nils-herrmann/clean_scirepeval huggingface dataset:
A learning based method for drug target interaction prediction based on feature representation learning and deep neural network
Venue: BMC Bioinform.
Year: 2020

Drug target interaction prediction is of great significance for narrowing down the scope of candidate medications, and thus is a vital step in drug discovery. Because of the particularity of biochemical experiments, the development of new drugs is not only costly, but also time consuming. Therefore, the computational prediction of drug target interactions has become an essential way in the process of drug discovery, aiming to greatly reducing the experimental cost and time.  We propose a learning based method based on feature representation learning and deep neural network named DTI CNN to predict the drug target interactions. We first extract the relevant features of drugs and proteins from heterogeneous networks by using the Jaccard similarity coefficient and restart random walk model. Then, we adopt a denoising autoencoder model to reduce the dimension and identify the essential features. Third, based on the features obtained from last step, we constructed a convolutional neural network model to predict the interaction between drugs and proteins. The evaluation results show that the average AUROC score and AUPR score of DTI CNN were 0.9416 and 0.9499, which obtains better performance than the other three existing state of the art methods.  All the experimental results show that the performance of DTI CNN is better than that of the three existing methods and the proposed method is appropriately designed.
Spiritual Ecological Analysis of the Main Characters in The Scarlet Letter
Year: 2012

All of the three main characters in The Scarlet Letter are tortured greatly in spirit.The heroine Hester is brave and strong.By facing directly her sin,she finds the balance between her inner feelings and the outside world and eventually gets the peace of mind and becomes helpful to others.Dimmesdale is weak and coward.Under the pressure of fear and remorse,his physical health is greatly devastated.He doesn't get back his mental peace until he makes a public confession at the end of his life.Overwhelmed by hatred,Chillionworth is cruel and evil.His dehumanized revenge not only destroys his enemy,but also destroys himself.He can't get the peace of mind even at the end of his life.
Communication efficient Decentralized Machine Learning over Heterogeneous Networks
Venue: 2021 IEEE 37th International Conference on Data Engineering (ICDE)
Year: 2021

In the last few years, distributed machine learning has been usually executed over heterogeneous networks such as a local area network within a multi tenant cluster or a wide area network connecting data centers and edge clusters. In these heterogeneous networks, the link speeds among worker nodes vary significantly, making it challenging for state of the art machine learning approaches to perform efficient training. Both centralized and decentralized training approaches suffer from low speed links. In this paper, we propose a decentralized approach, namely NetMax, that enables worker nodes to communicate via high speed links and, thus, significantly speed up the training process. NetMax possesses the following novel features. First, it consists of a novel consensus algorithm that allows worker nodes to train model copies on their local dataset asynchronously and exchange information via peer to peer communication to synchronize their local copies, instead of a central master node (i.e. parameter server) Second, each worker node selects one peer randomly with a fine tuned probability to exchange information per iteration. In particular, peers with high speed links are selected with high probability. Third, the probabilities of selecting peers are designed to minimize the total convergence time. Moreover, we mathematically prove the convergence of NetMax. We evaluate NetMax on heterogeneous cluster networks and show that it achieves speedups of 3.7x, 3.4x, and 1.9x in comparison with the state of the art decentralized training approaches Prague, Allreduce SGD, and AD PSGD, respectively.
Gene Therapy for "Bubble Boy" Disease
Venue: Cell
Year: 2016

Adenosine deaminase (ADA) deficiency results in the accumulation of toxic metabolites that destroy the immune system, causing severe combined immunodeficiency (ADA SCID) often referred to as the "bubble boy" disease. Strimvelis is a European Medicines Agency approved gene therapy for ADA SCID patients without a suitable bone marrow donor.
Determinantes de la satisfaccion en el trabajo de las enfermeras comunitarias de la DISA V, Lima Ciudad
Year: 2008

