohn's disease, or IBD unclassified); the discriminant value of granulomas; aspects of disease distribution, including discontinuity in ulcerative colitis; time-related changes; differences between paediatric and adult IBD; the role of ileal and upper gastrointestinal biopsies; differential diagnoses such as diverticular colitis and diversion proctocolitis; and dysplasia. The need to correlate the histological features with clinical and endoscopic findings is emphasised. An approach to the conclusion of an IBD biopsy report based on the acronym Pattern, Activity, Interpretation, Dysplasia (PAID) is suggested. The key recommendations are listed at the end of the document.
NAD(+)/NADH-sensitive quantum dots: applications to probe NAD(+)-dependent enzymes and to sense the RDX explosive.

Phenyl boronic acid-functionalized CdSe/ZnS quantum dots (QDs) were synthesized. The modified particles bind nicotinamide adenine dinucleotide (NAD(+)) or 1,4-dihydronicotinamide adenine dinucleotide (NADH). The NAD(+)-functionalized QDs are effectively quenched by an electron transfer process, while the NADH-modified QDs are inefficiently quenched by the reduced cofactor. These properties enable the implementation of the QDs for the fluorescence analysis of ethanol in the presence of alcohol dehydrogenase. The NADH-functionalized QDs were used for the optical analysis of the 1,3,5-trinitrotriazine, RDX explosive, with a detection limit that corresponded to 1 x 10(-10) M. We demonstrate cooperative optical and catalytic functions of the core-shell components of the QDs in the analysis of RDX.
Differential Cache-Collision Timing Attacks on AES with Applications to Embedded CPUs

This paper proposes a new type of cache-collision timing attacks on software implementations of AES. Our major technique is of differential nature and is based on the internal cryptographic properties of AES, namely, on the MDS property of the linear code providing the diffusion matrix used in the MixColumns transform. It is a chosen-plaintext attack where pairs of AES executions are treated differentially. The method can be easily converted into a chosen-ciphertext attack. We also thoroughly study the physical behavior of cache memory enabling this attack. On the practical side, we demonstrate that our theoretical findings lead to efficient realworld attacks on embedded systems implementing AES at the example of ARM9. As this is one of the most wide-spread embedded platforms today [7], our experimental results might make a revision of the practical security of many embedded applications with security functionality necessary. To our best knowledge, this is the first paper to study cache timing attacks on embedded systems.
A time-split nonhydrostatic atmospheric model for weather research and forecasting applications

The sub-grid-scale parameterization of clouds is one of the weakest aspects of weather and climate modeling today, and the explicit simulation of clouds will be one of the next major achievements in numerical weather prediction. Research cloud models have been in development over the last 45 years and they continue to be an important tool for investigating clouds, cloud-systems, and other small-scale atmospheric dynamics. The latest generation are now being used for weather prediction. The Advanced Research WRF (ARW) model, representative of this generation and of a class of models using explicit time-splitting integration techniques to efficiently integrate the Euler equations, is described in this paper. It is the first fully compressible conservative-form nonhydrostatic atmospheric model suitable for both research and weather prediction applications. Results are presented demonstrating its ability to resolve strongly nonlinear small-scale phenomena, clouds, and cloud systems. Kinetic energy spectra and other statistics show that the model is simulating small scales in numerical weather prediction applications, while necessarily removing energy at the gridscale but minimizing artificial dissipation at the resolved scales. Filtering requirements for atmospheric models and filters used in the ARW model are discussed. ! 2007 Elsevier Inc. All rights reserved.
Automatic Camera Calibration for Image Sequences of a Football Match

In the broadcast of sports events one can commonly see adds or logos that are not actually there – instead, they are inserted into the image, with the appropriate perspective representation, by means of specialized computer graphics hardware. Such techniques involve camera calibration and the tracking of objects in the scene. This article introduces an automatic camera calibration algorithm for a smooth sequence of images of a football (soccer) match taken in the penalty area near one of the goals. The algorithm takes special steps for the first scene in the sequence and then uses coherence to efficiently update camera parameters for the remaining images. The algorithm is capable of treating in real-time a sequence of images obtained from a TV broadcast, without requiring any specialized hardware.
Effect of Gamma Irradiation on Total Phenolic Content and in Vitro Antioxidant Activity of Pomegranate (Punica granatum L.) Peels

