nils-herrmann/clean_scirepeval huggingface dataset:
Pilot to Profit: Navigating Modern Business Entrepreneurship to Build Your Own Business Using Online Marketing, Social Media, Content Marketing and Sales

Lisa Larter Pilot to Profit: Navigating Modern Business Entrepreneurship to Build Your Own Business Using Online Marketing, Social Media, Content Marketing and Sales Morgan James Publishing (2016) $17.95 (paperback) 185 pagesPilot to profit: navigating modern Business Entrepreneurship to Build Your Own Business Using Online Marketing, Social Media, Content Marketing and Sales, is an instructive paperback that communicates the steps for new entrepreneurs from thought conception to opening the doors. The author, Lisa Larter, is a successful entrepreneur turned business coach who consults with businesses around the world through her web based training, Pilot to Profit. More details regarding her program, and the foundation of this book, can be found at http: lisalarter.com/programs.Over the course of 12 chapters, the author shares her insights from personal experience and trials. The firm basis of the book is that success in entrepreneurial endeavors begins with the entrepreneur's internal assessment. The first four chapters make up the first section regarding the author's "Profit Principles" which leads the reader to first sell themselves on the success of the idea (Chapter 1) gaining the right mindset and perspective of money (Chapter 2) properly defining the business model (Chapter 3) and knowing what really matters so you can measure success (Chapter 4) The second section, "Content Principles" made up of Chapters 5 and 6, focuses on the content of the business message. This is followed by a three chapter section, "Social Principles" where the author leads readers through foundational principles needed for a sound social media presence. In Chapter 10, which makes up the fourth section, the author reiterates the importance of the entrepreneur being involved and engaged in the selling process of the business. The book concludes with a discussion of the author's Pilot Project (Chapter 11) and resources from the author to assist readers to learn more (Chapter 12).The book shares some important insights for the beginning entrepreneur or the "would be" entrepreneur. Anyone who considers starting a business can certainly benefit from reading Pilot to Profit. However, the book is most appropriate for women owned businesses or women thinking about starting a company. The first section of the book is encouraging, engaging and instructional on overcoming self doubt and worry. The discussion on developing the right mindset about money and ways to overcome fears of owning a business set the foundations of success. The author shares her personal experiences of fear, failure, and success which provide a great level of credibility with the reader.The strength of the book is solidified in the author's sharing of principles for successful marketing of the business using social media. The author provides best practices for selecting the right content used in the marketing message, stating that "
The Impact of Social Media Content Marketing (SMCM) towards Brand Health

The emergence of Web 2.0 has created the new phenomenon in business strategies as it allowed two way communications between companies and the consumers. Nowadays, the business practitioners tend to use the social media marketing to create awareness and promote their brands to the customers. Nevertheless, the main point in sharing the information through the social media is about the content itself to attract more consumers engage with the brands. Social media content marketing (SMCM) also plays an important role in conveying effective information to the consumers thus attract them to keep engaging with the brands. Meanwhile, brand health is the evaluation from digital audiences about the brands and products. It measures the awareness of the brand for long term period thus develop the brand equity. There are few indicators in measuring the brand health such as time on site, repeat visitors, social likes, subscriptions, and bounce rates. There are still limited studies on the impact of social media content marketing (SMCM) towards brand health. The purpose of this study is to investigate the role of SMCM in increasing the brand health score
A simple example for the teaching of demand theory: Aggregate demand estimation for onions in India

Managerial economics textbooks rarely include empirical examples of demand estimation of any commodity from real data, perhaps because in reality one must consider coupled demand systems. We suggest that on a national level and over a short time, the price volume data for onions provide a bona fide example of a single commodity demand curve. Since the onion has no real substitutes and taste for onions does not fluctuate, the demand curve does not shift over time. Empirical analysis of aggregated national level data yields a demand curve with two regimes: constant consumption at low prices, and constant budget at high prices.
The science, development, and commercialization of postharvest biocontrol products

Postharvest biological control agents as a viable alternative to the use of synthetic chemicals have been the focus of considerable research for the last 30 years by many scientists and several commercial companies worldwide. Several antagonists of postharvest pathogens have been identified and tested in laboratory, semi commercial, and commercial settings and were developed into commercial products. The discovery and development of these antagonists into a product followed a paradigm in which a single antagonist isolated from one commodity was also expected to be effective on other commodities that vary in their genetic background, physiology, postharvest handling, and susceptibility to pathogens. In most cases, product development was successfully achieved but their full commercial potential was not realized. The low success rate of postharvest biocontrol products has been attributed to several problems, including difficulties in mass production and formulation of the antagonist, the physiological status of the harvested commodity and its susceptibility to specific pathogens. All these factors played a major role in the reduced and inconsistent performance of the biocontrol product when used under commercial conditions. Although many studies have been conducted on the mode of action of postharvest microbial antagonists, our understanding is still very incomplete. In this regard, a systems approach, that takes into account all the components of the biocontrol system, may represent the best approach to investigating the network of interactions that exist. Very little is known about the overall diversity and composition of microbial communities on harvested produce and how these communities vary across produce types, their function, the factors that influence the composition of the microbiota after harvest and during storage, and the distribution of individual taxa. In light of the progress made in recent years in metagenomic technologies, this technology should be used to characterize the composition of microbial communities on fruit and vegetables. Information on the dynamics and diversity of microbiota may be useful to developing a new paradigm in postharvest biocontrol that is based on constructing synthetic microbial communities that provide superior control of pathogens.
Integrated management of postharvest gray mold on fruit crops

