nils-herrmann/clean_scirepeval huggingface dataset:
Use of the noninvasive entero-test in the detection of Helicobacter pylori in children in an endemic area in Colombia.

Gastric infection with Helicobacter pylori (H pylori), a strong risk factor for gastric cancer, is highly prevalent in children residing in the Colombian Andes. We aimed to validate the use of the Entero-test to culture and genotype H pylori strains from asymptomatic Colombian children.



Children (ages 10-15 years, n = 110, 80 of which were H pylori positive by the urea breath test [UBT]) were subjected to the Entero-test, and strings were cultured and/or used for DNA extraction for polymerase chain reaction (PCR). These children had been treated for H pylori in 2007. A second population of children (ages 10-15 years, n = 95),which had not been previously treated, was also subjected to the Entero-test.



Of UBT-positive children in the treated group, 29 of 80 (36%) Entero-test samples were H pylori culture positive; 29 additional string extracts were tested by PCR for the H pylori virulence factors cagA and vacA. PCR from cultures and extracts yielded a sensitivity of 74% and specificity of 87%. In the untreated group, 16 of 94 UBT-positive children (17%) produced Entero-tests that were culture positive. Fifty-eight of 94 (62%) string extracts were PCR positive for cagA and/or vacA. In previously treated children, H pylori strains were more often the less virulent vacA s2 (P = 0.001), m2 (P = 0.006), and i2 genotypes (P = 0.039).



The Entero-test may be used as a noninvasive test to detect H pylori in asymptomatic children residing in high-risk areas for gastric cancer. Treatment of H pylori in children was associated with less virulent genotypes.
Kernel Methods for Pattern Analysis

This inspiring book becomes one that is very booming. After published, this book can steal the market and book lovers to always run out of this book. And now, we will not let you run out any more to get this book. Why should be kernel methods for pattern analysis? As a book lover, you must know that enjoying the book to read should be relevant to how you exactly need now. If they are not too much relevance, you can take the way of the inspirations to create for new inspirations.
Effect of Warm-Supplementing Kidney Yang (WSKY) added to risperidone on quality of life in patients with schizophrenia: a randomized controlled trial.

To evaluate the quality of life, efficacy and safety of Warm-Supplementing Kidney Yang (WSKY) added to risperidone in patients with schizophrenia.



A randomized controlled trial.



The outpatient and inpatient departments of three hospitals.



One hundred and twenty patients with clinically diagnosed schizophrenia with predominantly negative symptoms were included in the study.



All 120 patients were randomly assigned to double-blind treatment with WSKY group (n = 60) or placebo group (n = 60) added to risperidone for eight weeks.



The efficacy measures included the World Health Organization Quality of Life Scale (WHOQOL-100), the Positive and Negative Syndrome Scale (PANSS), the Social Disability Screening Schedule and the Hamilton Rating Scale for Depression. Safety and tolerability were assessed throughout the trial.



The scores of quality of life in the WSKY group showed statistically significant improvement at the end-point of treatment compared with those in the placebo group (WSKY, increasing 40.5 (29.4); placebo, increasing 14.4 (27.1); F =24.900, P<0.001), while the scores of social function and depression symptoms also showed statistically significant improvement. The response rates for the WHOQOL-100 total scores were 50.0% for the WSKY group versus 31.7% for placebo group (chi( 2) = 4.172, P=0.041). There were no significant differences in the safety/tolerability measures between the WSKY group and the placebo group during treatment.



The results suggest that WSKY added to risperidone significantly improved the quality of life, social function, depression symptom compared with placebo added to risperidone.
Right ventricular systolic dysfunction in patients with severe ischemic cardiomyopathy - CMR insights into an interventricular relationship

Right ventricular systolic dysfunction is associated with worsened outcomes and poor survival in patients with heart failure. However, it is unclear what mechanisms, other than the presence of RV infarction, contribute to the development of RV dysfunction in patients with severe ischemic cardiomyopathy. We sought to determine the impact of baseline demographic variables, CAD severity, LV diastolic function assessed by echocardiography, ventriculovascular coupling, LV remodeling, aortic biomechanical properties, and RV infarction, assessed by CMR, on RV ejection fraction.
Parents and Teachers Make Different Contributions to a Shared Perspective on Hyperactive–Impulsive and Inattentive Symptoms: A Multivariate Analysis of Parent and Teacher Ratings on the Symptom Domains of ADHD

