nils-herrmann/clean_scirepeval huggingface dataset:
Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1
Venue: Oncology reports
Year: 2020

Colorectal cancer (CRC) is the third most common tumor in the world; however, the role and mechanism of endoplasmic reticulum (ER) stress in CRC metastasis remains largely unclear. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is a long non coding RNA (lncRNA) which has previously been associated with CRC metastasis. It has been suggested that ER stress pathways regulate lncRNA expression; however, the effect of ER stress on MALAT1 expression in cancer is unknown. The present study aimed to investigate the relationship between ER stress pathways, MALAT1 expression and cell migration in CRC cells. ER stress was induced by thapsigargin (TG) low dose TG induced the migration of HT29 and HCT116 cells, but not SW1116 and SW620 cells. This effect was associated with increased expression levels of MALAT1, as the knockdown of MALAT1 prevented TG induced cell migration. TG induced MALAT1 expression was associated with inositol requiring enzyme 1 (IRE1) expression and activation of the protein kinase R (PKR) like ER kinase (PERK) signaling pathway. X box binding protein 1 (XBP1) and activating transcription factor 4 (ATF4) binding sites were predicted to be located in the MALAT1 gene promoter regions and the expression of MALAT1 was positively associated with XBP1 and ATF4 expression levels in CRC tissue samples. Thus, these findings indicated that ER stress may promote the migration of CRC cells and contribute to the progression of CRC through the activation of the IRE1/XBP1 and PERK/eIF2a/ATF4 signaling pathways. In conclusion, to the best of our knowledge, this study is the first report that lncRNA MALAT1 expression is regulated by the IRE1/XBP1 pathway in CRC.
Fault Parameter Constraints Using Relocated Earthquakes: A Validation of First Motion Focal Mechanism Data
Year: 2006

We estimate the strike and dip of three California fault segments (Calaveras, Sargent, and a portion of the San Andreas near San Jaun Bautistia) based on principle component analysis of accurately located microearthquakes. We compare these fault orientations with two different first motion focal mechanism catalogs: the Northern California Earthquake Data Center (ncedc) catalog, calculated using the fpfit algorithm (Reasenberg and Oppenheimer, 1985) and a catalog created using the hash algorithm that tests mechanism stability relative to seismic velocity model variations and earthquake location (Hardebeck and Shearer, 2002) We assume any disagreement (misfit >30deg in strike, dip, or rake) indicates inaccurate focal mechanisms in the catalogs. With this assumption, we can quantify the parameters that identify the most optimally constrained focal mechanisms. For the ncedc/fpfit catalogs, we find that the best quantitative discriminator of quality focal mechanisms is the station distribution ratio (stdr) parameter, an indicator of how the stations are distributed about the focal sphere. Requiring stdr 0.65 increases the acceptable mechanisms from 34% 37% to 63% 68% This suggests stations should be uniformly distributed surrounding, rather than aligning, known fault traces. For the hash catalogs, the fault plane uncertainty (fpu) parameter is the best discriminator, increasing the percent of acceptable mechanisms from 63% 78% to 81% 83% when fpu 35deg. The overall higher percentage of acceptable mechanisms and the usefulness of the formal uncertainty in identifying quality mechanisms validate the hash approach of testing for mechanism stability.  3D visualization of relocated earthquakes and accuracy of focal mechanisms.
The behavior of TIG welding arc in a high frequency axial magnetic field
Venue: Welding in the World
Year: 2020

The effect of high frequency axial magnetic field (HFAMF) on the shape of the welding arc and welding formation of tungsten inert gas (TIG) welding is analyzed theoretically and experimentally. The 316L stainless steel plate was welded with HFAMF produced by the excitation coil installed on the welding torch. The influence of the HFAMF on the welding process is studied by changing the magnetic frequency from 0 to 2000 Hz. The experimental results show that when the magnetic field frequency reaches 1500 Hz, the arc rotation radius is decreased to the minimum; the arc shape changes from cone to compressed cylinder; and the arc temperature, the arc pressure, and the depth width ratio of the weld beam reached the maximum. Otherwise, the effect of applied HFAMF on the stress of arc and weld pool is discussed, and the mechanism of arc contraction is analyzed.
Rancang Bangun Sistem Rekomendasi Pembukuan Dan Rekonsiliasi Bank Dengan Algoritma Forward Chaining (Studi Kasus: PT Jurnal Consulting Indonesia)
Year: 2018

