nils-herrmann/clean_scirepeval huggingface dataset:
Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c Rel to reset energy metabolism in astrocytes via brain derived neurotrophic factor.
Venue: Free radical biology medicine
Year: 2018

Circadian clock genes regulate energy metabolism partly through neurotrophins in the body. The low affinity neurotrophin receptor p75NTR is a clock component directly regulated by the transcriptional factor Clock:Bmal1 complex. Brain derived neurotrophic factor (BDNF) is expressed in the brain and plays a key role in coordinating metabolic interactions between neurons and astrocytes. BDNF transduces signals through TrkB and p75NTR receptors. This review highlights a novel molecular mechanism by which BDNF via circadian control of p75NTR leads to daily resetting of glucose and glycogen metabolism in brain astrocytes to accommodate their functional interaction with neurons. Astrocytes store glycogen as an energy reservoir to provide active neurons with the glycolytic metabolite lactate. Astrocytes predominantly express the truncated receptor TrkB.T1 which lacks an intracellular receptor tyrosine kinase domain. TrkB.T1 retains the capacity to regulate cell morphology through regulation of Rho GTPases. In contrast, p75NTR mediates generation of the bioactive lipid ceramide upon stimulation with BDNF and inhibits PKA activation. As ceramide directly activates PKCz, we discuss the importance of the TrkB.T1 p75NTR ceramide PKCz signaling axis in the stimulation of glycogen and lipid synthesis and activation of RhoA. Ceramide PKCz casein kinase 2 signaling activates Nrf2 to support oxidative phosphorylation via upregulation of antioxidant enzymes. In the absence of p75NTR, TrkB.T1 functionally interacts with adenosine A2AR and dopamine D1R receptors to enhance cAMP PKA signaling and activate Rac1 and NF kB c Rel, favoring glycogen hydrolysis, gluconeogenesis and aerobic glycolysis. Thus, diurnal changes in p75NTR levels in astrocytes resets energy metabolism via BDNF to accommodate their metabolic interaction with neurons.
Anti a synuclein ASO delivered to monoamine neurons prevents a synuclein accumulation in a Parkinson's disease like mouse model and in monkeys
Venue: EBioMedicine
Year: 2020

Progressive neuronal death in monoaminergic nuclei and widespread accumulation of a synuclein are neuropathological hallmarks of Parkinson's disease (PD) Given that a synuclein may be an early mediator of the pathological cascade that ultimately leads to neurodegeneration, decreased a synuclein synthesis will abate neurotoxicity if delivered to the key affected neurons.  We used a non viral gene therapy based on a new indatraline conjugated antisense oligonucleotide (IND ASO) to disrupt the a synuclein mRNA transcription selectively in monoamine neurons of a PD like mouse model and elderly nonhuman primates. Molecular, cell biology, histological, neurochemical and behavioral assays were performed.  Intracerebroventricular and intranasal IND ASO administration for four weeks in a mouse model with AAV mediated wild type human a synuclein overexpression in dopamine neurons prevented the synthesis and accumulation of a synuclein in the connected brain regions, improving dopamine neurotransmission. Likewise, the four week IND ASO treatment led to decreased levels of endogenous a synuclein protein in the midbrain monoamine nuclei of nonhuman primates, which are affected early in PD.  The inhibition of a synuclein production in dopamine neurons and its accumulation in cortical/striatal projection areas may alleviate the early deficits of dopamine function, showing the high translational value of antisense oligonucleotides as a disease modifying therapy for PD and related synucleinopathies.
The Influence of Source Credibility Theory on Bid winning Performance
Year: 2021

