Identifying reasoning strategies in medical decision making: A methodological guide
Reasoning strategies are a key component in many medical tasks, including decision making, clinical problem solving, and understanding of medical texts. Identification of reasoning strategies used by clinicians may prove critical to the optimal design of decision support systems. This paper presents a formal method of cognitive-semantic analysis for the identification and characterization of reasoning strategies deployed in medical tasks and demonstrates its use through specific examples. Although semantic analysis was originally developed in the investigation of knowledge structures, it can also be applied to identify the reasoning and decision processes used by physicians and medical trainees in clinical tasks. Assumptions underlying the methods, as well as illustrations of their use in diagnostic explanation tasks, are presented. We discuss semantic analysis in the context of the current interests in developing medical ontologies and argue that a frame-based propositional analytic methodology can provide a systematic way of addressing the construction of such ontologies. Although the application of propositional analysis methods has some limitations, we show how such limitations are being addressed and present some examples of information tools that have been developed to ease, and make more systematic, the process of analysis.

title: GLIF3: a representation format for sharable computer-interpretable clinical practice guidelines
abstract: The Guideline Interchange Format (GLIF) is a model for representation of sharable computer-interpretable guidelines. The current version of GLIF (GLIF3) is a substantial update and enhancement of the model since the previous version (GLIF2). GLIF3 enables encoding of a guideline at three levels: a conceptual flowchart, a computable specification that can be verified for logical consistency and completeness, and an implementable specification that is intended to be incorporated into particular institutional information systems. The representation has been tested on a wide variety of guidelines that are typical of the range of guidelines in clinical use. It builds upon GLIF2 by adding several constructs that enable interpretation of encoded guidelines in computer-based decision-support systems. GLIF3 leverages standards being developed in Health Level 7 in order to allow integration of guidelines with clinical information systems. The GLIF3 specification consists of an extensible object-oriented model and a structured syntax based on the resource description framework (RDF). Empirical validation of the ability to generate appropriate recommendations using GLIF3 has been tested by executing encoded guidelines against actual patient data. GLIF3 is accordingly ready for broader experimentation and prototype use by organizations that wish to evaluate its ability to capture the logic of clinical guidelines, to implement them in clinical systems, and thereby to provide integrated decision support to assist clinicians.

title: A two-stage algorithm for one-microphone reverberant speech enhancement
abstract: Under noise-free conditions, the quality of reverberant speech is dependent on two distinct perceptual components: coloration and long-term reverberation. They correspond to two physical variables: signal-to-reverberant energy ratio (SRR) and reverberation time, respectively. Inspired by this observation, we propose a two-stage reverberant speech enhancement algorithm using one microphone. In the first stage, an inverse filter is estimated to reduce coloration effects or increase SRR. The second stage employs spectral subtraction to minimize the influence of long-term reverberation. The proposed algorithm significantly improves the quality of reverberant speech. A comparison with a recent enhancement algorithm is made on a corpus of speech utterances in a number of reverberant conditions, and the results show that our algorithm performs substantially better.

title: Formal property verification by abstraction refinement with formal, simulation and hybrid engines
abstract: We present RFN, a formal property verification tool based on abstraction refinement. Abstraction refinement is a strategy for property verification. It iteratively refines an abstract model to better approximate the behavior of the original design in the hope that the abstract model alone will provide enough evidence to prove or disprove the property. However, previous work on abstraction refinement was only demonstrated on designs with up to 500 registers. We developed RFN to verify real-world designs that may contain thousands of registers. RFN differs from the previous work in several ways. First, instead of relying on a single engine, RFN employs multiple formal verification engines, including a BDD-ATPG hybrid engine and a conventional BDD-based fixpoint engine, for finding error traces or proving properties on the abstract model. Second, RFN uses a novel two-phase process involving 3-valued simulation and sequential ATPG to determine how to refine the abstract model. Third, RFN avoids the weakness of other abstraction-refinement algorithms-finding error traces on the original design, by utilizing the error trace of the abstract model to guide sequential ATPG to find an error trace on the original design. We implemented and applied a prototype of RFN to verify various properties of real-world RTL designs containing approximately 5,000 registers, which represents an order of magnitude improvement over previous results. On these designs, we successfully proved a few properties and discovered a design violation.

title: Synchronization in Relaxation Oscillator Networks with Conduction Delays
abstract: We study locally coupled networks of relaxation oscillators with excitatory connections and conduction delays and propose a mechanism for achieving zero phase-lag synchrony. Our mechanism is based on the observation that different rates of motion along different nullclines of the system can lead to synchrony in the presence of conduction delays. We analyze the system of two coupled oscillators and derive phase compression rates. This analysis indicates how to choose nullclines for individual relaxation oscillators in order to induce rapid synchrony. The numerical simulations demonstrate that our analytical results extend to locally coupled networks with conduction delays and that these networks can attain rapid synchrony with appropriately chosen nullclines and initial conditions. The robustness of the proposed mechanism is verified with respect to different nullclines, variations in parameter values, and initial conditions.

title: Clifford Algebraic Calculus for Geometric Reasoning with Application to Computer Vision
abstract: In this paper we report on our recent study of Clifford algebra for geometric reasoning and its application to problems in computer vision. A general framework is presented for construction and representation of geometric objects with selected rewrite rules for simplification. It provides a mechanism suitable for devising methods and software tools for geometric reasoning and computation. The feasibility and efficiency of the approach are demonstrated by our preliminary experiments on automated theorem proving in plane Euclidean geometry. We also explain how non-commutative Grobner bases can be applied to geometric theorem proving. In addition to several well-known geometric theorems, two application examples from computer vision are given to illustrate the practical value of our approach.

title: Clifford Term Rewriting for Geometric Reasoning in 3D
abstract: Clifford algebra formalism has been used recently in combination with standard term-rewriting techniques for proving many non-trivial geometric theorems. The key issue in this approach consists in verifying whether two Clifford expressions are equal. This paper is concerned with the generalization of the work to 3D geometric problems. A rewriting system is proposed and its theoretical properties are investigated. Some examples and potential applications are also presented.