nils-herrmann/clean_scirepeval huggingface dataset:
Adverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and Withdrawal

Although several chemical structural classes of synthetic cannabinoids (SCs) were recently classified as Schedule I substances, rates of use and cases of serious toxic effects remain high. While case reports and media bring attention to severe SC toxicity, daily SC use resulting in dependence and withdrawal is a significant concern that is often overlooked when discussing the risks of these drugs. There is a rich literature on evidence-based approaches to treating substance use disorders associated with most abused drugs, yet little has been published regarding how to best treat symptoms related to SC dependence given its recency as an emerging clinically significant issue. This review provides a background of the pharmacology of SCs, recent findings of adverse effects associated with both acute intoxication and withdrawal as a consequence of daily use, and treatment approaches that have been implemented to address these issues, with an emphasis on pharmacotherapies for managing detoxification. In order to determine prevalence of use in cannabis smokers, a population at high risk for SC use, we obtained data on demographics of SC users, frequency of use, and adverse effects over a 3.5-year period (2012–2015) in the New York City metropolitan area, a region with a recent history of high SC use. While controlled studies on the physiological and behavioral effects of SCs are lacking, it is clear that risks associated with using these drugs pertain not only to the unpredictable and severe nature of acute intoxication but also to the effects of long-term, chronic use. Recent reports in the literature parallel findings from our survey, indicating that there is a subset of people who use SCs daily. Although withdrawal has not been systematically characterized and effective treatments have yet to be elucidated, some symptom relief has been reported with benzodiazepines and the atypical antipsychotic, quetiapine. Given the continued use and abuse of SCs, empirical studies characterizing (1) SCs acute effects, (2) withdrawal upon cessation of use, and (3) effective treatment strategies for SC use disorder are urgently needed.

Field of study: Medicine, Psychology
Cultural Distance in the Workplace: Differences in Work-Related Attitudes between Vietnamese Employees and Western Employers

In this globalized and internationalized world, intercultural communication at workplaces is a topic often examined. This study aimed to shed light on the cultural differences in work-related values between Western and Vietnamese employers in Vietnam. In total, 94 Western and Vietnamese companies in two areas in the South of Vietnam participated. Questionnaires were completed by 763 Vietnamese employees, 43 Vietnamese employers/managers and 33 Western employers/managers. The findings from the questionnaire data indicate that there are substantial differences in work-related attitudes between Western employers and Vietnamese employees that are related to both cultural differences and position in a company. Sense of time and face-concern are the two prominent differences between Western and Vietnamese professionals. Implications are discussed for further training of Vietnamese prospective graduates so that they can work effectively with Western employers/managers in the future.

Field of study: Business
Possible Relations between General Population Suicide Rates and Societal Crime: A Cross-National Study

Crime may be associated with a less structured society, less social integration, and feelings of less security and greater distress among citizens, which characteristics may lead to mental illness and subsequent suicide. Therefore, a cross-national analysis examining the association of general population suicide rates with percent of males and females in the population victimised by different categories of crime was undertaken using cross-national data from the World Health Organization and United Nations for 42 countries. Spearman correlations were generally weak and not statistically significant. Those values were at variance with the study's hypothesis and may be explained by several factors, including methodological issues. Individual-level case-control or cohort studies of suicides and attempted suicides in the general population may permit exploration of the relation of general population suicides with experience and percent by nations of being victimised by crime.

Field of study: Psychology
Critical Inquiry into Moments of Historical Change: Fostering Broader Understandings of Citizenship

This manuscript explores the power of using inquiry in a second-grade classroom to make students’ understanding of citizenship more complex. It describes an inquiry unit in which students studied primary sources, engaged with fiction and nonfiction children’s literature, and participated in interdisciplinary learning to further understand the Civil Rights Movement and the Underground Railroad. Through their understanding of these powerful historic events they came to new conceptions of what it means to be a good citizen. The paper not only describes the unit and how it played out in the classroom it also explores the tensions between teacher directed and student directed inquiry, the ways in which teachers can, and often must integrate English Language Arts into their inquiry in order to find time for it, and the necessity of trusting both students and teachers in their ability to guide their own learning in community. In addition, it describes ways of discussing racism with young learners in both a historical and contemporary context.

