nils-herrmann/clean_scirepeval huggingface dataset:
Deep packet inspection using Cuckoo filter

Nowadays, Internet Service Providers (ISPs) have been depending on Deep Packet Inspection (DPI) approaches, which are the most precise techniques for traffic identification and classification. However, constructing high performance DPI approaches imposes a vigilant and an in-depth computing system design because the demands for the memory and processing power. Membership query data structures, specifically Bloom filter (BF), have been employed as a matching check tool in DPI approaches. It has been utilized to store signatures fingerprint in order to examine the presence of these signatures in the incoming network flow. The main issue that arise when employing Bloom filter in DPI approaches is the need to use k hash functions which, in turn, imposes more calculations overhead that degrade the performance. Consequently, in this paper, a new design and implementation for a DPI approach have been proposed. This DPI utilizes a membership query data structure called Cuckoo filter (CF) as a matching check tool. CF has many advantages over BF like: less memory consumption, less false positive rate, higher insert performance, higher lookup throughput, support delete operation. The achieved experiments show that the proposed approach offers better performance results than others that utilize Bloom filter.
Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells

This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy γ-radiation in a lethal (60)Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.
Throughput enhanced wireless in local loop (TWiLL): the architecture, protocols, and pricing schemes

Traditionally, voice communication over the local loop has been provided by wired systems. In particular, twisted pair has been the standard means of connection for homes and offices for several years. However in the recent past there has been an increased interest in the use of radio access technologies in local loops. Such systems which are now popular for their ease and low cost of installation and maintenance are called Wireless in Local Loop (WLL) systems. Subscribers' demands for greater capacity has grown over the years especially with the advent of the Internet. Wired local loops have responded to these increasing demands through the use of digital technologies such as ISDN and xDSL. Demands for enhanced data rates are being faced by WLL system operators too, thus entailing efforts towards more efficient bandwidth use. Multi-hop communication has already been studied extensively in Ad hoc network environments and has begun making forays into cellular systems as well. Multi-hop communication has been proven as one of the best ways to enhance throughput in a wireless network. Through this effort we study the issues involved in multi-hop communication in a wireless local loop system and propose a novel WLL architecture called Throughput enhanced Wireless in Local Loop (TWiLL). Through a realistic simulation model we show the tremendous performance improvement achieved by TWiLL over WLL. Traditional pricing schemes employed in single hop wireless networks cannot be applied in TWiLL -- a multi-hop environment. We also propose three novel cost reimbursement based pricing schemes which could be applied in such a multi-hop environment.
Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): blocking 5HT3 receptors enhances release of serotonin, norepinephrine, and acetylcholine.

Vortioxetine is an antidepressant with multiple pharmacologic modes of action at targets where serotonin neurons connect with other neurons. 5HT3 receptor antagonism is one of these actions, and this leads to increased release of norepinephrine (NE), acetylcholine (ACh), and serotonin (5HT) within various brain circuits.
Growth and development in thanatophoric dysplasia – an update 25 years later

KEY CLINICAL MESSAGE
Thanatophoric dysplasia is typically a neonatal lethal condition. However, for those rare individuals who do survive, there is the development of seizures, progression of craniocervical stenosis, ventilator dependence, and limitations in motor and cognitive abilities. Families must be made aware of these issues during the discussion of management plans.
Visual Programming and Parallel Computing

Visual programming arguably provides greater benefit in explicit parallel programming, particularly coarse grain MIMD programming, than in sequential programming. Explicitly parallel programs are multi-dimensional objects; the natural representations of a parallel program are annotated directed graphs: data flow graphs, control flow graphs, etc. where the nodes of the graphs are sequential computations. The execution of parallel programs is a directed graph of instances of sequential computations. A visually based (directed graph) representation of parallel programs is thus more natural than a pure text string language where multi-dimensional structures must be implicitly defined. The naturalness of the annotated directed graph representation of parallel programs enables methods for programming and debugging which are qualitatively different and arguably superior to the conventional practice based on pure text string languages. Annotation of the graphs is a critical element of a practical visual programming system; text is still the best way to represent many aspects of programs. This paper presents a model of parallel programming and a model of execution for parallel programs which are the conceptual framework for a complete visual programming environment including capture of parallel structure, compilation and behavior analysis (performance and debugging). Two visually-oriented parallel programming systems, CODE 2.0 and HeNCE, each based on a variant of the model of programming, will be used to illustrate the concepts. The benefits of visually-oriented realizations of these models for program structure capture, software component reuse, performance analysis and debugging will be explored and hopefully demonstrated by examples in these representations. It is only by actually implementing and using visual parallel programming languages that we have been able to fully evaluate their merits.
STOPP/START criteria for potentially inappropriate prescribing in older people: version 2

Screening tool of older people's prescriptions (STOPP) and screening tool to alert to right treatment (START) criteria were first published in 2008. Due to an expanding therapeutics evidence base, updating of the criteria was required.



