nils-herrmann/clean_scirepeval huggingface dataset:
Selective spider toxins reveal a role for Nav1.1 channel in mechanical pain
Venue: Nature

Voltage gated sodium (Nav) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non specific actions at all Nav channels, but the discovery of selective modulators would facilitate the analysis of individual subtypes of these channels and their contributions to chemical, mechanical, or thermal pain. Here we identify and characterize spider (Heteroscodra maculata) toxins that selectively activate the Nav1.1 subtype, the role of which in nociception and pain has not been elucidated. We use these probes to show that Nav1.1 expressing fibres are modality specific nociceptors: their activation elicits robust pain behaviours without neurogenic inflammation and produces profound hypersensitivity to mechanical, but not thermal, stimuli. In the gut, high threshold mechanosensitive fibres also express Nav1.1 and show enhanced toxin sensitivity in a mouse model of irritable bowel syndrome. Together, these findings establish an unexpected role for Nav1.1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain.
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
Venue: Nature

When integral membrane proteins are visualized in detergents or other artificial systems, an important layer of information is lost regarding lipid interactions and their effects on protein structure. This is especially relevant to proteins for which lipids play both structural and regulatory roles. Here, we demonstrate the power of combining electron cryo microscopy with lipid nanodisc technology to ascertain the structure of the TRPV1 ion channel in a native bilayer environment. Using this approach, we determined the locations of annular and regulatory lipids and showed that specific phospholipid interactions enhance binding of a spider toxin to TRPV1 through formation of a tripartite complex. Furthermore, phosphatidylinositol lipids occupy the binding site for capsaicin and other vanilloid ligands, suggesting a mechanism whereby chemical or thermal stimuli elicit channel activation by promoting release of bioactive lipids from a critical allosteric regulatory site.
Policy Analysis of Integrated Antenatal Care implementation at Public Health Centers in Blitar City

Integrated antenatal care as one of key program in screening maternal and child health services isstarted antenatal to puerperium phase and it is essential to protect complications during both antenatal and postnatalphases. Access to antenatal care (fi rst ANC to fourth ANC) has became providers key strategies in order to decreasemissed opportunities of pregnant women that it can be implicated toward services quality and caused by increasing MMRand IMR in Blitar City. The purpose of this study was to analize of policy implementation for Integrated Antenatal Careservices at Sananwetan, Kepanjen kidul, and Sukorejo Public Health Centers.  A qualitative study with purposivedesign. Method for policy analysis used "a health policy triangle framework" (Walt Gilson, 1994)  Lack of therole of policy actors in fi elds to bridge among integrated antenatal care services program, midwives, lab analyst andprovider. Integrated Antenatal care Services are concerned with physical examinations conducted by Midwives and areconcerned with laboratorium test both routine and medical indications conducted by laboratory analyst. Lack of technicaltraining for midwives and lab analyst.  Inter Sectoral partnership for policy actors in implementing integratedantenatal care of Health Centers were lack and ranning partially. Lack of availability of laboratory facilities and USG toexam pregnant womens. Local Government Regulation regarding general services retributions are concerned routine lab and medical indications examinations is not yet for the poor peoples.  The masive role of policy actorsin Blitar City through inter sectoral partnership involving policy review, monitoring, and evaluation of integrated antenatalcare for health centers are sustainable. Budgetting in APBD and other sources to enhance laboratorium facilities andUSG at three Health Centers based on types of laboratory and medical devices. Integrated antenatal care strengtheningthrough technicals training are especially midwives and laborium analysts in developing midwives in obstetrics and medicalexamination competencies. We need a limited revision of regulation clauses. It is clauses of routine lab examination andmedical indications free for every poor womens that conduct lab examinations.
Analisis kebijakan implementasi antenatal care terpadu puskesmas di kota Blitar

Integrated antenatal care as one of key program in screening maternal and child health services is started antenatal to puerperium phase and it is essential to protect complications during both antenatal and postnatal phases. Access to antenatal care (fi rst ANC to fourth ANC) has became providers key strategies in order to decrease missed opportunities of pregnant women that it can be implicated toward services quality and caused by increasing MMR and IMR in Blitar City. The purpose of this study was to analize of policy implementation for Integrated Antenatal Care services at Sananwetan, Kepanjen kidul, and Sukorejo Public Health Centers.  A qualitative study with purposive design. Method for policy analysis used "a health policy triangle framework" (Walt Gilson, 1994)  Lack of the role of policy actors in fi elds to bridge among integrated antenatal care services program, midwives, lab analyst and provider. Integrated Antenatal care Services are concerned with physical examinations conducted by Midwives and are concerned with laboratorium test both routine and medical indications conducted by laboratory analyst. Lack of technical training for midwives and lab analyst.  Inter Sectoral partnership for policy actors in implementing integrated antenatal care of Health Centers were lack and ranning partially. Lack of availability of laboratory facilities and USG to exam pregnant womens. Local Government Regulation regarding general services retributions are concerned routine lab Puslitbang Humaniora dan Manajemen Kesehatan, Badan Litbang Kesehatan, Jl. Indrapura 17 Surabaya,  nauval0817@yahoo.
Container and Microservice Driven Design for Cloud Infrastructure DevOps
Venue: 2016 IEEE International Conference on Cloud Engineering (IC2E)

