nils-herrmann/clean_scirepeval huggingface dataset:
Shape model constrained scaling improves repeatability of gait data.
Venue: Journal of biomechanics

Decisions made by gait researchers in the generation of kinematic or musculoskeletal models are a potential source of variation between researchers, leading to variable model outcomes. Statistical shape models can accurately predict bone geometry and have the potential to improve the repeatability of clinical gait analysis. The purpose of this study was to determine if using a shape model to scale segment length and joint centre locations would improve repeatability of kinematic and kinetic gait data, compared to linear scaling methods. Five participants completed a motion capture experiment, including a standing static trial and walking at a self-selected speed. Anatomical landmarks from the static trial were used by five experienced researchers to generate kinematic models using two methods; (1) linear scaling in OpenSim, and (2) shape-model scaling using our 'MAP Client' scale tool. The resulting models were used to perform an inverse kinematic and inverse dynamic analysis on the walking trials, and variation between researchers was analysed by comparing outputs from the same motion capture trial using different models. Higher variability between researchers was observed in joint angles (P < 0.001), joint moments (P < 0.005), and joint powers (P < 0.005) when using linear scaling, compared to shape-model scaling. Variation was at least three times as large for linearly-scaled models compared to shape-model scaled models. We have identified that linear scaling can lead to substantial variability in gait data across researchers, even with the same experimental data. Using a shape model to scale musculoskeletal models results in repeatable kinematic and kinetic gait data.
Explicit finite element analysis can predict the mechanical response of conical implant press-fit in homogenized trabecular bone.
Venue: Journal of biomechanics

Prediction of primary stability is a major challenge in the surgical planning of dental and orthopedic implants. Computational methods become attractive to estimate primary stability from clinical CT images, but implicit finite element analysis of implant press-fit faces convergence issues due to contact and highly distorted elements. This study aims to develop and validate an explicit finite element method to simulate the insertion and primary stability of a rigid implant in a deformable bone while accounting for damage occurring at the bone-implant interface. Accordingly, a press-fit experiment of a conical implant into predrilled bovine trabecular bone was designed and realized for six samples. A displacement-driven cyclic protocol was used to quantify the reaction force and stiffness of the bone-implant system. Homogenized finite element analyses of the experiments were performed by modeling contact with friction and converting an existing constitutive model with elasto-plasticity and damage of bone tissue to be applicable to an explicit time integration scheme where highly distorted elements get deleted. The computed reaction forces and unloading stiffnesses showed high correlations (R2 = 0.95 and R2 = 0.94) with the experiment. Friction between bone and implant exhibited a strong influence on both reaction force and stiffness. In conclusion, the developed explicit finite element approach with frictional contact and element deletion accounts properly for bone damage during press-fit and will help optimizing dental or orthopedic implant design towards maximal primary stability.
Using accelerations of single inertial measurement units to determine the intensity level of light-moderate-vigorous physical activities: Technical and mathematical considerations.
Venue: Journal of biomechanics

Quantifying physical activity and estimating the metabolic equivalent of tasks based on inertial measurement units has led to the emergence of multiple methods and data reduction approaches known as physical activity metrics. The present study aims to compare those metrics and reduction approaches based on descriptive and high order statistics. Data were obtained from 147 young healthy subjects wearing inertial measurement units at their wrist or ankle during standing, walking and running, labeled as light, medium or vigorous activities. The research question was, first, if those metrics allowed differentiating between light, moderate, and vigorous physical activities, and, secondly, what was the relationship with the metabolic equivalent of the task performed. The results showed that each metric differentiated the level of activity and presented a high correlation with the metabolic equivalent of the task. However, each metric and data reduction approach demonstrated its specific statistical characteristics related to the localization of the sensors. Our findings also confirm the absolute necessity to detail explicitly all calculus and post processing of metrics in order to quantify the level of activity by inertial measurement units.
Immature bovine cartilage wear by fatigue failure and delamination.
Venue: Journal of biomechanics

This study investigated wear damage of immature bovine articular cartilage using reciprocal sliding of tibial cartilage strips against glass or cartilage. Experiments were conducted in physiological buffered saline (PBS) or mature bovine synovial fluid (SF). A total of 63 samples were tested, of which 47 exhibited wear damage due to delamination of the cartilage surface initiated in the middle zone, with no evidence of abrasive wear. There was no difference between the friction coefficient of damaged and undamaged samples, showing that delamination wear occurs even when friction remains low under a migrating contact area configuration. No difference was observed in the onset of damage or in the friction coefficient between samples tested in PBS or SF. The onset of damage occurred earlier when testing cartilage against glass versus cartilage against cartilage, supporting the hypothesis that delamination occurs due to fatigue failure of the collagen in the middle zone, since stiffer glass produces higher strains and tensile stresses under comparable loads. The findings of this study are novel because they establish that delamination of the articular surface, starting in the middle zone, may represent a primary mechanism of failure. Based on preliminary data, it is reasonable to hypothesize that delamination wear via subsurface fatigue failure is similarly the primary mechanism of human cartilage wear under normal loading conditions, albeit requiring far more cycles of loading than in immature bovine cartilage.
Increase of stiffness in plantar fat tissue in diabetic patients.
Venue: Journal of biomechanics

