nils-herrmann/clean_scirepeval huggingface dataset:
Olaparib for Metastatic Castration Resistant Prostate Cancer.
Venue: The New England journal of medicine
Year: 2020

Multiple loss of function alterations in genes that are involved in DNA repair, including homologous recombination repair, are associated with response to poly(adenosine diphosphate ribose) polymerase (PARP) inhibition in patients with prostate and other cancers.  We conducted a randomized, open label, phase 3 trial evaluating the PARP inhibitor olaparib in men with metastatic castration resistant prostate cancer who had disease progression while receiving a new hormonal agent (e.g. enzalutamide or abiraterone) All the men had a qualifying alteration in prespecified genes with a direct or indirect role in homologous recombination repair.  A (245 patients) had at least one alteration in BRCA1, BRCA2, or ATM; cohort B (142 patients) had alterations in any of 12 other prespecified genes, prospectively and centrally determined from tumor tissue. Patients were randomly assigned (in a 2:1 ratio) to receive olaparib or the physician's choice of enzalutamide or abiraterone (control) The primary end point was imaging based progression free survival in cohort A according to blinded independent central review.  In cohort A, imaging based progression free survival was significantly longer in the olaparib group than in the control group (median, 7.4 months vs. 3.6 months; hazard ratio for progression or death, 0.34; 95% confidence interval, 0.25 to 0.47; P<0.001) a significant benefit was also observed with respect to the confirmed objective response rate and the time to pain progression. The median overall survival in cohort A was 18.5 months in the olaparib group and 15.1 months in the control group; 81% of the patients in the control group who had progression crossed over to receive olaparib. A significant benefit for olaparib was also seen for imaging based progression free survival in the overall population (cohorts A and B) Anemia and nausea were the main toxic effects in patients who received olaparib.  In men with metastatic castration resistant prostate cancer who had disease progression while receiving enzalutamide or abiraterone and who had alterations in genes with a role in homologous recombination repair, olaparib was associated with longer progression free survival and better measures of response and patient reported end points than either enzalutamide or abiraterone. (Funded by AstraZeneca and Merck Sharp Dohme; PROfound ClinicalTrials.gov number, NCT02987543.
El impacto de propuestas educativas mediadas por TIC en la retencion estudiantil. Un estudio de caso de los estudiantes de Ingenieria de la Universidad Nacional del Noroeste de la Provincia de Buenos Aires
Year: 2020

Resena de la tesis presentada por la autora el 16 de julio de 2020 para la obtencion del titulo de Magister en Tecnologia Informatica Aplicada en Educacion en la UNLP.
Estimation of tire road friction coefficient and frictional force for Active Vehicle safety system
Venue: 2015 International Conference on Industrial Instrumentation and Control (ICIC)
Year: 2015

An increasing number of accidents of Vehicles has led to the study and design of Active safety systems in modern automobiles. For the purpose, a number of sensors for the measurement of Vehicle yaw, wheel velocities and acceleration are deployed. However, some key parameters like slip angle and frictional forces are hard to be determined using sensors and also cost prohibitive. Estimation of friction coefficient and frictional forces has been of wide importance for the design of Active safety systems as the information is required for the design of efficient control system. Besides, the system being highly nonlinear in nature, linearized estimation technique may lead to high approximation errors. This paper presents an unscented Kalman Filter based estimation algorithm for a specific nonlinear tire model for the estimation of friction coefficient and lateral and longitudinal frictional forces.
A survey on video compression fast block matching algorithms
Venue: Neurocomputing
Year: 2019

