nils-herrmann/clean_scirepeval huggingface dataset:
Performance of new automated transthoracic three dimensional echocardiographic software for left ventricular volumes and function assessment in routine clinical practice: Comparison with 3 Tesla cardiac magnetic resonance.
Venue: Archives of cardiovascular diseases
Year: 2017

Three dimensional (3D) transthoracic echocardiography (TTE) is superior to two dimensional Simpson's method for assessment of left ventricular (LV) volumes and LV ejection fraction (LVEF) Nevertheless, 3D TTE is not incorporated into everyday practice, as current LV chamber quantification software products are time consuming.  To evaluate the feasibility, accuracy and reproducibility of new fully automated fast 3D TTE software (HeartModelA.I. Philips Healthcare, Andover, MA, USA) for quantification of LV volumes and LVEF in routine practice; to compare the 3D LV volumes and LVEF obtained with a cardiac magnetic resonance (CMR) reference; and to optimize automated default border settings with CMR as reference.  Sixty three consecutive patients, who had comprehensive 3D TTE and CMR examinations within 24hours, were eligible for inclusion. Nine patients (14% were excluded because of insufficient echogenicity in the 3D TTE. Thus, 54 patients (40 men; mean age 63+ 13 years) were prospectively included into the study.  The inter and intraobserver reproducibilities of 3D TTE were excellent (coefficient of variation<10% for end diastolic volume (EDV) end systolic volume (ESV) and LVEF. Despite a slight underestimation of EDV using 3D TTE compared with CMR (bias= 22+ 34mL; P<0.0001) a significant correlation was found between the two measurements (r=0.93; P=0.0001) Enlarging default border detection settings leads to frequent volume overestimation in the general population, but improved agreement with CMR in patients with LVEF<=50% Correlations between 3D TTE and CMR for ESV and LVEF were excellent (r=0.93 and r=0.91, respectively; P<0.0001) CONCLUSION 3D TTE using new generation fully automated software is a feasible, fast, reproducible and accurate imaging modality for LV volumetric quantification in routine practice. Optimization of border detection settings may increase agreement with CMR for EDV assessment in dilated ventricles.
Mechanics Modeling of Tendon Driven Continuum Manipulators
Venue: IEEE Transactions on Robotics
Year: 2008

Continuum robotic manipulators articulate due to their inherent compliance. Tendon actuation leads to compression of the manipulator, extension of the actuators, and is limited by the practical constraint that tendons cannot support compression. In light of these observations, we present a new linear model for transforming desired beam configuration to tendon displacements and vice versa. We begin from first principles in solid mechanics by analyzing the effects of geometrically nonlinear tendon loads. These loads act both distally at the termination point and proximally along the conduit contact interface. The resulting model simplifies to a linear system including only the bending and axial modes of the manipulator as well as the actuator compliance. The model is then manipulated to form a concise mapping from beam configuration space parameters to n redundant tendon displacements via the internal loads and strains experienced by the system. We demonstrate the utility of this model by implementing an optimal feasible controller. The controller regulates axial strain to a constant value while guaranteeing positive tendon forces and minimizing their magnitudes over a range of articulations. The mechanics based model from this study provides insight as well as performance gains for this increasingly ubiquitous class of manipulators.
TDV Cache: Organizing Off Chip DRAM Cache of NVMM from a Fusion Perspective
Venue: 2017 IEEE International Conference on Computer Design (ICCD)
Year: 2017

