nils-herrmann/clean_scirepeval huggingface dataset:
Schedules using noxious stimuli. III. Responding maintained with response-produced electric shocks.

Responding was maintained in two squirrel monkeys under several variations of a 10-min fixed-interval schedule of electric shock presentation. The monkeys were first trained under a 2-min variable-interval schedule of food presentation, and then under a concurrent schedule of food presentation and shock presentation. In one monkey, when shocks (12.6 ma) followed each response during the last minute of an 11-min cycle ending with a timeout period, responding was increased during the first 10 min and suppressed during the last minute of each cycle. When the shock schedule was eliminated, both the enhancement and suppression disappeared, and a steady rate of responding was maintained under the variable-interval schedule. When the food schedule was eliminated, the shock schedule maintained a characteristic fixed-interval pattern of responding during the first 10 min, but suppressed responding during the last minute of each cycle. The fixed-interval pattern of responding was maintained when the timeout period was eliminated and when only one shock could occur at the end of the cycle. In the second monkey, responding under the concurrent food and shock schedule was suppressed when responses produced shocks after 3-min. Under an 11-min cycle, responding continued to be maintained at increasing shock intensities. When the food schedule was eliminated, a fixed-interval pattern of responding was maintained under a 10-min schedule of shock presentation (12.6 ma). Whether response-produced electric shocks suppressed responding or maintained responding depended on the schedule of shock presentation.

Field of study: Biology, Psychology
The impact of initial cooperation fraction on the evolutionary fate in a spatial prisoner's dilemma game

Network reciprocity is discussed in terms of initial cooperation fraction.Simulation reveals the influence from initial condition is significant.The influence is explained from the concept END and EXP the author presented previously. Although the initial cooperation fraction and its arrangement obviously impacts the equilibrium in spatial prisoner's dilemma (SPD) games, most of the previous studies relying on a simulation approach have by conformity assumed a value of 0.5, thus implying an equal distribution of cooperators and defectors as the established premise. This study first points out that depending on target applications, i.e., biological or general evolutionary dynamical systems, we must select the initial cooperation fraction and its spatial distribution carefully to avoid a misleading conclusion. On the basis of comprehensive numerical experiments and a deductive discussion, wherein both the rule of strategy update and the underlying network are varied, we present a panoramic view of the effects of initial cooperation settings on evolutionary dynamics. Several non-trivial findings are revealed concerning the different impacts of deterministic or stochastic updating, or of homogeneous or heterogeneous underlying topology on evolutionary dynamics.

Field of study: Mathematics
Design Sensitivity Analysis of Hyperelastic Structures Using a Meshless Method

A continuum-based design sensitivity analysis method for hyperelastic structures is presented. Analysis is performed using a meshless method, called the reproducing kernel particle method. Yeoh’ s energy density function is used to describe thehyperelastic structural behavior. The meshless method eliminates mesh distortion orentanglement encountered in using e nite element analysis for large deformation structural analysis and structural shape design optimization. Both the adjoint variable and direct differentiation methods are developed for material and shape design variables. An ine nitely long rubber tube, a two-dimensional rubber band, and an engine mount are examples used to demonstrate the feasibility and accuracy of the method.

Field of study: Physics
A plastic capsule technique for the combustion calorimetry of volatile or chemically reactive compounds: The heat of combustion of polythene

There have been several approaches to these problems, but the most efficacious and widely used has been to introduce the substance (usually a liquid) into glass ampoules of suitable size and then to seal these15• Such sealed ampoules completelysatisfyconditions (a) and (b) above, but they have a number of disadvantages. The technique of manufacturing and filling them requires considerable skill, and, even at best, is a hit-and-miss affair. They have to be strong enough to withstand the pressure (30-40 atm) of oxygen in the bomb without bursting and yet not so strong that they fail to break on ignition of the auxiliary burning substance. In general, they fail to satisfy condition ( c) in that the risk of explosion and incomplete combustion is fairly high35• An ingenious way of minimizing these latter difficulties is due to Thompson6• Again, sealing of the ampoules is a very delicate operation since it is liable to cause a certain amount of decomposition of the sample. Finally, there is always the danger that the melting glass may occlude some intermediate products of the combustion, though apparently this does not in general occur to any significant extent5• The above considerations have led us to search for a Straightforward and reliable alternative to the glass ampoule technique, and we believe we have found such in the following simple method for making closed polythene capsules of any desired size or shape.

