nils-herrmann/clean_scirepeval huggingface dataset:
Measurement and description of three dimensional shoulder range of motion with degrees of freedom interactions.
Venue: Journal of biomechanical engineering
Year: 2014

The shoulder is the most mobile joint of the human body due to bony constraint scarcity and soft tissue function unlocking several degrees of freedom (DOF) Clinical evaluation of the shoulder range of motion (RoM) is often limited to a few monoplanar measurements where each DOF varies independently. The main objective of this study was to provide a method and its experimental approach to assess shoulder 3D RoM with DOF interactions. Sixteen participants performed four series of active arm movements with maximal amplitude consisting in (1) elevations with fixed arm axial rotations (elevation series) (2) axial rotations at different elevations (rotation series) both in five planes of elevation, (3) free arm movements with the instruction to fill the largest volume in space while varying hand orientation (random series) and (4) a combination of elevation and rotation series (overall series) A motion analysis system combined with an upper limb kinematic model was used to estimate the 3D joint kinematics. Thoracohumeral Euler angles with correction were chosen to represent rotations. The angle time histories were treated altogether to analyze their 3D interaction. Then, all 3D angular poses were included into a nonconvex hull representing the RoM space accounting for DOF interactions. The effect of series of movements (n 4) on RoM volumes was tested with a one way repeated measures ANOVA followed by Bonferroni posthoc analysis. A normalized 3D RoM space was defined by including 3D poses common to a maximal number of participants into a hull of average volume. A significant effect of the series of movements (p 0.001) on the volumes of thoracohumeral RoM was found. The overall series measured the largest RoM with an average volume of 3.46 0.89 million cubic degrees. The main difference between the series of movements was due to axial rotation. A normalized RoM hull with average volume was found by encompassing arm poses common to more than 50% of the participants. In general, the results confirmed and characterized the complex 3D interaction of shoulder RoM between the DOF. The combination of elevation and rotation series (overall series) is recommended to fully evaluate shoulder RoM. The normalized 3D RoM hull is expected to provide a reliable reference to evaluate shoulder function in clinical research and for defining physiologic continuous limits in 3D shoulder computer simulation models.
An Effective Predictive Maintenance Framework for Conveyor Motors Using Dual Time Series Imaging and Convolutional Neural Network in an Industry 4.0 Environment
Venue: IEEE Access
Year: 2020

The ascent of Industry 4.0 and smart manufacturing has emphasized the use of intelligent manufacturing techniques, tools, and methods such as predictive maintenance. The predictive maintenance function facilitates the early detection of faults and errors in machinery before they reach critical stages. This study suggests the design of an experimental predictive maintenance framework, for conveyor motors, that efficiently detects a conveyor system's impairments and considerably reduces the risk of incorrect faults diagnosis in the plant; We achieve this remarkable task by developing a machine learning model that classifies whether the abnormalities observed are production threatening or not. We build a classification model using a combination of time series imaging and convolutional neural network (CNN) for better accuracy. In this research, time series represent different observations recorded from the machine over time. Our framework is designed to accommodate both univariate and multivariate time series as inputs of the model, offering more flexibility to prepare for an Industry 4.0 environment. Because multivariate time series are challenging to manipulate and visualize, we apply a feature extraction approach called principal component analysis (PCA) to reduce their dimensions to a maximum of two channels. The time series are encoded into images via the Gramian Angular Field (GAF) method and used as inputs to a CNN model. We added a parameterized rectifier linear unit (PReLU) activation function option to the CNN model to improve the performance of more extensive networks. All the features listed added together contribute to the creation of a robust future proof predictive maintenance framework. The experimental results achieved in this study show the advantages of our predictive maintenance framework over traditional classification approaches.
Electronic health records: Saudi physicians' perspective
Year: 2008

