nils-herrmann/clean_scirepeval huggingface dataset:
Guillain Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case control study
Venue: The Lancet

Between October, 2013, and April, 2014, French Polynesia experienced the largest Zika virus outbreak ever described at that time. During the same period, an increase in Guillain Barre syndrome was reported, suggesting a possible association between Zika virus and Guillain Barre syndrome. We aimed to assess the role of Zika virus and dengue virus infection in developing Guillain Barre syndrome.  In this case control study, cases were patients with Guillain Barre syndrome diagnosed at the Centre Hospitalier de Polynesie Francaise (Papeete, Tahiti, French Polynesia) during the outbreak period. Controls were age matched, sex matched, and residence matched patients who presented at the hospital with a non febrile illness (control group 1; n=98) and age matched patients with acute Zika virus disease and no neurological symptoms (control group 2; n=70) Virological investigations included RT PCR for Zika virus, and both microsphere immunofluorescent and seroneutralisation assays for Zika virus and dengue virus. Anti glycolipid reactivity was studied in patients with Guillain Barre syndrome using both ELISA and combinatorial microarrays.  42 patients were diagnosed with Guillain Barre syndrome during the study period. 41 (98% patients with Guillain Barre syndrome had anti Zika virus IgM or IgG, and all (100% had neutralising antibodies against Zika virus compared with 54 (56% of 98 in control group 1 (p<0.0001) 39 (93% patients with Guillain Barre syndrome had Zika virus IgM and 37 (88% had experienced a transient illness in a median of 6 days (IQR 4 10) before the onset of neurological symptoms, suggesting recent Zika virus infection. Patients with Guillain Barre syndrome had electrophysiological findings compatible with acute motor axonal neuropathy (AMAN) type, and had rapid evolution of disease (median duration of the installation and plateau phases was 6 [IQR 4 9] and 4 days [3 10] respectively) 12 (29% patients required respiratory assistance. No patients died. Anti glycolipid antibody activity was found in 13 (31% patients, and notably against GA1 in eight (19% patients, by ELISA and 19 (46% of 41 by glycoarray at admission. The typical AMAN associated anti ganglioside antibodies were rarely present. Past dengue virus history did not differ significantly between patients with Guillain Barre syndrome and those in the two control groups (95% 89% and 83% respectively) INTERPRETATION This is the first study providing evidence for Zika virus infection causing Guillain Barre syndrome. Because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillain Barre syndrome.
Zika Virus and Birth Defects Reviewing the Evidence for Causality.
Venue: The New England journal of medicine

The Zika virus has spread rapidly in the Americas since its first identification in Brazil in early 2015. Prenatal Zika virus infection has been linked to adverse pregnancy and birth outcomes, most notably microcephaly and other serious brain anomalies. To determine whether Zika virus infection during pregnancy causes these adverse outcomes, we evaluated available data using criteria that have been proposed for the assessment of potential teratogens. On the basis of this review, we conclude that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Evidence that was used to support this causal relationship included Zika virus infection at times during prenatal development that were consistent with the defects observed; a specific, rare phenotype involving microcephaly and associated brain anomalies in fetuses or infants with presumed or confirmed congenital Zika virus infection; and data that strongly support biologic plausibility, including the identification of Zika virus in the brain tissue of affected fetuses and infants. Given the recognition of this causal relationship, we need to intensify our efforts toward the prevention of adverse outcomes caused by congenital Zika virus infection. However, many questions that are critical to our prevention efforts remain, including the spectrum of defects caused by prenatal Zika virus infection, the degree of relative and absolute risks of adverse outcomes among fetuses whose mothers were infected at different times during pregnancy, and factors that might affect a woman's risk of adverse pregnancy or birth outcomes. Addressing these questions will improve our ability to reduce the burden of the effects of Zika virus infection during pregnancy.
Deadline Constrained Workflow Scheduling Optimization by Initial Seeding with ANT Colony Optimization

Cloud computing is a new model of service provisioning in distributed systems. It encourages researchers to investigate its benefits and drawbacks on executing scientific applications such as workflows. One of the most challenging problems in workflow scheduling in cloud environment is its quality of service, which minimizes the cost of computation of workflows. In this paper, we use the Predicted Earliest finish time (PEFT) for initial seeding to Ant Colony optimization technique (ACO) As we know ACO is a very powerful technique appropriate for optimization. The increasing complexity of the workflow applications is forcing researchers to explore hybrid approaches to solve the workflow scheduling problem. In this paper we proposed PEFT with ACO algorithm which reduces the initialization complexity and converge ACO algorithm.
Cost optimization approaches for scientific workflow scheduling in cloud and grid computing: A review, classifications, and open issues
Venue: J. Syst. Softw.

