nils-herrmann/clean_scirepeval huggingface dataset:
IGF IR signaling in epithelial to mesenchymal transition and targeting IGF IR therapy: overview and new insights
Venue: Molecular Cancer

The insulin like growth factor I (IGF I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical studies, targeting of the insulin like growth factor I receptor (IGF IR) showed promising anti tumor effects. Unfortunately, high expectations for anti IGF IR therapy encountered challenge and disappointment in numerous clinical trials. This review summarizes the regulation of EMT by IGF I/IGF IR signaling pathway and drug resistance mechanisms of targeting IGF IR therapy. Most importantly, we address several factors in the regulation of IGF I/IGF IR associated EMT progression that may be potential predictive biomarkers in targeted therapy.
Intelligent Seven DoF Robot With Dynamic Obstacle Avoidance and 3 D Object Recognition for Industrial Cyber Physical Systems in Manufacturing Automation
Venue: Proceedings of the IEEE

In this paper, a service oriented multiagent system (SoMAS) for the control and analysis of the cyber physical system (CPS) in manufacturing automation utilizing a noncontact dynamic obstacle avoidance seven DoF robot arm is presented. The interfaces of the services which the robot arm subsystem should provide to fully exploit its capability are identified. Specifically, the services of moving, object recognition, object fetching, and safety of human robot interaction are considered as the fundamental functionalities that the robot arm should provide. The way to evaluate the quality of services (QoS) for the robot arm subsystem is also explained. To build such a robot arm subsystem, the system architecture is proposed. Also, implementation for the subsystem which includes: 3 D model based object recognition, grasp database for object fetching, and online noncontact obstacle avoidance for the safety of human robot interaction is provided. The experimental results demonstrate that the capability of 3 D model based object recognition, object fetching, and dynamic collision avoidance are successfully implemented.
Attachment and Academic Classroom Behavior: Self Efficacy and Procrastination as Moderators on the Influence of Attachment on Academic Success

Attachment, self efficacy, and procrastination were measured in 161 college students enrolled in an Introductory Psychology class. Class grades and overall academic records were also obtained. Students who had higher levels of attachment anxiety had lower final grades in the class, higher levels of procrastination, and lower self efficacy. Students with higher levels of attachment avoidance had lower grades within the class and a lower overall Grade Point Average (GPA) Regression analysis showed that self efficacy moderated the relationship between attachment and class grade as well as overall GPA. Procrastination also moderated the relationship between both attachment anxiety and GPA and attachment avoidance and GPA.
Developing specialist CBT supervision training in Scotland using blended learning: challenges and opportunities
Venue: The Cognitive Behaviour Therapist

NHS Education for Scotland (NES) has developed a suite of training to address the learning and development needs of supervisors of psychological therapies in the National Health Service (NHS) in Scotland and to support quality of evidence based practice in psychological therapies, in light of the recent expansion in this area of healthcare. In parallel with the structure of the recently developed supervisory competency frameworks, an initial training package addressing generic (cross modality) supervision competences was supplemented by the development of a training package to meet the specific needs of supervisors of CBT: NES Specialist Supervision Training in CBT (NESSST CBT) A blended learning package was developed, in light of the emerging evidence around the effectiveness of e learning, to produce a flexible and learner centred training package. This paper describes the development, delivery and planned evaluation methods of NESSST CBT. Lessons learned during implementation are outlined, along with key challenges regarding the future of supervision training in Scotland and the UK.
NaviLight: investigating ambient light displays for turn by turn navigation in cars
Venue: MobileHCI