Video compression is the process of reducing the amount of data required to represent digital video while preserving an acceptable video quality. Recent studies on video compression have focused on multimedia transmission, videophones, teleconferencing, high definition television, CD ROM storage, etc. The idea of compression techniques is to remove the redundant information that exists in the video sequences. Motion compensation predictive coding is the main coding tool for removing temporal redundancy of video sequences and it typically accounts for 50 80% of video encoding complexity. This technique has been adopted by all of the existing International Video Coding Standards. It assumes that the current frame can be locally modelled as a translation of the reference frames. The practical and widely method used to carry out motion compensated prediction is block matching algorithm. In this method, video frames are divided into a set of non overlapped macroblocks and compared with the search area in the reference frame in order to find the best matching macroblock. This will carry out displacement vectors that stipulate the movement of the macroblocks from one location to another in the reference frame. Checking all these locations is called Full Search, which provides the best result. However, this algorithm suffers from long computational time, which necessitates improvement. Several methods of Fast Block Matching algorithm are developed to reduce the computation complexity. This paper focuses on a survey for two video compression techniques: the first is called the lossless block matching algorithm process, in which the computational time required to determine the matching macroblock of the Full Search is decreased while the resolution of the predicted frames is the same as for the Full Search. The second is called lossy block matching algorithm process, which reduces the computational complexity effectively but the search result's quality is not the same as for the Full Search.
Large Scale Diversity of Slope Fishes: Pattern Inconsistency between Multiple Diversity Indices
Venue: PloS one
Year: 2013

Large scale studies focused on the diversity of continental slope ecosystems are still rare, usually restricted to a limited number of diversity indices and mainly based on the empirical comparison of heterogeneous local data sets. In contrast, we investigate large scale fish diversity on the basis of multiple diversity indices and using 1454 standardized trawl hauls collected throughout the upper and middle slope of the whole northern Mediterranean Sea (36deg3' 45deg7' N; 5deg3'W 28degE) We have analyzed (1) the empirical relationships between a set of 11 diversity indices in order to assess their degree of complementarity/redundancy and (2) the consistency of spatial patterns exhibited by each of the complementary groups of indices. Regarding species richness, our results contrasted both the traditional view based on the hump shaped theory for bathymetric pattern and the commonly admitted hypothesis of a large scale decreasing trend correlated with a similar gradient of primary production in the Mediterranean Sea. More generally, we found that the components of slope fish diversity we analyzed did not always show a consistent pattern of distribution according either to depth or to spatial areas, suggesting that they are not driven by the same factors. These results, which stress the need to extend the number of indices traditionally considered in diversity monitoring networks, could provide a basis for rethinking not only the methodological approach used in monitoring systems, but also the definition of priority zones for protection. Finally, our results call into question the feasibility of properly investigating large scale diversity patterns using a widespread approach in ecology, which is based on the compilation of pre existing heterogeneous and disparate data sets, in particular when focusing on indices that are very sensitive to sampling design standardization, such as species richness.
A broadband high efficiency rectifier for ambient RF energy harvesting
Venue: 2014 IEEE MTT S International Microwave Symposium (IMS2014)
Year: 2014

Ambient energy harvesting is a key technology to the success of wireless sensor networks. Among various energy sources available in daily environment, electromagnetic RF energy is a good source due to the wide signal coverage from various wireless communication systems. Harvesting a wide frequency band RF signals is useful to boost the total energy level. In this paper, a broadband high efficiency RF rectifier with a shunted Schottky diode is presented. The source pull simulation is used to find the optimal source impedance over the wide frequency range while maintaining good conversion efficiency. A 3rd transmission line low pass matching network is designed to realize the optimal source impedance. The measurement results agree well with the simulation results. The highest measured efficiency is 81% and a frequency band 0.78 1.43 GHz with efficiency exceeding 50% is achieved for an input power level of 25 mW.
Social cognitive neuroscience and humanoid robotics
Venue: Journal of Physiology Paris
Year: 2009

We believe that humanoid robots provide new tools to investigate human social cognition, the processes underlying everyday interactions between individuals. Resonance is an emerging framework to understand social interactions that is based on the finding that cognitive processes involved when experiencing a mental state and when perceiving another individual experiencing the same mental state overlap, both at the behavioral and neural levels. We will first review important aspects of his framework. In a second part, we will discuss how this framework is used to address questions pertaining to artificial agents' social competence. We will focus on two types of paradigm, one derived from experimental psychology and the other using neuroimaging, that have been used to investigate humans' responses to humanoid robots. Finally, we will speculate on the consequences of resonance in natural social interactions if humanoid robots are to become integral part of our societies.
Identification of PSEN2 mutation p.N141I in Argentine pedigrees with early onset familial Alzheimer's disease
Venue: Neurobiology of Aging
Year: 2015

