nils-herrmann/clean_scirepeval huggingface dataset:
Toward the Establishment of Standardized In Vitro Tests for Lipid Based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the In Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid Based Formulations
Venue: Pharmaceutical Research
Year: 2013

PurposeRecent studies have shown that digestion of lipid based formulations (LBFs) can stimulate both supersaturation and precipitation. The current study has evaluated the drug, formulation and dose dependence of the supersaturation precipitation balance for a range of LBFs.MethodsType I, II, IIIA/B LBFs containing medium chain (MC) or long chain (LC) lipids, and lipid free Type IV LBF incorporating different doses of fenofibrate or tolfenamic acid were digested in vitro in a simulated intestinal medium. The degree of supersaturation was assessed through comparison of drug concentrations in aqueous digestion phases (APDIGEST) during LBF digestion and the equilibrium drug solubility in the same phases.ResultsIncreasing fenofibrate or tolfenamic acid drug loads (i.e. dose) had negligible effects on LC LBF performance during digestion, but promoted drug crystallization (confirmed by XRPD) from MC and Type IV LBF. Drug crystallization was only evident in instances when the calculated maximum supersaturation ratio (SRM) was >3. This threshold SRM value was remarkably consistent across all LBF and was also consistent with previous studies with danazol.ConclusionsThe maximum supersaturation ratio (SRM) provides an indication of the supersaturation 'pressure' exerted by formulation digestion and is strongly predictive of the likelihood of drug precipitation in vitro. This may also prove effective in discriminating the in vivo performance of LBFs.
Embedding an Exoskeleton Hand in the Astronaut's EVA Glove: Feasibility and Ideas
Year: 2012

This paper investigates the key factors associated to the realization of a hand exoskeleton to be embedded in an astronaut's EVA glove, in order to overcome the stiffness of the pressurized space suit. An overview regard ing the main constraints related to the realization of a hand exoskeleton for EVA suits is provided, as well as a preliminary concept analysis of possible solutions in terms of mechanical structure, actuators and sensors. Furthermore, analyses of human hand kinemat ics and of the characteristics of the EVA glove's stiffness are presented, as a basis for design and dimensioning of the exoskeleton. The future exoskeleton will be a co mp lex mechatronic system detecting the operator's movement through sensors, processing the acquired data and generating the motion through its actuation system.
Design of Dual Band Frequency Selective Rasorber
Venue: IEEE Antennas and Wireless Propagation Letters
Year: 2019

A novel frequency selective rasorber (FSR) with dual band transmission and wideband absorption property is proposed in this letter. The FSR is a two layer structure composed of a lossy resistive sheet at the top and a lossless bandpass frequency selective surface (FSS) at the bottom, separated by an air spacer. The element of the resistive sheet is a lumped resistor loaded metallic dipole with a dual resonance structure inserted in the center. The dual resonance structure is realized by three different series LC structures in parallel, based on the Foster reactance theorem. There are two impedance poles between the three impedance zeros of the series LC circuits, where two transparent windows can be obtained for the lossy resistive sheet. The bandpass FSS is a simple dual band FSS by etching two slots with different shapes and dimensions in a metallic plane. The FSR has realized two transmission bands at 7.7 and 12.6 GHz, and the band with |S11| 10 dB is 3.7 11.1 GHz. The design has been validated by full wave simulation and experimental measurement.
STRATEGI PEMASARAN SEKOLAH DASAR ISLAM TERPADU NURUL FIKRI TULUNGAGUNG
Year: 2015

