nils-herrmann/clean_scirepeval huggingface dataset:
Cells and extracellular matrix interplay in cardiac valve disease: because age matters
Venue: Basic Research in Cardiology

Cardiovascular aging is a physiological process affecting all components of the heart. Despite the interest and experimental effort lavished on aging of cardiac cells, increasing evidence is pointing at the pivotal role of extracellular matrix (ECM) in cardiac aging. Structural and molecular changes in ECM composition during aging are at the root of significant functional modifications at the level of cardiac valve apparatus. Indeed, calcification or myxomatous degeneration of cardiac valves and their functional impairment can all be explained in light of age related ECM alterations and the reciprocal interplay between altered ECM and cellular elements populating the leaflet, namely valvular interstitial cells and valvular endothelial cells, is additionally affecting valve function with striking reflexes on the clinical scenario. The initial experimental findings on this argument are underlining the need for a more comprehensive understanding on the biological mechanisms underlying ECM aging and remodeling as potentially constituting a pharmacological therapeutic target or a basis to improve existing prosthetic devices and treatment options. Given the lack of systematic knowledge on this topic, this review will focus on the ECM changes that occur during aging and on their clinical translational relevance and implications in the bedside scenario.
Aspect based opinion mining for mobile phones
Venue: 2016 2nd International Conference on Next Generation Computing Technologies (NGCT)

With the explosion of Web 2.0, platforms such as blogs, e commerce sites, peer to peer networks and social media, consumers have a broad platform and unlimited power to share their experiences in the form of reviews. With this, bulks of reviews are available for a single product, that needs to be analyzed, processed and mine.  Mining or Sentiment Analysis is a Natural Language Processing and Information retrieval task that defines the customer's views or opinions through positive, negative or neutral sentiments. Aspect based Opinion Mining deals with aspects of the features. In this paper an aspect based opinion mining system is proposed that classify reviews as positive and negative. The system also deals with two aspects in a review. Experimental results using reviews of mobile phones show an accuracy of 75% as compared to other methods.
Replacement of conventional dedusting agents with green alternatives in production of rock mineral wool insulation products

The possibility to replace commonly used dedusting agents based on mineral oil with more sustainable vegetable oils as representatives of natural and environmental friendly materials is studied. Different anionic and nonionic emulsifying additives are studied as well. The stability of binder mixtures consisting of phenol formaldehyde resin, urea, silane, and various dedusting agents is evaluated, and the adhesion of binder mixtures to the rock sand is analyzed by the sandbar test. Adequate stability of binder mixtures and high bending strength to break the bars are achieved when binder mixtures contained dedusting emulsions based on mineral or vegetable oil as well as their combination emulsified with lignosulfonate salt. The combination of mineral or vegetable oil with nonionic emulsifier on the other hand shows poor stability of binder mixtures.
Biological destabilization of wool scouring effluents

and biological treatments are techno logical alternatives, the choice of process being made mainly on economic grounds. In recent years, combinations of the pro cesses have been successfully used in which the two are usually separate steps in the purification sequence, each making its own contribution to the reduction in the pollu tion load.1 6 In the authors' investigations into the treatment of wool scouring waste liquors, considerable advantage has been found in a combined treatment in which a very rapid biological treatment is followed by a chemical flocculation. This paper shows that the biological step reduces the pollu tion load only slightly, but substantially increases the efficiency of the flocculation. The effects of varying conditions on the process are described, and a mechanism for the improvement in flocculation ef ficiency is proposed. Experimental Three different aerobic biological pro cesses were used to treat wool scouring effluents: plastic medium trickling filter, a rotating disk apparatus, and a rotating tube reactor similar to that described by Reynolds.7 Their specifications are listed in Table I. The first two were located at local wool scouring mills and the last in the laboratory. All of the units were fed with liquors obtained from the first or sec ond bowls of commercial wool scouring trains. These liquors are equal in strength to the strongest wastes normally discharged from wool scouring mills. The character istics of these liquors are shown in Table II.
TRPV4 Regulates Breast Cancer Cell Extravasation, Stiffness and Actin Cortex
Venue: Scientific reports

