nils-herrmann/clean_scirepeval huggingface dataset:
Response surface methodology and Taguchi approach to assess the combined effect of formulation factors on minocycline delivery from collagen sponges.
Venue: Die Pharmazie
Year: 2013

An important aspect to be considered in the healing of acute or chronic cutaneous wounds is the associated potential infection management. Collagen, the most abundant protein of the extracellular matrix, with proven properties in wounds healing and tissues regeneration, is one of the most widely used biopolymers as carrier matrix for controlled drug delivery systems. For this reason, the purpose of the current paper is the development of some minocycline loaded collagen topical sponges uncross linked and cross linked with glutaraldehyde, obtained by lyophilization of appropriate hydrogels prepared according to the 3 factor, 3 level face centered central composite design. The determination of drug delivery from the sponges was performed by assessment of some physicochemical parameters involved in this complex process: sponges surface wettability, swelling ratio and the percentage of minocycline released from the sponges. The application of the response surface methodology allowed the setting of the formulation parameters optimum ranges, which ensure an adequate minocycline release to the application site. The design robustness was checked using the signal to noise ratio performance indicator. The optimum collagen minocycline sponges determined based on the statistical screening technique could be suitable for topical drug delivery in infected wounds healing with moderate to high exudate.
Violence in the first millennium BCE Eurasian steppe: Cranial trauma in three Turpan Basin populations from Xinjiang, China.
Venue: American journal of physical anthropology
Year: 2020

Violence affected daily life in prehistoric societies, especially at conflict zones where different peoples fought over resources and for other reasons. In this study, cranial trauma was analyzed to discuss the pattern of violence experienced by three Bronze to early Iron Age populations (1,000 100 BCE) that belonged to the Subeixi culture. These populations lived in the Turpan Basin, a conflict zone in the middle of the Eurasian Steppe.  The injuries on 129 complete crania unearthed from the Subeixi cemeteries were examined for crude prevalence rate (CPR) trauma type, time of occurrence, possible weapon, and direction of the blow. Thirty three injuries identified from poorly preserved crania were also included in the analyses except for the CPR. Data was also compared between the samples and with four other populations that had violence related backgrounds.  Overall, 16.3% (21/129) of the individuals showed violence induced traumatic lesions. Results also indicated that most of the injuries were perimortem (81.6% and that women and children were more involved in conflict than the other comparative populations. Wounds from weapons accounted for 42.1% of the identified cranial injuries. Distribution analysis suggested no dominant handedness of the attackers, and that blows came from all directions including the top (17.1% Wounds caused by arrowheads and a special type of battle ax popular in middle and eastern Eurasian Steppe were also recognized.  A comprehensive analysis of the skeletal evidence, historical records, and archeological background would suggest that the raiding to be the most possible conflict pattern reflected by the samples. The attackers were likely to have been nomadic invaders from the steppe (such as the Xiongnu from historical records) who attacked the residents in the basin more likely for their resources rather than territory or labor force.
A modeling framework for business process reengineering using big data analytics and a goal orientation
Venue: 2017 11th International Conference on Research Challenges in Information Science (RCIS)
Year: 2017

A business process is a collection of activities to create more business values and its continuous improvement aligned with business goals is essential to survive in fast changing business environment. However, it is quite challenging to find out whether a change of business processes positively affects business goals or not, if there are problems in the changing, what the reasons of the problems are, what solutions exist for the problems and which solutions should be selected. Big data analytics along with a goal orientation which helps find out insights from a large volume of data in a goal concept opens up a new way for an effective business process reengineering. In this paper, we suggest a novel modeling framework which consists of a conceptual modeling language, a process and a tool for effective business processes reengineering using big data analytics and a goal oriented approach. The modeling language defines important concepts for business process reengineering with metamodels and shows the concepts with complementary views: Business Goal Process Big Analytics Alignment View, Transformational Insight View and Big Analytics Query View. Analyzers hypothesize problems and solutions of business processes by using the modeling language, and the problems and solutions will be validated by the results of Big Analytics Queries which supports not only standard SQL operation, but also analytics operation such as prediction. The queries are run in an execution engine of our tool on top of Spark which is one of big data processing frameworks. In a goal oriented spirit, all concepts not only business goals and business processes, but also big analytics queries are considered as goals, and alternatives are explored and selections are made among the alternatives using trade off analysis. To illustrate and validate our approach, we use an automobile logistics example, then compare previous work.
A INTERPRETACAO KANTIANA DO FINALISMO EM SPINOZA NA TERCEIRA CRITICA
Year: 2018

