nils-herrmann/clean_scirepeval huggingface dataset:
Mesenchymal stromal cell derived exosomes improve pulmonary hypertension through inhibition of pulmonary vascular remodeling
Venue: Respiratory Research
Year: 2020

Pulmonary hypertension (PH) is a life threatening disease characterized by pulmonary vascular remodeling, right ventricular hypertrophy and failure. So far no effective treatment exists for this disease; hence, novel approaches are urgently needed. The aim of the present research was to observe the treatment effect of mesenchymal stromal cell derived exosomes and reveal the mechanism.  Monocrotaline (MCT) induced PH in rats and hypoxia induced cell damage model were established, respectively. Exosomes derived from the supernatant of human umbilical cord mesenchymal stem cells (MSC exo) were injected into MCT PH model rat or added into the cells cultured medium. Immunohistochemistry, quantitative real time polymerase chain reaction (qRT PCR) and western blot methods were used in vivo and vitro  The results showed that MSC exo could significantly attenuate right ventricular (RV) hypertrophy and pulmonary vascular remodelling in MCT PH rats. In the cell culture experiments, we found that MSC exo could significantly inhibit hypoxia induced pulmonary arterial endothelial cell (PAEC) apoptosis and pulmonary arterial smooth muscle cells (PASMC) proliferation. Furthermore, the pulmonary arterioles endothelial to mesenchymal transition (EndMT) was obviously suppressed. Moreover, the present study suggest that MSC exo can significantly upregulate the expression of Wnt5a in MCT PH rats and hypoxic pulmonary vascular cells. Furthermore, with Wnt5a gene silencing, the therapeutic effect of MSC exo against hypoxia injury was restrained.  Synthetically, our data provide a strong evidence for the therapeutic of MSC exo on PH, more importantly, we confirmed that the mechanism was associated with up regulation of the expression of Wnt5a. These results offer a theoretical basis for clinical prevention and treatment of PH.
Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria.
Venue: The Journal of investigative dermatology
Year: 2016

Dysplastic nevi (DNs) also known as Clark's nevi or atypical moles, are distinguished from common melanocytic nevi by variegation in pigmentation and clinical appearance, as well as differences in tissue patterning. However, cellular and molecular differences between DNs and common melanocytic nevi are not completely understood. Using cDNA microarray, quantitative RT PCR, and immunohistochemistry, we molecularly characterized DNs and analyzed the difference between DNs and common melanocytic nevi. A total of 111 probesets (91 annotated genes, fold change 2.0 and false discovery rate 0.25) were differentially expressed between the two lesions. An unexpected finding in DNs was altered differentiation and activation of epidermal keratinocytes with increased expression of hair follicle related molecules (keratin 25, trichohyalin, ribonuclease, RNase A family, 7) and inflammation related molecules (S100A7, S100A8) at both genomic and protein levels. The immune microenvironment of DNs was characterized by an increase of T helper type 1 (IFNg) and T helper type 2 (IL13) cytokines as well as an upregulation of oncostatin M and CXCL1. DUSP3, which regulates cellular senescence, was identified as one of the disease discriminative genes between DNs and common melanocytic nevi by three independent statistical approaches and its altered expression was confirmed by immunohistochemistry. The molecular and cellular changes in which the epidermal melanin unit undergoes follicular differentiation as well as upregulation of defined cytokines could drive complex immune, epidermal, and pigmentary alterations.
Functional and Biomimetic Materials for Engineering of the Three Dimensional Cell Microenvironment.
Venue: Chemical reviews
Year: 2017