Car navigation systems typically combine multiple output modalities; for example, GPS based navigation aids show a real time map, or feature spoken prompts indicating upcoming maneuvers. However, the drawback of graphical navigation displays is that drivers have to explicitly glance at them, which can distract from a situation on the road. To decrease driver distraction while driving with a navigation system, we explore the use of ambient light as a navigation aid in the car, in order to shift navigation aids to the periphery of human attention. We investigated this by conducting studies in a driving simulator, where we found that drivers spent significantly less time glancing at the ambient light navigation aid than on a GUI navigation display. Moreover, ambient light based navigation was perceived to be easy to use and understand, and preferred over traditional GUI navigation displays. We discuss the implications of these outcomes on automotive personal navigation devices.
Passive Communication with Ambient Light
Venue: CoNEXT

In this work, we propose a new communication system for illuminated areas, indoors and outdoors. Light sources in our environments such as light bulbs or even the sun are our signal emitters, but we do not modulate data at the light source. We instead propose that the environment itself modulates the {ambient} light signals: if mobile elements `wear' patterns consisting of distinctive reflecting surfaces, single photodiode could decode the disturbed light signals to read passive information. Achieving this vision requires a deep understanding of a new type of communication channel. Many parameters can affect the performance of passive communication based on visible light: the size of reflective surfaces, the surrounding light intensity, the speed of mobile objects, the field of view of the receiver, to name a few. In this paper, we present our vision for a passive communication channel with visible light, the design challenges and the evaluation of an outdoor application where our receiver decodes information from a car moving at 18 km/h.
Validacion psicometrica en espanol de la version corta brasilena del cuestionario Primary Care Assessment Tools: usuarios para la evaluacion de la orientacion de los sistemas de salud hacia la atencion primaria
Venue: Atencion Primaria

Resumen Objetivo Validar en espanol la version corta brasilena del PCAT para pacientes adultos. Diseno Analisis de datos secundarios, de la encuesta realizada para validar la version extensa del cuestionario PCAT. Emplazamiento Ciudad de Cordoba, Argentina. Atencion primaria. Participantes El 46% de esta muestra estuvo integrada por madres y padres, cuyos hijos estaban cursando educacion media en 3 institutos de la Ciudad de Cordoba, y el 54% restante, por beneficiarios adultos de la Obra Social de la Universidad Nacional de Cordoba. Mediciones principales Correlacion de Pearson, comparando version extensa y corta, indicadores de buen ajuste al analisis factorial confirmatorio, valores de fiabilidad compuesta, varianza media extractada y alpha de Cronbach, para evaluar validez de constructo y fiabilidad de la version corta. Resultados Los valores de correlacion de Pearson entre esta version corta y la version extensa fueron altos 0,818 (p 0,001) lo que implica una muy buena validez de criterio. Los indicadores de buen ajuste globales al AFC fueron buenos. El valor de fiabilidad compuesta fue bueno (0,802) pero bajo el de varianza media extractada: 0,3306, dado que 3 variables presentaron cargas factoriales debiles. El alpha de Cronbach fue adecuado (0,85) Conclusiones La version corta del PCAT usuarios desarrollada en Brasil evidencio un aceptable rendimiento psicometrico en espanol, como herramienta de evaluacion rapida, en un estudio comparativo con la version extensa.
Artificial Bone via Bone Tissue Engineering: Current Scenario and Challenges
Venue: Tissue Engineering and Regenerative Medicine

Bone provides mechanical support, and flexibility to the body as a structural frame work along with mineral storage, homeostasis, and blood pH regulation. The repair and/or replacement of injured or defective bone with healthy bone or bone substitute is a critical problem in orthopedic treatment. Recent advances in tissue engineering have shown promising results in developing bone material capable of substituting the conventional autogenic or allogenic bone transplants. In the present review, we have discussed natural and synthetic scaffold materials such as metal and metal alloys, ceramics, polymers, etc. which are widely being used along with their cellular counterparts such as stem cells in bone tissue engineering with their pros and cons.
Naturalistic Outcomes of Evidence Based Therapies for Borderline Personality Disorder at a Medical University Clinic.
Venue: American journal of psychotherapy