Presenilin 2 gene (PSEN2) mutations account for <5% of all early onset familial Alzheimer's disease (EOFAD) cases and only 13 have strong evidence for pathogenicity. We aimed to investigate the presence of PSEN2 mutation p.N141I and characterize the clinical phenotypes in 2 Argentine pedigrees (AR2 and AR3) with clinical symptoms of EOFAD. Detailed clinical assessments and genetic screening for PSEN2 and APOE genes were carried out in 19 individuals of AR2 and AR3 families. The p.N141I mutation was identified in all affected subjects and was associated with prominent early onset, rapidly progressive dementia, neurologic, and behavioral symptoms. AR2 and AR3 families share the same Volga German ancestry as all the families reported presenting this mutation. To our knowledge, this is the first report of PSEN2 mutation p.N141I in Argentina and even more, in South America. Our contribution increases the total number of described families carrying this mutation and help to improve the characterization of clinical phenotype in EOFAD associated to PSEN2 mutations.
Diagnosis, treatment, and prevention of gout.
Venue: American family physician
Year: 2014

Gout is characterized by painful joint inflammation, most commonly in the first metatarsophalangeal joint, resulting from precipitation of monosodium urate crystals in a joint space. Gout is typically diagnosed using clinical criteria from the American College of Rheumatology. Diagnosis may be confirmed by identification of monosodium urate crystals in synovial fluid of the affected joint. Acute gout may be treated with nonsteroidal anti inflammatory drugs, corticosteroids, or colchicine. To reduce the likelihood of recurrent flares, patients should limit their consumption of certain purine rich foods (e.g. organ meats, shellfish) and avoid alcoholic drinks (especially beer) and beverages sweetened with high fructose corn syrup. Consumption of vegetables and low fat or nonfat dairy products should be encouraged. The use of loop and thiazide diuretics can increase uric acid levels, whereas the use of the angiotensin receptor blocker losartan increases urinary excretion of uric acid. Reduction of uric acid levels is key to avoiding gout flares. Allopurinol and febuxostat are first line medications for the prevention of recurrent gout, and colchicine and/or probenecid are reserved for patients who cannot tolerate first line agents or in whom first line agents are ineffective. Patients receiving urate lowering medications should be treated concurrently with nonsteroidal anti inflammatory drugs, colchicine, or low dose corticosteroids to prevent flares. Treatment should continue for at least three months after uric acid levels fall below the target goal in those without tophi, and for six months in those with a history of tophi.
GENDER IN EFL CLASSROOM: TRANSITIVITY ANALYSIS IN ENGLISH TEXTBOOK FOR INDONESIAN STUDENTS
Year: 2017

This paper is concerned with the topic of gender in EFL classroom, particularly in Indonesian context. Owing to the framework proposed by Sunderland (1992) the paper focuses on the discussion of gender in classroom materials, i.e. English textbooks. Selected reading passages were analyzed within the framework of Transitivity system of functional grammar (Halliday Mathiessen, 2004; Haliday Mathiessen, 2014) The Processes in the texts (e.g. travel, walk, and climb) reveal that males were perpetually constructed as 'adventurous' 'risk taker' 'active' 'independent' and 'capable' Meanwhile, the Processes also indicate that the females were shaped as more 'passive' 'expressive' 'nurturing' and 'unassertive' than their male counterparts (Blackstone, 2003; Evans Davies, 2000) The findings suggest that the gender roles were presented in an asymmetrical manner. The paper provides recommendation in terms of how both teachers and students can develop gender awareness in the classroom practices through the use of the textbooks.
Phonemic awareness in Dutch kindergartners: Effects of task, phoneme position, and phoneme class
Year: 2011

