nils-herrmann/clean_scirepeval huggingface dataset:
The Digital Economy the various ways to the effective use of technology (BIM, PLM, CAD, IOT, Smart City, BIG DATA, and others)

The rapid development of the "digitization" of the economy has created the illusion that it is enough to use one or some of technologies, and everything goes well. However, in practice implementations, it becomes clear that only a comprehensive approach, with a coherent use of some core technologies can achieve the intended effect. The same is true for the modernization of the legislative framework. The article discusses the candidates for these key solutions and steps to get the benefits of a digital economy through the usage of information technology.
Tsifrovaia ekonomika razlichnye puti k effektivnomu primeneniiu tekhnologii (BIM, PLM, CAD, IOT, Smart City, BIG DATA i drugie)

Burnoe razvitie <tsifrovizatsii> ekonomiki porodilo illiuzii, chto dostatochno vnedreniia kakoi to odnoi tekhnologii, i vse poidet kak nado. Prakticheskie zhe resheniia pokazyvaiut, chto tol'ko kompleksnyi podkhod, s soglasovannym i odnovremennym primeneniem neskol'kikh, no kliuchevykh tekhnologii daet ozhidaemyi effekt. Eto zhe iavliaetsia vernym i dlia sfery modernizatsii zakonodatel'noi bazy. V stat'e obsuzhdaiutsia kandidaty na eti kliuchevye pozitsii i shagi po realizatsii preimushchestv tsifrovoi ekonomiki za schet primeneniia informatsionnykh tekhnologii.
A Review of Research on Improvement and Optimization of Performance Measures for Electrical Discharge Machining

Electrical Discharge Machining (EDM) is a non conventional machining method which can be used to machine electrically conductive work pieces irrespective of their shape, hardness and toughness. High cost of non conventional machine tools, compared to conventional machining, has forced us to operate these machines as efficiently as possible in order to reduce production cost and to obtain the required reimbursement. To achieve this task, machining parameters such as pulse on time, pulse off time, discharge current, gap voltage, flushing pressure, electrode material, etc. of this process should be selected such that optimal value of their performance measures like Material Removal Rate (MRR) Surface Roughness (SR) Electrode/Tool Wear Rate (EWR/TWR) dimensional accuracy, etc. can be obtained or improved. In past decades, intensive research work had been carried out by different researchers for improvement and optimization of EDM performance measures using various optimization techniques like Taguchi, Response Surface Methodology (RSM) Artificial Neural Network (ANN) Genetic Algorithm (GA) etc. This paper reviews research on improvement and optimization of various performance measures of spark erosion EDM and finally lists down certain areas that can be taken up for further research in the field of improvement and optimization for EDM process.
A Big Five approach to self regulation: personality traits and health trajectories in the Hawaii longitudinal study of personality and health
Venue: Psychology, health medicine

Self regulatory processes influencing health outcomes may have their origins in childhood personality traits. The Big Five approach to personality was used here to investigate the associations between childhood traits, trait related regulatory processes and changes in health across middle age. Participants (N 1176) were members of the Hawaii longitudinal study of personality and health. Teacher assessments of the participants' traits when they were in elementary school were related to trajectories of self rated health measured on 6 occasions over 14 years in middle age. Five trajectories of self rated health were identified by latent class growth analysis: Stable Excellent, Stable Very Good, Good, Decreasing and Poor. Childhood Conscientiousness was the only childhood trait to predict membership in the Decreasing class vs. the combined healthy classes (Stable Excellent, Stable Very Good and Good) even after controlling for adult Conscientiousness and the other adult Big Five traits. The Decreasing class had poorer objectively assessed clinical health measured on one occasion in middle age, was less well educated, and had a history of more lifespan health damaging behaviors compared to the combined healthy classes. These findings suggest that higher levels of childhood Conscientiousness (i.e. greater self discipline and goal directedness) may prevent subsequent health decline decades later through self regulatory processes involving the acquisition of lifelong healthful behavior patterns and higher educational attainment.
FDG PET CT for solitary pulmonary nodule and lung cancer: Literature review.
Venue: Diagnostic and interventional imaging

