nils-herrmann/clean_scirepeval huggingface dataset:
Evaluation of Immune Related Response Criteria and RECIST v1.1 in Patients With Advanced Melanoma Treated With Pembrolizumab.
Venue: Journal of clinical oncology official journal of the American Society of Clinical Oncology
Year: 2016

We evaluated atypical response patterns and the relationship between overall survival and best overall response measured per immune related response criteria (irRC) and Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1) in patients with advanced melanoma treated with pembrolizumab in the phase Ib KEYNOTE 001 study (clinical trial information: NCT01295827)  Patients received pembrolizumab 2 or 10 mg/kg every 2 weeks or every 3 weeks. Atypical responses were identified by using centrally assessed irRC data in patients with 28 weeks of imaging. Pseudoprogression was defined as 25% increase in tumor burden at week 12 (early) or any assessment after week 12 (delayed) that was not confirmed as progressive disease at next assessment. Response was assessed centrally per irRC and RECIST v1.1.  Of the 655 patients with melanoma enrolled, 327 had 28 weeks of imaging follow up. Twenty four (7% of these 327 patients had atypical responses (15 [5% with early pseudoprogression and nine [3% with delayed pseudoprogression) Of the 592 patients who survived 12 weeks, 84 (14% experienced progressive disease per RECIST v1.1 but nonprogressive disease per irRC. Two year overall survival rates were 77.6% in patients with nonprogressive disease per both criteria (n 331) 37.5% in patients with progressive disease per RECIST v1.1 but nonprogressive disease per irRC (n 84) and 17.3% in patients with progressive disease per both criteria (n 177)  Atypical responses were observed in patients with melanoma treated with pembrolizumab. Based on survival analysis, conventional RECIST might underestimate the benefit of pembrolizumab in approximately 15% of patients; modified criteria that permit treatment beyond initial progression per RECIST v1.1 might prevent premature cessation of treatment.
Research on the Construction of Litchi Farmers Marketing Channels Based on Trust
Year: 2010

Channel is the new concept of modern marketing.A sample survey about the litchi farmers living in Bai Qiao Village,Genzi town,Gaozhou City,Guangdong Province finds that the key factor leads to litchi output increase without profit increase is the channel for a single,loose organization,frequent conflict and lack of mutual trusted communication platform,etc.To build a trust based litchi farmer marketing channel,we should strengthen the education of litchi farmers,innovate planting patterns,increase relationship specific assets investment,and build information exchange platform.
DEVELOPMENT AND VALIDATION OF THE SEXUAL ABSTINENCE SCALE (SAS)
Year: 2014

The Sexual Abstinence Scale (SAS) is designed to assess healthy sexual behaviour among adolescents as a way to reduce the incidence of HIV and other sexually transmitted diseases. This cross sectional study took place in two phases. The first phase comprised of 1030 adolescents randomly selected from senior classes in secondary schools in three out of five local government areas within Ibadan municipality. The second phase had 250 participants also randomly selected from senior secondary classes. items generated for the scale were obtained from an extensive literature review. The content validity of the instrument was confirmed through peer reviews of experts in the field of adolescent sexuality. The internal consistencies for the six sub scales were .8430 for knowledge of sexual abstinence sub scale, .8170 for perceived risk of sexual abstinence sub scale, .6310 for attitude towards sexual abstinence sub scale, .9380 for perceived benefits of sexual abstinence sub scale,.7910 for sexual abstinence self efficacy sub scale, .8030 sexual abstinence education sub scale and .8860 for the full scale. The relevance of this scale to stakeholders in adolescent's reproductive health behaviour, counsellors, researchers as well as the limitations are discussed.
Effectiveness of a Web Based Simulation in Improving Nurses' Workplace Practice With Deteriorating Ward Patients: A Pre and Postintervention Study
Venue: Journal of medical Internet research
Year: 2016

