nils-herrmann/clean_scirepeval huggingface dataset:
Inhibition of insect calcium channels by huwentoxin V, a neurotoxin from Chinese tarantula Ornithoctonus huwena venom.
Venue: European journal of pharmacology
Year: 2008

The effects of huwentoxin V, an insect neurotoxic peptide from Chinese tarantula Ornithoctonus huwena venom, were studied on neuronal voltage gated ion channels. Whole cell patch clamp configuration indicated that huwentoxin V specifically inhibited high voltage activated calcium channels in adult cockroach dorsal unpaired median neurons (IC(50) approximately 219 nM) while having no evident effect on voltage gated potassium and sodium channels. Omega conotoxin GVIA is a well known neuronal N type calcium channel blocker from the venom of the sea snail Conus geographus and it also can partially block calcium currents in cockroach dorsal unpaired median neurons. In our study, huwentoxin V inhibited omega conotoxin GVIA sensitive, diltiazem sensitive and partial omega conotoxin GVIA and diltiazem resistant calcium currents elicited from insect neurons. Based on the sensitivity of calcium currents to these toxins, insect neuronal HVA calcium channels might be classified into four types: Type I, omega conotoxin GVIA sensitive and huwentoxin V sensitive; type II, diltiazem sensitive and huwentoxin V sensitive; type III, huwentoxin V sensitive but omega conotoxin GVIA and diltiazem resistant; type IV, omega conotoxin GVIA and diltiazem resistant and huwentoxin V resistant. Its specificity, incomplete inhibition and insect toxic effects make it an interesting tool for investigating insect voltage gated calcium channels and development of new insecticidal compounds.
Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide induced oxidative stress in human SH SY5Y neuroblastoma cells: role of anti apoptotic, pro survival and antioxidant genes
Venue: BMC Complementary and Alternative Medicine
Year: 2013

BackgroundThere are reports of improved metabolic outcomes due to consumption of germinated brown rice (GBR) Many of the functional effects of GBR can be linked to its high amounts of antioxidants. Interestingly, dietary components with high antioxidants have shown promise in the prevention of neurodegenerative diseases like Alzheimer's disease (AD) This effect of dietary components is mostly based on their ability to prevent apoptosis, which is believed to link oxidative damage to pathological changes in AD. In view of the rich antioxidant content of GBR, we studied its potential to modulate processes leading up to AD.MethodsThe total phenolic content and antioxidant capacity of the ethyl acetate extract of GBR were compared to that of brown rice (BR) and the cytotoxicity of both extracts were determined on human SH SY5Y neuronal cells using 3 (4,5 Dimethylthiazol 2 yl) 2,5 diphenyltetrazolium bromide (MTT) Assay. Based on its higher antioxidant potentials, the effect of the GBR extract on morphological changes due to hydrogen peroxide (H2O2) induced oxidative damage in human SH SY5Y neuronal cells was examined using inverted light microscope and fluorescence microscope by means of acridine orange propidium iodide (AO/PI) staining. Also, evaluation of the transcriptional regulation of antioxidant and apoptotic genes was carried out using Multiplex Gene Expression System.ResultsThe ethyl acetate extract of GBR had higher total phenolic content and antioxidant capacity compared to BR. The cytotoxicity results showed that GBR extract did not cause any damage to the human SH SY5Y neuronal cells at concentrations of up to 20 ppm, and the morphological analyses showed that the GBR extract (up to 10 ppm) prevented H2O2 induced apoptotic changes in the cells. Furthermore, multiplex gene expression analyses showed that the protection of the cells by the GBR extract was linked to its ability to induce transcriptional changes in antioxidant (SOD 1, SOD 2 and catalase) and apoptotic (AKT, NF Kb, ERK1/2, JNK, p53 and p38 MAPK) genes that tended towards survival.ConclusionsTaken together, the results of our study showed that the ethyl acetate extract of GBR, with high antioxidant potentials, could prevent H2O2 induced oxidative damage in SH SY5Y cells. The potential of GBR and its neuroprotective mechanism in ameliorating oxidative stress related cytotoxicity is therefore worth exploring further.
Increasing Use of Renewable Energy by Coalition Formation of Renewable Generators and Energy Stores
Venue: EUMAS/AT
Year: 2016