Mixed crowdsourcing has become the main organization model of domestic crowdsourcing platform. The existing research on the interpretation of winning performance mainly fails to pay attention to the persuasive effect on the decision making of the contractees from the perspective of information receiving of the contractors and the credibility of the information source of the contractors. The data collected from EPWK website, the two round of data collection was carried out, including the industries engaged by the contractors, the ID of the contractor's team, the profile of the contractor's team, regional division, city level, total number of successful bids, integrity guarantee, contact authentication, ability level, professional identity, number of cases, number of members, type of the contractor's team, and number of positive evaluations. Based on the information source credibility theory, this paper constructs a model of the factors influencing the winning bid performance of the contractors from three aspects of credibility, professionalism and attractiveness, and explores the moderating effect of positive evaluation on the above relationships. The results show that good faith guarantee, contact certification, competence level and professional status positively affect the winning bid performance of the contractors, and the reverse u shaped relationship exists between the number of services and members displayed by the contractors and the winning bid performance.
Making a Case for Integrating Evidence Based Sexual Risk Reduction and Mental Health Interventions for Adolescent Girls
Venue: Issues in mental health nursing
Year: 2019

Recently identified as the top concern of teens, mental health issues now compete with sexual health risks as major threats to the well being of adolescent females. Depression and anxiety can lead to or compound the negative repercussions of sexual behavior choices that result in disproportionately high rates of sexually transmitted infections (STIs) hetero sexually acquired HIV, and unplanned pregnancy rates in girls ages 15 19. There are a limited number of CDC and DHHS recognized HIV/STI and teen pregnancy evidence based interventions (EBIs) targeted to adolescent girls of diverse races/ethnicities and none that simultaneously address common mental health disorders. The Health Improvement Project for Teens (HIPTeens) a manualized gender specific sexual risk reduction intervention, and the Creating Opportunities for Personal Empowerment (COPE) Program, a manualized cognitive behavioral skills intervention that reduces depression and anxiety, are recognized by national agencies as strong EBIs that have successfully improved their targeted outcomes. Baseline data from the HIPTeens clinical trial revealed that a substantial portion of the more than 700 girls enrolled had moderate to high levels of depressive symptoms as well as other mental health challenges (e.g. binge drinking and eating, cannabis use) Thus, there is an urgent need to combine EBIs, such as HIPTeens and COPE, to curtail these leading public health problems confronting today's adolescents.
Preparation and characterization of magnesium aluminate (MgAl2O4) spinel ceramic foams via direct foam gelcasting
Year: 2020

Lightweight MgAl2O4 spinel ceramic foams with high mechanical strength and good dielectric properties were prepared with a direct foam gelcasting method using MgAl2O4 and TiO2 (rutile phase, as sintering aid) powders. The effects of calcination temperature and foam volume on bulk density, apparent porosity, and on the mechanical and dielectric properties of the ceramic foams were investigated. Tailored porosity (75.14 82.46% pore size (10 200 mm) dielectric constant (1.66 2.05) and compressive strength (4.0 14.3 MPa) were obtained based on the change of the foam volume in the foamed slurries, and the calcination temperature of porous ceramics. The compressive strength and dielectric constant of the as manufactured spinel foam with a porosity of ~75.14% was as high as 14.3 MPa and 2.05, respectively. The spinel ceramic foam which had a porosity of 81.84% was prepared with a foam volume of 350 mL and a sintering temperature of 1500 degC, and exhibited heterogeneous pore structures, whereby large and open spherical cells involved in small circular windows on the internal walls with a mean pore size of ~66.26 mm and a grain size of ~8 mm. The experimental dielectric constant matches well with that calculated by the modified Bruggeman model. The dependence of the mechanical strength on the relative density can be represented by the Gibson and Ashby model. The fitted index values of the power relationship were 3.504 and 3.533, compared to the theoretical value of 1.5. The ceramic foam can potentially become a new type of electromagnetic wave transmitting radome material due to its low dielectric constant (1.66 2.05) and dielectric loss (0.0026 0.006) values.
A Survey of Neuromorphic Computing and Neural Networks in Hardware
Venue: ArXiv
Year: 2017