Emerging Non Volatile Memory (NVM) provides both larger memory capacity and higher energy efficiency, but has much longer access latency than traditional DRAM, thus DRAM can be used as an efficient cache to hide the long latency of Non Volatile Main Memory (NVMM) system. Transparent Off chip DRAM cache (TOD cache) is a new DRAM cache structure where off chip DRAM module is used as L4 cache and managed by hardware. The capacity and latency ratio of TOD cache over NVM are both quite different from those of traditional on chip SRAM or die stacked DRAM cache over off chip DRAM memory. All the factors including hit latency, miss latency and hit rate need to be re considered for TOD cache design. In this study, we first point out that three types of traditional cache schemes cannot be used directly for TOD cache, since set associative cache suffers from extra tag lookup latency, direct mapped cache has low hit rate and tag cache is too small to efficiently hold the working sets of tags for DRAM cache. Based on these observations, we propose a novel cache scheme, TDV, that fuses these three different types of cache together to take their advantages. In TDV, a direct mapped cache is used as the first level cache to achieve short access latency, a set associative victim cache is taken as the second level cache to obtain extra high hit rate, and a SRAM tag cache only serves for the victim cache rather than the whole DRAM cache and thus improves the hit rate of tag cache significantly. The simulation results show that, TDV cache has a performance improvement of 6.3% and 8.3% on average than state of the art direct mapped (Alloy cache) and set associative cache (ATCache) with same DRAM and SRAM capacity.
SinGAN GIF: Learning a Generative Video Model from a Single GIF
Venue: 2021 IEEE Winter Conference on Applications of Computer Vision (WACV)
Year: 2021

We propose SinGAN GIF, an extension of the image based SinGAN  to GIFs or short video snippets. Our method learns the distribution of both the image patches in the GIF as well as their motion patterns. We do so by using a pyramid of 3D and 2D convolutional networks to model temporal information while reducing model parameters and training time, along with an image and a video discriminator. SinGAN GIF can generate similar looking video samples for natural scenes at different spatial resolutions or temporal frame rates, and can be extended to other video applications like video editing, super resolution, and motion transfer. The project page, with supplementary video results, is: https:/rajat95.github.io/singan gif/
The impact of workplace bullying on hotel employees' well being
Venue: International Journal of Contemporary Hospitality Management
Year: 2019

PurposeThe purpose of this study was to investigate the moderating effects of organizational justice and workplace friendship on the relationship between workplace bullying and hotel employees' well being.approachThe research sample included 310 entry level employees of international tourism hotels in Taiwan. This study adopted hierarchical regression for data analysis. study found that workplace bullying negatively impacted on hotel employees' well being. Organizational justice and workplace friendship had significantly positive effects on hotel employees' well being. Compared with workplace friendship, organizational justice had a significant moderating effect on the relationship between workplace bullying and hotel employees' well being. the research fields of hospitality, past studies failed to use organizational justice and workplace friendship to moderate the relationship between workplace bullying and hotel employees' well being. This study confirmed that organizational justice could effectively buffer the negative effect of workplace bullying on hotel employees' well being.
S2A: Wasserstein GAN with Spatio Spectral Laplacian Attention for Multi Spectral Band Synthesis
Venue: 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)
Year: 2020

Intersection of adversarial learning and satellite image processing is an emerging field in remote sensing. In this study, we intend to address synthesis of high resolution multi spectral satellite imagery using adversarial learning. Guided by the discovery of attention mechanism, we regulate the process of band synthesis through spatio spectral Laplacian attention. Further, we use Wasserstein GAN with gradient penalty norm to improve training and stability of adversarial learning. In this regard, we introduce a new cost function for the discriminator based on spatial attention and domain adaptation loss. We critically analyze the qualitative and quantitative results compared with state of the art methods using widely adopted evaluation metrics. Our experiments on datasets of three different sensors, namely LISS 3, LISS 4, and WorldView 2 show that attention learning performs favorably against state of the art methods. Using the proposed method we provide an additional data product in consistent with existing high resolution bands. Furthermore, we synthesize over 4000 high resolution scenes covering various terrains to analyze scientific fidelity. At the end, we demonstrate plausible large scale real world applications of the synthesized band.
Small molecule ISRIB suppresses the integrated stress response within a defined window of activation
Venue: Proceedings of the National Academy of Sciences
Year: 2019

