nils-herrmann/clean_scirepeval huggingface dataset:
The influence of soft tissue artifacts on multi-segment foot kinematics.
Venue: Journal of biomechanics

Movement of skin markers with respect to their underlying bone (i.e. soft tissue artifacts (STAs)) might corrupt the accuracy of marker-based movement analyses. This study aims to quantify STAs in 3D for foot markers and their effect on multi-segment foot kinematics as calculated by the Oxford and Rizzoli Foot Models (OFM, RFM). Fifteen subjects with asymptomatic feet were seated on a custom-made loading device on a computed tomography (CT) table, with a combined OFM and RFM marker set on their right foot. One unloaded reference CT-scan with neutral foot position was performed, followed by 9 loaded CT-scans at different foot positions. The 3D-displacement (i.e. STA) of each marker in the underlying bone coordinate system between the reference scan and other scans was calculated. Subsequently, segment orientations and joint angles were calculated from the marker positions according to OFM and RFM definitions with and without STAs. The differences in degrees were defined as the errors caused by the marker displacements. Markers on the lateral malleolus and proximally on the posterior aspect of the calcaneus showed the largest STAs. The hindfoot-shank joint angle was most affected by STAs in the most extreme foot position (40° plantar flexion) in the sagittal plane for RFM (mean: 6.7°, max: 11.8°) and the transverse plane for OFM (mean: 3.9°, max: 6.8°). This study showed that STAs introduce clinically relevant errors in multi-segment foot kinematics. Moreover, it identified marker locations that are most affected by STAs, suggesting that their use within multi-segment foot models should be reconsidered.
Upper body contributions to pitched ball velocity in elite high school pitchers using an induced velocity analysis.
Venue: Journal of biomechanics

Interest in joint and segment contributions to pitched ball velocity has been dominated by inverse dynamic solutions, which is limited in ascertaining complex muscle/joint interactions. Our purpose was to use induced velocity analysis to investigate which joint(s) made the largest contribution to the velocity of a pitched ball. Pitching data were collected from six elite high school-aged pitchers with no history of arm injury. Participants threw a fastball pitch from the windup on flat ground. Data were collected using seven Vicon 612 cameras (250 Hz) and three AMTI force platforms (1000 Hz). A 14-segment biomechanical model (feet, legs, thighs, pelvis, a combined thorax-abdomen-head, i.e., trunk, upper arms, forearms, and hands) was implemented in Visual3D as a dynamic link library built using SD/Fast (PTC) software. Model-generated induced velocity of the ball was validated against ball velocity obtained from a calibrated radar gun. Velocity induced torques at the shoulder just prior to release, and elbow during the cocking phase, contributed 31.0% and 18.1%, respectively, to forward ball velocity. The centripetal/Coriolis effects from the upper arm and forearm velocities made the largest contribution to ball velocity (average 57.8%), but the source of these effects are unknown. The lower extremities and trunk made little direct contribution to pitched ball velocity. These results may have implications with regard to pitching performance enhancement and rehabilitation.
Effects of local coronary blood flow dynamics on the predictions of a model of in-stent restenosis.
Venue: Journal of biomechanics

Computational models are increasingly used to study cardiovascular disease. However, models of coronary vessel remodelling usually make some strong assumptions about the effects of a local narrowing on the flow through the narrowed vessel. Here, we test the effects of local flow dynamics on the predictions of an in-stent restenosis (ISR) model. A previously developed 2D model of ISR is coupled to a 1D model of coronary blood flow. Then, two different assumptions are tested. The first assumption is that the vasculature is always able to adapt, and the volumetric flow rate through the narrowed vessel is kept constant. The second, alternative, assumption is that the vasculature does not adapt at all, and the ratio of the pressure drop to the flow rate (hydrodynamic resistance) stays the same throughout the whole process for all vessels unaffected by the stenosis, and aortic or venous blood pressure does not change either. Then, the dynamics are compared for different locations in coronary tree for two different reendothelization scenarios. The assumptions of constant volumetric flow rate (absolute vascular adaptation) versus constant aortic pressure drop and no adaptation do not significantly affect the growth dynamics for most locations in the coronary tree, and the differences can only be observed at the locations where a strong alternative flow pathway is present. On the other hand, the difference between locations is significant, which is consistent with small vessel size being a risk factor for restenosis. These results suggest that the assumption of a constant flow is a good approximation for ISR models dealing with the typical progression of ISR in the most often stented locations such as the proximal parts of left anterior descending (LAD) and left circumflex (LCX) arteries.
Deformation mechanics of self-expanding venous stents: Modelling and experiments.
Venue: Journal of biomechanics

