nils-herrmann/clean_scirepeval huggingface dataset:
CubeQA Question Answering on RDF Data Cubes
Venue: SEMWEB

Statistical data in the form of RDF Data Cubes is becoming increasingly valuable as it influences decisions in areas such as health care, policy and finance. While a growing amount is becoming freely available through the open data movement, this data is opaque to laypersons. Semantic Question Answering (SQA) technologies provide intuitive access via free form natural language queries but general SQA systems cannot process RDF Data Cubes. On the intersection between RDF Data Cubes and SQA, we create a new subfield of SQA, called RDCQA. We create an RDQCA benchmark as task 3 of the QALD 6 evaluation challenge, to stimulate further research and enable quantitative comparison between RDCQA systems. We design and evaluate the domain independent CubeQA algorithm, which is the first RDCQA system and achieves a global (F_1\ score of 0.43 on the QALD6T3 test benchmark, showing that RDCQA is feasible.
Predicting Gross Domestic Product Components through Tsallis Entropy Econometrics

This article proposes the Tsallis non extensive entropy econometric approach to forecast components of the country gross domestic product based on the knowledge of time series macroeconomic aggregates of the past period, plus some sparse and imperfect information of the current period. Non extensive entropy technique has proved to remain a good modelling device not only in the case of high frequency series, but also in the case of aggregated series. To predict the missing GDP components, we set up a q generalized Kullback Leibler information divergence criterion function with a priori consistency, GDP related macroeconomic constraints and regular conditions. The model forecasts are compared to the official Polish GDP components of the corresponding period. The proposed Tsallis entropy approach leads to high predictive performance and shows a stronger estimation stability through different model simulations than the traditional Shannon model. Furthermore, as expected this Tsallis related approach seems to reflect a higher stability through parameter computation and simulation in comparison with the traditional Shannon Gibbs entropy technique.
Silymarin and Hydroethanolic Extracts of Silybum marianum Leaves and Fruits Attenuate Diethylnitrosamine/Phenobarbital Induced Nephrotoxicity via Their Antioxidant and Anti Inflammatory Actions

The current study was designed to evaluate the possible preventive effects of silymarin and hydroethanolic extracts of Silybum marianum leaves and fruits on diethylnitrosamine (DEN)/phenobarbital (PB) induced nephrotoxicity in rats. The albino rats used in this study were allocated into 5 groups. Group I was kept as a normal control group, while the other 4 groups were administered a single intraperitoneal dose (200 mg/kg) of DEN, followed by daily PB administration in drinking water from the 3rd week till the end of the experiment. Group II was DEN/PB administered control group and groups III, IV and V were administered DEN and PB and were orally given silymarin, milk thistle leaves and milk thistle fruits extracts at a dose of 10, 50 and 50 mg/kg/day, respectively, for 14 weeks. DEN/PB administrations induced kidney injury evidenced by histological alterations as well as significant increase of serum urea and creatinine concentrations. They also produced a significant increase in serum TNF a level and a significant decrease in serum adiponectin level. On the other hand, the renal lipid peroxidation was elevated while renal glutathione content and activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione s transferase were significantly declined as a result of DEN/PB administrations. Concomitant supplementation with silymarin and hydroethanolic extracts of Silybum marianum leaves and fruits markedly alleviated the altered biochemical and histopathological features. Thus, it can be concluded that silymarin and hydroethanolic extracts of milk thistle leaves and fruits successfully attenuate the DEN/PB induced nephrotoxicity via their antioxidant and anti inflammatory actions.
Ameliorative Effects of Quercetin and Naringenin on Diethylnitrosamine/2 acetyl aminoflourene Induced Nephrotoxicity in Male Wistar Rats

