nils-herrmann/clean_scirepeval huggingface dataset:
Opium poppy: blueprint for an alkaloid factory

Opium poppy (Papaver somniferum) produces a large number of benzylisoquinoline alkaloids, including the narcotic analgesics morphine and codeine, and has emerged as one of the most versatile model systems to study alkaloid metabolism in plants. As summarized in this review, we have taken a holistic strategy—involving biochemical, cellular, molecular genetic, genomic, and metabolomic approaches—to draft a blueprint of the fundamental biological platforms required for an opium poppy cell to function as an alkaloid factory. The capacity to synthesize and store alkaloids requires the cooperation of three phloem cell types—companion cells, sieve elements, and laticifers—in the plant, but also occurs in dedifferentiated cell cultures. We have assembled an opium poppy expressed sequence tag (EST) database based on the attempted sequencing of more than 30,000 cDNAs from elicitor-treated cell culture, stem, and root libraries. Approximately 23,000 of the elicitor-induced cell culture and stem ESTs are represented on a DNA microarray, which has been used to examine changes in transcript profile in cultured cells in response to elicitor treatment, and in plants with different alkaloid profiles. Fourier transform-ion cyclotron resonance mass spectrometry and proton nuclear magnetic resonance mass spectroscopy are being used to detect corresponding differences in metabolite profiles. Several new genes involved in the biosynthesis and regulation of alkaloid pathways in opium poppy have been identified using genomic tools. A biological blueprint for alkaloid production coupled with the emergence of reliable transformation protocols has created an unprecedented opportunity to alter the chemical profile of the world’s most valuable medicinal plant.
β-Cell–Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice

Interleukin-2 (IL-2) is a critical cytokine for the homeostasis and function of forkhead box p3-expressing regulatory T cells (Foxp3(+)Tregs). Dysregulation of the IL-2-IL-2 receptor axis is associated with aberrant Foxp3(+)Tregs and T cell-mediated autoimmune diseases such as type 1 diabetes. Treatment with recombinant IL-2 has been reported to enhance Foxp3(+)Tregs and suppress different models of autoimmunity. However, efficacy of IL-2 therapy is dependent on achieving sufficient levels of IL-2 to boost tissue-resident Foxp3(+)Tregs while avoiding the potential toxic effects of systemic IL-2. With this in mind, adeno-associated virus (AAV) vector gene delivery was used to localize IL-2 expression to the islets of NOD mice. Injection of a double-stranded AAV vector encoding IL-2 driven by a mouse insulin promoter (dsAAVmIP-IL2) increased Foxp3(+)Tregs in the islets but not the draining pancreatic lymph nodes. Islet Foxp3(+)Tregs in dsAAVmIP-IL2-treated NOD mice exhibited enhanced fitness marked by increased expression of Bcl-2, proliferation, and suppressor function. In contrast, ectopic IL-2 had no significant effect on conventional islet-infiltrating effector T cells. Notably, β-cell-specific IL-2 expression suppressed late preclinical type 1 diabetes in NOD mice. Collectively, these findings demonstrate that β-cell-specific IL-2 expands an islet-resident Foxp3(+)Tregs pool that effectively suppresses ongoing type 1 diabetes long term.
ALGORITHMIC TRADING WITH MARKOV CHAINS

An order book consists of a list of all buy and sell offers, represented by price and quantity, available to a market agent. The order book changes rapidly, within fractions of a second, due to new orders being entered into the book. The volume at a certain price level may increase due to limit orders, i.e. orders to buy or sell placed at the end of the queue, or decrease because of market orders or cancellations. In this paper a high-dimensional Markov chain is used to represent the state and evolution of the entire order book. The design and evaluation of optimal algorithmic strategies for buying and selling is studied within the theory of Markov decision processes. General conditions are provided that guarantee the existence of optimal strategies. Moreover, a value-iteration algorithm is presented that enables finding optimal strategies numerically. As an illustration a simple version of the Markov chain model is calibrated to high-frequency observations of the order book in a foreign exchange market. In this model, using an optimally designed strategy for buying one unit provides a significant improvement, in terms of the expected buy price, over a naive buy-one-unit strategy.
Growing up with parental alcohol abuse: exposure to childhood abuse, neglect, and household dysfunction.