Emerging container technologies, such as Docker, offer unprecedented agility in developing and running applications in cloud environment especially when combined with a microservice style architecture. However, it is often difficult to use containers to manage the cloud infrastructure, without sacrificing many benefits container offers. This paper identifies the key challenges that impede realizing the full promise of containerizing infrastructure services. Using OpenStack as a case study, we explore solutions to these challenges. Specifically, we redesign OpenStack deployment architecture to enable dynamic service registration and discovery, explore different ways to manage service state in containers, and enable containers to access the host kernel and devices. We quantify the efficiency of the container based microservice style DevOps compared to the VM based approach, and study the scalability of the stateless and stateful containerized components. We also discuss limitations in our current design, and highlight open research problems that, if solved, can lead to wider adoption of containers in cloud infrastructure management.
CLIMB (the Cloud Infrastructure for Microbial Bioinformatics) an online resource for the medical microbiology community
Venue: Microbial genomics

The increasing availability and decreasing cost of high throughput sequencing has transformed academic medical microbiology, delivering an explosion in available genomes while also driving advances in bioinformatics. However, many microbiologists are unable to exploit the resulting large genomics datasets because they do not have access to relevant computational resources and to an appropriate bioinformatics infrastructure. Here, we present the Cloud Infrastructure for Microbial Bioinformatics (CLIMB) facility, a shared computing infrastructure that has been designed from the ground up to provide an environment where microbiologists can share and reuse methods and data.
Magic Quadrant for Cloud Infrastructure as a Service Worldwide 03

Cloud computing is a style of computing in which scalable and elastic IT enabled capabilities are delivered as a service using Internet technologies. Cloud infrastructure as a service (IaaS) is a type of cloud computing service; it parallels the infrastructure and data center initiatives of IT. Cloud compute IaaS constitutes the largest segment of this market (the broader IaaS market also includes cloud storage and cloud printing) Only cloud compute IaaS is evaluated in this Magic Quadrant; it does not cover cloud storage providers, platform as a service (PaaS) providers, software as a service (SaaS) providers, cloud services brokerages or any other type of cloud service provider, nor does it cover the hardware and software vendors that may be used to build cloud infrastructure. Furthermore, this Magic Quadrant is not an evaluation of the broad, generalized cloud computing strategies of the companies profiled.
Anomaly detection and identification scheme for VM live migration in cloud infrastructure
Venue: Future Gener. Comput. Syst.

Virtual machines (VM) offer simple and practical mechanisms to address many of the manageability problems of leveraging heterogeneous computing resources. VM live migration is an important feature of virtualization in cloud computing: it allows administrators to transparently tune the performance of the computing infrastructure. However, VM live migration may open the door to security threats. Classic anomaly detection schemes such as Local Outlier Factors (LOF) fail in detecting anomalies in the process of VM live migration. To tackle such critical security issues, we propose an adaptive scheme that mines data from the cloud infrastructure in order to detect abnormal statistics when VMs are migrated to new hosts. In our scheme, we extend classic Local Outlier Factors (LOF) approach by defining novel dimension reasoning (DR) rules as DR LOF to figure out the possible sources of anomalies. We also incorporate Symbolic Aggregate ApproXimation (SAX) to enable timing information exploration that LOF ignores. In addition, we implement our scheme with an adaptive procedure to reduce chances of performance instability. Compared with LOF that fails in detecting anomalies in the process of VM live migration, our scheme is able not only to detect anomalies but also to identify their possible sources, giving cloud computing operators important clues to pinpoint and clear the anomalies. Our scheme further outperforms other classic clustering tools in WEKA (Waikato Environment for Knowledge Analysis) with higher detection rates and lower false alarm rate. Our scheme would serve as a novel anomaly detection tool to improve security framework in VM management for cloud computing. We extend Local Outlier Factors to detect anomalies in time series and adapt to smooth environmental changes.We propose Dimension Reasoning LOF (DR LOF) that can point out the "most anomalous" dimension of the performance profile. DR LOF provides clues for administrators to pinpoint and clear the anomalies.We incorporate DR LOF and Symbolic Aggregate ApproXimation (SAX) measurement as a scheme to detect and identify the anomalies in the progress of VM live migration.In experiments, we deploy a typical computing application on small scale clusters and evaluate our anomaly detection and identification scheme by imposing two kinds of common anomalies onto VMs.
Hydraulic Control Systems

