nils-herrmann/clean_scirepeval huggingface dataset:
CD19 Targeted CAR T cells as novel cancer immunotherapy for relapsed or refractory B cell acute lymphoblastic leukemia.
Venue: Clinical advances in hematology oncology H&O

Immunotherapy has demonstrated significant potential for the treatment of patients with chemotherapy resistant hematologic malignancies and solid tumors. One type of immunotherapy involves the adoptive transfer of T cells that have been genetically modified with a chimeric antigen receptor (CAR) to target a tumor. These hybrid proteins are composed of the antigen binding domains of an antibody fused to T cell receptor signaling machinery. CAR T cells that target CD19 recently have made the jump from the laboratory to the clinic, and the results have been remarkable. CD19 targeted CAR T cells have induced complete remissions of disease in up to 90% of patients with relapsed or refractory B cell acute lymphoblastic leukemia (B ALL) who have an expected complete response rate of 30% in response to chemotherapy. The high efficacy of CAR T cells in B ALL suggests that regulatory approval of this therapy for this routinely fatal leukemia is on the horizon. We review the preclinical development of CAR T cells and their early clinical application for lymphoma. We also provide a comprehensive analysis of the use of CAR T cells in patients with B ALL. In addition, we discuss the unique toxicities associated with this therapy and the management schemes that have been developed.
CAR T Cell Therapy in Acute Lymphoblastic Leukemia and Potential for Chronic Lymphocytic Leukemia
Venue: Current Treatment Options in Oncology

transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) represents a powerful targeted immunotherapy that has shown great promise in some of the most refractory leukemias. CAR modified T cells directed against CD19 have led the way, setting a high standard with remission rates as high as 90 in clinical trials for relapsed/refractory acute lymphoblastic leukemia (ALL) Yet, the first demonstration of efficacy was in another disease, chronic lymphocytic leukemia (CLL) in which CD19 targeted CAR T cells eradicated bulky, highly refractory disease. Despite early encouraging results, clinical trials in CLL have yielded lower response rates, revealing disease specific differences in response in this form of immunotherapy. Ongoing research focused on identifying and overcoming these limitations, promises to improve response rates. Beyond the induction of remission, the transformative impact of engineered T cell therapy lies in its potential for long term disease control. With longer follow up and durable T cell persistence now reported, we are closer to answering the question of whether sustained remissions are possible with CAR T cell monotherapy. As might be expected with a highly effective therapy using a single mechanism of action, escape pathways have emerged. Combinatorial approaches are needed to anticipate and prevent this mode of relapse. Lastly, toxicity management is vital to ensure the safety of this exciting cancer immunotherapy.
Analisis Beban Kerja Tenaga Rekam Medis dengan Metode Workload Indicators of Staffing Need (WISN) di Rumah Sakit Islam Ibnu Sina Kota Padang Tahun 2016

