nils-herrmann/clean_scirepeval huggingface dataset:
In-vivo kinematic assessment of alloplastic temporomandibular joint replacements by means of helical axis: A cohort study with historical control.
Venue: Journal of biomechanics

Alloplastic total temporomandibular joint replacement (TJR) is a surgical procedure used to restore normal mandibular function when conservative therapies fail. The instantaneous helical axis (HA), is a mathematical model used to visualize globally rigid body kinematics. It can be applied to mandibular motion for quantification of movement patterns and irregularities. Aim of this study was to analyze HA pathways in subjects with unilateral and bilateral TJR and compare them to a control group. An optoelectronic system was employed to track mouth opening/closing cycles (n = 3) of 15 patients (7 operated unilaterally, 8 bilaterally, 11 F, aged 24-72) and 12 controls (6 F, aged 23-40). HA position in space was determined for 30 equally-distributed steps of the observed movement. Total mandibular rotation around HA (Φtot) and total translation along HA (Ttot) were determined. Angles between HA and the anatomical coordinate system of the head (θx, θy, θz); global fluctuation of HA spatial orientation (θe), distance between condylar center (CP) and HA (dCP) and its projections on the axes (xdCP, ydCP, zdCP) were calculated. Overall, Φtot was larger in controls than in bilaterally operated subjects (p = 0.002, p = 0.003) and θz was larger in unilaterally operated subjects than in controls (p = 0.004) and bilaterally operated subjects (p = 0.002, p = 0.024). During opening, θe¯ was smaller in controls than in unilaterally operated subjects (p = 0.01). The distance dCP was smaller for alloplastic joints than for controls (p < 0.01 overall). In conclusion, mandibular HA pathways in patients with TJR differ significantly from controls in terms of spatial location and variability.
Dynamic foot morphology explained through 4D scanning and shape modeling.
Venue: Journal of biomechanics

A detailed understanding of foot morphology can enable the design of more comfortable and better fitting footwear. However, foot morphology varies widely within the population, and changes dynamically as the foot is loaded during stance. This study presents a parametric statistical shape model from 4D foot scans to capture both the inter- and intra-individual variability in foot morphology. Thirty subjects walked on a treadmill while 4D scans of their right foot were taken at 90 frames-per second during stance phase. Each subject's height, weight, foot length, foot width, arch length, and sex were also recorded. The 4D scans were all registered to a common high-quality foot scan, and a principal component analysis was done on all processed 4D scans. Elastic-net linear regression models were built to predict the principal component scores, which were then inverse transformed into 4D scans. The best performing model was selected with leave-one-out cross-validation. The chosen model predicts foot morphology across stance phase with a root-mean-square error of 5.2 ± 2.0 mm and a mean Hausdorff distance of 25.5 ± 13.4 mm. This study shows that statistical shape modeling can be used to predict dynamic changes in foot morphology across the population. The model can be used to investigate and improve foot-footwear interaction, allowing for better fitting and more comfortable footwear.
Functional data analysis reveals asymmetrical crank torque during cycling performed at different exercise intensities.
Venue: Journal of biomechanics

Pedaling asymmetry is claimed as a factor of influence on injury and performance. However, the evidence is still controversial. Most previous studies determined peak torque asymmetries, which in our understanding does not consider the pattern of movement like torque profiles. Here we demonstrate that asymmetries in pedaling torque at different exercise intensities can be better described when the torque profiles are considered using functional analysis of variance than when only the peak values are analyzed. We compared peak torques and torque curves recorded while cyclists pedaled at submaximal intensities of 60%, 80%, and 95% of the maximal power output and compared data between the preferred and non-preferred legs. ANOVA showed symmetry or rather no difference in the amount of peak torque between legs, regardless of pedaling intensity. FANOVA, on the other hand, revealed significant asymmetries between legs, regardless of cycling intensity, apparently for different sections of the cycle, however, not for peak torque, either. We conclude that pedaling asymmetry cannot be quantified solely by peak torques and considering the analysis of the entire movement cycle can more accurately reflect the biomechanical movement pattern. Therefore, FANOVA data analysis could be an alternative to identify asymmetries. A novel approach as described here might be useful when combining kinetics assessment with other approaches like EMG and kinematics and help to better understand the role of pedaling asymmetries for performance and injury risks.
Biodegradable performance of PLA stents affected by geometrical parameters: The risk of fracture and fragment separation.
Venue: Journal of biomechanics