Dialectical behavior therapy (DBT) and dynamic deconstructive psychotherapy (DDP) are listed in the National Registry of Evidence Based Programs and Practices based on their performances in randomized controlled trials. However, little is known about their effectiveness in real world settings. In the present study, the authors observed the naturalistic outcomes of 68 clients with borderline personality disorder (BPD) who were treated at a medical university clinic by experienced therapists using either comprehensive DBT (n 25) or DDP (n 27) with 16 clients treated with unstructured psychotherapy serving as a control. We found both DBT and DDP achieved significant reductions in symptoms of BPD, depression, and disability by 12 months of treatment, and showed effect sizes consistent with controlled trials. However, attrition from DBT was high and DDP obtained better outcomes than DBT (d .53) Larger effectiveness studies are needed to replicate these findings, delineate common and unique treatment processes, and determine therapist and patient characteristics predicting positive outcomes.
Comparing Apache Solr and Elasticsearch search servers

The paper presents a comparative analysis of the leading two platforms for developing information retrieval systems, Apache Solr and Elasticsearch. We briefly examine other similar solutions, but focus on the previously mentioned solutions as they provide greater functionality with better performance. Our goal was to examine both systems, including what they offer and how they are used. We examine expert opinions on both systems, as well as concrete use cases. After that we make a comparative analysis focusing on many aspects, from usability to working at scale. Finally we conclude which system works better for which use case.
A comparative study of elasticsearch and CouchDB document oriented databases
Venue: 2016 International Conference on Inventive Computation Technologies (ICICT)

With the advent of large complex datasets, NOSQL databases have gained immense popularity for their efficiency to handle such datasets in comparison to relational databases. There are a number of NOSQL data stores for e.g. Mongo DB, Apache Couch DB etc. Operations in these data stores are executed quickly. In this paper we aim to get familiar with 2 most popular NoSQL databases: Elasticsearch and Apache CouchDB. This paper also aims to analyze the performance of Elasticsearch and CouchDB on image data sets. This analysis is based on the results carried out by instantiate, read, update and delete operations on both document oriented stores and thus justifying how CouchDB is more efficient than Elasticsearch during insertion, updation and deletion operations but during selection operation Elasticsearch performs much better than CouchDB. The implementation has been done on LINUX platform.
Associations of Cognitive Function Scores with Carbon Dioxide, Ventilation, and Volatile Organic Compound Exposures in Office Workers: A Controlled Exposure Study of Green and Conventional Office Environments
Venue: Environmental health perspectives

The indoor built environment plays a critical role in our overall well being because of both the amount of time we spend indoors ~90% and the ability of buildings to positively or negatively influence our health. The advent of sustainable design or green building strategies reinvigorated questions regarding the specific factors in buildings that lead to optimized conditions for health and productivity.  We simulated indoor environmental quality (IEQ) conditions in "Green" and "Conventional" buildings and evaluated the impacts on an objective measure of human performance: higher order cognitive function.  Twenty four participants spent 6 full work days (0900 1700 hours) in an environmentally controlled office space, blinded to test conditions. On different days, they were exposed to IEQ conditions representative of Conventional [high concentrations of volatile organic compounds (VOCs) and Green (low concentrations of VOCs) office buildings in the United States. Additional conditions simulated a Green building with a high outdoor air ventilation rate (labeled Green+ and artificially elevated carbon dioxide (CO2) levels independent of ventilation.  On average, cognitive scores were 61% higher on the Green building day and 101% higher on the two Green+ building days than on the Conventional building day (p 0.0001) VOCs and CO2 were independently associated with cognitive scores.  Cognitive function scores were significantly better under Green+ building conditions than in the Conventional building conditions for all nine functional domains. These findings have wide ranging implications because this study was designed to reflect conditions that are commonly encountered every day in many indoor environments.  Associations of cognitive function scores with carbon dioxide, ventilation, and volatile organic compound exposures in office workers: a controlled exposure study of green and conventional office environments. Environ Health Perspect 124:805 812; http:/dx.doi.org/10.1289/ehp.1510037
Volatile Organic Compound Emissions from Humans Indoors.
Venue: Environmental science technology

