nils-herrmann/clean_scirepeval huggingface dataset:
Antibiotics induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility
Venue: Journal of Translational Medicine
Year: 2016

BackgroundThe gastrointestinal motility is affected by gut microbiota and the relationship between them has become a hot topic. However, mechanisms of microbiota in regulating motility have not been well defined. We thus investigated the effect of microbiota depletion by antibiotics on gastrointestinal motility, colonic serotonin levels, and bile acids metabolism.MethodsAfter 4 weeks with antibiotics treatments, gastrointestinal and colon transit, defecation frequency, water content, and other fecal parameters were measured and analyzed in both wild type and antibiotics treated mice, respectively. Contractility of smooth muscle, serotonin levels, and bile acids levels in wild type and antibiotics treated mice were also analyzed.ResultsAfter antibiotics treatment, the richness and diversity of intestinal microbiota decreased significantly, and the fecal of mice had less output (P 0.01) more water content (P 0.01) and longer pellet length (P 0.01) Antibiotics treatment in mice also resulted in delayed gastrointestinal and colonic motility (P 0.05) and inhibition of phasic contractions of longitudinal muscle from isolated proximal colon (P 0.01) In antibiotics treated mice, serotonin, tryptophan hydroxylase 1, and secondary bile acids levels were decreased.ConclusionGut microbiota play an important role in the regulation of intestinal bile acids and serotonin metabolism, which could probably contribute to the association between gut microbiota and gastrointestinal motility as intermediates.
PERAN PERKEMBANGAN KEGIATAN INDUSTRI DAN PERDAGANGAN JASA TERHADAP PERUBAHAN STRUKTUR RUANG KAWASAN SOLO BARU
Year: 2017

800x600 Solo Baru area is a satellite city that grew due to the phenomenon of u r ban sprawl in Surakarta This area growth of more advanced and dominated by economic activity, especially industrial and trade services activities The problem is d evelopment on industrial and trade services activities occur in Solo Baru certainly will encourage a change in the spatial area as centers of activit ies patterns of land use and road network Changes in the spatial aspect will have a negative impact on the regularity of the spatial structure and function of the area to the surrounding area. Therefore, this research was conducted to determine the role of the development of industrial and trade services activities to the changes in the spatial structure of Solo Baru area The method of research is deductive quantitative while the data analisys technique used is descriptive analysis of quantitative and spatial descriptive. The results of this study notes that both of industrial and trade services activities have developed from years 2002 2014 that occurred development of industrial activity by 43% and trade services activities amounted to 140% The role of the development of industrial and trade services activities include the agglomeration of activities and to encourage a change in the distribution centers that changes occur in the central sub central models that undergo a change from a non centered to form multi nodal. In addition, the industrial and trade services activities also encourage land use changes and then give impact to the shift and functional zoning exist within the area as well as attract more movement leads to a change in the function and capacity of the road network Normal 0 false false false IN X NONE X NONE Style Definitions table.MsoNormalTable {mso style name:"Table Normal" mso tstyle rowband size:0; mso tstyle colband size:0; mso style noshow:yes; mso style priority:99; mso style parent:" mso padding alt:0cm 5.4pt 0cm 5.4pt; mso para margin:0cm; mso para margin bottom:.0001pt; mso pagination:widow orphan; font size:10.0pt; font family:"Times New Roman""serif"
Customer retention in the medical tourism industry: Impact of quality, satisfaction, trust, and price reasonableness
Year: 2015

Repeat business is critical to the success of medical clinics in the competitive medical tourism market. This study develops a model explaining international medical travelers' intention formation by considering the impact of quality, satisfaction, trust, and price reasonableness. A field survey was conducted at medical clinics. Findings from structural analysis indicate a good fit for the proposed model; perceived quality, satisfaction, and trust in the staff and clinic have significant associations affecting intentions to revisit clinics and the destination country; and satisfaction and trust acted as significant mediators. In general, support for the hypothesized moderating impact of price reasonableness in the proposed theoretical model was evident in the results of the metric invariance test. Implications for theory and practice are discussed.
The Critical Care Society of Southern Africa Consensus Guideline on ICU Triage and Rationing (ConICTri)
Venue: South African medical journal Suid Afrikaanse tydskrif vir geneeskunde
Year: 2019