Workflow scheduling in scientific computing systems is one of the most challenging problems that focuses on satisfying user defined quality of service requirements while minimizing the workflow execution cost. Several cost optimization approaches have been proposed to improve the economic aspect of Scientific Workflow Scheduling (SWFS) in cloud and grid computing. To date, the literature has not yet seen a comprehensive review that focuses on approaches for supporting cost optimization in the context of SWFS in cloud and grid computing. Furthermore, providing valuable guidelines and analysis to understand the cost optimization of SWFS approaches is not well explored in the current literature. This paper aims to analyze the problem of cost optimization in SWFS by extensively surveying existing SWFS approaches in cloud and grid computing and provide a classification of cost optimization aspects and parameters of SWFS. Moreover, it provides a classification of cost based metrics that are categorized into monetary and temporal cost parameters based on various scheduling stages. We believe that our findings would help researchers and practitioners in selecting the most appropriate cost optimization approach considering identified aspects and parameters. In addition, we highlight potential future research directions in this on going area of research.
Online optimization scheduling for scientific workflows with deadline constraint on hybrid clouds
Venue: Concurr. Comput. Pract. Exp.

The tremendous parallel computing ability of cloud computing encourages investigators to research its drawbacks and advantages on processing large scale scientific applications such as workflows. The current cloud market is composed of numerous diverse public clouds and a local private cloud, and workflow scheduling is one of the biggest challenges on hybrid clouds due to the highly fragmented cloud market with respect to service provisions, pricing models, and bandwidths. In this paper, we propose an online scheduling strategy for continuous submitted scientific workflows on hybrid clouds, which aims to complete the deadline constrained applications as more as possible at a lower price. Firstly, a hierarchical iterative application partition (HIAP) algorithm is proposed to partition the application into a set of dependent tasks. Moreover, many online scheduling algorithms cooperated with HIAP are presented to finish the workflows with a low average payment. Our strategy takes into account the basic characteristics on hybrid clouds such as bandwidth constraints, data transfer cost and computational cost. Various well known workflows are used for evaluating the multiple scheduling algorithms and the results show that the MLF_ID approach can achieve a promising performance.
Great expectations: An analysis of major league baseball free agent performance
Venue: Stat. Anal. Data Min.

We explore whether free agents in Major League Baseball meet the expectations set forth by newly signed contracts. The value and duration of these contracts are negotiated between the player and his agent and the signing team and are based primarily on the player's performance to date, projected future performance, and potential marketing value to the team. We develop two classes of models to explore this problem using a variety of regression and tree based machine learning algorithms. The market model uses player and team data to predict the market value of a player's performance i.e. average contract salary. The performance model uses the same data to predict wins above replacement as a surrogate for overall player performance. We translate this measure into dollars using position based conversion factors. Analysis of these models demonstrates that the performance model more consistently predicts and assesses player value with respect to their free agent contracts. Together, these models can be used to target or avoid free agents or other players whose performance based value differs significantly from their market value.
Front end definition of projects: Ten paradoxes and some reflections regarding project management and project governance

The importance of the front end decision making phase in securing projects long term success is being increasingly recognized. This area is underrepresented in the literature, but there are several key themes that run throughout, identifying key issues or difficulties during this stage. Clearly, a key to successful projects lies in the choice of concept. This paper presents some findings from the work of the Concept research programme on front end management and governance of major public investment projects in Norway. It is based on studies that explore strengths and weaknesses in the processes of analysis and decision making during the early phase before the final choice of conceptual solution is made, and the extent to which projects under study are (or are likely to be) relevant and effective in relation to needs and priorities in society. It concludes that there are frequent deficiencies in these processes, and that the potential for improvements is huge.
The Griffith formula and J integral for elastic bodies with Timoshenko inclusions

The paper contains an analysis of a two dimensional equilibrium problem for an elastic body with a thin elastic inclusion. The thin elastic inclusion is modeled within the framework of Timoshenko beam theory. There is a crack on the interface between two media, displacements of the opposite crack faces are constrained with nonpenetration conditions. We derive the Griffith formula, which gives the first derivative of the energy functional with respect to the crack length. It is proved that the formula for the derivative can be represented as a path independent integral along a smooth curve surrounding the crack tip. The invariant integral consists of a regular part and a singular part and is an analogue of the classical Eshelby Cherepanov Rice J integral.
Study of rock splitting failure based on griffith strength theory