Research on the sources of indoor airborne chemicals has traditionally focused on outdoor air, building materials, furnishings, and activities such as smoking, cooking, and cleaning. Relatively little research has examined the direct role of occupant emissions, even though this source clearly contributes to indoor volatile organic compounds (VOCs) and influences indoor chemistry. In this work, we quantify occupant related gaseous VOC emissions in a university classroom using a proton transfer reaction time of flight mass spectrometer. Time resolved concentrations of VOCs in room air and supply air were measured continuously during occupied and unoccupied periods. The emission factor for each human emitted VOC was determined by dividing the occupant associated source rate by the corresponding occupancy. Among the most abundant species detected were compounds associated with personal care products. Also prominent were human metabolic emissions, such as isoprene, methanol, acetone, and acetic acid. Additional sources included human skin oil oxidation by ozone, producing compounds such as 4 oxopentanal (4 OPA) and 6 methyl 5 hepten 2 one (6 MHO) By mass, human emitted VOCs were the dominant source (57% during occupied periods in a well ventilated classroom, with ventilation supply air the second most important (35% and indoor nonoccupant emissions the least (8% The total occupant associated VOC emission factor was 6.3 mg h 1 per person.
Promoting sustainability in the mussel industry: mussel shell recycling to fight fluoride pollution

Taking into account a background situation where some industrial activities greatly influence fluoride pollution, while other industries generate by products that could be effective as fluoride bio sorbents, and bearing in mind sustainability and environmental concern, batch type experiments were performed to study fluoride sorption/desorption on individual (un amended) and mussel shell amended soils and materials. Specifically, the research focused on a forest soil, a vineyard soil, pyritic material, granitic material, and ground mussel shell, as well as on both soils and the pyritic and granitic materials amended with mussel shell. The main findings of the research indicate that the shell amendment clearly increased fluoride sorption in the pyritic material (reaching more than 90% showing no effect as regards fluoride desorption from this material. The amendment caused a slight increase in fluoride sorption on forest soil, as well as a slight decrease in fluoride desorption from it. The un amended vineyard soil and the un amended granitic material had lower fluoride retention capacity than the forest soil and pyritic material, and it did not change after amending with mussel shell. The mussel shell by itself showed the lowest fluoride retention potential among the tested materials. As a conclusion, and focusing on applicability, these results can be useful to program the correct use of mussel shell amendment on soils and even on degraded environments with the aim of increasing fluoride retention or removal, thus decreasing risk of environmental pollution due to excessive fluoride concentrations in solid and/or liquid media, also facilitating recycling, sustainability and cleaner production in the mussel shell industry.
[Thyroid gland pathology in children population exposed to the combination of iodine deficiency and fluoride pollution of environment]
Venue: Gigiena i sanitariia

The article presents results of study of the impact of iodine deficiency and technogenic fluoride on the state of the thyroid gland in children. On the example of two districts of the city of Bratsk there were executed dynamic investigations (2002 and 2012) including the estimation of the pollution of ambient air and soil by fluorine compounds, levels of iodine intake by the body, the clinical examination of children aged from 5 to 7 years d and interviewing of their parents. In the course of the medical examination there were executed: physical examination by the pediatrician, endocrinologist, ultrasound examination of the thyroid gland, the determination both of serum hormone content by radioimmunoassay and urinary excretion offluorine and iodine. Concentrations of hydrogen fluoride and a solidfluorides in ambient air led to the accumulation offluoride ion in the soil. The iodine entering with drinking water and food, was established to provide only 37.5 50% of the daily requirement of iodine. Increased fluoride ion content in urine and milk teeth in children is associated with the concentrations of the fluorine containing pollutants in the ambient air and soil. The fluoride pollution against the background of the natural iodine deficiency was established to increase the frequency of functional and morphological disorders of the thyroid gland in children.
Harsh Parenting, Deviant Peers, Adolescent Risky Behavior: Understanding the Meditational Effect of Attitudes and Intentions.
Venue: Journal of research on adolescence the official journal of the Society for Research on Adolescence