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Survey on Recent Advances in Networked Control Systems
Venue: IEEE Transactions on Industrial Informatics

Networked control systems (NCSs) are systems whose control loops are closed through communication networks such that both control signals and feedback signals can be exchanged among system components (sensors, controllers, actuators, and so on) NCSs have a broad range of applications in areas such as industrial control and signal processing. This survey provides an overview on the theoretical development of NCSs. In depth analysis and discussion is made on sampled data control, networked control, and event triggered control. More specifically, existing research methods on NCSs are summarized. Furthermore, as an active research topic, network based filtering is reviewed briefly. Finally, some challenging problems are presented to direct the future research.
Tutorial on platform for optical topography analysis tools
Venue: Neurophotonics

Optical topography/functional near infrared spectroscopy (OT/fNIRS) is a functional imaging technique that noninvasively measures cerebral hemoglobin concentration changes caused by neural activities. The fNIRS method has been extensively implemented to understand the brain activity in many applications, such as neurodisorder diagnosis and treatment, cognitive psychology, and psychiatric status evaluation. To assist users in analyzing fNIRS data with various application purposes, we developed a software called platform for optical topography analysis tools (POTATo) We explain how to handle and analyze fNIRS data in the POTATo package and systematically describe domain preparation, temporal preprocessing, functional signal extraction, statistical analysis, and data/result visualization for a practical example of working memory tasks. This example is expected to give clear insight in analyzing data using POTATo. The results specifically show the activated dorsolateral prefrontal cortex is consistent with previous studies. This emphasizes analysis robustness, which is required for validating decent preprocessing and functional signal interpretation. POTATo also provides a self developed plug in feature allowing users to create their own functions and incorporate them with established POTATo functions. With this feature, we continuously encourage users to improve fNIRS analysis methods. We also address the complications and resolving opportunities in signal analysis.
Modern Classical Economics and Reality. A Spectral Analysis of the Theory of Value and Distribution, by Theodore Mariolis and Lefteris Tsoulfidis (Tokyo: Springer Japan, 2016, 242 pp.

The idea of natural prices is one of the oldest and most important concepts in political economy. Natural prices were used by the Physiocrats but only got fully constructed by the classical political economists and Marx. In more recent times, they were further developed by Piero Sraffa and several political economists inspired by his work. Modern Classical Economics and Reality by Theodore Mariolis and Lefteris Tsoulfidis constitute an important contribution within the latter tradition.
Learning, innovation, increasing returns and resource creation: Luigi Pasinetti's 'original sin' of, and call for a post classical, economics

We draw on the seminal contribution to economics by Luigi Pasinetti, respond to his call to reverse what he saw as the 'original sin' of classical economists exacerbated by neoclassical economists, namely the assumption of non increasing returns to scale, and move towards building a post classical economics. We outline the contours of a post classical framework that draws on key themes and contributions from Pasinetti on learning, technical progress, increasing returns, resource creation, trade and catching up, and contributions from within and without economics that are in line with, lend support to and challenge it. We advocate the pressing need and opportune timing for a concerted effort to revitalise ideas from the once vibrant 'Cambridge School' of economics and help develop a fresh, more pluralist and inclusive post classical economics that cuts across divides and opens up opportunities for a less 'dismal science'
Militares desplegados en misiones internacionales: percepcion del estres y sintomas asociados

RESUMEN Introduccion: Los despliegues militares son una de las experiencias profesionales mas exigentes a las que se puede enfrentar un militar profesional. Se diseno un estudio con el objeto de analizar la evolucion del estres percibido y de sintomatologia asociada a la salud mental a una muestra de militares espanoles desplegados durante un periodo de seis meses en Afganistan.  Para ello se realizo un diseno prospectivo en el que 935 militares respondieron al CEP y a la prueba SCL 90R en tres momentos temporales del despliegue (primer mes, tercer mes y ultimo mes) Resultados: Los resultados muestran un aumento del estres percibido a la llegada a zona de operaciones que se mantiene estable a lo largo del despliegue. Respecto a la salud mental se produce un aumento de todos los marcadores de salud mental que se reduce al final de la mision salvo en los casos de Hostilidad y Somatizacion. Respecto a la relacion entre estres percibido y salud mental, se encontro que los sujetos que perciben un mayor estres durante el despliegue desarrollaron un malestar psicologico generalizado en todos los marcadores generales y especificos.  Atendiendo a los resultados podemos concluir que la poblacion militar tiene una percepcion subjetiva del estres significativamente inferior a la poblacion general. El participar en una mision internacional conlleva un aumento del estres percibido, permaneciendo este constante durante todo el despliegue. El nivel de estres percibido esta asociado a un mayor malestar psicologico.
LA SOMATIZACION: DESDE UNA MIRADA PSICOSOCIAL A LOS ESTUDIOS DE LA PERSONALIDAD

