nils-herrmann/clean_scirepeval huggingface dataset:
What changes when? The course of improvement during a stage based treatment for suicidal and self injuring women with borderline personality disorder and PTSD
Venue: Psychotherapy research journal of the Society for Psychotherapy Research
Year: 2018

Dialectical Behavior Therapy (DBT) with the DBT Prolonged Exposure (DBT PE) protocol is an integrated treatment for suicidal and self injuring individuals with PTSD and borderline personality disorder (BPD) that occurs in three stages: Stage 1 targets behavioral dyscontrol, Stage 2 targets posttraumatic stress disorder (PTSD) via the DBT PE protocol, and Stage 3 addresses remaining problems. We evaluated the course of change in multiple outcomes across these three stages and compared them to changes found in DBT alone.  Participants were 38 women with BPD, PTSD and recent suicidal and/or non suicidal self injury. Data were collected weekly or bi weekly to assess PTSD, BPD, global well being, state dissociation, and urges to engage in problem behaviors.  In DBT DBT PE, there was a significant improvement in PTSD in Stage 2 and in PTSD, BPD, and state dissociation in Stage 3. Compared to DBT, DBT DBT PE led to significantly higher global well being and moderately, but non significantly, lower PTSD and BPD in Stages 2 and/or 3.  PTSD does not improve until it is directly targeted and changes in other comorbid problems occur after PTSD is treated. Adding the DBT PE protocol to DBT was associated with improvement rather than worsening of outcomes.
Superconducting Circuits for Quantum Information: An Outlook
Venue: Science
Year: 2013

The performance of superconducting qubits has improved by several orders of magnitude in the past decade. These circuits benefit from the robustness of superconductivity and the Josephson effect, and at present they have not encountered any hard physical limits. However, building an error corrected information processor with many such qubits will require solving specific architecture problems that constitute a new field of research. For the first time, physicists will have to master quantum error correction to design and operate complex active systems that are dissipative in nature, yet remain coherent indefinitely. We offer a view on some directions for the field and speculate on its future.
O discurso publicitario que incita o medo e a supersticao
Venue: Media Jornalismo
Year: 2019

O ato de pensar e criar estrategias para marcas origina inumeras discussoes sobre a sociedade de consumo. Neste artigo, que tem como objeto de estudo o discurso publicitario, procuramos refletir sobre as questoes eticas e legais da publicidade que incita o medo e a supersticao. Mais especificamente, procuramos desvelar os efeitos de sentido do discurso da marca Hyundai, por meio dos pressupostos teorico metodologicos da Analise de Discurso, de linha francesa, fundada no final da decada de 1960, por Michel Pecheux. Dedicamo nos a uma analise materialista das praticas de linguagem ao trabalhar, na materialidade da lingua, articulando o materialismo, a psicanalise, a linguagem e o sujeito. O estudo reflete sobre as estrategias discursivas da marca na relacao entre desejo e consumo na sociedade capitalista, para entao pensar sobre a publicidade que e ensinada e praticada atualmente.
Propuesta de una metodologia para el desarrollo de objetos virtuales de aprendizaje. Caso de estudio: Direccion Nacional de Innovacion Academica Universidad Nacional de Colombia
Year: 2020

Esta investigacion propone una metodologia para el desarrollo de objetos virtuales de aprendizaje (OVA) que busca plantear una solucion a los problemas asociados a este tipo de desarrollos en el mercado actual. La metodologia se construyo a partir de una revision del estado del arte de metodologias existentes, que junto a un proceso de entrevista realizado a profesionales de la Direccion Nacional de Innovacion Academica (DNIA) de la Universidad Nacional de Colombia, permitio identificar un listado de caracteristicas deseables para enmarcar la metodologia propuesta en el contexto actual del desarrollo de OVAs. La metodologia cuenta con seis procesos principales: Planteamiento, Segmentacion, Produccion de Software, Produccion Audiovisual, Ensamblaje y Despliegue. De igual forma, se realizo el desarrollo de un prototipo de herramienta software para apoyar el proceso de produccion de software asociado a la metodologia propuesta. Este prototipo se construyo a partir de un analisis comparativo de herramientas de autoria de Rapid E Learning, el cual determino las caracteristicas y oportunidades de mejora que sirvieron como base para la definicion de requerimientos del mismo. Tanto la metodologia como el prototipo de herramienta fueron validados mediante su aplicacion en el desarrollo de dos objetos de responsabilidad de la DNIA, los cuales fueron construidos satisfactoriamente y recibidos a conformidad por dicha dependencia. Se valido ademas de forma cualitativa que la metodologia y prototipo de herramienta propuestos cumplieran a cabalidad con cada uno de los lineamientos que sirvieron como base para su planteamiento.
The Research Progress of L tryptophan
Year: 2014

