nils-herrmann/clean_scirepeval huggingface dataset:
Prognostic role of C reactive protein in breast cancer an updated systematic review and meta analysis

The C reactive protein (CRP) an inflammatory biomarker, has been identified to be related to progression of breast cancer. However, the results remain controversial. A meta analysis of epidemiologic studies was therefore conducted to address this issue. Data were collected from studies comparing overall, cancer specific, and diseasefree survival (OS, CSS, and DFS) in patients with per natural log unit change in CRP. Study specific risk estimates were pooled using a random effects model. Sixteen studies involving a total of 15,545 breast cancer cases were included in this meta analysis. The pooled results showed that per natural log unit change in CRP was significantly associated with poor OS (HR 1.28, 95% CI 1.13 1.44) and DFS (HR 1.18, 95% CI 1.04 1.34) For CSS, the pooled HR was 1.38 (95% CI 1.15 1.66) which could strongly predict poorer survival in breast cancer patients. Similar results were also observed in the stratified analyses by number of patients, treatment, max follow up and CRP marker. The meta analysis indicated that elevated CRP levels has a critical prognostic value in patients with breast cancer as an inflammation biomarker.
The job analysis of Korean nurses as a strategy to improve the Korean Nursing Licensing Examination
Venue: Journal of educational evaluation for health professions

This study aimed at characterizing Korean nurses' occupational responsibilities to apply the results for improvement of the Korean Nursing Licensing Examination.  First, the contents of nursing job were defined based on a focus group interview of 15 nurses. Developing a Curriculum (DACOM) method was used to examine those results and produce the questionnaire by 13 experts. After that, the questionnaire survey to 5,065 hospital nurses was done.  The occupational responsibilities of nurses were characterized as involving 8 duties, 49 tasks, and 303 task elements. Those 8 duties are nursing management and professional development, safety and infection control, the management of potential risk factors, basic nursing and caring, the maintenance of physiological integrity, medication and parenteral treatments, socio psychological integrity, and the maintenance and improvement of health.  The content of Korean Nursing Licensing Examination should be improved based on 8 duties and 49 tasks of the occupational responsibilities of Korean nurses.
A Study on The Internet Connectivity in The Philippines

This study aims to help address concerns about the growing demand of wider bandwidth Internet connection in the Philippines. Using articles and research of international organizations and content from official websites of the Philippine government, this paper has carefully examined the slow Internet connectivity and the high cost that the end users pay for it. This paper suggests that this inefficiency hampers the motivation of users to innovate in a way that could contribute to inclusive growth and the development of an inclusive information society. Through a comparison of the current global ICT situation with the current situation in the Philippines, this paper shows that the country's Internet infrastructure lags behind among those of contemporary developing countries in Asia, particularly in terms of Internet connectivity. In 2015, Thailand had an average Internet speed of 7.4 Mbps, Sri Lanka 7.4, and Malaysia 4.3. Meanwhile, the Philippines had a meager average Internet speed of 2.8 Mbps, placing the country at 104 among 160 countries, with developed countries in Asia such as South Korea (23.6 Mbps) and Singapore (12.9 Mbps) ranking 1 and 12, respectively. Findings show that the lack of competition in the Internet connectivity market, among other reasons, is at the root of the dilemma of slow and costly Internet connection. Assessing the accomplishments of the Republic of Korea and other broadband leading countries has provided practical insights and recommendations that can promote competitiveness. Furthermore, related literature argues how ISP practices may affect Internet speed and cost. This study offers an approach in improving Internet connectivity in the Philippines by bridging the gap between the Internet infrastructure market and government policies.
Improvement in magnetic behaviour of cobalt doped magnesium zinc nano ferrites via co precipitation route

