nils-herrmann/clean_scirepeval huggingface dataset:
Abstract 2081: Robust activity of BLU 285, a potent and highly selective inhibitor of mutant KIT and PDGFRa, in patient derived xenograft (PDX) models of gastrointestinal stromal tumor (GIST)
Year: 2017

Patients with advanced and treatment resistant GIST are treated with tyrosine kinase inhibitors (TKI) such as imatinib (IMA) sunitinib (SUN) or regorafenib (REG) Resistance to these TKI is mainly caused by the emergence of on target secondary KIT mutations in exons 13 and 17. We tested the activity of BLU 285 (Blueprint Medicines) a potent and highly selective inhibitor of mutant KIT and PDGFRa, in three PDX models of primary and refractory GIST that respond differently to the approved TKI used in the treatment of GIST.  NMRI nu/nu mice (n=93) were transplanted bilaterally with human xenografts UZLX GIST3 (KIT: exon 11 p.W557_V559delinsF; IMA sensitive) GIST2B (KIT: exon 9 p.A502_Y503dup, IMA dose dependent sensitive) and GIST9 (KIT: exon 11 p.P577del; W557LfsX5; exon 17 D820G; IMA and SUN resistant) We performed the following experimental comparisons: BLU 285 (10, 30 and 100 mg/kg/qd) vs. control and IMA (50 mg/kg/bid) [GIST3] BLU 285 (10, 30 and 60 mg/kg/qd) vs. control and IMA (50 and 100 mg/kg/bid or SUN 40 mg/kg/qd) [GIST2B] and BLU 285 (10 and 30 mg/kg/qd) vs. control, IMA (50 mg/kg/bid) or REG (30 mg/kg/qd) [GIST9] Animals were dosed orally for 16 days. Activity was assessed by tumor volume measurement, histopathology and Western blotting of the KIT signaling pathway (WB) Mann Whitney U test was used for statistical analysis.  Yemarshet K. Gebreyohannes, Agnieszka Wozniak, Madelina Elena Zhai, Jasmien Wellens, Jasmien Cornillie, Erica Evans, Alexandra K Gardino, Christoph Lengauer, Maria Debiec Rychter, Raf Sciot, Patrick Schoffski. Robust activity of BLU 285, a potent and highly selective inhibitor of mutant KIT and PDGFRa, in patient derived xenograft (PDX) models of gastrointestinal stromal tumor (GIST)   2017; 2017 Apr 1 5; Washington, DC. Philadelphia (PA) AACR;  doi:10.1158/1538 7445.AM2017 2081
Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking based virtual screening and fluorescence based inhibition assays.
Venue: Food function
Year: 2020

Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50% 80% of patients receiving this anticancer agent. Herbal medicines are frequently used for the prevention and treatment of the intestinal toxicity of irinotecan, but it is very hard to find strong hCES2A inhibitors from herbal medicines in an efficient way. Herein, an integrated strategy via combination of chemical profiling, docking based virtual screening and fluorescence based high throughput inhibitor screening assays was utilized. Following the screening of a total of 73 herbal products, licorice (the dried root of Glycyrrhiza species) was found with the most potent hCES2A inhibition activity. Further investigation revealed that the chalcones and several flavonols in licorice displayed strong hCES2A inhibition activities, while isoliquiritigenin, echinatin, naringenin, gancaonin I and glycycoumarin exhibited moderate inhibition of hCES2A. Inhibition kinetic analysis demonstrated that licochalcone A, licochalcone C, licochalcone D and isolicoflavonol potently inhibited hCES2A mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 mM. Further investigations demonstrated that licochalcone C, the most potent hCES2A inhibitor identified from licorice, dose dependently inhibited intracellular hCES2A in living HepG2 cells. In summary, this study proposed an integrated strategy to find hCES2A inhibitors from herbal medicines, and our findings suggested that the chalcones and isolicoflavonol in licorice were the key ingredients responsible for hCES2A inhibition, which would be very helpful to develop new herbal remedies or drugs for ameliorating hCES2A associated drug toxicity.
DOBLE JORNADA DE TRABAJO Y CALIDAD DE VIDA DE LAS MUJERES QUE LABORAN EN LA SECRETARIA DE ADMINISTRACION DEL GOBIERNO DEL ESTADO DE OAXACA. UN ESTUDIO DESDE LA PERSPECTIVA DE GENERO.
Year: 2016

