nils-herrmann/clean_scirepeval huggingface dataset:
Distinguishing the co ancestries of haplogroup G Y chromosomes in the populations of Europe and the Caucasus
Venue: European Journal of Human Genetics
Year: 2012

Haplogroup G, together with J2 clades, has been associated with the spread of agriculture, especially in the European context. However, interpretations based on simple haplogroup frequency clines do not recognize underlying patterns of genetic diversification. Although progress has been recently made in resolving the haplogroup G phylogeny, a comprehensive survey of the geographic distribution patterns of the significant sub clades of this haplogroup has not been conducted yet. Here we present the haplogroup frequency distribution and STR variation of 16 informative G sub clades by evaluating 1472 haplogroup G chromosomes belonging to 98 populations ranging from Europe to Pakistan. Although no basal G M201* chromosomes were detected in our data set, the homeland of this haplogroup has been estimated to be somewhere nearby eastern Anatolia, Armenia or western Iran, the only areas characterized by the co presence of deep basal branches as well as the occurrence of high sub haplogroup diversity. The P303 SNP defines the most frequent and widespread G sub haplogroup. However, its sub clades have more localized distribution with the U1 defined branch largely restricted to Near/Middle Eastern and the Caucasus, whereas L497 lineages essentially occur in Europe where they likely originated. In contrast, the only U1 representative in Europe is the G M527 lineage whose distribution pattern is consistent with regions of Greek colonization. No clinal patterns were detected suggesting that the distributions are rather indicative of isolation by distance and demographic complexities.
A Deep Learning Based Method for Overhead Contact System Component Recognition Using Mobile 2D LiDAR
Venue: Sensors
Year: 2020

The overhead contact system (OCS) is a critical railway infrastructure for train power supply. Periodic inspections, aiming at acquiring the operational condition of the OCS and detecting problems, are necessary to guarantee the safety of railway operations. One of the OCS inspection means is to analyze data of point clouds collected by mobile 2D LiDAR. Recognizing OCS components from the collected point clouds is a critical task of the data analysis. However, the complex composition of OCS makes the task difficult. To solve the problem of recognizing multiple OCS components, we propose a new deep learning based method to conduct semantic segmentation on the point cloud collected by mobile 2D LiDAR. Both online data processing and batch data processing are supported because our method is designed to classify points into meaningful categories of objects scan line by scan line. Local features are important for the success of point cloud semantic segmentation. Thus, we design an iterative point partitioning algorithm and a module named as Spatial Fusion Network, which are two critical components of our method for multi scale local feature extraction. We evaluate our method on point clouds where sixteen categories of common OCS components have been manually labeled. Experimental results show that our method is effective in multiple object recognition since mean Intersection over Unions (mIoUs) of online data processing and batch data processing are, respectively, 96.12% and 97.17%
Phase 3 randomized, placebo controlled study of galcanezumab in patients with chronic cluster headache: Results from 3 month double blind treatment
Venue: Cephalalgia an international journal of headache
Year: 2020

To report efficacy and safety of galcanezumab in adults with chronic cluster headache.  Galcanezumab is a humanized monoclonal antibody that binds to calcitonin gene related peptide and inhibits its biological activity.  This study comprised a prospective baseline period, a 12 week double blind, placebo controlled treatment period, and a 52 week open label period. Up to six protocol specified concomitant preventive medications were allowed if patients were on a stable dose for 2 months prior to the prospective baseline period. Patients were randomized 1:1 to monthly subcutaneous galcanezumab (300 mg) or placebo. The primary endpoint was overall mean change from baseline in weekly attack frequency with galcanezumab compared to placebo. Key secondary endpoints were =50% response rate and percentage of patients meeting sustained response. Results from the double blind treatment period are reported.  A total of 237 patients were randomized and treated (120 placebo; 117 galcanezumab) At baseline, the mean age was 45 years and 63% were using =1 preventive drug. The primary endpoint was not met; mean change in weekly attack frequency was 4.6 placebo versus 5.4 galcanezumab (p 0.334) Key secondary endpoints also were not met. Injection site related treatment emergent adverse events were more common in the galcanezumab than the placebo group, with significantly more injection site erythema.  Treatment with galcanezumab 300 mg did not achieve its primary and key secondary endpoints. This study underscores the potential distinct biology of cCH as well as the significant unmet need for safe, effective, and well tolerated preventive treatment. The safety profile of galcanezumab in cCH is consistent with that observed in trials of episodic CH and migraine.
La psychomotricite aupres de la personne agee demente anxieuse en EHPAD les mediations bain et toucher therapeutique comme supports de l'accompagnement
Year: 2015