Rekonsiliasi adalah salah satu proses yang terjadi dalam sistem akuntansi dengan tujuan memastikan tidak ada perbedaan saldo antara rekening bank dan pembukuan perusahaan yang terjadi dalam suatu periode tertentu. Dalam proses rekonsiliasi, seringkali dilakukan secara manual, yaitu dengan membandingkan data hasil print out dari rekening bank dengan apa yang tercatat dalam buku besar perusahaan. Hal ini yang menjadi dasar dalam penelitian ini, yaitu membuat sistem rekomendasi pembukuan dan rekonsiliasi bank untuk membantu pengguna aplikasi Jurnal dalam melakukan proses rekonsiliasi bank. Penelitian ini lebih berfokus untuk membuat sistem rekomendasi kecocokkan data antara rekening koran dengan pembukuan perusahaan berdasarkan aturan pencocokkan yang dapat diatur oleh pengguna agar dapat direkonsiliasi atau merekomendasikan pencatatan ke dalam buku besar apabila terdapat aturan yang cocok dan belum ada data pembukuan. Sistem rekomendasi dibuat dengan algoritma forward chaining untuk menelusuri aturan yang dibuat oleh pengguna hingga menghasilkan rekomendasi kecocokkan apabila terdapat data rekening koran yang cocok dengan pembukuan atau menghasilkan rekomendasi pembukuan apabila memenuhi aturan pencocokkan tetapi belum ada pencatatan ke dalam buku besar perusahaan. Berdasarkan hasil survey dengan tingkat realibilitas kuesioner 0.716575523, dapat disimpulkan bahwa pengguna puas dengan sistem rekomendasi pembukuan dan rekonsiliasi bank dan dapat memenuhi kebutuhan pengguna saat ini.
Intelligent smart parking algorithm
Venue: 2017 International Conference On Smart Technologies For Smart Nation (SmartTechCon)
Year: 2017

In this paper, we will be discussing about the parking system in a city which is embedded with various features like automated, rotary parking and nearest parking slot allotment using IoT and sensor technology. As we know that parking is one of the major problems especially in cities due to lack of required amount of parking area, maintenance facility and lack of proper guidance to park the car. Also there are situations which lead to chaos between people due to lack of proper guidance between them while travelling in the parking area to park the car. In this, we will be providing an algorithm which provides an effective and efficient solution to park the car by using hybrid parking mechanisms to provide more parking efficiency and cost effective with less maintenance and power consumption. Here, we will be using the CMOS sensors for number plate identification, speed sensors for speed detection, ultrasonic sensors for vehicle detection, softwares working OCR, arduino as a microcontroller and Raspberry Pi to interface all the components. The paper focuses on the effective and efficient smart working methods along with guided user safety.
Electric Powertrain: Energy Systems, Power Electronics and Drives for Hybrid, Electric and Fuel Cell Vehicles
Year: 2018

Empowers engineering professionals and students with the knowledge and skills required to engineer electric vehicle powertrain architectures, energy storage systems, power electronics converters and electric drives. The modern electric powertrain is relatively new for the automotive industry, and engineers are challenged with designing affordable, efficient and high performance electric powertrains as the industry undergoes a technological evolution. Co authored by two electric vehicle (EV) engineers with decades of experience designing and putting into production all of the powertrain technologies presented, this book provides readers with the hands on knowledge, skills and expertise they need to rise to that challenge.
RESEARCH ON MOTIVATION,PATH AND SUBJECT OF THE INTEGRATION OF TOURISM INDUSTRY:A CASE STUDY OF FANGTE HIGH TECH THEME PARK MADE BY SHENZHEN HUAQIANG GROUP
Year: 2013

