nils-herrmann/clean_scirepeval huggingface dataset:
Evidence based treatments for youths with severely dysregulated mood: a qualitative systematic review of trials for SMD and DMDD
Venue: European Child Adolescent Psychiatry

The aim of this literature review was to examine the evidence for psychotherapeutic and pharmacological treatments in subjects with severely dysregulated mood and to identify potential areas for improvements in research designs. A literature search was conducted using several databases for published (PubMed, PsycINFO) and ongoing (clinical trial registries) studies conducted in youths who met NIMH's criteria for Severe Mood Dysregulation (SMD) or the DSM 5 diagnosis of Disruptive Mood Dysregulation Disorder (DMDD) Eight completed studies were identified: three randomized trials, four open pilot studies and one case report. Seven ongoing studies were found in trial registries. The available evidence suggests potential efficacy of psychotherapies which have previously been developed for internalizing and externalizing disorders. The two main pharmacological strategies tested are, first, a monotherapy of psychostimulant or atypical antipsychotic such as risperidone, already used in the treatment of severe irritability in youths with developmental disorders; and second, the use of a serotonergic antidepressant as an add on therapy in youths treated with psychostimulant. Ongoing studies will further clarify the effectiveness of psychotherapeutic interventions for DMDD individuals and whether they should be given alone or in conjunction with other treatments. The short duration of the trials for a chronic disorder, the low number of studies, the lack of placebo or active comparator arm, and restrictive inclusion criteria in most of the controlled trials dramatically limit the interpretation of the results. Finally, future research should be conducted across multiple sites, with standardized procedures to measure DMDD symptoms reduction, and include a run in period to limit placebo effect.
Further investigations into the single metal deposition (SMD II) technique for the detection of latent fingermarks.
Venue: Forensic science international

Single metal deposition (SMD II) a recently proposed method for the development of latent fingermarks, was investigated by systematically altering aspects of the procedure to assess their effect on the level of development and contrast achieved. Gold nanoparticle size, temperature of the deposition solution bath, and orbital shaking during detection were shown to affect the levels of development and contrast obtained. Gold nanoparticles of diameter 15 21nm were found to be most effective for satisfactory visualisation of latent fingermarks, while solutions that were applied at room temperature were found to adequately balance the ratio between the contrast of the fingermark ridge detail and the level of background staining achieved. Finally, optimum levels of development and contrast were obtained through constant agitation of both solution baths at approximately 50RPM throughout the submersion time. SMD II was also tested on a large variety of substrate types and shown to be effective on a range of porous, non porous, and semi porous surfaces; however, the detection quality can be significantly influenced by the substrate nature. This resulted in the production of dark grey, white, or gold coloured fingermarks on different surfaces, as well as reversed detection on certain types of plastic, similarly seen through the use of vacuum metal deposition.
El Nino and climate change contributing factors in the dispersal of Zika virus in the Americas?
Venue: The Lancet

In their letter, Isaac I Bogoch and colleagues Jan 23, p 335) anticipated the international spread of Zika virus from Brazil through air traffi c. Permissive climatic conditions for Aedes mosquitoes might have contributed to the explosive spread of Zika virus in Brazil. In fact, the 2015 El Nino caused exceptional climatic conditions in northeastern South America during winter and spring in the southern hemisphere. According to the US National Oceanic and Atmospheric Administration, the temperatures over north and eastern South America were "record warmest" accompanied by a severe drought, throughout the second half of 2015. These extreme conditions might also be a manifestation of climate change that have contributed to the rapid dispersal of the Zika virus. A striking overlap emerges when regions with extreme climatic conditions in one month are juxtaposed to the geographic distribution of Zika virus in the subsequent month (appendix) Temperature is known to have a role in adult vector survival, viral replication, and infective periods. Elevated temperatures (within a temperature envelope) can expand the geographic vector range, decrease the extrinsic incubation period of the pathogen, and increase the female mosquito biting rate. Although precipitation provides essential habitat for larvae during the aquatic stages of the Aedes lifecycle, drought can indirectly expand the vector's range. In several locations (including northeastern Brazil) the risk of range expansion of Aedes aegypti is correlated with an increase in water storage in household containers during a persistent regional drought. Thus, the unique climatic conditions created during this severe El Nino event should be considered contributing factors in the dispersal of Zika virus in the Americas and should also be considered as the virus continues to spread.
Zika virus: A call to action for physicians in the era of climate change
Venue: Preventive medicine reports

