nils-herrmann/clean_scirepeval huggingface dataset:
Fluorescence anisotropy (polarization): from drug screening to precision medicine.

Fluorescence anisotropy (FA) is one of the major established methods accepted by industry and regulatory agencies for understanding the mechanisms of drug action and selecting drug candidates utilizing a high-throughput format.



This review covers the basics of FA and complementary methods, such as fluorescence lifetime anisotropy and their roles in the drug discovery process. The authors highlight the factors affecting FA readouts, fluorophore selection and instrumentation. Furthermore, the authors describe the recent development of a successful, commercially valuable FA assay for long QT syndrome drug toxicity to illustrate the role that FA can play in the early stages of drug discovery.



Despite the success in drug discovery, the FA-based technique experiences competitive pressure from other homogeneous assays. That being said, FA is an established yet rapidly developing technique, recognized by academic institutions, the pharmaceutical industry and regulatory agencies across the globe. The technical problems encountered in working with small molecules in homogeneous assays are largely solved, and new challenges come from more complex biological molecules and nanoparticles. With that, FA will remain one of the major work-horse techniques leading to precision (personalized) medicine.
ICE-TEA: In-Context Expansion and Translation of English Abbreviations

The wide use of abbreviations in modern texts poses interesting challenges and opportunities in the field of NLP. In addition to their dynamic nature, abbreviations are highly polysemous with respect to regular words. Technologies that exhibit some level of language understanding may be adversely impacted by the presence of abbreviations. This paper addresses two related problems: (1) expansion of abbreviations given a context, and (2) translation of sentences with abbreviations. First, an efficient retrieval-based method for English abbreviation expansion is presented. Then, a hybrid system is used to pick among simple abbreviation-translation methods. The hybrid system achieves an improvement of 1.48 BLEU points over the baseline MT system, using sentences that contain abbreviations as a test set.
A classification of data quality assessment methods

Data quality (DQ) assessment can be significantly enhanced with the use of the right DQ assessment methods, which provide automated solutions to assess DQ. The range of DQ assessment methods is very broad: from data profiling and semantic profiling to data matching and data validation. This paper gives an overview of current methods for DQ assessment and classifies the DQ assessment methods into an existing taxonomy of DQ problems. Specific examples of the placement of each DQ method in the taxonomy are provided and illustrate why the method is relevant to the particular taxonomy position. The gaps in the taxonomy, where no current DQ methods exist, show where new methods are required and can guide future research and DQ tool development.
Plyometric training in female athletes. Decreased impact forces and increased hamstring torques.

The purpose of this study was to test the effect of a jump-training program on landing mechanics and lower extremity strength in female athletes involved in jumping sports. These parameters were compared before and after training with those of male athletes. The program was designed to decrease landing forces by teaching neuromuscular control of the lower limb during landing and to increase vertical jump height. After training, peak landing forces from a volleyball block jump decreased 22%, and knee adduction and abduction moments (medially and laterally directed torques) decreased approximately 50%. Multiple regression analysis revealed that these moments were significant predictors of peak landing forces. Female athletes demonstrated lower landing forces than male athletes and lower adduction and abduction moments after training. External knee extension moments (hamstring muscle-dominant) of male athletes were threefold higher than those of female athletes. Hamstring-to-quadriceps muscle peak torque ratios increased 26% on the nondominant side and 13% on the dominant side, correcting side-to-side imbalances. Hamstring muscle power increased 44% with training on the dominant side and 21% on the nondominant. Peak torque ratios of male athletes were significantly greater than those of untrained female athletes, but similar to those of trained females. Mean vertical jump height increased approximately 10%. This training may have a significant effect on knee stabilization and prevention of serious knee injury among female athletes.
A Market in Your Social Network: The Effects of Extrinsic Rewards on Friendsourcing and Relationships

Friendsourcing consists of broadcasting questions and help requests to friends on social networking sites. Despite its potential value, friendsourcing requests often fall on deaf ears. One way to improve response rates and motivate friends to undertake more effortful tasks may be to offer extrinsic rewards, such as money or a gift, for responding to friendsourcing requests. However, past research suggests that these extrinsic rewards can have unintended consequences, including undermining intrinsic motivations and undercutting the relationship between people. To explore the effects of extrinsic reward on friends' response rate and perceived relationship, we conducted an experiment on a new friendsourcing platform - Mobilyzr. Results indicate that large extrinsic rewards increase friends' response rates without reducing the relationship strength between friends. Additionally, the extrinsic rewards allow requesters to explain away the failure of friendsourcing requests and thus preserve their perceptions of relationship ties with friends.
Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain.

