nils-herrmann/clean_scirepeval huggingface dataset:
Community Based Participatory Research on Issues Around Palliative and End of Life Care: Literature Review

This review describes past studies that adopted the approach of community based participatory research to identify implications for future research to address palliative and end of life care needs in underserved communities. Four major databases were used to search for studies that met the inclusion criteria. A total of 18 articles published between 2000 and 2015 in scientific journals were identified and included in this review. Six themes emerged from the review of the 18 articles including end of life decision making/advanced care planning, experiences with serious illnesses, end of life views of individuals with disabilities, grief and loss, use of complementary medicine for palliative and end of life care, and community based palliative care. Communities reported in the articles varied, including racial/ethnic minorities, people with disabilities, prison inmates, patients with late stage AIDS, or volunteers serving seriously ill community members. Community members participated in many stages of the research process, generating research questions based on the community's needs, providing input in developing intervention tools, implementing interventions, collecting data, and providing guidance for future direction. Building on these past efforts, future community based participatory research studies on palliative and end of life care should include further intervention programs tailored to the needs of communities and more efforts to evaluate the effectiveness of the programs.
Candida albicans infection leads to barrier breakdown and a MAPK/NF kB mediated stress response in the intestinal epithelial cell line C2BBe1
Venue: Cellular microbiology

Intestinal epithelial cells (IEC) form a tight barrier to the gut lumen. Paracellular permeability of the intestinal barrier is regulated by tight junction proteins and can be modulated by microorganisms and other stimuli. The polymorphic fungus Candida albicans, a frequent commensal of the human mucosa, has the capacity of traversing this barrier and establishing systemic disease within the host. Infection of polarized C2BBe1 IEC with wild type C. albicans led to a transient increase of transepithelial electric resistance (TEER) before subsequent barrier disruption, accompanied by a strong decline of junctional protein levels and substantial, but considerably delayed cytotoxicity. Time resolved microarray based transcriptome analysis of C. albicans challenged IEC revealed a prominent role of NF kB and MAPK signalling pathways in the response to infection. Hence, we inferred a gene regulatory network based on differentially expressed NF kB and MAPK pathway components and their predicted transcriptional targets. The network model predicted activation of GDF15 by NF kB was experimentally validated. Furthermore, inhibition of NF kB activation in C. albicans infected C2BBe1 cells led to enhanced cytotoxicity in the epithelial cells. Taken together our study identifies NF kB activation as an important protective signalling pathway in the response of epithelial cells to C. albicans.
Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome.
Venue: The New England journal of medicine

The transfer of fresh embryos is generally preferred over the transfer of frozen embryos for in vitro fertilization (IVF) but some evidence suggests that frozen embryo transfer may improve the live birth rate and lower the rates of the ovarian hyperstimulation syndrome and pregnancy complications in women with the polycystic ovary syndrome.  In this multicenter trial, we randomly assigned 1508 infertile women with the polycystic ovary syndrome who were undergoing their first IVF cycle to undergo either fresh embryo transfer or embryo cryopreservation followed by frozen embryo transfer. After 3 days of embryo development, women underwent the transfer of up to two fresh or frozen embryos. The primary outcome was a live birth after the first embryo transfer.  Frozen embryo transfer resulted in a higher frequency of live birth after the first transfer than did fresh embryo transfer (49.3% vs. 42.0% for a rate ratio of 1.17 (95% confidence interval [CI] 1.05 to 1.31; P=0.004) Women who underwent frozen embryo transfer also had a lower frequency of pregnancy loss (22.0% vs. 32.7% for a rate ratio of 0.67 (95% CI, 0.54 to 0.83; P<0.001) and of the ovarian hyperstimulation syndrome (1.3% vs. 7.1% for a rate ratio of 0.19 (95% CI, 0.10 to 0.37; P<0.001) but a higher frequency of preeclampsia (4.4% vs. 1.4% for a rate ratio of 3.12 (95% CI, 1.26 to 7.73; P=0.009) There were no significant between group differences in rates of other pregnancy and neonatal complications. There were five neonatal deaths in the frozen embryo group and none in the fresh embryo group (P=0.06) CONCLUSIONS Among infertile women with the polycystic ovary syndrome, frozen embryo transfer was associated with a higher rate of live birth, a lower risk of the ovarian hyperstimulation syndrome, and a higher risk of preeclampsia after the first transfer than was fresh embryo transfer. (Funded by the National Basic Research Program of China and others; ClinicalTrials.gov number, NCT01841528.
Criteria, prevalence, and phenotypes of polycystic ovary syndrome.
Venue: Fertility and sterility