Metastasis is a significant health issue. The standard mode of care is combination of chemotherapy and targeted therapeutics but the 5 year survival rate remains low. New/better drug targets that can improve outcomes of patients with metastatic disease are needed. Metastasis is a complex process, with each step conferred by a set of genetic aberrations. Mapping the molecular changes associated with metastasis improves our understanding of the etiology of this disease and contributes to the pipeline of targeted therapeutics. Here, phosphoproteomics of a xenograft derived in vitro model comprising 4 isogenic cell lines with increasing metastatic potential implicated Transient Receptor Potential Vanilloid subtype 4 in breast cancer metastasis. TRPV4 mRNA levels in breast, gastric and ovarian cancers correlated with poor clinical outcomes, suggesting a wide role of TRPV4 in human epithelial cancers. TRPV4 was shown to be required for breast cancer cell invasion and transendothelial migration but not growth/proliferation. Knockdown of Trpv4 significantly reduced the number of metastatic nodules in mouse xenografts leaving the size unaffected. Overexpression of TRPV4 promoted breast cancer cell softness, blebbing, and actin reorganization. The findings provide new insights into the role of TRPV4 in cancer extravasation putatively by reducing cell rigidity through controlling the cytoskeleton at the cell cortex.
Bisulfite oligonucleotide capture sequencing for targeted base and strand specific absolute 5 methylcytosine quantitation
Venue: AGE

Epigenetic regulation through DNA methylation (5mC) plays an important role in development, aging, and a variety of diseases. Genome wide studies of base and strand specific 5mC are limited by the extensive sequencing required. Targeting bisulfite sequencing to specific genomic regions through sequence capture with complimentary oligonucleotide probes retains the advantages of bisulfite sequencing while focusing sequencing reads on regions of interest, enables analysis of more samples by decreasing the amount of sequence required per sample, and provides base and strand specific absolute quantitation of CG and non CG methylation levels. As an example, an oligonucleotide capture set to interrogate 5mC levels in all rat RefSeq gene promoter regions (18,814) and CG islands, shores, and shelves (18,411) was generated. Validation using whole genome methylation standards and biological samples demonstrates enrichment of the targeted regions and accurate base specific quantitation of CG and non CG methylation for both forward and reverse genomic strands. A total of 170 Mb of the rat genome is covered including 6.6 million CGs and over 67 million non CG sites, while reducing the amount of sequencing required by ~85 as compared to existing whole genome sequencing methods. This oligonucleotide capture targeting approach and quantitative validation workflow can also be applied to any genome of interest.
Somatic hypermutation in immunity and cancer: Critical analysis of strand biased and codon context mutation signatures.
Venue: DNA repair

For 30 years two general mechanisms have competed to explain somatic hypermutation of immunoglobulin (Ig) genes. The first, the DNA based model, is focused only on DNA substrates. The modern form is the Neuberger "DNA Deamination Model" based on activation induced cytidine deaminase (AID) and short patch error prone DNA repair by DNA Polymerase e operating around AID C to U lesions. The other is an RNA based mechanism or the "Reverse Transcriptase Model" of SHM which produces strand biased mutations at A:T and G:C base pairs. This involves error prone cDNA synthesis via an RNA dependent DNA polymerase copying the Ig pre mRNA template and integrating the now error filled cDNA copy back into the normal chromosomal site. The modern form of this mechanism depends on AID dC to dU lesions and long tract error prone cDNA synthesis of the transcribed strand by DNA Polymerase e acting as a reverse transcriptase. The evidence for and against each mechanism is critically evaluated. The conclusion is that all the SHM molecular data gathered since 1980 supports directly or indirectly the RNA/RT based mechanism. All the data and critical analyses are systematically laid out so the reader can evaluate this conclusion for themselves. Recently we have investigated whether similar RNA/RT based mutator mechanisms explain how de novo mutations arise in somatic tissues (cancer genomes) The data analyses indeed suggest that cancers arise via dysregulated "Ig like SHM responses" involving rogue DNA and RNA deaminations coupled to genome wide RT events. Further, Robyn Lindley has recently shown that the strand biased mutations in cancer genome genes are also in "codon context." This has been termed Targeted Somatic Mutation (TSM) to highlight that mutations are far more targeted than previously thought in somatic tissues associated with disease. The TSM process implies an "in frame DNA reader" whereby DNA and RNA deaminases at transcribed regions are guided in their mutagenic action, by the codon reading frame of the DNA.
A High Throughput and Multi Parallel VLSI Architecture for HEVC Deblocking Filter
Venue: IEEE Transactions on Multimedia