Neuromorphic computing has come to refer to a variety of brain inspired computers, devices, and models that contrast the pervasive von Neumann computer architecture. This biologically inspired approach has created highly connected synthetic neurons and synapses that can be used to model neuroscience theories as well as solve challenging machine learning problems. The promise of the technology is to create a brain like ability to learn and adapt, but the technical challenges are significant, starting with an accurate neuroscience model of how the brain works, to finding materials and engineering breakthroughs to build devices to support these models, to creating a programming framework so the systems can learn, to creating applications with brain like capabilities. In this work, we provide a comprehensive survey of the research and motivations for neuromorphic computing over its history. We begin with a 35 year review of the motivations and drivers of neuromorphic computing, then look at the major research areas of the field, which we define as neuro inspired models, algorithms and learning approaches, hardware and devices, supporting systems, and finally applications. We conclude with a broad discussion on the major research topics that need to be addressed in the coming years to see the promise of neuromorphic computing fulfilled. The goals of this work are to provide an exhaustive review of the research conducted in neuromorphic computing since the inception of the term, and to motivate further work by illuminating gaps in the field where new research is needed.
Urban parks for people in a megacity: green spaces as social places in the twenty first century Jakarta, Indonesia
Year: 2020

This thesis explores how the social experiences in urban parks and green spaces contribute to urban "conviviality" in the twenty first century city of Central Jakarta, Indonesia. Urban parks and green spaces are indispensable urban assets that help support the social sustainability of cities and potentially improve the quality of life of its citizens. Places that promote social cohesion through meaningful interactions between residents can improve the mental and physical well being of residents. In the context of Asian megacities, where pressures on the development space are high, the socio economic and cultural diversity of the population is significant, the governance and design of open green spaces, and the different ways that locals 'produce' space, is complex. The case study approach was used to examine the relationship between governance, culture and identity of places that exist in the contemporary practices of Indonesian urban context. The study area is the small but central administrative village of Menteng, located within the Special Capital Region of Jakarta Central, where the spatial segregation history as part of the Dutch city Batavia began. The case study is two locally renowned parks: Taman Menteng and Taman Suropati. Local authorities, representatives of green space organisations and the local park users constituted the study of population. Several qualitative research techniques employed during fieldwork included ethnographic observation of park users, questionnaire, focus groups and in depth interviews with park users and the different stakeholders to address how open green spaces and urban parks fit into day to day urban living in contemporary Jakarta, what events or activities (formal and informal) found in urban parks and green spaces in the city provide opportunities for meaningful interactions between urbanites, and to what extent do they provide a social platform for the city. The analysis identified several emergent themes regarding people's experiences of Taman Kota [urban parks] in Jakarta; these were sociability, everydayness, diversity, place attachment, physical quality, safety, security, accessibility, maintenance and management. Results show that despite tensions between government agencies and other stakeholders who manage these public spaces, the day to day activation of the parks by NGOs and informal economic activity does allow meaningful social interactions between different park users. Cultural (e.g. music and concerts) culinary (e.g. food vendors) and other recreational activities (e.g. sports and hobbies) are key to how these spaces function, as well as their central, accessible location and the provision of facilities that can accommodate these functions. The findings of this study impact on important implications for future practices in revealing the ways individuals negotiate and adapt to rules about park use (written and unwritten) and how diverse populations all can contribute to public conviviality.
Fault Detection, Identification and Isolation in Linear Systems via Sliding Mode Observers
Venue: 2019 4th Conference on Control and Fault Tolerant Systems (SysTol)
Year: 2019

The paper studies the fault detection, identification and isolation problems for linear control systems under the disturbances. To address the problem, sliding mode observers are used. The suggested approach for constructing sliding mode observer is based on the reduced order model of the initial system. This allows to reduce complexity of sliding mode observer and relax the conditions imposed on the initial system.
Interaction of glycyrol with calcineurin A studied by spectroscopic methods and docking
Venue: IUBMB life
Year: 2011

We have shown previously that glycyrol has an inhibitory effect on the immune response in mice by reducing calcineurin activity (Li et al. 2010, Pharm Biol 48:1177 1184) Here, we investigated the interaction of glycyrol with calcineurin A (CNA, catalytic A subunit of calcineurin) by spectroscopic methods and docking. We showed that glycyrol binds to CNA via hydrophobic interactions in a ratio of 1:1, and the main binding site is in the catalytic domain of CNA close to the calcineurin B subunit binding domain. Binding of glycyrol changes the secondary structure of CNA, and this effect may possibly inhibit CN activity.
Additive Manufacturing of Compact Manifold Microchannel Heat Exchangers Utilizing Direct Metal Laser Sintering
Venue: 2019 18th IEEE Intersociety Conference on Thermal and Thermomechanical Phenomena in Electronic Systems (ITherm)
Year: 2019

