Repository: DavAug/ErlotinibGefitinib

Issue:
Create optimisation function that makes notebooks better readable

Discussion:

Patch:
diff --git a/notebooks/lung_cancer/control_growth/identifiability_structural_model.ipynb b/notebooks/lung_cancer/control_growth/identifiability_structural_model.ipynb
index 8cfed81..e4a2ac1 100644
--- a/notebooks/lung_cancer/control_growth/identifiability_structural_model.ipynb
+++ b/notebooks/lung_cancer/control_growth/identifiability_structural_model.ipynb
@@ -2053,20 +2053,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"f06b5209-902e-4da8-a835-ddab923800f4\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"4f1ade24-e53f-4a9d-99d2-64310a031ba9\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"f06b5209-902e-4da8-a835-ddab923800f4\")) {\n",
+       "                if (document.getElementById(\"4f1ade24-e53f-4a9d-99d2-64310a031ba9\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        'f06b5209-902e-4da8-a835-ddab923800f4',\n",
+       "                        '4f1ade24-e53f-4a9d-99d2-64310a031ba9',\n",
        "                        [{\"hovertemplate\": \"<b>ID: 40</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 40\", \"showlegend\": true, \"text\": [\"26.8 g\", \"26.1 g\", \"26.5 g\", \"26.5 g\", \"27.1 g\", \"26.0 g\", \"26.4 g\", \"26.0 g\", \"25.4 g\", \"26.2 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [0.191808, 0.249158, 0.330672, 0.6683669999999999, 0.915008, 1.119258, 1.470432, 1.6692479999999998, 1.7521919999999997, 2.276736]}, {\"hovertemplate\": \"<b>ID: 40</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 40\", \"showlegend\": true, \"text\": [\"26.8 g\", \"26.1 g\", \"26.5 g\", \"26.5 g\", \"27.1 g\", \"26.0 g\", \"26.4 g\", \"26.0 g\", \"25.4 g\", \"26.2 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [26.8, 26.1, 26.5, 26.5, 27.1, 26.0, 26.4, 26.0, 25.4, 26.2]}, {\"hovertemplate\": \"<b>ID: 94</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 94\", \"showlegend\": true, \"text\": [\"18.3 g\", \"18.2 g\", \"18.5 g\", \"18.3 g\", \"18.7 g\", \"17.9 g\", \"18.4 g\", \"18.2 g\", \"18.7 g\", \"20.0 g\", \"20.2 g\", \"20.3 g\", \"20.0 g\", \"19.2 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.07724750000000001, 0.0884835, 0.125316, 0.165528, 0.189486, 0.264654, 0.264654, 0.306936, 0.389207, 0.389207, 0.405769, 0.4264715, 0.5551309999999999, 0.57624]}, {\"hovertemplate\": \"<b>ID: 94</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 94\", \"showlegend\": true, \"text\": [\"18.3 g\", \"18.2 g\", \"18.5 g\", \"18.3 g\", \"18.7 g\", \"17.9 g\", \"18.4 g\", \"18.2 g\", \"18.7 g\", \"20.0 g\", \"20.2 g\", \"20.3 g\", \"20.0 g\", \"19.2 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [18.3, 18.2, 18.5, 18.3, 18.7, 17.9, 18.4, 18.2, 18.7, 20.0, 20.2, 20.3, 20.0, 19.2]}, {\"hovertemplate\": \"<b>ID: 95</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 95\", \"showlegend\": true, \"text\": [\"22.3 g\", \"23.0 g\", \"22.4 g\", \"23.6 g\", \"24.1 g\", \"22.7 g\", \"23.6 g\", \"23.3 g\", \"23.3 g\", \"23.3 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [0.1862, 0.24641999999999997, 0.4293, 0.62426, 0.7246720000000001, 0.7300800000000001, 0.9196, 1.131184, 1.675872, 2.346616]}, {\"hovertemplate\": \"<b>ID: 95</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 95\", \"showlegend\": true, \"text\": [\"22.3 g\", \"23.0 g\", \"22.4 g\", \"23.6 g\", \"24.1 g\", \"22.7 g\", \"23.6 g\", \"23.3 g\", \"23.3 g\", \"23.3 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [22.3, 23.0, 22.4, 23.6, 24.1, 22.7, 23.6, 23.3, 23.3, 23.3]}, {\"hovertemplate\": \"<b>ID: 136</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 136\", \"showlegend\": true, \"text\": [\"25.4 g\", \"26.2 g\", \"28.3 g\", \"28.0 g\", \"25.1 g\", \"22.9 g\", \"24.1 g\", \"23.9 g\", \"23.0 g\", \"24.0 g\", \"23.7 g\", \"24.7 g\", \"24.6 g\", \"24.2 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.1185885, 0.175071, 0.22999200000000006, 0.3026885, 0.3026885, 0.37044, 0.5341545, 0.651688, 0.7212869999999999, 0.78732, 0.8529505000000001, 1.104558, 1.1328799999999999, 1.4593425]}, {\"hovertemplate\": \"<b>ID: 136</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 136\", \"showlegend\": true, \"text\": [\"25.4 g\", \"26.2 g\", \"28.3 g\", \"28.0 g\", \"25.1 g\", \"22.9 g\", \"24.1 g\", \"23.9 g\", \"23.0 g\", \"24.0 g\", \"23.7 g\", \"24.7 g\", \"24.6 g\", \"24.2 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [25.4, 26.2, 28.3, 28.0, 25.1, 22.9, 24.1, 23.9, 23.0, 24.0, 23.7, 24.7, 24.6, 24.2]}, {\"hovertemplate\": \"<b>ID: 140</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#FFA15A\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 140\", \"showlegend\": true, \"text\": [\"22.7 g\", \"23.6 g\", \"23.6 g\", \"24.4 g\", \"25.0 g\", \"23.5 g\", \"24.8 g\", \"24.3 g\", \"23.8 g\", \"23.3 g\", \"23.7 g\", \"24.8 g\", \"24.7 g\", \"24.1 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.0793305, 0.12685200000000002, 0.146072, 0.261121, 0.34574400000000005, 0.3552, 0.41905, 0.48029799999999995, 0.556668, 0.8089919999999999, 0.8573040000000001, 1.097675, 1.992144, 2.1225820000000004]}, {\"hovertemplate\": \"<b>ID: 140</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#FFA15A\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 140\", \"showlegend\": true, \"text\": [\"22.7 g\", \"23.6 g\", \"23.6 g\", \"24.4 g\", \"25.0 g\", \"23.5 g\", \"24.8 g\", \"24.3 g\", \"23.8 g\", \"23.3 g\", \"23.7 g\", \"24.8 g\", \"24.7 g\", \"24.1 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [22.7, 23.6, 23.6, 24.4, 25.0, 23.5, 24.8, 24.3, 23.8, 23.3, 23.7, 24.8, 24.7, 24.1]}, {\"hovertemplate\": \"<b>ID: 155</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#19D3F3\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 155\", \"showlegend\": true, \"text\": [\"26.0 g\", \"27.3 g\", \"27.5 g\", \"28.2 g\", \"28.7 g\", \"27.9 g\", \"28.6 g\", \"29.0 g\", \"28.0 g\", \"28.9 g\", \"28.5 g\", \"29.6 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25], \"y\": [0.105875, 0.167706, 0.35632800000000003, 0.6489600000000001, 0.692224, 0.7300800000000001, 0.81648, 1.4949540000000001, 1.5166985, 1.72405, 1.637784, 2.25108]}, {\"hovertemplate\": \"<b>ID: 155</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#19D3F3\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 155\", \"showlegend\": true, \"text\": [\"26.0 g\", \"27.3 g\", \"27.5 g\", \"28.2 g\", \"28.7 g\", \"27.9 g\", \"28.6 g\", \"29.0 g\", \"28.0 g\", \"28.9 g\", \"28.5 g\", \"29.6 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25], \"y\": [26.0, 27.3, 27.5, 28.2, 28.7, 27.9, 28.6, 29.0, 28.0, 28.9, 28.5, 29.6]}, {\"hovertemplate\": \"<b>ID: 169</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#FF6692\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 169\", \"showlegend\": true, \"text\": [\"26.9 g\", \"26.8 g\", \"26.2 g\", \"26.2 g\", \"27.3 g\", \"26.6 g\", \"28.0 g\", \"27.6 g\", \"26.6 g\", \"27.9 g\", \"27.4 g\", \"28.6 g\", \"27.5 g\", \"28.0 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.123008, 0.128774, 0.1764, 0.20516650000000006, 0.24605349999999998, 0.2788425, 0.333036, 0.35644499999999996, 0.39285, 0.479859, 0.5390550000000001, 0.6354195, 0.7146180000000001, 0.7469865]}, {\"hovertemplate\": \"<b>ID: 169</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#FF6692\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 169\", \"showlegend\": true, \"text\": [\"26.9 g\", \"26.8 g\", \"26.2 g\", \"26.2 g\", \"27.3 g\", \"26.6 g\", \"28.0 g\", \"27.6 g\", \"26.6 g\", \"27.9 g\", \"27.4 g\", \"28.6 g\", \"27.5 g\", \"28.0 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [26.9, 26.8, 26.2, 26.2, 27.3, 26.6, 28.0, 27.6, 26.6, 27.9, 27.4, 28.6, 27.5, 28.0]}, {\"hovertemplate\": \"<b>ID: 170</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#B6E880\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 170\", \"showlegend\": true, \"text\": [\"28.3 g\", \"27.7 g\", \"27.9 g\", \"28.8 g\", \"29.3 g\", \"28.6 g\", \"29.5 g\", \"28.9 g\", \"26.8 g\", \"28.7 g\", \"27.3 g\", \"28.7 g\", \"28.5 g\", \"27.5 g\"], \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.0800565, 0.094221, 0.10933, 0.158994, 0.17615699999999998, 0.19407850000000001, 0.2041605, 0.246402, 0.3050865, 0.3683265, 0.41817600000000005, 0.4396155, 0.5661554999999999, 0.6206265000000001]}, {\"hovertemplate\": \"<b>ID: 170</b><br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Body weight: %{text}<br>Cancer type: Lung cancer (LXF A677)<br><extra></extra>\", \"marker\": {\"color\": \"#B6E880\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 170\", \"showlegend\": true, \"text\": [\"28.3 g\", \"27.7 g\", \"27.9 g\", \"28.8 g\", \"29.3 g\", \"28.6 g\", \"29.5 g\", \"28.9 g\", \"26.8 g\", \"28.7 g\", \"27.3 g\", \"28.7 g\", \"28.5 g\", \"27.5 g\"], \"type\": \"scatter\", \"visible\": false, \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [28.3, 27.7, 27.9, 28.8, 29.3, 28.6, 29.5, 28.9, 26.8, 28.7, 27.3, 28.7, 28.5, 27.5]}],\n",
        "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"yaxis.type\": \"linear\"}], \"label\": \"Linear y-scale\", \"method\": \"relayout\"}, {\"args\": [{\"yaxis.type\": \"log\"}], \"label\": \"Log y-scale\", \"method\": \"relayout\"}], \"direction\": \"left\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.15, \"yanchor\": \"top\"}, {\"buttons\": [{\"args\": [{\"visible\": [true, false, true, false, true, false, true, false, true, false, true, false, true, false, true, false]}, {\"yaxis\": {\"title\": \"$\\\\text{Tumour volume in cm}^3$\"}}], \"label\": \"Tumour volume\", \"method\": \"update\"}, {\"args\": [{\"visible\": [false, true, false, true, false, true, false, true, false, true, false, true, false, true, false, true]}, {\"yaxis\": {\"title\": \"$\\\\text{Body weight in g}$\"}}], \"label\": \"Body weight\", \"method\": \"update\"}], \"direction\": \"down\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 1.07, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"xaxis\": {\"title\": {\"text\": \"$\\\\text{Time in day}$\"}}, \"yaxis\": {\"title\": {\"text\": \"$\\\\text{Tumour volume in cm}^3$\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('f06b5209-902e-4da8-a835-ddab923800f4');\n",
+       "var gd = document.getElementById('4f1ade24-e53f-4a9d-99d2-64310a031ba9');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -2151,6 +2151,13 @@
     "There are many algorithms that are designed to minimise an objective function. One of those algorithms is the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) optimiser [5]. We will choose to minimise the objective function $L$ with this algorithm, but other choices are equally valid. From a naïve perspective, we can choose any initial starting point $\\psi _0 $ for the optimisation algorithm, as the true global minimum is independent of the method we use to find it. We therefore choose to start the optimisation somewhat arbitrarily at $\\psi _0 = (1, 1, 1)$."
    ]
   },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Run optimisation"
+   ]
+  },
   {
    "cell_type": "code",
    "execution_count": 2,
@@ -2161,7 +2168,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "d51ab40e87f44e3e89463ba39fb762e1",
+       "model_id": "86be1ba9a8464a8e956a13ca918899ac",
        "version_major": 2,
        "version_minor": 0
       },
@@ -2203,17 +2210,15 @@
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - Eigenmann et. al.')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=False)\n",
     "\n",
-    "# Define container for estimates and scores\n",
+    "# Define initial parameters\n",
     "# Shape (n_mice, n_parameters)\n",
     "n_parameters = model.n_parameters()\n",
     "n_mice = len(data['#ID'].unique())\n",
-    "mouse_parameters = np.empty(shape=(n_mice, n_parameters))\n",
-    "mouse_scores = np.empty(shape=n_mice)\n",
+    "initial_parameters = [[1, 1, 1]]\n",
     "\n",
-    "# Define \"arbitrary\" starting point for the optimisations\n",
-    "initial_parameters = [1, 1, 1]\n",
-    "\n",
-    "# Find mouse parameters for LXF A677 population\n",
+    "# Find parameters for each mouse\n",
+    "mouse_parameters = []\n",
+    "mouse_scores = []\n",
     "mouse_ids = data['#ID'].unique()\n",
     "for index, mouse_id in enumerate(tqdm(mouse_ids)):\n",
     "    # Get data\n",
@@ -2224,21 +2229,19 @@
     "    # Define inverse problem\n",
     "    problem = pints.SingleOutputProblem(model, times, observed_volumes)\n",
     "    error = pints.SumOfSquaresError(problem)\n",
-    "\n",
-    "    # Set up optimiser\n",
-    "    optimiser = pints.OptimisationController(\n",
-    "        function=error,\n",
-    "        x0=initial_parameters,\n",
-    "        method=pints.CMAES)\n",
-    "    optimiser.set_log_to_screen(False)\n",
-    "    optimiser.set_parallel(True)\n",
-    "\n",
-    "    # Find optimal parameters\n",
-    "    estimates, score = optimiser.run()\n",
-    "\n",
-    "    # Save estimates and score\n",
-    "    mouse_parameters[index, :] = estimates\n",
-    "    mouse_scores[index] = score"
+    "    \n",
+    "    # Run optimisation\n",
+    "    p, s = pkpd.optimise(error, pints.CMAES, initial_parameters)\n",
+    "    mouse_parameters += [p[0, :]]\n",
+    "    mouse_scores += [p[0, :]]\n",
+    "\n"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Visualise results"
    ]
   },
   {
@@ -2357,56 +2360,56 @@
           30
          ],
          "y": [
-          0.13956418108483046,
-          0.17116600884478397,
-          0.20653244219621172,
-          0.24549907163169107,
-          0.28778173712282784,
-          0.3330942241831177,
-          0.3811551486070831,
-          0.4316859661415817,
-          0.4844415603477769,
-          0.5391645561347044,
-          0.5956714386915158,
-          0.6537379803506269,
-          0.7132321964280728,
-          0.7739846553105056,
-          0.8359081312907347,
-          0.8988674048252112,
-          0.9627699731720641,
-          1.0274973508016607,
-          1.0929862773580181,
-          1.1591818955931117,
-          1.226009488128883,
-          1.2934251300060609,
-          1.3613911823238551,
-          1.4298782602323856,
-          1.4988172325850895,
-          1.5681812043531425,
-          1.6379439121438752,
-          1.708091748770253,
-          1.778606743974769,
-          1.849474396288955,
-          1.9206374752525663,
-          1.9920863443618453,
-          2.0638036156057975,
-          2.135797648994886,
-          2.20805375303277,
-          2.2805544921431053,
-          2.353257063724285,
-          2.4261522948065064,
-          2.499238919454209,
-          2.572532569132624,
-          2.6460246765868534,
-          2.7196873329014957,
-          2.7934895781740856,
-          2.8674216595637363,
-          2.941506623419459,
-          3.015753990374507,
-          3.09016500468537,
-          3.164686930469697,
-          3.239309198883628,
-          3.3140155218849716
+          0.13968348916887086,
+          0.1713021138077012,
+          0.2066859206166381,
+          0.24567053640544528,
+          0.28797190763005653,
+          0.3333037053135794,
+          0.3813845597003298,
+          0.4319359314268276,
+          0.4847127878160087,
+          0.5394575503691392,
+          0.5959871090360708,
+          0.6540765387447833,
+          0.71359465045401,
+          0.7743708333986667,
+          0.8363191361501382,
+          0.8993033099198733,
+          0.963231528622957,
+          1.0279852775075882,
+          1.0934999873029683,
+          1.1597221137496094,
+          1.2265766155869422,
+          1.2940191365981604,
+          1.362012166138088,
+          1.4305261992040725,
+          1.499493242496382,
+          1.5688852507743942,
+          1.6386762884839265,
+          1.7088524964277418,
+          1.77939587038866,
+          1.850292229113272,
+          1.921484377376191,
+          1.9929626719549398,
+          2.0647094431275366,
+          2.136732943374237,
+          2.209018403732395,
+          2.281548829924916,
+          2.354281401325436,
+          2.4272070243704365,
+          2.500323886843149,
+          2.5736476757491964,
+          2.6471696809891956,
+          2.7208627258749276,
+          2.7946956474752094,
+          2.8686588969732334,
+          2.94277459158648,
+          3.017052568139717,
+          3.091493787161383,
+          3.166046731914561,
+          3.2407002801411946,
+          3.315438302164288
          ]
         },
         {
@@ -2521,56 +2524,56 @@
           30
          ],
          "y": [
-          0.0750689595774453,
-          0.08201872745376036,
-          0.0892228121524108,
-          0.09667503737578698,
-          0.10435990527278677,
-          0.11226409733872462,
-          0.1203758485910905,
-          0.12868187049802507,
-          0.1371690754458942,
-          0.14582421038316662,
-          0.15464209655171032,
-          0.16360987589781223,
-          0.17271880349673205,
-          0.18196044918786,
-          0.19132581694443912,
-          0.2008124210308056,
-          0.21041276157382527,
-          0.22011694572391688,
-          0.2299164258848737,
-          0.239802654460489,
-          0.24977278748854773,
-          0.25982566411106883,
-          0.26995263065888014,
-          0.28015168705653937,
-          0.29042063664789247,
-          0.3007540481732209,
-          0.31114956363837226,
-          0.321604257103168,
-          0.33211426246767767,
-          0.34267807129289873,
-          0.3532930902263818,
-          0.36395616768583766,
-          0.37466611704723074,
-          0.3854205343807459,
-          0.3962169036209223,
-          0.40705476598679075,
-          0.4179319767805983,
-          0.4288466198799942,
-          0.43979692607442494,
-          0.45078145244171675,
-          0.4617996045851682,
-          0.47284943127762646,
