nils-herrmann/clean_scirepeval huggingface dataset:
A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A.
Venue: The New England journal of medicine

The development of neutralizing anti factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.  We conducted a randomized trial to assess the incidence of factor VIII inhibitors among patients treated with plasma derived factor VIII containing von Willebrand factor or recombinant factor VIII. Patients who met the eligibility criteria (male sex, age <6 years, severe hemophilia A, and no previous treatment with any factor VIII concentrate or only minimal treatment with blood components) were included from 42 sites.  Of 303 patients screened, 264 underwent randomization and 251 were analyzed. Inhibitors developed in 76 patients, 50 of whom had high titer inhibitors =5 Bethesda units) Inhibitors developed in 29 of the 125 patients treated with plasma derived factor VIII (20 patients had high titer inhibitors) and in 47 of the 126 patients treated with recombinant factor VIII (30 patients had high titer inhibitors) The cumulative incidence of all inhibitors was 26.8% (95% confidence interval [CI] 18.4 to 35.2) with plasma derived factor VIII and 44.5% (95% CI, 34.7 to 54.3) with recombinant factor VIII; the cumulative incidence of high titer inhibitors was 18.6% (95% CI, 11.2 to 26.0) and 28.4% (95% CI, 19.6 to 37.2) respectively. In Cox regression models for the primary end point of all inhibitors, recombinant factor VIII was associated with an 87% higher incidence than plasma derived factor VIII (hazard ratio, 1.87; 95% CI, 1.17 to 2.96) This association did not change in multivariable analysis. For high titer inhibitors, the hazard ratio was 1.69 (95% CI, 0.96 to 2.98) When the analysis was restricted to recombinant factor VIII products other than second generation full length recombinant factor VIII, effect estimates remained similar for all inhibitors (hazard ratio, 1.98; 95% CI, 0.99 to 3.97) and high titer inhibitors (hazard ratio, 2.59; 95% CI, 1.11 to 6.00)  Patients treated with plasma derived factor VIII containing von Willebrand factor had a lower incidence of inhibitors than those treated with recombinant factor VIII. (Funded by the Angelo Bianchi Bonomi Foundation and others; ClinicalTrials.gov number, NCT01064284; EudraCT number, 2009 011186 88.
Factor VIII Mimetic Function of Humanized Bispecific Antibody in Hemophilia A.
Venue: The New England journal of medicine

In patients with severe hemophilia A, standard treatment is regular prophylactic and episodic intravenous infusions of factor VIII. However, these treatments are burdensome, especially for children, and may lead to the formation of anti factor VIII alloantibodies (factor VIII inhibitors) Emicizumab (ACE910) a humanized bispecific antibody mimicking the cofactor function of factor VIII, was developed to abate these problems.  We enrolled 18 Japanese patients with severe hemophilia A (with or without factor VIII inhibitors) in an open label, nonrandomized, interindividual dose escalation study of emicizumab. The patients received subcutaneous emicizumab weekly for 12 weeks at a dose of 0.3, 1.0, or 3.0 mg per kilogram of body weight (cohorts 1, 2, and 3, respectively) The end points were safety and pharmacokinetic and pharmacodynamic profiles. An additional, exploratory end point was the annualized bleeding rate, calculated as 365.25 times the number of bleeding episodes, divided by the number of days in the treatment period as compared with the 6 months before enrollment.  Emicizumab was associated with neither serious adverse events nor clinically relevant coagulation abnormalities. Plasma concentrations of emicizumab increased in a dose dependent manner. Activated partial thromboplastin times remained short throughout the study. The median annualized bleeding rates in cohorts 1, 2, and 3 decreased from 32.5 to 4.4, 18.3 to 0.0, and 15.2 to 0.0, respectively. There was no bleeding in 8 of 11 patients with factor VIII inhibitors (73% and in 5 of 7 patients without factor VIII inhibitors (71% Episodic use of clotting factors to control bleeding was reduced. Antibodies to emicizumab did not develop.  Once weekly subcutaneous administration of emicizumab markedly decreased the bleeding rate in patients who had hemophilia A with or without factor VIII inhibitors.
Der Weg zur erfolgreichen Vermarktung von Krankenhausleistungen