Nanoparticles of spinel ferrites have attracted huge interest in various technological applications due to their distinct magnetic behaviour. These magnetic nanoparticles acquire surface and finite size effects. We report an improvement of magnetic characteristics in Co 2 substituted Mg Zn nano ferrites synthesized by co precipitation route. Physical properties have been investigated for Mg 0.5 Zn 0.5 x Co x Fe 2 O 4 x 0, 0.125, 0.250, 0.375, 0.500) nano ferrites using XRD, FTIR, FESEM, EDS, VSM, photoluminescence and UV spectroscopy. Single phase cubical spinel structure has been observed. A phase transition from superparamagnetic to ferrimagnetic behaviour for x 0.125 has been observed. Saturation magnetization has been found to be enhanced. Frequency dependent dielectric behaviour shows normal dispersion. Absorption spectra show a shift in position of maximum absorption towards longer wavelength with increasing Co 2+ content. Photoluminescence spectroscopy has also confirmed the red shift in band edge emission with increasing Co 2+ content. Some theoretical parameters, using proposed cation distribution, like theoretical lattice parameter, oxygen positional parameter, bond length etc. have also been calculated and found to support our experimental results.
Organocatalytic Domino Oxa Michael/1,6 Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds.
Venue: Angewandte Chemie

An asymmetric organocatalytic domino oxa Michael/1,6 addition reaction of ortho hydroxyphenyl substituted para quinone methides and isatin derived enoates has been developed. In the presence of 5 mol of a bifunctional thiourea organocatalyst, this scalable domino reaction affords 4 phenyl substituted chromans bearing spiro connected oxindole scaffolds and three adjacent stereogenic centers in good to excellent yields (up to 98 and with very high stereoselectivities (up to >20:1 d.r. >99 ee)
Contact Stress and Shear Stress Analysis of Spur Gear Using ANSYS and Theoretical

In this paper the bending stress over the lower addendum of the spur gear, shear and contact stresses by using the software tools like pro e and ANSYS are employed to design and analysis. Here in, we report the contact stress analysis of stainless steel spur gears by theoretical method using Hertz equations and by finite element analysis using FEA software ANSYS 15.0 workbench. The spur gear is sketched and modelled in ANSYS design modeller and the contact stress analysis is done in mechanical ANSYS multi physics. The ANSYS software avoids tedious calculations presumably impending in the design procedure and uses ultimate numerical tool to approximate the solution of the partial differential equations associated with continuity, momentum and energy phases of a flow problem in a 3 D model. The designed 3 D model from Pro E is inhibited in the ANSYS. This exquisite feature of ANSYS enables designer to optimize the design procedure in an iterative manner based on the final plots of post processing phase.
Deinkability of thermochromic offset inks

This paper evaluates the deinkability of thermochromic offset inks. For this purpose, three thermochromic inks were printed on white uncoated paper, in laboratory conditions. These prints were mixed in equal shares and recycled by means of chemical deinking flotation under defined conditions in the laboratory according to INGEDE method 11p. Deinkability is evaluated by calculating the flotation yield, pulp's brightness and whiteness increase and the colour properties, determination of residual ink area, as well as ash content elimination. The obtained results indicate that thermochromic prints are poorly deinkable. The image analysis shows that flotation deinking managed to eliminate only 12.8% of the total dirt area of thermochromic ink. Only a small increase in deinked handsheets brightness and whiteness (approx. 5% and 2% is noticed. The results of surface properties determination showed that the adhesion of inks on the paper is high. Thermochromic inks can affect wastewater too, by affecting its colouration due to their interactions with deinking solution and/or as a result of their mechanical damage during defibration.
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.
Venue: American journal of physiology. Endocrinology and metabolism