The aim of the present study was to provide more insight in the relative difficulty of four tasks testing phonemic awareness: (a) blending, (b) isolation, (c) segmentation, and (d) deletion. At the same time the roles of phoneme position and phoneme class were taken into account in a fully balanced way. To this purpose, 141 kindergartners were presented with four phonemic manipulation tasks consisting of the same 32 CVC items. Children performed better on phoneme blending and phoneme isolation compared to phoneme segmentation and phoneme deletion. However, performance between and within phoneme tasks appeared also to be dependent on phoneme position. Phoneme class exerted effects within the initial and final position of the four different tasks. The effect of plosives and fricatives compared to that of nasals and liquids on performance was particularly striking. Our findings were explained in terms of sonority and degree of co articulation in pre vocalic and post vocalic plosives.
In Vitro Tensile Strength Study on Suturing Technique and Material
Venue: The Journal of oral implantology
Year: 2017

&NA; Suture technique and materials are important in preventing complications such as wound dehiscences. The purpose of this study was to determine the tensile strength of different suturing techniques, comparing several materials with different diameters. One hundred sixty sutures were performed using silk, e PTFE, and 2 types of polyamide (monofilament and Supramid) Ten simple, 10 horizontal mattress, and 10 combinations of the two stitches were performed with 4 0 gauge of each material. Additionally, 10 simple sutures were performed with the 5 0 gauge of each material. The maximum tensile force resisted by each suture was recorded. When 5 mm of traction was applied, the polyamide monofilament resisted significantly better without untying or breaking compared with Supramid or silk, while the e PTFE was superior to all the others. However, the force when e PTFE 4 0 sutures untied or broke was lower than for either type of polyamide. The combined technique withstood a significantly higher tensile force before unknotting or breaking than did the simple and mattress stitches. The 5 0 gauges of silk and both types of polyamide showed lower tensile strengths than the 4 0 materials. Among the 5 0 sutures, Supramid showed a higher tensile strength than silk. The combined suture technique possessed greater tensile strength than did a simple or a horizontal mattress suture, and e PTFE 4 0 withstood more traction without untying or breaking than did all the other materials, although at a lower tensile force. With the exception of e PTFE, 4 0 sutures had greater tensile strength than did 5 0 sutures.
Controllable cross speaker emotion transfer for end to end speech synthesis
Venue: ArXiv
Year: 2021

The cross speaker emotion transfer task in text tospeech (TTS) synthesis particularly aims to synthesize speech for a target speaker with the emotion transferred from reference speech recorded by another (source) speaker. During the emotion transfer process, the identity information of the source speaker could also affect the synthesized results, resulting in the issue of speaker leakage, i.e. synthetic speech may have the voice identity of the source speaker rather than the target speaker. This paper proposes a new method with the aim to synthesize controllable emotional expressive speech and meanwhile maintain the target speaker's identity in the cross speaker emotion TTS task. The proposed method is a Tacotron2 based framework with the emotion embedding as the conditioning variable to provide emotion information. Two emotion disentangling modules are contained in our method to 1) get speaker independent and emotion discriminative embedding, and 2) explicitly constrain the emotion and speaker identity of synthetic speech to be that as expected. Moreover, we present an intuitive method to control the emotional strength in the synthetic speech for the target speaker. Specifically, the learned emotion embedding is adjusted with a flexible scalar value, which allows controlling the emotion strength conveyed by the embedding. Extensive experiments have been conducted on a Mandarin disjoint corpus, and the results demonstrate that the proposed method is able to synthesize reasonable emotional speech for the target speaker. Compared to the state of the art reference embedding learned methods, our method gets the best performance on the cross speaker emotion transfer task, indicating that our method achieves the new state of the art performance on learning the speaker independent emotion embedding. Furthermore, the strength ranking test and pitch trajectories plots demonstrate that the proposed method can effectively control the emotion strength, leading to prosodydiverse synthetic speech.
Exploring Connected Dominating Sets in Energy Harvest Networks
Venue: IEEE/ACM Transactions on Networking
Year: 2017

