nils-herrmann/clean_scirepeval huggingface dataset:
Video alignment for phylogenetic analysis
Venue: 2016 24th European Signal Processing Conference (EUSIPCO)

The possibility of studying multiple objects at once for forensic analysis has paved the way to the development of multimedia phylogeny algorithms. Concerning video phylogeny, a fundamental step at the base of many applications is multiple video alignment. This is, given a pool of near duplicate video sequences partially overlapping in the temporal domain, find the relative time delay between all of them. As phylogeny methods typically takes into account huge quantities of data, the used alignment algorithms must be computationally efficient. In this paper, we propose a solution for multiple video alignment based on the minimisation of a least square cost function. The proposed solution can be computed in closed form with reduced computational complexity. Moreover, we propose two possible solutions for refining the estimated alignment based on the removal of outlier measurements.
Engineering Stem Cell Organoids.
Venue: Cell stem cell

Organoid systems leverage the self organizing properties of stem cells to create diverse multi cellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell cell/cell matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell based organoids, their advantages and limitations, and how bioengineering strategies can be used to steer the cell composition and their 3D organization within organoids to further enhance their utility in research and therapies.
A Capability Based View of Brand Management

Brands are assets that are intangible in nature. This provides companies with the potential to extract higher rents or prices from customers (Keller and Lehmann 2006) Key to building strong brands lies in the way firms manage their brands. This capability called brand management includes all the activities that firms undertake to develop and maintain brands (Low and Fullerton 1994) Brand managers are the ones who manage brands and hence become an important resource in developing brands. Brand management capability has developed from being an administrative function to a more strategic function (Rust et al. 2004; Low and Fullerton 1994) Merz et al. (2009) trace the development of brand management originating from individual goods focus (Copeland 1923; Low and Fullerton 1994) to value focus (Park et al. 1986) relationship focus (Aaker 1992; Keller 1993) and finally toward stakeholder focus. Relying on the knowledge or capability based perspective (Barreto 2010; Cohen and Levinthal 1990; Helfat and Petraf 2009; Kogut 1988; Levinthal and March 1993) we argue that for effective brand management firms need to have certain capabilities and knowledge. The brand management capability of an organization is an operant resource (Vargo and Lusch 2004, 2008) which enables an organization to achieve competitive advantage (Grant 1996; Hunt and Morgan 1995; Challagalla et al. 2014) by creating strong brands. This capability and knowledge is an idiosyncratic and unique resource which is hard to imitate (Barney 1991) since it is a combination of several organizational and personnel characteristics. However, despite its importance, few studies have explored the antecedents of brand management capability within an organization. Using Complex Adaptive System Perspective (Grant 2003; Arikan 2010; Paswan and Tran 2012) we argue that brand management capability is developed through the interactions between the senior management, other internal managers, external stakeholders such as advertising agency and channel personnel, external environmental factors, and brand managers. The importance of this study is highlighted by the fact that marketing function, especially brand management, has come under a lot of criticism for the lack of objective financial measures to determine its value (Nath and Mahajan 2011; Srivastava et al. 1998) With increasing importance of brands and brand management (Keller and Lehmann 2006; De Chernatony and Cottam 2009, Cui et al. 2014) it is imperative to identify factors that facilitate the creation and management of strong brands. Finally, this study contributes to the increasing calls to view brand management function as an application of knowledge, contributing to the viewpoint of marketing resources being dynamic capabilities (Day 2014; Kozlenkova et al. 2014) The proposed framework will help firms that are lagging in one or more of the dimensions of brand management capability (i.e. organizational, human, or relational)
Effects of diabetes drugs on the skeleton.
Venue: Bone