Renewable sources are not used to their full potential for electricity generation. Unpredictability of solar and wind power forces renewable generators to bid conservative generation amounts in a day ahead market in order to avoid fees for failure to provide generation. In this paper we propose an approach to increase the use of renewable sources, which allows renewable generators to hedge against generation unpredictability by forming coalitions with energy stores. Inside these coalitions renewable generators purchase availability of energy stores to generate power when needed. Renewable generators use this availability to avoid fees for failure to provide committed generation whenever the current generation is lower than the committed value. We experimentally show that our approach allows renewable generators to commit to 100% of the predicted generation, thus increasing the use of renewable sources. We also show that our approach generates profit incentives for both renewable generators and energy stores to form coalitions.
PERAN MEDIASI KEPUASAN KERJA PADA PENGARUH GAYA KEPEMIMPINAN DAN MOTIVASI KERJA TERHADAP KINERJA KARYAWAN PERSEROAN TERBATAS BANK PERKREDITAN RAKYAT SYARIAH SUKOWATI SRAGEN
Year: 2020

The purpose of this study was to analyze the significance of the effect of leadership style and work motivation on job satisfaction and analyze the mediating role of work satisfaction in affect leadership style and work motivation on employee performance. This type of research is survey research. The study population was 85 employees of PT. BPR Syariah Sukowati Sragen and all of them are sampled by census technique. Data sources used primary data and secondary data. Methods of data collection used questionnaires and literature study. Data analysis techniques used path analysis. The results showed that the leadership style has a significant effect on the work satisfaction. Work motivation has a significant effect on work satisfaction. Leadership style has a significant effect on the employee performance. Work motivation has a significant effect on the employee performance. Work motivation has a significant effect on the employee performance. Job satisfaction mediates the affect of the leadership style on the employee performance. Work satisfaction mediates the affect of work motivation on employee performance.
Proteomic analysis of human follicular fluid: a new perspective towards understanding folliculogenesis.
Venue: Journal of proteomics
Year: 2013

UNLABELLED Human follicular fluid is a complex body fluid that constitutes the microenvironment of developing follicles in the ovary. Follicular fluid contains a number of proteins that modulate oocyte maturation and ovulation. Information about the protein constituents of follicular fluid may provide a better understanding of ovarian physiology in addition to opening new avenues for investigating ovarian disorders. However, the composition of follicular fluid proteome remains poorly defined. In this study, we carried out SDS PAGE, OFFGEL and SCX based separation followed by LC MS/MS analysis to characterize the proteome of human follicular fluid. We report high confidence identification of 480 proteins, of which 320 have not been described previously in the follicular fluid. The identified proteins belong to diverse functional categories including growth factor and hormones, receptor signaling, enzyme catalysis, defense/immunity and complement activity. Our dataset should serve as a resource for future studies aimed at developing biomarkers for monitoring oocyte and embryo quality, pregnancy outcomes and ovarian disorders.  Proteome analysis of human follicular fluid by multi pronged approach of protein peptide fractionation revealed 480 proteins with high confidence. The identified protein may facilitate the understanding of folliculogenesis. This protein dataset should serve as a useful resource for development of biomarkers for oocyte quality, in vitro fertilization techniques and female infertility.
HUBUNGAN PERANAN GOOD COORPORATE GOVERNANCE DENGAN KEPUASAN PASIEN RAWAT JALAN DI PUSKESMAS OHEO KELURAHAN INOMOIYO KECAMATAN OHEO KABUPATEN KONAWE UTARA
Year: 2019

