nils-herrmann/clean_scirepeval huggingface dataset:
Dynamic assessment of internal carotid artery and elongated styloid process in a case of bilateral carotid artery dissection
Venue: Surgical neurology international
Year: 2020

Vascular Eagle syndrome is that an elongated styloid process causes ischemic stroke due to internal carotid artery (ICA) dissection. Dynamic assessment using radiological imaging has not been well investigated. We assessed the change in the relative positional relationship between the elongated styloid process and the ICA using a cone beam computed tomography (CBCT)  A 46 year old female presenting with disturbance of consciousness, right hemiparesis, and aphasia was admitted to our hospital. Initial CT analysis showed a bilateral elongated styloid process. Magnetic resonance angiography (MRA) showed occlusion of the left ICA and a near occlusion of the right ICA. MRA also revealed the intimal flap and intramural hematoma in the bilateral ICA. Digital subtraction angiography showed bilateral ICA occlusion and carotid artery stenting was performed subsequently. After that, we visualized the movement of carotid stent with CBCT fusion methods. The stent moved forward and backward at the attachment point of the styloid process during head rotation, and there was a possibility that mechanical stress was emphasized at this point. Styloidectomy was performed after her rehabilitation. The patient did not experience a recurrence of stroke.  We showed that repeated attachment of the styloid process and ICA may trigger an ICA dissection during head rotation. This finding would be helpful for understanding the causes of vascular Eagle syndrome.
The Role of Innovative Communication Channels, Effective Coordination Strategy and Knowledge Management in the UK Local Government Planning System
Venue: J. Inf. Knowl. Manag.
Year: 2013

This research is an exploratory study of innovative communication channels, effective coordination strategy and integrated knowledge management in the UK local government planning system. The UK local government planning system at present suffers delays, which slow down or prevent people building new homes, creating new facilities and bringing disused or neglected land and buildings back into productive use. This study has been carried out in the subject area to explore enhanced efficiency and effectiveness in the UK local government planning system. An integrated knowledge based planning system is considered as an appropriate solution to achieve smart and sustainable development in the local government planning system. This research study is based primarily upon fieldwork conducted in five participating local authorities in the South East Midlands (Bedford Borough Council, Central Bedfordshire Council, Luton Borough Council, Milton Keynes Council and Northampton Borough Council) and on literature drawn from many different disciplines. A mixed methods approach is chosen for the research fieldwork. The key data collection methods applied during the fieldwork include: structured questionnaires, semi structured interviews, online group forums, email correspondence, prearranged observations, literature review, document analysis and reviews of the local government publications and their statistical reports. The key purpose of this study is to investigate how the planning system in the UK local government can be transformed from its current "As Is" state towards a smart and sustainable development future "To Be" state.
Nonlinearities and the Sustainability of the Government's Intertemporal Budget Constraint
Year: 2012

We analyze the sustainability of the government's intertemporal budget constraint and the corresponding fiscal reaction function within a nonlinear error correction framework. Our empirical analysis, based on Italy, provides some evidence that the Italian government is meeting its intertemporal budget constraint. Nevertheless, we show that the burden of correcting budgetary disequilibria is entirely carried out by changes in the average tax rate, with a weakly exogenous government spending, possibly determined by the political process. We also document some rigidities of the tax instrument, in terms of downward inflexibility of the average tax rate with respect to its long run level. Finally, we provide some evidence in favor of a nonlinear adjustment toward a sustainable long run equilibrium, as the average tax rate adjusts faster the further away it gets from the equilibrium. By considering the behavior of taxes across the economic cycle, we also provide some evidence of inflexibility of the tax instrument during bad times.
Recovering Supply Chain Disruptions in Post COVID 19 Pandemic Through Transport Intelligence and Logistics Systems: India's Experiences and Policy Options
Venue: Frontiers in Future Transportation
Year: 2021

Before the COVID 19 pandemic, Indian firms have focused on interconnected and lean supply chains to ameliorate the gaps through increased efficiency of supply chains. However, the pandemic has exposed most Indian firms to severe supply chain disruptions (SCDs) due to undiscovered supply chain vulnerabilities. Against this background, we reviewed the existing relevant literature on SCDs and transportation disruption in general context and pandemic specific context and identified that there exists very little research on this issue especially in the context of Indian firms, and offered policy options by developing a new model of robust transport and advanced logistics system (ALS) for speedier supply chains recovery (SCR) We have utilized and analyzed the rich available literature on SCDs, transport intelligence (TI) and ALS using gray literature. The study revealed that many Indian firms have experienced major disruptions in transportation and logistics services, including impact on transportation and logistics data, time delays, and cargo cancellations due to cramped freight capacity, restricted circulation, closure of ports, and slow customs clearances. This has also impacted adversely the production and transport consignments including logistics services and led to delays and rerouting to final consumers. With the gradual removal of restrictions, firms are making concerted efforts to recover from SCDs; however, with weak applications of robust TI and ALS, the SCR is relatively very slow. This called for a review of current transport and ALS used by priority firms. Therefore, we offered a new model for addressing the SCDs using robust intelligence transportation systems and ALS.
Implementation of ecovillage values model as Mandiri village and environmental culture in the community of Sukasari Kidul village district of Argapura, regency of Majalengka
Venue: Journal of Physics: Conference Series
Year: 2019

