Algunos de los clientes de Akamai son Adobe Systems Incorporated, E*TRADE, American Express, Yahoo!, AOL Radio, Symantec, Match.com, Google, Microsoft, FedEx, BBC News web, la Canadian Broadcasting Corporation, Xerox, iVillage, Apple, Facebook, Music Television (MTV), los United States Geological Survey, la Casa Blanca, Reuters, Newegg.com, y XM Radio.