nils-herrmann/clean_scirepeval huggingface dataset:
Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium
Venue: JAMA psychiatry
Year: 2018

Importance Given the rapidly increasing use of stimulant medications during pregnancy and among women of reproductive age who may become pregnant inadvertently, there is a need to better understand their safety.  To examine the risk of congenital malformations associated with intrauterine exposure to stimulants.  Medicaid Analytic eXtract, with follow up of safety signals detected in the Medicaid Analytic eXtract data using the Nordic Health registries (2003 2013) (Denmark, Finland, Iceland, Norway, and Sweden) A total of 1 813 894 publicly insured pregnancies in the United States and 2 560 069 singleton pregnancies in the 5 Nordic countries ending in live births were included. Relative risks were estimated accounting for underlying psychiatric disorders and other potential confounders. Relative risk estimates for the US and Nordic data were pooled using a fixed effects meta analytic approach. The study was conducted from July 1, 2015, to March 31, 2017.  Methylphenidate and amphetamines dispensed during the first trimester.  Major congenital malformations and subgroup of cardiac malformations.  In the US data, of the 1 813 894 pregnancies evaluated, 35.0 per 1000 infants not exposed to stimulants were diagnosed as having congenital malformations, compared with 45.9 per 1000 infants for methylphenidate and 45.4 for amphetamines. For cardiac malformations, the risks were 12.7 (95% CI, 12.6 12.9) 18.8 (95% CI, 13.8 25.6) and 15.4 (95% CI, 12.5 19.0) per 1000 infants, respectively. The adjusted relative risks for methylphenidate were 1.11 (95% CI, 0.91 1.35) for any malformation and 1.28 (95% CI, 0.94 1.74) for cardiac malformations. No increased risks were observed for amphetamines: 1.05 (95% CI, 0.93 1.19) for any malformations and 0.96 (95% CI, 0.78 1.19) for cardiac malformations. Findings were confirmed in sensitivity analyses accounting for proxies of unmeasured confounders and increasing the specificity of the exposure and outcome definitions. Replication of the analyses for methylphenidate using the Nordic data including 2 560 069 pregnancies yielded a relative risk of 1.28 (95% CI, 0.83 1.97) for cardiac malformations, resulting in a pooled estimate of 1.28 (95% CI, 1.00 1.64)  These findings suggest a small increase in the risk of cardiac malformations associated with intrauterine exposure to methylphenidate but not to amphetamines. This information is important when weighing the risks and benefits of alternative treatment strategies for attention deficit/hyperactivity disorder in women of reproductive age and during early pregnancy.
EVALUASI PERENCANAAN OBAT ANTIBIOTIK DI INSTALASI FARMASI RUMAH SAKIT ORTOPEDI PROF. DR. R. SOEHARSO SURAKARTA TAHUN 2017
Year: 2018

Drug planning is an effort to determine the type, quantity, and quality of the drug as needed. Antibiotics are used as the main therapy in the case of bacterial infections, so it needs good planning to control the supply. This study aims to compare the results of antibiotic drug planning with the procurement of antibiotic drugs in 2017 to improve the efficiency of procurement of antibiotics in Pharmacy Installation of Orthopedic Hospital Prof. Dr. R. Soeharso Surakarta. This research is a non experimental research conducted retrospectively and evaluated by consumption method. Evaluation of planning done by collecting data of antibiotic drug in 2016 then calculated by formula of consumption method, taking into account the existence of factors influencing amount of drug procurement in Pharmacy Installation of Orthopedic Hospital Prof. Dr. R. Soeharso Surakarta during 2017. Data were analyzed based on the Drug Management Indicators in the Hospital. Using medication management indicators in hospitals, the results showed that the percentage of drug procurement allocation was 21.9% the frequency of procurement of medicines per item per year was 5.89 times, the percentage of the number of medicinal items held with the planned 57.43% Keywords: planning, procurement, antibiotics
Simultaneous micro electromembrane extractions of anions and cations using multiple free liquid membranes and acceptor solutions.
Venue: Analytica chimica acta
Year: 2016