The integrated stress response (ISR) protects cells from a variety of harmful stressors by temporarily halting protein synthesis. However, chronic ISR activation has pathological consequences and is linked to several neurological disorders. Pharmacological inhibition of chronic ISR activity emerges as a powerful strategy to treat ISR mediated neurodegeneration but is typically linked to adverse effects due to the ISR's importance for normal cellular function. Paradoxically, the small molecule ISR inhibitor ISRIB has promising therapeutic potential in vivo without overt side effects. We demonstrate here that ISRIB inhibits low level ISR activity, but does not affect strong ISR signaling. We thereby provide a plausible mechanism of how ISRIB counteracts toxic chronic ISR activity, without disturbing the cytoprotective effects of a strong acute ISR. Activation of the integrated stress response (ISR) by a variety of stresses triggers phosphorylation of the a subunit of translation initiation factor eIF2. P eIF2a inhibits eIF2B, the guanine nucleotide exchange factor that recycles inactive eIF2*GDP to active eIF2*GTP. eIF2 phosphorylation thereby represses translation. Persistent activation of the ISR has been linked to the development of several neurological disorders, and modulation of the ISR promises new therapeutic strategies. Recently, a small molecule ISR inhibitor (ISRIB) was identified that rescues translation in the presence of P eIF2a by facilitating the assembly of more active eIF2B. ISRIB enhances cognitive memory processes and has therapeutic effects in brain injured mice without displaying overt side effects. While using ISRIB to investigate the ISR in picornavirus infected cells, we observed that ISRIB rescued translation early in infection when P eIF2a levels were low, but not late in infection when P eIF2a levels were high. By treating cells with varying concentrations of poly(I:C) or arsenite to induce the ISR, we provide additional proof that ISRIB is unable to inhibit the ISR when intracellular P eIF2a concentrations exceed a critical threshold level. Together, our data demonstrate that the effects of pharmacological activation of eIF2B are tuned by P eIF2a concentration. Thus, ISRIB can mitigate undesirable outcomes of low level ISR activation that may manifest neurological disease but leaves the cytoprotective effects of acute ISR activation intact. The insensitivity of cells to ISRIB during acute ISR may explain why ISRIB does not cause overt toxic side effects in vivo.
Analogy preserving Semantic Embedding for Visual Object Categorization
Venue: ICML
Year: 2013

In multi class categorization tasks, knowledge about the classes' semantic relationships can provide valuable information beyond the class labels themselves. However, existing techniques focus on preserving the semantic distances between classes (e.g. according to a given object taxonomy for visual recognition) limiting the influence to pairwise structures. We propose to model analogies that reflect the relationships between multiple pairs of classes simultaneously, in the form "p is to q, as r is to s" We translate semantic analogies into higher order geometric constraints called analogical parallelograms, and use them in a novel convex regularizer for a discriminatively learned label embedding. Furthermore, we show how to discover analogies from attribute based class descriptions, and how to prioritize those likely to reduce inter class confusion. Evaluating our Analogy preserving Semantic Embedding (ASE) on two visual recognition datasets, we demonstrate clear improvements over existing approaches, both in terms of recognition accuracy and analogy completion.
Derivations of Exact Lattice Boltzmann Evolution Equation
Year: 2020

A comparative analysis on the schemes for exact lattice Boltzmann (LB) evolution equation is presented in this paper. It includes two classical exact LB schemes, i.e. Bosch Karlin (BK) scheme and He Luo (HL) scheme, and the present Taylor expansion (TE) scheme. TE scheme originates from the extension of BK scheme. The mathematical mechanism and the equilibrium distribution evolution behind these exact schemes have been detailedly addressed. After that, an analysis is carried out to discuss the cause of the LB equation difference among the schemes, which offers an insight of the exactness in these schemes and brings up their continuity precondition. At last, the schemes are systematically addressed for their pros and cons in the further development of LB equations.
Matrix Profile V: A Generic Technique to Incorporate Domain Knowledge into Motif Discovery
Venue: KDD
Year: 2017

Time series motif discovery has emerged as perhaps the most used primitive for time series data mining, and has seen applications to domains as diverse as robotics, medicine and climatology. There has been recent significant progress on the scalability of motif discovery. However, we believe that the current definitions of motif discovery are limited, and can create a mismatch between the user's intent/expectations, and the motif discovery search outcomes. In this work, we explain the reasons behind these issues, and introduce a novel and general framework to address them. Our ideas can be used with current state of the art algorithms with virtually no time or space overhead, and are fast enough to allow real time interaction and hypotheses testing on massive datasets. We demonstrate the utility of our ideas on domains as diverse as seismology and epileptic seizure monitoring.
From cells to embryos to rooted plantlets in a mist bioreactor
Venue: Plant Cell, Tissue and Organ Culture (PCTOC)
Year: 2013