The cell microenvironment has emerged as a key determinant of cell behavior and function in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the cell microenvironment serves not only as a structural foundation for cells but also as a source of three dimensional (3D) biochemical and biophysical cues that trigger and regulate cell behaviors. Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, fueling a surge in the development of functional and biomimetic materials for engineering the 3D cell microenvironment. Progress in the design of such materials has improved control of cell behaviors in 3D and advanced the fields of tissue regeneration, in vitro tissue models, large scale cell differentiation, immunotherapy, and gene therapy. However, the field is still in its infancy, and discoveries about the nature of cell microenvironment interactions continue to overturn much early progress in the field. Key challenges continue to be dissecting the roles of chemistry, structure, mechanics, and electrophysiology in the cell microenvironment, and understanding and harnessing the roles of periodicity and drift in these factors. This review encapsulates where recent advances appear to leave the ever shifting state of the art, and it highlights areas in which substantial potential and uncertainty remain.
USE OF INTELLEGENT AND BLOCK CHAIN TECHNOLOGIES IN INFORMATION MANAGEMENT Minsk Innovation University
Year: 2018

The aim of this work is the analysis of methods, approaches, technologies, means of information management (IM) using both conventional technologies and adding new intellectual and block chain. Trends in the use of intelligent technologies in information management are given. The developments in the field of intelligent agents based on semantic web, web services and semantic web services, the use of cloud computing (CC) are shown. The main ideas of semantic technologies, in which a page of the semantic network contains information in two languages: the natural and special, understood only by intelligent software agents (IA) are discussed. The use of block chain technology for the control of various material and non material assets are done. Technically, the block chain technology is another application layer on top of the stack of the Internet protocols and can be integrated with the semantic level. The use of intelligent technologies in the information management in the cloud area with the work of IA. The intelligent web (web 3.0) which became the next stage in the development of the Internet is discussed. It forms the semantics on the ontology dase, creating new opportunities for IA to perform various user requests. Analyzes the major developments in the field of intellectualization of IM, and the main tendencies of their development. The result was a list of criteria and their values, which must meet an intelligent system for IM. As trends in the development of IM is considered the improvement of models and methods of joint activity of IA in the cloud area using block chain technology. Three directions of development of intellectual control system are proposed. As the development of information management proposed the creation of an instrumental platform based on multi agent approach, integrating semantic and block chain technology in the cloud area.
Strategic Planning Process and Organizational Performance in Nigerian Public Sector: A Review of Literature
Year: 2020

This paper aims to review the impact of strategic planning process on organizational performance in the Nigerian public sector. Strategic planning is reported to enhance organizational performance, operations, and overall effectiveness when used in the private and public sectors for decades. Several research findings indicate that large organizations regularly engage in strategic planning, and the plans developed and implemented had a positive impact on the organization's overall performance and effectiveness. Several findings indicated that strategic planning increases the organization's financial performance and longevity, and hence argued that public organizations should adopt the process of strategic planning. It is, therefore, prudent to determine the overall effectiveness of strategic planning for an organization. Hence, this paper focuses on the review of theory, practice, and the impact of strategic planning process on organizational performance among public sector organizations in Nigeria.
Oral Fossilization of College Students in English Acquisition
Year: 2016

Interlanguage fossilization is a universal phenomenon in second language acquisition. In view of the interlanguage fossilization phenomenon in college students' oral English teaching in higher vocational colleges, this paper explores the causes of the students oral English fossilization from students' perspective and teachers' perspective and then puts forward four measures, respectively training language basic skills and cultivating consciousness of pronunciation and grammar, making a balance in the input and output of language, providing appropriate emotional feedback and raising students' psychological quality and including target language culture and minimizing the interference of mother tongue. Thus, the oral English fossilization in oral English of college students can be greatly alleviated or avoided.
Therapeutic effects of near infrared radiation on chronic neck pain
Year: 2013

We aimed to evaluate the therapeutic effects of near infrared radiation on patients with chronic neck pain using various subjective and objective outcome measures.  Thirty participants with chronic neck pain between 20 years and 65 years of age were divided into two groups. Participants in Group A received near infrared therapy every day for 1 week and no intervention in the following week. Group B participants received no intervention during the 1st week and near infrared therapy every day in the following week. Quantitative measures of visual analog scale (VAS) pressure pain threshold (PPT) muscle stiffness, and skin surface temperature were obtained using specific equipment.  Both groups showed significant increases in VAS scores after receiving near infrared therapy. In most of the sampled muscles, PPT values also increased after receiving near infrared therapy in both groups. All other outcome measures collected prior to and after therapy displayed nonsignificant differences.  Results from this pilot study indicate that near infrared therapy reduces pain and partially increases PPT. Further investigation of the long term effects of near infrared therapy on a larger population is warranted.
Fournier's Gangrene: Epidemiology and Outcomes in the General US Population
Venue: Urologia Internationalis
Year: 2016

