nils-herrmann/clean_scirepeval huggingface dataset:
Assessment of trunk muscle activation and intervertebral load in adolescent idiopathic scoliosis by musculoskeletal modelling approach.
Venue: Journal of biomechanics

Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine, the aetiology and pathogenesis of which are poorly understood. Unfortunately, biomechanical data describing trunk muscle activation and intervertebral load, which can contribute to understanding the pathomechanics of the AIS spine, cannot be measured in vivo due to the invasiveness of the procedures. The present study provides the biomechanical characterization of the spinal loads in scoliotic subjects by exploiting musculoskeletal modelling approach, allowing for calculating biomechanical measures in an assigned posture. A spine model with articulated ribcage previously developed in AnyBody software was applied. The predicted outcomes were evaluated in the upright posture, depending on scoliosis severity and curve type, in a population of 132 scoliotic subjects with mild, moderate, and severe scoliosis. Radiographic-based three dimensional reconstruction of vertebral orientations and scaling of body segments and trunk muscle cross-section area guaranteed geometrical subject-specificity. Validation analysis supporting the application of the model was performed. Trunk muscles were found more activated in the convex side of the scoliotic curve, in agreement with reference in vivo measurements, with progressive increase with scoliosis severity. The intervertebral lateral shear was found positively correlated with the severity of the scoliosis, demonstrating that the transferred load is not a priori orthogonal to vertebral endplate in the frontal plane, and thus questioning the assumption of the 'follower load' approach in case of experimental or computational study on the scoliotic spine. The study opens the way for the subject-specific characterization of scoliosis in assigned loading and motion conditions.
Rate of torque development scaled to maximum torque available is velocity dependent.
Venue: Journal of biomechanics

The influence of angular velocity on rate of torque development (RTD) is unknown, despite the inverse, curvilinear torque-velocity relationship for angle- and velocity-specific maximum available torque (Tmax) being well-established. This study investigated the relationship between angular velocity and RTD scaled to Tmax. In 17 participants, tetanic contractions (100-Hz) of the knee extensors were evoked as the knee was passively extended at different iso-velocities between 0° s-1 and 200° s-1. Each condition consisted of evoking 0.25-s contractions without pre-activation (for measuring RTD) commencing as the knee passed 95° of extension, and 1.25-s contractions with pre-activation (for measuring Tmax), commencing 1 s prior to the knee reaching 95°. Torque at 100 ms after torque onset (T100) and peak RTD (RTDpeak) in the contractions without pre-activation were normalised to Tmax. The torque-velocity relationship for T100 was flat in comparison to an inverse, curvilinear relationship for Tmax, resulting in linear increases in normalised T100 and RTDpeak with increased velocity. Results also showed normalised T100 and RTDpeak were likely overestimated due to shortening-induced force depression (FD) which would be greater in contractions with- than without- pre-activation. However, these effects of FD cannot explain the faster normalised RTD with increased velocity, as the relative difference in work done (a proxy for FD) between contractions with and without pre-activation decreased - and thus the overestimation of normalised RTD metrics likely decreased - with increased velocity. In conclusion, RTD scaled to Tmax increases with increased velocity, which appears to be an intrinsic contractile property independent of the effects of force depression.
In-vivo tongue stiffness measured by aspiration: Resting vs general anesthesia.
Venue: Journal of biomechanics

Tongue cancer treatment often results in impaired speech, swallowing, or mastication. Simulating the effect of treatments can help the patient and the treating physician to understand the effects and impact of the intervention. To simulate deformations of the tongue, identifying accurate mechanical properties of tissue is essential. However, not many succeeded in characterizing in-vivo tongue stiffness. Those who did, measured the tongue At Rest (AR), in which muscle tone subsides even if muscles are not willingly activated. We expected to find an absolute rest state in participants 'under General Anesthesia' (GA). We elaborated on previous work by measuring the mechanical behavior of the in-vivo tongue under aspiration using an improved volume-based method. Using this technique, 5 to 7 measurements were performed on 10 participants both AR and under GA. The obtained Pressure-Shape curves were first analyzed using the initial slope and its variations. Hereafter, an inverse Finite Element Analysis (FEA) was applied to identify the mechanical parameters using the Yeoh, Gent, and Ogden hyperelastic models. The measurements AR provided a mean Young's Modulus of 1638 Pa (min 1035 - max 2019) using the Yeoh constitutive model, which is in line with previous ex-vivo measurements. However, while hoping to find a rest state under GA, the tongue unexpectedly appeared to be approximately 2 to 2.5 times stiffer under GA than AR. Explanations for this were sought by examining drugs administered during GA, blood flow, perfusion, and upper airway reflexes, but neither of these explanations could be confirmed.
Comparison of methods of derivation of the yank-time signal from the vertical ground reaction force-time signal for identification of movement-related events.
Venue: Journal of biomechanics

