nils-herrmann/clean_scirepeval huggingface dataset:
Arthroscopic Superior Capsular Reconstruction with Dermal Allograft for the Treatment of a Massive Irreparable Rotator Cuff Tear.
Venue: JBJS essential surgical techniques
Year: 2020

A massive, irreparable rotator cuff tear represents a challenging treatment scenario with respect to surgical intervention. Traditionally, surgical options have included reverse total shoulder arthroplasty, hemiarthroplasty, or rotator cuff repair; however, these techniques may not necessarily restore proper anatomy to the superior capsule, a structure implicated in the maintenance of subacromial contact pressures and the prevention of superior glenohumeral translation. Indications for arthroscopic superior capsular reconstruction include massive, irreparable supraspinatus and/or infraspinatus tears and failure of conservative treatment beyond subjective pain thresholds and dysfunction tolerability. Adequate latissimus dorsi, pectoralis major, and deltoid function helps to ensure the appropriate level of shoulder stability and the ability to complete the necessary rehabilitation protocol. The current surgical guide details the clinical evaluation, surgical technique, and rehabilitation protocol for patients undergoing arthroscopic superior capsular reconstruction for a massive, irreparable rotator cuff tear involving the subscapularis, supraspinatus, and infraspinatus. The procedure is performed arthroscopically with the patient in a beach chair position, starting first with anterior and lateral portal placement for comprehensive diagnostic shoulder arthroscopy assessing rotator cuff damage. Single row suture repair of the subscapularis and infraspinatus is performed, followed by concomitant subacromial bursectomy, decompression, and coracoplasty to aid in visualization, avoid graft abrasion, and provide access to marrow elements. Suture anchor placement, allograft fixation, and appropriate suture management are highlighted, as well as rehabilitation timelines, complications, and clinical pearls.
Monoamine transporters: structure, intrinsic dynamics and allosteric regulation
Venue: Nature Structural Molecular Biology
Year: 2019

Monoamine transporters (MATs) regulate neurotransmission via the reuptake of dopamine, serotonin and norepinephrine from extra neuronal regions and thus maintain neurotransmitter homeostasis. As targets of a wide range of compounds, including antidepressants, substances of abuse and drugs for neuropsychiatric and neurodegenerative disorders, their mechanism of action and their modulation by small molecules have long been of broad interest. Recent advances in the structural characterization of dopamine and serotonin transporters have opened the way for structure based modeling and simulations, which, together with experimental data, now provide mechanistic understanding of their transport function and interactions. Here we review recent progress in the elucidation of the structural dynamics of MATs and their conformational landscape and transitions, as well as allosteric regulation mechanisms. Monoamine transporters (MATs) regulate neurotransmission via the reuptake of dopamine, serotonin and norepinephrine from the extra neuronal space. This Review discusses recent advances in elucidating the structural dynamics and allosteric regulation of MATs.
Development Fundamental Movement Learning Model Based On Team Games Tournament (TGT) For Elementary School Children
Year: 2020

This study aims to develop a fundamental basic motion model based on the Team Games Tournament (TGT) for elementary school children. This study uses a research approach development of Research and Development (R&D) research and development model Borg and Gall. Development of a fundamental Motion Learning Model that will be developed in accordance with the characteristics of children aged 6 12 years who are at the elementary school level.The data collection technique starts from the analysis of the need for the development of fundamental basic movements, the making of initial product drafts, expert validation, product improvement, small scale trials, first revisions, field trials, second revisions, final fundamental basic motion learning model product results. The research sample in the needs analysis of 10 respondents (teachers of Physical Education, Sports and Health) with the generalization results that70% of respondents said they needed the development of a TGT based fundamental motion learning model and were willing to use basic motion development models to improve children's fundamental basic movement mastery. Then testing the development of the fundamental based motion learning model Team Games Tournament (TGT) in the small scale trial, there were 30 students at SDN Kalangsurya III, Rengasdengklok District and 10 students in the main field test at SDIT Salman Al Farisy and SDN Kalangsari III, Rengasdengklok District. All forms of obstacles in the trial of the development of the TGT based fundamental motion learning model and practitioners' input have been revised for the sake of product development perfection. Thus the development of a fundamental based motion learning model Team Games Tournament (TGT) for elementary school children it is declared fit for use in the learning process of Physical Education, Sports and Health in primary schools in accordance with the material in related basic competencies.
Manejo psicologico del nino en la consulta estomatologica
Year: 2015