Micro electromembrane extractions (m EMEs) across free liquid membranes (FLMs) were applied to simultaneous extractions of anions and cations. A transparent narrow bore polymeric tubing was filled with adjacent plugs of mL volumes of aqueous and organic solutions, which formed a stable five phase m EME system. For the simultaneous m EMEs of anions and cations, aqueous donor solution was the central phase, which was sandwiched between two organic FLMs and two aqueous acceptor solutions. On application of electric potential, anions and cations in the donor solution migrated across the two FLMs and into the two peripheral acceptor solutions in the direction of anode and cathode, respectively. Visual monitoring of anionic (tartrazine) and cationic (phenosafranine) dye confirmed their simultaneous m EMEs and their rapid (in less than 5 min) transfers into anolyte and catholyte, respectively. The concept of simultaneous m EMEs was further examined with selected model analytes; KClO4 was used for m EMEs of inorganic anions and cations and ibuprofen and procaine for m EMEs of acidic and basic drugs. Quantitative analyses of the resulting acceptor solutions were carried out by capillary electrophoresis with capacitively coupled contactless conductivity detection (CE C(4)D) Good extraction recoveries (91 94% and repeatability of peak areas =6.3% were achieved for 5 min m EMEs of K( and ClO4( Extraction recoveries and repeatability of peak areas for 5 min m EMEs of ibuprofen and procaine were also satisfactory and ranged from 35 to 63% and 7.6 to 11.3% respectively. Suitability of the presented micro extraction procedure was further demonstrated on simultaneous m EMEs with subsequent CE C(4)D of ibuprofen and procaine from undiluted human urine samples.
Robotic transformative service research: deploying social robots for consumer well being during COVID 19 and beyond
Year: 2020

Besides the direct physical health consequences, through social isolation COVID 19 affects a considerably larger share of consumers with deleterious effects for their psychological well being Two vulnerable consumer groups are particularly affected: older adults and children The purpose of the underlying paper is to take a transformative research perspective on how social robots can be deployed for advancing the well being of these vulnerable consumers and to spur robotic transformative service research (RTSR)  This paper follows a conceptual approach that integrates findings from various domains: service research, social robotics, social psychology and medicine  Two key findings advanced in this paper are (1) a typology of robotic transformative service (i e entertainer, social enabler, mentor and friend) as a function of consumers' state of social isolation, well being focus and robot capabilities and (2) a future research agenda for RTSR  This paper guides service consumers and providers and robot developers in identifying and developing the most appropriate social robot type for advancing the well being of vulnerable consumers in social isolation  This study is the first to integrate social robotics and transformative service research by developing a typology of social robots as a guiding framework for assessing the status quo of transformative robotic service on the basis of which it advances a future research agenda for RTSR It further complements the underdeveloped body of service research with a focus on eudaimonic consumer well being (c) 2020, Alexander P Henkel, Martina Caic, Marah Blaurock and Mehmet Okan
KIM 1/TIM 1 is a Receptor for SARS CoV 2 in Lung and Kidney
Venue: medRxiv
Year: 2020

SARS CoV 2 precipitates respiratory distress by infection of airway epithelial cells and is often accompanied by acute kidney injury. We report that Kidney Injury Molecule 1/T cell immunoglobulin mucin domain 1 (KIM 1/TIM 1) is expressed in lung and kidney epithelial cells in COVID 19 patients and is a receptor for SARS CoV 2. Human and mouse lung and kidney epithelial cells express KIM 1 and endocytose nanoparticles displaying the SARS CoV 2 spike protein (virosomes) Uptake was inhibited both by anti KIM 1 antibodies and by TW 37, our newly discovered inhibitor of KIM 1 mediated endocytosis. Enhanced KIM 1 expression by human kidney tubuloids increased uptake of virosomes. KIM 1 positive cells express less angiotensin converting enzyme 2 (ACE2) the well known receptor for SARS CoV 2. Using microscale thermophoresis, the EC50 for KIM 1 SARS CoV 2 spike protein, and receptor binding domain (RBD) interactions, were 19 and 10 nM respectively. Thus KIM 1 is an alternative receptor to ACE2 for SARS CoV 2. KIM 1 targeted therapeutics may prevent and/or treat COVID 19.
An Efficient IoT Based Patient Monitoring and Heart Disease Prediction System Using Deep Learning Modified Neural Network
Venue: IEEE Access
Year: 2020

