nils-herrmann/clean_scirepeval huggingface dataset:
Maternal plasma PUFA concentrations during pregnancy and childhood adiposity: the Generation R Study.
Venue: The American journal of clinical nutrition

Maternal polyunsaturated fatty acid (PUFA) concentrations during pregnancy may have persistent effects on growth and adiposity in the offspring. A suboptimal maternal diet during pregnancy might lead to fetal cardiometabolic adaptations with persistent consequences in the offspring.  We examined the associations of maternal PUFA concentrations during pregnancy with childhood general and abdominal fat distribution measures.  In a population based, prospective cohort study of 4830 mothers and their children, we measured maternal second trimester plasma n 3 (o 3) and n 6 (o 6) PUFA concentrations. At the median age of 6.0 y (95% range: 5.6, 7.9 y) we measured childhood body mass index (BMI) the fat mass percentage, and the android:gynoid fat ratio with the use of dual energy X ray absorptiometry and measured the preperitoneal abdominal fat area with the use of ultrasound. Analyses were adjusted for maternal and childhood sociodemographic and lifestyle related characteristics.  We observed that higher maternal total n 3 PUFA concentrations, and specifically those of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid, were associated with a lower childhood total body fat percentage and a lower android:gynoid fat mass ratio (P< 0.05) but not with childhood BMI and the abdominal preperitoneal fat mass area. Higher maternal total n 6 PUFA concentrations, and specifically those of dihomo g linolenic acid, were associated with a higher childhood total body fat percentage, android:gynoid fat mass ratio, and abdominal preperitoneal fat mass area (P< 0.05) but not with childhood BMI. In line with these findings, a higher maternal n 6:n 3 PUFA ratio was associated with higher childhood total body and abdominal fat mass.  Lower maternal n 3 PUFA concentrations and higher n 6 PUFA concentrations during pregnancy are associated with higher body fat and abdominal fat in childhood. Additional studies are needed to replicate these observations and to explore the causality, the underlying pathways, and the long term cardiometabolic consequences.
Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia.
Venue: The Journal of allergy and clinical immunology

In patients with severe eosinophilic asthma, local maturation rather than systemic recruitment of mature cells might contribute to persistent airway eosinophilia. Group 2 innate lymphoid cells (ILC2s) are a major source of type 2 cytokines (IL 5 and IL 13) and can facilitate eosinophilic inflammatory responses in mouse models of asthma in the absence of CD4+ lymphocytes. This study investigated the potential role of ILC2s in driving chronic airway eosinophilia in patients with severe asthma, despite regular high dose oral corticosteroid therapy.  In a cross sectional study we enumerated blood and sputum ILC2s (lin( )CD45()127()ST2( and levels of intracellular IL 5 and IL 13 in patients with severe asthma (n 25) patients with steroid naive mild atopic asthma (n 19) and nonatopic control subjects (n 5) Results were compared with numbers of CD4+ lymphocytes, eosinophil lineage committed progenitors (eosinophilopoietic progenitor cells [EoPs] and mature eosinophils.  Significantly greater numbers of total and type 2 cytokine producing ILC2s were detected in blood and sputum of patients with severe asthma compared to mild asthmatics. In contrast, intracellular cytokine expression by CD4 cells and EoPs within the airways did not differ between the asthmatic groups. In patients with severe asthma, although sputum CD4+ cells were more abundant than ILC2s and EoPs, proportionally, ILC2s were the predominant source of type 2 cytokines. In addition, there were significantly greater numbers of sputum IL 5()IL 13( ILC2s in patients with severe asthma whose airway eosinophilia was greater than 3% despite normal blood eosinophil numbers <300/mL)  Our findings suggest that ILC2s can promote the persistence of airway eosinophilia in patients with severe asthma through uncontrolled localized production of the type 2 cytokines IL 5 and IL 13, despite high dose oral corticosteroid therapy.
Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease
Venue: Therapeutic advances in chronic disease

The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD) are common affecting over 500 million people worldwide and causing substantial morbidity and mortality. Asthma is typically associated with Th2 mediated eosinophilic airway inflammation, in contrast to neutrophilic inflammation observed commonly in COPD. However, there is increasing evidence that the eosinophil might play an important role in 10 40% of patients with COPD. Consistently in both asthma and COPD a sputum eosinophilia is associated with a good response to corticosteroid therapy and tailored strategies aimed to normalize sputum eosinophils reduce exacerbation frequency and severity. Advances in our understanding of the multistep paradigm of eosinophil recruitment to the airway, and the consequence of eosinophilic inflammation, has led to the development of new therapies to target these molecular pathways. In this article we discuss the mechanisms of eosinophilic trafficking, the tools to assess eosinophilic airway inflammation in asthma and COPD during stable disease and exacerbations and review current and novel anti eosinophilic treatments.
Expression of inflammation related genes in the lung of BALB/c mice response to H7N9 influenza A virus with different pathogenicity
Venue: Medical Microbiology and Immunology

