nils-herrmann/clean_scirepeval huggingface dataset:
Genomic Profiling of Large Cell Neuroendocrine Carcinoma of the Lung
Venue: Clinical Cancer Research

Although large cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small cell lung cancer (SCLC) little is known about its molecular features. We analyzed lung LCNECs to identify biologically relevant genomic alterations.  We performed targeted capture sequencing of all the coding exons of 244 cancer related genes on 78 LCNEC samples [65 surgically resected cases, including 10 LCNECs combined with non small cell lung cancer (NSCLC) types analyzed separately, and biopsies of 13 advanced cases] Frequencies of genetic alterations were compared with those of 141 SCLCs (50 surgically resected cases and biopsies of 91 advanced cases)  We found a relatively high prevalence of inactivating mutations in TP53 (71% and RB1 (26% but the mutation frequency in RB1 was lower than that in SCLCs (40% P 0.039) In addition, genetic alterations in the PI3K/AKT/mTOR pathway were detected in 12 (15% of the tumors: PIK3CA 3% PTEN 4% AKT2 4% RICTOR 5% and mTOR 1% Other activating alterations were detected in KRAS (6% FGFR1 (5% KIT (4% ERBB2 (4% HRAS (1% and EGFR (1% Five of 10 cases of LCNECs combined with NSCLCs harbored previously reported driver gene alterations, all of which were shared between the two components. The median concordance rate of candidate somatic mutations between the two components was 71% (range, 60% 100%  LCNECs have a similar genomic profile to SCLC, including promising therapeutic targets, such as the PI3K/AKT/mTOR pathway and other gene alterations. Sequencing based molecular profiling is warranted in LCNEC for targeted therapies.
Relationship Between Thickness of Calcium on Optical Coherence Tomography and Crack Formation After Balloon Dilatation in Calcified Plaque Requiring Rotational Atherectomy.
Venue: Circulation journal official journal of the Japanese Circulation Society

Target lesion calcification is known to influence percutaneous coronary intervention. We evaluated the effects of rotational atherectomy (RA) and subsequent balloon angioplasty on calcified coronary lesions using optical coherence tomography (OCT) METHODSANDRESULTS Thirty seven calcified lesions in 36 patients were treated with RA followed by balloon angioplasty and stent implantation. In all patients, serial OCT images obtained after RA, after balloon angioplasty, and after stent implantation were analyzed at 1 mm intervals. The arc and thickness of the calcium component were measured after RA. The formation of calcium cracks was assessed after balloon angioplasty. A total of 625 segments were analyzed. The formation of calcium crack after balloon angioplasty was associated with greater stent cross sectional area (7.38+ 1.92 vs. 7.13+ 1.68 mm(2) P=0.035) as well as greater lumen gain (3.89+ 1.53 vs. 3.40+ 1.46 mm(2) P<0.001) Segments with calcium cracks after angioplasty had a larger median calcium arc (360deg, IQR, 246 360deg vs. 147deg, IQR, 118 199deg, P<0.001) and a thinner calcium thickness (0.53+ 0.28 vs. 1.02+ 0.42 mm, P<0.001) than those without. The optimal thresholds of calcium arc and calcium thickness for the prediction of cracks were 227deg and 0.67 mm, respectively.  Larger calcium arc and thinner calcium thickness were associated with formation of calcium crack. Presence of calcium crack was the important determinant of optimal stent expansion.
Low grade cribriform cystadenocarcinoma arising from a minor salivary gland: a case report.
Venue: Journal of oral science

Low grade cribriform cystadenocarcinoma (LGCCC) is a recently described rare tumor of the salivary gland; this tumor most frequently arises from the parotid gland. Here, we describe a case of LGCCC arising from a minor salivary gland in the buccal mucosa. A 72 year old man had a small mass on the left buccal mucosa. The mass was completely resected, and the postoperative course was uneventful. Histopathologically, the tumor comprised a single cyst with intraductal proliferation. Based on these histopathological findings along with immunohistochemistry a diagnosis of LGCCC arising from a minor salivary gland was made. ( 2016)
Clinical Impact of the Cardio Ankle Vascular Index for Predicting Cardiovascular Events After Acute Coronary Syndrome.
Venue: Circulation journal official journal of the Japanese Circulation Society

