Las grandes estrellas invitadas aparecidas en "Pete y Pete" incluían a Sam Rockwell, Selma Blair, Steve Buscemi, LL Cool J, Chris Elliott, Janeane Garofalo, Frank Gifford, Debbie Harry, Patty Hearst, David Johansen (Buster Poindexter), Luscious Jackson, John McLaughlin, Iggy Pop, Michael Stipe, Liza Weil, William Hickey, Kate Pierson y Adam West.