In South Africa (SA) administrators and intensive care practitioners are faced with the challenge of resource scarcity as well as an increasing demand for intensive care unit (ICU) services. ICU services are expensive, and practitioners in low to middle income countries experience the consequences of limited resources daily. Critically limited resources necessitate that rationing and triage (prioritisation) decisions are routinely necessary in SA, particularly in the publicly funded health sector.  The purpose of this guideline is to utilise the relevant recommendations of the associated consensus meeting document and other internationally accepted principles to develop a guideline to inform frontline triage policy and ensure the best utilisation of adult intensive care in SA, while maintaining the fair distribution of available resources. Recommendations. An overall conceptual framework for the triage process was developed. The components of the framework were developed on the basis that patients should be admitted preferentially when the likely incremental medical benefit derived from ICU admission justifies admission. An estimate of likely resource use should also form part of the triage decision, with those patients requiring relatively less resources to achieve substantial benefit receiving priority for admission. Thus, the triage system should maximise the benefits obtained from ICU resources available for the community. Where possible, practical examples of what the consensus group agreed would be considered appropriate practice under specified South African circumstances were provided, to assist clinicians with practical decision making. It must be stressed that this guideline is not intended to be prescriptive for individual hospital or regional practice, and hospitals and regions are encouraged to develop specified local guidelines with locally relevant examples. The guideline should be reviewed and revised if appropriate within 5 years.  In recognition of the absolute need to limit patient access to ICU because of the lack of sufficient intensive care resources in public hospitals, this guideline has been developed to guide policy making and assist frontline triage decision making in SA. This document is not a complete plan for quality practice, but rather a template to support frontline clinicians, guide administrators and inform the public regarding appropriate triage decision making.
Wrist pulse measurement and analysis using Eulerian video magnification
Venue: 2016 IEEE EMBS International Conference on Biomedical and Health Informatics (BHI)
Year: 2016

The wrist pulse reveals important information on the health status of a subject. The morphology and characteristics of the wrist pulse play a significant role in analyzing and diagnosing abnormal health conditions. In ancient China, measuring the wrist pulse was considered an important part of the traditional Chinese medicine. Recent studies attempted to quantify this ancient diagnostic technique and proposed several approaches to extract useful information from the wrist pulse signal. In this paper, a digital camera is used to record standard videos of the wrist. The Eulerian video magnification method is employed to detect, non intrusively, the wrist pulse signals. Then the 2 Gaussian curve modeling method is applied to analyze the signals. Spatial decomposition and temporal filtering are then used on the frames of the recorded videos. The subtle motion and color changes that correlate with the blood flowing through the artery are visualized through amplifying the filtered signal. To verify the performance of the Eulerian video magnification method for detecting the wrist pulse signal, the photoplethysmogram (PPG) pulse signal was measured. The two signals were recorded simultaneously and were compared. The experimental results demonstrate that the Eulerian video magnification method can be used to capture the characteristics of the wrist pulse signal and has the potential for predicting important cardiovascular events.
Robot assisted laparoendoscopic single site adrenalectomy
Venue: Medicine
Year: 2017