The health infrastructure of Saudi Arabia and its diagnostic, therapeutic and health prevention services have made important and increasing progress during the past decades. There is no less attention of the ICT use in health sector; however, this fold of interest did not practically reached the level of progress and advancement. In this research the aim is to explore the perception of Saudi physicians towards electronic health records (EHR) including use, attitude and challenges. A literature search related to physicians' use and perception of EHR is presented in conjunction with interviews. Physicians highlighted the value of accurate data organisation and archiving files, which facilitate better documentation of medical cases and, hence, data reading accuracy. Physicians attributed the slow spread of EHR in hospitals to the slow actions taken by hospital managers and decision makers. In conflict, IT/Record Managers believe that the successful implementation of health information technologies depends on physicians' readiness and openness, and consider gradual and not radical change. Physicians viewed the issue of EHR implementation as one of national concern and thought the adoption and implementation of the system should take a national dimension.
Notification of an adverse effect to human albumin 99MTc nanocolloid
Year: 2010

Allergic reactions to albumin nanocolloid (NA) are rare. Most of them are not potentially serious and in some cases treatment with antihistaminics may be needed. We present a case of a patient with grade II right breast ductal carcinoma, in whom a lymphoscintigraphy was performed for sentinel lymph node detection. She had a type I hypersensitivity reaction following the administration of 99mTc albumin nanocolloid, which abated spontaneously without subsequent sequels.
Soil geochemical survey in Panasqueira mine surroundings (Central Portugal) mining, metal(loid)s and related environmental impact
Year: 2013

ID# 220822 Password: 738030 Meeting: 2013 Conference of the International Medical Geology Association (25 29 August 2013) Session Type: Discipline Selection: Soils in Medical Geology Confirmation Please Check Your Abstract One More Time. Then scroll all the way down to the bottom of this page and "Conclude Submission" Page 1 of 3 18 06 2013 https:/gsa.confex.com/gsa/2013MED/dis/papers/proof.cgi?RecordType=Paper&Reco.
Open Domain Question Answering based on Text Enhanced Knowledge Graph with Hyperedge Infusion
Venue: FINDINGS
Year: 2020

The incompleteness of knowledge base (KB) is a vital factor limiting the performance of question answering (QA) This paper proposes a novel QA method by leveraging text information to enhance the incomplete KB. The model enriches the entity representation through semantic information contained in the text, and employs graph convolutional networks to update the entity status. Furthermore, to exploit the latent structural information of text, we treat the text as hyperedges connecting entities among it to complement the deficient relations in KB, and hypergraph convolutional networks are further applied to reason on the hypergraph formed text. Extensive experiments on the WebQuestionsSP benchmark with different KB settings prove the effectiveness of our model.
Self Cleaning Properties of TiN/CrN Nanoscale Multi layer Deposited on Surgical 420C Stainless Steel
Year: 2019

The present paper focuses on the investigation of self cleaning properties based on studding of water repellency and blood repellency for TiN and CrN single layer and TiN/CrN nanoscale multi layer coatings deposited via Cathodic Arc Evaporation (CAE) method on medical grade 420C stainless steel substrate. X ray diffraction (XRD) method and Field Emission Scanning Electron Microscope (FESEM) was used to characterize microstructure. Surface roughness parameters were measured by using Taylor Habsson method. Blood contact angle and water contact angle measurements test were applied to characterize the self cleaning properties of the specimens. The analysis of sample data shows that coated specimens have more water contact angle values in comparison to bare steel. Among the coated samples, CrN single layer has the highest water contact angle (80deg) due to its lower surface roughness (Ra=0.189um) among the other samples. Moreover, the findings of the paper prove that samples had inverse behavior against blood and water in the contact angle measurement test. Bare steel has higher blood contact angle (76.1deg) and more blood repellency than the coated specimens. It seems that the different behavior of samples against water and blood in contact angle tests is due to the nature of two fluids. TiN/CrN multi layer coating results had minor differences in water and blood contact angle tests (67.3deg and 62.2deg respectively)
PERILAKU KEKERASAN VERBAL FAKTOR YANG MENDORONG DAN ALTERNATIF PENGATASANNYA PADA SISWA SMPN 8 SURAKARTA
Year: 2015

