nils-herrmann/clean_scirepeval huggingface dataset:
Can supernova shells feed supermassive black holes in galactic nuclei?

We simulate shells created by supernovae expanding into the interstellar medium (ISM) of the nuclear region of a galaxy, and analyze how the shell evolution is influenced by the supernova (SN) position relative to the galactic center, by the interstellar matter (ISM) density, and by the combined gravitational pull of the nuclear star cluster (NSC) and supermassive black hole (SMBH).We adopted simplified hydrodynamical simulations using the infinitesimally thin layer approximation in 3D (code RING) and determined whether and where the shell expansion may bring new gas into the inner parsec around the SMBH. The simulations show that supernovae occurring within a conical region around the rotational axis of the galaxy can feed the central accretion disk surrounding the SMBH. For ambient densities between 10$^3$ and 10$^5$ cm$^{-3}$, the average mass deposited into the central parsec by individual supernovae varies between 10 to 1000 solar masses depending on the ambient density and the spatial distribution of supernova events. Supernova occurring in the aftermath of a starburst event near a galactic center can supply two to three orders of magnitude more mass into the central parsec, depending on the magnitude of the starburst. The deposited mass typically encounters and joins an accretion disk. The fate of that mass is then divided between the growth of the SMBH and an energetically driven outflow from the disk.

Field of study: Physics
Analysis of cyclic spontaneous switchings in GaN & SiC cascodes by snappy turn-off currents

This paper investigates the crosstalk-induced spontaneous switchings as continuous cycles of turn-on and turn-off transients as a key reliability criterion in SiC and GaN cascode power devices. The paper presents a wide range of measurements to describe the severity of unwanted switching cycles in presence of a few diodes with high turn-off dI/dt which results in a negative gate voltage induced by the source inductance. Modelling is performed which confirms the theory described to explain the root cause of the continued oscillatory transients and comparisons are made with standalone SiC power MOSFETs.

Field of study: Engineering
On specification error in the general linear model and weak mean square error superiority of the mixed estimator

The case of applying mixed estimation to a general linear model that is misspecified due to missing relevant explanatory variables is investigated. It is found that when the prior information is unbiased and independent of the sample information, the mixed estimator is not necessarily weak mean square error superior to the ordinary least squares estimator of the parameters of the model. In fact, the mixed model using the unbiased prior information can accentuate the specification bias.

Field of study: Mathematics
P042 Multiplexed analysis of inflammatory, metabolic and stress markers in obese subjects before and after a defined exercise program

Obesity is characterized by a chronic-low grade inflammation and aberrant regulation of various forms of stress response in key metabolic sites. The white adipose tissue has been identified as the predominant site of obesity-associated inflammatory reactions, which are triggered as a consequence of immune cells infiltration. Physical exercise has been widely recognized for treating obesity and metabolic syndromes. The objectives of this study are: (1) To investigate the release pattern of pro- and anti-inflammatory mediators in obese participants, (2) To evaluate the effect of a defined exercise protocol on their release into the circulation, (3) To correlate their expression with the metabolic and stress markers.  A total of 600 healthy individuals divided into 3 groups using the body mass index as a reference (lean, overweight and obese) are being enrolled in a 6-month defined exercise protocol. Blood samples and abdominal subcutaneous adipose biopsies are collected at baseline (t0) and after 3 (t3) and 6 (t6) months of exercise. Plasma cytokine and metabolic markers levels were assessed simultaneously using the xMAP multiplex immunobead assay technology (Bioplex). Markers of the oxidative stress, namely ROS and TBARS were measured on plasma or serum using commercially available kits. Gene expression profile was done by RT-PCR using RT-profiler- array kits consisting of the heat shock protein panel, obesity panel and the oxidative stress panel. Western blotting and immunohistochemistry techniques were used to validate the gene expression data. Statistical analyses were performed using SAS software.  The analysis carried out on a first set of samples indicated significant release of RANTES in obese individuals compared to lean participants ( P  Our result demonstrated a differential expression of RANTES chemokine in obese participants in comparison to lean control and highlighted its roles in obesity. Exercise was able to restore the normal expression of RANTES. The existence of a negative correlation between RANTES expression and the metabolic and stress responses is suggestive of a pathological role of RANTES and may be considered a potential therapeutic target.

