nils-herrmann/clean_scirepeval huggingface dataset:
A Randomized Comparison of the GlideScope Videolaryngoscope to the Standard Laryngoscopy for Intubation by Pediatric Residents in Simulated Easy and Difficult Infant Airway Scenarios
Venue: Pediatric emergency care
Year: 2011

Videolaryngoscopy has been developed mainly to assist difficult airway intubation. However, there is a lack of studies demonstrating the real efficacy of its use in children. In this study, we tested the hypothesis that GlideScope (Verathon Inc, Bothell, Wash) videolaryngoscope improves tracheal intubation when used by pediatric residents in an advanced patient simulation model.  Pediatric residents who passed a pediatric advanced life support course were eligible for the study. An advanced infant simulator was used, and 4 scenarios were proposed: normal airway (NA) tongue edema (TE) tongue edema and oropharyngeal edema, and cervical collar. No participant had prior experience with any videolaryngoscope. After a brief instruction in GlideScope technique, each participant performed the 4 scenarios using both the standard Miller and GlideScope laryngoscopes, in a random sequence.  Sixteen residents were included. The number of failed intubations was higher with GlideScope in NA and TE scenarios (3 vs 0, in both cases) Mean (SD) time to successful intubation was significantly longer with GlideScope in the NA scenario (GlideScope, 38 [SD, 13] vs Miller, 26 [SD, 16] seconds; P 0.043) The number of maneuvers was significantly higher with GlideScope in the tongue edema and oropharyngeal edema scenario (2.3 [SD, 1.5] vs 1.5 [SD, 1] P 0.04) Upper jaw injury index was significantly lower with GlideScope in NA (2.0 [SD, 1] vs 2.6 [SD, 0.8] P 0.008) and cervical collar (2.1 [SD, 1.0] vs 2.8 [SD, 0.5] P 0.011) scenarios. Participants considered GlideScope technique more difficult than standard Miller in NA (5 [SD, 2.0] vs 3 [SD, 1.3] P 0.04) and TE (5.9 [SD, 2.5] vs 3.9 [SD, 1.7] P 0.02) scenarios.  In simulated scenarios of infant NA and difficult airway, when used by pediatric residents, GlideScope did not improve intubation performance when compared with the standard laryngoscope. Nevertheless, GlideScope may be safer for upper jaw injury and could have advantages in the management of complicated airway. Further studies are needed to assess if specific training will improve GlideScope intubation performance and whether the "in simulator" results translate into clinical practice.
Ageing in place with the use of ambient intelligence technology: Perspectives of older users
Year: 2011

Ambient intelligence technologies are a means to support ageing in place by monitoring clients in the home. In this study, monitoring is applied for the purpose of raising an alarm in an emergency situation, and thereby, providing an increased sense of safety and security. Apart from these technological solutions, there are numerous environmental interventions in the home environment that can support people to age in place. The aim of this study was to investigate the needs and motives, related to ageing in place, of the respondents receiving ambient intelligence technologies, and to investigate whether, and how, these technologies contributed to aspects of ageing in place.  This paper presents the results of a qualitative study comprised of interviews and observations of technology and environmental interventions in the home environment among 18 community dwelling older adults with a complex demand for care. These respondents had a prototype of the Unattended Autonomous Surveillance system, an example of ambient intelligence technology, installed in their homes as a means to age in place. The UAS system offers a large range of functionalities, including mobility monitoring, voice response, fire detection, as well as wandering detection and prevention, which can be installed in different configurations.  The respondents had various motives to use ambient intelligence technologies to support ageing in place. The most prominent reason was to improve the sense of safety and security, in particular, in case of fall incidents, when people were afraid not to be able to use their existing emergency response systems. The ambient intelligence technologies were initially seen as a welcome addition to strategies already adopted by the respondents, including a variety of home modifications and assistive devices. The systems tested increased the sense of safety and security and helped to postpone institutionalisation. Respondents came up with a set of specifications in terms of the operation and the design of the technology. False alarms were also regarded as a sign that the ambient intelligence technology is functioning. Moreover, a good integration of the new technologies in the provision of health Corresponding author at: Hogeschool Utrecht, Faculteit Gezondheidszorg, Bolognalaan 101, 3584 CJ Utrecht, The Netherlands. Tel. +31 30 258 5342; fax: +31 3
Nitric oxide, a new player in L DOPA induced dyskinesia?
Venue: Frontiers in bioscience
Year: 2015