Segundo Spinoza (1632 1677) nao existe finalismo na natureza, pois seria uma ignorancia atribuir intencionalidade a realidade que, segundo sua ontologia, e uma substancia (Deus) Por sua vez, Kant (1724 1804) considerou o juizo teleologico como a possibilidade de refletirmos uma finalidade na natureza, nao como um fim terminal ou em si mesmo a partir de um Deus criador, mas atraves do homem, que tem a faculdade de julgar compreendendo as relacoes das partes com o todo. O objetivo deste artigo e apresentar uma analise critica de Kant a ontologia de Spinoza no que se refere ao problema do finalismo. Ou seja, a partir da leitura de algumas passagens da Segunda Parte (Critica da Faculdade de Juizo Teleologica) da Critica da Faculdade do Juizo, explicitar a critica kantiana a critica ao finalismo em Spinoza desenvolvida na Parte I de sua Etica. Conclui se que, a interpretacao critica de Kant (partindo do pressuposto do juizo teleologico) a ontologia antifinalista de Spinoza considerou alguns paradoxos, como o panteismo e o fatalismo decorrentes da substancia divina e a falta de uma explicacao acerca do sistema de conformidade a fins na natureza, marcado por um idealismo que negava qualquer tipo de intencionalidade ou fim da natureza.
Increased serum concentration of ceramides in obese children with nonalcoholic fatty liver disease
Venue: Lipids in Health and Disease
Year: 2018

BackgroundHepatic lipid accumulation is closely related to the development of insulin resistance, which is regarded as one of the most significant risk factors of nonalcoholic fatty liver disease (NAFLD) Although the exact molecular pathway leading to impaired insulin signaling has not been definitively established, ceramides are suspected mediators of lipid induced hepatic insulin resistance. Therefore, the aim of the study was to evaluate the serum ceramides concentration in obese children with NAFLD.MethodsThe prospective study included 80 obese children (aged 7 17 years, median 12 years) admitted to our Department to diagnose initially suspected liver disease. Patients with viral hepatitis (HCV, HBV, CMV) autoimmune (AIH) toxic and metabolic (Wilson's disease, alfa 1 antitrypsin deficiency) liver diseases and celiac disease were excluded. NAFLD was diagnosed based on pediatric diagnostic criteria in obese children with liver steatosis in ultrasound (US) as well as elevated alanine transaminase (ALT) serum activity after exclusion of other major liver diseases listed before. Ultrasonography was used as a screening method and for qualitative assessment of the steatosis degree (graded according to Saverymuttu scale) Advanced steatosis was defined as a score 1. The total intrahepatic lipid content (TILC) was assessed by magnetic resonance proton spectroscopy (1HMRS) which is the most accurate technique for assessment of ectopic fat accumulation. Fasting serum concentration of ceramides was measured in 62 children.ResultsNAFLD was diagnosed in 31 children. Significant, positive correlation was found between total serum concentration of ceramides and insulin (r 0.3, p 0.02) and HOMA IR (r 0.28, p 0.03) Total ceramide concentration as well as specific fatty acid ceramides (FA ceramides) concentrations, namely: myristic, palmitic, palmitoleic, stearic, oleic, behenic and lignoceric were significantly higher (p 0.004, p 0.003, p 0.007, p 0.001, p 0.035, p 0.008, p 0.003, p 0.006, respectively) in children with NAFLD compared to controls (n 14) Moreover, children with NAFLD had significantly higher activity of ALT (p 0.001) and GGT (p 0.001) HOMA IR (p 0.04) BMI (p 0.046) waist circumference (p 0.01) steatosis grade in ultrasound (p 0.001) and TILC in 1HMRS (p 0.001) compared to children without NAFLD. We did not find significant differences in total and FA ceramide species concentrations between children with mild (grade 1) and advanced liver steatosis in ultrasonography (grade 2 3).ConclusionElevated ceramide concentrations in obese patients together with their significant correlation with insulin resistance parameters suggest their association with molecular pathways involved in insulin signaling impairment known to be strongly linked to pathogenesis of non alcoholic fatty liver disease.
An Application of Six Sigma to Reduce Supplier Quality Cost
Year: 2016

This article presents an application of Six Sigma to reduce supplier quality cost in manufacturing industry. Although there is a wider acceptance of Six Sigma in many organizations today, there is still a lack of in depth case study of Six Sigma. For the present research the case study methodology was used. The company decided to reduce quality cost and improve selected processes using Six Sigma methodologies. Regarding the fact that there is a lack of case studies dealing with Six Sigma especially in individual manufacturing organization this article could be of great importance also for the practitioners. This paper discusses the quality and productivity improvement in a supplier enterprise through a case study. The paper deals with an application of Six Sigma define measure analyze improve control methodology in an industry which provides a framework to identify, quantify and eliminate sources of variation in an operational process in question, to optimize the operation variables, improve and sustain performance viz. process yield with well executed control plans. Six Sigma improves the process performance (process yield) of the critical operational process, leading to better utilization of resources, decreases variations and maintains consistent quality of the process output.
Odour annoyance in the neighbourhood of livestock farming perceived health and health care seeking behaviour.
Venue: Annals of agricultural and environmental medicine AAEM
Year: 2015