Deformation properties of venous stents based on braided design, chevron design, Z design, and diamond design are compared using in vitro experiments coupled with analytical and finite element modelling. Their suitability for deployment in different clinical contexts is assessed based on their deformation characteristics. Self-expanding stainless steel stents possess superior collapse resistance compared to Nitinol stents. Consequently, they may be more reliable to treat diseases like May-Thurner syndrome in which resistance against a concentrated (pinching) force applied on the stent is needed to prevent collapse. Braided design applies a larger radial pressure particularly for vessels of diameter smaller than 75% of its nominal diameter, making it suitable for a long lesion with high recoil. Z design has the least foreshortening, which aids in accurate deployment. Nitinol stents are more compliant than their stainless steel counterparts, which indicates their suitability in veins. The semi-analytical method presented can aid in rapid assessment of topology governed deformation characteristics of stents and their design optimization.
Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
Venue: Journal of biomechanics

The meniscus is crucial in maintaining the knee function and protecting the joint from secondary pathologies, including osteoarthritis. Although most of the mechanical properties of human menisci have been characterized, to our knowledge, its dynamic shear properties have never been reported. Moreover, little is known about meniscal shear properties in relation to tissue structure and composition. This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue. Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition. Specimens were prepared from the axial and the circumferential anatomical planes of medial and lateral menisci. Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G). Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated. The meniscus exhibited viscoelastic behavior. Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples). Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively. Fiber orientation did not affect the values of G, which ranged from ~50 to ~100 kPa.
Spine and pelvis coordination variability in rowers with and without chronic low back pain during rowing.
Venue: Journal of biomechanics

The aim of this study was to compare the spine-pelvis coordination and coordination variability (CV) during rowing in elite rowers with and without chronic low back pain (CLBP). Fourteen professional rowers (6 healthy and 8 with CLBP) participated in this study. 3D kinematic of upper trunk (UT), lower trunk (LT), lower back (LB), and pelvis segments during ergometer rowing at 70% and 100% of peak power were captured. The adjacent segments' coordination and CV were calculated using modified vector coding method. The results showed that segments' range of motion increased in both groups with increasing intensity, especially in CLBP rowers. CLBP rowers showed significantly lower: LT dominancy in LT/LB coordination at both intensities; anti-phase pattern in LB/Pelvis coordination at 100% intensity; UT/LT CV in early recovery, and significantly higher LB/Pelvis CV in final recovery and catch position (p < 0.05). Moreover, both groups showed significantly lower UT dominancy for UT/LT coordination in sagittal plane; higher anti-phase pattern in frontal plane; lower UT/LT CV in sagittal plane, lower LT/LB CV in sagittal and transverse plane, lower LB/Pelvis CV in frontal plane in trunk preparation phase, and a lower UT/LT CV in frontal plane for acceleration phase at 100% versus 70% intensity. In conclusion rowers with CLBP cannot adapt their coordination pattern and its variability with increase in intensity, and the movement in the kinematic chain from pelvis to UT stops in spine-pelvic junction. These findings have practical implications in designing coaching and rehabilitation strategies to facilitate performance and prevent injuries.
Development of axial compression and combined axial compression and torque loading configurations to reproduce strain in the implanted femur during activities of daily living.
Venue: Journal of biomechanics

Femoral strain is indicative of the potential for bone remodeling (strain energy density, SED) and periprosthetic femoral fracture (magnitude of principal strains) after total hip arthroplasty (THA). Previous modeling studies have evaluated femoral strains in THA-implanted femurs under gait loads including both physiological hip contact force and femoral muscle forces. However, experimental replication of the complex muscle forces during activities of daily living (ADLs) is difficult for in vitro assessment of femoral implant or fixation hardware. Alternatively, cadaveric tests using simplified loading configurations have been developed to assess post-THA bone mechanics, although no current studies have demonstrated simplified loading configurations used in mechanical tests may simulate the physiological femoral strains under ADL loads. Using an optimization approach integrated with finite element analysis, this study developed axial compression and combined axial compression and torque testing configurations for three common ADLs (gait, stair-descent and sit-to-stand) via matching the SED profile of the femur in THA-implanted models of three specimens. The optimized simplified-loading models showed good agreement in predicting bone remodeling stimuli (post-THA change in SED per unit mass) and fatigue regions as compared with the ADL-loading models, as well as other modeling and clinical studies. The optimized simplified test configurations can provide a physiological-loading based pre-clinical platform for the evaluation of implant/fixation devices of the femur.
Obstacle avoidance training in virtual environments leads to limb-specific locomotor adaptations but not to interlimb transfer in healthy young adults.
Venue: Journal of biomechanics