La demence, en plus d'etre a l'origine de troubles cognitifs, a des repercussions sur l'autonomie du sujet qui en est atteint. Elle vient ainsi se greffer a son identite de sujet vieillissant. La situation de vulnerabilite dans laquelle la demence plonge le sujet engendre chez lui des comportements dits productifs ou perturbateurs Ils sont regroupes sous le terme de symptomes psychologiques et comportementaux de la demence (SPCD) dont fait partie l'anxiete. Ce memoire propose une lecture psychomotrice du vecu anxieux de la personne agee demente en EHPAD. Il s'agit d'une reflexion theorique et clinique sur l'interet des mediations bain et toucher therapeutiques comme supports de la prise en soin.
AI Driven Zero Touch Network and Service Management in 5G and Beyond: Challenges and Research Directions
Venue: IEEE Network
Year: 2020

The foreseen complexity in operating and managing 5G and beyond networks has propelled the trend toward closed loop automation of network and service management operations. To this end, the ETSI Zero touch network and Service Management (ZSM) framework is envisaged as a next generation management system that aims to have all operational processes and tasks executed automatically, ideally with 100 percent automation. Artificial Intelligence (AI) is envisioned as a key enabler of self managing capabilities, resulting in lower operational costs, accelerated time tovalue and reduced risk of human error. Nevertheless, the growing enthusiasm for leveraging AI in a ZSM system should not overlook the potential limitations and risks of using AI techniques. The current paper aims to introduce the ZSM concept and point out the AI based limitations and risks that need to be addressed in order to make ZSM a reality.
Effect of High Dose vs Standard Dose Vitamin D3 Supplementation on Progression Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial
Venue: JAMA
Year: 2019

In observational studies, higher plasma 25 hydroxyvitamin D (25[OH]D) levels have been associated with improved survival in metastatic colorectal cancer (CRC)  To determine if high dose vitamin D3 added to standard chemotherapy improves outcomes in patients with metastatic CRC.  Double blind phase 2 randomized clinical trial of 139 patients with advanced or metastatic CRC conducted at 11 US academic and community cancer centers from March 2012 through November 2016 (database lock: September 2018) Interventions mFOLFOX6 plus bevacizumab chemotherapy every 2 weeks and either high dose vitamin D3 (n 69) or standard dose vitamin D3 (n 70) daily until disease progression, intolerable toxicity, or withdrawal of consent.  The primary end point was progression free survival (PFS) assessed by the log rank test and a supportive Cox proportional hazards model. Testing was 1 sided. Secondary end points included tumor objective response rate (ORR) overall survival (OS) and change in plasma 25(OH)D level.  Among 139 patients (mean age, 56 years; 60 [43% women) who completed or discontinued chemotherapy and vitamin D3 (median follow up, 22.9 months) the median PFS for high dose vitamin D3 was 13.0 months (95% CI, 10.1 to 14.7; 49 PFS events) vs 11.0 months (95% CI, 9.5 to 14.0; 62 PFS events) for standard dose vitamin D3 (log rank P .07) multivariable hazard ratio for PFS or death was 0.64 (1 sided 95% CI, 0 to 0.90; P .02) There were no significant differences between high dose and standard dose vitamin D3 for tumor ORR (58% vs 63% respectively; difference, 5% [95% CI, 20% to 100% P .27) or OS (median, 24.3 months vs 24.3 months; log rank P .43) The median 25(OH)D level at baseline for high dose vitamin D3 was 16.1 ng/mL vs 18.7 ng/mL for standard dose vitamin D3 (difference, 2.6 ng/mL [95% CI, 6.6 to 1.4] P .30) at first restaging, 32.0 ng/mL vs 18.7 ng/mL (difference, 12.8 ng/mL [95% CI, 9.0 to 16.6] P .001) at second restaging, 35.2 ng/mL vs 18.5 ng/mL (difference, 16.7 ng/mL [95% CI, 10.9 to 22.5] P .001) and at treatment discontinuation, 34.8 ng/mL vs 18.7 ng/mL (difference, 16.2 ng/mL [95% CI, 9.9 to 22.4] P .001) The most common grade 3 and higher adverse events for chemotherapy plus high dose vs standard dose vitamin D3 were neutropenia (n 24 [35% vs n 21 [31% respectively) and hypertension (n 9 [13% vs n 11 [16% Conclusions and Relevance Among patients with metastatic CRC, addition of high dose vitamin D3, vs standard dose vitamin D3, to standard chemotherapy resulted in a difference in median PFS that was not statistically significant, but with a significantly improved supportive hazard ratio. These findings warrant further evaluation in a larger multicenter randomized clinical trial.
A Manet Based Emergency Communication System for Environmental Hazards Using Opportunistic Routing
Venue: 2020 International Conference in Mathematics, Computer Engineering and Computer Science (ICMCECS)
Year: 2020

