nils-herrmann/clean_scirepeval huggingface dataset:
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers
Venue: Breast Cancer Research
Year: 2014

IntroductionMore than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers.MethodsWe used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER) progesterone receptor (PR) human epidermal growth factor receptor 2 (HER2) and triple negative (TN) status; morphologic subtypes; histological grade; and nodal involvement.ResultsThe estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER positive BC in BRCA1 carriers were more consistent with the ER positive associations in the general population (intraclass correlation (ICC) 0.61, 95% confidence interval (CI) 0.45 to 0.74) and the same was true when considering ER negative associations in both groups (ICC 0.59, 95% CI: 0.42 to 0.72) Similarly, there was strong correlation between the ER positive associations for BRCA1 and BRCA2 carriers (ICC 0.67, 95% CI: 0.52 to 0.78) whereas ER positive associations in any one of the groups were generally inconsistent with ER negative associations in any of the others. After stratifying by ER status in mutation carriers, additional significant associations were observed. Several previously unreported variants exhibited associations at P <10 6 in the analyses by PR status, HER2 status, TN phenotype, morphologic subtypes, histological grade and nodal involvement.ConclusionsDifferences in associations of common BC susceptibility alleles between BRCA1 and BRCA2 carriers and the general population are explained to a large extent by differences in the prevalence of ER positive and ER negative tumors. Estimates of the risks associated with these variants based on population based studies are likely to be applicable to mutation carriers after taking ER status into account, which has implications for risk prediction.
PENGARUH KINERJA LINGKUNGAN DAN PENGUNGKAPAN TANGGUNG JAWAB SOSIAL PERUSAHAAN TERHADAP KINERJA KEUANGAN PERUSAHAAN (Studi Empiris pada Perusahaan yang Terdaftar di Bursa Efek Indonesia Periode 2011 2015)
Year: 2017

Tujuan dari penelitian ini adalah untuk memberikan bukti empiris pengaruh kinerja lingkungan dan pengungkapan tanggung jawab sosial perusahaan terhadap kinerja keuangan perusahaan. Penelitian ini juga menggunakan variabel kontrol yaitu laba per saham, rasio lancar, rasio utang. Sampel yang digunakan dalam penelitian ini sebanyak 13 perusahaan. Pemilihan Sampel menggunakan metode purposive sampling, dengan kriteria perusahaan yang terdaftar dalam Bursa Efek Indonesia dan mengikuti program PROPER, serta menerbitkan laporan keberlanjutan pada tahun 2011 2015. Penelitian ini menggunakan analisis regresi berganda. Hasil penelitian menunjukkan bahwa kinerja lingkungan perusahaan memiliki pengaruh signifikan terhadap kinerja Tobin's Q tetapi tidak memiliki pengaruh signifikan terhadap ROA, sedangkan pengungkapan tanggung jawab sosial perusahaan tidak memiliki pengaruh signifikan terhadap ROA maupun Tobin's Q.
I KERAGAMAN, HERITABILITAS DAN KORELASI GENOTIPIK JAGUNG KULTIVAR LOKAL KEBO HASIL SELEKSI MASSA DALAM SYSTEM TANAM TUMPANGSARI
Year: 2018

Penelitian ini bertujuan untuk mengetahui keragaman tanaman setelah diseleksi, heritabilitas dalam arti luas dan korelasi genotipik antar hasil dengan sifat sifat lain. Penelitian dirancang dengan Rancangan Acak Kelompok dalam lima perlakuan populasi jagung kultivar local Kebodan varietas unggul Gumarang sebagai pembanding. Data dianalisis dengan analisis keragaman pada taraf nyata 5 dan fenotipe, heritabilitas dan korelasi geotipik. Hasil penelitian menunjukkan bahwa populasi jagung kultivar local Kebo masih menunjukkan keragaman yang tinggi sehingga belum dapatdilepas sebagai varietas unggul.Semua sifat memiliki nilai heritabilitas dalam arti luas yang tinggi kecuali diameter tongkol (sedang) dan berat biji pipil kering per tongkol (rendah) Jumlah daun, panjang tongkol dan diameter tongkol memiliki korelasi genetik yang positif nyata terhadap berat biji pipil kering per tongkol. Kacang tanah yang ditanam pada populasi jagung kultivar local kebo hasil seleksi massa menunjukkan pertumbuhan dan hasil yang lebih baik dan berbeda nyata dengan kacang tanah yang ditanam pada varietas Gumarang.
An integrated data driven computational pipeline with model order reduction for industrial and applied mathematics
Year: 2018

