nils-herrmann/clean_scirepeval huggingface dataset:
Interaction of flavonols with human serum albumin: a biophysical study showing structure activity relationship and enhancement when coated on silver nanoparticles
Venue: Journal of biomolecular structure dynamics
Year: 2019

Binding affinities of flavonols namely quercetin, myricetin, and kaempferol to human serum albumin (HSA) were determined fluorimetrically and the order was observed to be myricetin quercetin kaempferol demonstrating structure activity relationship. Quercetin coated silver nanoparticles (AgNPs) show higher binding affinity to HSA compared to free quercetin with binding constants 6.04 x 107 M 1 and 4.2 x 106 M 1, respectively. Using site specific markers it is concluded that free quercetin and that coated on AgNPs bind at different sites. Significant structural changes in circular dichroism (CD) spectra of HSA were recorded with quercetin coated AgNPs compared to free quercetin. These results were further substantiated by time resolved fluorescence spectroscopy where fluorescence life time of the tryptophan residue in HSA quercetin coated AgNPs complex decreased to 3.63 ns from 4.22 ns in HSA quercetin complex. Isothermal calorimetric studies reveal two binding modes for quercetin coated AgNPs and also higher binding constants compared to free quercetin. These higher binding affinities are attributed to altered properties of quercetin when coated on AgNPs enabling it to reach the binding sites other than site II where free quercetin mainly binds.
Multi Resource Allocation for Network Slicing
Venue: IEEE/ACM Transactions on Networking
Year: 2020

Among the novelties introduced by 5G networks, the formalization of the 'network slice' as a resource allocation unit is an important one. In legacy networks, resources such as link bandwidth, spectrum, computing capacity are allocated independently of each other. In 5G environments, a network slice is meant to directly serve end to end services, or verticals: behind a network slice demand, a tenant expresses the need to access a precise service type, under a fully qualified set of computing and network requirements. The resource allocation decision encompasses, therefore, a combination of different resources. In this paper, we address the problem of fairly sharing multiple resources between slices, in the critical situation in which the network does not have enough resources to fully satisfy slice demands. We model the problem as a multi resource allocation problem, proposing a versatile optimization framework based on the Ordered Weighted Average (OWA) operator, that takes into account different fairness approaches. We show how, adapting the OWA utility function, our framework can generalize classical single resource allocation methods, existing multi resource allocation solutions at the state of the art, and implement novel multi resource allocation solutions. We compare analytically and by extensive simulations the different methods in terms of fairness and system efficiency.
The evolution of the Buddhist raka genre in the light of new evidence from Gandhara The Manasvi nagaraja sutra from the Bajaur Collection of Kharohi Manuscripts
Year: 2014

This article examines the *Manasvi nagaraja sutra, a unique text in the raksa genre of Buddhist literature dating to the early centuries of the common era. In addition to exploring special features of the vocabulary and meaning of this text, the article places the *Manasvi nagaraja sutra in the wider context of Buddhist textual and ritual practice in the first, second and third centuries CE.
Funcao executiva e desempenho em leitura em criancas do ensino fundamental
Year: 2013

A leitura envolve varios processos, que vao da decodificacao das letras ate a compreensao do texto. Estudos tem buscado identificar os processos que contribuem para a leitura, dentre eles a funcao executiva (FE) que e o conjunto de habilidades que permitem direcionar o comportamento. Para analisar a relacao entre FE e leitura, foram realizados tres estudos. O primeiro analisou a producao cientifica sobre a relacao entre dificuldade de leitura (DL) e FE. Observou se que essa relacao ainda e controvertida, existindo tanto pesquisas que a corroboraram quanto aquelas que nao observaram tal associacao. O segundo avaliou o desempenho em leitura de alunos do 2o ano do Ensino Fundamental, associando o ao resultado da escola em um sistema estadual de avaliacao de alfabetizacao. Eles foram divididos em grupo com DL, grupo medio e com Talento em Leitura (TL) Observou se um numero preocupante de alunos com DL, denotando fracasso das escolas em alfabetizar esses alunos. Porem, observou se que o TL se manifesta ate mesmo em escolas com qualidade de ensino baixa. O terceiro comparou o desempenho em FE desses tres grupos. Nao foram encontradas associacoes entre as variaveis. As implicacoes e limitacoes dessas pesquisas sao discutidas.
PENETAPAN KADAR FLAVONOID EKSTRAK DAUN SINGKIL (Premna corymbosa) BERDASARKAN VARIASI SUHU DAN WAKTU PENGERINGAN SIMPLISIA
Year: 2018