La relacion humana estomatologo nino padres en el ejercicio de la Odontopediatria es fundamental para el exito del tratamiento. El desarrollo psicologico por edades debe servir de base para comprender la respuesta normal del nino en relacion con su medio, a medida que crece y se desarrolla. Las reacciones emocionales mas frecuentes en el nino ante el trata!miento dental son: temor, ansiedad, resistencia, regresion, retraccion, timidez. Las categorias de comportamiento de acuerdo al conjunto de reacciones emociona!les que presentan ante el tratamiento dental se agrupan en: conducta cooperativa, conducta no cooperativa y conducta potencialmente no cooperativa. Lograr un estado emocional adecuado en los ninos con la ayuda del Estomatologo General Integral, aplicando las diferentes tecnicas de manejo y modificacion de la conducta en ellos, le aportara elementos para enfrentarse a los problemas de salud de la infancia con mayor seguridad de poder lograr comunicacion, aceptacion y cooperacion ante el tratamiento estomatologico, ahi se centra el objetivo del presente trabajo.
Microbial colonization of the periodontal pocket and its significance for periodontal therapy
Venue: Periodontology 2000
Year: 2018

The aim of this paper was to evaluate strategies for periodontal therapy from the perspective of periodontal disease being a consequence of microbial colonization of the periodontal pocket environment. In classic bacterial infections the diversity of the microbiota decreases as the disease develops. In most cases of periodontitis, however, the diversity of the flora increases. Most incriminating bacteria are thought to harm tissues significantly only if present in high numbers over prolonged periods of time. Clinical trials have repeatedly demonstrated that scaling and root planing, a procedure that aims to remove subgingival bacterial deposits by scraping on the tooth surface within the periodontal pocket, is effective. At present, for the therapy of any form of periodontal disease, there exists no protocol with proven superiority, in terms of efficiency or effectiveness, over scaling and root planing plus systemic amoxicillin and metronidazole. Some exponents advocate rationing these drugs for patients with a specific microbial profile. However, the evidence for any benefit of bacteriology assisted clinical protocols is unsatisfactory. Treated sites are subject to recolonization with a microbiota similar to that present before therapy. The degree and speed of recolonization depends on the treatment protocol, the distribution patterns of periodontal microorganisms elsewhere in the oral cavity and the quality of the patient's oral hygiene. To limit the use of antibiotics and to avoid accumulation of harmful effects by repeated therapy, further efforts must be made to optimize procedures addressing the microbial colonization and recolonization of the periodontal pocket.
Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells
Venue: Journal of Virology
Year: 2016

The establishment of human cytomegalovirus (HCMV) latency and persistence relies on the successful infection of hematopoietic cells, which serve as sites of viral persistence and contribute to viral spread. Here, using blocking antibodies and pharmacological inhibitors, we document that HCMV activation of the epidermal growth factor receptor (EGFR) and downstream phosphatidylinositol 3 kinase (PI3K) mediates viral entry into CD34+ human progenitor cells (HPCs) resulting in distinct cellular trafficking and nuclear translocation of the virus compared to that in other immune cells, such as we have documented in monocytes. We argue that the EGFR allows HCMV to regulate the cellular functions of these replication restricted cells via its signaling activity following viral binding. In addition to regulating HCMV entry/trafficking, EGFR signaling may also shape the early steps required for the successful establishment of viral latency in CD34+ cells, as pharmacological inhibition of EGFR increases the transcription of lytic IE1/IE2 mRNA while curbing the expression of latency associated UL138 mRNA. EGFR signaling following infection of CD34+ HPCs may also contribute to changes in hematopoietic potential, as treatment with the EGFR kinase (EGFRK) inhibitor AG1478 alters the expression of the cellular hematopoietic cytokine interleukin 12 (IL 12) in HCMV infected cells but not in mock infected cells. These findings, along with our previous work with monocytes, suggest that EGFR likely serves as an important determinant of HCMV tropism for select subsets of hematopoietic cells. Moreover, our new data suggest that EGFR is a key receptor for efficient viral entry and that the ensuing signaling regulates important early events required for successful infection of CD34+ HPCs by HCMV.  HCMV establishes lifelong persistence within the majority of the human population without causing overt pathogenesis in healthy individuals. Despite this, reactivation of HCMV from its latent reservoir in the bone marrow causes significant morbidity and mortality in immunologically compromised individuals, such as bone marrow and solid organ transplant patients. Lifelong persistent infection has also been linked with the development of various cardiovascular diseases in otherwise healthy individuals. Current HCMV therapeutics target lytic replication, but not the latent viral reservoir; thus, an understanding of the molecular basis for viral latency and persistence is paramount to controlling or eliminating HCMV infection. Here, we show that the viral signalosome activated by HCMV binding to its entry receptor, EGFR, in CD34+ HPCs initiates early events necessary for successful latent infection of this cell type. EGFR and associated signaling players may therefore represent promising targets for mitigating HCMV persistence.
STAT3 in the systemic inflammation of cancer cachexia.
Venue: Seminars in cell developmental biology
Year: 2016

