nils-herrmann/clean_scirepeval huggingface dataset:
A national scale GIS based system for modelling impacts of land use on water quality
Venue: Environ. Model. Softw.

Management of freshwater quality requires modelling tools for rapid evaluation of land use and management scenarios. This paper presents the CLUES (Catchment Land Use and Environmental Sustainability) model to address this need. CLUES provides steady state, spatially distributed, integrated catchment models tightly coupled to GIS software to predict mean annual loads of total nitrogen, total phosphorus, sediments and E.coli, and concentration of nutrients throughout New Zealand (268,000km2) with a subcatchment resolution of 0.5km2. CLUES also estimates potential nutrient concentrations for estuaries and provides key farm socio economic indicators. The model includes a user interface for study area selection, scenario creation, data geo visualisation, and export of results. It is pre populated with spatial data and parameter values for New Zealand. Evaluation of the model and a summary of applications demonstrate the tractability and utility of national scale rapid scenario assessment tools within a GIS framework. Display Omitted Stream water quality prediction at mean annual time scale throughout New Zealand at kilometre scale resolution.Rapid scenario generation and evaluation of land use change and management measures (mitigation factors, intensification).Includes links to an estuary nutrient component and simple socio economic indicators.Has a growing number of applications for catchment, regional and national scenario assessment.
Improved limits on dark matter annihilation in the Sun with the 79 string IceCube detector and implications for supersymmetry

We present an improved event level likelihood formalism for including neutrino telescope data in global fits to new physics. We derive limits on spin dependent dark matter proton scattering by employing the new formalism in a re analysis of data from the 79 string IceCube search for dark matter annihilation in the Sun, including explicit energy information for each event. The new analysis excludes a number of models in the weak scale minimal supersymmetric standard model (MSSM) for the first time. This work is accompanied by the public release of the 79 string IceCube data, as well as an associated computer code for applying the new likelihood to arbitrary dark matter models.
Remediation of sewage and industrial effluent using bacterially assisted floating treatment wetlands vegetated with Typha domingensis.
Venue: Water science and technology a journal of the International Association on Water Pollution Research

This investigation reports the quantitative assessment of endophyte assisted floating treatment wetlands (FTWs) for the remediation of sewage and industrial wastewater. Typha domingensis was used to vegetate FTWs that were subsequently inoculated with a consortium of pollutant degrading and plant growth promoting endophytic bacteria. T. domingensis, being an aquatic species, holds excellent potential to remediate polluted water. Nonetheless, investigation conducted on Madhuana drain carrying industrial and sewage water from Faisalabad City revealed the percentage reduction in chemical oxygen demand (COD) and biochemical oxygen demand (BOD5) to be 87% and 87.5% respectively, within 96 h on coupling the plant species with a consortium of bacterial endophytes. With the endophytes surviving in plant tissue, maximal reduction was obtained in not only the aforementioned pollution parameters but for other major environmental quality parameters including nutrients (N and P) ions (Na+ and K+ Cl and SO42 as well, which showed percentage reductions up to 90% 39% 77% 91.8% 40% and 60% respectively. This significant improvement in polluted wastewater quality treated with the proposed method render it safe to be discharged freely in larger water bodies as per the National Environmental Quality Standards (NEQS) of Pakistan or to be reused safely for irrigation purposes; thus, FTWs provide a sustainable and affordable approach for in situ remediation of sewage and industrial wastewater.
Genetic markers for detection of Escherichia coli K 12 harboring ampicillin resistance plasmid from an industrial wastewater treatment effluent pond.
Venue: Genetics and molecular research GMR