We hypothesized the cardio ankle vascular stiffness index (CAVI) could predict future cardiovascular events.  We enrolled 288 consecutive patients with acute coronary syndrome (ACS) who underwent CAVI measurement soon after the onset of ACS. Exclusion criteria were as follows: unable to detect significant stenosis by coronary angiography, severe aortic insufficiency, peripheral artery disease, atrial fibrillation (AF) informed consent was not given. We divided the patients into 2 groups according to the cutoff value of CAVI determined by receiver operating characteristics curve for the prediction of cardiovascular events: low CAVI group, 135 patients with CAVI =8.325; high CAVI group, 153 patients with CAVI >8.325. Patients were followed up for a median period of 15 months. The primary and secondary endpoints were the incidence of cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal ischemic stroke) and nonfatal ischemic stroke. Of the 288 patients, cardiovascular events occurred in 19 patients (6.6% The Kaplan Meier estimate of the event free rate revealed cardiovascular events occurred more frequently in the high CAVI group than in the low CAVI group (log rank, P<0.001) Multiple adjusted Cox proportional hazards analysis, including age, indicated the high CAVI group was an independent predictor of cardiovascular events (hazard ratio [HR] 18.00, P=0.005) and nonfatal ischemic stroke (HR 9.371, P=0.034) CONCLUSIONS High CAVI is an independent predictor of cardiovascular events and nonfatal ischemic stroke in patients with ACS.
Removal of excess polymer from a suspension containing hybrids of thermoresponsive polymer and carbon nanotubes using aggregation phenomenon

Hybrids of organic molecules and single walled carbon nanotubes (SWNTs) are attractive candidates for nanobiodevices. The removal of organic molecules after dispersing the SWNTs in organic media is a significant step in the preparation of these hybrid suspensions. We investigated the aggregation phenomenon in hybrids of poly(N isopropylacrylamide) (PNIPAAm) and SWNTs. Our results indicate that the hybrids efficiently precipitated when a buffer or salt solution was added to the suspension at 25 degrees C. 4mM tris(hydroxymethyl) aminomethane hydrochloride (Tris HCl) buffer was sufficient to precipitate the hybrids. Then, by repeated centrifugations and replacements of solvents, excess PNIPAAm molecules were efficiently removed from the suspension. Results of UV vis spectroscopy and atomic force microscopy (AFM) suggest that the PNIPAAm SWNT hybrids retained their hybridized structures even after the treatment process. However, the aggregation phenomenon was not observed at 4 degrees C. (C) 2016 The Japan Society of Applied Physics
Extracting relevance and affect information from physiological text annotation
Venue: User Modeling and User Adapted Interaction

We present physiological text annotation, which refers to the practice of associating physiological responses to text content in order to infer characteristics of the user information needs and affective responses. Text annotation is a laborious task, and implicit feedback has been studied as a way to collect annotations without requiring any explicit action from the user. Previous work has explored behavioral signals, such as clicks or dwell time to automatically infer annotations, and physiological signals have mostly been explored for image or video content. We report on two experiments in which physiological text annotation is studied first to (1) indicate perceived relevance and then to (2) indicate affective responses of the users. The first experiment tackles the user's perception of relevance of an information item, which is fundamental towards revealing the user's information needs. The second experiment is then aimed at revealing the user's affective responses towards a relevant text document. Results show that physiological user signals are associated with relevance and affect. In particular, electrodermal activity was found to be different when users read relevant content than when they read irrelevant content and was found to be lower when reading texts with negative emotional content than when reading texts with neutral content. Together, the experiments show that physiological text annotation can provide valuable implicit inputs for personalized systems. We discuss how our findings help design personalized systems that can annotate digital content using human physiology without the need for any explicit user interaction.
RING POROSITY AND EARLYWOOD VESSELS: A REVIEW ON EXTRACTING ENVIRONMENTAL INFORMATION THROUGH TIME