FAKULTAS KESEHATAN MASYARAKAT UNIVERSITAS ANDALAS Skripsi, Juni 2016 NINDY AUDIA NADIRA No. BP 1210332021 ANALISIS BEBAN KERJA TENAGA REKAM MEDIS DENGAN METODE WORKLOAD INDICATORS OF STAFFING NEED (WISN) DI RUMAH SAKIT ISLAM IBNU SINA KOTA PADANG TAHUN 2016 xiv 102 halaman, 18 tabel, 3 gambar, 14 lampiran ABSTRAK Tujuan Beban kerja tenaga rekam medis di Rumah Sakit Islam Ibnu Sina Kota Padang tinggi dikarenakan jumlah kunjungan pasien mengalami peningkatan sebanyak 83.733 kunjungan pada tahun 2015 dibandingkan dengan tahun 2014. Tujuan penelitian ini adalah untuk mengetahui beban kerja dan jumlah kebutuhan tenaga rekam medis di Rumah Sakit Islam Ibnu Sina Kota Padang tahun 2016. Metode Penelitian ini menggunakan metode penelitian campuran (mixed method research) dengan model penelitian Concurrent Embedded Strategy. Teknik pemilihan informan yang digunakan adalah purposive sampling. Pengumpulan data dilakukan dengan cara observasi, wawancara mendalam, dan telaah dokumen. Data diolah dengan rumus perhitungan Workload Indicators of Staffing Need (WISN) dan mereduksi data ke dalam matrik hasil wawancara mendalam. Penelitian ini dilakukan di unit rekam medis Rumah Sakit Islam Ibnu Sina Kota Padang. Hasil Hasil penelitian ini adalah jumlah tenaga rekam medis di Rumah Sakit Islam Ibnu Sina Kota Padang sebanyak 24 orang dengan latar belakang pendidikan DIII Rekam Medis dan SLTA/sederajat, waktu kerja tersedia dalam setahun adalah 116.760 menit/tahun, standar beban kerja tertinggi adalah penyusunan laporan berkala, dengan standar kelonggaran 0,16, jumlah tenaga yang dibutuhkan berdasarkan perhitungan WISN adalah 36 orang dengan rasio WISN sebesar 0,67, dan beban kerja tertinggi adalah kegiatan pelayanan rekam medis. Kesimpulan Menurut perhitungan WISN, dibutuhkan jumlah tenaga rekam medis sebesar 36 orang. Hal ini menunjukkan bahwa terdapat kebutuhan tenaga rekam medis yang belum terpenuhi sebanyak 12 orang. Oleh karena itu disarankan kepada pihak rumah sakit bagian perencanaan SDM untuk mempertimbangkan penambahan tenaga dan mengoptimalkan kinerja tenaga di unit rekam medis sehingga tercapai beban kerja tenaga rekam medis yang ideal. Daftar Pustaka 35 (2003 2016) Kata Kunci Beban Kerja, WISN, Rekam Medis
ANALISIS KEBUTUHAN PETUGAS REKAM MEDIS BERDASARKAN BEBAN KERJA DI INSTALASI REKAM MEDIS RS AISYIAH MUNTILAN

Latar Belakang: Berdasarkan hasil observasi, RS Aisyiah Muntilan memiliki 7 orang petugas rekam medis yang terdiri dari 4 orang petugas pendaftaran dan 3 orang petugas pengolahan data dan pelaporan. Petugas pendaftaran terbagi dalam 3 shift yaitu: pagi, siang, malam, dan hari libur. Dengan adanya poliklinik saat shift pagi, petugas pendaftaran yang hanya 1 orang merasa keteteran dalam melayani pasien. Untuk membantu petugas pendaftaran, biasanya petugas pengolahan data dan pelaporan diturunkan sehingga akan mempengaruhi beban kerja petugas pengolahan data dan pelaporan. Oleh karena itu, peneliti ingin mengetahui bagaimana beban kerja dan kebutuhan petugas rekam medis di RS Aisyiah Muntilan untuk mengetahui kebutuhan petugas secara keseluruhan dengan menggunakan metode WISN (Workload Indicator Staff Need) berdasarkan analisis problem solving yang dilakukan.  Mengidentifikasi jumlah petugas rekam medis yang tersedia, mengidentifikasi uraian tugas petugas rekam medis, mengidentifikasi hambatan yang ada di Instalasi Rekam Medis dan solusinya, menghitung standar waktu kegiatan di Instalasi Rekam Medis, menghitung kebutuhan tenaga berdasarkan beban kerja di Instalasi Rekam Medis Metode: Jenis penelitian adalah deskriptif dengan pendekatan kuantitatif dan rancangan penelitian crossectional. Sampel penelitian adalah petugas rekam medis di RS Aisyiah Muntilan dengan sampel terbatas. Hasil: Setelah dilakukan perhitungan kebutuhan petugas dengan rumus WISN ternyata tidak diperlukan penambahan petugas. Hal ini menunjukan bahwa beban kerja yang tinggi bukan karena kurangnya petugas namun karena sistem yang ada di pendaftaran dan poliklinik yang kurang baik.  Penambahan petugas tidak diperlukan namun perlu perbaikan sistem yang ada.
Effects of Liver Transplantation on Lipids and Cardiovascular Disease in Children With Homozygous Familial Hypercholesterolemia.
Venue: The American journal of cardiology

