nils-herrmann/clean_scirepeval huggingface dataset:
Improvement of laboratory turnaround time using lean methodology.
Venue: International journal of health care quality assurance
Year: 2018

The purpose of this paper is to discuss the implementation of lean methodology to reduce the turnaround time (TAT) of a clinical laboratory in a super speciality hospital. Delays in report delivery lead to delayed diagnosis increased waiting time and decreased customer satisfaction. The reduction in TAT will lead to increased patient satisfaction, quality of care, employee satisfaction and ultimately the hospital's revenue.  The generic causes resulting in increasing TAT of clinical laboratories were identified using lean tools and techniques such as value stream mapping (VSM) Gemba, Pareto Analysis and Root Cause Analysis. VSM was used as a tool to analyze the current state of the process and further VSM was used to design the future state with suggestions for process improvements.  This study identified 12 major non value added factors for the hematology laboratory and 5 major non value added factors for the biochemistry lab which were acting as bottlenecks resulting in limiting throughput. A four month research study by the authors together with hospital quality department and laboratory staff members led to reduction of the average TAT from 180 to 95minutes in the hematology lab and from 268 to 208 minutes in the biochemistry lab.  Very few improvement initiatives in Indian healthcare are based on industrial engineering tools and techniques, which might be due to a lack of interaction between healthcare and engineering. The study provides a positive outcome in terms of improving the efficiency of services in hospitals and identifies a scope for lean in the Indian healthcare sector.  Applying lean in the Indian healthcare sector gives its own potential solution to the problem caused, due to a wide gap between lean accessibility and lean implementation. Lean helped in changing the mindset of an organization toward providing the highest quality of services with faster delivery at an optimal cost.  This paper is an effort to reduce the gap between healthcare and industrial engineering and enhancing the use of lean practices in Indian healthcare. The study is motivated toward implementing lean methodology successfully in services.
A general theory of spatial relations to support a graphical tool for visual information extraction
Venue: J. Vis. Lang. Comput.
Year: 2013

In this paper we present a general spatial composition framework which allows one to model the graphical objects and the spatial relations of a large class of visual languages. The new formalism has been implemented within the SRQ tool, a software system for the Visual Information Extraction, enabling it to work on a wider range of domains. In particular, in the paper we describe the application of SRQ to geospatial data.
Cuidados Paliativos em Pacientes com Cancer Avancado e Covid 19
Year: 2020

O objetivo e que este manuscrito possa servir como mola propulsora para o desenvolvimento de estrategias de cuidado que aliem o controle de sintomas as questoes relativas a humanizacao da assistencia, possibilitando que as demandas dessa populacao sejam atendidas, com consequente qualidade de vida e de morte.
TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system
Venue: Virchows Archiv
Year: 2007

Criteria for the staging and grading of neuroendocrine tumors (NETs) of midgut and hindgut origin were established at the second Consensus Conference in Frascati (Rome) organized by the European Neuroendocrine Tumor Society (ENETS) The proposed tumor node metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow our previous proposal for foregut tumors. The new TNM classifications for NETs of the ileum, appendix, colon, and rectum, and the grading system were designed, discussed, and consensually approved by all conference participants. These proposals need to be validated and are meant to help clinicians in the stratification, treatment and follow up of patients.
Modelling the Dissociation Dynamics and Threshold Photoelectron Spectra of Small Halogenated Molecules
Year: 2013

The two experimental aspects of the imagining photoelectron photoion coincidence (iPEPICO) apparatus which is stationed at the VUV Beamline at the Swiss Light Source, a synchrotron source, have been used to investigate the fundamental properties of small molecules in the gas phase. The fast and slow dissociation dynamics of halogenated methanes and fluorinated ethenes have been investigated using threshold photoelectron photoion coincidence (TPEPICO) techniques. Rate constants and accurate 0 K appearance energies for the formation of subsequent daughter ions have been determined. The latter values have been used in conjunction with ab initio calculations to derive updated enthalpies of formation. The valence threshold photoelectron spectra of four fluorinated ethenes have been recorded. The spectra have been analysed using Franck Condon simulations to model the vibrational structure, and assign the spectra, sometimes revising previous assignments. The potential energy surfaces of the ground and excited electronic states have been explored to uncover their various intriguing dissociative photodissociation mechanisms.
DESCONFORTOS ESPERADOS E VIVENCIADOS POR PACIENTES NO POS OPERATORIO IMEDIATO
Year: 2018

