nils-herrmann/clean_scirepeval huggingface dataset:
Rapidly intensified, long duration North Indian Ocean tropical cyclones: Mesoscale downscaling and validation
Year: 2021

High resolution (6 km x 6 km) reanalyses (HRR) have been generated using the Advanced Research Weather Research and Forecasting model (WRF ARW) and three dimensional variational Ensemble Kalman Filter (3DEnKF) The six hourly cyclic downscaling methodology has been used to develop HRR for simulating the life cycle of three rapidly intensified long life tropical cyclones (TCs) viz. Fani, Ockhi, and Luban over the North Indian Ocean (NIO) The available surface and upper air observations, radiance data, and scatterometer/radiometer wind data have been assimilated. The simulated maximum surface wind (intensity) minimum sea level pressure (MSLP) and cyclone tracks have been compared to the International Best Track Archive For Climate Stewardship (IBTrACS) dataset. During the maximum intensity stage, the model successfully simulated the maximum surface wind variation and drop of MSLP. The surface winds validated using the Research Moored Array for African Asian Australian Monsoon Analysis and Prediction (RAMA) buoys observations showed a better correlation at the cyclonic stage and severe cyclonic stage compared to the very severe cyclonic stage. Comparing wind distribution at 850 hPa to the 5th Generation European Centre for Medium Range Weather Forecasts Reanalysis (ERA5) showed that the analysis successfully captured more intense TC stages. The significant wind structure features in the surface, lower, middle, and upper tropospheric observed by Scatsat 1 and INSAT3D/3DR satellites have been simulated by analysis. The rapid intensifications (RI) of considered TCs were successfully simulated in the analysis. The simulated and the Global Precipitation Measurement (GPM) accumulated rainfall distribution was found to be collocated, especially over heavy rainfall regions.
Smartphone Apps for Agri information dissemination during Covid19 lockdown
Year: 2020

The use of mobile technologies as a tool of intervention in agriculture is becoming increasingly popular. Smartphone penetration enhances the multi dimensional positive impact on sustainable poverty reduction and identifies accessibility as the main challenge in harnessing the full potential in agricultural space. Different elements affected the agriculture development; however, the most essential bottlenecks are lack of instant information and drudgery involved in farming practices. To conquer these issues, agriculture should be made more alluring and done smartly. Corona virus (COVID 19) Lockdown harms Agriculture Sector in India, as farmers are unable to get the latest information regarding various agricultural issues, market Status other relevant information related to the agriculture allied sector, smartphone apps act an important tool for agricultural information dissemination during this period. There are varieties of mobile applications, utilized over the globe for different segments, including farming, but in our country, the usage is still is limited. In India, there are enormous opportunities for utilizing smartphones as a part of agribusiness improvement. Its utilization is vital for quick growth and easy access to information to Indian agriculturists, farmers, and growers.
Metodologia para la accesibilidad en el espacio fisico de los puestos de trabajo. Una perspectiva desde el diseno y la ergonomia participativa
Year: 2013

En Colombia, las empresas tienen la posibilidad, el deber legal y los espacios dentro de los procesos productivos para vincular personas con discapacidad; sin embargo, dicho acceso al entorno laboral es muy bajo, dado que cuando se quiere realizar dicha incorporacion, no es claro como ejecutar el diseno y la adaptacion de los entornos fisicos para favorecer la accesibilidad de este tipo de poblacion. Con base en los conceptos de ergonomia, ergonomia participativa y accesibilidad, se analizaron distintos proyectos de diseno realizados en la Industria Militar (Indumil) fruto de esto, se propone la metodologia F. A. P. (Focalizar, Apreciar, Proponer) fundamentada en la interaccion entre la persona que dirige la intervencion y el personal directivo, operativo e interdisciplinar, quienes intervienen en las diferentes fases del desarrollo de la metodologia propuesta. No obstante, esta no seria adecuada sin la orientacion, disposicion y confianza generada por la fundamentacion, el flujo de informacion y la inmersion que la persona encargada del proyecto tuvo que cumplir y desarrollar.
The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin
Venue: Cell
Year: 2017