The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism and is closely coupled to cellular respiration, free radical generation, and inflammation. Oxidative flux through the TCA cycle is induced during hepatic insulin resistance, in mice and humans with simple steatosis, reflecting early compensatory remodeling of mitochondrial energetics. We hypothesized that progressive severity of hepatic insulin resistance and the onset of nonalcoholic steatohepatitis (NASH) would impair oxidative flux through the hepatic TCA cycle. Mice (C57/BL6) were fed a high trans fat high fructose diet (TFD) for 8 wk to induce simple steatosis and NASH by 24 wk. In vivo fasting hepatic mitochondrial fluxes were determined by(13)C nuclear magnetic resonance (NMR) based isotopomer analysis. Hepatic metabolic intermediates were quantified using mass spectrometry based targeted metabolomics. Hepatic triglyceride accumulation and insulin resistance preceded alterations in mitochondrial metabolism, since TCA cycle fluxes remained normal during simple steatosis. However, mice with NASH had a twofold induction (P< 0.05) of mitochondrial fluxes (mmol/min) through the TCA cycle (2.6 0.5 vs. 5.4 0.6) anaplerosis (9.1 1.2 vs. 16.9 2.2) and pyruvate cycling (4.9 1.0 vs. 11.1 1.9) compared with their age matched controls. Induction of the TCA cycle activity during NASH was concurrent with blunted ketogenesis and accumulation of hepatic diacylglycerols (DAGs) ceramides (Cer) and long chain acylcarnitines, suggesting inefficient oxidation and disposal of excess free fatty acids (FFA) Sustained induction of mitochondrial TCA cycle failed to prevent accretion of "lipotoxic" metabolites in the liver and could hasten inflammation and the metabolic transition to NASH.
Testing an extended model of consumer behavior in the context of social media based brand communities
Venue: Comput. Hum. Behav.

Due to the benefits of brand community initiatives and the potential advantages of social media, many marketing managers made significant investments in building brand communities based on social media. A noticeable issue is how to measure the success of such investments in ways that are understandable and comparable to other marketing initiatives. To address this issue, it is essential to understand how social media based brand communities influence customers' perceptions and behaviors. The purpose of this article is to develop and estimate an extended model of how different aspects of customers' relationships with such communities influence their perceptions and behaviors. The paper describes a way a customer's identification with a brand influences relationships with brand community elements, brand community markers, and ultimately brand relationship quality and brand loyalty. Then using a large sample of brand community members in social media and structural equation modeling, the authors estimate how social media based brand communities influence brand relationship quality and brand loyalty. Managerial implications are discussed.
The influence of social media interactions on consumer brand relationships: A three country study of brand perceptions and marketing behaviors

Companies are increasingly allocating more of their marketing spending to social media programs. Yet there is little research about how social media use is associated with consumer brand relationships. We conducted three studies to explore how individual and national differences influence the relationship between social media use and customer brand relationships. The first study surveyed customers in France, the U.K. and U.S. and compared those who engage with their favorite brands via social media with those who do not. The findings indicated that social media use was positively related with brand relationship quality and the effect was more pronounced with high anthropomorphism perceptions (the extent to which consumers' associate human characteristics with brands) Two subsequent experiments further validated these findings and confirmed that cultural differences, specifically uncertainty avoidance, moderated these results. We obtained robust and convergent results from survey and experimental data using both student and adult consumer samples and testing across three product categories (athletic shoes, notebook computers, and automobiles) The results offer cross national support for the proposition that engaging customers via social media is associated with higher consumer brand relationships and word of mouth communications when consumers anthropomorphize the brand and they avoid uncertainty.
Mitochondrial transit peptide exhibits cell penetration ability and efficiently delivers macromolecules to mitochondria
Venue: FEBS letters

Mitochondrial malfunction under various circumstances can lead to a variety of disorders. Effective targeting of macromolecules (drugs) is important for restoration of mitochondrial function and treatment of related disorders. We have designed a novel cell penetrating mitochondrial transit peptide (CpMTP) for delivery of macromolecules to mitochondria. Comparison between properties of cell penetrating peptides (CPPs) and mitochondrial signal sequences enabled prediction of peptides with dual ability for cellular translocation and mitochondrial localization. Among the predicted peptides, CpMTP translocates across HeLa cells and shows successful delivery of noncovalently conjugated cargo molecules to mitochondria. CpMTP may have applications in transduction and transfection of mitochondria for therapeutics.
Statistical analysis in method comparison studies Part one