The investigation of solitary pulmonary nodule (SPN) and non small cell lung cancer (NSCLC) has rapidly become one of the main indications for 18F fluorodeoxyglucose (FDG) positron emission tomography (PET) currently combined with computed tomography (PET CT) In this literature review, we first attempt to clarify how PET imaging contributes to investigating SPN, in conjunction with conventional CT. We highlight the prospects of research underway to improve our understanding of SPN. In the second part of this review, we analyze the current role of PET CT in the overall care process for lung cancer. We review the indications for which consensus has been reached, for example initial staging, as well as new indications such as radiation therapy planning or prognostic assessment.
Urine TMPRSS2: ERG Fusion Transcript as a Biomarker for Prostate Cancer: Literature Review.
Venue: Clinical genitourinary cancer

Prostate cancer (PCa) is one of the most common male malignancies. Serum prostate specific antigen (PSA) is one of the most valuable biomarkers in tumor biology and remains the standard marker in detecting and monitoring PCa. However, the high number of serum PSA false positive and false negative results make the identification of novel biomarkers extremely welcome to improve our diagnostic accuracy in detecting PCa and distinguishing the aggressive from the indolent ones. In this study, we analyzed the current role of urinary gene fusion transcripts involving v ets erythroblastosis virus E26 oncogene homolog, commonly known as ERG, and the androgen regulated gene transmembrane protease, serine 2 (TMPRSS2) as a biomarker for PCa. Used as a single marker, urinary TMPRSS2:ERG has low sensitivity but high specificity. However, its combination with the other urinary marker PCa antigen 3 (PCA3) has been reported to provide high specificity and sensitivity. Finally, a commercially available assay combining serum PSA with urinary PCA3 and TMPRSS2:ERG provides a 90% specificity and 80% sensitivity in diagnosing PCa. Urinary TMPRSS2:ERG also seems to be indicative of PCa aggressiveness upon biopsy. Should these findings be confirmed in larger studies, urinary TMPRSS2:ERG might become a valuable test not only for diagnosing PCa but also for distinguishing the aggressive tumors from the indolent ones.
Radiation therapy for breast cancer: Literature review.
Venue: Medical dosimetry official journal of the American Association of Medical Dosimetrists

Concave shape with variable size target volume makes treatment planning for the breast/chest wall a challenge. Conventional techniques used for the breast/chest wall cancer treatment provided better sparing of organs at risk (OARs) with poor conformity and uniformity to the target volume. Advanced technologies such as intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) improve the target coverage at the cost of higher low dose volumes to OARs. Novel hybrid techniques present promising results in breast/chest wall irradiation in terms of target coverage as well as OARs sparing. Several published data compared these technologies for the benefit of the breast/chest wall with or without nodal volumes. The aim of this article is to review relevant data and identify the scope for further research in developing optimal treatment plan for breast/chest wall cancer treatment.
Structural Studies of Lipopolysaccharide defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence*
Venue: The Journal of Biological Chemistry

