nils-herrmann/clean_scirepeval huggingface dataset:
The Experience, Contributions, and Resilience of Grandparents of Children With Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) affects 1 in 68 children in the United States and has been associated with significant stress on nuclear families. Little is known about the grandparents of these children, however, including their first person, intergenerational experience and potential family contributions. A national, online survey of 1,870 grandparents of grandchildren with ASD revealed that they make significant monetary contributions toward therapeutic needs and frequently play an essential caregiving role. Forty three percent of the grandparents reported making personal sacrifices such as drawing upon their retirement funds or putting off retirement, and 25% of the grandparents moved or combined households to support a grandchild on the autism spectrum. Consistent with resilience theory, the majority of grandparents reported that they were coping fairly or very well in relation to their grandchild's ASD, although they did express significant worry for their adult son's or daughter's well being. However, 12% of grandparents reported that they were coping poorly. Recommendations for future research and public health policy are provided.
Driving CAR T cells forward
Venue: Nature Reviews Clinical Oncology

The engineered expression of chimeric antigen receptors (CARs) on the surface of T cells enables the redirection of T cell specificity. Early clinical trials using CAR T cells for the treatment of patients with cancer showed modest results, but the impressive outcomes of several trials of CD19 targeted CAR T cells in the treatment of patients with B cell malignancies have generated an increased enthusiasm for this approach. Important lessons have been derived from clinical trials of CD19 specific CAR T cells, and ongoing clinical trials are testing CAR designs directed at novel targets involved in haematological and solid malignancies. In this Review, we discuss these trials and present strategies that can increase the antitumour efficacy and safety of CAR T cell therapy. Given the fast moving nature of this field, we only discuss studies with direct translational application currently or soon to be tested in the clinical setting.
A fixed structure topology for wireless networked control systems
Venue: 2016 IEEE 55th Conference on Decision and Control (CDC)

This paper presents the formulation, modelling and design of a fixed structure topology for potential application in wireless networked control systems. The topology consists of a standard plant system, an output feedback controller system, and intermediate transfer and receiving network systems. The paper defines the topology and addresses the modelling of the closed loop control system. It presents a modelling framework to design the controller, the transfer network, and the receiving network systems. Also, the paper discusses a design procedure of using shared network systems for a closed loop control system with multiple plant and controller systems. The design procedures utilize LMI based algorithms and deliver an internally stable closed loop control system whose inputs and outputs satisfy an l2 l performance criterion. The practicality of the design procedures is demonstrated using an illustrative example.
Metabolomics by Gas Chromatography Mass Spectrometry: Combined Targeted and Untargeted Profiling
Venue: Current protocols in molecular biology

Gas chromatography mass spectrometry (GC MS) based metabolomics is ideal for identifying and quantitating small molecule metabolites <650 Da) including small acids, alcohols, hydroxyl acids, amino acids, sugars, fatty acids, sterols, catecholamines, drugs, and toxins, often using chemical derivatization to make these compounds sufficiently volatile for gas chromatography. This unit shows how GC MS based metabolomics allows integration of targeted assays for absolute quantification of specific metabolites with untargeted metabolomics to discover novel compounds. Complemented by database annotations using large spectral libraries and validated standard operating procedures, GC MS can identify and semiquantify over 200 compounds from human body fluids (e.g. plasma, urine, or stool) per study. Deconvolution software enables detection of more than 300 additional unidentified signals that can be annotated through accurate mass instruments with appropriate data processing workflows, similar to untargeted profiling using liquid chromatography mass spectrometry. GC MS is a mature technology that uses not only classic detectors (quadrupole) but also target mass spectrometers (triple quadrupole) and accurate mass instruments (quadrupole time of flight) This unit covers sample preparation from mammalian samples, data acquisition, quality control, and data processing.
Model based requirements specification of real time systems with UML, SysML and MARTE
Venue: Software Systems Modeling