Field of study: Chemistry
Manuela Pattison-Bacon MD CCFP.

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Dre Manuela Pattison-Bacon aime «tout» de la medecine. «J’ai toujours voulu etre medecin, explique-t-elle. Je n’ai jamais voulu faire autre chose.» Il a juste fallu un peu de temps pour trouver exactement le genre de medecin que Dre Pattison-Bacon devait finalement

Field of study: Medicine
Common weaving approach in mainstream languages for software security hardening

In this paper, we propose a novel aspect-oriented approach based on GIMPLE, a language-independent and a tree-based representation generated by the GNU Compiler Collection (GCC), for the systemization of application security hardening. The security solutions are woven into GIMPLE representations in a systematic way, eliminating the need for manual hardening that might generate a considerable number of errors. To achieve this goal, we present a formal specification for GIMPLE weaving and the implementation strategies of the proposed weaving semantics. Syntax for a common aspect-oriented language that is abstract and multi-language support together with syntax for a core set for GIMPLE constructs are presented to express the weaving semantics. GIMPLE weaving accompanied by a common aspect-oriented language (1) allows security experts providing security solutions using this common language, (2) lets developers focus on the main functionality of programs by relieving them from the burden of security issues, (3) unifies the matching and the weaving processes for mainstream languages, and (4) facilitates introducing new security features in AOP languages. We handle the correctness and the completeness of GIMPLE weaving in two different ways. In the first approach, we prove them according to the rules and algorithms provided in this paper. In the second approach, we accommodate Kniesel's discipline that ensures that security solutions specified by our approach are applied at all and only the required points in source code, taking into consideration weaving interactions and interferences. Finally, we explore the viability and the relevance of our propositions by applying the defined approach for systematic security hardening to develop case studies.

Field of study: Computer science, Engineering
Application of CPML to two-dimension numerical simulation of nuclear electromagnetic pulse from air explosions

The characteristics of different types of MPL were analyzed and the convolutional PML was chosen to truncate the open boundaries in numerical simulation of nuclear electromagnetic pulse from air explosions. On the basis of the split-field PML and the plane-wave solution of electromagnetic field in free space, the unsplit-field PML was constructed. By applying the convolutional theorem of Fourier transform, the discrete iterative equations of electromagnetic field components were presented in the CPML media under the two-dimension prolate-spheroidal coordinate system. The numerical results indicate that the method of CPML can largely decrease calculation errors of boundary fields.

Field of study: Physics
Burn Septicaemia in Kuwait: Associated Demographic and Clinical Factors

To study the demographic and clinical factors associated with burn septicaemia patients in Kuwait.  All burn in-patients, who developed septicaemia at the Burns Unit, Al-Babtain Centre for Burns and Plastic Surgery, Kuwait, during a 9-year period (June 1992 to May 2001) were included in the study. The data were recorded for age, sex, nationality, cause and percentage of burns, inhalation injury, resuscitation, number of episodes, septicaemia on post-burn day, the microorganisms responsible in each episode, treatment and outcome for statistical analysis. Using SPSS (PC version 11.0) software, a probability level of p < 0.05 was considered significant.  Of the 2,082 patients treated in the Burns Unit, 166 [8%; 99 (60%) males and 67 (40%) females] with a mean age of 26 years (range 1–70) had septicaemia. Significantly higher (p < 0.001) cases were recorded among Kuwaiti children (≤14 years) and non-Kuwaitis (25–59 years) than other corresponding age groups. The total body surface area burned ranged from 2 to 95% (mean 42%) and the main cause of burn was flame (77.1%). Inhalation injury was diagnosed in 39 (23.5%) patients. A total of 253 septicaemic episodes occurred in all patients. The majority, 123 (74.1%), had a single episode and the remaining 43 (25.6%) had multiple (2–10) episodes. One hundred and fifty-five (61.3%) episodes were due to gram-positive organisms, mainly methicillin-resistant Staphylococcus aureus, and 32 (12.7%) were polymicrobial. One hundred and twenty-four (74.7%) patients had wound excision and skin grafting procedures and their survival was significantly higher (OR = 4.3; 95% CI: 1.98–9.31) than non-surgically treated patients. Thirty-nine (23.5%) patients died mainly due to multi-organ failure.  The findings indicate that the patients with extensive flame burns were prone to developing septicaemia due mainly to gram-positive bacteria. The surgical excision of eschar and wound covering improved the outcome of the patients while prophylactic antibiotic treatment had no role in the incidence and outcome of the burn patients.

