nils-herrmann/clean_scirepeval huggingface dataset:
Biosimilars in Inflammatory Bowel Disease: Facts and Fears of Extrapolation.
Venue: Clinical gastroenterology and hepatology the official clinical practice journal of the American Gastroenterological Association

Biologic drugs such as infliximab and other anti tumor necrosis factor monoclonal antibodies have transformed the treatment of immune mediated inflammatory conditions such as Crohn's disease and ulcerative colitis (collectively known as inflammatory bowel disease [IBD] However, the complex manufacturing processes involved in producing these drugs mean their use in clinical practice is expensive. Recent or impending expiration of patents for several biologics has led to development of biosimilar versions of these drugs, with the aim of providing substantial cost savings and increased accessibility to treatment. Biosimilars undergo an expedited regulatory process. This involves proving structural, functional, and biological biosimilarity to the reference product (RP) It is also expected that clinical equivalency/comparability will be demonstrated in a clinical trial in one (or more) sensitive population. Once these requirements are fulfilled, extrapolation of biosimilar approval to other indications for which the RP is approved is permitted without the need for further clinical trials, as long as this is scientifically justifiable. However, such justification requires that the mechanism(s) of action of the RP in question should be similar across indications and also comparable between the RP and the biosimilar in the clinically tested population(s) Likewise, the pharmacokinetics, immunogenicity, and safety of the RP should be similar across indications and comparable between the RP and biosimilar in the clinically tested population(s) To date, most anti tumor necrosis factor biosimilars have been tested in trials recruiting patients with rheumatoid arthritis. Concerns have been raised regarding extrapolation of clinical data obtained in rheumatologic populations to IBD indications. In this review, we discuss the issues surrounding indication extrapolation, with a focus on extrapolation to IBD.
Rules and Results for SSL/TLS Nonintrusive Proxy Based on JSON Data
Venue: 2016 6th International Conference on IT Convergence and Security (ICITCS)

The purpose of this study is to implement an adaptive, non intrusive proxy in between a client and SSL/TLS web server using more practical and "middle" approach that can moderate the ongoing and future SSL/TLS sessions. Connection attributes from certificate and SSLProbe results are compared against a set of policies written in JavaScript Object Notation (JSON) The proxy shall handle client session and alerts users when the attributes from the SSL/TLS sites are matched with policy based upon the predefined rules.
Altruism, philantropy and humanism: The conceptual historical aspects of solidarity

This paper presents two main versions of altruism: the filantrophy and the humanism, their most developed historical forms and ways of legitimation. It is shown why private property, market and profite maximization are not inconsinent with the philantrophy and why it is not in accordance with the humanism. One should consider the role of philantrophy in the apology of capitalism.The paper compares two clasical writings: Marx Engels' ,Manifest of the Communist Party" and Andrew Carnegies essay ,The Gospel of Wealth" In addition, it explores historical development, main features and the limitations of solidarity both in humanism and in philantropy in religious and in secular life as well as the types of philantrops and humanists and the contemporary philantrocapitalism in USA and Germany. There are two kinds of the philantropy criticism: (1) Non systemic one, which warns on the different abuses of philantrops, but which doesn't deny the system's foundations, and (2) Systemic one, which does'nt separate the criticism of philantropy from the criticism of capitalism itself. Special attention is dedicated to the usage of symbolic capital in the philantropy and to different doubts about the sincerity of benefaction.There is difference between apstract humanism which only comdemn the inhumanity, on the one side, and the theory of real humanism, as the lever by means of which one should put down exploatation and oppression of human beings. One is able to differentiate between ideological explanations of charity, philantropic and humanistic attempts in the epochal consciousnesses of the different historical ages from the antiquity to neoliberalism. Humanism prevailed during the Cold War in socialism, whereas philantropy has become hegemonic since the collapse of European socialism. Humanism was rooted in critism of the private property, while philantropy serves to promote and the bouergoies values. The conclusion is that the philantrophy relieves misery on the level of distribution, while humanism tries to annihilate the misery on the level of production.
OSOBINE LICNOSTI, NACINI KAZNJAVANJA I SKOLSKA NEDISCIPLINA

This study aimed at testing a mediating role of personality traits in the relationship between different ways of family punishment and inadequate behavior in school. The sample consisted of 479 male and female students of secondary schools in Serbia. Of the total number of respondents, 63.5% were female and the average age of the subjects was 16.76 years. Students' personality characteristics were operationalized through the dimensions of a shortened version of the Big five plus two questionnaire (VP+2) and methods of family punishment were measured with the Scale of punishment in upbringing. The construct of school indiscipline was operationalized as a single score on the scale of school indiscipline. Results suggest existence of a partial mediating role of certain personality traits between the modes of family punishment and school indiscipline. The role of Negative Valence was important in the relationship between all modes of family punishment, except for the physical, and school indiscipline. Aggressiveness had a substantial effect in the relationship between the verbal and separation types of punishment, on the one hand, and school indiscipline, on the other.
Handbook of Energy Harvesting Power Supplies and Applications [Book News]
Venue: IEEE Industrial Electronics Magazine

