nils-herrmann/clean_scirepeval huggingface dataset:
Receptance coupling of multi subsystem connected via a wedge mechanism with application in the position dependent dynamics of ballscrew drives

An accurate model of the feed drive's high order position dependent dynamics is crucial for the analysis and controller design of a high performance machine tool. In this paper, a new dynamic substructuring condition multi subsystem connected via a wedge mechanism is introduced, which is originated from the ballscrew nut dynamic coupling interface. Receptance coupling equations were derived for the condition, and a dynamic modeling approach is developed for the ballscrew drive system based on the equations. The developed model accounts for the ballscrew's rotational and axial flexibilities and the dynamic couplings among these flexibilities and that of the sliding component. The model explicitly describes the dynamics variation with respect to the table position, and is particularly suitable for sensitivity based analysis. Based on the model, the position dependent dynamics of an example ballscrew drive was analyzed, by using the frequencies distribution, the modal shape, and especially the sensitivity of the frequency response functions with respect to the table position.
Molecular Biology and Clinical Mitigation of Cancer Treatment Induced Neuropathy
Venue: Clinical Medicine Insights. Oncology

Disruption of microtubule function is the antitumor mechanism of several classes of drugs used to treat cancer today. However, the significant beneficial effect on tumor outcomes is frequently counterbalanced by neurotoxic complications. Despite an abundance of scientific data, our understanding of the biological mechanisms underlying this toxic reaction remains unclear, further hindering attempts to identify and develop effective preventive strategies. The primary goals of this review are to: (1) provide insight regarding the biology of the microtubule, (2) analyze the molecular and biochemical pathways that may be involved in the development of neurotoxicity, and (3) propose a unifying concept linking drug induced neuropathy, microtubule dysfunction, and vitamin D.
Optimum reference element selection for GNSS power inversion adaptive arrays

An improved algorithm for power inversion adaptive antenna arrays used in global navigation satellite systems (GNSS) receivers is proposed. Compared with traditional methods which select the reference element arbitrarily, the proposed method is capable of selecting the optimum reference element at signal acquisition stage. The criterion of the reference element selection is to maximise the acquisition test statistic results by developing the generalised likelihood ratio test detector. Monte Carlo simulation results show that the proposed method can improve the array performance significantly.
Impact of reference element selection on performance of power inversion adaptive arrays
Venue: 2016 IEEE/ION Position, Location and Navigation Symposium (PLANS)

Antenna arrays with adaptive algorithms are widely used to provide anti jamming abilities for Global Navigation Satellite System (GNSS) receivers, among which Power Inversion (PI) algorithm is attractive for suppression of jammers before de spreading of signals and simplicity for implementation. Most of previous works either selected the reference element arbitrarily or naturally selected the center element of the array geometry as reference. In this paper, we studied the effect of reference element selection on the performance of the adaptive array receivers. The results show that although the selection of reference element has negligible effects on interference cancellation, it does affect the array gain in the direction of desired signal as well as the array output signal to interference plus noise ratio (SINR) When the optimal reference element is selected, it will give more than 30% improvement in terms of available angular region under no SNR loss condition over arbitrary reference element selection.
NoSQL schema evolution and big data migration at scale
Venue: 2016 IEEE International Conference on Big Data (Big Data)

This paper explores scalable implementation strategies for carrying out lazy schema evolution in NoSQL data stores. For decades, schema evolution has been an evergreen in database research. Yet new challenges arise in the context of cloud hosted data backends: With all database reads and writes charged by the provider, migrating the entire data instance eagerly into a new schema can be prohibitively expensive. Thus, lazy migration may be more cost efficient, as legacy entities are only migrated in case they are actually accessed by the application. Related work has shown that the overhead of migrating data lazily is affordable when a single evolutionary change is carried out, such as adding a new property. In this paper, we focus on long term schema evolution, where chains of pending schema evolution operations may have to be applied. Chains occur when legacy entities written several application releases back are finally accessed by the application. We discuss strategies for dealing with chains of evolution operations, in particular, the composition into a single, equivalent composite migration that performs the required version jump. Our experiments with MongoDB focus on scalable implementation strategies. Our lineup further compares the number of write operations, and thus, the operational costs of different data migration strategies.
The profitability of pairs trading strategies: distance, cointegration and copula methods