-          0.48392957923040547,
-          0.4950387469348456,
-          0.5061761335775085,
-          0.5173407873765825,
-          0.5285315758398785,
-          0.5397476028121071,
-          0.5509880281485471,
-          0.5622513306106651
+          0.07530398604608193,
+          0.08222528791697552,
+          0.089400910552185,
+          0.09682485458364076,
+          0.10448256553990083,
+          0.11235995238025903,
+          0.12044577471143254,
+          0.1287270077037804,
+          0.13719124551430603,
+          0.14582381473354203,
+          0.15462146472242846,
+          0.1635692786940999,
+          0.17266030823607054,
+          0.18188555987058658,
+          0.19123606180869585,
+          0.20070979755415327,
+          0.21029876552647414,
+          0.21999318729766712,
+          0.2297845203942871,
+          0.2396642223428889,
+          0.24962791978580695,
+          0.2596764344591822,
+          0.26980047297825066,
+          0.2799969793464917,
+          0.29026504086363125,
+          0.30059882110838154,
+          0.31099543447421457,
+          0.32145258089902917,
+          0.33196619431988583,
+          0.34253413761890783,
+          0.3531545878810134,
+          0.3638241369414788,
+          0.37454104487971795,
+          0.3853035920534815,
+          0.39610903029934863,
+          0.40695622544781235,
+          0.4178438641219169,
+          0.42876974226068815,
+          0.43973208792568036,
+          0.45072914244354456,
+          0.4617606130773183,
+          0.4728244719651606,
+          0.4839193288181445,
+          0.4950438662794898,
+          0.5061970206487633,
+          0.5173781270424416,
+          0.5285859176872771,
+          0.5398194712703738,
+          0.5510779397160338,
+          0.5623600432224457
          ]
         },
         {
@@ -2615,7 +2618,7 @@
          ]
         },
         {
-         "hovertemplate": "<b>Simulation </b><br>ID: 95<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.00 cm^3<br>Expon. growth rate: -94.99 1/day<br>Lin. growth rate: 0.09 cm^3/day<br><extra></extra>",
+         "hovertemplate": "<b>Simulation </b><br>ID: 95<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.22 cm^3<br>Expon. growth rate: 0.06 1/day<br>Lin. growth rate: 756205776436.28 cm^3/day<br><extra></extra>",
          "legendgroup": "ID: 95",
          "line": {
           "color": "#00CC96"
@@ -2677,56 +2680,56 @@
           30
          ],
          "y": [
-          0.003435516477769125,
-          0.05879722644195681,
-          0.1131518846766705,
-          0.16738819261243587,
-          0.22156894838134428,
-          0.2757029214429862,
-          0.3298122055250737,
-          0.3838956063096826,
-          0.437957243959117,
-          0.4919970811805628,
-          0.5460188768471123,
-          0.6000272120870097,
-          0.6540230128790706,
-          0.7080099667404929,
-          0.7619944777365378,
-          0.8159783410984183,
-          0.8699652037937216,
-          0.923960589875388,
-          0.9779675743554087,
-          1.0319900473187043,
-          1.0860288778012186,
-          1.1400888673552463,
-          1.1941738364767431,
-          1.248287448698048,
-          1.3024333675514985,
-          1.3566039609953862,
-          1.4108003505382576,
-          1.4650292041019788,
-          1.519292622614311,
-          1.5735927070030162,
-          1.6278975639653142,
-          1.682127649116383,
-          1.736297445474162,
-          1.7904019961517617,
-          1.8445202945411114,
-          1.8986135652253744,
-          1.9526834083062141,
-          2.0067484312853154,
-          2.0608068136798696,
-          2.114863318224327,
-          2.1689146580676533,
-          2.2229648029674376,
-          2.277017480372565,
-          2.331069790828096,
-          2.385121257918914,
-          2.4391745500301227,
-          2.493228139654394,
-          2.547279787113753,
-          2.6013310893795216,
-          2.655382181384316
+          0.2210876623511744,
+          0.236670303601348,
+          0.25332619228008374,
+          0.27115182240038904,
+          0.29023057162747407,
+          0.31065350086853816,
+          0.33251608267689536,
+          0.35591938352513486,
+          0.3809679710921989,
+          0.40778482443321573,
+          0.43648413058095537,
+          0.4672078857108866,
+          0.5000905216460154,
+          0.5352887308029428,
+          0.5729653031720112,
+          0.6132887686698211,
+          0.6564588544292062,
+          0.7026593868602096,
+          0.7521180625949911,
+          0.8050533115690113,
+          0.8617148881406886,
+          0.9223679176776022,
+          0.9872813737416133,
+          1.0567768062870813,
+          1.1311515448815266,
+          1.2107699836449564,
+          1.2959867443009407,
+          1.3871998603535256,
+          1.48484132240592,
+          1.589340283484256,
+          1.7012143008811647,
+          1.8209446249155778,
+          1.9491140292289253,
+          2.0862986249358344,
+          2.233132226115674,
+          2.390319127665788,
+          2.558543707686258,
+          2.7386387819090046,
+          2.931383787789195,
+          3.1377101179329103,
+          3.35855430332557,
+          3.594924729545583,
+          3.847970305262478,
+          4.118781853656844,
+          4.40869910332753,
+          4.718985249331035,
+          5.0511277958997765,
+          5.4066501305898615,
+          5.787155113342906,
+          6.194518002725285
          ]
         },
         {
@@ -2841,56 +2844,56 @@
           30
          ],
          "y": [
-          0.1490325593636432,
-          0.15808091850289402,
-          0.16759402596075315,
-          0.17760466930496918,
-          0.18813326425195112,
-          0.1991991644581372,
-          0.21081558196443068,
-          0.22300015700338569,
-          0.23577083433016274,
-          0.24914391572962816,
-          0.2631369859028454,
-          0.27776516364427445,
-          0.2930433188527294,
-          0.30898887391531804,
-          0.32561542304840024,
-          0.34293147007843733,
-          0.3609550065971965,
-          0.37969925024956797,
-          0.3991653834830708,
-          0.41937042642151773,
-          0.44032610128803584,
-          0.4620294929776745,
-          0.4844926511479885,
-          0.5077251348806997,
-          0.5317247108778375,
-          0.5564939829310411,
-          0.5820413138739164,
-          0.6083652323633388,
-          0.6354598351935689,
-          0.6633317190340944,
-          0.6919780413438327,
-          0.7213784911963828,
-          0.7515397765706958,
-          0.7824595510475981,
-          0.814135746362608,
-          0.8465665724059359,
-          0.8797505172224845,
-          0.9136714167243527,
-          0.9483154252486214,
-          0.9836827037060196,
-          1.0197647746789573,
-          1.0565524144767084,
-          1.0940333234474668,
-          1.1321974492609848,
-          1.1710328844539055,
-          1.21052694044636,
-          1.2506707576162142,
-          1.2914563917636337,
-          1.332868141028896,
-          1.374893178279298
+          0.1489261709396449,
+          0.1579724344976988,
+          0.16748357656959442,
+          0.17749239035583936,
+          0.18801930770474395,
+          0.19908367441833577,
+          0.21069874507891198,
+          0.22288213577621274,
+          0.2356518464625913,
+          0.24902416081329326,
+          0.26301668584941224,
+          0.2776445332394774,
+          0.2929226077890455,
+          0.3088683386224854,
+          0.32549527065008155,
+          0.3428119899577106,
+          0.3608364758767259,
+          0.3795818728139921,
+          0.39904946089987,
+          0.41925624350690127,
+          0.4402139519770716,
+          0.4619194761136211,
+          0.48438514165685265,
+          0.5076204179546976,
+          0.5316228565119956,
+          0.5563953448942008,
+          0.5819461544993533,
+          0.6082735997651081,
+          0.6353720379236856,
+          0.6632479842120895,
+          0.6918983431941538,
+          0.7213033913116794,
+          0.7514696441482791,
+          0.7823947665415927,
+          0.8140766888933925,
+          0.8465136071695835,
+          0.8797039829002026,
+          0.9136291688548364,
+          0.948278989151663,
+          0.9836520873024414,
+          1.0197399531688447,
+          1.056533160104125,
+          1.0940195543939095,
+          1.1321889860995005,
+          1.1710295093471232,
+          1.2105283979417254,
+          1.2506778996725196,
+          1.2914684398102296,
+          1.332884883787669,
+          1.3749143688373249
          ]
         },
         {
@@ -2943,7 +2946,7 @@
          ]
         },
         {
-         "hovertemplate": "<b>Simulation </b><br>ID: 140<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.11 cm^3<br>Expon. growth rate: 0.05 1/day<br>Lin. growth rate: -0.62 cm^3/day<br><extra></extra>",
+         "hovertemplate": "<b>Simulation </b><br>ID: 140<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.00 cm^3<br>Expon. growth rate: -5.89 1/day<br>Lin. growth rate: 0.05 cm^3/day<br><extra></extra>",
          "legendgroup": "ID: 140",
          "line": {
           "color": "#FFA15A"
@@ -3005,56 +3008,56 @@
           30
          ],
          "y": [
-          0.10916880136317669,
-          0.11548211447923,
-          0.12215466763192728,
-          0.12921996140290726,
-          0.13670098713716677,
-          0.1446242750721689,
-          0.15301796742923535,
-          0.16191185403173688,
-          0.17133575459063316,
-          0.18132442008664787,
-          0.1919110286383354,
-          0.2031360208029102,
-          0.21503719231391621,
-          0.22766116841805903,
-          0.2410512973661536,
-          0.2552613330614718,
-          0.2703411369337453,
-          0.28635290790462153,
-          0.3033541736551296,
-          0.3214172513868626,
-          0.34060877599248623,
-          0.3610132794315106,
-          0.38270837883418896,
-          0.4057936467809747,
-          0.43035976702920736,
-          0.4565241162208413,
-          0.4843936860516606,
-          0.5141089913000476,
-          0.5457969248507628,
-          0.5796266039388496,
-          0.6157500011457633,
-          0.6543728795222106,
-          0.6956790725490618,
-          0.739922121169242,
-          0.787327087068026,
-          0.8382110610940094,
-          0.8928535807394149,
-          0.9516583195667286,
-          1.0149528802278625,
-          1.0832317709365182,
-          1.1570311694463882,
-          1.2369582567626365,
-          1.3237164191246378,
-          1.4181349405518022,
-          1.5212051627860135,
-          1.634124616458287,
-          1.758286884072661,
-          1.895454809165915,
-          2.047816993649765,
-          2.218161665964989
+          0.0042137209214960485,
+          0.04381414312778873,
+          0.07598843282818003,
+          0.10732352877276732,
+          0.13826510918019466,
+          0.16901280665644683,
+          0.19963325033565474,
+          0.23013463746066648,
+          0.26053879582952755,
+          0.2908781278600614,
+          0.32116117982472897,
+          0.3513992012963601,
+          0.3815985835322687,
+          0.4117695761363211,
+          0.44191441083513117,
+          0.47203728615206875,
+          0.5021378602872361,
+          0.5322178999855297,
+          0.5622816428374509,
+          0.5923291808631274,
+          0.6223621091569475,
+          0.6523856341307996,
+          0.6824009298667245,
+          0.7124101359478013,
+          0.7424165054839637,
+          0.7724231536741206,
+          0.8024322903416767,
+          0.8324461543486963,
+          0.8624657813305121,
+          0.8924945577738864,
+          0.9225349849074114,
+          0.9525895639596784,
+          0.9826607961592798,
+          1.0127416757087533,
+          1.042835882918851,
+          1.0729469840751489,
+          1.1030764768707675,
+          1.1332258589988278,
+          1.1633895006659771,
+          1.1935528230839514,
+          1.223726625761042,
+          1.253910355684912,
+          1.2841034598432255,
+          1.3143053852236457,
+          1.3445088704072305,
+          1.374715291069105,
+          1.4049242880693775,
+          1.4351346820089368,
+          1.4653452934886713,
+          1.4955526908123833
          ]
         },
         {
@@ -3165,56 +3168,56 @@
           30
          ],
          "y": [
-          0.13289508506007228,
-          0.15586907496921498,
-          0.1811891198790772,
-          0.20882034452502357,
-          0.23868349761505117,
-          0.2706757111925021,
-          0.3046833666442406,
-          0.34058372737496084,
-          0.378251227775322,
-          0.41756808742961443,
-          0.4584245734184706,
-          0.5006972329856638,
-          0.5442789568408719,
-          0.5890673371806849,
-          0.6349677081813065,
-          0.6818839578184717,
-          0.7297492240068137,
-          0.7784741147278148,
-          0.8280183306702931,
-          0.8783029956447845,
-          0.9292872809334285,
-          0.9809074193412858,
-          1.0331067599813488,
-          1.085866169207287,
-          1.1391389717582137,
-          1.192887583034637,
-          1.2470853722864934,
-          1.3017078366326031,
-          1.3567325012600033,
-          1.4121314075415008,
-          1.4678735703752361,
-          1.5239447968269646,
-          1.580328081376956,
-          1.6370103178625515,
-          1.6939788175197137,
-          1.7512216416691453,
-          1.8087045557868506,
-          1.8664279931966927,
-          1.9243841408225484,
-          1.9825676510790908,
-          2.04097564187179,
-          2.0995705045837374,
-          2.158347265803658,
-          2.2173105866241083,
-          2.276456817068782,
-          2.335783822278843,
-          2.395277430675571,
-          2.4549069914412973,
-          2.5146852445956727,
-          2.574607139645615
+          0.13289521677814017,
+          0.15586920871402227,
+          0.18118925396967,
+          0.20882047740573442,
+          0.23868362791706255,
+          0.2706758377485569,
+          0.3046834885102385,
+          0.3405838438248227,
+          0.3782513382850754,
+          0.41756819152723196,
+          0.4584246708596359,
+          0.5006973237948031,
+          0.5442790410872245,
+          0.5890674149399729,
+          0.6349677798519743,
+          0.6818840234493424,
+          0.7297492841515331,
+          0.7784741694172376,
+          0.8280183804028716,
+          0.8783030406571601,
+          0.9292873216792555,
+          0.9809074563461092,
+          1.0331067938492249,
+          1.0858661994971082,
+          1.1391389992764758,
+          1.1928876081401072,
+          1.2470853950810485,
+          1.3017078574129268,
+          1.3567325201775484,
+          1.4121314253346946,
+          1.4678735871115358,
+          1.5239448127518067,
+          1.580328096643315,
+          1.6370103326334062,
+          1.6939788318921623,
+          1.7512216563364982,
+          1.8087045707404845,
+          1.866428008542508,
+          1.9243841566008606,
+          1.982567667258475,
+          2.0409756583429273,
+          2.0995705233258866,
+          2.1583472857540658,
+          2.2173106078061418,
+          2.276456839455631,
+          2.335783845789713,
+          2.395277456885177,
+          2.4549070196536986,
+          2.514685274918651,
+          2.5746071721699417
          ]
         },
         {
@@ -3329,56 +3332,56 @@
           30
          ],
          "y": [
-          0.12380953918621371,
-          0.12963233527269766,
-          0.1356776599726892,
-          0.14196427019523752,
-          0.14849887863967873,
-          0.15528834482739334,
-          0.16234414556070403,
-          0.1696665581123434,
-          0.17725809589848696,
-          0.18513265274801055,
-          0.19328913133556835,
-          0.20173196618451555,
-          0.21047098025528618,
-          0.21950916324634148,
-          0.2288517064623708,
-          0.23850338722848138,
-          0.2484694906135205,
-          0.25875486356966615,
-          0.2693573858166189,
-          0.28028514409211525,
-          0.29154279772713554,
-          0.3031350060526601,
-          0.3150664283996691,
-          0.3273325198653623,
-          0.3399333729037933,
-          0.3528775907201086,
-          0.3661684385704767,
-          0.3798091817110659,
-          0.3938023099944159,
-          0.408139372974878,
-          0.4228266965402446,
-          0.4378653922150704,
-          0.45325286831341266,
-          0.4689872008619439,
-          0.48507000293112396,
-          0.5015008832197367,
-          0.5182752310056652,
-          0.5353940521581922,
-          0.5528564353406947,
-          0.5706590988812881,
-          0.588799141024859,
-          0.6072759843117127,
-          0.6260876975565114,
-          0.6452286405754784,
-          0.6646980911426703,
-          0.6844936506471199,
-          0.7046107720758864,
-          0.7250452305102179,
-          0.7457949711480385,
-          0.766856904457612
+          0.1233297930696544,
+          0.12917400904675988,
+          0.13524240697791065,
+          0.14155374353960912,
+          0.14811464101739308,
+          0.15493194582729886,
+          0.16201658121824938,
+          0.1693688536738379,
+          0.176992422656531,
+          0.18489914137655375,
+          0.1930887146082162,
+          0.20156648820532647,
+          0.21034075868023452,
+          0.21941496418732415,
+          0.22879406890233944,
+          0.23848281074659186,
+          0.24848635900032645,