In February 2016, the World Health Organization declared the mosquito borne Zika virus to be a "public health emergency of international concern" as the disease linked to thousands of birth defects in Brazil spreads rapidly. The distribution of the Aedes mosquitos has drastically increased over the past few decades, which have been the hottest decades on Earth in more than 1000 years based on climate proxy measures. Although a combination of factors explains the current Zika virus outbreak, it's highly likely that the changes in the climate contribute to the spread of Aedes vector carrying the Zika virus, the pathogen causing serious birth defects. Physicians, both individually and collectively, as trusted and educated members of society have critical roles to play. In addition to clinical management and prevention of Zika, physicians should communicate about the health benefits of addressing climate change in straightforward evidence based language to their local communities and policymakers, and make clear their support for policies mitigating climate change.
Risk factors for lung cancer worldwide
Venue: European Respiratory Journal

Lung cancer is the most frequent malignant neoplasm in most countries, and the main cancer related cause of mortality worldwide in both sexes combined. The geographic and temporal patterns of lung cancer incidence, as well as lung cancer mortality, on a population level are chiefly determined by tobacco consumption, the main aetiological factor in lung carcinogenesis. Other factors such as genetic susceptibility, poor diet, occupational exposures and air pollution may act independently or in concert with tobacco smoking in shaping the descriptive epidemiology of lung cancer. Moreover, novel approaches in the classification of lung cancer based on molecular techniques have started to bring new insights to its aetiology, in particular among nonsmokers. Despite the success in delineation of tobacco smoking as the major risk factor for lung cancer, this highly preventable disease remains among the most common and most lethal cancers globally. Future preventive efforts and research need to focus on non cigarette tobacco smoking products, as well as better understanding of risk factors underlying lung carcinogenesis in never smokers. Tobacco smoking is the major determinant of lung cancer risk; genetics, occupation, pollution, poor diet also contribute http:/ow.ly/4mRbUQ
Risk factors for postoperative anxiety and depression after surgical treatment for lung cancer+
Venue: European journal of cardio thoracic surgery official journal of the European Association for Cardio thoracic Surgery

Psychological distress associated with cancer treatment is an emerging issue in the management of cancer patients. The aim of this study was to identify the prevalence of postoperative anxiety and depression after surgical treatment for lung cancer, and to assess the risk factors associated with these phenomena.  Patients who underwent curative surgical resection for primary lung cancer were included in this study. Patients with complex treatment histories (recurrent or metastatic lung cancer or neoadjuvant treatment) and those taking psychiatric medication were excluded. We prospectively evaluated the degrees of pre and postoperative anxiety and depression using a Hospital Anxiety Depression Scale questionnaire. The relationships between clinical and patient factors and anxiety and depression after surgical treatment for lung cancer were assessed.  A total of 278 patients were enrolled. The mean age was 62 years. Thoracoscopic resection was performed in 246 patients (89% The prevalence rates of preoperative anxiety and depression were 8% (n 22) and 12% (n 32) and changed to 9% (n 26) and 19% (n 54) postoperatively (P 0.37 and <0.001, respectively) Gender, age, marital status, advanced clinical stage, alcohol abuse, smoking status, length of hospital stay, pulmonary function and preoperative comorbidities were not associated with postoperative anxiety and depression. Multivariate analysis revealed that thoracotomy was a risk factor for postoperative anxiety after adjusting for preoperative anxiety (odds ratio [OR] 4.5, P 0.002) Thoracotomy (OR 3.4, P 0.009) postoperative dyspnoea (OR 4.8, P 0.001) severe pain (OR 3.9, P 0.001) and diabetes mellitus (OR 3.0, P 0.012) were identified as risk factors for postoperative depression after adjusting for preoperative depression. Twenty four patients were referred to mental health professionals and provided with supportive psychotherapy or pharmacological intervention. Of these, 14 patients (56% were diagnosed with an adjustment disorder.  Postoperative psychological distress and, in particular, depression increased after surgical treatment for lung cancer. Postoperative anxiety and depression were aggravated by residual symptoms after surgery. Careful psychological evaluation and appropriate management are required to improve patients' quality of life after lung cancer surgery.
Agile business process development: why, how and when applying Nonaka's theory of knowledge transformation to business process development
Venue: Inf. Syst. E Bus. Manag.

The traditional way of business process development is via creating a detailed model of a business process in question, acquiring an IT system to support it, and then implementing it in the organizational practice. Acquiring a system can be done via designing and manufacturing it by the business itself, or via commissioning it to somebody else. Alternatively, a generic system can be bought and configured according to the business process model created. The traditional approach has a number of risks that become visible only during the latest phase of introducing the system in the organizational practice, e.g. when it becomes clear that the system does not fit the business and/or people who work in it. These risks could be mitigated by using an agile approach to the development of business processes. In agile approach: (a) the phases of process modeling, IT system design, and manufacturing are merged into one, and (b) instead of using one big cycle, a series of smaller development cycles is used. The paper discusses what is needed to implement the agile approach, and in which business situations the agile approach is the most appropriate. Examples of tools to support agile development are presented and analyzed. The results presented in the paper have been achieved based on the knowledge transformation perspective along the lines suggested by Nonaka in SECI model. The modification of this model has been used to understand the risks and requirements connected to a particular process development strategy.
Establishing of knowledge based framework for situational awareness using Nonaka's and Endsley's models
Venue: 2016 International Conference on Information and Communication Technology (ICICTM)