Daun singkil memiliki kandungan senyawa metabolit sekunder berupa flavonoid, saponin, tanin dan triterpenoid/steroid. Pengeringan merupakan salah satu tahap pembuatan simplisia yang dilakukan agar simplisia tidak mudah rusak. Penelitian ini bertujuan untuk mengetahui kadar flavonoid ekstrak etanol daun singkil berdasarkan variasi suhu dan waktu pengeringan simplisia. Tahapan penelitian meliputi pengambilan sampel, determinasi tumbuhan, pembuatan simplisia dengan pengeringan oven pada suhu 50 oC dan 70 oC dengan waktu 8 dan 10 jam, ekstraksi secara maserasi, skrining fitokimia ekstrak, penetapan kadar flavonoid menggunakan Spektrofotometri UV Vis. Hasil penelitian menunjukkan bahwa ekstrak etanol daun singkil memiliki senyawa metabolit sekunder yaitu tanin, flavonoid, saponin dan terpenoid/steroid. Kadar rata rata flavonoid ekstrak etanol daun singkil berdasarkan suhu dan waktu pengeringan simplisia berturut turut mulai dari yang tertinggi adalah suhu 50oC waktu 10 jam sebesar 1,54% suhu 70 oC waktu 8 jam sebesar 1,50% suhu 70 oC waktu 10 jam sebesar 1,38% dan suhu 50 oC waktu 8 jam sebesar 0,96%
End of life decision making capacity in an elderly patient with schizophrenia and terminal cancer
Venue: South African family practice official journal of the South African Academy of Family Practice/Primary Care
Year: 2020

Medical practitioners are confronted daily with decisions about patients' capacity to consent to interventions. To address some of the pertinent issues with these assessments, the end of life decision making capacity of a 72 year old female with treatment resistant schizophrenia and terminal cancer is discussed, as are the role of the treating clinician and the importance of health related values. There is a recommendation that the focus of these assessments can rather be on practical outcomes, especially when capacity issues arise. This implies that the decision making capacity of the patient is only practically important when the treatment team is willing to proceed against the patient's wishes. This shifts the focus from a potentially difficult assessment to the simpler question of whether the patient's capacity will change the treatment approach. Clinicians should attend to any possible underlying issues, instead of focusing strictly on capacity. Compared to the general populations people with serious mental illness (SMI) have higher rates of physical illness and die at a younger age, but they do not commonly access palliative care services. Conversations about end of life care can occur without fear that a person's psychiatric symptoms or related vulnerabilities will undermine the process. More research about palliative care and advance care planning for people with SMI is needed. This is even more urgent in light of the coronavirus disease 2019 (COVID 19) pandemic, and South African health services should consider recommendations that advanced care planning should be routinely implemented. These recommendations should not only focus on the general population and should include patients with SMI.
Firm level political risk and asymmetric volatility
Year: 2018

This paper examines whether proxies of political risk exposure at the firm level can predict the aggregate stock market volatility. Utilizing a nonparametric causality in quantiles test which not only guards against misspecification due to nonlinearity, but also tests for causality over the entire conditional distribution of the realized volatilities, we show that political risk exposure can serve as a strong predictor of bad realized volatility, while the causal effects are non existent in the case of overall and good realized volatilities. Our findings provide novel insight to the well documented asymmetric volatility puzzle and the effect of political uncertainty on stock market fluctuations via the investor attention channel. The results also suggest that political risk exposure could be a contributing factor to jump risk in the cross section of returns.
High density DNA methylation array with single CpG site resolution.
Venue: Genomics
Year: 2011