Obstacle avoidance is one of the skills required in coping with challenging situations encountered during walking. This study examined adaptation in gait stability and its interlimb transfer in a virtual obstacle avoidance task. Twelve young adults walked on a treadmill while wearing a virtual reality headset with their body state represented in the virtual environment. At random times, but always at foot touchdown, 50 virtual obstacles of constant size appeared 0.8 m in front of the participant requiring a step over with the right leg. Early, mid and late adaptation phases were investigated by pooling data from trials 1-3, 24-26 and 48-50. One left-leg obstacle appearing after 50 right-leg trials was used to investigate interlimb transfer. Toe clearance and the anteroposterior margin of stability (MoS) at foot touchdown were calculated for the stepping leg. Toe clearance decreased over repeated practice between early and late phases from 0.13 ± 0.05 m to 0.09 ± 0.04 m (mean ± SD, p < 0.05). MoS increased from 0.05 ± 0.02 m to 0.08 ± 0.02 m (p < 0.05) between early and late phases, with no significant differences between mid and late phases. No differences were found in toe clearance and MoS between the practiced right leg for early phase and the single trial of the left leg. Obstacle avoidance during walking in a virtual environment stimulated adaptive gait improvements that were related in a nonlinear manner to practice dose, though such gait adaptations seemed to be limited in their transferability between limbs.
The effects of aging on the mechanical properties of the vitreous.
Venue: Journal of biomechanics

The vitreous body is a viscoelastic gel-like network that fills the space between the lens and the retina in the eye. With aging, the vitreous undergoes a liquefaction process in which liquid pockets form in the gel network, thereby motivating the detachment of the vitreous from the retina in a process known as posterior vitreous detachment (PVD). The PVD process may lead to the formation of floaters and even result in partial or complete loss of vision. Experiments show that the liquefaction and the PVD processes alter the mechanical properties of the vitreous. In this work, we propose a microscopically motivated model that characterizes the changes in the mechanical properties of the vitreous due to aging. To this end, we distinguish between four vitreous states: a homogeneous vitreous, a liquefied vitreous, a vitreous that undergoes partial PVD, and a vitreous with full PVD. The model predicts the time-dependent and the steady-state response of the vitreous in each of the four states. The proposed framework is validated through a comparison with various experimental findings and captures the softening of the vitreous due to aging. We illustrate the importance of the age at which the PVD process begins and of the rate of the detachment process. In addition, we introduce a quantifiable parameter that describes the stage of PVD in the eye. Lastly, we employ our model to investigate the possibility of restoring the mechanical properties of a vitreous that has undergone PVD through the addition of reinforcing fibers to the gel. This work provides insight into the consequences of the age-related changes in the microstructure of the eye and serves as a motivation for new therapeutic measures.
Influence of transducer orientation on shear wave velocity measurements of the iliotibial band.
Venue: Journal of biomechanics

Tissue anisotropy influences estimation of mechanical properties of connective tissues, such as the iliotibial band (ITB). This study investigated the influence of ultrasound transducer rotation and tilt on shear wave velocity (SWV, an index of stiffness) measurements of the ITB and the intra-rater repeatability of SWV measurements in the longitudinal direction. SWV was measured unilaterally (dominant limb) using ultrasound shear wave elastography in the middle region of the ITB in supine at rest (20-25° knee flexion) in ten healthy volunteers (4 females). A 3-dimensional video system provided real-time feedback of probe orientation with respect to the thigh. Measurements were made at 10° increments of probe rotation, from longitudinal to transverse alignment relative to the approximate direction of ITB fibres, and 5-10° tilts about the longitudinal and sideways axes of the transducer. One-way repeated measures ANOVA compared SWV between angles and tilts. Intraclass correlation coefficients (ICCs) and standard error of measurement (SEM) were used to calculate repeatability for two to five (longitudinal only) repetitions. SWV was greatest when the transducer was aligned to ITB fibres (longitudinal: 10.5 ± 1.7 m/s) and lowest when perpendicular (transverse: 5.8 ± 2.4 m/s). Compared to longitudinal alignment, SWV decreased significantly (p < 0.01) when the transducer was rotated 20° or more. Tilted measurements did not differ between angles. Intra-rater repeatability was excellent with the average of two measurements (ICC = 0.99, 95% CI 0.95, 0.99; SEM = 0.31 m/s). These findings show that SWV changes with orientation relative to fibre direction. Transducer orientation requires careful control to ensure comparable measures.
Mechanobiology of shear-induced platelet aggregation leading to occlusive arterial thrombosis: A multiscale in silico analysis.
Venue: Journal of biomechanics

