nils-herrmann/clean_scirepeval huggingface dataset:
Opposite reaction of ERK and JNK in ischemia vulnerable and resistant regions of hippocampus: involvement of mitochondria.

Delayed ischemic death of neurones is observed selectively in CA1 region of hippocampus at 3-4 days of reperfusion. Signals generated immediately during and after ischemia are further propagated by a variety of kinases, proteases and phosphatases. Tissue samples from dorsal (vulnerable) and abdominal (resistant) parts of gerbil hippocampi were collected to determine the activation state of key signaling molecules: Akt, Raf-1, JNK, ERK1/2 in the course of reperfusion after 5 min of global cerebral ischemia. Western blot analysis of phosphorylated forms of the kinases revealed persistent activation of JNK, being limited mostly to vulnerable CA1 region. On the contrary, activation of ERK, although observed transiently in both parts, was enhanced for a longer time in the abdominal hippocampus. The levels of the active/phosphorylated Akt and Raf-1 kinases did not change significantly during the recovery period. No significant correlation between postischemic JNK activation and c-Jun phosphorylation or its contribution to AP1-like complex formation was found. In contrast, the amount of active JNK linked with mitochondrial membranes was significantly increased and preceded neuronal death in CA1. In the same period of time the AP1 complex, augmented in CA1 region, did not appear to contain a classical c-Fos protein. These results are consistent with the theory that either long-lasting activation of JNK and/or contrasting ERK and JNK activities in critical time of reperfusion, contribute to selective apoptosis of CA1 neurons. This, in connection with the translocation of activated JNK to mitochondria and time/regional differences in AP1 binding protein complexes can affect final postischemic outcome.

Field of study: Biology
High Speed Machining Center and its Application

Machining center is one of the most important e-quipments in modern machine shop.In this paper, the performances of high speed machining center are introduced. The motorized spindle and linear motor used in the machining center are given.The parallel mechanism used in high speed machine tool is analysed. The applications of high speed machining in automobile industry, mould inustry, aeronautic and as-tronautic industries are discussed. Finally, the author makes some suggestions on developing high speed machining centers in China.

Field of study: Engineering
Condensation of 1-Substituted 1,2,3,9a-Tetrahydro-9H-imidazo[1,2-a]indol-2-one Derivatives with Aromatic Aldehydes

Condensation of 1-alkyl-, 1-allyl-, and 1-benzyl-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-ones with benzaldehydes in acetic acid and subsequent treatment of the reaction mixture with potassium hydroxide afforded 1-substituted 9a-(2-phenylethenyl)-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-one derivatives. 1-Methyl- and 1-ethyl-9a-[2-(4-dimethylaminophenyl)ethenyl]-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-ones were synthesized by alkylation of 9a-[2-(4-dimethylaminophenyl)ethenyl]-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-one with methyl- and ethyl iodides in DMF in the presence of a strong base.

Field of study: Chemistry
Wetting patterns for wheel and nonwheel irrigated furrows

Bromide (Br–) masses recovered by extensive sampling of very fine sandy loam soil to a depth of 1.5 m defined the pattern of soil water movement from irrigated furrows. Wheel traffic occurred in alternate furrows. Bromide was applied in the irrigation water in three-wheel and three-nonwheel furrows. All border furrows and furrows between treated furrows were irrigated with untreated water. Small amounts of the bromide tracer moved laterally and vertically throughout the soil profile surrounding wheel furrows. Bromide mass in samples taken directly beneath wheel furrows was as high as 35.5 mg kg–1 of soil, while bromide mass in samples taken beneath adjacent ridges seldom exceeded 8.89 mg kg–1 of soil. These data suggest that water movement from wheel furrows was generally downward, probably because compaction reduced the infiltration rate and also because much of the flow was non-Darcian. The location and amount of bromide surrounding nonwheel furrows at the lower end of the field were similar to wheel furrows, probably because of the relatively short infiltration opportunity times. Only at the upper end of nonwheel furrows, where an average depth of 260 mm of water was infiltrated, was bromide found in quantities large enough to infer substantial lateral movement.