Field of study: Medicine
A correction to 'efficient and secure comparison for on-line auctions'

In this paper, we describe a correction to the cryptosystem proposed in Damgard et al. from Int. J. Applied Cryptography, Vol. 1, No. 1. Although, the correction is small and does not affect the performance of the protocols from Damgard et al., it is necessary, as the cryptosystem is not secure without it.

Field of study: Computer science, Mathematics
Percutaneous surgery for treatment of epidural spinal cord compression and spinal instability: technical note.

An emerging paradigm for treating patients with epidural spinal cord compression (ESCC) caused by metastatic tumors is surgical decompression and stabilization, followed by stereotactic radiosurgery. In the setting of rapid progressive disease, interruption or delay in return to systemic treatment can lead to a negative impact in overall survival. To overcome this limitation, the authors introduce the use of spinal laser interstitial thermotherapy (sLITT) in association with percutaneous spinal stabilization to facilitate a rapid return to oncological treatment.  The authors retrospectively reviewed a consecutive series of patients with ESCC and spinal instability who were considered to be poor surgical candidates and instead were treated with sLITT and percutaneous spinal stabilization. Demographic data, Spine Instability Neoplastic Scale score, degree of epidural compression before and after the procedure, length of hospital stay, and time to return to oncological treatment were analyzed.  Eight patients were treated with thermal ablation and percutaneous spinal stabilization. The primary tumors included melanoma (n = 3), lung (n = 3), thyroid (n = 1), and renal cell carcinoma (n = 1). The median Karnofsky Performance Scale score before and after the procedure was 60, and the median hospital stay was 5 days (range 3-18 days). The median Spine Instability Neoplastic Scale score was 13 (range 12-16). The mean modified postoperative ESCC score (2.75 ± 0.37) was significantly lower than the preoperative score (4.5 ± 0.27) (Mann-Whitney test, p = 0.0044). The median time to return to oncological treatment was 5 days (range 3-10 days).  The authors present the first cohort of sLITT associated with a percutaneous spinal stabilization for the treatment of ESCC and spinal instability. This minimally invasive technique can allow a faster recovery without prejudice of adjuvant systemic treatment, with adequate local control and spinal stabilization.

Field of study: Medicine
On science culture and science education

Science is seeking truth while liberal arts pursue goodness. Science teaches how to do things while liberal arts pursue how to be a man. The above dichotomy, based on the traditional subject\|object model, is worth reconsidering. Science as a culture does not only seek truth but also pursue goodness. The pursuit for goodness is the internal value of science culture. Science is in nature humanism, which is the general background for science and liberal arts. It is deficient that we are yet to have a complete ideology on science culture and science education. A perfect science education should not only involve doing things but also being a human being. We should be fully aware the value of science culture for education. It depends on the self\|improvement of qualities among faculties.

Field of study: Education
G-protein betagamma subunits antagonize protein kinase C-dependent phosphorylation and inhibition of phospholipase C-beta1.