Method comparison is commonly performed by laboratory specialists to assess the comparability of two methods. The quality of method comparison study determines the quality of the results and validity of the conclusions. The key to the successful method comparison is therefore a well designed and carefully planned experiment. The question to be answered by the method comparison is whether two methods could be used interchangeably without affecting patient results and patient outcome. In other words, by comparing two methods we are looking for a potential bias between methods. If bias is larger than acceptable, methods are different and cannot be used interchangeably. It is important to understand why bias cannot be adequately assessed by correlation analysis and by performing t test. It is also important to be aware of the importance of graphical presentation of the data (scatter plots and difference plots) as a first step in data analysis. Graphical presentation of the data will ensure that outliers and extreme values are detected. This article will provide some key concepts related to the design of the method comparison study, data analysis and graphical presentation. Passing Bablok and Deming regression are going to be covered in the subsequent article (part two)  One of the important aspects of the method verification is the assessment of method trueness. Method trueness can be assessed either by following the CLSI EP15 A2 standard, which defines procedure of the verification of performance for precision and trueness, or the CLSI EP09 A3 standard, which provides guidance on how to estimate the bias by comparison of measurement procedures using patient samples  The CLSI EP09 A3 standard also defines several statistical procedures which can be used to describe and analyze the data. The choice of correct statistical procedures for data analysis and knowledge about how to interpret the results of statistical analysis is of key importance for proper assessment of the method trueness. This article provides the insight into the proper design of the method comparison study and some basic considerations about initial steps in data analysis and graphical presentation (scatter and difference plots) The following article will address statistical methods used in method comparison studies (Passing Bablok and Deming regression) Article downloaded from acutecaretesting.org Ana Maria Simundic: Statistical analysis in method comparison studies Part one Page 1
Reconceptualizing Autonomy: A Relational Turn in Bioethics.
Venue: The Hastings Center report

History's judgment on the success of bioethics will not depend solely on the conceptual creativity and innovation in the field at the level of ethical and political theory, but this intellectual work is not insignificant. One important new development is what I shall refer to as the relational turn in bioethics. This development represents a renewed emphasis on the ideographic approach, which interprets the meaning of right and wrong in human actions as they are inscribed in social and cultural practices and in structures of lived meaning and interdependence; in an ideographic approach, the task of bioethics is to bring practice into theory, not the other way around. The relational turn in bioethics may profoundly affect the critical questions that the field asks and the ethical guidance it offers society, politics, and policy. The relational turn provides a way of correcting the excessive atomism of many individualistic perspectives that have been, and continue to be, influential in bioethics. Nonetheless, I would argue that most of the work reflecting the relational turn remains distinctively liberal in its respect for the ethical significance of the human individual. It moves away from individualism, but not from the value of individuality.In this review essay, I shall focus on how the relational turn has manifested itself in work on core concepts in bioethics, especially liberty and autonomy. Following a general review, I conclude with a brief consideration of two important recent books in this area: Jennifer Nedelsky's Law's Relations and Rachel Haliburton's Autonomy and the Situated Self.
CYP2C19 LOF and GOF Guided Antiplatelet Therapy in Patients with Acute Coronary Syndrome: A Cost Effectiveness Analysis
Venue: Cardiovascular Drugs and Therapy

