nils-herrmann/clean_scirepeval huggingface dataset:
Comparison of Brain Temperature Distribution in Mathematical and Solid Models of Head Thermal Characteristics

Accurate temperature control of brain tissue during hypothermia treatment is necessary in order to prevent secondary brain damage and to avoid various side effects. Thus, the visualization of the intracerebral temperature distribution in hypothermia treatment was studied at the fundamental level. For this purpose a virtual reality technology was used to create a mathematical model that reflects metabolic heat production and Fourier heat conduction in a brain with the necessary parameters based on various clinical models. In the present study, an experimental system was developed to examine a mathematical simulation of the blood flow in a human head by using a solid brain model constructed using silicon rubber in the shape of a brain based on MRI data, taking into account the metabolic heat given off by three film heaters and including six sensors for the measurement of regional brain temperature. The mathematical simulation describes the internal temperature distribution in a brain with a similar structure to the brain solid model. The results of mathematical simulations and experiments using the brain solid model were quite consistent in the steady state, including control of regional temperature. This allows for the performance of heat conduction experiments under conditions similar to those of a living body, in which the internal temperature is clinically difficult to observe. Thus, the mathematical simulation is confirmed to be useful together with experiments using the solid model for the study of future brain hypothermia treatment. C ⃝ 2015 Wiley Periodicals, Inc. Electr Eng Jpn, 193(2): 58–68, 2015; Published online inWiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22642

Field of study: Computer science
The role of coping in the relationship between perceived racism and racism-related stress for Asian Americans : Gender differences

On the basis of stress and coping theory, the authors examined coping as a mediator of the relationship between perceptions of racism and racism-related stress with a sample of Asian American college students (N 336). Results indicated that coping mediated the relationship between racism and racism-related stress differentially by gender. The more that men perceived racism, the more likely they were to use support-seeking coping strategies that were associated with higher levels of racism-related stress. The more that women perceived racism, the more they used active coping strategies that were associated with higher levels of racism-related stress. The findings demonstrate how coping with racism differs for Asian Americans on the basis of gender.

Field of study: Psychology
Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose.

Nitric oxide (NO) and peroxynitrite both inhibit respiration by brain submitochondrial particles, the former reversibly at cytochrome c oxidase, the latter irreversibly at complexes I-III. Both GSH (IC50 =10 microM) and glucose (IC50 = 8 mM) prevented inhibition of respiration by peroxynitrite (ONOO-), but neither glucose (100 mM) nor GSH (100 microM) affected that by NO. Thus, unless ONOO- is formed within mitochondria it is unlikely to inhibit respiration in cells directly, because of reactions with cellular thiols and carbohydrates. However, the reversible inhibition of respiration cytochrome c oxidase by NO is likely to occur (e.g. in the brain during ischaemia) and could be responsible for cytotoxicity.

Field of study: Biology, Computer science
Anomalies of the pyroelectric and dielectric properties of ferroelectric ceramics of the PbZr1-xTixO3 system with 0.06 ≤ x ≤ 0.35 at the R3c↔R3m phase transition

The temperature dependences of the pyroelectric and dielectric properties of ferroelectric ceramics of the PbZr1 − xTixO3 binary system with x = 0.06, 0.07, 0.08, 0.1, 0.15, 0.2, 0.25, 0.3, and 0.35 have been obtained synchronously for each sample in the range of the structural phase transition between the states with the symmetry space groups R3c ↔ R3m. It is established that the temperatures of this phase transition for unpolarized and polarized samples coincide in the range 0.06 ≤ x ≤ 0.15. In this case, the x−T phase diagram, constructed on the basis of the pyroelectric and dielectric data, is in excellent agreement with the X-ray diffraction data on single crystals in this concentration range. The effect of dc electric fields from 5 × 105 V m−1 did not lead to any temperature shifts of the R3c ↔ R3m phase transition for the compositions with 0.06 ≤ x ≤ 0.25.

Field of study: Physics
Clinical, functional and genetic characterization of 16 patients suffering from chronic granulomatous disease variants – identification of 11 novel mutations in CYBB

