nils-herrmann/clean_scirepeval huggingface dataset:
Transient body sway characteristics during single-leg quiet stance in ballet dancers and young adults.
Venue: Journal of biomechanics

This study explored transient characteristics of body sway during single-leg quiet stance in young ballet dancers (n = 41) and young healthy adults (n = 58). We compared the groups in terms of center of pressure (CoP) parameters (CoP velocity and amplitude, averaged across the duration of the 30-s trial), and the transient characteristics of the corresponding parameters, which were expressed as relative differences between the 1st and 2nd, and the 1st and 3rd 10-second interval within the trial (DIF_21 and DIF_31, respectively). Ballet dancers exhibited superior quiet stance postural control (2/5 parameters), as well as different transient behavior (3/5 parameters for DIF_21, and none for DIF_31). Specifically, the ballet dancers reduced body sway more during the 2nd interval, resulting in lower DIF_21 for CoP velocity (total and anterior-posterior) and CoP amplitude (medial-lateral) (effect size = 0.42-0.54). The correlations between individual CoP parameters and the corresponding DIF_21 and DIF_31 were very small or trivial (r < 0.15), suggesting that the outcomes pertaining to transient characteristic of body sway within the trial (specifically DIF_21) could represent additional information regarding the postural control during quiet stance. Future studies or even re-analyses of existing data are desired to reveal whether the measures of transient characteristics of body sway have any additional clinical utility compared to traditional whole-trial analyses.
Do humans exploit the metabolic and mechanical benefits of arm swing across slow to fast walking speeds?
Venue: Journal of biomechanics

Humans naturally select conditions to minimize their net cost of transport (COT) during walking. One way to do this is by exploiting the mechanical benefit of arm swing which reduces whole-body rotation about the vertical axis and thus, minimizes the free vertical moment (FVM) that the foot applies to the ground. Humans appear to exploit these benefits of arm swing at speeds that are considered optimal, but we sought to determine if these benefits are conserved across slow to fast walking speeds. If true, arm swing may be a key feature that helps to minimize the net COT regardless of one's walking speed. We hypothesized that at all speeds, walking with arm swing would be less costly compared to walking without arm swing. As a secondary aim, we also explored if reductions in the peak FVM could explain the metabolic benefits of arm swing. Twenty-one young, healthy subjects walked with and without arm swing at speeds ranging from 0.50 to 2.00 m/s while we recorded metabolic, kinematic and kinetic data. At slow speeds (≤1.00 m/s), net COT was similar when walking with or without arm swing (p > 0.05). However, at intermediate and fast speeds (≥1.00 m/s), arm swing reduced the net COT by ~7-13% (all p's < 0.05). Additionally, peak FVM magnitudes decreased with arm swing, suggesting that it may partially explain the metabolic benefit of arm swing. Overall, we find that arm swing provides a net metabolic benefit during walking, but this benefit is constrained to intermediate and fast walking speeds.
In vitro and in silico testing of partially and fully bioresorbable vascular scaffold.
Venue: Journal of biomechanics

Coronary artery disease (CAD), one of the leading causes of death globally, occurs due to the growth of atherosclerotic plaques in the coronary arteries, causing lesions which restrict the flow of blood to the myocardium. Percutaneous transluminal coronary angioplasty (PTCA), including balloon angioplasty and coronary stent deployment is a standard clinical invasive treatment for CAD. Coronary stents are delivered using a balloon catheter inserted across the lesion. The balloon is inflated to a nominal pressure, opening the occluded artery, deploying the stent and improving the flow of blood to the myocardium. All stent manufacturers have to perform standard in vitro mechanical testing under different physiological conditions. In this study, partially and fully bioresorbable vascular scaffolds (BVS) from Boston Scientific Limited have been examined in vitro and in silico for three different test methods: inflation, radial compression and crush resistance. We formulated a material model for poly-L-lactic acid (PLLA) and implemented it into our in-house software tool. A comparison of the different experimental results is presented in the form of graphs showing displacement-force curves, diameter - load curves or diameter - pressure curves. There is a strong correlation between simulation and real experiments with a coefficient of determination (R2) > 0.99 and a correlation coefficient (R) > 0.99. This preliminary study has shown that in-silico tests can mimic the applicable ISO standards for mechanical in vitro stent testing, providing the opportunity to use data generated using in-silico testing to partially or fully replacing the mechanical testing required for regulatory submission.
Effect of age on the failure properties of human meniscus: High-speed strain mapping of tissue tears.
Venue: Journal of biomechanics