In this work we present an integrated computational pipeline involving several model order reduction techniques for industrial and applied mathematics, as emerging technology for product and/or process design procedures. Its data driven nature and its modularity allow an easy integration into existing pipelines. We describe a complete optimization framework with automated geometrical parameterization, reduction of the dimension of the parameter space, and non intrusive model order reduction such as dynamic mode decomposition and proper orthogonal decomposition with interpolation. Moreover several industrial examples are illustrated.
The Academy of the European Federation of Clinical Chemistry and Laboratory Medicine and the European Register of Specialists in Laboratory Medicine: guide to the Academy and the Register, version 4 2020
Venue: Clinical chemistry and laboratory medicine
Year: 2020

Medicine describes the transfer of the register to the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) in 2016, the extension in 2018 of the Register beyond the European Union to Europe and the benefits of membership of the EFLM Academy to which the Register transferred on the Academy's launch in 2019. The Academy offers EuSpLM registrants access to benefits that include reduced registration rates at selected conferences and free subscription to Clinical Chemistry and Laboratory Medicine. With effect from 2020 eligibility was extended to anyone with an interest in laboratory medicine. The updated guide describes the electronically driven processes for individual membership and block enrolment from national societies/organisations, and the stepping stones to recognition as an EuSpLM within the Academy. Whilst eligibility for recognition as an EuSpLM remains largely unchanged new expectations across Europe in education, training, professional regulation and qualifications are reflected in updated criteria. The continuing driver for establishing the Academy and growing the EFLM Register reflects the federation's leadership role in the harmonisation of high quality education and training for those with an interest in laboratory medicine as well as ongoing initiatives to establish a Common Training Framework for Specialists in Laboratory Medicine under EU Directive 2013/55/EC (The Recognition of Professional Qualifications)
Queenship, Power, and Elizabethan Mentalities in Shakespeare's Histories
Year: 2013

The paper looks at the way in which the notion of queenship in connection or in contrast with that of kingship and royalty in general is reflected in Shakespeare's historical tetralogies and in Henry VIII. It is argued that all royal figures, male and female, featured in these plays, are presented by Shakespeare in accordance not only with Tudor historiography, but also with Elizabeth I's own strategies of self representation. Thus, the major notions to be looked into are virtue, legitimacy, agency, as well as, more generally, early modern religious and political issues concerning gender relations
Prevalence of Frailty and Evaluation of Associated Variables Among COPD Patients
Venue: International journal of chronic obstructive pulmonary disease
Year: 2020

Frailty in chronic obstructive pulmonary disease (COPD) patients has been associated with a higher rate of incidents, longer duration of hospitalization, poorer quality of life, and higher mortality.  To measure the prevalence of frailty among COPD patients and to evaluate associated variables.  A cross sectional study. Subjects who visited a State Center for High Cost Medicines to obtain free monthly COPD medicines were considered eligible. Individuals =40 years old who had a FEV1/FVC ratio of <0.7 post bronchodilation were enrolled. The Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale, Medical Research Council dyspnea scale (MRC) COPD Assessment Test (CAT) a combination of CAT/MRC (CAT/8)+MRC] and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity scale were used to evaluate the enrolled subjects. Variables associated with frailty were analyzed using an ordered logistic regression and a multivariate logistic regression.  The prevalence of frailty and pre frailty among the 153 COPD subjects enrolled was 50.3% (77/153) and 35.3% (54/153) respectively. Frailty scores were correlated with CAT (correlation coefficient [cc] 0.52, p <0.001) and MRC (cc: 0.48, p <0.001) Ordinal regression models showed that MRC and CAT were associated with fragility (p <0.0001 for both models) Higher odds of frailty were observed in GOLD groups B (p 0.04) and D (p 0.02) Multiple logistic regression revealed that the combination CAT/MRC>=5.5 was associated with frailty (OR 6.73; p <0.0001) and had a specificity of 80.3% sensitivity of 62.3% and positive and negative predictive values of 76.2% and67.8% respectively.  Frailty prevalence was high and was correlated with higher MRC and CAT scores. The CAT/MRC combination (CAT/8)+MRC] =5.5 was highly associated with frailty, suggesting that an additional specific evaluation for the presence of frailty is indicated.
Wi Fi Fingerprint Based Indoor Positioning: Recent Advances and Comparisons
Venue: IEEE Communications Surveys Tutorials
Year: 2016