The leading causes of death worldwide are chronic illnesses suchlike diabetes, Heart Disease (HD) cancer as well as chronic respiratory malady. It is remarkably intricate to diagnose HD with disparate symptoms or features. With the augmentation in popularity of smart wearable gadgets, a chance to render an Internet of Things (IoT) solution has turned out to be more. Unfortunately, the survival rates are low for the people suffering from sudden heart attacks. Consequently, a patient monitoring scheme intended for heart patients utilizing IoT centered Deep Learning Modified Neural Network (DLMNN) is proposed to assist in the HD diagnosis, and medication is given accordingly. This proposed technique is executed via '3' steps: I) Authentication, ii) Encryption, and iii) Classification. First, by utilizing the substitution cipher (SC) together with the SHA 512, the heart patient of the specific hospital is authenticated. Subsequently, the wearable IoT sensor device, which is fixed to the patient's body, concurrently transmits the sensor data to the cloud. This sensor data is encrypted and securely transmitted to the cloud utilizing the PDH AES technique. After that, the encrypted data is finally decrypted, and by employing the DLMNN classifier, the classification is done. The classified outcomes comprise '2'types of data: i) normal and ii) abnormal. It denotes the patient's heart condition and if the outcome is abnormal, an alert text is passed to the physician for treating the patient. The investigational outcomes are estimated and the DLMNN for HD diagnosis shows improvement as compared to existing algorithms. Additionally, the proposed PDH AES used in support of secure data transmission results in the highest level of security i.e. 95.87% and it is achieved in the lowest time for encryption along with decryption when weighted against the existent AES.
Trauma management therapy with virtual reality augmented exposure therapy for combat related PTSD: A randomized controlled trial.
Venue: Journal of anxiety disorders
Year: 2019

Virtual reality exposure therapy (VRET) realistically incorporates traumatic cues into exposure therapy and holds promise in the treatment of combat related posttraumatic stress disorder (PTSD) In a randomized controlled trial of 92 Iraq and Afghanistan veterans and active duty military personnel with combat related PTSD, we compared the efficacy of Trauma Management Therapy (TMT; VRET plus a group treatment for anger, depression, and social isolation) to VRET plus a psychoeducation control condition. Efficacy was evaluated at mid and post treatment, and at 3 and 6 month follow up. Consistent with our hypothesis, VRET resulted in significant decreases on the Clinician Administered PTSD Scale and the PTSD Checklist Military version for both groups. Also consistent with our hypothesis, significant decreases in social isolation occurred only for those participants who received the TMT group component. There were significant decreases for depression and anger for both groups, although these occurred after VRET and before group treatment. All treatment gains were maintained six months later. Although not part of the original hypotheses, sleep was not improved by either intervention and remained problematic. The results support the use of VRET as an efficacious treatment for combat related PTSD, but suggest that VRET alone does not result in optimal treatment outcomes across domains associated with PTSD.
Validation of a self administered FFQ in adults in Argentina, Chile and Uruguay
Venue: Public Health Nutrition
Year: 2014

To assess the reproducibility and validity among adults in the Southern Cone of Latin America (Argentina, Chile and Uruguay) of a self administered FFQ to be used in the CESCAS I Study, an ongoing observational prospective cohort study to detect and follow up CVD and their risk factors, as well as in other epidemiological studies.  Relative validity of the FFQ was evaluated by comparing nutrient and selected food group intakes with those from three 24 h recalls (24HR) administered over 6 months. The FFQ was administered at baseline (FFQ1) and again after 3 months (FFQ2) Setting Primary care centres in Argentina, Chile and Uruguay. Subjects Adults (n 147) aged 21 74 years.  Reproducibility (FFQ1 v. FFQ2) the intra class correlation coefficients for nutrients ranged from 0*52 (potassium) to 0*74 (fat) Validity (FFQ1 v. the average of three 24HR) the Pearson correlations for energy adjusted nutrients ranged from 0*39 (thiamin and cholesterol) to 0*59 (carbohydrate) Joint classification: overall, 66 of participants in the lowest 24HR quintile were in the lowest one or two FFQ1 quintiles, and 62 of those in the highest 24HR quintile were in the highest one or two FFQ1 quintiles. On average, only 4 were misclassified into extreme quintiles.  The FFQ version for the Southern Cone seems to present moderate to acceptable relative validity and reliability for its use in the CESCAS I Study to measure dietary exposure.
Long Term Follow Up in Patients With Stable Angina and Unobstructed Coronary Arteries Undergoing Intracoronary Acetylcholine Testing.
Venue: JACC. Cardiovascular interventions
Year: 2020