This study is a detailed examination of the association between parental alcohol abuse (mother only, father only, or both parents) and multiple forms of childhood abuse, neglect, and other household dysfunction, known as adverse childhood experiences (ACEs).



A questionnaire about ACEs including child abuse, neglect, household dysfunction, and exposure to parental alcohol abuse was completed by 8629 adult HMO members to retrospectively assess the relationship of growing up with parental alcohol abuse to 10 ACEs and multiple ACEs (ACE score).



Compared to persons who grew up with no parental alcohol abuse, the adjusted odds ratio for each category of ACE was approximately 2 to 13 times higher if either the mother, father, or both parents abused alcohol (p < 0.05). For example, the likelihood of having a battered mother was increased 13-fold for men who grew up with both parents who abused alcohol (OR, 12.7; 95% CI: 8.4-19.1). For almost every ACE, those who grew up with both an alcohol-abusing mother and father had the highest likelihood of ACEs. The mean number of ACEs for persons with no parental alcohol abuse, father only, mother only, or both parents was 1.4, 2.6, 3.2, and 3.8, respectively (p < .001).



Although the retrospective reporting of these experiences cannot establish a causal association with certainty, exposure to parental alcohol abuse is highly associated with experiencing adverse childhood experiences. Improved coordination of adult and pediatric health care along with related social and substance abuse services may lead to earlier recognition, treatment, and prevention of both adult alcohol abuse and adverse childhood experiences, reducing the negative sequelae of ACEs in adolescents and adults.
Selecting non-zero weights to evaluate effectiveness of basketball players with DEA

In this paper, we show how DEA may be used to identify component profiles as well as overall indices of performance in the context of an application to assessments of basketball players. We go beyond the usual uses of DEA to provide only overall indexes of performance. Our focus is, instead, on the multiplier values for the efficiently rated players. For this purpose we use a procedure that we recently developed that guarantees a full profile of non-zero weights, or ‘‘multipliers.” We demonstrate how these values can be used to identify relative strengths and weaknesses in individual players. Here we also utilize the flexibility of DEA by introducing bounds on the allowable values to reflect the views of coaches, trainers and other experts on the basketball team for which evaluations are being conducted. Finally we show how these combinations can be extended by taking account of team as well as individual considerations.
The evolution of functional hand replacement: From iron prostheses to hand transplantation.

The hand is an integral component of the human body, with an incredible spectrum of functionality. In addition to possessing gross and fine motor capabilities essential for physical survival, the hand is fundamental to social conventions, enabling greeting, grooming, artistic expression and syntactical communication. The loss of one or both hands is, thus, a devastating experience, requiring significant psychological support and physical rehabilitation. The majority of hand amputations occur in working-age males, most commonly as a result of work-related trauma or as casualties sustained during combat. For millennia, humans have used state-of-the-art technology to design clever devices to facilitate the reintegration of hand amputees into society. The present article provides a historical overview of the progress in replacing a missing hand, from early iron hands intended primarily for use in battle, to today's standard body-powered and myoelectric prostheses, to revolutionary advancements in the restoration of sensorimotor control with targeted reinnervation and hand transplantation.
BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill.