Centrosomes are non membrane bound compartments that nucleate microtubule arrays. They consist of nanometer scale centrioles surrounded by a micron scale, dynamic assembly of protein called the pericentriolar material (PCM) To study how PCM forms a spherical compartment that nucleates microtubules, we reconstituted PCM dependent microtubule nucleation in vitro using recombinant C. elegans proteins. We found that macromolecular crowding drives assembly of the key PCM scaffold protein SPD 5 into spherical condensates that morphologically and dynamically resemble in vivo PCM. These SPD 5 condensates recruited the microtubule polymerase ZYG 9 (XMAP215 homolog) and the microtubule stabilizing protein TPXL 1 (TPX2 homolog) Together, these three proteins concentrated tubulin ~4 fold over background, which was sufficient to reconstitute nucleation of microtubule asters in vitro. Our results suggest that in vivo PCM is a selective phase that organizes microtubule arrays through localized concentration of tubulin by microtubule effector proteins.
Synergistic effect of tri n butyl phosphate (TBP) or tri n octyl phosphine oxide (TOPO) with didodecylphosphoric acid (HDDPA) on extraction of uranium(VI) and thorium(IV) ions
Venue: Journal of Radioanalytical and Nuclear Chemistry
Year: 2017

Importance of removal of radioactive elements from wastewater was the motivation behind this work. Synergistic solvent extraction of U(VI) and Th(IV) ions from perchlorate solution using didodecylphosphoric acid (HDDPA) incorporated with tri n butyl phosphate (TBP) or tri n octylphosphine oxide (TOPO) as a synergists have been studied for the first time. The effects of HDDPA concentration, synergist's concentration, pH values and temperature on the extraction process have been studied. The thermodynamic parameters of the extraction process for these ions were calculated. It was found that the synergistic contribution of TOPO is higher than TBP in the extraction of Th(IV) and U(VI)
The new stability criteria of discrete time switched systems with an improved mode dependent average dwell time approach
Venue: Appl. Math. Comput.
Year: 2020

This paper investigates the stability analysis of discrete time switched systems with two subsystems (DSTSs) By the modified mode dependent average dwell time (MDADT) approach, new stability criteria of DSTSs are obtained in both nonlinear and linear contexts, which are less conservative and more applicable in practice than those existing results. The design of stabilizing controller for linear DSTSs also is addressed by using LMIs. At last, three numerical examples with some comparisons to the existing results are involved to illustrate the superiority of the results in the paper.
Vitamin C is a source of oxoaldehyde and glycative stress in age related cataract and neurodegenerative diseases
Venue: Aging cell
Year: 2020

Oxoaldehyde stress has recently emerged as a major source of tissue damage in aging and age related diseases. The prevailing mechanism involves methylglyoxal production during glycolysis and modification of arginine residues through the formation of methylglyoxal hydroimidazolones (MG H1) We now tested the hypothesis that oxidation of vitamin C (ascorbic acid or ASA) contributes to this damage when the homeostatic redox balance is disrupted especially in ASA rich tissues such as the eye lens and brain. MG H1 measured by liquid chromatography mass spectrometry is several fold increased in the lens and brain from transgenic mice expressing human vitamin C transporter 2 (hSVCT2) Similarly, MG H1 levels are increased two to fourfold in hippocampus extracts from individuals with Alzheimer's disease (AD) and significantly higher levels are present in sarkosyl insoluble tissue fractions from AD brain proteins than in the soluble fractions. Moreover, immunostaining with antibodies against methylglyoxal hydroimidazolones reveals similar increase in substantia nigra neurons from individuals with Parkinson's disease. Results from an in vitro incubation experiment suggest that accumulated catalytic metal ions in the hippocampus during aging could readily accelerate ASA oxidation and such acceleration was significantly enhanced in AD. Modeling studies and intraventricular injection of 13C labeled ASA revealed that ASA backbone carbons 4 6 are incorporated into MG H1 both in vitro and in vivo, likely via a glyceraldehyde precursor. We propose that drugs that prevent oxoaldehyde stress or excessive ASA oxidation may protect against age related cataract and neurodegenerative diseases.
Assessment of the DoD Establishment of the Office of Security Cooperation Iraq
Year: 2012

