nils-herrmann/clean_scirepeval huggingface dataset:
Fiabilidad y validez del cuestionario OSDI (Ocular Disease Surface Index) en pacientes con diagnostico de sindrome de ojo seco en el Hospital Simon Bolivar, Colombia
Year: 2018

La enfermedad de superficie ocular, como actualmente se le conoce al sindrome de ojo seco, ocupa dentro de la morbilidad ocular uno de los principales motivos de consulta, la cual genera multiple sintomatologia con un importante impacto en la calidad de vida de los pacientes.  Validar transculturalmente el cuestionario OSDI (Ocular Surface Disease Index) en pacientes diagnosticados con sindrome de ojo seco atendidos en la consulta de oftalmologia en el servicio del Hospital Simon Bolivar, Bogota, Colombia. Materiales y Metodos Se realizo la traduccion del cuestionario OSDI, y se puso en consideracion de expertos en el tema y posteriormente se realizo la aplicacion del mismo a un total de 132 pacientes con diagnostico de ojo seco, luego se hizo un re test aplicando nuevamente la escala a las dos semanas, y finalmente se realizo la tabulacion y analisis estadistico.  Se identificaron 3 subescalas en el cuestionario OSDI (sintomatologia, limitacion para actividades diarias y afectacion por condiciones ambientales) Se demostro una alta consistencia interna medida a traves del coeficiente alfa de Cronbach tanto para el instrumento en general como para cada una de sus subescalas. De igual forma se obtuvo una excelente fiabilidad test retest en una amplia muestra de pacientes. El OSDI tambien demostro excelente validez al discriminar de manera efectiva los grados de severidad de la enfermedad de superficie ocular y su afectacion en la calidad de vida de los pacientes entre normal, leve a moderada y severa determinada por la escala de color y puntuacion. Conclusiones La escala OSDI es un instrumento valido y fiable que permite su aplicacion a la poblacion del servicio de Oftalmologia del Hospital Simon Bolivar con diagnostico de enfermedad de superficie ocular con el cual se obtendran datos de gran importancia para el abordaje y manejo de cada uno de los pacientes.
Mythbusters: The Case for Retirement Income in DC Plans.
Venue: Benefits quarterly
Year: 2016

Myths persist about retirement income solutions in defined contribution (DC) plans. The authors put six common myths to the test: (1) that few plans offer a retirement income option, (2) that retirement is solely a product decision, (3) that retirement income options lack fiduciary clarity, (4) that it's difficult to implement a retirement income option, (5) that retirement income options can be viewed similarly to an asset class and (6) that retirement solutions are too difficult to communicate to participants. They explain why some chatter on the topic of retirement income solutions in DC plans is unfounded.
Metformin alters the gut microbiome of individuals with treatment naive type 2 diabetes, contributing to the therapeutic effects of the drug
Venue: Nature Medicine
Year: 2017

Metformin is widely used in the treatment of type 2 diabetes (T2D) but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin action. In a double blind study, we randomized individuals with treatment naive T2D to placebo or metformin for 4 months and showed that metformin had strong effects on the gut microbiome. These results were verified in a subset of the placebo group that switched to metformin 6 months after the start of the trial. Transfer of fecal samples (obtained before and 4 months after treatment) from metformin treated donors to germ free mice showed that glucose tolerance was improved in mice that received metformin altered microbiota. By directly investigating metformin microbiota interactions in a gut simulator, we showed that metformin affected pathways with common biological functions in species from two different phyla, and many of the metformin regulated genes in these species encoded metalloproteins or metal transporters. Our findings provide support for the notion that altered gut microbiota mediates some of metformin's antidiabetic effects.
Pseudo ternary LiBH4*LiCl*P2S5 system as structurally disordered bulk electrolyte for all solid state lithium batteries.
Venue: Physical chemistry chemical physics PCCP
Year: 2020

The properties of the mixed system LiBH4 LiCl P2S5 are studied with respect to all solid state batteries. The studied material undergoes an amorphization upon heating above 60 degC, accompanied with increased Li+ conductivity beneficial for battery electrolyte applications. The measured ionic conductivity is ~10 3 S cm 1 at room temperature with an activation energy of 0.40(2) eV after amorphization. Structural analysis and characterization of the material suggest that BH4 groups and PS4 may belong to the same molecular structure, where Cl ions interplay to accommodate the structural unit. Thanks to its conductivity, ductility and electrochemical stability (up to 5 V, Au vs. Li+/Li) this new electrolyte is successfully tested in battery cells operated with a cathode material (layered TiS2, theo. capacity 239 mA h g 1) and Li anode resulting in 93% capacity retention (10 cycles) and notable cycling stability under the current density ~12 mA g 1 (0.05C rate) at 50 degC. Further advanced characterisation by means of operando synchrotron X ray diffraction in transmission mode contributes explicitly to a better understanding of the (de)lithiation processes of solid state battery electrodes operated at moderate temperatures.
The Influence of Human Resource Information System (HRIS) Effectiveness on Employees' Performance at Brankas
Year: 2020