Many anatomical features in trees result from their reaction to fluctuating environmental conditions, and some can be measured and dated. Recently, quantitative wood anatomy has been used to build time series, and consequently to study the responses of trees through time. This involves the application of dendrochronological techniques, although some methodological adaptations are necessary when using anatomical variables. Until now, the study of continuous anatomical series has proven to be very promising when applied to the earlywood vessels of ring porous trees, due to their great physiological relevance.In this paper, we review the main aspects that must be considered when building continuous series of earlywood vessel features of ring porous trees as compared to 'classical' dendrochronology. We first discuss the procedures for building individual series and chronologies, starting with the selection of variables, examining their statistical properties, and assessing how crossdating and detrending should be adapted. We also show that time series of earlywood vessels usually exhibit a low common signal, but in contrast are strongly related to climate, and often reveal responses not recorded by the classical dendrochronological variables.In addition, we deal with the optimization of environmental signals, by first evaluating multiple potential variables to be used, and indicate how to reduce their number according to the relations among them. As earlywood variables are basically determined by vessel number or vessel size, we discuss the search for the most appropriate variable to characterize vessel number, as well as the advantage of progressively selecting earlywood vessels attending to their size and position.Finally, we extend the application of these methodologies to diffuse porous species as compared to ring porous trees, and show that the climatic signal contained in their anatomical features is also relevant, provided that vessels are carefully selected upon their location within the ring.
Mining Aspect Specific Opinion using a Holistic Lifelong Topic Model
Venue: WWW

Aspect level sentiment analysis or opinion mining consists of several core sub tasks: aspect extraction, opinion identification, polarity classification, and separation of general and aspect specific opinions. Various topic models have been proposed by researchers to address some of these sub tasks. However, there is little work on modeling all of them together. In this paper, we first propose a holistic fine grained topic model, called the JAST (Joint Aspect based Sentiment Topic) model, that can simultaneously model all of above problems under a unified framework. To further improve it, we incorporate the idea of lifelong machine learning and propose a more advanced model, called the LAST (Lifelong Aspect based Sentiment Topic) model. LAST automatically mines the prior knowledge of aspect, opinion, and their correspondence from other products or domains. Such knowledge is automatically extracted and incorporated into the proposed LAST model without any human involvement. Our experiments using reviews of a large number of product domains show major improvements of the proposed models over state of the art baselines.
Design of a Voice Based Intelligent Prototype Model for Automatic Control of Multiple Home Appliances

The revolution in Information Technology(IT) and Artificial Intelligent has provided innovations in diverse kinds of home automation where appliances can be controlled effortlessly and seamlessly .In this paper a review of several home automation technologies was presented and the advantages voice based technology was considered trending among other technologies in terms of flexibility and cost and comfort. In this paper, the conceptual prototype design model and the circuit diagram for controlling multiple home appliances at the same time were presented. The model uses Arduino Uno microcontroller system to control multiple home electrical or electronic appliances with maximum of 5 volts. The design transmits voice command through user wireless microphone (attached to the user cloth) to the intelligence micro controller via graphical user interphase (GUI) The control software developed for the prototype model was implemented using C# programming language, Microsoft Visual Studio.Net and Microsoft Speech recognition system.
Design and Implementation of GSM Based Automation of Household Appliances

In this paper, GSM Based Automation of Electrical Household Appliances is presented. The problem of paying huge electricity bills generated by various household Electrical Electronic appliances at home/office is alarming. To help reduce the total number of energy use and amount to be spent on electricity bills, GSM Based Automation of Electrical Household Appliances is proposed. The system is designed to allow the user to control the switching ON/OFF of his/her electrical home appliances via mobile phone anywhere at any time. The system consists of hardware and software .Any household appliances can be switched ON by sending an SMS with the keyword 'LL1 or LL2 or LL3 .etc. from the user's mobile phone to the receiver panel at home, the receiver antenna picks the signal and forward it to microcontroller which decodes the keywords and command the instructions to trigger any device connected to the system ports. When the device (s) is/are switched ON, the system sends a feedback message back to the user stating the status of the device(s) Also user can switch OFF any of the appliances by sending an SMS with the keyword 'LL0' and the instruction would be carried out and message returned back to the sender.The system is implemented program written and tested with accurate results.
A generalized power iteration method for solving quadratic problem on the Stiefel manifold
Venue: Science China Information Sciences

