nils-herrmann/clean_scirepeval huggingface dataset:
Alcohol use and suicidal behavior in women: longitudinal patterns in a U.S. national sample.

Much of the research on suicidality has focused on adolescents and completed suicides, with less attention to types of suicidal behavior (ideation and attempts) that are more common among women. Research has associated women's suicidality with hazardous drinking, adverse childhood experiences, relationship problems, depression, and earlier suicidal behavior. The longitudinal analyses here examine long-term antecedents of suicidal ideation among women in the U.S. general population.



We used 1981 and 1991 survey data to predict post-1991 suicidal ideation in a 1996 national sample of 709 women aged 26 to 54 (538 current drinkers). Predictors included 1991 measures of hazardous drinking, depressive episodes, illicit drug use, general health, children at home, interaction with partner, and previous suicidal ideation. Predictors from childhood included recalled parental drinking, parental love or rejection, early drinking and sexual intercourse, and sexual abuse. Demographic predictors included age, education, and ethnicity. A three-stage structural equation model that included these variables was evaluated with Mplus for women who were drinkers in 1991 and/or 1996.



Almost all women who attempted suicide also reported suicidal ideation. Among women drinkers, suicidal ideation before 1991 was more common in the following groups: Latinas, women who believed that their parents had rejected them, and women who reported childhood sexual abuse. Hazardous drinking and poorer health in 1991, childhood histories of sexual abuse and early drinking, and previous suicidal ideation predicted suicidal ideation after 1991. Domestic stressors in 1991 (inability to share feelings with a partner and having four or more young children at home) also predicted subsequent suicidal ideation, but depressive episodes did not. Suicidal ideation was less likely among women drinkers who reported past illicit drug use.



Suicidal ideation among women drinkers was largely predictable from previous suicidal ideation, hazardous drinking, adverse childhood experiences, and domestic stressors. Higher rates of pre-1991 suicidal ideation among Latinas indicate a need for further study of ethnic influences on suicidality. Reduced suicidal ideation among women with past illicit drug use suggests that conclusions about such use from shorter-term studies may be oversimplified. Understanding women's suicidal ideation, as a precursor to suicidal actions, requires more detailed research on pathways by which hazardous drinking as well as combined distress from childhood experiences and adult domestic environments may increase women's despair and thoughts of suicide.

Field of study: Medicine
Differential modulation by the stress axis of ethanol withdrawal seizure expression in WSP and WSR mice.

Withdrawal from both acute and chronic ethanol (EtOH) exposure is associated with increased neural excitability and increased activity of the hypothalamic-pituitary-adrenal axis. There is some evidence that glucocorticoids are necessary for EtOH withdrawal seizure expression. Lines of mice that were selected for severe (WSP) and minimal (WSR) EtOH withdrawal (as estimated from handling-induced convulsion scores) have been shown to differ in their stress response following an acute dose of EtOH. In this study we provide evidence that these lines of mice also differ in their sensitivity to the excitatory effects of glucocorticoids. EtOH withdrawal seizures of WSP mice were significantly increased by chronic and acute corticosterone treatment, whereas those of the WSR mice were unaffected. Neural excitability was decreased in the WSP mice when aminoglutethimide, a glucocorticoid synthesis blocker, was administered. Thus, it appears that genetic differences in EtOH withdrawal seizure severity may be due, in part, to differences in sensitivity to the excitatory effects of glucocorticoids.

Field of study: Medicine
Unifying Value Iteration, Advantage Learning, and Dynamic Policy Programming

Approximate dynamic programming algorithms, such as approximate value iteration, have been successfully applied to many complex reinforcement learning tasks, and a better approximate dynamic programming algorithm is expected to further extend the applicability of reinforcement learning to various tasks. In this paper we propose a new, robust dynamic programming algorithm that unifies value iteration, advantage learning, and dynamic policy programming. We call it generalized value iteration (GVI) and its approximated version, approximate GVI (AGVI). We show AGVI's performance guarantee, which includes performance guarantees for existing algorithms, as special cases. We discuss theoretical weaknesses of existing algorithms, and explain the advantages of AGVI. Numerical experiments in a simple environment support theoretical arguments, and suggest that AGVI is a promising alternative to previous algorithms.