Gray mold, incited by Botrytis cinerea causes major postharvest losses in a wide range of crops. Some infections that occur in the field remain quiescent during the growing season and develop after harvest. The pathogen is also capable of infecting plant tissues through surface injuries inflicted during harvesting and subsequent handling; these develop during storage, even at 0 degC, and spread among products by aerial mycelial growth and conidia. The postharvest decay by this pathogen is controlled by a combination of preharvest and postharvest practices. To minimize postharvest gray mold, control programs rely mainly on applications of fungicides. However, mounting concerns of consumers and regulatory authorities about risks associated with chemical residues in food have led to imposition of strict regulations, the banning of use of certain chemical groups, and preferences by wholesaler, retailers and consumers to avoid chemically treated produce. These developments have driven the search for alternative management strategies that are effective and not reliant on conventional fungicide applications. In this review, conventional and alternative control strategies are discussed including their advantages and disadvantages. They include the use of conventional fungicides, biocontrol agents, physical treatments, natural antimicrobials, and disinfecting agents. Based on examples to control gray mold on specific crops, it is concluded that an integrated management program where adoption of a holistic approach is the key for meeting the challenge of minimizing postharvest losses caused by B. cinerea To optimize the efficacy of treatments, it is essential to understand their mechanism of action as much as possible. Information about direct and indirect effects of each approach on the pathogen is also presented.
Induced resistance to control postharvest decay of fruit and vegetables

More than one third of harvested fruit and vegetables are lost and do not reach the customers mainly due to postharvest decay. During the last decade, several postharvest fungicides have been excluded from the market, or their allowed residues have been significantly decreased. Therefore, there is growing interest in eco friendly and safe alternatives to synthetic fungicides. Induced resistance has gained increasing attention as a sustainable strategy to manage postharvest decay of fruit and vegetables. Their natural resistance can be increased by various means, such as biocontrol agents or their secreted elicitors. Alternatively, physical means, such as UV C, ozone, and heat treatment, can prime plant resistance through abiotic stress. Moreover, various defense related phytohormones, biological elicitors, non organic elicitors, and volatile organic compounds have been shown to induce plant resistance. During the last decades, new technologies have enabled the evaluation of gene expression, such as quantitative real time PCR and the most recent next generation sequencing, and thus the quantification of physiological changes, which have revealed new knowledge about preharvest and postharvest induced resistance in response to various treatments. These techniques allow optimization of postharvest application of the control means, although these data cannot disregard the evaluation of in vivo effectiveness. The elicitation of host defenses prevents the appearance of resistant isolates of pathogens. Induced resistance can lead to increased levels of phenolic compounds in the plant tissues, which often have antioxidant properties that are highly beneficial to humans. Moreover, induced resistance preserves the natural microflora, which is rich in potential biocontrol agents, and which provides a combined approach in the control of postharvest decay that is sustainable and safe for both growers and consumers. This approach meets the requirements of integrated disease management on sustainable use of pesticides that in the EU is implemented through Directive 128/2009. This review summarizes recent achievements and knowledge of the elicitation of host defenses to control postharvest decay of fruit and vegetables, and provides an outlook on the new challenges in this fascinating subject.
Biological control of postharvest diseases by microbial antagonists: how many mechanisms of action?
Venue: European Journal of Plant Pathology

The postharvest phase has been considered an environment for successful application of biological control agents (BCAs) However, the interactions between fungal pathogen, host (fruit) and antagonist are influenced by several parameters such as temperature, oxidative stresses, oxygen composition and water activity that could determine the success of biocontrol. Knowledge of the modes of action of BCAs is essential in order to enhance their viability and increase their potential in disease control. The antagonists display a wide range of modes of action: antibiosis, competition for nutrients and space, parasitism and induction of resistance are considered the main ones. Their efficacy, however, is related to the host and the pathogen; sometimes, these mechanisms could act simultaneously, and it is therefore difficult to establish which is related to a specific antifungal action. The current review presents a brief summary of the research that has led to a better understanding of the mode of action of BCAs with particular emphasis on the most recent literature.
Tone dependent error diffusion based on an updated blue noise model
Venue: J. Electronic Imaging