Field of study: Agricultural and Food sciences
Assessment and management of cumulative impacts in California's network of marine protected areas

In response to concerns about human impacts to coastal ecosystems, conservationists and practitioners are increasingly turning to networks of marine protected areas (MPAs). Although MPAs manage for fishing pressure, many species and habitats in MPAs remain exposed to a multitude of stressors, including stressors from global climate change and regional land- and ocean-based activities. To support the adaptive management of MPAs that are subject to multiple interacting stressors, coastal managers need to understand the potential impacts from other single and multiple stressors. To demonstrate how this can be done, we quantify and map cumulative impacts resulting from multiple stressors to California's network of MPAs, using a widely available cumulative impacts mapping tool. Among individual stressors, those related to climate, including ocean acidification, UV radiation increases, and SST anomalies, were found to have the most intense impacts, especially on surface waters and in the rocky intertidal. Climate stressors are challenging to limit at the local MPA scale, but intense land- and ocean-based impacts that were found to affect a majority of MPAs, such as sediment increases, invasive species, organic pollutants and pollution from shipping and ports, may be more easily regulated at a regional or local scale. This is especially relevant for South and Central coast MPAs where these impacts are the greatest on beaches, tidal flats, and coastal marshes. Accounting for cumulative impacts from these and other stressors when developing monitoring and management plans in California and across the world, would help to improve the efficacy of MPAs.

Field of study: Environmental science
Key anatomic findings on fetal ultrasound and MRI in the prenatal diagnosis of bladder and cloacal exstrophy.

Prenatal determination of bladder exstrophy (BE) or cloacal exstrophy (CE), known also as the omphalocele-exstrophy-imperforate anus-spinal anomaly complex (OEIS), is challenging. Distinguishing between BE and CE is important because children with CE have many more challenges initially and during their lifetime. An accurate diagnosis is critical when counselling expectant parents. We hypothesized that there are key imaging features that can distinguish BE from CE, and that there are areas of diagnostic concordance and discordance between fetal ultrasound (fUS) and fetal MRI (fMRI) among these entities.



We queried a single institutional IRB-approved registry of children with BE and CE to identify those with accessible fetal imaging from 2000 to 2018, and formal interpretations were collected. Two pediatric radiologists performed independent retrospective blinded review of the images. Criteria evaluated included: genitalia, kidneys, bowel appearance, presence of anal dimple, location of insertion of umbilical cord into the abdomen relative to the abdominal wall defect, umbilical vessels, bladder protuberance, presence of omphalocele, and spine/neural cord abnormalities. We evaluated concordance between radiologic interpretations and postnatal diagnosis, as well as between specific findings in the two diagnostic modalities.



Twenty-one infants born between 2000 and 2018 with BE or CE had fetal imaging for review: 15 had both fUS and fMRI, 2 had fUS alone, and 4 fMRI alone. There was 100% concordance between fUS and fMRI in evaluating kidneys, presence of anal dimple, location of abdominal insertion of umbilical cord relative to the defect, number of umbilical vessels, and spine abnormalities/level of neural cord termination. The following discrepancies were observed: 1) genitalia and bowel appearance, and bladder protuberance in 1/15 (6.7%); 2) presence of an omphalocele in 2/15 (13.3%). Of the initial radiologic interpretations, 4/17 (23.5%) of fUS and 2/19 (10.5%) of fMRI erroneously were interpreted as on the OEIS spectrum when the post-natal diagnosis was BE. Errors in diagnosis were due to a protuberant bladder plate extending beyond the plane of the abdominal wall with bowel loops posteriorly mimicking an omphalocele. In all of these BE cases, the abdominal wall defect was located inferior to the umbilical cord insertion on the abdominal wall.



An everting bladder plate with bowel loops posterior to the plate in classic BE may be misdiagnosed as CE. Identification of the location of umbilical cord insertion relative to the abdominal wall defect, with fetal US or MRI, results in the correct differentiation between BE and CE.