Biodegradable endovascular stents have been claimed to be reliable candidates for implantation devices used in treating cardiovascular diseases since they reduce the long-term side effects on the human biological system. It is aimed in this study to investigate the effect of geometrical parameters on the degradation behavior of poly (lactic acid) stents in term of strut fracture and fragment separation. In this regard, various structural geometry of the PLA stents was simulated in a stenosed artery using finite element method. For predicting the PLA degradation, a computational model was prepared by which the influence of stents design on their radial strength and fracture was investigated. Using a laboratory-scale designed bioreactor, the PLA fibers degradation was evaluated to calibrate the material parameters and verify the simulation method. Simulation results demonstrated that the geometrical parameters, i.e., number of struts, curves radius and stent cells shape, strongly affect the degradation behavior. The results indicated that the smooth design leads to uniform degradation in the whole stent and decreases the danger of stent fragments separation. It was shown that the maximum degradation rate of the stents with rounded curves was one-third of the models with sharp corners.
Exploring the influence of impact severity and posture on vertebral joint mechanics in an in-vitro porcine model.
Venue: Journal of biomechanics

To date, no in vitro studies have been conducted to explore lumbar soft tissue injury potential and altered mechanical properties from exposure to impact forces. After a motor vehicle collision (MVC), the cause of reported acute onset low back pain is difficult to associate with potential soft tissue strain injury sites including the facet joint and innervated facet joint capsule ligament (FJC). Thus, the purpose of this investigation was to quantify intervertebral anterior-posterior (AP) translation and facet joint capsule strain under varying postures and impact severities. Seventy-two porcine spinal units were exposed to three levels of impact severity (4 g, 8 g, 11 g), and posture (Neutral, Flexion, Extension). Impacts were applied using a custom-built impact track that replicated parameters experienced in low to moderate speed rear-end MVCs. Flexion-extension and anterior-posterior shear neutral zone testing were completed prior to impact. AP intervertebral translation and the strain tensor of the facet capsule ligament were measured during impacts. A significant main effect of collision severity was observed for peak AP intervertebral translation (4 g-2.8 ±0.53 mm; 8 g-6.4 ±2.9 mm; 11 g-8.3 ±0.45 mm) and peak FJC shear strain (2.37% strain change from 4 g to 11 g impact severity). Despite observed main effects of impact severity, no influence of posture was observed. This lack of influence of posture and small FJC strain magnitudes suggest that the FJC does not appear to undergo injurious or permanent mechanical changes in response to low-to-moderate MVC impact scenarios.
Prediction of human male trunk mass distribution using anthropometric measurements: A feasibility study.
Venue: Journal of biomechanics

The current study proposes a new method to predict the body shape and mass distribution of the trunk (Tl-L5) of a human male using 15 anthropometric measurements acquired at various locations of the body. Trunk cross-sectional images adopted from the Visible Human male project database were segmented into fat, bone, and lean tissue. Assuming that all male subjects have similar cross-sectional composition at a given body height percentile, areas of the segmented cross-sectional images of the Visible Human male along the trunk were scaled to match those of the predicted body shape. The trunk mass distribution of the target subject can then be computed using the density values of fat, bone, and lean tissue. Comparison of the predicted body shape circumference with ground truth values measured using digital and actual measurements yielded maximum mean error of 13.3 mm and 30.3 mm, respectively. The accuracy of the image segmentation was evaluated, and the results showed a high Jaccard index (>0.95). The proposed method was able to predict the trunk mass distribution of two volunteers with a maximum deviation of 384 g at T4 level and a minimum deviation of 12 g at L4 level and the corresponding centers of mass fell within the experimental data at most levels. Thus, our method can be considered as a feasible option to calculate subject-specific trunk mass distribution.
The influence of cognitive load on balance control during steady-state walking.
Venue: Journal of biomechanics

For an individual to successfully walk, they must maintain control of their dynamic balance. However, situations that require increased cognitive attention may impair an individual's ability to actively control their balance. While dual-task studies have analyzed walking-while-talking conditions, few studies have focused specifically on the influence of cognitive load on balance control. The purpose of this study was to assess how individuals prioritize their cognitive resources and control dynamic balance during dual-task conditions of varying difficulty. Young healthy adults (n = 15) performed two single-task conditions (spelling-while-standing and treadmill walking with no cognitive load) and three dual-task conditions (treadmill walking with increasing cognitive load: attentive listening and spelling short and long words backwards). Cognitive performance did not change between the single- and dual-task as measured by spelling percent error and response rate (p = 0.300). Balance control, assessed using the range of whole-body angular momentum, did not change between the no load and listening conditions, but decreased during the short and long spelling conditions (p < 0.001). These results highlight that in young adults balance control decreases during dual-task treadmill walking with increased cognitive loads, but their cognitive performance does not change. The decrease in balance control suggests that participants prioritized cognitive performance over balance control during these dual-task walking conditions. This work offers additional insight into the automaticity of walking and task-prioritization in healthy young individuals and provides the basis for future studies to determine differences in neurologically impaired populations.
Effect of trunk muscles fatigue on plantar pressure distribution in novice runners.
Venue: Journal of biomechanics