STRATEGI PEMASARAN SEKOLAH DASAR ISLAM TERPADU NURUL FIKRI TULUNGAGUNG Marketing Strategy Integrated Islamic Elementary School Nurul Fikri Tulungagung Supar SMAN 1 Kauman Kab Tulungagung  has a new product that should be offered to the public SDIT Nurul Fikri Tulungagung very interested in the community, the number of students who enroll more and more, exceeding its capacity. This is the factor that is interesting to study how marketing strategies. One effective way of marketing is the model of kinship. In fact many new parents finally know and are interested in the institution as it gets references from friends, relatives or co workers in the office. This qualitative research gets the data from the known, done, experienced and perceived by informants. JSIT curriculum Quran by rote, rote praying in everyday is a new product for the community. The fundamental requirement education service is preferred for example exemption or reduction of school fees, scholarships for achievement, health checks and consultations child development.  Marketing Strategy, Barriers, products, networks. ABSTRAK Sekolah Dasar Islam Terpadu (SDIT) mempunyai produk baru yang harus ditawarkan pada masyarakat SDIT Nurul Fikri Tulungagung sangat diminati masyarakat, jumlah murid yang mendaftar semakin banyak, melebihi daya tampungnya. Inilah faktor yang menarik untuk diteliti, bagaimana strategi pemasarannya. Salah satu cara marketing yang efektif adalah dengan model kekerabatan. Kenyataanya banyak wali murid baru akhirnya kenal dan tertarik dengan lembaga karena mendapat referensi dari teman, saudara atau rekan kerja di kantor. Penelitian kualitatif ini mendapat data dari yang diketahui, dilakukan, dialami dan dirasakan oleh informan. Kurikulum JSIT dengan hafalan Al Qur'an, hafalan doa doa keseharian merupakan produk baru bagi masyarakat. Pelayanan kebutuhan mendasar perndidikan sangat diutamakan misalnya pembebasan atau keringanan biaya sekolah, beasiswa anak berprestasi, pemeriksaan kesehatan dan konsultasi perkembangan anak.  Strategi Pemasaran, Hambatan, Produk, jaringan.
Challenges in exploiting open innovation's full potential in the food industry with a focus on small and medium enterprises (SMEs)
Year: 2014

The food industry, and especially small and medium enterprises in that industry, are faced with numerous complex challenges that open innovation addresses. The main topics reviewed here are: adapting open innovation for the food industry's special needs, small and medium enterprises' unique challenges, open innovation solution providers, the roles of academia and the intellectual properties model. Some specific recommendations include: collaboration, creation of a new innovation ecosystem (industry, academia, government and private business) metrics to quantify academia's social responsibility and revised curricula promoting open innovation and innovation, small and medium enterprise involvement, a new intellectual properties model, and management mindsets and strategies. Open innovation is an opportunity for all stakeholders to proactively engage in meeting future challenges and opportunities.
One point binding chiral ruthenium Lewis acid catalysts: asymmetric intramolecular Diels Alder reactions and conformational studies
Year: 2011

Half sandwich chiral electron poor one point binding ruthenium catalyst that I focused on was one of the research interests in the Kundig group. A more general aim was to apply these catalysts to new transformations, expanding the range of applications that these complexes can satisfactorily catalyze. Only one successful example of asymmetric type 2 IMDA cycloaddition was reported. The challenges arise from the facts that several inconsistencies remain in the reported structure assignment of ledol. We therefore employed the crucial intermediate for the first total synthesis of ent ledol to provide in good yield with excellent ee. The conformational studies of Ru dienophile complexes with NOESY and ROESY experiments revealed a conformationally coordinate structure with correlations between dienophile protons and Cp/Indenyl 'roof' or chiral BIPHOP F ligand protons of catalyst part. These NMR results helped to explain the ground state conformations in solution that probably correspond to the observed enantioselectivity in DA reactions.
Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons
Venue: Neuron
Year: 2016

Purkinje cells (PCs) provide the sole output from the cerebellar cortex. Although PCs are well characterized on many levels, surprisingly little is known about their axon collaterals and their target neurons within the cerebellar cortex. It has been proposed that PC collaterals transiently control circuit assembly in early development, but it is thought that PC to PC connections are subsequently pruned. Here, we find that all PCs have collaterals in young, juvenile, and adult mice. Collaterals are restricted to the parasagittal plane, and most synapses are located in close proximity to PCs. Using optogenetics and electrophysiology, we find that in juveniles and adults, PCs make synapses onto other PCs, molecular layer interneurons, and Lugaro cells, but not onto Golgi cells. These findings establish that PC output can feed back and regulate numerous circuit elements within the cerebellar cortex and is well suited to contribute to processing in parasagittal zones.
Stop loss and leverage in optimal statistical arbitrage with an application to energy market
Venue: Energy Economics
Year: 2019