Nephrotoxicity is one of the most widespread kidney tribulations. Quercetin and naringenin are natural flavonoids highly enriched in fruits, and vegetables which have a bioactive effect on human health. The current study was designed to evaluate the preventive effects of quercetin and naringenin on Diethylnitrosamine (DEN)/2 Acetylaminofluorene (2AAF) induced nephrotoxicity in rats. The Wistar rats used in this study were allocated into 4 groups. The 1st group was kept as a normal group while the other 3 groups were intraperitoneally administered DEN (150 mg/kg b.w./week for two weeks) dissolved in 0.9% saline at the beginning of experiment. One week after the last injection of DEN, 2 AAF was orally administrated at dose 20 mg/kg b.w. in 1% tween 80 four days per week for three weeks. One of the three DEN/2AAF administered groups was kept as control and the others were orally treated with quercetin and naringenin at dose 10 mg/kg b.w. every other day for 20 weeks. DEN/2AAF administration induced kidney injury evidenced by histological alterations as well as significant increases of serum creatinine, urea and uric acid concentrations. There was also a significant increase in the levels of renal lipid peroxidation and nitric oxide. Moreover, renal glutathione content and activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione s transferase were significantly declined as a result DEN/2AAF administration. The treatments of DEN/2AAF administered rats with the two flavonoids quercetin and naringenin successfully amended kidney histological perturbations and improved serum markers related to kidney function in association with alleviation of the deteriorated kidney oxidative stress and anti oxidant defense system. In conclusion, quercetin and naringenin successfully attenuate the DEN/2AAF induced nephrotoxicity and this effect may be mediated via suppression of the oxidative stress and stimulation of the antioxidant defense system.
Decidual macrophages: key regulators of vascular remodeling in human pregnancy
Venue: Journal of leukocyte biology

Successful remodeling of the uterine spiral arteries is essential for a complication free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistochemical assessment of placental bed biopsies demonstrated uterine NK cells, macrophages, and T lymphocytes in the wall and adventitia of spiral arteries at different stages of remodeling, regardless of the presence of extravillous trophoblast cells. Leukocytes were more prevalent in vessel adventitia than wall, and macrophages were the most abundant leukocyte population. Macrophages, separated from early pregnancy decidua, did not alter extravillous trophoblast cells invasion or vascular smooth muscle cell organization or differentiation status but did induce extracellular matrix breakdown (reduced immunostaining of laminin, P 0.05; fibronectin, P 0.02) and were able to phagocytose apoptotic vascular smooth muscle cells. Decidual macrophages were shown to secrete a wide range of cytokines (IL 1b, 2, 4, 5, 6, 8, 10, and 13 and TNF a) proteases (matrix metalloproteinase 1, 2, 7, 9, and 10) and angiogenic growth factors (angiogenin, keratinocyte growth factor, fibroblast growth factor B, vascular endothelial growth factor A, and angiopoietin 1 and 2) We conclude that spiral artery remodeling involves the coordinated activity of a range of cell types, including extravillous trophoblast cells, decidual uterine NK cells, and macrophages in a carefully, spatiotemporally regulated manner.
Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006 2013
Venue: Diabetes Care

To examine temporal trends in utilization of glucose lowering medications, glycemic control, and rate of severe hypoglycemia among patients with type 2 diabetes (T2DM) RESEARCH  Using claims data from 1.66 million privately insured and Medicare Advantage patients with T2DM from 2006 to 2013, we estimated the annual 1) age and sex standardized proportion of patients who filled each class of agents; 2) age sex race and region standardized proportion with hemoglobin A1c (HbA1c) <6% 6 to <7% 7 to <8% 8 to <9% =9% and 3) age and sex standardized rate of severe hypoglycemia among those using medications. Proportions were calculated overall and stratified by age group (18 44, 45 64, 65 74, and =75 years) and number of chronic comorbidities (zero, one, and two or more)  From 2006 to 2013, use increased for metformin (from 47.6 to 53.5% dipeptidyl peptidase 4 inhibitors (0.5 to 14.9% and insulin (17.1 to 23.0% but declined for sulfonylureas (38.8 to 30.8% and thiazolidinediones (28.5 to 5.6% all P 0.001) The proportion of patients with HbA1c <7% declined (from 56.4 to 54.2% P 0.001) and with HbA1c =9% increased (9.9 to 12.2% P 0.001) Glycemic control varied by age and was poor among 23.3% of the youngest and 6.3% of the oldest patients in 2013. The overall rate of severe hypoglycemia remained the same (1.3 per 100 person years; P 0.72) declined modestly among the oldest patients (from 2.9 to 2.3; P 0.001) and remained high among those with two or more comorbidities (3.2 to 3.5; P 0.36)  During the recent 8 year period, the use of glucose lowering drugs has changed dramatically among patients with T2DM. Overall glycemic control has not improved and remains poor among nearly a quarter of the youngest patients. The overall rate of severe hypoglycemia remains largely unchanged.
Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia
Venue: Diabetes Care

Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D) Current therapies are effective in preventing SHEs in 50 80% of patients with IAH and SHEs, leaving a substantial number of patients at risk. We evaluated the effectiveness and safety of a standardized human pancreatic islet product in subjects in whom IAH and SHEs persisted despite medical treatment.  This multicenter, single arm, phase 3 study of the investigational product purified human pancreatic islets (PHPI) was conducted at eight centers in North America. Forty eight adults with T1D for >5 years, absent stimulated C peptide, and documented IAH and SHEs despite expert care were enrolled. Each received immunosuppression and one or more transplants of PHPI, manufactured on site under good manufacturing practice conditions using a common batch record and standardized lot release criteria and test methods. The primary end point was the achievement of HbA1c <7.0% (53 mmol/mol) at day 365 and freedom from SHEs from day 28 to day 365 after the first transplant.  The primary end point was successfully met by 87.5% of subjects at 1 year and by 71% at 2 years. The median HbA1c level was 5.6% (38 mmol/mol) at both 1 and 2 years. Hypoglycemia awareness was restored, with highly significant improvements in Clarke and HYPO scores (P 0.0001) No study related deaths or disabilities occurred. Five of the enrollees (10.4% experienced bleeds requiring transfusions (corresponding to 5 of 75 procedures) and two enrollees (4.1% had infections attributed to immunosuppression. Glomerular filtration rate decreased significantly on immunosuppression, and donor specific antibodies developed in two patients.  PHPI provided glycemic control, restoration of hypoglycemia awareness, and protection from SHEs in subjects with intractable IAH and SHEs. Safety events occurred related to the infusion procedure and immunosuppression, including bleeding and decreased renal function. Islet transplantation should be considered for patients with T1D and IAH in whom other, less invasive current treatments have been ineffective in preventing SHEs.
05) A Maquina que Mudou o Mundo: Baseado no Estudo do Massachusetts Institute of Tecnology sobre o Futuro do Autom

Diante do tamanho do impacto que causou na industria automobilistica, "A maquina que mudou o mundo" se tornou um classico mundial que revolucionou o processo de producao automobilistico. Baseado numa intensa pesquisa realizada em 14 paises espalhados pelo mundo, nas mais diversas montadoras de automoveis, com a duracao de cinco anos e orcado em cinco milhoes de dolares, o livro e um empreendimento que lida com o processo de transformacao do sistema de producao em massa para producao enxuta.
The Intelligent Crude Oil Anti theft System Based on IoT Under Different Scenarios
Venue: KES

Oil theft always results in huge economic loss, human casualties, and extremely environmental pollution especially when the leaks from crude oil pipeline are not detected and repaired timely. In this paper, we focus on how to detect and monitor abnormal noise and vibration beforehand or in real time by the Internet of Things (IoT) Firstly, the diversities of crude oil theft and the difficulties of oil anti theft are analyzed in China, and the requirement analysis of the IoT application is stated. Secondly, the intelligent anti theft system based on the IoT is planned and designed for crude oil transportation by tank trucks and by oil pipelines according to the current situation in China. Thirdly, the problems of anti theft system implementation are discussed, and the suggestions and advice are put forward to ensure that the system can be implemented successfully. The intelligent anti theft system application can not only stop oil theft timely, but also prevent oil mice from stealing crude oil beforehand.
Intelligent Anti Theft System for Automobiles