Industry integration is an important trend of the World's industrial and economic development.In the context of fusion in the global industry,tourism is also showing a strong tendency of integration development.Taking Fangte high tech theme park made by Shenzhen Huaqiang Group for an example,the authors research the motivation,path and subject of tourism industry fusion.In the 'Boost Traction' interaction of such forces as technology,market,enterprises and government,tourism industry integration begin to occur and develop.The tourism industrial integration evolution is divided into vertical integration and horizontal integration.The vertical integration is the penetration and extends among different industries to achieve integration.The horizontal integration is the restructuring integration of the elements within the industry,it occurred in different sectors which have close links at the same industry.In the integration evolution of tourism industry,technology and resources is the fusion path.The research of the principle part of tourism industrial integration is still rare.Government or enterprises become a focus of debating among scholars.The paper holds that government is the important promoters;the enterprises are the true principal part of integration in the integration of tourism industry.The enterprises integrate the elements such as technology,resources,capital and markets organically,to create new tourism products,to form a new format.
Bacterial Chitinase System as a Model of Chitin Biodegradation.
Venue: Advances in experimental medicine and biology
Year: 2019

Chitin, a structural polysaccharide of b 1,4 linked N acetyl D glucosamine residues, is the second most abundant natural biopolymer after cellulose. The metabolism of chitin affects the global carbon and nitrogen cycles, which are maintained by marine and soil dwelling bacteria. The degradation products of chitin metabolism serve as important nutrient sources for the chitinolytic bacteria. Chitinolytic bacteria have elaborate enzymatic systems for the degradation of the recalcitrant chitin biopolymer. This chapter introduces chitin degradation and utilization systems of the chitinolytic bacteria. These bacteria secrete many chitin degrading enzymes, including processive chitinases, endo acting non processive chitinases, lytic polysaccharide monooxygenases, and N acetyl hexosaminidases. Bacterial chitinases play a fundamental role in the degradation of chitin. Enzymatic properties, catalytic mechanisms, and three dimensional structures of chitinases have been extensively studied by many scientists. These enzymes can be exploited to produce a range of chitin derived products, e.g. biocontrol agents against many plant pathogenic fungi and insects. We introduce bacterial chitinases in terms of their reaction modes and structural features.
Elective future: The influence factor mining of students' graduation development based on hierarchical attention neural network model with graph
Venue: Applied Intelligence
Year: 2020

The graduation development such as employment and graduate school admission of college students are important tasks. However, mining the factors that can affect the development of graduation remains challenging, because the most important factor "course" is not independent and inequality, which are always ignored by previous researchers. Furthermore, traditional structured methods cannot handle the complex relationships between courses, and attention networks cannot distinguish the weights of compulsory and elective courses with different distributions. Therefore, we present a Graph based Hierarchical Attention Neural Network Model with Elective Course (GHANN EC) for the prediction of graduation development in this study. Specifically, we use graph embedding that captures the unstructured relationships between courses and hierarchical attention that assigns the importance of the courses to excavating course information that represent students' independent interests, and can more accurately understand the relationship between graduation development and academic performance. Experimental results on the real world datasets show that GHANN EC outperforms the existing popular approach.
Effect of an education program, risk assessment checklist and prevention protocol on violence against emergency department nurses: A single center before and after study.
Venue: International emergency nursing
Year: 2020

The purpose of this study was to evaluate the effects of an education program, risk assessment checklist and preventive protocol on violence against emergency department nurses.  The design was a quasi experimental before and after study of a group. A hospital emergency department's nurses participated in a workshop in which they were taught a method of using a risk assessment checklist and preventive protocol. The intervention lasted six weeks. The mean score and type of violence was measured before and after the intervention. The data were analyzed by SPSS.  The mean score of violence before the intervention was 8.4 and after the intervention it was 2.7, which was statistically a significant difference (p 0.0001) In addition, there were significant differences in the mean frequency of verbal abuse (p 0.0001) assessment of workplace security (p 0.006) fear of injury (p 0.02) and type of reaction to violence (p 0.01) before and after the intervention among the nurses.  Using the BVC risk assessment checklist and preventive protocol can reduce the experience of violence and verbal abuse, which is the most common form of violence for emergency department nurses. Using this checklist and preventive protocol when patients arrive in emergency departments is recommended.
Climate change and cultural resilience in late pre Columbian Amazonia
Venue: Nature Ecology Evolution
Year: 2019