L tryptophan has more and more application in medicine,food,feed additives and the environmental monitoring,the application status were introduced. With the increase of market demand,the application study of L tryptophan has gradually become a new hot spot. The production methods of L tryptophan,such as the enzymatic,direct fermentation,microbial reforming process were introduced. The strategy was put forward and the research prospect of L tryptophan was forecasted.
Sex Robot Matters: Slavery, the Prostituted, and the Rights of Machines
Venue: IEEE Technology and Society Magazine
Year: 2016

Why begin an article on sex robots, and the rights of machines, with an introduction to human slavery? Because these themes are more interlinked than one might imagine, but perhaps not for the reasons you would think. In this article, the author asks how a discussion about artificial intelligence (AI) and robots became fused with a discussion of slavery, rights, and objects (animate and inanimate) with these objects taking on the role of persons. These themes are brought together through a discussion of sex robots.
International Students' Perception towards Educational Tourism in the Kingdom of Bahrain
Year: 2018

Educational Tourism is any type of educational program in which travelers move to another location mainly for the purpose of gaining a learning experience in that location. This research aims to become a contribution to other previous researches conducted in the field of educational tourism to analyze the educational tourism industry in the Kingdom of Bahrain as a basis for its development to attract more international students to study in universities and higher education institutions. The research followed a quantitative methodology by distributing a survey questionnaire to one hundred international students from private universities in the Kingdom. The research adopted the random sampling technique and analyzed the data collected from those surveys statistically using mean, r value and p value figures. On the basis of research findings it is recommended that universities should improve their services provided to international students in terms of quality, speed and efficiency and to provide better facilities and more academic qualifications and degrees. Bahrain, in general, should create an educational environment that is strong enough and well reputed to attract more international students and other universities to establish their campuses in
A review of melatonin as a suitable antioxidant against myocardial ischemia reperfusion injury and clinical heart diseases
Venue: Journal of pineal research
Year: 2014

Cardiac tissue loss is one of the most important factors leading to the unsatisfactory recovery even after treatment of ischemic heart disease. Melatonin, a circadian molecule with marked antioxidant properties, protects against ischemia reperfusion (IR) injury. In particular, the myocardial protection of melatonin is substantial. We initially focus on the cardioprotective effects of melatonin in myocardial IR. These studies showed how melatonin preserves the microstructure of the cardiomyocyte and reduces myocardial IR injury. Thereafter, downstream signaling pathways of melatonin were summarized including Janus kinase 2/signal transducers and activators of transcription 3, nitric oxide synthase, and nuclear factor erythroid 2 related factor 2. Herein, we propose the clinical applications of melatonin in several ischemic heart diseases. Collectively, the information summarized in this review (based on in vitro, animal, and human studies) should serve as a comprehensive reference for the action of melatonin in cardioprotection and hopefully will contribute to the design of future experimental research.
Data Driven Storytelling
Year: 2017

This report documents the program and the outcomes of Dagstuhl Seminar 16061 "Data Driven Storytelling" Close to forty researchers and practitioners descended on Schloss Dagstuhl to forge an interdisciplinary agenda on the topic of data driven storytelling using visualization in early February, 2016. With burgeoning research interest in understanding what makes visualization effective for communication, and with practitioners pushing the envelope of the craft of visual communication, the meeting put different modes of thinking between computer science researchers and data visualization practitioners in close proximity for a week.
Teachers' talk about health, self and the student 'body'
Year: 2012

Adrienne Rich's phrase 'the personal is the political' is well worn in feminist literature. In a context where health imperatives are deeply embedded in school cultures and programming, we suggest the phrase has renewed purchase. Drawing on the testimonies of three New Zealand teachers, we explore the ways in which personal health dispositions and practices contour what and how physical and health education is envisaged in diverse school contexts and who is regarded as particularly 'at risk' of poor health outcomes. Teachers' perceptions of their students' health needs, their understanding of the role of schools in ameliorating children's health problems and the pedagogical choices made are each, we suggest, intimately linked to their lived histories of 'health' their understandings of their own and others' bodies and their personal convictions about what, for them, constitutes a 'good' and/or 'healthy' life. While the ubiquitous nature of health discourses, particularly those linked to obesity reduction, might at first blush, invoke notions of a shared agenda and a uniform commitment to improving children and young people's health, our analysis points to the diverse ways in which teachers constitute their role as health and physical educators, 'care' about students and teach health and physical education curricula.
Challenges in Cardiac and Pulmonary Sarcoidosis: JACC State of the Art Review.
Venue: Journal of the American College of Cardiology
Year: 2020