Attention deficit hyperactivity disorder (ADHD) is characterised by developmentally inappropriate and impairing levels of inattentive and hyperactive-impulsive behaviours. We aimed to investigate the differential effects of parent and teacher ratings on inattention and hyperactivity-impulsivity and the extent of genetic overlap between the two behavioural dimensions. Multivariate structural equation modelling was performed on DSM-IV based ADHD ratings by parents and teachers collected on a general population sample of 672 twin pairs, at ages 7-10 years. This study is the first to simultaneously use parent and teacher ratings in twin modelling to examine the effects of different raters on the two behavioural dimensions of ADHD. The findings indicated that hyperactivity-impulsivity and inattention load on to separate latent factors that represent a common behavioural view for both parents and teachers, although there are additional aspects to the observations of these behaviours that are unique to each type of rater. The findings further indicate some shared aetiology for hyperactivity-impulsivity and inattention as measured by both parent and teacher ratings, in agreement with previous findings on the aetiology of the two symptom dimensions of ADHD.
Correction: Pirfenidone for Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis

There are errors in the ninth and tenth sentences of the Abstract. These sentences should read: Also there was a decrease in the risk of progression (RR of PFS: 0.82 IC 0.73–0.92) compared to placebo.  We observed significant differences in physiologic and clinically relevant outcomes such as reduction in all-cause mortality, IPF related mortality, worsening of IPF and improvement of PFS. So pirfenidone treatment should be considered not only for its benefits in pulmonary function tests but also by its clinically relevant outcomes. There are multiple errors in the Results described below. The third and fourth sentences of the “Progression-free Survival (PFS)” section should read: The meta-analysis includes 786 patients in intervention group and 728 in placebo group . Pirfenidone decreased the risk of progression (RR of PFS: 0.82 IC 0.73–0.92, I2:22%) compared to placebo. We rated the quality of evidence as moderate, because of indirectness. The third sentence of the “Worsening of IPF” section should read: The meta-analysis includes 858 patients in intervention group and 763 in placebo group . Pirfenidone improves worsening of IPF with a RR of 0.64 (IC 0.50–0.83, I2:23%) compared to placebo. The second sentence of the “Adverse events” section should read: The meta-analysis includes 859 patients in intervention group and 763 in placebo group . There is an error in the third sentence of the fourth paragraph of the Discussion. It should read: We also observed differences in clinically relevant outcomes such as reduction in allcause mortality, IPF related mortality, worsening of IPF and risk of progression; but no benefit on acute exacerbation of IPF. There are errors in the fourth and fifth columns of Table 2. Please see the corrected Table 2 here. Fig 5 and its caption are incorrect.
Effects of aminophyllinein preventing renal failure in premature neonates with asphyxia in Isfahan-Iran.

Considering the relation between prematurity andasphyxia and also renal failure in neonates, the aim of this study was to determine the effect of aminophyllinein urine and serum indices of renal failure and consequently its prevention, in Premature Infants with asphyxia in Esfahan-lran.



In this descriptive clinical trial study, 22 preterm neonates diagnosed with perinatal asphyxia in neonatal ward of Shahid Beheshti hospital, during 2009.The participants were randomized in two intervention and placebo groups. They randomized to receive a single dose of aminophyiline (5 mg/kg) or placebo of 5% dextrose water for injection (5 cc/kg) during the first hour of life. Renal function was assessed by GFR, beta2-microglobulin (beta2M), N-acetyl-glucosaminidase (NAG) serum creatinine and electrolytes level measurement, during the 1st, 4th and 7th day of life, in two studied groups. The results compare between the two groups before and after intervention.



Mean of urine output, was significantly higher in neonates who received aminophylline (P < 0.05).Mean of 132M and NAG 24 hours after intervention was not significant in the two groups of asphyxiated preterm neonates (P > 0.05).GFR was significantly higher in neonates who received aminophylline on 4th day of life (P < 0.05) and it had trend to be significantly high on 7th day (P = 0.05) and was not significantly high on 1st day (P > 0.05) comparing with control group. The most common pathophysiology of renal failure was prerenal.