The conventional blue noise model that specifies the desired noise characteristics of an ideal halftone has been updated recently, and simulation results showed that the updated model can serve as a better guideline for developing halftone algorithms. At the moment, only a feature preserving multiscale error diffusion based algorithm was developed based on the updated noise model. As the algorithm does not support real time applications, a tone dependent error diffusion (TDED) algorithm is developed based on the updated noise model. To support the proposed TDED algorithm, we optimize a diffusion filter and a quantizer threshold for each possible input gray level based on the updated noise model, such that the algorithm can adapt its diffusion filter and quantizer according to the input intensity value of a pixel to produce a halftone. Simulation results showed that the proposed TDED algorithm can successfully produce halftones bearing the desired noise characteristics as specified by the updated noise model. As a consequence, it provides better performance than conventional error diffusion based algorithms in terms of various measures including radially averaged power spectrum density and anisotropy. When processing real images, it can eliminate directional artifacts, regular structure patterns, and unintended sharpening effects in its halftoning outputs.
A clinically applicable molecular classification for high grade serous ovarian cancer based on hormone receptor expression
Venue: Scientific reports

To establish an effective hormone receptor based molecular classification of high grade serous ovarian cancer (HGSC) we retrospectively examined 875 consecutive HGSC patients who underwent primary surgery at our hospital and constructed tissue microarrays from these specimens. The expression levels of the hormone receptors were as follows: ER 64.4% PR 12.6% AR 35.6% FSHR 54.5% LHR 34.8% and GnRHR 88.3% Based on clustering of their expression patterns, we classified patients into five subgroups with distinctive clinical features (PR+ PR ER AR+ PR ER AR PR ER AR+ and PR ER AR Patients in the PR group were younger compared to those in the other groups (p 0.001) More patients were of advanced stage in the PR ER AR group than the other groups (p 0.020) A greater proportion of patients were sensitive to platinum based chemotherapy in the PR ER AR group compared with the other groups (p 0.034) A trend of increasing risk of death was observed among these subgroups (p 0.001) In the multivariate analysis, patients also had orderly increased hazard ratios for death in the PR (HR 2.256, 95% CI, 0.983 5.175) PR ER AR (HR 2.188, 95% CI, 1.004 4.796) PR ER AR (HR 2.316, 95% CI, 1.097 5.082) and PR ER AR (HR 2.928, 95% CI, 1.366 6.276) subgroups compared to the PR ER AR+ subgroup. Our classification could help predict patient clinical outcomes, guide individual treatments and stratify patients in future clinical trials.
Molecular mode of action of NKP 1339 a clinically investigated ruthenium based drug involves ER and ROS related effects in colon carcinoma cell lines
Venue: Investigational New Drugs

Sodium trans [tetrachloridobis(1H indazole)ruthenate(III) (NKP 1339) is a clinically investigated ruthenium based metal complex, which shows promising results in solid tumors, such as non small cell lung cancer, colorectal carcinoma, and most distinctively in gastrointestinal neuroendocrine tumors. In previous studies, fast binding to albumin as well as transferrin could be shown. The enhanced permeability and retention (EPR) effect, which is diversely being exploited for tumor targeting, could therefore be applicable for NKP 1339. Here we studied the serum dependence of its biological activity in various methods, influencing its cellular accumulation, cytotoxicity as well as the generation of reactive oxygen species (ROS) ROS lead to Nrf2 activation, which is known to activate antioxidant response gene transcription. GRP78 down regulation on the protein level suggests ER associated protein degradation (ERAD) as a mode of action, as RNA levels are only mildly affected. Another important part for the mode of action is endoplasmic reticulum (ER) stress, as different factors are highly upregulated on the protein level. For example PERK, a transmembrane receptor which is released by GRP78 when the ER is disturbed, is upregulated and phosphorylated. EIF2a is phosphorylated, which leads to an inhibition of CAP dependent translation and other stress responses. The transcription factor CHOP (DDIT3) which promotes ER stress dependent apoptosis, is time and concentration dependently upregulated. Finally cytotoxicity tests could prove that inhibition of ER stress and ER stress mediated apoptosis leads to decreased cytotoxic effects of NKP 1339, which highlights the involvement of this mechanism in the mode of action.
139 Clinically Applicable and Biologically Validated MRI Radiomic Test Method Predicts Glioblastoma Genomic Landscape and Survival.
Venue: Neurosurgery