Homozygous familial hypercholesterolemia (HoFH) is a rare, inherited, life threatening, metabolic disorder of low density lipoprotein (LDL) receptor function characterized by elevated serum LDL cholesterol (LDL C) and rapidly progressive atherosclerotic cardiovascular disease (ACVD) Since LDL receptors are predominantly found on hepatocytes, orthotopic liver transplantation (OLT) has emerged as a viable intervention for HoFH because LDL receptor activity is restored. This study assessed the effects of OLT on ACVD and ACVD risk factors in pediatric patients with HoFH. We analyzed lipids, lipoproteins, body mass index, glucose, blood pressure, and cardiovascular imaging in 8 pediatric patients who underwent OLT for HoFH. Total serum cholesterol, LDL C, lipoprotein (a) and apolipoprotein B/apolipoprotein A1 ratio decreased to normal values in all subjects (p values <0.001) at 1 month after OLT and were maintained for the length of follow up (2 to 6 years) There were few complications related to surgery or immunosuppressive therapy. Two patients developed mild hypertension. In the first 4 subjects monitored for 4 to 6 years after OLT, coronary artery disease did not develop or progress except in 1 minor artery in 1 subject and actually regressed in 2 subjects with >50% stenosis. However, aortic valve stenosis progressed in 2 of 4 subjects. In conclusion, OLT is an effective therapeutic option for patients with HoFH with coronary artery disease and persistently elevated serum LDL C despite maximum medical therapy. Aortic valvular disease may progress. Long term data are needed to evaluate the true risk benefit ratio of this surgical approach.
Trend analysis of performance parameters of pre packed columns for protein chromatography over a time span of ten years.
Venue: Journal of chromatography. A

Pre packed small scale chromatography columns are increasingly used for process development, for determination of design space in bioprocess development, and for post licence process verifications. The packing quality of 30,000 pre packed columns delivered to customers over a period 10 years has been analyzed by advanced statistical tools. First, the data were extracted and checked for inconsistencies, and then were tabulated and made ready for statistical processing using the programming language Perl (https:/www.perl.org/ and the statistical computing environment R (https:/www.r project.org/ Reduced HETP and asymmetry were plotted over time to obtain a trend of packing quality over 10 years. The obtained data were used as a visualized coefficient of variation analysis (VCVA) a process that has often been applied in other industries such as semiconductor manufacturing. A typical fluctuation of reduced HETP was seen. A Tsunami effect in manufacturing, the effect of propagation of manufacturing deviations leading to out of specification products, was not observed with these pre packed columns. Principal component analysis (PCA) showed that all packing materials cluster. Our data analysis showed that the current commercially available chromatography media used for biopharmaceutical manufacturing can be reproducibly and uniformly packed in polymer based chromatography columns, which are designed for ready to use purposes. Although the number of packed columns has quadrupled over one decade the packing quality has remained stable.
Utilization of interfacial engineering to improve physicochemical stability of b carotene emulsions: Multilayer coatings formed using protein and protein polyphenol conjugates.
Venue: Food chemistry

The impact of lactoferrin (LF) chlorogenic acid (CA) and Epigallocatechin 3 gallate (EGCG) conjugates on the physicochemical properties of b carotene emulsions was investigated. Formation of lactoferrin polyphenol conjugates, which was confirmed by SDS PAGE, caused changes in the structure and nature of lactoferrin. Based on layer by layer electrostatic deposition, b carotene bilayer emulsions were prepared by lactoferrin and lactoferrin polyphenol conjugates at pH 7.0. The physicochemical properties of primary and secondary emulsions were evaluated and the results suggested that LF polyphenol conjugates stabilized primary and secondary emulsions exhibited better emulsifying properties and improved physical stability of b carotene bilayer emulsions under freeze thaw, ionic strength and thermal treatments. In addition, the lactoferrin polyphenol conjugates could effectively enhance chemical stability of b carotene in oil in water emulsions against heat treatment and ultraviolet light exposure, and the least degradation of b carotene occurred in LF EGCG conjugate stabilized primary emulsion. The interfacial engineering technology utilized in this study may lead to the formation of emulsions with improved physicochemical and functional performance.
WATER CONSERVATION: OBSERVATIONS FROM A HIGHER EDUCATION FACILITY MANAGEMENT PERSPECTIVE