The pathophysiology of perinatal brain injury is multifactorial and involves hypoxia-ischemia (HI) and inflammation. N-methyl-d-aspartate receptors (NMDAR) are present on neurons and glia in immature rodents, and NMDAR antagonists are protective in HI models. To enhance clinical translation of rodent data, we examined protein expression of 6 NMDAR subunits in postmortem human brains without injury from 20 postconceptional weeks through adulthood and in cases of periventricular leukomalacia (PVL). We hypothesized that the developing brain is intrinsically vulnerable to excitotoxicity via maturation-specific NMDAR levels and subunit composition. In normal white matter, NR1 and NR2B levels were highest in the preterm period compared with adult. In gray matter, NR2A and NR3A expression were highest near term. NR2A was significantly elevated in PVL white matter, with reduced NR1 and NR3A in gray matter compared with uninjured controls. These data suggest increased NMDAR-mediated vulnerability during early brain development due to an overall upregulation of individual receptors subunits, in particular, the presence of highly calcium permeable NR2B-containing and magnesium-insensitive NR3A NMDARs. These data improve understanding of molecular diversity and heterogeneity of NMDAR subunit expression in human brain development and supports an intrinsic prenatal vulnerability to glutamate-mediated injury; validating NMDAR subunit-specific targeted therapies for PVL.
Robust Online Monitoring of Signal Temporal Logic

Signal Temporal Logic (STL) is a formalism used to rigorously specify requirements of cyberphysical systems (CPS), i.e., systems mixing digital or discrete components in interaction with a continuous environment or analog components. STL is naturally equipped with a quantitative semantics which can be used for various purposes: from assessing the robustness of a specification to guiding searches over the input and parameter space with the goal of falsifying the given property over system behaviors. Algorithms have been proposed and implemented for offline computation of such quantitative semantics, but only few methods exist for an online setting, where one would want to monitor the satisfaction of a formula during simulation. In this paper, we formalize a semantics for robust online monitoring of partial traces, i.e., traces for which there might not be enough data to decide the Boolean satisfaction (and to compute its quantitative counterpart). We propose an efficient algorithm to compute it and demonstrate its usage on two large scale real-world case studies coming from the automotive domain and from CPS education in a Massively Open Online Course (MOOC) setting. We show that savings in computationally expensive simulations far outweigh any overheads incurred by an online approach.
Configurable toolset for static verification of operating systems kernel modules

An operating system (OS) kernel is a critical software regarding to reliability and efficiency. Quality of modern OS kernels is already high enough. However, this is not the case for kernel modules, like, for example, device drivers that, due to various reasons, have a significantly lower level of quality. One of the most critical and widespread bugs in kernel modules are violations of rules for correct usage of a kernel API. One can find all such violations in modules or can prove their correctness using static verification tools that need contract specifications describing obligations of a kernel and modules relative to each other. This paper considers present methods and toolsets for static verification of kernel modules for different OSs. A new method for static verification of Linux kernel modules is proposed. This method allows one to configure the verification process at all its stages. It is shown how it can be adapted for checking kernel components of other OSs. An architecture of a configurable toolset for static verification of Linux kernel modules that implements the proposed method is described, and results of its practical application are presented. Directions for further development of the proposed method are discussed in conclusion.
SERIES RELIGIOUS COMPETITION AND REALLOCATION : THE POLITICAL ECONOMY OF SECULARIZATION IN THE PROTESTANT REFORMATION

Using novel microdata, we document an unintended, first-order consequence of the Protestant Reformation: a massive reallocation of resources from religious to secular purposes. To understand this process, we propose a conceptual framework in which the introduction of religious competition shifts political markets where religious authorities provide legitimacy to rulers in exchange for control over resources. Consistent with our framework, religious competition changed the balance of power between secular and religious elites: secular authorities acquired enormous amounts of wealth from monasteries closed during the Reformation, particularly in Protestant regions. This transfer of resources had important consequences. First, it shifted the allocation of upper-tail human capital. Graduates of Protestant universities increasingly took secular, especially administrative, occupations. Protestant university students increasingly studied secular subjects, especially degrees that prepared students for public sector jobs, rather than church sector-specific theology. Second, it affected the sectoral composition of fixed investment. Particularly in Protestant regions, new construction shifted from religious toward secular purposes, especially the building of palaces and administrative buildings, which reflected the increased wealth and power of secular lords. Reallocation was not driven by preexisting economic or cultural differences. Our findings indicate that the Reformation played an important causal role in the secularization of the West. Davide Cantoni Seminar für Wirtschaftsgeschichte University of Munich 80539 Munich Germany Davide.Cantoni@econ.lmu.de Jeremiah Dittmar Centre for Economic Performance London School of Economics London WC2A 2AE United Kingdom dittmar.academic@gmail.com Noam Yuchtman Haas School of Business University of California, Berkeley Berkeley, CA 94720 and NBER yuchtman@haas.berkeley.edu
1 LINKING PRACTICE AND THEORY : THE PEDAGOGY OF REALISTIC TEACHER EDUCATION

