nils-herrmann/clean_scirepeval huggingface dataset:
Hemolyse au cours de l'hemoglobinose homozygote CC Etude d'une cohorte de 90 patients colliges au CHU campus de Lome (Togo)
Year: 2018

Objectifs Etudier le profil de l'hemogramme et les donnees biochimiques de l'hemolyse sur une population de patients porteurs d'hemoglobinose CC. Patients et Methode Il s'agissait d'une etude transversale descriptive faite chez 90 patients suivis au CHU Campus de Lome. les patients ont ete invites pour une consultation de suivi medicale et le dosage des differents parametres biologiques pre definis. Ont ete inclus les patients qui ont repondu a notre invitation et ont donne leur consentement. N'etaient pas inclus ceux qui avaient d'autres tares hematologiques surajoutees. Resultats L'age moyen etait de 29,4 ans 14,2. Il y avait une predominance feminine (Sex ratio H/F= 0,69) La decouverte etait fortuite dans 43% La majorite des patients (60% avaient une anemie. Le taux moyen d'hemoglobine etait de 10,8+ 1,8 g/dl. L'anemie etait en majorite microcytaire hypochrome (59% Le taux moyen d'haptoglobine etait 22,08 mg/dl 29,9 mg/dl. Il etait effondre chez 58% des patients. La valeur moyenne de la LDH etait de 226,7 U/l 122 U/l et 84% des patients avaient un taux de LDH eleve. La bilirubinemie directe moyenne etait de 8,8 mg/l 25 mg/l et 92% des patients avaient une bilirubine indirecte elevee. Ces differents parametres biochimiques etaient diversement associes en presence ou non de l'anemie hemolytique.  CC donne une hemolyse responsable d'une anemie. Nous recommandons d'identifier les facteurs attenuant l'hemolyse et d'en informer les patients. Mots cles Hemoglobinose CC, Hemolyse, Lome, Togo.
Influence of stochastic processes and catastrophic events on the reproductive dynamics of the endangered Maroon fronted Parrot Rhynchopsitta terrisi
Year: 2014

Stochastic and catastrophic events may strongly impact the dynamics of wild populations. Annual fluctuations in rainfall may affect parrot populations, but few studies address the impact of other stochastic or catastrophic events on their population dynamics. The Maroon fronted Parrot Rhynchopsitta terrisi is an endangered species that nests colonially in cavities and crevices in limestone cliffs. From 1995 to 2010, we quantified Parrot attendance at nesting colonies throughout its breeding range, and reproductive output of nesting Parrots from 1997 to 2010 at the two most important nesting colonies. There was significant variation among colonies in the number of cavities occupied by Parrots each year. Rainfall significantly influenced both the number of occupied cavities and productivity, which declined after very dry years. Natural unpredictable events such as hurricanes did not modify the nesting activity of Maroon fronted Parrots at breeding colonies. However, wildfires increased in dry years, negatively affecting attendance at breeding colonies. The Maroon fronted Parrot may overcome the impacts of climatic variability, natural stochastic processes, and human induced catastrophic events by using nesting colonies as a network of resources throughout the breeding range. Given the current trends in climate change, it is likely the species may suffer stronger and more frequent unpredictable catastrophic events, potentially putting at risk its survival in the long term.
Anonymous Attestation Using the Strong Diffie Hellman Assumption Revisited
Venue: TRUST
Year: 2016

