nils-herrmann/clean_scirepeval huggingface dataset:
Short chain acyl CoA dehydrogenase deficiency and short term high fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid handling in liver
Venue: Nutrition Metabolism

BackgroundThe liver is an important site of fat oxidation, which participates in the metabolic regulation of food intake. We showed previously that mice with genetically inactivated Acads, encoding short chain acyl CoA dehydrogenase (SCAD) shift food consumption away from fat and toward carbohydrate when tested in a macronutrient choice paradigm. This phenotypic eating behavior suggests a link between fat oxidation and nutrient choice which may involve an energy sensing mechanism. To identify hepatic processes that could trigger energy related signals, we have now performed transcriptional, metabolite and physiological analyses in Acads mice following short term (2 days) exposure to either high or low fat diet.Methods and ResultsMetabolite analysis revealed 25 acylcarnitine species that were altered by diet and/or genotype. Compared to wild type mice, phosphorylated AMP activated protein kinase was 40 higher in Acads mice after short term high fat diet, indicating a low ATP/AMP ratio. Metabolite analyses in isolated liver mitochondria from Acads mice during ADP linked respiration on butyrate demonstrated a reduced oxygen consumption rate (OCR) compared to wild type, an effect that was not observed with succinate or palmitoylcarnitine substrates. Liver transcriptomic responses in Acads mice fed high vs. lowfat diet revealed increased RXR/PPARA signaling, up regulation of lipid handling pathways (including beta and omega oxidation) and increased mRNA expression of Nfe2l2 target genes.ConclusionsTogether, these results point to an oxidative shortage in this genetic model and support the hypothesis of a lower hepatic energy state associated with SCAD deficiency and high fat diet.
Rebuttal to "Photonic Microwave Generation With Frequency Octupling Based on a DP QPSK Modulator"
Venue: IEEE Photonics Technology Letters

In the title paper, Gao et al. have experimentally demonstrated a scheme for filter less photonic millimetre wave (mm wave) generation using a dual polarization quadrature phase shift keying modulator (DP QPSK) For frequency octo tupling generation, the X QPSK modulator is biased such that all the harmonics are suppressed except those that are order of 4l, where l is an integer and combined with the output of the non modulated Y QPSK modulator using a polarization beam combiner. Precise setting of the polarizer angle suppresses the carrier, leaving the 4th sidebands as the strongest harmonics, which is the innovative part of their design. However, a demerit of the design is that, following any change in modulation index, a precise readjustment of the polarizer angle is required in order to suppress the unwanted harmonics (e.g. carrier) without undue suppression of the wanted harmonics. The goal of this comment is to show that, for an appropriate modulation of the Y QPSK modulator with the design presented by Gao for a fixed polarizer angle, all the harmonics can be suppressed except those that are order of 4l, where l is an odd integer. Hence, a filter less frequency octo tupling can be generated without restricting its operation by the careful adjustment of the RF drive signal; rather the circuit can function for a broad range of modulation index (m 2.5 7.25) Moreover, the unwanted harmonics suppressed by design mandate 6.66 dB optical and 11 dB electrical advantages over the design presented by Gao and the precise setting of the polarizer angle can be avoided.
Effects of different irrigation regimes on a super high density olive grove cv. "Arbequina" vegetative growth, productivity and polyphenol content of the oil
Venue: Irrigation Science