Field of study: Sociology
Pre-Mesozoic Crimea as a continuation of the Dobrogea platform: insights from detrital zircons in Upper Jurassic conglomerates, Mountainous Crimea

U–Pb dating, Hf-isotope, and trace-element studies on two detrital zircon samples from sandstone interlayers in the Upper Jurassic conglomerates of the Southern coast of the Mountainous Crimea provide new information on the primary crystalline complexes from which those conglomerates were sourced. The U–Pb age spectra of studied zircons suggest that they were most likely sourced from the (meta)sedimentary complexes of the Eastern and Western Pontides blocks and the Dobrogea platform. In particular, a close similarity of the Precambrian age spectra with the detrital zircons from Late Neoproterozoic–Late Paleozoic (meta)sedimentary complexes of the Dobrogea block provides strong supporting evidence for the affinity between the Pre-Mesozoic basement of the Crimea and the Dobrogea platform. The zircons in the first sample were recycled through Dobrogea sedimentary complexes and originated from terranes with Amazonia affinities, while zircons in the second sample were recycled through the Taurides and originated from terranes related to northeastern Africa and Arabia. The strong similarity of the Precambrian parts of the age spectra of the Dobrogea complexes and the sample K15-007 suggests a resemblance of the Crimea’s Pre-Mesozoic foundation and the Dobrogea platform. Initial analytical data are provided in Electronic Supplementary Materials A (ESM A). Descriptions of measurement parameters, methodologies, and constants used to process primary analytical data and some processing results are reported in ESM B (Figs. B1–B8). Schemes of locations within Balkans–Anatolia–Black Sea–Caucasus region the crystalline complexes with Jurassic, Triassic, Permian–Carboniferous, as well as Late Neoproterozoic–Cambrian and Ordovician–Devonian ages are in ESM C (Figs. C1, C3–C5).

Field of study: Environmental science
Advances in Semiconductor Detectors for Charged Particle Space Spectrometry

Nuclear semiconductor detectors have been limited in their dynamic range of linearity of pulse height versus energy for charged particle spectrometry because of (1) the depth of the sensitive volume, (2) the thickness of any entrance window, and (3) the noise level of the detector-amplifier system. Consideration has been given to extend the range of sensitivity by increasing the volume of the detector by lithium ion drift compensation and to increase the sensitivity to lower energies by removing any entrance window and reducing the noise level of the detector and the amplifier.

Field of study: Physics
The carrier blocking effect on 850 nm InAlGaAs/AlGaAs vertical-cavity surface-emitting lasers

In this study, the carrier blocking effect on 850 nm InAlGaAs/AlGaAs vertical-cavity surface-emitting layers (VCSELs) was theoretically and experimentally investigated. By means of inserting a high-bandgap electron blocking layer, which was either 10 nm thick Al0.75Ga0.25As or 13 nm thick Al0.9Ga0.1As, on the p-side of a quantum-well active region, the laser output performance was theoretically found to be improved. VCSELs with and without an electron blocking layer were also experimentally demonstrated. It was found that the threshold current was reduced from 1.47 to 1.33 mA and the slope efficiency was increased from 0.37 to 0.53 mW mA −1 by inserting a 10 nm thick Al0.75Ga0.25As electron blocking layer. Also, the device became less sensitive to the device temperature, where the amount of increase in the threshold current at an elevated temperature of 95 ◦ Cw as only 0.27 mA and the slope efficiency dropped by only 24.5%. A peak frequency response of nearly 9 GHz at 5 mA, measured from relative intensity noise (RIN), was obtained in these VCSEL devices.

Field of study: Materials science
Small conductance calcium-activated potassium channels of trout CNS: molecular structure, developmental expression, and partial biophysical characterization.

Two small conductance calcium-activated potassium channels that exhibited amino acid similarity with mammalian SK2 and SK3, respectively, were PCR cloned from the CNS of trout and sequenced. Upon heterologous expression in Sf21 insect cells trout SK2 (termed tSK2) produced a calcium-dependent, voltage-insensitive, and non-inactivating current with a single unit conductance of about 11 pS. This current was half maximally activated by 0.76 microM Ca(2+) and blocked by picomolar concentrations of apamin but not by TEA. Transcripts of both SK-related channels possessed a widespread distribution in the mature brain tissue of trout and outside the nervous system were detectable in muscle tissue as well as in liver. As revealed by RT-PCR analysis transcripts encoding tSK2 and tSK3 channels were early detectable during brain development (stage 30, shortly after hatching).

Field of study: Biology
Paulo Freire Critical Pedagogy and its Implications in Curriculum Planning

This study tries to investigate Paulo Freire critical pedagogy and its implications in curriculum planning. Freire critical pedagogy, which has been influenced by Frankfort School, has introduced a new approach in contemporary educational issues. Freire lays a particular emphasis on the role of critical understanding to remove deprivation and injustice from societies. He also believes that development of an educational plan, which is in line with the redeemer education, can pave the hopeful way for a basic evolution in education. The present study, first reviews the history of Freire critical pedagogy, then it introduces philosophical fundamentals of Freire critical pedagogy, and explains some principles of curriculum planning based on Freire critical pedagogy. There are several important principles in Freire curriculum planning. These include attention to traditional and indigenous context of society, coaches’ and students’ participation in educational plan development, attention to the political position of education in curriculum planning, the role of cultural segments in curriculum planning, and the direct relationship between curriculum planning and economic production process. Also educating adults with focus on giving education to emancipatory people is considered as one of the main priorities of Freire’s curriculum planning.  educational planning, critical pedagogy, emancipatory education, adult education, Paulo Freire

Field of study: Education
Metagenomic analyses reveal no differences in genes involved in cellulose degradation under different tillage treatments.