Field of study: Medicine
The Genesis and Internal Dynamics of El Salvador's People's Revolutionary Army, 1970–1976

Using interviews with former militants and previously unpublished documents, this article traces the genesis and internal dynamics of the Ejército Revolucionario del Pueblo (People’s Revolutionary Army, ERP) in El Salvador during the early years of its existence (–). This period was marked by the inability of the ERP to maintain internal coherence or any consensus on revolutionary strategy, which led to a series of splits and internal fights over control of the organisation. The evidence marshalled in this case study sheds new light on the origins of the armed Salvadorean Left and thus contributes to a wider understanding of the processes of formation and internal dynamics of armed left-wing groups that emerged from the s onwards in Latin America.

Field of study: Political science
Intrapersonal and Familial Effects of Child Sexual Abuse on Female Partners of Male Survivors.

Intrapersonal and familial effects of childhood sexual abuse (CSA) were investigated by interviewing 10 female partners of male survivors. Consensual qualitative research analysis (C. Hill, B. Thompson, & E. Nutt Williams, 1997) yielded 13 domains describing male partner, female partner, couple, and family functioning. Findings concerning emotional reactions, coping strategies, communication patterns, and sexual functioning correspond to the 3 components of C. Maltas and J. Shay's (1995) trauma contagion model (i.e., threatened beliefs, chronic stress, and reenactment of aspects of CSA). Additional findings suggest themes of recovery from trauma contagion. Whereas results concerning threatened beliefs and chronic stress may replicate to other populations (e.g., partners of war veterans), reenactment of aspects of CSA seems unique. Practice and research recommendations are presented.

Field of study: Psychology
Research on the Improvement Effect and Mechanism of Micro-Scale Structures Treated by Laser Micro-Engraving on 7075 Al Alloy Tribological Properties

During various applications in aerospace, ships, autos, and aircraft, 7075 Al alloy will frequently contact other materials, and therefore suffer from slight abrasion. However, the poor tribological properties of 7075 Al alloy greatly affect its performance and life length, leading to limitations in its application. Preparing roughness structures on the surface is regarded as a promising method to improve the properties of materials. However, the tribological properties of 7075 Al alloy cannot be enhanced significantly by roughness structures in complex dynamic changeable environments, owing to the incomplete understanding of the effect of roughness structures. Given the above issues, in this paper, micro-scale structures (linear grooves, gridding grooves, and arc grooves) were designed and prepared on 7075 Al alloy surfaces by a surface treatment (laser micro-engraving), which provides excellent controllability of the morphology and dimensions of as-prepared roughness structures. The tribological properties of the as-prepared surfaces were investigated systemically. The effect of micro-scale structures on the tribological properties was studied. The wear mechanism and tribological properties improvement mechanism of the surfaces were clarified. Furthermore, the effect degree of the enhancement factors of the micro-scale structures on the tribological properties was explored under different conditions. The results indicate that the micro-scale structures play an important role in improving the tribological properties of Al alloy under different sliding speeds. The improvement mechanism can be summarized by four factors. However, the effect degrees of these factors on the tribological properties exhibit considerable differences. This study not only develops specific micro-scale structures that can dramatically improve the tribological properties of 7075 Al alloy under different conditions, but also offers guidance for the construction of appropriate roughness structures that can dramatically improve the tribological properties of Al alloy according to the friction conditions.