Daily human life on the face of the earth is influenced and affects the surrounding environment. Sometimes people feel free to live and apart from the support of the surrounding environment. Therefore, it is appropriate for us in our daily lives to need to maintain and manage the environment. Especially in various development programs that have the main goal of increasing the level of human welfare that needs to be supported by economic capital, social capital and natural capital as well as the environment or ecosystem. Development can be seen as planned efforts to change human culture. Changes in the social system of local communities can also cause changes to the ecosystem. The ecovillage concept aims to change the mindset of society in changing behavior to be more concerned about the environment. The potential possessed by Sukasari Kidul Village is agricultural and plantation products.
Multi objective optimization design for a battery pack of electric vehicle with surrogate models
Year: 2016

In this investigation, a systematic surrogate based optimization design framework for a battery pack is presented. An air cooling battery pack equipped on electric vehicles is first designed. Finite element analysis (FEA) results of the baseline design show that global maximum stresses under x axis and y axis transient acceleration shock condition are both above the tensile limit of material. Selecting the panel and beam thickness of battery pack as design variables, with global maximum stress constraints in shock cases, a multi objective optimization problem is implemented using metamodel technique and multi objective particle swarm optimization (MOPSO) algorithm to simultaneously minimize the total mass and maximize the restrained basic frequency. It is found that 2nd order polynomial response surface (PRS) 3rd order PRS and radial basis function (RBF) are the most accurate and appropriate metamodels for restrained basic frequency, global maximum stresses under x axis and y axis shock conditions respectively. Results demonstrate that all the optimal solutions in Pareto Frontier have heavier weight and lower frequency compared with baseline design due to the restriction of global maximum stress response. Finally, two optimal schemes, "Knee Point" and "lightest weight" satisfied both of the stress constraint conditions, show great consistency with FEA results and can be selected as alternative improved schemes.
Clash of the Titans: Temporal Organizing and Collaborative Dynamics in the Panama Canal Megaproject
Year: 2016

Recent studies of temporary organizing and project based work explain how organizational actors establish and maintain clear role structures and harmonious relations in the face of precariousness by engaging in stabilizing work practices. This focus upon 'order' undervalues conflict ridden negotiations and power struggles in temporary organizing. This paper demonstrates that in temporary organizing conflict and order may exist in tandem. Drawing close to the collaborative dynamics in a large scale global project, we analyse the political struggles over role patterns and hierarchic positioning of client and agent in the temporary organization of the Panama Canal Expansion Program (PCEP) In such projects, the agent typically takes the position of project leader. In this case however, the client was formally in charge, while the agent was assigned the role of coach and mentor. The diffuse hierarchy triggered project partners to engage in both harmony seeking social and discursive practices and to enter into conflict ridden negotiations over authority relations in the everyday execution of the PCEP project. Our study contributes to existing literatures on temporal organizing by presenting a case of simultaneous practices of harmonization and contestation over mutual roles and hierarchic positions. We also show that studying collaboration between project partners involves, not merely analysing project governance structures, but also offering a context sensitive account of everyday social and discursive practices. Finally, we reflect on a view of 'permanence' and 'temporariness' as themselves contested categories and symbolic sites for struggle.
Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents.
Venue: Digestive and liver disease official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Year: 2019