Incorporation of plant litter is a frequent agricultural practice to increase nutrient availability in soil, and relies heavily on the activity of cellulose-degrading microorganisms. Here we address the question of how different tillage treatments affect soil microbial communities and their cellulose-degrading potential in a long-term agricultural experiment. To identify potential differences in microbial taxonomy and functionality, we generated six soil metagenomes of conventional (CT) and reduced (RT) tillage-treated topsoil samples, which differed in their potential extracellular cellulolytic activity as well as their microbial biomass. Taxonomic analysis of metagenomic data revealed few differences between RT and CT, and a dominance of Proteobacteria and Actinobacteria, whereas eukaryotic phyla were not prevalent. Prediction of cellulolytic enzymes revealed glycoside hydrolase families 1, 3 and 94, auxiliary activity family 8 and carbohydrate-binding module 2 as the most abundant in soil. These were annotated mainly to the phyla of Proteobacteria, Actinobacteria and Bacteroidetes. These results suggest that the observed higher cellulolytic activity in RT soils can be explained by a higher microbial biomass or changed expression levels but not by shifts in the soil microbiome. Overall, this study reveals the stability of soil microbial communities and cellulolytic gene composition under the investigated tillage treatments.

Field of study: Biology, Environmental science
5-ALA/SFC Attenuated Binge Alcohol-Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats.

This study aimed to investigate the protective effect of 5-aminolevulinic acid (5-ALA) and sodium ferrous citrate (SFC) against binge alcohol-induced gut leakiness and inflammatory liver disease in HIV transgenic (TG) rats.



TG rats were treated with 3 consecutive doses of binge ethanol (EtOH) with or without 5-ALA/SFC. Blood and liver tissue samples were collected at 6 hours following the last dose of EtOH.



Compared with the wild-type (WT) rats, the TG rats showed increased sensitivity to alcohol-mediated inflammation, as evidenced by the significantly elevated levels of serum endotoxin, AST, ALT, ED1, and ED2 staining in liver. In contrast, 5-ALA/SFC improved the above biochemical and histochemical profiles. 5-ALA/SFC also attenuated the up-regulated mRNA expression of leptin and CCL2. Furthermore, down-regulated intestinal ZO-1 protein expression was also inhibited by 5-ALA/SFC. Moreover, the expressions of HO-1, HO-2, Sirt1, and related signal transduction molecules in liver were increased by 5-ALA/SFC. These results demonstrated that 5-ALA/SFC treatment ameliorated binge alcohol exposure liver injury in a rat model of HIV-infected patients by reducing macrophage activation and expression of inflammatory cytokines/chemokines, and by inducing HO-1, HO-2, and Sirt1 expression.



Taken together, these findings suggested that treatment with 5-ALA/SFC has a potential therapeutic effect for binge alcohol exposure liver injury in HIV-infected patients.

Field of study: Medicine
Image quality prediction: an aid to the Viking Lander imaging investigation on Mars.

Two Viking spacecraft scheduled to land on Mars in the summer of 1976 will return multispectral panoramas of the Martian surface with resolutions 4 orders of magnitude higher than have been previously obtained and stereo views with resolutions approaching that of the human eye. Mission constraints and uncertainties require a carefully planned imaging investigation that is supported by a computer model of camera response and surface features to aid in diagnosing camera performance, in establishing a preflight imaging strategy, and in rapidly revising this strategy if pictures returned from Mars reveal unfavorable or unanticipated conditions.

Field of study: Physics
Effects of sub-chronic low-level dietary intake of chlordane on rats with cirrhosis of the liver.

Male rats, 60 days old, were treated with chlordane during or after induction of liver cirrhosis with carbon tetrachloride to determine the effect of treatment with chlordane on the response of the rats to the disease. When liver cirrhosis was induced simultaneously with chlordane treatment the disease symptoms were aggravated; the lipid content of the tissue was lowered significantly, growth rate was significantly lower than controls and there was no apparent replacement of damaged liver tissue by liver growth. The cytochrome P450 content of the liver was similar after both treatments. Continuation of the chlordane treatment after termination of the carbon tetrachloride treatment brought about a more rapid recovery from the induced cirrhotic condition. All these responses were to a dose range one tenth the recommended "no effect" level for healthy animals.