Prisca Octavia. Perilaku Kekerasan Verbal, Faktor yang Mendorong dan Alternatif Pengatasannya Pada Siswa SMPN 8 Surakarta. Skripsi, Surakarta: Fakultas Keguruan dan Ilmu Pendidikan. Universitas Sebelas Maret Surakarata, Desember 2014. Penelitian ini bertujuan untuk mengetahui faktor pendorong dan alternatif pengatasan perilaku kekerasan verbal pada siswa SMPN 8 Surakarta. Penelitian ini menggunakan pendekatan kualitatif dengan jenis Penelitian Studi Kasus. Penelitian Studi Kasus merupakan penelitian yang mendalam dan membicarakan kemungkinan untuk memecahkan masalah yang aktual dengan mengumpulkan data, menyusun dan mengaplikasikan serta menginterpretasi. Subyek yang memperoleh perlakuan adalah siswa SMPN 8 Surakarta kelas VII sebanyak tiga siswa. Teknik pengumpulan data dilakukan dengan wawancara mendalam, dokumen dan observasi partisipan.Analisis data yang digunakan peneliti adalah teknikanalisis interaktif terdiri dari empat alur, yaitu pengumpulan data, reduksi data, sajian data, dan penarikan kesimpulan.
Personalizing Gastric Cancer Screening With Predictive Modeling of Disease Progression Biomarkers
Venue: Applied immunohistochemistry molecular morphology AIMM
Year: 2019

Gastric cancer (GC) remains the third most common cause of cancer related death worldwide. Infection with Helicobacter pylori is responsible for over 70% of GC incidence; colonization induces chronic inflammation, which can facilitate progression to intestinal metaplasia, dysplasia, and GC (Correa pathway) Although H. pylori eradication is a necessary first step in GC prevention, some patients continue to progress to advanced stage disease if substantial tissue damage has occurred or inflammation persists. This progression is often asymptomatic until cancer reaches stage IV, yet efficient, cost effective screening protocols for patients who present with early stages of the Correa pathway do not exist. Given the high interpatient heterogeneity in progression time through this pathway, such screening protocols must necessarily be personalized. This requires the identification of reliable and longitudinally assessable biomarkers of patient specific progression. Several gastric stem cell (GSC) markers including CD44, CD133, and Lgr5 are upregulated in GC. Here we show a significant stepwise increase in immunohistochemical staining for these markers in biopsies at different stages of the Correa pathway, suggesting GSC fraction to be a promising candidate biomarker for early detection of malignant transformation. We present a mathematical model capable of both simulating clinically observed increases in GSC fraction in longitudinal biopsy samples of individual patients, and forecasting patient specific disease progression trajectories based only on characteristics identified from immunohistochemistry at initial presentation. From these forecasts, personalized screening schedules may be identified that would allow early stratification of high risk patients, and potentially earlier detection of dysplasia or early stage GC.
SUN 122 Nuclear PDCD4 Expression Predicts Good Clinical Outcome in Luminal A Like and Luminal B Like Breast Cancer Subtypes
Venue: Journal of the Endocrine Society
Year: 2020