The long term response of ancient societies to climate change has been a matter of global debate. Until recently, the lack of integrative studies using archaeological, palaeoecological and palaeoclimatological data prevented an evaluation of the relationship between climate change, distinct subsistence strategies and cultural transformations across the largest rainforest of the world, Amazonia. Here we review the most relevant cultural changes seen in the archaeological record of six different regions within Greater Amazonia during late pre Columbian times. We compare the chronology of those cultural transitions with high resolution regional palaeoclimate proxies, showing that, while some societies faced major reorganization during periods of climate change, others were unaffected and even flourished. We propose that societies with intensive, specialized land use systems were vulnerable to transient climate change. In contrast, land use systems that relied primarily on polyculture agroforestry, resulting in the formation of enriched forests and fertile Amazonian dark earth in the long term, were more resilient to climate change.Across pre Columbian Amazonia, the relationship between cultural transitions and climatic trends is assessed.
Global Navigation Satellite System Software Defined Radio
Year: 2010

The GNSS world is quickly growing. The United States' GPS, the European Union's Galileo, China's Compass, and Russia's GLONASS systems are all developing or modernizing their signals, and there will soon be more navigation satellites in space than ever before. The goal of this research was to develop an initial capability for an AFIT GNSS software receiver. This software receiver is intended to be used for research purposes at the Advanced Navigation Technology (ANT) Center. First a GPS only software receiver was built. It successfully acquired, tracked, and provided reasonable position estimates. Next, the receiver was successfully modified to acquire and track a Compass satellite. This only required relatively small changes in the receiver software. During the tracking process, an interesting finding was discovered concerning the secondary code structure. There are in fact two secondary codes that the transmitter alternates. After AFIT's software receiver was configured properly, the signal was successfully tracked. Finally, the receiver was modified to track one of Galileo's satellites, GIOVE A. After correct parametric changes were made, successful acquisition and tracking of the GIOVE A signal was accomplished. AFIT's GNSS software receiver was shown to provide a high degree of flexibility and accuracy in acquiring and tracking GNSS signals.
A new hybrid Harris hawks Nelder Mead optimization algorithm for solving design and manufacturing problems
Venue: Materials Testing
Year: 2019

In this paper, a novel hybrid optimization algorithm (H HHONM) which combines the Nelder Mead local search algorithm with the Harris hawks optimization algorithm is proposed for solving real world optimization problems. This paper is the first research study in which both the Harris hawks optimization algorithm and the H HHONM are applied for the optimization of process parameters in milling operations. The H HHONM is evaluated using well known benchmark problems such as the three bar truss problem, cantilever beam problem, and welded beam problem. Finally, a milling manufacturing optimization problem is solved for investigating the performance of the H HHONM. Additionally, the salp swarm algorithm is used to solve the milling problem. The results of the H HHONM for design and manufacturing problems solved in this paper are compared with other optimization algorithms presented in the literature such as the ant colony algorithm, genetic algorithm, particle swarm optimization algorithm, simulated annealing algorithm, artificial bee colony algorithm, teaching learning based optimization algorithm, cuckoo search algorithm, multi verse optimization algorithm, Harris hawks optimization optimization algorithm, gravitational search algorithm, ant lion optimizer, moth flame optimization algorithm, symbiotic organisms search algorithm, and mine blast algorithm. The results show that H HHONM is an effective optimization approach for optimizing both design and manufacturing optimization problems.
Perancangan Ulang Tata Letak Ruang Unit Rekam Medis dalam Peningkatan Produktivitas Kerja di Rumah Sakit Paru Surabaya
Year: 2017