This book unveils the physical principles of energy harvesting transducers and explains the necessary physics and electronics background leading to the design of energy harvesting power supplies. It explains in detail the available energy harvesting technologies, namely piezoelectric transducers, electrodynamic microgenerators, thermoelectric generators, solar cells, and radio and microwave frequency antennas. The subject coverage ranges from the physics of materials to the electronic engineering at the circuit level while explaining the fundamental relations of power transfer and management required in harvesting energy systems. Due to the intermittency of several sources of ambient energy (light, thermal, mechanic, electromagnetic radiation) the book also includes storage elements. Therefore, it explains and compares storage devices like solidstate thin film lithium batteries, supercapacitors, and reversible fuel cells so the reader can select the most appropriate for a given application. On the electronics side, the book provides a detailed study about dc dc switching regulators, including two fundamental subjects: matching loads and performance efficiency considerations. This last subject, hard to find even in power electronics books, is of paramount importance in the energy harvesting context. The book ends by presenting application fields for energy harvesting power supplies and examples of self powered electronic system blocks for an energy harvesting power supply and the design tradeoffs. This material illustrates the previous subjects while giving quantitative assumptions on environmental energy. The textbook includes prefaces, a table of contents, and an index.
Barriers to and enablers of sustainability integration in the performance management systems of an oil and gas company

The social and environmental impacts of the petroleum industry have serious consequences and call for sustainable solutions and practices. Embedding sustainability into organisations is vital to address these issues, and requires the integration of sustainability into performance management systems. The aim of this paper is to investigate the barriers to, and enablers of, sustainability integration in the performance management systems of an oil and gas company. A qualitative case study has been used to identify the stages and means of integration in the organisation, based on Gond et al.'s (2012) framework depicting the role of control systems in supporting sustainability integration within strategy. The findings revealed that although cognitive, organisational and technical enablers moved integration of sustainability forward in the organisation, certain cognitive barriers considerably affected the attainment of full integration. Institutional pressures provided the impetus for the development of enablers, giving rise to several implications for governments, academics and other parties. The study shows that sustainability integration in performance management systems could lead to better management and control of sustainability performance in organisations. This study provides a more comprehensive approach towards understanding the integration of sustainability in control systems from a socio technical perspective.
A new winding design method for inductors and transformers
Venue: 2016 IEEE 17th Workshop on Control and Modeling for Power Electronics (COMPEL)

In this paper an optimal winding design of inductors and transformers with different winding types is presented. The winding design is implemented both with iterative algorithm and analytical expressions. The optimum thickness formula by Hurley is modified for the use at higher current harmonics and checked with numerical solutions. A design software tool with a graphical user interface is implemented to construct the windings of a medium frequency transformer at minimal achievable winding loss intended for a three phase dual active bridge (DAB3) application. Measurements of the transformers have been performed at a DAB3 platform to compare the calculations of the design tool.
Motivation and Treatment Credibility Predicts Dropout, Treatment Adherence, and Clinical Outcomes in an Internet Based Cognitive Behavioral Relaxation Program: A Randomized Controlled Trial
Venue: Journal of medical Internet research

In previous research, variables such as age, education, treatment credibility, and therapeutic alliance have shown to affect patients' treatment adherence and outcome in Internet based psychotherapy. A more detailed understanding of how such variables are associated with different measures of adherence and clinical outcomes may help in designing more effective online therapy.  The aims of this study were to investigate demographical, psychological, and treatment specific variables that could predict dropout, treatment adherence, and treatment outcomes in a study of online relaxation for mild to moderate stress symptoms.  Participant dropout and attrition as well as data from self report instruments completed before, during, and after the online relaxation program were analyzed. Multiple linear and logistical regression analyses were conducted to predict early dropout, overall attrition, online treatment progress, number of registered relaxation exercises, posttreatment symptom levels, and reliable improvement.  Dropout was significantly predicted by treatment credibility, whereas overall attrition was associated with reporting a focus on immediate consequences and experiencing a low level of intrinsic motivation for the treatment. Treatment progress was predicted by education level and treatment credibility, whereas number of registered relaxation exercises was associated with experiencing intrinsic motivation for the treatment. Posttreatment stress symptoms were positively predicted by feeling external pressure to participate in the treatment and negatively predicted by treatment credibility. Reporting reliable symptom improvement after treatment was predicted by treatment credibility and therapeutic bond.  This study confirmed that treatment credibility and a good working alliance are factors associated with successful Internet based psychotherapy. Further, the study showed that measuring adherence in different ways provides somewhat different results, which underscore the importance of carefully defining treatment adherence in psychotherapy research. Lastly, the results suggest that finding the treatment interesting and engaging may help patients carry through with the intervention and complete prescribed assignments, a result that may help guide the design of future interventions.
Graphine: Programming Graph Parallel Computation of Large Natural Graphs for Multicore Clusters
Venue: IEEE Transactions on Parallel and Distributed Systems