Since the 21st century, the use of data makes it possible to assist in making decision and business strategies. Human Resource Information System (HRIS) is an excellent example of utilizing savings in administrative costs and also taking strategies that can benefit companies or organizations by gathering information, processing and sharing. The purpose of this research was to understand the influence of HRIS effectiveness on employees' performance at Brankas. The method used in this research was a quantitative method with data collection technique through the distribution of questionnaires. The type of analysis used is descriptive and causal with the data analysis used descriptive analysis, simple linear regression, determination coefficient, and hypothesis testing. The results of this study showed that HRIS has significant influence on employees' performance at Brankas. The results of this study should be used as input for Brankas through developing and improving the system of HRIS to help the company more efficient in terms of time management by the time set up.
Nucleus Recognition of Uterine Cervical Pap Smears using FCM Clustering Algorithm
Venue: J. Inform. and Commun. Convergence Engineering
Year: 2008

Segmentation for the region of nucleus in the image of uterine cervical cytodiagnosis is known as the most difficult and important part in the automatic cervical cancer recognition system. In this paper, the region of nucleus is extracted from an image of uterine cervical cytodiagnosis using the HSI model. The characteristics of the nucleus are extracted from the analysis of morphemetric features, densitometric features, colormetric features, and textural features based on the detected region of nucleus area. The classification criterion of a nucleus is defined according to the standard categories of the Bethesda system. The fuzzy C means clustering algorithm is employed to the extracted nucleus and the results show that the proposed method is efficient in nucleus recognition and uterine cervical Pap Smears extraction.
Harnessing Difference: A Capability Based Framework for Stakeholder Engagement in Environmental Innovation
Year: 2018

Innovation for environmental sustainability requires firms to engage with external stakeholders to access expertise, solve complex problems, and gain social legitimacy. In this open innovation context, stakeholder engagement is construed as a dynamic capability that can harness differences between external stakeholders to augment their respective resource bases. An integrative systematic review of evidence from 88 scientific articles finds that engaging stakeholders in environmental innovation requires three distinct levels of capability: specific operational capabilities; first order dynamic capabilities to manage the engagement (engagement management capabilities) and second order dynamic capabilities to make use of contrasting ways of seeing the world to reframe problems, combine competencies in new ways, and co create innovative solutions (value framing) and to learn from stakeholder engagement activities (systematized learning) These findings enhance understanding of how firms can effectively incorporate stakeholder perspectives for environmental innovation, and provide an organizing framework for further research into open innovation and co creation more broadly. Wider contributions to the dynamic capabilities literature are to (i) offer a departure point for further research into the relationship between first order and second order dynamic capabilities, (ii) suggest that institutional theory can help explain the dynamic capability of value framing, (iii) build on evidence that inter institutional learning is contingent on not only the similarity but also the differences between organizational value frames, and (iv) suggest that operating capabilities impact the effectiveness of dynamic capabilities, rather than only the other way around, as is usually assumed. A methodological contribution is made through the application of quality assessment criteria scores and intercoder reliability statistics to the selection of articles included in the systematic review.
Artificial Intelligence: The next disrupting technology of Online Marketing
Year: 2019

Lately, notable changes are occurring in the field of online marketing: customers demand ever greater customer experiences when passing through the purchasing journey. Concepts such as hyper personalization, speed, and convenience are gaining enormous attention. With traditional online marketing techniques, businesses are lacking capabilities to tackle these emerging challenges. Advancements in AI marketing applications are now paving the way for businesses to deliver an immersive experience to their customers. Although most business executives acknowledge these developments, a deeper understanding of how exactly AI can facilitate this process is lacking. This knowledge gap is underlined by the identified research gap: there is barely any scientific literature that gives a comprehensive overview of how various AI marketing applications can be used to improve the online customer experience across the entire consumer journey. The objective of this research is to provide such a complete overview. To do so, a literature review is conducted to determine relevant factors of the customer experience and to explore the different stages of the online consumer journey. Next, research papers studying the effects of selected AI marketing applications on the identified factors were reviewed. Lastly, an expert interview was conducted, which provided additional practical insights. This research paper has been finalized with relevant theoretical and managerial implications.
Evaluation of detection probabilities at the water filtering and initial PCR steps in environmental DNA metabarcoding using a multispecies site occupancy model
Venue: Scientific Reports
Year: 2019

