nils-herrmann/clean_scirepeval huggingface dataset:
Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry Based Phosphotyrosine Proteomics
Venue: Clinical Cancer Research

Targeted therapies in renal cell carcinoma (RCC) are limited by acquired resistance. Novel therapeutic targets are needed to combat resistance and, ideally, target the unique biology of RCC subtypes.  Tyrosine kinases provide critical oncogenic signaling and their inhibition has significantly impacted cancer care. To describe a landscape of tyrosine kinase activity in RCC that could inform novel therapeutic strategies, we performed a mass spectrometry based system wide survey of tyrosine phosphorylation in 10 RCC cell lines as well as 15 clear cell and 15 papillary RCC human tumors. To prioritize identified tyrosine kinases for further analysis, a 63 tyrosine kinase inhibitor (TKI) drug screen was performed.  Among the cell lines, 28 unique tyrosine phosphosites were identified across 19 kinases and phosphatases including EGFR, MET, JAK2, and FAK in nearly all samples. Multiple FAK TKIs decreased cell viability by at least 50% and inhibited RCC cell line adhesion, invasion, and proliferation. Among the tumors, 49 unique tyrosine phosphosites were identified across 44 kinases and phosphatases. FAK pY576/7 was found in all tumors and many cell lines, whereas DDR1 pY792/6 was preferentially enriched in the papillary RCC tumors. Both tyrosine kinases are capable of transmitting signals from the extracellular matrix and emerged as novel RCC therapeutic targets.  Tyrosine kinase profiling informs novel therapeutic strategies in RCC and highlights the unique biology among kidney cancer subtypes.  16. (c)2016 AACR.
Total elbow arthroplasty is moving forward: Review on past, present and future.
Venue: World journal of orthopedics

The elbow joint is a complex joint, which, when impaired in function, leads to severe disability. In some cases however, an arthroplasty might be an appropriate treatment. In the past four decades, large steps have been taken to optimize this treatment in order to achieve better post operative outcomes. To understand these progresses and to discover aspects for upcoming improvements, we present a review on the past developments, the present state of affairs and future developments which may improve patient care further.
The Present and Future of Searching for Dark Matter with LUX and LZ

The LUX collaboration new results advance the search for dark matter candidate particles in the 4 GeV/c^2 and higher mass range, with a maximal spin independent 90% C.L. limit of 2 x 10^ 46 cm^2 at 50 GeV/c^2 for its 332 live day run, following after 6 x 10^ 46 cm^2 cross section for 33 GeV/c^2 mass from the re analysis of its initial 95 live day WIMP search data from December 2015. LUX has performed multiple advanced in situ neutron and beta/gamma calibrations of light and charge yields down to 1.1 and 0.7 keV, respectively, in nuclear recoil energy and 1.3 and 0.2 keV in units of electron recoil energy, thereby bypassing the past practice of extrapolating yields from ex situ calibrations or simulation models alone. For this conference proceedings, consequences of the new calibrations for the limit on the interaction cross sections for low mass WIMPs will be highlighted. Previous claims of a WIMP signal, from other detectors, are now even more strongly disfavored, assuming isospin invariance and the standard WIMP halo model. Both spin independent and spin dependent limits will be discussed, including the recent completion of LUX's 332 live day blind run. Lastly, we highlight the conceptual design and future plan for its 10 ton scale, next generation successor LZ, which plans on achieving 3 x 10^ 48 cm^2 sensitivity for a WIMP of mass 40 GeV/c^2.
User experience in immersive TV A research agenda
Venue: 2016 IEEE International Conference on Image Processing (ICIP)

This paper explores existing theories and models for investigating user experience in the context of Distributed Interactive Multimedia Environments (DIME) in the framework of an immersive TV show developed within ACTION TV project. A descriptive research framework is suggested, which integrates Quality of Service (QoS) Quality of Experience (QoE) and User Experience (UX) to support user centered design and development in DIME. A study, which was conducted during the project and which addresses different aspects of the framework, is presented.
Towards Using Mobile, Head Worn Displays in Cultural Heritage: User Requirements and a Research Agenda
Venue: IUI

Augmented reality (AR) technology has the potential to enrich our daily lives in many aspects. One of them is the museum visit experience. Nowadays, state of the art mobile museum visitor guides provide us with rich personalized, context aware information. However, these systems have one major drawback they force the visitor to hold the guide and to look at its screen. The utilization of smart glasses technology allows providing a wearable AR display without the necessity to hold the guide and to look at it and without distracting the user from the real object. This paper describes initial steps towards the implementation of a head worn display (HWD) museum visitor guide the results of users' requirements elicitation process, the implementation of a first research prototype and initial insights gathered during the process.
Sar graphs: A language resource connecting linguistic knowledge with semantic relations from knowledge graphs
Venue: J. Web Semant.