We have developed a new generation of genome wide DNA methylation BeadChip which allows high throughput methylation profiling of the human genome. The new high density BeadChip can assay over 480K CpG sites and analyze twelve samples in parallel. The innovative content includes coverage of 99% of RefSeq genes with multiple probes per gene, 96% of CpG islands from the UCSC database, CpG island shores and additional content selected from whole genome bisulfite sequencing data and input from DNA methylation experts. The well characterized Infinium(r) Assay is used for analysis of CpG methylation using bisulfite converted genomic DNA. We applied this technology to analyze DNA methylation in normal and tumor DNA samples and compared results with whole genome bisulfite sequencing (WGBS) data obtained for the same samples. Highly comparable DNA methylation profiles were generated by the array and sequencing methods (average R2 of 0.95) The ability to determine genome wide methylation patterns will rapidly advance methylation research.
Victorian Mages: Robert Browning's "Pietro of Abano" as a Critical Corollary to Alfred Tennyson's Merlin
Venue: Anglia
Year: 2019

Against the backdrop of Victorian celebrity culture, Robert Browning and Alfred Tennyson conjure the literary trope of the magician in order to convey their poetic choices and to examine the relationship between the poet and his audience. Whereas Browning's magician, "Pietro of Abano" of Dramatic Idyls (1880) is subversive, odd and persecuted, the Poet Laureate's Merlin of the Idylls of the King (1859 1875) is acknowledged and well admired. This essay will explore Browning's Pietro as a critical response to Tennyson's Merlin, reflecting the complex personal relationship between the two poets, their stylistic differences and their dissimilar reception by their contemporaries.
Energy Efficient Power Allocation for Underlay Cognitive Radio Systems
Venue: IEEE Transactions on Cognitive Communications and Networking
Year: 2015

We present a power allocation framework for spectrum sharing cognitive radio (CR) systems based on maximizing the energy efficiency (EE) First, we show that the relation between the EE and the spectral efficiency (SE) is strictly increasing in contrast with the SE EE tradeoff discussed in the literature. We also solve a nonconvex problem and explicitly derive the optimal power for the proposed average EE under either a peak or an average power constraint. We apply our results to the underlay CR systems where the power is limited by an additional interference constraint. When the instantaneous channel is not available, we provide a necessary and sufficient condition for the optimal power and present a simple suboptimal power. In the numerical results, we show that the proposed EE corresponds to a higher SE at midrange and high power regime compared to the classical EE. We also show that the suboptimal solution is very close to the optimal solution. In addition, we deduce that the absence of instantaneous CSI affects the EE and the SE at high power regime compared to full CSI. In the CR context, we show that the interference threshold has a minimal effect on the EE compared to the SE.
Species level identification of trypanosomes infecting Australian wildlife by High Resolution Melting Real Time Quantitative Polymerase Chain Reaction (HRM qPCR)
Venue: International journal for parasitology. Parasites and wildlife
Year: 2020

Conventional nested PCR and Sanger sequencing methods are currently the gold standards for detecting trypanosomes in wildlife. However, these techniques are time consuming and can often overlook mixed infections. True trypanosome prevalence can thus be underrepresented. Here, we designed an 18S rDNA based real time quantitative PCR (qPCR) assay coupled with High Resolution Melting Analysis (HRMA) to detect and discriminate three Trypanosoma species (T. copemani, T. noyesi, and T. vegrandis) commonly infecting Australian marsupials. A total of 68 genetically characterised samples from blood and tissue were used to validate the High Resolution Melting Real Time Quantitative Polymerase Chain Reaction (HRM qPCR) assay. A further 87 marsupial samples consisting of blood, tissue and in vitro cultures derived from wildlife blood samples, were screened for the first time using this assay, and species identity confirmed using conventional PCR and Sanger sequencing. All three Trypanosoma species were successfully detected in pure cultures using the HRM qPCR assay, and in samples containing mixed trypanosome infections. Of the 87 marsupial samples screened using the HRM qPCR assay, 93.1% were positive for trypanosomes, and 8.0% contained more than one trypanosome species. In addition to the three targeted Trypanosoma species, this assay was also able to detect and identify other native and exotic trypanosomes. The turnaround time for this assay, from sample preparation to obtaining results, was less than 2 h, with a detection limit of 10 copies of the amplicon in a reaction for each of the targeted trypanosome species. This more rapid and sensitive diagnostic tool provides a high throughput platform for the detection, identification and quantification of trypanosome infections. It will also improve understanding of host diversity and parasite relationships and facilitate conservation management decisions.
1 Music, Memory, and Identity in Full Gospel Trinidad
Year: 2019