Our purpose was to determine whether DoD did the following: (1) met requirements to effectively execute the plan for transitioning authority, personnel, and equipment from DoD to Chief of Mission Baghdad; and (2) provided the required support to meet initial operating capability to ensure that the Office of Security Cooperation Iraq (OSC I) at full operating capability would be sufficient to accomplish the mission of supporting Iraqi Security Forces capability development. The establishment of the OSC I was on track and on schedule to meet its full operating capability target date of October 1, 2011, and to operate independently as an element of U.S. Mission to Iraq by January 1, 2012. However, we identified key areas that required management attention. We determined that U.S. Forces Iraq Deputy Commanding General for Advising and Training was managing crucial security cooperation activities with incomplete theater and country level plans and without required planning capability, had not clearly communicated information about the OSC I enduring role regarding security cooperation programs with key Ministry of Defense and Ministry of Interior officials, had not fully engaged and shared essential transition details with key personnel at prospective outlying OSC I sites, and had not established detailed internal standard operating procedures (SOPs) for the OSC I essential to adequately manage its major functions within the framework of the U.S. Mission to Iraq. We recommend that the Commander, U.S. Central Command, promptly issue completed Iraq Country Plan details and that the Chief, OSC I, improve information flow to site personnel, communicate sufficient details about the OSC I role and its operating processes with key Iraqi defense and interior ministry officials, and develop SOPs for OSC I administrative and operational processes and procedures that include interagency operations within the overall framework of U.S. Mission to Iraq authority and responsibility.
A Makerspace Foot Pedal and Shoe Add On for Seated Virtual Reality Locomotion
Venue: 2019 IEEE 9th International Conference on Consumer Electronics (ICCE Berlin)
Year: 2019

Virtual reality advances are constantly pushing the envelope of what is possible in the realm of human computer interaction to provide more engaging and immersive experiences. Recent trends in consumer virtual reality are seeing the development of stand alone headsets providing portable wireless experiences. However, one aspect of VR that is still in need of improvement is user friendly, immersive, intuitive, and effective locomotion. Currently, commodity locomotion is achieved through teleportation, gamepad based, or room scale locomotion, unlike high end systems featuring omnidirectional treadmills that require higher investment and specialized infrastructure. Proper virtual reality locomotion can increase immersion, presence, and allow effective interactions that can positively impact applications in health care, education, training, and safety. In this paper, we present a preliminary usability study on seated virtual reality locomotion employing consumer level devices, teleportation, and two custom made devices employing 3D printing and open electronics as an alternative for walking in VR.
Double/Debiased Machine Learning for Dynamic Treatment Effects
Venue: ArXiv
Year: 2020

We consider the estimation of treatment effects in settings when multiple treatments are assigned over time and treatments can have a causal effect on future outcomes. We formulate the problem as a linear state space Markov process with a high dimensional state and propose an extension of the double/debiased machine learning framework to estimate the dynamic effects of treatments. Our method allows the use of arbitrary machine learning methods to control for the high dimensional state, subject to a mean square error guarantee, while still allowing parametric estimation and construction of confidence intervals for the dynamic treatment effect parameters of interest. Our method is based on a sequential regression peeling process, which we show can be equivalently interpreted as a Neyman orthogonal moment estimator. This allows us to show root n asymptotic normality of the estimated causal effects.
KORELASI PERILAKU KADARZI TERHADAP STATUS GIZI BALITA DI PUSKESMAS SIMPANG TIMBANGAN INDRALAYA TAHUN 2014
Year: 2015