Activities of specification, analysis and design of real time systems (RTS) are highly dependent on an effective understanding of the application domain and on the thorough representation of their basic requirements. Model based approaches using modeling languages such as UML are often applied to contribute to handle complexity of RTS development. However, UML alone does not completely represent important features associated with these systems, such as relationship with hardware elements and an effective representation of timing constraints. This article explores the combined use of UML and its profiles SysML and MARTE for modeling hardware and software requirements of RTS, with application to a case of controlling urban road traffic. The SysML profile alone does not present the representation of temporal, behavioral and performance requirements. The MARTE profile provides key resources to specify non functional requirements for RTS, in addition to a clear description of the various relevant aspects of requirements definition of RTS, as for instance, temporal aspects and constraints. The main objective is to present the combined application of SysML with MARTE stereotypes, which enables the specification of different features of individual software requirements. Thus, in addition to the factors mentioned above, we can say that the proposed approach has an important role to specify RTS at different levels of detail and levels of abstraction.
Comparison of P75NTR positive and negative etcomesenchymal stem cell odontogenic differentiation through epithelial mesenchymal interaction
Venue: Cell proliferation

The aim of this study was to investigate differences of odonto differentiation between P75 neurotrophin receptor (P75 NTR) positive ectomesenchymal stem cells P75+EMSCs) and P75 NTR negative ectomesenchymal stem cells P75 EMSCs) and their underlying mechanisms.
Reconceptualizing Health Lifestyles: The Case of Marriage

Despite mixed evidence, researchers often suggest that married adults tend to live generally healthier lifestyles than their unmarried counterparts. In this chapter, we propose and test a reconceptualization of the health lifestyle that distinguishes between "homebody" risks and "hedonic" risks that may help to make sense of previous findings concerning marriage and health related behavior.  Using data from the 2004 Survey of Adults (n 1,385) we employ ordinary least squares regression to model indices of normative and conventional homebody risks (greater body mass, infrequent exercise, poorer diet, and abstinence from alcohol) and unconventional and potentially dangerous hedonic risks (smoking, heavy drinking, going out to bars, eating out, inadequate sleep, and driving without seatbelts) as a function of marital status.  Our key findings indicate that married adults tend to score higher on homebody risks and lower on hedonic risks than never married adults, net of controls for age, gender, race/ethnicity, citizenship, interview language, education, employment status, household income, and religious involvement.  Research limitations include cross sectional data, restricted indicators of health related behavior, and narrow external validity.  Contrary to previous research, we conclude that the lifestyle of married adults is not uniformly healthy.
Research on the Application of Wechat in College Ideological and Political Education

The only way to implement modern and effective ideological and political education is by the exploring the effectiveness of ideological and political education through various channels. Wechat has become a prevalent social software among the students and has profoundly impact on them, while also it creates tough opportunities and challenges for college ideological and political education. Based on the author' s experience, this paper first analyses the possibility and necessity of Wechat use in college ideological and political education, and then discusses the opportunities and challenges of Wechat use in college ideological and political education, and finally proposes the temporal effectiveness improving of Wechat use in college ideological and political education.
Research on Space time Utility of WeChat Payment

WeChat is a social software developed by Tencent, and in 2013 loaded with WeChat payment function. Since the WeChat red envelopes War fame, WeChat payment will soon become a payment in life by virtue of its convenience and fun, and occupy quickly a certain market based on the social platform of WeChat. Firstly, this paper describes the origin and development of WeChat payment and then discusses the timeliness, spatial temporal connectivity of WeChat payment. Meanwhile, it also points out the insufficient in protecting the interests of consumers and make recommendations, the paper discusses the direction of community development of WeChat payment at the end of the article.
Kinecting Physics: Conceptualization of Motion Through Visualization and Embodiment

The purpose of this work was to share our findings in using the Kinect technology to facilitate the understanding of basic kinematics with middle school science classrooms. This study marks the first three iterations of this design based research that examines the pedagogical potential of using the Kinect technology. To this end, we explored the impact of using the Kinect in conjunction with an SDK Physical Virtual Graphing program on students' understanding of displacement, velocity and acceleration compared to students who conducted more traditional inquiry of the same concepts. Results of this study show that, while there may be some affordances to be gained from integrating this technology, there is a need for a scaffolded approach that helps students to understand the "messiness" of the data collected. Further, meta cognitive activities, such as reflective opportunities, should be integrated into the inquiry experiences in order to scaffold student learning and reinforce concepts being presented. While the Kinect did work to generate large scale visualization and embodied interactions that served as a mechanism for student understanding, this study also suggests that a complementary approach that includes both the use of hands on inquiry and the use of the Kinect sensor, with each activity informing the other, could be a powerful technique for supporting students' learning of kinematics.
A disintegrin and metalloprotease 17 and galectin 9 are important regulators of local 4 1BB activity and disease outcome in rheumatoid arthritis.
Venue: Rheumatology