Teacher education finds itself in a critical stage. The pressure towards more school-based programs which is visible in many countries is a sign that not only teachers, but also parents and politicians, are often dissatisfied with the traditional approaches in teacher education In some countries a major part of preservice teacher education has now become the responsibility of the schools, creating a situation in which to a large degree teacher education takes the form of 'training on the job'. The argument for this tendency is that traditional teacher education programs are said to fail in preparing prospective teachers for the realities of the classroom (Goodlad, 1990). Many teacher educators object that a professional teacher should acquire more than just practical tools for managing classroom situations and that it is their job to present student teachers with a broader view on education and to offer them a proper grounding in psychology, sociology, etcetera. This is what Clandinin (1995) calls " the sacred theory-practice story " : teacher education conceived as the translation of theory on good teaching into practice. However, many studies have shown that the transfer of theory to practice is meager or even non-existent. Zeichner and Tabachnick (1981), for example, showed that many notions and educational conceptions, developed during preservice teacher education, were "washed out" during field experiences. Comparable findings were reported by Cole and Knowles (1993) and Veenman (1984), who also points towards the severe problems teachers experience once they have left preservice teacher education. Lortie (1975) presented us with another early study into the socialization process of teachers, showing the dominant role of practice in shaping teacher development. At Konstanz University in Germany, research has been carried out into the phenomenon of the "transition shock" (Müller-Fohrbrodt et al. It showed that, during their induction in the profession, teachers encounter a huge gap between theory and practice. As a consequence, they pass through a quite distinct attitude shift during their first year of teaching, in general creating an adjustment to current practices in the schools and not to recent scientific insights into learning and teaching.
Micro-crack detection of multicrystalline solar cells featuring an improved anisotropic diffusion filter and image segmentation technique

This paper presents an algorithm for the detection of micro-crack defects in the multicrystalline solar cells. This detection goal is very challenging due to the presence of various types of image anomalies like dislocation clusters, grain boundaries, and other artifacts due to the spurious discontinuities in the gray levels. In this work, an algorithm featuring an improved anisotropic diffusion filter and advanced image segmentation technique is proposed. The methods and procedures are assessed using 600 electroluminescence images, comprising 313 intact and 287 defected samples. Results indicate that the methods and procedures can accurately detect micro-crack in solar cells with sensitivity, specificity, and accuracy averaging at 97%, 80%, and 88%, respectively.
Changed nursing scheduling for improved safety culture and working conditions - patients' and nurses' perspectives.

To evaluate fixed scheduling compared with self-scheduling for nursing staff in oncological inpatient care with regard to patient and staff outcomes.



Various scheduling models have been tested to attract and retain nursing staff. Little is known about how these schedules affect staff and patients. Fixed scheduling and self-scheduling have been studied to a small extent, solely from a staff perspective.



We implemented fixed scheduling on two of four oncological inpatient wards. Two wards kept self-scheduling. Through a quasi-experimental design, baseline and follow-up measurements were collected among staff and patients. The Safety Attitudes Questionnaire was used among staff, as well as study-specific questions for patients and staff.



Fixed scheduling was associated with less overtime and fewer possibilities to change shifts. Self-scheduling was associated with more requests from management for short notice shift changes. The type of scheduling did not affect patient-reported outcomes.



Fixed scheduling should be considered in order to lower overtime. Further research is necessary and should explore patient outcomes to a greater extent.



Scheduling is a core task for nurse managers. Our study suggests fixed scheduling as a strategy for managers to improve the effective use of resources and safety.
RIDI: Robust IMU Double Integration

This paper proposes a novel data-driven approach for inertial navigation, which learns to estimate trajectories of natural human motions just from an inertial measurement unit (IMU) in every smartphone. The key observation is that human motions are repetitive and consist of a few major modes (e.g., standing, walking, or turning). Our algorithm regresses a velocity vector from the history of linear accelerations and angular velocities, then corrects low-frequency bias in the linear accelerations, which are integrated twice to estimate positions. We have acquired training data with ground truth motion trajectories across multiple human subjects and multiple phone placements (e.g., in a bag or a hand). The qualitatively and quantitatively evaluations have demonstrated that our simple algorithm outperforms existing heuristic-based approaches and is even comparable to full Visual Inertial navigation to our surprise. As far as we know, this paper is the first to introduce supervised training for inertial navigation, potentially opening up a new line of research in the domain of data-driven inertial navigation. We will publicly share our code and data to facilitate further research.
Anti-inflammatory, antioxidant and antimicrobial activity of Ophthacare brand, an herbal eye drops.