We reviewed the 2008 STOPP/START criteria to add new evidence-based criteria and remove any obsolete criteria. A thorough literature review was performed to reassess the evidence base of the 2008 criteria and the proposed new criteria. Nineteen experts from 13 European countries reviewed a new draft of STOPP & START criteria including proposed new criteria. These experts were also asked to propose additional criteria they considered important to include in the revised STOPP & START criteria and to highlight any criteria from the 2008 list they considered less important or lacking an evidence base. The revised list of criteria was then validated using the Delphi consensus methodology.



The expert panel agreed a final list of 114 criteria after two Delphi validation rounds, i.e. 80 STOPP criteria and 34 START criteria. This represents an overall 31% increase in STOPP/START criteria compared with version 1. Several new STOPP categories were created in version 2, namely antiplatelet/anticoagulant drugs, drugs affecting, or affected by, renal function and drugs that increase anticholinergic burden; new START categories include urogenital system drugs, analgesics and vaccines.



STOPP/START version 2 criteria have been expanded and updated for the purpose of minimizing inappropriate prescribing in older people. These criteria are based on an up-to-date literature review and consensus validation among a European panel of experts.
China's health system performance

We created a comprehensive set of health-system performance measurements for China nationally and regionally, with health-system coverage and catastrophic medical spending as major indicators. With respect to performance of health-care delivery, China has done well in provision of maternal and child health services, but poorly in addressing non-communicable diseases. For example, coverage of hospital delivery increased from 20% in 1993 to 62% in 2003 for women living in rural areas. However, effective coverage of hypertension treatment was only 12% for patients living in urban areas and 7% for those in rural areas in 2004. With respect to performance of health-care financing, 14% of urban and 16% of rural households incurred catastrophic medical expenditure in 2003. Furthermore, 15% of urban and 22% of rural residents had affordability difficulties when accessing health care. Although health-system coverage improved for both urban and rural areas from 1993 to 2003, affordability difficulties had worsened in rural areas. Additionally, substantial inter-regional and intra-regional inequalities in health-system coverage and health-care affordability measures exist. People with low income not only receive lower health-system coverage than those with high income, but also have an increased probability of either not seeking health care when ill or undergoing catastrophic medical spending. China's current health-system reform efforts need to be assessed for their effect on performance indicators, for which substantial data gaps exist.
Case report: Etizolam and its major metabolites in two unnatural death cases.

A simultaneous analytical method for etizolam and its main metabolites (alpha-hydroxyetizolam and 8-hydroxyetizolam) in whole blood was developed using solid-phase extraction, TMS derivatization and ion trap gas chromatography tandem mass spectrometry (GC-MS/MS). Separation of etizolam, TMS derivatives of alpha-hydroxyetizolam and 8-hydroxyetizolam and fludiazepam as internal standard was performed within about 17 min. The inter-day precision evaluated at the concentration of 50 ng/mL etizolam, alpha-hydroxyetizolam and 8-hydroxyetizolam was evaluated 8.6, 6.4 and 8.0% respectively. Linearity occurred over the range in 5-50 ng/mL. This method is satisfactory for clinical and forensic purposes. This method was applied to two unnatural death cases suspected to involve etizolam. Etizolam and its two metabolites were detected in these cases.
Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications

Cyclic GMP (cGMP) modulates important cerebral processes including some forms of learning and memory. cGMP pathways are strongly altered in hyperammonemia and hepatic encephalopathy (HE). Patients with liver cirrhosis show reduced intracellular cGMP in lymphocytes, increased cGMP in plasma and increased activation of soluble guanylate cyclase by nitric oxide (NO) in lymphocytes, which correlates with minimal HE assessed by psychometric tests. Activation of soluble guanylate cyclase by NO is also increased in cerebral cortex, but reduced in cerebellum, from patients who died with HE. This opposite alteration is reproduced in vivo in rats with chronic hyperammonemia or HE. A main pathway modulating cGMP levels in brain is the glutamate-NO-cGMP pathway. The function of this pathway is impaired both in cerebellum and cortex of rats with hyperammonemia or HE. Impairment of this pathway is responsible for reduced ability to learn some types of tasks. Restoring the pathway and cGMP levels in brain restores learning ability. This may be achieved by administering phosphodiesterase inhibitors (zaprinast, sildenafil), cGMP, anti-inflammatories (ibuprofen) or antagonists of GABAA receptors (bicuculline). These data support that increasing cGMP by safe pharmacological means may be a new therapeutic approach to improve cognitive function in patients with minimal or clinical HE.
Potential and challenges of zeolite chemistry in the catalytic conversion of biomass.