Imaging is the modality of choice for noninvasive characterization of biological tissue and organ systems; imaging serves as early diagnostic tool for most disease processes and is rapidly evolving, thus transforming the way we diagnose and follow patients over time. A vast number of cancer imaging characteristics have been correlated to underlying genomics; however, none have established causality. Therefore, our objectives were to test if there is a causal relationship between imaging and genomic information; and to develop a clinically relevant radiomic pipeline for glioblastoma molecular characterization.  Functional validation was performed using a prototypic in vivo RNA interference based orthotopic xenograft mouse model. The automated pipeline collects 4800 MRI derived texture features per tumor. Using univariate feature selection and boosted tree predictive modeling, a patient specific genomic probability map was derived and patient survival predicted (The Cancer Genome Atlas/MD Anderson data sets) RESULTS Data demonstrated a significant xenograft to human association (area under the curve [AUC] 84% P .001) Further, epidermal growth factor receptor amplification (AUC 86% P .0001) O methylguanine DNA methyltransferase methylation/expression (AUC 92% P .001) glioblastoma molecular subgroups (AUC 88% P .001) and survival in 2 independent data sets (AUC 90% P .001) was predicted.  Our results for the first time illustrate a causal relationship between imaging features and genomic tumor composition. We present a directly clinically applicable analytical imaging method termed Radiome Sequencing to allow for automated image analysis, prediction of key genomic events, and survival. This method is scalable and applicable to any type of medical imaging. Further, it allows for human mouse matched coclinical trials, in depth end point analysis, and upfront noninvasive high resolution radiomics based diagnostic, prognostic, and predictive biomarker development.
EFEKTIFITAS PENGGUNAAN VIRGIN COCONUT OIL (VCO) SECARA TOPIKAL UNTUK MENGATASI LUKA TEKAN (DEKUBITUS) GRADE I DAN II

EFEKTIFITAS PENGGUNAAN VIRGIN COCONUT OIL (VCO) SECARA TOPIKAL UNTUK MENGATASI LUKA TEKAN (DEKUBITUS) GRADE I DAN II Siti Fatonah 1) Ade Kartika Hrp 1) Ratna Dewi 1) 1) Jurusan Keperawatan Poltekkes Kemenkes Tanjungkarang  Effectiveness of the use of Virgin Coconut Oil (VCO) In Topical Wound To Overcome Press (decubitus) Grade I and II Pressure sores are localized to the tissue injury above the prominent bone due to continuous pressure in the long term. Pressure sores increased mortality and long day care in some countries. Virgin Coconut Oil (VCO) is a pure coconut oil obtained by the process without heating so that the content of both substances in it can be maintained. Quasi experimental research design that aims to determine the effectiveness of using Virgin Coconut Oil for healing of pressure sores grade I and II in patients with pressure sores. Data collection tool score bates jensen observation sheet as wound healing process measurement instruments. Study sample 42 respondents are divided into 21 groups of 21 respondents intervention and control groups. Statistical tests using independent t test with an alpha of 5% The results showed no significant difference to the score bates jensen decrease in VCO treated patients compared with normal coconut oil (pv 0.000) Multivariate analysis showed factors influencing albumin bates jensen difference scores in patients treated with VCO. Researchers suggested to use in the treatment of pressure sores VCO grade I and II in patients with pressure sores in RSUDAM Abdul Moeloek Lampung Province. Key words VCO, pressure ulcer Abstrak E fektifitas Penggunaan Virgin Coconut Oil (V CO s ecara Topikal u ntuk Mengatasi Luka Tekan (Dekubitus) Grade I Dan I I. Luka tekan adalah injury terlokalisir pada jaringan diatas tulang yang menonjol akibat tekanan terus menerus dalam jangka waktu yang lama. Luka tekan meningkatkan mortalitas dan lama hari perawatan dibeberapa negara. Virgin Coconut Oil (VCO) adalah minyak kelapa murni yang diperoleh dengan proses tanpa pemanasan sehingga kandungan zat zat baik didalamnya dapat dipertahankan. Desain Penelitian kuasi eksperimen yang bertujuan untuk mengetahui efektifitas penggunaan Virgin Coconut Oil terhadap penyembuhan luka tekan grade I dan II pada pasien yang mengalami luka tekan. Alat pengumpul data lembar observasi skor bates jensen sebagai instrumen pengukuran proses penyembuhan luka. Sampel penelitian 42 responden yang terbagi kedalam 21 kelompok intervensi dan 21 responden kelompok kontrol. Uji statistik menggunakan independen t test dengan alpha 5% Hasil penelitian menunjukkan ada perbedaan yang signifikan terhadap penurunan skor bates jensen pada pasien yang dirawat dengan VCO dibandingkan dengan minyak kelapa biasa (p v =0,000) Analisis multivariat menunjukkan faktor kadar albumin mempengaruhi selisih skor bates jensen pada pasien yang dirawat dengan VCO. Peneliti menyarankan untuk menggunakan VCO pada perawatan luka tekan grade I dan II pada pasien dengan luka tekan di RSUDAM Abdul Moeloek Propinsi Lampung.  VCO, luka tekan