Biotechnology industries that use recombinant DNA technology are potential sources for release of genetically modified organisms to the environment. Antibiotic resistance marker genes are commonly used for recombinant bacteria selection. One example is the marker gene coding for b lactamase (bla) in plasmids found in Escherichia coli K 12. The aim of this study was to provide an approach to develop a molecular method for genetic marker detection in E. coli K 12 harboring bla genes from an industrial wastewater treatment effluent pond (IWTEP) For the detection of bla and Achromobacter lyticus protease I (api) genes in samples from IWTEP, we employed multiplex polymerase chain reaction (PCR) using E. coli K 12 genetic marker detection primers, previously described in the literature, and primers designed in our laboratory. The microbiological screening method resulted in 22 bacterial colony forming units isolated from three different IWTEP harvesting points. The multiplex PCR amplicons showed that five isolates were positive for the bla gene marker and negative for the E. coli K 12 and api genes. The 16S rRNA regions of positive microorganisms carrying the bla gene were genotyped by the MicroSeq(r)500 system. The bacteria found were Escherichia spp (3/5) Chromobacterium spp (1/5) and Aeromonas spp (1/5) None of the 22 isolated microorganisms presented the molecular pattern of E. coli K 12 harboring the bla gene. The presence of microorganisms positive for the bla gene and negative for E. coli K 12 harboring bla genes at IWTEP suggests that the ampicillin resistance found in the isolated bacteria could be from microorganisms other than the E. coli K 12 strain harboring plasmid.
Anaerobic membrane bioreactors a mini review with emphasis on industrial wastewater treatment: applications, limitations and perspectives

AbstractAnaerobic membrane bioreactors (AnMBRs) are increasingly being used in industrial wastewater treatment as the technology represents a cost effective alternative to that based on aerobic processes. Not only AnMBRs are highly efficient in reducing chemical oxygen demand but the organic matter removed is transformed into a useful energy source biogas. AnMBRs produce effluent that is free of solids and pathogens and rich in nutrients, while occupying a small footprint. As the membrane retains biomass, AnMBRs enhance performance when dealing with inhibitory or toxic substrates, typical of industrial wastewaters. Some drawbacks remain, however, including membrane fouling and its associated effects as well as poor efficiency at lower temperature (AnMBRs are usually operated at mesophilic or thermophilic conditions) Further research is needed on lowering hydraulic retention time, removal of nutrients, removal of specific micro pollutants, establishing quantitative mass and energy/economic balances and in.
Advanced treatment of effluents from an industrial park wastewater treatment plant by ferrous ion activated persulfate oxidation process.
Venue: Water science and technology a journal of the International Association on Water Pollution Research

The advanced oxidation technology, ferrous ion (Fe(II) activated persulfate (PS) producing sulfate radicals, was used for the advanced treatment of effluent from an integrated wastewater treatment plant in a papermaking industrial park. Separate and interactive effects of PS dosage, Fe(II)/PS ratio and initial pH on chemical oxygen demand (COD) removal were analyzed by the response surface methodology (RSM) The results showed that Fe(II) PS system was effective in COD removal from the secondary effluent. PS dosage was the most dominant factor with positive influence on COD removal, followed by initial pH value. The optimum conditions with COD removal of 54.4% were obtained at PS/COD of 2.2, initial pH of 6.47 and Fe(II)/PS of 1.89. UV visible spectrum analysis showed that after RSM optimization, Fe(II) PS system effectively degraded large organic molecules into small ones, and decreased humification degree of the effluent. Three dimensional fluorescence analysis demonstrated that aromatic protein and fulvic substances were fully decomposed by the Fe(II) PS treatment.
Flavonoid gastrointestinal mucus interaction and its potential role in regulating flavonoid bioavailability and mucosal biophysical properties

Flavonoid bioavailability has attracted a lot of attention over the last decade due to the increasing evidence of their health promoting properties. However, conflicting results appear in the literature, especially on the bioavailability of flavonoid glycosides in vitro versus in vivo. In in vitro studies, where Caco 2 cells are usually used, hydrophobic aglycones have been reported to be more bioavailable. On the contrary, in vivo studies suggest that increasing the aqueous solubility of flavonoids favors their bioavailability. In this paper, we aim to fill this gap by analyzing the role of the gastrointestinal mucus on flavonoid bioavailability. Mucus is a complex viscoelastic barrier that serves as the first line of defense against pathogens, particles and several toxins, while allowing nutrients to penetrate through and reach the epithelia. A mechanism by which mucus participates in flavonoid absorption is proposed. Also, the effect of flavonoids on the biophysical properties of the mucus layer is discussed. This article therefore reviews the complex interaction between flavonoids and mucus for the first time.
Positive Psychology Perspectives on Foreign Language Learning and Teaching