Direct Anonymous Attestation (DAA) is a cryptographic protocol for privacy protecting authentication. It is standardized in the TPM standard and implemented in millions of chips. A variant of DAA is also used in Intel's SGX. Recently, Camenisch et al. (PKC 2016) demonstrated that existing security models for DAA do not correctly capture all security requirements, and showed a number of flaws in existing schemes based on the LRSW assumption. In this work, we identify flaws in security proofs of a number of qSDH based DAA schemes and point out that none of the proposed schemes can be proven secure in the recent model by Camenisch et al. (PKC 2016) We therefore present a new, provably secure DAA scheme that is based on the qSDH assumption. The new scheme is as efficient as the most efficient existing DAA scheme, with support for DAA extensions to signature based revocation and attributes. We rigorously prove the scheme secure in the model of Camenisch et al. which we modify to support the extensions. As a side result of independent interest, we prove that the BBS+ signature scheme is secure in the type 3 pairing setting, allowing for our scheme to be used with the most efficient pairing friendly curves.
DeepLab Based Spatial Feature Extraction for Hyperspectral Image Classification
Venue: IEEE Geoscience and Remote Sensing Letters
Year: 2019

Recently, deep learning has been used for hyperspectral image classification (HSIC) due to its powerful feature learning and classification ability. In this letter, a novel deep learning based framework based on DeepLab is proposed for HSIC. Inspired by the excellent performance of DeepLab in semantic segmentation, the proposed framework applies DeepLab to excavate spatial features of the hyperspectral image (HSI) pixel to pixel. It breaks through the limitation of patch wise feature learning in the most of existing deep learning methods used in HSIC. More importantly, it can extract features at multiple scales and effectively avoid the reduction of spatial resolution. Furthermore, to improve the HSIC performance, the spatial features extracted by DeepLab and the spectral features are fused by a weighted fusion method, then the fused features are input into support vector machine for final classification. Experimental results on two public HSI data sets demonstrate that the proposed framework outperformed the traditional methods and the existing deep learning based methods, especially for small scale classes.
Fast Consensus Using Bounded Staleness for Scalable Read Mostly Synchronization
Venue: IEEE Transactions on Parallel and Distributed Systems
Year: 2016

Reader mostly synchronization schemes, such as rwlocks and RCU, aim to maximize parallelism among readers, but many existing designs either cause readers to contend, or significantly extend writer latency, or both. This paper attributes such a problem to the lack of a fast consensus protocol between readers and writers, by which the two parts cooperate to obey the semantics of a synchronization construct. This paper describes FCP, a fast consensus protocol among readers and writers that provides scalable read side performance as well as small writer latency for TSO architectures. The heart of FCP is a version based consensus protocol between multiple non communicating readers and a pending writer. FCP leverages bounded staleness of memory consistency to avoid atomic instructions and memory barriers in readers' common paths, and uses message passing (e.g. IPI) for straggling readers so that the writer latency can be bounded. To demonstrate the effectiveness of FCP, this paper applies FCP to construct a scalable reader writers lock (rwlock) and a scalable RCU implementation. Evaluation on a 64 core machine shows that FCP significantly boosts the performance of the Linux virtual memory subsystem, a concurrent hashtable and an in memory database. Micro benchmarks show that FCP achieves smaller reader side latency and lower writer side latency when compared to state of the art rwlocks and RCU implementation.
Advances in genomic hepatocellular carcinoma research
Venue: GigaScience
Year: 2018

Hepatocellular carcinoma (HCC) is the cancer with the second highest mortality in the world due to its late presentation and limited treatment options. As such, there is an urgent need to identify novel biomarkers for early diagnosis and to develop novel therapies. The availability of next generation sequencing (NGS) data from tumors of liver cancer patients has provided us with invaluable resources to better understand HCC through the integration of data from different sources to facilitate the identification of promising biomarkers or therapeutic targets.  Here, we review key insights gleaned from more than 20 NGS studies of HCC tumor samples, comprising approximately 582 whole genomes and 1,211 whole exomes mainly from the East Asian population. Through consolidation of reported somatic mutations from multiple studies, we identified genes with different types of somatic mutations, including single nucleotide variations, insertion/deletions, structural variations, and copy number alterations as well as genes with multiple frequent viral integration. Pathway analysis showed that this curated list of somatic mutations is critically involved in cancer related pathways, viral carcinogenesis, and signaling pathways. Lastly, we addressed the future directions of HCC research as more NGS datasets become available.  Our review is a comprehensive resource for the current NGS research in HCC, consolidating published articles, potential gene candidates, and their related biological pathways.
Bending of light in novel 4D Gauss Bonnet de Sitter black holes by the Rindler Ishak method
Venue: EPL (Europhysics Letters)
Year: 2020