The effects of multiple irrigation regimes on the relationships among tree water status, vegetative growth and productivity within a super high density (SHD) "Arbequina" olive grove (1950 tree/ha) were studied for three seasons (2008 2010) Five different irrigation levels calculated as percentage of crop irrigation requirement using FAO procedures (Allen et al. in Crop evapotranspiration. Guidelines for computing crop water requirements. Irrigation and drainage paper 56. FAO, Rome, 1998) were imposed during the growing season. Periodically during the growing season, daytime stem water potential (PsSTEM) inflorescences per branch, fruits per inflorescence and shoot absolute growth rate were measured. Crop yield, fruit average fresh weight and oil polyphenol content were measured after harvest. The midday PsSTEM ranged from 7 to 1.5 MPa and correlated well enough with yield efficiency, crop density and fruit fresh weight to demonstrate its utility as a precise method for determining water status in SHD olive orchards. The relationships between midday PsSTEM and the horticultural parameters suggest maintaining PsSTEM values between 3.5 and 2.5 MPa is optimal for moderate annual yields of good quality oil. Values below 3.5 MPa reduced current season productivity, while values over 2.5 MPa were less effective in increasing productivity, reduced oil quality and produced excessive crop set that strongly affected vegetative growth and fruit production the following season. On the basis of the result given here, irrigation scheduling in the new SHD orchards should be planned on a 2 year basis and corrected annually based on crop load. Collectively, these results suggest that deficit irrigation management is a viable strategy for SHD olive orchards.
Post Craniotomy Pain Management: Beyond Opioids
Venue: Current Neurology and Neuroscience Reports

Craniotomy pain may be severe and is often undertreated. Pain management following craniotomy is a balancing act of achieving adequate analgesia but avoiding sedation, respiratory depression, hypercapnia, nausea and vomiting, and hypertension. Opioids are a first line analgesic therapy; however, concern that opioid related adverse effects (sedation, respiratory depression) may interfere with neurologic assessment and increase intracranial pressure has limited use of these drugs for intracranial surgery. Non opioid analgesics avoid these effects and may be useful as part of a multimodal regimen for post craniotomy pain. Regional scalp blocks, paracetamol, and non steroidal anti inflammatory drugs are beneficial in the early post operative period. Recent studies suggest a role for novel analgesics: dexmedetomidine, gabapentinoids, and ketamine, though additional studies are necessary.
Generation and real time implementation of high speed controlled maneuvers using an autonomous 19 gram quadrotor
Venue: 2016 IEEE International Conference on Robotics and Automation (ICRA)

We present a new experimental method for the generation and real time implementation of high speed aerobatic maneuvers, including multiple flips, on a 19 gram autonomous quadrotor. A key element in the proposed approach is the design and experimental tuning of a gain scheduling control strategy in which two linear time invariant (LTI) controllers are alternatingly activated and deactivated to switch between a normal flight mode and an aerobatic mode, enabling the flyer to perform consecutive multiple flips in a robustly stable manner. The implementation of the controllers is done using on board power, sensors and computing capabilities, so that the quadrotor remains fully autonomous during flight. Notably, the attainment of autonomy, using real time control, is made possible by the development of a new method for speed planning based on cubic functions, the geometric generalization of the notion of multi flip and the empirical identification of the flyer's dynamics, required for trajectory generation and controller synthesis. Compelling experimental results demonstrate the suitability of the proposed approach. In particular, we present maneuvers that include consecutive single, double, and triple flips about the flyer's roll principal axis and a non principal axis. To the best of our knowledge, to this date, the flyer used in this research is the smallest controlled quadrotor to have autonomously accomplished three consecutive flips while remaining stable.
ANALISIS ACTIVITY BASED COSTING SYSTEM (ABC SYSTEM) SEBAGAI DASAR MENENTUKAN HARGA POKOK KAMAR HOTEL (Studi Kasus pada Hotel Selecta Kota Batu Tahun 2014)