Temporal changes in ground reaction force magnitudes reflect movement strategy, and thus underlying muscle activation patterns, during movement tasks. Speculatively, these changes may be observed more readily when the force-time signal is differentiated, yielding the yank-time signal. However, the differentiation process, including the signal filtering used before or after differentiation, can significantly affect the signal-to-noise ratio (SNR) and likelihood of meaningful inference. The aim of the present study was to compare three methods of deriving the yank-time signal: Method 1 derived the yank-time signal using 2nd-order central differentiation subsequent to application of a 4th-order Butterworth filter; Method 2 included the same process as Method 1 but additionally filtered the yank-time data with a Savitzky-Golay smoothing filter; and Method 3 directly and simultaneously derived and smoothed the yank-time signal using a Savitzky-Golay digital differentiation filter. The current analyses revealed Method 2 had the best SNR, followed by Methods 3 and 1, but caused a small loss of signal amplitude. With regards to timing of inflection points in the yank-time data, no significant difference was observed. Therefore, Method 3 led to the best derivation of the yank-time signal due to its efficiency and preservation of signal characteristics and good SNR. Also, a strong association between the first maximum point of the yank-time signal and the start of the downward movement of the body's centre of mass during a countermovement jump, as identified by 3-D motion analysis, was observed. Thus, subtle events (e.g. start of downward movement) can be easily observed in the yank-time signal.
The sagittal sways of back lordosis and sacral orientation during still standing at different arm positions.
Venue: Journal of biomechanics

Lumbo-pelvic parameters in the sagittal plane are normally measured from lateral radiographs obtained at a single time point during upright standing with arms held forward to expose anatomical bony structures. However, the human trunk naturally sways during still standing, which potentially alters the targeted parameters. We therefore aimed to investigate the effect of postural sway on lumbo-pelvic parameters during still standing at different arm positions. A non-radiological back measurement device was used to determine the absolute changes of back lordosis and sacral orientation during one-minute still standing while participants (10 males and 10 females without low back pain) held their arms at eight different positions. When the arms were freely hanging down at both sides, males displayed median values of 25.2° (range: 15.6-45.0°) and 7.4° (range: 2.0-26.7°) for back lordosis and sacral orientation, which were smaller than those of 33.1° (range: 11.9-41.9°) and 16.1° (range: 0.8-22.8°) for females, respectively (P < 0.05). At the same arm position, the median values were 2.7° (range: 1.3-5.2°) and 2.9° (range: 1.6-4.5°) for change of back lordosis and change of sacral orientation, respectively. Sex displayed no significant influence for both measures. Different arm positions non-significantly affected the change of back lordosis. When hands rested on horizontal bars, the change of sacral orientation was significantly less than during other arm positions (P < 0.05). Hence, back lordosis and sacral orientation inherently change during still standing, independently of sex and arm position, which could compromise the reliability of measurements at a single time point. When categorizing subjects into groups with normal or abnormal lumbo-pelvic balance, this variability should be taken into consideration.
Reliability and quality of statistical shape and deformation models constructed from optical foot scans.
Venue: Journal of biomechanics

The unique shape of modern human feet, and how they change shape when loaded are thought to be integral to effective upright gait. This unique shape, and the natural variations therein, have previously been analysed using a range of methods; from visual assessments, anthropometric measurements, and footprints, to x-ray, ultrasound and magnetic resonance images. However, these methods are often limited by their use of linear two-dimensional measures. Only recently have advances in three-dimensional (3D) scanning technology and statistical shape analysis been applied to studying 3D foot shape variations. Given their novelty, information regarding the reliability and repeatability of 3D foot scanning and shape modelling is lacking. To investigate whether repeated foot scans captured by two examiners give the same 3D shape and produce consistent statistical shape models, 17 healthy adults' left feet were scanned while bearing half and full bodyweight, as well as minimal weight. Surface to surface distances between corresponding foot meshes and differences between shape model quality criteria were both found to be small and insignificant. The only exception being the specificity criterion for minimally loaded foot scans. Furthermore, Euclidean vectors were used to model the magnitude and direction of deformation that feet undergo as a consequence of increased loading. The deformation models showed that loading a minimally loaded foot results in greater, but less consistent, shape changes than when increasing the load on an already loaded foot. These results show that the utilized methods offer a valuable, reliable and repeatable approach to analysing foot shape and deformation.
Biomechanical evaluation of the docking nail concept in periprosthetic fracture fixation around a stemmed total knee arthroplasty.
Venue: Journal of biomechanics