Up to this moment, there is no knowledge based framework with situational awareness using the combination of two models: Nonaka and Endsley. These models can assist our research in terms of collecting and transforming appropriate tacit knowledge into enhancing the existing explicit knowledge. The existing explicit knowledge can be found from training module (doctrines) or any relevant documents. However, tacit knowledge is not easily extracted due to being stored implicitly into the mind of the experienced staff. Therefore, this paper explains the structured way on how to collect appropriate tacit knowledge from the experienced staff.
Investigating Knowledge Management Status among Faculty Members of Kerman University of Medical Sciences based on the Nonaka Model in 2015
Venue: Electronic physician

Education and research are two major functions of universities, which require proper and systematic exploitation of available knowledge and information. Therefore, it is necessary to investigate the knowledge management status in an education system by considering the function of faculty members in creation and dissemination of knowledge. This study was conducted to investigate the knowledge management status among faculty members of the Kerman University of Medical Sciences based on the Nonaka and Takeuchi models in 2015.  This was a descriptive analytical and cross sectional study. It was conducted on 165 faculty members at the Kerman University of Medical Sciences, who were selected from seven faculties as weighted using a random stratified sampling method. The Nonaka and Takeuchi knowledge management questionnaire consists of 26 questions in four dimensions of socialization, externalization, internalization, and combination. Scoring of questions was conducted using the five point Likert scale. To analyze data, independent t test, one way ANOVA, Pearson correlation coefficients, and the Kruskal Wallis test were employed.  The four dimensions in the Nonaka and Takeuchi model are based on optimal indicators (3.5) dimensions of combination, and externalization with an average of 3.3 were found in higher ranks and internalization and socialization had averages of 3.1 and 3. According to the findings of this study, the average knowledge management among faculty members of the Kerman University of Medical Sciences was estimated to be 3.1, with a bit difference compared to the average. According to the results of t tests, there was no significant relationship between gender and various dimensions of knowledge management (p>0.05) The findings of Kruskal Wallis showed that there is no significant relationship between variables of age, academic rank, and type of faculty with regard to dimensions of knowledge management (p>0.05) In addition, according to the results of Pearson tests, there is no significant relation between employment history and dimensions of knowledge management (p>0.05)  Considering the function and importance of knowledge management in education and research organizations including universities, it is recommended to pay comprehensive attention to establishment of knowledge management and knowledge sharing in universities and provide the required background to from research teams and communication networks inside and outside universities.
Thermal evolution of the Hengshan extensional dome in central South China and its tectonic implications: New insights into low angle detachment formation

The Hengshan massif is an exhumed, mid crustal, plutonic metamorphic dome formed during Cretaceous crustal extension in the Jiangnan orogenic belt, central South China. Multiple thermochronometers (mica 40Ar/39Ar, apatite fission track and zircon (U Th)/He) are applied to its footwall along a slip parallel transect to quantify its thermal history and cooling rate, and the slip magnitude, rate, initial geometry and kinematic evolution of the low angle Hengshan detachment fault. Our thermochronological data, in conjunction with previous ages, indicate that (1) footwall rocks cooled from 700 degC to 60 degC in less than 60 Myr (136 80 Ma) at variable rates ranging from 50 degC/Myr to 13 degC/Myr, (2) the Hengshan detachment fault accommodated 8 12 km of total slip at variable slip rates from 0.14 to 1 mm/yr during tectonic exhumation, (3) the footwall has been tilted 26deg 50deg to the east since slip began, indicating that the low angle Hengshan detachment fault initiated at a steep dip and was passively rotated to a more gentle orientation during subsequent normal slip. This study provides compelling evidence supporting that the low angle detachment fault in the extensional dome can be generated by the reactivation and passive rotation of an initially steep reverse fault during normal slip. In addition, our thermochronological data constrain the time of extension in the Hengshan dome between 136 and 80 Ma, which implies that the back arc extension within South China associated with the rollback of the Paleo Pacific slab might have lasted until at least 80 Ma.
New insights into Phanerozoic tectonics of south China: Part 1, polyphase deformation in the Jiuling and Lianyunshan domains of the central Jiangnan Orogen

