nils-herrmann/clean_scirepeval huggingface dataset:
Elaboracion de quesito antioqueno reducido en sal, adicionado con Bifidobacterium bifidum y aprovechamiento de este para la elaboracion de queso fundido
Year: 2012

El quesito antioqueno (QA) queso fresco, blando, sin adicion de bacterias, es un alimento importante para la poblacion colombiana. El salado se realiza con NaCl, al 2,1% El consumo superior de 5 g de sodio por persona por dia aumenta la presion sanguinea y genera enfermedades cardiovasculares. El desarrollo de productos que mejoren la salud del consumidor o mitiguen el impacto de enfermedades, es un topico importante para desarrollar nuevos productos. En este proyecto se desarrollo Quesito Antioqueno reducido en sodio, sustituyendo desde 0% hasta 50% el NaCl por KCl, tambien se adiciono Bifidobacterium bifidum, evaluando los dias 1, 12 y 21 de almacenamiento la composicion fisicoquimica, sensorial, textural del queso y la viabilidad de la cepa probiotica para determinar su concentracion en producto. Al finalizar este periodo, el queso se uso como materia prima para elaborar queso fundido untable en el que se evaluo caracteristicas sensoriales, propiedades fisicoquimicas, composicionales y de viscosidad.
Bone Quality in Chronic Kidney Disease: Definitions and Diagnostics
Venue: Current Osteoporosis Reports
Year: 2017

, and pathogenesis of fractures and renal osteodystrophy. role of bone quality in the pathogenesis of fracture susceptibility in chronic kidney disease (CKD) is beginning to be elucidated. Bone quality refers to bone material properties, such as cortical and trabecular microarchitecture, mineralization, turnover, microdamage, and collagen content and structure. Recent data has added to our understanding of the effects of CKD on alterations to bone quality, emerging data on the role of abnormal collagen structure on bone strength, the potential of non invasive methods to inform our knowledge of bone quality, and how we can use these methods to inform strategies that protect against bone loss and fractures. However, more prospective data is required.SummaryCKD is associated with abnormal bone quality and strength which results in high fracture incidence.
Spatial and Temporal Distribution of Bacterioplankton Molecular Ecological Networks in the Yuan River under Different Human Activity Intensity
Venue: Microorganisms
Year: 2021

Bacterioplankton communities play a crucial role in freshwater ecosystem functioning, but it is unknown how co occurrence networks within these communities respond to human activity disturbances. This represents an important knowledge gap because changes in microbial networks could have implications for their functionality and vulnerability to future disturbances. Here, we compare the spatiotemporal and biogeographical patterns of bacterioplankton molecular ecological networks using high throughput sequencing of Illumina HiSeq and multivariate statistical analyses from a subtropical river during wet and dry seasons. Results demonstrated that the lower reaches (high human activity intensity) network had less of an average degree (10.568/18.363) especially during the dry season, when compared with the upper reaches (low human activity intensity) network (10.685/37.552) during the wet and dry seasons, respectively. The latter formed more complexity networks with more modularity (0.622/0.556) than the lower reaches (high human activity intensity) network (0.505/0.41) during the wet and dry seasons, respectively. Bacterioplankton molecular ecological network under high human activity intensity became significantly less robust, which is mainly caused by altering of the environmental conditions and keystone species. Human activity altered the composition of modules but preserved their ecological roles in the network and environmental factors (dissolved organic carbon, temperature, arsenic, oxidation reduction potential and Chao1 index) were the best parameters for explaining the variations in bacterioplankton molecular ecological network structure and modules. Proteobacteria, Actinobacteria and Bacteroidetes were the keystone phylum in shaping the structure and niche differentiations in the network. In addition, the lower reaches (high human activity intensity) reduce the bacterioplankton diversity and ecological niche differentiation, which deterministic processes become more important with increased farmland and constructed land area (especially farmland) with only 35% and 40% of the community variation explained by the neutral community model during the wet season and dry season, respectively. Keystone species in high human activity intensity stress habitats yield intense functional potentials and Bacterioplankton communities harbor keystone taxa in different human activity intensity stress habitats, which may exert their influence on microbiome network composition regardless of abundance. Therefore, human activity plays a crucial role in shaping the structure and function of bacterioplankton molecular ecological networks in subtropical rivers and understanding the mechanisms of this process can provide important information about human water interaction processes, sustainable uses of freshwater as well as watershed management and conservation.
RNA aptamer driven ECL biosensing for tracing histone acetylation based on nano prism substrate and cascade DNA amplification strategy
Year: 2020