The enterprise can implement Activity Based Costing System (ABC System) to determine the cost of the base or service price. This method is used to make a good decision regarding the cost of the base or service price in the hotel's diversity in providing products or services. This study is aim to determine the calculation and the differences of the base price of renting the hotel's room in Selecta Hotel (traditionally) and the calculation by using abc system. The results showed there were some differences between the method applied by Selecta Hotel and ABC System. Based on the result of calculations, there were differences between a lower price (undercosting) for six types of rooms namely Family, Deluxe, Superior, Executive, Suite and Exclusive type which were Rp 225.007,15, Rp 218.510,72, Rp 292.523,33, Rp 66.426,15, Rp 250.638,78, and Rp 132.460,68. While the two types of rooms had a higher price (overcosting) Cottage I and Cottage VII type. They are Rp 857,601.79 and Rp.  Keyword: base price of the hotel rooms, the ABC system ABSTRAK Perusahaan jasa dalam menentukan harga pokok produk atau jasa menerapkan metode Activity Based Costing System ABC System agar perusahaan tidak salah dalam pengambilan keputusan mengenai harga pokok produk atau jasa dimana hotel memiliki keanekaragaman dalam menyediakan produk atau jasa. Penelitian ini bertujuan untuk mengetahui perhitungan harga pokok sewa kamar hotel menurut Hotel Selecta (tradisional) dan perhitungan menggunakan ABC System serta mengetahui perbedaan dalam perhitungan antara harga pokok sewa kamar yang telah ditetapkan oleh Hotel Selecta (tradisional) dengan perhitungan ABC System Hasil penelitian menunjukkan terdapat perbedaan antara metode yang diterapkan oleh Hotel Selecta dengan ABC System terjadi selisih harga lebih rendah undercosting untuk enam tipe kamar yaitu tipe Family, Deluxe, Superior, Executive, Suite, dan Exclusive yang masing masing selisihnya yaitu Rp 225.007,15, Rp 218.510,72, Rp 292.523,33, Rp 66.426,15, Rp 250.638,78, dan Rp 132.460,68. Sedangkan dua tipe kamar mempunyai selisih harga lebih tinggi overcosting yaitu tipe Cottage I dan Cottage VII dengan selisih sebesar Rp 857.601,79 dan Rp 171.568,28. Kata kunci harga pokok kamar hotel, ABC system
Results Based Costing (RBC) System: Questioning the Unit of Analysis in ABC

This paper aims to introduce Results Based Costing (RBC) System as an alternative accounting tool by questioning the unit of analysis in ABC. By focusing on 'Results' instead of 'Activities' it investigates its manifest and underlying agendas as a newly innovative idea, with a view to determining its degree of cost management focus and Results Based Management (RBM) Adoption of ABC in different countries especially developed countries has not fulfilled early expectations. Its influence on organizational performance, depending upon how successful performance is defined, has not been evident (see Langfield Smith 2008) The study thus uses historical and website analysis methodologies for investigating innovative diffusion philosophies related to ABC practices and discourse. These are examined through the theoretical lenses of institutional logics theories. It thus distinguishes between institutional logics and situated logics, and their variances. ABC implementation can be characterized as an encounter between the ABC's inscribed institutional logic and the situated institutional logic that is embedded in the existing practices in a given organization. The paper moves on to consider the surrounding emergence of RBM approach and then introduces RBC as new accounting tool along with its developments, its processes, intentions and claimed advantages. RBC's dominant agenda are overhead cost reduction, cost management, performance management and results orientation. Accounting research into the management accounting system and its processes is much needed. This has been largely neglected in favor of management accounting change and innovative diffusion literature. In a world dominated by IT industries, RBC system as a center of organizational and accounting management merits greater attention by researchers. Practitioners in this way can better design and implement systems that build on past knowledge and learning. This study thus presents itself as a first study about RBC currently available in the accounting and management research literatures. It also represents one of the very few referred studies of the Results Based Accounting in the accounting research literature globally.
ANALISIS ACTIVITY BASED COSTING SYSTEM DALAM MENENTUKAN HARGA JUAL PRODUK

