Functional imaging of the human brain using a modular fibre less high density diffuse optical tomography system

We present the first three dimensional, functional images of the human brain to be obtained using a fibre less, high density diffuse optical tomography system. Our technology consists of independent, miniaturized, silicone encapsulated DOT modules that can be placed directly on the scalp. Four of these modules were arranged to provide up to 128, dualwavelength measurement channels over a scalp area of approximately 60 x 65 mm 2 Using a series of motor cortex stimulation experiments, we demonstrate that this system can obtain high quality, continuous wave measurements at source detector separations ranging from 14 to 55 mm in adults, in the presence of hair. We identify robust haemodynamic response functions in 5 out of 5 subjects, and present diffuse optical tomography images that depict functional haemodynamic responses that are well localized in all three dimensions at both the individual and group levels. 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