nils-herrmann/clean_scirepeval huggingface dataset:
Accuracy of the tibiofemoral contact forces estimated by a subject-specific musculoskeletal model with fluoroscopy-based contact point trajectories.
Venue: Journal of biomechanics

Accurate estimation of the tibiofemoral contact forces relies on exact kinematics and joint geometry. Subject-specific kinematic constraints representing contact point trajectories derived from fluoroscopic measurements during lunge are introduced in a musculoskeletal model of the lower limb and compared to generic kinematic constraints. The medial, lateral, and total contact forces during gait and squat are validated using the data of four patients with an instrumented prosthesis. The accuracy of the estimated contact forces (both with subject-specific and generic kinematic constraints) remains close to the level reported in the literature. The mean root mean square errors range from 0.32 to 0.52 body weights for gait and from 0.27 to 0.72 body weights for squat. The impact of the subject-specific contact point trajectories is not found substantial or consistent between patients and tasks. Indeed, the kinematics of the total knee prostheses remains close to the kinematics of a hinge joint and the contact point locations remain generally centred at 20 mm from the tibia centreline (close to the constant value defined in the generic constraints). The contact point trajectories are also suspected to differ between tasks (lunge vs. gait and squat). While the contact point trajectories have been reported to be sensitive model parameters, no clear improvement of the contact force accuracy is demonstrated on patients with instrumented prosthesis. The introduction (as kinematic constraints) of fluoroscopy-based contact point trajectories may be considered in cases where these trajectories are significantly altered, as reported for osteoarthritis patients.
A comparison of attachment methods of skin mounted inertial measurement units on tibial accelerations.
Venue: Journal of biomechanics

Peak tibial accelerations during running are of interest because of their correlation with vertical ground reaction force load rates and association with running injury. Previous work has demonstrated systematically lower accelerations measured with a bone- compared to skin-mounted accelerometer. However, no studies have assessed the effects of more or less secure attachment methods for skin mounted sensors. Our purpose was to compare two methods of attaching a skin mounted sensor on mean tibial accelerations, stride-to-stride variability, and correlations with vertical load rates. 18 injury-free runners were recruited as participants. An inertial measurement unit, containing a tri-axial accelerometer, was used to record tibial accelerations while participants ran at a self-selected speed on an instrumented treadmill to collect ground reaction forces. The two attachment methods for securing the sensor to the skin were a manufacturer-provided strap (strap condition) and a combination of tape and elastic wraps (wrap condition). Mean vertical accelerations were significantly lower in the wrap condition (p = 0.02, d = 0.57). No differences were detected in resultant accelerations, vertical loading rates, or stride-to-stride variability. Correlations between tibial accelerations and vertical loading rates were strong (r = 0.79-0.91) and similar between conditions. These results provide two key findings of evidence. Evidenced by systematically lower vertical accelerations, a more secure attachment method may be necessary for capturing the most representative measure of tibial accelerations during running. However, a less secure method (i.e. the strap) is sufficient for capturing tibial accelerations as a surrogate for impact loading forces.
Three-dimensional measurement of proximal radioulnar space during active forearm pronation.
Venue: Journal of biomechanics

Distal biceps tendon ruptures have been reported to be associated with narrowing of the proximal radioulnar space. There have been no studies that three-dimensionally measured the distance between the bicipital tuberosity and the proximal ulna during active motion. The purpose of this study was to three-dimensionally measure the proximal radioulnar space during active forearm pronation in healthy subjects. Five healthy volunteers (10 forearms) were recruited for this study. They consisted of all males with a mean age of 37 years (range, 34-46 years). Lateral fluoroscopy of forearm rotation from maximum supination to maximum pronation was recorded for both forearms. Three-dimensional forearm kinematics were determined using model-image registration techniques with fluoroscopic images and CT-derived bone models, and the closest distance between the bicipital tuberosity and the proximal ulna was computed at each 30° increment of radial axial rotation relative to the distal humerus. The distance between the bicipital tuberosity and the proximal ulna decreased with pronation, reaching a minimum value at 90° of radial rotation (average 4.6 ± 1.3 mm), then increased with further rotation to maximum pronation (P = 0.004). The clearance between the proximal radioulnar space and the distal biceps tendon is very small (<1mm). Hypertrophy of the bicipital tuberosity or tendon can induce impingement and lead to tendon rupture.
Sex-specific landing biomechanics and energy absorption during unanticipated single-leg drop-jumps in adolescents: implications for knee injury mechanics.
Venue: Journal of biomechanics