ABSTRAK Strategi yang diperlukan dalam meningkatkan mutu pelayanan adalah melalui implementasi Good Corporate Governance (GCG) Penelitian ini bertujuan untuk mengetahui hubungan peranan Good Coorporate Governance dengan kepuasan pasien rawat jalan di Puskesmas Oheo Kelurahan Linomoiyo Kecamatan Oheo Kabupaten Konawe Utara Tahun 2019. Objek pada penelitian ini adalah seluruh pasien rawat jalan yang berkunjung di Puskesmas Oheo. Pengambilan sampel menggunakan tekhnik Accidental Sampling dengan jumlah responden sebanyak 56 orang. Metode analisis menggunakan uji Statistik yakni uji chi square dan uji Phi. Hasil penelitian menunjukkan bahwa ada hubungan sedang antara fairness (kewajaran) dengan kepuasan pasien rawat jalan (X2 hitung 17,352, dengan nilai ph 0.557) ada hubungan lemah antara disclosure dan transparency (transparansi) dengan kepuasan pasien rawat jalan (X2 hitung 7,289, dengan nilai ph 0.361) ada hubungan sedang antara accountability (akuntabilitas) dengan kepuasan pasien rawat jalan (X2 hitung 13,763, dengan nilai ph 0.496) dan ada hubungan lemah antara responsibility (responsibilitas) dengan kepuasan pasien rawat jalan (X2 hitung 6,310, dengan nilai ph 0.336) Saran sebaiknya perlu adanya peningkatan terhadap penerapan prinsip prinsip GCG.
Precision Measurement of the Electron and Positron Fluxes in Primary Cosmic Rays with the Alpha Magnetic Spectrometer on the International Space Station
Year: 2017

The measurements of the cosmic ray \mbox{e}\pm} and \mbox{e}\mbox{e} fluxes based on the analysis of the first 30 months of data collected by the AMS 02 detector onboard the International Space Station is reviewed. The collected statistics and the resolution of the detector provide unprecedented accuracy in the analysis of the energy dependence of the \mbox{e}\pm} and the \mbox{e}\mbox{e} fluxes and of the positron fraction. The results provide new interesting information on the properties of \mbox{e}\pm} cosmic rays.
The impact of the COVID 19 epidemic on mental health of undergraduate students in New Jersey, cross sectional study
Venue: PloS one
Year: 2020

The COVID 19 pandemic has been a period of upheaval for college students. The objective of this study was to assess the factors associated with the increased levels of mental health burden among a sample of undergraduate college students in Northern New Jersey, the region of the U.S. severely impacted by the outbreak of COVID 19.  College students (N 162) enrolled in an introductory core curriculum course completed a cross sectional survey. The survey collected information on demographics, knowledge levels and sources of COVID 19 information, behavior changes, academic and everyday difficulties, and mental health measurements (depression, anxiety, somatization, and stress) Multivariable regression analysis was performed to identify factors associated with mental health outcomes.  Descriptive findings indicate that students have a fundamental knowledge of COVID 19 transmission and common symptoms. Students tend to use and trust the official sources and have changed their behaviors in accordance with public health recommendations (i.e. increased hand washing, wearing mask) However, students reported a number of academic and everyday difficulties and high levels of mental health distress. High levels of depression were associated with difficulties in focusing on academic work and with employment losses, while higher levels of anxiety were more likely to be reported by students other than freshmen and those who spend more than one hour per day looking for information on COVID 19. Inability to focus on academic work and an elevated concern with COVID 19 were more likely to be associated with higher levels of somatization, while trusting news sources was associated with lower levels of somatization. Those with higher levels of perceived stress were more likely to be females, unable to focus on academic work, and report difficulties in obtaining medications and cleaning supplies.  The COVID 19 pandemic is making a significant negative impact on mental health of college students. Proactive efforts to support the mental health and well being of students are needed.
WikiTranslate: Query Translation for Cross lingual Information Retrieval using only Wikipedia
Venue: CLEF
Year: 2008

This paper presents WikiTranslate, a system which performs query translation for cross lingual information retrieval (CLIR) using only Wikipedia to obtain translations. Queries are mapped to Wikipedia concepts and the corresponding translations of these concepts in the target language are used to create the final query. WikiTranslate is evaluated by searching with topics formulated in Dutch, French and Spanish in an English data collection. The system achieved a performance of 67% compared to the monolingual baseline.
Uma Estimativa Preliminar Das Receitas Monetarias E Nao Monetarias De Agricultores Familiares Do Vale Do Jequitinhonha
Year: 2006