Sarcoidosis is a complex disease with heterogeneous clinical presentations that can affect virtually any organ. Although the lung is typically the most common organ involved, combined pulmonary and cardiac sarcoidosis (CS) account for most of the morbidity and mortality associated with this disease. Pulmonary sarcoidosis can be asymptomatic or result in impairment in quality of life and end stage, severe, and/or life threatening disease. The latter outcome is seen almost exclusively in those with fibrotic pulmonary sarcoidosis, which accounts for 10% to 20% of pulmonary sarcoidosis patients. CS is problematic to diagnose and may cause significant morbidity and death from heart failure or ventricular arrhythmias. The diagnosis of CS usually requires surrogate cardiac imaging biomarkers, as endomyocardial biopsy has relatively low yield, even with directed electrophysiological mapping. Treatment of CS is often multifactorial, involving a combination of antigranulomatous therapy and pharmacotherapy for cardiac arrhythmias and/or heart failure in addition to device placement and cardiac transplantation.
Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer
Venue: PLoS neglected tropical diseases
Year: 2017

Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929. These results suggest that mycolactone is a key substance in the production of nerve damage of Buruli ulcer.
Multiple Chemical Sensitivity
Year: 2013

Multiple chemical sensitivity (MCS) is a chronic polysymptomatic syndrome whose core symptom is the subjective experience of illness from low level exposures to environmental chemicals that most people find neutral or nontoxic. MCS overlaps with fibromyalgia and chronic fatigue syndrome, as well as Gulf War I Syndrome, in clinical presentation. Women in mid life constitute the majority of affected individuals. Comorbidities include rhinitis, sinusitis, bronchitis, migraine headache, irritable bowel, multiple food intolerances, arthritis, and anxiety and affective disorders. Leading proposed mechanisms for which human and animal data exist include time dependent sensitization and neurogenic inflammation. Skeptics of MCS focus on a dualistic model in which symptoms are presumed psychogenic, imagined, or misattributed. Current treatments are limited, but recent studies suggest that a pragmatic, multidisciplinary, clinical package of care including chemical avoidance, elimination diets, tolerated nutritional supplementation, and mind body interventions such as mindfulness meditation can be helpful and cost effective. Additional systematic research on MCS will facilitate better understanding of this likely heterogeneous condition with different initiating etiologies and overlapping endpoint phenomenologies.
Usage of autoencoders and Siamese networks for online handwritten signature verification
Venue: Neural Computing and Applications
Year: 2018

In this paper, we propose a novel writer independent global feature extraction framework for the task of automatic signature verification which aims to make robust systems for automatically distinguishing negative and positive samples. Our method consists of an autoencoder for modeling the sample space into a fixed length latent space and a siamese network for classifying the fixed length samples obtained from the autoencoder based on the reference samples of a subject as being genuine or forged. During our experiments, usage of attention mechanism and applying downsampling significantly improved the accuracy of the proposed framework. We evaluated our proposed framework using SigWiComp2013 Japanese and GPDSsyntheticOnLineOffLineSignature datasets. On the SigWiComp2013 Japanese dataset, we achieved 8.65% equal error rate (EER) that means 1.2% relative improvement compared to the best reported result. Furthermore, on the GPDSsyntheticOnLineOffLineSignature dataset, we achieved average EERs of 0.13% 0.12% 0.21% and 0.25% respectively, for 150, 300, 1000 and 2000 test subjects which indicate improvement in relative EER on the best reported result by 95.67% 95.26% 92.9% and 91.52% respectively. Apart from the accuracy gain, because of the nature of our proposed framework which is based on neural networks and consequently is as simple as some consecutive matrix multiplications, it has less computational cost than conventional methods such as Dynamic Time Warping and could be used concurrently on devices such as Graphics Processing Unit and Tensor Processing Unit.
Radiosterilization of Fluoroquinolones and Cephalosporins: Assessment of Radiation Damage on Antibiotics by Changes in Optical Property and Colorimetric Parameters
Venue: AAPS PharmSciTech
Year: 2008

