Otros grandes nombres de la música que ya actuaron en la MEO Arena fueron: Hardwell, 30 Seconds To Mars, 50 Cent, Blink-182, Alicia Keys, Anahí Puente, Anastacia, Andrea Bocelli, Ariana Grande, Anselmo Ralph, Backstreet Boys, Bauhaus, Britney Spears, Ben Harper, Mariza, Ivete Sangalo, Beyoncé, The Black Keys, Bruno Mars, Bryan Adams, Busta Rhymes, Charles Aznavour, Carlos Santana, Chris Brown, Coldplay, Carly Rae Jepsen, Dave Matthews Band, Depeche Mode, Diante do Trono, Eagles, Enrique Iglesias, Eric Clapton, Eurovistion 2018, Elton John, Eros Ramazzotti, George Michael, Godsmack, Limp Bizkit, Guns N' Roses, Il Divo, Incubus, Iron Maiden, Jack Johnson, Jamiroquai, Joaquín Cortés, Jessie J, Joe Cocker, Judas Priest, Julio Iglesias, Justin Bieber, Korn, Jennifer Lopez, Justin Timberlake, Katy Perry, Kylie Minogue, Lenny Kravitz, Leonard Cohen, Limp Bizkit, Linkin Park, Lady Gaga, LMFAO, Madonna, Massive Attack, Michael Bublé , Marilyn Manson, Mark Knopfler, Mastodon, Megadeth, Metallica, Miley Cyrus, Moby, Muse, Oasis, One Direction, Pearl Jam, Plácido Domingo, Rammstein, Red Hot Chili Peppers, Ricky Martin, Rihanna, Robbie Williams, Roger Waters, Scorpions, Shakira, Semi Precious Weapons, Selena Gomez, Sigur Rós, Soy Luna Live, Simply Red, Slayer, Slipknot, Supertramp, Testament, The Black Eyed Peas, The Cranberries, The Cure, The Offspring, The Prodigy, The Pussycat Dolls, The Script, The Who, Tokio Hotel, Tool, UB40, Violetta, Luan Santana, K-Pop, Dreamcather, y tantos otros.