We study the bending of light in the space time of black holes in the four dimensional Einstein Gauss Bonnet theory of gravity, recently proposed by Glavan and Lin  (2020) 081301. Using the Rindler Ishak method, the effect of Gauss Bonnet coupling on the bending angle is studied. We show that a positive Gauss Bonnet coupling gives a negative contribution to the Schwarzschild de Sitter deflection angle, as one would expect.
Dalea EXTRACTS AS POTENTIAL INGREDIENTS FOR PHYTO FORMULATIONS: ANTIOXIDANT, ANTITYROSINASE, ANTIFUNGAL PROPERTIES AND IN VITRO CYTOTOXICITY EVALUATIONS
Year: 2019

FORMULATIONS: ANTIOXIDANT, ANTITYROSINASE, ANTIFUNGAL PROPERTIES AND IN VITRO CYTOTOXICITY EVALUATIONS Micaela Del Gaudio, Maria Daniela Santi, Jose Luis Cabrera, Mariana Andrea Peralta, Maria Gabriela Ortega* Farmacognosia, Departamento de Ciencias Farmaceuticas, Facultad de Ciencias Quimicas, Instituto Multidisciplinario de Biologia Vegetal (IMBIV CONICDET) Universidad Nacional de Cordoba, Cordoba, Argentina *gortega@fcq.unc.edu.ar
Effect of cholesterol removal on compositional and the physicochemical characteristics of anhydrous cow milk fat (cow ghee)
Year: 2019

Low cholesterol anhydrous milk fat (ghee) with 90% less cholesterol was prepared using butter as a base material and b cyclodextrin as an adsorbent. Various physicochemical properties of low cholesterol ghee such as Reichert Meissl value, Polenske value, and colour value were found to be almost unaltered by the process of cholesterol removal. However, vitamin D content reduced by 75% in low cholesterol ghee as compared to control ghee. Triglyceride profile of low cholesterol ghee was comparable to control ghee. However, total polyunsaturated fatty acids showed a slight decrease in absolute terms, i.e. 5.48% in control ghee, whereas 4.61% in low cholesterol ghee.
Mass Media Usage by Rural Youth in Agriculture in Udham Singh Nagar District of Uttarakhand
Year: 2017

Harnessing demographic dividend has become the greatest challenge before India which has aroused the demand for skilled youth especially in agriculture sector. Information technology has revolutionized Indian agriculture by opening door of enormous opportunities by playing a crucial role in scientific farming. Communication can help in motivating youthto take agriculture as a vocation by giving them right and customized information timely and location specific. The present study investigated communication behaviour of rural youth in Udham Singh Nagar District of Uttarakhand state, India. Data was collected through stratified random sampling with proportionate allocation for selecting 120 respondents for the study area. The study revealed that majority of respondents had medium level mass media exposure. Television was used mostly for entertainment, political and agricultural purpose in their own homes at night time. Majority of them were found satisfied with the information shown in the television via different agricultural programs and therefore inclined towards accepting that information. Mass media usage had a significant and positive relationship with education, innovativeness, achievement motivation, leadership ability and cosmopoliteness.The analysis of qualitative data indicated youth keenness to use information through mass media. The present study recommended that mass media infrastructure should be encouraged and utilized by rural youth in the rural areas to facilitate customized information delivery in a right time.
Design of Prefabricated Joints for HVDC XLPE Power Cables
Year: 2009