In this paper we develop a statistical arbitrage trading strategy with two key elements in hi frequency trading: stop loss and leverage. We consider, as in Bertram (2009) a mean reverting process for the security price with proportional transaction costs; we show how to introduce stop loss and leverage in an optimal trading strategy. We focus on repeated strategies using a self financing portfolio. For every given stop loss level we derive analytically the optimal investment strategy consisting of optimal leverage and market entry/exit levels. First we show that the optimal strategy a' la Bertram depends on the probabilities to reach entry/exit levels, on expected First Passage Times and on expected First Exit Times from an interval. Then, when the underlying log price follows an Ornstein Uhlenbeck process, we deduce analytical expressions for expected First Exit Times and we derive the long run return of the strategy as an elementary function of the stop loss. Following industry practice of pairs trading we consider an example of pair in the energy futures' market, reporting in detail the analysis for a spread on Heating Oil and Gas Oil futures in one year sample of half an hour market prices.
The relationship between working alliance and client outcomes in coaching: A meta analysis
Venue: Human Relations
Year: 2019

A growing number of studies emphasize the working alliance between the client and the coach to be a key factor in coaching. Synthesizing 27 samples (N 3563 coaching processes) this meta analysis sheds light on the relationship between working alliance and a broad range of coaching outcomes for clients. The meta analytic results indicate a moderate and consistent overall relationship between a high quality working alliance and coaching outcomes for clients (r .41, 95% CI .34, .48] p .001) Working alliance was positively related to all desirable coaching outcomes (range: r .32 to .64) with the strongest relationship to affective and cognitive coaching outcomes. Moreover, working alliance was negatively related to unintended negative effects of coaching (r .29) Results revealed no differences regarding the type of clients, coaches' expertise, number of coaching sessions, and clients' or coaches' perspectives. Similar to other helping relationships like psychotherapy or mentoring, the results support the importance of a high quality working alliance in coaching.
Mutiny and nonviolence in the Arab Spring
Year: 2013

Recent studies of civil resistance indicate that security force defections can heavily influence the outcome of nonviolent uprisings against authoritarian regimes. Yet we know little about why, when, and how mutiny occurs. In this article, I ask: what factors influence the likelihood of military defections during a nonviolent conflict? In reviewing various literatures, I identify ten factors that facilitate or obstruct mutiny. I propose that two of these are particularly influential: (1) whether troops receive economic or political benefits from the regime; and (2) whether troops perceive the regime as fragile, based on the international community's response to the conflict. Specifically, I argue that troops who receive benefits from a regime are more likely to remain loyal while those who receive no such benefits are more likely to defect. However, even the most underprivileged troops are unlikely to defect if they believe that the state is strong enough to withstand a major civilian uprising. Soldiers' perception of regime strength is partly shaped by whether outside nations support the opposition, thereby weakening the state, or send troops to reinforce the regime's control. Using a qualitative comparative method, I illustrate these dynamics through an examination of several Arab Spring uprisings: Egypt, where the military sided with civil resisters; Bahrain, where troops remained loyal to the state; and Syria, where the military split. Then, to encourage more research on this topic, I use these three cases to generate additional hypotheses about defections that others can test against a wider set of cases. I conclude with a discussion of the questions that future researchers should explore and the types of methodological approaches that are needed in this field of study.
An Analysis on Automatic Performance Optimization in Database Management Systems
Venue: 2020 World Conference on Computing and Communication Technologies (WCCCT)
Year: 2020