Recent years have seen a significant growth and increased usage of large scale knowledge resources in both academic research and industry. We can distinguish two main types of knowledge resources: those that store factual information about entities in the form of semantic relations (e.g. Freebase) namely so called knowledge graphs, and those that represent general linguistic knowledge (e.g. WordNet or UWN) In this article, we present a third type of knowledge resource which completes the picture by connecting the two first types. Instances of this resource are graphs of semantically associated relations (sar graphs) whose purpose is to link semantic relations from factual knowledge graphs with their linguistic representations in human language.We present a general method for constructing sar graphs using a language and relation independent, distantly supervised approach which, apart from generic language processing tools, relies solely on the availability of a lexical semantic resource, providing sense information for words, as well as a knowledge base containing seed relation instances. Using these seeds, our method extracts, validates and merges relation specific linguistic patterns from text to create sar graphs. To cope with the noisily labeled data arising in a distantly supervised setting, we propose several automatic pattern confidence estimation strategies, and also show how manual supervision can be used to improve the quality of sar graph instances. We demonstrate the applicability of our method by constructing sar graphs for 25 semantic relations, of which we make a subset publicly available at http:/sargraph.dfki.de.We believe sar graphs will prove to be useful linguistic resources for a wide variety of natural language processing tasks, and in particular for information extraction and knowledge base population. We illustrate their usefulness with experiments in relation extraction and in computer assisted language learning.
Alternative disinfection methods to chlorine for use in the fresh cut industry

The use of chlorine as a disinfectant in the fresh cut produce industry has been identified as a concern mainly due to public health issues. In fact, this chemical, commonly used as hypochlorous acid and hypochlorite, has already been prohibited in some European countries, due to the potential production of toxic by products, such as chloroform and other trihalomethanes, chloramines and haloacetic acids. The search for alternative methods of disinfection is therefore a current and on going challenge in both Academia and Industry. Some methods are well described in the literature on the disinfection of food contact surfaces and process water and also on the decontamination of the produce. These methods are commonly classified as biological (bacteriocins, bacteriophages, enzymes and phytochemicals) chemical (chlorine dioxide, electrolyzed oxidizing water, hydrogen peroxide, ozone, organic acids, etc) and physical (irradiation, filtration, ultrasounds, ultraviolet light, etc) This review provides updated information on the state of art of the available disinfection strategies alternative to chlorine that can be used in the fresh cut industry. The use of combined methods to replace and/or reduce the use of chlorine is also reviewed.
Modelling and Daisy Chaining Control Allocation of a Multirotor Helicopter with a Single Tilting Rotor

This paper presents the development and implementation of a single tilting rotor multirotor helicopter. A single tilting rotor multirotor helicopter is proposed that allows for decoupled lateral acceleration and attitude states. A dynamics model of the proposed multirotor helicopter is established to enable control system development. A control system architecture and daisy chaining based control allocation scheme is developed and implemented. The control architecture facilitates the control of decoupled lateral accelerations and attitudes. Further, a computational and experimental analysis is undertaken and offers evidence that the proposed multirotor helicopter and control system architecture enables the multirotor helicopter to achieve lateral accelerations without requiring attitude actuation.
Styles interactifs des parents teko, aluku, haitiens et laotiens une etude comparative de groupes minoritaires guyanais

L'article presente les resultats d'une recherche s'interessant a l'identification des pratiques educatives parentales quotidiennes des 16 dyades parent enfant appartenant a quatre groupes minoritaires (deux groupes d'immigres et deux groupes d'autochtones) vivant en Guyane francaise. Le recueil des donnees a ete fait par des observations in situ. Une typologie des conduites parentales a ete proposee en se basant sur une grille des categories comportementales inspiree de nos precedents travaux. Les analyses ont mis en evidence des conduites parentales contrastees entre les groupes socioculturels observes, bien que des similitudes aient ete relevees. La variabilite interactive inter groupes conforte l'hypothese du lien entre l'education familiale et l'adaptabilite scolaire de l'enfant. La prise en compte de ces resultats dans la formation des maitres de Guyane permettrait aux professeurs stagiaires une approche positive, basee sur les contextes situationnels objectifs du quotidien de l'enfant, sans les rapporter a une norme implicite.
Etude de validation du programme Funambule pour une gestion equilibree du stress des adolescents