O proposito deste artigo e analisar a composicao das receitas de um segmento particular da agricultura familiar do vale do Jequitinhonha: os agricultores feirantes, que fazem uma comercializacao regular da sua producao nos pequenos mercados das sedes dos municipios onde residem. O artigo investiga as origens desses diversos recursos, a contribuicao da comercializacao, da producao do autoconsumo, das transferencias e das atividades nao agricolas para o sustento dessas familias rurais. Conclui se que as rendas produtivas ocupam um lugar destacado nas receitas familiares. O artigo revela que as rendas de transferencia tem um papel virtuoso em relacao a producao, na medida em que criam condicoes para o investimento de pequenos produtores. A transferencia de rendas em montantes importantes, alem dos obvios efeitos sobre a qualidade de vida, sugerem pensar sobre os rumos da agricultura tradicional. Percebe se que transferencias desestruturam o "otimo" de reproducao familiar, ao criar um hiato de producao na faixa dos 50 aos 60 anos do casal nuclear e invalidar temporariamente a relevancia da capacitacao originaria da escolaridade como determinante na geracao de rendas. De outro lado as transferencias de rendas estruturam a agricultura familiar da regiao por colocar recursos exatamente no idoso, reforcando a tradicionalidade das relacoes internas da familia.
Prospect theory and corporate bond returns: An empirical study
Year: 2018

Since the 1980s, prospect theory has been considered as the most successful descriptive theory for decision making. In this paper, we examine the predictive power of prospect theory in the U.S. corporate bond market. The empirical evidence shows that prospect theory has significant predictive power for corporate bond returns, especially for junk bond returns. Unlike the findings for the stock market, the loss aversion component plays the most important role in predicting corporate bond returns. The probability weighting component also plays a predictive role for junk bonds, but not for investment grade bonds.
A hierarchical model of social marketing
Year: 2015

This paper aims to set out a new hierarchical and differentiated model of social marketing principles, concepts and techniques that builds on, but supersedes, the existing lists of non equivalent and undifferentiated benchmark criteria.  This is a conceptual paper that proposes a hierarchical model of social marketing principles, concepts and techniques.  This new delineation of the social marketing principle, its four core concepts and five techniques, represents a new way to conceptualize and recognize the different elements that constitute social marketing. This new model will help add to and further the development of the theoretical basis of social marketing, building on the definitional work led by the International Social Marketing Association (iSMA) Australian Association of Social Marketing (AASM) and European Social Marketing Association (ESMA)  This proposed model offers a foundation for future research to exp.
From credible threats to credible commitments? the changing face of South Korean corruption
Year: 2017

During the miracle years, the South Korean economy was hampered by rising inequality amidst widespread corruption under the institution of 'credible threats. The state used violence against private property holders to extort money in exchange for property protection. During democratization, the South Korean people were punished by both the predatory governments and chaebol owners in order to perfect free market reform by replacing credible threats with 'credible commitments. However, credible commitments between state actors, business owners, workers, consumers, and suppliers have never been fully institutionalized. The chaebol owners are now filling the vacuum of the predatory state by exerting threats over politicians and bureaucrats in the democratic state. Different forms of corruption ensued, including that of 'Samsung insurance, which politicians and bureaucrats purchased for personal safety and benefits after their terms in government expired in exchange for extending illegitimate protections to the chaebol.
Are financial incentives cost effective to support smoking cessation during pregnancy?
Venue: Addiction
Year: 2016

To investigate the cost effectiveness of up to PS400 worth of financial incentives for smoking cessation in pregnancy as an adjunct to routine health care.  Cost effectiveness analysis based on a Phase II randomized controlled trial (RCT) and a cost utility analysis using a life time Markov model.  The RCT was undertaken in Glasgow, Scotland. The economic analysis was undertaken from the UK National Health Service (NHS) perspective.  A total of 612 pregnant women randomized to receive usual cessation support plus or minus financial incentives of up to PS400 vouchers (US $609) contingent upon smoking cessation.  Comparison of usual support and incentive interventions in terms of cotinine validated quitters, quality adjusted life years (QALYs) and direct costs to the NHS.  The incremental cost per quitter at 34 38 weeks pregnant was PS1127 $1716).This is similar to the standard look up value derived from Stapleton West's published ICER tables, PS1390 per quitter, by looking up the Cessation in Pregnancy Incentives Trial (CIPT) incremental cost (PS157) and incremental 6 month quit outcome (0.14) The life time model resulted in an incremental cost of PS17 [95% confidence interval (CI) PS93, PS107] and a gain of 0.04 QALYs (95% CI 0.058, 0.145) giving an ICER of PS482/QALY $734/QALY) Probabilistic sensitivity analysis indicates uncertainty in these results, particularly regarding relapse after birth. The expected value of perfect information was PS30 million (at a willingness to pay of PS30 000/QALY) so given current uncertainty, additional research is potentially worthwhile.  Financial incentives for smoking cessation in pregnancy are highly cost effective, with an incremental cost per quality adjusted life years of PS482, which is well below recommended decision thresholds.
Tribo fatigue behaviors of steel wires under coupled tension torsion in different environmental media
Venue: Wear
Year: 2019