Case series reported 20 40% mortality rates for patients with Fournier's gangrene with some series as high as 88% This literature comes almost exclusively from referral centers.  We identified and analyzed inpatients with Fournier's gangrene who had a surgical debridement or died in the US State Inpatient Databases.  One thousand six hundred and forty one males and 39 females with Fournier's gangrene represented <0.02% of hospital admissions. Overall, the incidence was 1.6 cases per 100,000 males and case fatality was 7.5% Sixty six percent of hospitals cared for no cases per year, 17% cared for 1 case per year, 10% cared for 2 cases per year, 4% cared for 3 cases per year, 1% cared for 4 cases per year, and only 1% cared for =5 cases per year. Teaching hospitals had higher mortality (adjusted OR 1.9) due primarily to more acutely ill patients. Hospitals treating more than 1 Fournier's gangrene case per year had an adjusted 42 84% lower mortality (p 0.0001)  Most hospitals rarely care for Fournier's gangrene patients. The population based mortality rate (7.5% was substantially lower than the case series from tertiary care centers. Hospitals that treated more number of Fournier's gangrene patients had lower mortality rates, thereby supporting the rationale that regionalized care worked well for patients with this rare disease.
Conifer Fossil Woods from the Sobral Formation (Lower Paleocene, Western Antarctica)
Venue: Ameghiniana
Year: 2017

Conifer fossil woods represent 54% of an assemblage of 116 specimens collected from sediments of the Sobral Formation in Seymour (Marambio) Island, Western Antarctica. These woods are anatomically described in detail and assigned to seven fossil species of the following fossil genera: Agathoxylon (Araucariaceae) Podocarpoxylon, Phyllocladoxylon, Protophyllocladoxylon (Podocarpaceae) and Cupressinoxylon (Podocarpaceae/Cupressaceae) The conifer wood assemblage reveals that the most common woods are those of Agathoxylon, therefore indicating a relative abundance of the Araucariaceae in the Antarctic Paleocene forests. This abundance of the Araucariaceae woods is locally continued in the overlying Cross Valley Formation (Paleocene) Podocarpaceae woods are found in almost similar proportions to those of the Araucariaceae. Almost the other half of the fossil woods are dicotyledon woods. The proportions of the identified fossil wood taxa are consistent with those of the palynological studies of the same stratigraphic unit.
Obtaining oil from macauba kernels by ultrasound assisted extraction using ethyl acetate as the solvent
Year: 2019

The objective of this work was to evaluate the efficacy of ethyl acetate as a solvent in the extraction of macauba kernel oil (MKO) using ultrasonic assisted extraction (UAE) It was shown that more MKO oil could be extracted with the use of larger amounts of solvent, higher temperatures and longer extraction times. Thus the maximum oil yield (40.61% was obtained by UAE at 60 degC for 45 min, using a solvent to kernel ratio of 12 (mL g 1) obtaining a higher yield than that obtained with n hexane under the same experimental conditions. UAE was favorable for this oil extraction (p 0.05) presenting a yield close to that reported for classical extraction but with a shorter extraction time and smaller solvent volume. Lauric acid corresponded to ~44% of the MKO composition. The oils presented low free fatty acid contents <0.80% wt) and the phytosterols, campesterol and b sitosterol, were identified in the MKO with higher levels in the oil obtained by UAE.
ANALISIS PERENCANAAN OBAT DENGAN MENGGUNAKAN METODE KONSUMSI DI INSTALASI FARMASI DINAS KESEHATAN KOTA KEDIRI TAHUN 2017
Year: 2018