Aminophylline could prevent renal dysfunction in preterm neonates with asphyxia. Neonates who received aminophylin on the first day of life indicated a significant improvement in GFR and urine output.
International FItness Scale (IFIS): Construct Validity and Reliability in Women With Fibromyalgia: The al-Ándalus Project.

To examine the construct validity of the International FItness Scale (IFIS) (ie, self-reported fitness) against objectively measured physical fitness in women with fibromyalgia and in healthy women; and to study the test-retest reliability of the IFIS in women with fibromyalgia.



Cross-sectional study.



Fibromyalgia patient support groups.



Women with fibromyalgia (n=413) and healthy women (controls) (n=195) for validity purposes and women with fibromyalgia (n=101) for the reliability study. The total sample was N=709.



Not applicable.



Fitness level was both self-reported (IFIS) and measured using performance-based fitness tests. For the reliability study the IFIS was completed on 2 occasions, 1 week apart.



Women with fibromyalgia who reported average fitness had better measured fitness than those reporting very poor fitness (all P<.001, except 6-minute walk test where P<.05), with similar trends observed in healthy control women. The test-retest reliability of the IFIS, as measured by the average weighted κ, was .45.



The IFIS was able to identify women with fibromyalgia who had very low fitness and distinguish them from those with higher fitness levels. Furthermore, the IFIS was moderately reliable in women with fibromyalgia.
Neuroimmune Interaction and Anorectal Motility in Children With Food Allergy-Related Chronic Constipation

Food allergy is thought to trigger functional constipation in children but the underlying mechanisms are still unknown. Mast cells (MCs) and their relationship with nerve fibers (NFs) in the rectal mucosa, as well as anorectal motility, were studied in children with refractory chronic constipation before and after an elimination diet for cow's milk, egg, and soy proteins.Thirty-three children (range: 1–10.8 years) underwent anorectal manometry and suction rectal biopsy before and after 8 weeks of oligoantigenic diet. MCs and NFs were identified immunohistochemically. Quantification of MCs (%MC/area) and MCs within 10 μm of NFs (%MC-NF/area) was performed by computer-assisted analysis.Eighteen children responded to the diet (R-group) and fifteen did not (the NR-group). At baseline there was a significant difference in anal resting pressure (ARP; mm Hg), percentage of relaxation (%R), and residual pressure (RP; mm Hg) of anal canal during rectal distension between the R-group (66±4.1, 84.3±2.8, 10.4±2.3, respectively) and the NR-group (49±5, 92.2±1.7, 4.8±1.7, respectively; P<0.05). After the diet, significant changes in ARP, RP, and %R were observed only in the R-group (44±3.7, 93.7±1.5, 3.8±1.2, respectively; P<0.05). At baseline, the R-group showed an increase in %MC/area (8.3±0.7) and %MC-NF/area (5.2±2.6) with respect to the NR-group (5.1±0.5 and 2.3±0.4, respectively; P<0.05). After the diet, only the R-group showed a significant reduction of %MC/area and %MC-NF/area (4.4±0.5 and 2.2±0.4, respectively; P<0.001). Both ARP and RP significantly correlated with %MC/area and %MC-NF/area; %R showed a significant inverse correlation with both %MC/area and %MC-NF/area.In children with food allergy-related chronic constipation, an increase in both rectal MC density and spatial interactions between MCs and NFs correlates with anal motor abnormalities. These variables are significantly affected by the diet.
System factors affect the recognition and management of posttraumatic stress disorder by primary care clinicians.

Posttraumatic stress disorder (PTSD) is common with an estimated prevalence of 8% in the general population and up to 17% in primary care patients. Yet, little is known about what determines primary care clinician's (PCC's) provision of PTSD care.



To describe PCC's reported recognition and management of PTSD and identify how system factors affect the likelihood of performing clinical actions with regard to patients with PTSD or "PTSD treatment proclivity."



Linked cross-sectional surveys of medical directors and PCCs.



Forty-six medical directors and 154 PCCs in community health centers (CHCs) within a practice-based research network in New York and New Jersey.