Occlusive thrombosis in arteries causes heart attacks and strokes. The rapid growth of thrombus at elevated shear rates (~10,000 1/s) relies on shear-induced platelet aggregation (SIPA) thought to come about from the entanglement of von Willebrand factor (VWF) molecules. The mechanism for SIPA is not yet understood in terms of cell- and molecule-level dynamics in fast flowing bloodstreams. Towards this end, we develop a multiscale computational model to recreate SIPA in silico, where the suspension dynamics and interactions of individual platelets and VWF multimers are resolved directly. The platelet-VWF interaction via GP1b-A1 bonds is prescribed with intrinsic binding rates theoretically derived and informed by single-molecule measurements. The model is validated against existing microfluidic SIPA experiments, showing good agreement with the in vitro observations in terms of the morphology, traveling distance and capture time of the platelet aggregates. Particularly, the capture of aggregates can occur in a few milliseconds, comparable to the platelet transit time through pathologic arterial stenotic sections and much shorter than the time for shear-induced platelet activation. The multiscale SIPA simulator provides a cross-scale tool for exploring the biophysical mechanisms of SIPA in silico that are difficult to access with single-molecule measurements or micro-/macro-fluidic assays only.
Computational modeling to predict the micromechanical environment in tissue engineering scaffolds.
Venue: Journal of biomechanics

Cell fate in tissue engineering (TE) strategies is paramount to regenerate healthy, functional organs. The mechanical loads experienced by cells play an important role in cell fate. However, in TE scaffolds with a cell-laden hydrogel matrix, it is prohibitively complex to prescribe and measure this cellular micromechanical environment (CME). Accordingly, this study aimed to develop a finite element (FE) model of a TE scaffold unit cell that can be subsequently implemented to predict the CME and cell fates under prescribed loading. The compressible hyperelastic mechanics of a fibrin hydrogel were characterized by fitting unconfined compression and confined compression experimental data. This material model was implemented in a unit cell FE model of a TE scaffold. The FE mesh and boundary conditions were evaluated with respect to the mechanical response of a region of interest (ROI). A compressible second-order reduced polynomial hyperelastic model gave the best fit to the experimental data (C10 = 1.72 × 10-4, C20 = 3.83 × 10-4, D1 = 3.41, D2 = 8.06 × 10-2). A mesh with seed sizes of 40 µm and 60 µm in the ROI and non-ROI regions, respectively, yielded a converged model in 54 min. The in-plane boundary conditions demonstrated minimal influence on ROI mechanics for a 2-by-2 unit cell. However, the out-of-plane boundary conditions did exhibit an appreciable influence on ROI mechanics for a two bilayer unit cell. Overall, the developed unit cell model facilitates the modeling of the mechanical state of a cell-laden hydrogel within a TE scaffold under prescribed loading. This model will be utilized to characterize the CME in future studies, and 3D micromechanical criteria may be applied to predict cell fate in these scaffolds.
Jumping with barbell load: Assessment of lower limb joint kinematics and kinetics during landing.
Venue: Journal of biomechanics

Loaded jumps are commonly used to improve leg muscle power. However, the additional load during jump-landing might increase the potential for overuse injury. Therefore, the aims of this study were to evaluate the effect that barbell load has on lower limb joint kinematics and kinetics during jump-landing and to evaluate the effect of arresting the barbell load at flight apex prior to landing on joint kinematic and kinetic variables. Barbell-loaded squat jumps (20, 40, and 60 kg) were investigated during two jump-landing conditions: 1) barbell-loaded (landing with barbell load) and 2) barbell-arrested (barbell load arrested at flight apex prior to jump-landing). Lower body kinematics and joint kinetics were assessed during jump-landing. In the barbell-loaded jump-landing condition, joint angles at initial contact decreased with increasing barbell load. Knee and hip peak power decreased (knee: -38%; hip: -46%), while ankle joint work increased with increasing barbell load. Joint moments, powers and work were decreased in the barbell-arrested condition compared to the barbell-loaded condition. Barbell-loaded jump-landings do not pose increased demands on the knee and the hip joint compared to bodyweight only jump-landings, due to the load-based reductions in jump height and joint kinematic adaptions. However, ankle joint contribution in energy dissipation is increased, possibly resulting in an increased overuse injury risk at this joint. Arresting the barbell load at flight apex prior to jump-landing substantially reduces the joint kinetics, hence serving as valuable training tool for athletes returning to sport after injuries.