The structures of the lipooligosaccharides from Brucella melitensis mutants affected in the WbkD and ManBcore proteins have been fully characterized using NMR spectroscopy. The results revealed that disruption of wbkD gives rise to a rough lipopolysaccharide (R LPS) with a complete core structure (b d Glcp (1 4) a Kdop (2 4)[b d GlcpN (1 6) b d GlcpN (1 4)[b d GlcpN (1 6) b d GlcpN (1 3) a d Manp (1 5) a Kdop (2 6) b d GlcpN3N4P (1 6) a d GlcpN3N1P) in addition to components lacking one of the terminal b d GlcpN and/or the b d Glcp residues (48 and 17% respectively) These structures were identical to those of the R LPS from B. melitensis EP, a strain simultaneously expressing both smooth and R LPS, also studied herein. In contrast, disruption of manBcore gives rise to a deep rough pentasaccharide core (b d Glcp (1 4) a Kdop (2 4) a Kdop (2 6) b d GlcpN3N4P (1 6) a d GlcpN3N1P) as the major component (63% as well as a minor tetrasaccharide component lacking the terminal b d Glcp residue (37% These results are in agreement with the predicted functions of the WbkD (glycosyltransferase involved in the biosynthesis of the O antigen) and ManBcore proteins (phosphomannomutase involved in the biosynthesis of a mannosyl precursor needed for the biosynthesis of the core and O antigen) We also report that deletion of B. melitensis wadC removes the core oligosaccharide branch not linked to the O antigen causing an increase in overall negative charge of the remaining LPS inner section. This is in agreement with the mannosyltransferase role predicted for WadC and the lack of GlcpN residues in the defective core oligosaccharide. Despite carrying the O antigen essential in B. melitensis virulence, the core deficiency in the wadC mutant structure resulted in a more efficient detection by innate immunity and attenuation, proving the role of the b d GlcpN (1 6) b d GlcpN (1 4)[b d GlcpN (1 6) b d GlcpN (1 3) a d Manp (1 5) structure in virulence.
Cultural Trauma and the Media

In recent decades, cultural trauma has become a widely accepted form of collective identity in images and narratives transmitted through mass media and information networks. The idea of cultural trauma can be traced at least back to Freud and has been associated with many events including the Holocaust and 9/11. Cultural trauma narratives tell stories about heroes and martyrs but this can falsify the reality of modern mass death in which most individuals are given no opportunity to act heroically. The essay explains the development of cultural trauma as a concept over the past 100 years and how this idea became linked with visual media. The essay argues that cultural trauma has been aligned with the perceptual habits and psychological reflexes of the media viewer through the experience of shock. Cultural trauma is a new experience of collective identity in a technologically mediated society. The essay also considers the political implications of this mediated experience of trauma.
Media traumatization, symbolic wounds and digital culture

Do media images really traumatize the public? If they do not, then why do so many commentators from those commemorating the Holocaust to those analysing the impact of 9/11 claim that trauma can be transmitted to specific ethnic groups or entire societies? While these claims can be based on empirical data or used to justify political agendas, psychoanalysis also continues to influence conceptions of collective trauma and to offer important perspectives for evaluating these conceptions. This paper explores these questions of mediated trauma and collective identity by tracing a neglected historical trajectory back to the work of psychoanalyst and anthropologist Geza Roheim. Roheim produced studies of Australian Aboriginal culture that applied the theory of collective trauma outlined in Freud's Totem and Taboo. He also produced an ethnographic film, Subincision, documenting an initiation rite, that was subsequently used in psychological studies of so called "stress films" Putting aside Roheim's psychoanalytic interpretations of indigenous culture, psychologists used his film to measure the impact of images of violence and pain. These studies from the 1960s have recently been rediscovered by scholars of Holocaust film and video testimony. This paper seeks to recover the concept of "symbolic wounds" developed in psychoanalyst Bruno Bettelheim's later commentary on Roheim's work. The mass media of newspapers, film and television have supported the idea of cultural trauma shared by large societies. The concept of symbolic wounds that enhance group membership and mobilize collective action may be more useful for understanding how violent and shocking images are put to more diverse uses in digital culture.
Fast parallel skew and prefix doubling suffix array construction on the GPU
Venue: Concurr. Comput. Pract. Exp.