The similarity of constitutional equation in alternating current(AC) and direct current(DC) insulation suggests the similarity of structure and design principle for DC and AC cross linked polyethylene(XLPE) accessories.However,the characteristics of intrinsic parameter in the two kinds of electric field are different,which makes the design of DC XLPE accessories be different from AC XLPE accessories.Drawing lessons from AC XLPE accessories,we propose a detailed design method for the structure of DC XLPE accessories.In designing DC XLPE joints,the suppression of interfacial space charge is the most important,which depends on the reasonable permittivity and conductivity coordination of the two insulations.Finally,by taking the joint's design of 30 kV DC XLPE cable as an example,the conductivity ratio which meets the design requirements for optimization of stress cone is proposed from the result of simulation.
Sensory Substitution and the Neural Correlates of Navigation in Blindness
Year: 2018

This chapter reviews the most recent advances in sensory substitution and the neural correlates of navigation in congenital blindness Studies have established the superior ability of congenitally blind (CB) participants with the aid of Sensory Substitution Devices (SSDs) to navigate new environments and detect the size and shape of obstacles in order to avoid them. These studies suggest that with training, CB can achieve a representation of space that is equivalent to that of the sighted. From a phenomenological point of view, sensation and perception provided by SSDs have been likened to real vision, but the question remains as to the subjective sensations (qualia) felt by users. We review recent theories on the phenomenological properties of sensory substitution and the recent literature on spatial abilities of participants using SSDs. From these different sources of research, we conclude that training induced plastic changes enable task specific brain activations. The recruitment of the primary visual cortex by nonvisual SSD stimulations and, the subsequent activations of associative visual cortices in the congenitally blind, suggest that the sensory information is treated in an amodal fashion; i.e. in terms of the task being performed rather than the sensory modality. These anatomical changes enable the embodiment of nonvisual information allowing SSD users to accomplish a multitude of "visual" tasks. We will emphasize here the abilities of CB individuals to navigate in real and virtual environments in spite of a large volumetric reduction in the posterior segment of the hippocampus a key area involved in navigation In addition, the superior behavioral performance of CB in a variety of sensory and cognitive tasks, combined with anatomical and functional MRI, underlines the susceptibility of the brain to training induced plasticity.
A Meta analysis of the Effects of Computer Technology on School Students' Mathematics Learning
Year: 2010

This study examines the impact of computer technology (CT) on mathematics education in K 12 classrooms through a systematic review of existing literature. A meta analysis of 85 independent effect sizes extracted from 46 primary studies involving a total of 36,793 learners indicated statistically significant positive effects of CT on mathematics achievement. In addition, several characteristics of primary studies were identified as having effects. For example, CT showed advantage in promoting mathematics achievement of elementary over secondary school students. As well, CT showed larger effects on the mathematics achievement of special need students than that of general education students, the positive effect of CT was greater when combined with a constructivist approach to teaching than with a traditional approach to teaching, and studies that used non standardized tests as measures of mathematics achievement reported larger effects of CT than studies that used standardized tests. The weighted least squares univariate and multiple regression analyses indicated that mathematics achievement could be accounted for by a few technology, implementation and learner characteristics in the studies.
Research on Small Square PCB Rogowski Coil Measuring Transient Current in the Power Electronics Devices
Venue: Sensors
Year: 2019

With the development of China's electric power, power electronics devices such as insulated gate bipolar transistors (IGBTs) have been widely used in the field of high voltages and large currents. However, the currents in these power electronic devices are transient. For example, the uneven currents and internal chip currents overshoot, which may occur when turning on and off, and could have a great impact on the device. In order to study the reliability of these power electronics devices, this paper proposes a miniature printed circuit board (PCB) Rogowski coil that measures the current of these power electronics devices without changing their internal structures, which provides a reference for the subsequent reliability of their designs.
La relacion laboral especial de los artistas en espectaculos publicos
Year: 2011