Females aged between 13 and 17 years old possess the highest non-contact ACL injury incidence of any sex-age strata. Considering that energy absorption strategies have been associated with a reduced risk for sustaining an ACL injury, evaluating landing performance in youth athletes requires investigations beyond the kinematic level. The purpose of this study was to identify sex-specific energy absorption strategies in adolescent males and females, including the relationship between strength and the observed strategies. Thirty-one healthy adolescent athletes completed unanticipated single-leg drop-jump landings on their dominant limb. Sex-specific kinematics and lower-limb contributions to energy absorption were then compared over the landing phase for each jump. Pearson and Spearman correlation coefficients determined the relationship between isometric joint strength and the observed kinematics and energy absorption. Female participants absorbed a larger proportion of the landing energy at the ankle (p = 0.046, d = 0.75) and smaller proportion at the hip (p = 0.028, d = 0.85) compared to males. Females also reached larger peak negative joint power in their knee (p = 0.001, d = 1.1) and ankle (p = 0.04, d = 0.79). Hip extension strength was positively correlated with trunk flexion (r = 0.559, p = 0.001) and negatively correlated with forward pelvic tilt (r = -0.513, p = 0.003). Females adopted an energy absorption strategy which utilized the distal joints to absorb a larger portion of the landing forces and tended to absorb the forces later in the landing phase relative to males. The greater reliance on distal joints is correlated to reduced hip strength and may increase the risk for sustaining an ACL injury.
Improvement in trunk kinematics after treadmill-based reactive balance training among older adults is strongly associated with trunk kinematics before training.
Venue: Journal of biomechanics

Reactive balance training (RBT) is an emerging fall prevention exercise intervention for older adults. To better understand factors that influence improvements after RBT, the goal of this study was to identify key factors that strongly associate with training-induced improvements in reactive balance. This study is a secondary analysis of data from a prior study. Twenty-eight residents of senior housing facilities participated, including 14 RBT participants and 14 Tai Chi participants (controls). Before and one week after training, participants completed balance and mobility tests and a reactive balance test. Reactive balance was operationalized as the maximum trunk angle in response to standardized trip-like perturbations on a treadmill. Bivariate (Pearson) correlation was used to identify participant characteristics before RBT and measures of performance during RBT that associated with training-induced changes in maximum trunk angle. Maximum trunk angle before reactive balance training exhibited the strongest association with training-induced changes in maximum trunk angle among RBT participants (r2 = 0.84; p < .001), but not among Tai Chi participants (r2 = 0.17; p = .138). Measures of performance during RBT, based upon perturbation speed, also associated with RBT-induced improvements in maximum trunk angle. These results help clarify the characteristics of individuals who can benefit from RBT, and support the use of treadmill perturbation speed as a surrogate measure of training-induced improvements in trunk kinematics.
Negotiating ground level perturbations in walking: Visual perception and expectation of curb height modulate muscle activity.
Venue: Journal of biomechanics