This ethnographic study of Trinidadian gospel music engages the multiple musical styles circulating in the nation's Full Gospel community and illustrates the carefully negotiated and contested spaces that they occupy in relationship to questions of identity. By exploring gospelypso, jamoo "Jehovah's music" gospel dancehall, and North American gospel music, along with the discourses that surround performances in these styles, the book illustrates the extent to which value, meaning, and appropriateness are continually circumscribed and reinterpreted in the process of coming to terms with what it looks and sounds like to be a Full Gospel believer in Trinidad. The local, regional, and transnational implications of these musical styles, moreover, are read in relationship to their impact on belief (and vice versa) revealing the particularly nuanced poetics of conviction that drive both apologists and detractors of these styles. The book sets the investigation against a historical narrative and introduces a theoretical approach that the book calls the "ethics of style" a model that privileges the convictions embedded in this context and which emphasizes their role in shaping the terms upon which identity is continually being constructed in Trinidad. The result is an extended meditation on the convictions that lie behind the creation and reception of style in
Putting the pieces together: Integration for forest landscape restoration implementation
Year: 2019

The concept of forest landscape restoration (FLR) is being widely adopted around the globe by governmental, non governmental agencies, and the private sector, all of whom see FLR as an approach that contributes to multiple global sustainability goals. Originally, FLR was designed with a clearly integrative dimension across sectors, stakeholders, space and time, and in particular across the natural and social sciences. Yet, in practice, this integration remains a challenge in many FLR efforts. Reflecting this lack of integration are the continued narrow sectoral and disciplinary approaches taken by forest restoration projects, often leading to marginalisation of the most vulnerable populations, including through land dispossessions. This article aims to assess what lessons can be learned from other associated fields of practice for FLR implementation. To do this, 35 scientists came together to review the key literature on these concepts to suggest relevant lessons and guidance for FLR. We explored the following large scale land use frameworks or approaches: land sparing/land sharing, the landscape approach, agroecology, and socio ecological systems. Also, to explore enabling conditions to promote integrated decision making, we reviewed the literature on understanding stakeholders and their motivations, tenure and property rights, polycentric governance, and integration of traditional and Western knowledge. We propose lessons and guidance for practitioners and policymakers on ways to improve integration in FLR planning and implementation. Our findings highlight the need for a change in decision making processes for FLR, better understanding of stakeholder motivations and objectives for FLR, and balancing planning with flexibility to enhance social ecological resilience.
LEISHMANIOSE VISCERAL EM CANINO DE SINOP, MATO GROSSO
Year: 2017