Laparoscopic adrenalectomy is currently the standard of care for adrenal lesion. Minimal invasive laparoscopic surgery such as laparoendoscopic single site surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES) have been developed to improve cosmetic outcomes and reduce postoperative pain. However, there are still some problems related to instruments and port limitation during LESS surgery. Robot assisted laparoscopic surgery may help to overcome these problems, and port platforms selection is an important issue.  Three cases received robot assisted LESS adrenalectomy due to adrenal tumor were enrolled. Blood loss, hospital stay, and analgesia injection were compared.  Preoperative evaluations were done in a usual manner. Benign tumors were suspect for two patients, while metastatic tumor could not be excluded for the other patient with prior malignancy history. The pathology reports were all benign adrenal cortical adenoma after operation.  Three different port platforms, Da Vinci Single Site Surgical Platform, GelPOINT, and homemade glove port were used. Trans peritoneal approach was used for two patients, while the other one received trans retroperitoneal approach. The advantage and disadvantage of different port platforms were discussed.  All patients underwent the operation smoothly without major complications or conversion to open surgery. Blood loss amount was small, hospital stay was short, and only one patient received one single dose of opioid analgesia injection after the surgery.  The main problems of LESS are the loss of a working triangle and the limitations of the instruments. Robot assisted LESS may help surgeons overcome part of these problems. Many different port platforms are available, and based on our initial experience, we believe that the GelPoint may be a more suitable platform, for it maintains the endo wrist function of the Da Vinci instruments, and allows the surgeon to design the position of ports freely to minimize external and internal collision.
An Efficient DNA Extraction Protocol for Successful PCR Detection of Banana bunchy top virus from Banana Leaves
Year: 2015

Banana bunchy top virus (BBVT) is the most threatening disease of banana all over the world. Control of BBTV involves the use of disease free planting material and prevention of infection. Its accurate detection is one of the functional approach to control it by eradication and exclusion. PCR is the most efficient mode of indexing but high quality of DNA is one of the most essential factor for a successful amplification by PCR. In this study, we have developed a highly efficient low cost and rapid DNA extraction method for banana tissue which could yield good quantity of DNA free from protein and polysaccharide contamination. The DNA extracted by this method could be successfully amplified by PCR. In addition, the protocol could be completed within ~2 h.
RDSZ: An Approach for Lossless RDF Stream Compression
Venue: ESWC
Year: 2014

In many applications (like social or sensor networks) the information generated can be represented as a continuous stream of RDF items, where each item describes an application event (social network post, sensor measurement, etc) In this paper we focus on compressing RDF streams. In particular, we propose an approach for lossless RDF stream compression, named RDSZ (RDF Differential Stream compressor based on Zlib) This approach takes advantage of the structural similarities among items in a stream by combining a differential item encoding mechanism with the general purpose stream compressor Zlib. Empirical evaluation using several RDF stream datasets shows that this combination produces gains in compression ratios with respect to using Zlib alone.
The Value of Faculty Internships in Auditing
Year: 2008

Professions such as law, medicine, and engineering have long used faculty internships as a means for educators in these professions to remain current on developments and practices in their respective areas of expertise. Changes in the auditing profession in the last decade have been significant. It is imperative that auditing faculty personally engage in the profession to whatever extent possible to understand how these changes have impacted practice. The purpose of this paper is to describe a faculty internship in auditing and to discuss the benefits of the internship for the academy and the firm.
Sulfated and sialylated N glycans in the echinoderm Holothuria atra reflect its marine habitat and phylogeny
Venue: The Journal of Biological Chemistry
Year: 2020

Among the earliest deuterostomes, the echinoderms are an evolutionary important group of ancient marine animals. Within this phylum, the holothuroids (sea cucumbers) are known to produce a wide range of glycoconjugate biopolymers with apparent benefits to health; therefore, they are of economic and culinary interest throughout the world. Other than their highly modified glycosaminoglycans (e.g. fucosylated chondroitin sulfate and fucoidan) nothing is known about their protein linked glycosylation. Here we used multistep N glycan fractionation to efficiently separate anionic and neutral N glycans before analyzing the N glycans of the black sea cucumber (Holothuria atra) by MS in combination with enzymatic and chemical treatments. These analyses showed the presence of various fucosylated, phosphorylated, sialylated, and multiply sulfated moieties as modifications of oligomannosidic, hybrid, and complex type N glycans. The high degree of sulfation and fucosylation parallels the modifications observed previously on holothuroid glycosaminoglycans. Compatible with its phylogenetic position, H. atra not only expresses vertebrate motifs such as sulfo and sialyl Lewis A epitopes but displays a high degree of anionic substitution of its glycans, as observed in other marine invertebrates. Thus, as for other echinoderms, the phylum and order specific aspects of this species' N glycosylation reveal both invertebrate and vertebrate like features.
Nonvolatile electrically reconfigurable integrated photonic switch
Year: 2019