Polycystic ovary syndrome (PCOS) is a highly prevalent disorder effecting reproductive aged women worldwide. This article addresses the evolution of the criteria used to diagnosis PCOS; reviews recent advances in the phenotypic approach, specifically in the context of the extended Rotterdam criteria; discusses limitations of the current criteria used to diagnosis, particularly when studying adolescents and women in the peri and postmenopause; and describes significant strides made in understanding the epidemiology of PCOS. This review recognizes that although there is a high prevalence of PCOS, there is increased variability when using Rotterdam 2003 criteria, owing to limitations in population sampling and approaches used to define PCOS phenotypes. Last, we discuss the distribution of PCOS phenotypes, their morbidity, and the role that referral bias plays in the epidemiology of this syndrome.
Granulosa cell tumor of the ovary
Venue: Ci ji yi xue za zhi Tzu chi medical journal

Fig. 2. Tumor cells with nuclear grooves are present (hematoxylin eosin stain, 400) A 38 year old woman who had regular follow up for infertility and had received two failed in vitro fertilizations was examined in our clinic. She had a history of diabetes mellitus and hypertension and had surgery for a double uterus several years ago. Sonography of the right ovary revealed a 10 cm cystic tumor. Right ovarian cystectomy was performed and an ovarian cystic tumor with
CLINICAL PRACTICE. Polycystic Ovary Syndrome.
Venue: The New England journal of medicine

A 22 year old woman reports having hirsutism and irregular menses. She describes unpredictable and infrequent menses (five or six per year) since menarche at 11 years of age. Dark, coarse facial hair began to develop at 13 years of age. The symptoms worsened after she gained weight in college. The physical examination includes a body mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 29, blood pressure of 135/85 mm Hg, and moderate hirsutism without virilization. Laboratory tests reveal a total testosterone level of 65 ng per deciliter (2.3 nmol per liter) (assay reference range, 14 to 53 ng per deciliter [0.5 to 1.8 nmol per liter] calculated free testosterone level of 15.3 pg per milliliter (53.1 pmol per liter) (assay reference range, 0.6 to 6.8 pg per milliliter [2.1 to 23.6 pmol per liter] and glycated hemoglobin level of 5.7% (normal value, =5.6% How should this case be evaluated and managed?
Protective Effect of Contemporary Pertussis Vaccines: A Systematic Review and Meta analysis.
Venue: Clinical infectious diseases an official publication of the Infectious Diseases Society of America

Acellular pertussis (aP) and whole cell (wP) pertussis vaccines are presumed to have similar short term <3 years after completion of the primary series) efficacy. However, vaccine effect varies between individual pertussis vaccine formulations, and many originally studied formulations are now unavailable. An updated analysis of the short term protective effect of pertussis vaccines limited to formulations currently on the market in developed countries is needed.  We conducted a systematic review and meta analysis of published studies that evaluated pertussis vaccine efficacy or effectiveness within 3 years after completion >3 doses) of a primary series of a currently available aP or wP vaccine formulation. The primary outcome was based on the World Health Organization (WHO) clinical case definitions for pertussis. Study quality was assessed using the approach developed by the Child Health Epidemiology Research Group. We determined overall effect sizes using random effects meta analyses, stratified by vaccine (aP or wP) and study (efficacy or effectiveness) type.  Meta analysis of 2 aP vaccine efficacy studies (assessing the 3 component GlaxoSmithKline and 5 component Sanofi Pasteur formulations) yielded an overall aP vaccine efficacy of 84% (95% confidence interval [CI] 81% 87% Meta analysis of 3 wP vaccine effectiveness studies (assessing the Behringwerke, Pasteur/Merieux, and SmithKline Beecham formulations) yielded an overall wP vaccine effectiveness of 94% (95% CI, 88% 97% (bothI(2) 0% CONCLUSIONS Although all contemporary aP and wP formulations protect against pertussis disease, in this meta analysis the point estimate for short term protective effect against WHO defined pertussis in young children was lower for currently available aP vaccines than wP vaccines.
Influence of Songs in Primary School Students' Motivation for Learning English in Lima, Peru

Many studies have shown that using music and songs while learning a new language can be of great benefit to students in aspects such as grammar, pronunciation and vocabulary. However, the use of songs in class as motivation to learn English is a subject that has not been explored thoroughly. The purpose of this study is to explore how the use of songs in English helps motivating students while learning English as a Second Language (ESL) The participants were primary school students at a private school located in the Lima Metropolitan Area. This study used a mixed method design that included observations carried out by the research team and questionnaires completed by students. The results show that students are motivated to participate and become more engaged in classroom activities when songs are used in their English classes. This result was more strongly confirmed with the observations than with the questionnaires.
ENHANCING MOTIVATION IN LEARNING ENGLISH: STUDENTS IN PRIMARY SCHOOL

