nils-herrmann/clean_scirepeval huggingface dataset:
The prosthetic screw loosening of two-implant supported screw-retained fixed dental prostheses in the posterior region: A retrospective evaluation and finite element analysis.
Venue: Journal of biomechanics

The study was aimed to investigate the prosthetic screw loosening of two splinted implants-supported, screw-retained (2-4-unit) fixed dental prostheses (TIS-FDPs) in posterior region and to explore the underlying mechanism. In the retrospective study, a study group of TIS-FDPs (n = 23) presenting prosthetic screw loosening and a control group of TIS-FDPs (n = 32) absent of prosthetic screw loosening during observation period were included. The prosthesis height (PH), inter-implant distance (ID) and cantilever distance (CD) of TIS-FDPs were measured and compared within two groups. In the finite element analysis (FEA) part, three serials of models presenting different clinical scenarios were constructed based on the abovementioned PH, ID and CD values respectively. In the clinical evaluation, the values of pH and CD in study group were statistically higher than those in control group, whereas the values of ID had no significant difference. In the FEA, the results indicated that there was no linear correlation between the increased ID values and the maximum von Mises stresses and the rotation angles. On the other hand, the increased PH and CD values would result in a strong linear growth of the maximum von Mises stresses and the rotation angles. Besides, it was found that the regression coefficients in PH model were all higher than those in ID and CD models. When TIS-FDPs were delivered in posterior region, the PH and the CD, rather than the ID, seemed to have a significant impact on the stress concentration of the prosthetic screws and the incident of prosthetic screws loosening.
Regional differential stretching of the pectoralis major muscle: An ultrasound elastography study.
Venue: Journal of biomechanics

Pectoralis major (PMa) muscle injuries are becoming more prevalent, and their incidence differs among the PMa regions, i.e., the clavicular, sternal, and abdominal regions. Therefore, identifying the position for effectively lengthening each PMa region is critical in preventing PMa injuries. The purpose of this study was to determine the effective stretching position for each PMa region through shear wave elastography, which can indirectly assess individual muscle lengthening. Fifteen men participated in this study. Twelve stretching positions were compounded with shoulder abductions (45°, 90°, and 135°), pelvic rotation (with or without), shoulder external rotation (with or without), and shoulder horizontal abductions. The shear modulus of each PMa region was measured through shear wave elastography in the stretching positions mentioned above. At the clavicular region, the shear modulus was higher for three stretching positions: shoulder horizontal abduction at 45° abduction during pelvic rotation and shoulder external rotation, shoulder horizontal abduction at 90° abduction, and shoulder horizontal abduction at 90° abduction while considering shoulder external rotation. For the sternal region, the shear modulus was higher in two stretching positions: shoulder horizontal abduction at 90° abduction while adding external rotation, and combination of pelvic rotation and external rotation. For the abdominal region, the shear modulus was higher in the shoulder horizontal abduction at 135° abduction with pelvic and external rotation. These results indicated that the effective stretching position was different for each PMa region.
Evaluation of orthodontic loads and wire-bracket contact configurations in a three-bracket setup: Comparison of in-vitro experiments with numerical simulations.
Venue: Journal of biomechanics

So far, no practicable procedure exists to quantify the orthodontic loads applied to teeth in vivo. Dentists therefore rely on experience and simplified mechanical in-vitro experiments comprising deflection of orthodontic wires. Predicting the mechanical behaviour of orthodontic wires during clinical therapy requires understanding of the different contact states at multi-bracket-wire interfaces. This study experimentally investigates the effect of different bracket-wire contact configurations in a three-bracket setup and uses two numerical approaches to analyse and complement the experimental data. Commonly used round stainless-steel wires (diameter: 0.012″ and 0.016″) and titanium-molybdenum alloy wires (diameter: 0.016″ and 0.018″) were tested. All six force-moment components were measured separately for each of the three brackets. The results indicate that a specific sequence of distinct bracket-wire contact configurations occurs. Several transitions between configurations caused substantial changes of effective wire stiffness (EWS), which were consistent among experimental and numerical methods. The lowest EWS was observed for the configuration in which the wire touched only one wing of the lateral brackets. Taking this stiffness as 100%, the transition to a configuration in which the wire touched two opposing wings of the lateral brackets resulted in an increase of EWS of 300% ± 10%. This increase was independent of the wire type. Additional contacts resulted in further increases of stiffness beyond 400%. The results of this combined experimental and numerical study are important for providing a fundamental understanding of multi-bracket-wire contact configurations and have important implications for clinical therapy.
Reliability of measures to characterize lumbar movement patterns, in repeated seated reaching, in a mixed group of participants with and without low-back pain: A test-retest, within- and between session.
Venue: Journal of biomechanics