Field of study: Materials science
Plant–arthropod associations from the Siwalik forests (middle Miocene) of Darjeeling sub-Himalaya, India

Fossil leaves from the Siwalik sedimentary rocks of Darjeeling sub-Himalaya, evidence a variety of plant–insect interactions that operated during the evolution of monsoon-influenced forests from middle Miocene times. We assessed the diversity and frequency of insect herbivory on 137 specimens representing the Darjeeling lower Siwalik flora (DLSF). We also examined the percent of leaf area removed by herbivory as an independent measure of the effect of insect herbivore removal of host plant photosynthetic tissue. Five functional feeding groups (FFGs) are identified in this study namely leaf mining, hole feeding, skeletonizing, galling and margin feeding. These traces indicate that insects interacted with the plants for various purposes, including feeding, egg laying and sheltering. Furthermore, these morphotraces tend to suggest similarities in insect interactions with leaves of extant plant species such as Persea, Woodfordia, Shorea, Artocarpus, Callicarpa, Albizia, Lagerstroemia etc. On the basis of comparison with extant taxa, possible leaf feeders could have belonged to the insect orders Orthoptera, Coleoptera, Lepidoptera and Diptera. Although the morphology of the phytophagous insects associated with the fossil leaves is unknown, present findings reveal that many modern plant–insect relationships were established by the Miocene time and continue to the present, shaping both the present day flora and fauna. In the present study we compare insect herbivory at DLSF to that of our previously investigated Arunachal lower Siwalik flora and two younger floras from that area. We note a similar range of FFGs and damage types observed among these four fossil floras and conclude that compared to biotic factors climate had little influence in determining the evolution of plant-insect interactions in the eastern Himalayan region.

Field of study: Environmental science, Geography
Direct modulatory effect of C‐reactive protein on primary human monocyte adhesion to human endothelial cells

C‐reactive protein (CRP) is the prototypic acute phase serum protein in humans. The effects of CRP on primary human monocyte adhesion molecule expression and interaction with the endothelium have not been studied. Herein, we describe an investigation into the phenotypic and functional consequences of CRP binding to peripheral blood monocytes ex vivo. Peripheral whole blood was collected from healthy, non‐smoking males. Mononuclear cells (MNC) and monocytes were isolated by differential centrifugation using lymphoprep and Dynal negative isolation kit, respectively. Cells were exposed to CRP from 0 to 250 µg/ml for 0–60 min at 37°C and analysed for (a) CD11b, PECAM‐1 (CD31) and CD32 expression by flow cytometry and (b) adhesion to LPS (1 µg/ml; 0–24 h) treated human umbilical vein endothelial cells (HUVEC). CD14+ monocyte expression of CD11b increased significantly up to twofold when exposed to CRP, compared to controls. There was no significant difference in CD32 expression, whereas CD31 expression decreased after exposure to CRP. CRP treatment of monocytes inhibited their adhesion to early LPS‐activated HUVEC (0–5 h). However, the adhesion of CRP‐treated monocytes to HUVEC was significantly greater to late activation antigens on HUVEC (24 h, LPS) compared to controls. We have shown that CRP can affect monocyte activation ex vivo and induce phenotypic changes that result in an altered recruitment to endothelial cells. This study provides the first evidence for a further role for C‐reactive protein in both monocyte activation and adhesion, which may be of importance during an inflammatory event.

Field of study: Biology, Medicine
Government Information Public Impact of Economic Growth

The era of information economy, benign information resources is scarce resources, information socio-economic activities is the most active factor. Information from the economics point of view, the transition economies in government information on the economic characteristics, economic function, pointed out that market imperfections and market information asymmetry, and the importance of open information market, namely the role of economic growth, And the unlimited demand for scarce resources of the conflict, through the allocation of resources and achieve the greatest meet the demand.

Field of study: Business
Changes of dung beetle communities from rainforests towards agroforestry systems and annual cultures in Sulawesi (Indonesia)