+          0.258807141441921,
+          0.26944670986386376,
+          0.28041167953452695,
+          0.29170658292664337,
+          0.3033359525129458,
+          0.3152996664311165,
+          0.32759353249554196,
+          0.340226806872561,
+          0.35320268111674563,
+          0.36652434678266804,
+          0.38019074829383587,
+          0.3941917874060112,
+          0.40853744948066195,
+          0.42322923742683677,
+          0.43826865415358385,
+          0.45365489272456616,
+          0.46937629082333426,
+          0.4854408061711596,
+          0.5018485028549898,
+          0.5185994449617725,
+          0.5356929480717494,
+          0.5531184676192257,
+          0.5708815551328771,
+          0.5889818970632519,
+          0.6074027426501095,
+          0.6261526950313202,
+          0.645231754206884,
+          0.6646230290412768,
+          0.6843342378170659,
+          0.7043658486600162,
+          0.7246936223832026,
+          0.7453246793920194,
+          0.7662597980987639
          ]
         },
         {
@@ -3493,56 +3496,56 @@
           30
          ],
          "y": [
-          0.08704780721650865,
-          0.09087058932405861,
-          0.09484611537101284,
-          0.09898888431356445,
-          0.10330566975552591,
-          0.10780297160289032,
-          0.11248790636081003,
-          0.11736795441014584,
-          0.12245057781409108,
-          0.1277440406740812,
-          0.1332553356456488,
-          0.13899223210299305,
-          0.14496475150925317,
-          0.15117978807808483,
-          0.15764534770450636,
-          0.1643729895847364,
-          0.17137001467893034,
-          0.17864509450373434,
-          0.1862098704418804,
-          0.19407328469310842,
-          0.2022443992890991,
-          0.210735300484366,
-          0.2195568508236995,
-          0.22871853666926434,
-          0.2382306359883087,
-          0.24810342907864352,
-          0.25834897239885823,
-          0.2689807259038682,
-          0.2800080639276013,
-          0.2914423142684007,
-          0.30329490442525253,
-          0.3155775103750429,
-          0.32830327670392934,
-          0.34148343300400913,
-          0.35513012307555814,
-          0.3692556236930693,
-          0.3838723446052522,
-          0.398990934556032,
-          0.41462415977521655,
-          0.43078466740265536,
-          0.44748491776774896,
-          0.46473745725463983,
-          0.48255251328355403,
-          0.5009408273105285,
-          0.5199157152947695,
-          0.539489081712422,
-          0.5596728182307846,
-          0.5804745621512226,
-          0.6018942542011583,
-          0.6239525195140858
+          0.0870275375518596,
+          0.09084972926671613,
+          0.09482465244458126,
+          0.0989668045108156,
+          0.10328295827323132,
+          0.10777961353435146,
+          0.112463886573618,
+          0.1173432572032446,
+          0.1224251875171039,
+          0.12771794037200498,
+          0.1332285081655138,
+          0.1389646609526948,
+          0.14493641782024883,
+          0.15115067302872498,
+          0.15761543336910186,
+          0.16434225508896153,
+          0.17133843913311117,
+          0.17861265626950276,
+          0.18617654937539152,
+          0.19403905567887608,
+          0.20220923783088274,
+          0.21069918555119863,
+          0.21951975537469556,
+          0.22868043379765435,
+          0.2381914972690412,
+          0.24806322439640457,
+          0.2583076625475848,
+          0.2689382848671039,
+          0.2799644564045343,
+          0.29139750266033276,
+          0.303248848637231,
+          0.3155301617480711,
+          0.32825459283454717,
+          0.341433364529537,
+          0.35507861726365925,
+          0.3692026242369256,
+          0.3838177914187406,
+          0.3989347796524953,
+          0.4145663230198504,
+          0.43072507578582064,
+          0.44742349331525305,
+          0.4646741167724575,
+          0.48248721365614217,
+          0.5008734479647304,
+          0.5198461585439019,
+          0.5394172433419175,
+          0.5595985871555587,
+          0.5803980724210378,
+          0.6018154101543338,
+          0.6238712474264247
          ]
         }
        ],
@@ -4404,20 +4407,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"927fb346-b2e1-4e32-84ce-fc768cca5c4f\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"13d018dc-4ebb-4a6a-84fc-cfe99eb353ce\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"927fb346-b2e1-4e32-84ce-fc768cca5c4f\")) {\n",
+       "                if (document.getElementById(\"13d018dc-4ebb-4a6a-84fc-cfe99eb353ce\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        '927fb346-b2e1-4e32-84ce-fc768cca5c4f',\n",
-       "                        [{\"hovertemplate\": \"<b>Measurement </b><br>ID: 40<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 40\", \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 40\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [0.191808, 0.249158, 0.330672, 0.6683669999999999, 0.915008, 1.119258, 1.470432, 1.6692479999999998, 1.7521919999999997, 2.276736]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 40<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.14 cm^3<br>Expon. growth rate: 0.27 1/day<br>Lin. growth rate: 0.13 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 40\", \"line\": {\"color\": \"#636EFA\"}, \"mode\": \"lines\", \"name\": \"ID: 40\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.13956418108483046, 0.17116600884478397, 0.20653244219621172, 0.24549907163169107, 0.28778173712282784, 0.3330942241831177, 0.3811551486070831, 0.4316859661415817, 0.4844415603477769, 0.5391645561347044, 0.5956714386915158, 0.6537379803506269, 0.7132321964280728, 0.7739846553105056, 0.8359081312907347, 0.8988674048252112, 0.9627699731720641, 1.0274973508016607, 1.0929862773580181, 1.1591818955931117, 1.226009488128883, 1.2934251300060609, 1.3613911823238551, 1.4298782602323856, 1.4988172325850895, 1.5681812043531425, 1.6379439121438752, 1.708091748770253, 1.778606743974769, 1.849474396288955, 1.9206374752525663, 1.9920863443618453, 2.0638036156057975, 2.135797648994886, 2.20805375303277, 2.2805544921431053, 2.353257063724285, 2.4261522948065064, 2.499238919454209, 2.572532569132624, 2.6460246765868534, 2.7196873329014957, 2.7934895781740856, 2.8674216595637363, 2.941506623419459, 3.015753990374507, 3.09016500468537, 3.164686930469697, 3.239309198883628, 3.3140155218849716]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 94<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 94\", \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 94\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.07724750000000001, 0.0884835, 0.125316, 0.165528, 0.189486, 0.264654, 0.264654, 0.306936, 0.389207, 0.389207, 0.405769, 0.4264715, 0.5551309999999999, 0.57624]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 94<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.08 cm^3<br>Expon. growth rate: 0.16 1/day<br>Lin. growth rate: 0.02 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 94\", \"line\": {\"color\": \"#EF553B\"}, \"mode\": \"lines\", \"name\": \"ID: 94\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.0750689595774453, 0.08201872745376036, 0.0892228121524108, 0.09667503737578698, 0.10435990527278677, 0.11226409733872462, 0.1203758485910905, 0.12868187049802507, 0.1371690754458942, 0.14582421038316662, 0.15464209655171032, 0.16360987589781223, 0.17271880349673205, 0.18196044918786, 0.19132581694443912, 0.2008124210308056, 0.21041276157382527, 0.22011694572391688, 0.2299164258848737, 0.239802654460489, 0.24977278748854773, 0.25982566411106883, 0.26995263065888014, 0.28015168705653937, 0.29042063664789247, 0.3007540481732209, 0.31114956363837226, 0.321604257103168, 0.33211426246767767, 0.34267807129289873, 0.3532930902263818, 0.36395616768583766, 0.37466611704723074, 0.3854205343807459, 0.3962169036209223, 0.40705476598679075, 0.4179319767805983, 0.4288466198799942, 0.43979692607442494, 0.45078145244171675, 0.4617996045851682, 0.47284943127762646, 0.48392957923040547, 0.4950387469348456, 0.5061761335775085, 0.5173407873765825, 0.5285315758398785, 0.5397476028121071, 0.5509880281485471, 0.5622513306106651]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 95<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 95\", \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 95\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [0.1862, 0.24641999999999997, 0.4293, 0.62426, 0.7246720000000001, 0.7300800000000001, 0.9196, 1.131184, 1.675872, 2.346616]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 95<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.00 cm^3<br>Expon. growth rate: -94.99 1/day<br>Lin. growth rate: 0.09 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 95\", \"line\": {\"color\": \"#00CC96\"}, \"mode\": \"lines\", \"name\": \"ID: 95\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.003435516477769125, 0.05879722644195681, 0.1131518846766705, 0.16738819261243587, 0.22156894838134428, 0.2757029214429862, 0.3298122055250737, 0.3838956063096826, 0.437957243959117, 0.4919970811805628, 0.5460188768471123, 0.6000272120870097, 0.6540230128790706, 0.7080099667404929, 0.7619944777365378, 0.8159783410984183, 0.8699652037937216, 0.923960589875388, 0.9779675743554087, 1.0319900473187043, 1.0860288778012186, 1.1400888673552463, 1.1941738364767431, 1.248287448698048, 1.3024333675514985, 1.3566039609953862, 1.4108003505382576, 1.4650292041019788, 1.519292622614311, 1.5735927070030162, 1.6278975639653142, 1.682127649116383, 1.736297445474162, 1.7904019961517617, 1.8445202945411114, 1.8986135652253744, 1.9526834083062141, 2.0067484312853154, 2.0608068136798696, 2.114863318224327, 2.1689146580676533, 2.2229648029674376, 2.277017480372565, 2.331069790828096, 2.385121257918914, 2.4391745500301227, 2.493228139654394, 2.547279787113753, 2.6013310893795216, 2.655382181384316]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 136<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 136\", \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 136\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.1185885, 0.175071, 0.22999200000000006, 0.3026885, 0.3026885, 0.37044, 0.5341545, 0.651688, 0.7212869999999999, 0.78732, 0.8529505000000001, 1.104558, 1.1328799999999999, 1.4593425]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 136<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.15 cm^3<br>Expon. growth rate: 0.05 1/day<br>Lin. growth rate: 0.13 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 136\", \"line\": {\"color\": \"#AB63FA\"}, \"mode\": \"lines\", \"name\": \"ID: 136\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.1490325593636432, 0.15808091850289402, 0.16759402596075315, 0.17760466930496918, 0.18813326425195112, 0.1991991644581372, 0.21081558196443068, 0.22300015700338569, 0.23577083433016274, 0.24914391572962816, 0.2631369859028454, 0.27776516364427445, 0.2930433188527294, 0.30898887391531804, 0.32561542304840024, 0.34293147007843733, 0.3609550065971965, 0.37969925024956797, 0.3991653834830708, 0.41937042642151773, 0.44032610128803584, 0.4620294929776745, 0.4844926511479885, 0.5077251348806997, 0.5317247108778375, 0.5564939829310411, 0.5820413138739164, 0.6083652323633388, 0.6354598351935689, 0.6633317190340944, 0.6919780413438327, 0.7213784911963828, 0.7515397765706958, 0.7824595510475981, 0.814135746362608, 0.8465665724059359, 0.8797505172224845, 0.9136714167243527, 0.9483154252486214, 0.9836827037060196, 1.0197647746789573, 1.0565524144767084, 1.0940333234474668, 1.1321974492609848, 1.1710328844539055, 1.21052694044636, 1.2506707576162142, 1.2914563917636337, 1.332868141028896, 1.374893178279298]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 140<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 140\", \"marker\": {\"color\": \"#FFA15A\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 140\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.0793305, 0.12685200000000002, 0.146072, 0.261121, 0.34574400000000005, 0.3552, 0.41905, 0.48029799999999995, 0.556668, 0.8089919999999999, 0.8573040000000001, 1.097675, 1.992144, 2.1225820000000004]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 140<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.11 cm^3<br>Expon. growth rate: 0.05 1/day<br>Lin. growth rate: -0.62 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 140\", \"line\": {\"color\": \"#FFA15A\"}, \"mode\": \"lines\", \"name\": \"ID: 140\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.10916880136317669, 0.11548211447923, 0.12215466763192728, 0.12921996140290726, 0.13670098713716677, 0.1446242750721689, 0.15301796742923535, 0.16191185403173688, 0.17133575459063316, 0.18132442008664787, 0.1919110286383354, 0.2031360208029102, 0.21503719231391621, 0.22766116841805903, 0.2410512973661536, 0.2552613330614718, 0.2703411369337453, 0.28635290790462153, 0.3033541736551296, 0.3214172513868626, 0.34060877599248623, 0.3610132794315106, 0.38270837883418896, 0.4057936467809747, 0.43035976702920736, 0.4565241162208413, 0.4843936860516606, 0.5141089913000476, 0.5457969248507628, 0.5796266039388496, 0.6157500011457633, 0.6543728795222106, 0.6956790725490618, 0.739922121169242, 0.787327087068026, 0.8382110610940094, 0.8928535807394149, 0.9516583195667286, 1.0149528802278625, 1.0832317709365182, 1.1570311694463882, 1.2369582567626365, 1.3237164191246378, 1.4181349405518022, 1.5212051627860135, 1.634124616458287, 1.758286884072661, 1.895454809165915, 2.047816993649765, 2.218161665964989]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 155<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 155\", \"marker\": {\"color\": \"#19D3F3\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 155\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25], \"y\": [0.105875, 0.167706, 0.35632800000000003, 0.6489600000000001, 0.692224, 0.7300800000000001, 0.81648, 1.4949540000000001, 1.5166985, 1.72405, 1.637784, 2.25108]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 155<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.13 cm^3<br>Expon. growth rate: 0.20 1/day<br>Lin. growth rate: 0.11 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 155\", \"line\": {\"color\": \"#19D3F3\"}, \"mode\": \"lines\", \"name\": \"ID: 155\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.13289508506007228, 0.15586907496921498, 0.1811891198790772, 0.20882034452502357, 0.23868349761505117, 0.2706757111925021, 0.3046833666442406, 0.34058372737496084, 0.378251227775322, 0.41756808742961443, 0.4584245734184706, 0.5006972329856638, 0.5442789568408719, 0.5890673371806849, 0.6349677081813065, 0.6818839578184717, 0.7297492240068137, 0.7784741147278148, 0.8280183306702931, 0.8783029956447845, 0.9292872809334285, 0.9809074193412858, 1.0331067599813488, 1.085866169207287, 1.1391389717582137, 1.192887583034637, 1.2470853722864934, 1.3017078366326031, 1.3567325012600033, 1.4121314075415008, 1.4678735703752361, 1.5239447968269646, 1.580328081376956, 1.6370103178625515, 1.6939788175197137, 1.7512216416691453, 1.8087045557868506, 1.8664279931966927, 1.9243841408225484, 1.9825676510790908, 2.04097564187179, 2.0995705045837374, 2.158347265803658, 2.2173105866241083, 2.276456817068782, 2.335783822278843, 2.395277430675571, 2.4549069914412973, 2.5146852445956727, 2.574607139645615]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 169<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 169\", \"marker\": {\"color\": \"#FF6692\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 169\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.123008, 0.128774, 0.1764, 0.20516650000000006, 0.24605349999999998, 0.2788425, 0.333036, 0.35644499999999996, 0.39285, 0.479859, 0.5390550000000001, 0.6354195, 0.7146180000000001, 0.7469865]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 169<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.12 cm^3<br>Expon. growth rate: 0.04 1/day<br>Lin. growth rate: 0.07 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 169\", \"line\": {\"color\": \"#FF6692\"}, \"mode\": \"lines\", \"name\": \"ID: 169\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.12380953918621371, 0.12963233527269766, 0.1356776599726892, 0.14196427019523752, 0.14849887863967873, 0.15528834482739334, 0.16234414556070403, 0.1696665581123434, 0.17725809589848696, 0.18513265274801055, 0.19328913133556835, 0.20173196618451555, 0.21047098025528618, 0.21950916324634148, 0.2288517064623708, 0.23850338722848138, 0.2484694906135205, 0.25875486356966615, 0.2693573858166189, 0.28028514409211525, 0.29154279772713554, 0.3031350060526601, 0.3150664283996691, 0.3273325198653623, 0.3399333729037933, 0.3528775907201086, 0.3661684385704767, 0.3798091817110659, 0.3938023099944159, 0.408139372974878, 0.4228266965402446, 0.4378653922150704, 0.45325286831341266, 0.4689872008619439, 0.48507000293112396, 0.5015008832197367, 0.5182752310056652, 0.5353940521581922, 0.5528564353406947, 0.5706590988812881, 0.588799141024859, 0.6072759843117127, 0.6260876975565114, 0.6452286405754784, 0.6646980911426703, 0.6844936506471199, 0.7046107720758864, 0.7250452305102179, 0.7457949711480385, 0.766856904457612]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 170<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 170\", \"marker\": {\"color\": \"#B6E880\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 170\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.0800565, 0.094221, 0.10933, 0.158994, 0.17615699999999998, 0.19407850000000001, 0.2041605, 0.246402, 0.3050865, 0.3683265, 0.41817600000000005, 0.4396155, 0.5661554999999999, 0.6206265000000001]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 170<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.09 cm^3<br>Expon. growth rate: 0.04 1/day<br>Lin. growth rate: 0.19 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 170\", \"line\": {\"color\": \"#B6E880\"}, \"mode\": \"lines\", \"name\": \"ID: 170\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.08704780721650865, 0.09087058932405861, 0.09484611537101284, 0.09898888431356445, 0.10330566975552591, 0.10780297160289032, 0.11248790636081003, 0.11736795441014584, 0.12245057781409108, 0.1277440406740812, 0.1332553356456488, 0.13899223210299305, 0.14496475150925317, 0.15117978807808483, 0.15764534770450636, 0.1643729895847364, 0.17137001467893034, 0.17864509450373434, 0.1862098704418804, 0.19407328469310842, 0.2022443992890991, 0.210735300484366, 0.2195568508236995, 0.22871853666926434, 0.2382306359883087, 0.24810342907864352, 0.25834897239885823, 0.2689807259038682, 0.2800080639276013, 0.2914423142684007, 0.30329490442525253, 0.3155775103750429, 0.32830327670392934, 0.34148343300400913, 0.35513012307555814, 0.3692556236930693, 0.3838723446052522, 0.398990934556032, 0.41462415977521655, 0.43078466740265536, 0.44748491776774896, 0.46473745725463983, 0.48255251328355403, 0.5009408273105285, 0.5199157152947695, 0.539489081712422, 0.5596728182307846, 0.5804745621512226, 0.6018942542011583, 0.6239525195140858]}],\n",