Literature highlights the need for research on changes in lumbar movement patterns, as potential mechanisms underlying the persistence of low-back pain. Variability and local dynamic stability are frequently used to characterize movement patterns. In view of a lack of information on reliability of these measures, we determined their within- and between-session reliability in repeated seated reaching. Thirty-six participants (21 healthy, 15 LBP) executed three trials of repeated seated reaching on two days. An optical motion capture system recorded positions of cluster markers, located on the spinous processes of S1 and T8. Movement patterns were characterized by the spatial variability (meanSD) of the lumbar Euler angles: flexion-extension, lateral bending, axial rotation, temporal variability (CyclSD) and local dynamic stability (LDE). Reliability was evaluated using intraclass correlation coefficients (ICC), coefficients of variation (CV) and Bland-Altman plots. Sufficient reliability was defined as an ICC ≥ 0.5 and a CV < 20%. To determine the effect of number of repetitions on reliability, analyses were performed for the first 10, 20, 30, and 40 repetitions of each time series. MeanSD, CyclSD, and the LDE had moderate within-session reliability; meanSD: ICC = 0.60-0.73 (CV = 14-17%); CyclSD: ICC = 0.68 (CV = 17%); LDE: ICC = 0.62 (CV = 5%). Between-session reliability was somewhat lower; meanSD: ICC = 0.44-0.73 (CV = 17-19%); CyclSD: ICC = 0.45-0.56 (CV = 19-22%); LDE: ICC = 0.25-0.54 (CV = 5-6%). MeanSD, CyclSD and the LDE are sufficiently reliable to assess lumbar movement patterns in single-session experiments, and at best sufficiently reliable in multi-session experiments. Within-session, a plateau in reliability appears to be reached at 40 repetitions for meanSD (flexion-extension), meanSD (axial-rotation) and CyclSD.
Simulation of preoperative flexion contracture in a computational model of total knee arthroplasty: Development and evaluation
Venue: Journal of biomechanics

Preoperative flexion contracture is a risk factor for patient dissatisfaction following primary total knee arthroplasty (TKA). Previous studies utilizing surgical navigation technology and cadaveric models attempted to identify operative techniques to correct knees with flexion contracture and minimize undesirable outcomes such as knee instability. However, no consensus has emerged on a surgical strategy to treat this clinical condition. Therefore, the purpose of this study was to develop and evaluate a computational model of TKA with flexion contracture that can be used to devise surgical strategies that restore knee extension and to understand factors that cause negative outcomes. We developed six computational models of knees implanted with a posteriorly stabilized TKA using a measured resection technique. We incorporated tensions in the collateral ligaments representative of those achieved in TKA using reference data from a cadaveric experiment and determined tensions in the posterior capsule elements in knees with flexion contracture by simulating a passive extension exam. Subject-specific extension moments were calculated and used to evaluate the amount of knee extension that would be restored after incrementally resecting the distal femur. Model predictions of the extension angle after resecting the distal femur by 2 and 4 mm were within 1.2° (p ≥ 0.32) and 1.6° (p ≥ 0.25), respectively, of previous studies. Accordingly, the presented computational method could be a credible surrogate to study the mechanical impact of flexion contracture in TKA and to evaluate its surgical treatment.
The association of breast cancer-related lymphedema after unilateral mastectomy with shoulder girdle kinematics and upper extremity function.
Venue: Journal of biomechanics