A new RNA aptamer involved electrochemiluminescence (ECL) strategy for sensitive detection of histone acetyltransferase (HAT p300) is designed well based on coenzyme A (CoA) initiated competitive response and advanced DNA nano biotechnology. For the first time, this interesting analytical process is comprised of significant histone acetylation catalyzed by HAT p300, competitive replacement triggered by the specific binding of CoA and its RNA aptamer, stable scaffold guided by DNA nano prism and typical amplification managed by hybrid chain reaction (HCR) Upon recognition of the RNA aptamer to CoA generated in acetylation, auxiliary DNA (A DNA) which can be captured by three hanging arms of the fabricated DNA nano prism immobilized onto Au electrode surface is released from the aptamer/A DNA complex. Moreover, A DNA can also open skillfully one hairpin DNA (H1) then turning into HCR process by alternating hybridization with the other hairpin DNA (H2) Abundant Ru(phen)32+ molecules which have a strong interaction with dsDNA can result in a significant output. This proposed platform exhibits excellent specificity and sensitivity toward HAT p300 with a detection limit of 0.001 nM and takes on outstanding practicality and superiority, which presents a great potential for HAT p300 analysis in biomedical sciences.
An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge.
Venue: MedChemComm
Year: 2018

Molecular dynamics (MD) has become increasingly popular due to the development of hardware and software solutions and the improvement in algorithms, which allowed researchers to scale up calculations in order to speed them up. MD simulations are usually used to address protein folding issues or protein ligand complex stability through energy profile analysis over time. In recent years, the development of new tools able to deeply explore a potential energy surface (PES) has allowed researchers to focus on the dynamic nature of the binding recognition process and binding induced protein conformational changes. Moreover, modern approaches have been demonstrated to be effective and reliable in calculating some kinetic and thermodynamic parameters behind the host guest recognition process. Starting from all of these considerations, several efforts have been made in order to integrate MD within the virtual screening process in drug discovery. Knowledge retrieved from MD can, in fact, be exploited as a starting point to build pharmacophores or docking constraints in the early stage of the screening campaign as well as to define key features, in order to unravel hidden binding modes and help the optimisation of the molecular structure of a lead compound. Based on these outcomes, researchers are nowadays using MD as an invaluable tool to discover and target previously considered undruggable binding sites, including protein protein interactions and allosteric sites on a protein surface. As a matter of fact, the use of MD has been recognised as vital to the discovery of selective protein protein interaction modulators. The use of a dynamic overview on how the host guest recognition occurs and of the relative conformational modifications induced allows researchers to optimise small molecules and small peptides capable of tightly interacting within the cleft between two proteins. In this review, we aim to present the most recent applications of MD as an integrated tool to be used in the rational design of small molecules or small peptides able to modulate undruggable targets, such as allosteric sites and protein protein interactions.
Design for a UWB Down Conversion Mixer for Multi Band Applications
Venue: ICWMC 2013
Year: 2013

In this paper, a CMOS down conversion mixer for UWB applications is presented. The mixer circuit is designed using a VIS 0.25mm RF CMOS technology, working at the 0.9GHz 10.6GHz frequency range; it will be used in applications such as IEEE WiFi, GSM and WiMAX. The core of the mixer has been designed based on double balanced cell architecture, and uses the current bleeding method to increase the linearity and improve the conversion gain. We put a resistor on the drain of the MOS between two RF inputs, which will improve the flatness of conversion gain. Regarding the arrangement of the mixer, the RF frequency is set at 0.9GHz 10.6GHz, the LO frequency 0.8GHz 10.5GHz and the IF of 100MHz. The simulated conversion gain of the mixer is 7+ 1dB. The 1dB compression point is higher than 11dBm at high frequency and 9dBm at low frequency. The RF input return loss is well below 11dB, and the LO input return loss is below 10dB. The noise figure is 12.93dB while IF is 100MHz, and the mixer core dissipates 9.8mW under a 1.8 V supply.
On John Miller's 'The Korean Film Industry' The Asia Foundation, KMPCA, and Korean cinema, 1956
Year: 2015