Environmental DNA (eDNA) metabarcoding is a recently developed method to assess biodiversity based on a high throughput parallel DNA sequencing applied to DNA present in the ecosystem. Although eDNA metabarcoding enables a rapid assessment of biodiversity, it is prone to species detection errors that may occur at sequential steps in field sampling, laboratory experiments, and bioinformatics. In this study, we illustrate how the error rates in the eDNA metabarcoding based species detection can be accounted for by applying the multispecies occupancy modelling framework. We report a case study with the eDNA sample from an aquarium tank in which the detection probabilities of species in the two major steps of eDNA metabarcoding, filtration and PCR, across a range of PCR annealing temperatures, were examined. We also show that the results can be used to examine the efficiency of species detection under a given experimental design and setting, in terms of the efficiency of species detection, highlighting the usefulness of the multispecies site occupancy modelling framework to study the optimum conditions for molecular experiments.
Endoscopic Papillary Large Balloon Dilation Versus Endoscopic Sphincterotomy for Retrieval of Large Choledocholithiasis: A Prospective Randomized Trial.
Year: 2017

Endoscopic sphincterotomy (ES) is the standard technique for common bile duct (CBD) stone removal. Recently, endoscopic papillary large balloon dilation (EPLBD) has been shown to be a safe and effective technique for the removal of large CBD stone. The aim of this study was to determine the therapeutic outcomes and safety of EPLBD compared with ES for large CBD stone extraction.  One hundred twenty four patients with large bile duct stones were randomized into two groups, the first group included 61 patients subjected to EPLBD and the second group included 63 patients who underwent ES. We compared the success rate of stone removal, frequency of mechanical lithotripsy requirement, morbidity, and mortality.  Baseline characteristics were not significantly different. The overall ductal clearance rate was ultimately similar between the EPLBD group (96.7% and the ES group (93.7% (P .53) the one session ductal clearance rate was significantly different (86.
Building an Inducible T7 RNA Polymerase/T7 Promoter Circuit in Synechocystis sp. PCC6803.
Venue: ACS synthetic biology
Year: 2019

To develop tightly regulated orthogonal gene expression circuits in the photoautotrophic cyanobacterium Synechocystis sp. PCC6803 (Syn6803) we designed a circuit in which a native inducible promoter drives the expression of phage T7 RNA polymerase (T7RNAP) T7RNAP, in turn, specifically recognizes the T7 promoter that is designed to drive GFP expression. In Syn6803, this T7RNAP/T7promoter GFP circuit produces high GFP fluorescence, which was further enhanced by using mutant T7 promoters. We also tested two orthogonal inducible promoters, Trc1O and L03, but these promoters drive T7RNAP to levels that are toxic in E. coli. Introduction of a protein degradation tag alleviated this problem. However, in Syn6803, these circuits did not function successfully. This highlights the underappreciated fact that similar circuits work with varying efficiencies in different chassis organisms. This lays the groundwork for developing new orthogonally controlled phage RNA polymerase dependent expression systems in Syn6803.
A multiobjective optimization model for sustainable reverse logistics in Indian E commerce market
Year: 2020

A cleaner and sustainable environment is becoming a topmost priority for both owners and stakeholders involved in businesses. It could be achieved by adopting better sustainable practices like reduction in waste through process of recycling, recovery and remanufacturing which helps to minimize both the cost and environmental losses. With a recent surge in E commerce market and online shopping in India there is a need for a more efficient, sustainable and reliable reverse logistics design by including cost, environmental and social factors into consideration. With the factors considered above this paper proposes a multi objective logistics network model for the return products specifically pertaining to the Indian E commerce market. The components of this multi echelon supply chain considered are Customer Markets, Warehouses, Delivery Hubs, Landfills, Incineration Centres and Recycling Centres. The multi objective optimization is done on the three fronts of sustainability, namely, economical, represented by cost, environmental, represented by environmental impact of different process, and social, which is represented by work days created and lost due to harms at work. Different technologies are considered in delivery hubs and mother warehouse which could result in a more efficient way of transferring and processing products. Weighted goal programming (WGP) technique is used by weighing different objectives to minimize cost, environment impact and maximize the social responsibility. Finally, model is validated with a numerical example based on an online retail selling clothes. This study will help the managers in deciding the number of facility stores and warehouses needed to open and operate, technology to be adopted for a more efficient way of transferring and processing products.
Impact of the COVID 19 pandemic on hyperacute stroke treatment: experience from a comprehensive stroke centre in Singapore
Venue: Journal of Thrombosis and Thrombolysis
Year: 2020