En la actualidad, uno de los problemas primordiales relacionados al desarrollo regional con enfoque de genero, es el referido a la situacion de trabajo de las mujeres, por un lado en terminos de la participacion del trabajo laboral asalariado (ambito publico) y por el otro lado, el trabajo que se realiza en casa sin ninguna remuneracion (ambito privado) denominado para esta investigacion Doble Jornada de Trabajo. En donde al conjuntar ambos planteamientos la carga de trabajo representa un interesante tema a explorar de tal forma que el presente escrito, tiene por objeto estudiar la relacion que existe entre la Doble Jornada de Trabajo y la Calidad de Vida de las mujeres desde la perspectiva de genero. El fundamento Teorico abarca aspectos como la Teoria de Genero, que incluye la Doble jornada de trabajo y la calidad de vida de las mujeres, lo cual permite fundamentar y explicar el modelo teorico. El estudio fue realizado bajo el metodo cuantitativo de investigacion en donde con base al analisis estadistico las variables Doble Jornada de Trabajo y Calidad de Vida se sometieron a un proceso de correlacion para comprobar la hipotesis la cual fue aceptada como una "correlacion positiva media" Lo cual indica que la Doble jornada de trabajo influye en la calidad de vida de las mujeres en dicha institucion.
The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months
Venue: PLoS biology
Year: 2019

1 Public Library of Science, San Francisco, California, United States of America, 2 Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 3 CRCINA,  CNRS, Universite d'Angers, Universite de Nantes, Nantes, France, 4 Department of Biology, Lund University, Lund, Sweden, 5 Department of Biology Howard Hughes Medical Institute Graduate Program in  New Jersey, United States of America, 9 Center for Infectious Disease Dynamics, Departments of Biology and Entomology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, 10 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 11 Section of Cell and Developmental Biology and Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America, 12 MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom, 13 Studies of Translation, Ethics, and Medicine, Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada
Computational exploration of a redox neutral organocatalytic Mitsunobu reaction.
Venue: Journal of the American Chemical Society
Year: 2020

The mechanism of the redox neutral organocatalytic Mitsunobu reac tion, catalyzed by (2 hydroxybenzyl)diphenylphosphine oxide, re ported by Denton et al. has been studied computationally with oB97X D density functional theory. We discovered that the nucleo philic substitution reaction between carboxylate and alkoxyphospho nium ions, to reform the phosphine oxide catalyst, is the rate determining step of the overall process and is significantly accelerated compared with a general acid catalyzed SN2 reaction. The (2 hydroxybenzyl)diphenylphosphine oxide is regenerated and activated in every catalytic cycle via intramolecular dehydration/cyclization. We also designed several phosphine oxide catalysts that we predict to be more effective catalysts.
Integrated management of postharvest gray mold on fruit crops
Year: 2016

Gray mold, incited by Botrytis cinerea causes major postharvest losses in a wide range of crops. Some infections that occur in the field remain quiescent during the growing season and develop after harvest. The pathogen is also capable of infecting plant tissues through surface injuries inflicted during harvesting and subsequent handling; these develop during storage, even at 0 degC, and spread among products by aerial mycelial growth and conidia. The postharvest decay by this pathogen is controlled by a combination of preharvest and postharvest practices. To minimize postharvest gray mold, control programs rely mainly on applications of fungicides. However, mounting concerns of consumers and regulatory authorities about risks associated with chemical residues in food have led to imposition of strict regulations, the banning of use of certain chemical groups, and preferences by wholesaler, retailers and consumers to avoid chemically treated produce. These developments have driven the search for alternative management strategies that are effective and not reliant on conventional fungicide applications. In this review, conventional and alternative control strategies are discussed including their advantages and disadvantages. They include the use of conventional fungicides, biocontrol agents, physical treatments, natural antimicrobials, and disinfecting agents. Based on examples to control gray mold on specific crops, it is concluded that an integrated management program where adoption of a holistic approach is the key for meeting the challenge of minimizing postharvest losses caused by B. cinerea To optimize the efficacy of treatments, it is essential to understand their mechanism of action as much as possible. Information about direct and indirect effects of each approach on the pathogen is also presented.
Internet of Things and LoRa(tm) Low Power Wide Area Networks: A survey
Venue: 2017 International Symposium on Signals, Circuits and Systems (ISSCS)
Year: 2017

Nowadays there is a lot of effort on the study, analysis and finding of new solutions related to high density sensor networks used as part of the IoT (Internet of Things) concept. LoRa (Long Range) is a modulation technique that enables the long range transfer of information with a low transfer rate. This paper presents a review of the challenges and the obstacles of IoT concept with emphasis on the LoRa technology. A LoRaWAN network (Long Range Network Protocol) is of the Low Power Wide Area Network (LPWAN) type and encompasses battery powered devices that ensure bidirectional communication. The main contribution of the paper is the evaluation of the LoRa technology considering the requirements of IoT. After introduction in Section II the main obstacles of IoT development are discussed, section III addresses the challenges and entails the need for solutions to different problems in WSN research. Section IV presents the LoRaWAN communication protocol architecture requirements while in Section V the LoRa modulation performance is evaluated and discussed. In conclusion LoRa can be considered a good candidate in addressing the IoT challenges.
Review of software tools for hybrid renewable energy systems
Year: 2014