A mist bioreactor using a disposable bag as culture chamber was used to propagate carrot embryogenic cells into rooted plantlets. The best operating configuration was akin to a vertical hanging garden using 50 90 mm nylon mesh for explant attachment. Cells spray inoculated into the reactor were 51.2 viable. Misting cycle and aeration conditions were studied and showed that under the same hourly volumetric nutrient feed and 0 VVM, embryo development in the reactor was best using a 0.3 min on/2.7 min off misting cycle, yielding about 23 post heart stage embryos. Compared to 0 VVM, 3 CO2 enrichment improved embryo development in reactor culture. Spray inoculated cells also attached to several vertically hung poly l lysine coated strips and then developed in situ into embryos. Cell attachment was significantly improved when they were suspended in salt free sucrose solution during spray inoculation. Almost 90 of the originally attached cells remained on the nylon mesh 24 h later after spraying with B5 medium in the mist reactor. Strip grown embryos had the same post heart stage ratio but shorter overall length compared to those developed on a horizontal platform. Young plantlets developed uniformly up and down the hanging strips and did not detach after 3 weeks of culture suggesting this technology may prove useful for improving micropropagation.
Pelatihan Etude untuk Snare Drum pada Section Battery Percussion: Studi Kasus Marching Band Saraswati Institut Seni Indonesia Yogyakarta
Year: 2017

Marching Band merupakan sekelompok barisan orang yang memainkan beberapa lagu menggunakan sejumlah kombinasi alat musik. Snare drum merupakan salah satu instrumen dari sebuah kelompok ensembel battery percussion. Snare drum memiliki player yang lebih banyak dibanding player battery percussion lainnya. Dengan demikian tentunya memiliki tingkat kesulitan yang lebih kompleks dibanding players lainnya. Metode penelitian yang dipakai untuk pengamatan penelitian ini adalah metode penelitian kualitatif. Tahap pembentukan pemain marching band (skill, visual, dan sebagainya) ada tiga tahap yaitu technique, reading, dan musicianship. Dalam tiga tahap tersebut, penelitian ini berada pada tahap technique atau hal yang paling dasar. Fokus yang diteliti adalah cara atau model pelatihan etude snare drum. Selain cara/model melatih, juga diteliti mengenai kendala kendala dan cara mengatasi kendala kendala dalam melatih 15 etude snare drum. Dalam ensembel batery percussion khususnya pemain snare drum memiliki sikap sikap dasar ketika membawa alat. Etude dalam Marching Band Saraswati Institut Seni Indonesia Yogyakarta (MBSI) adalah suatu etude untuk mempelajari suatu teknik tertentu. Dengan 15 macam etude instrument snare drum memiliki maksud dan tujuan masing masing.  Snare drum, etude, model pelatihan, Marching Band Saraswati, Institut Seni Indonesia Yogyakarta.
Role of astroglia in Down's syndrome revealed by patient derived human induced pluripotent stem cells
Venue: Nature Communications
Year: 2014

Down's syndrome (DS) caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS patients to identify a role for astrocytes in DS pathogenesis. DS astroglia exhibit higher levels of reactive oxygen species and lower levels of synaptogenic molecules. Astrocyte conditioned medium collected from DS astroglia causes toxicity to neurons, and fails to promote neuronal ion channel maturation and synapse formation. Transplantation studies show that DS astroglia do not promote neurogenesis of endogenous neural stem cells in vivo. We also observed abnormal gene expression profiles from DS astroglia. Finally, we show that the FDA approved antibiotic drug, minocycline, partially corrects the pathological phenotypes of DS astroglia by specifically modulating the expression of S100B, GFAP, inducible nitric oxide synthase, and thrombospondins 1 and 2 in DS astroglia. Our studies shed light on the pathogenesis and possible treatment of DS by targeting astrocytes with a clinically available drug. Down's syndrome is characterized by intellectual disability and other neuropathological symptoms. Here, the authors show that astroglia derived from induced pluripotent stem cells from Down's syndrome patients impair the development of neurons, and that this can be attenuated with the drug minocycline.
Perbandingan Hasil Pemeriksaan Glukosa Darah Dengan Menggunakan Serum Dan Plasma Natrium Fluorida (NaF) Di Laboratorium Klinik Medika Jayapura
Year: 2020