Co stimulatory T cell cytokines are important in the progression of RA. This study investigates the interplay between 4 1BB, a disintegrin and metalloprotease 17 (ADAM17) and galectin 9 (Gal 9) in RA.  Stimulated mononuclear cells from patients with chronic RA (n 12) were co incubated with tissue inhibitor of metalloproteinase, 4 1BB ligand and Gal 9. Plasma samples were examined for soluble 4 1BB (s4 1BB) in newly diagnosed, treatment naive patients with RA (n 97) The 28 joint DAS with CRP (28DAS CRP) total Sharp score, erosion score and joint space narrowing were used to evaluate treatment outcome serially over a 2 year period.  RA CD4( and CD8( synovial T cells express high levels of 4 1BB. The addition of TNF a to cultured synovial mononuclear cells increased shedding of 4 1BB. 4 1BB ligand only increased TNF a shedding in combination with Gal 9. RNA interference mediated knockdown of ADAM17 or the addition of an ADAM17 inhibitor reduced the 4 1BB shedding. Shedding of 4 1BB was not influenced by Gal 9. Plasma levels of s4 1BB were increased in early RA and correlated with the number of swollen joints at baseline. After 3 months of treatment, the plasma levels of s4 1BB were equal to those of the controls. Baseline plasma levels of s4 1BB were inversely correlated with DAS28 CRP after 2 years of treatment, but not with total Sharp score, erosion score or joint space narrowing.  ADAM17 induces 4 1BB shedding in RA. Gal 9 is pivotal for the function of 4 1BB and induction of TNF a. Furthermore, high plasma levels of s4 1BB were associated with the number of swollen joints, but also with a low DAS28 CRP after 2 years treatment in early RA.
Sorafenib or placebo plus TACE with doxorubicin eluting beads for intermediate stage HCC: The SPACE trial.
Venue: Journal of hepatology

Transarterial chemoembolization with doxorubicin eluting beads (DC Bead(r) DEB TACE) is effective in patients with Barcelona clinic liver cancer stage B hepatocellular carcinoma (HCC) The multikinase inhibitor sorafenib enhances overall survival (OS) and time to tumor progression (TTP) in patients with advanced HCC. This exploratory phase II trial tested the efficacy and safety of DEB TACE plus sorafenib in patients with intermediate stage HCC.  Patients with intermediate stage multinodular HCC without macrovascular invasion (MVI) or extrahepatic spread (EHS) were randomized 1:1 to DEB TACE (150 mg doxorubicin) plus sorafenib 400 mg twice daily or placebo. The primary endpoint was TTP by blinded central review. Secondary endpoints included time to MVI/EHS, OS, overall response rate (ORR) using modified response evaluation criteria in solid tumors, disease control rate (DCR) time to unTACEable progression (TTUP) and safety.  Of 307 patients randomized, 154 received sorafenib and 153 received placebo. Median TTP for subjects receiving sorafenib plus DEB TACE or placebo plus DEB TACE was similar (169 vs. 166 days, respectively; hazard ratio (HR) 0.797, p=0.072) Median time to MVI/EHS (HR 0.621, p=0.076) and OS (HR 0.898, p=0.29) had not been reached. The ORRs for patients in the sorafenib and placebo groups with post baseline scans were 55.9% and 41.3% respectively, and the DCRs were 89.2% and 76.1% respectively. TTUP was lower with sorafenib than with placebo (HR 1.586; 95% confidence intervals, 1.200 2.096; median 95 vs. 224 days) No unexpected adverse events related to sorafenib were observed.  Sorafenib plus DEB TACE was technically feasible, but the combination did not improve TTP in a clinically meaningful manner compared with DEB TACE alone.
SPACE A randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC.
Venue: Radiotherapy and oncology journal of the European Society for Therapeutic Radiology and Oncology

