nils-herrmann/clean_scirepeval huggingface dataset:
Quantification of the errors associated with marker occlusion in stereophotogrammetric systems and implications on gait analysis.
Venue: Journal of biomechanics

Optoelectronic stereophotogrammetric systems (OSSs) represent the standard for gait analysis. Despite widespread, their reported accuracy in nominal working conditions shows a variability of several orders of magnitude, ranging from few microns to several millimetres. No clear explanation for this variability has been provided yet. We hypothesized that this reflects an error affecting OSS outcomes when some of the tracked markers are totally or partially occluded. The aim of this paper is to quantify this error in static and dynamic conditions, also distinguishing between total and partial marker occlusion. A Vicon system featuring 8 cameras is employed in this study. Two camera distributions, one designed to maximize OSS accuracy and another one representative of a typical gait setup, are investigated. For both the setups, static and dynamic tests are performed, evaluating the different impact of partial and total marker occlusions. Marker occlusions significantly affected the system performances. The maximum measure variation reached 1.86 mm and 7.20 mm in static and dynamic conditions, respectively, both obtained in the case of partial occlusion. This systematic source of error is likely to affect gait measures: markers placed on the patient body are often visible only by half of the cameras, with swinging arms and legs providing moving occlusions. The maximum error observed in this study can potentially affect the kinematics outcomes of conventional gait models, particularly on frontal and coronal plane, and consequently the peak muscle forces estimated with musculoskeletal models.
Microscale strain mapping demonstrates the importance of interface slope in the mechanics of cartilage repair.
Venue: Journal of biomechanics

Achieving lateral integration of articular cartilage repair tissue with surrounding native cartilage remains a clinical challenge. Histological and bulk mechanical studies have identified extracellular matrix components that correlate with superior failure strength, but it is unclear how local changes in geometry and composition at the repair interface affect tissue strains under physiologic loading. Here, we investigated the effects of local compositional and interface geometry on lateral cartilage repair integration by coupling microscale Raman spectroscopy and confocal elastography to measure tissue strains under compressive and shear loading. Histological integration assessments did not have significant relationships with interface strains under compressive loading (p > 0.083) and only the perimeter attachment score was trending towards statistical significance with the |Exy| strain tensor under shear loading (p = 0.050). Interface slope had a stronger correlation with local tissue strains under compressive and shear loading compared to compositional measures of GAG, collagen, or proteins (compressive loading |Eyy| tensor: R2 = 0.400 (interface slope), 0.005 (GAG), 0.024 (collagen), and 0.012 (protein); shear loading |Exy| tensor: R2 = 0.457 (interface slope), 0.003 (GAG), 0.006 (collagen), and 0.000 (total protein)). These data support surgical publications detailing the need for vertical walls when debriding chondral defects. Current histological integration assessments and local compositional measures were insufficient for identifying the variation in interface strains under compressive and shear loading. Thus, our data points to the importance of controlling interface geometry at the time of surgery, which has implications for cartilage repair integration and long-term healing.
Development of a novel real-time simulation of human skeleton/muscles.
Venue: Journal of biomechanics

The objective of this research work was to develop a model of human skeleton with the capability of real-time simulation of the physical movements of a person in front of the motion capture hardware (Kinect) in order to analyze the motion data and measure the changes of joint torques. Mevea simulation software has been utilized for this purpose, which is a novel application of this software in the field of biomechanics. The model of the human skeleton was created in Mevea using the graphics built in 3ds Max. Simulink external interface for Mevea was established. Simulink acts as a connection between the Mevea software and Kinect for controlling the model. The developed model has been tested through three case studies involving the elbow joint, thoracic joint, and full body. Changes in torque and angular position of joints based on the input of joints are presented as graphs. The developed real-time model of the human skeleton in Mevea can execute the real-time simulation of a person's movements in front of a motion capture camera and provide the changes of torques, which are dependent on the angular positions of the body joints. This work provides the possibility to use the developed real-time model for physiotherapeutic rehabilitation to identify problematic muscles based on produced torque of the joints in order to specify the therapeutic options. The future research direction would be creating a reference databank by measuring healthy individuals' muscle forces for comparison purposes.
Anatomical and principal axes are not aligned in the torso: Considerations for users of geometric modelling methods.
Venue: Journal of biomechanics

The accuracy and accessibility of methods to calculate body segment inertial parameters are a key concern for many researchers. It has recently been demonstrated that the magnitude and orientation of principal moments of inertia are crucial for accurate dynamic models. This is important to consider given that the orientation of principal axes is fixed for the majority of geometric and regression body models. This paper quantifies the effect of subject specific geometry on the magnitude and orientation of second moments of volume in the trunk segment. The torsos of 40 male participants were scanned using a 3D imaging system and the magnitude and orientation of principal moments of volume were calculated from the resulting geometry. Principal axes are not aligned with the segment co-ordinate system in the torso segment, with mean Euler angles of 11.7, 1.9 and 10.3 in the ZXY convention. Researchers using anatomical modelling techniques should try and account for subject specific geometry and the mis-alignment of principal axes. This will help to reduce errors in simulation by mitigating the effect of errors in magnitude of principal moments.
Characterization and finite element validation of transchondral strain in the human hip during static and dynamic loading.
Venue: Journal of biomechanics

