nils-herrmann/clean_scirepeval huggingface dataset:
Association between serum periostin concentrations and outcome after acute spontaneous intracerebral hemorrhage.
Venue: Clinica chimica acta; international journal of clinical chemistry
Year: 2017

Higher serum periostin concentrations are associated with mortality after head trauma. We further determined the relationship between periostin concentrations, severity, and clinical outcome in patients with intracerebral hemorrhage (ICH) METHODS We prospectively included 128 controls and 128 consecutive patients with acute ICH within the first 24h after onset. At admission, we measured serum periostin concentrations.  Serum periostin concentrations were significantly higher in the patients than in the controls. Serum periostin concentrations were positively related to National Institutes of Health Stroke Scale (NIHSS) score (r=0.526) and hematoma volume (r=0.586) An unfavorable outcome (defined as modified Rankin scale >2) was observed in 65 (50.8% patients. Serum periostin [odds ratio (OR) 1.008; 95% confidence interval (CI) 1.002 1.013] NIHSS score (OR, 1.462; 95% CI, 1.209 1.767) hematoma volume (OR, 1.134; 95% CI, 1.047 1.227) and age (OR, 1.060; 95% CI, 1.015 1.108) emerged as independent predictors for 6 month unfavorable outcome. In terms of ROC AUC, serum periostin concentrations had significantly higher predictive value compared with age and showed similar predictive value compared with NIHSS score and hematoma volume.  High concentrations of serum periostin in acute ICH patients are associated with increasing severity and a poor functional prognosis.
Acute Hepatocellular Jaundice After Dofetilide Initiation: A Case Report
Venue: Hospital pharmacy
Year: 2018

Dofetilide's hepatotoxicity is not well described. In this case report, we describe acute hepatocellular jaundice related to dofetilide use in a 33 year old male being treated for atrial fibrillation. Both viral and ischemic causes of hepatocellular damage were ruled out as unlikely in this case. This case report outlines a rare yet probable report of idiosyncratic dofetilide induced liver injury.
Design for Health 4.0: Exploration of a New Area
Venue: Proceedings of the Design Society: International Conference on Engineering Design
Year: 2019

Driven by networked Electronic Health Record systems, Artificial Intelligence, real time data from wearable devices with an overlay of invisible user interfaces and improved analytics, Health 4.0 is changing the healthcare industry. The focus on collaboration, coherence, and convergence that will make healthcare more predictive and personalised. Furthermore, Health 4.0 realises the value of data more consistently and effectively. It can pinpoint areas of improvement and enable more informed decisions. What it also does is help move the entire healthcare industry from a system that is reactive and focused on fee for service to a system that is value based, which measures outcomes and ensures proactive prevention.In this paper, the authors will first explore the realm of the emerging area of Health 4.0 and identify its opportunities and challenges. This includes understanding the relevant base technologies as well as the design principles for the realization of smart healthcare product, systems and product service systems of the future. Following on from there, the authors focus on the role of design in the specific context of healthcare.
Research on the ploughing force in micro milling of soft brittle crystals
Venue: International Journal of Mechanical Sciences
Year: 2019

The ploughing force can be assigned to supervisory control of the tool wearing and machining process on line in micro milling, for the reason that the ploughing force is closely related with the processed surface quality and radius of cutting edge. A new theoretical model is established to determine the ploughing force in micro milling of crystals with soft brittle characters in consideration of the cutting edge roundness, and it is verified by Finite Element Method. The ploughing force decreases quickly with an decrease of the cutting edge roundness, and it can be controlled to be less than the shearing force, which helps for obtaining a good machined surface quality, under the condition that the radius of cutting edge is less than 2.8 mm or the feed speed is larger than 5 mm/z when the radius of cutting edge is larger than 4.2 mm. Meanwhile, a large feed speed would bring heavy tool traces on the processed surface of soft brittle crystals, destroying the processed quality. The energy consumption is researched by investigating the specific cutting force, showing that the energy consumption has a sharp increase with a small feed speed. The energy consumption is mainly caused by the ploughing effect, especially for tools with blunt cutting edge. Therefore, both the micro mill with sharp tool edge or blunt tool edge (under the cutting condition that the feed speed almost have equal value to the radius of cutting edge) are highly recommended for micro end milling of soft brittle crystals.
Research Status of Marine Drag Reduction Technologies
Year: 2015