Reconfigurability of photonic integrated circuits (PICs) has become increasingly important due to the growing demands for electronic photonic systems on a chip driven by emerging applications, including neuromorphic computing, quantum information, and microwave photonics. Success in these fields usually requires highly scalable photonic switching units as essential building blocks. Current photonic switches, however, mainly rely on materials with weak, volatile thermo optic or electro optic modulation effects, resulting in a large footprint and high energy consumption. As a promising alternative, chalcogenide phase change materials (PCMs) exhibit strong modulation in a static, self holding fashion. Here, we demonstrate nonvolatile electrically reconfigurable photonic switches using PCM clad silicon waveguides and microring resonators that are intrinsically compact and energy efficient. With phase transitions actuated by in situ silicon PIN heaters, near zero additional loss and reversible switching with high endurance are obtained in a complementary metal oxide semiconductor (CMOS) compatible process. Our work can potentially enable very large scale general purpose programmable integrated photonic processors.
Genetic Improvement ICSE 2020
Venue: ACM SIGSOFT Softw. Eng. Notes
Year: 2020

Following Prof. Mark Harman of Facebook's keynote and formal presentations (which are recorded in the proceed ings) there was a wide ranging discussion at the eighth inter national Genetic Improvement workshop, GI 2020 ICSE (held as part of the International Conference on Software En gineering on Friday 3rd July 2020) Topics included industry take up, human factors, explainabiloity (explainability, jus tifyability, exploitability) and GI benchmarks. We also con trast various recent online approaches (e.g. SBST 2020) to holding virtual computer science conferences and workshops via the WWW on the Internet without face to face interac tion. Finally we speculate on how the Coronavirus Covid 19 Pandemic will a ect research next year and into the future.
The NS1 protein of avian influenza virus H9N2 induces oxidative stress mediated chicken oviduct epithelial cells apoptosis.
Venue: The Journal of general virology
Year: 2016

The pathogenesis of H9N2 subtype avian influenza virus infection (AIV) in hens is often related to oviduct tissue damage. The viral non structural NS1 protein is thought to play a key role in regulating the pathogenicity of AIV, but its exact function in this process remains elusive. In this study, the pro apoptosis effect of H9N2 NS1 protein was examined on chicken oviduct epithelial cells (COECs) and our data indicated that NS1 induced oxidative stress was a contributing factor in apoptosis. Our data indicate that NS1 protein level was correlated with reactive oxygen species (ROS) in COECs transfected with NS1 expression plasmids. Interestingly, decreased activities of antioxidant enzymes, superoxide dismutase and catalase, were observed in NS1 transfected COECs. Treatment of COECs with antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N acetylcysteine (NAC) significantly inhibited NS1 induced apoptosis. Moreover, although antioxidant treatment has little effect on the activation of caspase 8 in NS1 transfected cells, the activation of caspase 3/9 and Bax/Bcl 2 were significantly downregulated. Taken together, the results of our study demonstrated that expression of H9N2 NS1 alone is sufficient to trigger oxidative stress in COECs. Additionally, NS1 protein can induce cellular apoptosis via activating ROS accumulation and mitochondria mediated apoptotic signalling in COECs.
De l'obligation de redaction des documents de travail en francais
Year: 2014