Distribution of strain through the thickness of articular cartilage, or transchondral strain, is highly dependent on the geometry of the joint involved. Excessive transchondral strain can damage the solid matrix and ultimately lead to osteoarthritis. Currently, high-resolution transchondral strain distribution is unknown in the human hip. Thus, knowledge of transchondral strain patterns is of fundamental importance to interpreting the patterns of injury that occur in prearthritic hip joints. This study had three main objectives. We sought to 1) quantify high-resolution transchondral strain in the native human hip, 2) determine differences in transchondral strain between static and dynamic loading conditions to better understand recovery and repressurization of cartilage in the hip, and 3) create finite element (FE) models of the experimental testing to validate a modeling framework for future analysis. The transchondral strain patterns found in this study provide insight on the localization of strain within cartilage of the hip. Most notably, the chondrolabral junction experienced high tensile and shear strain across all samples, which explains clinical data reporting it as the most common region of damage in cartilage of the hip. Further, the representative FE framework was able to match the experimental static results and predict the dynamic results with very good agreement. This agreement provides confidence for both experimental and computational measurement methods and demonstrates that the specific anisotropic biphasic FE framework used in this study can both describe and predict the experimental results.
The effect of body configuration on the strain magnitude and distribution within the acetabulum during sideways falls: A finite element approach.
Venue: Journal of biomechanics

While the incidence of hip fractures has declined during the last decades, the incidence of acetabular fractures resulting from low-energy sideways falls has increased, and the mechanisms responsible for this trend remain unknown. Previous studies have suggested that body configuration during the impact plays an important role in a hip fracture. Thus, the aim of this study was to investigate the effect of body configuration angles (trunk tilt angle, trunk flexion angle, femur horizontal rotation angle, and femur diaphysis angle) on low-energy acetabular fractures via a parametric analysis. A computed tomography-based (CT) finite element model of the ground-proximal femur-pelvis complex was created, and strain magnitude, time-history response, and distribution within the acetabulum were evaluated. Results showed that while the trunk tilt angle and femur diaphysis angle have the greatest effect on strain magnitude, the direction of the fall (lateral vs. posterolateral) contributes to strain distribution within the acetabulum. The results also suggest that strain level and distribution within the proximal femur and acetabulum resulting from a sideways fall are not similar and, in some cases, even opposite. Taken together, our simulations suggest that a more horizontal trunk and femoral shaft at the impact phase can increase the risk of low-energy acetabular fractures.
Muscle and tendon stiffness and belly gearing positively correlate with rate of torque development during explosive fixed end contractions.
Venue: Journal of biomechanics

We combined ultrafast-ultrasound with dynamometric measurements to assess the associations between muscle structural properties and the rate of torque development (RTD) during isometric explosive fixed-end plantar flexor contractions. The torque-time signal was recorded for the plantaflexor muscles in fifteen men and the peak value of RTD was obtained. Tendon stiffness (kT) and muscle stiffness (kM) of the Gastrocnemius Medialis (GM) were assessed during maximal isometric voluntary contractions (MVC) and quick release using ultrafast ultrasound (1000 Hz). During the explosive contraction, the GM geometrical changes were recorded and the belly gearing (belly velocity/fascicle velocity) was calculated. Pearson's correlation coefficient was used to assess the correlation between variables, whereas equality of correlation coefficients between RTD and kT and kM was tested by means of the Hotelling's statistics. During explosive contraction, kT was higher than kM (~55 and ~30 N⋅mm-1, respectively). RTD positively correlated with kM (r = 0.75, p < 0.001), kT (r = 0.58, p = 0.044) and belly gearing (r = 0.78, p < 0.001). However, Hotelling's test showed no significant differences between the correlation coefficients between RTD and muscle and tendon stiffness. Further, belly gearing was significantly positively correlated with kM only (r = 0.79, p < 0.001). Our data suggest that muscle and tendon stiffness are similarly associated with RTD. Given the association with belly gearing, muscle stiffness seems to play an important role in determining the muscle length changes, thereby affecting the muscle force transmission capacity during the transient phases.
Comparison of material models for anterior cruciate ligament in tension: from poroelastic to a novel fibril-reinforced nonlinear composite model.
Venue: Journal of biomechanics