L 3,4 Dihydroxyphenylalanine (L DOPA) remains the most effective symptomatic treatment of Parkinson's disease (PD) However, the long term use of L DOPA causes, in combination with disease progression, the development of motor complications termed L DOPA induced dyskinesia (LID) LID is the result of profound modifications in the functional organization of the basal ganglia circuitry. There is increasing evidence of the involvement of non dopaminergic systems on the pathophysiology of LID. This raises the possibility of novel promising therapeutic approaches in the future, including agents that interfere with glutamatergic, serotonergic, adenosine, adrenergic, and cholinergic neurotransmission that are currently in preclinical testing or clinical development. Herein, we summarize the current knowledge of the pharmacology of LID in PD. More importantly, this review attempts to highlight the role of nitric oxide (NO) in PD and provide a comprehensive picture of recent preclinical findings from our group and others showing its potential involvement in dyskinesia.
Guided systems engineering by profiled ontologies
Year: 2017

Engineering phase specific tailored views on data are required to prevent over engineering and to discover missing elements. This paper presents an approach to enhance a semantic Conceptual Data Model (CDM) to define the specific behavior of engineering phases. Therefore, a CDM gets enhanced by an ontology profile to specify required and non admissible features for each engineering phase. This is exploited to enhance existing transformations from Web Ontology Language (OWL) to Eclipse Modeling Language (EMF) to generate phase specific decorators representing the corresponding views on data items. The approach also supports engineering phase specific handling of constraints and rules that further augment the guidance of engineers through the system development process by applying knowledge management functions such as reasoning. As a result, the presented approach reveals a notably higher data quality and offers more analysis potential by enabling phase specific definitions of views on data and specification of semantic checks on CDM level. Several use cases from aerospace engineering have been analyzed and the improvements in areas such as inconsistency detection, knowledge derivation, and guided system modeling are highlighted in this paper.
Diverse Image to Image Translation via Disentangled Representations
Venue: ECCV
Year: 2018

Image to image translation aims to learn the mapping between two visual domains. There are two main challenges for many applications: (1) the lack of aligned training pairs and (2) multiple possible outputs from a single input image. In this work, we present an approach based on disentangled representation for producing diverse outputs without paired training images. To achieve diversity, we propose to embed images onto two spaces: a domain invariant content space capturing shared information across domains and a domain specific attribute space. Using the disentangled features as inputs greatly reduces mode collapse. To handle unpaired training data, we introduce a novel cross cycle consistency loss. Qualitative results show that our model can generate diverse and realistic images on a wide range of tasks. We validate the effectiveness of our approach through extensive evaluation.
[Progress in B cell targeting therapy for the treatment of systemic lupus erythematosus]
Venue: Journal of UOEH
Year: 2011

Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease characterized by multi organ manifestation. Although the etiology of the disease remains unclear, the activation of autoreactive T cells and production of antibodies by B cells are mainly involved in the pathological processes of the disease. B cell depletion therapy using anti CD20 antibody rituximab has shown a rapid onset of effect and prolonged efficacy in refractory SLE, emerging as a promising new agent for the treatment of SLE. We also reported that rituximab is safe for the treatment of active SLE in a domestic pilot study and a multi center phase I/II clinical trial. In regard to the mechanism underlying the efficacy of rituximab, it has been reported that the drug caused peripheral depletion of memory B cells and plasma cells. We found that rituximab efficiently depleted naive and memory B cells and decreased co stimulatory molecules on B cells and memory T cells. Recovered B cells in patients in long term remission were dominated by naive B cells with an increased ratio of naive T cells, and co stimulatory molecules remained low. These findings indicate that the reconstitution of the B cell compartment results in the inhibition of T cell activation by memory B cells, which leads to the sustained remission of SLE by rituximab. Although the recent placebo controlled trials such as EXPLORER with rituximab in SLE did not achieve satisfactory results, other evidence continues to be published in support of the notion that B cell depletion could be useful for refractory SLE. In addition, other B cell targeted therapies, such as CD22 and agents that interrupt B T cell interaction, including belimumab, also have potential of the therapeutic application.
A contact algorithm for voxel based meshes using an implicit boundary representation
Venue: Computer Methods in Applied Mechanics and Engineering
Year: 2019

