nils-herrmann/clean_scirepeval huggingface dataset:
Efficient identity based leveled fully homomorphic encryption from RLWE
Venue: Secur. Commun. Networks

Based on the learning with errors over rings (RLWE) assumption, a leveled fully homomorphic encryption (FHE) by the approximate eigenvector method under the same public key is proposed, which security can be reduced to the shortest vector problem on ideal lattices in the worst case. And the leveled FHE under different public keys is realized by the secret key switching without dimension reduction. Combine the public key of leveled FHE with the identity, we bring forward an efficient identity based leveled FHE scheme from the RLWE assumption. The security analysis shows that our identity based leveled FHE scheme is selective ID secure against chosen plaintext attacks in the random oracle model. And the efficiency analysis and simulation results show that the proposed identity based leveled FHE scheme is much more efficient than Gentry's and Wang's identity based cryptosystems based on the learning with errors assumption.
Preparation of graphene nano sheet bonded PDA/MOF microcapsules with immobilized glucose oxidase as a mimetic multi enzyme system for electrochemical sensing of glucose.
Venue: Journal of materials chemistry. B

A novel amperometric biosensor for glucose detection was fabricated based on a mimetic multi enzyme system by combing mimetic enzymes (metal organic frameworks, MOFs) and glucose oxidase (GOx) The microcapsule constructed with polydopamine (PDA) and ZIF 8 using CaCO3 templates could be utilized not only to provide the biocompatible and non toxic microenvironment to immobilize GOx, but also as an efficient mimetic enzyme because of the peroxidase like properties of ZIF 8. The graphene nano sheets (rGO) were bonded to the PDA/ZIF 8 microcapsules to accelerate the electron transfer between the microcapsule and the electrode, and the resulted PDA/ZIF 8@rGO showed excellent electro catalytic activity towards H2O2. The mimetic multi enzyme system was fabricated when GOx was immobilized in the as prepared microcapsule, and the developed GOx/PDA/ZIF 8@rGO/GCE biosensor exhibited extraordinary electro detection performance for glucose with two wide linear ranges from 1 mM to 1.2 mM and 1.2 mM to 3.6 mM, and the limit of detection was 0.333 mM (S/N 3) Moreover, the good selectivity for glucose and satisfactory detection results in real samples of the prepared biosensor were also demonstrated.
De novo construction of multi enzyme system for one pot deracemization of (R,S) 1 phenyl 1,2 ethanediol by stereoinversion of (S) enantiomer to the corresponding counterpart

Deracemization via oxidoreductive stereoinversion is one of the most attractive methods for the preparation of enantiomerically pure compounds. However, available enzymatic system is yet limited for efficiently catalyzing deracemization to produce optically pure alcohol in certain configuration. Through evaluation of available stereoselective oxidoreductases on activity, selectivity, and cofactor dependency, the suitable candidates were obtained to construct the enzymatic deracemization system involving cofactor self recycling. For deracemizing (R,S) 1 phenyl 1,2 ethanediol (PED) to (R) PED, a facile one pot system was established by combination of two stereoselective oxidoreductases, the stereospecific carbonyl reductase 1 (SCR1) and the ketoreductase (KRD) To rebalance the activities and catalytic functions of different enzymes involved in the multi enzyme system, the reaction conditions of SCR1 catalyzed oxidation and KRD mediated reduction were optimized, respectively. Consequently, the deracemization system involving cofactor self recycling was built to produce (R) PED with the optical purity of 95.50%e.e. and the yield of 91.62% from the corresponding racemate (1 g L 1) under the optimal reaction conditions including activity ratio of SCR1/KRD 1:4 (SCR1 10 U mL 1 and KRD 40 U mL 1) molar ratio of NADP+/NADPH 3:1, 30 degC, and pH 7.0. Therefore, the developed strategy would be useful to construct the multi enzyme deracemization system based on systematic evaluation of enzyme features.
Immobilization of a multi enzyme system for L amino acids production