Computational models of the knee joint are useful for evaluating stresses and strains within the joint tissues. However, the outcome of those models is sensitive to the material model and material properties chosen for ligaments, the collagen reinforced tissues connecting bone to bone. The purpose of this study was to investigate different compositionally motivated material models and further to develop a model that can accurately reproduce experimentally measured stress-relaxation data of bovine anterior cruciate ligament (ACL). Tensile testing samples were extracted from ACLs of bovine knee joints (N = 10) and subjected to a three-step stress-relaxation test at the toe region. Data from the experiments was averaged and one average finite element model was generated to replicate the experiment. Poroelastic and different fibril-reinforced poro(visco)elastic material models were applied, and their material parameters were optimized to reproduce the experimental force-time response. Material models with only fluid flow mediated relaxation were not able to capture the stress-relaxation behavior (R2 = 0.806, 0.803 and 0.938). The inclusion of the viscoelasticity of the fibrillar network improved the model prediction (R2 = 0.978 and 0.976), but the complex stress-relaxation behavior was best captured by a poroelastic model with a nonlinear two-relaxation-time strain-recruited viscoelastic fibrillar network (R2 = 0.997). The results suggest that in order to replicate the multi-step stress-relaxation behavior of ACL in tension, the fibrillar network formulation should include the complex nonlinear viscoelastic phenomena.
Mechanobiological evaluation of prostate cancer metastasis to bone using an in vitro prostate cancer testbed.
Venue: Journal of biomechanics

Prostate cancer exhibits a propensity to metastasize to the bone, which often leads to fatality. Bone metastasis is characterized by complex biochemical, morphological, pathophysiological, and genetic changes to cancer cells as they colonize at bone sites. In this study, we report the evaluation of MDA PCa2b prostate cancer cells' nanomechanical properties during the mesenchymal-to-epithelial transition (MET) and during disease progression at the metastatic site. Bone-mimetic tissue-engineered 3D nanoclay scaffolds have been used to create in vitro metastatic site for prostate cancer. A significant softening of the prostate cancer cells during MET and further softening as disease progression occurs at metastasis is also reported. The significant reduction in elastic modulus of prostate cancer cells during MET was attributed to actin reorganization and depolymerization. This study provides input towards direct nanomechanical measurements to evaluate the time evolution of cells' mechanical behavior in tumors at bone metastasis site.
Reliable and clinically applicable gait event classification using upper body motion in walking and trotting horses.
Venue: Journal of biomechanics

Objectively assessing horse movement symmetry as an adjunctive to the routine lameness evaluation is on the rise with several commercially available systems on the market. Prerequisites for quantifying such symmetries include knowledge of the gait and gait events, such as hoof to ground contact patterns over consecutive strides. Extracting this information in a robust and reliable way is essential to accurately calculate many kinematic variables commonly used in the field. In this study, optical motion capture was used to measure 222 horses of various breeds, performing a total of 82 664 steps in walk and trot under different conditions, including soft, hard and treadmill surfaces as well as moving on a straight line and in circles. Features were extracted from the pelvis and withers vertical movement and from pelvic rotations. The features were then used in a quadratic discriminant analysis to classify gait and to detect if the left/right hind limb was in contact with the ground on a step by step basis. The predictive model achieved 99.98% accuracy on the test data of 120 horses and 21 845 steps, all measured under clinical conditions. One of the benefits of the proposed method is that it does not require the use of limb kinematics making it especially suited for clinical applications where ease of use and minimal error intervention are a priority. Future research could investigate the extension of this functionality to classify other gaits and validating the use of the algorithm for inertial measurement units.
Reconstruction of proximal humeral fractures without screws using a reinforced bone substitute.
Venue: Journal of biomechanics

Multi-fragment fractures are still a challenge: current clinical practice relies on plates and screws. Treatment of fractures of the proximal humerus has the intra-operative risk of articular damage when inserting multiple screws. Distal-varus collapse of the head is a frequent complication in osteoporotic patients. The aim of this biomechanical study was to investigate if an Innovative-cement-technique (the screws are replaced by injection of cement) provides the same or better stability of the reconstructed head compared to the Standard-technique (locking screws). A four-fragment fracture was simulated in twelve pairs of humeri, with removal of part of the cancellous bone to simulate osteoporotic "eggshell" defect. One humerus of each pair was repaired either with a Standard-technique (locking plate, 2 cortical and 6 locking screws), or with the Innovative-cement-technique (injection of a partially-resorbable reinforced bone substitute consisting of PMMA additivated with 26% beta-TCP). Cement injection was performed both in the lab and under fluoroscopic monitoring. The reconstructed specimens were tested to failure with a cyclic force of increasing amplitude. The Innovative-cement-technique withstood a force 3.57 times larger than the contralateral Standard reconstructions before failure started. The maximum force before final collapse for the Innovative-cement-technique was 3.56 times larger than the contralateral Standard-technique. These differences were statistically significant. The Innovative-cement-technique, based on the reinforced bone substitute, demonstrated better biomechanical properties compared to the Standard-technique. These findings, along with the advantage of avoiding the possible complications associated with the locking screws, may help safer and more effective treatment in case of osteoporotic multi-fragment humeral fractures.
Sex- and injury-based differences in knee biomechanics in mouse models of post-traumatic osteoarthritis.
Venue: Journal of biomechanics