Field of study: Agricultural and Food sciences
An Automatic Development Process for Integrated Modular Avionics Software

With the ever-growing avionics functions, the modern avionics architecture is evolving from traditional federated architecture to Integrated Modular Avionics (IMA). ARINC653 is a major industry standard to support partitioning concept introduced in IMA to achieve security isolation between avionics functions with different criticalities. To decrease the complexity and improve the reliability of the design and implementation of IMA-based avionics software, this paper proposes an automatic development process based on Architecture Analysis & Design Language. An automatic model transformation approach from domain-specific models to platform-specific ARINC653 models and safety-critical ARINC653-compliant code generation technology are respectively presented during this process. A simplified multi-task flight application as a case study with preliminary experiment result is given to show the validity of this process .

Field of study: Computer science
A Chronostratigraphic Framework for the Rise of the Ediacaran Macrobiota: New Constraints from Mistaken Point Ecological Reserve, Newfoundland

The Conception and St. John’s Groups of southeastern Newfoundland contain some of the oldest known fossils of the Ediacaran macrobiota. The Mistaken Point Ecological Reserve UNESCO World Heritage Site is an internationally recognized locality for such fossils and hosts early evidence for both total group metazoan body fossils and metazoan-style locomotion. The Mistaken Point Ecological Reserve sedimentary succession includes ∼1500 m of fossil-bearing strata containing numerous dateable volcanogenic horizons, and therefore offers a crucial window into the rise and diversification of early animals. Here we present six stratigraphically coherent radioisotopic ages derived from zircons from volcanic tuffites of the Conception and St. John’s Groups at Mistaken Point Ecological Reserve. The oldest architecturally complex macrofossils, from the upper Drook Formation, have an age of 574.17 ± 0.66 Ma (including tracer calibration and decay constant uncertainties). The youngest rangeomorph fossils from Mistaken Point Ecological Reserve, in the Fermeuse Formation, have a maximum age of 564.13 ± 0.65 Ma. Fossils of the famous “E” Surface are confirmed to be 565.00 ± 0.64 Ma, while exceptionally preserved specimens on the “Brasier” Surface in the Briscal Formation are dated at 567.63 ± 0.66 Ma. We use our new ages to construct an age-depth model for the sedimentary succession, constrain sedimentary accumulation rates, and convert stratigraphic fossil ranges into the time domain to facilitate integration with time-calibrated data from other successions. Combining this age model with compiled stratigraphic ranges for all named macrofossils within the Mistaken Point Ecological Reserve succession, spanning 76 discrete fossil-bearing horizons, enables recognition and interrogation of potential evolutionary signals. Peak taxonomic diversity is recognized within the Mistaken Point and Trepassey Formations, and uniterminal rangeomorphs with undisplayed branching architecture appear several million years before multiterminal, displayed forms. Together, our combined stratigraphic, paleontological, and geochronological approach offers a holistic, time-calibrated record of evolution during the mid–late Ediacaran Period and a framework within which to consider other geochemical, environmental, and evolutionary data sets.

Field of study: Geology
Efficient levels of spatial pyramid representation for local binary patterns

Local binary patterns (LBPs) are a well-known operator that shows the ability for rotation and scale invariant texture classification. A recent extension of this operator is the pyramid transform domain approach on LBPs (PLBP). Obtaining more accuracy by using more pyramid representations is an important result of PLBP, which increases not only feature dimensionality, but also classification computational time (CT). This study illustrates that more pyramid image representations will not improve the performance of the PLBP. We evaluate efficient levels of representation for the PLBP descriptor. In addition, the authors propose some feature selection approaches, such as the multi-level and multi-resolution (ML + MR) approach and the ML, MR and multi-band (ML + MR + MB) approach and discuss their efficiency and CT. Experimental results show that the proposed feature selection approaches improve the accuracy of texture classification with fewer pyramid image representations. In addition, replacing the Chi-2 similarity measurement with Czekannowski improves the accuracy of texture classification.

Field of study: Computer science
Supporting patients with bladder exstrophy and their family: presentation of two tools

The Department of Paediatric Urology of Lyon University Hospitals follows a large cohort of patients with bladder exstrophy / epispadias. In order to help these families to understand the various steps of this treatment and their potential complications, we designed a brochure which tries to answer the main queries often raised by the families and patients: What is bladder exstrophy? How frequent is it? What are the causes? How is the diagnosis performed? What are the various steps of the surgical treatment and their potential problems? What is the outcome in terms of self-confidence, continence, sexuality etc.  This brochure is an excellent support to run the outpatient clinic by Clinical Specialist Nurses (CNS). It is also an essential tool for the Association we created to support French speaking exstrophy patients (APEX: Accompagnement du Patient EXstrophique). We would like to present this brochure to the ESPU Nurse group to get their comments and possibly to generate an ESPUN brochure for these families.  We have previously produced similar brochures for Neuropathic Bladder and Hypospadias with a very positive feed-back from patients, families and GPs.  If we get adequate support, we will create a website which could be a joint venture with ESPU / ESPUN

Field of study: Medicine