Security is prime sympathy toward everybody. These days all the car are outfitted with auto cop systems. Despite the fact that, the criminals are breaking the obstructions and take the vehicles. This venture is the right answer for this issue. Utilizing this venture, one can control his vehicle's car engine by method for a SMS. Hence, to conquer the above disadvantages, we are utilizing one of the remote correspondence procedure i.e. GSM (Global System for Mobile communications) is a digital cellular communications system which has quickly picked up acknowledgment and piece of the pie around the world. ARM is the heart of the task. A GSM modem is interfaced to microcontroller. This modem receives the messages from control mobile and sends as contribution to MCU. The MCU check for validation o and, in the event that IT is approved, engine control will be taken place.16X2 LCD is interfaced to show client required information. In this task TRAIC is utilized as burden controller (as a switch) MOC3021 utilized as a Triac driver. This undertaking utilizes controlled 5v, 750mA power supply. 7805 and 7812 three terminal voltage controllers are utilized for voltage direction. Bridge type full wave rectifier is utilized to redress the air conditioner yield of auxiliary of 230/12v step down transformer. The report comprises of a foundation into the territory of ARM microcontroller and mobile correspondence, how they are interfaced to each other and AT (Attention) summons set utilized as a part of correspondence.
The role of a technical customer in organization of investment and construction activity at the stage of construction oversight

This document considers the main tasks promoting development of construction as a branch and defines the correlation of efficiency of using funds with the activity of the technical customer as a guarantor of completing the design and construction works with proper quality, within established periods and planned financing of the facility construction. The functions of the technical customer and developer are defined from the point of view of the law as well as reasonability of their simultaneous work in the form of various legal entities in organization of design and survey works. Goals and objectives of the construction oversight are determined in accordance with regulatory documents, on the basis of which the package of functional procedures of the construction control is identified. Organization and management model of the technical customer's activity at the construction oversight stage is developed in the form of network and linear diagrams aiding in establishing the conditions of the construction oversight function execution with account of assuring the quality of the finished product.
A service oriented framework for agent based simulations of collaborative supply chains
Venue: Comput. Ind.

A systematic and reusable service oriented simulation framework for supply chain simulation is presented.The framework is capable of representing complex collaborative interactions using the agent paradigm.The development of models for studying supply chain collaboration is accelerated.The framework is implemented and validated using a general purpose agent based simulation platform, Anylogic 6.8. Current collaborative practices of supply chain management are limited to some known configurations where a dominant member sets the pace for the collaboration extent. Extending collaborative models to supply chains without a dominant member requires defining a fair assessment of costs and benefits and how they are distributed among members. To understand collaborative models and their mechanisms, simulation based approaches are recommended as they can afford the complexity of real scenarios. However, building ad hoc simulation models for studying complex supply chain interactions can be prohibitive in terms of both cost and time. Therefore, the availability of simulation frameworks, to be used easily by business managers and facilitating the development of those models, has a strong incentive in the quest of current business efforts to increase their supply chain performance. The objective of this work is to present a systematic and reusable serviceoriented framework for agent based simulation to support the analysis of collaborative interactions in supply chains. Results of a requirement analysis performed to this aim are described, and the fulfillment of identified requirements by the proposed framework, and capabilities thereof, are discussed.
Toward the New Version of D MASON: Efficiency, Effectiveness and Correctness in Parallel and Distributed Agent Based Simulations
Venue: 2016 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW)