Field of study: Computer science
Entrance channel effects on the evaporation residue yields in reactions leading to the $^{220}$Th compound nucleus

The evaporation residue yields from compound nuclei $^{220}$Th formed in the $^{16}$O+$^{204}$Pb, $^{40}$Ar+$^{180}$Hf, $^{82}$Se+$^{138}$Ba, $^{124}$Sn+$^{96}$Zr reactions are analyzed to study the entrance channel effects by comparison of the capture, fusion and evaporation residue cross sections calculated by the combined dinuclear system (DNS) and advanced statistical models. The difference between evaporation residue (ER) cross sections can be related to the stages of compound nucleus formation or/and at its surviving against fission. The sensitivity of the both stages in the evolution of DNS up to the evaporation residue formation to the angular momentum of DNS is studied. The difference between fusion excitation functions are explained by the hindrance to complete fusion due to the larger intrinsic fusion barrier $B^*_{\rm fus}$ for the transformation of the DNS into a compound nucleus and the increase of the quasifission contribution due to the decreasing of quasifission barrier $B_{\rm qf}$ as a function of the angular momentum. The largest value of the ER residue yields in the very mass asymmetric $^{16}$O+$^{204}$Pb reaction is related to the large fusion probability and to the relatively low threshold of the excitation energy of the compound nucleus. Due to the large threshold of the excitation energy (35 MeV) of the $^{40}$Ar+$^{180}$Hf reaction, it produces less the ER yields than the almost mass symmetric $^{82}$Se+$^{138}$Ba reaction having the lowest threshold value (12 MeV).

Field of study: Physics
The impact of laparoscopic cholecystectomy in Canada and Australia.

The introduction of laparoscopic cholecystectomy in Canada and Australia has been associated in each country with an increase in the rates of all cholecystectomies following a period where these had remained constant. Estimated costs of cholecystectomies to health programs declined by about 13% in Canada after the laparoscopic procedure became widely available, and about 2% in Australia. Days lost to patients because of surgery, and associated costs to them, decreased in each country. Neither country is realising the potential savings through use of laparoscopic cholecystectomy because of the increase in the number of procedures. The utility of these additional operations remains unclear. These trends associated with the advent of laparoscopic cholecystectomy suggest the need for caution in the introduction and application of other minimal-access surgery techniques.

Field of study: Medicine, Political science
Accommodating Weak Readers in History Research Projects: Using Varied Types of Sources

irtually all middle or high school V classes not limited to advanced students include some weak readers. Norming data for a well-respected reading test indicate that the reading ability levels of 10 percent of students in an average ninth grade class are at the fourth-grade or lower levels and an additional 10 percent are at the fifthgrade level (Woodcock 1998). Because of the importance of reading in history classes, especially for project and research assignments, weak readers must struggle. Difficulty with reading may partially explain why many students dislike history (Loewen 1995). How can secondary-level history teachers help weak readers participate more fully in their assigned project and research work and enjoy that participation? In this article, we take the position that one of the best ways to assist such readers and motivate them is through the use of varied types of source materials in small group settings. We propose

Field of study: Sociology
Profile etching for prefiguring X-ray mirrors.

A method to pre-shape mirror substrates through etching with a broad-beam ion source and a contoured mask is presented. A 100 mm-long elliptical cylinder substrate was obtained from a super-polished flat Si substrate with a 48 nm root-mean-square (r.m.s.) figure error and a 1.5 Å r.m.s. roughness after one profile-etching process at a beam voltage of 600 V without iteration. A follow-up profile coating can be used to achieve a final mirror. Profile etching and profile coating combined provide an economic way to make X-ray optics, such as nested Kirkpatrick-Baez mirrors.