+       "                        '13d018dc-4ebb-4a6a-84fc-cfe99eb353ce',\n",
+       "                        [{\"hovertemplate\": \"<b>Measurement </b><br>ID: 40<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 40\", \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 40\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [0.191808, 0.249158, 0.330672, 0.6683669999999999, 0.915008, 1.119258, 1.470432, 1.6692479999999998, 1.7521919999999997, 2.276736]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 40<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.14 cm^3<br>Expon. growth rate: 0.27 1/day<br>Lin. growth rate: 0.13 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 40\", \"line\": {\"color\": \"#636EFA\"}, \"mode\": \"lines\", \"name\": \"ID: 40\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.13968348916887086, 0.1713021138077012, 0.2066859206166381, 0.24567053640544528, 0.28797190763005653, 0.3333037053135794, 0.3813845597003298, 0.4319359314268276, 0.4847127878160087, 0.5394575503691392, 0.5959871090360708, 0.6540765387447833, 0.71359465045401, 0.7743708333986667, 0.8363191361501382, 0.8993033099198733, 0.963231528622957, 1.0279852775075882, 1.0934999873029683, 1.1597221137496094, 1.2265766155869422, 1.2940191365981604, 1.362012166138088, 1.4305261992040725, 1.499493242496382, 1.5688852507743942, 1.6386762884839265, 1.7088524964277418, 1.77939587038866, 1.850292229113272, 1.921484377376191, 1.9929626719549398, 2.0647094431275366, 2.136732943374237, 2.209018403732395, 2.281548829924916, 2.354281401325436, 2.4272070243704365, 2.500323886843149, 2.5736476757491964, 2.6471696809891956, 2.7208627258749276, 2.7946956474752094, 2.8686588969732334, 2.94277459158648, 3.017052568139717, 3.091493787161383, 3.166046731914561, 3.2407002801411946, 3.315438302164288]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 94<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 94\", \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 94\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.07724750000000001, 0.0884835, 0.125316, 0.165528, 0.189486, 0.264654, 0.264654, 0.306936, 0.389207, 0.389207, 0.405769, 0.4264715, 0.5551309999999999, 0.57624]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 94<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.08 cm^3<br>Expon. growth rate: 0.16 1/day<br>Lin. growth rate: 0.02 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 94\", \"line\": {\"color\": \"#EF553B\"}, \"mode\": \"lines\", \"name\": \"ID: 94\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.07530398604608193, 0.08222528791697552, 0.089400910552185, 0.09682485458364076, 0.10448256553990083, 0.11235995238025903, 0.12044577471143254, 0.1287270077037804, 0.13719124551430603, 0.14582381473354203, 0.15462146472242846, 0.1635692786940999, 0.17266030823607054, 0.18188555987058658, 0.19123606180869585, 0.20070979755415327, 0.21029876552647414, 0.21999318729766712, 0.2297845203942871, 0.2396642223428889, 0.24962791978580695, 0.2596764344591822, 0.26980047297825066, 0.2799969793464917, 0.29026504086363125, 0.30059882110838154, 0.31099543447421457, 0.32145258089902917, 0.33196619431988583, 0.34253413761890783, 0.3531545878810134, 0.3638241369414788, 0.37454104487971795, 0.3853035920534815, 0.39610903029934863, 0.40695622544781235, 0.4178438641219169, 0.42876974226068815, 0.43973208792568036, 0.45072914244354456, 0.4617606130773183, 0.4728244719651606, 0.4839193288181445, 0.4950438662794898, 0.5061970206487633, 0.5173781270424416, 0.5285859176872771, 0.5398194712703738, 0.5510779397160338, 0.5623600432224457]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 95<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 95\", \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 95\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21], \"y\": [0.1862, 0.24641999999999997, 0.4293, 0.62426, 0.7246720000000001, 0.7300800000000001, 0.9196, 1.131184, 1.675872, 2.346616]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 95<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.22 cm^3<br>Expon. growth rate: 0.06 1/day<br>Lin. growth rate: 756205776436.28 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 95\", \"line\": {\"color\": \"#00CC96\"}, \"mode\": \"lines\", \"name\": \"ID: 95\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.2210876623511744, 0.236670303601348, 0.25332619228008374, 0.27115182240038904, 0.29023057162747407, 0.31065350086853816, 0.33251608267689536, 0.35591938352513486, 0.3809679710921989, 0.40778482443321573, 0.43648413058095537, 0.4672078857108866, 0.5000905216460154, 0.5352887308029428, 0.5729653031720112, 0.6132887686698211, 0.6564588544292062, 0.7026593868602096, 0.7521180625949911, 0.8050533115690113, 0.8617148881406886, 0.9223679176776022, 0.9872813737416133, 1.0567768062870813, 1.1311515448815266, 1.2107699836449564, 1.2959867443009407, 1.3871998603535256, 1.48484132240592, 1.589340283484256, 1.7012143008811647, 1.8209446249155778, 1.9491140292289253, 2.0862986249358344, 2.233132226115674, 2.390319127665788, 2.558543707686258, 2.7386387819090046, 2.931383787789195, 3.1377101179329103, 3.35855430332557, 3.594924729545583, 3.847970305262478, 4.118781853656844, 4.40869910332753, 4.718985249331035, 5.0511277958997765, 5.4066501305898615, 5.787155113342906, 6.194518002725285]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 136<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 136\", \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 136\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.1185885, 0.175071, 0.22999200000000006, 0.3026885, 0.3026885, 0.37044, 0.5341545, 0.651688, 0.7212869999999999, 0.78732, 0.8529505000000001, 1.104558, 1.1328799999999999, 1.4593425]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 136<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.15 cm^3<br>Expon. growth rate: 0.05 1/day<br>Lin. growth rate: 0.13 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 136\", \"line\": {\"color\": \"#AB63FA\"}, \"mode\": \"lines\", \"name\": \"ID: 136\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.1489261709396449, 0.1579724344976988, 0.16748357656959442, 0.17749239035583936, 0.18801930770474395, 0.19908367441833577, 0.21069874507891198, 0.22288213577621274, 0.2356518464625913, 0.24902416081329326, 0.26301668584941224, 0.2776445332394774, 0.2929226077890455, 0.3088683386224854, 0.32549527065008155, 0.3428119899577106, 0.3608364758767259, 0.3795818728139921, 0.39904946089987, 0.41925624350690127, 0.4402139519770716, 0.4619194761136211, 0.48438514165685265, 0.5076204179546976, 0.5316228565119956, 0.5563953448942008, 0.5819461544993533, 0.6082735997651081, 0.6353720379236856, 0.6632479842120895, 0.6918983431941538, 0.7213033913116794, 0.7514696441482791, 0.7823947665415927, 0.8140766888933925, 0.8465136071695835, 0.8797039829002026, 0.9136291688548364, 0.948278989151663, 0.9836520873024414, 1.0197399531688447, 1.056533160104125, 1.0940195543939095, 1.1321889860995005, 1.1710295093471232, 1.2105283979417254, 1.2506778996725196, 1.2914684398102296, 1.332884883787669, 1.3749143688373249]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 140<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 140\", \"marker\": {\"color\": \"#FFA15A\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 140\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.0793305, 0.12685200000000002, 0.146072, 0.261121, 0.34574400000000005, 0.3552, 0.41905, 0.48029799999999995, 0.556668, 0.8089919999999999, 0.8573040000000001, 1.097675, 1.992144, 2.1225820000000004]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 140<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.00 cm^3<br>Expon. growth rate: -5.89 1/day<br>Lin. growth rate: 0.05 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 140\", \"line\": {\"color\": \"#FFA15A\"}, \"mode\": \"lines\", \"name\": \"ID: 140\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.0042137209214960485, 0.04381414312778873, 0.07598843282818003, 0.10732352877276732, 0.13826510918019466, 0.16901280665644683, 0.19963325033565474, 0.23013463746066648, 0.26053879582952755, 0.2908781278600614, 0.32116117982472897, 0.3513992012963601, 0.3815985835322687, 0.4117695761363211, 0.44191441083513117, 0.47203728615206875, 0.5021378602872361, 0.5322178999855297, 0.5622816428374509, 0.5923291808631274, 0.6223621091569475, 0.6523856341307996, 0.6824009298667245, 0.7124101359478013, 0.7424165054839637, 0.7724231536741206, 0.8024322903416767, 0.8324461543486963, 0.8624657813305121, 0.8924945577738864, 0.9225349849074114, 0.9525895639596784, 0.9826607961592798, 1.0127416757087533, 1.042835882918851, 1.0729469840751489, 1.1030764768707675, 1.1332258589988278, 1.1633895006659771, 1.1935528230839514, 1.223726625761042, 1.253910355684912, 1.2841034598432255, 1.3143053852236457, 1.3445088704072305, 1.374715291069105, 1.4049242880693775, 1.4351346820089368, 1.4653452934886713, 1.4955526908123833]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 155<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 155\", \"marker\": {\"color\": \"#19D3F3\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 155\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25], \"y\": [0.105875, 0.167706, 0.35632800000000003, 0.6489600000000001, 0.692224, 0.7300800000000001, 0.81648, 1.4949540000000001, 1.5166985, 1.72405, 1.637784, 2.25108]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 155<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.13 cm^3<br>Expon. growth rate: 0.20 1/day<br>Lin. growth rate: 0.11 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 155\", \"line\": {\"color\": \"#19D3F3\"}, \"mode\": \"lines\", \"name\": \"ID: 155\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.13289521677814017, 0.15586920871402227, 0.18118925396967, 0.20882047740573442, 0.23868362791706255, 0.2706758377485569, 0.3046834885102385, 0.3405838438248227, 0.3782513382850754, 0.41756819152723196, 0.4584246708596359, 0.5006973237948031, 0.5442790410872245, 0.5890674149399729, 0.6349677798519743, 0.6818840234493424, 0.7297492841515331, 0.7784741694172376, 0.8280183804028716, 0.8783030406571601, 0.9292873216792555, 0.9809074563461092, 1.0331067938492249, 1.0858661994971082, 1.1391389992764758, 1.1928876081401072, 1.2470853950810485, 1.3017078574129268, 1.3567325201775484, 1.4121314253346946, 1.4678735871115358, 1.5239448127518067, 1.580328096643315, 1.6370103326334062, 1.6939788318921623, 1.7512216563364982, 1.8087045707404845, 1.866428008542508, 1.9243841566008606, 1.982567667258475, 2.0409756583429273, 2.0995705233258866, 2.1583472857540658, 2.2173106078061418, 2.276456839455631, 2.335783845789713, 2.395277456885177, 2.4549070196536986, 2.514685274918651, 2.5746071721699417]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 169<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 169\", \"marker\": {\"color\": \"#FF6692\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 169\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.123008, 0.128774, 0.1764, 0.20516650000000006, 0.24605349999999998, 0.2788425, 0.333036, 0.35644499999999996, 0.39285, 0.479859, 0.5390550000000001, 0.6354195, 0.7146180000000001, 0.7469865]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 169<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.12 cm^3<br>Expon. growth rate: 0.04 1/day<br>Lin. growth rate: 0.07 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 169\", \"line\": {\"color\": \"#FF6692\"}, \"mode\": \"lines\", \"name\": \"ID: 169\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.1233297930696544, 0.12917400904675988, 0.13524240697791065, 0.14155374353960912, 0.14811464101739308, 0.15493194582729886, 0.16201658121824938, 0.1693688536738379, 0.176992422656531, 0.18489914137655375, 0.1930887146082162, 0.20156648820532647, 0.21034075868023452, 0.21941496418732415, 0.22879406890233944, 0.23848281074659186, 0.24848635900032645, 0.258807141441921, 0.26944670986386376, 0.28041167953452695, 0.29170658292664337, 0.3033359525129458, 0.3152996664311165, 0.32759353249554196, 0.340226806872561, 0.35320268111674563, 0.36652434678266804, 0.38019074829383587, 0.3941917874060112, 0.40853744948066195, 0.42322923742683677, 0.43826865415358385, 0.45365489272456616, 0.46937629082333426, 0.4854408061711596, 0.5018485028549898, 0.5185994449617725, 0.5356929480717494, 0.5531184676192257, 0.5708815551328771, 0.5889818970632519, 0.6074027426501095, 0.6261526950313202, 0.645231754206884, 0.6646230290412768, 0.6843342378170659, 0.7043658486600162, 0.7246936223832026, 0.7453246793920194, 0.7662597980987639]}, {\"hovertemplate\": \"<b>Measurement </b><br>ID: 170<br>Time: %{x:} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><extra></extra>\", \"legendgroup\": \"ID: 170\", \"marker\": {\"color\": \"#B6E880\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"mode\": \"markers\", \"name\": \"ID: 170\", \"showlegend\": true, \"type\": \"scatter\", \"x\": [0, 2, 4, 7, 9, 11, 14, 16, 18, 21, 23, 25, 28, 30], \"y\": [0.0800565, 0.094221, 0.10933, 0.158994, 0.17615699999999998, 0.19407850000000001, 0.2041605, 0.246402, 0.3050865, 0.3683265, 0.41817600000000005, 0.4396155, 0.5661554999999999, 0.6206265000000001]}, {\"hovertemplate\": \"<b>Simulation </b><br>ID: 170<br>Time: %{x:.0f} day<br>Tumour volume: %{y:.02f} cm^3<br>Cancer type: LXF A677<br><br><b>Parameter estimates </b><br>Initial tumour volume: 0.09 cm^3<br>Expon. growth rate: 0.04 1/day<br>Lin. growth rate: 0.19 cm^3/day<br><extra></extra>\", \"legendgroup\": \"ID: 170\", \"line\": {\"color\": \"#B6E880\"}, \"mode\": \"lines\", \"name\": \"ID: 170\", \"showlegend\": false, \"type\": \"scatter\", \"x\": [0.0, 0.6122448979591837, 1.2244897959183674, 1.836734693877551, 2.4489795918367347, 3.0612244897959187, 3.673469387755102, 4.285714285714286, 4.8979591836734695, 5.510204081632653, 6.122448979591837, 6.73469387755102, 7.346938775510204, 7.959183673469388, 8.571428571428571, 9.183673469387756, 9.795918367346939, 10.408163265306122, 11.020408163265307, 11.63265306122449, 12.244897959183675, 12.857142857142858, 13.46938775510204, 14.081632653061225, 14.693877551020408, 15.306122448979592, 15.918367346938776, 16.53061224489796, 17.142857142857142, 17.755102040816325, 18.367346938775512, 18.979591836734695, 19.591836734693878, 20.20408163265306, 20.816326530612244, 21.42857142857143, 22.040816326530614, 22.653061224489797, 23.26530612244898, 23.877551020408163, 24.48979591836735, 25.102040816326532, 25.714285714285715, 26.3265306122449, 26.93877551020408, 27.551020408163264, 28.16326530612245, 28.775510204081634, 29.387755102040817, 30.0], \"y\": [0.0870275375518596, 0.09084972926671613, 0.09482465244458126, 0.0989668045108156, 0.10328295827323132, 0.10777961353435146, 0.112463886573618, 0.1173432572032446, 0.1224251875171039, 0.12771794037200498, 0.1332285081655138, 0.1389646609526948, 0.14493641782024883, 0.15115067302872498, 0.15761543336910186, 0.16434225508896153, 0.17133843913311117, 0.17861265626950276, 0.18617654937539152, 0.19403905567887608, 0.20220923783088274, 0.21069918555119863, 0.21951975537469556, 0.22868043379765435, 0.2381914972690412, 0.24806322439640457, 0.2583076625475848, 0.2689382848671039, 0.2799644564045343, 0.29139750266033276, 0.303248848637231, 0.3155301617480711, 0.32825459283454717, 0.341433364529537, 0.35507861726365925, 0.3692026242369256, 0.3838177914187406, 0.3989347796524953, 0.4145663230198504, 0.43072507578582064, 0.44742349331525305, 0.4646741167724575, 0.48248721365614217, 0.5008734479647304, 0.5198461585439019, 0.5394172433419175, 0.5595985871555587, 0.5803980724210378, 0.6018154101543338, 0.6238712474264247]}],\n",
        "                        {\"autosize\": true, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"yaxis.type\": \"linear\"}], \"label\": \"Linear y-scale\", \"method\": \"relayout\"}, {\"args\": [{\"yaxis.type\": \"log\"}], \"label\": \"Log y-scale\", \"method\": \"relayout\"}], \"direction\": \"left\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.15, \"yanchor\": \"top\"}], \"xaxis\": {\"title\": {\"text\": \"$\\\\text{Time in day}$\"}}, \"yaxis\": {\"title\": {\"text\": \"$\\\\text{Tumour volume in cm}^3$\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('927fb346-b2e1-4e32-84ce-fc768cca5c4f');\n",
+       "var gd = document.getElementById('13d018dc-4ebb-4a6a-84fc-cfe99eb353ce');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -4504,9 +4507,16 @@
     "To test the stability of the CMA-ES optimiser, we choose different starting points for a number of optimisations (uniform in $[10^{-3}, 10^3]$ for each parameter). Ideally we would like to see that each optimisation returns very similar model parameters for a mouse. This would give us confidence to interpret those model parameters in a biological context."