Increasing demand for sustainable chemicals and fuels has pushed academia and industry to search for alternative feedstocks replacing crude oil in traditional refineries. As a result, an immense academic attention has focused on the valorisation of biomass (components) and derived intermediates to generate valuable platform chemicals and fuels. Zeolite catalysis plays a distinct role in many of these biomass conversion routes. This contribution emphasizes the progress and potential in zeolite catalysed biomass conversions and relates these to concepts established in existing petrochemical processes. The application of zeolites, equipped with a variety of active sites, in Brønsted acid, Lewis acid, or multifunctional catalysed reactions is discussed and generalised to provide a comprehensive overview. In addition, the feedstock shift from crude oil to biomass involves new challenges in developing fields, like mesoporosity and pore interconnectivity of zeolites and stability of zeolites in liquid phase. Finally, the future challenges and perspectives of zeolites in the processing of biomass conversion are discussed.
The dopamine agonist piribedil exerts hepatoprotective effects on carbon tetrachloride-induced hepatic damage

This study aimed to investigate the effect of piribedil, a drug used for the treatment of Parkinson’s disease and which has direct dopaminergic stimulating action, on the acute hepatic injury in mice. Hepatotoxicity was induced by CCl4 orally (0.28 ml/kg). Piribedil at three dose levels (4.5, 9, or 18 mg/kg) or silymarin (25 mg/kg) was given orally daily for 7 days, starting at time of administration of CCl4. Liver damage was assessed by determining liver serum enzyme activities and by hepatic histopathology. Piribedil administration lessened the increases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) and also prevented the development of hepatic necrosis caused by CCl4. The effect of piribedil was dose-dependent one. Piribedil administered at the above doses caused significant reduction in the elevated plasma ALT by −36.3%, −42.8%, and −52.4% and ALP by −25%, −36.9%, and −57.1%, respectively. AST decreased by −36.4% and −46.2% by piribedil at 9 or 18 mg/kg, respectively. In comparison, the elevated serum ALT, AST, and ALP levels decreased to −69.6%, −64.2%, and −68.5% of control values, respectively, by silymarin. Histopathologic examination of the livers of CCl4-treated mice administered piribedil at 9 mg/kg showed noticeable amelioration of the liver tissue damage, while piribedil at 18 mg/kg resulted in restoration of the normal architecture of the liver tissue as well as noticeable increase in the protein content of hepatocytes. It is concluded that administration of the dopaminergic agonist piribedil in a model of liver injury induced by CCl4 results in amelioration of liver damage.
Revisiting the definition of animal tool use

Benjamin Beck’s definition of tool use has served the field of animal cognition well for over 25 years (Beck 1980,  the Use and Manufacture of Tools, New York, Garland STPM). This article proposes a new, more explanatory definition that accounts for tool use in terms of two complementary subcategories of behaviours: behaviours aimed at altering a target object by mechanical means and behaviours that mediate the flow of information between the tool user and the environment or other organisms in the environment. The conceptual foundation and implications of the new definition are contrasted with those of existing definitions, particularly Beck’s. The new definition is informally evaluated with respect to a set of scenarios that highlights differences from Beck’s definition as well as those of others in the literature.
A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis.

Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of lung cancer that urgently needs biomarkers to aid patient management. Here, we undertook the first comprehensive investigation on microRNA in Chinese SCC patients.



MicroRNA expression was measured in cancerous and noncancerous tissue pairs strictly collected from Chinese SCC patients (stages I-III), who had not been treated with chemotherapy or radiotherapy prior to surgery. The molecular targets of proposed microRNA were further examined.



We identified a 5-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a, and hsa-miR-140-3p) that could distinguish SCC from normal lung tissues. The classifier had an accuracy of 94.1% in a training cohort (34 patients) and 96.2% in a test cohort (26 patients). We also showed that high expression of hsa-miR-31 was associated with poor survival in these 60 SCC patients by Kaplan-Meier analysis (P = 0.007), by univariate Cox analysis (P = 0.011), and by multivariate Cox analysis (P = 0.011). This association was independently validated in a separate cohort of 88 SCC patients (P = 0.008, 0.011, and 0.003 in Kaplan-Meier analysis, univariate Cox analysis, and multivariate Cox analysis, respectively). We then determined that the tumor suppressor DICER1 is a target of hsa-miR-31. Expression of hsa-miR-31 in a human lung cancer cell line repressed DICER1 activity but not PPP2R2A or LATS2.