Field of study: Medicine
PREDICTING GRAIN CONSOLIDATION CAUSED BY VERTICAL VIBRATION

A theoretical model was developed to predict vibration induced grain consolidation (vertical settlement) in 
storage bins. In the theory, grain kernels were modeled as spheres connected by elastic springs and frictional dampers. 
Governing differential equations were then developed for this spring-damper system and solved numerically. It was 
hypothesized that grain consolidation was resulted from grain kernels being “pushed” into the adjacent layers by the 
inertial force during vibration. An experiment was conducted to measure grain consolidation in a small model bin filled 
with wheat to validate the predictive model. The bin was subjected to vibration at frequencies of 23, 30, and 48 Hz and 
amplitudes up to 2.3 mm. The predicted grain consolidation compared favorably with the experimental data. It was found 
that the maximum consolidation (density) was independent of the vibration frequency. However, the higher the frequency, 
the lower the amplitude at which the maximum consolidation (density) occurred. Both the vibration amplitude and 
frequency affected the variation of grain consolidation with the grain depth.

Field of study: Agricultural and Food sciences
Some water‐related physical properties of maize root‐cap mucilage

The dry weight (0.1%) and water potential -7 kPa) of root-cap mucilage from 3-d-old axenically grown maize seedlings have been determined. The results suggest strong gelling properties and weak water-holding capacity for the mucilage. Root tips from seedlings grown under low or high water stress were fixed by freeze-substitution. Micrographs showed that in both conditions, mucilage was secreted into the periplasmic space and extruded through the cell wall, though in dry conditions, the mucilage was tightly pressed against the root-cap surface. Histochemical and structural evidence is presented indicating chemical changes in the composition of the mucilage upon extrusion and a sharp increase in its hydration at increasing distance from the secretory cells. The possible functions of the root-cap mucilage in the rhizosphere are examined in light of these findings.

Field of study: Environmental science
The Impact of Respect Versus Neglect of Self-Identities on Identification and Group Loyalty

How do targets deal with a discrepancy between their choice of identity and the way they are categorized by others? In this article, the authors demonstrate that participants’ reactions to this discrepancy depend on whether the way they are actually treated by others respects their chosen identity. Participants whose choice of identity was neglected expressed low identification and little loyalty to the group to which they had been assigned. By contrast, identification and group loyalty were stronger among participants whose choice of identity was respected and who did not differ from controls on these measures. Of importance, only participants whose self-identity was respected also were willing to self-categorize in and express willingness to cooperate with the ascribed group. The implications of these results for the understanding of identity processes in pluralist societies are discussed.

Field of study: Psychology
Orbital insolation forcing of the Indian Monsoon – a motor for global climate changes?

Both modern and ancient Indian summer monsoons are driven by transequatorial pressure differences, directly coupled with the insolation difference between the Northern and Southern subtropical Hemispheres. A high-resolution record of upwelling and dust flux from the western Arabian Sea resembles an insolation-based Indian Summer Monsoon Index. This index and the observed monsoonal climate variations share major elements on the orbital obliquity and precessional band with the Specmap marine oxygen isotope record, representing global ice volume. The long-term evolution of the index mirrors almost exactly the insolation changes at 65°N, showing that the forcing of low latitude climate variability has a structure similar to that of the insolation forcing in the high northern latitudes. Moreover, insolation forcing in the low latitudes directly controls atmospheric processes in the African, Indian and Asian Monsoon, being responsible for a huge amount of transequatorial water vapour and therefore latent heat transport. Millennial-scale variability of the monsoonal climate is concentrated at periodicities near 1100, 1450, 1750 and 2300 years. These cycles are not strictly periodic, but occur in bands, with specific activity phases and amplitude increases during warm stages and interstadials for the 1100- and 1750-yr cycles, whereas the 1450-yr cycle dominates the cold intervals.