Two system factors (degree of integration between primary care and mental health services, and existence of linkages with other community, social, and legal services) as reported by medical directors, and PCC reports of self-confidence, perceived barriers, and PTSD treatment proclivity.



Surveys from 47 (of 58) medical directors (81% response rate) and 154 PCCs (86% response rate). PCCs from CHCs with better mental health integration reported greater confidence, fewer barriers, and higher PTSD treatment proclivity (all P < 0.05). The PCCs in CHCs with better community linkages reported greater confidence, fewer barriers, higher PTSD treatment proclivity, and lower proclivity to refer patients to mental health specialists or to use a "watch and wait" approach (all P < 0.05).



System factors play an important role in PCC PTSD management. Interventions are needed that restructure primary care practices by making mental health services more integrated and community linkages stronger.
Value and limitations of peak-to-peak gradient for evaluation of aortic stenosis.

In patients with aortic stenosis (AS), it has been reported that the transvalvular pressure gradients (APs) may be reduced or even abolished in the presence of concomitant arterial hypertension, but the mechanisms underlying this phenomenon remain unclear. The study aim was to: (i) examine the relationship between systemic arterial hemodynamics and the peak-to-peak (deltaP(PtoP)), peak deltaP and mean deltaP; and (ii) propose and validate a new formula for the non-invasive estimation of the deltaP(PtoP) and of the peak left ventricular systolic pressure (LVSP) using Doppler echocardiography.



Two fixed stenoses (geometric orifice area 1.0 and 1.35 cm2) and one bioprosthesis (effective orifice area (EOA) 1.2 cm2) were tested in a mock flow circulation model. Systemic vascular resistance (R) was increased from 1,500 to 3,300 dyne.s/cm5, and systemic arterial compliance (C) was decreased from 2.9 to 0.9 ml/mmHg, while transvalvular flow was held constant.



Neither C nor R had any significant impact on EOA, peak deltaP and mean deltaP. deltaP(PtoP) was decreased markedly, however, when C was reduced (bioprosthesis: -15 mmHg (-69%); orifice 1.35 cm2: -24 mmHg (-30%); cm2: (-13%)). Subsequently, an equation was proposed to predict deltaP(PtoP) from EOA, mean deltaP, and C measured by Doppler echocardiography. LVSP calculated by adding the predicted deltaP(Ptop) to systolic arterial pressure (SAP) was compared with LVSP measured directly in a dataset of 24 pigs with experimentally induced AS. There was a strong agreement between the estimated and measured LVSP (r = 0.97; mean absolute error 5 +/- 5 mmHg).



deltaP(Ptop) should not be used to evaluate AS severity because, as opposed to peak and mean deltaPs, it is highly influenced by C. The new non-invasive method proposed in this study to estimate the LVSP may be useful for obtaining a more accurate estimate of global LV afterload in patients with AS.
Pathophysiological topography of acute ischemia by combined diffusion-weighted and perfusion MRI.

Combined echoplanar MRI diffusion-weighted imaging (DWI), perfusion imaging (PI), and magnetic resonance angiography (MRA) can be used to visualize acute brain ischemia and predict lesion evolution and functional outcome. The appearance of a larger lesion by PI than by DWI quantitatively defines a mismatch of potential clinical importance. Qualitative lesion variations exist in the topographic concordance of this mismatch. We examined both the topographic heterogeneity and relative frequency of mismatched patterns in acute stroke using these MRI techniques.



Acute DWI, PI, and MRA studies of 34 prospectively recruited patients with supratentorial ischemic lesions scanned within 24 hours of stroke onset (range 2.5 to 23.3 hours, 12 patients <6 hours) were analyzed.



Ischemic lesions were predominantly in the middle cerebral artery (MCA) territory (94%), with DWI lesions most commonly affecting the insular region. Mismatched patterns with PI lesion larger than DWI lesion occurred in 21 patients (62% overall), in all 4 patients imaged within 3 hours, and in 44% of patients imaged after 18 hours. A patient with a large PI but no DWI lesion and severe clinical deficit at 2.5 hours after stroke onset recovered completely. Regional variations in DWI and PI lesion loci were found, inferring site of proximal MCA occlusion, embolic pathogenesis, and regional arterial reperfusion.