This review article describes two protocols adapted from lung ultrasound: the bedside lung ultrasound in emergency (BLUE)-protocol for the immediate diagnosis of acute respiratory failure and the fluid administration limited by lung sonography (FALLS)-protocol for the management of acute circulatory failure. These applications require the mastery of 10 signs indicating normal lung surface (bat sign, lung sliding, A-lines), pleural effusions (quad and sinusoid sign), lung consolidations (fractal and tissue-like sign), interstitial syndrome (lung rockets), and pneumothorax (stratosphere sign and the lung point). These signs have been assessed in adults, with diagnostic accuracies ranging from 90% to 100%, allowing consideration of ultrasound as a reasonable bedside gold standard. In the BLUE-protocol, profiles have been designed for the main diseases (pneumonia, congestive heart failure, COPD, asthma, pulmonary embolism, pneumothorax), with an accuracy > 90%. In the FALLS-protocol, the change from A-lines to lung rockets appears at a threshold of 18 mm Hg of pulmonary artery occlusion pressure, providing a direct biomarker of clinical volemia. The FALLS-protocol sequentially rules out obstructive, then cardiogenic, then hypovolemic shock for expediting the diagnosis of distributive (usually septic) shock. These applications can be done using simple grayscale machines and one microconvex probe suitable for the whole body. Lung ultrasound is a multifaceted tool also useful for decreasing radiation doses (of interest in neonates where the lung signatures are similar to those in adults), from ARDS to trauma management, and from ICUs to points of care. If done in suitable centers, training is the least of the limitations for making use of this kind of visual medicine.
Gigantomastia complicating mirror syndrome in pregnancy.

Gigantomastia is a rare and dangerous condition in pregnancy. Although improvement after delivery is likely, postpartum aggravation is possible. To date, various pharmacological approaches have been tried, with only marginal effectiveness. Surgical intervention is often necessary.



A young woman presented at 32 weeks' gestation with mirror syndrome and gigantomastia. Two years earlier she had had reduction mammoplasty by free nipple transplant. She delivered by cesarean. Rapid postpartum progression of gigantomastia led to breast necrosis and sepsis. The clinical course was complicated by acute respiratory distress syndrome and renal failure. Emergent bilateral simple mastectomy was performed, with subsequent clinical improvement.



When this devastating condition occurs in pregnancy or postpartum, urgent surgical intervention may prevent potentially fatal complications.
Turn-on loss vs. free-wheel diode recovery dv/dt in IGBT modules

The latest 6th generation Carrier Stored Trench Gate Bipolar Transistor (CSTBT™) provides state of the art optimization of conduction and switching losses in IGBT modules. Use of low values of resistance in series with the IGBT gate produces low turn-on losses but increases stress on the recovery of the free-wheel diode resulting in higher dv/dt and increased EMI. The latest modules also incorporate new, improved recovery free-wheel diode chips which improve this situation but detailed evaluation of the trade-off between turn-on loss and dv/dt performance is required. This paper describes the evaluation, test results, and a comparative analysis of dv/dt versus turn-on loss as a function of gate drive conditions for the 6th generation IGBT compared to the standard 5th generation module.
What leads to post-implementation success of ERP? An empirical study of the Chinese retail industry

Enterprise Resource Planning (ERP) systems have been implemented globally and their implementation has been extensively studied during the past decade. However, many organizations are still struggling to derive benefits from the implemented ERP systems. Therefore, ensuring post-implementation success has become the focus of the current ERP research. This study develops an integrative model to explain the post-implementation success of ERP, based on the Technology–Organization–Environment (TOE) theory. We posit that ERP implementation quality (the technological aspect) consisting of project management and system configuration, organizational readiness (the organizational aspect) consisting of leadership involvement and organizational fit, and external support (the environmental aspect) will positively affect the post-implementation success of ERP. An empirical test was conducted in the Chinese retail industry. The results show that both ERP implementation quality and organizational readiness significantly affect post-implementation success, whereas external support does not. The theoretical and practical implications of the findings are discussed.
Automatic Question Generation Using Software Agents for Technical Institutions

In the attempt of producing quality graduates, a major factor that needs a considerable amount of attention is the institutions evaluation system. Now, in order to produce quality result their examination system must be very effective, questions must be able to assess students in every domain. Preparation of question paper with high standard that really kindles the student’s thinking ability is very challengeable task that need to be performed by the academicians. There arises a need for automatic question generation. For all the existing automatic question generating systems, the problem lies either in eliminating the user’s role or in developing factual questions based on Bloom’s taxonomy. To overcome these issues, in the proposed system, the focus is to take input in form of a text file from user which contains of the text upon which the user desires to fetch questions; the output is produced in form of a text file containing questions based on Bloom’s taxonomy. The entire process is carried out by software agents, which eliminates the major problems of existing systems.
High isolation and compact size microstrip hairpin diplexer