H7N9 influenza A virus (IAV) infected human cases are increasing and reported over 200 mortalities since its first emergence in 2013. Host inflammatory response contributes to the clearance of influenza virus; meanwhile, the induced "cytokine storm" also leads to pathological lesions. However, what inflammation related response of the host for H7N9 influenza A virus infection to survival from injures of exuberant cytokine release is still obscure. In this research, expression pattern and histological distribution of inflammation related genes, RIP3, NLRP3, IL 1b, TNF a, Slit2 and Robo4 in the lung of BALB/c mice infected with two H7N9 IAV strains with only a PB2 residue 627 difference were investigated, as well as the histopathological injury of the lung. Results showed that significantly higher expression level of NLRP3, RIP3, IL 1b and TNF a in H7N9 infected groups compared with the control would play a key role in driving lung pathological lesion. While the expression level of Slit2 and Robo4 in H7N9 rVK627E group had significantly increased trend than VK627 which might be the main factor to inhibit the interstitial pneumonia and infiltration. Also, H7N9 induced the histopathological changes in the lung of infected mice, and RIP3, NLRP3, IL 1b, TNF a, Slit2 and Robo4 showed cell specific distribution in the lung. The results will provide basic data for further research on the mechanism of inflammatory response and understanding of the role of site 627 in PB2 in H7N9 IAVs infection. In addition, enhancing the resilience of the host vascular system to the inflammatory response by regulation of Slit2 Robo4 signaling pathway might provide a novel strategy for H7N9 IAVs infection.
Low Overhead and High Precision Prediction Model for Content Based Sensor Search in the Internet of Things
Venue: IEEE Communications Letters

A growing number of Internet connected sensors have already promoted the advance of sensor search service. Accessing all available objects to find the sought sensor results in huge communication overhead, thus a low overhead and high precision prediction model (LHPM) is proposed to improve the sensor search efficiency. We design the approximation method to lower the reporting energy cost. Then a multistep prediction method is proposed to accurately estimate the sensor state. Furthermore, a sensor ranking method is presented to assess the matching probabilities of sensors, so as to effectively reduce the communication overhead of the search process. Simulation results demonstrate the validity of the proposed prediction model in the area of content based sensor search.
The Posthuman that Could Have Been: Mary Shelley's Creature

At the very core of Mary Shelley's Frankenstein, the Creature meets his maker, acquaints him and, consequently, the reader with the narrative of his miserable life, and entreats him to make a female companion with whom he can share his life. Although Victor admits to having been moved by the Creature's eloquence and fine sensations, he reluctantly succumbs to his plea only to destroy the female before completing her, afraid that this new species might pose a threat to the survival of his own. In the encounter of these two species, however, only one seems to have truly "met" the other: the Creature has indeed become with his maker in a way that Victor fails. Given that the dominant narrative point of view up until that moment had been Victor's, readers of the novel have the opportunity of having their ignorance enriched regarding the Creature straight from the Other's mouth, this multiple narrative thus enabling them to take Victor's creation as far more than the monster he sees. Indeed, I would argue that readers do "meet" the Creature while his creator cannot. Taking this central part of the novel as a starting point, this essay will explore the coexistence of transhuman and posthuman discourses in Mary Shelley's Frankenstein, working mainly with the 1818 text. In expressing his desire to create an improved species, rendering "man invulnerable to any but a violent death" Victor echoes the transhuman discourses of improvement of the human race, while remaining of this transitory stage, unable to make the transition to the posthuman phase which would grant humanness to his Creature, irrespective of his appearance. In failing to do so, I will explore whether he is also preventing the Creature to become truly posthuman.
"Modeling aspects of human trails on the web" by Philipp Singer, with Prateek Jain as coordinator
Venue: LINK

Philipp Singer is a now post doctoral researcher at the Computational Social Science Department of GESIS in Cologne. In the last few years, his research has focused on modeling aspects of human sequences on the Web. To that end, he has been dedicated to provide insights and tools that facilitate future research concerned with the study of regularities, patterns and strategies in human sequences on the Web. Philipp has published in several renowned conferences and journals such as WWW, CIKM, ISWC, IJSWIS or EPJDS and received the best paper award in last year's WWW'15 conference. He received his PhD in computer Science from the Technical University of Graz (Austria) For more information see http:/www.philippsinger.info/
School health promotion and teacher professional identity