Nurses play an important role in detecting patients with clinical deterioration. However, the problem of nurses failing to trigger deteriorating ward patients still persists despite the implementation of a patient safety initiative, the Rapid Response System. A Web based simulation was developed to enhance nurses' role in recognizing and responding to deteriorating patients. While studies have evaluated the effectiveness of the Web based simulation on nurses' clinical performance in a simulated environment, no study has examined its impact on nurses' actual practice in the clinical setting.  The objective of this study was to evaluate the impact of Web based simulation on nurses' recognition of and response to deteriorating patients in clinical settings. The outcomes were measured across all levels of Kirkpatrick's 4 level evaluation model with clinical outcome on triggering rates of deteriorating patients as the primary outcome measure.  A before and after study was conducted on two general wards at an acute care tertiary hospital over a 14 month period. All nurses from the two study wards who undertook the Web based simulation as part of their continuing nursing education were invited to complete questionnaires at various time points to measure their motivational reaction, knowledge, and perceived transfer of learning. Clinical records on cases triggered by ward nurses from the two study wards were evaluated for frequency and types of triggers over a period of 6 months pre and 6 months postintervention.  The number of deteriorating patients triggered by ward nurses in a medical general ward increased significantly (P<.001) from pre (84/937, 8.96% to postintervention (91/624, 14.58% The nurses reported positively on the transfer of learning (mean 3.89, SD 0.49) from the Web based simulation to clinical practice. A significant increase (P<.001) on knowledge posttest score from pretest score was also reported. The nurses also perceived positively their motivation (mean 3.78, SD 0.56) to engage in the Web based simulation.  This study provides evidence on the effectiveness of Web based simulation in improving nursing practice when recognizing and responding to deteriorating patients. This educational tool could be implemented by nurse educators worldwide to address the educational needs of a large group of hospital nurses responsible for patients in clinical deterioration.
Percepcion de comportamientos de riesgo en estudiantes universitarios del area de la salud
Year: 2015

espanolLos estilos de vida de algunos jovenes los situan en circunstancias de riesgos de salud. Por ello, el objetivo de este trabajo es describir comportamientos de riesgo percibidos en universitarios del area de la salud. Se aplico una encuesta de 14 items sobre la practica de actividad fisica, alimentacion, consumo de drogas, nivel de estres y habitos de sueno a jovenes del area de la salud. Se encuestaron 995 alumnos. La mayoria mujeres (69% edad de 20.1 1.8 anos, 29% reporta no hacer ejercicio y 51% consume cinco frutas y verduras cuatro veces/ semana o mas. Solo el 30% consume dos litros de agua/dia, 82% no fuma, 55% no consume bebidas alcoholicas y 90% no consume drogas. El 12% reporta estar estresado siempre y 72% duerme mas de siete horas diarias solo tres veces/semana o menos. Se concluye que los universitarios del area de la salud encuestados no cumplen con un estilo de vida saludable. EnglishRisk behaviors associated with life style may deliver in students' health risk. Therefore, our objective is to describe health risk behaviors perceived by health area university students. For this a 14 item survey about risk behaviors related to physical activity practice, food consumption, drug use, stress level and sleep habits was applied in the health area students. 995 students were interviewed. Most were women (69% with 20.1 1.8 years old. Of these women surveyed, twenty nine percent report no physical activity. Fifty one percent eat 5 fruit and vegetables 4 times/week or more. Only 30% drinks 2 L of water/day. Eighty two percent don't smoke, 55% don't drink alcohol and 90% don't use drugs. Twelve percent reports to be on stress always and 72% sleep more than 7 hours/day only 3 times/week or less. This work concluded that university students of the Health Area don't have the healthy life style that's expected.
Fairness aware Outlier Ensemble
Venue: ArXiv
Year: 2021

Outlier ensemble methods have shown outstanding performance on the discovery of instances that are significantly different from the majority of the data. However, without the awareness of fairness, their applicability in the ethical scenarios, such as fraud detection and judiciary judgement system, could be degraded. In this paper, we propose to reduce the bias of the outlier ensemble results through a fairness aware ensemble framework. Due to the lack of ground truth in the outlier detection task, the key challenge is how to mitigate the degradation in the detection performance with the improvement of fairness. To address this challenge, we define a distance measure based on the output of conventional outlier ensemble techniques to estimate the possible cost associated with detection performance degradation. Meanwhile, we propose a post processing framework to tune the original ensemble results through a stacking process so that we can achieve a trade off between fairness and detection performance. Detection performance is measured by the area under ROC curve (AUC) while fairness is measured at both group and individual level. Experiments on eight public datasets are conducted. Results demonstrate the effectiveness of the proposed framework in improving fairness of outlier ensemble results. We also analyze the trade off between AUC and fairness.
Neo marketing (Reloaded)
Year: 2009