Field of study: Environmental science, Geography
Energy resolution of the CdTe-XPAD detector: calibration and potential for Laue diffraction measurements on protein crystals.

The XPAD3S-CdTe, a CdTe photon-counting pixel array detector, has been used to measure the energy and the intensity of the white-beam diffraction from a lysozyme crystal. A method was developed to calibrate the detector in terms of energy, allowing incident photon energy measurement to high resolution (approximately 140 eV), opening up new possibilities in energy-resolved X-ray diffraction. In order to demonstrate this, Laue diffraction experiments were performed on the bending-magnet beamline METROLOGIE at Synchrotron SOLEIL. The X-ray energy spectra of diffracted spots were deduced from the indexed Laue patterns collected with an imaging-plate detector and then measured with both the XPAD3S-CdTe and the XPAD3S-Si, a silicon photon-counting pixel array detector. The predicted and measured energy of selected diffraction spots are in good agreement, demonstrating the reliability of the calibration method. These results open up the way to direct unit-cell parameter determination and the measurement of high-quality Laue data even at low resolution. Based on the success of these measurements, potential applications in X-ray diffraction opened up by this type of technology are discussed.

Field of study: Physics
Factor representations of diffeomorphism groups

We give a new construction of seminite factor representations of the dieomorphism group of euclidean space. These representations are in canonical corre- spondence with the nite factor representations of the inductive limit unitary group. Hence, many of these representations are given in terms of quasi-free representations of the canonical commutation and anti-commutation relations. To establish this correspon- dence requires a generalization of complete positivity as developed in operator algebras. We also compare the asymptotic character formula for the unitary group with the ther- modynamic (N=V ) limit construction for dieomorphism group representations.

Field of study: Mathematics
Classification of amyloid deposits in diagnostic cardiac specimens by immunofluorescence.

At least 12 distinct forms of amyloidosis are known to involve the heart or great vessels. Patient treatment regimens require proper subtyping of amyloid deposits in small diagnostic cardiac specimens. A growing lack of confidence in immunohistochemical staining for subtyping amyloid has arisen primarily as a result of studies utilizing immunoperoxidase staining of formalin-fixed paraffin-embedded tissue. Immunofluorescence staining on fresh frozen tissue is generally considered superior to immunoperoxidase staining for subtyping amyloid; however, this technique has not previously been reported in a series of cardiac specimens.



Amyloid deposits were subtyped in 17 cardiac specimens and 23 renal specimens using an immunofluorescence panel.



Amyloid deposits were successfully subtyped as AL, AH, or AA amyloid by immunofluorescence in 82% of cardiac specimens and 87% of renal specimens. In all cases, the amyloid classification was in good agreement with available clinical and laboratory assessments. A cross-study analysis of 163 cases of AL amyloidosis reveals probable systemic misdiagnosis of cardiac AL amyloidosis by the immunoperoxidase technique, but not by the immunofluorescence technique.



Amyloid deposits can be reliably subtyped in small diagnostic cardiac specimens using immunofluorescence. The practical aspects of implementing an immunofluorescence approach are compared with those of other approaches for subtyping amyloid in the clinical setting.

Field of study: Biology, Medicine
Impaired glucose metabolism in patients with acute stroke and no previous diagnosis of diabetes mellitus.

About a third of patients with acute stroke and no prior diagnosis of diabetes have hyperglycaemia during the acute phase of stroke. Whether this is an acute stress response or a reflection of underlying diabetes is controversial.



To assess whether impaired glucose metabolism in patients with acute ischaemic stroke and no previous diagnosis of diabetes persists after 3 months, and whether such persistence can be predicted.



Prospective observational study.



We enrolled 106 patients with acute ischaemic stroke and no history of diabetes. Fasting blood glucose, serum insulin and the insulin resistance index HOMA were recorded during hospital stay. A standard oral glucose tolerance test was performed at discharge and 3 months later.