A leishmaniose visceral canina (LVC) e uma doenca progressiva cronica, e frequentemente fatal. E uma zoonose de grande impacto na saude publica, causada pelo Leishmania chagasi um protozoario transmitido pela picada de flebotomideo, tendo como principal vetor o Lytzomyia longipalpis (mosquito palha) O trabalho trata se de lesoes macroscopicas e microscopicas em caso de leishmaniose visceral canina, no municipio de Sinop, Mato Grosso. Canino, femea, 2 anos de idade foi encaminhado para laboratorio de patologia animal da Universidade Federal de Mato Grosso campus universitario de Sinop para exame de necropsia. De acordo com o historico clinico o animal apresentou equimoses por todo o corpo, apatia, tosse, perda de apetite, vomitos, leucocitose, anemia, trombocitopenia, anemia hemolitica e nos exames bioquimicos apresentou fosfatase alcalina aumentada. Durante o exame de necropsia foi observado mucosas oral, ocular e vaginal ictericas, esplenomegalia com areas esbranquicadas multifocais, hepatomegalia com coloracao amarronzada, estomago com areas focalmente externa avermelhadas com sangue digerido proximo a piloro, rim apresentando coloracao amarelada difusa e com estriacoes avermelhadas em cortical e pulmao com coloracao vermelha escura. No exame histologico observou se no figado, baco, pulmao, rins, linfonodos mesentericos e coracao infiltrado inflamatorio linfoplasmocitario difuso acentuado e multiplos macrofagos apresentando em seu interior estruturas compativeis com a forma amastigota de Leishmania sp. Tendo em vista estas alteracoes clinicas, macroscopicas e microscopicas sendo compativeis como em outros casos de LVC descritos na literatura, possibilitou o diagnostico. Por tratar se de uma zoonose, cujo a taxa de letalidade pode alcancar 10% em humanos, quando nao tratada de forma correta. Casos esporadicos de LVC servem para alertar os clinicos da importancia desta enfermidade. No qual caes sao reservatorios domesticos e fundamentais na manutencao do ciclo da doenca. Em 2007 a secretaria de estado de saude de Mato Grosso recebeu confirmacao de 19 casos de leishmaniose visceral no estado, tres casos resultaram em obito, um em Rondonopolis e dois em Cuiaba. Palavras chaves: Leishmania patologia, zoonose
Predicting the number of reported and unreported cases for the COVID 19 epidemics in China, South Korea, Italy, France, Germany and United Kingdom
Venue: Journal of Theoretical Biology
Year: 2020

We model the COVID 19 coronavirus epidemics in China, South Korea, Italy, France, Germany and the United Kingdom. We identify the early phase of the epidemics, when the number of cases grows exponentially, before government implementation of major control measures. We identify the next phase of the epidemics, when these social measures result in a time dependent exponentially decreasing number of cases. We use reported case data, both asymptomatic and symptomatic, to model the transmission dynamics. We also incorporate into the transmission dynamics unreported cases. We construct our models with comprehensive consideration of the identification of model parameters. A key feature of our model is the evaluation of the timing and magnitude of implementation of major public policies restricting social movement. We project forward in time the development of the epidemics in these countries based on our model analysis.
mclust Version 4 for R Normal Mixture Modeling for Model Based Clustering Classification and Density Estimation
Year: 2012

mclust is a contributed R package for model based clustering, classification, and density estimation based on finite normal mixture modeling. It provides functions for parameter estimation via the EM algorithm for normal mixture models with a variety of covariance structures, and functions for simulation from these models. Also included are functions that combine model based hierarchical clustering, EM for mixture estimation and the Bayesian Information Criterion (BIC) in comprehensive strategies for clustering, density estimation and discriminant analysis. There is additional functionality for displaying and visualizing the models along with clustering, classification, and density estimation results. Several features of the software have been changed in this version, in particular the functionality for discriminant analysis and density estimation has been largely expanded. mclust is licensed under the GPL and distributed through CRAN; see http:/cran.r project.org/web/packages/mclust/index.html.
Multi Modal Motion Activation for Robot Control Using Spiking Neurons
Venue: 2018 7th IEEE International Conference on Biomedical Robotics and Biomechatronics (Biorob)
Year: 2018

Robot control is an active field of research, in particular for humanoid robots which present challenging problems. Yet, few of the proposed methods exhibit properties of biological systems. Neurorobotics presents an interesting approach by using neural models and mechanisms of brain function to control robots. In this paper, we present a novel way to activate robot motions with different modalities, inspired by biology and implemented with spiking neurons. We focus on two specific characteristics of biological systems for motion control: the hierarchical representation, which is distributed in the body and the nervous system, and the different activation modalities. We modeled three different activation modalities: voluntary, rhythmic and reflexes. In our architecture, motions are represented with motor primitives that can be combined and parameterized. A mechanism to learn new motions based on previous knowledge is incorporated using an error function. Our approach is evaluated controlling a robotic arm in simulation. We show that each activation modality works, and we show that they can be combined in various ways in different scenarios.