Environmental hazard is very challenging when it comes to providing support to the affected areas due to the lack of effective communication. Communication infrastructures such as cellular networks might be destroyed, disabled, partially accessible, or deliberately shut down during environmental hazards. As a result, hundreds of people die before they have a chance to be saved. This paper proposes an emergency management system using a network of mobile devices that can be implemented in areas affected by disasters. Both stranded survivors and rescue teams can use this technology. The proposed system provides an emergency communication network when all modes of communication infrastructure are broken down. For path discovery and message transmission, a wireless self organized, opportunistic routing protocol is also proposed.
Roads to Multimedia Broadcast Multicast Services in 5G New Radio
Venue: 2018 IEEE International Symposium on Broadband Multimedia Systems and Broadcasting (BMSB)
Year: 2018

Broadcast and multicast represent a key opportunity in 5G for the massive consumption of multimedia services in the near future. These technologies permit to offload an important portion of this traffic in peak demand scenarios where users are consuming parallel content. An initial specification of 5G New Radio (NR) Rel'15 was delivered in December 2017 and the final version will be published in June this year. However, 3GPP has not yet defined any broadcast/multicast solution for Rel'15 NR, although some proposals will be revisited as soon as time units in Rel'16 become available. In this work, we analyze the use of a mixed mode that shares multicast, broadcast and unicast resources via the same physical channel. This technology, as well as its LTE counterpart, is evaluated through link level air interface and subsequently system level simulations, providing an objective insight roads to MBMS provision in 5G NR.
Index modulation techniques for 5G wireless networks
Venue: IEEE Communications Magazine
Year: 2016

The ambitious goals set for 5G wireless networks, which are expected to be introduced around 2020, require dramatic changes in the design of different layers for next generation communications systems. Massive MIMO systems, filter bank multi carrier modulation, relaying technologies, and millimeter wave communications have been considered as some of the strong candidates for the physical layer design of 5G networks. In this article, we shed light on the potential and implementation of IM techniques for MIMO and multi carrier communications systems, which are expected to be two of the key technologies for 5G systems. Specifically, we focus on two promising applications of IM: spatial modulation and orthogonal frequency division multiplexing with IM, and discuss the recent advances and future research directions in IM technologies toward spectrum and energy efficient 5G wireless networks.
Hubungan Tingkat Pengetahuan dan Keteraturan Kunjungan di Posyandu Lansia Kelurahan Cangkrep Lor Kabupaten Purworejo
Year: 2018