Tribo fatigue behaviors of carbon structural steel wires under coupled tension torsion in the tests with different tribo fatigue parameters in different environmental media were investigated in the present study. The coefficient of friction was recorded by the self made test rig. The wear depth profile was measured using three dimensional white light interferometer. Morphologies of the wear scar and fracture of steel wire were observed employing the scanning electron microscope. The electrochemical analyzer was used to investigate electrochemical corrosion characteristics of steel wire. The crack propagation of steel wire was explored employing the X ray computed tomography. The results show that coefficients of friction in different environmental media decreases by the order: air, alkaline and neutral electrolyte solutions, deionized water and acid electrolyte solution. The decrease order of maximum wear depth and increase order of fatigue life are as follows: air, acid, neutral and alkaline electrolyte solutions, and deionized water. Wear mechanisms include abrasive wear, adhesive wear, corrosion wear, fatigue wear in cases of different environmental media. The degree of electrochemical corrosion and maximum crack depth of fatigue wire are the largest in the acid electrolyte solution. The fracture is divided into zones of crack initiation, crack propagation and final fracture. Increases of tribo fatigue parameters cause overall decreases in the coefficient of friction, degree of electrochemical corrosion and fatigue life, and increases in the maximum wear depth, crack propagation rate and surface damage.
TLR4 regulates insulin resistant proteins to increase apoptosis in the mouse retina
Venue: Inflammation Research
Year: 2017

Objective and designWork in multiple organs has suggested that toll like receptor 4 (TLR4) may play a role in insulin resistance. Additional studies have shown a negative role for TLR4 on retinal health. We have previously reported that b adrenergic receptors can regulate both TLR4 signal transduction, as well as insulin signaling in the retina and in retinal endothelial cells. Thus, we hypothesized that TLR4 would regulate retinal insulin signaling.Materials and methodsWe used endothelial cell specific TLR4 knockout mice, as well as TLR4 overexpressing mice for these studies.MethodsWestern blotting and ELISA analyses were done for investigations of insulin receptor, insulin receptor substrate 1 (IRS 1) serine 307, and Akt phosphorylation, as well as cleaved caspase 3 levels in the mouse retina.ResultsWe found that loss of TLR4 led to increased insulin receptor and Akt phosphorylation, as well as decreased IRS 1Ser307 levels. In support of these results, TLR4 overexpression decreased insulin signaling and the cleavage of caspase 3.ConclusionsTherefore, these results suggest that TLR4 plays a key role in insulin signaling in the retina. Reduction of TLR4 levels may be protective to the retina.
Conflict and Cooperation in Intra Alliance Nuclear Politics: Western Europe, the United States, and the Genesis of NATO's Dual Track Decision, 1977 1979
Venue: Journal of Cold War Studies
Year: 2011

On the basis of recently released archival sources from several member states of the North Atlantic Treaty Organization (NATO) this article revisits the making of NATO's landmark 1979 dual track decision. The article examines the intersecting processes of personal, bureaucratic, national, and alliance high politics in the broader Cold War context of increasingly adversarial East West relations. The discussion sheds new light on how NATO tried to augment its deterrent capability via the deployment of long range theater nuclear missiles and why ultimately an arms control proposal to the Soviet Union was included as an equal strand. The 1979 decision owed most to West German Chancellor Helmut Schmidt's political thought and initiative. Intra alliance decision making, marked by transatlantic conflict and cooperation, benefitted from the creativity and agency of West German, British, and Norwegian officials. Contrary to popular impressions, the United States did not truly lead the process.