Objetivo: verificar os desconfortos esperados e vivenciados por pacientes no pos operatorio imediato. Metodo: estudo descritivo, quantitativo, pre e pos teste, realizado em dois hospitais publicos. No pre operatorio, os pacientes enumeraram os desconfortos que esperavam vivenciar, dentre dez desconfortos mais comuns, citados em literatura. No pos operatorio imediato indicavam quais desconfortos realmente vivenciaram e atribuiram valores monetarios ficticios para evita los. A coleta de dados foi realizada de agosto a outubro de 2016.  participaram da pesquisa 160 pacientes. Os desconfortos esperados, vivenciados e com maiores valores monetarios ficticios para preveni los foram dor (5.870) sede (2.255) e fome (2.125) Estes desconfortos apresentaram correlacao significativa entre seu ranqueamento e o valor distribuido para sua prevencao. Conclusao: a dor foi o desconforto mais antecipado e o mais vivenciado, assim como o que teve maior valor atribuido para sua prevencao. Os desconfortos vivenciados sede, fome, fraqueza e frio ultrapassaram as expectativas de desconfortos esperados no pos operatorio imediato.  Assistencia perioperatoria. Cuidados pos operatorios. Complicacoes pos operatorias. Dor. Sede.
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Year: 2017

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Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
Venue: Journal of neuropathology and experimental neurology
Year: 2009

Since the 1920s, it has been known that the repetitive brain trauma associated with boxing may produce a progressive neurological deterioration, originally termed dementia pugilistica, and more recently, chronic traumatic encephalopathy (CTE) We review 48 cases of neuropathologically verified CTE recorded in the literature and document the detailed findings of CTE in 3 professionalathletes, 1 football player and 2 boxers. Clinically, CTE is associated with memory disturbances, behavioral and personality changes, parkinsonism, and speech and gait abnormalities. Neuropathologically, CTE is characterized by atrophy of the cerebral hemispheres, medial temporal lobe, thalamus, mammillary bodies, and brainstem, with ventricular dilatation and a fenestrated cavum septum pellucidum. Microscopically, there are extensive tau immunoreactive neurofibrillary tangles, astrocytic tangles, and spindle shaped and threadlike neurites throughout the brain. The neurofibrillary degeneration of CTE is distinguished from other tauopathies by preferential involvement of the superficial cortical layers, irregular patchy distribution in the frontal and temporal cortices, propensity for sulcal depths, prominent perivascular, periventricular, and subpial distribution, and marked accumulation of tau immunoreactive astrocytes. Deposition of &bgr; amyloid, most commonly as diffuse plaques, occurs in fewer than half the cases. Chronic traumatic encephalopathy is a neuropathologically distinct slowly progressive tauopathy with a clear environmental etiology.
Medical and Surgical Education Challenges and Innovations in the COVID 19 Era: A Systematic Review.
Venue: In vivo
Year: 2020

The aim of this systematic review was to identify the challenges imposed on medical and surgical education by the COVID 19 pandemic, and the proposed innovations enabling the continuation of medical student and resident training. A systematic review on the MEDLINE and EMBASE databases was performed on April 18th, 2020, and yielded 1288 articles. Sixty one of the included manuscripts were synthesized in a qualitative description focused on two major axes, "challenges" and "innovative solutions" and two minor axes, "mental health" and "medical students in the frontlines" Shortage of personal protective equipment, suspension of clinical clerkships and observerships and reduction in elective surgical cases unavoidably affect medical and surgical education. Interesting solutions involving the use of virtual learning, videoconferencing, social media and telemedicine could effectively tackle the sudden cease in medical education. Furthermore, trainee's mental health should be safeguarded, and medical students can be involved in the COVID 19 clinical treatment if needed.
Mastery Motivation in Infancy and Early Childhood: The Consistency and Variation of Its Stability and Predictability of General Competence
Year: 2017