Plantar soft tissue stiffening in diabetes leads to a risk of developing ulcers. There are relatively few studies providing methods for quantifying the mechanical properties of skin and fat in the plantar tissue of diabetic patients. Previous studies used linear or non-linear single layer deformable models or linear multi-layer models. This study aimed to investigate the mechanical properties of plantar soft tissue using multi-layer, non-linear models to estimate more accurate mechanical properties in the plantar tissues of diabetic patients. Ten healthy young (HY) subjects, ten healthy old (HO) subjects, and ten old diabetic patients (DB) volunteered for the study. Indentation tests were performed at two sites in the heel. The subjects underwent computed tomography (CT) to measure the respective thicknesses of the skin and fat at the indentation sites. Subject-specific finite element models were created to estimate the parameters of the first-order Ogden forms of the skin and fat. The initial shear modulus for the fat layer μF in DB, HO, and HY were 4.68 MPa (±0.87), 2.71 MPa (±1.25), and 2.27 MPa (±0.87), respectively. The initial shear modulus for the skin layer (μS) in DB, HO, and HY were 5.86 MPa (±2.51), 7.05 MPa (±1.94), and 14.58 MPa (±1.98), respectively. The DB had stiffer fat tissue than the normal subjects in the same age group but had the same soft skin. These aspects can cause different mechanical stress conditions in a diabetic foot than in a normal foot under the same mechanical loading, making the diabetic foot vulnerable to the initiation of mechanical breakdowns such as ulcers.
Sex-based differences in landing mechanics vary between the drop vertical jump and stop jump.
Venue: Journal of biomechanics

The purpose of the present study was to compare landing mechanics between the stop jump (SJ) and drop vertical jump (DVJ) and to compare sex-based differences in landing mechanics between tasks. 50 healthy recreational athletes were recruited and each participant completed seven SJs and seven DVJs. Peak knee flexion and abduction angle, knee flexion and ab/adduction range of motion (ROM), peak vertical and posterior ground reaction force (GRF), peak internal knee extension and knee adduction moment were computed for the dominant limb during the first landing of both tasks. A two-way ANOVA was used to determine the effects of and interactions between sex (men vs women) and task (SJ vs DVJ) for each outcome. There was an interaction for peak vertical GRF (p = 0.024), knee flexion ROM (p = 0.027), knee ab/adduction ROM (p = 0.047), and peak knee flexion (p = 0.034) and adduction (p = 0.012) moment. The SJ resulted in smaller vertical GRFs, larger posterior GRFs, and larger peak internal knee adduction moments relative to the DVJ (all p < 0.002). Women landed with larger peak knee abduction angles, larger internal knee adduction moments, and smaller knee extension moments relative to men (p = 0.001-0.026). Overall, as the SJ resulted in larger posterior GRFs and internal knee adduction moments, this task produced movements which resemble most anterior cruciate ligament (ACL) injuries and are risk factors for ACL injuries. As the SJ produced more sex-based differences, it may be better suited than the DVJ for ACL injury risk screening. This study therefore stressed the importance of selecting an appropriate landing task for ACL injury prevention research and clinical return to sport assessment.
Asymmetric in-plane shear behavior of isolated cadaveric lumbar facet capsular ligaments: Implications for subject specific biomechanical models.
Venue: Journal of biomechanics

The facet capsular ligaments (FCLs) flank the spinous process on the posterior aspect of the spine. The lumbar FCL is collagenous, with collagen fibers aligned primarily bone-to-bone (medial-lateral) and experiences significant shear, especially during spinal flexion and extension. We characterized the mechanical response of the lumbar FCL to in-plane shear, and we evaluated that response in the context of the fiber architecture. In-plane shear tests with both positive and negative shear (i.e., corresponding to flexion and to extension) were performed on eight cadaveric human L4-L5 FCLs. Our most striking observation was subject-dependent asymmetry in the response. All samples showed a toe region of low stiffness, transitioning to greater stiffness at higher strains, for both shear directions. Different samples showed profoundly different transition strains, with some samples stiffening more rapidly in positive shear and some in negative shear. This unpredictable asymmetry, which did not correlate with age, side, or degeneration state, suggesting that collagen fibers in the FCL are sometimes aligned at a slight positive angle from the bone-to-bone axis and sometimes at a negative angle. Fitting the experimental data to a fiber-composite-based finite element model supported this idea, yielding optimal fits with positive or negative off-axis fiber directions (-40° to +40°). Subsequent examination of selected FCLs by small-angle x-ray scattering (SAXS) showed a similar variability in fiber direction. We conclude that small individual differences in lumbar FCL architecture may have a significant effect on lumbar FCL mechanics, especially at moderate strains.
Comparison study of bone strength of the proximal femur with and without hip osteoarthritis by computed tomography-based finite element analysis.
Venue: Journal of biomechanics