Numerical methods operating on structured grids have become popular since they offer good run time performance and are able to process directly voxel based digital data from image recordings. Hence, the general framework of these fast solvers presupposes an unfitted boundary approximation avoiding complicated meshing of bodies. This allows an efficient handling with geometrical issues. Nevertheless, contacts between deformable solids are hard to deal with in the presence of this boundary representation. For this difficulty we suggest the usage of an implicit boundary representation combined with a modified saddle point formulation, resembling Nitsche's approach. Both ideas give an elegant approach for discretizing the contact terms and enable a simple contact detection. Moreover, we suggest an intermediate surface as new reference contact area which fits well into our proposed method. In the end we present numerical results and analyze the accuracy and convergence rate. Furthermore, we demonstrate the current application range of our approach for problems with multiple contacts. In this paper we focus only on frictionless contact with small deformations.
First record of the Dhole Cuon alpinus (Mammalia: Carnivora: Canidae) in Barandabhar Corridor Forest, Chitwan, Nepal
Year: 2018

Systematic Camera trapping on the Barandabhar Corridor Forest recorded the presence of the endangered Wild Dog/Dhole in the area. A total of 1320 camera trap night efforts were conducted in the area in two blocks from 15 th Dec 2015 to 20 th Jan 2016. A single picture of dhole was captured and was sympatric with other large carnivores like tiger Panthera tigris tigris leopard P. pardus and golden jackal Canis aureus This first record of Dhole outside the National Park opened a new gate for officials, wildlife conservationist, scientific communities, managers to think about its conservation. It also adds the proof of the healthy functionality of this corridor.
Diseno de estrategias de marketing digital para la Cooperativa de Ahorro y Credito "Juan Pio de Mora" Limitada
Year: 2019

La presente investigacion tuvo como principal objetivo saber cual es el aporte del marketing digital dentro de la recuperacion y fidelizacion de socios de la Cooperativa de Ahorro y Credito "Juan Pio de Mora" Limitada, para lo cual se realizo una investigacion de tipo experimental y de diseno transversal, con un enfoque cuantitativo y cualitativo, se aplico dos encuestas una dirigida a los socios con cuentas inactivas dando un total de 376 encuestas, realizando preguntas para conocer los motivos por las cuales mantiene la cuenta inactiva, y la otra a los socios con cuentas activas para fortalecer la fidelizacion con un total de 373 encuestas, para conocer lo que desean obtener los socios de beneficios adicionales. Los medios por los cuales quisieran conocer mas informacion de la Cooperativa, de la misma manera se realizo una ficha de observacion para conocer el estado actual en el que se encuentran los medios de comunicacion oficiales. Los resultados obtenidos muestran las diferentes percepciones que tienen los socios sobre el manejo de la informacion en redes sociales de la Cooperativa, siendo esta poco satisfactoria pues los medios oficiales no son utilizados correctamente, no ofrecen informacion relevante y esta no es actualizada constantemente por lo que nadie sigue estas paginas. Con los resultados obtenidos se desarrollaron estrategias de marketing digital para fortalecer la comunicacion entre la cooperativa y los clientes, tener un mejor funcionamiento de medios de comunicacion oficiales. Se concluyo que el marketing digital es de gran ayuda dentro de la comunicacion externa pues ofrece al socio una relacion de forma rapida y directa. Se recomienda la implementacion de la propuesta mediante el departamento de marketing, el area de publicidad y los directivos.
Strategic Approaches to Increasing the Investment Attractiveness through a Supply Chain Management: Foreign and Domestic Experience
Year: 2020