La loi TOUBON du 4 aout 1994 prevoit l'obligation d'emploi de la langue francais pour differentes informations fournies aux salaries (Loi du 4 aout 1994 relative a l'emploi de la langue francaise, ndeg 94 665, JORF du 5 aout 1994, ndeg 180, p. 11392) De meme, l'employeur ne peut pas se prevaloir a l'encontre d'un salarie de clauses d'un contrat conclu en violation des dispositions de l'article L. 1221 3 du Code du travail. Le contrat de travail, comme les documents contractuels, constituent les fondements de la relation de travail. Ils doivent donc etre compris par le salarie. C'est sur ce point que revient la cour d'appel de Lyon dans l'arret commente.
Integrated supply demand energy management for optimal design of off grid hybrid renewable energy systems for residential electrification in arid climates
Year: 2020

The growing research interest in hybrid renewable energy systems (HRESs) has been regarded as a natural and yet critical response to address the challenge of rural electrification. Based on a Bibliometric analysis performed by authors, it was concluded that most studies simply adopted supply side management techniques to perform the design optimization of such a renewable energy system. To further advance those studies, this paper presents a novel approach by integrating demand supply management (DSM) with particle swarm optimization and applying it to optimally design an off grid hybrid PV solar diesel battery system for the electrification of residential buildings in arid environments, using a typical dwelling in Adrar, Algeria, as a case study. The proposed HRES is first modelled by an in house MATLAB code based on a multi agent system concept and then optimized by minimizing the total net present cost (TNPC) subject to reliability level and renewable energy penetration. After validation against the HOMER software, further techno economic analyses including sensitivity study are undertaken, considering different battery technologies. By integrating the proposed DSM, the results have shown the following improvements: with RF 100% the energy demand and TNPC are reduced by 7% and 18% respectively, compared to the case of using solely supply side management. It is found that PV Li ion represents the best configuration, with TNPC of $23,427 and cost of energy (COE) of 0.23 /kWh. However, with lower RF values, the following reductions are achieved: energy consumption (19% and fuel consumption or CO2 emission (57% respectively. In contrast, the RF is raised from 15% (without DSM) to 63% (with DSM) It is clear that the optimal configuration consists of wind diesel, with COE of 0.21 /kWh, smaller than that obtained with a stand alone diesel generator system. The outcomes of this work can provide valuable insights into the successful design and deployment of HRES in Algeria and surrounding regions.
Taphonomic process versus usewears in the formation of macroscopic traces. An experimental assesment
Year: 2017

Since many decades, the caracterisation of lithic tools that might be used by prehistoric societies is based on the presence of retouch on their active parts. Thereby, typo technological and then functional analysis were initially interested in retouched tools unmodified tools were considered as remains of the lithic production, as roughout or technical products Recently, lithics functional analysis have proved the common use of unretouched edges of retouched tools and even the use of unmodified tools, especially in case of domestic activities, from final Palaeolithic to Neolitic. These unmodified tools are firstly identified by traceologist thanks to the presence of edge damages, as chips, on their active parts. Researchers are therefor confronted to the difficulty in distinguishing usewears from accidental wears which may be due to trampling, for exemple. This is even more true when it comes to tools used briefly on soft materials, often relative to an expedient production, especially in the Mesolithic. It is the reason why these kind of industry have been ignored by researchers for a long time. But these tools, frequently used for domestic activities, are still a key to better understand the way of life of these prehistoric societies. This poster will present experimentations made since 2015 two experimentations of butchering on horses and deers made with 85 tools and an experimentation of trempling made with 51 tools, all unretouched. Wears due to these different process are compared by macroscopic and microscopic observations, from x10 to x200. Results are part of a Phd research on lithic traceology interested in the function of unretouched tools from Mesolithic to early Neolithic in south of France. The objective is to propose new standards and criteria to distinguish taphonomic wears from usewears, in order to better recognize the use of unretouched tools by prehistoric societies.