This paper presents a high throughput and multi parallel VLSI hardware architecture for the deblocking filter in the HEVC video coding standard. First, an implementation friendly and fast boundary judgment method is proposed to avoid using the original recursion loop approach. Then a dedicated parallel VLSI architecture composed of four parallel filtering cores is presented based on the proposed boundary judgment method. With the parallel luma/chroma filtering and parallel vertical/horizontal edges filtering order, the proposed VLSI architecture can process filtering operations for one largest coding unit (LCU) with less filtering cycles than other conventional approaches. Furthermore, filtering efficiency is improved due to a novel ping pang buffer architecture and the on chip single port SRAM with dedicated data arrangement in the memory modules. Experimental results demonstrate that the proposed deblocking filter architecture improves the performance by 28 89% at the expense of the slightly increased gate count compared to the previously known architecture in HEVC. The proposed architecture can reach a high operating clock frequency of 278 MHz with TSMC 90 nm library and meet the real time requirement of the deblocking filter for 8 K x 4 K video format at 123 frame/s.
Going Native: Effects of Disclosure Position and Language on the Recognition and Evaluation of Online Native Advertising

Despite recent industry attention, questions remain about how native advertising is perceived and processed by consumers. Two experiments examined effects of language and positioning in native advertising disclosures on recognition of the content as advertising, effects of recognition on brand and publisher evaluations, and whether disclosure position affects visual attention. Findings show that middle or bottom positioning and wording using "advertising" or "sponsored" increased advertising recognition compared to other conditions, and ad recognition generally led to more negative evaluations. Visual attention mediated the relationship between disclosure position and advertising recognition. Theoretical, practical, and regulatory implications for disclosures in native advertising are discussed.
Advertising as a cue to consume: a systematic review and meta analysis of the effects of acute exposure to unhealthy food and nonalcoholic beverage advertising on intake in children and adults.
Venue: The American journal of clinical nutrition

Several studies have assessed the effects of food and nonalcoholic beverage (hereafter collectively referred to as food) advertising on food consumption, but the results of these studies have been mixed. This lack of clarity may be impeding policy action.  We examined the evidence for a relation between acute exposure to experimental unhealthy food advertising and food consumption.  The study was a systematic review and meta analysis of published studies in which advertising exposure (television or Internet) was experimentally manipulated, and food intake was measured. Five electronic databases were searched for relevant publications (SCOPUS, PsycINFO, MEDLINE, Emerald Insight, and JSTOR) An inverse variance meta analysis was used whereby the standardized mean difference (SMD) in food intake was calculated between unhealthy food advertising and control conditions.  Twenty two articles were eligible for inclusion. Data were available for 18 articles to be included in the meta analysis (which provided 20 comparisons) With all available data included, the analysis indicated a small to moderate effect size for advertising on food consumption with participants eating more after exposure to food advertising than after control conditions (SMD: 0.37; 95% CI: 0.09; 0.65; I(2) 98% Subgroup analyses showed that the experiments with adult participants provided no evidence of an effect of advertising on intake (SMD: 0.00; P 1.00; 95% CI: 0.08, 0.08; I(2) 8% but a significant effect of moderate size was shown for children, whereby food advertising exposure was associated with greater food intake (SMD: 0.56; P 0.003; 95% CI: 0.18, 0.94; I(2) 98%  Evidence to date shows that acute exposure to food advertising increases food intake in children but not in adults. These data support public health policy action that seeks to reduce children's exposure to unhealthy food advertising.
Mobile Advertising: A Framework and Research Agenda