Field of study: Physics
Characterization and Analysis of Whole Transcriptome of Giant Panda Spleens: Implying Critical Roles of Long Non-Coding RNAs in Immunity

Giant pandas, an endangered species, are a powerful symbol of species conservation. Giant pandas may suffer from a variety of diseases. Owing to their highly specialized diet of bamboo, giant pandas are thought to have a relatively weak ability to resist diseases. The spleen is the largest organ in the lymphatic system. However, there is little known about giant panda spleen at a molecular level. Thus, clarifying the regulatory mechanisms of spleen could help us further understand the immune system of the giant panda as well as its conservation.  The two giant panda spleens were from two male individuals, one newborn and one an adult, in a non-pathological condition. The whole transcriptomes of mRNA, lncRNA, miRNA, and circRNA in the two spleens were sequenced using the Illumina HiSeq platform. EBseq and IDEG6 were used to observe the differentially expressed genes (DEGs) between these two spleens. Gene Ontology and KEGG analyses were used to annotate the function of DEGs. Furthermore, networks between non-coding RNAs and protein-coding genes were constructed to investigate the relationship between non-coding RNAs and immune-associated genes.  By comparative analysis of the whole transcriptomes of these two spleens, we found that one of the major roles of lncRNAs could be involved in the regulation of immune responses of giant panda spleens. In addition, our results also revealed that microRNAs and circRNAs may have evolved to regulate a large set of biological processes of giant panda spleens, and circRNAs may function as miRNA sponges.  To our knowledge, this is the first report of lncRNAs and circRNAs in giant panda, which could be a useful resource for further giant panda research. Our study reveals the potential functional roles of miRNAs, lncRNAs, and circRNAs in giant panda spleen.

Field of study: Biology, Chemistry
Discrete-Time Semi-Markov Random Evolutions – Average and Diffusion Approximation of Difference Equations and Additive Functionals

This article introduces discrete-time semi-Markov random evolution and studies asymptotic properties, namely, averaging and diffusion approximation by weak convergence methods. The cases considered here concern difference equations and additive functionals with application in estimation of stationary probability of semi-Markov chains.

Field of study: Mathematics
Research on the security system of the interdisciplinary organization operation in research-oriented universities

In order to ensure the smooth operation of the interdisciplinary organization in research-oriented universities,it's necessary to understand the research progress,the features of the interdisciplinary organization,and the basic theory of its procedure.Based on the analysis,this paper shows the status of interdisciplinary organization operation in research-oriented universities from four dimensions: the internal environment,external environment,software construction and hardware construction.And it also offers the security system for the interdisciplinary organization in research-oriented universities,that is organizational security,policy security,investment protection,cultural protection,personnel and technical support.

Field of study: Education
In vitro antibacterial activity of cocoa ethanolic extract against Escherichia coli.

Cocoa Ethanolic Extract (CEE) was observed for antibacterial activity against Escherichia coli. CEE at different concentrations in E. coli-seeded Mueller-Hinton agar medium, resulted zone of inhibition after 24 h incubation in 37°C. CEE concentrations at 15.6, 31.25, 62.5, 125, 250, 500 and 1,000 mg/ml, developed annular radius of inhibition 0.4, 1.0, 1.9, 3.3, 4.5, 5.3 and 6.31 mm respectively, while 8 μg/ml Ceftriaxone as positive control resulted zone of inhibition 6.48 mm. Minimum Inhibitory Concentration (MIC) to suppress E. coli growth was 835 mg/ ml. Scanning Electron Microscopy (SEM) observation showed that CEE and Ceftriaxone caused bacteria cell elongation. CEE concentration above 15.6 mg/ml induced E. coli cells fragmentation suggesting permanent damage. This research finding clearly indicates that CEE could be an alternative to be used as antibacterial agent with respect to overcome the bacterial resistance.

Field of study: Agricultural and Food sciences
The effect of windthrow and its management on breeding bird communities in a managed forest

This study aimed to evaluate the impact of windthrow and two types of its management on the bird community of a managed, pine-dominated forest (NE Poland), where a windstorm event occurred in 2002. In 2007, the bird species composition was assessed using the point count method in three types of habitat: windthrow left undisturbed for natural regeneration, managed windthrow (all fallen trees removed), and intact forest (undisturbed by the windstorm, used as the control). In total, 2,365 individual birds of 70 species were recorded in the three analyzed habitats. The mean number of individuals per point and species per point was significantly higher in the natural windthrow than in the two other habitats. The diversity of the bird community was higher in the natural and managed windthrow, as compared to the control. The bird community of the control was significantly more similar to that of the natural windthrow than to the one in the managed windthrow. These results lead to a conclusion that the bird community was affected more by the clearing and artificial replanting following the windthrow than by the windthrow itself.