Direct Metal Laser Sintering is a metal additive manufacturing technique which uses a laser to fuse metal powders, layer by layer to form a 3D object. In this study, Direct Metal Laser Sintering is used to fabricate compact high temperature manifold microchannel heat exchangers. Compared to the state of the art heat exchangers, manifold microchannel heat exchangers have been proven to yield superior performances. However, fabrication of manifold microchannel heat exchangers using conventional fabrication methods is a challenge due to their complex geometry. Additive manufacturing processes, like Direct Metal Laser Sintering, allow fabricating the manifold microchannel heat exchanger as a single component, which significantly simplify its production process. In order to fully utilize the performance potential of manifold microchannel heat exchangers, small fins (0.1 0.2 mm) and channels (0.2 0.3 mm) are required. In this study, three different machines were used to study the effect of geometries and printing parameters, such as laser power, powder size, and layer thickness, on the fins and channel size of the fabricated microchannel heat exchangers. A comprehensive study has been performed to achieve fin thickness as small as 0.110 mm. Pressure containment tests were also performed to evaluate the minimum base thickness that can hold the designed pressure. A $3^\prime\prime}\times 3^\prime\prime}\times 3^\prime\prime} size microchannel heat exchangers was then successfully fabricated with straight fins of 0.133 mm out of Maraging Steel, and a $4^\prime\prime}\times 4^\prime\prime}\times 4^\prime\prime} size microchannel heat exchangers was successfully fabricated with fin size of 0.22mm out of Inconel 718. The results thus pave the way for more advancements in optimized additive manufacturing of next generation heat exchangers.
FB CNN: Feature Fusion Based Bilinear CNN for Classification of Fruit Fly Image
Venue: IEEE Access
Year: 2020

The high resolution devices for image capturing and the high professional requirement for users, are very complex to extract features of the fruit fly image for classification. Therefore, a bilinear CNN model based on the mid level and high level feature fusion (FB CNN) is proposed for classifying the fruit fly image. At the first step, the images of fruit fly are blurred by the Gaussian algorithm, and then the features of the fruit fly images are extracted automatically by using CNN. Afterward, the mid and high level features are selected to represent the local and global features, respectively. Then, they are jointly represented. When finished, the FB CNN model was constructed to complete the task of image classification of the fruit fly. Finally, experiments data show that the FB CNN model can effectively classify four kinds of fruit fly images. The accuracy, precision, recall, and F1 score in testing dataset are 95.00% respectively.
Exceptionally robust and conductive superhydrophobic free standing films of mesoporous carbon nanocapsule/polymer composite for multifunctional applications
Year: 2015

A novel mesoporous carbon nanocapsule (MCC)/polyvinylidene fluoride (PVDF) polymer composite based free standing film with multifunctional properties is fabricated by a facile solution approach that is appropriate for dip coating, brush on and spray applications. The MCC/PVDF composite film exhibits superhydrophobic properties with a water contact angle of approximately 160deg and a sliding angle of 5deg. The films have a high thermal stability (up to 350 degC in oxidative atmosphere) and are also electrically conductive (tunable from ~10 3 S m 1 to 10 2 S m 1) The superhydrophobicity is retained even in highly corrosive acidic and basic conditions (pH 1.29 13.54, concentrated HNO3 exposure and ammonium hydroxide solution) as well in a wide humidity range (35 83% The mesoporous carbon containers ~100 nm 1 mm size) also provide an interesting platform for encapsulating a variety of functional nanomaterials and activate release, thereby adding to the multi functionality of the superhydrophobic conductive films of exceptional environmental stability, mechanical strength ~0.1 GPa) and flexibility.
Politik Uang Dalam Pemilihan Kepala Desa (Studi Kasus Di Desa Jatirejo Kecamatan Banyakan Kabupaten Kediri)
Year: 2015