Cette reedition enrichie fait le point sur les evolutions du marketing depuis les annees 1990.Lors de sa premiere edition, en 1992, Neo Marketing apparut comme un manifeste impertinent invitant a une discussion serieuse des presupposes et des pratiques tant professionnelles qu'academiques du Marketing. En s'appuyant sur le courant postmoderne et sur l'ecole italienne de sociologie, nous y proposions une relecture de la societe de consommation et des pratiques de consommation et d'achat et suggerions une refonte des appareils theoriques et pratiques du marketing (allant meme jusqu'a remettre en cause des dogmes aussi forts que le besoin d'interroger les consommateurs).Cette reedition enrichie d'une longue postface permet de se replonger dans un texte qui semble encore fort utile, tant pour lire les evolutions de la societe occidentale, de la consommation et du marketing, que pour explorer les fondements et les raisons de courants de recherche tres contemporains comme la Consumer Culture Theory et autres nouvelles pratiques du marketing (ethnomarketing, marketing tribal, buzzmarketing, empowerement marketing, de marketing, co valueing, spiritual offering, etc. Ce Neo Marketing enrichi esquisse les bases d'un marketing a la fois moins mecaniste et plus ,emotionnel, a la fois moins cynique et plus humaniste le Societing.
Hydrodeoxygenation of anisole as bio oil model compound over supported Ni and Co catalysts: Effect of metal and support properties
Year: 2015

Hydrodeoxygenation (HDO) is considered one of the most promising routes to convert the pyrolysis bio oils produced from lignocellulose into biofuels very similar to those derived from petroleum. This work reports results obtained in the catalytic HDO of anisole over non conventional hydrotreating catalysts based on metallic Ni and Co supported on micro mesoporous carriers of different acidity. Anisole has been chosen as representative of those compounds, containing a methoxy phenyl group, which are abundant in lignocellulose pyrolysis bio oils. The effect of both metal phase and support properties on their performance as HDO catalysts has been studied. With this aim, three supports with different textural and acidic properties have been employed: hierarchical ZSM 5, mesostructured pure silica SBA 15 and mesostructured Al SBA 15. The reactions have been carried out in a stainless steel high pressure batch reactor at 220 degC and with 50 bar of pure hydrogen. The interaction of the metallic species (Ni or Co) with the porous supports, as well as their dispersion, is strongly affected by the support nature and the presence of Al. Thus, it has been found a synergetic effect between the acid sites of the supports and the metallic active phases, which favors and enhances the HDO of anisole. In the case of the acidic supports, Ni based catalysts (Ni/Al SBA 15 and Ni/h ZSM 5) show larger anisole conversions compared to Co based materials. The strong interaction with the acidic supports of the latter hinders the total Co reduction prior to the reaction, being probably the major reason of their lower activity. Hydrodeoxygenation, hydrodearomatization and isomerization reactions take place extensively over Ni/h ZSM 5, revealing it is a promising catalyst for bio oil processing in order to attain high quality fuel production.
An IoT Smart Infrastructure for S. Domenico Church in Matera's "Sassi' A Multiscale Perspective to Built Heritage Conservation
Year: 2020