Infant mastery motivation has been regarded as an important developmental precursor for later achievement and adaptability. This longitudinal study examined the cross wave stablility of mastery motivation and its association with general competence in different periods of infancy and early childhood. Fifty three 10 month old infants and their mothers participated in this study. Children's mastery motivation and general competence were rated by mothers using the Dimensions of Mastery Questionnaire at each wave of testing at 10, 21, 26, 37, and 53 months. The cross wave analyses of stability and predictability were conducted on three sets of 16month intervals (i.e. 10 to 26 mo. 21 to 37 mo. and 37 to 53 mo. and from 10 to 53 months of age. Results indicated that children's task persistence, especially in the cognitive and physical domains, remained stable throughout infancy and early childhood. The domain of negative reactions to failure showed consistent stability in all three sets of 16 month intervals while mastery pleasure was only stable when children were younger than two years of age. In terms of the predictability of mastery motivation, task persistence remained a significant predictor of competence across different periods in infancy and early childhood even after controlling for participants' demographic backgrounds and prior competence.
The impact of a hospital electronic prescribing and medication administration system on medication administration safety: an observational study
Venue: BMC Health Services Research
Year: 2017

BackgroundThe aim of the study was to explore the impact of the implementation of an electronic prescribing and medication administration system (ePA) on the safety of medication administration in an inpatient hospital setting. Objectives were to compare the prevalence and types of: 1) medication administration errors, and 2) documentation discrepancies, between a paper and an ePA system. Additionally, we wanted to describe any observed changes to medication administration practices.MethodsThe study was based on an elderly medicine ward in an English hospital. From December 2014 to June 2015, nurses' medication administration rounds were observed every 5 days before and after ePA implementation using an interrupted time series approach. Medication administration error and documentation discrepancy rates pre versus post ePA were analysed descriptively and chi squared tests used to test for any difference; segmented regression analysis was used to determine changes in longitudinal trend.ResultsObservations were made at 15 pre and 15 post ePA implementation time points. Pre ePA on paper, there were 18 medication administration errors in 428 opportunities for error (4.2% 95% confidence interval 2.3 6.1% and with ePA there were 18 in 528 (3.4% 95% confidence interval 1.9 5.0% p 0.64) Regarding documentation, pre ePA on paper there were 5 discrepancies in 460 observed documentations (1.1% 95% confidence interval 0.1 2.0% with ePA there were 18 in 557 (3.2% 95% confidence interval 1.8 4.7% p 0.04) The most common electronic documentation discrepancy was documentation that a dose had been administered when it had not. Segmented regression analysis was unable to detect any significant longitudinal changes. Changes to working practices post ePA were observed, such as nurses demonstrating less consistent self checking when preparing and administering medications.ConclusionsFindings suggest no change in medication error rate, although ePA encourages certain types of errors and mitigates others. There was a statistically significant increase in documentation discrepancies which is likely to be due to adoption of new working practices with ePA.
Disentangling the effects of parent material and litter input chemistry on molecular soil organic matter composition in converted forests in Western Europe
Venue: Organic Geochemistry
Year: 2019