ABSTRAK Penyelenggaraan rekam medis yang bermutu dan efektif diperlukan adanya sarana penunjang yang memadai, diantaranya adalah kondisi tata letak unit rekam medis dan ruang penyimpanan berkas rekam medis. Apabila tata letak ruang tidak memenuhi standar tentu akan mengganggu kenyamanan perekam medis. Unit Rekam Medis di Rumah Sakit Paru lantai dua merupakan tempat penyimpanan BRM rawat jalan, rawat inap dan ruang kerja perekam medis urusan pelaporan, filing dan kepala RM. Pengaturan tata letak ruang unit rekam medis belum baik. Penelitian ini bertujuan merancang ulang ruang rekam medis dalam meningkatkan produktivitas kerja perekam medis di Rumah Sakit Paru. Menggunakan metode penelitian deskriptif. Subyek adalah ruang Unit Rekam Medis lantai dua Rumah Sakit Paru. Variabel penelitian adalah Unit rekam medis, urusan filing, urusan pelaporan, urusan kepala rekam medis, perekam medis, tata letak ruang unit rekam medis, tata letak ruang urusan filing, tata letak ruang urusan pelaporan, tata letak ruang urusan kepala rekam medis dan produktivitas kerja. Hasil penelitian adalah letak meja kepala rekam medis rancangan baru ruang unit rekam medis paling belakang dari meja filing, meja scanner dan meja pelaporan. Hasil pernyataan sangat setuju oleh perekam medis terhadap rancangan ulang ruang unit rekam medis dapat meningkatkan produktivitas kerja perekam medis di Rumah Sakit Paru.
Etre ou ne pas etre une borreliose de Lyme Une approche pluridisciplinaire pour un diagnostic plus juste et un parcours de soin personnalise
Venue: Medecine et Maladies Infectieuses
Year: 2019

De nombreux patients presentant une suspicion de borreliose de Lyme (BL) experimentent un parcours de soin difficile. Nous avons mis en place un Centre pluridisciplinaire de prise en charge des maladies vectorielles a tique, regroupant infectiologues, rhumatologues, internistes, neurologues, pediatres, dermatologues, microbiologistes, psychiatres, algologues, medecins de readaptation. Une ligne telephonique dediee a ete creee pour les medecins traitants (MT) L'objectif de ce travail est de presenter l'activite de notre centre (janvier decembre 2018) Materiels et methodes Nous avons retrospectivement analyse les caracteristiques des patients adultes ayant consulte, adresses par leur MT, et leur parcours de soins au sein du centre. Tous etaient presentes en reunion de concertation pluridisciplinaire mensuelle. Les patients ayant des signes cliniques en lien avec une BL etaient definis selon l'ESGBOR (i)BL confirmee (ii)BL possible (piqure de tique ou antecedent d'erytheme migrant, signes cliniques tres evocateurs, amelioration clinique apres 21 28j d'antibiotiques) (iii)PTLDS (post treatment Lyme disease Syndrome) (asthenie/polyalgie/plaintes cognitives persistantes apres traitement bien conduit) (iv) sequelles de BL (signes cliniques objectifs persistants apres traitement bien conduit) (v) surveillance post piqure de tique (vi) guerison. Seules les BL prouvees et possibles ont recu une antibiotherapie (recommandations HAS 2018) Resultats Nous avons propose 3 orientations aux 180 patients ayant consulte (consultations externes (n 97 53,9 hospitalisation (n 49 27,2 et/ou hospitalisation de jour (n 58 32,2 et realise 370 consultations de suivi (toutes specialites) Un total de 69 patients (38,3 presentaient des signes cliniques en lien avec une BL BL confirmee (n 28 15,6 BL possible (n 12 ;6,7 PTLDS (n 11 6,1 sequelles (n 5 2,8 surveillance post piqure de tique (n 5 2,8 guerison (n 8 4,4 Des diagnostics associes ou differentiels ont ete trouves chez 146/180 (81 infectieux (n 19 10,6 rhumatologique/auto immun (n 45 25 carentiel/metabolique (n 25 13,9 bodily distress syndrome (n 19 10,6 neurologique (n 19 10,6 psychiatrique (n 17 9,4 effets secondaires des antibiotherapies prolongees (n 15 8,3 autres (n 12 ;6,7 absence de diagnostic (n 25 ;13,9 perdus de vue (n 9 5 Un plan personnalise de soins a ete propose a chaque patient dans la filiere adaptee, meme si absence de diagnostic (algologie, readaptation etc. Les questionnaires de satisfaction (n 146) montraient 137 patients (93,8 satisfaits.  Ces resultats concordent avec les experiences publiees de centres pluridisciplinaires. Les liens etablis avec les MT facilitent le diagnostic de BL et le parcours de soins. Le nombre de diagnostics differentiels ou associes confirment la complexite du diagnostic de BL sans omettre d'autres diagnostics. Une prise en charge pluridisciplinaire permet un diagnostic plus precis et une prise en charge personnalisee des patients.