Architectural heritage is perhaps the most important marker of the Italian and European landscapes. Over the last decades, its strategic relevance for local economic development has led to prioritize tourism oriented promotion objectives. Therefore, new light has been thrown on once unknown resources that have thus received the attention of tourists interested in new visit experiences. To this end, Information and Communication Technologies (ICTs) have delivered a crucial support mainly in terms of public attraction and creation of new cultural offers. However, new urgent challenges now face tangible heritage, whose physical existence is jeopardized through extreme events and poor maintenance. Unexpected intense visit flows represent in themselves a further threat for sensitive heritages. ICTs have then to cope with more complex conservation tasks and the Internet of Things (IoT) can facilitate appropriate solutions. The paper presents a smart sensor based infrastructure for the structural monitoring of S. Domenico Church in Matera, an emblematic city for the concerns described, which also highlighted the need for a wider conservation concept also embracing context and fruition issues. The article introduces the case study and its delicate environment, and the technological background of heritage monitoring solutions; the proposed IoT infrastructure is then described, discussing its potentialities and IoT contribution to creating more holistic and multiscale perspectives to heritage conservation.
In Shoe Plantar Pressure Measurement Influence of Insole Placement on Selected Parameters during Running
Year: 2020

While it is assumed that pressure sensing insoles are usually placed directly below the foot and on top of the shoes' standard insoles, nearly no previously published study actually describes the procedure, which leaves a slight uncertainty. Therefore, the aim of this study was to evaluate whether the placement has an influence on selected parameters or not. Five healthy participants took part in the measurements and ran on a treadmill at a running velocity of 10 km/h with three different running shoes. Plantar pressure was measured using pressure sensing insoles, which were once placed on top and once below the shoes' standard insoles. Selected parameters were the maximum and mean pressure and the range of the center of pressure (COP) in anterior posterior and medial lateral directions. The results indicate that maximum and mean pressure decrease when the pressure sensing insole lies below the shoe's insole and the medial lateral COP is the least effected parameter.
Herbivory responsive calmodulin like protein CML9 does not guide jasmonate mediated defenses in Arabidopsis thaliana
Venue: PloS one
Year: 2018

Calcium is an important second messenger in plants that is released into the cytosol early after recognition of various environmental stimuli. Decoding of such calcium signals by calcium sensors is the key for the plant to react appropriately to each stimulus. Several members of Calmodulin like proteins (CMLs) act as calcium sensors and some are known to mediate both abiotic and biotic stress responses. Here, we study the role of the Arabidopsis thaliana CML9 in different stress responses. CML9 was reported earlier as defense regulator against Pseudomonas syringae. In contrast to salicylic acid mediated defense against biotrophic pathogens such as P. syringae, defenses against herbivores and necrotrophic fungi are mediated by jasmonates. We demonstrate that CML9 is induced upon wounding and feeding of the insect herbivore Spodoptera littoralis. However, neither different CML9 loss of function mutant lines nor overexpression lines were impaired upon insect feeding. No difference in herbivore induced phytohormone elevation was detected in cml9 lines. The defense against the spider mite Tetranychus urticae was also unaffected. In addition, cml9 mutant lines showed a wild type like reaction to the necrotrophic fungus Alternaria brassicicola. Thus, our data suggest that CML9 might be a regulator involved only in the defense against biotrophic pathogens, independent of jasmonates. In addition, our data challenge the involvement of CML9 in plant drought stress response. Taken together, we suggest that CML9 is a specialized rather than a general regulator of stress responses in Arabidopsis.
Design and analysis of refractive index sensors based on slotted photonic crystal nanobeam cavities with sidewall gratings.
Venue: Applied optics
Year: 2020

We propose and numerically investigate a refractive index sensor based on a one dimensional slotted photonic crystal nanobeam cavity with sidewall gratings for refractive index sensing in a gaseous environment. By using the three dimensional finite difference time domain method, we demonstrate that our proposed sensor simultaneously possesses a high quality factor of 3.71 \times {10^6} $3.71x106 and a high sensitivity of 508 nm/RIU (refractive index unit) at the resonant wavelength near 1583 nm, yielding a detection limit as low as 1.97 \times {10^ 6} $1.97x10 6 RIU. Moreover, the mode volume of the cavity's fundamental resonant mode is found to be as small as 0.022(\lambda /n)^3 $0.022(l/n)3, resulting in a very compact effective sensing area. We finally study and assess the effect of fabrication disorder on the performances of our proposed sensor. We believe our proposed sensor will be a promising candidate for applications not only in multiplexed biochemical sensing and multielement mixture detection, but also in optical trapping of single biomolecules or nanoparticles.
Densely Dilated Spatial Pooling Convolutional Network using benign loss functions for imbalanced volumetric prostate segmentation
Year: 2018