Suffix arrays are fundamental full text index data structures of importance to a broad spectrum of applications in such fields as bioinformatics, Burrows Wheeler transform based lossless data compression, and information retrieval. In this work, we propose and implement two massively parallel approaches on the graphics processing unit (GPU) based on two classes of suffix array construction algorithms. The first, parallel skew, makes algorithmic improvements to the previous work of Deo and Keely to achieve a speedup of 1.45x over their work. The second, a hybrid skew and prefix doubling implementation, is the first of its kind on the GPU and achieves a speedup of 2.3 4.4x over Osipov's prefix doubling and 2.4 7.9x over our skew implementation on large datasets. Our implementations rely on two efficient parallel primitives, a merge and a segmented sort. We theoretically analyze the two formulations of suffix array construction algorithms and show performance comparisons on a large variety of practical inputs. We conclude that, with the novel use of our efficient segmented sort, prefix doubling is more competitive than skew on the GPU. We also demonstrate the effectiveness of our methods in our implementations of the Burrows Wheeler transform and in a parallel full text, minute space index for pattern searching.
Generation of the first PALSAR 2 global mosaic 2014/2015 and change detection between 2007 and 2015 using the PALSAR and PALSAR 2
Venue: 2016 IEEE International Geoscience and Remote Sensing Symposium (IGARSS)

Decreasing the carbon emission from the deforestation and forest degradation is one of the issues that the humans need to tag for sustaining the Earth. Monitoring the forest from the space is the recent achievements that the space agencies contribute. Measuring the forest cover change is being conducted by using the high resolution optical and/or SAR images. ALOS 2 has been on orbit carrying the L band SAR since May 24, 2014. After more than one year data acquisition and related processing, the first version of the 25 m resolution global PALSAR 2 mosaic dataset from the 2014 2015 acquisitions, forest non forest map, and the forest cover change from 2007 to 2015 were generated.
DENSE 3D POINT CLOUD GENERATION FROM UAV IMAGES FROM IMAGE MATCHING AND GLOBAL OPTIMAZATION

3D spatial information from unmanned aerial vehicles (UAV) images is usually provided in the form of 3D point clouds. For various UAV applications, it is important to generate dense 3D point clouds automatically from over the entire extent of UAV images. In this paper, we aim to apply image matching for generation of local point clouds over a pair or group of images and global optimization to combine local point clouds over the whole region of interest. We tried to apply two types of image matching, an object space based matching technique and an image space based matching technique, and to compare the performance of the two techniques. The object space based matching used here sets a list of candidate height values for a fixed horizontal position in the object space. For each height, its corresponding image point is calculated and similarity is measured by grey level correlation. The image space based matching used here is a modified relaxation matching. We devised a global optimization scheme for finding optimal pairs (or groups) to apply image matching, defining local match region in image or object space, and merging local point clouds into a global one. For optimal pair selection, tiepoints among images were extracted and stereo coverage network was defined by forming a maximum spanning tree using the tiepoints. From experiments, we confirmed that through image matching and global optimization, 3D point clouds were generated successfully. However, results also revealed some limitations. In case of image based matching results, we observed some blanks in 3D point clouds. In case of object space based matching results, we observed more blunders than image based matching ones and noisy local height variations. We suspect these might be due to inaccurate orientation parameters. The work in this paper is still ongoing. We will further test our approach with more precise orientation parameters.
Registering Retinal Vessel Images from Local to Global via Multiscale and Multicycle Features
Venue: 2016 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)

We propose a comprehensive method using multiscale and multicycle features for retinal vessel image registration with a local and global strategy. The multiscale vessel maps generated by multiwavelet kernels and multiscale hierarchical decomposition contain segmentation results at varying image resolutions in different levels of vessel details. Then the multicycle feature composed of various combinations of cycle structures with different numbers of vertices is extracted. The cycle structure consisting of vessel bifurcation points, crossover points of arteries and veins, and the connected vessels can be found by our Angle based Depth First Search (ADFS) algorithm. Local initial registration is implemented by the matched Cycle Vessel feature points and global final registration is completed by the Cycle Vessel Bifurcation feature points using similarity transformation. Finally, our Skeleton Alignment Error Measure (SAEM) is calculated for optimal scale and cycle feature selection, yielding the best registration result intelligently. Experimental results show that our method outperforms state of the art methods on retinal vessel image registration using different features in terms of accuracy and robustness.
Learning From Critical Collective Spaces: Reflections on the Community Diversity Dialectic in Safe Spaces