ABSTRAK Latar Belakang Posyandu lansia adalah program pemerintah untuk mengatasi masalah utama para lanjut usia tentang pemenuhan kebutuhan pelayanan kesehatan. Salah satu faktor yang mempengaruhi keteraturan kunjungan adalah pengetahuan lansia tentang posyandu lansia. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dan keteraturan kunjungan di posyandu lansia. Metode Desain penelitian observasional analitik dengan pendekatan cross sectional. Teknik sampling menggunakan Purposive sampling. Sampel adalah 30 lansia yang memenuhi kriteria retriksi. Teknik pengumpulan data menggunakan hasil dari kuesioner tentang posyandu lansia dan data pada buku register. Teknik analisis data menggunakan korelasi Lamda Hasil Tingkat pengetahuan lansia pada kategori baik sebanyak 11 responden (36,67% dan keteraturan kunjungan yang teratur sebanyak 16 responden (53,33% Berdasarkan analisis responden yang mempunyai pengetahuan baik dan teratur berkunjung sebanyak 9 responden (81,81% Berdasarkan analisis data menggunakan uji Lamda diperoleh hasil p 0,043, r 0,500. Hal ini menunjukkan adanya hubungan positif antara tingkat pengetahuan dan keteraturan kunjungan dengan kekuatan sedang.Simpulan Terdapat hubungan yang bermakna antara tingkat pengetahuan dan keteraturan kunjungan di Posyandu Lansia Kelurahan Cangkrep Lor Kabupaten Purworejo. Kata Kunci Tingkat Pengetahuan, keteraturan kunjungan, Lansia
The ancient Egyptian state the origins of Egyptian culture (c. 8,000 2,000 BC)
Year: 2009

1. The significance and interpretation of Ancient Egyptian civilization 2. Introduction to the Ancient Egyptians and their country 3. Introduction to the evidence and interpretation of Egyptian antiquity 4. The neolithic and early predynastic origins of pharaonic civilization 5. Lords of the two lands the origins of the first pharaonic states 6. The pharaonic state in early maturity 7. Egypt and general analyses of state origins.
Optimization of Fuel Cell and Supercapacitor for Fuel Cell Electric Vehicles
Venue: IEEE Transactions on Vehicular Technology
Year: 2006

In this paper, an optimal design to minimize the cost of the fuel cell and supercapacitor in a fuel cell electric vehicle is presented. It is assumed that the cost of the fuel cell and supercapacitor is a function of the number of units of each, respectively. The constraints on the number of fuel cell units and supercapacitor units are derived according to the system requirement of maintaining stable dc link voltage for all possible vehicle operations. These constraints are combined with the derived cost function to obtain the optimal number of fuel cell units and supercapacitor units and the minimum cost. The cost, volume, and weight of the optimized fuel cell and supercapacitor of the powertrain and the fuel economy of the vehicle are evaluated. Simulation results are presented to verify the design
Non isothermal Simulation of a Two lumen Catheter Tubing Extrusion for a Die Design
Year: 2019

Catheter tubing is manufactured by an extrusion process. In this study, two types of extrusion dies that were used in catheter tubing extrusion were compared through non isothermal computer simulation. The two types of dies were a straight die and a crosshead die. The straight die is attached to the extruder in the same line while the crosshead die is attached to the extruder at a right angle. The pressure distribution, velocity distribution, temperature distribution, and shear stress distribution in the two types of dies were analyzed and compared through computer simulation. Flow characteristics and temperature stabilities were examined and subsequently the adequacy of extruders for the two dies was discussed. The straight die had the advantage of a smooth and balanced flow, while the crosshead die had the advantage of a low shear stress generation that influenced the tubing quality.
Managing the Transition from Concussion to Return to Learn in Postsecondary Education: Strategies Based on Principles of UDL.
Year: 2018