Type 2 diabetes is associated with increased fracture risk and the mechanisms underlying the detrimental effects of diabetes on skeletal health are only partially understood. Antidiabetic drugs are indispensable for glycemic control in most type 2 diabetics, however, they may, at least in part, modulate fracture risk in exposed patients. Preclinical and clinical data clearly demonstrate an unfavorable effect of thiazolidinediones on the skeleton with impaired osteoblast function and activated osteoclastogenesis. The negative effect of thiazolidinediones on osteoblastogenesis includes decreased activity of osteoblast specific transcription factors (e.g. Runx2, Dlx5, osterix) and decreased activity of osteoblast specific signaling pathways (e.g. Wnt, TGF b/BMP, IGF 1) In contrast, metformin has a positive effect on osteoblast differentiation due to increased activity of Runx2 via the AMPK/USF 1/SHP regulatory cascade resulting in a neutral or potentially protective effect on bone. Recently marketed antidiabetic drugs include incretin based therapies (GLP 1 receptor agonists, DPP 4 inhibitors) and sodium glucose co transporter 2 (SGLT2) inhibitors. Preclinical studies indicate that incretins (GIP, GLP 1, and GLP 2) play an important role in the regulation of bone turnover. Clinical safety data are limited, however, meta analyses of trials investigating the glycemic lowering effect of both, GLP 1 receptor agonists and DPP4 inhibitors, suggest a neutral effect of incretin based therapies on fracture risk. For SGLT2 inhibitors recent data indicate that due to their mode of action they may alter calcium and phosphate homeostasis (secondary hyperparathyroidism induced by increased phosphate reabsorption) and thereby potentially affect bone mass and fracture risk. Clinical studies are needed to elucidate the effect of SGLT2 inhibitors on bone metabolism. Meanwhile SGLT2 inhibitors should be used with caution in patients with high fracture risk, which is specifically true for the use of thiazolidinediones.
Notch Signaling and the Skeleton.
Venue: Endocrine reviews

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch signaling plays an important role in skeletal development and bone remodeling. After direct interactions with ligands of the Jagged and Delta like families, a series of cleavages release the Notch intracellular domain (NICD) which translocates to the nucleus where it induces transcription of Notch target genes. Classic gene targets of Notch are hairy and enhancer of split (Hes) and Hes related with YRPW motif (Hey) In cells of the osteoblastic lineage, Notch activation inhibits cell differentiation and causes cancellous bone osteopenia because of impaired bone formation. In osteocytes, Notch1 has distinct effects that result in an inhibition of bone resorption secondary to an induction of osteoprotegerin and suppression of sclerostin with a consequent enhancement of Wnt signaling. Notch1 inhibits, whereas Notch2 enhances, osteoclastogenesis and bone resorption. Congenital disorders of loss and gain of Notch function present with severe clinical manifestations, often affecting the skeleton. Enhanced Notch signaling is associated with osteosarcoma, and Notch can influence the invasive potential of carcinoma of the breast and prostate. Notch signaling can be controlled by the use of inhibitors of Notch activation, small peptides that interfere with the formation of a transcriptional complex, or antibodies to the extracellular domain of specific Notch receptors or to Notch ligands. In conclusion, Notch plays a critical role in skeletal development and homeostasis, and serious skeletal disorders can be attributed to alterations in Notch signaling.
Mechanobiology of TGFb signaling in the skeleton.
Venue: Matrix biology journal of the International Society for Matrix Biology

Physical and biochemical cues play fundamental roles in the skeleton at both the tissue and cellular levels. The precise coordination of these cues is essential for skeletal development and homeostasis, and disruption of this coordination can drive disease progression. The growth factor TGFb is involved in both the regulation of and cellular response to the physical microenvironment. It is essential to summarize the current findings regarding the mechanisms by which skeletal cells integrate physical and biochemical cues so that we can identify and address remaining gaps that could ultimately improve skeletal health. In this review, we describe the role of TGFb in mechanobiological signaling in bone and cartilage at the tissue and cellular levels. We provide detail on how static and dynamic physical cues at the macro level are transmitted to the micro level, ultimately leading to regulation at each level of the TGFb pathway and to cell differentiation. The continued integration of engineering and biological approaches is needed to answer many remaining questions, such as the mechanisms by which cells generate a coordinated response to physical and biochemical cues. We propose one such mechanism, through which the combination of TGFb and an optimal physical microenvironment leads to synergistic induction of downstream TGFb signaling.
KARAKTERISTIK HIDROLISAT PROTEIN IKAN BANDENG (Chanos chanos Forsk) DENGAN KONSENTRASI ENZIM BROMELIN YANG BERBEDA Caracteristic of Milkfish (Chanos chanos Forsk) Protein Hydrolysate as effect of Different Bromelin Enzyme Concentration