Ten patients did not complete the study. Eighty-one patients (84.4%) had abnormal glucose metabolism at discharge and 62 (64.6%) after 3 months. Thirty-seven (38.5%) had impaired glucose tolerance at discharge and 26 (27.1%) after 3 months. Forty-four (45.8%) had diabetes at discharge, and 36 (37.5%) at 3 months. Post-load hyperglycaemia at discharge was a predictor of diabetes after 3 months. A plasma glucose cut-off of 11.7 mmol/l (210 mg/dl) had a specificity of 90.0% and a positive predictive value of 81.3%. HOMA increased progressively from patients with normal glucose metabolism to those with newly diagnosed diabetes.



Impaired glucose tolerance and previously unrecognized diabetes could be detected early in the stroke course, and persisted after 3 months in more than two-thirds of our patients. Post-load hyperglycaemia during the acute phase of stroke may be useful in identifying patients with abnormal glucose metabolism, which places them at risk for adverse outcomes, including cardiovascular disease.

Field of study: Medicine
Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects.

The objective of this study was to assess ethanol's (EtOH's) effects on capsaicin-induced hyperalgesia in healthy participants. Specifically, we investigated the change in area of capsaicin-induced hyperalgesia following 3 interventions: intravenous EtOH at 2 targeted breath alcohol concentrations (BrAC), or placebo.



Eighteen participants participated in 3 test days in a randomized order. Each test day, participants received an intradermal capsaicin injection on the volar surface of the forearm, followed by either infusion of high concentration EtOH (targeted BrAC = 0.100 g/dl), low concentration EtOH (targeted BrAC = 0.040 g/dl), or placebo. The area of hyperalgesia was determined by von Frey technique at 2 time points, prior to EtOH infusion, and again when target BrAC was reached. The primary outcome was the percent change in the area of capsaicin-induced hyperalgesia. Additional outcome measures included the visual analogue scale of mood states (VAS), which was administered at each time point.



There was a marked 30% reduction in the area of capsaicin-induced hyperalgesia with infusion of a high concentration of EtOH (p < 0.05). Low concentration EtOH produced a 10% reduction in hyperalgesia area, although this finding did not reach significance. Further, participants reported significant feelings of euphoria and drowsiness at high concentrations of EtOH (p < 0.05), as measured by the VAS.



In a human model examining pain phenomena related to central sensitization, this study is the first to demonstrate that capsaicin-induced hyperalgesia is markedly attenuated by EtOH. The capsaicin experimental pain paradigm employed provides a novel approach to evaluate EtOH's effects on pain processing. The antihyperalgesic effects of EtOH observed have important clinical implications for the converging fields of substance abuse and pain medicine and may inform why patients with chronic pain often report alcohol use as a form of self-medication.

Field of study: Medicine
Estimating the fitness effect of an insertion sequence

Since its discovery, mobile DNA has fascinated researchers. In particular, many researchers have debated why insertion sequences persist in prokaryote genomes and populations. While some authors think that insertion sequences persist only because of occasional beneficial effects they have on their hosts, others argue that horizontal gene transfer is strong enough to overcome their generally detrimental effects. In this study, we model the long-term fate of a prokaryote cell population, of which a small proportion of cells has been infected with one insertion sequence per cell. Based on our model and the distribution of IS5, an insertion sequence for which sufficient data is available in 525 fully sequenced proteobacterial genomes, we show that the fitness cost of insertion sequences is so small that they are effectively neutral or only slightly detrimental. We also show that an insertion sequence infection can persist and reach the empirically observed distribution if the rate of horizontal gene transfer is at least as large as the fitness cost, and that this rate is well within the rates of horizontal gene transfer observed in nature. In addition, we show that the time needed to reach the observed prevalence of IS5 is unrealistically long for the fitness cost and horizontal gene transfer rate that we computed. Occasional beneficial effects may thus have played an important role in the fast spreading of insertion sequences like IS5.