Data cakupan program Puskesmas Simpang Timbangan menunjukkan angka yang rendahpada program kadarzi menimbang berat badan balita secara teratur (66,92% ASI eksklusif (26,83%,pemberian kapsul vitamin A pada balita usia 12 59 bulan (51,52% Berdasarkan BB/U ditemukan 2 (dua)balita gizi kurang dan 1 (satu) balita gizi buruk. Oleh karena itu, penelitian ini bertujuan untuk mengetahuihubungan perilaku keluarga sadar gizi (kadarzi) terhadap status gizi balita usia 6 23 bulan di PuskesmasSimpang Timbangan tahun 2014.Metode: Penelitian ini merupakan studi analitik dengan pendekatan cross sectional. Sampel dalam penelitianini adalah balita usia 6 23 bulan yang berada di wilayah kerja Puskesmas Simpang Timbangan tahun 2014yaitu sebanyak 73 balita. Responden dari penelitian ini adalah ibu balita. Alat pengumpulan data yangdigunakan adalah berupa kuesioner melalui wawancara, baby scale dan meteran melalui pengukuranantropometri balita secara langsung.Hasil Penelitian: Tidak ada hubungan yang bermakna antara perilaku kadarzi dengan status gizi balita usia6 23 bulan berdasarkan indikator BB/U (p 1,000) PB/U (p= 0,466) BB/PB (p= 1,000) dan IMT/U (p=1,000).Kesimpulan: Tidak ada hubungan perilaku keluarga sadar gizi (kadarzi) terhadap status gizi balita usia 6 23bulan. Disarankan kepada Dinas Kesehatan dan Pemerintah Daerah Ogan Ilir perlu meningkatkan pembinaanatau pelatihan untuk petugas puskesmas terutama bidan kelurahan dan petugas gizi puskesmas untukmeningkatkan promosi mengenai keluarga sadar gizi. Keluarga Sadar Gizi (Kadarzi) status gizi balita
TIGIT: a novel immunotherapy target moving from bench to bedside
Venue: Cancer Immunology, Immunotherapy
Year: 2018

Treatment strategies for patients with advanced solid tumors have traditionally been based on three different paradigms: surgery, cytotoxics (chemotherapy or radiation therapy) and targeted therapies. Immunotherapy has emerged as a novel treatment paradigm in our armamentarium. Unfortunately, most patients still do not benefit from immunotherapy. These patients often have "cold tumors" characterized by a paucity of effector T cells in the tumor microenvironment, low mutational load, low neoantigen burden and often an immunosuppressive tumor microenvironment. TIGIT is an immunoreceptor inhibitory checkpoint that has been implicated in tumor immunosurveillance. Expression of TIGIT has been demonstrated in both NK cells and T cells and plays a role in their activation and maturation. TIGIT competes with immunoactivator receptor CD226 (DNAM 1) for the same set of ligands: CD155 (PVR or poliovirus receptor) and CD112 (Nectin 2 or PVRL2) TIGIT's role in tumor immunosurveillance is analogous to the PD 1/PD L1 axis in tumor immunosuppression. Both TIGIT and PD 1 are upregulated in a variety of different cancers. Anti TIGIT antibodies have demonstrated synergy with anti PD 1/PD L1 antibodies in pre clinical models. Currently, there are multiple first in man phase I trials hoping to exploit this new pathway and improve response rates with existing immunotherapies.
A Model for Information Behavior Research on Social Live Streaming Services (SLSSs)
Venue: HCI
Year: 2018

Social live streaming services (SLSSs) are synchronous social media, which combine Live TV with elements of Social Networking Services (SNSs) including a backchannel from the viewer to the streamer and among the viewers. Important research questions are: Why do people in their roles as producers, consumers and participants use SLSSs? What are their motives? How do they look for gratifications, and how will they obtain them? The aim of this article is to develop a heuristic theoretical model for the scientific description, analysis and explanation of users' information behavior on SLSSs in order to gain better understanding of the communication patterns in real time social media. Our theoretical framework makes use of the classical Lasswell formula of communication, the Uses and Gratifications theory of media usage as well as the Self Determination theory. Albeit we constructed the model for understanding user behavior on SLSSs it is (with small changes) suitable for all kinds of social media.
Consumer Acceptance and Use of Information Technology: Adding consumption theory to UTAUT2
Year: 2011