Chronic granulomatous disease (CGD) is a rare inherited disorder in which phagocytes lack nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. The most common form is the X‐linked CGD (X91‐CGD), caused by mutations in the CYBB gene. Clinical, functional and genetic characterizations of 16 CGD cases of male patients and their relatives were performed. We classified them as suffering from different variants of CGD (X910, X91− or X91+), according to NADPH oxidase 2 (NOX2) expression and NADPH oxidase activity in neutrophils. Eleven mutations were novel (nine X910‐CGD and two X91−‐CGD). One X910‐CGD was due to a new and extremely rare double missense mutation Thr208Arg‐Thr503Ile. We investigated the pathological impact of each single mutation using stable transfection of each mutated cDNA in the NOX2 knock‐out PLB‐985 cell line. Both mutations leading to X91−‐CGD were also novel; one deletion, c.‐67delT, was localized in the promoter region of CYBB; the second c.253‐1879A>G mutation activates a splicing donor site, which unveils a cryptic acceptor site leading to the inclusion of a 124‐nucleotide pseudo‐exon between exons 3 and 4 and responsible for the partial loss of NOX2 expression. Both X91−‐CGD mutations were characterized by a low cytochrome b558 expression and a faint NADPH oxidase activity. The functional impact of new missense mutations is discussed in the context of a new three‐dimensional model of the dehydrogenase domain of NOX2. Our study demonstrates that low NADPH oxidase activity found in both X91−‐CGD patients correlates with mild clinical forms of CGD, whereas X910‐CGD and X91+‐CGD cases remain the most clinically severe forms.

Field of study: Biology, Medicine
The Enlightenment in Spain: Influences Upon New World Policy

The Enlightenment in Spain defies definition. In certain respects it was a viable force opening up new vistas of knowledge and understanding, while in others it was a mild breeze rustling some leaves of insight into the possibility of human equality. For certain of Spain's royal officials, the ideas of the eighteenth century philosophes were refreshing and undeniably sound; for others even the gathering of knowledge in the new encyclopedias was a dangerously democratic trend. In some areas of national life, reforms gained immediate acceptance, in others the old ways remained entrenched. Spain has always been a country of extremes, of absolute alternatives. Spaniards strive to achieve impossible goals or they remain incredibly inert. With the discovery of America their ambitious undertakings excelled those of England or France, but subsequent neglect brought about failures of equal magnitude. In the sixteenth century they thought to conquer the world; in the next their weakened Hapsburg monarchs squandered the wealth of the New World while the country fell into economic ruin.

Field of study: History
Two energy gaps observed in tunneling measurements on hole-doped cuprates: pairing gap and coherent gap

There is a clear discrepancy among the energy-gap values for different 90 K cuprates, inferred from tunneling measurements. By using the phase diagram for hole-doped cuprates we show that tunneling measurements performed on 90 K cuprates, simply, detect two different energy gaps: the pairing gap and the coherent gap, which are identical in conventional superconductors. We find that there are two reasons why tunneling measurements show in one cuprate exclusively the coherent gap while, in another cuprate, they show the pairing gap: (i) the number of CuO2 planes per unit cell in the cuprate, and (ii) the directionality of the tunneling current (along c-axis or ab-plane).

Field of study: Physics
Environmental disruption of host–microbe co-adaptation as a potential driving force in evolution

The microbiome is known to have a profound effect on the development, physiology and health of its host. Whether and how it also contributes to evolutionary diversification of the host is, however, unclear. Here we hypothesize that disruption of the microbiome by new stressful environments interferes with host–microbe co-adaptation, contributes to host destabilization, and can drive irreversible changes in the host prior to its genetic adaptation. This hypothesis is based on three presumptions: (1) the microbiome consists of heritable partners which contribute to the stability (canalization) of host development and physiology in frequently encountered environments, (2) upon encountering a stressful new environment, the microbiome adapts much faster than the host, and (3) this differential response disrupts cooperation, contributes to host destabilization and promotes reciprocal changes in the host and its microbiome. This dynamic imbalance relaxes as the host and its microbiome establish a new equilibrium state in which they are adapted to one another and to the altered environment. Over long time in this new environment, the changes in the microbiome contribute to the canalization of the altered state. This scenario supports stability of the adapted patterns, while promoting variability which may be beneficial in new stressful conditions, thus allowing the organism to balance stability and flexibility based on contextual demand. Additionally, interaction between heritable microbial and epigenetic/physiological changes can promote new outcomes which persist over a wide range of timescales. A sufficiently persistent stress can further induce irreversible changes in the microbiome which may permanently alter the organism prior to genetic changes in the host. Epigenetic and microbial changes therefore provide a potential infrastructure for causal links between immediate responses to new environments and longer-term establishment of evolutionary adaptations.

Field of study: Biology
The plasticity of global proteome and genome expression analyzed in closely related W3110 and MG1655 strains of a well-studied model organism, Escherichia coli-K12.