Objetivo: identificar los factores determinantes que condicionan la satisfaccion en el trabajo de las enfermeras comunitarias.  la edad promedio de las enfermeras comunitarias fue de 37,8 mas menos 12,9, con predominio del sexo femenino. Entre los factores determinantes de la satisfaccion en el trabajo remuneracion economica, condiciones de trabajo, relaciones interpersonales y el reconocimiento laboral destaco el nivel medianamente satisfecho; contribuye a esta satisfaccion el salario recibido/percibido, cubrir las necesidades basicas (0,000) modalidad de empleo, orden, limpieza, ventilacion del ambiente de trabajo y disponibilidad de insumos laborales (0,001 y 0,002) trabajo en equipo e interrelacion con el jefe (0,000 y 0,001) accesibilidad a cambios de turno y reconocimiento por parte de la institucion y del jefe (0,000; 0,001 y 0,003) Conclusiones: considerando los factores determinantes de la satisfaccion en el trabajo en estudio las enfermeras se identificaron como medianamente satisfechos.  identify determinants factors that influence of job satisfaction of community nurses.  quantitative, descriptive and correlational study, that includes a population sample of 178 nurses from primary care level centers from Directorate of Health (DISA) V u Lima City; during the months of May 2007 April 2008; for data collection was used a self applied questionnaire formed by socio u demographic characteristics, educational background, determinants and indicators of job satisfaction; in the analysis was used descriptive statistic and to correlate variables the coefficient of Pearson, considering a significant alpha=0.05.  the average age of community nurses was 37.8 more less 12.9, predominantly female. Among factors related to the of job satisfaction uremuneration, job conditions, inter personal relationships and personal recognition was highlighted the medium satisfaction level; being the contributors, of this satisfaction the following indicators: received salary, meet basic needs (0.000) type of employment, order, clean, environmental work ventilation and availability of labor supplies (0.001 y 0.002) team work and inter relation whit boss (0.000 y 0.001) accessibility to shift changes, reward of institution and boss (0.000; 0.001 y 0.003) Conclusions: considering the determinants of job satisfaction in the nurses study were identified as moderately satisfied.
Real World Characterization of Women with Diagnosed Endometriosis Initiating Therapy with Elagolix Using a US Claims Database
Venue: ClinicoEconomics and outcomes research CEOR
Year: 2020

Elagolix is an oral gonadotropin releasing hormone antagonist approved in the United States for the management of moderate to severe pain associated with endometriosis. We performed a real world evaluation of the demographic and clinical characteristics of women diagnosed with endometriosis who were initiating elagolix therapy in the United States.  This retrospective cohort database analysis included women 18 49 years of age with =1 pharmacy claim for elagolix between August 2018 and December 2019 from the Copyright (c) 2020 Truven Health Analytics LLC.  Women had continuous medical and pharmacy health plan enrollment during the baseline period (year immediately preceding the index date [date of earliest elagolix claim] and had =1 medical claim with endometriosis (International Classification of Diseases [ICD] 9/10 code [617.x and N80.x] on or before the index date. Baseline demographics, comorbidities, ICD code based endometriosis anatomic site, endometriosis related treatments, and pain symptoms were summarized descriptively.  The study included 2083 patients with mean age at baseline of 33.2 8.1 years. Comorbidities most commonly recorded were non cancer, non endometriosis pain (59.5% including arthritis/joint pain (43.7% and back/neck pain (31.7% and mental disorder (40.7% including anxiety (32.7% The majority of endometriosis diagnosis codes recorded referred to unspecified location (52.3% and pelvic peritoneum (23.0% 61.0% of patients received a medical endometriosis related treatment in the baseline period, with the most common treatments being contraceptives (various routes of administration, 40.2% and progestins (31.7% Additionally, 35.4% of the patients received an endometriosis related surgery during baseline, with the most common being laparoscopy (33.2% of all patients) Opioids were used during the baseline period by 57.3% of the patients. For pain symptoms, 71.5% 30.4% and 19.3% of the patients had claims for pelvic pain, dysmenorrhea, and dyspareunia, respectively.  Endometriosis therapies were used by a significant proportion of patients with endometriosis in the year immediately preceding elagolix initiation.
PENGARUH PEMBERIAN PUPUK KANDANG SAPI DAN PUPUK ABG TERHADAP PERTUMBUHAN DAN PRODUKSI TIMUN (Cucumis sativus L.
Year: 2015