This paper studies IT acceptance in a consumer context. It firstly takes economics factors into consideration, and proposes a theoretical model by incorporating consumption theory into UTAUT2 (which studies consumer acceptance by extending UTAUT) The consumption theory, which is prominent in Economics but not yet applied in IS, provides explanation for consumers' acceptance of technology. Consumption theory suggests income (absolute income, relative income, and permanent income) to be critical to consumersa intention. Our plan is to show that economic perspectives should be considered in analyzing consumers' acceptance and use of information technology, and empirically that the extended UTAUT2 with Consumption theory provides better explanatory value than UTAUT2 without the Consumption Theory, and generate theoretical and managerial implications for future
Classification model for imbalanced traffic data based on secondary feature extraction
Venue: IET Commun.
Year: 2017

The non equilibrium of network traffic data brings about the non equilibrium of classification. Feature extraction is an effective method to reduce data dimensions, while it can intensify the influence of non equilibrium further. A secondary feature extraction algorithm of multidimensional assessment is proposed in this study. The features of network traffic are evaluated in different dimensions to provide the basis for feature extraction. Furthermore, a model dealing with imbalanced data is proposed based on secondary feature extraction and sampling. The model combines the benefits of dimension reduction and redistribution. The experiment results show that the proposed model can not only increase classification accuracy and decrease non equilibrium, but also enhance the performance of different classification algorithms.
The risk perception paradox implications for governance and communication of natural hazards.
Venue: Risk analysis an official publication of the Society for Risk Analysis
Year: 2013

This article reviews the main insights from selected literature on risk perception, particularly in connection with natural hazards. It includes numerous case studies on perception and social behavior dealing with floods, droughts, earthquakes, volcano eruptions, wild fires, and landslides. The review reveals that personal experience of a natural hazard and trust or lack of trust in authorities and experts have the most substantial impact on risk perception. Cultural and individual factors such as media coverage, age, gender, education, income, social status, and others do not play such an important role but act as mediators or amplifiers of the main causal connections between experience, trust, perception, and preparedness to take protective actions. When analyzing the factors of experience and trust on risk perception and on the likeliness of individuals to take preparedness action, the review found that a risk perception paradox exists in that it is assumed that high risk perception will lead to personal preparedness and, in the next step, to risk mitigation behavior. However, this is not necessarily true. In fact, the opposite can occur if individuals with high risk perception still choose not to personally prepare themselves in the face of a natural hazard. Therefore, based on the results of the review, this article offers three explanations suggesting why this paradox might occur. These findings have implications for future risk governance and communication as well as for the willingness of individuals to invest in risk preparedness or risk mitigation actions.
MODEL SALES TERRITORY MANAGEMENT SEBAGAI BENTUK STRATEGI PEMASARAN (Studi Kasus Partner Trip Kota Malang)
Year: 2019

Penelitian ini bertujuan untuk menjelaskan model Sales Territory Management (STM) pada Partner Trip Kota Malang. Jenis penelitian adalah deskriptif dengan pendekatan kualitatif dan teknik pengumpulan data menggunakan wawancara mendalam yang dipandu dengan observasi dan dokumentasi. Informan dalam penelitian ini adalah owner and founder Partner Trip sebagai key person, seorang penanggung jawab bagian pemasaran, dua orang sales force, dan seorang staff pengantaran. Hasil penelitian menggambarkan bahwa sales territory management memiliki delapan elemen, yaitu visi dan misi, wilayah, strategi penjualan, sales force, strategi penggunaan saluran distribusi, channel, pola kerja sales force, dan kompetitor, serta memakai konsep Spreading, Coverage, and Penetration (SCP) Sedangkan sebagai strategi pemasaran, sales territory management direncanakan melalui lima tahapan, yaitu mapping, klasifikasi distributor, taking order, kegiatan delivery, dan kontrol pelaksanaan.  Strategi, Pemasaran,