Odour annoyance forms the main source of environmental stress in residents living in the proximity of animal feeding operations (AFOs) and it has been associated with reduced health. This study aims to gain more insight into the association between AFOs in the neighbourhood, odour annoyance, other environmental stressors, and health, and incorporates health care seeking behaviour for reported symptoms.  Odour and other environmental annoyances in the neighbourhood, general health and symptom reporting were obtained by questionnaire. Health care utilisation was obtained from electronic medical records of general practices. The number of pigs, poultry and cattle within a 500 m radius from homes was computed using Geographic Information System data. Mutually adjusted multiple Poisson and (ordinal) logistic regression analyses were performed.  The number of pigs, poultry and cattle was equally associated with odour annoyance. This annoyance was associated with reduced general health and increased reporting of respiratory, gastrointestinal, neurological and stress related symptoms. Participants rarely consulted their general practitioner for reported symptoms. Environmental stressors were weakly associated.  The number of animals around the homes was associated with odour annoyance. Odour annoyance was associated with reduced health, which could be a reason for caution with the construction of new AFOs.
Using COBIT and ITIL frameworks to establish the alignment of business and IT organizations as one of the critical success factors in ERP implementation
Venue: The 5th Conference on Information and Knowledge Technology
Year: 2013

Nowadays, the use of Enterprise Resource Planning systems (ERP) are spreading widely in organizations. Until now many of the key factors for successful implementation of ERP in an organization has been interest of researchers. Organizations are trying, to reduce costs, increase productivity and increase profits by using of integrated ERP systems. Furthermore, alignment between business and information technology cause to reduce costs, increase flexibility and responsiveness of the organization, creating added value, create competitive advantage and optimize resources investigation. Alignment between business and IT in the organization is one of the key success factors of ERP implementations in organizations, that in this paper we are intended to achieve this goal by using COBIT and ITIL frameworks.
Contesting the Neoliberal Discourse of the World Class University: 'Digital Socialism' Openness and Academic Publishing
Year: 2020

The principal aim of this paper is to contest the neoliberal discourse of the World Class University (WCU) The first section provides an understanding of the concept of the WCU within the context of a global competitive model of the knowledge economy and contrasts it with the social democratic model based on open science and education that also provides links between new modes of openness, academic publishing and the world journal architecture. The paper makes the case for 'knowledge socialism' that accurately depicts the greater communitarian moment of the sharing and participative academic economy based on peer to peer production, social innovation and collective intelligence. It instantiates the notion of knowledge as a global public good. Profound changes in the nature of technology has enabled a kind of 'digital socialism' which is clearly evident in the shift in political economy of academic publishing based Open Access, cOAlition S, and 'Plan S' (mandated in 2020) established by national research funding organisations in Europe with the support of the European Commission and the European Research Council (ERC) The social democratic alternative to neoliberalism and the WCU is a form of the sharing academic economy known as 'knowledge socialism' Universities need to share knowledge in the search for effective responses to pressing world problems of fragile global ecologies and the growing significance of technological unemployment. This is a model that proceeds from a very different set of economic and moral assumptions than the neoliberal knowledge economy and the WCU.
Perfil neuropsicologico de ninos con dislalias: alteraciones mnesicas y atencionales
Year: 2014

In this study we investigate the neuropsychological functioning of children with dyslalias. 34 children with multiple dyslalia (articulatory distortion or substitution of three phonemes: r l and s and normal neurological examination. 28 children without speech problems are used as reference group. The neuropsychological profile is estimated using the Wechsler Intelligence Scale for Children Revised (WISC R) and Luria Neuropsychological Battery DNI. We found in children with dyslalias: A) The memory profile deteriorated globally in respect to the reference group but are preserved remote memory and the memory of shapes. B) kinesthesia and estereognosia disorders. C) Attentional disorders. We found mnemonic and attentional problems in children with dyslalias similar to those children with language problems secondary to brain damage or affect organs or major psycholinguistic disorders. We consider this neuropsychological profile deteriorated in neurological and psychoeducational counseling, which would justify the treatment and neuropsychological rehabilitation of memory and attention.
Synthesis of CoFe2O4/C nano catalyst with excellent performance by molten salt method and its application in 4 nitrophenol reduction.
Venue: Environmental pollution
Year: 2019