Sustainable or green building practices have been adopted by most higher education institutions for their new campus buildings, major renovations and daily operations. This paper provides a synthesis of opinions and existing practices related to water conservation in institutional green buildings of member institutions of APPA (formerly the Association of Physical Plant Administrators) A specific focus regarding waterless urinals and their operation was attempted. A web based survey and follow up one to one interviews were utilized to extract information and data from these industry professionals. The survey evaluated the institution's use of policy related to sustainable building practices and focused on their approaches to water conservation. Regional preferences are provided and barriers to some water conservation practices and approaches have been identified. Operational challenges are evident, particularly as they relate to waterless urinals. It is clear that higher education institutions a.
Ectopic and Visceral Fat Deposition in Lean and Obese Patients With Type 2 Diabetes
Venue: Journal of the American College of Cardiology

Type 2 diabetes (T2D) and obesity are associated with nonalcoholic fatty liver disease, cardiomyopathy, and cardiovascular mortality. Both show stronger links between ectopic and visceral fat deposition, and an increased cardiometabolic risk compared with subcutaneous fat.  This study investigated whether lean patients (Ln) with T2D exhibit increased ectopic and visceral fat deposition and whether these are linked to cardiac and hepatic changes.  Twenty seven obese patients (Ob) with T2D, 15 Ln T2D, and 12 normal weight control subjects were studied. Subjects underwent cardiac computed tomography, cardiac magnetic resonance imaging (MRI) proton and phosphorus MR spectroscopy, and multiparametric liver MR, including hepatic proton MRS, T1 and T2* mapping yielding "iron corrected T1" [cT1] Results Diabetes, with or without obesity, was associated with increased myocardial triglyceride content (p 0.01) increased hepatic triglyceride content (p 0.04) and impaired myocardial energetics (p 0.04) Although cardiac structural changes, steatosis, and energetics were similar between the T2D groups, epicardial fat (p 0.04) hepatic triglyceride (p 0.01) and insulin resistance (p 0.03) were higher in Ob T2D. Epicardial fat, hepatic triglyceride, and insulin resistance correlated negatively with systolic strain and diastolic strain rates, which were only significantly impaired in Ob T2D (p 0.001 and p 0.006, respectively) Fibroinflammatory liver disease (elevated cT1) was only evident in Ob T2D patients. cT1 correlated with hepatic and epicardial fat (p 0.001 and p 0.01, respectively) Conclusions Irrespective of body mass index, diabetes is related to significant abnormalities in cardiac structure, energetics, and cardiac and hepatic steatosis. Obese patients with T2D show a greater propensity for ectopic and visceral fat deposition.
Effective dynamics of the nonlinear Schrodinger equation on large domains

We consider the nonlinear Schr\"odinger (NLS) equation posed on the box [0,L]^d$ with periodic boundary conditions. The aim is to describe the long time dynamics by deriving effective equations for it when $L$ is large and the characteristic size \epsilon$ of the data is small. Such questions arise naturally when studying dispersive equations that are posed on large domains (like water waves in the ocean) and also in theory of statistical physics of dispersive waves, that goes by the name of "wave turbulence" Our main result is deriving a new equation, the continuous resonant (CR) equation, that describes the effective dynamics for large $L$ and small \epsilon$ over very large time scales. Such time scales are well beyond the (a) nonlinear time scale of the equation, and (b) the Euclidean time scale at which the effective dynamics are given by (NLS) on \mathbb R^d$ The proof relies heavily on tools from analytic number theory, such as a relatively modern version of the Hardy Littlewood circle method, which are modified and extended to be applicable in a PDE setting.
Comparison of Dynamic Characteristics Between Virtual Synchronous Generator and Droop Control in Inverter Based Distributed Generators
Venue: IEEE Transactions on Power Electronics

In recent researches on inverter based distributed generators, disadvantages of traditional grid connected current control, such as no grid forming ability and lack of inertia, have been pointed out. As a result, novel control methods like droop control and virtual synchronous generator (VSG) have been proposed. In both methods, droop characteristics are used to control active and reactive power, and the only difference between them is that VSG has virtual inertia with the emulation of swing equation, whereas droop control has no inertia. In this paper, dynamic characteristics of both control methods are studied, in both stand alone mode and synchronous generator connected mode, to understand the differences caused by swing equation. Small signal models are built to compare transient responses of frequency during a small loading transition, and state space models are built to analyze oscillation of output active power. Effects of delays in both controls are also studied, and an inertial droop control method is proposed based on the comparison. The results are verified by simulations and experiments. It is suggested that VSG control and proposed inertial droop control inherits the advantages of droop control, and in addition, provides inertia support for the system.
Business Complexity and Risk Management: Evidence from Operational Risk Events in U. S. Bank Holding Companies

