nils-herrmann/clean_scirepeval huggingface dataset:
Fatigue limit of polycrystalline zirconium oxide ceramics: Effect of grinding and low temperature aging.
Venue: Journal of the mechanical behavior of biomedical materials
Year: 2016

The following study aimed to evaluate the effect of grinding and low temperature aging on the fatigue limit of Y TZP ceramics for frameworks and monolithic restorations. Disc specimens from each ceramic material, Lava Frame (3M ESPE) and Zirlux FC (Ivoclar Vivadent) were manufactured according to ISO:6872 2008 and assigned in accordance with two factors: (1) "surface treatment" without treatment (as sintered, Ctrl) grinding with coarse diamond bur (181um; Grinding) and (2) "low temperature aging (LTD)" presence and absence. Grinding was performed using a contra angle handpiece under constant water cooling. LTD was simulated in an autoclave at 134degC under 2 bar pressure for 20h. Mean flexural fatigue limits (20,000 cycles) were determined under sinusoidal loading using stair case approach. For Lava ceramic, it was observed a statistical increase after grinding procedure and different behavior after LTD stimuli (Ctrl<Grinding; Ctrl<Ctrl Ltd; Grinding=Grinding Ltd) while for Zirlux, grinding and low temperature aging promoted a statistical increase in the fatigue limit (Ctrl<Grinding; Ctrl<Ctrl Ltd; Grinding<Grinding Ltd) An important increase was observed in m phase content after both stimuli (grinding and LTD) although with different intensities. Additionally, fatigue test did not promote increase of m phase content. Thus, tested grinding and low temperature aging did not damage the fatigue limit values significantly for both materials evaluated, even though those conditions promoted increase in m phase.
Selection and Clonal Propagation of High Artemisinin Genotypes of Artemisia annua
Venue: Front. Plant Sci.
Year: 2018

Artemisinin, produced in the glandular trichomes of Artemisia annua L. is a vital antimalarial drug effective against Plasmodium falciparum resistant to quinine derived medicines. Although work has progressed on the semi synthetic production of artemisinin, field production of A. annua remains the principal commercial source of the compound. Crop production of artemisia must be increased to meet the growing worldwide demand for artemisinin combination therapies (ACTs) to treat malaria. Grower artemisinin yields rely on plants generated from seeds from open pollinated parents. Although selection has considerably increased plant artemisinin concentration in the past 15 years, seed generated plants have highly variable artemisinin content that lowers artemisinin yield per hectare. Breeding efforts to produce improved F1 hybrids have been hampered by the inability to produce inbred lines due to self incompatibility. An approach combining conventional hybridization and selection with clonal propagation of superior genotypes is proposed as a means to enhance crop yield and artemisinin production. Typical seed propagated artemisia plants produce less than 1% (dry weight) artemisinin with yields below 25 kg/ha. Genotypes were identified producing high artemisinin levels of over 2% and possessing improved agronomic characteristics such as high leaf area and shoot biomass production. Field studies of clonally propagated high artemisinin plants verified enhanced plant uniformity and an estimated gross primary productivity of up to 70 kg/ha artemisinin, with a crop density of one plant m 2. Tissue culture and cutting protocols for the mass clonal propagation of A. annua were developed for shoot regeneration, rooting, acclimatization, and field cultivation. Proof of concept studies showed that both tissue culture regenerated plants and rooted cutting performed better than plants derived from seed in terms of uniformity, yield, and consistently high artemisinin content. Use of this technology to produce plants with homogeneously high artemisinin can help farmers markedly increase the artemisinin yield per cultivated area. This would lead to increased profit to farmers and decreased prices of ACT.
From demand response to integrated demand response: review and prospect of research and application
Venue: Protection and Control of Modern Power Systems
Year: 2019

In the traditional power system demand response, customers respond to electricity price or incentive and change their original power consumption pattern accordingly to gain additional benefits. With the development of multi energy systems (MES) in which electricity, heat, natural gas and other forms of energy are coupled with each other, all types of energy customers are able to participate in demand response, leading to the concept of integrated demand response (IDR) In IDR, energy consumers can response not only by reducing energy consumption or opting for off peak energy consumption but also by changing the type of the consumed energy. Taking the traditional demand response in power system as a starting point, the studies of the fundamental theory, framework design and potential estimation of demand response in power system are reviewed, and the practical cases and software development of demand response are introduced. Finally, the current theoretical research and application of IDR are assessed.
The Benefits and and Risks of Strategic Brand Collaboration
Year: 2010