Duty cycle scheduling is an effective way to balance energy consumptions and prolong network lifetime of wireless sensor networks (WSNs) which usually requires a connected dominating set (CDS) to guarantee network connectivity and coverage. Therefore, the problem of finding the largest number of CDSs is important for WSNs. The previous works always assume all the nodes are non rechargeable. However, WSNs are now taking advantages of rechargeable nodes to become energy harvest networks (EHNs) To find the largest number of CDSs then becomes completely different. This is the first work to investigate, how to identify the largest number of CDSs in EHNs to prolong network lifetime. The investigated novel problems are proved to be NP Complete and we propose four approximate algorithms, accordingly. Both the solid theoretical analysis and the extensive simulations are performed to evaluate our algorithms.
Implanting Big Data Technology into the Construction of "Smart Parking"
Venue: 2020 17th International Computer Conference on Wavelet Active Media Technology and Information Processing (ICCWAMTIP)
Year: 2020

As my country attaches more and more importance to the construction of smart cities, the construction of smart parking is gradually becoming more mature. With the advent of the big data era, data analysis is becoming more and more important in the construction of smart parking. Big data analysis can not only effectively use idle data, but also provide government managers with effective, accurate, and real time data support, thereby improving the efficiency of managers' planning and management of parking lots. This paper mainly studies the current complex parking situation in Tongliang District of Chongqing City, and uses big data technology to replace traditional data management methods to solve the current problems of parking business in Tongliang District, Chongqing City.
Diversity and biological activities of endophytic fungi associated with Catharanthus roseus
Venue: BMC Microbiology
Year: 2019

BackgroundThe present study involves diversity and bioactivity of the endophytic fungal community from Catharanthus roseus inhabiting the coastal region. This study has been conducted hypothesizing that the microbial communities in the coastal regions would tolerate a range of abiotic stress such as salinity, humidity, temperature and soil composition, and it may produce new metabolites, which may possess bioactive property. Therefore in the current study, the cytotoxicity and free radical scavenging potential of the fungal organic extracts have been investigated. Moreover, the apoptotic and the antioxidant potential of the fungus that exhibited the best activity in preliminary screening has also been demonstrated.ResultsTwenty endophytic fungal isolates were obtained from different parts of the plant, and identified using internal transcribed spacer region analysis. Based on the colonization frequency, the dominant genera were found to be Colletotrichum, Alternaria and Chaetomium with colonization frequency of 8.66, 7.00 and 6.33, respectively. It was observed that the species diversity and richness was the highest in bark followed by leaf and stem regions of the plant. On screening the fungal ethyl acetate extracts for cytotoxicity against the HeLa cells, the Chaetomium nigricolor extract exhibited potent cytotoxic activity of 92.20% at 100 mg mL 1 concentration. Comparison between the different organic extracts (ethyl acetate, chloroform, dichloromethane and hexane) of Chaetomium nigricolor mycelial and culture filtrate, it was observed that the mycelial as well the culture filtrate ethyl acetate extracts and the culture filtrate hexane extract showed significant cytotoxic potential against the HeLa and MCF 7 cells, respectively. The apoptotic and mitochondrial membrane depolarisation induction potential of the Chaetomium nigricolor ethyl acetate extract has also been demonstrated in this study. Further the screening of antioxidant potential of the ethyl acetate fungal extracts using DPPH scavenging assay showed that Chaetomium nigricolor extract exhibited potential activity with a significant EC50 value of 22 mg mL 1. The ethyl acetate extract of Chaetomium nigricolor also exhibited superoxide radical scavenging potential.ConclusionThese results indicated that diverse endophytic fungal population inhabits Catharanthus roseus. One of the fungal isolate Chaetomium nigricolor exhibited significant cytotoxic, apoptotic and antioxidant potential.