By storing carbon in the soil, forests contribute to climate change mitigation. Edaphic (soil related) factors, such as soil pH, as well as tree species affect forest carbon cycles, but are difficult to disentangle. We studied how conversion of deciduous stands to mono culture spruce plantations affected the soil organic matter (SOM) composition along a lithological gradient in the Mullerthal (Luxembourg) and Gaume (south east Belgium) regions. Parent materials in these regions range from decalcified sands to calcareous marls. A twin plot setup of adjacent deciduous and coniferous stands on the same parent material was used to evaluate the effect of edaphic factors versus litter input differences on SOM composition and soil organic carbon (SOC) stocks. Lignin and cutin/suberin molecular proxies were identified with thermally assisted hydrolysis and methylation (THM) to distinguish litter sources (coniferous vs deciduous and leaf litter vs roots) in the studied stands. In this study, SOC stocks were influenced more by parent material than by forest type. Lignin yield, composition and degradation state were influenced both by litter input chemistry and edaphic context. There appear to be important interaction effects between the two, as the relative importance of parent material and litter quality was site specific. We therefore advice that carbon stock models include data on both vegetation history as well as edaphic context.
a MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart
Venue: Journal of molecular and cellular cardiology
Year: 2016

In order to maintain an efficient, energy producing network in the heart, dysfunctional mitochondria are cleared through the mechanism of autophagy, which is closely linked with mitochondrial biogenesis; these, together with fusion and fission comprise a crucial process known as mitochondrial turnover. Until recently, the lack of molecular tools and methods available to researchers has impeded in vivo investigations of turnover. To investigate the process at the level of a single mitochondrion, our laboratory has developed the MitoTimer protein. Timer is a mutant of DsRed fluorescent protein characterized by transition from green fluorescence to a more stable red conformation over 48 h, and its rate of maturation is stable under physiological conditions. We fused the Timer cDNA with the inner mitochondrial membrane signal sequence and placed it under the control of a cardiac restricted promoter. This construct was used to create the alpha MHC MitoTimer mice. Surprisingly, initial analysis of the hearts from these mice demonstrated a high degree of heterogeneity in the ratio of red to green fluorescence of MitoTimer in cardiac tissue. Further, scattered solitary mitochondria within cardiomyocytes display a much higher red to green fluorescence (red shifted) relative to other mitochondria in the cell, implying a block in import of newly synthesized MitoTimer likely due to lower membrane potential. These red shifted mitochondria may represent older, senescent mitochondria. Concurrently, the cardiomyocytes also contain a subpopulation of mitochondria that display a lower red to green fluorescence (green shifted) relative to other mitochondria, indicative of germinal mitochondria that are actively engaged in import of newly synthesized mito targeted proteins. These mitochondria can be isolated and sorted from the heart by flow cytometry for further analysis. Initial studies suggest that these mice represent an elegant tool for the investigation of mitochondrial turnover in the heart.
EFECTIVIDAD DE UNA ESTRATEGIA DE INTERVENCION SANITARIA PARA LA PROMOCION DE LA SALUD EN LA CAMPANA DE VACUNACION CONTRA LA HEPATITIS B
Year: 2008

Mejorar la efectividad de la campana de vacunacion luego de aplicar el diseno de intervencion sanitaria estrategico local con la finalidad de promover la salud en la campana de vacunacion contra la hepatitis B. Diseno: Estudio de tipo cuasi experimental, descriptivo, longitudinal.  Centro educativo nacional perteneciente al distrito de Villa el Salvador en coordinacion con el centro de salud San Martin de Porres perteneciente a la red de salud de Lima. Participantes: Estudiantes escolares atendidos durante la campana de vacunacion cuyas edades oscilan ente 5 y 16 anos.  Aplicacion del plan de ejecucion de la campana de vacunacion disenado en coordinacion con los actores sociales comunitarios, revision del libro de vacunados por el centro de salud. Principales medidas de resultados: Frecuencia de vacunados de la primera y segunda dosis, prueba Z para proporciones.  La eficacia fue medida en funcion de los porcentajes de vacunados. Asi, en la primera intervencion fue 40.1% en la segunda fue 60.8% de vacunados .Se observo diferencia significativa estadistica p=0.02 (p<0.05) entre la primera intervencion y la segunda.  La intervencion sanitaria estrategica local de la segunda vacunacion fue efectiva al observarse un incremento del porcentaje de vacunados luego de la aplicacion del diseno de intervencion.
Potensi Khamir Pada Limbah Tebu Sebagai Agens Bioremediasi Penanggulangan Penyakit Abiotik Akibat Kelebihan Unsur Timbal (Pb)
Year: 2016