John Miller, former Hollywood producer and The Asia Foundation's special motion picture officer in Tokyo, spent six months in Korea in 1956. His mission, as a motion picture advisor, was to assist the newly launched Korean Motion Picture Cultural Association (KMPCA) Upon completion of his duty in Korea, Miller composed an exhaustive project report entitled 'The Korean Film Industry' It was, as Miller himself wrote, 'the first study of its kind made by either a Korean or a foreigner' This significant historical record has been forgotten since then. Thanks to The Asia Foundation headquarters' permission, however, Miller's valuable report is finally available to interested readers, students and scholars in the field of Korean cinema.
Procede de liaison de rainure de soudage, procede de soudage a deux fils et systeme associe
Year: 2010

Un procede de liaison de rainure de soudage consiste a pre relier un profile superieur (1) et un profile inferieur (2) pour former une rainure de soudage predefinie, a juger si la rainure de soudage predefinie bloque le soudage d'un pistolet a souder (4) lorsque le soudage est bloque, a marquer une ligne de liaison formee par la pre liaison des profiles superieur et inferieur sur le profile superieur (1) a separer le profile superieur (1) et le profile inferieur (2) l'un de l'autre, a traiter le profil superieur (1) le long de la ligne de liaison en fonction de la rainure de soudage predefinie, et a relier le profile inferieur (2) au profil superieur traite (3) pour former la rainure de soudage. Un procede de soudage a deux fils et un systeme de soudage a deux fils comprennent une plage d'angle de suivi d'un capteur de suivi (5) en fonction d'un angle de rainure, a regler un angle de soudage du pistolet a souder (4) en fonction de l'angle de rainure, a verifier si l'angle de soudage est correct le long de la rainure de soudage sous le guidage du capteur de suivi (5) lorsque l'angle de soudage est correct, a commander le pistolet a souder (4) pour commencer l'arc, et a realiser le soudage le long du chemin de soudage en fonction de l'angle de soudage verifie. La presente invention surmonte le defaut technique de la technique de l'art selon lequel la rainure de soudage n'est pas pratique a souder pour le pistolet a souder lorsque l'angle de rainure de soudage est environ a angle droit ou a angle aigu.
Novel Trace Based Construction of the Parallel In Serial Out Multiplication for Elliptic Curve Digital Signature Algorithm Like Binary Extension Fields
Venue: 2019 IEEE 9th Annual Computing and Communication Workshop and Conference (CCWC)
Year: 2019

The Gaussian normal bases (GNBs) recommended by the National Institute of Standards and Technology (NIST) for the five binary extension fields of the Elliptic Curve Digital Signature Algorithm (ECDSA) are self dual. Multiplication, is a complex, and critical, field operation for the hardware oriented implementations of field inversion an important operation in the elliptic curve based algorithms in the GNB representation. This paper, introduces a novel construction for the bit serial parallel in serial out (BS PISO) multiplication over the "NIST like" fields, based on the Trace mapping. The new formulations, are presented for the first time in literature as far as we know, and provide a new and simple understanding of the Trace based mathematical model behind such a BS PISO multiplication. In addition, derivation of existing formulations for the PISO GNB field multiplication, based on the new Trace based construction, is presented. A digit serial most significant digit first PISO field multiplication architecture is constructed, based on the new Trace based BS PISO formulations, and the corresponding theoretical space and time complexities are derived and compared to other counterparts. Moreover, post synthesis space and time readings are reported, based on Application specific integrated circuit (ASIC) realizations, using the NANGate 45nm open cell libraries.
Contabilidad Ambiental: Desde una Vision de Responsabilidad Social
Year: 2020

