Volumetric transformation of brain anatomy
Presents diffeomorphic transformations of three-dimensional (3-D) anatomical image data of the macaque occipital lobe and whole brain cryosection imagery and of deep brain structures in human brains as imaged via magnetic resonance imagery. These transformations are generated in a hierarchical manner, accommodating both global and local anatomical detail. The initial low-dimensional registration is accomplished by constraining the transformation to be in a low-dimensional basis. The basis is defined by the Green's function of the elasticity operator placed at predefined locations in the anatomy and the eigenfunctions of the elasticity operator. The high-dimensional large deformations are vector fields generated via the mismatch between the template and target-image volumes constrained to be the solution of a Navier-Stokes fluid model. As part of this procedure, the Jacobian of the transformation is tracked, insuring the generation of diffeomorphisms. It is shown that transformations constrained by quadratic regularization methods such as the Laplacian, biharmonic, and linear elasticity models, do not ensure that the transformation maintains topology and, therefore, must only be used for coarse global registration.

title: Segmenting magnetic resonance images via hierarchical mixture modelling
abstract: We present a statistically innovative as well as scientifically and practically relevant method for automatically segmenting magnetic resonance images using hierarchical mixture models. Our method is a general tool for automated cortical analysis which promises to contribute substantially to the science of neuropsychiatry. We demonstrate that our method has advantages over competing approaches on a magnetic resonance brain imagery segmentation task.

title: Individualizing Anatomical Atlases of the Head
abstract: This paper presents diffeomorphic transformations of 3D anatomical image data in human brains as imaged via magnetic resonance imagery. These transformations are generated in a hierarchical manner accommodating both global and local anatomical detail. The initial low-dimensional registration is accomplished by constraining the transformation to be in a low-dimensional basis. The basis is defined by the Green's function of the elasticity operator placed at predefined locations in the anatomy and the eigenfunctions of the elasticity operator. The high-dimensional, large-deformation registration is accomplished by minimizing the mismatch between the template (atlas) and target image volumes constrained by solving the Navier Stokes fluid model on a vector field.

title: Bayesian Segmentation via Asymptotic Partition Functions
abstract: Asymptotic approximations to the partition function of Gaussian random fields are derived. Textures are characterized via Gaussian random fields induced by stochastic difference equations determined by finitely supported, stationary, linear difference operators, adjusted to be nonstationary at the boundaries. It is shown that as the scale of the underlying shape increases, the log-normalizer converges to the integral of the log-spectrum of the operator inducing the random field. Fitting the covariance of the fields amounts to fitting the parameters of the spectrum of the differential operator-induced random field model. Matrix analysis techniques are proposed for handling textures with variable orientation. Examples of texture parameters estimated from training data via asymptotic maximum-likelihood are shown. Isotropic models involving powers of the Laplacian and directional models involving partial derivative mixtures are explored. Parameters are estimated for mitochondria and actin-myocin complexes in electron micrographs and clutter in forward-looking infrared images. Deformable template models are used to infer the shape of mitochondria in electron micrographs, with the asymptotic approximation allowing easy recomputation of the partition function as inference proceeds.

title: Clutter invariant ATR
abstract: One of the central problems in automated target recognition is to accommodate the infinite variety of clutter in real military environments. The principle focus of our paper is on the construction of metric spaces where the metric measures the distance between objects of interest invariant to the infinite variety of clutter. Such metrics are formulated using second-order random field models. Our results indicate that this approach significantly improves detection/classification rates of targets in clutter.

title: A stochastic model for studying the laminar structure of cortex from MRI
abstract: The human cerebral cortex is a laminar structure about 3 mm thick, and is easily visualized with current magnetic resonance (MR) technology. The thickness of the cortex varies locally by region, and is likely to be influenced by such factors as development, disease and aging. Thus, accurate measurements of local cortical thickness are likely to be of interest to other researchers. We develop a parametric stochastic model relating the laminar structure of local regions of the cerebral cortex to MR image data. Parameters of the model include local thickness, and statistics describing white, gray and cerebrospinal fluid (CSF) image intensity values as a function of the normal distance from the center of a voxel to a local coordinate system anchored at the gray/white matter interface. Our fundamental data object, the intensity-distance histogram (IDH), is a two-dimensional (2-D) generalization of the conventional 1-D image intensity histogram, which indexes voxels not only by their intensity value, but also by their normal distance to the gray/white interface. We model the IDH empirically as a marked Poisson process with marking process a Gaussian random field model of image intensity indexed against normal distance. In this paper, we relate the parameters of the IDH model to the local geometry of the cortex. A maximum-likelihood framework estimates the parameters of the model from the data. Here, we show estimates of these parameters for 10 volumes in the posterior cingulate, and 6 volumes in the anterior and posterior banks of the central sulcus. The accuracy of the estimates is quantified via Cramer-Rao bounds. We believe that this relatively crude model can be extended in a straightforward fashion to other biologically and theoretically interesting problems such as segmentation, surface area estimation, and estimating the thickness distribution in a variety of biologically relevant contexts.

title: Two Minimum Dominating Sets with Minimum Intersection in Chordal Graphs
abstract: We prove that the problem of finding two minimum dominating sets (connected dominating sets or clique transversals) with minimum intersection is polynomially solvable on interval graphs. Furthermore, the problem of deciding whether or not there exist two disjoint minimum dominating sets (connected dominating sets or clique transversals) is shown to be NP-hard for chordal graphs.

title: A characterization of strongly chordal graphs
abstract: In this paper, we present a simple charactrization of strongly chordal graphs. A chordal graph is strongly chordal if and only if every cycle on six or more vertices has an induced triangle with exactly two edges of the triangle as the chords of the cycle.

title: Group Actions, Homeomorphisms, and Matching: A General Framework
abstract: This paper constructs metrics on the space of images I defined as orbits under group actions G. The groups studied include the finite dimensional matrix groups and their products, as well as the infinite dimensional diffeomorphisms examined in Trouvé (1999, Quaterly of Applied Math.) and Dupuis et al. (1998). Quaterly of Applied Math. Left-invariant metrics are defined on the product G × I thus allowing the generation of transformations of the background geometry as well as the image values. Examples of the application of such metrics are presented for rigid object matching with and without signature variation, curves and volume matching, and structural generation in which image values are changed supporting notions such as tissue creation in carrying one image to another.

title: Almost Moore digraphs are diregular
abstract: An almost Moore digraph is a digraph of diameter k⩾2 , maximum out-degree d⩾2 and order n=d+d 2 +⋯+d k , that is, one less than the Moore bound. It is easy to show that the out-degree of an almost Moore digraph is constant (=d) . In this note we prove that also the in-degree of an almost Moore digraph is constant (=d) , that is, every almost Moore digraph is diregular of degree d .

title: A MAC protocol to reduce sensor network energy consumption using a wakeup radio
abstract: For increasing the life of sensor networks, each node must conserve energy as much as possible. In this paper, we propose a protocol in which energy is conserved by amortizing the energy cost of communication over multiple packets. In addition, we allow sensors to control the amount of buffered packets since storage space is limited. To achieve this, a two-radio architecture is used which allows a sensor to "wakeup" a neighbor with a busy tone and send its packets for that destination. However, this process is expensive because all neighbors must awake and listen to the primary channel to determine who is the intended destination. Therefore, triggered wakeups on the primary channel are proposed to avoid using the more costly wakeup procedure. We present a protocol for efficiently determining how large the period for these wakeups should be such that energy consumption is reduced.