To negotiate visible and unpredictable changes in ground level, humans use different control strategies depending on the visibility. In case of fully visible perturbations, humans can anticipate the occurrence and the magnitude of the perturbation. In case of a camouflaged perturbation, they can anticipate the occurrence based on the camouflage cover but need to predict the magnitude from experience, as it is not visible. The purpose of this study was to investigate the anticipatory muscular control strategy humans employ when walking down curbs of different height and to investigate how this strategy differs if the step down is fully visible or camouflaged. The activity of five bilateral lower limb muscles (M. gastrocnemius medialis, M. soleus, M. tibialis anterior, M. biceps femoris and M. vastus medialis) of eight healthy subjects was recorded during walking down visible (0, -10 and -20 cm) and camouflaged curbs (0 and -10 cm). The results reveal that the M. gastrocnemius shows a clear anticipatory adaptation to visible curbs in the contralateral and partly also the ipsilateral leg, which further depends on the curb height. Furthermore, in case of a camouflaged perturbation, M. gastrocnemius activity of the contralateral leg shows an adaptation that indicates an average prediction of the curb height, presumably based on previous experience.
Ground reaction force profiles during inclined running at iso-efficiency speeds.
Venue: Journal of biomechanics

While running provides an accessible form of cardiovascular stimulus, many runners report lower extremity musculoskeletal injuries. Additionally, runners who develop overuse injuries, such as tibial stress fractures, also have higher loading rates (LR) and impact forces.



Therefore, the purpose of this study was to investigate how uphill treadmill running at iso-efficient speeds (IES; a speed-incline combination having the same metabolic intensity as level running) influences impact LR, and peak vertical ground reaction forces (GRF).



Eleven collegiate distance runners completed 3 experimental running conditions (0%, 4%, and 8% treadmill inclination). During each running condition, the metabolic intensity was controlled by implementing an IES for each runner.



All variables of interest were significantly reduced as treadmill incline increased (0% > 4% > 8%).



Incline running is more metabolically demanding compared to level running at the same speed. But, if speed is controlled to maintain metabolic output, runners could decrease LR and peak vertical GRF while achieving the same metabolic training stimulus as level running.
Low-cycle full-field residual strains in cortical bone and their influence on tissue fracture evaluated via in situ stepwise and continuous X-ray computed tomography.
Venue: Journal of biomechanics

As a composite material, the mechanical properties of bone are highly dependent on its hierarchical organisation, thus, macroscopic mechanical properties are dictated by local phenomena, such as microdamage resulting from repetitive cyclic loading of daily activities. Such microdamage is associated with plastic deformation and appears as a gradual accumulation of residual strains. The aim of this study is to investigate local residual strains in cortical bone tissue following compressive cyclic loading, using in situ X-ray computed tomography (XCT) and digital volume correlation (DVC) to provide a deeper insight on the three-dimensional (3D) relationship between residual strain accumulation, cortical bone microstructure and failure patterns. Through a progressive in situ XCT loading-unloading scheme, localisation of local residual strains was observed in highly compressed regions. In addition, a multi-scale in situ XCT cyclic test highlighted the differences on residual strain distribution at the microscale and tissue level, where high strains were observed in regions with the thinnest vascular canals and predicted the failure location following overloading. Finally, through a continuous in situ XCT compression test of cycled specimens, the full-field strain evolution and failure pattern indicated the reduced ability of bone to plastically deform after damage accumulation due to high number of cyclic loads. Altogether, the novel experimental methods employed in this study, combining high-resolution in situ XCT mechanics and DVC, showed a great potential to investigate 3D full-field residual strain development under repetitive loading and its complex interaction with bone microstructure, microdamage and fracture.
Effects of different positions of intravascular stent implantation in stenosed vessels on in-stent restenosis: An experimental and numerical simulation study.
Venue: Journal of biomechanics