Navigation objects in the water, such as ship, submarine and torpedo play important roles in the ocean economic development and defense. Traveling speed and energy consumption are significant parameters which determine the operating performance of navigation objects. Utilizing drag reduction technologies to reduce the water resistance to navigation objects is of great significance. This article classifies and summarizes some important marine drag reduction technologies by drag reducing mechanism,and has a brief description of their research status and drag reduction mechanisms, including the bionic,microbubble and hydrophobic /super hydrophobic coating. Based on the existing summary and analysis of marine drag reduction technologies, their future research priorities are also prospected.
COVID 19 vaccine development: Time to consider SARS CoV 2 challenge studies?
Venue: Vaccine
Year: 2020

While a human challenge study holds the prospect of accelerating the development of a vaccine for the coronavirus SARS CoV 2, it may be opposed due to risks of harm to participants and researchers. Given the increasing number of human deaths and severe disruption to lives worldwide, we argue that a SARS CoV 2 challenge study is ethically justifiable as its social value substantially outweighs the risks. Such a study should therefore be seriously considered as part of the global research response towards the COVID 19 pandemic. In this paper, we contribute to the debate by addressing the misperception that a challenge study for the coronavirus would lower scientific and ethical standards for vaccine research and development, and examine how it could be ethically conducted. We also set out information that needs to be disclosed to prospective participants to obtain their consent.
Diagnostika i likuvannia psikhichnikh rozladiv u konteksti dikhotomiyi <priroda vikhovannia> (Diagnosis and Treatment of Mental Disorders in the Context Of 'Nature Nurture' Dichotomy)
Year: 2017

Skladna bagatogranna sutnist' liudini iak biologichnogo, psikhologichnogo, sotsial'nogo buttia privertala do sebe uvagu doslidnikiv i viklikala gariachi debati protiagom bagat'okh stolit' Z'iasuvannia fenomenu liudini, yiyi prirodi i sutnosti ie vkrai neobkhidnim dlia takoyi galuzi klinichnoyi meditsini iak psikhiatriia. S'ogodni isnuie masshtabna problema diagnostuvannia ta likuvannia psikhichnikh rozladiv. Adekvatni metodi diagnostiki ta likuvannia v konteksti problemi <priroda vs vikhovannia> viklikaiut' naukovi superechki, shcho tochat'sia mizh spetsialistami u vidpovidnikh galuziakh. U statti zrobleno sprobu proanalizuvati rizni pidkhodi do psikhichnikh rozladiv, a takozh spetsifichnikh i nespetsifichnikh metodiv likuvannia English Abstract: The complex multifaceted essence of human as a biological, psychological, social being has attracted the attention of researchers and has caused hot debates during centuries. The deep understanding of the phenomenon of human being, his/her nature and essence is critical for the field of clinical medicine such as psychiatry. Nowadays, diagnosis and treatment of mental disorders are the acute problems. Appropriate methods of diagnosis and treatment in the context of "nature vs nurture" dichotomy cause scientific disputes between experts in the relevant fields. The paper attempts to analyze different approaches to mental disorders, as well as specific and non specific treatment.
Unconstrained genome targeting with near PAMless engineered CRISPR Cas9 variants
Venue: Science
Year: 2020

A PAMless base editor CRISPR Cas DNA base editing typically requires a specific motif for targeting known as a protospacer adjacent motif (PAM) This requirement limits the sequences within a genome that can be targeted. Walton et al. engineered specific variants of the Streptococcus pyogenes Cas9 enzyme named SpG and SpRY that could recognize and edit a wider array of PAMs. Using SpRY, the authors were able to correct previously uneditable mutations associated with human disease. Although off target effects were observed for these engineered Cas enzymes at levels similar to those of the wild type enzyme, depending on the context, these engineered enzymes widen the potential applications of precision genome editing. Science, this issue p. 290 Engineered Cas variants nearly eliminate the protospacer adjacent motif requirement for DNA targeting CRISPR enzymes. Manipulation of DNA by CRISPR Cas enzymes requires the recognition of a protospacer adjacent motif (PAM) limiting target site recognition to a subset of sequences. To remove this constraint, we engineered variants of Streptococcus pyogenes Cas9 (SpCas9) to eliminate the NGG PAM requirement. We developed a variant named SpG that is capable of targeting an expanded set of NGN PAMs, and we further optimized this enzyme to develop a near PAMless SpCas9 variant named SpRY (NRN and to a lesser extent NYN PAMs) SpRY nuclease and base editor variants can target almost all PAMs, exhibiting robust activities on a wide range of sites with NRN PAMs in human cells and lower but substantial activity on those with NYN PAMs. Using SpG and SpRY, we generated previously inaccessible disease relevant genetic variants, supporting the utility of high resolution targeting across genome editing applications.
PARODIA E DESSACRALIZACAO EM O EVANGELHO SEGUNDO JESUS CRISTO E CAIM, DE JOSE SARAMAGO
Year: 2020