We perform an extensive and robust study of the performance of three different pairs trading strategies the distance, cointegration and copula methods on the entire US equity market from 1962 to 2014 with time varying trading costs. For the cointegration and copula methods, we design a computationally efficient two step pairs trading strategy. In terms of economic outcomes, the distance, cointegration and copula methods show a mean monthly excess return of 91, 85 and 43 bps (38, 33 and 5 bps) before transaction costs (after transaction costs) respectively. In terms of continued profitability, from 2009, the frequency of trading opportunities via the distance and cointegration methods is reduced considerably, whereas this frequency remains stable for the copula method. Further, the copula method shows better performance for its unconverged trades compared to those of the other methods. While the liquidity factor is negatively correlated to all strategies' returns, we find no evidence of their correlation to market excess returns. All strategies show positive and significant alphas after accounting for various risk factors. We also find that in addition to all strategies performing better during periods of significant volatility, the cointegration method is the superior strategy during turbulent market conditions.
On the Profitability of Optimal Mean Reversion Trading Strategies

We study the profitability of optimal mean reversion trading strategies in the US equity market. Different from regular pair trading practice, we apply maximum likelihood method to construct the optimal static pairs trading portfolio that best fits the Ornstein Uhlenbeck process, and rigorously estimate the parameters. Therefore, we ensure that our portfolios match the mean reverting process before trading. We then generate contrarian trading signals using the model parameters. We also optimize the thresholds and the length of in sample period by multiple tests. In nine good pair examples, we can see that our pairs exhibit high Sharpe ratio (above 1.9) over the in sample period and out of sample period. In particular, Crown Castle International Corp. (CCI) and HCP, Inc. (HCP) achieve a Sharpe ratio of 2.326 during in sample period and a Sharpe ratio of 2.425 in out of sample test. Crown Castle International Corp. (CCI) and Realty Income Corporation (O) achieve a Sharpe ratio of 2.405 and 2.903 respectively during in sample period and out of sample period.
Healthcare Staff Wellbeing, Burnout, and Patient Safety: A Systematic Review
Venue: PloS one

To determine whether there is an association between healthcare professionals' wellbeing and burnout, with patient safety. Design Systematic research review.  (1806 to July 2015) Medline (1946 to July 2015) Embase (1947 to July 2015) and Scopus (1823 to July 2015) were searched, along with reference lists of eligible articles.  patient safety, in healthcare staff populations.  Forty six studies were identified. Sixteen out of the 27 studies that measured wellbeing found a significant correlation between poor wellbeing and worse patient safety, with six additional studies finding an association with some but not all scales used, and one study finding a significant association but in the opposite direction to the majority of studies. Twenty one out of the 30 studies that measured burnout found a significant association between burnout and patient safety, whilst a further four studies found an association between one or more (but not all) subscales of the burnout measures employed, and patient safety.  Poor wellbeing and moderate to high levels of burnout are associated, in the majority of studies reviewed, with poor patient safety outcomes such as medical errors, however the lack of prospective studies reduces the ability to determine causality. Further prospective studies, research in primary care, conducted within the UK, and a clearer definition of healthcare staff wellbeing are needed.  This review illustrates the need for healthcare organisations to consider improving employees' mental health as well as creating safer work environments when planning interventions to improve patient safety.
Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial.
Venue: American journal of obstetrics and gynecology