The purpose of this research was to compare the results of examination of blood glucose levels using serum and plasma Sodium Fluoride (NaF) The population used in this study were all patients who came to check blood glucose while at the Medika Clinic Laboratory. The number of samples in this research was 67 (total population) The method used in examination of blood glucose is the enzymatic method of Glucose Oxidase (GOD PAP) This research was conducted for 1 month, from April 1 to April 30, 2017. To compare the values between serum and plasma sodium fluoride (NaF) specimens, it was analyzed statistically using the Social Science Stastistial Program (SPSS) for windows version 21 with the test method Mann Whitney and obtained a mean of 154.49 mg/dl in serum specimens and 145.36 mg/dl in plasma specimens of sodium fluoride (NaF) The results of statistical tests of blood glucose levels with serum and plasma NaF specimens showed no significant difference and obtained a significance value of 0.196 which means a probability >0.05. The conclusion of this research is that there is no significant difference between the examination of blood glucose using serum specimens and plasma Sodium Fluoride (NaF) Keywords Blood Glucose Serum, Sodium fluorida (NaF)
Building on Principles: The Case for Comprehensive, Proportionate Governance of Data Access
Venue: Medical Data Privacy Handbook
Year: 2015

The amount of data in the world is growing rapidly. Researchers and others see the value of these data to answer compelling questions, and sometimes this involves linking different data sets together. Good and long standing processes for governing access to data exist, but these will be challenged with the amount and breadth of data researchers wish to use. In particular, it is increasingly clear that in this new world of data, data access governance cannot continue to rely on traditional approaches of de identification, anonymization and individual consent. An alternative to these risk minimization approaches is proportionate governance, a process that assesses potential risks and mitigations to those risks, including the potential public interest that is served by enabling research. We propose a flexible and adaptable proportionate governance framework that builds on existing models. Local adoption of this framework will require engagement with stakeholder to create consensus around principles, and implies broad commitment to the notion of a more open research culture.
The compositions of low molecular weight therapeutics
Year: 2011

1. A composition comprising a therapeutic agent and a low molecular weight alkyl (N, N disubstituted amino) . A composition according to claim 1, characterized in that the small molecule therapeutic agent is selected from the group consisting of a taxane and a compound belonging according biopharmaceutical classification system (BCS) to at least one of the classes 2, 3, or 4.3. A composition according to claim 2, wherein the taxane is a member of the group consisting of paclitaxel, docetaxel and their tesetaksela smesey.4. A composition according to claim 2, characterized in that said compound is a Class 2 BKS.5. A composition according to claim 4, characterized in that said compound is selected from the group consisting of lansoprazole, haloperidol, sulfasalazine and glibenklamida.6. A composition according to claim 2, characterized in that said compound is a Class 3 BKS.7. A composition according to claim 6, characterized in that said compound is selected from the group consisting of atenolol, glucosamine or salts thereof and . A composition according to claim 2, characterized in that said compound is a Class 4 BKS.9. A composition according to claim 8, wherein the compound is selected from the group consisting of furosemide, and chlorothiazide gidrohlortiazida.10. A composition according to claim 1, further comprising a physiologically acceptable nositel.11. A composition according to claim 1, characterized in that the alkyl (N, N disubstituted amino) acetate is dodecyl 2 (N, N dimethylamino) propionat.12. A composition according to claim 1, characterized in that the alkyl (N, N disubstituted amino) acetate hydrochloride is dodecyl 2 (N, N dimethylamino) propionata.13. A composition according to claim 1, characterized in that the low molecular weight therapeutic agents