During running, trunk muscles act to sufficiently contribute to the energy generation and transmission of the body parts. Improper function of trunk muscles affects running mechanics adversely and could result in altered lower limb energetics. The aim of this study was to examine the effects of trunk muscles fatigue on plantar pressure distribution in novice runners. 46 novice heel-to-toe runners (26 female and 20 male) ran in 3.3 m/s before and after the trunk muscles fatigue along the plantar pressure measuring device. Then, participants performed trunk muscles fatigue protocol. Trunk muscles fatigue protocol consisted of four consecutive cycles of seven exercises (1) rotating trunk with a medicine ball in sitting position, 2) prone static torso extension with a medicine ball, 3) rotate lower torso with a medicine ball in supine position, 4) incline sit-ups with a weight plate, 5) lateral side binding with a weight plate, 6) rotating lumbar extension with weighted plate, and 7) standing trunk rotation with weighted pulley resistant. After trunk muscles fatigue, increases in loading of lesser toes (p = 0.001, ES = 0.379), fourth (p = 0.001, ES = 0.474) and fifth metatarsals (p = 0.004, ES = 0.173) and medial and lateral heel (p = 0.018,0.001, ES = 0.118,0.427) were observed. Also, foot progression angle (p = 0.001, ES = 392) and relative time of initial contact phase (p = 0.003, ES = 0.182) decreased. The trunk muscles fatigue could alter the plantar pressure distribution pattern. Novice runners should consider strengthening of the trunk region muscles to avoid trunk muscles strength reduction-related changes in running mechanics.
Influence of sensor mass and adipose tissue on the mechanomyography signal of elbow flexor muscles.
Venue: Journal of biomechanics

Mechanomyography (MMG) is a non-invasive technique that records muscle contraction using sensors positioned on the skin's surface. Therefore, it can have its signal attenuated due to the adipose tissue, directly influencing the results. This study evaluates the influence of different mass added to a sensor's assembly and the adipose tissue on MMG signals of elbow flexor muscles. Test protocol consisted of skinfold thickness measurement of 22 volunteers, followed by applying 2-3 s electrical stimulation for muscle contraction during the acquisition of MMG signals. MMG signals were processed in the time domain, using the average of the absolute amplitude, and expressed in gravity values (G), termed here as MMG(G). Tests occurred four times with different sensor masses. MMG data were processed and analyzed statistically using Friedman and Kruskal-Wallis tests to determine the differences between the MMG signals measured with different sensor masses. The Mann-Whitney analysis indicated differences in the MMG signals between groups with different skinfold thickness. MMG(G) signals suffered attenuation with increasing sensor mass (0.4416 G to 0.94 g; 0.3902 G to 2.64 g; 0.3762 G to 5.44 g; 0.3762 G to 7.14 g) and adipose tissue.
Feasibility of two-dimensional speckle-tracking echocardiography of aortic valve in patients with calcific aortic valve disease.
Venue: Journal of biomechanics

Calcific aortic valve (AV) disease is associated with increased stiffness and reduced motion of AV leaflets, has a progressive course, and can develop into aortic stenosis (AS). Our aim was to evaluate whether two-dimensional speckle-tracking echocardiography (STE) may be used for the assessment of AV stiffness. We applied STE to AV leaflets in patients with various degrees of degenerative changes of AV and measured strain as an absolute value of the radial deformation of AV leaflets. Deformation of AV expressed as averaged AV strain was greatest in patients with a normal AV (23.4 ± 6.4%), compared to those with aortic sclerosis (12.9 ± 3.2%), moderate-to-severe AS (11.9 ± 4%), and severe AS (10.9 ± 3.5%) (p < 0.01). A non-linear relationship and moderate correlation of AV strain with transvalvular hemodynamic parameters was observed. In patients with mild-to-moderate AS, the strain of AV leaflets also correlated negatively with AV calcification (r = -0.59, p = 0.008). Good inter-observer agreement was obtained for averaged AV strain with a coefficient of variation of 0.15 and an interclass correlation coefficient of 0.94 (p < 0.0001). In this study we demonstrated that deformation of AV leaflets as assessed by STE might be a potential method for a non-invasive evaluation of AV biomechanical properties and of the progression of calcific aortic disease. Further development of the two-dimensional speckle tracking technique specifically for valve structures is needed to enable a better quantification of leaflet deformation.
The ins and outs of dynamic balance during 90-degree turns in people with a unilateral transtibial amputation.
Venue: Journal of biomechanics

