nils-herrmann/clean_scirepeval huggingface dataset:
Deception and Manipulation: The Arms of Leishmania, a Successful Parasite

Leishmania spp. are intracellular parasitic protozoa responsible for a group of neglected tropical diseases, endemic in 98 countries around the world, called leishmaniasis. These parasites have a complex digenetic life cycle requiring a susceptible vertebrate host and a permissive insect vector, which allow their transmission. The clinical manifestations associated with leishmaniasis depend on complex interactions between the parasite and the host immune system. Consequently, leishmaniasis can be manifested as a self-healing cutaneous affliction or a visceral pathology, being the last one fatal in 85-90% of untreated cases. As a result of a long host-parasite co-evolutionary process, Leishmania spp. developed different immunomodulatory strategies that are essential for the establishment of infection. Only through deception and manipulation of the immune system, Leishmania spp. can complete its life cycle and survive. The understanding of the mechanisms associated with immune evasion and disease progression is essential for the development of novel therapies and vaccine approaches. Here, we revise how the parasite manipulates cell death and immune responses to survive and thrive in the shadow of the immune system.
On the effectiveness of anonymizing networks for web search privacy

Web search has emerged as one of the most important applications on the internet, with several search engines available to the users. There is a common practice among these search engines to log and analyse the user queries, which leads to serious privacy implications. One well known solution to search privacy involves issuing the queries via an anonymizing network, such as Tor, thereby hiding one's identity from the search engine. A fundamental problem with this solution, however, is that user queries are still obviously revealed to the search engine, although they are "mixed" among the queries issued by other users of the same anonymization service.
 In this paper, we consider the problem of identifying the queries of a user of interest (UOI) within a pool of queries received by a search engine over an anonymizing network. We demonstrate that an adversarial search engine can extract the UOI's queries, when it is equipped with only a short-term user search query history, by utilizing only the query content information and off-the-shelf machine learning classifiers. More specifically, by treating a selected set of 60 users --- from the publicly-available AOL search logs --- as the users of interest performing web search over an anonymizing network, we show that each user's queries can be identified with 25.95% average accuracy, when mixed with queries of 99 other users of the anonymization service. This average accuracy drops to 18.95% when queries of 999 other users of the anonymization service are mixed together. Though the average accuracies are not so high, our results indicate that few users of interest could be identified with accuracies as high as 80--98%, even when their queries are mixed among queries of 999 other users. Our results cast serious doubts on the effectiveness of anonymizing web search queries by means of anonymizing networks.
Sleep-disordered breathing in heart failure.

Sleep-disordered breathing-comprising obstructive sleep apnoea (OSA), central sleep apnoea (CSA), or a combination of the two-is found in over half of heart failure (HF) patients and may have harmful effects on cardiac function, with swings in intrathoracic pressure (and therefore preload and afterload), blood pressure, sympathetic activity, and repetitive hypoxaemia. It is associated with reduced health-related quality of life, higher healthcare utilization, and a poor prognosis. Whilst continuous positive airway pressure (CPAP) is the treatment of choice for patients with daytime sleepiness due to OSA, the optimal management of CSA remains uncertain. There is much circumstantial evidence that the treatment of OSA in HF patients with CPAP can improve symptoms, cardiac function, biomarkers of cardiovascular disease, and quality of life, but the quality of evidence for an improvement in mortality is weak. For systolic HF patients with CSA, the CANPAP trial did not demonstrate an overall survival or hospitalization advantage for CPAP. A minute ventilation-targeted positive airway therapy, adaptive servoventilation (ASV), can control CSA and improves several surrogate markers of cardiovascular outcome, but in the recently published SERVE-HF randomized trial, ASV was associated with significantly increased mortality and no improvement in HF hospitalization or quality of life. Further research is needed to clarify the therapeutic rationale for the treatment of CSA in HF. Cardiologists should have a high index of suspicion for sleep-disordered breathing in those with HF, and work closely with sleep physicians to optimize patient management.
On Data Quality Assurance and Conflation Entanglement in Crowdsourcing for Environmental Studies

Volunteer geographical information (VGI), either in the context of citizen science or the mining of social media, has proven to be useful in various domains including natural hazards, health status, disease epidemics, and biological monitoring. Nonetheless, the variable or unknown data quality due to crowdsourcing settings are still an obstacle for fully integrating these data sources in environmental studies and potentially in policy making. The data curation process, in which a quality assurance (QA) is needed, is often driven by the direct usability of the data collected within a data conflation process or data fusion (DCDF), combining the crowdsourced data into one view, using potentially other data sources as well. Looking at current practices in VGI data quality and using two examples, namely land cover validation and inundation extent estimation, this paper discusses the close links between QA and DCDF. It aims to help in deciding whether a disentanglement can be possible, whether beneficial or not, in understanding the data curation process with respect to its methodology for future usage of crowdsourced data. Analysing situations throughout the data curation process where and when entanglement between QA and DCDF occur, the paper explores the various facets of VGI data capture, as well as data quality assessment and purposes. Far from rejecting the usability ISO quality criterion, the paper advocates for a decoupling of the QA process and the DCDF step as much as possible while still integrating them within an approach analogous to a Bayesian paradigm.
The meaningful identity: A longitudinal look at the interplay between identity and meaning in life in adolescence.