The growing commercial interest in indoor location based services (ILBS) has spurred recent development of many indoor positioning techniques. Due to the absence of Global Positioning System (GPS) signal, many other signals have been proposed for indoor usage. Among them, Wi Fi (802.11) emerges as a promising one due to the pervasive deployment of wireless LANs (WLANs) In particular, Wi Fi fingerprinting has been attracting much attention recently because it does not require line of sight measurement of access points (APs) and achieves high applicability in complex indoor environment. This survey overviews recent advances on two major areas of Wi Fi fingerprint localization: advanced localization techniques and efficient system deployment. Regarding advanced techniques to localize users, we present how to make use of temporal or spatial signal patterns, user collaboration, and motion sensors. Regarding efficient system deployment, we discuss recent advances on reducing offline labor intensive survey, adapting to fingerprint changes, calibrating heterogeneous devices for signal collection, and achieving energy efficiency for smartphones. We study and compare the approaches through our deployment experiences, and discuss some future directions.
Composites a matrice titane et renforts TiB elabores par metallurgie des poudres cinetique de transformations des phases, formation des microstructures et proprietes mecaniques
Year: 2016

Les travaux realises dans cette these visent d'une part, a comprendre les evolutions structurales et microstructurales d'un composite a matrice titane et a renforts TiB au cours des differentes etapes d'elaboration par metallurgie des poudres et des traitements thermiques associes, et d'autre part, a etablir des relations entre microstructures et proprietes mecaniques pour ce materiau. Les cinetiques de transformations des phases de la matrice et du renfort ont ete caracterisees par DRX haute energie in situ, au cours des differents traitements du cycle de fabrication. Des analyses de la microstructure par MEB, MEB EBSD et MET (EDX et EELS) completent l'analyse par DRX. Il a ete montre que les cinetiques de transformation de la matrice des composites sont fortement affectees (decalage d'environ 300degC vers les hautes temperatures de la temperature de transus s) par le procede de fabrication. Ce decalage a ete associe a un enrichissement en elements interstitiels du au broyage mecanique des poudres et aux interstitiels presents dans les renforts TiB2 introduits pour former le TiB. L'etude in situ a aussi precise la sequence de transformation du diborure de titane en borure TiB B27 via la formation de la phase metastable TiB Bf. Les analyses par MEB et MET ont permis d'atteindre et de discuter des evolutions morphologiques et spatiales des phases (matrice et borures) au cours des differents traitements, et de caracteriser la composition chimique des borures. Une sequence de transformation du renfort est proposee. Enfin, des materiaux composites ont ete elabores et soumis a divers traitements thermomecaniques. Le lien entre les proprietes mecaniques statiques et les evolutions morphologiques des borures et de la matrice, comme de la texture des phases, a ete aborde. Des traitements ont ete proposes pour atteindre des proprietes optimales
Image retrieval: Ideas, influences, and trends of the new age
Venue: CSUR
Year: 2008