Four enzymes were immobilized for the production of optically pure natural and non natural L amino acids via the 'Double Racemase Hydantoinase Process' Immobilization constitutes an empirical process, and for each enzyme we tested 11 carriers with different functional groups; epoxide, EC EP, EC HFA, IB 150 and IB 350, carboxylic acid IB C435, quaternary ammonium IB A161, IB A171 and IB A369, aromatic group IB S861, and hydroxyl group IB S60S and IB S60P. RESULTS Each protein showed preference for binding on one or several supports: D,L hydantoinase/IB 350, hydantoin racemase/EC EP, L carbamoylase/EC EP and carbamoyl racemase/IB A161. The process was optimized for each enzyme by modifying temperature, pH and ionic strength. For the enzymatic cascade, it was demonstrated that it was essential to use supports having homogeneous characteristics. The product of the first reaction is the substrate of the next one, and so on. Free mass diffusion from one enzyme to the other is crucial to avoid retention on the support and to maintain the protein substrate interaction constant.  It was proved that support size, weight and hydrophobicity must be homogeneous to avoid the formation of separate layers of the matrix selected. For this reason, the support IB 350 was used for the four enzymes, even though it may not be the most efficient one for some of them.
Discovering similar Twitter accounts using semantics
Venue: Eng. Appl. Artif. Intell.

On daily basis, millions of Twitter accounts post a vast number of tweets including numerous Twitter entities (mentions, replies, hashtags, photos, URLs) Many of these entities are used in common by many accounts. The more common entities are found in the messages of two different accounts, the more similar, in terms of content or interest, they tend to be. Towards this direction, we introduce a methodology for discovering and suggesting similar Twitter accounts, based entirely on their disseminated content in terms of Twitter entities used. The methodology is based exclusively on semantic representation protocols and related technologies. An ontological schema is also described towards the semantification of the Twitter accounts and their entities.
Thematic labeling of Twitter accounts using DBpedia properties
Venue: 2016 11th International Workshop on Semantic and Social Media Adaptation and Personalization (SMAP)

In this paper, we propose an iterative algorithm towards the automatic labeling of Twitter accounts in respect to thematic categories derived from DBpedia properties. We describe the rationale behind the selection of these thematic categories, and discuss their evaluation assessment. Finally, we propose and analyze two generic and adaptable methodologies for discovering the necessary linked data resources for further enhancing the thematic description of Twitter accounts.
SABRE: WIMP modulation detection in the northern and southern hemisphere

Measuring an annual modulation in a direct Dark Matter detection experiment is not only a proof of the existence of WIMPs but can also tell us more about their interaction with standard matter and maybe even their density and velocity in the halo. Such a modulation has been measured by the DAMA/LIBRA experiment in NaI(Tl) crystals. However, the interpretation as WIMP signal is controversial due to contradicting results by other experiments. The SABRE experiment aims to shed light on this controversy by detecting the annual modulation in the same target material as DAMA with twin detectors at LNGS in Italy and at SUPL in Australia. The two locations in the northern and southern hemisphere allow to verify if other seasonal effects or the site have an influence on the measurement, thus reducing systematic effects. This paper will give an overview on the experimental design, the current status of the proof of principle phase mainly devoted to high purity crystal growing, and an outlook on future plans.
Design of a cost effective wind/photovoltaic/hydrogen energy system for supplying a desalination unit by a heuristic approach