The ability to maintain balance when turning is essential to functional and independent living. Due to the lack of neuromuscular ankle control on the prosthetic side in people with a transtibial amputation (TTA), turning is likely more challenging. The purpose of this study was to quantify how people with TTA maintain dynamic balance during 90-degree turns made with the prosthesis on the inside and outside of the turn compared to people without amputation. Eight participants with TTA and eight age-, height-, and sex- matched non-amputee controls performed left and right 90-degree step turns at a self-selected speed. The primary outcomes were range of whole-body angular momentum and positive and negative contributions of six segment groups (head/trunk, pelvis, arms, and legs) to whole-body angular momentum during the continuation stride. Participants with TTA had greater range of frontal- and sagittal-plane whole-body angular momentum when turning with the prosthesis on the inside compared controls. They also had a greater range of whole-body angular momentum in all planes of motion when turning with the prosthesis on the inside compared to outside of the turn. The contributions for the head/trunk and inside and outside legs differed between groups and turns, suggesting altered interactions between segment momenta to compensate for the reduced contribution of the amputated leg. This study provides insight into possible training paradigms to reduce the high incidence of turn related falls in people with TTA and, potentially, ways to alter prosthetic function to promote balance control.
Sample size estimation for biomechanical waveforms: Current practice, recommendations and a comparison to discrete power analysis.
Venue: Journal of biomechanics

Testing a prediction is fundamental to scientific experiments. Where biomechanical experiments involve analysis of 1-Dimensional (waveform) data, sample size estimation should consider both 1D variance and hypothesised 1D effects. This study exemplifies 1D sample size estimation using typical biomechanical signals and contrasts this with 0D (discrete) power analysis. For context, biomechanics papers from 2018 and 2019 were reviewed to characterise current practice. Sample size estimation occurred in approximately 4% of 653 papers and reporting practice was mixed. To estimate sample sizes, common biomechanical signals were sourced from the literature and 1D effects were generated artificially using the open-source power1d software. Smooth Gaussian noise was added to the modelled 1D effect to numerically estimate the sample size required. Sample sizes estimated using 1D power procedures varied according to the characteristics of the dataset, requiring only small-to-moderate sample sizes of approximately 5-40 to achieve target powers of 0.8 for reported 1D effects, but were always larger than 0D sample sizes (from N + 1 to >N + 20). The importance of a priori sample size estimation is highlighted and recommendations are provided to improve the consistency of reporting. This study should enable researchers to construct 1D biomechanical effects to address adequately powered, hypothesis-driven, predictive research questions.
The metabolic and mechanical consequences of altered propulsive force generation in walking.
Venue: Journal of biomechanics

Older adults walk with greater metabolic energy consumption than younger for reasons that are not well understood. We suspect that a distal-to-proximal redistribution of leg muscle demand, from muscles spanning the ankle to those spanning the hip, contributes to greater metabolic energy costs. Recently, we found that when younger adults using biofeedback target smaller than normal peak propulsive forces (FP), they do so via a similar redistribution of leg muscle demand during walking. This alludes to an experimental paradigm that emulates characteristics of elderly gait independent of other age-related changes relevant to metabolic energy cost. Thus, our purpose was to quantify the metabolic and limb- and joint-level mechanical energy costs associated with modulating propulsive forces during walking in younger adults. Walking with larger FP increased net metabolic power by 47% (main effect, p = 0.001), which was accompanied by small by relatively uniform increases in hip, knee, and ankle joint power and which correlated with total joint power (R2 = 0.151, p = 0.019). Walking with smaller FP increased net metabolic power by 58% (main effect, p < 0.001), which was accompanied by higher step frequencies and increased total joint power due to disproportionate increases in hip joint power. Increases in hip joint power when targeting smaller than normal FP accounted for more than 65% of the variance in the measured changes in net metabolic power. Our findings suggest that walking with a diminished push-off exacts a metabolic penalty because of higher step frequencies and more total limb work due to an increased demand on proximal leg muscles.
AFM-based indentation method for measuring the relaxation property of living cells.
Venue: Journal of biomechanics

Probing the mechanical properties of cells is critical for understanding their deformation behaviors and biological functions. Although some methods have been proposed to characterize the elastic properties of cells, it is still difficult to measure their time-dependent properties. This paper investigates the use of atomic force microscope (AFM) to determine the reduced relaxation modulus of cells. In principle, AFM is hard to perform an indentation relaxation test that requires a constant indenter displacement during load relaxation, whereas the real AFM indenter displacement usually varies with time during relaxation due to the relatively small bending stiffness of its cantilever. We investigate this issue through a combined theoretical, computational, and experimental effort. A protocol relying on the choice of appropriate cantilever bending stiffness is proposed to perform an AFM-based indentation relaxation test of cells, which enables the measurement of reduced relaxation modulus with high accuracy. This protocol is first validated by performing nanoindentation relaxation tests on a soft material and by comparing the results with those from independent measurements. Then indentation tests of cartilage cells are conducted to demonstrate this method in determining time-dependent properties of living cells. Finally, the change in the viscoelasticity of MCF-7 cells under hyperthermia is investigated.