Our results identified a new diagnostic microRNA classifier for SCC among Chinese patients and a new prognostic biomarker, hsa-miR-31.
3D reconstruction of a smooth articulated trajectory from a monocular image sequence

An articulated trajectory is defined as a trajectory that remains at a fixed distance with respect to a parent trajectory. In this paper, we present a method to reconstruct an articulated trajectory in three dimensions given the two dimensional projection of the articulated trajectory, the 3D parent trajectory, and the camera pose at each time instant. This is a core challenge in reconstructing the 3D motion of articulated structures such as the human body because endpoints of each limb form articulated trajectories. We simultaneously apply activity-independent spatial and temporal constraints, in the form of fixed 3D distance to the parent trajectory and smooth 3D motion. There exist two solutions that satisfy each instantaneous 2D projection and articulation constraint (a ray intersects a sphere at up to two locations) and we show that resolving this ambiguity by enforcing smoothness is equivalent to solving a binary quadratic programming problem. A geometric analysis of the reconstruction of articulated trajectories is also presented and a measure of the reconstructibility of an articulated trajectory is proposed.
Animation and control of breaking waves

Controlling fluids is still an open and challenging problem in fluid animation. In this paper we develop a novel fluid animation control approach and we present its application to controlling breaking waves. In our <i>Slice Method</i> framework an animator defines the shape of a breaking wave at a desired moment in its evolution based on a library of breaking waves. Our system computes then the subsequent dynamics with the aid of a 3D Navier-Stokes solver. The wave dynamics previous to the moment the animator exerts control can also be generated based on the wave library. The animator is thus enabled to obtain a full animation of a breaking wave while controlling the shape and the timing of the breaking. An additional advantage of the method is that it provides a significantly faster method for obtaining the full 3D breaking wave evolution compared to starting the simulation at an early stage and using solely the 3D Navier-Stokes equations. We present a series of 2D and 3D breaking wave animations to demonstrate the power of the method.
Image Super-Resolution with Fast Approximate Convolutional Sparse Coding

We present a computationally e cient architecture for image super-resolution that achieves state-of-the-art results on images with large spatial extend. Apart from utilizing Convolutional Neural Networks, our approach leverages recent advances in fast approximate inference for sparse coding. We empirically show that upsampling methods work much better on latent representations than in the original spatial domain. Our experiments indicate that the proposed architecture can serve as a basis for additional future improvements in image superresolution.
Efficacy of Mobile Apps to Support the Care of Patients With Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Diabetes Mellitus (DM) is a chronic disease that is considered a global public health problem. Education and self-monitoring by diabetic patients help to optimize and make possible a satisfactory metabolic control enabling improved management and reduced morbidity and mortality. The global growth in the use of mobile phones makes them a powerful platform to help provide tailored health, delivered conveniently to patients through health apps.



The aim of our study was to evaluate the efficacy of mobile apps through a systematic review and meta-analysis to assist DM patients in treatment.



We conducted searches in the electronic databases MEDLINE (Pubmed), Cochrane Register of Controlled Trials (CENTRAL), and LILACS (Latin American and Caribbean Health Sciences Literature), including manual search in references of publications that included systematic reviews, specialized journals, and gray literature. We considered eligible randomized controlled trials (RCTs) conducted after 2008 with participants of all ages, patients with DM, and users of apps to help manage the disease. The meta-analysis of glycated hemoglobin (HbA1c) was performed in Review Manager software version 5.3.



The literature search identified 1236 publications. Of these, 13 studies were included that evaluated 1263 patients. In 6 RCTs, there were a statistical significant reduction (P<.05) of HbA1c at the end of studies in the intervention group. The HbA1c data were evaluated by meta-analysis with the following results (mean difference, MD -0.44; CI: -0.59 to -0.29; P<.001; I²=32%).The evaluation favored the treatment in patients who used apps without significant heterogeneity.



The use of apps by diabetic patients could help improve the control of HbA1c. In addition, the apps seem to strengthen the perception of self-care by contributing better information and health education to patients. Patients also become more self-confident to deal with their diabetes, mainly by reducing their fear of not knowing how to deal with potential hypoglycemic episodes that may occur.