Identity formation in adolescence is closely linked to searching for and acquiring meaning in one's life. To date little is known about the manner in which these 2 constructs may be related in this developmental stage. In order to shed more light on their longitudinal links, we conducted a 3-wave longitudinal study, investigating how identity processes and meaning in life dimensions are interconnected across time, testing the moderating effects of gender and age. Participants were 1,062 adolescents (59.4% female), who filled in measures of identity and meaning in life at 3 measurement waves during 1 school year. Cross-lagged models highlighted positive reciprocal associations between (a) commitment processes and presence of meaning and (b) exploration processes and search for meaning. These results were not moderated by adolescents' gender or age. Strong identification with present commitments and reduced ruminative exploration helped adolescents in having a clear sense of meaning in their lives. We also highlighted the dual nature of search for meaning. This dimension was sustained by exploration in breadth and ruminative exploration, and it positively predicted all exploration processes. We clarified the potential for a strong sense of meaning to support identity commitments and that the process of seeking life meaning sustains identity exploration across time.
Transversus abdominis plane block vs. wound infiltration in Caesarean section: a randomised controlled trial.

Multiple studies suggest that transversus abdominis plane (TAP) block (without intrathecal morphine) after Caesarean section (CS) reduces post-operative morphine consumption. In our study, we wanted to compare the analgesic effect of TAP block with infiltration of the wound after CS.



We included 60 pregnant women scheduled for elective CS under spinal anaesthesia in a randomised, single-centre, double-blind study. Thirty patients received ultrasound-guided TAP block using 20 ml bupivacaine 0.25% with adrenaline 5 μg/ml bilaterally and 20 ml normal saline as wound infiltration (TAP group). The other 30 patients (the control group) received normal saline 20 ml bilaterally in the TAP, and 20 ml bupivacaine 0.25% with adrenaline 5 μg/ml as wound infiltration. The main outcome was cumulative morphine consumption at 48 h after surgery. In addition, continuous morphine consumption, pain scores and side effects were registered.



Fifty-seven patients completed the study. Cumulative morphine consumption at 48 h (mean±standard deviation) was 41±34 mg in the TAP group and 38±27 mg in the control group (P=0.7); a difference of 3 mg (95% confidence interval -13 to 19 mg). Morphine consumption at any time up to 48 h was virtually identical in both groups. Side effects were similar, except for a higher degree of sedation in the TAP group (P=0.04).



Compared with wound infiltration with local anaesthetics, TAP block did not reduce cumulative morphine consumption following CS. The TAP block was associated with more pronounced sedation.
Convergent innovation for sustainable economic growth and affordable universal health care: innovating the way we innovate.

This paper introduces convergent innovation (CI) as a form of meta-innovation-an innovation in the way we innovate. CI integrates human and economic development outcomes, through behavioral and ecosystem transformation at scale, for sustainable prosperity and affordable universal health care within a whole-of-society paradigm. To this end, CI combines technological and social innovation (including organizational, social process, financial, and institutional), with a special focus on the most underserved populations. CI takes a modular approach that convenes around roadmaps for real world change-a portfolio of loosely coupled complementary partners from the business community, civil society, and the public sector. Roadmaps serve as collaborative platforms for focused, achievable, and time-bound projects to provide scalable, sustainable, and resilient solutions to complex challenges, with benefits both to participating partners and to society. In this paper, we first briefly review the literature on technological innovation that sets the foundations of CI and motivates its feasibility. We then describe CI, its building blocks, and enabling conditions for deployment and scaling up, illustrating its operational forms through examples of existing CI-sensitive innovation.
A model for improved association of radar and camera objects in an indoor environment

This paper presents a model for the deviation of distances measured by radar and by optical sensors (3D point clouds). The measured 3D point clouds are typically clustered to objects and the cluster centers are then associated with the radar targets. However, the physical extent and the object geometry cause a divergence of the measured radar range from the cluster centers of the 3D point cloud. Existing solutions either ignore this deviation and compare radar ranges and cluster centers directly without any correction or use object class specific models for the correction. On the contrary, the presented parametric model is independent of the object class. All necessary properties (i.e. object size, flatness and aspect angle) can be obtained online from the covariance matrix of the 3D-point cloud. The model weights are fitted offline using a representative dataset of indoor objects with known radar and cluster correspondences. Furthermore, it is described how this model can be used to localize radar reflections in thermal infrared (TIR) images for a firefighting application. In this particular application, structure-from-motion (SfM) is used to obtain the 3D point cloud from a single moving camera. Experiments with measured data show that the proposed model allows a better data association compared to a direct association.
Prenatal US diagnosis of congenital imperforate hymen