PurposeThis study aimed to examine the cost effectiveness of CYP2C19 loss of function and gain of function allele guided (LOF/GOF guided) antiplatelet therapy in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).MethodsA life long decision analytic model was designed to simulate outcomes of three strategies: universal clopidogrel (75 mg daily) universal alternative P2Y12 inhibitor (prasugrel 10 mg daily or ticagrelor 90 mg twice daily) and LOF/GOF guided therapy (LOF/GOF allele carriers receiving alternative P2Y12 inhibitor, wild type patients receiving clopidogrel) Model outcomes included clinical event rates, quality adjusted life years (QALYs) gained and direct medical costs from perspective of US healthcare provider.ResultsBase case analysis found nonfatal myocardial infarction (5.62% and stent thrombosis (1.2% to be the lowest in universal alternative P2Y12 inhibitor arm, whereas nonfatal stroke (0.72% cardiovascular death (2.42% and major bleeding (2.73% were lowest in LOF/GOF guided group. LOF/GOF guided arm gained the highest QALYs (7.5301 QALYs) at lowest life long cost (USD 76,450) One way sensitivity analysis showed base case results were subject to the hazard ratio of cardiovascular death in carriers versus non carriers of LOF allele and hazard ratio of cardiovascular death in non carriers of LOF allele versus general patients. In probabilistic sensitivity analysis of 10,000 Monte Carlo simulations, LOF/GOF guided therapy, universal alternative P2Y12 inhibitor, and universal clopidogrel were the preferred strategy (willingness to pay threshold 50,000 USD/QALY) in 99.07% 0.04% and 0.89% of time, respectively.ConclusionsUsing both CYP2C19 GOF and LOF alleles to select antiplatelet therapy appears to be the preferred antiplatelet strategy over universal clopidogrel and universal alternative P2Y12 inhibitor therapy for ACS patients with PCI.
Martin Lof random and PA complete sets

A set A is Martin LL of random ii the class fAg does not have 0 1 measure 0. A set A is PA complete if one can compute relative to A a consistent and complete extension of Peano Arithmetic. It is shown that every Martin LL of random set either permits to solve the halting problem K or is not PA complete. This result implies a negative answer to the question of Ambos Spies and Ku cera whether there is a Martin LL of random set not above K which is also PA complete.
Real time state estimation with whole body multi contact dynamics: A modified UKF approach
Venue: 2016 IEEE RAS 16th International Conference on Humanoid Robots (Humanoids)

We present a real time state estimator applicable to whole body dynamics in contact rich behaviors. Our estimator is based on the Unscented Kalman Filter (UKF) with modifications that proved essential in the presence of strong contact non linearities combined with unavoidable model errors. Instead of the standard UKF weighting scheme, we use uniform weighting which is less susceptible to samples that violate unilateral constraints. We also develop a rich model of process noise including noise in system parameters, control noise, as well as a novel form of timing noise which makes the estimator more robust. The method is applied to an enhanced Darwin robot in walking as well as pseudo walking while lying on the floor. Estimation accuracy is quantified via leave one out cross validation, as well as comparisons to ground truth motion capture data which is not used by the estimator. A full update takes around 7 msec on a laptop processor. Furthermore we perform the computationally expensive prediction step (involving 210 forward dynamics evaluations in the MuJoCo simulator) while waiting for sensor data, and then apply the correction step as soon as sensor data arrive. This correction only takes 0.5 msec. Thus the estimator adds minimal latency to closed loop control, even though it handles the whole body robot dynamics directly, without resorting to any of the modeling shortcuts used in the past.
Development strategy and conceptual design of China Lead based Research Reactor

for nuclear waste transmutation since 2011, and China LEAd based Reactor (CLEAR) proposed by Institute of Nuclear Energy Safety Technology (INEST) is selected as the ADS reference reactor. In this paper, the development strategy and conceptual design of China Lead based Research Reactor are proposed. The Chinese ADS development program consists of three stages, and during the first stage, a 10 MW th lead based research reactor named CLEAR I will be built with subcritical and critical dual mode operation capability for validation of ADS transmutation system and lead cooled fast reactor technology. Major design principles of CLEAR I are oriented at technology feasibility, safety reliability, experiment flexibility and technology continuity. Followed by the development strategy and design principles, CLEAR I design options and conceptual design scenarios are presented.