Percutaneous coronary intervention (PCI) has been widely used in the treatment of atherosclerosis, while in-stent restenosis (ISR) has not been completely resolved. Studies have shown that changes in intravascular mechanical environment are related to ISR. Hence, an in-depth understanding of the effects of stent intervention on vascular mechanics is important for clinically optimizing stent implantation and relieving ISR. Nine rabbits with stenotic carotid artery were collected by balloon injury. Intravascular stents were implanted into different longitudinal positions (proximal, middle and distal relative to the stenotic area) of the stenotic vessels for numerical simulations. Optical coherence tomography (OCT) scanning was performed to reconstruct the three-dimensional configuration of the stented carotid artery and blood flow velocity waveforms were collected by Doppler ultrasound. The numerical simulations were performed through direct solution of Naiver-Stokes equation in ANSYS. Results showed that the distributions of time-averaged wall shear stress (TAWSS), oscillating shear index (OSI) and relative residual time (RRT) in near-end segment were distinctively different from other regions of the stent which considered to promote restenosis for all three models. Spearman rank-correlation analysis showed a significant correlation between hemodynamic descriptors and the stent longitudinal positions (rTAWSS = -0.718, rOSI = 0.898, rRRT = 0.818, p < 0.01). Histology results of the near-end segment showed neointima thickening deepened with the longitudinal positions of stent which was consistent with the numerical simulations. The results suggest that stent implantation can promote restenosis at the near-end segment. As the stenting position moves to distal end, the impact on ISR is more significant.
Estimation of the ground reaction forces from a single video camera based on the spring-like center of mass dynamics of human walking.
Venue: Journal of biomechanics

In clinical studies, the ground reaction forces (GRFs) during walking have found being highly useful. Therefore, the force sensing shoes with small sensors and estimation methods based on kinematics from motion capture systems or inertial measurement units were proposed. Recent studies demonstrated methods of extracting GRFs from whole-body joint kinematics, which requires a significant computational load. In this study, we propose a vertical and anterior-posterior GRFs estimation method using a single camera based on the dynamic relationship between the center of mass (CoM) and the GRFs in terms of spring mechanics. The estimation method consisted of two steps: the extraction of the vertical CoM from the video clip and the conversion of the CoM information into GRFs using a walking model. From the image of the greater trochanter that is positioned near the pelvic joint, the vertical CoM was extracted. This was done after removing the artifacts by pelvic rotation and postural change of lower limbs. The parameters of a compliant bipedal walking model were tuned to best match the CoM trajectory coupled with GRFs by spring mechanics. A video camera was used to record the walking trials of five healthy young participants from the side. The walking trials was conducted at three different speeds on the instrumented treadmill; each lasted one minute long. The GRF prediction errors were approximately 9-11%, with the best matching trials found to be at a self-selected gait speed. The prediction of anterior-posterior GRF components showed a more consistent match than the vertical GRF. The results demonstrated the possibility of marker-less kinetics prediction from video images incorporating the mechanical characteristics of the CoM.
Micromechanical poroelastic and viscoelastic properties of ex-vivo soft tissues.
Venue: Journal of biomechanics

Soft biological tissues demonstrate strong time-dependent mechanical behavior, arising from their intrinsic viscoelasticity and fluid flow-induced poroelasticity. It is increasingly recognized that time-dependent mechanical properties of soft tissues influence their physiological functions and are linked to several pathological processes. Nevertheless, soft tissue time-dependent characteristics, especially their micromechanical variation with tissue composition and location, remain poorly understood. Nanoindentation is a well-established technique to measure local elastic properties but has not been fully explored to determine micro-scale time-dependent properties of soft tissues. Here, a nanoindentation-based experimental strategy is implemented to characterize the micro-scale poroelastic and viscoelastic behavior of mouse heart, kidney, and liver tissues. It is demonstrated that heart tissue exhibits substantial mechanical heterogeneity where the elastic modulus varies spatially from 1 to 30 kPa. In contrast, both kidney and liver tissues show relatively homogeneous response with elastic modulus 0.5-3 kPa. All three tissues demonstrate marked load relaxation under constant indentation, where the relaxation behavior is observed to be largely dominated by tissue viscoelasticity. Intrinsic permeability varies among different tissues, where heart tissue is found to be less permeable compared to kidney and liver tissues. Overall, the results presented herein provide key insights into the time-dependent micromechanical behavior of different tissues and can therefore contribute to studies of tissue pathology and tissue engineering applications.
Full-field comparisons between strains predicted by QCT-derived finite element models of the scapula and experimental strains measured by digital volume correlation.
Venue: Journal of biomechanics