A 32-year-old woman, gravida 1, para 0, was referred for third-trimester sonography at 34 weeks’ gestation to evaluate fetal growth. Sonography revealed a female fetus with an echogenic, midline, nonvascular pelvic mass  and no associated genitourinary abnormality. Differential diagnoses included an ovarian mass, distended rectum, hydrocolpos, vaginal atresia and urogenital sinus. Postnatal US revealed an echogenic, fluid-containing midline pelvic mass  in the setting of an imperforate hymen. The cervix is marked (double white arrows).
Likelihood ratio for trisomy 21 in fetuses with absent nasal bone at the 11-14-week scan.

To update the likelihood ratio for trisomy 21 in fetuses with absent nasal bone at the 11-14-week scan.



Ultrasound examination of the fetal profile was carried out and the presence or absence of the nasal bone was noted immediately before karyotyping in 5918 fetuses at 11 to 13+6 weeks. Logistic regression analysis was used to examine the effect of maternal ethnic origin and fetal crown-rump length (CRL) and nuchal translucency (NT) on the incidence of absent nasal bone in the chromosomally normal and trisomy 21 fetuses.



The fetal profile was successfully examined in 5851 (98.9%) cases. In 5223/5851 cases the fetal karyotype was normal and in 628 cases it was abnormal. In the chromosomally normal group the incidence of absent nasal bone was related first to the ethnic origin of the mother, being 2.2% for Caucasians, 9.0% for Afro-Caribbeans and 5.0% for Asians; second to fetal CRL, being 4.7% for CRL of 45-54 mm, 3.4% for CRL of 55-64 mm, 1.4% for CRL of 65-74 mm and 1% for CRL of 75-84 mm; and third to NT, being 1.6% for NT < or = 95th centile, 2.7% for NT > 95th centile-3.4 mm, 5.4% for NT 3.5-4.4 mm, 6% for NT 4.5-5.4 mm and 15% for NT > or = 5.5 mm. In the chromosomally abnormal group there was absent nasal bone in 229/333 (68.8%) cases with trisomy 21 and in 95/295 (32.2%) cases with other chromosomal defects. Logistic regression analysis demonstrated that in the chromosomally normal fetuses significant independent prediction of the likelihood of absent nasal bone was provided by CRL, NT and Afro-Caribbean ethnic group, and in the trisomy 21 fetuses by CRL and NT. The likelihood ratio for trisomy 21 for absent nasal bone was derived by dividing the likelihood in trisomy 21 by that in normal fetuses.



At the 11-14-week scan the incidence of absent nasal bone is related to the presence or absence of chromosomal defects, CRL, NT and ethnic origin.
A Real-Time Sliding Mode Control for a Wind Energy System Based on a Doubly Fed Induction Generator

In this paper, a real time sliding mode control scheme for a variable speed wind turbine that incorporates a doubly feed induction generator is described. In this design, the so-called vector control theory is applied, in order to simplify the system electrical equations. The proposed control scheme involves a low computational cost and therefore can be implemented in real-time applications using a low cost Digital Signal Processor (DSP). The stability analysis of the proposed sliding mode controller under disturbances and parameter uncertainties is provided using the Lyapunov stability theory. A new experimental platform has been designed and constructed in order to analyze the real-time performance of the proposed controller in a real system. Finally, the experimental validation carried out in the experimental platform shows; on the one hand that the proposed controller provides high-performance dynamic characteristics, and on the other hand that this scheme is robust with respect to the uncertainties that usually appear in the real systems.
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Expanding view of minimal invasive surgery horizon reveals new practice areas for surgeons and patients. Laparoscopic inguinal hernia repair is an example in progress wondered by many patients and surgeons. Advantages in laparoscopic repair motivate surgeons to discover this popular field. In addition, patients search the most convenient surgical method for themselves today. Laparoscopic approaches to inguinal hernia surgery have become popular as a result of the development of experience about different laparoscopic interventions, and these techniques are increasingly used these days. As other laparoscopic surgical methods, experience is the most important point in order to obtain good results. This chapter aims to show technical details, pitfalls and the literature results about two methods that are commonly used in laparoscopic inguinal hernia repair.
Medication augmentation after the failure of SSRIs for depression.

Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach.