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle atrophy and adipose wasting in cachexia; however cachexia is a truly systemic phenomenon. Presence of the tumor elicits an inflammatory response and profound metabolic derangements involving not only muscle and fat, but also the hypothalamus, liver, heart, blood, spleen and likely other organs. This global response is orchestrated in part through circulating cytokines that rise in conditions of cachexia. Exogenous Interleukin 6 (IL6) and related cytokines can induce most cachexia symptomatology, including muscle and fat wasting, the acute phase response and anemia, while IL 6 inhibition reduces muscle loss in cancer. Although mechanistic studies are ongoing, certain of these cachexia phenotypes have been causally linked to the cytokine activated transcription factor, STAT3, including skeletal muscle wasting, cardiac dysfunction and hypothalamic inflammation. Correlative studies implicate STAT3 in fat wasting and the acute phase response in cancer cachexia. Parallel data in non cancer models and disease states suggest both pathological and protective functions for STAT3 in other organs during cachexia. STAT3 also contributes to cancer cachexia through enhancing tumorigenesis, metastasis and immune suppression, particularly in tumors associated with high prevalence of cachexia. This review examines the evidence linking STAT3 to multi organ manifestations of cachexia and the potential and perils for targeting STAT3 to reduce cachexia and prolong survival in cancer patients.
Mycoprotein: A Healthy New Protein With a Low Environmental Impact
Year: 2017

Something is broken in the way we produce and consume our food. Our food and agriculture now contribute to 30% of global greenhouse gas emissions with half associated with the production of meat. Land and water use are reported to become the new oil in global politics as food security becomes a more pressing risk for a sustainable food future. Half the world's antibiotics are fed to industrially farmed animals, contributing to the rise of deadly superbugs, whilst cereals and crops that could be used to nourish the world's poorest are increasingly grown as animal fodder and a hugely inefficient conversion of protein and environmental damage. There seems no doubt that our desire for ever cheaper and more plentiful meat is at the heart of issues of food sustainability that threaten our very way of life. Indeed, we can no longer meaningfully separate our dietary choices from their impact on the health of our bodies and of the planet. We need to change the balance by eating less and better quality meat and sometimes none at all. We need new ideas and new and healthy proteins with a low environmental impact to help us achieve this. Foods such as Quorn are already helping consumers transition away from an overdependence on meat in short, we need a culture change. Mycoprotein is the world's first successful "new" protein source. From an idea conceived in the 1960s, mycoprotein is now at the heart of all Quorn foods sold in 16 countries worldwide. This chapter explains the origins and history as well as the manufacturing technology, underpinning science, and the process undertaken to establish a robust lifecycle analysis that shows a low environmental impact relative to meat of this technology based on fungal fermentation.
Spatiotemporal and plantar pressure patterns of 1000 healthy individuals aged 3 101 years.
Venue: Gait posture
Year: 2017

The purpose of this study was to establish normative reference values for spatiotemporal and plantar pressure parameters, and to investigate the influence of demographic, anthropometric and physical characteristics.  In 1000 healthy males and females aged 3 101 years, spatiotemporal and plantar pressure data were collected barefoot with the Zeno(tm) walkway and Emed(r) platform. Correlograms were developed to visualise the relationships between widely reported spatiotemporal and pressure variables with demographic (age, gender) anthropometric (height, mass, waist circumference) and physical characteristics (ankle strength, ankle range of motion, vibration perception) in children aged 3 9 years, adolescents aged 10 19 years, adults aged 20 59 years and older adults aged over 60 years.  A comprehensive catalogue of 31 spatiotemporal and pressure variables were generated from 1000 healthy individuals. The key findings were that gait velocity was stable during adolescence and adulthood, while children and older adults walked at a comparable slower speed. Peak pressures increased during childhood to older adulthood. Children demonstrated highest peak pressures beneath the rearfoot whilst adolescents, adults and older adults demonstrated highest pressures at the forefoot. Main factors influencing spatiotemporal and pressure parameters were: increased age, height, body mass and waist circumference, as well as ankle dorsiflexion and plantarflexion strength.  This study has established whole of life normative reference values of widely used spatiotemporal and plantar pressure parameters, and revealed changes to be expected across the lifespan.
Zui Xin tekunoroziwoHuo Yong shitaYe Wu huronoinobeshiyon [Liang Zhi naShui Mian noShi Xian to[Sheng Chan Xing noXiang Shang (Yi Liao Jie Hu Fen Ye niokeruAIIoTnoJin Zhan toHuo Yong noFang Xiang Xing
Year: 2019
Social psychology, consumer culture and neoliberalism: A response to Phelps and White (2018)
Venue: Journal for the Theory of Social Behaviour
Year: 2019