The purpose of this study was to examine the association of breast cancer-related lymphedema on shoulder girdle kinematics and upper extremity function. The study included 67 breast cancer survivors with and without unilateral lymphedema. Individuals were divided into non-lymphedema, moderate and severe lymphedema groups according to the volumetric measurement difference between the affected and unaffected upper extremities. A three-dimensional motion monitor-electromagnetic system was used to analyze scapular movements during the elevation and depression phases of the upper extremity elevation in the scapular plane. Shoulder range of motion was assessed with a digital inclinometer. Upper extremity function was assessed with the 'Disabilities of the Arm, Shoulder, and Hand Questionnaire-Short Form (Quick-DASH)'. The scapular upward rotation was lower for the severe lymphedema group than for the non-lymphedema group in the 90-60-30° depression phases of arm elevation (p < .05). The scapular anterior tilt was higher for the severe lymphedema group than for the non-lymphedema group in the 30° depression phase of arm elevation (p < .05). Shoulder abduction range of motion was the lowest in the severe lymphedema group (p < .05). The non-lymphedema group had the lowest quick-DASH score and the severe lymphedema group had the highest score (p < .05). There were statistically significant moderate associations between the quick-DASH scores and scapular movements in all groups (p < .05). The development, presence and/or severity of lymphedema were associated with impaired shoulder-girdle kinematics and decreased upper extremity function. However, a need exists for longitudinal studies comparing individuals with and without lymphedema and healthy controls.
Directional differences in head stabilisation in Acanthodactylus pardalis lizards.
Venue: Journal of biomechanics

Running inevitably causes the animal trunk to undulate. The consequential head rotations have to be stabilised in space for a steady gaze and an accurate sense of self-motion for balance. The ecology and anatomy of the species determine the necessity to stabilise the head in yaw, pitch, and roll direction. Terrestrial lizards, running with a sprawled body posture, are especially prone to undulations in the horizontal (yaw) plane. Measurements on an experimental oscillation platform show that Acanthodactylus pardalis lizards stabilise their head less in pitch direction (54% stabilisation) than in yaw and roll direction (66% and 64% stabilisation, respectively). Because we performed these experiments in darkness, the lizards based their head stabilisation on vestibular information. Hence, we hypothesised that their vestibular system is less sensitive in pitch direction than in yaw and roll direction. Yet, this was not confirmed by a detailed Fluid-Structure Interaction model of the membranous labyrinth, which showed that not pitch sensitivity (88% of yaw sensitivity), but roll sensitivity (73% of yaw sensitivity) is the lowest. So why is the head stabilisation in darkness almost as good in roll direction as in yaw direction? While this may be due to neurological nonlinearities, it seems worth noticing that the moment of inertia is lowest in roll direction due to the elongated head shape. Hence, less torque is needed to stabilise a head rotation in roll direction than in the other two directions.
Tumor cell nuclei soften during transendothelial migration.
Venue: Journal of biomechanics

During cancer metastasis, tumor cells undergo significant deformation in order to traverse through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow gaps, smaller than the nuclear diameter, the spatial configuration of chromatin must change along with the distribution of nuclear enzymes. Nuclear stiffness is an important determinant of the ability of cells to undergo transendothelial migration, yet no studies have been conducted to assess whether tumor cell cytoskeletal or nuclear stiffness changes during this critical process in order to facilitate passage. To address this question, we employed two non-contact methods, Brillouin confocal microscopy (BCM) and confocal reflectance quantitative phase microscopy (QPM), to track the changes in mechanical properties of live, transmigrating tumor cells in an in vitro collagen gel platform. Using these two imaging modalities to study transmigrating MDA-MB-231, A549, and A375 cells, we found that both the cells and their nuclei soften upon extravasation and that the nuclear membranes remain soft for at least 24 h. These new data suggest that tumor cells adjust their mechanical properties in order to facilitate extravasation.
Levodopa facilitates improvements in gait kinetics at the hip, not the ankle, in individuals with Parkinson's disease.
Venue: Journal of biomechanics