Language education today draws on the developments in the so called positive psychology to create difficulty free learning contexts. Teacher training in particular shows signs of looking to the new branch of psychology as a way to eliminate problems and achieve success linked to learners' engagement and self regulation. Success in language learning is naively expected to take place only when the student's attitude is favourable, internal motivation secured and high self esteem guaranteed. This idealistic approach leads to delegating full responsibility to unprepared learners and informing them that positive feelings are the only path to greater proficiency. The present text arises from a suspicion that the current SLA/FLT approach misrepresents positive psychology by introducing unnecessary simplifications, while positive psychology research has a lot more to offer. The paper goes on to look at what mythology and religion in the past as well as psychology and sociology today tell us about seeking values in obstacles and understanding multiple functions and diverse effects of positive and negative affect. Stages of identifying obstacles and coping with difficulty are then discussed as well as ways of supporting students facing challenges in the process of language learning. Implications for teacher development are then sought in order to enable teachers to contribute to learner growth both in and through education.
Robot assisted post stroke motion rehabilitation in upper extremities: a survey

Recent neurological research indicates that the impaired motor skills of post stroke patients can be enhanced and possibly restored through task oriented repetitive training. This is due to neuroplasticity the ability of the brain to change through adulthood. Various rehabilitation processes have been developed to take advantage of neuroplasticity to retrain neural pathways and restore or improve motor skills lost as a result of stroke or spinal cord injuries (SCI) Research in this area over the last few decades has resulted in a better understanding of the dynamics of rehabilitation in post stroke patients and development of auxiliary devices and tools to induce repeated targeted body movements. With the growing number of stroke rehabilitation therapies, the application of robotics within the rehabilitation process has received much attention. As such, numerous mechanical and robot assisted upper limb and hand function training devices have been proposed. A systematic review of robotic assisted upper extremity (UE) motion rehabilitation therapies was carried out in this study. The strengths and limitations of each method and its effectiveness in arm and hand function recovery were evaluated. The study provides a comparative analysis of the latest developments and trends in this field, and assists in identifying research gaps and potential future work.
Immediate implant placement with simultaneous guided bone regeneration in the esthetic zone: 10 year clinical and radiographic outcomes.
Venue: Clinical oral implants research

To associate the dimension of the facial bone wall with clinical, radiological, and patient centered outcomes at least 10 years after immediate implant placement with simultaneous guided bone regeneration in a retrospective study.  Primary endpoint was the distance from the implant shoulder (IS) to the first bone to implant contact (IS BIC10y Secondary endpoints included the facial bone thickness (BT10y 2, 4, and 6 mm apical to the IS, and the implant position. At baseline, the horizontal defect width (HDWBL from the implant surface to the alveolar wall was recorded. At recall, distance from the IS to the mucosal margin (IS MM10y degree of soft tissue coverage of the mesial and distal aspects of the implants (PISm10y PISd10y Papilla Index) pocket probing depth (PPD10y and patient centered outcomes were determined. Width of the keratinized mucosa (KM) Full Mouth Plaque and Bleeding Score (FMPS, FMBS) were available for both time points.  Of the 20 patients who underwent immediate implant placement with simultaneous guided bone regeneration and transmucosal healing, nine males and eight females with a median age of 62 years (42 min, 84 max) were followed up for a median period of 10.5 y (min 10.1 max 11.5) The 10 year implant survival rate was 100% Multivariate regression analysis revealed a correlation of the IS BIC10y controlled for age and gender, with four parameters: HDWBL (P 0.03) KMBL 10 (P 0.02) BT10 4 mm (P 0.01) and BT10 6 mm (P 0.01) CONCLUSION Within the conditions of the present study, the horizontal defect width was the main indicator for the vertical dimension of the facial bone. The facial bone dimension was further associated with a reduction in the width of the keratinized mucosa and the dimension of the buccal bone.
The Effect of Subepithelial Connective Tissue Graft Placement on Esthetic Outcomes After Immediate Implant Placement: Systematic Review.
Venue: Journal of periodontology