Research of the effect of cow manure and fertilizer on the growth and production ABG cucumber has been conducted on Tuar street, in the field trials of Agriculture Faculty, University of Muhammadiyah Sumatera Utara street Tuar District of Amplas with altitude of 27 meters above sea level with a factorial randomized block design RAK F with two treatment factors studied were Granting Manure factor K which consists of four levels, namely K0 K1 K2 K3 and Fertilizer factors Giving ABG A which consists of four levels, namely A0 A1 A2 A3 Cow manure treatment showed significant effect on the length of the plant harvest fruit length fruit diameter fruit weight per plant but did not show a marked influence on the observation of the number of fruits per plant ABG fertilizer treatment showed significant effect on the length of the plant fruit length fruit diameter fruit weight per plant but showed no significant effect on harvest age and number of fruits per plant Interaction between cow manure and fertilizer ABG showed a significant effect on plant length fruit length fruit diameter fruit weight per plant harvest number of fruits per plant Keywords cow manure fertilizer ABG growth production cucumber
Supporting PhD Students to Become Faculty in Gerontological Social Work: AGESW's Fellowship Program
Venue: Innovation in Aging
Year: 2020

In the United States, the field of social work faces a critical shortage of students and faculty with expertise in gerontology needed to meet the growing needs of an aging society. To help recruit, train, and retain aging related social work practitioners, researchers, and educators, the Association for Gerontological Education in Social Work (AGESW) created the Pre Dissertation Fellowship Program in 2010. AGESW provides leadership in the areas of gerontological social work education, research, and policy and its PDFP was designed to support doctoral students in their education and future careers. In this 10th anniversary year of the PDFP, this symposium presents multiple perspectives of PDFP program evaluation. The first paper uses qualitative data from eight years of PDFP evaluations to identify types of professional skills attained through the program and areas of professional development missing from PDFP fellows' home doctoral programs. The second paper uses quantitative data from a retrospective survey administered to PDFP alumni to describe their perspectives on the effects of the program. The third paper uses data from a retrospective survey of three cohorts of PDFP alumni to demonstrate the use of social network analysis for program evaluation. The fourth and final paper uses an idiographic approach to explain benefits of the PDFP from the perspectives of early stage scholars who participated in the program. Overall, the symposium provides evidence that suggests the effectiveness of the PDFP in building professional networks, mentoring doctoral students, and teaching academic skills and discusses using the PDFP model in other gerontological fields.
Knowledge of Oral and Maxillofacial Surgery among students and practitioners in Medicine and Dentistry: A Morrocan national survey.
Year: 2017

This study aims to establish the knowledge of the Morrocan Medical and Dental audience regarding Oral and Maxillofacial Surgery OMFS.  A form was randomly sent to more than 5000 doctors, dentists and students in Medicine and Dentistry.  The authors retained 416 filled forms. 98% of the participants declared they know what OMFS is. Less than half of them have received theoretical training in OMFS and less than a quarter have received practical training. Three quarters of the respondents who are involved in patients' daily care don't feel confident in managing OMFS emergencies. Comparison made between groups of trained versus non trained respondents showed that the participants who received theoretical plus practical training were the most confident in their abilities, whereas there was no difference between the respondents who received no training at all and those who received a practical training only.  OMFS specialists have to deploy efforts in promoting their specialty and in increasing the awareness among Medical and Dental professionals and students who clearly identify a lack of training in this field. The way we teach OMFS to Medicine and Dentistry students has to change.
A Study to Improve Education Through Gamification Multimedia in Museum
Year: 2018

The purpose of this paper is to study a game based multimedia design promote museum education. The museum is an important contributor to the social education function, which should build a modernized public cultural service by using modern technology and new environment. The research methodology mainly adapted on three approach. (1) A literature review of the relationship between people and museums, digital media education and game based learning. (2) An observation of the target groups behavioral habit in the in specific British Museums. (3) A summarize of the particularity and the popularity of the group. This paper focuses on three aspects to evaluate the practical significance of the various theoretical results and discussed these theories permeate the game based multimedia design development in the museum.
Tinjauan al Maslahah terhadap pemikiran Ibnu Hazm tentang kebolehan menikah dengan saudara sepersusuan
Year: 2018