Proximal femoral fractures are common in elderly osteoporosis patients; however, its prevalence is clinically rare in hip fracture patients with hip osteoarthritis (OA). This study aimed to evaluate bone strength of the proximal femur with or without hip OA and proximal femoral fracture risk using computed tomography (CT)-based finite element analysis (FEA). A retrospective analysis was done on CT data of 20 patients who underwent total hip arthroplasty for unilateral hip OA. Furthermore, the fracture load between OA and contralateral sides was compared and the association between fracture load and risk factor was analyzed. The fracture load was significantly higher in the OA side than that in the contralateral side (3819.5 ± 1557.8 N vs. 3224.5 ± 943.7 N, respectively; P = 0.0405). There was no significant difference in fracture load between OA and the contralateral side in Kellgren-Lawrence (KL)-3 and KL-4 grade, but the KL-4 fracture load tends to be high (P = 0.2461 and P = 0.0527, respectively). Moreover, there was no significant association between fracture load and OA severity or age. The study findings may assist in predicting bone strength and proximal femur fracture risk. The results of this FEA study indicate the bone strength of the proximal femur was affected by the severity of the osteoarthritis.
Effect of rotator cuff muscle activation on glenohumeral kinematics: A cadaveric study.
Venue: Journal of biomechanics

Healthy shoulder function requires the coordination of the rotator cuff muscles to maintain the humeral head's position in the glenoid. While glenohumeral stability has been studied in various settings, few studies have characterized the effect of dynamic rotator cuff muscle loading on glenohumeral translation during shoulder motion. We hypothesize that dynamic rotator cuff muscle activation decreases joint translation during continuous passive abduction of the humerus in a cadaveric model of scapular plane glenohumeral abduction. The effect of different rotator cuff muscle activity on glenohumeral translation was assessed using a validated shoulder testing system. The Dynamic Load profile is a novel approach, based on musculoskeletal modeling of human subject motion. Passive humeral elevation in the scapular plane was applied via the testing system arm, while the rotator cuff muscles were activated according to the specified force profiles using stepper motors and a proportional control feedback loop. Glenohumeral translation was defined according to the International Society of Biomechanics. The Dynamic load profile minimized superior translation of the humeral head relative to the conventional loading profiles. The total magnitude of translation was not significantly different (0.805) among the loading profiles suggesting that the compressive forces from the rotator cuff primarily alter the direction of humeral head translation, not the magnitude. Rotator cuff muscle loading is an important element of cadaveric shoulder studies that must be considered to accurately simulate glenohumeral motion. A rotator cuff muscle activity profile based on human subject muscle activity reduces superior glenohumeral translation when compared to previous RC loading profiles.
Worn region size of shoe outsole impacts human slips: Testing a mechanistic model.
Venue: Journal of biomechanics

Shoe outsole tread wear has been shown to increase slip risk by reducing the tread's ability to channel fluid away from the shoe-floor interface. This study establishes a connection between geometric features of the worn region size and slipping. A mechanistic pathway that describes the relationship between the worn region size and slip risk is assessed. Specifically, it is hypothesized that an increased worn region size leads to an increase in under-shoe fluid pressure, which reduces friction, and subsequently increases slipping. The worn region size, fluid pressure, and slip outcome were recorded for 57 participants, who were exposed to an unexpected slip condition. Shoes were collected from each participant and the available coefficient of friction (ACOF) was measured using a tribometer. A greater shoe worn region size was associated with increased slip occurrence. Specifically, a 1 mm increase in the characteristic length of the worn region (geometric mean of its width and length) was associated with an increase in slip risk of ~10%. Fluid pressure and ACOF results supported the mechanistic model: an increase in worn region size correlated with an increase in peak fluid pressure; peak fluid pressures negatively correlated with ACOF; and increased ACOF correlated with decreased slip risk. This finding supports the use of worn region size as a metric to assess the risk of slipping.
Prediction of post-stenting biomechanics in coarcted aortas: A pilot finite element study.
Venue: Journal of biomechanics