Immediate implantation, despite many advantages, carries a risk of gingival recession, papilla loss, collapse of ridge contour, and other esthetic complications. Soft tissue graft placement combined with immediate implantation may be used to reduce these concerns. This review aims to systematically analyze clinical esthetic outcomes of the immediate implant combined with soft tissue graft (IMITG) METHODS The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta Analyses) guidelines for systematic reviews were used. The electronic search was conducted using MEDLINE (PubMed) EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from January 1980 to October 2014. Quality assessments of selected articles were performed. Mid buccal gingival level, interproximal gingival level, facial gingival thickness, gingival ridge dimension, and width of keratinized gingiva were the esthetic outcomes reviewed. Weighted mean difference of mid buccal gingival level (WDBGL) papilla index score (WDPIS) and width of keratinized gingiva (WDKG) between initial and last measurements were calculated. Other esthetic outcomes were assessed by the descriptive analysis.  Ten studies with a minimum of 6 month follow up were included, and reported esthetic outcomes were analyzed. Mid buccal gingival level (WDBGL, 0.07 mm; 95% confidence interval [CI] 0.44 to 0.59; P 0.12) and interproximal gingival level did not significantly change after IMITG (WDPIS in the mesial site, 0.31; 95% CI 0.01 to 0.64; P 0.06; and WDPIS in the distal site, 0.29; 95% CI 0.06 to 0.65; P 0.11) Width of keratinized gingiva significantly increased after IMITG (WDKG, 1.27 mm; 95% CI 0.08 to 2.46; P 0.04) Facial gingival thickness and gingival ridge dimension could be increased after IMITG.  Because of the heterogeneity and limited number of selected studies, no conclusive statement could be made regarding the benefit of IMITG on esthetic outcomes. More randomized controlled trials are needed to provide definite clinical evidence.
Pro and anticoagulant properties of factor V in pathogenesis of thrombosis and bleeding disorders
Venue: International journal of laboratory hematology

Factor V (FV) serves an important role in the regulation of blood coagulation, having both pro and anticoagulant properties. The circulating high molecular weight single chain FV molecule undergoes a series of proteolytic cleavages during both activation of coagulation and during anticoagulant regulation of coagulation by activated protein C (APC) It is noteworthy that mutations in the factor V gene (F5) either cause thrombosis or bleeding. New insights into the importance and complexity of FV functions have been generated from elucidation of the pathogenic mechanisms of two familial mutations in the F5 gene. The first mutation was identified as a result of the discovery of APC resistance as the most common risk factor for venous thrombosis. The mutation (FV Leiden) predicts the Arg506Gln replacement, which impairs the normal regulation of FVa by APC, as the Arg506 site is an important APC cleavage site. In addition, elucidation of APC resistance resulted in the discovery of the anticoagulant APC cofactor activity of FV. The second FV mutation (FVA2440G) identified in a family with an autosomal dominant bleeding disorder, has led to the discovery of an alternative splicing generating a previously unidentified FV isoform (FV Short) which inhibits coagulation via an unexpected and intriguing mechanism involving the coagulation inhibitor TFPI a. These are naturally occurring mutations in the F5 gene that have generated new knowledge on the role of FV in regulation of coagulation and the importance of genetic risk factors for thrombosis and bleeding.
Diagnosis and management of factor V Leiden
Venue: Expert review of hematology