Protein kinase C (PKC) isoforms phosphorylated phospholipase C-beta1 (PLC-beta1) in vitro as follows: PKCalpha >> PKCepsilon; not PKCzeta. PLC-beta3 was not phosphorylated by PKCalpha. G-protein betagamma subunits inhibited the PKCalpha phosphorylation of PLC-beta1 in a concentration-dependent manner. Half-maximal inhibition occurred with 500 nM betagamma. G-protein betagamma subunits also antagonized the PKCalpha-mediated inhibition of PLC-beta1 enzymic activity. PKCalpha, in turn, inhibited the stimulation of PLC-beta1 activity by betagamma. There was little effect of PKCalpha on the stimulation of PLC-beta1 by alphaq/11-guanosine 5'[gamma-thio]triphosphate (GTP[S]). These findings demonstrate that G protein betagamma subunits antagonize PKCalpha regulation of PLC-beta1. Thus betagamma subunits might have a role in modulating the negative feedback regulation of this signalling system by PKC.

Field of study: Biology, Computer science
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.

CARM1 (co-activator-associated arginine methyltransferase 1)/PRMT4 (protein arginine methyltransferase 4), functions as a co-activator for transcription factors that are regulators of muscle fibre type and oxidative metabolism, including PGC (peroxisome-proliferator-activated receptor γ co-activator)-1α and MEF2 (myocyte enhancer factor 2). We observed significantly higher Prmt4 mRNA expression in comparison with Prmt1-Prmt6 mRNA expression in mouse muscle (in vitro and in vivo). Transfection of Prmt4 siRNA (small interfering RNA) into mouse skeletal muscle C2C12 cells attenuated PRMT4 mRNA and protein expression. We subsequently performed additional qPCR (quantitative PCR) analysis (in the context of metabolism) to examine the effect of Prmt4 siRNA expression on >200 critical genes that control (and are involved in) lipid, glucose and energy homoeostasis, and circadian rhythm. This analysis revealed a strikingly specific metabolic expression footprint, and revealed that PRMT4 is necessary for the expression of genes involved in glycogen metabolism in skeletal muscle cells. Prmt4 siRNA expression selectively suppressed the mRNAs encoding Gys1 (glycogen synthase 1), Pgam2 (muscle phosphoglycerate mutase 2) and Pygm (muscle glycogen phosphorylase). Significantly, PGAM, PYGM and GYS1 deficiency in humans causes glycogen storage diseases type X, type V/McArdle's disease and type 0 respectively. Attenuation of PRMT4 was also associated with decreased expression of the mRNAs encoding AMPK (AMP-activated protein kinase) α2/γ3 (Prkaa2 and Prkag3) and p38 MAPK (mitogen-activated protein kinase), previously implicated in Wolff-Parkinson-White syndrome and Pompe Disease (glycogen storage disease type II). Furthermore, stable transfection of two PRMT4-site-specific (methyltransferase deficient) mutants (CARM1/PRMT4 VLD and CARM1E267Q) significantly repressed the expression of Gys1, Pgam2 and AMPKγ3. Finally, in concordance, we observed increased and decreased glycogen levels in PRMT4 (native)- and VLD (methylation deficient mutant)-transfected skeletal muscle cells respectively. This demonstrated that PRMT4 expression and the associated methyltransferase activity is necessary for the gene expression programme involved in glycogen metabolism and human glycogen storage diseases.

Field of study: Biology, Computer science
K−-Proton atomic transitions

The relation between theK}-P scattering length and the X-ray spectrum for the 2p → 1s electromagnetic transition inK−-P atoms is examined. A coupled-channel potential model is used to explicitly calculate the energy of theS-matrix pole in the 1s channel, which is then compared with the energy obtained from the scattering lengths via the standard equation. The X-ray spectrum is calculated and compared with the Lorentzian shape associated with the complex energy of theS-matrix pole. In addition, theK−p branching ratios are compared at threshold and at the complexS-matrix pole energy.