Preterm birth is the leading cause of neonatal death and handicap in survivors. Although twins are found in 1.5% of pregnancies they account for about 25% of preterm births. Randomized controlled trials in singleton pregnancies reported that the prophylactic use of progestogens, cervical cerclage and cervical pessary reduce significantly the rate of early preterm birth. In twin pregnancies, progestogens and cervical cerclage have been shown to be ineffective in reducing preterm birth.  The objective of this study was to test the hypothesis that the insertion of a cervical pessary in twin pregnancies would reduce the rate of spontaneous early preterm birth.  This was a multicenter, randomized controlled trial in unselected twin pregnancies of cervical pessary placement from 20(+0) 24(+6) weeks' gestation until elective removal or delivery vs. expectant management. Primary outcome was spontaneous birth <34 weeks. Secondary outcomes included perinatal death and a composite of adverse neonatal outcomes (intraventricular haemorrhage, respiratory distress syndrome, retinopathy of prematurity or necrotizing enterocolitis) or need for neonatal therapy (ventilation, phototherapy, treatment for proven or suspected sepsis, or blood transfusion) Analysis was by intention to treat.   A total of 1,180 (56.0% of the 2,107 eligible women agreed to take part in the trial; 590 received cervical pessary and 590 had expectant management. Two of the former and one of the latter were lost to follow up. There were no significant differences between the pessary and control groups in rates of spontaneous birth <34 weeks (13.6% vs. 12.9% relative risk 1.054, 95% confidence interval [CI] 0.787 1.413; p=0.722) perinatal death (2.5% vs. 2.7% relative risk 0.908, 95% CI 0.553 1.491; p=0.702) adverse neonatal outcome (10.0 vs. 9.2% relative risk 1.094, 95% CI 0.851 1.407; p=0.524) or neonatal therapy (17.9% vs. 17.2% relative risk 1.040, 95% CI 0.871 1.242; p=0.701) A post hoc subgroup analysis of 214 women with short cervix =25 mm) showed no benefit from the insertion of a cervical pessary.  In women with twin pregnancy, routine treatment with cervical pessary does not reduce the rate of spontaneous early preterm birth.
Using a CBT approach to manage low back pain.
Venue: Nursing times

Low back pain is not only commonplace the world over, but also costly to treat. A training programme was developed so health professionals from many different specialties, from nursing to occupational health, can have a positive impact on patients with the condition, easing their disability and consequently also, the financial burden on healthcare institutions and systems. This article describes the programme and outlines how NHS nurses can train to use the programme no matter where they are based.
Optimized and Prioritized Test Paths Generation from UML Activity Diagram using Firefly Algorithm

Due to limited resources and challenging time schedule, software testing is usually performed in pressure to assure the fulfilment of the software requirements. Test case generation is a crucial activity of the software testing phase. Testing of all paths from Control Flow Graph is not feasible in software testing, due to limited time and cost. Generation of optimized test paths is a challenging part of the software testing process. In this paper, a new technique to obtain the optimized test paths from activity diagram designed through Unified Modeling Language is demonstrated. A modified algorithm called as Firefly algorithm is used to obtain the critical paths. A case study of air flight check in is taken as a case study to explain the proposed approach. Paths are prioritized based on Information Flow Metric and their cyclomatic complexity. Obtained optimized paths have no redundancy and produced the better results.
Hardware Security Challenges Beyond CMOS: Attacks and Remedies
Venue: 2016 IEEE Computer Society Annual Symposium on VLSI (ISVLSI)

The globalization of Integrated Circuits (ICs) supply chain has raised security concerns on how to ensure the integrity and the trustworthiness of fabricated circuits. While existing attack and protection methods are developed for CMOS based circuits, the introduction of emerging transistors acts as a double sided sword. The usage of emerging devices introduces new security issues which the attackers can leverage to launch hardware attacks. On the other hand, the unique properties of emerging devices also provides a great opportunity for defenders to develop innovative hardware security primitives and to construct resilient hardware platforms for cybersecurity. In this paper, we will summarize the previous work in both directions, attacks and remedies with a focus on the authors' previous work in this domain. We will also discuss the research trends so that the emerging devices can better help secure our computing systems, besides their roles in extending the Moore's Law.
Recommendations on screening for colorectal cancer in primary care
Venue: Canadian Medical Association Journal