Referencia na narrativa portuguesa contemporanea e contemplado por premios como Camoes (1995) e o Nobel de Literatura (1998)  (1922 2010) traz em suas obras criticas a diversos temas, como a religiao Crista, o abuso de poder, a misoginia, entre outros tantos. Dado o contexto do fenomeno da secularizacao ocidental no seculo XX, no qual o declinio do prestigio a religiao se manifesta nas criacoes artisticas e literarias, Saramago elabora sua critica a religiao crista e a figura de Deus fazendo uso da ironia, escrevendo O Evangelho segundo Jesus Cristo (1991) e Caim (2009) parodias da Biblia Sagrada que recontam a historia dos textos sacros de maneira humanizada, o que resulta na dessacralizacao das entidades e personagens sacras do texto canonico. Tal dessacralizacao possui teor critico, que, acompanhado da ironia, e elemento fundamental da parodia. Assim, busca se neste artigo evidenciar a distanciacao parodica e a dessacralizacao nos textos de Saramago, analisando os tracos parodicos com base em Linda Hutcheon (1985) e ironicos com base em Beth Brait (2009) que por sua vez, se baseia em Bakhtin (1963) comparando o processo de transformacao das personagens protagonistas que levam o leitor ao pensamento critico acerca da figura divina eternizada pela cultura crista.
Evaluation and Sequential Dispatch of Operating Reserve Provided by Air Conditioners Considering Lead Lag Rebound Effect
Venue: IEEE Transactions on Power Systems
Year: 2018

Air conditioners (ACs) are widely considered as good candidates to provide operating reserve. Demand response rebound, i.e. the rebound peak of aggregate power, may exist when ACs are controlled by changing the set point temperature. The rebound peak during the recovery period, named lag rebound, may cause significantly higher demand than that prior to the reserve deployment event. The rebound peak during the reserve deployment period, named lead rebound, is rarely considered in previous researches but will constrain the duration time to a short period (e.g. 10 min) which greatly limits the utilization of ACs. This paper proposes an optimal sequential dispatch strategy of ACs to mitigate the lead lag rebound, and thus realize flexible control of the duration time from minutes to several hours. To quantify the effects of lead lag rebound, a capacity time evaluation framework of the operating reserve is developed. On this basis, ACs are grouped to be dispatched in sequence to mitigate the lead lag rebound. The co optimization of sequential dispatch on the capacity dimension and time dimension forms a mixed integer nonlinear bilevel programming problem, in which the consumers' thermal comfort is also guaranteed. Case studies are conducted to validate the proposed strategy.
Molecular simulations on nanoconfined water molecule behaviors for nanoporous material applications
Year: 2013

Nanoporous materials applications have been increasingly applied in energy and environmental fields. Nanoconfined water behaviors play important roles in the application of nanoporous materials and molecular simulation is an effective approach to investigate these roles. We reviewed the selected related works and the recent research progress of our group to understand what indeed we can learn from molecular simulations of nanoconfined water molecule behaviors and how these understandings could promote the nanoporous material applications. This review is organized into two parts. First, the understanding of nanoconfined water molecule behaviors in biology using molecular simulation sets up the performance benchmarks for designing nanoporous materials. Second, molecular simulation studies in carbon nanotubes reveal useful structure property relationships of confined water molecules for the preparation and applications of carbon nanotube membranes in flux and selectivity. This review shows that roles of molecular simulation studies are to discover the key factor at the nanoscale which is usually ignored, and to provide an understanding that will break the conventional view of nanoporous material design and application. The difficulties in the present study are also discussed.
Multi Person Pose Estimation with Attention
Venue: 2020 International Conference on Information Networking (ICOIN)
Year: 2020

The existing pose estimation networks extract confidence maps and Part Affinity Fields (PAFs) from all pixels in images. However, we found that the recognition rate can be decreased due to the background. This limitation arises from the process to extract feature maps from the image. To overcome this limitation, we adopt the attention block in front of the backbone network. To show that our proposed network can reduce the error and increase the precision, we compared PCKh and mAP with the existing pose estimation network.
Endoplasmic reticulum stress plays a central role in development of leptin resistance.
Venue: Cell metabolism
Year: 2009

Leptin has not evolved as a therapeutic modality for the treatment of obesity due to the prevalence of leptin resistance in a majority of the obese population. Nevertheless, the molecular mechanisms of leptin resistance remain poorly understood. Here, we show that increased endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) in the hypothalamus of obese mice inhibits leptin receptor signaling. The genetic imposition of reduced ER capacity in mice results in severe leptin resistance and leads to a significant augmentation of obesity on a high fat diet. Moreover, we show that chemical chaperones, 4 phenyl butyric acid (PBA) and tauroursodeoxycholic acid (TUDCA) which have the ability to decrease ER stress, act as leptin sensitizing agents. Taken together, our results may provide the basis for a novel treatment of obesity.
Investigation of traffic and safety behavior of pedestrians while texting or web surfing
Venue: Traffic injury prevention
Year: 2020