The use of Escherichia coli as a model organism has provided a great deal of basic information in biomolecular sciences. Examining trait differences among closely related strains of the same species addresses a fundamental biological question: how much diversity is there at the single species level? The main aim of our research was to identify significant differences in the activities of groups of genes between two laboratory strains of an organism closely related in genome structure. We demonstrate that despite strict and controlled growth conditions, there is high plasticity in the global proteome and genome expression in two closely related E. coli K12 sub-strains (W3110 and MG1655), which differ insignificantly in genome structure. The growth patterns of these two sub-strains were very similar in a well-equipped bioreactor, and their genome structures were shown to be almost identical by DNA microarray. However, detailed profiling of protein and gene expression by 2-dimensional gel electrophoresis and microarray analysis showed many differentially expressed genes and proteins, combinations of which were highly correlated. The differentially regulated genes and proteins belonged to the following functional categories: genes regulated by sigma subunit of RNA polymerase (RpoS), enterobactin-related genes, and genes involved in central metabolism. Genes involved in central cell metabolism - the glycolysis pathway, the tricarboxylic acid cycle and the glyoxylate bypass - were differentially regulated at both the mRNA and proteome levels. The strains differ significantly in central metabolism and thus in the generation of precursor metabolites and energy. This high plasticity probably represents a universal feature of metabolic activities in closely related species, and has the potential to reveal differences in regulatory networks. We suggest that unless care is taken in the choice of strains for any validating experiment, the results might be misleading.

Field of study: Biology, Engineering
The annealing effect on Au/a-Si:H/a-Si:H(n-type)/Cr Schottky diodes prepared by an RF magnetron sputtering technique

The annealing effect on Au/a-Si:H/a-Si:H(n-type)/Cr-type Schottky diodes has been investigated. Thin films of amorphous silicon were prepared by an RF magnetron sputtering technique on a glass substrate with Cr contacts and then gold electrodes (area=7.85*10-3 cm2) were fixed under a vacuum of 10-5 Torr. Measured current-voltage characteristics, before and after annealing at about 70-200 degrees C, show significant differences and therefore it has been concluded that the rectification ratio increases and the ideality factor decreases with increasing annealing temperature. The barrier height phi Bn and density of surface states Ds were found to be phi Bn=0.641 and 0.726 eV and Ds=3.47*1013 and 3.30*1013 states cm-2 eV-1 employing Crowell-Sze's and Cowley-Sze's theories respectively. The changes in the current-voltage characteristics were explained by means of surface states at the metal/semiconductor interface.

Field of study: Materials science
Vulnerability curves by centrifugation: is there an open vessel artefact, and are 'r' shaped curves necessarily invalid?

Vulnerability curves using the 'Cavitron' centrifuge rotor yield anomalous results when vessels extend from the end of the stem segment to the centre ('open-to-centre' vessels). Curves showing a decline in conductivity at modest xylem pressures ('r' shaped) have been attributed to this artefact. We determined whether the original centrifugal method with its different rotor is influenced by open-to-centre vessels. Increasing the proportion of open-to-centre vessels by shortening stems had no substantial effect in four species. Nor was there more embolism at the segment end versus centre as seen in the Cavitron. The dehydration method yielded an 'r' shaped curve in Quercus gambelii that was similar to centrifuged stems with 86% open-to-centre vessels. Both 'r' and 's' (sigmoidal) curves from Cercocarpus intricatus were consistent with each other, differing only in whether native embolism had been removed. An 'r' shaped centrifuge curve in Olea europaea was indistinguishable from the loss of conductivity caused by forcing air directly across vessel end-walls. We conclude that centrifuge curves on long-vesselled material are not always prone to the open vessel artefact when the original rotor design is used, and 'r' shaped curves are not necessarily artefacts. Nevertheless, confirming curves with native embolism and dehydration data is recommended.

Field of study: Environmental science
Making distributed applications manageable through instrumentation

The goal of a management system in a distributed computing environment is to provide a centralized and coordinated view of an otherwise distributed and heterogeneous collection of hardware and software resources. The management software will, within a policy framework, monitor, analyse and control network resources, system resources, and distributed application programs. In our research, we are primarily concerned with the management of distributed applications. Of particular interest is how distributed application processes can be made manageable. The work described in the current paper focusses on instrumenting these processes to allow them to respond to management requests, generate management reports, and maintain information required by the management system. We present an instrumentation architecture to support this, and discuss a prototype implementation based on it. This prototype was used to experiment with the management of DCE applications in an OSI-based management environment.

Field of study: Computer science, Engineering
Study of combustion aids in waste heat boiler of ethylene device

The combustion aids are developed and applied in experimental device designed by self for coke combusting in waste heat boiler.The combustion aids are selected based on the comparison of effects.The results show that the coke combustion time is shorted from 150min to 30min by adding 50μL 0 125% combustion aid H-3 to 0 3g coke.