The high incidence rate of prostate disease poses a requirement in early detection for diagnosis. As one of the main imaging methods used for prostate cancer detection, Magnetic Resonance Imaging (MRI) has wide range of appearance and imbalance problems, making automated prostate segmentation fundamental but challenging. Here we propose a novel Densely Dilated Spatial Pooling Convolutional Network (DDSP ConNet) in encoder decoder structure. It employs dense structure to combine dilated convolution and global pooling, thus supplies coarse segmentation results from encoder and decoder subnet and preserves more contextual information. To obtain richer hierarchical feature maps, residual long connection is furtherly adopted to fuse contexture features. Meanwhile, we adopt DSC loss and Jaccard loss functions to train our DDSP ConNet. We surprisingly found and proved that, in contrast to re weighted cross entropy, DSC loss and Jaccard loss have a lot of benign properties in theory, including symmetry, continuity and differentiability about the parameters of network. Extensive experiments on the MICCAI PROMISE12 challenge dataset have been done to corroborate the effectiveness of our DDSP ConNet with DSC loss and Jaccard loss. Totally, our method achieves a score of 85.78 in the test dataset, outperforming most of other competitors.
Brexit, Prorogation and Popcorn: Implications of Miller (No 2) for New Zealand
Year: 2020

Year in Review conference, New Zealand Centre for Public Law, Victoria University of Wellington (February 2020) This address explains and critiques the UK Supreme Court's ruling in R (Miller) v Prime Minister [2019] UKSC 41, [2020] AC 373 that the prorogation of Parliament in September 2019 was unlawful and assesses its implications for New Zealand.
How Discover a Malware using Model Checking
Venue: AsiaCCS
Year: 2017

Android operating system is constantly overwhelmed by new sophisticated threats and new zero day attacks. While aggressive malware, for instance malicious behaviors able to cipher data files or lock the GUI, are not worried to circumvention users by infection (that can try to disinfect the device) there exist malware with the aim to perform malicious actions stealthy, i.e. trying to not manifest their presence to the users. This kind of malware is less recognizable, because users are not aware of their presence. In this paper we propose FormalDroid, a tool able to detect silent malicious beaviours and to localize the malicious payload in Android application. Evaluating real world malware samples we obtain an accuracy equal to 0.94.
The emerging role of water footprint in supply chain management: A critical literature synthesis and a hierarchical decision making framework
Year: 2016

Freshwater overexploitation and scarcity have led to extensive shifts in demand patterns for water friendly products. As several agricultural and industrial activities are closely intertwined with water consumption, the availability of sufficient freshwater resources constitutes a significant precondition for covering global consumer needs. In this context, the design and management of sustainable supply chains in terms of freshwater resources' preservation have emerged as major challenges in the corporate agenda. As such, the concept of water footprint as a key performance indicator of freshwater utilization has been introduced at national, corporate and product levels. In this manuscript, we first provide a critical literature synthesis concerning product water footprint assessment in order to map the state of the art research related to freshwater consumption and pollution in the agricultural and industrial sectors. Our analysis demonstrates that although water footprint assessment is a rapidly evolving research field, scientific publications focusing on a holistic approach concerning freshwater exploitation at a supply chain extent are rather limited. The findings further verify that the agrifood sector dominates global water use. In this respect, we analyse both corporate and academic literature in order to identify emerging issues on freshwater resources' management for agrifood products. Finally, we propose a first effort hierarchical decision making framework that includes water footprint mitigation policies for agrifood supply chains in order to support all stakeholders in developing a comprehensive water stewardship strategy.
Intellectual Property Rights in the Internet: Extraterritorial Recognition or New Conflict of Law Rules?
Year: 2017

O b r a z e ts ts i t i r o v a n i ia: Leanovich E. B. Prava intellektual'noi sobstvennosti v internete: eksterritorial'noe priznanie ili novye kollizionnye pravila? Zhurn. Belorus. gos. un ta. Mezhdunar. otnosheniia.