Nonalcoholic fatty liver disease (NAFLD) is the commonest liver disease in children and adolescents in Western countries. Complex traits arise from the interplay between environmental and genetic factors in the pathogenesis of NAFLD.  We examined the association between NAFLD and eleven single nucleotide polymorphisms (SNPs) at genetic loci potentially associated with liver damage (GCKR, MBOAT7, GPR120) oxidative stress (SOD2) lipid metabolism (PNPLA3, TM6SF2, LPIN1, ELOVL2, FADS2, MTTP) and fibrogenesis (KLF6) in a paediatric population. A genetic risk score (GRS) was performed taking into account both these SNPs and clinical risk factors.  We recruited a cohort of 514 obese children and adolescents (mean age SD] 11.2 2.8 years, z BMI 3.3 0.8) NAFLD was identified by ultrasonography. Genotyping was performed by TaqMan based RT PCR system.  The overall prevalence of NAFLD was 67.5% (347 patients) Among the eleven genotyped SNPs, the genetic variants in TM6SF2 rs58542926 (OR 4.13, p 0.002) GCKR rs1260326 (OR 1.53, p 0.003) PNPLA3 rs738409 (OR 1.58, p 0.004) and ELOVL2 rs2236212 (OR 1.34, p 0.047) were significantly associated with a higher risk of NAFLD. Addition of a 11 polymorphism GRS to established clinical risk factors significantly (albeit modestly) improved the discriminatory capability of the regression model for predicting the risk of NAFLD (with SNPs C statistic 0.81 [95%CI 0.75 0.88] vs. 0.77 [0.70 0.84] without SNPs; p 0.047) CONCLUSIONS NAFLD was strongly associated with three genetic variants, TM6SF2 rs58542926, PNPLA3 rs738409 and GCKR rs1260326, and more slightly with ELOVL2 rs2236212, in obese children and adolescents. Addition of a 11 polymorphism GRS to clinical risk factors improved the predictability of NAFLD.
Optimal Approach to Lobectomy for Non Small Cell Lung Cancer: Systemic Review and Meta Analysis
Venue: Innovations
Year: 2019

Video assisted thoracic surgery (VATS) lobectomy was introduced over 25 years ago. More recently, the technique has been modified from a multiport video assisted thoracic surgery (mVATS) to uniportal (uVATS) and robotic (rVATS) with proponents for each approach. Additionally most lobectomies are still performed using an open approach. We sought to provide evidence based recommendations to help define the optimal surgical approach to lobectomy for early stage non small cell lung cancer.  Systematic review and meta analysis of articles searched without limits from January 2000 to January 2018 comparing open, mVATS, uVATS, and rVATS using sources Medline, Embase, and Cochrane Library were considered for inclusion. Articles were individually scrutinized by ISMICS consensus conference members, and evidence based statements were created and consensus processes were used to determine the ensuing recommendations. The ACC/AHA Clinical Practice Guideline Recommendation Classification system was used to assess the overall quality of evidence and the strength of recommendations. Results and recommendations One hundred and forty five studies met the predefined inclusion criteria and were included in the meta analysis. Comparisons were analyzed between VATS and open, and between different VATS approaches looking at oncological outcomes (survival, recurrence, lymph node evaluation) safety (adverse events) function (pain, quality of life, pulmonary function) and cost effectiveness. Fifteen statements addressing these areas achieved consensus. The highest level of evidence suggested that mVATS is preferable to open lobectomy with lower adverse events (36% versus 42% 88,460 patients) and less pain (IIa recommendation) Our meta analysis suggested that overall survival was better (IIb) with mVATS compared with open (71.5% versus 66.7% 5 years; 16,200 patients) Different VATS approaches were similar for most outcomes, although uVATS may be associated with less pain and analgesic requirements (IIb)  This meta analysis supports the role of VATS lobectomy for non small cell lung cancer. Apart from potentially less pain and analgesic requirement with uVATS, different minimally invasive surgical approaches appear to have similar outcomes.
LEADERSHIP STYLES OF NURSE MANAGERS AND THEIR EFFECTS ON NURSE AND ORGANISATIONAL PERFORMANCE ISSUES AND PROBLEMS
Year: 2017

The aim of this review was to evaluate the effect of leadership styles of nurse managers on nurse and organisational performances and identify the research gaps. The literature search using Google Scholar yielded 53 articles on the entire range of the topic. Although nurses play a vital role, their performance can be significantly affected by the leadership style of the nurse manager under whom they work. Both positive and negative effects are possible. Negative effects may lead to errors in patient care, delayed or poor service delivery and even leaving the organisation. The nurse has no job satisfaction. High turnover of nurses, poor enrolment in nursing schools, financial loss to the hospital for orienting the new nurses and loss of reputation if there is high turnover rate and their impact on patient care are serious issues. Increasing trend of medical errors demonstrate the importance of providing the right work environment and empowerment to the nurses and good leadership by nurse managers for their motivation and high level of performance. Research gaps related to eight issues and problems were identified from the review.
Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor like Protein 2 (APLP2)
Venue: The Journal of Biological Chemistry
Year: 2013