Pabrik gula dalam pengolahanya selalu menghasilkan limbah logam berat Pb. Logam tersebut berasal dari bahan penjernih Pb asetat yang digunakan untuk analisa gula dalam pengawasan pabrikasi. Bahan penjernih tersebut telah digunakan sudah cukup lama, sejak satu abad yang lalu. Diperkirakan untuk pabrik gula yang berkapasitas 4000 ton tebu per hari diperlukan tidak kurang dari 100 kg Pb per musim giling (Syahputra et al. 2011) Kurangnya manajemen sektor industri dengan ketiadaan instalasi pengolahan air limbah berpotensi menimbulkan pencemaran lingkungan terutama air sebagai sumber irigasi lahan pertanian, selain itu penggunan pupuk dari limbah tebu dapat meracuni lahan pertanian. Pencemaran Pb pada lahan pertanian menyebabkan fitotoksitas pada tanaman budidaya. Beberapa penelitian menunjukkan bahwa pencemaran unsur Pb mengakibatkan menurunnya pertumbuhan dan produksi tanaman serta diikuti dengan gejala yang tampak (visible symptoms) Unsur Pb dapat membahayakan apabila masuk ke dalam sistem metabolisme tanaman dalam jumlah yang melebihi ambang batas. Bioremediasi adalah proses detoksifikasi bahan kimia berbahaya pada lingkungan, menggunakan mikroorganisme atau tanaman fitoremediasi. Penelitian ini bertujuan untuk mengetahui potensi khamir pada limbah tebu sebagai agens bioremediasi unsur Pb. Penelitian dilaksanakan di Laboratorium Penyakit Tumbuhan Jurusan Hama dan Penyakit Tanaman, Fakultas Pertanian, Universitas Brawijaya, Malang pada bulan Febuari sampai Mei 2016. Khamir diisolasi dari limbah tebu yang tercemar unsur Pb di PG. Pesantren Baru, Kota Kediri menggunakan media YEPD yang telah dicemari Pb 1 ppm. Hasil isolasi khamir yang diperoleh dari limbah tebu sebanyak tujuh isolat, dari limbah ampas tebu (bagasse) yaitu khamir Metschnikowia sp.1, Pichia sp. dan Candida sp. dari limbah blotong yaitu Metschnikowia sp. 2 dan Cryptococcus sp. dan dari limbah tetes (molase) yaitu Debaryomyces sp. dan Rhodotorula sp. Semua isolat khamir yang ditemukan diuji untuk mengetahui potensi dalam menurunkan unsur Pb. Hasil pengamatan parameter larutan uji, khamir mampu mempengaruhi derajat keasaman (pH) dan perubahahan fisik larutan dilihat dari perubahan optical dencity (OD) adanya uap air, perubahan aroma, endapan dan kekeruhan pada media uji seiring menurunya unsur Pb.
Earthquake Loading Characterisation for Regions of Low to Moderate Seismicity
Year: 2017

This article is the first in the special theme session (of the ASEM17 conference) which is aimed at helping engineering practitioners who are engaged in the structural design of buildings to attend to seismic considerations in a tectonically stable region of low or moderate seismic activities. The earthquake loading model is to be decided first in the design process and is the subject matter of the article As for all articles in the series no prior knowledge on earthquake engineering and structural dynamics is assumed of the readers. Basic principles and generic modelling techniques are explained in the early part of the article for the benefit of those who are not already familiar with the fundamentals. Later sections are fully devoted to the modelling of earthquake actions on rock, and flexible soil, sites in a low to moderate seismicity environment. These are important key features which should be of interests to both the regulators (code drafters) and the design practitioners.