C'est dans une optique de prevention primaire de l'influence potentiellement nefaste du stress sur les taches developpementales des adolescents qu'un programme de type universel, Funambule pour une gestion equilibree du stress, a ete cree puis evalue selon un devis quasi experimental (Dumont, en collaboration avec Masse, Potvin et Leclerc, 2012) Au total, 138 adolescents quebecois ages de 14 a 19 ans ont ete apparies, dans les groupes experimentaux et temoins, selon le genre et le niveau de stress ressenti (Problemes dans divers secteurs de vie; Seiffge Krenke, 2005) Les effets du programme ont ete evalues au moyen du Questionnaire des strategies de gestion du stress (Dumont, Masse, Leclerc et Potvin, 2007) de l'Inventaire de resolution de problemes sociaux (Maydeu Olivares et D'Zurilla, 1996) et de l'Echelle d'anxiete en contexte de performance (Cassady et Johnson, 2002) Comme prevu, des effets benefiques ont ete observes entre le pretest et le post test dans le groupe experimental, ce qui n'a pas ete le cas dans le groupe temoin. Les resultats indiquent une amelioration significative de la gestion du stress pour trois des quatre volets de Funambule, a savoir le travail sur la perception du stress, le corps et les pensees. Une amelioration significative de la capacite rationnelle a resoudre des problemes ainsi qu'une diminution significative de l'anxiete aux evaluations pour les eleves du groupe experimental ont egalement ete observees.
Learning API Usages from Bytecode: A Statistical Approach
Venue: 2016 IEEE/ACM 38th International Conference on Software Engineering (ICSE)

Mobile app developers rely heavily on standard API frameworks and libraries. However, learning API usages is often challenging due to the fast changing nature of API frameworks for mobile systems and the insufficiency of API documentation and source code examples. In this paper, we propose a novel approach to learn API usages from bytecode of Android mobile apps. Our core contributions include HAPI, a statistical model of API usages and three algorithms to extract method call sequences from apps' bytecode, to train HAPI based on those sequences, and to recommend method calls in code completion using the trained HAPIs. Our empirical evaluation shows that our prototype tool can effectively learn API usages from 200 thousand apps containing 350 million method sequences. It recommends next method calls with top 3 accuracy of 90% and outperforms baseline approaches on average 10 20%
Dynamic assessment of forest resources quality at the provincial level using AHP and cluster analysis
Venue: Comput. Electron. Agric.

AHP and cluster analysis were integrated to assess the forest resources quality (FQR).Ecological projects have significantly improved the FRQ at provincial and national levels.During 2009 2013, the numbers of provinces scoring at excellent, medium, inferior level were 3, 15, 12 and 1.Forest resources in the 31 provinces during 2009 2013 were grouped into four clusters.The findings provide theoretical and technical references for forest management in China. The aim of this study was to quantitatively assess and analyze the dynamic changes and current problems of Chinese forest resources based on the National Forest Inventory (NFI) In this study, a hierarchical model was established using the analytic hierarchy process to assess forest resources quality (FRQ) at the provincial level. Four criteria were used, including forest quantity, forest productivity, forest structure, and forest health and each criterion was further composed of multiple factors. Among these assessment factors, stock volume per unit area was the most important, while canopy structure was the least important. The ranges of FRQ Indies across China during the 6th NFI (1999 2003) 7th NFI (2004 2008) and 8th NFI (2009 2013) were 0.3031 0.6366, 0.3499 0.7186, and 0.3534 0.7555, respectively. From the 6th to 8th NFI, forest quality improved by different degrees for all provinces, whereas the other three criteria presented an increasing or decreasing trend. In general, the implementation of ecological projects has significantly improved the FRQ at provincial and national levels. During the 8th NFI, the FRQ levels were excellent for 3 provinces, good for 15 provinces, medium for 12 provinces, and only one province exhibited an inferior level of FRQ. Based on cluster analysis, Chinese forest resources during the 8th NFI could be grouped into four clusters according to the provincial administrative region, and each cluster had its own advantages and disadvantages. Stock volume increment and forest calamity were in a very good state, while canopy structure was the key factor limiting the FQR for all the clusters. Some relevant measures were proposed to improve the existing conditions of Chinese forest resources. The results of this study are significant in that they can provide theoretical and technical references for future adjustment and sustainable management of forest resources in China.
PHIDIAS: ultra low power holistic design for smart bio signals computing platforms
Venue: Conf. Computing Frontiers