Hybrid energy systems are being utilized for supplying electrical energy in urban, rural and remote areas to overcome the intermittence of solar and wind resources. A hybrid renewable energy system incorporates two or more electricity generation options based on renewable energy or fossil fuel unit. The techno economic analysis of the hybrid system is essential for the efficient utilization of renewable energy resources. Due to multiple generation systems, hybrid system analysis, is quite complex and requires to be analyzed thoroughly. This requires software tools for the design, analysis, optimization, and economic viability of the systems. In this paper, 19 softwares with their main features and current status are presented. The softwares studied are HOMER, Hybrid2, RETScreen, iHOGA, INSEL, TRNSYS, iGRHYSO, HYBRIDS, RAPSIM, SOMES, SOLSTOR, HySim, HybSim, IPSYS, HySys, Dymola/Modelica, ARES, SOLSIM, and HYBRID DESIGNER. The research work related to hybrid systems carried out using these softwares at different locations worldwide is also reviewed. The main objective of the paper is to provide the current status of these softwares to provide basic insight for a researcher to identify and utilize suitable tool for research and development studies of hybrid systems. The capabilities of different softwares are also highlighted. The limitations, availability and areas of further research have also been identified.
Versatile Strategy for Tuning ORR Activity of a Single Fe N4 Site by Controlling Electron Withdrawing/Donating Properties of a Carbon Plane.
Venue: Journal of the American Chemical Society
Year: 2019

Replacement of Pt based oxygen reduction reaction (ORR) catalysts with non precious metal catalysts (NPMCs) such as Fe/N/C is one of the most important issues in the commercialization of proton exchange membrane fuel cells (PEMFCs) Despite numerous studies on Fe/N/C catalysts, a fundamental study on the development of a versatile strategy is still required for tuning the kinetic activity of a single Fe N4 site. Herein, we report a new and intuitive design strategy for tuning and enhancing the kinetic activity of a single Fe N4 site by controlling electron withdrawing/donating properties of a carbon plane with the incorporation of sulfur functionalities. The effect of electron withdrawing/donating functionalities was elucidated by experimentation and theoretical calculations. Finally, the introduction of an oxidized sulfur functionality decreases the d band center of iron by withdrawing electrons, thereby facilitating ORR at the Fe N4 site by lowering the intermediate adsorption energy. Furthermore, this strategy can enhance ORR activity without a decrease in the stability of the catalyst. This simple and straightforward approach can be a cornerstone to develop optimum NPMCs for application in the cathodes of PEMFCs.
Effect of bed size on the gas solid flow characterized by pressure fluctuations in bubbling fluidized beds
Year: 2019

Pressure fluctuations in four bubbling fluidized beds having different bed sizes (three square cross sections of 5, 10, and 15 cm in side length, and one rectangular cross section of 2 x 10 cm2) were measured at four axial positions (P1, P2, P3, and P4) Several characteristic indicators of the flow specifically of the pressure were calculated. In terms of these characteristic indicators, the effect of bed size on flow behavior was investigated. The results show that in the fully fluidized state, the pressure drop is slightly higher in smaller beds, but the pressure drops in the 10 and 15 cm beds are close. The 15 cm bed has the lowest pressure fluctuation amplitude. The amplitudes at P1 and P2 in the lower part of the bed are very close for bed sizes below 10 cm, but the amplitude at P3 near the bed surface increases with decreasing bed size. No general trend was observed regarding the effect of bed size on skewness and kurtosis of the pressure for all four axial heights. For the average, standard deviation, skewness, and kurtosis of the pressure at P4, the values are close for the two small beds (2 x 10 and 5 x 5 cm2) and the two large beds (10 x 10 and 15 x 15 cm2) and hence the effect of bed size separates the beds into two groups. In the fully fluidized state, for P1, P2, and P3, the Kolmogorov entropy and the dominant frequency both increase with increasing bed size, but in the pseudo 2D bed both are between the values for the 5 and 10 cm beds.
A Discretization Algorithm Based on Extended Gini Criterion
Year: 2012

A supervised, global and static algorithm for the discretization of continuous features is presented in this paper. The proposed discretization algorithm extends Gini criterion concept. The algorithm hybridizes binning, and entropy method based on the amendment from 1R and Ent Minimum Description Length Principle (MDLP) method. The proposed algorithm is comparable due to its simplicity, yet need further improvement and testing using various data sets. The proposed algorithm can be a good alternative method in the entropy based discretization family.
Improving trust in context aware applications with intelligibility
Venue: UbiComp '10 Adjunct
Year: 2010

