nils-herrmann/clean_scirepeval huggingface dataset:
Ground reaction force and kinematic analysis of limb loading on two different beach sand tracks in harness trotters.

Although beach training is commonly used in horses, limb loading on beach sand has never been investigated. A dynamometric horseshoe (DHS) is well adapted for this purpose.



To compare ground reaction force (GRF) and fetlock kinematics measured in harness trotters on 2 tracks of beach sand with different water content.



Two linear sand tracks were compared: firm wet sand (FWS, 19% moisture) vs. deep wet sand (DWS, 13.5% moisture). Four French trotters (550 ± 22 kg) were used. Their right forelimb was equipped with a DHS and skin markers. Each track was tested 3 times at 7 m/s. Each trial was filmed by a high-speed camera (600 Hz); DHS and speed data acquisition was performed at 10 kHz on 10 consecutive strides. All recordings were synchronised. The components Fx (parallel to the hoof solar surface) and Fz (perpendicular) of the GRF were considered. For 3 horses the fetlock angle and forelimb axis-track angle at landing were measured. Statistical differences were tested using the GLM procedure (SAS; P < 0.05).



Stance duration was increased on DWS compared to FWS. Fzmax and Fxmax (oriented, respectively, downwards and forwards relatively to the solar surface) and the corresponding loading rates, were decreased on DWS and these force peaks occurred later. Fxmin (backwards) was not significantly different between both surfaces; the propulsive phase (Fx negative) was longer and the corresponding impulse higher, on DWS compared to FWS. The forelimb was more oblique to the track at landing and maximal fetlock extension was less and delayed on DWS.



This study confirms that trotting on deep sand overall reduces maximal GRF and induces a more progressive limb loading. However, it increases the propulsive effort and likely superficial digital flexor tendon tension at the end of stance, which should be taken into account in beach training.
Quantized Dynamic Time Warping (DTW) algorithm

DTW algorithm compares the parameters of an unknown spoken word with the parameters of one or more reference templates. The more reference templates are used for the same word, the higher is the recognition rate. But increasing the number of reference templates for the same word to recognize, leads to an increase in memory resources and computing time. The proposed algorithm is used in the learning phase and combines the advantages of DTW and Vector Quantization (VQ); instead of storing multiple reference templates, it stores only one reference model for each word and that reference is based on classes (like in the vector quantization method), each class is represented by a centroid (or codeword). In the recognition phase, the parameters of the unknown utterance are compared to the centroids of the reference model. This solution increases the speed of calculation in the recognition phase and reduces the quantity of used memory.
Emergency management of pediatric burns.

Burn-related injuries are a leading cause of morbidity and mortality in children. Burn injuries rank third among injury-related deaths in children aged 1 to 9 years. In 2001, there were more than 181,000 fireand burn-related injuries, more than 4200 hospitalizations, and 672 deaths in children aged 0 to 19 years in the United States. Pediatric patients and the elderly have the highest morbidity and mortality associated with burn injuries. A majority of these children are initially seen in emergency departments (EDs) around the country; therefore, it is necessary that all emergency professionals are proficient in burn management in the pediatric population. Many burns are the result of unintentional events, and others are the result of nonaccidental trauma. However, most burns are preventable. As a primary care provider in the ED, it is necessary to have the knowledge and skills not only to treat burns, but to also counsel families regarding burn prevention and to identify burns resulting from child abuse.
Ultrasound Examination of the Fetal Heart.