It is argued here that often cited result that the Griffith theory leads to a uniaxial compressive strength that is twelve times greater than uniaxial tensile strength is erroneous. A uniaxial compressive load can lead to the maximum tensile stress at longitudinal crack tips when the ratio of minor axis to major axis of the Griffith's crack is finitely small, but it is smaller than the maximum tensile stress of inclined crack under the same pressure. According to the characteristics of the maximum tensile stress distribution on the perimeter of the Griffith's crack, and the splitting characteristics of rock failure process, the conditions of axial splitting failure of rock specimens are proposed, and the mechanism of splitting fracturing of rock specimens is clarified as well.
Bacterial Cellulose: A Robust Platform for Design of Three Dimensional Carbon Based Functional Nanomaterials.
Venue: Accounts of chemical research

Three dimensional (3D) carbon nanomaterials exhibit great application potential in environmental protection, electrochemical energy storage and conversion, catalysis, polymer science, and advanced sensors fields. Current methods for preparing 3D carbon nanomaterials, for example, carbonization of organogels, chemical vapor deposition, and self assembly of nanocarbon building blocks, inevitably involve some drawbacks, such as expensive and toxic precursors, complex equipment and technological requirements, and low production ability. From the viewpoint of practical application, it is highly desirable to develop a simple, cheap, and environmentally friendly way for fabricating 3D carbon nanomaterials in large scale. On the other hand, in order to extend the application scope and improve the performance of 3D carbon nanomaterials, we should explore efficient strategies to prepare diverse functional nanomaterials based on their 3D carbon structure. Recently, many researchers tend to fabricate high performance 3D carbon based nanomaterials from biomass, which is low cost, easy to obtain, and nontoxic to humans. Bacterial cellulose (BC) a typical biomass material, has long been used as the raw material of nata de coco (an indigenous dessert food of the Philippines) It consists of a polysaccharide with a b 1,4 glycosidic linkage and has a interconnected 3D porous network structure. Interestingly, the network is made up of a random assembly of cellulose nanofibers, which have a high aspect ratio with a diameter of 20 100 nm. As a result, BC has a high specific surface area. Additionally, BC hydrogels can be produced on an industrial scale via a microbial fermentation process at a very low price. Thus, it can be an ideal platform for design of 3D carbon based functional nanomaterials. Before our work, no systematic work and summary on this topic had been reported. This Account presents the concepts and strategies of our studies on BC in the past few years, that is, converting cheap biomass into high value added 3D carbon nanomaterials and designing diverse functional materials on 3D carbon structure. We first briefly introduce the history, constituent, and microstructure features of BC and discuss its advantages as a raw material for preparing the CNF aerogels. Then, we summarize the methods and strategies for preparing various 3D carbon based nanomaterials from BC. In addition, the potential applications of the developed CNF aerogel based functional materials are also highlighted in this Account, including stretchable conductors, oxygen reduction reaction catalysts, supercapacitors, lithium ion battery, and oil cleanup. Finally, we give some prospects on the future challenges in this emerging research area of designing CNF aerogel based functional nanomaterials from BC.
Metastatic non small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up.
Venue: Annals of oncology official journal of the European Society for Medical Oncology

S. Novello1, F. Barlesi2, R. Califano3,4, T. Cufer5, S. Ekman6, M. Giaj Levra7, K. Kerr8, S. Popat9, M. Reck10, S. Senan11, G. V. Simo12, J. Vansteenkiste13 S. Peters14 on behalf of the ESMO Guidelines Committee* Oncology Department, University of Turin, AOU San Luigi Orbassano, Orbassano, Italy; Assistance Publique Hopitaux de Marseille, Multidisciplinary Oncology and Therapeutic Innovations Department, Aix Marseille University, Marseille, France; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester; Department of Medical Oncology, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK; Medical Faculty Ljubljana, University Clinic Golnik, Golnik, Slovenia; Department of Oncology, Karolinska University Hospital, Stockholm, Sweden; Thoracic Oncology Unit, Centre Hospitalier Universitaire Grenoble Alpes (CHUGA) Grenoble, France; Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Aberdeen; Department of Medicine, Royal Marsden Hospital, London, UK; Department of Thoracic Oncology, LungenClinic Grosshansdorf, Airway Research Center North (ARCN) Member of the German Centre for Lung Research (DZL) Grosshansdorf, Germany; Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands; Thoracic Surgery Service, Salamanca University Hospital, Salamanca, Spain; Respiratory Oncology Unit (Pulmonology) University Hospital KU Leuven, Leuven, Belgium; Oncology Department, Centre Hospitalier Universitaire Vaudois (CHUV) Lausanne, Switzerland
gH2AX formation kinetics in PBMCs of rabbits exposed to acute and fractionated radiation and attenuation of focus frequency through preadministration of a combination of podophyllotoxin and rutin hydrate
Venue: Environmental and molecular mutagenesis