Analysis of the topographic concordance of PI and DWI lesions in acute stroke reveals regional PI lesions without concomitant DWI lesions, which do not necessarily progress to infarction but may suggest stroke pathogenesis and site of current arterial occlusion. Location of DWI lesions may suggest an earlier site of arterial occlusion and regions of maximal perfusion deficit.
Psychometric properties of the Minnesota Living with Heart Failure—Brazilian version—in the elderly

Heart failure (HF) has implications for the quality of life for any age range, more so for the elderly who simultaneously present other limitations imposed by multiple co-morbidities. Although there are several instruments to measure Health Related Quality of Life (HRQL), none is specific to the elderly with HF. Among disease-specific instruments, Minnesota Living with Heart Failure(LHFQ) has not been studied extensively among the elderly with respect to its psychometric properties. The purpose of this study was to evaluate the convergent, divergent and discriminative validity of the Brazilian version of LHFQ applied to elderly HF patients. One hundred and seventy (170) elderly were interviewed. LHFQ capacity to discriminate subjects among New York Heart Association (NYHA) Classes I, II and III/IV was analyzed. Convergent and divergent validity was evaluated through the correlation between the domains of LHFQ and the generic instrument, Medical Outcomes Study (MOS) 36-item Short-Form Health Survey (SF-36). The LHFQ total score and physical dimension sub-scale discriminated between the three sub-groups of NYHA Classes I, II and III/IV (P < .0001). The emotional dimension discriminated NYHA Classes I and III/IV (P = .0034). The physical and emotional dimensions of the LHFQ and SF-36 were significantly correlated (coefficients from .46 to .70 for physical dimension and from .31 to .65 for emotional dimension). However, contrary to expectations, the divergent validity was not totally confirmed as there was no difference in the magnitude of the correlations between the LHFQ emotional and physical dimensions and the SF-36 role physical, social functioning and role emotional. Thus, the results suggest that LHFQ seems to be a valid tool to measure HRQL in the elderly, but new studies remain necessary to gain a better understanding of its discriminative validity for more advanced NYHA functional classes and for its divergent validity.
Association between eprosartan-based hypertension therapy and improvement in cognitive function score: long-term follow-up from the OSCAR observational study.

The Observational Study on Cognitive function And systolic blood pressure Reduction (OSCAR) was designed to evaluate the impact of eprosartan-based therapy on cognitive function in a cohort of 25,745 hypertensive subjects followed for six months.



In this supplementary analysis, we studied the relationship between eprosartan-based therapy and cognitive function (assessed using the Mini-Mental State Examination (MMSE)) after 12-month follow-up of 3600 patients (the long-term follow-up on-treatment population).



Reduction in blood pressure was sustained over 12 months, with mean systolic blood pressure/diastolic blood pressure 130.9/79 mmHg at one year, compared with 164.3/92.8 mmHg at baseline (p<0.001). The overall mean MMSE score at completion of 12-month follow-up was significantly increased from baseline (27.8 ± 2.7 vs. 26.3 ± 3.5; p<0.001). The increase in MMSE score was observed when the population was stratified by age (p<0.001) and in a subgroup of patients with cerebrovascular disease at baseline (n=290) (p<0.001, 12 months vs. baseline).



In this cohort of patients, use of eprosartan-based treatment for one year was associated with sustained reduction in blood pressure and stabilization or improvement of MMSE scores. These data are supportive of a role for blood pressure control in the prevention or delay of cognitive decline.
Sender-intended functions of emojis in US messaging

Emojis are an extremely common occurrence in mobile communications, but their meaning is open to interpretation. We investigate motivations for their usage in mobile messaging in the US. This study asked 228 participants for the last time that they used one or more emojis in a conversational message, and collected that message, along with a description of the emojis' intended meaning and function. We discuss functional distinctions between: adding additional emotional or situational meaning, adjusting tone, making a message more engaging to the recipient, conversation management, and relationship maintenance. We discuss lexical placement within messages, as well as social practices. We show that the social and linguistic function of emojis are complex and varied, and that supporting emojis can facilitate important conversational functions.