Congenital heart disease (CHD) occurs in 4-13 per 1000 births in the United States. While many risk factors for CHD have been identified, more than 90% of cases occur in low-risk patients. Guidelines for fetal cardiac screening during the second trimester anatomy ultrasound have been developed by the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) in order to improve antenatal detection rates and to standardize the fetal cardiac screening examination. Patients found to be at increased risk of CHD because of risk factors or an abnormal screening examination should be referred for second trimester fetal echocardiography. Recently, 3D and 4D ultrasound techniques are being utilized to enhance detection rates and to better characterize cardiac lesions, and several first trimester ultrasound screening markers have been proposed to identify patients at increased risk of CHD. However, detection rates have not improved significantly due to limitations such as cost, access, and training that are associated with new technologies and screening methods. The most cost effective way to improve detection rates of CHD may be to standardize screening protocols across practices according to established guidelines and to have a low threshold for referral for fetal echocardiography.
Entertainment capture through heart rate activity in physical interactive playgrounds

An approach for capturing and modeling individual entertainment (“fun”) preferences is applied to users of the innovative Playware playground, an interactive physical playground inspired by computer games, in this study. The goal is to construct, using representative statistics computed from children’s physiological signals, an estimator of the degree to which games provided by the playground engage the players. For this purpose children’s heart rate (HR) signals, and their expressed preferences of how much “fun” particular game variants are, are obtained from experiments using games implemented on the Playware playground. A comprehensive statistical analysis shows that children’s reported entertainment preferences correlate well with specific features of the HR signal. Neuro-evolution techniques combined with feature set selection methods permit the construction of user models that predict reported entertainment preferences given HR features. These models are expressed as artificial neural networks and are demonstrated and evaluated on two Playware games and two control tasks requiring physical activity. The best network is able to correctly match expressed preferences in 64% of cases on previously unseen data (p−value 6 · 10−5). The generality of the methodology, its limitations, its usability as a real-time feedback mechanism for entertainment augmentation and as a validation tool are discussed.
Building a RCP (Rate Control Protocol) Test Network

We recently proposed the Rate Control Protocol (RCP) as way to minimize download times (or flow-completion times). Simulations suggest that if RCP were widely deployed, downloads would frequently finish ten times faster than with TCP. This is because RCP involves explicit feedback from the routers along the path, allowing a sender to pick a fast starting rate, and adapt quickly to network conditions. RCP is particularly appealing because it can be shown to be stable under broad operating conditions, and its performance is independent of the flow-size distribution and the RTT. Although it requires changes to the routers, the changes are small: The routers keep no per-flow state or per-flow queues, and the per-packet processing is minimal. However, the bar is high for a new congestion control mechanism - introducing a new scheme requires enormous change, and the argument needs to be compelling. And so, to enable some scientific and repeatable experiments with RCP, we have built and tested an open and public implementation of RCP; we have made available both the end- host software, and the router hardware. In this paper we describe our end-host implementation of RCP in Linux, and our router implementation in Verilog (on the NetFPGA platform). We hope that others will be able to use these implementations to experiment with RCP and further our understanding of congestion control.
Asthma-predictive-index, bronchial-challenge, sputum eosinophils in acutely wheezing preschoolers.

Most preschoolers with viral wheezing exacerbations are not atopic.



To test in a prospective controlled trial whether wheezing preschoolers presenting to the ED are different from the above in three different domains defining asthma: the atopic characteristics based on stringent asthma predictive index (S-API), the characteristics of bronchial hyper-responsiveness (BHR), and airway inflammation.



The S-API was prospectively collected in 41 preschoolers (age 31.9 ± 17.4 months, range; 1-6 years) presenting to the ED with acute wheezing and compared to healthy preschoolers (n = 109) from our community (community control group). Thirty out of the 41 recruited preschoolers performed two sets of bronchial challenge tests (BCT)-(methacholine and adenosine) within 3 weeks and following 3 months of the acute event and compared to 30 consecutive ambulatory preschoolers, who performed BCT for diagnostic workup in our laboratory (ambulatory control group). On presentation, induced sputum (IS) was obtained from 22 of the 41 children.



Primary: S-API, secondary: BCTs characteristics and percent eosinophils in IS.