Since conventional microstrip hairpin filter and diplexer are inherently formed by coupled-line resonators, spurious response and poor isolation performance are unavoidable. This letter presents a simple technique that is suitable for an inhomogeneous structure such as microstrip to cure such poor performances. The technique is based on the stepped impedance coupled-line resonator and is verified by the experimental results of the designed 0.9GHz/1.8GHz microstrip hairpin diplexer.
A Low Profile and Low Sidelobe Wideband Slot Antenna Array Feb by an Amplitude-Tapering Waveguide Feed-Network

A low profile slot antenna array is designed to operate over a wide bandwidth with low sidelobe levels. Taylor synthesis is used to taper the power distribution among array aperture. An efficient approach to design an equal-phase but unequal-power symmetric waveguide divider is proposed for constructing an amplitude-tapering feed-network for the array. Phase differences are balanced by adjusting the waveguide phase velocities. The basic radiator is a 2 × 2 slot subarray, uniformly fed by such a waveguide divider. A 16 × 16 array is then constructed by 8 × 8 of such subarrays. A 1-to-64 way corporate-feed waveguide network is designed to excite all subarrays instead of individual slots, and the required power distribution is obtained by adopting a 30 dB Taylor N̅ = 4 synthesis. Measured results indicate that the array can achieve a 13.8% bandwidth and a gain of more than 29.5 dBi. The first sidelobe level is -26.5 dB in the E-plane and -30.4 dB in the H-plane. The holistic sidelobe levels in both planes are better than -25 dB with a better than -40 dB cross-polarization.
Efficient Cache Update for In-Memory Cluster Computing with Spark

This paper proposes a scalable and efficient cacheupdate technique to improve the performance of in-memorycluster computing in Spark, a popular open-source system forbig data computing. Although the memory cache speeds up dataprocessing in Spark, its data immutability constraint requiresreloading the whole RDD when part of its data is updated. Suchconstraint makes the RDD update inefficient. To address thisproblem, we divide an RDD into partitions, and propose thepartial-update RDD (PRDD) method to enable users to replaceindividual partition(s) of an RDD. We devise two solutions to theRDD partition problem – a dynamic programming algorithm anda nonlinear programming method. Experiment results suggestthat, PRDD achieves 4.32x speedup when compared with theoriginal RDD in Spark. We apply PRDD to a billing system forChunghwa Telecomm, the largest telecommunication company inTaiwan. Our result shows that the PRDD based billing systemoutperforms the original billing system in CHT by a factor of24x in throughput. We also evaluate PRDD using the TPC-Hbenchmark, which also yields promising result.
Mobile Assisted Language Learning: Review of the Recent Applications of Emerging Mobile Technologies.

As mobile computing technologies have been more powerful and inclusive in people’s daily life, the issue of mobile assisted language learning (MALL) has also been widely explored in CALL research. Many researches on MALL consider the emerging mobile technologies have considerable potentials for the effective language learning. This review study focuses on the investigation of newly emerging mobile technologies and their pedagogical applications for language teachers and learners. Recent research or review on mobile assisted language learning tends to focus on more detailed applications of newly emerging mobile technology, rather than has given a broader point focusing on types of mobile device itself. In this paper, I thus reviewed recent research and conference papers for the last decade, which utilized newly emerging and integrated mobile technology. Its pedagogical benefits and challenges are discussed.
The factors associated with the burnout syndrome and fatigue in Cypriot nurses: a census report

Fatigue and burnout are two concepts often linked in the literature. However, regardless of their commonalities they should be approached as distinct concepts. The current and ever-growing reforms regarding the delivery of nursing care in Cyprus, stress for the development of ways to prevent burnout and effectively manage fatigue that can result from working in stressful clinical environments.