The aim of this study was to investigate the prognosis of a large cohort of patients with stable angina and unobstructed coronaries undergoing acetylcholine spasm testing.  Coronary artery spasm can be found in up to 60% of patients with symptoms of myocardial ischemia despite unobstructed coronary arteries.  Consecutive symptomatic patients with unobstructed coronary arteries undergoing acetylcholine testing to detect epicardial or microvascular coronary spasm were prospectively enrolled. After a median follow up period of 7.2 years (6.5 to 7.9 years) data regarding mortality, nonfatal myocardial infarction, stroke, repeat coronary angiography, recurrent symptoms, and quality of life were obtained in 736 patients (57% women, mean age 62 12 years) RESULTS In total, 55 deaths (7.5% 8 nonfatal myocardial infarctions (1.4% and 12 strokes (2.2% occurred during the follow up period. Recurrent symptoms were reported by 64% of patients, and repeat coronary angiography was performed in 12% of cases. Multivariate analysis revealed epicardial spasm as a predictor of nonfatal myocardial infarction (hazard ratio: 14.469; 95% confidence interval: 1.735 to 120.646) and repeat angiography (hazard ratio: 1.703; 95% confidence interval: 1.062 to 2.732) whereas patients with microvascular spasm more often had recurrent angina at follow up (hazard ratio: 1.311; 95% confidence interval: 1.013 to 1.697)  In this long term follow up study, the overall prognosis of patients with coronary spasm was favorable. Patients with epicardial spasm were at increased risk for myocardial infarction and repeat angiography, while microvascular spasm was associated with recurrent angina. Acetylcholine testing may help identify patients at increased risk for adverse cardiac events among this overall low risk population.
Vascular Adaptation: Pattern Formation and Cross Validation between an Agent Based Model and a Dynamical System.
Venue: Journal of theoretical biology
Year: 2017

Myocardial infarction is the global leading cause of mortality (Go et al. 2014) Coronary artery occlusion is its main etiology and it is commonly treated by Coronary Artery Bypass Graft (CABG) surgery (Wilson et al, 2007) The long term outcome remains unsatisfactory (Benedetto, 2016) as the graft faces the phenomenon of restenosis during the post surgery, which consists of re occlusion of the lumen and usually requires secondary intervention even within one year after the initial surgery (Harskamp, 2013) In this work, we propose an extensive study of the restenosis phenomenon by implementing two mathematical models previously developed by our group: a heuristic Dynamical System (DS) (Garbey and Berceli, 2013) and a stochastic Agent Based Model (ABM) (Garbey et al. 2015) With an extensive use of the ABM, we retrieved the pattern formations of the cellular events that mainly lead the restenosis, especially focusing on mitosis in intima, caused by alteration in shear stress, and mitosis in media, fostered by alteration in wall tension. A deep understanding of the elements at the base of the restenosis is indeed crucial in order to improve the final outcome of vein graft bypass. We also turned the ABM closer to the physiological reality by abating its original assumption of circumferential symmetry. This allowed us to finely replicate the trigger event of the restenosis, i.e. the loss of the endothelium in the early stage of the post surgical follow up (Roubos et al. 1995) and to simulate the encroachment of the lumen in a fashion aligned with histological evidences (Owens et al. 2015) Finally, we cross validated the two models by creating an accurate matching procedure. In this way we added the degree of accuracy given by the ABM to a simplified model (DS) that can serve as powerful predictive tool for the clinic.
Implications of dredging induced changes in sediment particle size composition for the structure and function of marine benthic macrofaunal communities.
Venue: Marine pollution bulletin
Year: 2011