Sex and joint injury are risk factors implicated in the onset and progression of osteoarthritis (OA). In mouse models of post-traumatic OA (ptOA), the pathogenesis of disease is notably impacted by sex (often worse in males) and injury model (e.g. meniscal versus ligament injury). Increasing ptOA progression and severity is often associated with greater relative instability of the joint but few studies have directly quantified changes in joint mechanics after injury and compared outcomes across multiple models in both male and female mice. Passive anterior-posterior knee biomechanics were evaluated in 10-week-old, male and female C57BL/6J mice. PtOA injury models included destabilisation of the medial meniscus (DMM), anterior cruciate ligament transection (ACLT) or mechanical rupture (ACLR), and combined DMM and ACLT (DMM + ACLT). Sham operated and non-operated controls (NOC) were included for baseline comparisons. The test apparatus loaded hindlimbs at 60° flexion between ± 1 N at 0.5 mm/s (build specifications available for download: https://doi.org/10.17632/z754455x3c.1). Measures of joint laxity (range of motion, neutral zone) and stiffness were calculated. Joint laxity was comparable between male and female mice while joint stiffness was greater in females (P ≤ 0.002, correcting for body-mass and injury-model). Anterior-posterior joint mechanics were minimally altered by DMM but significantly affected by loss of the ACL (P < 0.001), with equivalent changes between ACL-injury models despite different injury mechanisms and adjacent meniscal damage. These findings suggest that despite the important role of joint injury; sex- and model-specific differences in ptOA progression and severity are not primarily driven by altered anterior-posterior knee biomechanics.
Trunk control during gait: Walking with wide and narrow step widths present distinct challenges.
Venue: Journal of biomechanics

The active control of the trunk plays an important role in frontal plane gait stability. We characterized trunk control in response to different step widths using a novel feedback system and examined the different effects of wide and narrow step widths as they each present unique task demands. Twenty healthy young adults walked on a treadmill at 1.25 m/s at five prescribed step widths: 0.33, 1.67, 1, 1.33, 1.67 times preferred step width. Motion capture was used to record trunk kinematics, and surface electromyography was used to record longissimus muscle activation bilaterally. Vector coding was used to analyze coordination between pelvis and thorax segments of the trunk. Results showed that while center of mass only varied across step width in the mediolateral direction, trunk kinematics in all three planes were affected by changes in step width. Angular excursions of the trunk segments increased only with wider widths in the transverse plane. Thorax-pelvis kinematic coordination was affected more by wider widths in transverse plane and by narrower widths in the frontal plane. Peak longissimus activation and bilateral co-activation increased as step widths became narrower. As a control task, walking with varied step widths is not simply a continuum of adjustments from narrow to wide. Rather, narrowing step width and widening step width from the preferred width represent distinct control challenges that are managed in different ways. This study provides foundation for future investigations on the trunk during gait in different populations.
A novel walking cane with haptic biofeedback reduces knee adduction moment in the osteoarthritic knee.
Venue: Journal of biomechanics

Knee osteoarthritis is a leading cause of ambulatory disability in adults. The most prescribed mobility aid, the walking cane, is often underloaded and therefore fails to reduce knee joint loading and provide symptomatic relief. For this study, a novel walking cane with haptic biofeedback was designed to improve cane loading and reduce the knee adduction moment (KAM). To determine; 1) the short-term efficacy of a novel walking cane using haptic biofeedback to encourage proper cane loading and 2) the effects of the novel cane on KAM. Cane loading and KAM, peak knee adduction moment (PKAM), and knee adduction angular impulse (KAAI)) while walking were calculated under five conditions: 1) naïve, 2A) after scale training (apply 20%BW to cane while standing, using a beam scale), 2B) scale recall (attempt to load the cane to 20%BW), 3A) after haptic training (vibrotactile biofeedback delivered when target cane load achieved), and 3B) haptic recall (attempt to load the cane to 20%BW with vibrotactile biofeedback delivered). Compared to the naïve condition all interventions significantly increased cane loading and reduced PKAM and KAAI. No differences between haptic recall and scale recall condition were observed. The haptic biofeedback cane was shown to be an effective and simple way to increase cane loading and reduced knee loading. Haptic biofeedback and scale training were equally effective at producing immediate short-term improvements in cane loading and knee loading. Future studies should examine the long-term effects of scale training and canes with haptic biofeedback on knee joint health, pain, and osteoarthritis disease progression.