Hormone receptor positive (HR+ estrogen and/or progesterone receptor positive) and HER2 negative breast cancer (BC) subtype is a biologically heterogeneous entity that comprises 70% of BCs. This subtype includes both luminal (Lum) A and B like subtypes, which have differences in prognosis and sensitivity to endocrine therapies. The development of biomarkers guiding treatment decisions in these settings is required. Tumor suppressor PDCD4 (programmed cell death 4) which can be found both in the nucleus (NPDCD4) or the cytoplasm (CPDCD4) inhibits tumor growth and metastasis, and its loss is associated with poor prognosis in solid tumors. To explore the clinical relevance of PDCD4 in BC, we analyzed its expression by immunohistochemistry in a cohort of 619 patients with primary invasive BC. We found that 34.7% of patients showed NPDCD4 and 21.3% showed CPDCD4. NPDCD4 positivity, but not CPDCD4, was associated with lower clinical stage (P 0.0003) with presence of more differentiated tumors (P 6.4x10 6) and with estrogen and progesterone receptor (PR) expression (P 9.2x10 9 and P 2.8x10 9, respectively) Kaplan Meier analysis revealed that NPDCD4 expression was associated with a longer overall survival (OS) and disease free survival (DFS) in LumA like (P 0.008 and P 0.028, respectively) and LumB like (P 0.004 and P 0.012, respectively) subtypes. Interestingly, patients with LumB like tumors displaying NPDCD4 presented estimated OS and DFS rates similar to the ones observed in patients with LumA like tumors also expressing NPDCD4, indicating that its presence improves the clinical outcome of LumB like patients. Multivariate Cox regression analysis identified NPDCD4 as an independent predictor of good clinical outcome in both LumA like (HR: 0.45, 95% CI 0.22 0.96, P 0.038) and LumB like (HR: 0.28, 95% CI 0.10 0.80, P 0.018) subtypes. We validated our results by in silico analysis using expression data from the METABRIC cohort. Bioinformatics analysis of BC cells from the Cancer Cell Line Encyclopedia revealed a positive correlation between PDCD4 and PR expression (P 0.015) Since LumB like tumors present a higher risk of resistance to endocrine therapy and both PR and PDCD4 levels in this subtype are lower than in the LumA like one, we postulated that the presence of PR may modulate PDCD4 expression. Silencing of PR expression in HR+ cells decreased PDCD4 protein levels while reconstitution of PR in a PR null cell line increased them, confirming PR requirement for PDCD4 modulation. In line with PDCD4 physiological function, its knockdown increased cell migration capability of HR+ BC cells, whereas its restoration led to a decrease in cell migration of HR negative BC models. Our findings identified NPDCD4 positivity as a novel biomarker of clinical outcome in LumA and B like subtypes and revealed PDCD4 reconstitution as a novel therapeutic strategy in BC.
Microbiota Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan
Venue: Immunity
Year: 2018

&NA; Commensal microbes colonize the gut epithelia of virtually all animals and provide several benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is associated with numerous pathologies and decreased lifespan. Peptidoglycan recognition proteins (PGRPs) are important regulators of the commensal microbiota and intestinal homeostasis. Here, we found that a null mutation in Drosophila PGRP SD was associated with overgrowth of Lactobacillus plantarum in the fly gut and a shortened lifespan. L. plantarum derived lactic acid triggered the activation of the intestinal NADPH oxidase Nox and the generation of reactive oxygen species (ROS) In turn, ROS production promoted intestinal damage, increased proliferation of intestinal stem cells, and dysplasia. Nox mediated ROS production required lactate oxidation by the host intestinal lactate dehydrogenase, revealing a host commensal metabolic crosstalk that is probably broadly conserved. Our findings outline a mechanism whereby host immune dysfunction leads to commensal dysbiosis that in turn promotes age related pathologies.
In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID 19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression Analysis
Venue: Frontiers in Pharmacology
Year: 2020

The overproduction of cytokines and chemokines caused by excessive and uncontrolled inflammation contributes to the development of COVID 19. Astragaloside IV is considered as an anti inflammatory and antioxidant agent. This study aimed at undertaking a network pharmacology approach and bioinformatics analysis to uncover the pharmacological mechanisms of Astragaloside IV on COVID 19.  Potential targets of Astragaloside IV were screened from public databases. Differentially expressed genes (DEGs) in SARS CoV 2 were screened using bioinformatics analysis on the Gene Expression Omnibus (GEO) datasets GSE147507. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were subsequently performed. The overlapping genes, GO terms and KEGG pathways between Astragaloside IV targets and SARS CoV 2 DEGs were confirmed, and the location of overlapping targets in the key pathways was queried using KEGG Mapper.  A total of 425 potential targets of Astragaloside IV were screened. Besides, a total of 546 DEGs were identified between SARS CoV 2 infected samples and control samples, including 380 up regulated and 166 down regulated genes. There was a significant overlap in GO terms and KEGG pathways between Astragaloside IV targets and SARS CoV 2 DEGs. The shared genes included MMP13, NLRP3, TRIM21, GBP1, ADORA2A, PTAFR, TNF, MLNR, IL1B, NFKBIA, ADRB2, and IL6.  This study is the first to propose Astragaloside IV as a new drug candidate for alleviating hyper inflammation in COVID 19 patients. Besides, the key targets and pathways may reveal the main pharmacological mechanism of Astragaloside IV in the treatment of COVID 19.
The spatial self in schizophrenia and autism spectrum disorder
Venue: Schizophrenia Research
Year: 2017