Although research supports the influence of parents and peers on adolescent risky behavior, less is known about mechanisms proposed to explain this relation. This study examined the influence of adolescent attitudes and intentions about such behaviors. Prospective, longitudinal data came from rural youth who participated throughout adolescence (n= 451) Observed harsh parenting and relationship with deviant peers was assessed in early adolescence, attitudes and intentions were measured during middle adolescence, and risky behavior was assessed in late adolescence. Results indicated that parenting and deviant peers was related to engagement in tobacco use, alcohol use, and risky sexual behaviors. Moreover, attitudes and intentions mediated this relationship even after parent use and adolescent early involvement in these behaviors were taken into account.
Mosaic structure of Mycobacterium bovis BCG genomes as a representation of phage sequences' mobility
Venue: BMC Genomics

BackgroundThe control of genome stability is relevant for the worldwide BCG vaccine preventing the acute forms of childhood tuberculosis. BCG sub strains whole genome comparative analysis and revealing the triggers of sub strains transition were the purpose of our investigation.ResultsWhole genome sequencing of three BCG Russia seed lots (1963, 1982, 2006 years) confirmed the stability of vaccine sub strain genome.Comparative analysis of three Mycobacteruim bovis and nine M. bovis BCG genomes shown that differences between "early" and "late" sub strains BCG genomes were associated with specific prophage profiles. Several prophages common to all BCG genomes included ORFs which were homologues to Caudovirales. Surprisingly very different prophage profiles characterized BCG Tice and BCG Montreal genomes. These prophages contained ORFs which were homologues to Herpesviruses. Phylogeny of strains cohort based on genome maps restriction analysis and whole genomes sequence data were in agreement with prophage profiles. Pair wise alignment of unique BCG Tice and BCG Montreal prophage sequences and BCG Russia 368 genome demonstrated only similarity of fragmetary sequences that suggested the contribution of prophages in genome mosaic structure formation.ConclusionsControl of the extended sequences is important for genome with mosaic structure. Prophage search tools are effective instruments in this analysis.
Acaricide resistance of Rhipicephalus microplus ticks in Benin

After the introduction of the invasive cattle tick Rhipicephalus microplus in West Africa in the last decade, farmers encounter ticks resistance to the use of acaricides in different region in Benin. In order to evaluate the level of resistance, an in vitro study was performed on five samples of R. (Boophilus) microplus collected from five farms in four of the eight agro ecological zone of Benin. The districts concerned with the study in the agro ecological zone were Houeyogbe (Kpinnou) Zangnanado (Samiondji) Tchaourou (Okpara) Gogounou (Fana) and Bassila (Manigri) A toxicological test, the Larval Packet Test (LPT) was performed in the laboratory of Biotechnology Research Unit of the Animal Production and Health (URBPSA) at the Polytechnic School of University of Abomey Calavi in Benin with the susceptible, Rhipicephalus geigyi strain from Hounde in Burkina Faso. Three (3) acaricides commonly used by farmers in Benin to control ticks were evaluated: alpha cypermethrin, deltamethrin and amitraz. The results showed that the resistance ratio at 50% (RR50 95% CI) for the whole experiment varies from 1.96 to 338.5. Based on RR50 and RR90 values, only the population of Samiondji's state farm was susceptible to the alpha cypermethrin with a resistance ratio RR50 1.64 (95% CI: 0.2 to 12.6 all the other resistance tests conducted on moderate or high resistance Bassila and Kpinnou appear to host the most resistant samples. Moreover, a certain high variability of dose response relationship has been noticed with amitraz on the base of the higher slope of the related curves.  Resistance ratio, distribution, Rhipicephalus microplus, acaricide, larval packet test (LPT) Benin