CoFe2O4/C nano sheets (NSs) have been synthesized by a facile molten salt method using cheap potassium fulvate as carbon source and sodium chloride as template. The morphology, crystallinity and composition of the materials were analyzed by TEM, XRD and XPS. The study on the catalytic performance of 4 nitrophenol (4 NP) shows that CoFe2O4/C 600 nano catalyst has the highest catalytic activity and the corresponding apparent constant is 1.91 min 1, this result is higher than that reported in most literatures. Catalytic kinetics of 4 NP reduction was studied in this article, and activation energy (Ea) was calculated to be 14.31 kJ mol 1. The catalyst also shows good cycle performance and stability. This convenient method provides a reference for the synthesis of MFe2O4/C and other nano metal oxides/C nanocomposite catalysts.
eso Neoproterozoic petroleum systems of the Eastern Siberian edimentary basins ergei
Year: 2015

The elements of the petroleum systems of the Siberian platform have been formed in the course of geological evolution in Mesoand Neoproterozoic time and correspond to the supercontinent stage from assembly of Paleo Mesoproterozoic Columbia to break up of Neoproteorzoic Rodinia. Several large sedimentary basins were established within the Siberian craton during the Riphean. A number of passive continental margin basins (the Turukhansk, Cis Patom basins and others) developed on the southern, western, and, probably, northern craton peripheries. Several other basins, such as the Irkineeva Vanavara, Kotuy, Anabar Kureika, and Udzha basins, were entirely intracratonic. The structural patterns of these basins and their petroleum systems were essentially affected by Baikalian orogeny events with intensive dislocations and erosion of Riphean series, especially along the margins of the continent. As a result, hydrocarbon accumulations formed by the source rocks, which have realized their potential in Riphean within the margin basins, were, most likely, completely destroyed. Vendian and Lower Cambrian deposits were the main source for present day oil fields of the central and northern parts of the Nepa Botuoba Anteclise and the Turukhansk Uplift. The Upper Riphean source rocks of the intracratonic basins, on the contrary, are unlikely to be affected by the significant pre Vendian erosion and, thus, could be a source for the oil fields of the Yurubchen Tokhomo Zone and the Katanga Saddle. Such difference in petroleum system evolution for different basins is also supported by results of oil source rock correlations based on biomarker studies. A new mega cycle of formation of the sedimentary cover started on the Siberian platform in the Vendian (Ediacaran) The initial fabric of all the main structural elements of the platform was established at this time. The large Vendian depressions (the "prototypes" of Paleozoic Kureika and Cis Sayan Yenisei syneclises and Cis Patom Trough) were areas of mainly marine sedimentation where the high potential hydrocarbon source series could be deposited. Large elevated areas served as a terrigenous provenance in the Early Vendian resulting in a large amount of clastic material deposited along their flanks. The most promising areas for new discoveries of hydrocarbon fields are in the slopes of the Baikit, Nepa Botuoba and Anabar anticlises faced towards the Kureika Syneclise.
Change in self efficacy, eating behaviors and food cravings during two years of calorie restriction in humans without obesity
Venue: Appetite
Year: 2019

Calorie restriction (CR) enhances longevity in humans who are normal weight, overweight and obese. While dietary regimens can change self efficacy, eating behaviors, and food cravings in individuals with obesity, the responses of these measures to prolonged CR in individuals who are exclusively not obese is unknown. The aim of this analysis was to test the effects of a two year CR intervention on self efficacy and eating attitudes and behaviors in humans without obesity by analyzing data from the Comprehensive Assessment of Long term Effects of Reducing Intake of Energy Phase 2 (CALERIE 2) study. Participants (n 218, BMI range 21.3 29.0 kg/m2) were randomized to a 25% CR group or an ad libitum (AL) group. Eating attitudes and behaviors and self efficacy were assessed using validated questionnaires at baseline, 12, and 24 months. Dietary restraint and self efficacy increased in the CR compared to the AL group (ES 0.32) Increased self efficacy was negatively related to weight change (r 0.24) In the CR group, males showed a reduction in cravings for carbohydrates and fats at month 24, whereas females did not. The CR group showed elevations in state hunger, which were transient, and disinhibited eating (ES 0.37) In individuals without obesity, dietary restraint and self efficacy could be important in promoting long term CR for individuals looking to use CR as a tool to improve longevity.
BERTTune: Fine Tuning Neural Machine Translation with BERTScore
Venue: ACL/IJCNLP
Year: 2021

Neural machine translation models are often biased toward the limited translation references seen during training. To amend this form of overfitting, in this paper we propose fine tuning the models with a novel training objective based on the recently proposed BERTScore evaluation metric. BERTScore is a scoring function based on contextual embeddings that overcomes the typical limitations of n gram based metrics (e.g. synonyms, paraphrases) allowing translations that are different from the references, yet close in the contextual embedding space, to be treated as substantially correct. To be able to use BERTScore as a training objective, we propose three approaches for generating soft predictions, allowing the network to remain completely differentiable end to end. Experiments carried out over four, diverse language pairs have achieved improvements of up to 0.58 pp (3.28% in BLEU score and up to 0.76 pp (0.98% in BERTScore (FBERT when finetuning a strong baseline.