Erst seit Inkrafttreten des 2. Fallpauschalenanderungsgesetzes (Anfang 2005) ist es moglich, das Leistungsvolumen eines Krankenhauses durch qualitativ hochwertige Behandlungen auszuweiten. Zuvor galt Wettbewerb um Patienten unter Medizinern als eher unfein. Auch die Geschaftsleitungen der Krankenhauser fuhlten sich einander freundschaftlich verbunden, verstanden sich mehr als Teil eines gemeinsamen, abgestimmten Versorgungssystems denn als Wettbewerber.
Stationary Zonal Flows during the Formation of the Edge Transport Barrier in the JET Tokamak.
Venue: Physical review letters

High spatial resolution Doppler backscattering measurements in JET have enabled new insights into the development of the edge Er. We observe fine scale spatial structures in the edge Er well with a wave number krri0.4 0.8, consistent with stationary zonal flows, the characteristics of which vary with density. The zonal flow amplitude and wavelength both decrease with local collisionality, such that the zonal flow ExB shear increases. Above the minimum of the L H transition power threshold dependence on density, the zonal flows are present during L mode and disappear following the H mode transition, while below the minimum they are reduced below measurable amplitude during L mode, before the L H transition.
Intermediate k density and magnetic field fluctuations during inter ELM pedestal evolution in MAST

Measurements of local density and magnetic field fluctuations near the pedestal top, conditionally averaged over the edge localized mode (ELM) cycle, have been made in Mega Amp Spherical Tokamak (MAST) A Doppler backscattering (DBS) system installed at MAST was used to measure intermediate k density fluctuations at the top of the pedestal. A novel diagnostic technique combining DBS with cross polarization scattering (CP DBS) enabled magnetic field fluctuations to also be locally measured at similar wave numbers. Polarization isolation and other effects for CP DBS are discussed. Both measurements were used in a series of high b 4.5) MAST plasmas with large type I ELMs with an period where microtearing modes (MTMs) had been predicted to be unstable in similar conditions (Dickinson 2012  The measured density fluctuation level increased by a factor of about 4 between 2 and 4 ms after the ELM, which was correlated with the recovery of the density profile while the temperature pedestal height continued to increase slowly. Magnetic field fluctuations showed different temporal behaviors, slowly increasing throughout the ELM cycle as the local b increased. Linear GS2 calculations show both MTM and electron temperature gradient (ETG) modes unstable at similar wave numbers as the measurements (although with more overlap between ETG wave numbers and diagnostic spectral resolution) at the top of the pedestal, along with kinetic ballooning modes are unstable lower in the pedestal (at larger wavelengths) The inferred ratio of fluctuation levels from experiment was The comparable ratios from GS2 were for the MTM and for the ETG. Both the experimental wave number range and the fluctuation ratio are more similar to the linear characteristics of the ETG than the MTM. These results imply that intermediate k fluctuations due to the ETG play a role in inter ELM pedestal evolution.
First Results from Recent JET Experiments in Hydrogen and Hydrogen Deuterium Plasmas

The hydrogen campaign completed at JET in 2016 has demonstrated isotope ratio control in JET ILW using gas puffing and pellets for fuelling, Neutral Beam Injection alone or in combination, with D/H spectroscopy as a diagnostic. The plasma properties such as confinement, L H threshold, density limit depend on the isotope composition. The L H transition power increases with the hydrogen concentration with a wide plateau in the range 0.2<nH/(nD+nH)<0.8. Energy confinement is significantly lower in hydrogen than in comparable deuterium ELMy H mode plasmas, suggesting an isotope mass scaling that is stronger than in IPB98(y,2) In L mode, the isotope dependence of confinement is weaker. The H mode density limit in hydrogen is up to 35% lower than in heuterium, whilst it is found to be higher in L mode. The lower ion mass leads to reduced tungsten sputtering in hydrogen plasmas. During the campaign, the nD/(nD+nH) ratio dropped to 1% in only a few discharges after the last deliberate introduction of deuterium, although it was seen to rise again to 2% with several seconds of exposure of the divertor tiles to 10MW of auxiliary heating. Several ICRH scenarios were also tested in hydrogen plasmas.
Predicting the effects of automation reliability rates on human automation team performance
Venue: 2016 Winter Simulation Conference (WSC)

