A stochastic model for studying the laminar structure of cortex from MRI
The human cerebral cortex is a laminar structure about 3 mm thick, and is easily visualized with current magnetic resonance (MR) technology. The thickness of the cortex varies locally by region, and is likely to be influenced by such factors as development, disease and aging. Thus, accurate measurements of local cortical thickness are likely to be of interest to other researchers. We develop a parametric stochastic model relating the laminar structure of local regions of the cerebral cortex to MR image data. Parameters of the model include local thickness, and statistics describing white, gray and cerebrospinal fluid (CSF) image intensity values as a function of the normal distance from the center of a voxel to a local coordinate system anchored at the gray/white matter interface. Our fundamental data object, the intensity-distance histogram (IDH), is a two-dimensional (2-D) generalization of the conventional 1-D image intensity histogram, which indexes voxels not only by their intensity value, but also by their normal distance to the gray/white interface. We model the IDH empirically as a marked Poisson process with marking process a Gaussian random field model of image intensity indexed against normal distance. In this paper, we relate the parameters of the IDH model to the local geometry of the cortex. A maximum-likelihood framework estimates the parameters of the model from the data. Here, we show estimates of these parameters for 10 volumes in the posterior cingulate, and 6 volumes in the anterior and posterior banks of the central sulcus. The accuracy of the estimates is quantified via Cramer-Rao bounds. We believe that this relatively crude model can be extended in a straightforward fashion to other biologically and theoretically interesting problems such as segmentation, surface area estimation, and estimating the thickness distribution in a variety of biologically relevant contexts.

title: Segmenting magnetic resonance images via hierarchical mixture modelling
abstract: We present a statistically innovative as well as scientifically and practically relevant method for automatically segmenting magnetic resonance images using hierarchical mixture models. Our method is a general tool for automated cortical analysis which promises to contribute substantially to the science of neuropsychiatry. We demonstrate that our method has advantages over competing approaches on a magnetic resonance brain imagery segmentation task.

title: Large deformation diffeomorphic metric mapping of fiber orientations
abstract: This paper proposes a method to match diffusion tensor magnetic resonance images (DT-MRI) through the large deformation diffeomorphic metric mapping of vector fields, focusing on the fiber orientations, considered as unit vector fields on the image volume. We study a suitable action of diffeomorphisms on such vector fields, and provide an extension of the large deformation diffeomorphic metric-mapping framework to this type of dataset, resulting in optimizing for geodesies on the space of diffeomorphisms connecting two images. Two different distance function of vector fields are considered. Existence of the minimizers under smoothness assumptions on the compared vector fields is proved, and coarse to fine hierarchical strategies are detailed, to reduce both ambiguities and computation load. This is illustrated by numerical experiments on DT-MRI heart and brain images

title: Information measures for object recognition accommodating signature variability
abstract: This paper presents measures characterizing the information content of remote observations of ground scenes imaged via optical and infrared sensors. Object recognition is posed in the context of deformable templates; the special Euclidean group is used to accommodate geometric variation of object pose. Principal component analysis of object signatures is used to represent and efficiently accommodate variation in object signature due to changes in the thermal state of the object surface. Mutual information measures, which are independent of the recognition system, are calculated quantifying both the information gain due to remote observations of the scene and the information loss due to signature variability. Signature model mismatch is quantitatively examined using the Kullback-Leibler divergence. Expressions are derived quadratically approximating the posterior conditional entropy on the orthogonal group for high signal-to-noise ratio. It is demonstrated that quadratic modules accurately characterize the posterior entropy for broad ranges of signal-to-mise ratio. Information gain in multiple-sensor scenarios is quantified, and it is demonstrated that the cost of signature uncertainty for the Comanche series of FLIR images collected by the US Army Night Vision Electronic Sensors Directorate is approximately 0.8 bits with an associated near doubling of mean-squared error uncertainty in pose.

title: Bayesian Segmentation via Asymptotic Partition Functions
abstract: Asymptotic approximations to the partition function of Gaussian random fields are derived. Textures are characterized via Gaussian random fields induced by stochastic difference equations determined by finitely supported, stationary, linear difference operators, adjusted to be nonstationary at the boundaries. It is shown that as the scale of the underlying shape increases, the log-normalizer converges to the integral of the log-spectrum of the operator inducing the random field. Fitting the covariance of the fields amounts to fitting the parameters of the spectrum of the differential operator-induced random field model. Matrix analysis techniques are proposed for handling textures with variable orientation. Examples of texture parameters estimated from training data via asymptotic maximum-likelihood are shown. Isotropic models involving powers of the Laplacian and directional models involving partial derivative mixtures are explored. Parameters are estimated for mitochondria and actin-myocin complexes in electron micrographs and clutter in forward-looking infrared images. Deformable template models are used to infer the shape of mitochondria in electron micrographs, with the asymptotic approximation allowing easy recomputation of the partition function as inference proceeds.