Since context aware applications use implicit sensing and increasingly complex decision making, they may make mistakes or users may misunderstand their actions. This may hinder trust and adoption of context aware applications. We hypothesize that making these applications intelligible by explaining themselves to users would help counter this lack of trust. The proposed thesis would contribute to context aware computing by (i) understanding the need to explain these applications to users, (ii) understanding the benefits and trade offs of providing intelligibility, and (iii) providing toolkit support intelligibility to ultimately improve the trust, adoption of, and sustained use context aware systems.
A Home Automation System Based on Bluetooth Technology Using an Android Smartphone
Year: 2020

In this work, a simple home automation system is to be discussed and designed. It is a concept where devices can be controlled remotely from a central hub and also allow these devices share data. It is proposed to design and build a system for home automation using Bluetooth technology. The reason Bluetooth is being used is because, it is an easily accessible network, thereby making it cheap. The implementation process will involve a software design for the android smartphone and a circuit design for the operation of the devices. An Arduino microcontroller will be used to control the circuit, and an android smartphone will be used as the control hub. Both will be linked by a Bluetooth module. At the end of the exercise, an active system for the control of basic home appliances will be developed, having an easy to use UI "user interface." In the introduction, the background of the study will be discussed.
Humanistic Psychology and Introductory Textbooks: A 21st Century Reassessment
Year: 2017

Twenty one current introductory psychology textbooks were analyzed to assess the quantity and quality of their presentations of humanistic psychology and related concepts and approaches, such as existential and phenomenological perspectives. Results indicated that coverage of humanistic approaches constitutes an extremely small portion of the field as a whole and is limited almost exclusively to the areas of motivation, personality, and psychotherapy. Coverage is also overwhelmingly limited to the contributions of Abraham Maslow and Carl Rogers, with only occasional, passing inclusion of other important humanistic themes, concepts, or figures of either historical or contemporary note and little representation of existential and phenomenological perspectives. Further, the humanistic approach is frequently characterized explicitly as unscientific and naively overoptimistic, whereas more implicit critiques suggest it is an outdated approach rooted deeply in the culture of the 1960s and perhaps more a form of philosophy or spirituality than psychology or science. The importance of improving both the quantity and quality of coverage of humanistic psychology as well as the challenges inherent in securing improved representation are also discussed.
Fecal Microbiota Transplantation Inhibits Multidrug Resistant Gut Pathogens: Preliminary Report Performed in an Immunocompromised Host
Venue: Archivum Immunologiae et Therapiae Experimentalis
Year: 2016

AbstractColonization of the gastrointestinal tract with multidrug resistant (MDR) bacteria is a consequence of gut dysbiosis. We describe the successful utilization of fecal microbiota transplantation to inhibit Klebsiella pneumoniae MBL+ and Escherichia coli ESBL+ gut colonization in the immunocompromised host as a novel tool in the battle against MDR microorganisms.
As time goes by maintaining longitudinal satisfaction: a perspective of hedonic adaptation
Year: 2016

The purpose of this paper is to improve our understanding of how firms can maintain longitudinal satisfaction. Previous research on longitudinal satisfaction demonstrates that the product attributes weight on satisfaction shifts over time. However, the existing literature lacks an understanding of the intervening mechanism. Inspired by the hedonic adaptation theory, this research first argues that the shift depends on the attribute's variability. Then, it posits that hedonic adaptation might play a mediation role in connecting the attribute's weight and longitudinal satisfaction. Finally, the research incorporates consumer intentional activities into the antecedents of longitudinal satisfaction.  The authors test a series of hypotheses across two studies. Using the Slope shift Parameter Theory and Structural Equation Modeling, data collected from smartphone owners in four MBA classes (Study 1) and eight business venues in China (Study 2) are analyzed to confirm the research model.  The findings suggest that hedonic adaptation occurs during the ownership process. It is revealed that both the attribute's variability and consumption behavior play important roles in sustaining long term satisfaction, confirming the mediating effects of hedonic adaptation on the relationship above.  The hedonic adaptation theory is applied to study the mediating role of product attribute variability and consumption behavior in sustaining customer satisfaction over time. Three contributions are offered: First, hedonic adaptation occurs during the ownership process; second, the attribute's variability and consumption behavior both play important roles in sustaining longitudinal satisfaction; third, the mediating effects of hedonic adaptation are confirmed for the relationship between attribute's variability and sustaining satisfaction and consumption behavior and sustaining satisfaction.