Significantly more wheezing preschoolers were S-API positive compared with the community control group: 20/41 (48.7%) versus 15/109 (13.7%, P < 0.001). All methacholine-BCTs-30/30 (100%) were positive compared with 13/14 (92.8%) in the ambulatory control group (P = 0.32). However, 23/27 (85.2%) were adenosine-BCT positive versus 3/17 (17.5%) in the ambulatory control group (P < 0.001). Diagnostic IS success rate was 18/22 (81.8%). Unexpectedly, 9/18 (50.0%) showed eosinophilia in the IS.



Wheezing preschoolers presenting to the ED is a unique population with significantly higher rate of positive S-API and adenosine-BCT compared with controls and frequently (50%) express eosinophilic airway inflammation.
TG13: Updated Tokyo Guidelines for the management of acute cholangitis and cholecystitis.

In 2007, the Tokyo Guidelines for the management of acute cholangitis and cholecystitis (TG07) were first published in the Journal of Hepato-Biliary-Pancreatic Surgery. The fundamental policy of TG07 was to achieve the objectives of TG07 through the development of consensus among specialists in this field throughout the world. Considering such a situation, validation and feedback from the clinicians' viewpoints were indispensable. What had been pointed out from clinical practice was the low diagnostic sensitivity of TG07 for acute cholangitis and the presence of divergence between severity assessment and clinical judgment for acute cholangitis. In June 2010, we set up the Tokyo Guidelines Revision Committee for the revision of TG07 (TGRC) and started the validation of TG07. We also set up new diagnostic criteria and severity assessment criteria by retrospectively analyzing cases of acute cholangitis and cholecystitis, including cases of non-inflammatory biliary disease, collected from multiple institutions. TGRC held meetings a total of 35 times as well as international email exchanges with co-authors abroad. On June 9 and September 6, 2011, and on April 11, 2012, we held three International Meetings for the Clinical Assessment and Revision of Tokyo Guidelines. Through these meetings, the final draft of the updated Tokyo Guidelines (TG13) was prepared on the basis of the evidence from retrospective multi-center analyses. To be specific, discussion took place involving the revised new diagnostic criteria, and the new severity assessment criteria, new flowcharts of the management of acute cholangitis and cholecystitis, recommended medical care for which new evidence had been added, new recommendations for gallbladder drainage and antimicrobial therapy, and the role of surgical intervention. Management bundles for acute cholangitis and cholecystitis were introduced for effective dissemination with the level of evidence and the grade of recommendations. GRADE systems were utilized to provide the level of evidence and the grade of recommendations. TG13 improved the diagnostic sensitivity for acute cholangitis and cholecystitis, and presented criteria with extremely low false positive rates adapted for clinical practice. Furthermore, severity assessment criteria adapted for clinical use, flowcharts, and many new diagnostic and therapeutic modalities were presented. The bundles for the management of acute cholangitis and cholecystitis are presented in a separate section in TG13. Free full-text articles and a mobile application of TG13 are available via http://www.jshbps.jp/en/guideline/tg13.html.
Response Ranking with Deep Matching Networks and External Knowledge in Information-seeking Conversation Systems

Intelligent personal assistant systems with either text-based or voice-based conversational interfaces are becoming increasingly popular around the world. Retrieval-based conversation models have the advantages of returning fluent and informative responses. Most existing studies in this area are on open domain ''chit-chat'' conversations or task / transaction oriented conversations. More research is needed for information-seeking conversations. There is also a lack of modeling external knowledge beyond the dialog utterances among current conversational models. In this paper, we propose a learning framework on the top of deep neural matching networks that leverages external knowledge for response ranking in information-seeking conversation systems. We incorporate external knowledge into deep neural models with pseudo-relevance feedback and QA correspondence knowledge distillation. Extensive experiments with three information-seeking conversation data sets including both open benchmarks and commercial data show that, our methods outperform various baseline methods including several deep text matching models and the state-of-the-art method on response selection in multi-turn conversations. We also perform analysis over different response types, model variations and ranking examples. Our models and research findings provide new insights on how to utilize external knowledge with deep neural models for response selection and have implications for the design of the next generation of information-seeking conversation systems.
Pseudo-LiDAR from Visual Depth Estimation: Bridging the Gap in 3D Object Detection for Autonomous Driving