    ]
   },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Run optimisation"
+   ]
+  },
   {
    "cell_type": "code",
-   "execution_count": 4,
+   "execution_count": 1,
    "metadata": {
     "tags": []
    },
@@ -4514,7 +4524,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "ee2c6d8c70a2421aac95badd2c5008b9",
+       "model_id": "d6989a308e4440c2aa1b0b0eb155393d",
        "version_major": 2,
        "version_minor": 0
       },
@@ -4529,33 +4539,6 @@
      "name": "stdout",
      "output_type": "stream",
      "text": [
-      "\n",
-      "----------------------------------------\n",
-      "Unexpected termination.\n",
-      "Current best score: 1.33601066192236\n",
-      "Current best position:\n",
-      " 5.13963304540006161e-01\n",
-      " 8.99993578900088210e+02\n",
-      " 5.34203544452505896e-02\n",
-      "----------------------------------------\n",
-      "\n",
-      "----------------------------------------\n",
-      "Unexpected termination.\n",
-      "Current best score: 1.1130086375270116\n",
-      "Current best position:\n",
-      "-1.99610483200134387e-01\n",
-      " 8.21124275015820558e+02\n",
-      " 5.97958814459842100e-02\n",
-      "----------------------------------------\n",
-      "\n",
-      "----------------------------------------\n",
-      "Unexpected termination.\n",
-      "Current best score: 1.1170677003709557\n",
-      "Current best position:\n",
-      "-1.96732986821182065e-01\n",
-      " 4.82948382103535550e+02\n",
-      " 5.96854392442308160e-02\n",
-      "----------------------------------------\n",
       "\n"
      ]
     }
@@ -4567,7 +4550,6 @@
     "\n",
     "import os\n",
     "\n",
-    "import myokit\n",
     "import numpy as np\n",
     "import pandas as pd\n",
     "import pints\n",
@@ -4580,72 +4562,36 @@
     "n_runs = 10\n",
     "\n",
     "# Import data\n",
-    "# Get path of current working directory\n",
     "path = os.getcwd()\n",
-    "\n",
-    "# Import LXF A677 control growth data\n",
     "data = pd.read_csv(path + '/data/lxf_control_growth.csv')\n",
     "\n",
     "# Define model\n",
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - Eigenmann et. al.')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=False)\n",
     "\n",
-    "# Define container for the structural model estimates\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
+    "# Define initial parameters\n",
     "n_mice = len(data['#ID'].unique())\n",
-    "n_parameters = 3\n",
-    "parameters = np.empty(shape=(n_mice, n_runs, n_parameters))\n",
-    "\n",
-    "# Define container for the objective function score for the optimised parameters\n",
-    "scores = np.empty(shape=(n_mice, n_runs))\n",
-    "\n",
-    "# Define random starting points over many orders of magnitude\n",
-    "# Shape = (n_runs, n_parameters)\n",
+    "n_parameters = model.n_parameters()\n",
     "initial_parameters = np.random.uniform(low=1E-3, high=1E3, size=(n_runs, n_parameters))\n",
     "\n",
-    "# Find mouse parameters for LXF A677 population\n",
+    "# Find parameters for each mouse\n",
+    "parameters = []\n",
+    "scores = []\n",
     "mouse_ids = data['#ID'].unique()\n",
     "for index, mouse_id in enumerate(tqdm(mouse_ids)):\n",
-    "    # Create mask for mouse with specfied ID\n",
+    "    # Get data\n",
     "    mouse_mask = data['#ID'] == mouse_id\n",
-    "\n",
-    "    # Get relevant time points\n",
     "    times = data[mouse_mask]['TIME in day'].to_numpy()\n",
-    "\n",
-    "    # Get measured tumour volumes\n",
     "    observed_volumes = data[mouse_mask]['TUMOUR VOLUME in cm^3'].to_numpy()\n",
     "\n",
     "    # Create inverse problem\n",
     "    problem = pints.SingleOutputProblem(model, times, observed_volumes)\n",
-    "\n",
-    "    # Create sum of squares error objective function\n",
     "    error = pints.SumOfSquaresError(problem)\n",
     "\n",
     "    # Run optimisation multiple times\n",
-    "    for run_id, initial_params in enumerate(initial_parameters):\n",
-    "        # Create optimisation controller with a CMA-ES optimiser\n",
-    "        optimiser = pints.OptimisationController(\n",
-    "            function=error,\n",
-    "            x0=initial_params,\n",
-    "            method=pints.CMAES)\n",
-    "\n",
-    "        # Disable logging mode\n",
-    "        optimiser.set_log_to_screen(False)\n",
-    "\n",
-    "        # Parallelise optimisation\n",
-    "        optimiser.set_parallel(True)\n",
-    "\n",
-    "        # Find optimal parameters\n",
-    "        try:\n",
-    "            estimates, score = optimiser.run()\n",
-    "        except:\n",
-    "            # If inference breaks fill estimates with nan\n",
-    "            estimates = np.array([np.nan, np.nan, np.nan])\n",
-    "            score = np.nan\n",
-    "\n",
-    "        # Save estimates and score\n",
-    "        parameters[index, run_id, :] = estimates\n",
-    "        scores[index, run_id] = score"
+    "    p, s = pkpd.optimise(error, pints.CMAES, initial_parameters, n_runs)\n",
+    "    parameters += [p]\n",
+    "    scores += [s]"
    ]
   },
   {
@@ -4655,9 +4601,16 @@
     "The \"Unexpected termination\" message indicates that we ran into optimisation errors for at least one run. Let us explore the parameters from the successfull optimisations below."
    ]
   },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Visualise results"
+   ]
+  },
   {
    "cell_type": "code",
-   "execution_count": 5,
+   "execution_count": 2,
    "metadata": {},
    "outputs": [
     {
@@ -4687,16 +4640,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.14132786245444803,
-          0.1918083414781658,
-          0.03588752368134002,
-          0.19180620174770074,
-          0.13932335416614253,
-          0.13900768778497158,
-          0.19178175799366706,
-          0.19179757183406168,
-          0.13917075709578128,
-          0.19183783373639074
+          0.13935806757400998,
+          0.1396226072030807,
+          0.035508938041871975,
+          0.13990899121390132,
+          0.13952441210302588,
+          0.13932310904498357,
+          0.13924816494827724,
+          0.19183882386719645,
+          0.1918080212403739,
+          0.1377177584106959
          ]
         },
         {
@@ -4719,16 +4672,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.2655270167589511,
-          -1258.347712549018,
-          1763.753365283403,
-          -1302.2518888818047,
-          0.27541146163988744,
-          0.2758701548659919,
-          -845.5241734891067,
-          -864.5911212101862,
-          0.27569463747883705,
-          -48.274489906241286
+          0.27525576392952505,
+          0.2748332727015665,
+          3047.535103900365,
+          0.27440169164239936,
+          0.27493978262384133,
+          0.27541194987816753,
+          0.2755443298408985,
+          -169.12736093627885,
+          -899.2090844550258,
+          0.28495322077003005
          ]
         },
         {
@@ -4751,16 +4704,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13244656044790434,
-          -109.91104374469748,
-          0.10083332422197865,
-          -3018.9511092845255,
-          0.13096879744244216,
-          0.1309317248638247,
-          -1848.2176867495014,
-          -4045.6535581363983,
-          0.13096592155801187,
-          -711.603171602045
+          0.13096237273493913,
+          0.1309725445273322,
+          0.10085586402510328,
+          0.131033441562431,
+          0.13096505131829914,
+          0.13096880314915946,
+          0.13097060306044578,
+          -236.65830934530294,
+          -3154.6490984310312,
+          0.1296196269641453
          ]
         },
         {
@@ -4783,16 +4736,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.03190810516271313,
-          15.910377216625928,
-          0.0689371918283223,
-          15.910378828519807,
-          0.031860188091842497,
-          0.03186148320799623,
-          15.910378793521,
-          15.910378441750906,
-          0.03186038158699445,
-          15.91037618922035
+          0.03186105392432852,
+          0.03186097817936808,
+          0.06891972927157793,
+          0.031861450382161226,
+          0.03186173826542541,
+          0.031860188091924216,
+          0.03186034231728075,
+          15.91037794433139,
+          15.910378060887343,
+          0.03190273166312796
          ]
         },
         {
@@ -4815,16 +4768,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12263316766110471,
-          0.07718912253382017,
-          0.05752066220207564,
-          0.07479934071312064,
-          0.0772475082986968,
-          0.05752067443484504,
-          0.07724745936627458,
-          0.05752068504452631,
-          0.05752067086032227,
-          0.07454906687898696
+          0.05752673046606138,
+          0.05752067206489103,
+          0.057520672882069836,
+          0.0772497074680969,
+          0.07724737728755357,
+          0.07484937108758243,
+          0.07455445302685904,
+          0.07726892310905091,
+          0.07725074946828536,
+          0.057519765072660364
          ]
         },
         {
@@ -4847,16 +4800,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.026475456195654896,
-          -908.2139598924246,
-          1282.6397781503802,
-          0.16503501676452526,
-          -2741.856148013847,
-          1282.638754459437,
-          -232.31821546389398,
-          1282.6380003039608,
-          1282.6388986186103,
-          0.16798414699965702
+          390.847858183724,
+          1282.6387128545787,
+          1282.6389412103115,
+          -353.4102630867677,
+          -1150.376983775699,
+          0.1672061396383554,
+          0.1679117074458703,
+          -43.111369309004225,
+          -71.13978793777125,
+          371.4557112073267
          ]
         },
         {
@@ -4879,16 +4832,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          -2299814047.9147706,
-          -29.762236888355496,
-          0.016438401692734625,
-          0.02038880877409421,
-          -127.4300021338397,
-          0.016438400495350943,
-          -1730.69813828683,
-          0.016438400122188848,
-          0.016438401121433115,
-          0.020311912583751264
+          0.016439696122867387,
+          0.016438399976988566,
+          0.016438400629195875,
+          -77.21950729526583,
+          -2317.391966789073,
+          0.02030532109349976,
+          0.020313873867423157,
+          -1953.0751387602957,
+          -1908.1432619306588,
+          0.01644047021159452
          ]
         },
         {
@@ -4911,16 +4864,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.015162785887382535,
-          1.6108443847589196,
-          0.008274945550948421,
-          0.007450327517851704,
-          1.6108446442685,
-          0.008274945550940821,
-          1.6108425738229117,
-          0.008274945550944074,
-          0.008274945550941418,
-          0.007448232521881679
+          0.008274291669390452,
+          0.008274945550944322,
+          0.008274945550942643,
+          1.6108443968117925,
+          1.6108446064193396,
+          0.007450202717965164,
+          0.007448217820458669,
+          1.6108438896246646,
+          1.6108437721010462,
+          0.00827438026026067
          ]
         },
         {
@@ -4943,16 +4896,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.2210876790344318,
-          1.2639619624838448e-7,
-          -0.0010851100428051394,
-          0.18620002123922422,
-          0.18619869803889988,
-          1.2001658305624768e-7,
-          0.18620002429018126,
-          0.1861966220819822,
-          null,
-          0.18619343776737876
+          0.0005613654182572577,
+          0.009199238774310262,
+          -2.0693952839849787e-05,
+          -8.165750984873074e-07,
+          0.0013523211870147165,
+          -1.3430301548489286e-07,
+          0.001781437448647869,
+          0.18620003812535055,
+          0.2727725320694456,
+          -5.436236384039323e-06
          ]
         },
         {
@@ -4975,16 +4928,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05552722990437244,
-          202.06998822391395,
-          933.4162605533169,
-          -2546.8568971105215,
-          -197.10290662032563,
-          732.6947683047204,
-          -628.9522289232848,
-          -2570.0277289240144,
-          null,
-          -105.88425378074933
+          747.0980323155678,
+          -29.914375096649565,
+          866.8124130876977,
+          815.8266748562025,
+          1129.5623388401802,
+          788.8883479799808,
+          1148.994641948823,
+          -1451.0441459536328,
+          0.041268958851713146,
+          1399.3357365758436
          ]
         },
         {
@@ -5007,16 +4960,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          802502158732.561,
-          0.08846320320200322,
-          0.08853724785754515,
-          -1820.3357199421673,
-          242.85270210822483,
-          0.08845780815861247,
-          -91.07602285967283,
-          -726.5227824208409,
-          null,
-          -389.0814929975521
+          0.08837276256745735,
+          0.08723497219265819,
+          0.08847603860231773,
+          0.08837337192931488,
+          0.08838355244244209,
+          0.08834650167259217,
+          0.08822797091911842,
+          -144.1195120759364,
+          -0.40746954917603173,
+          0.08844162562253913
          ]
         },
         {
@@ -5039,16 +4992,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0992972607374313,
-          0.5329553558254354,
-          0.5365307211684747,
-          12.133283106840794,
-          12.133281391437738,
-          0.5354975445847414,
-          12.133282780436698,
-          12.133283181675981,
-          null,
-          12.133282086571846
+          0.536789148848769,
+          0.5387618495076001,
+          0.5362303591799356,
+          0.5365058993119068,
+          0.536895277357164,
+          0.534786195765319,
+          0.5369470171001576,
+          12.133279270522781,
+          0.07277697701595628,
+          0.5369365196994488
          ]
         },
         {
@@ -5071,16 +5024,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14903244881437866,
-          0.11858869596256137,
-          0.1489737871302079,
-          0.01904533402855572,
-          0.1175711643759342,
-          0.14823942496998052,
-          0.11858852361228875,
-          0.1496840121678373,
-          0.14832387516152662,
-          0.11858815607214884
+          0.1491119004673117,
+          0.148260215814077,
+          0.1479327236487746,
+          0.14964412494710022,
+          0.1476216257096094,
+          0.018227700342924574,
+          0.14772359735108512,
+          0.11858859869741575,
+          0.11864006871976325,
+          0.1495785943419326
          ]
         },
         {
@@ -5103,16 +5056,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05425210775330457,
-          -1893.8320412947776,
-          0.054262469158128976,
-          1623.7361157023902,
-          -1.8680738629522722,
-          0.05476869621106232,
-          -738.5873385669606,
-          0.05373222198275952,
-          0.054767291049302655,
-          -1597.0561643731041
+          0.05422778316064978,
+          0.054805138537064105,
+          0.0548906019397034,
+          0.05375369612076491,
+          0.0029035366920595607,
+          1199.4741900835618,
+          0.055258233265326424,
+          -609.0322329139575,
+          -0.14384987133944094,
+          0.05375509360686332
          ]
         },
         {
@@ -5135,16 +5088,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12881404454422293,
-          -3305.491789523077,
-          0.12878939826270866,
-          0.040770166204450405,
-          28.69428359485122,
-          0.12676103590995783,
-          -1369.2727383598847,
-          0.13106666794753039,
-          0.12679061932825006,
-          399.49900911250177
+          0.1288253903509171,
+          0.1267707888322742,
+          0.1266448341156006,
+          0.13097370948029055,
+          86.28373542157529,
+          0.04081470694896092,
+          0.12469229678038544,
+          -88.05893419414014,
+          6.39587971775984,
+          0.13089094346131966
          ]
         },
         {
@@ -5167,16 +5120,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.040184503448009314,
-          7.614828299495496,
-          0.040184700695023785,
-          0.10938755271389108,
-          7.61480731247398,
-          0.04018048622123809,
-          7.6148285449910045,
-          0.04018732339210497,
-          0.04018094206996036,
-          7.614829035041376
+          0.04018502317470858,
+          0.04018360714313545,
+          0.04018351835721534,
+          0.040186754673166625,
+          5.080202620485118,
+          0.10941716880693551,
+          0.04021197460385084,
+          7.614825205990982,
+          7.556214136410004,
+          0.04019012325035724
          ]
         },
         {
@@ -5199,16 +5152,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.10916877127409325,
-          0.07931614836850054,
-          null,
-          0.07935327319557924,
-          -0.1893827797268466,
-          null,
-          0.07933048862867606,
-          0.0793305095926042,
-          -0.20166917398744955,
-          0.07933050161271447
+          -0.17811641810835527,
+          -0.19528101065732753,
+          0.07932573316212735,
+          0.07875840720621717,
+          -0.20472980478533498,
+          -0.19242475059544203,
+          -0.18920712525027872,
+          0.07933076248573996,
+          0.07920850493777237,
+          0.07933051446102338
          ]
         },
         {
@@ -5231,16 +5184,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.045072668193731256,
-          -372.7011822014575,
-          null,
-          -6511.105677046621,
-          464.6367812815005,
-          null,
-          -9413.566503271126,
-          -1094.9679462710315,
-          786.8477304262593,
-          -1492.7177953944679
+          616.3314224005385,
+          1013.5270512647729,
+          -304.17594264220804,
+          -163.40268879586728,
+          896.3100407502038,
+          635.2446332459118,
+          1148.7051508992345,
+          -385.20145758462434,
+          -911.2226268093282,
+          -2095.4516943592475
          ]
         },
         {
@@ -5263,16 +5216,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          -0.6222682323558613,
-          304.71404767820707,
-          null,
-          -47.429135077558755,
-          0.05915351316328102,
-          null,
-          -7356.924765394424,
-          1036.9933204340853,
-          0.059814975801293545,
-          -382.7086435370272
+          0.058549524188444106,
+          0.05952857807581653,
+          50.7488208437163,
+          -82.57476388829865,
+          0.05986400225281952,
+          0.05937633632295753,
+          0.05954638819641425,
+          -1123.2610440096516,
+          1276.721715624401,
+          -510.80723303337857
          ]
         },
         {
@@ -5295,16 +5248,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.130949328033503,
-          12.135807596027139,
-          null,
-          12.135806897873739,
-          1.1161370138341287,
-          null,
-          12.135807596358003,
-          12.135807561619309,
-          1.1143495827510854,
-          12.135806996585465
+          1.1195989109454763,
+          1.1130363195189172,
+          12.135807240812854,
+          12.135805850503633,
+          1.1113043366101003,
+          1.114657298922913,
+          1.1097108797881217,
+          12.13580752603929,
+          12.135807532755809,
+          12.135807446000747
          ]
         },
         {
@@ -5327,16 +5280,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.13327426676964071,