title: Individualizing Anatomical Atlases of the Head
abstract: This paper presents diffeomorphic transformations of 3D anatomical image data in human brains as imaged via magnetic resonance imagery. These transformations are generated in a hierarchical manner accommodating both global and local anatomical detail. The initial low-dimensional registration is accomplished by constraining the transformation to be in a low-dimensional basis. The basis is defined by the Green's function of the elasticity operator placed at predefined locations in the anatomy and the eigenfunctions of the elasticity operator. The high-dimensional, large-deformation registration is accomplished by minimizing the mismatch between the template (atlas) and target image volumes constrained by solving the Navier Stokes fluid model on a vector field.

title: Leveraging Channel Diversity for Key Establishment in Wireless Sensor Networks
abstract: As the use of sensor networks increases, security in this domain becomes a very real concern. One fundamental aspect of providing confidentiality and authentication is key distribution. While public-key encryption has provided these properties historically, sensors are resource constrained and benefit from symmetric key approaches. In this work, we propose a novel protocol for symmetric key distribution that uses the multiple channels available on sensor hardware. This channel diversity, along with spatial diversity of device locations, allows neighboring sensors to establish secure link keys from plaintext keys that are broadcast by sensors in their neighborhood. In particular, we show that using even one extra channel during the initialization procedure significantly improves the security of key establishment. Via analysis and simulation, we show that our protocol performs well in terms of network connectivity and resilience to colluding malicious devices, when compared to previous work. We show that our protocol can achieve over 90% connectivity among neighboring sensors with link keys that are uncompromised even when 80% of the devices in the network are malicious and collude. Finally, we present a thorough discussion of the comparative advantages and disadvantages of our approach compared to previous techniques.

title: Training Teams with Collaborative Agents
abstract: Training teams is an activity that is expensive, time-consuming, hazardous in some cases, and can be limited by availability of equipment and personnel. In team training, the focus is on optimizing interactions, such as efficiency of communication, conflict resolution and prioritization, group situation awareness, resource distribution and load balancing, etc. This paper presents an agent-based approach to designing intelligent team training systems. We envision a computer-based training system in which teams are trained by putting them through scenarios, which allow them to practice their team skills. There are two important roles that intelligent agents can play; these are as virtual team members and as coach. To carry out these functions, these agents must be equipped with an understanding of the task domain, the team structure, the selected decision-making process and their belief about other team members' mental states.

title: Paradigm Regained: Abstraction Mechanisms for Access Control
abstract: Access control systems must be evaluated in part on how well they enable one to distribute the access rights needed for cooperation, while simultaneously limiting the propagation of rights which would create vulnerabilities. Analysis to date implicitly assumes access is controlled only by manipulating a system’s protection state – the arrangement of the access graph. Because of the limitations of this analysis, capability systems have been ”proven” unable to enforce some basic policies: revocation, confinement, and the *-properties (explained in the text).

title: Almost Moore digraphs are diregular
abstract: An almost Moore digraph is a digraph of diameter k⩾2 , maximum out-degree d⩾2 and order n=d+d 2 +⋯+d k , that is, one less than the Moore bound. It is easy to show that the out-degree of an almost Moore digraph is constant (=d) . In this note we prove that also the in-degree of an almost Moore digraph is constant (=d) , that is, every almost Moore digraph is diregular of degree d .

title: Group Actions, Homeomorphisms, and Matching: A General Framework
abstract: This paper constructs metrics on the space of images I defined as orbits under group actions G. The groups studied include the finite dimensional matrix groups and their products, as well as the infinite dimensional diffeomorphisms examined in Trouvé (1999, Quaterly of Applied Math.) and Dupuis et al. (1998). Quaterly of Applied Math. Left-invariant metrics are defined on the product G × I thus allowing the generation of transformations of the background geometry as well as the image values. Examples of the application of such metrics are presented for rigid object matching with and without signature variation, curves and volume matching, and structural generation in which image values are changed supporting notions such as tissue creation in carrying one image to another.