Mobile advertising allows retailers, service providers, and manufacturers to provide consumers with increasingly relevant offers. The success of such campaigns depends on an ever better understanding of environmental, consumer, and technological context variables; a strong focus on advertising goals; accounting for market factors related to the nature of stakeholders and market environment; and the use of appropriate mobile ad elements to improve relevant outcome metrics. This article provides an overarching framework to synthesize current findings in mobile advertising, as well as a research agenda to stimulate additional work in this nascent field.
Advertising in social media: a review of empirical evidence

This article presents an up to date review of academic and empirical research on advertising in social media. Two international databases from business and communication studies were searched, identifying 51 relevant studies. The findings of the identified studies were organized by seven emerging themes: use of advertising in social media, attitudes about and exposure to advertising, targeting, user generated content in advertising, electronic word of mouth in advertising, consumer generated advertising, and further advertising effects. Besides researched topics and major results, year of publication, journal, theoretical framework, research method, sample, measured constructs, and way of analysis were examined regarding each article. The review concludes by providing an agenda for future research.
MUKJIZAT AL QUR'AN

I'jaz al Qur'an is something extraordinary that exists in the Qur'an that weakens the human to bring forth what is like it, which contains elements that challenge will not be matched and brought by Allah. to his apostles as evidence for the validity of his treatise. Basically the miracles of the Qur'an is centered on two aspects, namely in terms of content or the content of the Qur'an and the terms of the language of the Qur'an. I'jaz Qur'an aims to prove that the Qur'an is really the revelation of Allah. not made by the angel Gabriel, and not written by Prophet Muhammad, and Prophet Muhammad which brings the miracle of the Koran's book is truly a prophet or messenger of Allah and aims to show the weakness of literary quality and balaghah human language, because it proved no match for the book that can bring the same as the Qur'an.
AL QUR'AN SEBAGAI MUKJIZAT TERBESAR

Mukjizat Nabi Muhammad Saw memiliki kekhususan dibandingkan dengan mukjizat Nabi Nabi lainnya. Semua mukjizat sebelumnya dibatasi oleh ruang dan waktu, artinya hanya diperlihatkan kepada umat tertentu dan masa tertentu. Sedangkan mukjizat al Qur"an bersifat universal dan abadi yakni berlaku untuk semua umat manusia sampai akhir zaman. Karena itu, al Qur"an adalah sebagai mukjizat terbesar dari semua mukjizat mukjizat yang diberikan Allah Swt kepada para Nabi sebelumnya dan kepada Nabi Muhammad Saw sendiri. Mukjizat mukjizat para Nabi dan Rasul terdahulu berupa mukjizat materi bersifat indrawi, tetapi mukjizat Nabi Muhammad Saw berupa mukjizat ruhiyah yang bersifat rasional, kekal sepanjang masa, yaitu al Qur"an al Karim sebagai mukjizat terbesar di antara mukjizat mukjizat yang diberikan kepadanya. Begitu pula mukjizat mukjizat yang diberikan kepada para Nabi dan Rasul sebelumnya, tidak nampak lagi fisik dan bekasnya, kecuali kisahnya saja yang dapat diketahui melalui pemberitaan al Qur"an sebagai mukjizat terbesar Nabi Muhammad Saw. Kata Kunci Al Qur"an dan Mukjizat Terbesar
Region of interest extraction for palmprint and palm vein recognition
Venue: 2016 9th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP BMEI)