The study proposes the definitions of the concepts of "supply chain management" "investment attractiveness of supply chain managements" "increasing the investment attractiveness of a supply chain management" and "investment gap" The methodological foundations for assessing the investment attractiveness of regions are presented. The study summarizes strategic approaches to increasing the investment attractiveness of the region proposed by Russian and foreign scientists and researchers. The research describes strategic approaches to increasing the investment attractiveness of a supply chain management with due regard to the systemic factors of increasing the investment attractiveness of a supply chain management: the development and implementation of strategic planning, targeted training of personnel. The key elements of a strategy to increase the investment attractiveness of a supply chain management, in particular, strategic indicators and measures, have been proposed. The implementation of the strategic approaches described in the study will increase the number of regional projects and the efficiency of investment resource management, improve the socio economic development of the area, as well as the coverage of measures aimed at investment development. Keywords strategy, investment attractiveness, supply chain management, indicators, activities.
A 1 Mbps 158 pJ/bit Bluetooth Low Energy (BLE) Compatible Backscatter Communication Uplink for Wireless Neural Recording in an Animal Cage Environment
Venue: 2019 IEEE International Conference on RFID (RFID)
Year: 2019

Neuroscience research in non human primates (NHPs) would benefit from multi day neural recordings from freely moving animals in unconstrained home cage environments. However, wireless brain computer interfaces (BCI) face two major challenges. First, a metal animal cage forms a reverberant cavity that leads to dense multipath, impairing the wireless communication channel. Second, the battery life of existing wireless neural recording devices is limited by the energy consumption of the neural data uplink.In this paper, we characterize the channel transfer function of a metal NHP home cage in the 2.4 GHz industrial, scientific, and medical (ISM) band, and demonstrate that there is adequate signal strength and bandwidth to support low power Bluetooth Low Energy (BLE) compatible backscatter data uplinks. For a typical cage and antenna system, the measured maximum insertion loss of the cage antenna system was 27.4 dB and the minimum 3 dB bandwidth was 5.0 MHz. We demonstrate a 1 Mbps BLE compatible backscatter communication link achieving a worst case packet error rate of 1.05% yielding an effective bit error rate of 5.6x10 5, exceeding the BLE requirement of 10 3. The backscatter link has a measured energy consumption of 158 pJ/bit, compared with 10nJ/bit for existing WiFi and Bluetooth chipsets.
Family planning and contraceptive decision making by economically disadvantaged, African American women.
Venue: Contraception
Year: 2013

Significant racial disparities exist in the US unplanned pregnancy rate. We conducted a qualitative study using the theory of planned behavior as a framework to describe how low income, African American women approach family planning.  Structured focus groups were held with adult, low income, nonpregnant, African American women in Connecticut. Data were collected using a standardized discussion guide, audio taped and transcribed. Four independent researchers coded the transcripts using the constant comparative method. Codes were organized into overarching themes.  Contraceptive knowledge was limited, with formal contraceptive education often occurring after sexual debut. Attitudes about contraception were overtly negative, with method effectiveness being judged by the presence of side effects. Family and friends strongly influence contraceptive decisions, while male partners are primarily seen as a barrier. Contraceptive pills are perceived as readily accessible, although compliance is considered a barrier.  Contraception education should occur before sexual debut, should involve trusted family and community members and should positively frame issues in terms of achieving life goals.
How to Cope with Change? Preserving Validity of Predictive Services over Time
Venue: HICSS
Year: 2019

Companies more and more rely on predictive services which are constantly monitoring and analyzing the available data streams for better service offerings. However, sudden or incremental changes in those streams are a challenge for the validity and proper functionality of the predictive service over time. We develop a framework which allows to characterize and differentiate predictive services with regard to their ongoing validity. Furthermore, this work proposes a research agenda of worthwhile research topics to improve the long term validity of predictive services. In our work, we especially focus on different scenarios of true label availability for predictive services as well as the integration of expert knowledge. With these insights at hand, we lay an important foundation for future research in the field of valid predictive services.
EVALUATION DE L'EFFET TOXIQUE DU PLOMB SUR CERTAINS PARAMETRES DE CROISSANCE DU RADIS " RAPHANUS SATIVUS L"
Year: 2017