-          0.10580964725619971,
-          0.10587521341103034,
-          0.1058750011761061,
-          0.007803386709519042,
-          0.008048149905454936,
-          0.10587527695854985,
-          0.010804485784492446,
-          0.007881895789125792,
-          0.10587601522198371
+          0.009481839207351406,
+          0.01147214102509777,
+          0.008589069696652955,
+          0.006202411117075212,
+          0.10587585608431076,
+          0.007723929377953506,
+          0.10587522167639221,
+          0.10586945746699969,
+          0.10570484566538954,
+          0.1058657067887093
          ]
         },
         {
@@ -5359,16 +5312,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.19735939401220737,
-          -18.45205195303306,
-          -9438.178864594553,
-          -7096.839870496476,
-          779.3188109455353,
-          576.1809032581483,
-          -2089.3201876194876,
-          16.96572767670504,
-          701.7947976466651,
-          -956.771267559489
+          2.3897956689204625,
+          22.667025916360846,
+          838.7015285161438,
+          370.1561539825027,
+          -1560.6666379747344,
+          789.4504339078898,
+          -1121.0867683221818,
+          -72.12861328363084,
+          -21.204882051874513,
+          -58.876756085519816
          ]
         },
         {
@@ -5391,16 +5344,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.10853692424277184,
-          -262.1263052457411,
-          -844.9914308871221,
-          -2895.4188899189694,
-          0.08033786570724774,
-          0.08032239081846985,
-          -627.3000134484015,
-          0.08027522747331191,
-          0.0803302968040569,
-          412.3797248426809
+          0.08514435780706013,
+          0.08059975333054559,
+          0.08028729477547229,
+          0.08041107584291912,
+          -452.37509689828926,
+          0.08031898629529952,
+          -218.52764397824146,
+          15.321856877205738,
+          -662.3683563469851,
+          17.172257222158315
          ]
         },
         {
@@ -5423,16 +5376,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.2588573465067521,
-          17.512371085742647,
-          17.51238219172336,
-          17.512382147610985,
-          0.2920171877110871,
-          0.2920129943675763,
-          17.512380755012753,
-          0.29068013818727545,
-          0.2920317369718424,
-          17.512381482531403
+          0.2843996458813365,
+          0.29048826733688693,
+          0.2920404664713889,
+          0.29189674246667613,
+          17.512382204616678,
+          0.2920189652472877,
+          17.512381715100627,
+          17.512380715845005,
+          17.512379054474255,
+          17.512379311032884
          ]
         },
         {
@@ -5455,16 +5408,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12380953477472657,
-          0.12298823527115738,
-          0.12380958562995287,
-          0.12316200316235319,
-          0.0662262756957853,
-          0.0662262060717479,
-          0.06622629089009184,
-          0.12300798716889787,
-          0.06622644351418558,
-          0.12300806587569796
+          0.06622647457321464,
+          0.06622339682123456,
+          0.06622649592193663,
+          0.12300773481951591,
+          0.0662262242091626,
+          0.06622324776196409,
+          0.06622335623870475,
+          0.066223344893928,
+          0.12303905088343889,
+          0.12300725996491935
          ]
         },
         {
@@ -5487,16 +5440,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.043031603212493705,
-          -13.258819886685204,
-          0.043031589903992994,
-          -615.1243820146714,
-          448.0132877482733,
-          448.01379788582665,
-          448.01315284962914,
-          -646.8065706946633,
-          448.01234722249086,
-          -2254.427150350503
+          448.011932486501,
+          1211.7610584992888,
+          448.01172542850804,
+          -536.1034290984702,
+          448.01353265114403,
+          1216.8380155150498,
+          1211.716572093114,
+          1211.829546316193,
+          -462.25145729468926,
+          -846.052347960286
          ]
         },
         {
@@ -5519,16 +5472,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07299522781465079,
-          187.288769246147,
-          0.07299523377584204,
-          -2191.548478456097,
-          0.021297789818473547,
-          0.021297794967111996,
-          0.02129778728815508,
-          -415.2263629747105,
-          0.021297790914357635,
-          -1807.1915158923166
+          0.021297779997111764,
+          0.02129621208834603,
+          0.02129777675438024,
+          175.15741659682593,
+          0.02129778715991995,
+          0.02129621496669821,
+          0.021296213990316636,
+          0.021296212838696395,
+          -527.4283224453598,
+          -203.35817538663073
          ]
         },
         {
@@ -5551,16 +5504,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.002915292959204741,
-          2.6136529230092957,
-          0.002915292959218004,
-          2.6136559853063126,
-          0.0189408254351519,
-          0.01894082543525065,
-          0.01894082543521825,
-          2.6136560129682613,
-          0.01894082543577636,
-          2.6136562092778544
+          0.01894082543530327,
+          0.018944615918947427,
+          0.01894082543521047,
+          2.6136561341712916,
+          0.018940825435215056,
+          0.018944615980810382,
+          0.018944615918916344,
+          0.01894461591890988,
+          2.613656161786167,
+          2.61365620927786
          ]
         },
         {
@@ -5583,16 +5536,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08718955266753119,
-          0.0801034268418984,
-          0.026942633466316097,
-          0.026906092507107775,
-          0.08005575386103733,
-          0.02693929664451729,
-          0.02690602148024295,
-          0.08704782016943194,
-          0.02690613254119551,
-          0.0800605995005297
+          0.026925990533115424,
+          0.026939214812297576,
+          0.08704781978401278,
+          0.08005750743465542,
+          0.026939240367016445,
+          0.026925694521943166,
+          0.026922604323894147,
+          0.08007790249822795,
+          0.0800564633038269,
+          0.08006615752047912
          ]
         },
         {
@@ -5615,16 +5568,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.03604579868582253,
-          -26.318970297771013,
-          819.4858122440955,
-          721.0429467580077,
-          -2244.5798742537604,
-          830.5893340628523,
-          721.0327421367886,
-          0.03617215606124126,
-          721.0236716156231,
-          -727.4386737638289
+          553.7761079834291,
+          830.5918055082143,
+          0.036172158004522593,
+          -1883.7454358196346,
+          830.5910089551147,
+          553.7812207303185,
+          1894.202249127652,
+          -2959.490932155345,
+          -1366.918125180187,
+          -330.8569790929731
          ]
         },
         {
@@ -5647,16 +5600,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.19864982362212236,
-          228.6451086839992,
-          0.01732978708494345,
-          0.017332437420532573,
-          -837.5304570718794,
-          0.017329877438754488,
-          0.017332441615070242,
-          0.1932583954550811,
-          0.017332436315855914,
-          -771.0044288909901
+          0.017331486305579014,
+          0.017329883645375736,
+          0.1932584054939813,
+          -1750.0114754326557,
+          0.017329881146011045,
+          0.017331501052531645,
+          0.01732993663581608,
+          645.0748031481855,
+          -390.42015231250457,
+          -357.48184275333716
          ]
         },
         {
@@ -5679,16 +5632,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0023157518228974876,
-          1.5197850638013948,
-          0.022871056214652574,
-          0.022869807188109652,
-          1.5197873806295572,
-          0.02287048849419741,
-          0.022869807187950585,
-          0.0023155933407878492,
-          0.022869807188066495,
-          1.5197873540151274
+          0.022868138367502122,
+          0.022870488494213605,
+          0.0023155933407792996,
+          1.51978735171744,
+          0.02287048849419275,
+          0.02286813836753069,
+          0.02287345606540325,
+          1.5197873394630397,
+          1.5197872595369555,
+          1.519787327911993
          ]
         }
        ],
@@ -6864,52 +6817,7 @@
          }
         }
        }
-      },
-      "text/html": [
-       "<div>\n",
-       "        \n",
-       "        \n",
-       "            <div id=\"793a778e-7d27-49fd-ac4d-49078280d763\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
-       "            <script type=\"text/javascript\">\n",
-       "                require([\"plotly\"], function(Plotly) {\n",
-       "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
-       "                    \n",
-       "                if (document.getElementById(\"793a778e-7d27-49fd-ac4d-49078280d763\")) {\n",
-       "                    Plotly.newPlot(\n",
-       "                        '793a778e-7d27-49fd-ac4d-49078280d763',\n",
-       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.14132786245444803, 0.1918083414781658, 0.03588752368134002, 0.19180620174770074, 0.13932335416614253, 0.13900768778497158, 0.19178175799366706, 0.19179757183406168, 0.13917075709578128, 0.19183783373639074]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.2655270167589511, -1258.347712549018, 1763.753365283403, -1302.2518888818047, 0.27541146163988744, 0.2758701548659919, -845.5241734891067, -864.5911212101862, 0.27569463747883705, -48.274489906241286]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13244656044790434, -109.91104374469748, 0.10083332422197865, -3018.9511092845255, 0.13096879744244216, 0.1309317248638247, -1848.2176867495014, -4045.6535581363983, 0.13096592155801187, -711.603171602045]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.03190810516271313, 15.910377216625928, 0.0689371918283223, 15.910378828519807, 0.031860188091842497, 0.03186148320799623, 15.910378793521, 15.910378441750906, 0.03186038158699445, 15.91037618922035]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12263316766110471, 0.07718912253382017, 0.05752066220207564, 0.07479934071312064, 0.0772475082986968, 0.05752067443484504, 0.07724745936627458, 0.05752068504452631, 0.05752067086032227, 0.07454906687898696]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.026475456195654896, -908.2139598924246, 1282.6397781503802, 0.16503501676452526, -2741.856148013847, 1282.638754459437, -232.31821546389398, 1282.6380003039608, 1282.6388986186103, 0.16798414699965702]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [-2299814047.9147706, -29.762236888355496, 0.016438401692734625, 0.02038880877409421, -127.4300021338397, 0.016438400495350943, -1730.69813828683, 0.016438400122188848, 0.016438401121433115, 0.020311912583751264]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.015162785887382535, 1.6108443847589196, 0.008274945550948421, 0.007450327517851704, 1.6108446442685, 0.008274945550940821, 1.6108425738229117, 0.008274945550944074, 0.008274945550941418, 0.007448232521881679]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2210876790344318, 1.2639619624838448e-07, -0.0010851100428051394, 0.18620002123922422, 0.18619869803889988, 1.2001658305624768e-07, 0.18620002429018126, 0.1861966220819822, null, 0.18619343776737876]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05552722990437244, 202.06998822391395, 933.4162605533169, -2546.8568971105215, -197.10290662032563, 732.6947683047204, -628.9522289232848, -2570.0277289240144, null, -105.88425378074933]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [802502158732.561, 0.08846320320200322, 0.08853724785754515, -1820.3357199421673, 242.85270210822483, 0.08845780815861247, -91.07602285967283, -726.5227824208409, null, -389.0814929975521]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0992972607374313, 0.5329553558254354, 0.5365307211684747, 12.133283106840794, 12.133281391437738, 0.5354975445847414, 12.133282780436698, 12.133283181675981, null, 12.133282086571846]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14903244881437866, 0.11858869596256137, 0.1489737871302079, 0.01904533402855572, 0.1175711643759342, 0.14823942496998052, 0.11858852361228875, 0.1496840121678373, 0.14832387516152662, 0.11858815607214884]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05425210775330457, -1893.8320412947776, 0.054262469158128976, 1623.7361157023902, -1.8680738629522722, 0.05476869621106232, -738.5873385669606, 0.05373222198275952, 0.054767291049302655, -1597.0561643731041]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12881404454422293, -3305.491789523077, 0.12878939826270866, 0.040770166204450405, 28.69428359485122, 0.12676103590995783, -1369.2727383598847, 0.13106666794753039, 0.12679061932825006, 399.49900911250177]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.040184503448009314, 7.614828299495496, 0.040184700695023785, 0.10938755271389108, 7.61480731247398, 0.04018048622123809, 7.6148285449910045, 0.04018732339210497, 0.04018094206996036, 7.614829035041376]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10916877127409325, 0.07931614836850054, null, 0.07935327319557924, -0.1893827797268466, null, 0.07933048862867606, 0.0793305095926042, -0.20166917398744955, 0.07933050161271447]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.045072668193731256, -372.7011822014575, null, -6511.105677046621, 464.6367812815005, null, -9413.566503271126, -1094.9679462710315, 786.8477304262593, -1492.7177953944679]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [-0.6222682323558613, 304.71404767820707, null, -47.429135077558755, 0.05915351316328102, null, -7356.924765394424, 1036.9933204340853, 0.059814975801293545, -382.7086435370272]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.130949328033503, 12.135807596027139, null, 12.135806897873739, 1.1161370138341287, null, 12.135807596358003, 12.135807561619309, 1.1143495827510854, 12.135806996585465]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13327426676964071, 0.10580964725619971, 0.10587521341103034, 0.1058750011761061, 0.007803386709519042, 0.008048149905454936, 0.10587527695854985, 0.010804485784492446, 0.007881895789125792, 0.10587601522198371]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19735939401220737, -18.45205195303306, -9438.178864594553, -7096.839870496476, 779.3188109455353, 576.1809032581483, -2089.3201876194876, 16.96572767670504, 701.7947976466651, -956.771267559489]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10853692424277184, -262.1263052457411, -844.9914308871221, -2895.4188899189694, 0.08033786570724774, 0.08032239081846985, -627.3000134484015, 0.08027522747331191, 0.0803302968040569, 412.3797248426809]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2588573465067521, 17.512371085742647, 17.51238219172336, 17.512382147610985, 0.2920171877110871, 0.2920129943675763, 17.512380755012753, 0.29068013818727545, 0.2920317369718424, 17.512381482531403]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12380953477472657, 0.12298823527115738, 0.12380958562995287, 0.12316200316235319, 0.0662262756957853, 0.0662262060717479, 0.06622629089009184, 0.12300798716889787, 0.06622644351418558, 0.12300806587569796]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.043031603212493705, -13.258819886685204, 0.043031589903992994, -615.1243820146714, 448.0132877482733, 448.01379788582665, 448.01315284962914, -646.8065706946633, 448.01234722249086, -2254.427150350503]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07299522781465079, 187.288769246147, 0.07299523377584204, -2191.548478456097, 0.021297789818473547, 0.021297794967111996, 0.02129778728815508, -415.2263629747105, 0.021297790914357635, -1807.1915158923166]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.002915292959204741, 2.6136529230092957, 0.002915292959218004, 2.6136559853063126, 0.0189408254351519, 0.01894082543525065, 0.01894082543521825, 2.6136560129682613, 0.01894082543577636, 2.6136562092778544]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08718955266753119, 0.0801034268418984, 0.026942633466316097, 0.026906092507107775, 0.08005575386103733, 0.02693929664451729, 0.02690602148024295, 0.08704782016943194, 0.02690613254119551, 0.0800605995005297]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.03604579868582253, -26.318970297771013, 819.4858122440955, 721.0429467580077, -2244.5798742537604, 830.5893340628523, 721.0327421367886, 0.03617215606124126, 721.0236716156231, -727.4386737638289]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19864982362212236, 228.6451086839992, 0.01732978708494345, 0.017332437420532573, -837.5304570718794, 0.017329877438754488, 0.017332441615070242, 0.1932583954550811, 0.017332436315855914, -771.0044288909901]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0023157518228974876, 1.5197850638013948, 0.022871056214652574, 0.022869807188109652, 1.5197873806295572, 0.02287048849419741, 0.022869807187950585, 0.0023155933407878492, 0.022869807188066495, 1.5197873540151274]}],\n",
-       "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"visible\": [true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 40\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 94\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 95\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 136\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 140\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 155\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false]}], \"label\": \"ID: 169\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true]}], \"label\": \"ID: 170\", \"method\": \"restyle\"}], \"direction\": \"right\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"yaxis\": {\"title\": {\"text\": \"Estimates\"}}},\n",
-       "                        {\"responsive\": true}\n",
-       "                    ).then(function(){\n",
-       "                            \n",
-       "var gd = document.getElementById('793a778e-7d27-49fd-ac4d-49078280d763');\n",
-       "var x = new MutationObserver(function (mutations, observer) {{\n",
-       "        var display = window.getComputedStyle(gd).display;\n",
-       "        if (!display || display === 'none') {{\n",
-       "            console.log([gd, 'removed!']);\n",
-       "            Plotly.purge(gd);\n",
-       "            observer.disconnect();\n",
-       "        }}\n",
-       "}});\n",
-       "\n",
-       "// Listen for the removal of the full notebook cells\n",
-       "var notebookContainer = gd.closest('#notebook-container');\n",
-       "if (notebookContainer) {{\n",
-       "    x.observe(notebookContainer, {childList: true});\n",
-       "}}\n",
-       "\n",
-       "// Listen for the clearing of the current output cell\n",
-       "var outputEl = gd.closest('.output');\n",
-       "if (outputEl) {{\n",
-       "    x.observe(outputEl, {childList: true});\n",
-       "}}\n",
-       "\n",
-       "                        })\n",
-       "                };\n",
-       "                });\n",
-       "            </script>\n",
-       "        </div>"
-      ]
+      }
      },
      "metadata": {},
      "output_type": "display_data"
@@ -6979,9 +6887,16 @@
     "Fortunately, both these cases are arguably biologically infeasible. As a result, we may stabilise the optimisation by limiting the search space to biologically feasible parameter values. We choose to limit the model parameters to values in $[10^{-3}, 10^3]$. Those parameter ranges should be sufficient, unless we have chosen vastly inappropriate units for the model parameters."