Schizophrenia (SZ) and autism spectrum disorder (ASD) have been both described as disorders of the self. However, the manner in which the sense of self is impacted in these disorders is strikingly different. In the current review, we propose that SZ and ASD lay at opposite extremes of a particular component of the representation of self; namely, self location and the construct of peripersonal space. We evaluate emerging literature suggesting that while SZ individuals possess an extremely weak or variable bodily boundary between self and other, ASD patients possess a sharper self other boundary. Furthermore, based on recent behavioral and neural network modeling findings, we propose that multisensory training focused on either sharpening (for SZ) or making shallower (for ASD) the self other boundary may hold promise as an interventional tool in the treatment of these disorders.
Experimental study on prestressed concrete hollow slabs in service strengthened with prestressed CFRP plates
Year: 2018

Most existing studies are confined to model beam tests, which cannot reflect the actual strengthening effects provided by prestressed carbon fiber reinforced polymer (CFRP) plates to existing bridges. Hence, the actual capacity for strengthening existing bridges with prestressed CFRP plates is becoming an important concern for researchers. The paper aims to discuss these issues.  Static load tests of in service prestressed concrete hollow slabs before and after strengthening are conducted. Based on the results of the tests, the failure characteristics, failure mechanism and bending performance of the slabs are compared and analyzed. Nonlinear finite element method is also used to calculate the flexural strength of the strengthened beams prestressed with CFRP plates.  Test results show that prestressed CFRP plate strengthening technology changes the failure mode of hollow slabs, delays the development of deflection and cracks, raises cracking and ultimate load carrying capacity and remarkably improves mechanical behavior of the slab. In addition, the nonlinear finite element analyses are in good agreement with the test results.  Strengthening with prestressed CFRP plates has greater advantages compared to traditional CFRP plate strengthening technology and improves active material utilization. The presented finite element method can be applied in the flexural response calculations of strengthened beams prestressed with CFRP plates. The research results provide technical basis for maintenance and reinforcement design of existing bridges.
SEJARAH PERKEMBANGAN ILMU PADA MASA YUNANI KUNO_Rizal Purdiansyah_Oke
Year: 2013

Perkembangan ilmu pengetahuan seperti yang sekarang ini tidaklah terjadi secara spontan, melainkan secara bertahap. Setiap periode memiliki ciri khasnya sendiri terhadap perkembangan ilmu di eranya,oleh karna itu untuk le bih memahami sejarah perjalanan ilmu maka dilakukanlah pembagian atau klasifikasi secara pe iodik, dan pada kesempatan kali ini akan kita ulas mengenai perkembangan ilmu pada masa yunani kuno. Periode Yunani kuno adalah cikal bakal dari berkemb angnya ilmu pengetahuan modern seperti saat ini.Yang paling menonjol dalam perkemb angan ilmu pada era ini adalah filsafat ,yang nantinya akan menjadi induk bagi setiap ilmu pengatahuan. Zaman Yunani kuno dipandang sebagai zaman keemasan filsafat, karena p ada masa ini orang memiliki kebebasan mengungkapkan ide ide atau pendapatnya. Bangsa Yuna ni juga tidak dapat menerima pengalaman yang didasarkan pada sikap menerima begi tu saja, melainkan menumbuhkan sikap yang senang menyelidiki sesuatu secara kritis Sikap kritis inilah yang menjadikan bangsa Yunani t ampil sebagai ahli pikir ahli pikir terkenal sepanjang masa. Pada masa ini Filsafat leb ih b rcorak "kosmosentris" artinya para filsuf pada waktu itu mengarahkan perhatian mereka terhadap masalah masalah yang berkaitan dengan asal mula terjadinya alam semesta. Mereka berupaya mencari jawaban tentang prinsip pertama (arkhe) dari alam semesta, oleh karena itu mereka lebih dikenal dengan julukan "Filsuf Filsuf Alam" Selain berkembangnya filsafat,pemikiran dari tokoht koh besar seperti Arestoteles,plato,herodotus dan lain lain telah mel ahirkan berbagai disiplin ilmu yang lain seperti ilmu komunikasi dan ilmu politik