Stereotactic body radiotherapy (SBRT) has been introduced for small lung tumors due to excellent local control and few side effects, even though there are no comparative studies. SPACE (Stereotactic Precision And Conventional radiotherapy Evaluation) is the first randomized phase II trial comparing SBRT and conventional fractionated radiotherapy (3DCRT) METHODS Patients with stage I medically inoperable NSCLC were randomized to receive SBRT to 66Gy in 3 fractions (one week) or 3DCRT to 70Gy (7weeks) Patients were followed to assess efficacy, toxicity and HRQL.  Between 2007 and 2011, 102 patients were randomized. Mean age 74 (57 86) 60% women, the vast majority (92% had COPD or cardiovascular comorbidity. The SBRT arm included more patients with T2 tumors (p=0.02) and male gender (p=0.35) The median follow up was 37months with a 1 2 and 3 year PFS of: SBRT: 76% 53% 42% and 3DCRT: 87% 54% 42% HR=0.85 (95% CI 0.52 1.36) with no difference between the groups and no difference in OS (HR=0.75, 95% CI 0.43 1.30) At the end of the study 70% of SBRT patients had not progressed compared to 59% (3DCRT, p=0.26) Toxicity was low with no grade 5 events. Pneumonitis of any grade was observed in 19% (SBRT) and 34% (3DCRT, p=0.26) and esophagitis in 8% and 30% respectively (p=0.006) HRQL was evaluated with the EORTC QLQ 30 and LC14 module and patients treated with 3DCRT experienced worse dyspnea (p=0.01) chest pain (p=0.02) and cough >10 points difference) INTERPRETATION There was no difference in PFS and OS between SBRT and conventionally treated patients despite an imbalance of prognostic factors. We observed a tendency of an improved disease control rate in the SBRT group and they experienced better HRQL and less toxicity. SBRT is convenient for patients and should be considered standard treatment for patients with inoperable stage I NSCLC.
Efecto del entrenamiento de la fuerza por procesos sobre el equilibrio de los ninos con trastorno del desarrollo de la coordinacion

Recibido: 7 4 2016 Aceptado: 18 7 2016 RESUMEN Introduccion. El equilibrio es uno de los problemas mas importantes de los ninos con trastorno del desarrollo de la coordinacion (TDC) Segun el enfoque por procesos, ademas del entrenamiento de la fuerza, las adaptaciones neuromusculares pueden mejorar el equilibrio. Objetivo. Evaluar los efectos del entrenamiento de la fuerza sobre el equilibrio estatico y dinamico de los ninos con TDC. Metodos y poblacion. En el estudio participaron ninos de 7 a 9 anos de edad de Teheran, y el diseno utilizado fue el de un ensayo controlado aleatorizado. A los sujetos se los separo aleatoriamente en dos grupos: experimental (n= 15) y de referencia (n 15) Los participantes tuvieron 24 sesiones de ejercicio a lo largo de 12 semanas. El grupo experimental realizo el entrenamiento de la fuerza con ejercicios con la banda elastica flexible Thera band(r) mientras que el grupo de referencia hizo los ejercicios de rutina de la clase de educacion fisica. Se midio la fuerza isometrica de los musculos abductores de la cadera y de los flexores plantares con un dinamometro manual, y se utilizo la prueba de destrezas motoras de Bruininks Oseretsky, segunda edicion (BOT 2, por sus siglas en ingles) para medir el equilibrio estatico y dinamico. Los datos se analizaron con pruebas t para muestras independientes y emparejadas. Resultados. El entrenamiento de la fuerza aumento significativamente la fuerza muscular de los ninos con TDC (P 0,001) y mejoro su equilibrio estatico (P 0,05) sin embargo, estos ejercicios no tuvieron un efecto significativo sobre el equilibrio dinamico (P 0,05)  El entrenamiento de la fuerza mejora el equilibrio estatico de los ninos con TDC. No se observo una mejoria del equilibrio dinamico como resultado del entrenamiento de la fuerza en estos ninos. Palabras clave: centrado en procesos, entrenamiento de la resistencia, trastorno del desarrollo de la coordinacion, equilibrio postural.
Design Research of the Electric Gun Mounting Bracket Used for Parking Pre tightening Force Adjusting Nut