In this paper, we first propose a novel generalized power iteration (GPI) method to solve the quadratic problem on the Stiefel manifold (QPSM) as $min_{W^{T}W=I}$minWTW=I Tr(WTAW 2WTB) along with the theoretical analysis. Accordingly, its special case known as the orthogonal least square regression (OLSR) is under further investigation. Based on the aforementioned studies, we then majorly focus on solving the unbalanced orthogonal procrustes problem (UOPP) As a result, not only a general convergent algorithm is derived theoretically but the efficiency of the proposed approach is verified empirically as well.
Numerical Solutions of a Generalized Nth Order Boundary Value Problems Using Power Series Approximation Method

In this paper, a new approach called Power Series Approximation Method (PSAM) is developed for the numerical solution of a generalized linear and non linear higher order Boundary Value Problems (BVPs) The proposed method is efficient and effective on the experimentation on some selected thirteen order, twelve order and ten order boundary value problems as compared with the analytic solutions and other existing methods such as the Homotopy Perturbation Method (HPM) and Variational Iteration Method (VIM) available in the literature. A convergence analysis of PSAM is also provided.
Disruptive Innovation: The Rise of Distance Education.
Venue: Clinical nurse specialist CNS

In the previous column, 1 I introduced the term disruptive innovation. Disruptive innovation (DI) can be defined as an innovation that provides a simpler, more convenient, more accessible, and more affordable alternative to traditional markets and/or products. The purpose of the innovation is not to purposefully wreak havoc but to provide value to those who currently may be unable to access or use the existing product. By providing value to the underserved, the consumer demand for the new product or idea frequently transforms the industry and eventually creates a new status quo. There are many examples of DI in healthcare and education, including the introduction of advanced practice nurses to meet patients' unmet needs. Nursing education will obviously be impacted by changes in the healthcare sector. See the previous column for more details about the impact of DI in higher education. Nurse educators could role model the characteristics of DI to include looking at the opportunities to be responsive toour consumers' (ie, students) needs and having the right attitude to effect change. The DI theory posits that disruptors not only create new markets to meet unmet needs but through continuing improvements, they also reshape current ones. For nurse educators, that means embracing new pedagogies and technologies to improve the quality and delivery of education, and specifically those strategies shown to work well for distance education. The fact that the Internet, hailed as the most disruptive influence of our time, has changedour ability to access information, and that this increased accessibility is available with mobile devices, begs our rethinking of traditional ways of teaching and learning in higher education. Faculty need to [seek] out new instructional and evidence based methods to offer our students the best education possible. Online learning is not a fad; it is not going awayVtherefore, nursing faculty should get on the online learning train, instead of running alongside or behind it. It is time for nurse faculty to influence and reshape the education market.
Efficient Ray Tracing Through Aspheric Lenses and Imperfect Bokeh Synthesis
Venue: Comput. Graph. Forum

We present an efficient ray tracing technique to render bokeh effects produced by parametric aspheric lenses. Contrary to conventional spherical lenses, aspheric lenses do generally not permit a simple closed form solution of ray surface intersections. We propose a numerical root finding approach, which uses tight proxy surfaces to ensure a good initialization and convergence behavior. Additionally, we simulate mechanical imperfections resulting from the lens fabrication via a texture based approach. Fractional Fourier transform and spectral dispersion add additional realism to the synthesized bokeh effect. Our approach is well suited for execution on graphics processing units (GPUs) and we demonstrate complex defocus blur and lens flare effects.
Performances et limites d'un procede a lit fluidise associant biofilm et liqueur mixte (IFAS) pour le traitement du carbone et de l'azote des eaux residuaires urbaines