This study investigates the effects of reduced automation reliability rates on human automation team performance. Specifically, System Modeling Language (SysML) activity diagrams and Improved Performance Research Integrated Tool (IMPRINT) models are developed for a tablet based game which includes an automated teammate. The baseline model uses previously collected data from human in the loop experiments where the automated teammate performs with 100% reliability. It is expected that team performance and user trust in automation will be affected if the automation is less reliable. The baseline model is modified to create alternate models that incorporate degraded automation reliability rates from 50% to 90% This study finds that when automation reliability was 100% the automation was an effective teammate and enabled the human automation team to achieve statistically improved performance over human only scenarios. However, at reliability rates of 90% and less, the presence of the automated agent degraded system performance to levels less than achieved in human only scenarios.
The Role of Simulation in Designing Human Automation Systems
Venue: HCI

Human machine teaming is becoming an ever present aspect of executing modern military missions. In this paper, we discuss an extensive line of research currently being conducted at the Air Force Institute of Technology focused specifically on using simulation in the design of automated systems in order to improve human automation interactions. This research includes efforts to predict operator performance, mental workload, situation awareness, trust, and fatigue. This research explores using simulation to design interfaces, perform trade studies, create adaptive systems, and make task allocation decisions.
Multi View 3D Object Retrieval With Deep Embedding Network
Venue: IEEE Transactions on Image Processing

In multi view 3D object retrieval, each object is characterized by a group of 2D images captured from different views. Rather than using hand crafted features, in this paper, we take advantage of the strong discriminative power of convolutional neural network to learn an effective 3D object representation tailored for this retrieval task. Specifically, we propose a deep embedding network jointly supervised by classification loss and triplet loss to map the high dimensional image space into a low dimensional feature space, where the Euclidean distance of features directly corresponds to the semantic similarity of images. By effectively reducing the intra class variations while increasing the inter class ones of the input images, the network guarantees that similar images are closer than dissimilar ones in the learned feature space. Besides, we investigate the effectiveness of deep features extracted from different layers of the embedding network extensively and find that an efficient 3D object representation should be a tradeoff between global semantic information and discriminative local characteristics. Then, with the set of deep features extracted from different views, we can generate a comprehensive description for each 3D object and formulate the multi view 3D object retrieval as a set to set matching problem. Extensive experiments on SHREC'15 data set demonstrate the superiority of our proposed method over the previous state of the art approaches with over 12% performance improvement.
Exploring the bioactive potential of Serriatia marcescens VITAPI (Acc: 1933637) isolated from soil
Venue: Frontiers in Biology

BACKGROUNDSerratia is one of the most important groups of bacteria which produces proteolytic enzymes effectively and known to possess anti inflammatory properties. The main focus of the current study was to extract the enzyme serratiopeptidase and pigment prodigiosin from Serratia mascescens. Prodigiosin is a red colored pigment produced by the bacterium Serratia marcescens. It is emerging as a valuable molecule because of its large applications. It has already been proved that pigmented strain of Serratia marcescens is less virulent than non pigmented strains. Moreover the strain we have obtained is from farm soil which indicates that prodigiosin production can be carried safely using this strain.METHODSIn the present study, the isolate VITASP strain was confirmed by morphological, biochemical and molecular studies. The enzyme and pigment were analyzed for anti oxidant, anti inflammatory and cytotoxic properties.RESULTSThe isolate was further confirmed and identified as Serratia marcescens with 99% similarity. The extracted pigment showed potent radical scavenging effect with 86% and the enzyme was found to inhibit 83% which was significant in comparison to ascorbic acid standard. The in vitro anti inflammatory effect of pigment in controlled experimental conditions revealed its protection at 88% and the enzyme with 90% Aspirin was used as the reference drug. The present findings exhibited a concentration dependent inhibition. The cytotoxic bioassay of pigment showed the IC50 value as (50) mg/mL with 63% cytotoxicity which was statistically significant compared to positive control.CONCLUSIONTherefore, it appears to be an essential remedial and application research. It may turn out to be highly beneficial to mankind in solving many problems associated with human health.
Anodic Oxidation of Sulfide to Sulfate: Effect of the Current Density on the Process Kinetics