Motivation is the most important factor for educator in order to improve learning. A number of teachers have contributed their study how to enhance studenta??s motivation. It is one of the most important targets in daily basis. Conceptualized studenta??s learn, work effectively, drive to engage and energy, and achieve studentsa? potential at school. This paper describes the characteristics of primary students, the role of primary English teacher and focuses on the strategies of the teachers to motivate children to learn English. There are three ways to motivate children: achieving intrinsic, extrinsic and group motivation. In achieving intrinsic motivation, it is concluded that TPR, using songs and playing games are good strategies for children. Whereas, achieving extrinsic motivation, from the weakest to the strongest degree, extrinsic motivation is classified into a??external regulation, interjected regulation and identified regulationa? And the last is group motivation, group motivation plays a very important role in language teaching which occurs in the classroom. So it is wise for primary school English teachers to create an active motivational atmosphere where children feel secure to learn.
An Overview of Signal Processing Techniques for Millimeter Wave MIMO Systems
Venue: IEEE Journal of Selected Topics in Signal Processing

Communication at millimeter wave (mmWave) frequencies is defining a new era of wireless communication. The mmWave band offers higher bandwidth communication channels versus those presently used in commercial wireless systems. The applications of mmWave are immense: wireless local and personal area networks in the unlicensed band, 5G cellular systems, not to mention vehicular area networks, ad hoc networks, and wearables. Signal processing is critical for enabling the next generation of mmWave communication. Due to the use of large antenna arrays at the transmitter and receiver, combined with radio frequency and mixed signal power constraints, new multiple input multiple output (MIMO) communication signal processing techniques are needed. Because of the wide bandwidths, low complexity transceiver algorithms become important. There are opportunities to exploit techniques like compressed sensing for channel estimation and beamforming. This article provides an overview of signal processing challenges in mmWave wireless systems, with an emphasis on those faced by using MIMO communication at higher carrier frequencies.
Human skin based flexible triboelectric nanogenerator using conductive elastomer and fabric films

A single electrode based triboelectric nanogenerator (TENG) utilising a human skin as an active triboelectric layer for self powered wearable devices and electronics applications is presented. The proposed flexible TENG was fabricated by sandwiching a conductive elastomer and fabric films with polydimethylsiloxane through a simple and cost effective process. The fabricated device exhibited an average open circuit voltage and short circuit current of 107.2 V/0.32 mA/cm2 and 132 V/0.5 mA/cm2, respectively. With the integration of rectifier circuit, 4.7 mF capacitor was charged using the proposed TENG up to 6.6 V.
In Search of an Artistic Curriculum Identity

As people go through major shifts in their lives, they often refer to their experience in earlier time periods as "in a different life." This notion of disconnect between parts of one's lived experience is problematic in that it reduces imaginal sources of conception and meaning making. This chapter explores this topic by examining the use of duoethnography in a curriculum studies class. One duoethnography in the class was conducted by Lida Dekker and Melody Rasmor, titled, "Nursing an Artful Practice: Finding the Aesthetic Groundings of our Practice." In this study they examined earlier, artistic aspects of their identity, within the context of their current professional identities as nurse educators. This exploration led them to an awareness that their artistic sides, subordinated by current duties and responsibilities, were still present in their lives, contributing to their professional behavior. Stage two of the duoethnography presents a second study in which Richard Sawyer, Melody Rasmor, and Lida Dekker deconstruct the first study as text, examining it in relation to perceptions of classroom and life history curriculum. In this discussion they examine how this class based duoethnography reframed their perceptions of it as curriculum, illuminating a new process of cultural and personal imaginal reconceptualization.
Mesenchymal stem cells and immunomodulation: current status and future prospects
Venue: Cell Death and Disease

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell derived MSCs as an approach to immunomodulation therapy.
A New Molecular Design Based on Thermally Activated Delayed Fluorescence for Highly Efficient Organic Light Emitting Diodes.
Venue: Journal of the American Chemical Society

Two benzoylpyridine carbazole based fluorescence materials DCBPy and DTCBPy, bearing two carbazolyl and 4 (t butyl)carbazolyl groups, respectively, at the meta and ortho carbons of the benzoyl ring, were synthesized. These molecules show very small DEST of 0.03 and 0.04 eV and transient PL characteristics indicating that they are thermally activated delayed fluorescence (TADF) materials. In addition, they show extremely different photoluminescent quantum yields in solution and in the solid state: in cyclohexane the value are 14 and 36% but in the thin films, the value increase to 88.0 and 91.4% respectively. The OLEDs using DCBPy and DTCBPy as dopants emit blue and green light with EQEs of 24.0 and 27.2% respectively, and with low efficiency roll off at practical brightness level. The crystal structure of DTCBPy reveals a substantial interaction between the ortho donor (carbazolyl) and acceptor (4 pyridylcarbonyl) unit. This interaction between donor and acceptor substituents likely play a key role to achieve very small DEST with high photoluminescence quantum yield.
Improving sustainable supply chain management using a novel hierarchical grey DEMATEL approach