Latar belakang: Obat memegang peran yang penting untuk meningkatkan derajat kesehatan. Pengelolaan obat kabupaten atau kota merupakan tanggung jawab penuh dari pemerintah kabupaten atau kota.  Untuk mengetahui perencanaan kebutuhan obat menggunakan metode konsumsi di Instalasi Farmasi Dinas Kesehatan Kota Kediri tahun 2017.  Jenis penelitian deskriptif observasional dengan desain rancangan retrospektif menggunakan data Laporan Pemakaian dan Lembar Permintaan Obat (LPLPO) UPTD Puskesmas di seluruh Kota Kediri dan juga melakukan wawancara mendalam. Hasil: Berdasarkan analisis ABC terhadap rencana kebutuhan obat tahun 2017 terlihat bahwa dari 215 jenis obat yang perlu dilakukan pengadaan obat hanya 115 jenis obat, yang terdiri dari 25 jenis item obat termasuk kelompok A (21,74% dengan biaya pengadaan sebesar Rp 605.826.367, (70,21% Sebanyak 23 item obat termasuk dalam kelompok B (20,00% dengan biaya sebesar Rp 145.323.838, (16,84% dan kelompok C sebanyak 67 item (58,26% dengan biaya sebesar Rp 111.708.155, (12,95% Hasilnya didapatkan bahwa anggaran yang dibutuhkan untuk pengadaan obat sebanyak Rp 863.830.208, Simpulan: Perencanaan kebutuhan obat di Instalasi Farmasi Dinas Kesehatan Kota Kediri belum sepenuhnya sesuai dengan perhitungan perencanaan yang tertera pada Kepmenkes RI Nomor: 1121/Menkes/SK/XII/2008 tentang Pedoman Tehnis pengadaan obat publik dan perbekalan kesehatan.
Synthesis and properties of G quartet oligonucleotide HIV 1 tat peptide conjugate.
Venue: Nucleic acids symposium series
Year: 2006

Zintevir is a single strand DNA that forms an intramolecular quadruplex structure and shows potent anti human immunodeficiency virus type 1 (HIV 1) activity. Zintevir was discovered as a potent inhibitor for HIV 1 integrase. Recently, the primary molecular target of Zintevir, however, was shown to be the HIV 1 gp120. In fact, in our previous study, Zintevir was shown to inhibit the only processes of the viral adsorption and the entry into the cell. This result suggests that Zintevir is not able to penetrate through the cell membranes. Therefore, we designed and synthesized the complex of D 17mer with HIV 1 tat peptide that has the cell membrane permeability.
Exploring the multi sided nature of crowdfunding campaign success
Year: 2018

Successful crowdfunding campaigns are multifaceted in nature and depend on marketing and organizational features. This study identifies the most appealing factors and analyzes the results through a multi theory approach as follows. First, contrary to altruism and warm glow giving theories, crowdfunding to support social impact projects does not perform well. Second, fixed campaigns, small sized projects, and prolonged campaigns are more likely to be funded, in line with goal setting theory. Additionally, the resource based view of firms clarifies the importance of having large entrepreneurial teams. Further, narrative theories about persuasion and information processing provide insights into why detailed text descriptions are more persuasive than pitch videos. Finally, this study relies on social identity and signaling theories to illustrate the impressive role of social networks and discussion forums between fundraisers and backers for developing effective word of mouth. This paper also provides fundraisers with recommendations to building appealing campaigns.
La incertidumbre en el paciente con leucemia aguda al inicio del tratamiento una propuesta de cuidado
Year: 2019