Parkinson's disease symptoms impair gait, limit mobility, and reduce independence. Levodopa improves muscle activation, strength, and coordination; thus, facilitating increased step length, but few studies have evaluated the underlying forces associated with medication-induced gait improvements. Here, we assess the effects of levodopa on gait kinetics in persons with Parkinson's disease. Over two sessions, 13 participants with Parkinson's disease walked on a treadmill while both optimally medicated and after a 12-hour medication withdrawal. Walking was analyzed for spatiotemporal parameters, ranges of motion, anterior-posterior ground reaction forces, joint torques, and powers using an instrumented treadmill and motion capture system. When on medication, participants increased gait speed by significantly improving step length (p = .009) and time (p = .004). Peak propulsive force (p = .001) and hip flexion torques (p = .003) increased with medication while hip extensor and ankle plantarflexor torques did not. While differences in joint power were not significantly different, the optimal medication condition showed medium to large effects, with the largest effect at the hip (dz = 0.84). Our findings suggest the underlying forces responsible for the increases in gait speed are primarily due to increases at the hip, with limited change at the ankle. Disproportionate use of muscle force may be a limiting factor for levodopa's use as an intervention for walking. Future interventions should consider targeting force production deficits during gait in those with Parkinson's disease.
Inter-session repeatability of markerless motion capture gait kinematics.
Venue: Journal of biomechanics

The clinical uptake and influence of gait analysis has been hindered by inherent limitations of marker-based motion capture systems, which have long been the standard method for the collection of gait data including kinematics. Markerless motion capture offers an alternative method for the collection of gait kinematics that presents several practical benefits over marker-based systems. This work aimed to determine the reliability of lower limb gait kinematics from video based markerless motion capture using an established experimental protocol for testing reliability. Eight healthy adult participants performed three sessions of five over-ground walking trials in their own self-selected clothing, separated by an average of 8.5 days, while eight synchronized and calibrated cameras recorded video. Three-dimensional pose estimates from the video data were used to compute lower limb joint angles. Inter-session variability, inter-trial variability, and the variability ratio were used to assess the reliability of the gait kinematics. Compared to repeatability studies based on marker-based motion capture, inter-trial variability was slightly greater than previously reported for some angles, with an average across all joint angles of 2.5°. Inter-session variability was smaller on average than all previously reported values, with an average across all joint angles of 2.8°. Variability ratios were all smaller than those previously reported with an average of 1.1, indicating that the multi-session protocol increased the total variability of joint angles by 10% of the inter-trial variability. These results indicate that gait kinematics can be reliably measured using markerless motion capture.
Embedded 3D printing of multi-layer, self-oscillating vocal fold models.
Venue: Journal of biomechanics

The biomechanics of human voice production are commonly studied using benchtop silicone vocal fold models that mimic the vibration of their in vivo counterparts. These models often have multiple layers of differing stiffness that represent human vocal fold tissue layers and are fabricated using a multi-step casting process. The purpose of the present study is to introduce and demonstrate a process for fabricating functional multi-layer vocal fold models using an alternative approach, termed embedded 3D printing, that is a hybrid of casting and 3D printing. In this paper the fabrication process is described. Analysis of the resulting geometric and stiffness characteristics of the layers, including layer elastic modulus values ranging from less than 1 kPa to approximately 40 kPa, is presented. The results of tests demonstrating that the models are capable of sustained phonomimetic vibration are given. Capabilities and limitations of the embedded 3D printing process are discussed. It is concluded that the process has the potential to contribute to voice biomechanics research by facilitating prospective improvements in the fabrication, design, and functionality of multi-layer vocal fold models.
A comprehensive approach for the validation of lumbar spine finite element models investigating post-fusion adjacent segment effects.
Venue: Journal of biomechanics