Subject-specific finite element models (FEMs) of the shoulder can be used to evaluate joint replacement designs preclinically. However, to ensure accurate conclusions are drawn, experimental validation is critical. The objective of the current study was to evaluate the accuracy of strain predictions generated by subject-specific scapula FEMs through comparisons against full-field experimental strains measured using digital volume correlation (DVC). Three cadaveric scapulae were mechanically loaded using a custom-hexapod robot within a micro-CT scanner. BoneDVC was used to quantify resultant experimental full-field strains. Scapula FEMs were generated using three different density-modulus relationships to assign material properties. Two types of boundary conditions (BCs) were simulated: DVC-displacement-driven or applied-force-driven. Third principal strains were compared between the DVC measurements and FEM predictions. With applied-force BCs, poor agreement was observed between the predicted and measured strains (slope range: 0.16-0.19, r2 range: 0.04-0.30). Agreement was improved with the use of DVC-displacement BCs (slope range: 0.54-0.59, r2 range: 0.73-0.75). Strain predictions were independent of the density-modulus relationship used for DVC-displacement BCs, but differences were observed in the correlation coefficient and intercept for applied-force BCs. Overall, this study utilized full-field DVC-derived experimental strains for comparison with FEM predicted strains in models with varying material properties and BCs. It was found that fair agreement can be achieved in localized strain measurements between DVC measurements and FEM predictions when DVC-displacement BCs are used. However, performance suffered with use of applied-force BCs.
Comparison of the effects of chair height and anterior seat inclination on sit-to-stand ability in children with spastic diplegic cerebral palsy.
Venue: Journal of biomechanics

The present study aimed to compare the effects of chair height and anterior seat inclination on sit-to-stand (STS) performance in children with spastic diplegic cerebral palsy (SDCP). Twelve children with SDCP were tested with three conditions of STS task: low chair with horizontal seat (control), low chair with anterior seat inclination (AiC), and high chair with horizontal seat (HiC) conditions. A 3D motion analysis system and two force plates were used to collect and analyze the movement time, mechanical work, kinematics, and kinetics. The results showed that in the AiC and HiC conditions, movement time and mechanical work during STS were significantly reduced when compared with the control condition. In addition, in the AiC condition, trunk alignment at the beginning of the STS task improved and the range of pelvis movement reduced, whereas in the HiC condition, the range of movement of hip, knee, and ankle joint and maximum hip and knee extension moment were reduced in children with SDCP when compared with the control condition. These results suggest that chair height and anterior seat inclination may have a positive effect on STS ability in children with SDCP.
The effect of text-based math task on dynamic stability control during stair descent (ID: BM-D-20-00079R3).
Venue: Journal of biomechanics

Stair descent imposes a significant challenge for dynamic stability among young adults. The effect of a concurrent text-based math task on dynamic stability control remains unclear during stair descent when considering the influence of gait velocity. Twenty-six participants performed three successful stair descent trials under TEXTING or NO-TEXTING conditions at their preferred speed. Synchronous kinematics and kinetics were collected by an eight-camera Vicon infrared motion capture system and two force platforms. Repeated measures analysis of covariance and Wilcoxon signed rank test were used to analyze the differences between the two different task conditions with gait velocity as a covariate. The outcomes indicated that under TEXTING condition, sagittal margin of stability increased at right-foot-landing; step cadence, double-support percentage, sagittal and frontal joint moment decreased; and sagittal and frontal joint angles were also modified. It is concluded that concurrent TEXTING impaired sagittal and frontal stability control during stair descent despite slowing down the step cadence. Knee and ankle joint adjustment strategies were mainly adopted in response to stability control in the sagittal plane with the interference of TEXTING, whereas the hip joint adjustment strategy was adopted in the frontal plane. In conclusion, texting behaviors on mobile phones should be minimized during stair descent.