This paper explains the benefits and risks of brand collaboration from a strategic perspective. It integrates the benefits and risks with co branding that previously lay scattered across poorly integrated domains. It is argued that brand managers can have three general benefits from brand collaboration functional, emotional and self expressive benefits. However, it is also argued that beyond the more obvious benefits, brand collaboration also involves risks for both the parties involved. First, there is a risk with loss of control over the brand associations; second, there is a risk with loss of control and lost focus in the target groups; third, image dilution through overexposure; fourth, a lost focus in the target group; fifth, a risk that one of the brands in the alliance becomes generic; and sixth, less leverage points for the involved brands in the future.
Design and evaluation of surface irrigation systems applying an analytical formula in the irrigation district 085, La Begona, Mexico
Venue: Agricultural Water Management
Year: 2019

The area under irrigation in Mexico is just over 6.64 million hectares, most of which is irrigated with surface gravity systems (borders or furrows) However, one of the main problems presented by these methods is the loss associated with deep infiltration, tailwaters, and flooding in some parts of the land as a result of a poor flow design at the entrance of the furrow or border. In this study, the evaluation of irrigation tests, the data of the plot and the net irrigation depth to be applied show that the optimum expense that can be put in each furrow during an irrigation event can be calculated under the hypothesis that with this expense, the historical water depths applied in the evaluated plots can be reduced. The results obtained in 250 irrigation tests in 1010 ha in the Irrigation District 085, La Begona, Guanajuato, Mexico, showed that average water depths decreased by 19 cm, irrigation time decreased 12 h ha 1 on average, and the average volume saved was 2150 m3 ha, which represented a total of 49% of the total volume used. In addition, the average efficiency rose from 51 to 86%
Multi Stakeholder Initiatives for Sustainable Development Goals: The Importance of Interlocutors
Year: 2017

This article argues that the complex multi stakeholder arrangements anticipated for implementing Sustainable Development Goals call for a distinct type of host: an interlocutor. This central idea arises from new comparative research on multi stakeholder initiatives (MSIs) undertaken in four countries: Costa Rica, Indonesia, Kenya and Kyrgyzstan. This work adds a detailed dimension to meta studies on conditions for success and practical guides for establishing and running MSIs. It begins to fill a significant gap in knowledge by analysing the attributes and competencies required for effectively orchestrating MSIs as well as illuminating their relative significance over time. The context is an anticipated expansion in demand for finely tuned and skilled hosting of Sustainable Development Goals inspired MSIs. This task will probably be more complicated than MSIs associated with climate change and Millennium Development Goals, both of which saw business on the side lines with uneven attention paid to the principle of local ownership. Recognising and investing in interlocution as a pivotal role can increase the performance of internationally inspired MSIs which, to date, have a mixed but generally poor record of effectiveness.
MicroRNA 21 targets tumor suppressor genes in invasion and metastasis
Venue: Cell Research
Year: 2008

MicroRNAs (miRNAs) are a class of naturally occurring small non coding RNAs that target protein coding mRNAs at the post transcriptional level. Our previous studies suggest that mir 21 functions as an oncogene and has a role in tumorigenesis, in part through regulation of the tumor suppressor gene tropomyosin 1 (TPM1) Given that TPM1 has been implicated in cell migration, in this study we further investigated the role of mir 21 in cell invasion and tumor metastasis. We found that suppression of mir 21 in metastatic breast cancer MDA MB 231 cells significantly reduced invasion and lung metastasis. Consistent with this, ectopic expression of TPM1 remarkably reduced cell invasion. Furthermore, we identified two additional direct mir 21 targets, programmed cell death 4 (PDCD4) and maspin, both of which have been implicated in invasion and metastasis. Like TPM1, PDCD4 and maspin also reduced invasiveness of MDA MB 231 cells. Finally, the expression of PDCD4 and maspin inversely correlated with mir 21 expression in human breast tumor specimens, indicating the potential regulation of PDCD4 and maspin by mir 21 in these tumors. Taken together, the results suggest that, as an oncogenic miRNA, mir 21 has a role not only in tumor growth but also in invasion and tumor metastasis by targeting multiple tumor/metastasis suppressor genes. Therefore, suppression of mir 21 may provide a novel approach for the treatment of advanced cancers.
Uji Efektivitas Ekstrak Etanol Biji Rambutan (Nephelium lappaceum L. sebagai Larvasida Alami pada Larva Nyamuk Aedes aegypti
Year: 2018