Concussion is a functional brain injury that can produce physical, cognitive, emotional and sleep related symptoms. With correct management, most symptoms will resolve within a month and a gradual, progressive return to activity (cognitive and physical) that allows students to stay below the thresholds that make symptoms worse, can be started after the immediate post impact rest period of 24 48 hours. The 6 step Return to Learn protocol works well to manage the return to the classroom for elementary and high school aged students, however it is difficult to implement in a postsecondary setting, as it requires a level of monitoring not generally available through college or university student wellness centres. As a result, course instructors are often given the task of providing accommodations to help students recovering from concussion manage and master the content and complete the required work to pass their course. This paper will discuss the challenges facing the postsecondary student recovering from concussion and provide accommodation ideas and examples, with resources, that instructors may find helpful.
SAT Based Encodings for Optimal Decision Trees with Explicit Paths
Venue: SAT
Year: 2020

Decision trees play an important role both in Machine Learning and Knowledge Representation. They are attractive due to their immediate interpretability. In the spirit of Occam's razor, and interpretability, it is desirable to calculate the smallest tree. This, however, has proven to be a challenging task and greedy approaches are typically used to learn trees in practice. Nevertheless, recent work showed that by the use of SAT solvers one may calculate the optimal size tree for real world benchmarks. This paper proposes a novel SAT based encoding that explicitly models paths in the tree, which enables us to control the tree's depth as well as size. At the level of individual SAT calls, we investigate splitting the search space into tree topologies. Our tool outperforms the existing implementation. But also, the experimental results show that minimizing the depth first and then minimizing the number of nodes enables solving a larger set of instances.
Association Between Objectively Measured Physical Activity and the Number of Chronic Musculoskeletal Pain Sites in Community Dwelling Older Adults
Venue: Pain medicine
Year: 2019

Physical inactivity is recognized as a pandemic health problem. The association of pain with physical activity, particularly when measured objectively, in older adults is unclear. This study investigates the association of number of chronic musculoskeletal pain sites and pain severity with objectively measured physical activity in community dwelling older adults.  Observational study.   We analyzed 267 community dwelling older adults (mean age 75.3 years, 67.0% women)  Number of chronic musculoskeletal pain sites and pain severity were measured using a self reported questionnaire. Mean steps per day and mean minutes of light physical activity per day and moderate to vigorous physical activity per day were measured using an accelerometer. Linear regression models were applied to analyze the association of number of chronic musculoskeletal pain sites and pain severity with physical activity.  The results suggest that a higher number of chronic musculoskeletal pain sites is associated with lower step count (beta 333.5, 95% confidence interval 655.9 to 11.0, P 0.05) and moderate to vigorous physical activity (beta 2.5, 95% confidence interval 4.7 to 0.4, P 0.05) even after adjustment for age, gender, years of schooling, obesity, alcohol habits, smoking status, number of comorbidities, recent surgery, and depressive symptoms.  Our results suggest that the number of chronic musculoskeletal pain sites is associated with low physical activity in older adults. Therefore, low physical activity due to chronic musculoskeletal pain should not be overlooked.
Effect of Tillage and Residue Management on Productivity of Crops in Rice Wheat Cropping System
Year: 2018

Rice (Oryza sativa L. and wheat (Triticum aestivum L. emend Fiori and Paol. are major cereals contributing to food security and income in South Asia. These crops are grown either as a monoculture or in rotations in tropical and subtropical environments of South Asia. In the irrigated and favorable rainfed lowland areas, rice rice (R R) and ricewheat (R W) are the predominant cropping systems  Rice wheat is the most important cropping system for food security in South Asia (13.5 M ha) providing food for more than 400 million people. It gained prominence from the mid 1960s with the introduction of short duration and high yielding varieties of rice and wheat. At the moment, the rotation has spread in the most fertile regions and has covered about 10.3 million ha in the Indo Gangetic Plain (IGP) of India  It is more popular in the non traditional rice growing states of Punjab, Haryana and Uttar Pradesh, and less in traditional rice growing states of Bihar and West Bengal. In India, it contributes 26% of total cereal production and 60% of total calorie intake  The area under this system is static, and the productivity and sustainability of the system are threatened because of the inefficiency of current production practices, shortage of resources, such as water and labour, fuel and socio economic changes