The techno economic assessment, optimization, and sizing of grid independent renewable energy systems affects not only the likelihood of deployment but also their reliability to supply potable water and electricity where needed. Despite many investigations on hybrid renewable energy systems (photovoltaic/wind) the reverse osmosis desalination unit powered by solar and wind electricity production systems with hydrogen energy storage, and effects of integrating water desalination alongside meeting load demand, is rarely found. In this paper, a hybrid photovoltaic/wind/hydrogen/reverse osmosis desalination system is modeled and designed for increasing the fresh water availability and to meet the load demand to a stand alone region in Iran. The configuration of the proposed hybrid system is optimally determined with respect to two optimization criteria, the life cycle cost of the economic evaluation and the loss of power supply probability concept for the reliability. For this aim, an efficient metaheuristic technique based on artificial bee swarm optimization is used. From the results it is seen that at a maximum loss of power supply probability set to 0 10% the photovoltaic/hydrogen/reverse osmosis desalination is the most cost effective energy system and photovoltaic/wind/hydrogen/reverse osmosis desalination and wind/hydrogen/reverse osmosis desalination systems are in the other ranks.
POEM is a cost effective procedure: cost utility analysis of endoscopic and surgical treatment options in the management of achalasia
Venue: Surgical Endoscopy

BackgroundAchalasia is a rare motility disorder of the esophagus. Treatment is palliative with the goal of symptom remission and slowing the progression of the disease. Treatment options include per oral endoscopic myotomy (POEM) laparoscopic Heller myotomy (LM) and endoscopic treatments such as pneumatic dilation (PD) and botulinum toxin type A injections (BI) We evaluate the economics and cost effectiveness of treating achalasia.MethodsWe performed cost analysis for POEM, LM, PD and BI at our institution from 2011 to 2015. Cost of LM was set to 1, and other procedures are presented as percentage change. Cost effectiveness was calculated based on cost, number of interventions required for optimal results for dilations and injections and efficacy reported in the current literature. Incremental cost effectiveness ratio was calculated by a cost utility analysis using quality adjusted life year gained, defined as a symptom free year in a patient with achalasia.ResultsAverage number of interventions required was 2.3 dilations or two injections for efficacies of 80 and 61 respectively. POEM cost 1.058 times the cost of LM, and PD and BI cost 0.559 and 0.448 times the cost of LM. Annual cost per cure over a period of 4 years for POEM, and LM were consistently equivalent, trending the same as PD although this has a lower initial cost. The cost per cure of BI remains stable over 3 years and then doubles.ConclusionThe cost effectiveness of POEM and LM is equivalent. Myotomy, either surgical or endoscopic, is more cost effective than BI due to high failure rates of the economical intervention. When treatment is being considered BI should be utilized in patients with less than 2 year life expectancy. Pneumatic dilations are cost effective and are an acceptable approach to treatment of achalasia, although myotomy has a lower relapse rate and is cost effective compared to PD after 2 years.
Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model.
Venue: Life sciences

Exercise training (ET) has a cardioprotective effect and can alter the molecular response to myocardial infarction (MI) The Neuregulin 1 (NRG1)/ErbB signaling plays a critical role in cardiac repair and regeneration in the failing heart. We sought to investigate whether ET following MI could activate the NRG1/ErbB signaling and promote cardiac repair and regeneration.  Male Sprague Dawley rats were used to establish the MI model. Exercise trained animals were subjected to four weeks of exercise (16m/min, 50min/d, 5d/wk) following the surgery. AG1478 was used as an inhibitor of ErbB (1mg/kg body weight, administered i.v. every other day during the process of training) NRG1/ErbB signaling activation, cardiomyocyte (CM) proliferation and apoptosis were evaluated.  In the exercise trained rats, NRG1 expression was up regulated and ErbB/PI3K/Akt signaling was activated compared with the MI group. In addition, ET preserved heart function accompanied with increased numbers of BrdU( CMs, PCNA( CMs and c kit( cells, and reduced apoptosis level in the MI rats. In contrast, blocking ErbB signaling by AG1478 attenuated the ET induced cardiac repair and regeneration.  ET up regulates NRG1 expression and activates ErbB2, ErbB4 and PI3K/Akt signal transduction to promote cardiac repair through endogenous regeneration. Activation of ErbB may be an underlying mechanism for the ET induced cardiac repair and regeneration following MI.
Clinical benefit of high sensitivity cardiac troponin I in the detection of exercise induced myocardial ischemia.
Venue: American heart journal

