Management of children with COVID 19: experiences from China
Venue: World Journal of Pediatrics
Year: 2020

The coronavirus disease 2019 (COVID 19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) is a major public health event. As a special population, children have special respiratory tract structure characteristics, immature immune system, and susceptibility to respiratory virus infections. Therefore, it is highly important for clinicians to treat the infected children cautiously despite most pediatric patients have milder symptoms and better prognosis compared with the adult patients. The June issue of "World Journal of Pediatrics" covers multiple COVID 19 related papers and other important studies. All the COVID 19 related papers are free to access. This issue highlights the efforts towards strategies and management of COVID 19 in children in China, which include recommendations for infection control and management in children with COVID 19, research articles for case sharing, and viewpoints for COVID related important issues. The recommendations for prevention, diagnosis, and treatment of children with COVID 19 summarized epidemiology, clinical characteristics, diagnostic criteria, clinical classifications, differential diagnosis, and treatments [1 3] The early warning indicators for severe pediatric cases have also been summarized in the updated version which is of utmost importance for clinical practice. These recommendations provide systemic guidance on managing COVID 19 in children, and the optimized strategies for managing pediatric patients at various severities. These recommendations are summaries of experiences in managing COVID 19 in China, which are valuable for better prevention, diagnosis, and treatment of COVID 19 in children worldwide. Besides the above recommendations for clinical experience sharing, a review by Ma et al.  focusing on the management strategies of neonatal jaundice during the COVID 19 pandemic is also included. Three research articles cover severe cases, infant cases, and family cluster cases. The first article by Sun et al.  presents detailed clinical data of eight severe or critically ill cases with COVID 19. The authors report a cytokine storm in these severe cases, which is even more serious in critically ill cases, which indicates that the early identification of the specific features of severe cases and timely treatment are of vital importance. The next article by Sun et al.  retrieves and analyzes the clinical data of 36 infants with COVID 19 in detail, and discovers that lymphocytosis, elevated CD4 and IL 10, and co infections are common in infants with COVID 19, which are different from adults. In the final article, Ji et al.  report two confirmed pediatric cases from two family clusters. The authors describe clinical features and laboratory examination results of the two children, who present with mild symptoms and recover quickly after general and symptomatic treatments. Their study highlights the importance that pediatricians should be vigilant in treating patients with family cluster. Four viewpoints deserving attention and discussion are concerned with COVID 19 related issues including pharmaceutical care recommendations for antiviral treatments, calling for clinical trial in pediatric patients, children's physical and mental needs during the epidemic, and management workflow of neonates with COVID 19 [8 11] We hope that this issue will provide clinicians with an up to date and comprehensive overview of the strategies and management for children with COVID 19, and will provide an exchange platform for global knowledge sharing.