How does business complexity affect risk management in financial institutions? The commonly used risk measures rely on either balance sheet or market based information, both of which may suffer from identification problems when it comes to answering this question. Balance sheet measures, such as return on assets, capture the risk when it is realized, while empirical identification requires knowledge of the risk when it is actually taken. Market based measures, such as bond yields, not only ignore the problem that investors are not fully aware of all the risks taken by management due to asymmetric information, but are also contaminated by other confounding factors such as implicit government guarantees associated with the systemic importance of complex financial institutions. To circumvent these problems, we use operational risk events as a risk management measure because (i) the timing of the origin of each event is well identified, and (ii) the risk events can serve as a direct measure of materialized failures in risk management without being influenced by the confounding factors that drive asset prices. Using the gradual deregulation of banks' nonbank activities during 1996 1999 as a natural experiment, we show that the frequency and magnitude of operational risk events in U. S. bank holding companies have increased significantly with their business complexity. This trend is particularly strong for banks that were bound by regulations beforehand, especially for those with an existing Section 20 subsidiary, and weaker for other banks that were not bound and for nonbank financial institutions that were not subject to the same regulations to begin with. These results reveal the darker side of post deregulation diversification, which in earlier studies has been shown to lead to improved stock and earnings performance. Our findings have important implications for the regulation of financial institutions deemed systemically important, a designation tied closely to their complexity by the Bank for International Settlements and the Federal Reserve.
Anticipated Earnings Announcements and the Customer Supplier Anomaly

I test whether the anticipation of earnings news stimulates acquisition of customer information and mitigates returns to the customer supplier anomaly documented by Cohen and Frazzini "Economic Links and Predictable Returns."  (2008) 1977 2011) I find that attention to a firm's publicly disclosed customers increases shortly before the firm announces earnings, and that customer stock returns predict supplier stock returns shortly before, but not after, the supplier's earnings announcement. I further find some evidence that these predictable returns are increasing in the level of customer information acquisition. These results are unique to anticipated disclosure events and suggest that anticipation of supplier earnings announcements resolves investor limited attention to customer information and accelerates price discovery of customer news.
Highway long short term memory RNNS for distant speech recognition
Venue: 2016 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

In this paper, we extend the deep long short term memory (DL STM) recurrent neural networks by introducing gated direct connections between memory cells in adjacent layers. These direct links, called highway connections, enable unimpeded information flow across different layers and thus alleviate the gradient vanishing problem when building deeper LSTMs. We further introduce the latency controlled bidirectional LSTMs (BLSTMs) which can exploit the whole history while keeping the latency under control. Efficient algorithms are proposed to train these novel networks using both frame and sequence discriminative criteria. Experiments on the AMI distant speech recognition (DSR) task indicate that we can train deeper LSTMs and achieve better improvement from sequence training with highway LSTMs (HLSTMs) Our novel model obtains 43.9/47.7% WER on AMI (SDM) dev and eval sets, outperforming all previous works. It beats the strong DNN and DLSTM baselines with 15.7% and 5.3% relative improvement respectively.
Being true to oneself: investigating celebrity brand authenticity

Celebrity brand authenticity is introduced as a construct that represents consumer perceptions of celebrities being "true to oneself" in their behaviors and interactions with consumers. A scale is developed through two purification stages and the scale's predictive validity is assessed. First, the meaning of celebrity brand authenticity to consumers is explored. Second, the Authenticity Inventory from the psychology literature is adapted to develop a scale for consumer perceptions of celebrity brand authenticity. Celebrity brands are perceived as true to self when they appear genuine in their relationships with consumers and behave in accordance with their perceived held values. Evidence of the convergent and discriminant validity of the celebrity brand authenticity scale is provided, which confirms celebrity brand authenticity as distinct from celebrity attachment, despite containing relational items. Finally, the predictive power of celebrity brand authenticity is confirmed through positively influencing consumer intentions to purchase an endorsed brand. Brand managers can use celebrity brand authenticity to position or develop celebrity brands, as well as in the selection of celebrity endorsers.