RESUME La pollution par le plomb est devenue un veritable probleme menacant nos ecosystemes, avec des effets prejudiciables sur la production vegetale et sur la biodiversite, c'est pourquoi actuellement de nombreuses recherches sont axees sur de nouvelles methodes plus ecologiques comme la phytoremediation. Le travail entrepris s'enregistre dans la perspective d'etudier le comportement physio biochimique de la plante du radis (Raphanus sativus L. en reponse a des apports excessifs de Plomb dans le milieu de croissance et l'evaluation de sa tolerance a ce polluant, pour l'utiliser dans la phytoremediation des sols contamines. Les resultats obtenus montrent des modifications apparentes dans les differents parametres etudies chez les plantes stressees par rapport aux temoins. Dans ce cadre, des doses de (250, 500 et 1000 mg/l) d'acetates de plomb sont appliquees sur des graines de radis (Raphanus sativus L. par rapport a un temoin (absence du Pb pendant deux mois. Des modifications histologiques, au niveau des tiges (deformation des parois des cellules du parenchyme medullaire) et des racines (occlusion des vaisseaux de xyleme) ont ete observees. Des changements histologiques au niveau des tiges (deformation des parois des cellules du parenchyme medullaire) et les racines (occlusion des vaisseaux du xyleme) ont ete observes. Cependant, une forte correlation entre Pb du sol et des plantes Pb a ete remarquee. En consequence, l'absorption de plomb par Raphanus sativus est influencee par sa biodisponibilite dans le sol.
Inhibition of cell proliferation and migration by Oroxylum indicum extracts on breast cancer cells via Rac1 modulation
Venue: Journal of pharmaceutical analysis
Year: 2020

In this study, we investigated how Oroxylum indicum leaf and fruit extracts affect the viability and migration of MCF 7 breast cancer cells and the mechanisms of action responsible for these effects. MCF 7 cells treated with the extracts were examined using the sulforhodamine B, colony formation and caspase 3 activity assays, and by Western blotting. O. indicum extracts were found to inhibit MCF 7 cell growth in a concentration and time dependent manner, with 48 h IC50 values of 57.02 2.85 mg/mL and 131.3 19.2 mg/mL for leaf and fruit extracts, respectively. Further, the O. indicum leaf extract caused a reduction in MCF 7 cell viability, induction of MCF 7 cell apoptosis and ROS formation, and an increase in caspase 3 activity. Also, the two extracts inhibited MCF 7 cell migration and reduced both MMP 9 and ICAMP1 gene expression and MMP9 protein expression. Additionally, O. indicum extracts greatly reduced expression of the cell cycle regulatory protein Rac1 in the mevalonate pathway. In summary, O. indicum leaf and fruit extracts reduce breast cancer cell growth, cell viability and cell migration. O. indicum constituents could, therefore, be useful for augmenting the activity of chemotherapeutic drugs employed to treat breast cancer.
When Oblivious is Not: Attacks against OPAM
Venue: WOOT USENIX Security Symposium
Year: 2020

Enclave platforms like Intel SGX, Sanctum and Keystone promise attractive security guarantees but have not always lived up to their billing, mostly due to side channel leaks in platform implementations. A particularly important side channel in these platforms has been the page fault side channel. This side channel has proven to be particularly problematic because it is deterministic and controllable by a malicious operating system. This paper presents a new attack on the page fault channel that works on the state of art proposal for secure demand paging in enclaves (InvisiPage, ISCA'19) The insight behind the attack is that even if the exact page fault addresses are hidden, the adversary may be able to infer the interval between when a page is evicted from an enclave and when it is fetched back into the enclave. Our evaluation shows this leak is sufficient to: (i) identify which application is being executed in an enclave, (ii) infer confidential details about the inputs to the application, and (iii) function as a covert channel between an untrusted enclave application and a malicious operating system.