Maintaining database management systems under optimum condition is crucial for any enterprise application as it affects the overall system performance. However, the optimization process is a non trivial task even for experienced database administrators due to many underlying challenges. Due to the importance of database optimization, this domain has been researched for the past several years. In this analysis starting off with discussing the importance of an optimum database for the overall performance, then we focus on the reasons behind the poor performance of database management systems. Database optimization is divided under two main categories as Physical design based optimization and Configuration parameter based optimization. While both of these will be discussed, the priority is given for the Configuration parameter optimization. Configuration based optimization comes with its own set of challenges as of 1) Large configuration parameter space, 2) Interdependency of configuration parameters, and 3) Configuration change with different types of workloads. These challenges will be elaborated while carrying out an analysis on the different approaches used in preexisting work to overcome the challenges. Finally, the paper would focus on foundations of optimization techniques which can be utilized for the configuration based database optimization process.
Zinc finger nucleases for somatic gene therapy: the next frontier.
Venue: Human gene therapy
Year: 2011

Zinc finger nucleases (ZFNs) are a powerful tool that can be used to edit the human genome ad libitum. The technology has experienced remarkable development in the last few years with regard to both the target site specificity and the engineering platforms used to generate zinc finger proteins. As a result, two phase I clinical trials aimed at knocking out the CCR5 receptor in T cells isolated from HIV patients to protect these lymphocytes from infection with the virus have been initiated. Moreover, ZFNs have been successfully employed to knockout or correct disease related genes in human stem cells, including hematopoietic precursor cells and induced pluripotent stem cells. Targeted genome engineering approaches in multipotent and pluripotent stem cells hold great promise for future strategies geared toward correcting inborn mutations for personalized cell replacement therapies. This review describes how ZFNs have been applied to models of gene therapy, discusses the opportunities and the risks associated with this novel technology, and suggests future directions for their safe application in therapeutic genome engineering.
Cultural Diversity in Business: A Critical Reflection on the Ideology of Tolerance
Year: 2017

Cultural diversity is an increasingly important phenomenon that affects not only social and political harmony but also the cohesion and efficiency of organisations. The problems that firms have with regard to managing cultural diversity have been abundantly studied in recent decades from the perspectives of management theory and moral philosophy, but there are still open questions that require deeper reflection and broader empirical analysis. Managing cultural diversity in organisations is of prime importance because it involves harmonising different values, beliefs, credos and customs, and, in essence, human identity. Taking into consideration these cultural differences and harmonising them is a human rights issue (UNDP, Cultural liberty in today's diverse world, 2004) and a central dimension of corporate social responsibility. Here we are going to focus on theoretical reflection about the ideas that lie behind corporate policies and organisational initiatives that deal with cultural diversity. The aim of our paper is twofold: to present a critical reflection on the ideology of tolerance, and propose an ideology of respect for dealing with cultural diversity. We start by presenting the plurality of interpretations of the concept of ideology, and justify its applicability to the field of cultural diversity. We then reflect on the differences between "tolerance" and "respect" and identifying the practical implications for managing cultural diversity. And finally, we propose a culture of respect that goes beyond tolerance and complements and legitimizes the "business case" perspective for managing cultural diversity in companies. The ideology of respect is based on the Kantian tradition and on the discursive approach where rational dialogue and argumentation are considered the legitimate process for creating a culture of intercultural respect. From this theoretical discussion of the key philosophical concepts we can suggest some general principles for managing cultural diversity in organisations.
Thermoelectric properties of La3+ and Ce3+ co doped CaMnO3 prepared by tape casting
Year: 2020