Field of study: Environmental science
Association of SERPINC1 Gene Polymorphism (rs2227589) With Pulmonary Embolism Risk in a Chinese Population

Genetic variants in the gene SERPINC1 have been shown to be associated with antithrombin deficiency, which subsequently contributes to the susceptibility to venous thrombosis. However, several other studies have shown conflicting results regarding the association of SERPINC1 gene polymorphisms (rs2227589) with the risk of thrombosis. Hence, in the present study, we conducted a case-control study to further evaluate the association between the variant rs2227589 with antithrombin deficiency in pulmonary embolism (PTE). A pooled systematic analysis was also conducted to evaluate the risk of rs2227589 in venous thromboembolism (VTE) among multiple populations.  This case-control study involved 101 patients and 199 healthy controls. The allele frequency of SERPINC1 variant rs2227589 was analyzed by Sequenom assay. Antithrombin anticoagulant activity was detected using an automatic coagulation analyzer. In addition, a pooled systematic analysis on 10 cohorts consisting of 5,518 patients with VTE and 8,935 controls was performed.  In total, 27 (26.7%) PTE subjects were diagnosed as having antithrombin deficiency. Our results showed that antithrombin plasma activity was slightly lower in T allele carriers than that in C allele carriers. However, there was no significant correlation between rs2227589 genotype and antithrombin anticoagulant activity. The recessive model showed that rs2227589 was significantly associated (p = 0.026) with an increased risk {odds ratio [OR]: 2.31, 95% confidence interval [CI] (1.09–4.89)} of Chinese PTE. The pooled systematic analysis of all case-control study and meta-analysis showed that rs2227589 polymorphism was associated with an increased risk of VTE in the additive model [OR: 1.09, 95% CI (1.01–1.18), P = 0.029] and dominant model [OR: 1.10, 95% CI (1.01–1.20), P = 0.034].  Our study demonstrated that variant rs2227589 is associated with an increased risk of PTE in a Chinese population but no correlation with antithrombin anticoagulant activity. However, pooled systematic analysis of multiple populations showed a significant association between rs2227589 and the risk of VTE in the additive and dominant genetic model.

Field of study: Biology
Ontology-Based Information Integration Mapping Construction Between Global View and Local Views in Virtual Organization

Information integration is the key approach for achieving information sharing in the virtual organization. From the point of view of implementing information sharing in the virtual organization, how to construct the mapping between the global view and the local views during the information integration was thoroughly studied and an ontology-based two phases mapping construction method was advanced. In the method, based on the ontology, the first phase was devoted to the construction of initial mapping and the second phase was to adjust the mapping according to the information sources change. In the first phase, referred to the GAV (Global as View) the initial mapping between the global view and the local views was founded. In the second phase, referred to the LAV(Local as View) the mapping was adjusted when the information sources change. An example of constructing the mapping between the global view and the local views in the E-Commerce virtual organization was presented to illustrate the way the method works, which also demonstrated the validity of the method.

Field of study: Computer science
Improved superconducting properties of skutterudite La3Co4Sn13 with indium substitution

We report on two fold increase in superconducting transition temperature of La3Co4Sn13 by substituting indium at the tin site. The transition temperature of this skutterudite is observed to increase from 2.5 K to 5.1 K for 10 % indium substituted sample. The band structure and density of states calculations also indicate such a possibility. The compounds exhibit type - II superconductivity and the values of lower critical field (Hc1), upper critical field (Hc2), Ginzburg - Landau coherence length , penetration depth and GL parameter are estimated to be 0.0028 T, 0.68 T, 21.6 nm, 33.2 nm and 1.53 respectively for La3 Co4Sn11.7In1.3. Hydrostatic external pressure leads to decrease in transition temperature and the calculated pressure coefficient is -0.311 K/GPa . Flux pinning and vortex activation energies also improved with indium addition. Only positive frequencies are observed in phonon dispersion curve that relate to the absence of charge density wave or structural instability in the normal state.