Ikan Bandeng berpotensi menjadi bahan baku hidrolisat protein ikan karena kandungan protein tinggi dan potensi produksi cukup melimpah. Enzim Bromelin merupakan salah satu enzim protease yang dapat membantu dalam mempercepat reaksi hidrolisa protein. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi enzim bromelin terhadap kualitas hidrolisat protein Ikan Bandeng (C hanos chanos Forks) segar. Rancangan percobaan yang digunakan pada penelitian ini adalah rancangan acak lengkap dengan perlakuan konsentrasi enzim yang berbeda (4% 5% dan 6% Parameter yang diamati adalah nilai kadar protein, lemak, air, karbohidrat, serat kasar dan rendemen. Konsenterasi enzim bromelin berpengaruh nyata pada nilai kadar protein, lemak, air, abu, serat kasar dan rendemen (P 0,05) Kondisi optimum untuk menghidrolisis daging Ikan Bandeng menjadi hidrolisat protein adalah konsentrasi enzim bromelin 6% dengan waktu hidrolisis selama 6 jam. Kata kunci Ikan Bandeng Chanos chanos hidrolisat protein ikan, enzim bromelin ABSTRACT Milkfish is potentially become the raw material of fish protein hydrolyzate because of the high protein content and relatively abundant production. Bromelin is a protease enzyme that can help on improving protein hydrolyzate quality. This research aimed to determine the effect of bromelain enzyme concentration on the quality of the protein hydrolyzate of milkfish Chanos chanos Forsk) fresh. The experimental design used in this study was completely randomized design with different concentrations of the enzyme (4% 5% and 6% as a treatment. The parameters measured were the contents of protein, fat, water, carbohydrates, crude fiber and yield. The concentration of enzyme bromelin significant effect on contents of protein, fat, water, ash, crude fiber and yield (P 0,05) The optimum conditions to hydrolyze the milkfish meat into a protein hydrolyzate used 6% bromelin enzyme at the time of hydrolysis for 6 hours.  Milkfish (Chanos chanos) fish protein hydrolisate, bromelin enzym
The Myth of Europe in Art and European Identities. The Divided Memory of Europe Will Europe Succumb to Disintegration

beata.di.biasio@gmail.com Bohdan MICHALSKI The Aleksander Zelwerowicz National Academy of Dramatic Art in Warsaw e mail: michalski.bohdan@gmail.com THE MYTH OF EUROPE IN ART AND EUROPEAN IDENTITIES1 THE DIVIDED MEMORY OF EUROPE WILL EUROPE SUCCUMB TO DISINTEGRATION? The Polish government commissioned from Franciszek Starowieyski, a renowned Polish painter, a composition to embellish the new building of the Permanent Representation of the Republic of Poland at the European Union in Brussels. The monumental Divina Polonia rapta per Europa profana, executed in 1998, was put on permanent show in the main hall of the Permanent Representation seat. 'Divina Polonia, the second female figure featured in the canvas next to Europe, is depicted with a halo. F. Starowieyski referred to the classical myth of Europe (a Phoenician princess abducted by Zeus disguised as a bull) in order to emphasize the contrast between secular Europe and 'holy' Poland. What is the source of this combination of nudity and saintliness? Why has this otherwise liberated artist, who in hundreds of compositions obsessively portrays the female nude and remains distant from bigotry or clericalism, suddenly resorted to religious symbols? These intriguing and disturbing questions arose after seeing the exhibition on the myth of Europe shown in Florence. There, works of twentiethcentury artists from Western Europe did not contain religious symbols. We seem to be approaching the topical problem of the unity of Europe. The canvas Divina 1 The article uses some analyses contained in the Ph.D. dissertation by Beata di Biasio: The Myth of Europe in Polish Artistic Culture and Painting of the Twentieth Century (2006) 102 Politeja 5(44)/2016 Beata Klocek Di Biasio, Bohdan Michalski Polonia rapta per Europa profana is a symbolic summary of the two different historical experiences of the East and West of Europe.
Impact of the HITECH Act on physicians' adoption of electronic health records
Venue: J. Am. Medical Informatics Assoc.