340 CMAJ, March 15, 2016, 188(5) (c)2016 8872147 Canada Inc. or its licensors Colorectal cancer is the second most common cause of cancer related death in men and the third most common in women;1 the lifetime probabilities of dying from colorectal cancer among men and women are 3.5% and 3.1% respectively.2 Although the burden of colorectal cancer varies across Canada,3 it is estimated that 25 000 Canadians received a diagnosis of colorectal cancer in 2015 (incidence 49 per 100 000 population) and that 9300 will die from the disease (mortality 17 per 100 000).1 The incidence and mortality of colorectal cancer are low until middle age and rise rapidly thereafter  is the ration ale for screening programs that aim to reduce deaths due to colorectal cancer by detecting and removing polyps and/or early stage colorectal cancers. Implementation of organized screening programs in some Canadian provinces has been associated with an increase in the number of individuals screened,6 and other provinces are in the process of implementing such programs (Appendix 1, available at www.cmaj.ca/lookup/ suppl/doi:10.1503/cmaj.151125/ /DC1) Currently, all Canadian programs recommend screening with guaiac fecal occult blood testing (gFOBT) or fecal immunochemical testing (FIT) This guideline presents recommendations for screening for colorectal cancer in asymptomatic adults aged 50 years and older who are not at high risk for colorectal cancer, and it updates previous Canadian Task Force on Preventive Health Care recommendations from 2001.7 The 2001 guideline recommended annual or biennial FOBT (grade A recommendation) and flexible sigmoidoscopy every five years (grade B recommendation) in asymptomatic people older than 50 years. The guideline did not recommend whether these screening modalities should be used alone or in combination (grade C),7,8 or whether to include or exclude colonoscopy as an initial screening test for colorectal cancer. Given the major changes in technology and practice since 2001, the guideline has been updated based on the most recent data available to provide guidance for primary care practitioners on different screening tests, screening intervals and recommended ages to start and stop screening.
The Primary Care PTSD Screen for DSM 5 (PC PTSD 5) Development and Evaluation Within a Veteran Primary Care Sample
Venue: Journal of General Internal Medicine

ABSTRACTBACKGROUNDPosttraumatic Stress Disorder (PTSD) is associated with increased health care utilization, medical morbidity, and tobacco and alcohol use. Consequently, screening for PTSD has become increasingly common in primary care clinics, especially in Veteran healthcare settings where trauma exposure among patients is common.OBJECTIVEThe objective of this study was to revise the Primary Care PTSD screen (PC PTSD) to reflect the new Diagnostic and Statistical Manual of Mental Disorders (DSM 5) criteria for PTSD (PC PTSD 5) and to examine both the diagnostic accuracy and the patient acceptability of the revised measure.DESIGNWe compared the PC PTSD 5 results with those from a brief psychiatric interview for PTSD. Participants also rated screening preferences and acceptability of the PC PTSD 5.PARTICIPANTSA convenience sample of 398 Veterans participated in the study (response rate 41 Most of the participants were male, in their 60s, and the majority identified as non Hispanic White.MEASURESThe PC PTSD 5 was used as the screening measure, a modified version of the PTSD module of the MINI International Neuropsychiatric Interview was used to diagnose DSM 5 PTSD, and five brief survey items were used to assess acceptability and preferences. RESULTSThe PC PTSD 5 demonstrated excellent diagnostic accuracy (AUC 0.941; 95 C.I. 0.912 0.969) Whereas a cut score of 3 maximized sensitivity (k[1] 0.93; SE .041; 95 C.I. 0.849 1.00) a cut score of 4 maximized efficiency (k[0.5] 0.63; SE 0.052; 95 C.I. 0.527 0.731) and a cut score of 5 maximized specificity (k[0] 0.70; SE 0.077; 95 C.I. 0.550 0.853) Patients found the screen acceptable and indicated a preference for administration by their primary care providers as opposed to by other providers or via self report.CONCLUSIONSThe PC PTSD 5 demonstrated strong preliminary results for diagnostic accuracy, and was broadly acceptable to patients.
An initial psychometric assessment of an ICD 11 based measure of PTSD and complex PTSD (ICD TQ) Evidence of construct validity.
Venue: Journal of anxiety disorders