    ]
   },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Run optimisation"
+   ]
+  },
   {
    "cell_type": "code",
-   "execution_count": 6,
+   "execution_count": 4,
    "metadata": {
     "tags": []
    },
@@ -6989,7 +6904,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "7e67070ae7e847c4a73d9b65cbb03977",
+       "model_id": "dea370f1e6a147518bda9aaeb9cdeb34",
        "version_major": 2,
        "version_minor": 0
       },
@@ -7015,7 +6930,6 @@
     "\n",
     "import os\n",
     "\n",
-    "import myokit\n",
     "import numpy as np\n",
     "import pandas as pd\n",
     "import pints\n",
@@ -7028,81 +6942,52 @@
     "n_runs = 10\n",
     "\n",
     "# Import data\n",
-    "# Get path of current working directory\n",
     "path = os.getcwd()\n",
-    "\n",
-    "# Import LXF A677 control growth data\n",
     "data = pd.read_csv(path + '/data/lxf_control_growth.csv')\n",
     "\n",
     "# Define model\n",
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - Eigenmann et. al.')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=False)\n",
     "\n",
-    "# Define container for the structural model estimates\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
+    "# Define initial parameters\n",
     "n_mice = len(data['#ID'].unique())\n",
-    "n_parameters = 3\n",
-    "parameters_constrained = np.empty(shape=(n_mice, n_runs, n_parameters))\n",
-    "\n",
-    "# Define container for the objective function score for the optimised parameters\n",
-    "scores_constrained = np.empty(shape=(n_mice, n_runs))\n",
-    "\n",
-    "# Define random starting points over many orders of magnitude\n",
-    "# Shape = (n_runs, n_parameters)\n",
+    "n_parameters = model.n_parameters()\n",
     "initial_parameters = np.random.uniform(low=1E-3, high=1E3, size=(n_runs, n_parameters))\n",
     "\n",
-    "# Find mouse parameters for LXF A677 population\n",
+    "# Create boundaries to biologically relevant values\n",
+    "boundaries = pints.RectangularBoundaries(\n",
+    "    lower=[1E-3] * n_parameters, upper=[1E3] * n_parameters)\n",
+    "\n",
+    "# Find parameters for each mouse\n",
+    "parameters_constrained = []\n",
+    "scores_constrained = []\n",
     "mouse_ids = data['#ID'].unique()\n",
     "for index, mouse_id in enumerate(tqdm(mouse_ids)):\n",
-    "    # Create mask for mouse with specfied ID\n",
+    "    # Get data\n",
     "    mouse_mask = data['#ID'] == mouse_id\n",
-    "\n",
-    "    # Get relevant time points\n",
     "    times = data[mouse_mask]['TIME in day'].to_numpy()\n",
-    "\n",
-    "    # Get measured tumour volumes\n",
     "    observed_volumes = data[mouse_mask]['TUMOUR VOLUME in cm^3'].to_numpy()\n",
     "\n",
     "    # Create inverse problem\n",
     "    problem = pints.SingleOutputProblem(model, times, observed_volumes)\n",
-    "\n",
-    "    # Create sum of squares error objective function\n",
     "    error = pints.SumOfSquaresError(problem)\n",
     "\n",
-    "    # Create boundaries to biologically relevant values\n",
-    "    boundary = pints.RectangularBoundaries(lower=[1E-3]*3, upper=[1E3]*3)\n",
-    "\n",
     "    # Run optimisation multiple times\n",
-    "    for run_id, initial_params in enumerate(initial_parameters):\n",
-    "        # Create optimisation controller with a CMA-ES optimiser\n",
-    "        optimiser = pints.OptimisationController(\n",
-    "            function=error,\n",
-    "            x0=initial_params,\n",
-    "            boundaries=boundary,\n",
-    "            method=pints.CMAES)\n",
-    "\n",
-    "        # Disable logging mode\n",
-    "        optimiser.set_log_to_screen(False)\n",
-    "\n",
-    "        # Parallelise optimisation\n",
-    "        optimiser.set_parallel(True)\n",
-    "\n",
-    "        # Find optimal parameters\n",
-    "        try:\n",
-    "            estimates, score = optimiser.run()\n",
-    "        except:\n",
-    "            # If inference breaks fill estimates with nan\n",
-    "            estimates = np.array([np.nan, np.nan, np.nan])\n",
-    "            score = np.nan\n",
-    "\n",
-    "        # Save estimates and score\n",
-    "        parameters_constrained[index, run_id, :] = estimates\n",
-    "        scores_constrained[index, run_id] = score"
+    "    p, s = pkpd.optimise(error, pints.CMAES, initial_parameters, n_runs, boundaries)\n",
+    "    parameters_constrained += [p]\n",
+    "    scores_constrained += [s]"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Visualise results"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 7,
+   "execution_count": 5,
    "metadata": {},
    "outputs": [
     {
@@ -7132,16 +7017,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13966216061220685,
-          0.1392393802942704,
-          0.13836736611378797,
-          0.13960868049769057,
-          0.13886126665378035,
-          0.13992764090880883,
-          0.13928334890686023,
-          0.1391607453402848,
-          0.13928580285635117,
-          0.03611006342284251
+          0.13935505395382813,
+          0.13963737385483094,
+          0.14008704259638172,
+          0.13981580935811994,
+          0.037256363254957806,
+          0.13903306695162831,
+          0.13932368585789107,
+          0.13771787695782223,
+          0.1393236935494997,
+          0.13771813523019283
          ]
         },
         {
@@ -7164,16 +7049,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.27474906991370496,
-          0.2755349216266265,
-          0.27702102619211877,
-          0.27488394709325803,
-          0.27619003178241347,
-          0.27421495067210344,
-          0.2753524548402311,
-          0.2759075536536065,
-          0.27535872120902566,
-          416.9060819011438
+          0.27588951159077624,
+          0.27481551752634914,
+          0.2740177324866491,
+          0.27451191216232473,
+          120.46463415192612,
+          0.27587885530829226,
+          0.2754108925971648,
+          0.2849531249071333,
+          0.27541090002266577,
+          0.2849525193463833
          ]
         },
         {
@@ -7196,16 +7081,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13098853526598717,
-          0.1309623373437996,
-          0.13087727563800086,
-          0.1309823887941901,
-          0.1309133960497785,
-          0.13099941247255079,
-          0.13094213488551334,
-          0.13088153330740096,
-          0.1309341708122139,
-          0.1008453067410279
+          0.1307897409657771,
+          0.13098778833642818,
+          0.1310252588418374,
+          0.13100461734366428,
+          0.10083618829480245,
+          0.13094021459985328,
+          0.13096883362529194,
+          0.12961969330643086,
+          0.13096884371071482,
+          0.12961965719455246
          ]
         },
         {
@@ -7228,16 +7113,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.03186099085413183,
-          0.03186037690739698,
-          0.031863699228153644,
-          0.03186053682361942,
-          0.03186118850917417,
-          0.03186275149380063,
-          0.031861995809769665,
-          0.031882951942965046,
-          0.031862189085071664,
-          0.06886294119010507
+          0.031890954146104544,
+          0.03186072494564946,
+          0.03186209259839052,
+          0.03186102020743704,
+          0.06864805097030921,
+          0.03186076599835884,
+          0.03186018809085646,
+          0.0319027316597978,
+          0.03186018808966165,
+          0.03190273166302251
          ]
         },
         {
@@ -7260,16 +7145,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0747233586765469,
-          0.05751966313587425,
-          0.07394615305217886,
-          0.07479931767238668,
-          0.05752213836184534,
-          0.05752211828818429,
-          0.0747993233659156,
-          0.0575282379826756,
-          0.05752672061232226,
-          0.05752669891116449
+          0.0575221136990424,
+          0.05752213474144602,
+          0.05752214654649604,
+          0.07443659183355741,
+          0.05754165006670578,
+          0.0575221215425754,
+          0.05752670037933763,
+          0.05752213313321655,
+          0.07455463780285884,
+          0.07414837837420638
          ]
         },
         {
@@ -7292,16 +7177,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.16759124179778218,
-          371.4695462444174,
-          0.1758293662182364,
-          0.16503508151799906,
-          999.9999981716551,
-          999.9999989743171,
-          0.16503507183843868,
-          391.2108102295771,
-          390.847925779114,
-          390.84809514389684
+          999.9999995636041,
+          999.9999998739415,
+          999.9999996613873,
+          0.1694008725631711,
+          173.33092003605603,
+          999.9999998728312,
+          390.848046624404,
+          999.9999999008324,
+          0.16791130155112333,
+          0.17015066858873473
          ]
         },
         {
@@ -7324,16 +7209,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.02030990253660721,
-          0.01644047528602439,
-          0.02010694168931012,
-          0.020388810801847727,
-          0.016438528248607545,
-          0.01643852888440849,
-          0.020388811083384615,
-          0.016439783763886048,
-          0.01643969737629382,
-          0.01643969928807421
+          0.016438529015588725,
+          0.016438528594943866,
+          0.016438527514565746,
+          0.020274564031928212,
+          0.016441179366034998,
+          0.016438529224618265,
+          0.01643969747976317,
+          0.016438528676105096,
+          0.02031387199557154,
+          0.02028868966387582
          ]
         },
         {
@@ -7356,16 +7241,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.007448614329760227,
-          0.008274380260283178,
-          0.007453764081890851,
-          0.007450327517824409,
-          0.008274993986076604,
-          0.008274993986077806,
-          0.007450327517830355,
-          0.008274292394539045,
-          0.008274291669364043,
-          0.008274291669371889
+          0.008274993986079376,
+          0.008274993986077542,
+          0.008274993986078106,
+          0.00744856391338471,
+          0.008273018389451336,
+          0.008274993986076767,
+          0.008274291669371336,
+          0.008274993986076765,
+          0.007448217820389367,
+          0.007449260686480994
          ]
         },
         {
@@ -7388,16 +7273,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0031732202080404634,
-          0.0011293785776255974,
-          0.0011927974520289915,
-          0.0012908500500536527,
-          0.0012145413634658984,
-          0.0022811824646846047,
-          0.0031755797739056505,
-          0.002360237962814391,
-          0.0012404175081562909,
-          0.0010239873234758623
+          0.0013779397146668573,
+          0.0010957102960441913,
+          0.0014346085004211084,
+          0.22106914891618146,
+          0.001026640869707422,
+          0.0013465357673668671,
+          0.0013240222469974028,
+          0.0013659191835265856,
+          0.22106913594324812,
+          0.0014472787881759648
          ]
         },
         {
@@ -7420,16 +7305,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.883506692688003,
-          112.7606396614649,
-          914.0209765263542,
-          184.44287544467826,
-          775.5802930684362,
-          450.09933280944705,
-          304.0612399792039,
-          386.53721949529864,
-          778.7428503581883,
-          674.5249532066144
+          890.7103334612502,
+          426.6464728540896,
+          98.85977499018533,
+          0.055534238268137415,
+          128.3361489579584,
+          938.3732944241475,
+          996.2195932438187,
+          979.683364707877,
+          0.055534239957682446,
+          842.6831835123096
          ]
         },
         {
@@ -7452,16 +7337,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.11389837134358236,
-          0.0885587961720969,
-          0.08844478318430994,
-          0.08818413325540483,
-          0.08841080263713814,
-          0.08829515820975724,
-          0.08819794352853638,
-          0.0885396872445609,
-          0.08839933449580564,
-          0.08831789373512056
+          0.08843780413025851,
+          0.08838909855646739,
+          0.08846339446062626,
+          999.9999999289612,
+          0.08848945684049492,
+          0.08845143099663984,
+          0.08831724538284547,
+          0.08828501305207816,
+          999.999999969879,
+          0.08837801655080993
          ]
         },
         {
@@ -7484,16 +7369,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.48790217253038703,
-          0.5364128820635037,
-          0.5374798476536043,
-          0.5365796495310895,
-          0.5376537368704075,
-          0.5375986423278539,
-          0.5370769353560377,
-          0.5371397637246197,
-          0.5375048729257421,
-          0.5374916813796884
+          0.5376131431049419,
+          0.53716288367012,
+          0.536069314844526,
+          0.09931836749904382,
+          0.5365038059936609,
+          0.5369608611538081,
+          0.537306730819598,
+          0.5371760359673853,
+          0.09931836749904085,
+          0.5370272216613975
          ]
         },
         {
@@ -7516,16 +7401,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14808159002416124,
-          0.1482708001474232,
-          0.14818806791314298,
-          0.14907619063506214,
-          0.14827531986111353,
-          0.01843758758024032,
-          0.018941442043256845,
-          0.01894136911833049,
-          0.018743096311483555,
-          0.1489615896007308
+          0.14902203516289222,
+          0.1477233035034868,
+          0.01894166999297574,
+          0.1480868521767487,
+          0.1472805225493845,
+          0.14896169321328717,
+          0.14894698838039028,
+          0.14795774349718296,
+          0.1490070931663647,
+          0.14800795226453778
          ]
         },
         {
@@ -7548,16 +7433,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0548105873563145,
-          0.05479295693397931,
-          0.054980510931169846,
-          0.054247395169595675,
-          0.05477510854885026,
-          275.47936857190064,
-          212.9832334569831,
-          212.98402470913192,
-          134.2240552030831,
-          0.054271403208235286
+          0.05425475549200409,
+          0.05525831823415531,
+          212.9814291070331,
+          0.0548182253343315,
+          0.05500504176642491,
+          0.05427191947909699,
+          0.05427338761698994,
+          0.05485298079776067,
+          0.0542647775261452,
+          0.05485444219555066
          ]
         },
         {
@@ -7580,16 +7465,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12673949353452177,
-          0.12679290647957137,
-          0.12560045477117038,
-          0.12879291385414454,
-          0.12673145232760824,
-          0.040816311410503826,
-          0.04079040019802879,
-          0.04079044117387545,
-          0.04081422556890785,
-          0.12880177145989166
+          0.12881202346148,
+          0.12469224624968633,
+          0.04079039713330935,
+          0.12657304527206026,
+          0.12649477670795206,
+          0.12880179211271847,
+          0.1287936030932423,
+          0.1266090791211185,
+          0.12876885701575055,
+          0.12681066653653564
          ]
         },
         {
@@ -7612,16 +7497,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.04018066150107346,
-          0.04018245540309769,
-          0.04020767769466682,
-          0.04018493331841817,
-          0.04018070584845965,
-          0.10936770572125135,
-          0.1093418619042564,
-          0.10934186190421989,
-          0.10931912909421844,
-          0.04018491076716884
+          0.04018460389056981,
+          0.04021197460216726,
+          0.10934186190158193,
+          0.04018317060700636,
+          0.04019172901184017,
+          0.0401846596428113,
+          0.04018481601245771,
+          0.04018220057192293,
+          0.04018606705684341,
+          0.04018360053059638
          ]
         },
         {
@@ -7644,16 +7529,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0010000000000522254,
-          0.0013032538334112921,
-          0.0010015221184997455,
-          0.08430035958650012,
-          0.0010000000387958845,
-          0.0010007887991584593,
-          0.0010000000080855505,
-          0.0011179021506439674,
-          0.0010000008375058583,
-          0.0010030902852179585
+          0.001000749384650692,
+          0.0010833820355571888,
+          0.0010348488279949355,
+          0.0011191772605621225,
+          0.08430034289529531,
+          0.0010000000135889859,
+          0.001001481027523057,
+          0.0010000000070512643,
+          0.0010003773580725976,
+          0.0011819490863601606
          ]
         },
         {
@@ -7676,16 +7561,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          739.6469933019176,
-          839.9657439711111,
-          818.6645541049484,
-          0.05412914831883828,
-          232.52683486194329,
-          709.1953841788362,
-          391.6714922852528,
-          696.722687810695,
-          378.7845863608038,
-          428.8188598224306
+          263.0517398810738,
+          293.6674227314946,
+          601.9026084377575,
+          869.0729266312336,
+          0.05412915004349788,
+          981.6038324318924,
+          717.8089373843462,
+          935.562686080941,
+          578.6117697789267,
+          538.8554002647442
          ]
         },
         {
@@ -7708,16 +7593,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05009367023389761,
-          0.04997320177296987,
-          0.05001323227051691,
-          999.9999999581072,
-          0.050120131643706295,
-          0.050085374783289616,
-          0.05010371715771321,
-          0.049927059322740545,
-          0.05010394532891427,
-          0.050086619792195336
+          0.05010180966554809,
+          0.050109972881741814,
+          0.05008776235051867,
+          0.05005385805937668,
+          999.9999999047621,
+          0.050091279921610485,
+          0.050096683840762775,
+          0.050090702865187686,
+          0.05009957567680984,
+          0.049863075820768564
          ]
         },
         {
@@ -7740,16 +7625,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          1.2720027721759142,
-          1.270156851597544,
-          1.270771610236052,
-          0.14589083590909754,
-          1.2712397765264816,
-          1.2719430812909962,
-          1.2717042191345682,
-          1.2716968978951702,
-          1.2715157571486697,
-          1.2714407277217974
+          1.270624773456327,
+          1.2705322889942572,
+          1.2712064011001436,
+          1.2717273130321431,
+          0.14589083590912388,
+          1.2720728717500418,
+          1.2718970304616792,
+          1.2720651549951274,
+          1.2713628850922642,
+          1.2717573673132305
          ]
         },
         {
@@ -7772,16 +7657,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0066680830604563274,
-          0.007626203311134001,
-          0.006598418793654343,
-          0.00352566697401242,
-          0.007603108122784804,
-          0.006265311153895958,
-          0.006320007896389605,
-          0.006807261959264175,
-          0.008589499064041172,
-          0.008048143319760882
+          0.007054762572436944,
+          0.0085883449079769,
+          0.008589232446535802,
+          0.007670809466458013,
+          0.010268213452617265,
+          0.008093267892210756,
+          0.002148536146865326,
+          0.007385211112167251,
+          0.008697630261301196,
+          0.007368563441526568
          ]
         },
         {
@@ -7804,16 +7689,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          645.2194850333956,
-          805.1484001810633,
-          112.16223732775728,
-          33.792469355356886,
-          803.8106559962399,
-          291.79657967933076,
-          297.82540978716725,
-          639.6015029566794,
-          838.6809430397625,
-          576.1808812015785
+          874.5361847845901,
+          838.735665407371,
+          838.6934180819704,
+          799.5812125317027,
+          265.3033559108349,
+          144.19252194305494,
+          996.8314128939405,
+          95.78695214123051,
+          791.1148180236484,
+          333.7397898646138
          ]
         },
         {
@@ -7836,16 +7721,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08039764266210023,
-          0.08035564343102126,
-          0.08048725987356004,
-          0.08099375094123074,
-          0.08033200913989702,
-          0.08047008920175813,
-          0.08049624977002168,
-          0.0803901054193891,
-          0.08028724647431351,
-          0.08032236701141796
+          0.08037960168457481,