Graph parallel computation has become a crucial component in emerging applications of web search, data analytics and machine learning. In practice, most graphs derived from real world phenomena are very large and scale free. Unfortunately, distributed graph parallel computation of these natural graphs still suffers strong scalability issues on contemporary multicore clusters. To embrace the multicore architecture in distributed graph parallel computation, we propose the framework Graphine, which features (i) A Scatter Combine computation abstraction that is evolved from the traditional vertex centric approach by fusing the paired scatter and gather operations, executed separately on two edge sides, into a one sided scatter. Further coupled with active message mechanism, it potentially reduces intermediate message cost and enables fine grained parallelism on multicore architecture. (ii) An Agent Graph data model, which leverages an idea similar to vertex cut but conceptually splits the remote replica into two agent types of scatter and combiner, resulting in less communication. We implement the Graphine framework and evaluate it using several representative algorithms on six large real world graphs and a series of synthetic graphs with power law degree distributions. We show that Graphine achieves sublinear scalability with the number of cores per node, number of nodes, and graph sizes (up to one billion vertices) and is 2~15 times faster than the state of the art PowerGraph on a cluster of 16 multicore nodes.
Potential Use of Azotobacter and Phosphate Solubilizing Bacteria as Biofertilizer

Biofertilizer contains living microorganisms and promotes growth by increasing the availability of primary nutrient (nitrogen and phosphorus) to the host plant. Biofertilizer also provides nutrients required by the plants and helps to increase the soil quality with natural microorganism (Vessey, 2003) Some of the beneficial microbes used in biofertilizers are N2 fixing bacteria, phosphate solubilizing microbes and mycorrhizae which are able to fix atmospheric nitrogen or solubilize phosphorus in the soil (Subba, 1999) Microorganisms are extensively used as biofertilizers in agricultural practices. The biofertilizers are the live or contain latent cell of beneficial microorganisms, which augment the availability of nutrients to the plants. The beneficial micro organisms are rhizobium, Azotobacters, azospirillum, cyanobacteria, phosphobacteria and mycorrhiza. Among these Azotobacters and phosphate bacteria play major role in the supply of nutrients and in the plant growth promoting activities. These bacteria are International Journal of Current Microbiology and Applied  (2016) pp. 79 90  http:/www.ijcmas.com
Hybrid Digital and Analog Beamforming Design for Large Scale Antenna Arrays
Venue: IEEE Journal of Selected Topics in Signal Processing

The potential of using of millimeter wave (mmWave) frequency for future wireless cellular communication systems has motivated the study of large scale antenna arrays for achieving highly directional beamforming. However, the conventional fully digital beamforming methods which require one radio frequency (RF) chain per antenna element is not viable for large scale antenna arrays due to the high cost and high power consumption of RF chain components in high frequencies. To address the challenge of this hardware limitation, this paper considers a hybrid beamforming architecture in which the overall beamformer consists of a low dimensional digital beamformer followed by an RF beamformer implemented using analog phase shifters. Our aim is to show that such an architecture can approach the performance of a fully digital scheme with much fewer number of RF chains. Specifically, this paper establishes that if the number of RF chains is twice the total number of data streams, the hybrid beamforming structure can realize any fully digital beamformer exactly, regardless of the number of antenna elements. For cases with fewer number of RF chains, this paper further considers the hybrid beamforming design problem for both the transmission scenario of a point to point multiple input multiple output (MIMO) system and a downlink multi user multiple input single output (MU MISO) system. For each scenario, we propose a heuristic hybrid beamforming design that achieves a performance close to the performance of the fully digital beamforming baseline. Finally, the proposed algorithms are modified for the more practical setting in which only finite resolution phase shifters are available. Numerical simulations show that the proposed schemes are effective even when phase shifters with very low resolution are used.
Dental problems and Familismo: social network discussion of oral health issues among adults of Mexican origin living in the Midwest United States.
Venue: Community dental health