Emerging and future HealthCare policies are fueling up an application driven shift toward long term monitoring of biosignals by means of embedded ultra low power Wireless Body Sensor Networks (WBSNs) In order to break out, these applications needed the emergence of new technologies to allow the development of extremely power efficient bio sensing nodes. The PHIDIAS project aims at unlocking the development of ultra low power bio sensing WBSNs by tackling multiple and interlocking technological breakthroughs: (i) the development of new signal processing models and methods based on the recently proposed Compressive Sampling paradigm, which allows the design of energy minimal computational architectures and analog front ends, (ii) the efficient hardware implementation of components, both analog and digital, building upon an innovative ultra low power signal processing front end, (iii) the evaluation of the global power reduction using a system wide integration of hardware and software components focused on compressed sensing based bio signals analysis. PHIDIAS brought together a mixed consortium of academic and industrial research partners representing pan European excellence in different fields impacting the energy aware optimization of WBSNs, including experts in signal processing and digital/analog IC design. In this way, PHIDIAS pioneered a unique holistic approach, ensuring that key breakthroughs worked out in a cooperative way toward the global objective of the project.
[Acute toxicity study of Aspidopterys obcordata aqueous extract in Sprague Dawley rats]

To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata (A. obcordata) in Sprague Dawley rats.  The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured. After 14 days, the rats were sacrificed and their organs (liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology (e.g. hemoglobin and white blood cell counts) and clinical blood biochemistry (e.g. albumin and bilirubin) were also examined.  There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity (LD50) was estimated to be 5000 mg/kg body weight.  Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long term toxicity testing of A. obcordata is warranted.
[Acute toxicity study of Aspidopterys obcordata aqueous extract in Sprague Dawley rats]
Venue: Journal of traditional Chinese medicine Chung i tsa chih ying wen pan

To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata (A. obcordata) in Sprague Dawley rats.  The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured. After 14 days, the rats were sacrificed and their organs (liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology (e.g. hemoglobin and white blood cell counts) and clinical blood biochemistry (e.g. albumin and bilirubin) were also examined.  There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity (LD50) was estimated to be 5000 mg/kg body weight.  Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long term toxicity testing of A. obcordata is warranted.
Patient Care Sitter Reduction and Fall Safety Improvement

The financial constraints imposed upon operational budgets by the frequent use of patient care sitters is well known among hospital leadership. Despite the high labor costs associated with direct and continuous observation, this intervention is routinely deployed by frontline care teams in an effort to preserve patients from harm, particularly from accidental falls. This reality creates an opportunity where significant budget savings can be achieved by supplanting the use of patient care sitters with more effective fall prevention strategies. This quality improvement (QI) project implemented a non psychiatric sitter reduction and fall prevention initiative in two high volume adult acute care units. Through a collaborative process involving frontline staff, clinical subject matter experts, leadership stakeholders, and medical equipment vendor support, this project implemented a three fold quality improvement effort including education, policy enhancement, and patient safety supply evaluation. This multi tier engagement included a 60day clinical evaluation of the program elements where sitter utilization, fall events, and falls with injury were compared to the organization's historical performance. The project produced a 46% reduction in sitter utilization within the two trial units. Though fall outcomes were unaffected by this QI project, the initiative produced results commensurate with contemporary evidence that utilization of patient care sitters can be effectively reduced without risk to patient safety.
Archie's law a reappraisal

When scientists apply Archie's first law they often include an extra parameter a, which was introduced about 10 years after the equation's first publication by Winsauer et al. (1952) and which is sometimes called the "tortuosity" or "lithology" parameter. This parameter is not, however, theoretically justified. Paradoxically, the Winsauer et al. (1952) form of Archie's law often performs better than the original, more theoretically correct version. The difference in the cementation exponent calculated from these two forms of Archie's law is important, and can lead to a misestimation of reserves by at least 20 for typical reservoir parameter values. We have examined the apparent paradox, and conclude that while the theoretical form of the law is correct, the data that we have been analysing with Archie's law have been in error. There are at least three types of systematic error that are present in most measurements: (i) a porosity error, (ii) a pore fluid salinity error, and (iii) a temperature error. Each of these systematic errors is sufficient to ensure that a non unity value of the parameter a is required in order to fit the electrical data well. Fortunately, the inclusion of this parameter in the fit has compensated for the presence of the systematic errors in the electrical and porosity data, leading to a value of cementation exponent that is correct. The exceptions are those cementation exponents that have been calculated for individual core plugs. We make a number of recommendations for reducing the systematic errors that contribute to the problem and suggest that the value of the parameter a may now be used as an indication of data quality.