To explore the factors associated with the burnout syndrome in Cypriot nurses working in various clinical departments. A random sampling method taking into account geographical location, specialty and type of employment has been used.



A total of 1,482 nurses (80.4% were females) working both in the private and public sectors completed and returned an anonymous questionnaire that included several aspects related to burnout; the MBI scale, questions related to occupational stress, and questions pertaining to self reported fatigue. Two-thirds (65.1%) of the nurses believed that their job is stressful with the majority reporting their job as stressful being female nurses (67.7%). Twelve point eight percent of the nurses met Maslach's criteria for burnout. The prevalence of fatigue in nurses was found 91.9%. The prevalence of fatigue was higher in females (93%) than in males (87.5%) (p = 0.003). As opposed to the burnout prevalence, fatigue prevalence did not differ among the nursing departments (p = 0.166) and among nurses with a different marital status (p = 0.553). Burnout can be associated adequately knowing if nurses find their job stressful, their age, the level of emotional exhaustion and depersonalization. It has been shown that the fatigue may be thought of as a predictor of burnout, but its influence is already accounted by emotional exhaustion and depersonalization.



The clinical settings in Cyprus appear as stress generating environment for nurses. Nurses working both in the private and public sector appear to experience low to severe burnout. Self-reported fatigue interferes to the onset of emotional exhaustion and depersonalization.
Vision-Guided Aerial Manipulation Using a Multirotor With a Robotic Arm

This paper presents a vision guidance approach using an image-based visual servo (IBVS) for an aerial manipulator combining a multirotor with a multidegree of freedom robotic arm. To take into account the dynamic characteristics of the combined manipulation platform, the kinematic and dynamic models of the combined system are derived. Based on the combined model, a passivity-based adaptive controller which can be applied on both position and velocity control is designed. The position control is utilized for waypoint tracking such as taking off and landing, and the velocity control is engaged when the platform is guided by visual information. In addition, a guidance law utilizing IBVS is employed with modifications. To secure the view of an object with an eye-in-hand camera, IBVS is utilized with images taken from a fisheye camera. Also, to compensate underactuation of the multirotor, an image adjustment method is developed. With the proposed control and guidance laws, autonomous flight experiments involving grabbing and transporting an object are carried out. Successful experimental results demonstrate that the proposed approaches can be applied in various types of manipulation missions.
Conformal Asymmetric Meandered Flare (AMF) Antenna for Body-Worn Applications

A conformal body-worn antenna is presented for communications at 300 MHz. The antenna consists of a thin broadband flared-dipole element printed on a thin (0.1 mm) FR4 substrate without metallic backing or other shielding. The letter presents the design approach for tuning, matching, and mounting the antenna on the human body. Measurements are given for a human body phantom, and these are compared to simulations. Different antenna positions for improved coverage are also presented.
SIFT-ME: A New Feature for Human Activity Recognition

Action representation for robust human activity recognition is still a challenging problem. This thesis proposed a new feature for human activity recognition named SIFTMotion Estimation (SIFT-ME). SIFT-ME is derived from SIFT correspondences in a sequence of video frames and adds tracking information to describe human body motion. This feature is an extension of SIFT and is used to represent both translation and rotation in plane rotation for the key features. Compare with other features, SIFT-ME is new as it uses rotation of key features to describe action and it robust to the environment changes. Because SIFT-ME is derived from SIFT correspondences, it is invariant to noise, illumination, and small view angle change. It is also invariant to horizontal motion direction due to the embedded tracking information. For action recognition, we use Gaussian Mixture Model to learn motion patterns of several human actions (e.g., walking, running, turning, etc) described by SIFT-ME features. Then, we utilize the maximum log-likelihood criterion to classify actions. As a result, an average recognition rate of 96.6% was achieved using a dataset of 261 videos comprised of six actions performed by seven subjects. Multiple comparisons with existing implementations including optical flow, 2D SIFT and 3D SIFT were performed. The SIFT-ME approach outperforms the other approaches which demonstrate that SIFT-ME is a robust method for human activity recognition.