Field of study: Biology, Mathematics
Excellent wavelength-dependence of laser-induced delayed light-emission from mesophyll and bundle-sheath cells of maize.

Mesophyll and bundle-sheath cells from maize (Zea mays) were examined for delayed light-emission. An enzymic procedure was used to isolate the mesophyll and bundle-sheath cells. A tunable dye laser was used at 695-720 nm to excite delayed light-emission. The mesophyll cells show a typical Photosystem-II dependence on excitation wavelength for delayed light-emission, and this emission was eliminated by hydroxylamine and 3-(3,4-dichlorophenyl)-1,1-dimethylurea. The bundle-sheath cells show no delayed light-emission with these excitation wavelengths. Photosystem-I emission was not observed from either cell type, there being no effect of Methyl Viologen on the observed signals.

Field of study: Biology, Computer science
Structure of the ground and excited states in $_{\Lambda}^{9}$Be nucleus

We investigate properties of bound and resonance states in the $_{\Lambda}^{9}$Be nucleus. To reveal the nature of these states, we use a three-cluster $2\alpha+\Lambda$ microscopic model. The model incorporates Gaussian and oscillator basis functions and reduces a three-cluster Schrodinger equation to a two-body like many-channel problem with the two-cluster subsystems ($_{\Lambda}^{5}$He and $^8$Be) being in a bound or a pseudo-bound state. Influence of the cluster polarization on the energy and widths of resonance states in $_{\Lambda}^{9}$Be and on elastic and inelastic $_{\Lambda}^{5}$He+$\alpha$ scattering is analyzed.

Field of study: Physics
Space travel: bringing medical discoveries down to Earth.

Space travel has necessitated intensive study of certain physical conditions, notably cardiovascular deconditioning, motion sickness, musculoskeletal atrophy and psychological isolation. Benefits of this research are beginning to be available to terrestrial medicine, for example in research on osteoporosis and motion sickness. Other space technology of benefit to medicine includes diagnostic and therapeutic devices, transmission of medical data and satellite communications. A permanently inhabited space station is planned for the 1990s and further research into isolation, occupational hazards in remote locations, transportation of accident victims and stabilization awaiting transportation can be expected, all with probable spinoffs for terrestrial medicine. Space is also a good environment for production of very pure, specific pharmaceuticals, such as alpha1-antitrypsin, interferon and pancreatic beta cells.

Field of study: Medicine
Control of Gas Sorption Gate-opening in Solid Solutions of One-dimensional Coordination Polymers

An isostructural solid solution series of one-dimensional coordination polymers, [(Ru(1−x)Rhx)2(2,4,5-Me3PhCO2)4(phz)] (x = 0, 0.1, 0.22, 0.39, 0.55, and 1; 2,4,5-Me3PhCO2− = 2,4,5-trimethylbenzoat...

Field of study: Chemistry
A COMPARATIVE STUDY ON METHODS FOR ESTIMATING EXTREME WIND-INDUCED RESPONSE OF STRUCTURES

To evaluate the accuracy of some engineering methods for estimating the extreme values of wind induced response, which are usually based on the Gaussion distribution assumption, repeated wind tunnel tests and wind-induced response analysis with over 1000 samples were carried out on a single-layer spherical lattice shell structure, and more than 1000 samples of the structural response time-history were obtained. Secondly, the extreme value of the structural response was analyzed by the method of classical extreme value theory based on the large number of samples, and can be regarded as the reference value. Then, the Peak Factor method, the Modified Hermite Model method, and the Sadek-Simiu method are used seperately to estimate the extreme values of structural response based on only one sample. Finally, statistical analysis is carried out on these estimated values, and the stablity and accuracy of these three methods are investigated. The results indicate that the estimation results from the Peak Factor method have small deviation, but most are underestimated; the estimation results of the Modified Hermite Model method vary greatly, and most are overestimated; the estimation results of the Sadek-Simiu method are close to the reference value. Thus in practice it is recommended to estimate extreme values by the Sadek-Simiu method.

Field of study: Engineering