In the present study, the herbal preparation of Ophthacare brand eye drops was investigated for its anti-inflammatory, antioxidant and antimicrobial activity, using in vivo and in vitro experimental models. Ophthacare brand eye drops exhibited significant anti-inflammatory activity in turpentine liniment-induced ocular inflammation in rabbits. The preparation dose-dependently inhibited ferric chloride-induced lipid peroxidation in vitro and also showed significant antibacterial activity against Escherichia coli and Staphylococcus aureus and antifungal activity against Candida albicans. All these findings suggest that Ophthacare brand eye drops can be used in the treatment of various ophthalmic disorders.
Teraohm pseudo-resistor experimental characterization aiming at implementation of bio-amplifiers

This paper describes the experimental characterization of MOS bipolar pseudo-resistors for a general purpose technology. Very-high resistance values can be obtained in small footprint layouts, allowing the development of high-pass filters with RC constants over 1 second. The pseudo-resistor presents two different behavior regions, and as described in this work, in bio-amplifiers applications, important functions are assigned to each of these regions. 0.13 μm 8HP technology from GlobalFoundries was chosen as the target technology for the prototypes, because of its versatility. Due to the very-low current of pseudo-resistors, a circuit for indirect resistance measurement was proposed and applied. The fabricated devices presented resistances over 1 teraohm and preserved both the linear and the exponential operation regions, proving that they are well suited for bio-amplifier applications.
Loss Analysis and Efficiency Improvement of an Axial-Flux PM Amorphous Magnetic Material Machine

This paper presents research work on a 12-slot ten-pole tapered axial-flux permanent-magnet machine utilizing amorphous magnetic material in the stator core. Novel loss separation techniques are described, including mechanical loss and locked-rotor tests. Mechanical loss estimation is based on a combination of experimental tests and 3-D finite-element model analysis using an uncut stator. The locked-rotor test is introduced to separate the stator and rotor losses by eliminating the uncertainty associated with mechanical loss. High rotor yoke losses were identified in the baseline design. The rotor design was modified and a significant improvement in efficiency was demonstrated.
Is It Time for Synthetic Biodiversity Conservation?

Evidence indicates that, despite some critical successes, current conservation approaches are not slowing the overall rate of biodiversity loss. The field of synthetic biology, which is capable of altering natural genomes with extremely precise editing, might offer the potential to resolve some intractable conservation problems (e.g., invasive species or pathogens). However, it is our opinion that there has been insufficient engagement by the conservation community with practitioners of synthetic biology. We contend that rapid, large-scale engagement of these two communities is urgently needed to avoid unintended and deleterious ecological consequences. To this point we describe case studies where synthetic biology is currently being applied to conservation, and we highlight the benefits to conservation biologists from engaging with this emerging technology.
A DC-20GHz attenuator design with RF MEMS technologies and distributed attenuation networks

In this paper we presented a design of 4 bit attenuator with RF MEMS switches and distributed attenuation networks. The substrate of this attenuator is high resistance silicon and the TaN thin film is used as resistors. RF MEMS switches have excellent microwave properties to reduce the insertion loss of attenuator and increase the insulation. Distributed attenuation networks employed as fixed attenuators have the advantages of smaller size and better performance in comparison to conventional π or T-type fixed attenuators. Over DC-20GHz, the simulation results show the attenuation flatness of 1.52-1.65dB and the attenuation range of 15.35-17.02dB. The minimum attenuation is 0.44-1.96dB in the interesting frequency range. The size of the attenuator is 2152 × 7500μm2.
A clinical comparison of variable-damping and mechanically passive prosthetic knee devices.

Although variable-damping knee prostheses offer some improvements over mechanically passive prostheses to transfemoral amputees, there is insufficient evidence that such prostheses provide advantages at self-selected walking speeds. In this investigation, we address this question by comparing two variable-damping knees, the hydraulic-based Otto Bock C-leg and the magnetorheological-based Ossur Rheo, with the mechanically passive, hydraulic-based Mauch SNS.



For each prosthesis, metabolic data were collected on eight unilateral amputees walking at self-selected speeds across an indoor track. Furthermore, kinetic, kinematic, and electromyographic data were collected while walking at self-selected speeds across a 10-m walkway in a laboratory.



When using the Rheo, metabolic rate decreases by 5% compared with the Mauch and by 3% compared with the C-leg. Furthermore, for the C-leg and Rheo knee devices, we observe biomechanical advantages over the mechanically passive Mauch. These advantages include an enhanced smoothness of gait, a decrease in hip work production, a lower peak hip flexion moment at terminal stance, and a reduction in peak hip power generation at toe-off.



The results of this study indicate that variable-damping knee prostheses offer advantages over mechanically passive designs for unilateral transfemoral amputees walking at self-selected ambulatory speeds, and the results further suggest that a magnetorheological-based system may have advantages over hydraulic-based designs.