A meta analysis approach was used to assess the effect of dredging induced changes in sediment composition, under different conditions of natural physical disturbance, for the structure and function of marine benthic macrofaunal communities. Results showed the sensitivity of macrofaunal communities increased as both the proportion of gravel increased and the level of natural physical disturbance decreased. These findings may be explained by the close association of certain taxa with the gravel fraction, and the influence of natural physical disturbance which, as it increases, tends to restrict the colonisation by these species. We conclude that maintaining the gravel content of surface sediments after dredging and, where practicable, locating extraction sites in areas of higher natural disturbance will minimise the potential for long term negative impacts on the macrofauna.
Calling for translation literacy: The use of covert translation in student academic writing in higher education
Year: 2018

When Danish university students write essays, project reports or theses in their L1, based on a reading of sources in English as an L2, a covert interlingual translation process takes place when summarizing, paraphrasing or synthesizing the sources. Unfortunately, due to poor L2 reading skills as well as general translation competences, the English source texts risk being mistranslated in such a way that they are misrepresented. Thus, I suggest that we address the need for translation literacy, this being viewed as an academic skill, a language awareness learning process and a discourse practice in the international university context, which is increasingly relying on research published in English. Based on an empirical analysis of student academic writing, I argue that translation literacy is needed when teaching academic reading for writing in higher education in general. Mastering translation competences may facilitate more in depth understanding of the foreign language sources used as well as raise students' intercultural awareness in a multilingual world at large.
Leveraging State Owned Nature Based Assets for Transformation and SMME Development: Pilanesberg National Park, South Africa
Venue: New Directions in South African Tourism Geographies
Year: 2019

Small firm development issues are a major theme in international tourism scholarship. The South African experience is of special interest because of the national government's need to address the apartheid legacy of the exclusion of Black communities from participation as entrepreneurs in the mainstream tourism economy. Several supply side support programmes have been initiated to assist in the development of Black owned SMMEs. In addition, a new policy direction is to leverage state owned assets to expand the participation of Black entrepreneurs in the tourism economy particularly in supply chains. The core aim of this chapter is to explore the leveraging possibilities of one major state asset in nature tourism and the associated challenges for increasing the participation of Black owned SMMEs into South Africa's tourism economy. The specific focus here is to analyse the challenges for developing a more inclusive tourism economy in the context of the Pilanesberg National Park. Using a mixed method approach, consisting of interviews and questionnaires, this chapter analyses the challenges both from a supply and demand perspective. The findings show few linkages exist between this state owned asset and local SMMEs, that local SMMEs are unable to meet the demands required by the facilities within the Pilanesberg National Park, and that limits exist on the influence that state agencies can exert on procurement by operating facilities in the park.
Nicolai Hartmanns Kritische Ontologie ,wie sie als Grundlage der Gnoseologie anzustreben ist" und der Kritische Realismus der Gestaltpsychologie ,Berliner Schule"/Gestalttheorie)
Year: 2018

The author exemplifies the congruency of essential foundations between the critical realism of the Berlin School of Gestalt Psychology (Gestalt theory) and Nicolai Hartmann`s Critical Ontology. For instance, this congruency manifests in the importance given to critical realistic epistemology purified from idealistic prejudices, not least prejudices such as production theoretical ones connected with an unconditional phenomenology. Altogether, it results in a shared critical distance from scholars of Brentano, such as Husserl and Meinong, as well as from Neo Kantianism.
PENGARUH CITRA MEREK (BRAND IMAGE) KUALITAS PRODUK, PERSEPSI HARGA, PROMOSI PENJUALAN TERHADAP KEPUTUSAN PEMBELIAN PRODUK HONDA DI MPM MOTOR
Year: 2019

This study aims to examine and analyze the influence of brand image Product Quality, Price Perception, Sales Promotion o n The Purchase Decision o f Honda Products i n Mpm Motor. Population and sample in this study were 78. The method s to collect the data was questionnaire. Data analysis in this study used SPSS version 14. In this study the application used to test the data were " validity test, reliability test, Normality test, multiple linear regression analysis, classical assumption test, and testing the research hypothesi s" The result in this study indicated that Brand image and Sales Promotion have a significant effect on Honda MPM Motor Purchase Decisions. Product Quality and Price perception have no significant effect on purchasing decisions  Product Quality, Price Perception, Sales Promotion On The Purchase Decision