The following essay responds to three main issues raised by Phelps and White (2018) in their critical commentary on our article (McDonald, Gough, Wearing Deville, 2017) The first concerns the lack of precision in the conceptualisation of neoliberalism and the recent threats to it as we enter a potentially new phase of capitalism. While we share Phelps and White's concern, we argue that there is value in continuing to use neoliberalism as a concept for understanding some aspects of social behaviour. As to recent threats to neoliberalism, evidence indicates that it will continue to persist in the immediate future. To deal with neoliberalism's conceptual problems in social psychology, Phelps and White advance the potential theory of a 'market derived logics' We commend the authors for pursuing this endeavor, however, we caution that care needs to be taken in its conceptualisation. Lastly, we discuss Phelps and White's disciplinary reflections on social psychology.
Financial Statement Fraud Detection in Indonesia Listed Companies using Machine Learning based on Meta Heuristic Optimization
Venue: 2020 International Workshop on Big Data and Information Security (IWBIS)
Year: 2020

Financial statement is a critical document which form the basis of decisions of various stakeholders in the capital market. Ironically, the phenomenon of fraud on the company's financial statements is not a practice that never happened. Data reported by ACFE in 2020 showed that financial statement fraud is the costliest category of occupational fraud with median loss of $954.000. This study utilizes several machine learning approaches based on meta heuristic optimization to develop robust fraud prediction models in financial statements. Two classification methods were used, namely, Back Propagation Neural Networks and Support Vector Machines. The best classifier in this study is a Support Vector Machine, which parameters are optimized with Genetic Algorithm resulting in 96.15% accuracy.
Case study of residual stresses distribution in steel welded parts using ultrasound
Year: 2017

Residual stresses occur in every welded manufactured structure. Different studies aimed to classify the methods of investigating the residual stresses and to highlight the advantages and disadvantages/limits of each of them. The conclusion is that ultrasonic investigation permits the evaluation of bulk stress state of welded components with acceptable accuracy. Our past research has addressed various aspects of ultrasonic investigation of residual stresses in welded steel parts: different cases of the analysis of residual stresses, edge effect on analyses of residual stresses. The purpose of this paper is to continue the previous research by introducing a new case: comparative study of equal size samples obtained by splitting an initial sample. The probe was conceived as a frame with a detachable side. After welding, the assembly is processed on a grinding machine to ensure parallel surfaces. The sample, as obtained, is ultrasonic investigated as part. After that, the detachable side is removed and the resulted part is split in six equal samples. Every so obtained sample was investigated and results are presented. New direction for future research is proposed.
The effects of Hegu point ice massage on post sternotomy pain in patients undergoing coronary artery bypass grafting: A single blind, randomized, clinical trial
Year: 2020

Pain is considered as one of the most common problems among patients undergoing open heart surgery. We aimed to evaluate the effects of Hegu point ice massage on the level of pain experienced after coronary artery bypass grafting Materials and Methods This is a single blind, randomized, clinical trial, conducted on 80 patients who were recruited via convenience sampling method. The sample was randomly divided into two groups. In the experimental group, ice massage was performed at the Hegu point on the left hand by applying a medium pressure for 10 min (2 min massage, 15 s rest) in postoperative day 1 and 2. In the control group, glass marbles were applied at the Hegu point on the left hand with no pressure and massage for 10 min. Pain intensity was measured in both groups before the intervention and at 30, 60, and 120 min following the intervention.  Following the intervention on the postoperative day 1, the mean pain score for the experimental and control groups was 2.97 1.40 and 3.64 1.56, respectively. For the experimental and control groups on postoperative day 2, the mean pain score was 2.35 1.12 versus 3.03 1.40, respectively. Following the intervention on postoperative day 1, the mean pain score was 2.97 1.40 and 3.64 1.56 in the experimental and control groups, respectively. The mean pain score for the experimental group was 2.35 1.12 compared with 3.03 1.40 for the control group after the intervention on the second postoperative day. Statistically significant differences were revealed for the mean pain score between the two groups after the intervention on the first (p 0.04) and second (p 0.02) postoperative days.  Hegu point ice massage is an effective method for relieving pain associated with coronary artery bypass grafting in specific patients.
On Dynamic Weighting of Data in Clustering with K Alpha Means
Venue: 2010 20th International Conference on Pattern Recognition
Year: 2010

Although many methods of refining initialization have appeared, the sensitivity of K Means to initial centers is still an obstacle in applications. In this paper, we investigate a new class of clustering algorithm, K Alpha Means (KAM) which is insensitive to the initial centers. With K Harmonic Means as a special case, KAM dynamically weights data points during iteratively updating centers, which deemphasizes data points that are close to centers while emphasizes data points that are not close to any centers. Through replacing minimum operator in K Means by alpha mean operator, KAM significantly improves the clustering performances.