The knee meniscus is a soft fibrous tissue with a high incidence of injury in older populations. The objective of this study was to determine the effect of age on the failure behavior of human knee meniscus when applying uniaxial tensile loads parallel or perpendicular to the primary circumferential fiber orientation. Two age groups were tested: under 40 and over 65 years old. We paired high-speed video with digital image correlation to quantify for the first time the planar strains occurring in the tear region at precise time points, including at ultimate tensile stress, when the tissue begins losing load-bearing capacity. On average, older meniscus specimens loaded parallel to the fiber axis had approximately one-third less ultimate tensile strain and absorbed 60% less energy to failure within the tear region than younger specimens (p < 0.05). Older specimens also had significantly reduced strength and material toughness when loaded perpendicular to the fibers (p < 0.05). These age-related changes indicate a loss of collagen fiber extensibility and weakening of the non-fibrous matrix with age. In addition, we found that when loaded perpendicular to the circumferential fibers, tears propagated near the planes of maximum tensile stress and strain. Whereas when loaded parallel to the circumferential fibers, tears propagated oblique to the loading axis, closer to the planes of maximum shear stress and strain. Our experimental results can assist the selection of valid failure criteria for meniscus, and provide insight into the effect of age on the failure mechanisms of soft fibrous tissue.
Estimation of load conditions and strain distribution for in vivo murine tibia compression loading using experimentally informed finite element models.
Venue: Journal of biomechanics

The murine tibia compression model, is the gold standard for studying bone adaptation due to mechanical loading in vivo. Currently, a key limitation of the experimental protocol and associated finite element (FE) models is that the exact load transfer, and consequently the loading conditions on the tibial plateau, is unknown. Often in FE models, load is applied to the tibial plateau based on inferences from micro-computed tomography (μCT). Experimental models often use a single strain gauge to assess the three-dimensional (3D) loading state. However, a single strain gauge is insufficient to validate such FE models. To address this challenge, we develop an experimentally calibrated method for identifying the load application region on the tibial plateau based upon measurements from three strain gauges. To achieve this, axial compression was conducted on mouse tibiae (n=3), with strains gauges on three surfaces. FE simulations were performed to compute the strains at the gauge locations as a function of a variable load location. By minimising the error between experimental and FE strains, the precise load location was identified; this was found to vary between tibia specimens. It was further shown that commonly used FE loading conditions, found in literature, did not replicate the experimental strain distribution, highlighting the importance of load calibration. This work provides critical insights into how load is transferred to the tibial plateau. Importantly, this work develops an experimentally informed technique for loading the tibial plateau in FE models.
Improvement of clinical fracture healing - What can be learned from mechano-biological research?
Venue: Journal of biomechanics

The most significant predictors of reoperation following operative management of fractures are the presence of a third degree open fracture, remaining fracture gaps and a transverse fracture. However clinical studies provide no information regarding the involvement of various soft tissues or how the mechanical environment affects revascularisation and bone healing. Here the results of experimental and numerical mechano-biological studies on fracture healing are summarized to provide guidance toward clinical treatment of fractures. In experimental studies, isolated muscle crush appeared to only temporarily impair fracture healing, with no significant effect to the final bone healing, whereas a more severe muscle trauma significantly reduced callus formation and biomechanical properties of the healed bones. An intraoperative trauma can furthermore impede vascularization. Surgical removal of the haematoma or periosteum disturbs fracture healing. While reaming for intramedullary nailing reduced blood flow in the bone during the early phase of bone healing, it did not affect the stiffness or strength of the final bone healing. The optimal conditions for rapid vascularization and bone healing result from fracture fixation that minimizes shearing movements in the healing zone while allowing moderate compressive movements. Bone healing is increasingly delayed with increasing fracture gap size and critical-size defects do not heal sufficiently independent of the mechanical environment. The stiffness of fracture fixation systems like nails and external fixators applied in clinical treatments frequently display a too low stiffness, whereas plate systems often cause a too stiff fixation that suppresses bone healing.
Discrete element and finite element methods provide similar estimations for hip joint contact mechanics during walking gait.
Venue: Journal of biomechanics

Finite element analysis (FEA) provides a powerful approach for estimating the in-vivo loading characteristics of the hip joint during various locomotory and functional activities. However, time-consuming procedures, such as the generation of high-quality FE meshes and setup of FE simulation, typically make the method impractical for rapid applications which could be used in clinical routine. Alternatively, discrete element analysis (DEA) has been developed to quantify mechanical conditions of the hip joint in a fraction of time compared to FEA. Although DEA has proven effective in the estimation of contact stresses and areas in various complex applications, it has not yet been well characterised by its ability to evaluate contact mechanics for the hip joint during gait cycle loading using data from several individuals. The objective of this work was to compare DEA modelling against well-established FEA for analysing contact mechanics of the hip joint during walking gait. Subject-specific models were generated from magnetic resonance images of the hip joints in five asymptomatic subjects. The DEA and FEA models were then simulated for 13 loading time-points extracted from a full gait cycle. Computationally, DEA was substantially more efficient compared to FEA (simulation times of seconds vs. hours). The DEA and FEA methods had similar predictions for contact pressure distribution for the hip joint during normal walking. In all 13 simulated loading time-points across five subjects, the maximum difference in average contact pressures between DEA and FEA was within ±0.06 MPa. Furthermore, the difference in contact area ratio computed using DEA and FEA was less than ±6%.
Assessment of turning performance and muscle coordination in individuals post-stroke.
Venue: Journal of biomechanics