Skripsi ini adalah hasil penelitian kepustakaan dengan judul Tinjauan al Maslahah terhadap Pemikiran Ibnu Hazm tentang Kebolehan Menikah dengan Saudara Sepersusuan. Rumusan masalah adalah: Bagaimana pemikiran Ibnu Hazm tentang kebolehan menikah dengan saudara sepersusuan? Bagaimana tinjauan al maslahah terhadap pemikiran Ibnu Hazm tentang kebolehan menikah dengan saudara sepersusuan? Data penelitian yang digunakan penulis adalah berbasis kepustakaan. Penelitian ini menggunakan pendekatan kualitatif yaitu memaparkan data data yang terkait dengan pendapat Ibnu Hazm tentang kebolehan menikah dengan saudara sepersusuan yang ditemukan dalam berbagai literatur dan kesimpulannya diambil melalui logika induktif, yaitu memaparkan masalah masalah yang bersifat khusus kemudian ditarik suatu kesimpulan yang bersifat umum dengan menggunakan pendekatan maslahah. Hasil penelitian menunjukkan bahwa Ibnu Hazm membolehkan pernikahan antar saudara sepersusuan, karena menurut Ibnu Hazm yang disebut sepersusuan atau rada'ah yang menyebabkan mahram adalah antara mulut bayi dan tetek perempuan bertemu secara langsung. Apabila tidak secara sempurna atau tidak langsung, seperti dicampur dengan makanan atau minuman, maka hal itu tidak menyebabkan hubungan nasab dan keharaman perkawinan. Oleh karena itu, tidak menyebabkan keharaman perkawinan. Ditinjau dari sudut pandang al maslahah, pendapat Ibnu Hazm tentang membolehkan adanya pernikahan antara saudara sepersusuan yang disebabkan karena persusuan terpisah ini tidak sesuai dengan nas, meskipun mencoba menjembatani antara alam teks (manqul) dan logika (ra'yu) Pendapat Ibnu Hazm ini dianggap sesuatu yang dilarang, dan dilarangnya pernikahan antara saudara sepersusuan ini termasuk dalam al maslahah al mu'tabarah, yaitu kemaslahatan yang didukung oleh shara' dimana ada dalil khusus atau spesifik yang menjadi dasar bentuk dan jenis kemaslahatan tersebut. Tujuan dalam pembentukan hukum suatu kejadian dapat mendatangkan keuntungan kepada kebanyakan umat manusia. Pendapat ini juga bertentangan dengan prinsip al maslahah, khususnya pada hifz al nasl (memelihara keturunan) Berdasarkan penelitian ini, maka disarankan kepada masyarakat muslim, khususnya di Indonesia, agar berhati hati dalam menyikapi permasalahan rada'ah atau susuan. Karena persusuan merupakan masalah yang sangat urgen serta mempunyai akibat yang sangat erat hubungannya dengan perkawinan, khususnya untuk menjaga kemurnian keturunan.
A SIGN TO SPEECH TRANSLATION SYSTEM USING MATCHER NEURAL NETWORKS
Year: 2018

Sign language translation is an interesting but difficult problem for which neural network techniques seem promising because of their ability to adjust to the user's hand movements, which is not possible to do by most other techniques. However, even using neural networks and artificial sign languages, the translation is hard, and the best known system, that of Fels Hinton (1993) is capable of translating only 66 root signs and their conjugations. This paper improves their results to 395 root signs while preserving a high accuracy (i.e. over 96 in translation. The use of matcher neural networks (Revesz 1989, 1990) and asymmetric Hamming distances are the key sources of improvement.
Agglomeration humide de poudres a reactivite de surface Approche mecanistique de la morphogenese de structures alimentaires agglomerees
Year: 2012