Among the conditions following exposure to traumatic life events proposed by ICD 11 are Posttraumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD) The primary aim of this study was to provide an assessment of the reliability and validity of a newly developed self report measure of ICD 11 PTSD and CPTSD: the ICD 11 Trauma Questionnaire (ICD TQ) Participants in this study were a sample of individuals who were referred for psychological therapy to a National Health Service (NHS) trauma centre in Scotland (N=193) Participants completed the ICD TQ and measures of traumatic life events, DSM 5 PTSD, emotion dysregulation, self esteem, and interpersonal difficulties. Confirmatory factor analysis results supported the factorial validity of the ICD TQ with results in line with ICD 11 proposals. The ICD TQ demonstrated satisfactory internal reliability, and correlation results indicated that the scale exhibited convergent and discriminant validity. Current results provide initial support for the psychometric properties of this initial version of the ICD TQ. Future theoretical and empirical work will be required to generate a final version of the ICD TQ that will match the diagnostic structure of PTSD and CPTSD when ICD 11 is published.
Emergent self organization in active materials.
Venue: Current opinion in cell biology

Biological systems exhibit large scale self organized dynamics and structures which enable organisms to perform the functions of life. The field of active matter strives to develop and understand microscopically driven nonequilibrium materials, with emergent properties comparable to those of living systems. This review will describe two recently developed classes of active matter systems, in which simple building blocks self propelled colloidal particles or extensile rod like particles self organize to form macroscopic structures with features not possible in equilibrium systems. We summarize the recent experimental and theoretical progress on each of these systems, and we present simple descriptions of the physics underlying their emergent behaviors.
Cell phone based health education messaging improves health literacy.
Venue: African health sciences

The ubiquity of cell phones, which allow for short message service (SMS) provides new and innovative opportunities for disease prevention and health education.  To explore the use of cell phone based health education SMS to improve the health literacy of community residents in China.  A multi stage random sampling method was used to select representative study communities and participants 18 years old. Intervention participants were sent health education SMSs once a week for 1 year and controls were sent conventional, basic health education measures. Health literacy levels of the residents before and after the intervention were evaluated between intervention and control groups.  Public health literacy scores increased 1.5 points, from 61.8 to 63.3, after SMS intervention for 1 year (P<0.01) the increase was greater for males than females (2.01 vs. 1.03; P<0.01) and for Shenzhen local residents than non permanent residents (2.56 vs. 1.14; P<0.01) The frequency of high health literacy scores was greater for the intervention than control group (22.03% to 30.93% vs. 22.07% to 20.82% With health literacy as a cost effective index, the cost effectiveness per intervention was 0.54.  SMS may be a useful tool for improving health literacy.
Toward the full and proper implementation of Jordan's Principle: An elusive goal to date.
Venue: Paediatrics child health

First Nations children experience service delays, disruptions and denials due to jurisdictional payment disputes within and between federal and provincial/territorial governments. The House of Commons sought to ensure First Nations children could access government services on the same terms as other children when it unanimously passed a private members motion in support of Jordan's Principle in 2007. Jordan's Principle states that when a jurisdictional dispute arises regarding public services for a First Nations child that are otherwise available to other children, the government of first contact pays for the service and addresses payment disputes later. Unfortunately, the federal government adopted a definition of Jordan's Principle that was so narrow (complex medical needs with multiple service providers) that no child ever qualified. This narrow definition has been found to be unlawful by the Federal Court of Canada and the Canadian Human Rights Tribunal. The present commentary describes Jordan's Principle, the legal cases that have considered it and the implications of those decisions for health care providers.