Spinal fusion surgery is usually followed by accelerated degenerative changes in the unfused segments above and below the treated segment(s), i.e., adjacent segment disease (ASD). While a number of risk factors for ASD have been suggested, its exact pathogenesis remains to be identified. Finite element (FE) models are indispensable tools to investigate mechanical effects of fusion surgeries on post-fusion changes in the adjacent segment kinematics and kinetics. Existing modeling studies validate only their intact FE model against in vitro data and subsequently simulate post-fusion in vivo conditions. The present study provides a novel approach for the comprehensive validation of a lumbar (T12-S1) FE model in post-fusion conditions. Sixteen simulated fusion surgeries, performed on cadaveric specimens using various testing and loading conditions, were modeled by this FE model. Predictions for adjacent segment range of motion (RoM) and intradiscal pressure (IDP) were compared with those obtained from the corresponding in vitro tests. Overall, 70% of the predicted adjacent segment RoMs were within the range of in vitro data for both intact and post-fusion conditions. Correlation (r) values between model and in vitro findings for the adjacent segment RoMs were positive and greater than 0.84. Most of the predicted IDPs were, however, out of the narrow range of in vitro IDPs at the adjacent segments but with great positive correlations (r ≥ 0.89). FE modeling studies investigating the effect of fusion surgery on in vivo adjacent segment biomechanics are encouraged to use post-surgery in vitro data to validate their FE model.
In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.
Venue: Journal of biomechanics

Reliable and quantitative assessment of corneal biomechanics is important for the detection and treatment of corneal disease. The present study evaluates the repeatability and reproducibility of a novel optical coherence tomography (OCT)-based elastography (OCE) method for in vivo quantification of corneal natural frequency in 20 normal human eyes. Sub-micron corneal oscillations were induced by repeated low-force (13 Pa) microliter air pulses at the corneal apex and were observed by common-path phase-sensitive OCT imaging adjacent to a measurement region of 1-6.25 mm2. Corneal natural frequencies were quantified using a single degree of freedom model based on the corneal oscillations. Corneal natural frequencies ranged from 234 to 277 Hz (coefficient of variation: 3.2%; n = 286 for a 2.5 × 2.5 mm2 area; time: 28.6 s). The same natural frequencies can be acquired using a smaller sampling size (n = 9 for 1 mm2) and a shorter time (0.9 s). Spatial distribution and local changes in natural frequencies can be distinguished using denser sampling (e.g., 26 × 41 points for 2.5 × 5 mm2). This novel optical method demonstrates highly repeatable and reliable in vivo measurements of human corneal natural frequencies. While further studies are required to fully characterize anatomical and structural dependencies, this method may be complementary to the current OCE methods used to estimate Young's modulus from strain- or shear-wave-based measurements for the quantitative determination of corneal biomechanics.
Cyclic mechanical stimulation inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation via cell cycle arrest.
Venue: Journal of biomechanics

The imbalance between proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) has been the main cause of rheumatoid arthritis (RA) synovial hyperplasia. Our previous study confirmed that the cyclic mechanical stimulation (CMS) inhibited the proliferation of RA FLSs, but the underlying mechanisms are still unclear. This study aimed to investigate these underlying mechanisms. The in vitro cultured human RA FLSs were subjected to CMS (6%, 1.0 Hz). Cell cycle was detected by flow cytometry. The expression of cyclin D1, cyclin E1, CDK-2 and p27 was detected by reverse transcription-polymerase chain reaction (RT-PCR). MTS assay was used to detect cell viability. Cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) levels in RA FLSs were detected by western blotting and enzyme-linked immunosorbent assay (ELISA), respectively. The results showed that CMS significantly inhibited the cell cycle transformation of RA FLSs from G1 phase to S phase, which significantly decreased the cell proliferation index. Meanwhile, both cyclin E1 and CDK-2 gene expressions were significantly decreased, p27 gene expression was increased, and no significant change was observed in the expression of cyclin D1. The inhibition of COX-2/PGE2 pathway in RA FLSs by celecoxib treatment showed no effect on the inhibition of RA FLSs proliferation by CMS. In conclusion, CMS inhibited the proliferation of RA FLSs by modulating the expression of cell cycle-related molecules such as cyclin E1, CDK2 and p27 to arrest cell cycle transformation, which is independent of COX-2/PGE2 signaling pathway.