L'agglomeration humide est une etape cruciale dans la technologie de mise en forme des poudres de par son fort impact sur la qualite finale des produits elabores. Malgre son interet lors de l'elaboration de nombreux produits (aliment, pharmaceutique, genie civil, ainsi que les differents modes technologiques (malaxeurs horizontaux, verticaux, a faible ou fort de taux de cisaillement, lit fluidise, elle reste insuffisamment maitrisee de par la difficulte a proposer des diagrammes de fonctionnement operationnels qui couplent les contributions croisees des procedes et des produits. Ce travail de these s'inscrit dans cette problematique et porte sur l'etude des mecanismes d'agglomeration en lien avec les caracteristiques de la formulation et les parametres operatoires. L'identification et la representation du mode d'assemblage des particules au cours de l'operation de mouillage/malaxage est l'un des enjeux central de ce travail. A partir d'experiences menees avec deux types de poudres alimentaires (semoule de ble dur et poudre de lait) l'agglomeration est induite soit par contacts humides en malaxeur a faible taux de cisaillement soit par des collisions entre les particules collantes en lit fluidise. Les mecanismes d'agglomeration humide de la semoule de ble dur developpes dans un malaxeur a faible cisaillement sont decrits selon un processus de morphogenese qui correle la taille des agglomerats a leur texture via une dimension fractale. L'influence des proprietes physicochimiques des liants liquides sur les mecanismes d'agglomeration est etudiee au regard des parametres du modele fractal. L'etude fine des distributions des proprietes hydrotexturales et dimensionnelles des structures agglomerees a permis d'identifier leur " regle " d'agencement association par meme classe hydro texturale et dimensionnelle. Les regimes d'agglomeration en fonction du mode d'apport d'eau (debit faible, debit fort) sont etudies en se basant sur la notion de flux d'atomisation adimensionne. En ce qui concerne l'agglomeration de la poudre de lait en lit fluidise, les mecanismes d'agglomeration sont etudies en suivant l'evolution des tailles et des teneurs en eau des echantillons preleves durant l'operation de mouillage/sechage et par la suite l'etude de l'impact de certaines conditions operatoires et de formulation sur les proprietes des agglomerats finaux et les regimes d'agglomeration. Un lien entre les procedes est discute et ouvre sur une requalification des regimes d'ecoulement granulaire ainsi que de la reactivite de surface des particules.
Aspiration pneumonia and pneumonitis: a spectrum of infectious/noninfectious diseases affecting the lung
Venue: Current opinion in infectious diseases
Year: 2019

Our purpose is to describe aspiration pneumonia/pneumonitis as a spectrum of infectious/noninfectious diseases affecting the lung. We summarize diagnosis, risk factors, treatment, and strategies for prevention of aspiration. Recent findings Aspiration is present in normal individuals, and disease manifestation depends on the chemical characteristics, frequency, and volume of inoculum. Anaerobes, though present, are no longer the predominant microbes isolated in aspiration pneumonia. Targets for preventing aspiration including improved oral hygiene and positional feeding have had mixed results. Patients diagnosed by clinicians with aspiration pneumonia experience greater morbidity and mortality than patients with community acquired pneumonia.  Aspiration pneumonia and pneumonitis are part of the pneumonia continuum and share similarities in pathophysiology, microbiology, and treatment. Modern microbiology demonstrates that the lung is not sterile, and isolates in aspiration pneumonia frequently include aerobes or mixed cultures. Treatment for aspiration pneumonia should include antibiotic coverage for oral anaerobes, aerobes associated with community acquired pneumonia, and resistant organisms depending on appropriate clinical context. Additional studies targeting prevention of aspiration and investigating the increased morbidity and mortality associated with aspiration pneumonia are warranted.
Virtual mechanism approach for dual arm manipulation
Venue: Robotica
Year: 2013

We propose a novel control approach for cooperative dual arm manipulation tasks. Our scheme has three typical features: (1) the task performed by two robots is represented as a motion of a virtual mechanism and the task execution is accomplished by controlling the virtual mechanism; (2) the two arms and the task form a joined kinematic chain; (3) the scheme allows a cooperative dual arm system to perform the task also when robot base is moving. The calculation of the Jacobian matrix of a chained two arm mechanisms is based on a methodology which is using the Jacobian matrices of particular robot mechanisms and their end effector positions and orientations. The proposed algorithm for dual arm manipulation is verified by simulations of two cooperating planar robots and by experiments on a dual arm robot consisting of two KUKA LWR arms.