Metode pengendalian vektor yang sering digunakan hingga saat ini adalah larvasida sintetik temephos. Saat ini di beberapa daerah telah terjadi resistensi larva Aedes aegypti terhadap temephos, sehingga diperlukan larvasida alami sebagai alternatif. Ekstrak etanol biji rambutan (Nephelium lappaceum L. mengandung senyawa flavonoid yang bersifat racun pernafasan sehingga dapat membunuh larva Aedes aegypti. Tujuan penelitian adalah untuk mengetahui efektivitas ekstrak etanol biji rambutan sebagai larvasida terhadap larva Aedes aegypti. Jenis penelitian ini adalah eksperimental dengan rancangan Post Test Only Group Design. Populasi dalam penelitian adalah larva Aedes aegypti instar III atau IV yang diperoleh dari telur yang dikoleksi dari rumah warga di Kelurahan Jati Kecamatan Padang Timur. Data penelitian dianalisis menggunakan uji Kruskal wallis dan uji signifikansi Mann whitney, serta analisis probit untuk mendapatkan LC50 dan LC90. Hasil penelitian menunjukkan (1) konsentrasi terendah ekstrak etanol biji rambutan yang efektif membunuh larva Aedes aegypti adalah konsentrasi 4% (2) LC50 dan LC90 dari ekstrak etanol biji rambutan adalah 0,975% dan 3,473% (3) persentase kematian larva setelah dipaparkan temephos 0,012 mg/L adalah 83,75% Simpulan penelitian ini adalah ekstrak etanol biji rambutan (Nephelium lappaceum L. 4% terbukti lebih efektif dibandingkan dengan temephos 0,012 mg/L terhadap kematian larva Aedes aegypti di Kelurahan Jati, Kecamatan Padang Timur, Kota Padang.
Efisiensi Pakan dan Pertumbuhan Ikan Bawal Bintang (Trachinotus blochii) dengan penambahan enzim fitase
Year: 2019

The aim of this study to determined the exact dose of phytase enzymes to improve feed efficiency and growth of silver pompano. This research was held in February 2019 for 35 days at the Balai Perikanan Budidaya Laut (BPBL) Batam. The method was research experimental with a completely randomized design (CRD) with 4 treatments and 3 replications. Based on data analysis with One Way ANOVA and Tukey phytase enzym give effect to silver pompano and the optimal result was on treatment D with the parameters nutrient efficiency utilization (24,69+ 1.36 weight specific growth rate (5,55+ 0.36 length specific growth rate (5,89+ 0.36
Effects of pulmonary acid aspiration on the regional pulmonary blood flow within the first hour after injury: An observational study in rats.
Venue: Clinical hemorheology and microcirculation
Year: 2015

Gastric aspiration events are recognized as a major cause of pneumonitis and the development of acute respiratory distress syndrome. The first peak in the inflammatory response has been observed one hour after acid induced lung injury in rats. The spatial pulmonary blood flow (PBF) distribution after an acid aspiration event within this time frame has not been adequately studied. We determined therefore PBF pattern within the first hour after acid aspiration.  Anesthetized, spontaneous breathing rats (n 8) underwent unilateral endobronchial hydrochlorid acid instillation so that the PBF distributions between the injured and non injured lungs could be compared. The signal intensity of the lung parenchyma after injury was measured by magnetic resonance tomography. PBF distribution was determined by measuring the concentration of [68Ga] radiolabeled microspheres using positron emission tomography.  Following acid aspiration, magnetic resonance images revealed increased signal intensity in the injured regions accompanied by reduced oxygenation. PBF was increased in all injured lungs (171 [150; 196] median [25% 75% compared to the blood flow in all uninjured lungs (141 [122; 159] P 0.0078)  From the first minute until fifty minutes after acid induced acute lung injury, the PBF was consistently increased in the injured lung. These blood flow elevation was accompanied by significant hypoxemia.
The comparison of trial data based and registry data based cost effectiveness of infliximab treatment for rheumatoid arthritis in Sweden using a modeling approach.
Venue: Value in health the journal of the International Society for Pharmacoeconomics and Outcomes Research
Year: 2013