Intramedullary femoral nails provide an ideal mechanical axis for periprosthetic fracture fixation. Slotted nails allow a connection to a total knee arthroplasty (TKA) stem. This study aims to compare implant and construct stiffness, interfragmentary movement and cycles to failure between an antegrade slotted femoral nail construct docked to a TKA stem and a distal femoral locking plate in a human periprosthetic femoral fracture model. In eight pairs of fresh-frozen human femora with stalked TKA, a 10 mm transverse osteotomy gap was set simulating a Rorabeck type II, Su type I fracture. The femora were pairwise instrumented with either an antegrade slotted nail coupled to the prosthesis stem, or a locking plate. Cyclic testing with a progressively increasing physiologic loading profile was performed at 2 Hz until catastrophic construct failure. Relative movement at the osteotomy site was monitored by means of optical motion tracking. In addition, four-point bending implant stiffness, torsional implant stiffness and frictional fit of the stem-nail connection were investigated via separate non-destructive tests. Intramedullary nails exhibited significantly higher four-point bending and significantly lower torsional implant stiffness than plates, P < 0.01. Increasing difference between nail and stem diameters decreased frictional fit at the stem-nail junction. Nail constructs provided significantly higher initial axial bending stiffness and cycles to failure (200 ± 83 N/mm; 16'871 ± 5'227) compared to plate constructs (93 ± 35 N/mm; 7'562 ± 1'064), P = 0.01. Relative axial translation at osteotomy level after 2'500 cycles was significantly smaller for nail fixation (0.14 ± 0.11 mm) compared with plate fixation (0.99 ± 0.20 mm), P < 0.01. From a biomechanical perspective, the docking nail concept offers higher initial and secondary stability under dynamic axial loading versus plating in TKA periprosthetic fracture fixation.
Microdamage formation in individual bovine trabeculae during fatigue testing.
Venue: Journal of biomechanics

Ageing, disease and osteoporosis treatment have been linked to accumulation of microdamage, which is caused by repetitive loading and may eventually causes fatigue failure of bones. Post-hoc investigations for in vivo loading and in vitro experiments have been developed to better understand microdamage formation. In this context, previous studies were not able to discriminate the effects caused by structural changes of the trabecular network from differences of tissue/material properties on microdamage formation. In the present study a fatigue test protocol was established to induce microdamage at a defined tensile stress state of individual trabeculae. Further, a thorough analysis of microdamage analysis was presented for 2D and 3D confocal images, enabling a comparison between the tissue and the meso-scale. Eight individual trabeculae were tested for 1500 cycles, six for 2100 cycles and seven for 3000 cycles (close to failure). Microdamage increased slowly from 1500 to 2100 cycles and showed a rapid increase at 3000 cycles. Diffuse damage was mainly present, although also linear microcracks were visible at 2100 and 3000 cycles. Average microcrack length was 93 µm and diffuse damage density was 4.4% for samples tested for 3000 cycles, comparable to previous studies on trabecular bone cores. Only one to three large microdamage sites were observed in the central region, connected to the trabecular surface with small straight cracks. The presented procedure is a first step to better understand how microdamage formation is influenced by material properties in aged and diseased bone, independently of deteriorated trabecular microarchitecture.
Effects of paclitaxel on the viscoelastic properties of mouse sensory nerves.
Venue: Journal of biomechanics

Paclitaxel is an effective and widely used chemotherapeutic, but also causes debilitating peripheral sensory neuropathy. Due to its influence on microtubule stability, we and others have hypothesized that paclitaxel alters neuromechanical properties. A prior study suggested that paclitaxel increases the tensile moduli of rat sensory nerves. However, the effects of paclitaxel on tissue level viscoelasticity have not been tested. In this study, sural branches of C57BL/6J mouse sciatic nerves were bilaterally excised. One nerve was treated with Ringer's solution containing paclitaxel, and the contralateral nerve with Ringer's alone. Nerves were then subject to a passive loading protocol in which peak stress, relaxed stress, and stress-relaxation dynamics were monitored at increasing strain. Elastic and tangent tensile moduli were calculated from both peak and relaxed stress-strain curves as well as failure stress were significantly elevated in paclitaxel-treated nerves compared to controls. Double-exponential fits (with τm and τn indicating fast and slow time constants, respectively) were successfully applied to model stress-relaxation. Though no significant differences in the τm and τn were found between groups, paclitaxel treatment significantly increased the variability of τm, suggesting heterogeneous effects on nerve biomechanical properties. Our data establish that paclitaxel effects at the cellular level influence tensile viscoelastic properties of nerves at the tissue level. These results have implications for understanding biomechanical influences on the progression and physical rehabilitation of paclitaxel-induced neuropathy.
Continuous estimation of ground reaction force during long distance running within a fatigue monitoring framework: A Kalman filter-based model-data fusion approach.
Venue: Journal of biomechanics

