Lejos de QOTSA, Homme ha colaborado con un sinfín de bandas y músicos como Screaming Trees, Mondo Generator, Foo Fighters, PJ Harvey, Fatso Jetson, Mark Lanegan Band, Trent Reznor, Masters of Reality, Millionaire, Wellwater Conspiracy, U.N.K.L.E., Melissa Auf Der Maur, Paz Lenchantin, A Perfect Circle, Death from Above 1979, Earthlings?, Mastodon, Peaches, Eagles of Death Metal y Local H.