We have witnessed great interest and a wealth of promise in content based image retrieval as an emerging technology. While the last decade laid foundation to such promise, it also paved the way for a large number of new techniques and systems, got many new people involved, and triggered stronger association of weakly related fields. In this article, we survey almost 300 key theoretical and empirical contributions in the current decade related to image retrieval and automatic image annotation, and in the process discuss the spawning of related subfields. We also discuss significant challenges involved in the adaptation of existing image retrieval techniques to build systems that can be useful in the real world. In retrospect of what has been achieved so far, we also conjecture what the future may hold for image retrieval research.
The Impact of Personal Attributes on Corporate Insider Trading
Year: 2014

We analyze the importance of personal attributes in explaining the performance of reported share transactions by corporate insiders. While prior literature has focused on observable firm and trade characteristics, little effort has been made to understand how individual attributes, such as skills, abilities, or personality, impact upon post trade abnormal returns. We document that personal attributes explain up to a third of the variability in insider trading performance and dominate unobservable and observable firm and trade characteristics by a sizeable margin. Personal attributes are correlated with the insider's year of birth, education and gender, and matter more in companies with greater information asymmetry and when outsiders are inattentive to public information. We shed also new light on the significance of executive hierarchy and regulations in explaining insider trading performance and highlight the importance of controlling for individual fixed effects in insider trading research to avoid omitted variable bias in estimated regression coefficients.
BayesSim: adaptive domain randomization via probabilistic inference for robotics simulators
Venue: Robotics: Science and Systems
Year: 2019

We introduce BayesSim, a framework for robotics simulations allowing a full Bayesian treatment for the parameters of the simulator. As simulators become more sophisticated and able to represent the dynamics more accurately, fundamental problems in robotics such as motion planning and perception can be solved in simulation and solutions transferred to the physical robot. However, even the most complex simulator might still not be able to represent reality in all its details either due to inaccurate parametrization or simplistic assumptions in the dynamic models. BayesSim provides a principled framework to reason about the uncertainty of simulation parameters. Given a black box simulator (or generative model) that outputs trajectories of state and action pairs from unknown simulation parameters, followed by trajectories obtained with a physical robot, we develop a likelihood free inference method that computes the posterior distribution of simulation parameters. This posterior can then be used in problems where Sim2Real is critical, for example in policy search. We compare the performance of BayesSim in obtaining accurate posteriors in a number of classical control and robotics problems. Results show that the posterior computed from BayesSim can be used for domain randomization outperforming alternative methods that randomize based on uniform priors.
Leisure Noise Exposure and Associated Health Risk Behavior in Adolescents: An Explanatory Study among Two Different Educational Programs in Flanders
Venue: International journal of environmental research and public health
Year: 2021

Adolescents frequently engage in noisy leisure activities which can result in hearing related problems. However, the effect of leisure noise exposure is liable to an individual's risk taking behavior. Identifying leisure noise activities and relevant factors related to risk taking behavior in adolescents, are important to optimize hearing conservation programs targeting youngsters. The purpose of the study was to explore the presence of hearing related symptoms, as well as noise exposure during various activities, and the use of hearing protector devices (HPDs) in adolescents in two educational programs in Flanders. In addition, their attitudes and beliefs towards noise, hearing loss, and HPDs were investigated. The final sample consisted of 247 adolescents. The most important hearing related symptoms after noise exposure were tinnitus and noise sensitivity. With regard to leisure noise exposure, listening to PMPs was most frequently reported. The use of HPDs during most noisy activities was limited, in accordance with the presence of hearing related symptoms, considering noise as unproblematic, and having worse scores on subscales of the beliefs about hearing protection and hearing loss scale. In the future, hearing conservation programs should target adolescents specifically for a more health orientated behavior towards noise exposure, hearing loss, and HPDs.
Alternating Optimization for MIMO Secrecy Channel with a Cooperative Jammer
Venue: 2015 IEEE 81st Vehicular Technology Conference (VTC Spring)
Year: 2015