Endovascular stenting has recently become a standard treatment for native coarctation of the aorta (CoA) in children and young adults, given the efficacy in relieving vessel obstruction with a low incidence of adverse events. Yet, despite the short-term success of the technique, late hypertension remains an endemic risk. To assess the impact of the percutaneous procedure on the aortic wall biomechanics, we designed a novel finite element (FE) protocol for the simulation of endovascular stenting in three patient-specific CoA anatomies, developing a remeshing procedure that allows for coping with different CoA severities. Our FE protocol was able to yield numerical results on stent distortions and stresses, as well as on changes in aortic wall stresses and distensibility. These results were consistent with intraprocedural in-vivo evidences and with previous findings from the literature, and they suggest that our numerical approach could be used to understand the role of patient specific anatomical features (CoA severity and arch type) on the post-stenting aortic biomechanics. If soundly validated on a vast cohort of patients, our approach could support patient selection for the procedure.
Biomechanical evaluation of a new passive back support exoskeleton.
Venue: Journal of biomechanics

The number one cause of disability in the world is low-back pain, with mechanical loading as one of the major risk factors. To reduce mechanical loading, exoskeletons have been introduced in the workplace. Substantial reductions in back muscle activity were found when using the exoskeleton during static bending and manual materials handling. However, most exoskeletons only have one joint at hip level, resulting in loss of range of motion and shifting of the exoskeleton relative to the body. To address these issues, a new exoskeleton design has been developed and tested. The present study investigated the effect of the SPEXOR passive exoskeleton on compression forces, moments, muscle activity and kinematics during static bending at six hand heights and during lifting of a box of 10 kg from around ankle height using three techniques: Free, Squat and Stoop. For static bending, the exoskeleton reduced the compression force by 13-21% depending on bending angle. Another effect of the exoskeleton was that participants substantially reduced lumbar flexion. While lifting, the exoskeleton reduced the peak compression force, on average, by 14%. Lifting technique did not modify the effect of the exoskeleton such that the reduction in compression force was similar. In conclusion, substantial reductions in compression forces were found as a result of the support generated by the exoskeleton and changes in behavior when wearing the exoskeleton. For static bending, lumbar flexion was reduced with the exoskeleton, indicating reduced passive tissue strain. In addition, the reduced peak compression force could reduce the risk of compression induced tissue failure during lifting.
Explaining Parkinsonian postural sway variabilities using intermittent control theory.
Venue: Journal of biomechanics

Postural impairment due to neuro-degenerative disorders such as Parkinson's Disease (PD) leads to restricted gait patterns, fall-related injuries, decreased mobility, and loss of functional independence. Though several clinical and posturographic studies have attempted to reveal the complex pathophysiology involved in PD, the diversity of Parkinsonian population makes them unclear and sometimes even contradictory. For instance, studies related to the Center of Pressure (CoP) sway during quiet stance in PD patients highlight both increase and reduction of magnitude in contrast to age-matched healthy individuals. A possible explanation for this contradiction is presented in this article. While the presence of intermittent control has been observed in postural control in human quiet stance, we hypothesize that one of the factors that affects postural instability in PD might be the increase in intermittency in active feedback control. Using a simulation model representing the Anterior-Posterior dynamics of human quiet standing, the intermittent control strategy is first contrasted against continuous control strategy in terms of stability, energy efficiency and settling time, thus establishing the inherent advantages of an intermittent control strategy. Further, the ability of the intermittent control strategy to explain several clinical observations in PD is demonstrated. An experimental pilot study is also conducted to support the simulation study, and several body sway parameters derived from recordings of CoP are presented. The presented results are in close agreement with reported clinical observations and may also prove useful for the assessment of disease progression and future fall risk.
New insights into lumbar flexion tests based on inverse and direct kinematic musculoskeletal modeling.
Venue: Journal of biomechanics

Measurement of maximal lumbar flexion is considered to be a crucial element in the assessment of lumbar spine mechanics in situations as diverse as physiotherapy, orthopaedics, ergonomics, sport or aging. However, currently, there is no consensus on a reference test. This study aims to characterise five maximal lumbar flexion tests (four classical tests and a new, specifically-developed test designed to constrain pelvic retroversion) based on a three-dimensional, participant-specific musculoskeletal model. Twenty-six male and female participants performed the five tests. Movements were modelled in OpenSim to estimate change in length in lumbar, hamstring and gluteus muscles, together with lumbar flexion and pelvic tilt. These so-called "inverse" kinematic results were compared using a two-way ANOVA (sex×test). In a second step, lumbar muscle change in length was computed using a direct kinematic method. Lumbar flexion and lumbar muscle change in length were found to be greater when participants were in seated postures, with little pelvic retroversion. Female participants were observed to have less lumbar flexion than male participants (77±14° and 91±12°, respectively). Hip extensor muscles (hamstrings and gluteus) were fully stretched during each of the five tests. Our results highlight the specific roles of hamstrings, gluteus and lumbar muscles into reaching maximal lumbar flexion. Coupling inverse and direct kinematic methods proved to be a useful tool to enhance our knowledge of lumbar tests. Our findings help to characterise the role of the muscles involved in lumbar flexion, and we propose some recommendations for improving and standardising these tests.