Es evidente un movimiento mundial relacionado con la proteccion de los bienes naturales del planeta. En este escenario aparece la Contabilidad Ambiental requerida en la composicion de datos y fuente de recoleccion, medicion y divulgacion de transacciones ambientales que juegan un papel relevante como canal de dialogo entre la empresa y la sociedad. El proposito de este estudio es investigar como las organizaciones que figuran en el indice de sostenibilidad corporativa (ISE) BM FBOVESPA estan informando su informacion sobre el cambio climatico y el mercado de carbono, y como se divulgan en relacion con los antecedentes de la ciencia contable. Se utilizo una investigacion documental descriptiva, con tratamiento cuantitativo. Con este fin, se examinaron los estados financieros de quince entidades que cooperaron con empresas de cambio climatico. La informacion del estudio se recopilo en los sitios web de BM FBOVESPA y las empresas, obteniendo una muestra seleccionada en el ano fiscal 2018. Siguiendo un plan creado de acuerdo con el Estandar Tecnico de Contabilidad de Brasil numero 15 (NBC T15) observamos la peculiaridad de los datos. revelado por las instituciones analizadas segun lo definido en el estandar. Se encontro relevancia ambiental, sin embargo, solo siete empresas presentaron en el balance sus informes ambientales. Otra informacion se evidencio en las notas explicativas, que muestran que las entidades aun no aprovechan la gestion contable y ambiental como mecanismos indispensables e influyentes en el medio ambiente.
Indications and limitations of the use of subjective global assessment in clinical practice: an update
Venue: Current opinion in clinical nutrition and metabolic care
Year: 2006

global assessment is a clinical tool for assessing nutritional status that merges alterations in body composition and physiological function. Although it was first described almost two decades ago, many studies using this method have been published during the past few years. This review describes recent findings from such studies. Recent findingsSubjective global assessment has proved to be a good nutritional assessment and prognostic indicator in several clinical situations. Agreement between subjective global assessment and newer screening methods is not always acceptable, and it has not been validated with respect to clinical outcome. Some modifications have been suggested that may increase the sensitivity of subjective global assessment as a screening tool. A scored version of subjective global assessment for cancer patients is now being validated for use in other patient groups. This could increase its utility in nutritional intervention studies if it can be demonstrated that subtle changes in nutritional status are reflected by numerical scores in patient generated subjective global assessment. SummarySubjective global assessment represents a good option for assessing nutritional status in various clinical situations. As a screening tool, it better identifies established malnutrition than nutritional risk but its sensitivity is suboptimal. The scored version of subjective global assessment may have advantages and extend the usefulness of this tool even further.
Using Wikipedia to Translate OOV Term on MLIR
Venue: NTCIR
Year: 2007

We deal with Chinese, Japanese and Korean multilingual information retrieval (MLIR) in NTCIR 6, and submit our results on the C CJK T and C CJK D subtask. In these runs, we adopt Dictionary Based Approach to translate query terms. In addition to tradition dictionary, we incorporate the Wikipedia as a live dictionary.
MOD: Minimally Ordered Durable Datastructures for Persistent Memory
Venue: ASPLOS
Year: 2020

Persistent Memory (PM) makes possible recoverable applications that can preserve application progress across system reboots and power failures. Actual recoverability requires careful ordering of cacheline flushes, currently done in two extreme ways. On one hand, expert programmers have reasoned deeply about consistency and durability to create applications centered on a single custom crafted durable datastructure. On the other hand, less expert programmers have used software transaction memory (STM) to make atomic one or more updates, albeit at a significant performance cost due largely to ordered log updates. In this work, we propose the middle ground of composable persistent datastructures called Minimally Ordered Durable datastructures (MOD) We prototype MOD as a library of C+ datastructures currently, map, set, stack, queue and vector that often perform better than STM and yet are relatively easy to use. They allow multiple updates to one or more datastructures to be atomic with respect to failure. Moreover, we provide a recipe to create additional recoverable datastructures. MOD is motivated by our analysis of real Intel Optane PM hardware showing that allowing unordered, overlapping flushes significantly improves performance. MOD reduces ordering by adapting existing techniques for out of place updates (like shadow paging) with space reducing structural sharing (from functional programming) MOD exposes a Basic interface for single updates and a Composition interface for atomically performing multiple updates. Relative to widely used Intel PMDK v1.5 STM, MOD improves map, set, stack, queue microbenchmark performance by 40% and speeds up application benchmark performance by 38%
UPI Net: Semantic Contour Detection in Placental Ultrasound
Venue: 2019 IEEE/CVF International Conference on Computer Vision Workshop (ICCVW)
Year: 2019