Agent Based Models (ABMs) denote a class of models which, by simulating the behavior of multiple agents (i.e. independent actions, interactions and adaptation) aim to emulate and/or predict complex phenomena. One of the general features of ABM simulations is their experimental capacity, that requires a viable and reliable infrastructure to interact with a running simulation, monitoring its behaviour, as it proceeds, and applying changes to the configurations at run time, in order to study "what if" scenarios. A common approach for improving the efficiency and the effectiveness of ABMs as a research tool is to distribute the overall computation on a number of machines, which makes the design of the simulation model particularly challenging. D MASON framework is a distributed version of the MASON library for writing and running Agent based simulations. We briefly present D MASON architecture and functionalities. Then we presents its novel features: a distributed network field and a novel communication layer dedicated to massive parallel machines. The main contribution of the paper is in providing a memory consistency modeling, where the previous state of theagent is made available (consistently) for all other agents (even the one on other processors) and this is obtained by exploiting the Java Method Handler mechanism. Full documentation, additional tutorials and other material can be found at www.dmason.org where the framework can be downloaded.
Abstract P1 14 10: Phase II trial of neoadjuvant chemotherapy with carboplatin and nab paclitaxel in patients with triple negative locally advanced and inflammatory breast cancer

Pathologic complete response (pCR) and residual cancer burden (RCB scores of 0 [pCR] or 1[near CR] after neoadjuvant chemotherapy (NCT) may predict for improved survival (Symmans et al.  2007) We set out to test the pCR rate with an anthracycline free regimen of carboplatin (carb) and nab paclitaxel (nab) in patients (pts) with triple negative breast cancer (TNBC)  Forty nine pts with stages II III BC were to receive carb (AUC 6) on day 1 of a 28 day cycle, and nab 80 mg/m2 weekly, for a total of 4 cycles. Core biopsies were performed prior to NCT. Blood procurement for circulating tumor cell (CTC) analysis using the CellSearch platform was carried out pre treatment, mid treatment, and at surgery. We set out to assess the predictive value of Mammaprint (poor vs. good) BluePrint (basal, vs. luminal, vs. HER2) molecular subtype as well as microarray RNA and miRNA profiling, for pCR. Responses were also dichotomized as complete or near complete response (Symmans RCB scores of 0 1) vs. suboptimal response (RCB score 1)  The median age was 53 (28 75) Pts presented with clinical stages II (63% and III (37% So far, 38 of the 49 pts accrued between 2/2012 and 6/2015, have undergone surgery, 68% of whom underwent modified radical mastectomy. The pCR rate (breast and lymph nodes in CR) was 53% and RCB 0 and 1 were seen in 68% of pts. Toxicites included grade 3/4 anemia (45% thrombocytopenia (13% and neutropenia (53%,1 pt with neutropenic fever) Dose adjustments were needed in over 80% of pts. Grades 2 or 3 peripheral neuropathy were seen in 8% each, and grades 3 4 fatigue (13% hypokalemia (3% and hyponatremia (3% were observed. The median number of CTCs (pre NCT) observed in 7 CTC positive pts of the first 27 pts who completed surgery was 1 (0 7) and 2 of the 7 pts continued to have CTCs at the time of surgery (1 CTC each) while 2 pts without CTCs pre NCT had CTCs (1 each) detected at surgery. The final pt enrolled is expected to complete surgery by 10/2015. Results of sequential CTC assessments, MammaPrint/Blueprint and RNA/miRNA analysis of pre and post treatment specimens and their correlation with pCR will be presented.  The non anthracycline containing regimen of carb and nab paclitaxel induced a high pCR rate in TNBC, in preliminary analysis. Ongoing profiling may allow for future subset specific modification of this regimen to increase pCR across all molecular subtypes of TNBC.  Somlo G, Chung S, Frankel P, Hurria A, Koehler S, Kruper L, Mortimer JE, Paz B, Robinson K, Taylor L, Vito C, Waisman J, Yeon C, Yim J, Yuan Y, Tong T. Phase II trial of neoadjuvant chemotherapy with carboplatin and nab paclitaxel in patients with triple negative locally advanced and inflammatory breast cancer.