Little is known about how tropical land-use systems contribute to the conservation of functionally important insect groups, including dung beetles. In a study at the margin of Lore Lindu National Park (a biodiversity hotspot in Central Sulawesi, Indonesia) dung-beetle communities were sampled in natural forest, young secondary forest, agroforestry systems (cacao plantations with shade trees) and annual cultures (maize fields), each with four replicates (n = 16 sites). At each site we used 10 pitfall traps, baited with cattle dung, along a 100 m transect for six 3-day periods. The number of trapped specimens and species richness at the natural forest sites was higher than in all land-use systems, which did not significantly differ. Each land-use system contained, on average, 75% of the species richness of the natural forest, thereby indicating their importance for conservation. However, a two-dimensional scaling plot based on NESS indices (m = 6) indicated distinct dung beetle communities for both forest types, while agroforestry systems and annual cultures exhibited a pronounced overlap. Mean body size of dung beetles was not significantly influenced by land-use intensity. Five of the six most abundant dung beetle species were recorded in all habitats, whereas the abundance of five other species was significantly related to habitat type. Mean local abundance and number of occupied sites were closely correlated, further indicating little habitat specialisation. The low dung beetle diversity (total of 18 recorded species) may be due to the absence of larger mammals in Sulawesi during historical times, even though Sulawesi is the largest island of Wallacea. In conclusion, the dung beetle fauna of the lower montane forest zone in Central Sulawesi appears to be relatively robust to man-made habitat changes and the majority of species did not exhibit strong habitat preferences.

Field of study: Environmental science
An enhanced information server for seamless vertical handover in IEEE 802.21 MIH networks

Seamless vertical handover is a key requirement in heterogeneous wireless networks where different networks are integrated. In this paper, we introduce an enhanced information server (EIS) to accelerate vertical handover procedures in IEEE 802.21 media independent handover (MIH) networks. Based on the EIS, we propose an improved vertical handover procedure in which wireless channel conditions are estimated by exploiting spatial and temporal locality at the EIS, and therefore time consuming channel scanning procedures can be skipped. Simulation results demonstrate that the proposed scheme can reduce the vertical handover latency under diverse environments.

Field of study: Computer science
Cervical spine deformity associated with resection of spinal cord tumors.

Postoperative sagittal-plane cervical spine deformities are a concern when laminectomy is performed for tumor resection in the spinal cord. These deformities appear to occur more commonly after resection of intramedullary spinal cord lesions, compared with laminectomy for stenosis caused by degenerative spinal conditions. Postlaminectomy deformities are most common in pediatric patients with an immature skeletal system, but are also more common in young adults (< 25 years of age) in comparison with older adults. The extent of laminectomy and facetectomy, number of laminae removed, location of laminectomy, preoperative loss of lordosis, and postoperative radiation therapy in the spine have all been reported to influence the risk of postlaminectomy spinal deformities. When these occur, patients should be monitored closely with serial imaging studies, because a significant percentage will have progressive deformities. These can range from focal kyphosis to more complicated swan-neck deformities. General indications for surgical intervention include progressive deformity, axial pain in the area, and neurological symptoms attributable to the deformity. Surgical options include anterior, posterior, and combined anterior-posterior procedures. The authors have reviewed the literature on postlaminectomy kyphosis as it relates to resection of cervical spinal cord tumors, and they summarize some general factors to consider when treating these patients.

Field of study: Medicine
Of Dialectics and Goat's Blood in an Anecdote by Montaigne

N his essay 'De la ressemblance des enfants aux peres' (II, 37) Montaigne tells two stories, the second of which is the curious account of how, after hearing that goat's blood was good for one's health, he raised a billy goat and had it slaughtered in the hope of procuring for himself some of this marvelous elixir. Only after the animal had been killed did he begin to have doubts about the medicinal virtues of goat's blood. Amused by his earlier credulousness, Montaigne relates this anecdote in a tone so personal, so affable and self-deprecatory that the reader, won over by the amiability of the speaker, is likely to be sensitive to the human quality of the narrator but unlikely to be attentive to the subtle way in which the text determines his responses or to the author's ulterior motives for eliciting those very responses. By plotting the reader's reaction to this anecdote, by charting the path that Montaigne has carefully laid out so as to lead the reader to the desired conclusion, we can see, I believe, the use that Montaigne makes of dialectics, one of the most important strategies to which he resorts when he wishes to debunk an idea. The anecdote begins as follows:

Field of study: History