A most common problem encountered in radiosterilization of solid drugs is discoloration or yellowing. By pharmacopoeia method, discoloration can be assessed by measuring absorbance of solutions of irradiated solid samples at 450 nm. We propose to evaluate discoloration of solid samples directly by recording their diffuse reflectance spectra. Further, the reflectance spectrum is used to compute various color parameters: CIE XYZ tristimulus value, CIE Lab, \Delta E_{\text{ab} (color difference) yellowness index (YI) dominant wavelength, and excitation purity by CIE method. The investigation of difference reflectance spectra and color parameters revealed that for fluoroquinolones, e beam was more damaging than gamma radiation, whereas for cephalosporins, trend was reversed. The quantum of discoloration with gamma radiation and e beam is found to be nearly equal when assessed by pharmacopeia method, and it is therefore inadequate to assess small color differences. The color parameters \Delta E_{\text{ab} and DYI are found to be reliable indicators of discoloration. The tolerance limits proposed in terms of /Delta E_{\text{ab} and DYI are 2 and 10 U, respectively. The dominant wavelength for all compounds has shifted to higher values indicating change in hue but defining color tolerance limit with this parameter requires adjunct excitation purity value.
Developing Embodied Conversational Agents for Coaching People in a Healthy Lifestyle: Scoping Review
Venue: Journal of medical Internet research
Year: 2020

Embodied conversational agents (ECAs) are animated computer characters that simulate face to face counseling. Owing to their capacity to establish and maintain an empathic relationship, they are deemed to be a promising tool for starting and maintaining a healthy lifestyle.  This review aimed to identify the current practices in designing and evaluating ECAs for coaching people in a healthy lifestyle and provide an overview of their efficacy (on behavioral, knowledge, and motivational parameters) and use (on usability, usage, and user satisfaction parameters)  We used the Arksey and O'Malley framework to conduct a scoping review. PsycINFO, Medical Literature Analysis and Retrieval System Online, and Scopus were searched with a combination of terms related to ECA and lifestyle. Initially, 1789 unique studies were identified; 20 studies were included.  Most often, ECAs targeted physical activity (n=16) and had the appearance of a middle aged African American woman (n=13) Multiple behavior change techniques (median=3) and theories or principles (median=3) were applied, but their interpretation and application were usually not reported. ECAs seemed to be designed for the end user rather than with the end user. Stakeholders were usually not involved. A total of 7 out of 15 studies reported better efficacy outcomes for the intervention group, and 5 out of 8 studies reported better use related outcomes, as compared with the control group.  ECAs are a promising tool for persuasive communication in the health domain. This review provided valuable insights into the current developmental processes, and it recommends the use of human centered, stakeholder inclusive design approaches, along with reporting on the design activities in a systematic and comprehensive manner. The gaps in knowledge were identified on the working mechanisms of intervention components and the right timing and frequency of coaching.
A cross platform application framework for HTML5 based e services
Venue: 2014 IEEE 11th Consumer Communications and Networking Conference (CCNC)
Year: 2014

The e service area is faced with unique challenges and opportunities as a new mobile IT landscape emerges. Technical challenges such as heterogeneous devices and networks, scalability and ability to deliver e services anytime, anywhere to the users must be met with the careful design of functional application platforms and means of distributing e services in an efficient manner. In this paper, we present a novel cross platform application framework for HTML5 based e services. We analyse the framework, applying our NIMO model for development and deployment of e Services, proving advantages concerning abstraction, availability and accessibility, as well as deployment and functionality.
The potential involvement of P2X7 receptor in COVID 19 pathogenesis: a new therapeutic target?
Venue: Scandinavian journal of immunology
Year: 2020

Coronavirus disease 2019 (COVID 19) pathogenesis remains under investigation. Growing evidence indicates the establishment of a hyperinflammatory response, characterized by sustained production of cytokines, such as IL 1b. The release and maturation of this cytokine are dependent on the activation of a catalytic multiprotein complex, known as "inflammasome" The most investigated is the NLRP3 inflammasome, which can be activated by various stimuli, such as the recognition of extracellular ATP by the P2X7 receptor. Based on the recent literature, we present evidence that supports the idea that the P2X7R/NLRP3 axis may be involved in the immune dysregulation caused by the SARS CoV 2 infection.
Affect LM: A Neural Language Model for Customizable Affective Text Generation
Venue: ACL
Year: 2017

Human verbal communication includes affective messages which are conveyed through use of emotionally colored words. There has been a lot of research effort in this direction but the problem of integrating state of the art neural language models with affective information remains an area ripe for exploration. In this paper, we propose an extension to an LSTM (Long Short Term Memory) language model for generation of conversational text, conditioned on affect categories. Our proposed model, Affect LM enables us to customize the degree of emotional content in generated sentences through an additional design parameter. Perception studies conducted using Amazon Mechanical Turk show that Affect LM can generate naturally looking emotional sentences without sacrificing grammatical correctness. Affect LM also learns affect discriminative word representations, and perplexity experiments show that additional affective information in conversational text can improve language model prediction.