The Health Information Technology for Economic and Clinical Health (HITECH) Act has distributed billions of dollars to physicians as incentives for adopting certified electronic health records (EHRs) through the meaningful use (MU) program ultimately aimed at improving healthcare outcomes. The authors examine the extent to which the MU program impacted the EHR adoption curve that existed prior to the Act.  Bass and Gamma Shifted Gompertz (G/SG) diffusion models of the adoption of "Any" and "Basic" EHR systems in physicians' offices using consistent data series covering 2001 2013 and 2006 2013, respectively, are estimated to determine if adoption was stimulated during either a PrePay (2009 2010) period of subsidy anticipation or a PostPay (2011 2013) period when payments were actually made.  Adoption of Any EHR system may have increased by as much as 7 percentage points above the level predicted in the absence of the MU subsidies. This estimate, however, lacks statistical significance and becomes smaller or negative under alternative model specifications. No substantial effects are found for Basic systems. The models suggest that adoption was largely driven by "imitation" effects (q coefficient) as physicians mimic their peers' technology use or respond to mandates. Small and often insignificant "innovation" effects (p coefficient) are found suggesting little enthusiasm by physicians who are leaders in technology adoption.  The authors find weak evidence of the impact of the MU program on EHR uptake. This is consistent with reports that many current EHR systems reduce physician productivity, lack data sharing capabilities, and need to incorporate other key interoperability features (e.g. application program interfaces)
Determination of rare earth elements in natural water samples A review of sample separation, preconcentration and direct methodologies.
Venue: Analytica chimica acta

This review discusses and compares the methods given for the determination of rare earth elements (REE) in natural water samples, including sea, river, lake, tap, ground and waste waters as well as Antarctic ice. Since REE are at very low concentrations in natural waters, numerous different preconcentration methods have been proposed to enable their measurement. These include liquid liquid extraction, dispersive liquid liquid micro extraction and solidified floating drop micro extraction. In addition to liquid liquid extraction methods, solid phase extraction using commercial resins, resins made in house, silica based exchange materials and other solid media is also discussed. These and other techniques such as precipitation/co precipitation and flotation are compared in terms of speed, preconcentration factors achieved, precision, accuracy and limits of detection (LOD) Some papers have discussed the direct determination of REE in these sample types. Some have used specialised sample introduction systems such as ultrasonic nebulization whereas others have used a standard sample introduction system coupled with inductively coupled plasma mass spectrometry (ICP MS) detection. These direct methods have also been discussed and compared.
Microwave Assisted Synthesis of Solid Epoxy Resins: Study of Molecular Weight by GPC and MALDI TOF/MS

A new method of preparation of solid epoxy resins (SER) with desired epoxy group content via an advanced process under microwave irradiation is presented together with the results of molecular weight measurements for narrow oligomeric fractions obtained from chromatographic separation of SER. All the measurements were performed using gel permeation chromatography (GPC) and matrix assisted laser desorption ionization spectrometry time of flight mass spectrometry (MALDI TOF/MS) In the GPC analysis, two types of calibration were used: the first was a standard calibration based on polystyrene standards, while the second was done on the basis of a chromatograms of epoxy resins synthesized from bisphenol A (BPA) and diglycidyl ether of bisphenol A (EDBPA) On the basis of the MALDI TOF analysis, it was assumed that the purity of starting materials, i.e. low molecular weight epoxy resin, clearly determined the structure of the SER. In order to obtain an SER with linear chain structures and an even number of po.
Homogeneous Charge Compression Ignition (HCCI) Engines: A Review