3D object detection is an essential task in autonomous driving. Recent techniques excel with highly accurate detection rates, provided the 3D input data is obtained from precise but expensive LiDAR technology. Approaches based on cheaper monocular or stereo imagery data have, until now, resulted in drastically lower accuracies — a gap that is commonly attributed to poor image-based depth estimation. However, in this paper we argue that data representation (rather than its quality) accounts for the majority of the difference. Taking the inner workings of convolutional neural networks into consideration, we propose to convert imagebased depth maps to pseudo-LiDAR representations — essentially mimicking LiDAR signal. With this representation we can apply different existing LiDAR-based detection algorithms. On the popular KITTI benchmark, our approach achieves impressive improvements over the existing stateof-the-art in image-based performance — raising the detection accuracy of objects within 30m range from the previous state-of-the-art of 22% to an unprecedented 74%. At the time of submission our algorithm holds the highest entry on the KITTI 3D object detection leaderboard for stereo image based approaches.
Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis.

Nitric oxide (NO) mediates activation of satellite precursor cells to enter the cell cycle. This provides new precursor cells for skeletal muscle growth and muscle repair from injury or disease. Targeting a new drug that specifically delivers NO to muscle has the potential to promote normal function and treat neuromuscular disease, and would also help to avoid side effects of NO from other treatment modalities. In this research, we examined the effectiveness of the NO donor, iosorbide dinitrate (ISDN), and a muscle relaxant, methocarbamol, in promoting satellite cell activation assayed by muscle cell DNA synthesis in normal adult mice. The work led to the development of guaifenesin dinitrate (GDN) as a new NO donor for delivering nitric oxide to muscle. The results revealed that there was a strong increase in muscle satellite cell activation and proliferation, demonstrated by a significant 38% rise in DNA synthesis after a single transdermal treatment with the new compound for 24 h. Western blot and immunohistochemistry analyses showed that the markers of satellite cell myogenesis, expression of myf5, myogenin, and follistatin, were increased after 24 h oral administration of the compound in adult mice. This research extends our understanding of the outcomes of NO-based treatments aimed at promoting muscle regeneration in normal tissue. The potential use of such treatment for conditions such as muscle atrophy in disuse and aging, and for the promotion of muscle tissue repair as required after injury or in neuromuscular diseases such as muscular dystrophy, is highlighted.
‘Public service motivation’ as an argument for government provision

A public service motivation (PSM) inclines employees to provide effort out of concern for the impact of that effort on a valued social service. Though deemed to be important in the literature on public administration, this motivation has not been formally considered by economists. When a PSM exists, this paper establishes conditions under which government bureaucracy can better obtain PSM motivated effort from employees than a standard profit maximizing firm. The model also provides an efficiency rationale for low-powered incentives in both bureaucracies and other organizations producing social services.
Massively multiplayer online role-playing games (MMORPG): association between its addiction, self-control and mental disorders among young people in Vietnam.

To explore the association between MMORPG addiction and mental health status, and between self-control ability and mental health status among young male MMORPG players in Hanoi, Vietnam.



In this cross-sectional study, 10 computer game rooms were randomly selected out of 77 in five communes in Hanoi. From these game rooms, 350 MMORPG players were purposively recruited as a study group, of whom 344 completed the questionnaire. In the same five communes, 344 non-players were selected as a control group. An online game addiction scale, a self-control scale and the Vietnamese SRQ-20 were used to measure the degree of MMORPG addiction, self-control ability and level of mental disorders.



MMORPG players had significantly higher mental disorders scale scores than non-players (p < .001). The strongest positive correlation was detected between MMORPG addiction scale scores and mental disorders scale scores (r = 0.730, p < .001). Self-control scale scores were negatively associated with mental disorders scale scores (r = -0.345, p < .001). The average amount of money spent on games per month, MMORPG addiction scale score and self-control scale score were considered the best predictors of a higher mental disorders scale score.