Estimation of ground reaction forces in runners has been limited to laboratory environments by means of instrumented treadmills, in-ground force plates and optoelectronic systems. Recent advances in estimation techniques using wearable sensors for kinematic analysis and sports performance could enable estimation outside the laboratory. This paper proposes a state-input-parameter estimation framework to continuously estimate the vertical ground reaction force waveform during running. By modeling a runner as a single degree of freedom mass-spring-damper with acceleration measurements at the sacrum a state-space formulation can be applied using Newtonian methods. A dual-Kalman filter is employed to estimate the unmeasured system input which feeds through to an unscented Kalman filter to estimate system dynamics and unknown model parameters (e.g. spring stiffness). For validation, 14 subjects performed three one-minute running trials at three different speeds (self-selected slow, comfortable, and fast) on a pressure-sensor-instrumented treadmill. The estimated vertical ground reaction force waveform parameters; peak vertical ground reaction force (RMSE=6.1-7.2%,ρ=0.95-0.97), vertical impulse (RMSE=8.5-13.0%,ρ=0.50-0.60), loading rate (RMSE=24.6-39.4%,ρ=0.85-0.93), and cadence RMSE<1%,ρ=1.00 were compared against the instrumented treadmill measurements. The proposed state-input-parameter estimation framework could monitor personalized vertical ground reaction force metrics for potential biofeedback applications. The feedback mechanism could provide information about the vertical ground reaction force characteristics to the runner as they are running to provide knowledge of both desirable and undesirable loading characteristics experienced.
Influence of the posterior cruciate ligament on kinematics of the knee during experimentally simulated clinical tests and activities of daily living.
Venue: Journal of biomechanics

Clinical outcomes following posterior cruciate ligament (PCL) reconstruction are often suboptimal. A better understanding of the biomechanical contributions of the PCL to knee stability under physiologic, clinically-relevant loading conditions could improve reconstruction techniques and outcomes. We employed a servohydraulic joint motion simulator to investigate the kinematics of intact and PCL-deficient knees during simulated clinical tests and activities of daily living(ADL), including gait, stair ascent and descent. PCL transection caused the tibia to be displaced posterior, relative to the intact joint, throughout flexion. PCL transection also increased the amount of posterior tibial displacement measured during posterior laxity testing by up to 9.6 ± 1.7 mm at 75° (p = 0.001). During internal-external rotational laxity testing, PCL transection increased the allowable internal and external rotation of the tibia, by up to 2.9 ± 0.5°at90° (p = 0.001) and 1.0 ± 0.2° at45°(p = 0.001), respectively. PCL transection did not have a significant effect on abduction-adduction kinematics or laxity, regardless of flexion angle. PCL transection resulted in a relative posterior displacement of the tibia during the stance phase of gait when the knee was extended (2.2 ± 2.2 mm, p = 0.045), and when the knee was flexed during stair ascent (2.4 ± 2.2 mm, p = 0.035) and descent (1.6 ± 1.4 mm, p = 0.037). Our results support previous studies of the role of the PCL on neutral joint kinematics and laxity, and provide new data quantifying the effect of PCL transection on AP kinematics during simulated ADL.
Verification of mechanical load generated by functional orthodontic appliances.
Venue: Journal of biomechanics

Functional appliances are widely used for promoting mandibular growth by utilizing a construction bite position. We aimed to measure the mechanical load generated by movement of functional appliances and determine the factors influencing this load. Thirteen patients aged 8-12 years were selected for the study, and the load was measured using a previously developed measurement device. To investigate the factors affecting the load, the temporomandibular joint morphology and muscles related to the mandible were examined using cone-beam computed tomography. The standard regression coefficients of the factors affecting the load per millimeter of movement distance were 0.64 and 0.66 for (a) the inclination of the articular eminence and (b) the angle between occlusal plane and posterior temporalis, respectively. Measurement of the occlusal plane to the posterior temporalis and the inclination of the articular eminence were significantly different (p < 0.05). The angle of inclination of the articular eminence emerged as a strong influencing factor. Similarly, the influence of measurements from the occlusal plane to the posterior temporalis was considerable since the posterior temporalis muscle is the most active when the mandible is extended forward. We also found a possible relationship between the occlusal force and load at the construction bite position. To our knowledge, this is the first study to determine the actual load associated with the angle of the temporalis muscle to the occlusal plane, inclination angle of the articular eminence, angle between the occlusal plane and the Frankfort plane, and the angle between the geniohyoid muscle and the occlusal plane. Therefore, mechanical considerations need to be more accurate to facilitate safe orthodontic treatment.