Turning is an important activity of daily living and often compromised post-stroke. The fall rate for individuals post-stroke while turning is nearly four times as high compared to healthy adults, with most falls resulting in injury. Thus, there is a need for evidence-based rehabilitation targets to improve turning performance for individuals post-stroke. To produce well-coordinated movements, muscles can be organized into muscle modules (i.e., groups of co-excited muscles). Post-stroke these modules can be merged, leading to impaired muscle coordination and walking performance. However, the relationship between impaired coordination and turning performance is not well understood. Thus, the purpose of this study was to analyze the influence of impaired muscle coordination (i.e., merged modules) on turning performance (i.e., time and number of steps required to complete a turn, and smoothness and balance control during the turn). Individuals post-stroke and healthy controls performed three tasks including overground straight-line walking, a 90-degree turn, and a 180-degree turn. The number of muscle modules during straight-line walking were determined using non-negative matrix factorization. During 180-degree turning, those with two modules took longer to turn, used more steps and had less smooth movement. Those with reduced module complexity exhibited diminished balance control during both 90-degree and 180-degree turning. These results suggest obtaining independent modules should be an important aim in locomotor therapies aimed at improving turning performance. In addition, the time it takes to complete a 180-degree turn may provide useful clinical insight into impaired muscle coordination post-stroke.
Does forced or compensated turnout lead to musculoskeletal injuries in dancers? A systematic review on the complexity of causes.
Venue: Journal of biomechanics

Injury prevalence in dancers is high, and misaligned turnout (TO) is claimed to bear injury risk. This systematic review aimed to investigate if compensating or forcing TO leads to musculoskeletal injuries. A systematic literature review was conducted according to the PRISMA Guidelines using the databases of PubMed, Embase, Emcare, Web of Science, Cochrane Library, Academic Search Premier, and ScienceDirect. Studies investigating the relationship between compensated or forced TO and injuries in all genders, all ages, and levels of dancers were included. Details on misaligned TO measurements and injuries had to be provided. Screening was performed by two researchers, data extraction and methodological quality assessment executed by one researcher and checked by another. 7 studies with 1293 dancers were included. Methodological quality was low due to study designs and a general lack of standardised definition of pathology and methods of assessment of misaligned TO. The studies investigating the lower extremities showed a hip-focus only. Non-hip contributors as well as their natural anatomical variations were not accounted for, limiting the understanding of injury mechanisms underlying misaligned TO. As such no definite conclusions on the effect of compensating or forcing TO on musculoskeletal injuries could be made. Total TO is dependent on complex motion cycles rather than generalised (hip) joint dominance only. Objective dual assessment of maximum passive joint range of motion through 3D kinematic analysis in combination with physical examination is needed to account for anatomical variations, locate sites prone to (overuse)injury, and investigate underlying injury mechanisms.
Non-amputated limb muscle coordination of unilateral transfemoral amputees.
Venue: Journal of biomechanics

Unilateral transfemoral amputees rely heavily on non-amputated limb muscles to regulate the prosthetic gait. In this study, we compared the non-amputated limb muscle coordination of eight unilateral transfemoral amputees to eight able-bodied controls. Inverse dynamics approach was conducted via a musculoskeletal model to obtain lower limb joint moments and muscle forces. In addition to the muscle forces at the instants of peak joint moments and the maximum muscle forces, the peak joint moments of the lower limbs were also investigated. The results showed that there were significant differences of muscle forces between the non-amputated limbs and the controls at the instant of peak hip extension moment, although the peak hip extension moments themselves were not significantly different between the two groups. The non-amputated limbs had significantly smaller peak hip flexion moment and peak knee extension moment, with significant differences between the muscle forces of non-amputated limbs and controls at the two instants. There was no significant difference between the muscle forces of the non-amputated limbs and controls at the peak knee flexion moment instant, despite the fact that the non-amputated limbs had significantly higher peak knee flexion moments. In addition, the non-amputated limbs had significantly smaller maximum muscle forces than the controls. These results demonstrate that amputees modify their muscle coordination to adapt to the specific joint requirements of the prosthetic gait. Our findings suggest the possibility of non-amputated limb muscle atrophy due to the decrease in the peak muscle forces during walking.
Mechanisms used to increase propulsive forces on a treadmill in older adults.
Venue: Journal of biomechanics