A pilot study using a novel high sensitivity cardiac troponin I (hs cTnI) assay suggested that cTnI might be released into blood during exercise induced myocardial ischemia. We investigated the potential clinical value of this signal.  We included 819 patients with suspected exercise induced myocardial ischemia referred for rest/bicycle myocardial perfusion single photon emission computed tomography. The treating cardiologist used all available clinical information to quantify clinical judgment regarding the presence of myocardial ischemia using a visual analog scale twice: prior and after stress testing. High sensitivity cTnI measurements were obtained before, immediately after peak stress, and 2 hours after stress testing in a blinded manner. Myocardial ischemia was adjudicated using perfusion single photon emission computed tomography and coronary angiography findings.  Exercise induced myocardial ischemia was detected in 278 (34% patients. High sensitivity cTnI levels were significantly higher at all time points in patients with myocardial ischemia as compared with those without (P .001 for all) Combining clinical judgment prior exercise testing with baseline hs cTnI levels increased diagnostic accuracy as quantified by the area under the receiver operating characteristics curve (AUC) from 0.672 to 0.757 (P .001) Combining clinical judgment after exercise testing (AUC 0.704) with baseline or poststress hs cTnI levels also increased the diagnostic accuracy (AUC 0.761 0.771, P .001 for all) In contrast, exercise induced changes in hs cTnI during exercise did not seem useful, as they were small and similar in patients with or without myocardial ischemia.  High sensitivity cTnI concentrations at rest and after exercise, but not its exercise induced changes, provide substantial incremental value to clinical judgment including exercise electrocardiography regarding the presence of myocardial ischemia.
Modeling spatiotemporal variabilities of length at age growth characteristics for slow growing subarctic populations of Lake Whitefish, using hierarchical Bayesian statistics

Though Lake Whitefish are ecologically, culturally and economically important to aboriginal communities in the Northwest Territories, Canada, growth characteristics of the fish populations have not received extensive interpretations, resulting in a lack of quantitative information to support fisheries management efforts in subarctic great lake systems. The overall objective of this study is to investigate spatiotemporal variations of growth characteristics of Lake Whitefish populations in Great Slave Lake (GSL) from 1972 2009. Using hierarchical Bayesian statistics, we structured four candidate growth models: generalized (GGM) logistic (LGM) Gompertz (PGM) and von Bertalanffy (VBM) with four parameterization scenarios combining all possible options of varying or constant L and K. In terms of deviance information criterion (DIC) and multimodel inference (MMI) the plausibility of the candidate models was evaluated to select the best combinations of growth models and the parameter scenarios. The GGM with varying L and K best delineated the fish growth characteristics in almost all areas of GSL, while the fish growth model parameterized with constant L and varying K performed best in the shallow western basin. The VGM where L and K were varied partially described fish growth in the shallow waters. Applying the MMI based growth analysis, we found that smaller and slower growing fish were mainly distributed in deep waters, while larger and faster growing fish inhabited shallow waters. These spatiotemporal variations of fish growth characteristics have been attributed to the presence of coupled impacts derived from both climate driven and anthropogenic events.
Improving age depth models of fluvio lacustrine deposits using sedimentary proxies for accumulation rates