Pomegranate peels were studied for the effect of gamma irradiation on microbial decontamination along with its effect on total phenolic content and in vitro antioxidant activity. Gamma irradiation was applied at various dose levels (5.0, 10.0, 15.0 and 25.0 kGy) on pomegranate peel powder. Both the values of total phenolic content and in vitro antioxidant activity were positively correlated and showed a significant increase (p < 0.05) for 10.0 kGy irradiated dose level immediately after irradiation and 60 days of post irradiation storage. At 5.0 kGy and above dose level, gamma irradiation has reduced microbial count of pomegranate peel powder to nil. Post irradiation storage studies also showed that, the irradiated peel powder was microbiologically safe even after 90 days of storage period.
Combinatorial testing in software projects

Software systems continuously grow in size and code complexity, the latter most evident through greater component interconnectedness. This leaves more space for bugs which introduce risks such as exposure to security threats. Combinatorial testing looks for interaction failures in order to improve the system security and effectiveness guarantees. One of the most effective test selection approaches under combinatorial testing are experimental design extensions for software testing. Covering array test sets are compact while maintaining at the same time complete combinatorial coverage up to the desired level. Smaller test sets with customizable level of assurance can drive testing costs down substantially. The paper presents a survey of research into combinatorial testing suite factors while also identifying possible future research ideas.
Scapulothoracic stabilisation for winging of the scapula using strips of autogenous fascia lata.

We have used a modified technique in five patients to correct winging of the scapula caused by injury to the brachial plexus or the long thoracic nerve during transaxillary resection of the first rib. The procedure stabilises the scapulothoracic articulation by using strips of autogenous fascia lata wrapped around the 4th, 6th and 7th ribs at least two, and preferably three, times. The mean age of the patients at the time of operation was 38 years (26 to 47) and the mean follow-up six years and four months (three years and three months to 11 years). Satisfactory stability was achieved in all patients with considerable improvement in shoulder function. There were no complications.
Activating elicited agent knowledge: How robot and user features shape the perception of social robots

A recent theoretical framework on anthropomorphism emphasizes the role of elicited agent knowledge in anthropomorphic inferences about nonhuman entities. According to the Three-Factor Model of psychological Anthropomorphism, people use anthropocentric knowledge structures when judging unfamiliar objects (e.g., robots). In the present research, our goal was to manipulate the accessibility of such elicited agent knowledge by varying features of a robot's voice: Specifically, we examined effects of vocal cues that reflected both gender of robot (i.e., a male vs. female voice) and voice type (i.e., a human-like vs. robot-like voice). This was done to test the impact of these vocal features on anthropomorphic inferences about the robot and on human-robot interaction (HRI) acceptance. Our results demonstrate that a robot's vocal cues clearly influence subsequent judgments of the robot and particularly so, when participant gender taken into account. Implications of our research for robotics will be discussed.
Series THE UPDATED WHO CLASSIFICATION OF HEMATOLOGICAL MALIGNANCIES The 2016 revision to the World Health Organization classi fi cation of myeloid neoplasms and acute leukemia

Department of Pathology, Stanford University, Stanford, CA; Department of Pathology, Weill Cornell Medical College, New York, NY; Department of Pathology, Massachusetts General Hospital, Boston, MA; Institute of Pathology, University of Cologne, Cologne, Germany; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Section of Hematology/Oncology, University of Chicago, Chicago, IL; Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH; Department of Molecular Medicine, University of Pavia, and Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; and Department of Pathology, University of Chicago, Chicago, IL
A framework for a video analysis tool for suspicious event detection

This paper proposes a framework to aid video analysts in detecting suspicious activity within the tremendous amounts of video data that exists in today's world of omnipresent surveillance video. Ideas and techniques for closing the semantic gap between low-level machine readable features of video data and high-level events seen by a human observer are discussed. An evaluation of the event classification and diction technique is presented and future an experiment to refine this technique is proposed. These experiments are used as a lead to a discussion on the most optimal machine learning algorithm to learn the event representation scheme proposed in this paper.
Corneal Endothelial Alterations in Chronic Renal Failure.

To evaluate the corneal endothelial changes in patients with chronic renal failure.



A total of 128 corneas of 128 subjects were studied, and 3 groups were formed. The first, the dialyzed group, composed of 32 corneas of 32 patients; the second, the nondialyzed group, composed of 34 corneas of 34 patients; and the third, the age-matched control group, composed of 64 corneas of 64 healthy subjects were examined by a specular microscope and the endothelial parameters were compared. The dialyzed group (enhanced level of toxins in the blood) was further analyzed to assess the influence of blood urea, serum creatinine, serum calcium, and serum phosphorus including the duration of dialysis on corneal endothelium.