The kinetics of the conversion of sulfide to sulfate by electro oxidation, using a boron doped diamond (BDD) electrode was studied. Different applied current densities were tested, from 10 to 60 mA cm 2. The results showed that the electrochemical conversion of sulfide to sulfate occurs in steps, via intermediate production of other sulfur species. The oxidation rate of the sulfide ion is dependent on its concentration and current density. The reaction order varies with the current intensity, being 2 for the lower applied current intensity and high S2 concentration, which is compatible with a mechanism involving two S2 ions to give S22 For higher current densities, where current control is less important, reaction order varies from 0.15 to 0.44 for the current densities of 20 and 60 mA cm 2, respectively. For the formation of SO42 from S2 electro oxidation, the reaction orders with respect to sulfide concentration and current intensity are 0 and 1, respectively.
Minimap and miniasm: fast mapping and de novo assembly for noisy long sequences
Venue: Bioinform.

sequencing technology and Oxford Nanopore technologies (ONT) produce reads over 10 kb in length, which have enabled high quality genome assembly at an affordable cost. However, at present, long reads have an error rate as high as 10 15% Complex and computationally intensive pipelines are required to assemble such reads.  We present a new mapper, minimap and a de novo assembler, miniasm, for efficiently mapping and assembling SMRT and ONT reads without an error correction stage. They can often assemble a sequencing run of bacterial data into a single contig in a few minutes, and assemble 45 fold Caenorhabditis elegans data in 9 min, orders of magnitude faster than the existing pipelines, though the consensus sequence error rate is as high as raw reads. We also introduce a pairwise read mapping format and a graphical fragment assembly format, and demonstrate the interoperability between ours and current tools. AVAILABILITY AND IMPLEMENTATION https:/github.com/lh3/minimap and https:/github.com/lh3/miniasm CONTACT hengli@broadinstitute.org SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Graphene oxide/PEDOT:PSS composite hole transport layer for efficient and stable planar heterojunction perovskite solar cells.
Venue: Nanoscale

We investigated a graphene oxide (GO)/poly(3,4 ethylenedioxythiophene):poly(styrene sulfonate) PEDOT PSS) composite as a promising candidate for the practical application of a 2 D carbonaceous hole transport layer (HTL) to planar heterojunction perovskite solar cells (PeSCs) consisting of a transparent electrode/HTL/perovskite/fullerene/metal electrode. Both the insulating properties of GO and the non uniform coating of the transparent electrode with GO cause the poor morphology of perovskite induced low power conversion efficiency (PCE) of 6.4% On the other hand, PeSCs with a GO/PEDOT:PSS composite HTL, exhibited a higher PCE of 9.7% than that of a device fabricated with conventional PEDOT PSS showing a PCE of 8.2% The higher performance is attributed to the decreased series resistance (RS) and increased shunt resistance (RSh) The well matched work function between GO (4.9 eV) and PEDOT PSS (5.1 eV) probably results in more efficient charge transport and an overall decrease in RS. The existence of GO with a large bandgap of ~3.6 eV might induce the effective blocking of electrons, leading to an increase of RSh. Moreover, improvement in the long term stability under atmospheric conditions was observed.
Improved air stability of perovskite solar cells via solution processed metal oxide transport layers.
Venue: Nature nanotechnology

Lead halide perovskite solar cells have recently attracted tremendous attention because of their excellent photovoltaic efficiencies. However, the poor stability of both the perovskite material and the charge transport layers has so far prevented the fabrication of devices that can withstand sustained operation under normal conditions. Here, we report a solution processed lead halide perovskite solar cell that has p type NiO(x) and n type ZnO nanoparticles as hole and electron transport layers, respectively, and shows improved stability against water and oxygen degradation when compared with devices with organic charge transport layers. Our cells have a p i n structure (glass/indium tin oxide/NiO(x)/perovskite/ZnO/Al) in which the ZnO layer isolates the perovskite and Al layers, thus preventing degradation. After 60 days storage in air at room temperature, our all metal oxide devices retain about 90% of their original efficiency, unlike control devices made with organic transport layers, which undergo a complete degradation after just 5 days. The initial power conversion efficiency of our devices is 14.6 1.5% with an uncertified maximum value of 16.1%
PEMERINGKATAN E GOVERNMENT INDONESIA (PEGI) DAN PEMANFAATAN TEKNOLOGI INFORMASI DI DKI JAKARTA