Field of study: Chemistry, Environmental science
γ-ABC: Outlier-Robust Approximate Bayesian Computation based on Robust Divergence Estimator

Making a reliable inference in complex models is an essential issue in statistical modeling. However, approximate Bayesian computation (ABC) proposed for highly complex models that have uncomputable likelihood is greatly affected by the sensitivity of the data discrepancy to outliers. Even using a data discrepancy with robust functions such as the Huber function does not entirely bypass its negative effects. In this paper, we propose a novel divergence estimator based on robust divergence and to use it as a data discrepancy in the ABC framework. Furthermore, we show that our estimator has an effective robustness property, known as the redescending property. Our estimator also enjoys ideal properties such as asymptotic unbiasedness, almost sure convergence, and linear time complexity. In ABC experiments on several models, we confirm that our method obtains a value closer to the true parameters than that of other discrepancy measures.

Field of study: Computer science
The Impact of Various Class-Distinction Features on Model Selection in the Mixture Rasch Model

The purpose of the current study is to examine the performance of four information criteria (Akaike's information criterion [AIC], corrected AIC [AICC] Bayesian information criterion [BIC], sample-size adjusted BIC [SABIC]) for detecting the correct number of latent classes in the mixture Rasch model through simulations. The simulation study manipulated various class-distinction features (percentages of class-variant items, magnitudes, and patterns of item difficulty differences) and mixing proportions, assuming that a mixture Rasch model with two latent classes was the true model. Unlike previous studies that showed BIC's superiority to other indices, our findings from this study suggested that the four information criteria had differential performance depending on the percentage of class-variant items and the magnitude and pattern of item difficulty differences under a two-class structure. Furthermore, the present study revealed that AICC and SABIC generally performed as good as or better than their counterparts, AIC and BIC, respectively, for the class-class structure with a sample of 3,000.

Field of study: Education
How Americans Viewed Their Lives in 2005

How did Americans view the state of their nation last year? Robert Blendon and John Benson summarize the results of some fifty surveys over the years that cover a range of economic and social issues. At the end of 2005, a large majority of Americans thought the economy was not faring well. Most Americans felt there were not enough jobs to be had. Yet, if 40 percent or so were worried about meeting some expense or other, the majority said their personal finances were satisfactory.

Field of study: Economics
Neuropsychiatric Symptoms of Epilepsy.

Neuropsychiatric Symptoms of Epilepsy Edited by Marco Mula, Springer 2016. €119.99 (hb). 398 pp. ISBN 9783319221588

The clinical discipline of neuropsychiatry embraces a wide range of conditions at the interface between neurology and psychiatry which are best dealt with by specialists with

Field of study: Medicine, Psychology
Evaluating CALIPSO's 532 nm lidar ratio selection algorithm using AERONET sun photometers in Brazil

Since the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) satellite first began probing the Earth's atmosphere on 13 June 2006, several research groups dedicated to investigating the atmosphere's optical properties have conducted measurement campaigns to validate the CALIPSO data products. Recently, in order to address the lack of CALIPSO validation studies in the Southern Hemisphere, and especially the South American continent, the Lasers Environmental Applications Research Group at Brazil's Nuclear and Energy Research Institute (IPEN) initiated efforts to assess CALIPSO's aerosol lidar ratio estimates using the AERONET sun photometers installed at five different locations in Brazil. In this study we develop a validation methodology to evaluate the accuracy of the modeled values of the lidar ratios used by the CALIPSO extinction algorithms. We recognize that the quality of any comparisons between satellite and ground-based measurements depends on the degree to which the instruments are collocated, and that even selecting the best spatial and temporal matches does not provide an unequivocal guarantee that both instruments are measuring the same air mass. The validation methodology presented in this study therefore applies backward and forward air mass trajectories in order to obtain the best possible match between the air masses sampled by the satellite and the ground-based instruments, and thus reduces the uncertainties associated with aerosol air mass variations. Quantitative comparisons of lidar ratios determined from the combination of AERONET optical depth measurements and CALIOP integrated attenuated backscatter measurements show good agreement with the model values assigned by the CALIOP algorithm. These comparisons yield a mean percentage difference of −1.5% ± 24%. This result confirms the accuracy in the lidar ratio estimates provided by the CALIOP algorithms over Brazil to within an uncertainty range of no more than 30%.

Field of study: Environmental science
Zur Geschwindigkeitsverteilung der Feldelektronen

ZusammenfassungAus der Theorie der Feldemission wird die Verteilung der Geschwindigkeiten der Feldelektronen normal und tangential zur emittierenden Oberfläche abgeleitet. Die Halbwertsbreite der Energieverteilung ergibt sich im ersten Fall etwa dreimal so groß wie im zweiten und liegt für praktisch erreichbare Feldstärken in der Größenordnung einiger zehntel eV. Die bisher vorliegenden Beobachtungen zeigen dagegen eine rund zehnmal größere Verteilungsbreite. Diese starke Verbreiterung gegenüber dem theoretischen Wert ist wahrscheinlich auf Störungen durch Feldverzerrungen in der Versuchsanordnung zurückzuführen.

Field of study: Physics