Le procede hybride, a lit fluidise place dans un reacteur de type boues activees (IFAS) est une technologie de traitement du carbone et de l'azote tres attractive pour les collectivites en raison de sa compacite et facilement adaptable pour la rehabilitation des stations d'epuration a boue activee (BA) L'objectif de ce travail est de determiner les criteres de dimensionnement du procede IFAS en configuration trois bassins (anoxie/aerobie BA/aerobie IFAS) et d'apporter des recommandations sur les conditions de fonctionnement charges massiques appliquees, oxygene dissous, sequencage de l'aeration, configuration souhaitable. Pour cela, un pilote de 2,8 m 3 alimente en eau usee domestique a ete concu, instrumente et etudie pendant 2,5 ans. Differentes charges massiques ont ete appliquees et ont permis d'evaluer le dimensionnement possible du procede. La configuration IFAS trois reacteurs doit etre dimensionnee sur la base d'une charge massique appliquee de 0,25 a 0,30 kgDBO 5 /kgMVS LM /j sur le bassin biologique, associee a une concentration en MES de 2,3 g/L. Les ages de boues correspondant a ces charges varient de 4 a 5 jours dans la liqueur mixte (LM) La concentration en ammonium au rejet atteint 7 mgN/L avec un rendement de 85% a 16 degC. Le sequencage de l'aeration dans le reacteur aerobie place avant le reacteur IFAS (aerobie 1) est envisageable sans penaliser les rendements de traitement. Ce sequencage permet, pendant les periodes non aerees, d'augmenter le volume en conditions anoxique et augmente ainsi le flux denitrifie dans le reacteur biologique +23% Des propositions d'amelioration du transfert de l'oxygene en reacteur IFAS sont egalement presentees.
Elements traces metalliques Contaminants des eaux du fleuve Chari a N'Djamena

Un des principaux problemes que connaissent les eaux de surface est le deversement non controle des eaux usees des etablissements dont il est difficile de quantifier. Le Chari recoit des rejets d'eau usee domestique, hospitaliere et industrielle sans traitement prealable depuis la frontiere du Tchad avec la Republique Centrafricaine jusqu'au Lac Tchad. La presence des metaux traces dans le Chari resulte de processus naturel mais aussi des activites humaines. Les populations riveraines utilisent quotidiennement les eaux du Chari a plusieurs fins. Mots cles Metaux traces, Fleuve Chari, N'Djamena, parametres physicochimiques.  A key problem that encounters the water surface is caused by the uncontrolled discharge of waste water establishments it is difficult to quantifier. The Chari rever receives domestic wastewater discharges, industrial and hospital without treatment from the border Chad with the Central African Republic to Lake Chad. The presence of trace metals in the Chari result of natural processes but also by human activities. The local people use daily water Chari many purposes.  Trace metals, Chari River, N'Djamena, physicochemical parameters.
Nuevas cadenas de transporte de mercancias generadas por las infraestructuras logisticas de intercambio modal

Las nuevas pautas de transporte y de comercio en un mundo globalizado han modificado los requerimientos logisticos y los actores del escenario del transporte. Las cadenas logisticas y los servicios puerta a puerta se han sofisticado de manera que para poder prestar un servicio eficiente ha sido necesario desarrollar nodos de intercambio modal flexibles, ubicados estrategicamente, con altos niveles de calidad de servicio y accesos a las principales vias de alta capacidad del entorno. Dichos nodos de intercambio favorecen la implantacion de cadenas intermodales en las que cada modo de transporte se emplea en su tramo mas eficiente. En este articulo se pretende desarrollar conceptualmente la relacion entre el transporte y la logistica, asi como describir y enumerar las nuevas tipologias de plataformas logisticas. Existe una decidida apuesta porque Espana tenga la consideracion de plataforma logistica del sur de Europa, atrayendo el trafico de mercancias que llega a Europa, dirigiendolo por esta zona para su distribucion por el continente, se analiza en el articulo en que situacion se encuentra este hito dentro de la politica de planificacion de Espana.