Field of study: Physics
Effects of bias-temperature cycling on electrical characteristics of YBCO/YSZ/Si SulS capacitors

A bias-temperature cycling technique is developed in the electrical characterization of YBa2Cu307−δ/yttria-stabilized zirconia (YSZ)/Si capacitors. This technique can be used to determine the electrical properties of the material components and their interfaces in the capacitor. Capacitance-voltage (C-V) measurements under no or weak illumination at temperatures ranging from 295 to 80K reveal that hysteresis due to mobile ions decreases with cooling and become vanishingly small at about 220K. Upon further cooling, a different mechanism due to traps in the YSZ/Si interface dominates the low-temperature hysteresis and stretchout of the C-V curves, which is evidenced by measurements for the illuminated device at 80K.

Field of study: Materials science
Serological analysis and biochemical characterization of monoclonal antibodies defining antigens of human hepatocellular carcinoma.

A panel of seven murine monoclonal antibodies reactive with human hepatocellular carcinoma (HCC) cell line, SK- HEP-1, resulted in the definition of four distinct antigen systems, designated HB4, HB5, HB1 and HJ2. HB4 antigen was found to be expressed specifically on HCC cell lines and fresh HCC specimens but not on normal liver. Immunoprecipitation tests suggest that the HB4 epitope may be a heat-stable carbohydrate determinant on a high molecular mass molecule. HB5 antigen was found to have less-restricted expression on a panel of normal adult tissues and on melanoma, astrocytoma, sarcoma, neuroblastoma and epithelial cancer cell lines. In fetal and adult liver, HB5 antigen localized to bile canaliculi and ducts. Under reducing conditions, three mAbs detected a Mr 140,000 glycoprotein using lysates of [125-I], [3-H]-glucosamine and [35-S]-methionine labeled SK-HEP-1 cells. Under non-reducing conditions an additional component of greater than Mr 200,000 was also detected. HB1 antigen was found on almost all monolayer cell lines and not on most cultured suspension cells. This antigen was also detected on cultured HCC cells inoculated into nu/nu mice. Immunoprecipitation experiments revealed that the HB1 antigen is a bimolecular complex with an Mr 170,000 alpha chain and Mr 130,000 beta chain under non-reducing conditions, and three subunits of Mr 140,000, Mr 30,000 and Mr 130,000 under reducing conditions. Two antibodies reacted with epitopes on the alpha chain. HJ2 antigenic determinant is a heat-stable component which could not be immunoprecipitated. This most widely expressed antigen was found in secreted form in many of the cells and tissues examined. These antibodies introduce new antigens which may serve as useful markers for the diagnosis, classification and investigation of HCC and other liver diseases.

Field of study: Biology
The Expected Jacobian Outerproduct: Theory and Empirics

The expected gradient outerproduct (EGOP) of an unknown regression function is an operator that arises in the theory of multi-index regression, and is known to recover those directions that are most relevant to predicting the output. However, work on the EGOP, including that on its cheap estimators, is restricted to the regression setting. In this work, we adapt this operator to the multi-class setting, which we dub the expected Jacobian outerproduct (EJOP). Moreover, we propose a simple rough estimator of the EJOP and show that somewhat surprisingly, it remains statistically consistent under mild assumptions. Furthermore, we show that the eigenvalues and eigenspaces also remain consistent. Finally, we show that the estimated EJOP can be used as a metric to yield improvements in real-world non-parametric classification tasks: both by its use as a metric, and also as cheap initialization in metric learning tasks.

Field of study: Computer science
DETERMINATION OF RARE EARTH ELEMENTS IN GEOLOGICAL STANDARD ROCK SAMPLES BY INDUCTIVELY COUPLED PLASMA ATOMIC EMISSION SPECTROMETRY

Rare earth elements in the standard rock samples such as GSJ JG-1, GSJ JB-1, and USGS AGV-1 have been determined simultaneously by inductively coupled plasma atomic emission spectrometry. It has been found that heavy rare earth elements in JG-1 provide lower values when it is dissolved by the acid digestion method.

Field of study: Chemistry