The homogeneous charge compression ignition (HCCI) combustion is considered to be the principally promising future IC engine concepts. HCCI is a concept of hybrid combustion, between the Otto engine and Diesel engine. HCCI is however not a modern finding. Already in the early twentieth century hot bulb engines operated with an HCCI like combustion. They were superior in terms of brake efficiency compared with the contemporary gasoline engines and at the same level as the diesel engines. High engine efficiencies and ultra low NO emissions and low particulates are the benefits of HCCI engines. Volumetric auto ignited combustion of the compressed lean air fuel mixture is attributed to these benefits. There are few drawbacks also were there in HCCI engines like, low specific output, narrow operating range, lack control over the ignition process, long start up time and high emissions like CO and UHC emissions. The CO and UHC emissions can be after treated using catalytic converters. In this study a literature review on HCCI engine has been performed and the parameters affecting the HCCI combustion phasing, performance and emissions were discussed. Strategies to widen the peak load bearing capacity of HCCI engine, reducing the emissions like NOx, CO and UHC, easy auto ignition were discussed in the present study.
Les reseaux de personnages de science fiction echantillons de lectures intermediaires

Cette recherche propose la lecture d'oeuvres de science fiction avec l'assistance de methodes mathematiques issues de la theorie des graphes. Notre approche associe lecture serree et lecture distante pour representer les liaisons entre les personnages, a partir de la structure formee par leurs co occurrences dans le texte. Ce travail comporte trois propositions principales. La premiere est l'introduction d'une methode de lecture intermediaire (ou middle reading alliant lecture serree et lecture distante pour fournir une analyse du systeme des personnages d'une oeuvre de fiction. Elle recourt a la visualisation de reseaux et a l'exploitation de leurs proprietes mathematiques (centralites, formations de communautes) La deuxieme proposition est une typologie d'oeuvres basee sur la structure formee par leurs personnages. La derniere proposition est un essai de lecture des oeuvres basee sur la qualification des personnages, a fin d'etude des representations.
Current Gender Trends in Belarusian Labor Market: Wage Gap, Child Penalty and Marriage Premium

The issue of gender equality in Belarus labor market is still unclear. On the one hand the rate of female participation is high. At the same time there is evidence of the rising gender pay gap that grew from 16.5% in 2005 to 24% in 2014. The decomposition of the wage gap during 2005 2014 time period using Oaxaca Blinder, Juhn Murphy Pierce and Machado Mata techniques revealed that differences in income function (the difference in a way efforts of men and women are remunerated) are the main factors affecting the growth of gender inequality, while the personal characteristics are losing the influencing power. The role of the factors differs depending on the quantile of income distribution. I also find no association between wages and marriage for females, while there is a 10.5% wage premium in case of married males. The parenthood wage penalty is attributed to women and equals approximately 14.4% Moreover, children from 0 to 6 provide the most severe drop in wages. In addition, the paper reveals that educated women are suffering the most and face 20.4% decline in wages, while penalty for women with the secondary school or lower amounts to just 8%
Use of the Flory Huggins theory to predict the solubility of nifedipine and sulfamethoxazole in the triblock, graft copolymer Soluplus
Venue: Drug development and industrial pharmacy

Drug dispersed in a polymer can improve bioavailability; dispersed amorphous drug undergoes recrystallization. Solid solutions eliminate amorphous regions, but require a measure of the solubility.  Use the Flory Huggins Theory to predict crystalline drugs solubility in the triblock, graft copolymer Soluplus(r) to provide a solid solution.  Physical mixtures of the two drugs with similar melting points but different glass forming ability, sulfamethoxazole and nifedipine, were prepared with Soluplus(r) using a quick technique. Drug melting point depression (MPD) was measured using differential scanning calorimetry. The Flory Huggins Theory allowed: (1) interaction parameter, kh, calculation using MPD data to provide a measure of drug polymer interaction strength and (2) estimation of the free energy of mixing. A phase diagram was constructed with the MPD data and glass transition temperature (Tg) curves.  The interaction parameters with Soluplus(r) and the free energy of mixing were estimated. Drug solubility was calculated by the intersection of solubility equations and that of MPD and Tg curves in the phase diagram.  Negative interaction parameters indicated strong drug polymer interactions. The phase diagram and solubility equations provided comparable solubility estimates for each drug in Soluplus(r) Results using the onset of melting rather than the end of melting support the use of the onset of melting.  The Flory Huggins Theory indicates that Soluplus(r) interacts effectively with each drug, making solid solution formation feasible. The predicted solubility of the drugs in Soluplus(r) compared favorably across the methods and supports the use of the onset of melting.