The ROI (region of interest) extraction is the key step in palmprint or palm vein recognition, which is very important for the subsequent feature extraction and recognition. In this paper, the ROI extraction method for palmprint and palm vein recognition is mainly studied. Firstly, the preprocessing operation of palmprint and palm vein is carried out by using binary and morphological denoising technology, then the ROI regions are located and extracted based on the maximum inscribed circle and centroid methods. Finally, the algorithms are tested on PUT palm vein database and CASIA database, the experimental results show that the methods of this paper have a good effect, which are feasibility and validity. Furthermore, an online ROI extraction simulation system is designed in this article. The palmprint or palm vein image can be obtained in real time by using the camera through the system, then the ROI can be extracted. The simulation system is intuitive and easy to operate, which provides a reliable experimental platform for the study of palmprint and palm vein recognition technology.
The Case Study in Family Business

In this study, we identified and analyzed 75 articles in the family business (FB) literature between 2000 and 2014 as to the case study design they adopted. We found that the positivistic case study approach is the FB disciplinary convention. The two alternative approaches of critical realism and interpretivism are used to a significantly lesser extent. We anticipate that in the future the positivistic approach will continue to be used widely. The other two approaches can be employed to a higher extent since their use is likely to contribute to a scientific pluralism in FB case study research.
Learning privately from multiparty data
Venue: ICML

Learning a classifier from private data collected by multiple parties is an important problem that has many potential applications. How can we build an accurate and differentially private global classifier by combining locally trained classifiers from different parties, without access to any party's private data? We propose to transfer the `knowledge' of the local classifier ensemble by first creating labeled data from auxiliary unlabeled data, and then train a global \epsilon$ differentially private classifier. We show that majority voting is too sensitive and therefore propose a new risk weighted by class probabilities estimated from the ensemble. Relative to a non private solution, our private solution has a generalization error bounded by $O(\epsilon^ 2}M^ 2} where $M$ is the number of parties. This allows strong privacy without performance loss when $M$ is large, such as in crowdsensing applications. We demonstrate the performance of our method with realistic tasks of activity recognition, network intrusion detection, and malicious URL detection.
Development of ready to eat supplementary foods using germinated cereal pulse mix, potato flour and green leafy vegetable for malnourished children

The purpose of this paper is to develop and standardize nutrient dense, easily digestible and affordable ready to eat supplementary foods from locally available ingredients for malnourished children and to assess their nutritional composition.  To develop supplementary foods, wheat and green gram were germinated, dried and made into flour. Potatoes of "Kufri Pukhraj" variety procured from university were washed, peeled, sliced, boiled, dipped in potassium metabisulphite solution, dried and grounded into flour. Spinach leaves were washed, dried and made into powder. Five wholesome ready to eat supplementary foods, namely, panjiri, mathi, seviyan, biscuits and pinni, were developed from germinated cereal, pulse and potato flour and spinach leaves powder. The products were standardized with potato flour and spinach leaves powder. The developed products were analyzed for proximate composition by standardized methods.  One way analysis of variance and Tukey's test was used to obtain differences in organoleptic scores within different levels of treatments. All five supplementary foods were acceptable at 30 per cent level of potato flour and 2.5 per cent level of spinach leaves powder. Mean scores of panjiri, mathi, seviyan, biscuits and pinni were significantly different (p 0.05) Significant (p 0.05) difference was observed in terms of moisture, crude protein, crude fat, crude fibre and ash content among the developed products.  The developed ready to eat supplementary foods can be recommended for supplementary feeding programmes running in the country.  The paper aims at the development of high energy protein supplementary foods for malnourished children. The developed complementary food blend is made up of variety of food groups like cereal, pulse, root and tuber and green leafy vegetables to provide wholesome nutrition to children. This is different to originally provided supplementary foods to children made up of only cereal. The developed products also add a variety to supplementary foods given to malnourished children in supplementary feeding programmes.