The central Jiangnan Orogen, genetically formed by the Proterozoic Yangtze Cathaysia collision, presents as a composite structural feature in the Phanerozoic with multiple ductile and brittle fabrics whose geometries, kinematics, and ages are crucial to decipher the tectonic evolution of south China. New structural observations coupled with thermochronological and geochronological studies of these fabrics document four main stages of deformation. The earliest stage in early Paleozoic time (460 420 Ma) corresponds to combined E trending dextral and northwest directed thrust shearing that was variably partitioned in anastomosing high strain zones under greenschist facies conditions ~400 500degC) related to the continued Yangtze Cathaysia convergence externally driven by the suturing of south China with Australia. This event was heterogeneously overprinted by the second stage characterized by ~E oriented folding in middle Triassic time, geodynamically resulting from the continental collision of south China with Indochina and North China. The third stage was locally developed by northwest and southeast vergent thrusts that truncated ~E oriented folds in the Late Jurassic, due to northwestward subduction of the Paleo Pacific plate. The latest stage involved normal faulting and tectonic unroofing in Cretaceous time, which resulted in basin opening and reset footwall 40Ar/39Ar ages in proximity to the Hengshan detachment fault, associated with roll back of the subducting Paleo Pacific plate.
The centrosome is an actin organizing center
Venue: Nature Cell Biology

Microtubules and actin filaments are the two main cytoskeleton networks supporting intracellular architecture and cell polarity. The centrosome nucleates and anchors microtubules and is therefore considered to be the main microtubule organizing centre. However, recurring, yet unexplained, observations have pointed towards a connection between the centrosome and actin filaments. Here we have used isolated centrosomes to demonstrate that the centrosome can directly promote actin filament assembly. A cloud of centrosome associated actin filaments could be identified in living cells as well. Actin filament nucleation at the centrosome was mediated by the nucleation promoting factor WASH in combination with the Arp2/3 complex. Pericentriolar material 1 (PCM1) seemed to modulate the centrosomal actin network by regulating Arp2/3 complex and WASH recruitment to the centrosome. Hence, our results reveal an additional facet of the centrosome as an intracellular organizer and provide mechanistic insights into how the centrosome can function as an actin filament organizing centre.
53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration
Venue: The Journal of cell biology

Meitinger et al. perform a genome wide CRISPR/Cas9 screen for centrinone resistance and identify a 53BP1 USP28 module as critical for communicating mitotic challenges to the p53 circuit and TRIM37 as an enforcer of the singularity of centrosome assembly.
Periventricular anastomosis in moyamoya disease: detecting fragile collateral vessels with MR angiography.
Venue: Journal of neurosurgery

OBJECT The authors' aim in this paper was to determine whether periventricular anastomosis, a novel term for the abnormal collateral vessels typical of moyamoya disease, is reliably measured with MR angiography and is associated with intracranial hemorrhage.  This cross sectional study sampled consecutive patients with moyamoya disease or moyamoya syndrome at a single institution. Periventricular anastomoses were detected using MR angiography images reformatted as sliding thin slab maximum intensity projection coronal images and were scored according to 3 subtypes: lenticulostriate, thalamic, and choroidal types. The association between periventricular anastomosis and hemorrhagic presentation at onset was evaluated using multivariate analyses.  Of 136 eligible patients, 122 were analyzed. Eighteen (14.8% patients presented with intracranial hemorrhage with neurological symptoms at onset. Intra and interrater agreement for rating of the periventricular anastomosis score was good (kw 0.65 and 0.70, respectively) The prevalence of hemorrhagic presentation increased with the periventricular anastomosis score: 2.8% for Score 0, 8.8% for Score 1, 18.9% for Score 2, and 46.7% for Score 3 (p 0.01 for trend) Univariate analysis revealed that age (p 0.02) and periventricular anastomosis score (p 0.01) were factors tentatively associated with hemorrhagic presentation. The score remained statistically significant after adjustment for age (OR 3.38 [95% CI 1.84 7.00]  The results suggest that periventricular anastomosis detected with MR angiography can be scored with good intra and interrater reliability and is associated with hemorrhagic presentation at onset in moyamoya disease. The clinical utility of periventricular anastomosis as a predictor for hemorrhage should be validated in further prospective studies.
Automatically Detecting the Up To Date Status of ToDo Comments in Java Programs
Venue: ISEC

Easing program comprehension facilitates software maintenance, which consumes a disproportionate amount of resources within software development. Studies have shown that good comments can help in program comprehension. Among the different varieties of comments, TODO comments are used by developers to denote pending tasks. A developer may perform the task mentioned in the TODO comment but may forget to remove it, leading to obsolete comments. Such obsolete comments can hinder comprehension. Detecting such obsolete comments manually is tedious and error prone. Thus, we need a tool to automatically check the status of TODO comments. We present a novel technique to automatically detect the status of a TODO comment. Given a method with a TODO comment, our TODO comment status checker uses information retrieval, linguistics and semantics to check if the comment is up to date. According to experienced programmers who judged our status checker, we achieve good accuracy, precision and recall.