Young, male MMORPG players with higher addiction scores were more likely to have higher mental disorders scale scores, and such mental status was negatively associated with the level of self-control in Hanoi, Vietnam. Closer attention should be paid to prevent mental disorders among MMORPG players.
Managing human error in aviation.

Crew resource management (CRM) programs were developed to address team and leadership aspects of piloting modern airplanes. The goal is to reduce errors through team work. Human factors research and social, cognitive, and organizational psychology are used to develop programs tailored for individual airlines. Flight crews study accident case histories, group dynamics, and human error. Simulators provide pilots with the opportunity to solve complex flight problems. CRM in the simulator is called line-oriented flight training (LOFT). In automated cockpits CRM promotes the idea of automation as a crew member. Cultural aspects of aviation include professional, business, and national culture. The aviation CRM model has been adapted for training surgeons and operating room staff in human factors.
ANCA-associated vasculitides—advances in pathogenesis and treatment

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) include Wegener granulomatosis, microscopic polyangiitis, Churg–Strauss syndrome and renal-limited vasculitis. This Review highlights the progress that has been made in our understanding of AAV pathogenesis and discusses new developments in the treatment of these diseases. Evidence from clinical studies, and both in vitro and in vivo experiments, supports a pathogenic role for ANCAs in the development of AAV; evidence is stronger for myeloperoxidase-ANCAs than for proteinase-3-ANCAs. Neutrophils, complement and effector T cells are also involved in AAV pathogenesis. With respect to treatment of AAV, glucocorticoids, cyclophosphamide and other conventional therapies are commonly used to induce remission in generalized disease. Pulse intravenous cyclophosphamide is equivalent in efficacy to oral cyclophosphamide but seems to be associated with less adverse effects. Nevertheless, alternatives to cyclophosphamide therapy have been investigated, such as the use of methotrexate as a less-toxic alternative to cyclophosphamide to induce remission in non-organ-threatening or non-life-threatening AAV. Furthermore, rituximab is equally as effective as cyclophosphamide for induction of remission in AAV and might become the standard of therapy in the near future. Controlled trials in which specific immune effector cells and molecules are being therapeutically targeted have been initiated or are currently being planned.
Optimisation of kelp (Laminaria digitata) gametophyte growth and gametogenesis: effects of photoperiod and culture media

The kelp Laminaria digitata (Hudson) J.V. Lamouroux (Laminariales, Phaeophyceae) is currently cultivated on a small-scale in several north Atlantic countries, with much potential for expansion. The initial stages of kelp cultivation follow one of two methods: either maximising (gametophyte method) or minimising (direct method) the vegetative growth phase prior to gametogenesis. The gametophyte method is of increasing interest because of its utility in strain selection programmes. In spite of this, there are no studies of L. digitata gametophyte growth and reproductive capacity under commercially relevant conditions. Vegetative growth measured by length and biomass, and rate of gametogenesis, was examined in a series of experiments. A two-way fixed-effects model was used to examine the effects of both photoperiod (8:12; 12:12; 16:8, 24:0 L:D) and commonly used/commercially available growth media (f/2; Algoflash; Provasoli Enriched Seawater) on the aforementioned parameters. All media resulted in good performance of gametophytes under conditions favouring vegetative growth, while f/2 clearly resulted in better gametophyte performance and a faster rate of gametogenesis under conditions stimulating transition to fertility. Particularly, the extent of sporophyte production (% of gametophytes that produced sporophytes) at the end of the experiment showed clear differences between treatments in favour of f/2: f/2 = 30%; Algoflash = 9%; Provasoli Enriched Seawater = 2%. The effect of photoperiod was ambiguous, with evidence to suggest that the benefit of continuous illumination is less than expected. Confirmation of photoperiodic effect is necessary, using biomass as a measure of productivity and taking greater account of effects of genotypic variability.