To determine the Nursing care aimed at the patient with Acute Leukemia (LA) who attends three hematology units of three 4th level institutions, based on the level of uncertainty that is generated at the diagnosis and onset of treatment.  Quantitative, descriptive, cross sectional study conducted with 21 adult patients in the city of Bogota. It is specifically the instrument (MUIS ADULT) Uncertainty scale before Mishel disease. The data was processed in R Software for multiple correspondence analysis. For the bivariate analysis, the Chi Square and Kruskal Wallis test was applied.  The level of uncertainty was high in 52.4% and average in 42.9% of the sample. By dimensions, it is evident that the most limited was Cognitive Capacity 60.4% The analysis of multiple correspondences without evidence relationship between the variables of the instrument and the type of disease, age or sex. There is no evidence difference in the answers identified the type of medical diagnostic. A bivariate analysis was performed associating schooling and the level of uncertainty with a significance of 0.10.  Patients diagnosed with LA have a regular and high degree of uncertainty. In response, the proposal of Patient Care is proposed based on the factors that increase uncertainty. There is no evidence describing the phenomenon of Uncertainty in the adult patient with LA, which poses an opportunity in research to contribute to nursing knowledge and lead to the improvement of care practices.
Astrocyte mediated switch in spike timing dependent plasticity during hippocampal development
Venue: Nature communications
Year: 2020

Presynaptic spike timing dependent long term depression (t LTD) at hippocampal CA3 CA1 synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week. At more mature stages, we found that the protocol that induced t LTD induced t LTP. We characterized this form of t LTP and the mechanisms involved in its induction, as well as that driving this switch from t LTD to t LTP. We found that this t LTP is expressed presynaptically at CA3 CA1 synapses, as witnessed by coefficient of variation, number of failures, paired pulse ratio and miniature responses analysis. Additionally, this form of presynaptic t LTP does not require NMDARs but the activation of mGluRs and the entry of Ca2+ into the postsynaptic neuron through L type voltage dependent Ca2+ channels and the release of Ca2+ from intracellular stores. Nitric oxide is also required as a messenger from the postsynaptic neuron. Crucially, the release of adenosine and glutamate by astrocytes is required for t LTP induction and for the switch from t LTD to t LTP. Thus, we have discovered a developmental switch of synaptic transmission from t LTD to t LTP at hippocampal CA3 CA1 synapses in which astrocytes play a central role and revealed a form of presynaptic LTP and the rules for its induction.
Problemy dializoterapii pacjentow z nefropatia cukrzycowa
Year: 2009

Cukrzyca i mocznica nasilaja wzajemnie angiopatie, neuropatie oraz niedokrwistosc i dlatego kontrola cukrzycy i intensywna dializoterapia sa niezbedne dla poprawy rokowania co do chorobowosci i przezycia w tej grupie chorych. Nie kazdy dializowany chory na cukrzyce ma nefropatie cukrzycowa, ale powinien byc tak traktowany. W ostrej niewydolnosci nerek u pacjentow z cukrzyca korzystna jest intensywna insulinoterapia i utrzymywanie glikemii w granicach 110 140 mg/dl. U dializowanych z powodu przewleklej niewydolnosci nerek leczenie cukrzycy jest w zasadzie takie jak w okresie przeddializacyjnym, a zabiegi dializ nie odbiegaja jakosciowo od stosowanych u pacjentow bez cukrzycy. Z lekow hipoglikemizujacych najbezpieczniejsze sa glipizyd i gliklazyd krotkodzialajace pochodne sulfonylomocznika drugiej generacji. Dializa otrzewnowa i hemodializa u pacjentow z cukrzyca daja porownywalne wyniki leczenia. Najpowazniejsze problemy u dializowanych z cukrzyca to przyspieszona angiopatia (retinopatia, stopa cukrzycowa) oraz nasilona neuropatia wegetatywna (sklonnosc do hipotensji w czasie hemodializ, gastropareza) Mimo ogromnego postepu w dializoterapii pacjentow z cukrzyca, jaki sie dokonal w ostatnich latach, rokowanie co do dozycia tej grupy pacjentow jest nadal gorsze niz u pozostalych dializowanych. Dalszej poprawy oczekuje sie dzieki stosowaniu agresywnej kontroli cukrzycy, prewencji jej powiklan (zwlaszcza angiopatii, w tym zespolu stopy cukrzycowej) unikanie intensywnej ultrafiltracji i zwiekszenie intensywnosci dializ, a u dializowanych otrzewnowo stosowanie w plynie dializacyjnym ikodekstryny zamiast glukozy w wysokim stezeniu.