PCSK9 functions to degrade the LDLR by a previously unknown lysosomal sorting mechanism.  Here, we discovered and characterized a novel, pH dependent interaction between PCSK9 and the amyloid precursor like protein 2 (APLP2)  APLP2 plays an integral role in postendocytic PCSK9 lysosomal sorting.  These findings provide key insights into the mechanism by which PCSK9 degrades LDLR and reveal a novel lysosomal transport complex. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates low density lipoprotein receptor protein levels by diverting it to lysosomes. Monoclonal antibody therapeutics aimed to neutralize PCSK9 have been shown to successfully lower serum LDL levels; however, we previously found that such therapeutic antibodies are subject to PCSK9 mediated clearance. In this study, we discovered that PCSK9 interacts via its C terminal domain directly and in a pH dependent manner with amyloid precursor protein as well as its closely related family member, amyloid precursor protein like protein 2. Furthermore, we determined that amyloid precursor protein like protein 2, but not amyloid precursor protein, is involved in mediating postendocytic delivery of PCSK9 to lysosomes and is therefore important for PCSK9 function. Based on our data, we propose a model for a lysosomal transport complex by which a soluble protein can target another protein for degradation from the luminal side of the membrane by bridging it to a lysosomally targeted transmembrane protein.
Prevalence and co infection of Malaria and Typhoid in the local population of Faisalabad, Pakistan.
Venue: Pakistan journal of pharmaceutical sciences
Year: 2019

Malaria and typhoid fever are among the major infectious diseases which impose significant health and socioeconomic burden on affected populations. Further, co infection and resembling symptomatology in both infections, mostly leads to misdiagnosis and mistreatment. So co infection of malaria and typhoid fever is becoming a major issue in tropical and subtropical countries. The current study was planned to explore the rate of co infection of malaria and typhoid fever to show the diagnostic challenges and people health implications in the local population of Faisalabad Pakistan. For this purpose, 144 samples (n=144) were collected from suspected subjects both male (n=74) and female (n=70) (comprises of three age group ranges viz >01 10, 11 20 and above 20 years old) of typhoid fever and malaria from October to December 2017 at Children Hospital, Faisalabad Pakistan. Thick smear as a gold standard technique for malaria diagnosis and Widal agglutination technique for typhoid diagnosis were used. Results revealed that the prevalence of co infection in selected subjects was 6.3% (n=9) with higher prevalence in female subjects (7.1% as compared to males (5.4% Further, it was also reported that age groups >01 10 years old, 11 20 years old and 21 above years old have6.6 (n=75) 5.7 (n=35) and 5.8% (n=34) coinfection prevalence respectively. In the present study, it could be concluded that although the prevalence of co infection of malaria and typhoid fever in the studied population was possible but sensitivity of diagnostic tools was limited, so more reliable, specific and sensitive diagnostic tools are required to report confidently more precise correlation of these infectious diseases.
Registry of the Japanese society of lung and heart lung transplantation: the official Japanese lung transplantation report 2012
Venue: General Thoracic and Cardiovascular Surgery
Year: 2013

The Japanese Organ Transplant Law was amended, and the revised law took effect in July 2010 to overcome extreme donor shortage and to increase the availability of donor organs from brain dead donors. It is now possible to procure organs from children. The year 2011 was the first year that it was possible to examine the results of this first extensive revision of the Japanese Organ Transplant Law, which took effect in 1997. Currently, seven transplant centers, including Tohoku, Dokkyo, Kyoto, Osaka, Okayama, Fukuoka and Nagasaki Universities, are authorized to perform lung transplantation in Japan, and by the end of 2011, a total of 239 lung transplants had been performed. The number of transplants per year and the ratio of brain dead donor transplants increased dramatically after the revision of the Japanese Organ Transplant Law. The survival rates for lung transplant recipients registered with the Japanese Society for Lung and Heart lung Transplantation were 93.3 at 1 month, 91.5 at 3 months, 86.3 at 1 year, 79.0 at 3 years, and 73.1 at 5 years. The survival curves for brain dead donor and living donor lung transplantation were similar. The survival outcomes for both brain dead and living donor lung transplants were better than those reported by the International Society for Heart and Lung Transplantation. However, donor shortage remains a limitation of lung transplantation in Japan. The lung transplant centers in Japan should continue to make a special effort to save critically ill patients waiting for lung transplantation.
Feature Weight Optimization Mechanism for Email Spam Detection based on Two step Clustering Algorithm and Logistic Regression Method
Year: 2017

This research proposed an improved filtering spam technique for suspected emails, messages based on feature weight and the combination of two step clustering and logistic regression algorithm. Unique, important features are used as the optimum input for a hybrid proposed approach. This study adopted a spam detector model based on distance measure and threshold value. The aim of this model was to study and select distinct features for email filtering using feature weight method as dimension reduction. Two step clustering algorithm was used to generate a new feature called "Label" to cluster and differentiate the diversity emails and group them based on the inter samples similarity. Thereby the spam filtering process was simplified using the Logistic regression classifier in order to distinguish the hidden patterns of spam and non spam emails. Experimental design was conducted based on the UCI spam dataset. The outcome of the findings shows that the results of the email filtering are promising compared to other modern spam filtering methods.