Older adults typically demonstrate reductions in overground walking speeds and propulsive forces compared to young adults. These reductions in walking speeds are risk factors for negative health outcomes. Therefore, this study aimed to determine the effect of an adaptive speed treadmill controller on walking speed and propulsive forces in older adults, including the mechanisms and strategies underlying any change in propulsive force between conditions. Seventeen participants completed two treadmill conditions, one with a fixed comfortable walking speed and one with an adaptive speed controller. The adaptive speed treadmill controller utilized a set of inertial-force, gait parameters, and position-based controllers that respond to an instantaneous anterior inertial force. A biomechanical-based model previously developed for individuals post-stroke was implemented for older adults to determine the primary gait parameters that contributed to the change in propulsive forces when increasing speed. Participants walked at faster average speeds during the adaptive speed controller (1.20 m/s) compared to the fixed speed controller conditions (0.98 m/s); however, these speeds were not as fast as their overground speed (1.44 m/s). Although average trailing limb angle (TLA) (p < 0.001) and ankle moment (p = 0.020) increased when speed also increased between treadmill conditions, increasing TLA contributed more to the increased propulsive forces seen during faster treadmill speeds. Our findings show that older adults chose faster walking speeds and increased propulsive force when walking on an adaptive speed treadmill compared to a fixed speed treadmill, suggesting that an adaptive speed treadmill controller has the potential to be a beneficial alternative to current exercise interventions for older adults.
An individualized linear model approach for estimating scapular kinematics during baseball pitching.
Venue: Journal of biomechanics

Assessment of scapulothoracic and glenohumeral contributions to shoulder function during baseball pitching are limited by challenges in accurately measuring dynamic scapular orientation. A recently validated individualized linear model approach that estimates scapular orientation based on measurable humerothoracic orientation has yet to be adapted for pitching and may improve upon currently recommended methods such as the acromion marker cluster (AMC). This study evaluates the ability of a pitching-specific individualized linear model to estimate scapular orientation in static positions throughout a throwing motion by comparing against palpation and an AMC. Individualized linear models were created for 14 collegiate pitchers by determining scapulothoracic and humerothoracic orientations at static arm postures throughout their individual dynamic throwing motions. Linear model and AMC estimates were compared against palpation at intermediate test positions within the throwing motion that were excluded from model creation. Linear model estimates were similar to palpation at all test positions and on all scapulothoracic axes while AMC estimates differed on internal/external rotation and anterior/posterior tilt during cocking (p = 0.001, p = 0.018) and follow-through (p = 0.003, p = 0.006). Linear model root mean square error (RMSE) values were smaller than AMC values for all positions/axes. Linear model RMSE values (2.8-6.3°) were within a range of published values previously deemed acceptable, while AMC values (5.1-15.8°) went beyond this range. The linear model approach accurately estimates static scapular orientation throughout a pitching motion and improves upon current methods. Future applications to dynamic pitching may facilitate understanding of how scapulothoracic and glenohumeral joint function relate to injury risks, rehabilitation, and performance.
Untangling biomechanical differences in perturbation-induced stepping strategies for lateral balance stability in older individuals.
Venue: Journal of biomechanics

When recovering balance from a lateral perturbation, younger adults tend to stabilize balance with a single lateral sidestep while older adults often take multistep responses. Using multiple steps to recover balance is consistently associated with increased fall risk, altered body center of mass (CoM) control and instability. The aim of this study was to compare the spatio-temporal stepping characteristics and the margin of stability (MoS) of single lateral sidesteps (LSS1) with the first and second steps of a two-step protective step sequence. Two-step sequences begin with either a cross-over step to the front or back, or a medial step followed by a lateral sidestep. Seventy-one older adults received random lateral waist-pull perturbations to either side. We hypothesized that LSS1 would be more stable (larger MoS) than either step in a two-step sequence. With some exceptions, utilizing a two-step sequence was associated with a reduced CoM velocity and distance between the base of support and CoM and decreased stability in the frontal plane following limb loading of the first and second step. There were no differences in the time available to arrest the extrapolated CoM at the end of a single lateral sidestep or the final step of a two-step sequence. Two-step sequences involving a cross-over step include more complex stepping trajectories and also challeng stability in the sagittal plane requiring a multidimensional balance correction. These results indicate important step type differences in center of mass control in recovering balance with a single lateral sidestep as opposed to a two-step sequence among older adults.