Field of study: Physics
Dynamic digital fluorescence ratio imaging of cell calcium in vascular endothelial cells.

To study the spatial and temporal distribution of intracellular Ca2+ concentration in cultured bovine pulmonary artery endothelial (BPAE) cells.



Cultured BPAE cells were loaded with Fura-2 and observed under an inverted microscope coupled to a microfluorimeter, which enables pixel-to-pixel ratio imaging of the BPAE cells in real time.



Addition of Ca2+ 1-2 mmol.L-1 to BPAE cells, which were exposed to Ca(2+)-free medium containing egtazic acid, resulted in a transient elevation of cytosolic Ca2+ concentration, which rapidly returned to the resting level. Biphasic elevation (a larger transient phase followed by a smaller sustained phase) of intracellular Ca2+ concentration was observed upon the addition of ATP (via activation of surface membrane receptor). 4-Chloro-3-ethyl phenol (CEP; an activator of Ca(2+)-induced Ca2+ channels) potently induced elevation of Ca2+ level. Cyclopiazonic acid (CPA; an inhibitor of endoplasmic reticulum Ca(2+)-ATPase pump) offered a more sustained elevation of Ca2+. In most cases, the highest level of Ca2+ elevation was observed around the cell peripheries, sometimes at rest and particularly upon stimulation. Ca2+ elevation associated with nuclear complex seemed to be higher compared to that in the cytosolic compartment.



Changes of cell Ca2+ upon stimulation by various agents that acted at different intracellular sites were found to be temporarily and spatially heterogenous among BPAE cells. At the single cell level, Ca2+ elevation seemed to occur initially near the peripheral region followed by the nuclear region. This study raised the possibility that nuclear Ca2+ and cytosolic Ca2+ might be regulated independently in BPAE cells.

Field of study: Biology, Chemistry, Medicine
Prediction of soil sorption coefficients using model molecular structures for organic matter and the quantum mechanical COSMO-SAC model.

The soil sorption coefficient, K(OC), is an important property affecting the environmental fate of organic molecules. Difficulties associated with measuring K(OC) have led to many attempts to predict this property, but most rely on empirical descriptors for the soil phase determined from correlations with measured K(OC) data, and are thereby limited by the data quality and diversity. A new method is presented to predict K(OC) for nonionic organic compounds that requires only molecular structures. No calibration is performed. Using model humic acid (HA) and fulvic acid (FA) molecular structures from the literature, the soil organic matter is modeled as an organic solvent composed of HA or FA molecules. K(OC) is predicted as an organic solvent-water partition coefficient using the quantum mechanics-based model COSMO-SAC. The log K(OC) values for a set of 440 diverse, environmentally relevant chemicals are predicted with a root-mean-square error of 0.84-1.08, depending on which model HA or FA is used.

Field of study: Environmental science
Data-aided and blind stochastic gradient algorithms for widely linear MMSE MAI suppression for DS-CDMA

In this paper, three novel stochastic gradient algorithms for adjustment of the widely linear (WL) minimum mean-squared error (MMSE) filter for multiple access interference (MAI) suppression for direct-sequence code-division multiple access (DS-CDMA) are introduced and analyzed. In particular, we derive a data-aided WL least-mean-square (LMS) algorithm, a blind WL minimum-output-energy (MOE) algorithm, and a WL blind LMS (BLMS) algorithm. We give analytical expressions for the steady-state signal-to-interference-plus-noise ratios (SINRs) of the proposed WL algorithms, and we also investigate their speed of convergence. Wherever possible, comparisons with the corresponding linear adaptive algorithms are made. Both analytical considerations and simulations show, in good agreement, the superiority of the novel WL adaptive algorithms. Nevertheless, all proposed WL algorithms require a slightly lower computational complexity than their linear counterparts.

Field of study: Engineering