Health and education are inextricably linked. Health promotion sits somewhat uncomfortably within schools, often remaining a marginal aspect of teachers' work. The purpose of this paper is to examine the compatibility of an HP initiative with teacher professional identity.  A qualitative research design was adopted consisting of semi structured interviews. In total, 49 teachers in two school districts in the Auvergne region in central France were interviewed in depth post having completed three years' involvement in a health promoting schools initiative called "Learning to Live Better Together" "Apprendre a Mieux Vivre Ensemble"  Teachers in the study had a broad conceptualisation of their role in health promotion. In keeping with international trends, there was more success at classroom than at whole school level. While generally teachers can be reluctant to engage with health promotion, the teachers in this study identified having little difficulty in understanding their professional identity as health promoters and identified strong compatibility with the HP initiative.  Teachers generally viewed professional development in health promotion in a positive light when its underlying values were commensurate with their own and when the context was seen as compatible with the school mission. The promotion of health in schools needs to be sensitive to professional identity and be tailored specifically to blend more successfully with current teacher identity and practice.  The promotion of health in schools needs to be sensitive to professional identity and be tailored specifically to blend more successfully with current teacher identity and practice.
Integrative Public Health Aligned Physical Education and Implications for the Professional Preparation of Future Teachers and Teacher Educators/Researchers in the Field

This article has two purposes: (a) to consider existing platforms and future possibilities in the United States for what the authors refer to as Integrative Public Health Aligned Physical Education (IPHPE) which integrates standards based K 12 physical education with a public health agenda focusing on promoting increased physical activity and fitness, and (b) to consider the implications of IPHPE for the preparation of future physical education teachers and teacher educators/researchers. First, the historical context that has nurtured the development of ideologies that inform IPHPE is summarized. Second, examples of these ideologies in terms of their current and prospective contributions to IPHPE perspectives are discussed. Third, building from existing public health aligned recommendations for pre service physical education teacher education (PETE) programs, IPHPE based professional preparation requirements for future physical education teachers are considered. Finally, the focus shifts to doctoral PETE (D PETE) programming and professional preparation requirements for future physical education teacher educators/researchers from an IPHPE perspective. The overall intention of this article is to propose a way forward for physical education which bridges educational priorities of the profession to contemporary and relevant public health needs.
Efficient and accurate modeling of electron photoemission in nanostructures with TDDFT

We derive and extend the time dependent surface flux method introduced in [L. Tao, A. Scrinzi,  (2012) within a time dependent density functional theory (TDDFT) formalism and use it to calculate photoelectron spectra and angular distributions of atoms and molecules when excited by laser pulses. We present other, existing computational TDDFT methods that are suitable for the calculation of electron emission in compact spatial regions, and compare their results. We illustrate the performance of the new method by simulating strong field ionization of C60 fullerene and discuss final state effects in the orbital reconstruction of planar organic molecules.
The Effect of Fetal Bovine Serum (FBS) on Efficacy of Cellular Reprogramming for Induced Pluripotent Stem Cell (iPSC) Generation
Venue: Cell transplantation

Induced pluripotent stem cells (iPSCs) are pivotal to the advancement of regenerative medicine. However, the low efficacy of iPSC generation and insufficient knowledge about the reprogramming mechanisms involved in somatic cell/adult stem cell reversion to a pluripotent phenotype remain critical hurdles to the therapeutic application of iPSCs. The present study investigated whether the concentration of fetal bovine serum (FBS) a widely employed cell culture additive, can influence the cellular reprogramming efficacy (RE) of human adipose derived stem cells (hADSCs) to generate iPSCs. Compared with the typically employed concentration of FBS (10% high concentrations (20% and 30% increased the RE of hADSCs by approximately twofold, whereas a low concentration (5% decreased the RE by the same extent. Furthermore, cell counting kit 8 (CCK 8) bromodeoxyuridine (BrdU) incorporation, and fluorescence activated cell sorting (FACS) assays showed that hADSC proliferation during reprogramming was significantly enhanced by FBS at 20% and 30% whereas quantitative polymerase chain reaction (qPCR) and Western blotting assays revealed a concomitant decrease in p53, p51, and p21 expression. In addition, the efficacy of retrovirus mediated transduction into hADSCs was increased by approximately 10% at high concentrations of FBS. It was confirmed that platelet derived growth factor in the FBS enhanced proliferation and reprogramming efficacy. Finally, the generated iPSCs showed a normal karyotype, the same fingerprinting pattern as parental hADSCs, a genome wide transcriptome pattern similar to that of human embryonic stem cells (hESCs) and in vivo pluripotency. In conclusion, the current investigation demonstrated that high concentrations of FBS can modulate molecular and cellular mechanisms underlying the reprogramming process in hADSCs, thereby augmenting the cellular RE for iPSC generation.
FBS or BSA Inhibits EGCG Induced Cell Death through Covalent Binding and the Reduction of Intracellular ROS Production
Venue: BioMed research international