This paper proposes an alternating optimization algorithm for addressing the secrecy rate optimization problem for a multi input multi output (MIMO) secrecy channel in the presence of a multiantenna eavesdropper, where a multiantenna cooperative jammer will be employed to confuse the eavesdropper by introducing jamming signal. We investigate the secrecy rate maximization problem, which is a non convex problem in terms of transmit covariance matrices of the legitimate transmitter and the cooperative jammer. In order to circumvent this issue, we develop an optimization algorithm by alternating optimizing the transmit covariance matrices of the legitimate transmitter and the cooperative jammer where each transmit covariance matrix is optimized while other is fixed. Based on this algorithm, we develop a robust scheme by incorporating channel uncertainties associated with the eavesdropper. By exploiting S Procedure, we show that these robust optimization problems can be formulated into semidefinite programming (SDP) Simulation results have been provided to validate the convergence and the performance of the alternating algorithm.
Antioxidant defense system in young olive plants against drought stress and mitigation of adverse effects through external application of alleviating products
Year: 2020

Two years old "Koroneiki" olive trees were subjected to drought stress after foliar application of products with known ameliorating function, i.e. glycine betaine (GB) kaolin clay particles (KL) and 5 hydroxybenzimidazole (Ambiol) Measurements were taken after product application, within the stress period and after re watering. Lipid peroxidation and electrolyte leakage, as well as antioxidant defence factors (enzymes such as catalase (CAT) ascorbate peroxidase (APX) superoxide dismutase (SOD) guaiacol peroxidase (POD) glutathione reductase (GR) and phenolic compounds and ascorbic acid) were assayed. Drought induced a significant increase of lipid peroxidation and an elevation of the activity of SOD, POD and APX, while a drastic rise of oleuropein was also determined. KL application resulted in increased total phenol concentration as well as an increased activity of SOD, POD under drought. GB application increased the concentration of total flavanols during the drought period while right after application a sharp increase of oleuropein concentration was detected. Ambiol application decreased the total phenol concentration during the stress period, but enhanced POD and APX activity and total ascorbic acid concentration. During the relief period few significant differences were determined. All products alleviated to some degree the stress imposed by water deprivation, with Ambiol and KL being more efficient in preventing oxidative damage of olive trees. Based on the present results it could be assumed, that the combined use of alleviating products with different mode of action, could trigger multiple defence mechanisms, resulting in more efficient mitigation of abiotic stress.
Comparison of Sporormiella dung fungal spores and oribatid mites as indicators of large herbivore presence: evidence from the Cuzco region of Peru
Venue: Journal of Archaeological Science
Year: 2019

The ability of sedimentary proxies (especially dung fungal spores) to reflect the past presence and density of large herbivores on a landscape has been receiving increasing scrutiny. Here we examine the Sporormiella spore record from a well dated, multi proxy, highly organic sedimentary record from the small lake basin of Marcacocha in the Cuzco region of Peru. The basin, a wetland since ca. AD 1840, existed as a small lake for at least 4000 years prior. Previous work at Marcacocha has shown that changes in herbivore densities reflect the abundances of oribatid mites preserved in the lake sediments. This study tests the assumption that both the Sporormiella and the oribatid mite records responded in broadly the same way to changes in herbivore densities over the past 1200 years. Analysis reveals a very low covariance between concentrations of Sporormiella spores and the two major components of the oribatid mite assemblage: a single aquatic species of Hydrozetes and a less abundant, wider grouping comprising members of the mostly terrestrial superfamily Ceratozetoidea (referred to as the 'ceratozetoids' Variations in the Hydrozetes assemblage clearly dovetail with known historical events, including the massive decline of indigenous and camelid populations following the collapse of the Inca Empire in the mid sixteenth century. Comparison with other environmental proxies from the Marcacocha sequence, including diatoms and charophyte oospores, suggests that the ceratozetoids appear to reflect increasing terrestrialization. In contrast, although the Sporormiella record indicates the presence of livestock, it fails to register the major historical changes in herbivore presence, though reflects well episodes of lake level lowering. In small lake settings, therefore, the use of Sporormiella to estimate the density of herbivores in the catchment might be considered a relatively blunt instrument when compared with some other indicators.