To evaluate the precision of the predictive cost effectiveness assessment based on a phase 3 clinical trial with infliximab for the treatment of rheumatoid arthritis in Swedish clinical practice.  Three patient cohorts were identified: the patients included in the infliximab trial (ATTRACT) patients initially treated with infliximab from a Swedish registry (STURE) a subset of these registry patients meeting inclusion criteria for the ATTRACT trial was the third patient cohort; two sets of assumptions in relation to the efficacy data were evaluated: "ATTRACT" (efficacy data over the duration of the trial) and "STURE" (effectiveness data over 10 years) In addition, the impact of including the placebo effect for the comparator was evaluated as a basis for the calculation of cost effectiveness by using a modeling approach. A health economic model was utilized to estimate the cost per quality adjusted life year (QALY) gained.  The results for the three patient cohorts ranged from cost saving to a cost per QALY gained of EUR2,400 and EUR24,900 to EUR26,000 when the ATTRACT and STURE assumptions were used, respectively. Sensitivity analyses indicated that the inclusion of placebo effect had the largest effect on the results, increasing the cost per QALY gained to approximately EUR50,000 for all patient cohorts.  The treatment effect of infliximab measured in clinical trials and clinical practice results in comparable cost effectiveness ratios, as calculated by using a modeling approach, whereas the assumptions made in relation to the effectiveness data and the chosen comparator have a large impact on the results. This reinforces the value of early modeling studies based on randomized clinical trial data, but assumptions made need to be carefully assessed.
Oral Health Status and Treatment Needs among Hemophilic Children in Hyderabad, Telangana, India
Venue: International journal of clinical pediatric dentistry
Year: 2019

The aim of this study is to evaluate and compare the dental caries stratus and treatment needs of hemophilic children with that of healthy and normal children.  A descriptive cross sectional study was conducted on 60 subjects with age ranging from 7 16 years attending and registering their names, residential address, parental occupation, and other criteria in Hemophilic Society at the Telangana state. The oral hygiene status was recorded by using oral hygiene index simplified (OHI S) Teeth affected by dental caries and teeth restored/extracted as sequale of dental caries were assessed using decayed, missed, filled tooth (DEFT) and DMFT for primary and permanent dentition, respectively. Statistical analysis Data were analyzed by means of SPSS, version 21.0, and the Chi square test and the Kruskal Wallis test.  The mean oral hygiene index simplified scores were 1.28 in 7 9 years and 1.87 in 13 16 years, respectively. The mean DMFT DEFT of 7 9 years was 4.76 and for 13 16 years was 3.11 highest mean DMFT DEFT 4.76 was recorded in the 7 9 years age group.  The present study showed that oral hygiene status of hemophilic children was poor and treatment requirement was high among hemophilic children. The overall prevalence of dental caries was 73.3% and the treatment needs were 93.90% How to cite this article Reddy KS, Reddy NV, et al. Oral Health Status and Treatment Needs among Hemophilic Children in Hyderabad, Telangana, India.
The impact of economic growth, energy consumption, trade openness, and financial development on carbon emissions: empirical evidence from Turkey
Venue: Environmental Science and Pollution Research
Year: 2018