The structural and thermoelectric transport properties of Ca0.9La0.1 xCexMnO3 d (x 0 0.1) prepared through tape casting process were investigated. The thermoelectric transport properties of CaMnO3 were optimized by the La3+ and Ce3+ co doping and tape casting process. The Ce3+ substitution substantially enhanced the dimensionless figure of merit (ZT) due to the increases in electrical conductivity and absolute Seebeck coefficient. Of the studied samples, Ca0.9La0.025Ce0.075MnO3 d had the maximum ZT (0.17) at 800 degC, and this value was 42% and 70% larger than those of singly doped Ca0.9La0.1MnO3 d (0.12) and Ca0.9Ce0.1MnO3 d (0.10) respectively. We demonstrate that both the La3+ and Ce3+ co doping and tape casting process are highly promising approaches in enhancing the high temperature thermoelectric transport properties of CaMnO3.
Cell Culture Experiments Reveal that High S100B and Clusterin Levels may Convey Hypoxia tolerance to the Hooded Seal (Cystophora cristata) Brain
Venue: Neuroscience
Year: 2020

While the brain of most mammals suffers from irreversible damage after only short periods of low oxygen levels (hypoxia) marine mammals are excellent breath hold divers that have adapted to hypoxia. In addition to physiological adaptations, such as large oxygen storing capacity and strict oxygen economy during diving, the neurons of the deep diving hooded seal (Cystophora cristata) have an intrinsic tolerance to hypoxia. We aim to understand the molecular basis of this neuronal hypoxia tolerance. Previously, transcriptomics of the cortex of the hooded seal have revealed remarkably high expression levels of S100B and clusterin (apolipoprotein J) when compared to the ferret, a non diving carnivore. Both genes have much debated roles in hypoxia and oxidative stress. Here, we evaluated the effects of S100B and of two isoforms of clusterin (soluble and nucleus clusterin) on the survival, metabolic activity and the amount of reactive oxygen species (ROS) in HN33 neuronal mouse cells exposed to hypoxia and oxidative stress. S100B and soluble clusterin had neuroprotective effects, with reduced ROS levels and retention of normoxic energy status of cells during both stress conditions. The protective effects of nucleus clusterin were restricted to hypoxia. S100B and clusterin showed purifying selection in marine and terrestrial mammals, indicating a functional conservation across species. Immunofluorescence revealed identical cellular distributions of S100B and clusterin in mice, ferrets and hooded seals, further supporting the functional conservation. Taken together, our data suggest that the neuroprotective effects of all three proteins are exclusively facilitated by their increased expression in the brain of the hooded seal.
Dehydrogenation of Methane by Partially Oxidized Tungsten Cluster Cations: High Reactivity Comparable to That of Platinum Cluster Cations.
Venue: The journal of physical chemistry. A
Year: 2019

Gas phase reactivity of pure and partially oxidized tungsten atomic and cluster cations, Wn+ (n 1 6) and WnOm+ (n 1 5, m 6) with methane is studied at the collision energies from 0.1 to 1.0 eV under single collision conditions. The dehydrogenation of CH4 (i.e. the release of H2) is observed for most of WnOm+ whereas Wn+ (n 2) are almost unreactive. This result indicates that the reactivity of tungsten clusters can be enhanced by the addition of oxygen atoms. Moreover, the reaction cross section of WnOm+ strongly depends on the cluster composition, and some clusters such as W2O3+ W3O+ W3O5+ and W5O3+ exhibit high reactivity. It turns out that the reactivity of these clusters is roughly comparable to that of typical platinum cluster cations, which are one of the most reactive clusters toward the methane dehydrogenation. The reactivity of Wn+ and WnOm+ toward CH4 can be explained by a simple model of their orbital energies and the potential energy diagrams obtained by using the density functional theory calculations. The calculations also suggest that the oxygen atom(s) in WnOm+ is like a spectator and the formation of a hydroxyl group is not necessary for the cleavage of C H bonds in CH4.
A Novel Technique of Power Flow Control in Transmission Lines Using Interline Power Flow Control
Year: 2016

The interline power flow control (IPFC) is the flexible AC transmission system controller (FACTS) came into accountability to control the flow of power in multiple line transmission system. The following paper demonstrates the IPFC modelling using Matlab Simulink. Power flow calculations has been made using Gauss Seidel Method. Optimization of power in terms of real and reactive power flow is achieved by comparing the actual calculated term and the predicted value.  PDF