We randomly assigned 565 adult outpatients who had nonpsychotic major depressive disorder without remission despite a mean of 11.9 weeks of citalopram therapy (mean final dose, 55 mg per day) to receive sustained-release bupropion (at a dose of up to 400 mg per day) as augmentation and 286 to receive buspirone (at a dose of up to 60 mg per day) as augmentation. The primary outcome of remission of symptoms was defined as a score of 7 or less on the 17-item Hamilton Rating Scale for Depression (HRSD-17) at the end of this study; scores were obtained over the telephone by raters blinded to treatment assignment. The 16-item Quick Inventory of Depressive Symptomatology--Self-Report (QIDS-SR-16) was used to determine the secondary outcomes of remission (defined as a score of less than 6 at the end of this study) and response (a reduction in baseline scores of 50 percent or more).



The sustained-release bupropion group and the buspirone group had similar rates of HRSD-17 remission (29.7 percent and 30.1 percent, respectively), QIDS-SR-16 remission (39.0 percent and 32.9 percent), and QIDS-SR-16 response (31.8 percent and 26.9 percent). Sustained-release bupropion, however, was associated with a greater reduction (from baseline to the end of this study) in QIDS-SR-16 scores than was buspirone (25.3 percent vs. 17.1 percent, P<0.04), a lower QIDS-SR-16 score at the end of this study (8.0 vs. 9.1, P<0.02), and a lower dropout rate due to intolerance (12.5 percent vs. 20.6 percent, P<0.009).



Augmentation of citalopram with either sustained-release bupropion or buspirone appears to be useful in actual clinical settings. Augmentation with sustained-release bupropion does have certain advantages, including a greater reduction in the number and severity of symptoms and fewer side effects and adverse events.
Design Considerations for Single-Mode Microring Lasers Using Parity–Time Symmetry

Coupled microring arrangements with balanced gain and loss, also known as parity-time symmetric systems, are investigated both analytically and experimentally. In these configurations, stable single-mode lasing can be achieved at pump powers well above threshold. This self-adaptive mode management technique is broadband and robust to small fabrication imperfections. The results presented in this paper provide a new avenue in designing mode-selective chip-scale in-plane semiconductor lasers by utilizing the complex dynamics of coupled gain/loss cavities.
In Vitro Flowering Induction in Date Palm (Phoenix dactylifera L.)

This article reports on a histological and morphological study on the induction of in vitro flowering in vegetatively propagated plantlets from different date palm cultivars. The study aimed to further explore the control of in vitro flower induction in relation to the photoperiodic requirements in date palm and to come up with a novel system that may allow for early sex determination through plant cycle reduction. In fact, the in vitro reversion of a shoot meristem from a vegetative to a reproductive state was achieved within 1–5 months depending on the variety considered. This reversion was accompanied by several morphological transformations that affected the apical part of the leafy bud corresponding mainly to a size increase of the prefloral meristem zone followed by the appearance of an inflorescence. The flowers that were produced in vitro were histologically and morphologically similar to those formed in vivo. The histological examination of the in vitro flowering induction process showed that the conversion into inflorescences involved the entire apical vegetative meristem of the plantlet used as a starting material and brought about a change in its anatomical structure without affecting its phyllotaxis and the leaf shape. Through alternating between hormone-free and hormone-containing media under different light/dark conditions, the highest flower induction rates were obtained with a basal Murashige and Skoog medium. A change in the architectural model of date palm was induced because unlike the natural lateral flowering, in vitro flowering was terminal. Such in vitro flower induction allowed a significant reduction in plant cycle and can, therefore, be considered a promising candidate to save time for future improvement and selection programs in date palm.
Text-to-video: a semantic search engine for internet videos

Semantic search or text-to-video search in video is a novel and challenging problem in information and multimedia retrieval. Existing solutions are mainly limited to text-to-text matching, in which the query words are matched against the user-generated metadata. This kind of text-to-text search, though simple, is of limited functionality as it provides no understanding about the video content. This paper presents a state-of-the-art system for event search without any user-generated metadata or example videos, known as text-to-video search. The system relies on substantial video content understanding and allows for searching complex events over a large collection of videos. The proposed text-to-video search can be used to augment the existing text-to-text search for video. The novelty and practicality are demonstrated by the evaluation in NIST TRECVID 2014, where the proposed system achieves the best performance. We share our observations and lessons in building such a state-of-the-art system, which may be instrumental in guiding the design of the future system for video search and analysis.
Improving Efficiency of Autonomous Vehicles by V2V Communication

Autonomous vehicles are widely regarded as a promising technology to improve the safety of transportation systems. However, the efficiency of vehicles may be compromised to ensure safety when there are large uncertainties in perception and prediction of the behaviors of other road participants due to limitations in sensors. To remedy this problem, vehicle to vehicle (V2V) communication is applied to improve efficiency of autonomous vehicles during interactions with other vehicles. By requiring the vehicles to communicate their intentions with one another, the efficiency of the vehicles can be improved in terms of smaller variations in their speed profiles and smaller delay as demonstrated in the simulations.