Previously we have shown that epigallocatechin gallate (EGCG) can induce nonapoptotic cell death in human hepatoma HepG2 cells only under serum free condition. However, the underlying mechanism for serum in determining the cell fate remains to be answered. The effects of fetal bovine serum (FBS) and its major component bovine serum albumin (BSA) on EGCG induced cell death were investigated in this study. It was found that BSA, just like FBS, can protect cells from EGCG induced cell death in a dose dependent manner. Detailed analysis revealed that both FBS and BSA inhibited generation of ROS to protect against toxicity of EGCG. Furthermore, EGCG was shown to bind to certain cellular proteins including caspase 3, PARP, and a tubulin, but not LC3 nor b actin, which formed EGCG protein complexes that were inseparable by SDS gel. On the other hand, addition of FBS or BSA to culture medium can block the binding of EGCG to these proteins. In silico docking analysis results suggested that BSA had a stronger affinity to EGCG than the other proteins. Taken together, these data indicated that the protective effect of FBS and BSA against EGCG induced cell death could be due to (1) the decreased generation of ROS and (2) the competitive binding of BSA to EGCG.
Examining the Impact of Social Media on Internet Banking

The technology has leveraged innovative modes of socializing, from facebook to twitter, man has become more social than ever before. But is the social media only limited to networking with the friends and reference groups or is there is more to it. This has been a big challenge for marketers to understand this consumer behavior. Since the interactions between people on these media are not only limited to personal chats but also include sharing experiences about purchases, preferences for brands and personal feelings about products. In response to its growing acceptability, popularity and impact the businesses are also turning to social media to market, promote their products and to interact with their customer and understand their changing needs and behavior. The present paper investigates the influence of support taken from social platforms on internet purchasing in India. The implications for the practitioners and researchers are discussed.
The Influence of Social Media and Internet Presence on Small, Local Banks' Market Power: New Evidence from an Emerging Economy

We study the impact of late adoption of online banking and early presence on social media on the market power of small banks in Poland. We combine publicly available information with two unique, hand collected datasets on the geo location of all bank branches and on small banks' Internet and social media presence. We find that late adopting banks must forego some of their market power to reach new customers through Internet banking. The size of the necessary market power sacrifice is smaller when small banks primarily compete against their peers within local banking markets than against larger commercial banks. Additionally, we observe that an early and aggressive embrace of Facebook as a method of communication was beneficial for small local banks in terms of interest income.
Customers' Expectations for Next Generation Internet Banking
Venue: J. Inf. Knowl. Manag.

This paper posits six new factors that impact customers' expectations for next generation internet banking. The factors are innovative interface, integration with social media, money management tools, instant customer service, enhanced convenience, and next generation security. The data was collected from 310 respondents, who currently use internet banking services from leading countries. The results suggest that three factors, namely, integration with social media, money management tools, and enhanced convenience, would significantly affect customers' expectations for next generation internet banking. The results also suggest the role of innovative interface, next generation security, and instant customer support and service in influencing the customers' expectations. The proposed model would be useful for banks and technology providers to not only understand bank customers' expectations, but also to launch innovative marketing strategies to gain competitive advantage, and to craft a unique selling proposition to its customers.
The Internet, Crowdfunding and the Banking Industry

This chapter discusses some issues at the crossroads between the Internet and banking. It focuses on the impact of the Internet on the banking industry. As the topic is still very broad and the available space limited, only a selected number of more specific themes are covered. The section "The Internet, Network Effects and the Horizontalization of Organizations" discusses network effects and the horizontalization of established organizations and communications that arise from the Internet and social media, and how such horizontalization may ultimately affect market structure. The section "Loan Based Crowdfunding, Peer to Peer Lending and the Banking Industry" covers the main theme of the chapter, namely loan based crowdfunding and peer to peer lending. This new form of corporate finance for smaller businesses is likely to affect banks' core activities in several ways, some of which have already been studied in recent years. The section "Further Issues" discusses a few other topics related to the Internet and the banking industry that have attracted attention among researchers and for which data have become available. "Concluding Remarks" draws the chapter to a close.