The discovery of the factor V Leiden (FVL) missense mutation (Arg506Gln) causing factor V resistance to the anticoagulant action of activated protein C was a landmark that allowed a better understanding of the basis of inherited thrombotic risk. FVL mutation is currently the most common known hereditary defect predisposing to venous thrombosis.  Novel data driven FVL diagnosis and therapeutic approaches in the management of FVL carriers in various clinical settings. Brief conclusions on topics of direct clinical relevance including currently available indications for primary and secondary prophylaxis, the management of female, pediatric carriers and asymptomatic relatives. Latest evidence on the association between FVL and cancer, as well as the possible use of direct oral anticoagulant therapy.  Although FVL diagnosis nowadays is highly accurate, many doubts remain regarding the best management and therapeutic protocols. The main role of clinicians is to tailor therapeutic strategies to carriers and their relatives. High familial penetrance, distinctive aspects of the first thrombotic event (provoked/unprovoked, age, etc. and laboratory biomarkers can guide the optimal management of secondary antithrombotic prophylaxis, primary prophylaxis in asymptomatic individuals, and whether to screen relatives.
The effect of a Ta oxygen scavenger layer on HfO2 based resistive switching behavior: thermodynamic stability, electronic structure, and low bias transport.
Venue: Physical chemistry chemical physics PCCP

Reversible resistive switching between high resistance and low resistance states in metal oxide metal heterostructures makes them very interesting for applications in random access memories. While recent experimental work has shown that inserting a metallic "oxygen scavenger layer" between the positive electrode and oxide improves device performance, the fundamental understanding of how the scavenger layer modifies the heterostructure properties is lacking. We use density functional theory to calculate thermodynamic properties and conductance of TiN/HfO2/TiN heterostructures with and without a Ta scavenger layer. First, we show that Ta insertion lowers the formation energy of low resistance states. Second, while the Ta scavenger layer reduces the Schottky barrier height in the high resistance state by modifying the interface charge at the oxide electrode interface, the heterostructure maintains a high resistance ratio between high and low resistance states. Finally, we show that the low bias conductance of device on states becomes much less sensitive to the spatial distribution of oxygen removed from the HfO2 in the presence of the Ta layer. By providing a fundamental understanding of the observed improvements with scavenger layers, we open a path to engineer interfaces with oxygen scavenger layers to control and enhance device performance. In turn, this may enable the realization of a non volatile low power memory technology with concomitant reduction in energy consumption by consumer electronics and offering significant benefits to society.
Physical modelling of the SET/RESET characteristics and analog properties of TiOx/HfO2 x/TiOx based RRAM devices
Venue: 2016 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD)

Understanding the origins of switching effect is of great importance, since it can enlighten our perspectives and offers guidance for novel device design. In contrast with the common electronic devices which rely their operation only at electron transport properties, resistive switching effect exhibits a strong dependence from the local distribution of ions. Here, we present a quantitative analysis, both at DC and AC domains, which can account for the analog properties of our trilayer based devices. Our approach can capture the gradual SET/RESET responses, which stem from the balance between drift and diffusion effect, and highlight the crucial role of temperature, electric field and oxygen vacancy density on the switching pattern.
pH Triggered Sustained Drug Delivery from a Polymer Micelle having the b Thiopropionate Linkage.
Venue: Macromolecular rapid communications

The synthesis, micellar aggregation, and pH triggered intracellular drug delivery ability of an amphiphilic statistical copolymer (P2) are studied. Two methacrylate derivatives, one containing a hydrophilic pendant and the other containing a hydrophobic pendant chain, are copolymerized to produce P2. The hydrophobic pendant chain is linked to the polymer backbone by a b thiopropionate linkage, known to undergo slow hydrolysis at mild acidic pH. P2 forms a multimicellar cluster in water with a critical aggregation concentration of 0.02 mg mL( 1) and encapsulates a hydrophobic guest such as pyrene, Nile red, or the anti cancer drug doxorubicin (Dox) Sustained release of the entrapped Dox (80% after 100 h) is noticed at pH 5.2, while release is significantly slower (35% after 100 h) at pH 7.4. Acidic hydrolysis of the b thiopropionate linkage leading to the reduction of the hydrophobicity is established as the cause for micellar disassembly and triggered drug release. Cell culture studies with the human breast cancer cell line, MCF 7, reveal biocompatibility of P2 (below 150 mg mL( 1) It is further tested for intracellular delivery of Dox. MCF 7 cells remain healthy at pH 7.4 but become unhealthy at pH 5.2 when treated with a Dox loaded P2 micelles.