This study examines the impact of economic growth, energy consumption, trade openness, financial development on carbon emissions for the case of Turkey by using annual time series data for the period of 1960 2013. The Lee and Strazicich test suggests that the variables are suitable for applying the bounds testing approach to cointegration. The cointegration analysis reveals that there exists a long run relationship between the per capita real income, per capita energy consumption, trade openness, financial development, and per capita carbon emissions in the presence of structural breaks. The results show that in the long run, carbon emissions are mainly determined by economic growth, energy consumption, trade openness, and financial development. The VECM Granger causality analysis indicates a long run unidirectional causality running from economic growth, energy consumption, trade openness, and financial development to carbon emissions. The findings also show that the EKC hypothesis is valid for Turkey both in the long run and short run. The study provides some implications for policy makers to decrease carbon emissions in Turkey.
Collision free trajectory planning of multi rotor UAVs in a wind condition based on modified potential field
Year: 2021

A multi rotor unmanned aerial vehicle (UAV) is a rotorcraft with more than two rotors to enhance payload capability and endurance. A key feature required for the use of these vehicles under complex conditions is a technique to solve the problem of trajectory planning analytically. Hence, this paper proposes an indirect solution of the optimal control problem for path planning of the hexarotor system with different cost functions under different wind loads. First, the generalized Euler Lagrange formulation is used to derive the dynamic equations of a hexarotor system. Hamiltonian function for a proper objective function is formed, then using the PMP optimality necessary conditions are obtained. Finally, in order to verify the effectiveness of the proposed approach, several simulation studies on a hexacopter are performed for finding the optimal paths at point to point motion with different objective functions like minimum effort, collision free and windy environment. Also, a novel approach for obstacle avoidance of unmanned aerial vehicle is proposed by using a modified artificial potential field which overcomes the local minima issue and finds a practical trajectory for robot path planning. The results clearly show the effectiveness of the proposed approach on the multirotor systems.
Feature Extraction to Detect Diabetic Retinopathy and Glaucoma in Fundus Image
Year: 2018

Visual impairment due to various eye related diseases can be largely prevented through regular fundus colour image screening. Large scale screening of the retinal image in the early stages is crucial to disease diagnosis. It is reported that the number of ophthalmologist ratios is very low. Hence, the computer aided screening is required where the diagnosis of disease from an image is done from the main features of the fundus image. In this work, an attempt has been made to design an algorithm to extract two features, viz. ISNT ratio and micro aneurysm which individually signifies glaucoma and diabetic retinopathy respectively. The proposed features extraction method is clinically significant and can be utilized to distinguish glaucoma and diabetic retinopathy precisely.  Fundus image, ISNT ratio, micro aneurysm, glaucoma, diabetic retinopathy Cite this Article Himanshu Kumar, Rakhi Agarwal, Shatakshi Singh. Feature Extraction to Detect Diabetic Retinopathy and Glaucoma in Fundus Image.  9 12p.
Beyond Localized Graph Neural Networks: An Attributed Motif Regularization Framework
Venue: 2020 IEEE International Conference on Data Mining (ICDM)
Year: 2020

We present InfoMotif, a new semi supervised, motif regularized, learning framework over graphs. We overcome two key limitations of message passing in popular graph neural networks (GNNs) localization (a $k$ layer GNN cannot utilize features outside the $k$ hop neighborhood of the labeled training nodes) and over smoothed (structurally indistinguishable) representations. We propose the concept of attributed structural roles of nodes based on their occurrence in different network motifs, independent of network proximity. Two nodes share attributed structural roles if they participate in topologically similar motif instances over co varying sets of attributes. Further, InfoMotif achieves architecture independence by regularizing the node representations of arbitrary GNNs via mutual information maximization. Our training curriculum dynamically prioritizes multiple motifs in the learning process without relying on distributional assumptions in the underlying graph or the learning task. We integrate three state of the art GNNs in our framework, to show significant gains (3 10% accuracy) across six diverse, real world datasets. We see stronger gains for nodes with sparse training labels and diverse attributes in local neighborhood structures.
Secure Control: Towards Survivable Cyber Physical Systems
Venue: 2008 The 28th International Conference on Distributed Computing Systems Workshops
Year: 2008

In this position paper we investigate the security of cyber physical systems. We (1) identify and define the problem of secure control, (2) investigate the defenses that information security and control theory can provide, and (3) propose a set of challenges that need to be addressed to improve the survivability of cyber physical systems.