DNA damage can be assessed by the quantitation of gH2AX foci that form at DSB sites. This study examines the generation and persistence of gH2AX foci, variability in foci size after acute and fractionated radiation exposure, and the effect of pretreatment with a safe radioprotective formulation termed G 003M on foci generation and persistence. G 003M contains a combination of podophyllotoxin and rutin hydrate, and was administered intramuscularly to rabbits 1 hr prior to Co60 gamma irradiation. Rabbits were assigned to one of the following treatment groups: untreated, G 003M alone, irradiated (single dose 8 Gy, fractionated 2 Gy/day for 4 days or single dose 2 Gy) or G 003M preadministration followed by radiation exposure. Foci continuously persisted for a week in peripheral blood mononuclear cells of rabbits exposed to a single 8 Gy dose. However, the number of foci gradually decreased after reaching a maximum at 1 h. In rabbits exposed to fractionated radiation, foci detected 1 hr after the final exposure were significantly larger (P 0.001) than in rabbits exposed to a single 8 Gy dose, but disappeared completely after 24 h. In both groups, foci reappeared on days 11 15 in terminally ill animals. G 003M pretreatment significantly (P 0.05) attenuated the formation of gH2AX foci in all irradiated rabbits. This study reveals that gH2AX focus assessment could be used to confirm radiation exposure, that focus size reflects the type of radiation exposure (acute or fractionated) that the re appearance of foci is a strong indicator of imminent death in animals, and that G 003M provides protection against radiation.  2016.
Critical incident analysis: reflections of a teacher educator

As a teacher educator I consider myself an advocate for research informed education, and strongly believe that it starts with one's own critical self reflection and analysis of one's own teaching practice. Critical incident analysis is a pedagogical theory developed by Tripp (1993) whose analytical approaches allow reflection on teaching situations 'the critical incident' so that teachers can develop their professional judgments and practices. This article examines the concept of critical incident analysis through a teaching situation, with the aim of improving the teaching practice of students on teacher education programmes. I conclude that although critical incident analysis is a useful tool in navigating teaching practices, often challenges need to be addressed at much broader levels than the teaching context itself.
A COMPARATIVE STUDY ON THERMAL CONDUCTIVITY OF Al 2 O 3 WATER CuO WATER AND Al 2 O 3 CuO WATER NANOFLUIDS

In this present study, the thermal conductivity of Al2O3/water, CuO/water and Al2O3 CuO/water hybrid nanofluid were investigated experimentally. The two step method was adopted to prepare the hybrid nanofluid. Three different volume concentrations of nanofluids (0.05, 0.1 0.2% were prepared by dispersing Al2O3 and CuO nanoparticles in water. The properties of single and hybrid nanofluids were measured by varying the temperature from 20 0 C to 60 0 C. The obtained results demonstrate that the thermal conductivity of nanofluids are the function of volume concentration and temperature. Also the experimental results showed that a maximum of 9.8 enhancement of thermal conductivity was observed for 0.2% particle volume concentration. The experimental thermal conductivity values were compared with the theoretical thermal conductivity values.
Numerical Simulation into the Convective Heat Transfer of Al 2 O 3 and Cuo Nanofluids Flowing through a Straight Tube Using the Two Phase Modeling

The main purpose of this study is focused on numerical investigation of thermal behavior of Copper oxide water nanofluids and Aluminum oxide water nanofluids inside a horizontal heated tube. The model has been solved by using the two phase models with four correlations of thermal conductivity. The discretization of equations of continuity, momentum, and energy has been done using the Finite Volume Method. A uniform and constant heat flux has been applied at the wall boundary conditions. The results show that the heat transfer coefficient predicted by the two phase model is enhanced by increasing the volume fraction of nanoparticles for all Peclet numbers; when the Peclet number is low, increasing the volume fraction of nanoparticles will enhance the convective heat transfer in the entrances region of the pipe and gradually decrease along the axial distance of the channel. Also, it is found that the enhanced heat transfer is greater for use the models of thermal conductivity which depend on the temperature than in the constant models. Comparison between predicted results and experimental data from literature is carried out which indicates the two phase is more precise.
A survey of security and privacy in big data
Venue: 2016 16th International Symposium on Communications and Information Technologies (ISCIT)

Big data has been arising a growing interest in both scientific and industrial fields for its potential value. However, before employing big data technology into massive applications, a basic but also principle topic should be investigated: security and privacy. In this paper, the recent research and development on security and privacy in big data is surveyed. First, the effects of characteristics of big data on information security and privacy are described. Then, topics and issues on security are discussed and reviewed. Further, privacy preserving trajectory data publishing is studied due to its future utilization, especially in telecom operation.