The Coronavirus disease 2019 (COVID 19) pandemic is rapidly evolving and affecting healthcare systems across the world. Singapore has escalated its alert level to Disease Outbreak Response System Condition (DORSCON) Orange, signifying severe disease with community spread. We aimed to study the overall volume of AIS cases and the delivery of hyperacute stroke services during DORSCON Orange. This was a single centre, observational cohort study performed at a comprehensive stroke centre responsible for AIS cases in the western region of Singapore, as well as providing care for COVID 19 patients. All AIS patients reviewed as an acute stroke activation in the Emergency Department (ED) from November 2019 to April 2020 were included. System processes timings, treatment and clinical outcome variables were collected. We studied 350 AIS activation patients admitted through the ED, 206 (58.9% pre and 144 during DORSCON Orange. Across the study period, number of stroke activations showed significant decline p 0.004, 95% CI 6.513 to 2.287) as the number of COVID 19 cases increased exponentially, whilst proportion of activations receiving acute recanalization therapy remained stable p 0.519, 95% CI 1.605 to 2.702) Amongst AIS patients that received acute recanalization therapy, early neurological outcomes in terms of change in median NIHSS at 24 h 4 versus 4, p 0.685) were largely similar between the pre and during DORSCON orange periods. The number of stroke activations decreased while the proportion receiving acute recanalization therapy remained stable in the current COVID 19 pandemic in Singapore.
[Biological function and molecular mechanism of URI in HepG2 cells]
Venue: Zhonghua zhong liu za zhi [Chinese journal of oncology]
Year: 2014

To explore the effect and molecular mechanism of the unconventional prefoldin RPB5 interactor (URI) in hepatocellular carcinoma HepG2 cells.  The cDNA sequence and shRNA of URI were obtained and sub cloned into eukaryotic expression vectors. Then those vectors were transfected into HepG2 cells to obtain stable transfection cell line. The cell proliferation and anchor independent growth in URI overexpressing and knockdown HepG2 cells were determined by CCK 8 and soft agar colony assay. Flow cytometry was applied to detect the cell cycle and apoptosis of g ray irradiated cells. Apoptosis related genes were detected by Western blot.  The pCDNA3.1 URI and pGPU6 URIi eukaryotic expression vectors were constructed successfully and corresponding stable transfection cell lines were obtained. Cell proliferation rates of the HepG2, pCDNA3.1 URI HepG2 and pGPU6 URIi HepG2 cells were (588.78 32.12) (959.33 58.8) and (393.93 39.7) respectively (P 0.05) The number of cell clones of HepG2, pCDNA3.1 URI HepG2 and pGPU6 URIi HepG2 cells were 43 7, 85 5 and 20 4 (P 0.05) respectively. After g ray irradiation, the URI overexpressing cell line showed a significantly lower apoptosis rate and G(2)/M phase arrest than those in the URI depleted cell line (P 0.05) In the HepG2 cells, the relative protein expression levels of URI, Bax and Bcl 2 were 0.92 0.03, 1.11 0.13 and 0.82 0.01 (P 0.05) In the pCDNA3.1 URI HepG2 cells, the relative protein expression levels of URI, Bax and Bcl 2 were 1.79 0.12, 0.48 0.01 and 2.20 0.30 (P 0.05) respectively. In the pGPU6 URIi HepG2 cells, the relative protein expression levels of URI, Bax and Bcl 2 were 0.50 0.04, 1.52 0.20 and 0.38 0.01 (P 0.05) respectively. The expression of Bax was down regulated and Bcl 2 was up regulated in the URI overexpressing cell line. However, on the contrary, expression of Bax was up regulated and Bcl 2 was down regulated in the URI depleted cell line.  URI may promote the growth of hepatocellular carcinoma cells via inhibition of cell proliferation and reducing the apoptosis in hepatocellular carcinoma cells in vitro. After the impairment of URI expression, the proliferation ability of hepatocellular carcinoma cells is suppressed and the ability to resist g ray irradiation is reduced. URI may become a potential new target for cancer therapy of hepatocellular carcinoma.
Design and Implementation of intelligent Learning Companion System Based on WeChat Mini Program
Venue: 2020 International Conference on Artificial Intelligence and Education (ICAIE)
Year: 2020

During the period of COVID 19 epidemic situation, in order to ensure that students can study normally, the Ministry of Education has issued measures to "suspend classes without stopping learning" Therefore, the traditional forms can't meet the needs of learners, more and more people like online education. The existing online learning platforms cannot perfectly meet the learning needs of students, so the students need an online learning system that can meet their individual needs and improve learning efficiency. This article introduces an intelligent learning companion system, the system based on the advantages of WeChat Mini Programs can help learners achieve online learning and meet personalized needs.
Free Education: Pro and Contra
Year: 2014

The humanistic paradigm of free education as a form of manifestation of universal moral values is a historical and cultural phenomenon in the philosophy of education and at the same time a contradictory phenomenon of education at the moment. The theory of free education being objectively considered a historical and cultural component of the basic humanistic tradition of education is in close connection with the problems handled by the pedagogy of freedom. In teaching there is still no clear attitude to free education, to its pros and cons. That's why we can observe a permanent debate in the modern formulation of this aspect. Moreover, the concept of "free education" has no exact definition. The article generalizes key points and discloses "pro and contra" of free education.