Wide field and highly sensitive angiography based on optical coherence tomography with akinetic swept source

Wide field vascular visualization in bulk tissue that is of uneven surface is challenging due to the relatively short ranging distance and significant sensitivity fall off for most current optical coherence tomography angiography (OCTA) systems. We report a long ranging and ultra wide field OCTA (UW OCTA) system based on an akinetic swept laser. The narrow instantaneous linewidth of the swept source with its high phase stability, combined with high speed detection in the system enable us to achieve long ranging (up to 46 mm) and almost negligible system sensitivity fall off. To illustrate these advantages, we compare the basic system performances between conventional spectral domain OCTA and UW OCTA systems and their functional imaging of microvascular networks in living tissues. In addition, we show that the UW OCTA is capable of different depth ranging of cerebral blood flow within entire brain in mice, and providing unprecedented blood perfusion map of human finger in vivo. We believe that the UW OCTA system has promises to augment the existing clinical practice and explore new biomedical applications for OCT imaging. (c)2016 Optical Society of America OCIS codes: (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170.0110) Imaging systems; (140.3600) Lasers, tunable; (170.2655) Functional monitoring and imaging. References and links 1. R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, "Three dimensional optical angiography," Opt. Express 15(7) 4083 4097 (2007) 2. T. E. de Carlo, A. Romano, N. K. Waheed, and J. S. Duker, "A review of optical coherence tomography angiography (OCTA)"  (2015) 3. R. K. Wang, L. An, S. Saunders, and D. J. Wilson, "Optical microangiography provides depth resolved images of directional ocular blood perfusion in posterior eye segment," J. Biomed. Opt. 15, 020502 (2010) 4. A. Mariampillai, B. A. Standish, E. H. Moriyama, M. Khurana, N. R. Munce, M. K. K. Leung, J. Jiang, A. 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