To examine the influence of collectivist orientation (often called familismo when applied to the Latino sub group in the United States) in oral health discussion networks. Basic Research Design Through respondent driven sampling and face to face interviews, we identified respondents' (egos) personal social network members (alters) Egos stated whom they talked with about oral health, and how often they discussed dental problems in the preceding 12 months.  An urban community of adult Mexican American immigrants in the Midwest United States. We interviewed 332 egos (90% born in Mexico) egos named an average of 3.9 alters in their networks, 1,299 in total.  We applied egocentric network methods to examine the ego, alter, and network variables that characterize health discussion networks.  Kin were most often leveraged when dental problems arose; egos relied on individuals whom they perceive to have better knowledge about dental matters. However, reliance on knowledgeable alters decreased among egos with greater behavioral acculturation.  This paper developed a network based conceptualization of familismo. We describe the structure of oral health networks, including kin, fictive kin, peers, and health professionals, and examine how networks and acculturation help shape oral health among these Mexican Americans.
Interfacial nano biosensing in microfluidic droplets for high sensitivity detection of low solubility molecules.
Venue: Chemical communications

Taking advantage of the properties of the high surface area to volume ratio of microfluidic droplets, we developed an innovative interfacial nanosensing strategy based on aptamer functionalized graphene oxide nanosensors in microfluidic droplets for the high sensitivity one step detection of 17b estradiol and other low solubility molecules, with the detection sensitivity improved by about 3 orders of magnitude compared to conventional systems.
Optimization of temperature and time for drying and carbonization to increase calorific value of coconut shell using Taguchi method

Fossil fuel still dominates the needs of energy in Indonesia for the past few years. The increasing scarcity of oil and gas from non renewable materials results in an energy crisis. This condition turns to be a serious problem for society which demands immediate solution. One effort which can be taken to overcome this problem is the utilization and processing of biomass as renewable energy by means of carbonization. Thus, it can be used as qualified raw material for production of briquette. In this research, coconut shell is used as carbonized waste. The research aims at improving the quality of coconut shell as the material for making briquettes as cheap and eco friendly renewable energy. At the end, it is expected to decrease dependence on oil and gas. The research variables are drying temperature and time, carbonization time and temperature. The dependent variable is calorific value of the coconut shell. The method used in this research is Taguchi Method. The result of the research shows thus variables.
Carbon cryogel microsphere for ethyl levulinate production: effect of carbonization temperature and time

The side products of biomass and bio fuel industry have shown potential in producing carbon catalyst. The carbon cryogel was synthesized from lignin furfural mixture based on the following details: 1.0 of lignin to furfural (L/F) ratio, 1.0 of lignin to water (L/W) ratio, and 8M of acid concentration. The lignin furfural sol gel mixture, initially prepared via polycondensation reaction at 90 degC for 30 min, was followed by freeze drying and carbonization process. Effects of carbonization temperature and time were investigated on the total acidity and surface area of the carbon cryogel. Furthermore, the effects of these parameters were studied on the ethyl levulinate yield through esterification reaction of levulinic acid in ethanol. The esterification reaction was conducted at reflux temperature, 10 h of reaction time, 19 molar ratio of ethanol to levulinic acid, and 15.0 wt. carbon cryogel loading. Based on the carbonization temperature and time studies, the carbon cryogel carbonized at 500 degC and 4 h exhibited good performance as solid acid catalyst. Large total surface area and acidity significantly influenced the catalytic activity of carbon cryogel with 80.0 wt. yield of ethyl levulinate. Thus, carbon cryogel is highly potential as acid catalyst for the esterification of levulinic acid with ethanol.
The importance of context in logic model construction for a multi site community based Aboriginal driver licensing program.
Venue: Evaluation and program planning

Evidence indicates that Aboriginal people are underrepresented among driver licence holders in New South Wales, which has been attributed to licensing barriers for Aboriginal people. The Driving Change program was developed to provide culturally responsive licensing services that engage Aboriginal communities and build local capacity.  This paper outlines the formative evaluation of the program, including logic model construction and exploration of contextual factors.  Purposive sampling was used to identify key informants (n=12) from a consultative committee of key stakeholders and program staff. Semi structured interviews were transcribed and thematically analysed. Data from interviews informed development of the logic model.  Participants demonstrated high level of support for the program and reported that it filled an important gap. The program context revealed systemic barriers to licensing that were correspondingly targeted by specific program outputs in the logic model. Addressing underlying assumptions of the program involved managing local capacity and support to strengthen implementation.  This formative evaluation highlights the importance of exploring program context as a crucial first step in logic model construction. The consultation process assisted in clarifying program goals and ensuring that the program was responding to underlying systemic factors that contribute to inequitable licensing access for Aboriginal people.