On comparing the 3 groups using analysis of variance and posthoc tests, a significant difference was found in the central corneal thickness (CCT) and endothelial cell density (CD) between the control (CCT: 506 ± 29 μm, CD: 2760 ± 304 cells/mm) and dialyzed groups (CCT: 549 ± 30 μm, CD: 2337 ± 324 cells/mm) [P < 0.001 (CCT); P < 0.001 (CD)]; control and nondialyzed groups (CCT: 524 ± 27 μm, CD: 2574 ± 260 cells/mm) [P = 0.023 (CCT); P = 0.016 (CD)]; and dialyzed and nondialyzed groups [P = 0.002 (CCT); P = 0.007 (CD)]. Using the linear generalized model, a significant correlation was found between the endothelial parameters and blood urea only [P = 0.006 (CCT), 0.002 (coefficient of variation), 0.022 (CD), and 0.026 (percentage of hexagonality)], although the correlation was poorly positive for CCT but poorly negative for the remaining endothelial parameters.



Corneal endothelial alteration is present in patients with chronic renal failure, more marked in patients undergoing hemodialysis and with raised blood urea level.
Organic Packages With Embedded Phased-Array Antennas for 60-GHz Wireless Chipsets

A multilayer organic package with embedded 60-GHz antennas and fully integrated with a 60-GHz phased-array transmitter or receiver chip is demonstrated. The package includes sixteen phased-array antennas, an open cavity for housing the flip-chip attached RF chip, and interconnects operating at DC-66 GHz. The 28 mm 28 mm ball grid array package is manufactured using printed circuit board processes and uses a combination of liquid-crystal polymer and glass-reinforced laminates, allowing excellent 60-GHz interconnect and antenna performance. The measured return loss and gain of each antenna from 56 to 66 GHz are and , respectively. Finally, the packaged transmitter and receiver chipsets, each working with a heat sink, have demonstrated beam-steered, non-line-of-sight links with data rates up to 5.3 Gb/s using 16-quadrature amplitude modulation single-carrier and orthogonal frequency division multiplexing schemes.
Brain2Image: Converting Brain Signals into Images

Reading the human mind has been a hot topic in the last decades, and recent research in neuroscience has found evidence on the possibility of decoding, from neuroimaging data, how the human brain works. At the same time, the recent rediscovery of deep learning combined to the large interest of scientific community on generative methods has enabled the generation of realistic images by learning a data distribution from noise. The quality of generated images increases when the input data conveys information on visual content of images. Leveraging on these recent trends, in this paper we present an approach for generating images using visually-evoked brain signals recorded through an electroencephalograph (EEG). More specifically, we recorded EEG data from several subjects while observing images on a screen and tried to regenerate the seen images. To achieve this goal, we developed a deep-learning framework consisting of an LSTM stacked with a generative method, which learns a more compact and noise-free representation of EEG data and employs it to generate the visual stimuli evoking specific brain responses.
 OurBrain2Image approach was trained and tested using EEG data from six subjects while they were looking at images from 40 ImageNet classes. As generative models, we compared variational autoencoders (VAE) and generative adversarial networks (GAN). The results show that, indeed, our approach is able to generate an image drawn from the same distribution of the shown images. Furthermore, GAN, despite generating less realistic images, show better performance than VAE, especially as concern sharpness. The obtained performance provides useful hints on the fact that EEG contains patterns related to visual content and that such patterns can be used to effectively generate images that are semantically coherent to the evoking visual stimuli.
A second-degree burn after MRI.

A 48-year-old Nicaraguan man underwent mag netic resonance imaging (MRI) 3 days after admission to a South Florida hospital for treatment of cellulitis of the right thigh with vancomycin. MRI had been ordered to evaluate for a possible drainable source of infection, as the clinical picture and duration of illness was worsening and longer than expected for typical uncomplicated cellulitis despite intravenous antibiotic therapy. The MRI showed multiple enlarged inguinal lymph nodes and cellulitis of the superfi cial soft tissues of the thigh without discrete drainable collections. After the procedure, the patient was noted to have a bullous lesion on each thigh, each lesion roughly 1 cm in diameter and fi lled with clear serous fl uid . He reported that his legs had been pressed together before entering the MRI machine and that he had felt a burning sensation in both thighs during the test. Examination confi rmed that the lesions indeed aligned with each other when he pressed his thighs together. Study of a biopsy of one of the lesions revealed subepidermal cell blisters with focal epidermal necrosis and coagulative changes in the superfi cial dermis, consistent with a thermal injury .