Safe spaces have the potential to become prefigurative groups that aim to create social change. The idea of a safe space as a place separate and sheltered from dominant culture to mobilize for social change has gained traction in a number of academic and practical areas. However, safe spaces have the ability to be both progressive and regressive. To guide our discussion we utilize the concept of community diversity dialectic to address the tension between these forces within two settings. First we discuss research in an upper level college course rooted in feminist praxis. Then we discuss a faith community's use of adaptive liturgy with parishioners with intellectual disabilities. Following this discussion, we offer a new term, "critical collective spaces" to better capture the work done in these spaces. We offer this alternative label to move popular and academic discourse away from debating about how "safe" these spaces are (or are not) and toward a more nuanced discussion of the community diversity dialectic and other tensions within these spaces. Our overall intention is to generate dialogue on the regressive and progressive aspects of these locations and to inform the activism and community building process within prefigurative politics more broadly.
A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Venue: Cancer cell

Half of all human cancers lose p53 function by missense mutations, with an unknown fraction of these containing p53 in a self aggregated amyloid like state. Here we show that a cell penetrating peptide, ReACp53, designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines and in organoids derived from high grade serous ovarian carcinomas (HGSOC) an aggressive cancer characterized by ubiquitous p53 mutations. Rescued p53 behaves similarly to its wild type counterpart in regulating target genes, reducing cell proliferation and increasing cell death. Intraperitoneal administration decreases tumor proliferation and shrinks xenografts in vivo. Our data show the effectiveness of targeting a specific aggregation defect of p53 and its potential applicability to HGSOCs.
Hereditary breast and ovarian cancer: new genes in confined pathways
Venue: Nature Reviews Cancer

Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary breast and ovarian cancer (HBOC) However, only approximately 25% of cases of HBOC can be ascribed to BRCA1 and BRCA2 mutations. Recently, exome sequencing has uncovered substantial locus heterogeneity among affected families without BRCA1 or BRCA2 mutations. The new pathogenic variants are rare, posing challenges to estimation of risk attribution through patient cohorts. In this Review article, we examine HBOC genes, focusing on their role in genome maintenance, the possibilities for functional testing of putative causal variants and the clinical application of new HBOC genes in cancer risk management and treatment decision making.
From Moving Cube to Urban Interactive Structures A case study

When thinking about the future vision of a city, having in mind recent development in digital technologies and digital design tools we are inclined to expect new building structures which incorporate this technology to better help us manage the complexity of life, and to simplify our daily lives and tasks. The idea behind this research paper lies in design of such structures, which could be put inside an urban context and engage in creating a built environment that can add more to the quality of life. For us Interactive architecture is architecture that is responsive, flexible, changing, always moving and adapting to the needs of today. The world is becoming more dynamic, society is constantly changing and the new needs it develops need to be accommodated. As a result architecture has to follow. Spaces have to become more adaptive, responsive and nature concerned, while having the ability for metamorphosis, flexibility and interactivity. Taken as a starting point of this idea is a specific module from graduation project in 2014 "The Unexpected city" where it was possible to test out first ideas about interactive and flexible objects in an urban environment.
Integracion vertical en el sector colombiano de la salud

Este articulo presenta una revision de la literatura relacionada con la integracion vertical en sistemas de salud, con un enfasis especial en el sector colombiano de la salud. Empezamos introduciendo algunos conceptos generales acerca de la integracion vertical, y presentamos algunas de sus ventajas y desventajas tradicionales. Luego, nos enfocamos en las consecuencias de la integracion vertical en el sector de la salud, tomando como referencia la experiencia de Estados Unidos. A continuacion, describimos el sistema de salud colombiano y algunos cambios de la regulacion de la integracion vertical. Finalmente, proveemos algunas recomendaciones de politica publica relacionada con esta regulacion. En particular, recomendamos un cambio desde un enfoque regulatorio hacia un modelo de supervision.