Penelitian mengenai politik uang pada pemilihan kepala desa di Desa Jatirejo Kecamatan Banyakan Kabupaten Kediri. Peneliti memiliki beberapa tujuan yaitu pertama peneliti ingin melihat dan menggambarkan bentuk bentuk praktik politik uang dalam pemilihan kepala desa. Kedua peneliti ingin melihat kesadaranagen dan menghubungkannya dengan rasionalitas agen di dalam kontestasi pemilihan kepala desa. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan studi kasus. Dalam melakukan pemilihan informan peneliti menggunakan teknik purposive dan snowball dengan menentukan informan berdasarkan kebutuhan data. Sedangkan data penelitian ini diperoleh melalui teknik observasi, wawancara dan dokumentasi. Teori strukturasi dari Anthony Giddens digunakan dalam penelitian ini sebagai alat analisis praktik politik uang dan kesadaranagen dalam kontastasi pemilihan kepala desa. Dari hasil penelitian ini dapat ditemukan bukti bahwa praktik politik uang dalam pemilihan kepala desa dilakukan oleh expert agen (kandidat calon kepala desa, tim sukses) dan lay agen yaitu pemilih selain tim sukses. Adapun cara yang dilakukan oleh agen dalam praktik politik uang yaitu melalui kegiatan kampanye. Sedangkan wujud dari politik uang sebagai sarana antara interaksi pada expert agen dan lay agen berupa uang tunai, barang dan pemberian janji janji politik seperti pembangunan infrastruktur dan ziarah wali lima. Dalam melakukan tindakan praktik politik uang maupun partisipasi dalam kontestasi pemilihan kepala desa, setiap agenmemiliki motivasi yang berbeda beda. Diantaranya yaitu motivasi atas penghargaan, motivasi atas aktualisasi diri dan motivasi atas kebutuhan sosial. Secara teoritis motivasi atas penghargaan dan aktualisasi diri termasuk dalam bentuk kesadaran diskursif, sedangkan motivasi atas kebutuhan sosial merupakan bentuk kesadaran praktis agen. Sehingga dalam penelitian ini dapat disimpulkan bahwa setiap tindakan agen dalam kontestasi pemilihan kepala desa mecerminkan motif yang mengarah pada kepentingan kepentingan individu ataupun kepentingan kelompok sebagai rasionalitas atas tindakan yang dilakukan. Kata Kunci Expert agen, Lay agen, Tindakan, Sarana antara, Kesadaran Diskursif, Kesadaran Praktis.
Preparation method of special efficient sustained release cold storage agent for supporting fruit and vegetable storage and transportation
Year: 2015

A preparation method of a special efficient sustained release cold storage agent for supporting fruit and vegetable storage and transportation comprises steps as follows: three raw materials including cyclodextrin, glycerine and sodium polyacrylate are prepared in percentage by weight; under the condition of the room temperature, cyclodextrin is added to water and is stirred until cyclodextrin is sufficiently dissolved to obtain a transparent liquid, and then glycerine is slowly added and stirred until glycerine is sufficiently dissolved; sodium polyacrylate is finally added and stirred until polyacrylate is sufficiently dissolved to obtain a colloidal liquid, and the cold storage agent is obtained; the prepared cold storage agent is packaged. The cold storage agent prepared with the method is non toxic, odorless, safe and environment friendly, has a remarkable refrigeration effect, can be recycled, cannot shrink, and cannot produce deionized water; the preparation process does not require heating, and the operation method is simple and feasible; the sustained release cold storage agent can be recycled, has low cost and good effect, is applicable to large scale production and facilitates popularization.
Quantum electronic stress: density functional theory formulation and physical manifestation.
Venue: Physical review letters
Year: 2012

The concept of quantum electronic stress (QES) is introduced and formulated within density functional theory to elucidate extrinsic electronic effects on the stress state of solids and thin films in the absence of lattice strain. A formal expression of QES (s(QE) is derived in relation to deformation potential of electronic states (Ks) and variation of electron density (Dn) s(QE) KsDn as a quantum analog of classical Hooke's law. Two distinct QES manifestations are demonstrated quantitatively by density functional theory calculations: (1) in the form of bulk stress induced by charge carriers and (2) in the form of surface stress induced by quantum confinement. Implications of QES in some physical phenomena are discussed to underlie its importance.