in participatory governance in order to achieve a prosperous and cultured society. That called a smart city. DKI Jakarta provincial government has using ICT to provide information and public services. E government performance can be assessed by some standards, which one is the e government rankings Indonesia (PeGI) PeGI consists of five dimensions, there are two dimensions relating to ICTs, infrastructures and applications. The development of the wireless internet technology impacted on increase of a mobile device smartphone user. The internet users in Jakarta in the majority used the telephone mobile smartphone to access the Internet and government's mobile applications, such as Waze which widely use to monitoring traffic and help to searching alternatif way on traffic congestion. Utilization of information technology increases the provincial government's performance, as proved by the survey results and previous studies. For three consecutive years, 2012 until 2015, the performance of DKI Jakarta has increased, from the third ranking to the first ranking, and achieved a good performance appraisal. This achievement is inseparable from good IT governance. Keyword e Government ranking of Indonesia (PeGI) internet, Jakarta smart city, mobile based applications, utilization of information technology Abstrak DKI Jakarta memiliki visi untuk menciptakan sebuah kota modern dan inovatif, mampu mengelola sumber daya kota secara efektif, efisien dan berkelanjutan dengan mengoptimalkan TIK (Teknologi Informasi dan Komunikasi) dalam pemerintahan partisipatif dalam rangka mencapai masyarakat yang sejahtera dan berbudaya. Yang disebut kota pintar. Pemprov DKI Jakarta telah menggunakan TIK untuk memberikan informasi dan pelayanan publik. Kinerja E pemerintah dapat dinilai dengan beberapa standar, yang satu adalah e government peringkat Indonesia (PeGI) PeGI terdiri dari lima dimensi, ada dua dimensi yang berkaitan dengan TIK, yaitu infrastruktur dan aplikasi. Perkembangan teknologi internet nirkabel berdampak pada peningkatan pengguna perangkat/ ponsel smartphone. Para pengguna internet di Jakarta mayoritas menggunakan telepon/ ponsel smartphone untuk mengakses internet dan aplikasi mobile pemerintah, seperti Waze yang banyak digunakan untuk memonitor lalu lintas dan membantu untuk mencari jalan alternatif pada kemacetan lalu lintas. Pemanfaatan teknologi informasi meningkatkan kinerja pemerintah provinsi, seperti yang dibuktikan oleh hasil survei dan penelitian sebelumnya. Selama tiga tahun berturut turut, 2012 sampai dengan tahun 2015, kinerja DKI Jakarta telah meningkat, dari peringkat ketiga ke peringkat pertama, dan mencapai penilaian kinerja yang baik. Prestasi ini tidak terlepas dari tata kelola TI yang baik. Kata kunci: aplikasi berbasis mobile, internet, Jakarta smart city, pemanfaatan teknologi informasi, Pemeringkatan e Government Indonesia (PeGI)
UJI VALIDITAS INDIKATOR INDIKATOR PEMERINGKATAN E GOVERNMENT INDONESIA (PEGI) TINGKAT PROVINSI DENGAN ANALISIS FAKTOR

Faktor penilaian PeGI terdiri dari dimensi kebijakan, kelembagaan, infrastruktur, aplikasi, dan perencanaan. Implementasi e government tingkat provinsi belum optimal, dari 26 provinsi yang dinilai, hanya 7 provinsi yang mendapat peringkat baik pada tahun 2011. Penelitian ini bertujuan untuk menguji validitas indikator indikator dari dimensi kebijakan, kelembagaan, infrastruktur, aplikasi, dan perencanaan. Metode penelitian ini menggunakan pendekatan kuntitatif dengan teknik analisis faktor. Hasil dari penelitian ini, untuk dimensi kebijakan, kelembagaan, infrastruktur, dan perencanaan seluruh indikatornya valid untuk digunakan dalam penilaian PeGI. Dimensi aplikasi tidak semuanya valid, indikator untuk aplikasi yang tidak valid adalah aplikasi manajemen keuangan.