La problematica de la relacion laboral de los artistas en espectaculos publicos se aborda desde dos niveles basicos: el primero de caracter esencialmente teorico, trata de fijar los contornos y el fundamento de la relacion laboral especial objeto de estudio. El segundo, de caracter esencialmente exegetico, consiste en el analisis de la normativa reglamentaria. Los aspectos diferentes que conforman la base sobre la que se ha elaborado el analisis exegetico han sido los siguientes: 1 Su conceptuacion como relacion laboral de caracter especial 2 La determinacion de la materia social que regula 3 Analisis de la tecnica juridica empleada para su regulacion 4 Los criterios a seguirse en el analisis exegetico de la normativa reglamentaria. Asi, una vez superadas las dificultades iniciales para delimitar el contrato de trabajo especial de los artistas que intervienen en espectaculos publicos, cobra sentido abordar las distintas cuestiones que integran el regimen juridico de este contrato especial y particularmente temas tales como el ingreso en el trabajo artistico, las modalidades de contratacion, los derechos y deberes de las partes, la jornada de trabajo, las vacaciones, los permisos, las diversas formas de retribucion, etc.
A Literature Based Knowledge Graph Embedding Method for Identifying Drug RepurposingOpportunities in Rare Diseases
Venue: PSB
Year: 2020

Millions of Americans are affected by rare diseases, many of which have poor survival rates. However, the small market size of individual rare diseases, combined with the time and capital requirements of pharmaceutical R&D, have hindered the development of new drugs for these cases. A promising alternative is drug repurposing, whereby existing FDA approved drugs might be used to treat diseases different from their original indications. In order to generate drug repurposing hypotheses in a systematic and comprehensive fashion, it is essential to integrate information from across the literature of pharmacology, genetics, and pathology. To this end, we leverage a newly developed knowledge graph, the Global Network of Biomedical Relationships (GNBR) GNBR is a large, heterogeneous knowledge graph comprising drug, disease, and gene (or protein) entities linked by a small set of semantic themes derived from the abstracts of biomedical literature. We apply a knowledge graph embedding method that explicitly models the uncertainty associated with literature derived relationships and uses link prediction to generate drug repurposing hypotheses. This approach achieves high performance on a gold standard test set of known drug indications (AUROC 0.89) and is capable of generating novel repurposing hypotheses, which we independently validate using external literature sources and protein interaction networks. Finally, we demonstrate the ability of our model to produce explanations of its predictions.
Resistant starch can improve insulin sensitivity independently of the gut microbiota
Venue: Microbiome
Year: 2017

BackgroundObesity related diseases, including type 2 diabetes and cardiovascular disease, have reached epidemic proportions in industrialized nations, and dietary interventions for their prevention are therefore important. Resistant starches (RS) improve insulin sensitivity in clinical trials, but the mechanisms underlying this health benefit remain poorly understood. Because RS fermentation by the gut microbiota results in the formation of physiologically active metabolites, we chose to specifically determine the role of the gut microbiota in mediating the metabolic benefits of RS. To achieve this goal, we determined the effects of RS when added to a Western diet on host metabolism in mice with and without a microbiota.ResultsRS feeding of conventionalized mice improved insulin sensitivity and redressed some of the Western diet induced changes in microbiome composition. However, parallel experiments in germ free littermates revealed that RS mediated improvements in insulin levels also occurred in the absence of a microbiota. RS reduced gene expression of adipose tissue macrophage markers and altered cecal concentrations of several bile acids in both germ free and conventionalized mice; these effects were strongly correlated with the metabolic benefits, providing a potential microbiota independent mechanism to explain the physiological effects of RS.ConclusionsThis study demonstrated that some metabolic benefits exerted by dietary RS, especially improvements in insulin levels, occur independently of the microbiota and could involve alterations in the bile acid cycle and adipose tissue immune modulation. This work also sets a precedent for future mechanistic studies aimed at establishing the causative role of the gut microbiota in mediating the benefits of bioactive compounds and functional foods.