Sustainable supply chain management has been studied in the past. However, the previous studies lack proper justification for a multi criteria decision making structure of the hierarchical interrelationships in incomplete information. To fill this gap, this study proposes a hierarchical grey decision making trial and evaluation laboratory method to identify and analyze criteria and alternatives in incomplete information. Traditionally, the decision making trial and evaluation laboratory method does not address a hierarchical structure and involves incomplete information within its analytical method. However, the grey theory compensates for incomplete information. This study's purpose is to apply the proposed hierarchical structure to identify aspects of and criteria for supplier prioritization. This includes an original set of criteria for structuring the following: aspects as a sustainable plan, communities for sustainability, sustainable operational process control and sustainable certification and growth. The results present the recycle/reuse/reduce option as a tool to increase the material savings percentage, which is the top criterion for supplier selection. This study concluded that the hierarchical analytical method provides a strong basis for future academic and practitioner research.
Optimization of the plastic injection molding process using the Taguchi method, RSM, and hybrid GA PSO

This paper proposes a systematic optimization model of process parameters in plastic injection molding (PIM) Firstly, the Taguchi method is employed for experimentation and data analysis, in which the quality characteristics for the plastic injection product are length and warpage. The control factors for the process are melt temperature, injection velocity, packing pressure, packing time, and cooling time. Moreover, the signal to noise (S/N) ratio and analysis of variance (ANOVA) are used to obtain a combination of parameter settings. Experimental data are set for the response surface methodology (RSM) in order to analyze and create two quality predictors and two S/N ratio predictors. The two quality predictors are associated with genetic algorithms (GA) to search for an optimal combination of process parameters that meets multiple objective quality characteristics. Finally, four predictors are combined with the hybrid GA PSO to find the final optimal combination of process parameters. The confirmation results show that the proposed model not only enhances the stability in the injection molding process, including the quality in length and warpage, but also reduces the costs of and time spent in the PIM process.
Integrin YAP/TAZ JNK cascade mediates atheroprotective effect of unidirectional shear flow
Venue: Nature

The Yorkie homologues YAP (Yes associated protein) and TAZ (transcriptional coactivator with PDZ binding motif, also known as WWTR1) effectors of the Hippo pathway, have been identified as mediators for mechanical stimuli. However, the role of YAP/TAZ in haemodynamics induced mechanotransduction and pathogenesis of atherosclerosis remains unclear. Here we show that endothelial YAP/TAZ activity is regulated by different patterns of blood flow, and YAP/TAZ inhibition suppresses inflammation and retards atherogenesis. Atheroprone disturbed flow increases whereas atheroprotective unidirectional shear stress inhibits YAP/TAZ activity. Unidirectional shear stress activates integrin and promotes integrin Ga13 interaction, leading to RhoA inhibition and YAP phosphorylation and suppression. YAP/TAZ inhibition suppresses JNK signalling and downregulates pro inflammatory genes expression, thereby reducing monocyte attachment and infiltration. In vivo endothelial specific YAP overexpression exacerbates, while CRISPR/Cas9 mediated Yap knockdown in endothelium retards, plaque formation in ApoE mice. We also show several existing anti atherosclerotic agents such as statins inhibit YAP/TAZ transactivation. On the other hand, simvastatin fails to suppress constitutively active YAP/TAZ induced pro inflammatory gene expression in endothelial cells, indicating that YAP/TAZ inhibition could contribute to the anti inflammatory effect of simvastatin. Furthermore, activation of integrin by oral administration of MnCl2 reduces plaque formation. Taken together, our results indicate that integrin Ga13 RhoA YAP pathway holds promise as a novel drug target against atherosclerosis.
Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice
Venue: Nutrients

Lactobacillus plantarum (L. plantarum) is a well known probiotic among the ingested microorganism probiotics (i.e. ingested microorganisms associated with beneficial effects for the host) However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 x 108, or 1.03 x 109 colony forming units/kg/day, designated the vehicle, LP10 1X and LP10 5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight LP10 supplementation dose dependently increased grip strength (p 0.0001) and endurance swimming time (p 0.001) and decreased levels of serum lactate (p 0.0001) ammonia (p 0.0001) creatine kinase (p 0.0118) and glucose (p 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health promotion, performance improvement, and anti fatigue effects.