La somatizacion se ha convertido en un importante problema de salud mundial, no solo en su especificidad como cuadro clinico sino en el acompanamiento de otros padecimientos medicos o psiquiatricos. El sintoma somatico aparece irreductible al tratamiento medico habitual, y en muchas ocasiones los pacientes que lo padecen no realizan una demanda de ayuda psicologica. En tal sentido se convierte en una problematica de gran interes desde el punto de vista clinico y psicologico. Cuando pensamos a los cuadros de somatizacion desde los distintos modelos teoricos encontramos, constructos que provienen de analisis del proceso salud enfermedad, donde se incluyen elementos referidos a las emociones, el estres, caracteristicas de la personalidad. y supuestos que abordan lo somatico desde el campo de la teoria de la personalidad. Por tales motivos este estudio, se propone una revision de factores de caracter psiquico y social que pueden acompanar dicho sintoma; y al mismo tiempo conduce al establecimiento de una perspectiva desde el campo de estudios de la teoria de la personalidad, para su estudio y tratamiento.
Clustering drug drug interaction networks with energy model layouts: community analysis and drug repurposing
Venue: Scientific reports

Analyzing drug drug interactions may unravel previously unknown drug action patterns, leading to the development of new drug discovery tools. We present a new approach to analyzing drug drug interaction networks, based on clustering and topological community detection techniques that are specific to complex network science. Our methodology uncovers functional drug categories along with the intricate relationships between them. Using modularity based and energy model layout community detection algorithms, we link the network clusters to 9 relevant pharmacological properties. Out of the 1141 drugs from the DrugBank 4.1 database, our extensive literature survey and cross checking with other databases such as Drugs.com, RxList, and DrugBank 4.3 confirm the predicted properties for 85% of the drugs. As such, we argue that network analysis offers a high level grasp on a wide area of pharmacological aspects, indicating possible unaccounted interactions and missing pharmacological properties that can lead to drug repositioning for the 15% drugs which seem to be inconsistent with the predicted property. Also, by using network centralities, we can rank drugs according to their interaction potential for both simple and complex multi pathology therapies. Moreover, our clustering approach can be extended for applications such as analyzing drug target interactions or phenotyping patients in personalized medicine applications.
On design of multi cell thin wall structures for crashworthiness

Multi cell thin wall structures have drawn increasing attention and been widely applied in automotive and aerospace industries for their significant advantages in high energy absorption and lightweight. The number of cells and the topological configurations of the multi cell thin wall structures have a significant effect on the crashworthiness. In order to investigate the effect of the number of cells and the topological configurations of multi cell structures on their crashworthiness characteristics, this paper first sets up the simulation models of multi cell tubes and verifies their accuracy with the quasi static and dynamic impact experiments. Second, it compares the energy absorption characteristics of the multi cell structures with different numbers of cells and topological configurations under dynamic impact condition using finite element analysis (FEA) The results show that the mean crushing force (MFC) and specific energy absorption (SEA) increase with the increase in the number of cells of the multi cell tubes, among which the five cell tube has the best energy absorption characteristics. Third, a parametric study is carried out to investigate the effects of wall thickness and topology configurations on the crashworthiness of five cell tubes. Finally, the multiobjective Non dominated Sorting Genetic Algorithm (NSGA II) is used to further optimize the five cell tube for maximizing specific energy absorption and minimizing peak crushing force (PCF) The optimal five cell tube has excellent crashworthiness and is a potential energy absorber.
Graphene Photodetectors: Large Scale Production of Bismuth Chalcogenide and Graphene Heterostructure and Its Application for Flexible Broadband Photodetector (Adv. Electron. Mater. 5/2016)

In article number 1600077, Bao et al. demonstrate large scale production of Bi2SexTe3 x graphene van deer Waals heterostructures using a solvothermal method. Free standing films produced from this heterostructure show improved electrical, photoelectric and mechanical properties, making their photoresponsive material promising for flexible photodetectors that can operate from visible to near infrared wavelengths.
Targeted Cancer Therapy: pH Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin (Adv. Healthcare Mater. 15/2016)
Venue: Advanced healthcare materials

Targeted theranostic nanoparticles with dual pH and magnetic responsive properties for intracellular delivery are described by B. Herranz Blanco, H. A. Santos, and co workers on page 1904. Using a pH switch nanoprecipitation method in organic free solvents, a polymeric drug conjugate solid nanoparticle containing encapsulated superparamagnetic iron oxide nanoparticles and decorated with a tumor homing peptide, iRGD, are targeted to endothelial and metastatic cancer cells.