Abstrak. Analisis Activity Based Costing System dalam Menentukan Harga Jual Produk. Tujuan penelitian ini Untuk mengetahui perhitungan beban pokok produksi dengan sistem Activity Based Costing (ABC) dalam menentukan harga jual produk dan menunjukkan perbedaaanya dengan sistem tradisional. Proses analisis data yaitu mengidentifikasi aktivitas, menentukan biaya yang terkait dengan masing masing aktivitas, mengelompokkan aktivitas, menggabungkan biaya aktivitas, menghitung Tarif per kelompok aktivitas. Tahap kedua membebankan aktivitas ke produk. Setelah itu menghitung harga jual dengan menggunakan konsep biaya total.Dari perhitungan beban pokok produk dan harga jual terdapat perbedaan jumlah yang diperoleh antara sistem ABC dan sistem Tradisional. Perbedaan itu disebabkan karena dalam tradisional hanya menggunakan cost driver jam mesin, sedangkan ABC menggunakan cost driver unit produksi, pemakaian bahan baku, jam kerja langsung, luas bangunan dan jam mesin. Dengan menggunakan ABC dapat memperbaiki perhitungan beban pokok produk dalam menentukan harga jual.  Activity Based Costing System, Tradisional Costing, Harga Jual Abstract. Activity Based Costing System Analysis in Determining Product Selling Price. The purpose of this study To determine the calculation of the cost of production with the system Activity Based Costing (ABC) in determining the selling price of the product and show perbedaaanya with traditional systems. The process of data analysis is to identify activities, determine the costs associated with each activity, classify activities, combine activity costs, calculate the Rate per activity group. The second stage imposes activity on the product. After that calculate the selling price by using the concept of total cost. From the calculation of the cost of goods sold and the selling price there is a difference in the amount obtained between the ABC system and Traditional system. The difference is because in traditional use only cost driver clock machine, while ABC using cost driver of production unit, use of raw materials, direct working hours, building area and machine hours. By using ABC can improve the calculation of product cost in determining the selling price.  Activity Based Costing System, Traditional Costing, Selling Price
Reasons behind the non application of the activity based costing system in developing countries, case of Lebanon

The Activity Based Costing (ABC) system, despite its spread in the developed countries and the recognition of its importance in the developing countries, is not adopted in the service industry in Lebanon while costing output. With the service industry contributing to more than seventy percent of the GDP in Lebanon, this makes it a subject of interest to justify the non application of the ABC system in this sector. In this study, the authors seek to examine the reasons behind the reluctance of decision makers from applying the ABC system from the following perspectives: the lack of training of employees and the management's support, the top management's perception of the system's high consumption of time and financial resources, the difficulty of collecting data, and the necessity to change the internal culture and the commitment of controllers. The study relies on prior research undertaken on this topic in different countries. A sample of 50 respondents from different service industries like banking, auditing, education and insurance provided the data of this study through answering the questionnaires and interviews. Two questionnaires are used; the first distributed to ABC system users and the second for non ABC users, also five interviews are conducted with senior level managers. The questionnaires are self administered in order to increase the response rate, given the fact that the direct contact in the Lebanese culture proves to generate more efficient and effective data than the indirect contact. Hypotheses are developed stating the most significant reasons that are tested through survey and interviews. The data collected elaborates the companies' point of view regarding the implementation of the ABC system as well as the employees' and management's personal opinions about it. The data is analyzed using the SPSS program and the results reveal that the real factors prohibiting the application of the ABC system are the lack of commitment of controllers and employees, the necessity to change the internal culture, the availability of financial and time resources and the satisfaction with the current costing system. The employees' knowledge and training are not major obstacles in implementing the ABC, similarly for the difficulty in data collection about cost drivers. Other factors for this non application appear to be the priorities of companies in other considerations, and the lack of technology. The outcome of the study provides a vital insight into the reasons behind such lag in the adoption of the ABC system in developing countries like Lebanon.
Pulmonary Nodule Detection in CT Images: False Positive Reduction Using Multi View Convolutional Networks
Venue: IEEE Transactions on Medical Imaging

We propose a novel Computer Aided Detection (CAD) system for pulmonary nodules using multi view convolutional networks (ConvNets) for which discriminative features are automatically learnt from the training data. The network is fed with nodule candidates obtained by combining three candidate detectors specifically designed for solid, subsolid, and large nodules. For each candidate, a set of 2 D patches from differently oriented planes is extracted. The proposed architecture comprises multiple streams of 2 D ConvNets, for which the outputs are combined using a dedicated fusion method to get the final classification. Data augmentation and dropout are applied to avoid overfitting. On 888 scans of the publicly available LIDC IDRI dataset, our method reaches high detection sensitivities of 85.4% and 90.1% at 1 and 4 false positives per scan, respectively. An additional evaluation on independent datasets from the ANODE09 challenge and DLCST is performed. We showed that the proposed multi view ConvNets is highly suited to be used for false positive reduction of a CAD system.
Hyaluronic acid for anticancer drug and nucleic acid delivery.
Venue: Advanced drug delivery reviews

Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible, biodegradable, non toxic, and non immunogenic; moreover, HA receptors are overexpressed on many tumor cells. Exploiting this ligand receptor interaction, the use of HA is now a rapidly growing platform for targeting CD44 overexpressing cells, to improve anticancer therapies. The rationale underlying approaches, chemical strategies, and recent advances in the use of HA to design drug carriers for delivering anticancer agents, are reviewed. Comprehensive descriptions are given of HA based drug conjugates, particulate carriers (micelles, liposomes, nanoparticles, microparticles) inorganic nanostructures, and hydrogels, with particular emphasis on reports of preclinical/clinical results.
Prenatal Maternal Smoking and Increased Risk for Tourette Syndrome and Chronic Tic Disorders.
Venue: Journal of the American Academy of Child and Adolescent Psychiatry

We assessed the role of prenatal maternal smoking in risk for Tourette syndrome and chronic tic disorder (TS/CT) and pediatric onset obsessive compulsive disorder (OCD) METHOD In an analysis of 73,073 singleton pregnancies from the Danish National Birth Cohort, we calculated incidence rates (IR) per 1,000 person year for TS/CT and OCD. We then determined crude and adjusted hazard ratios and 95% CIs associated with prenatal maternal smoking, considering smoking as a dichotomous (yes/no) variable or a stratified variable (no smoking, light smoking, and heavy smoking =10 cigarettes/day] Additional analyses examined the effect of maternal smoking on risk for TS/CT with other comorbid psychiatric conditions.  In final adjusted analyses, heavy smoking was associated with a 66% increased risk for TS/CT (adjusted hazard ratio 1.66, 95% CI 1.17 2.35) In addition, heavy smoking was associated with a 2 fold increased risk for TS/CT with comorbid attention deficit/hyperactivity disorder (ADHD) and both light and heavy smoking were associated with a more than 2 fold increased risk for TS/CT with any non ADHD psychiatric comorbidity. Our parallel analyses of pediatric onset OCD were likely underpowered but showed similar relationships.  Prenatal maternal smoking was associated with increased risk for TS/CT as well as TS/CT with comorbid psychiatric conditions, even after adjustment for several important variables, including maternal psychiatric history, socioeconomic status, and partner smoking. Our findings point to a pathway linking prenatal tobacco exposure and altered brain development to TS/CT.
Cigarette smoking has no pro cognitive effect in subjects with obsessive compulsive disorder: A preliminary study.
Venue: Psychiatria Danubina

The prevalence of cigarette smoking in patients with different psychiatric disorders is higher than that in the general population, which is partly explained by the pro cognitive effect of smoking on cognitive functions. In subjects with obsessive compulsive disorder (OCD) the prevalence of smokers is lower than that in other psychiatric disorders. We hypothesized that cigarette smoking does not provide benefits and even worsen cognitive performance in OCD.  We compared different executive function subdomains in 20 smoking and 20 non smoking inpatients with OCD. At the beginning of hospitalization, we assessed visuo spatial working memory, planning and set shifting abilities (Cambridge Neuropsychological Test Automated Battery) smoking habits (standardized personal interviews) and the severity of obsessive compulsive symptoms (Dimensional Yale Brown Obsessive Compulsive Scale) RESULTS The performance of smokers and non smokers did not differ significantly in any cognitive subdomain. The smoking duration was significantly associated with poorer visuo spatial working memory performance (P=0.001) CONCLUSIONS Our results showed that cigarette smoking did not provide cognitive enhancement across various executive function subdomains in subjects with OCD. The lack of beneficial cognitive effects of smoking may make these subjects less prone to smoking and may partially explain the lower rate of smokers in OCD compared with other psychiatric conditions.