Semantic contour detection is a challenging problem that is often met in medical imaging, of which placental image analysis is a particular example. In this paper, we investigate utero placental interface (UPI) detection in 2D placental ultrasound images by formulating it as a semantic contour detection problem. As opposed to natural images, placental ultrasound images contain specific anatomical structures thus have unique geometry. We argue it would be beneficial for UPI detectors to incorporate global context modelling in order to reduce unwanted false positive UPI predictions. Our approach, namely UPI Net, aims to capture long range dependencies in placenta geometry through lightweight global context modelling and effective multi scale feature aggregation. We perform a subject level 10 fold nested cross validation on a placental ultrasound database (4,871 images with labelled UPI from 49 scans) Experimental results demonstrate that, without introducing considerable computational overhead, UPI Net yields the highest performance in terms of standard contour detection metrics, compared to other competitive benchmarks.
[Resistance to the latest beta lactams: mechanisms of acquisition and spread of resistance in Enterobacteriaceae]
Venue: Bulletin de l'Academie nationale de medecine
Year: 2007

Resistance to antibiotics may drastically diminish the efficacy of therapy in some clinical circumstances. The emergence of Enterobacteriaceae (Klebsiella pneumoniae, Aerobacter aerogenes, Escherichia coli) resistant to the more recent beta lactam agents (cefepime, cefpirome, azthreonam and carbapenems) generally results from misuse of antibiotics, leading to the selection of preexisting resistant mutants. Resistance is usually due to beta lactamase expression, through: mutations involving the beta lactamase structure (TEM, SHV, OXA, CTX M beta lactamase families) and/or mutations of beta lactamase synthesis regulators (AmpC beta lactamases) or the appearance of new enzymes (PER, VEB, CMY, DHA 1, ACC 1, etc. The level of resistance (particularly to carbapenems) is increased when porin mutations are associated with beta lactamase expression. The spread of these new resistance mechanisms is amplified by mobilisation of resistance genes from the chromosome to a plasmid (SHV, CTX M, CMY DHA 1 beta lactamases genes) and by the location of these genes in mobile elements (integrons and transposons) The recent appearance of these mechanisms (particularly CTX M beta lactamases) in strains circulating in the community is a matter of concern.
The altered gut microbiota of high purine induced hyperuricemia rats and its correlation with hyperuricemia
Venue: PeerJ
Year: 2020

Some studies on the hyperuricemia (HUA) have focused on intestinal bacteria. To better understand the correlation between gut microbiota and HUA, we established a HUA rat model with high purine diet, and used 16S rRNA genes sequencing to analyze gut microbiota changes in HUA rats. To analyze the potential role played by gut microbiota in HUA, we altered the gut microbiota of HUA rats with antibiotics, and compared the degree of uric acid elevation between HUA and antibiotic fed HUA rats (Ab+HUA) Finally, we established a recipient rat model, in which we transplanted fecal microbiota of HUA and normal rats into recipient rats. Three weeks later, we compared the uric acid content of recipient rats. As a result, the diversity and abundance of the gut microbiota had changed in HUA rats. The Ab fed HUA rats had significantly lower uric acid content compared to the HUA rats, and gut microbiota from HUA rats increased uric acid content of recipient rats. The genera Vallitalea, Christensenella and Insolitispirillum may associate with HUA. Our findings highlight the association between gut microbiota and HUA, and the potential role played by gut microbiota in HUA. We hope that this finding will promote the isolation and culture of HUA related bacteria and orient HUA related studies from being correlational to mechanistic. These steps will therefore make it possible for us to treat HUA using gut microbiota as the target.