Lacustrine fills, including those of oxbow lakes in river floodplains, often hold valuable sedimentary and biological proxy records of palaeo environmental change. Precise dating of accumulated sediments at levels throughout these records is crucial for interpretation and correlation of (proxy) data existing within the fills. Typically, dates are gathered from multiple sampled levels and their results are combined in age depth models to estimate the ages of events identified between the datings. In this paper, a method of age depth modelling is presented that varies the vertical accumulation rate of the lake fill based on continuous sedimentary data. In between Bayesian calibrated radiocarbon dates, this produces a modified non linear age depth relation based on sedimentology rather than linear or spline interpolation.The method is showcased on a core of an infilled palaeomeander at the floodplain edge of the river Rhine near Rheinberg (Germany) The sequence spans from ~4.7 to 2.9 ka cal BP and consists of 5.5 m of laminated lacustrine, organo clastic mud, covered by ~1 m of peaty clay. Four radiocarbon dates provide direct dating control, mapping and dating in the wider surroundings provide additional control. The laminated, organo clastic facies of the oxbow fill contains a record of nearby fluvial geomorphological activity, including meander reconfiguration events and passage of rare large floods, recognized as fluctuations in coarseness and amount of allochthonous clastic sediment input. Continuous along core sampling and measurement of loss on ignition (LOI) provided a fast way of expressing the variation in clastic sedimentation influx from the nearby river versus autochthonous organic deposition derived from biogenic production in the lake itself. This low cost sedimentary proxy data feeds into the age depth modelling. The sedimentology modelled age depth relation (re)produces the distinct lithological boundaries in the fill as marked changes in sedimentation rate. Especially the organo clastic muddy facies subdivides in centennial intervals of relative faster and slower accumulation. For such intervals, sedimentation rates are produced that deviate 10 20% from that in simpler stepped linear age models. For irregularly laminated muddy intervals of the oxbow fill from which meaningful sampling for radiocarbon dating is more difficult than from peaty or slowly accumulating organic lake sediments supplementing spotty radiocarbon sampling with continuous sedimentary proxy data creates more realistic age depth modelling results.
'I thought if I marry the prophet I would not die' The significance of religious affiliation on marriage, HIV testing, and reproductive health practices among young married women in Zimbabwe
Venue: SAHARA J journal of Social Aspects of HIV/AIDS Research Alliance

This study examines the association between religious affiliation and reasons for marriage, perceived church attitudes, and reproductive health seeking behaviors, including HIV testing, among young women in eastern rural Zimbabwe. The sample comprised women (N 35) who had married by 2012 while participating in a larger randomized controlled trial (RCT) to test the effects of school support on HIV related risk. The RCT sample was identified in 2007 as all female sixth graders in 25 rural eastern Zimbabwe primary schools whose parents, one or both, had died (N 328) In our previous RCT analyses, we found that participants who affiliated with an Apostolic church were more than four times more likely to marry than those from non Apostolic churches and that control group participants were twice as likely to marry as those in the intervention group. Other studies had found that marriage greatly increased the odds of HIV infection among adolescent women. Given the link between Apostolic affiliation and marriage, we conducted semi structured interviews to explore type of marriage, reasons for marrying, church affiliation and attitudes, family planning, HIV testing, schooling, and family life. We were interested in differences, as perceived by our sample of young married women congregants, among Apostolic sects and other denominations in their attitudes about marriage and health seeking behaviors. We were also interested in the influence of church affiliation on intervention participants' decision to marry, since they had comprehensive school support and education is highly valued in Zimbabwe, but costly and often out of financial reach. Interviews were conducted from October 2012 through November 2013; data were analyzed using a general inductive approach. We found that pressure or perceived deception for coitus or marriage was reported only by intervention participants affiliated with Apostolic denominations. Other reasons for marriage were similar between Apostolic and non Apostolic adherents, as well as intervention and control conditions. All participants believed HIV testing was important, but while all non Apostolic denominations encouraged HIV testing and clinic/hospital care, there was considerable heterogeneity in attitudes among Apostolics, with ultraconservative denominations most likely to proscribe non religious health care. We conclude that some, but not all, Apostolic affiliated women are afforded discretion in their health seeking behaviors. Since HIV screening and treatment depend on access to clinic/hospital care, continued public health efforts to engage Apostolic leaders is needed, along with monitoring of progress in access and outcomes.