For the problem how to fix constant torque electric gun, in parking brake equipped with automatic adjustment system, we propose two solutions, and select a more suitable solution by theoretical analysis. Based on the structure of the handbrake and the electric gun, using 3D modeling software to design the selected solution. At same time, use the finite element analysis to analyze the stress and strain of the leaf spring status. Finally, the solution will be converted to real, and verified that liquid rubber can effectively reduce the spring leaf rivals on the handbrake spring leaf structure by test method, and ultimately proved the feasibility of the design.
Body mass index and the risk of new onset atrial fibrillation in middle aged adults.
Venue: American heart journal

Increased body mass index (BMI) and obesity are associated with increased risk of new onset atrial fibrillation (AF) among middle aged adults.  The objective of the study is to investigate the association between BMI and the risk for new onset AF among middle aged adults.  We investigated 18,290 men and women who were annually screened in a tertiary medical center. Participants were divided at baseline into 3 groups: normal weight (BMI =18 and <25 kg/m(2) n 7,692) overweight (BMI =25 and <30 kg/m(2) n 8,032) and obese (BMI =30 kg/m(2) n 2,566) The primary end point was new onset AF during follow up.  Mean age of study population was 49 11 years, and 73% were men. A total of 288 incident events (1.6% occurred during 6 4 years. Kaplan Meier survival analysis showed that the cumulative probability of AF at 6 years was highest among obese participants, intermediate among overweight participants, and lowest among participants with normal weight (2.1% 1.7% and 0.8% respectively, P .001) Multivariable Cox regression analysis showed that overweight and obesity were independently associated with increased AF risk (hazard ratio 1.54 [P .004] and 2.41 [P .001] respectively) Assessment of BMI change as a time dependent covariate in the multivariable model showed that each 1 kg/m(2) reduction in BMI during follow up was associated with a significant 7% reduction in the risk for the occurrence of a first AF event (hazard ratio 0.93, 95% CI 0.88 0.99, P .019) Consistently, similar analysis showed that each 5 kg weight loss during follow up was independently associated with a significant 12% reduced risk of new onset AF (95% CI 0.81 0.98, P .02) CONCLUSIONS Our findings suggest that overweight and obesity are associated with increased AF risk, whereas weight reduction is independently associated with reduced risk of de novo AF.
An investigation into the particle volume scattering function variability in a cascading reservoir system
Venue: Modeling Earth Systems and Environment

This work analyzed the spectral and spatial distribution of the particle volume scattering function, bp, in a cascading reservoir system. During fieldworks water quality parameters and scattering data were sampled in a predetermined stations. The bp was estimated using the ECO BB9 equipment that measures the volume scattering function, b at 117deg [b(117deg) The estimated bp(117deg) were compared with the remote sensing reflectance, Rrs, and the chlorophyll a (Chl a) concentration, total suspended matter (TSM) concentration and the transparency (measured using a Secch disk) The results showed that in a hypertrophic environment the bp is dominated by the phytoplankton scattering and in an oligotrophic water system, the scattering by a suspended matter dominates. The bp(117deg) variability from a hypertrophic to an oligotrophic aquatic system affects the remote sensing reflectance (Rrs) spectral shape. Due to this, the parametrization of a unique bio optical model to estimate the optically active components in the water will be challenging.
Phenobarbital use and neurological problems in FMR1 premutation carriers.
Venue: Neurotoxicology

Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by a CGG expansion in the FMR1 gene located at Xq27.3. Patients with the premutation in FMR1 present specific clinical problems associated with the number of CGG repeats (55 200 CGG repeats) Premutation carriers have elevated FMR1 mRNA expression levels, which have been associated with neurotoxicity potentially causing neurodevelopmental problems or neurological problems associated with aging. However, cognitive impairments or neurological problems may also be related to increased vulnerability of premutation carriers to neurotoxicants, including phenobarbital. Here we present a study of three sisters with the premutation who were exposed differentially to phenobarbital therapy throughout their lives, allowing us to compare the neurological effects of this drug in these patients.