More and more pedestrians use mobile phones in their daily traffic activities by the roadside or even when crossing the street. The objective of this research is to examine pedestrians' traffic and safety behavior while texting or web surfing, when crossing signalized intersections.  In order to compare the behavior of distracted and non distracted pedestrians, an experimental process through video recording was carried out in real road conditions, in three signalized intersections in the center of Athens in Greece. Demographic and behavioral characteristics were observed, including use of mobile device. For the statistical analysis, two multiple linear regression models were developed to investigate the association of pedestrians' speed and distraction caused by mobile phone use. Additionally, binary logistic regression models were developed in order to determine the influence of distraction on pedestrians' safety characteristics and more specifically on near misses with oncoming vehicles.  Observers recorded crossing behaviors for 2,280 pedestrians and noticed that nearly one fifth (16.6% of them performed a phone distracting activity while crossing. Distractions included texting or web surfing (6.3% listening to music (5.4% and using a handheld phone (4.9% This research indicated that distraction caused by texting or web surfing had a negative impact on pedestrians' main traffic and safety characteristics. Results pointed out that in high pedestrian traffic, distracted pedestrians who were texting or web surfing on their mobile phone present lower speed than non distracted pedestrians, regardless of their age, as they may be not aware of traffic conditions due to distraction and therefore, they have higher crossing times. Furthermore, their probability of a near miss increases with increasing pedestrian volume as the more pedestrians who occupy the pedestrian crossing the more difficult is for them to observe carefully the rest traffic.  Mobile phones are integral to contemporary daily life and their use and penetration is increasing rapidly as well. For this reason, it is crucial to investigate the impacts of distracted walking on pedestrians' traffic and safety behavior. Various measures and strategies should be implemented and further research should be conducted as texting and web surfing distraction is associated with a rather high risk.
Unmet adolescent and young adult cancer survivors information and service needs: a population based cancer registry study
Venue: Journal of Cancer Survivorship
Year: 2012

PurposeWe described unmet information and service needs of adolescent and young adult (AYA) cancer survivors (15 39 years of age) and identified sociodemographic and health related factors associated with these unmet needs.MethodsWe studied 523 AYAs recruited from seven population based cancer registries, diagnosed with acute lymphocytic leukemia, Hodgkin's lymphoma, non Hodgkin's lymphoma, germ cell cancer, or sarcoma in 2007 2008. Participants completed surveys a median of 11 months from diagnosis. Multivariable logistic regression analyses were used to estimate associations between unmet (information and service) needs and sociodemographic and health related factors.ResultsMore than half of AYAs had unmet information needs relating to their cancer returning and cancer treatments. AYAs needing services, but not receiving them, ranged from 29 for in home nursing to 75 for a support group. The majority of AYAs who needed a pain management expert, physical/occupational therapist, mental health worker, or financial advice on paying for health care did not receive services. In multivariable analyses, older participants, men, participants of non white race/ethnicity, and participants who reported less than excellent general health or fair/poor quality of care were more likely to report unmet information needs. Factors associated with both unmet service and information needs included physical health or emotional problems interfering with social activities or having =3 physical treatment related symptoms.ConclusionsRecently diagnosed AYA cancer survivors have substantial unmet information needs varying by demographic and health related factors.Implications for cancer survivorsWe identified subgroups of AYA cancer survivors with high unmet needs that can be targeted for interventions and referrals.
Sedentary behavior, exercise and COVID 19: immune and metabolic implications in obesity and its comorbidities.
Venue: The Journal of sports medicine and physical fitness
Year: 2020

Many reports showed a dramatic decrease in the levels of physical activity during the current pandemic of SARS COV 2. This has substantial immune and metabolic implications, especially in those at risk or with metabolic diseases including individuals with obesity and Type 2 diabetes. Here we discuss the route from physical inactivity to immune and metabolic aberrancies; focusing on how insulin resistance could represent an adaptive mechanism to the low physical activity levels and on how such an adaptive mechanism could shift to a pathognomonic feature of metabolic diseases, creating a vicious circle of immune and metabolic aberrancies. We provide a theoretical framework to the severe immunopathology of COVID 19 in patients with metabolic diseases. We finally discuss the idea of exercise as a potential adjuvant against COVID 19 and emphasize how even interrupting prolonged periods of sitting with short time breaks of very light activity could be a feasible strategy to limit the deleterious effects of the outbreak.