+          0.08028731527068644,
+          0.08028724716787261,
+          0.0803403029312739,
+          0.080228548662269,
+          0.08032036593764526,
+          0.08059299627362027,
+          0.08040617491550975,
+          0.080281609894648,
+          0.08037516003143211
          ]
         },
         {
@@ -7868,16 +7753,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.29201217448716466,
-          0.29201877867655146,
-          0.2916297843888823,
-          0.2908007396573443,
-          0.29201754557209075,
-          0.29175054383693677,
-          0.2919357286697756,
-          0.2920120856632118,
-          0.29204046647191717,
-          0.2920129943671273
+          0.29200811932934617,
+          0.29204046647383264,
+          0.2920404664699568,
+          0.29201873033797116,
+          0.29180439825423377,
+          0.2916652560697739,
+          0.2920186269683279,
+          0.29126361246789656,
+          0.2920397421257895,
+          0.2918911931329787
          ]
         },
         {
@@ -7900,16 +7785,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12332980885229608,
-          0.1233297566723445,
-          0.06622632846484926,
-          0.12331374362733591,
-          0.0662261913580372,
-          0.06622607782258878,
-          0.06622631982818493,
-          0.06624766942366576,
-          0.06622631476152321,
-          0.06623468506388429
+          0.06622903776651948,
+          0.12332982426371533,
+          0.1233297810612439,
+          0.06624796730801466,
+          0.12380947433915848,
+          0.12380948022534943,
+          0.06622616545953301,
+          0.06622618396604579,
+          0.06622909345290753,
+          0.06624788074970805
          ]
         },
         {
@@ -7932,16 +7817,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.043521165423161014,
-          0.04352117716411921,
-          448.0129961841942,
-          0.04353364124760715,
-          448.01387017662523,
-          448.01464268789914,
-          448.01306587204675,
-          198.19658227322842,
-          448.01305039147,
-          999.9999999995733
+          913.0079368637086,
+          0.04352116067337324,
+          0.04352117067186325,
+          198.19557088444563,
+          0.04303161895822001,
+          0.04303161550930587,
+          448.01407649930144,
+          448.0140025663064,
+          898.2558075108308,
+          198.19588869560334
          ]
         },
         {
@@ -7964,16 +7849,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07139562038791057,
-          0.07139561035585278,
-          0.02129778981533687,
-          0.07139938037040551,
-          0.021297794098721207,
-          0.021297799943080942,
-          0.021297790616453826,
-          0.021299347818100715,
-          0.02129778921750745,
-          0.02129590298718898
+          0.021296363232295397,
+          0.07139562125478481,
+          0.07139561339172776,
+          0.021299325072429216,
+          0.07299522041207361,
+          0.07299521752859793,
+          0.02129779713436319,
+          0.0212977985703406,
+          0.021296385906548355,
+          0.021299333129192723
          ]
         },
         {
@@ -7996,16 +7881,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0029160191458677846,
-          0.0029160191458441048,
-          0.018940825435373933,
-          0.002916110860053968,
-          0.01894082543524878,
-          0.01894082543530149,
-          0.01894082543535437,
-          0.018933971138382834,
-          0.018940825435242826,
-          0.018944891422847214
+          0.018945356293642635,
+          0.0029160191458744975,
+          0.00291601914585881,
+          0.018933971137737544,
+          0.0029152929592302468,
+          0.0029152929591584956,
+          0.018940825435214356,
+          0.018940825435374106,
+          0.018945359763404845,
+          0.01893397113832238
          ]
         },
         {
@@ -8028,16 +7913,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08704785908155321,
-          0.02693928100093285,
-          0.02696059482858459,
-          0.026939360712696533,
-          0.026906033530011936,
-          0.08704783007141144,
-          0.0269156738488493,
-          0.026960673305456605,
-          0.026907938834864486,
-          0.08704781984451501
+          0.026939314860547275,
+          0.026939266576853083,
+          0.026939300665792063,
+          0.08704782723654708,
+          0.026906081506686223,
+          0.08704781784389791,
+          0.026939249810771903,
+          0.026960583539568587,
+          0.026939474092701764,
+          0.08704783199312695
          ]
         },
         {
@@ -8060,16 +7945,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.036172148433533044,
-          830.5898170854148,
-          382.6804090026202,
-          830.5876523278391,
-          721.0530669331378,
-          0.03617215567359481,
-          669.0106436507664,
-          382.6793280276247,
-          699.3797421418218,
-          0.036172157079454995
+          830.5888769280831,
+          830.5903038628429,
+          830.5892757963651,
+          0.03617215555552812,
+          721.0389954529852,
+          0.03617215818534085,
+          830.5907780896384,
+          382.6805127953819,
+          830.5843733196674,
+          0.036172154244504505
          ]
         },
         {
@@ -8092,16 +7977,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1932584388385975,
-          0.017329880551834216,
-          0.017330217422589743,
-          0.017329877937612488,
-          0.017332443099485124,
-          0.193258414911328,
-          0.01733198937727566,
-          0.0173302097136723,
-          0.01733274153510398,
-          0.19325840031614364
+          0.017329877910035277,
+          0.017329880988553367,
+          0.017329878472012016,
+          0.19325840823788415,
+          0.017332439672579327,
+          0.19325840184737064,
+          0.01732988163601599,
+          0.017330216561304745,
+          0.017329872420053752,
+          0.1932584114860439
          ]
         },
         {
@@ -8124,16 +8009,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0023155933408021707,
-          0.022870488494119837,
-          0.02286578563108038,
-          0.022870488494257518,
-          0.02286980718804213,
-          0.0023155933407833936,
-          0.022869160047657662,
-          0.0228657856314402,
-          0.022870055032630378,
-          0.002315593340781636
+          0.02287048849421273,
+          0.022870488494202677,
+          0.022870488494197698,
+          0.002315593340780917,
+          0.02286980718823755,
+          0.0023155933407809854,
+          0.02287048849421147,
+          0.02286578563132019,
+          0.022870488494385832,
+          0.0023155933407819876
          ]
         }
        ],
@@ -9314,20 +9199,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"265b3862-eea6-4b8b-ae4c-bfd9c3850530\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"7d486b6a-d1fc-4e3f-a76d-f77c646920ab\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"265b3862-eea6-4b8b-ae4c-bfd9c3850530\")) {\n",
+       "                if (document.getElementById(\"7d486b6a-d1fc-4e3f-a76d-f77c646920ab\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        '265b3862-eea6-4b8b-ae4c-bfd9c3850530',\n",
-       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13966216061220685, 0.1392393802942704, 0.13836736611378797, 0.13960868049769057, 0.13886126665378035, 0.13992764090880883, 0.13928334890686023, 0.1391607453402848, 0.13928580285635117, 0.03611006342284251]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.27474906991370496, 0.2755349216266265, 0.27702102619211877, 0.27488394709325803, 0.27619003178241347, 0.27421495067210344, 0.2753524548402311, 0.2759075536536065, 0.27535872120902566, 416.9060819011438]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13098853526598717, 0.1309623373437996, 0.13087727563800086, 0.1309823887941901, 0.1309133960497785, 0.13099941247255079, 0.13094213488551334, 0.13088153330740096, 0.1309341708122139, 0.1008453067410279]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.03186099085413183, 0.03186037690739698, 0.031863699228153644, 0.03186053682361942, 0.03186118850917417, 0.03186275149380063, 0.031861995809769665, 0.031882951942965046, 0.031862189085071664, 0.06886294119010507]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0747233586765469, 0.05751966313587425, 0.07394615305217886, 0.07479931767238668, 0.05752213836184534, 0.05752211828818429, 0.0747993233659156, 0.0575282379826756, 0.05752672061232226, 0.05752669891116449]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.16759124179778218, 371.4695462444174, 0.1758293662182364, 0.16503508151799906, 999.9999981716551, 999.9999989743171, 0.16503507183843868, 391.2108102295771, 390.847925779114, 390.84809514389684]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.02030990253660721, 0.01644047528602439, 0.02010694168931012, 0.020388810801847727, 0.016438528248607545, 0.01643852888440849, 0.020388811083384615, 0.016439783763886048, 0.01643969737629382, 0.01643969928807421]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.007448614329760227, 0.008274380260283178, 0.007453764081890851, 0.007450327517824409, 0.008274993986076604, 0.008274993986077806, 0.007450327517830355, 0.008274292394539045, 0.008274291669364043, 0.008274291669371889]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0031732202080404634, 0.0011293785776255974, 0.0011927974520289915, 0.0012908500500536527, 0.0012145413634658984, 0.0022811824646846047, 0.0031755797739056505, 0.002360237962814391, 0.0012404175081562909, 0.0010239873234758623]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.883506692688003, 112.7606396614649, 914.0209765263542, 184.44287544467826, 775.5802930684362, 450.09933280944705, 304.0612399792039, 386.53721949529864, 778.7428503581883, 674.5249532066144]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.11389837134358236, 0.0885587961720969, 0.08844478318430994, 0.08818413325540483, 0.08841080263713814, 0.08829515820975724, 0.08819794352853638, 0.0885396872445609, 0.08839933449580564, 0.08831789373512056]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.48790217253038703, 0.5364128820635037, 0.5374798476536043, 0.5365796495310895, 0.5376537368704075, 0.5375986423278539, 0.5370769353560377, 0.5371397637246197, 0.5375048729257421, 0.5374916813796884]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14808159002416124, 0.1482708001474232, 0.14818806791314298, 0.14907619063506214, 0.14827531986111353, 0.01843758758024032, 0.018941442043256845, 0.01894136911833049, 0.018743096311483555, 0.1489615896007308]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0548105873563145, 0.05479295693397931, 0.054980510931169846, 0.054247395169595675, 0.05477510854885026, 275.47936857190064, 212.9832334569831, 212.98402470913192, 134.2240552030831, 0.054271403208235286]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12673949353452177, 0.12679290647957137, 0.12560045477117038, 0.12879291385414454, 0.12673145232760824, 0.040816311410503826, 0.04079040019802879, 0.04079044117387545, 0.04081422556890785, 0.12880177145989166]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04018066150107346, 0.04018245540309769, 0.04020767769466682, 0.04018493331841817, 0.04018070584845965, 0.10936770572125135, 0.1093418619042564, 0.10934186190421989, 0.10931912909421844, 0.04018491076716884]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0010000000000522254, 0.0013032538334112921, 0.0010015221184997455, 0.08430035958650012, 0.0010000000387958845, 0.0010007887991584593, 0.0010000000080855505, 0.0011179021506439674, 0.0010000008375058583, 0.0010030902852179585]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [739.6469933019176, 839.9657439711111, 818.6645541049484, 0.05412914831883828, 232.52683486194329, 709.1953841788362, 391.6714922852528, 696.722687810695, 378.7845863608038, 428.8188598224306]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05009367023389761, 0.04997320177296987, 0.05001323227051691, 999.9999999581072, 0.050120131643706295, 0.050085374783289616, 0.05010371715771321, 0.049927059322740545, 0.05010394532891427, 0.050086619792195336]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.2720027721759142, 1.270156851597544, 1.270771610236052, 0.14589083590909754, 1.2712397765264816, 1.2719430812909962, 1.2717042191345682, 1.2716968978951702, 1.2715157571486697, 1.2714407277217974]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0066680830604563274, 0.007626203311134001, 0.006598418793654343, 0.00352566697401242, 0.007603108122784804, 0.006265311153895958, 0.006320007896389605, 0.006807261959264175, 0.008589499064041172, 0.008048143319760882]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [645.2194850333956, 805.1484001810633, 112.16223732775728, 33.792469355356886, 803.8106559962399, 291.79657967933076, 297.82540978716725, 639.6015029566794, 838.6809430397625, 576.1808812015785]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08039764266210023, 0.08035564343102126, 0.08048725987356004, 0.08099375094123074, 0.08033200913989702, 0.08047008920175813, 0.08049624977002168, 0.0803901054193891, 0.08028724647431351, 0.08032236701141796]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.29201217448716466, 0.29201877867655146, 0.2916297843888823, 0.2908007396573443, 0.29201754557209075, 0.29175054383693677, 0.2919357286697756, 0.2920120856632118, 0.29204046647191717, 0.2920129943671273]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12332980885229608, 0.1233297566723445, 0.06622632846484926, 0.12331374362733591, 0.0662261913580372, 0.06622607782258878, 0.06622631982818493, 0.06624766942366576, 0.06622631476152321, 0.06623468506388429]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.043521165423161014, 0.04352117716411921, 448.0129961841942, 0.04353364124760715, 448.01387017662523, 448.01464268789914, 448.01306587204675, 198.19658227322842, 448.01305039147, 999.9999999995733]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07139562038791057, 0.07139561035585278, 0.02129778981533687, 0.07139938037040551, 0.021297794098721207, 0.021297799943080942, 0.021297790616453826, 0.021299347818100715, 0.02129778921750745, 0.02129590298718898]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0029160191458677846, 0.0029160191458441048, 0.018940825435373933, 0.002916110860053968, 0.01894082543524878, 0.01894082543530149, 0.01894082543535437, 0.018933971138382834, 0.018940825435242826, 0.018944891422847214]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704785908155321, 0.02693928100093285, 0.02696059482858459, 0.026939360712696533, 0.026906033530011936, 0.08704783007141144, 0.0269156738488493, 0.026960673305456605, 0.026907938834864486, 0.08704781984451501]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.036172148433533044, 830.5898170854148, 382.6804090026202, 830.5876523278391, 721.0530669331378, 0.03617215567359481, 669.0106436507664, 382.6793280276247, 699.3797421418218, 0.036172157079454995]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1932584388385975, 0.017329880551834216, 0.017330217422589743, 0.017329877937612488, 0.017332443099485124, 0.193258414911328, 0.01733198937727566, 0.0173302097136723, 0.01733274153510398, 0.19325840031614364]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0023155933408021707, 0.022870488494119837, 0.02286578563108038, 0.022870488494257518, 0.02286980718804213, 0.0023155933407833936, 0.022869160047657662, 0.0228657856314402, 0.022870055032630378, 0.002315593340781636]}],\n",
+       "                        '7d486b6a-d1fc-4e3f-a76d-f77c646920ab',\n",
+       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13935505395382813, 0.13963737385483094, 0.14008704259638172, 0.13981580935811994, 0.037256363254957806, 0.13903306695162831, 0.13932368585789107, 0.13771787695782223, 0.1393236935494997, 0.13771813523019283]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.27588951159077624, 0.27481551752634914, 0.2740177324866491, 0.27451191216232473, 120.46463415192612, 0.27587885530829226, 0.2754108925971648, 0.2849531249071333, 0.27541090002266577, 0.2849525193463833]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.1307897409657771, 0.13098778833642818, 0.1310252588418374, 0.13100461734366428, 0.10083618829480245, 0.13094021459985328, 0.13096883362529194, 0.12961969330643086, 0.13096884371071482, 0.12961965719455246]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.031890954146104544, 0.03186072494564946, 0.03186209259839052, 0.03186102020743704, 0.06864805097030921, 0.03186076599835884, 0.03186018809085646, 0.0319027316597978, 0.03186018808966165, 0.03190273166302251]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0575221136990424, 0.05752213474144602, 0.05752214654649604, 0.07443659183355741, 0.05754165006670578, 0.0575221215425754, 0.05752670037933763, 0.05752213313321655, 0.07455463780285884, 0.07414837837420638]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [999.9999995636041, 999.9999998739415, 999.9999996613873, 0.1694008725631711, 173.33092003605603, 999.9999998728312, 390.848046624404, 999.9999999008324, 0.16791130155112333, 0.17015066858873473]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.016438529015588725, 0.016438528594943866, 0.016438527514565746, 0.020274564031928212, 0.016441179366034998, 0.016438529224618265, 0.01643969747976317, 0.016438528676105096, 0.02031387199557154, 0.02028868966387582]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.008274993986079376, 0.008274993986077542, 0.008274993986078106, 0.00744856391338471, 0.008273018389451336, 0.008274993986076767, 0.008274291669371336, 0.008274993986076765, 0.007448217820389367, 0.007449260686480994]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0013779397146668573, 0.0010957102960441913, 0.0014346085004211084, 0.22106914891618146, 0.001026640869707422, 0.0013465357673668671, 0.0013240222469974028, 0.0013659191835265856, 0.22106913594324812, 0.0014472787881759648]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [890.7103334612502, 426.6464728540896, 98.85977499018533, 0.055534238268137415, 128.3361489579584, 938.3732944241475, 996.2195932438187, 979.683364707877, 0.055534239957682446, 842.6831835123096]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08843780413025851, 0.08838909855646739, 0.08846339446062626, 999.9999999289612, 0.08848945684049492, 0.08845143099663984, 0.08831724538284547, 0.08828501305207816, 999.999999969879, 0.08837801655080993]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.5376131431049419, 0.53716288367012, 0.536069314844526, 0.09931836749904382, 0.5365038059936609, 0.5369608611538081, 0.537306730819598, 0.5371760359673853, 0.09931836749904085, 0.5370272216613975]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14902203516289222, 0.1477233035034868, 0.01894166999297574, 0.1480868521767487, 0.1472805225493845, 0.14896169321328717, 0.14894698838039028, 0.14795774349718296, 0.1490070931663647, 0.14800795226453778]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05425475549200409, 0.05525831823415531, 212.9814291070331, 0.0548182253343315, 0.05500504176642491, 0.05427191947909699, 0.05427338761698994, 0.05485298079776067, 0.0542647775261452, 0.05485444219555066]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12881202346148, 0.12469224624968633, 0.04079039713330935, 0.12657304527206026, 0.12649477670795206, 0.12880179211271847, 0.1287936030932423, 0.1266090791211185, 0.12876885701575055, 0.12681066653653564]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04018460389056981, 0.04021197460216726, 0.10934186190158193, 0.04018317060700636, 0.04019172901184017, 0.0401846596428113, 0.04018481601245771, 0.04018220057192293, 0.04018606705684341, 0.04018360053059638]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.001000749384650692, 0.0010833820355571888, 0.0010348488279949355, 0.0011191772605621225, 0.08430034289529531, 0.0010000000135889859, 0.001001481027523057, 0.0010000000070512643, 0.0010003773580725976, 0.0011819490863601606]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [263.0517398810738, 293.6674227314946, 601.9026084377575, 869.0729266312336, 0.05412915004349788, 981.6038324318924, 717.8089373843462, 935.562686080941, 578.6117697789267, 538.8554002647442]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05010180966554809, 0.050109972881741814, 0.05008776235051867, 0.05005385805937668, 999.9999999047621, 0.050091279921610485, 0.050096683840762775, 0.050090702865187686, 0.05009957567680984, 0.049863075820768564]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.270624773456327, 1.2705322889942572, 1.2712064011001436, 1.2717273130321431, 0.14589083590912388, 1.2720728717500418, 1.2718970304616792, 1.2720651549951274, 1.2713628850922642, 1.2717573673132305]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.007054762572436944, 0.0085883449079769, 0.008589232446535802, 0.007670809466458013, 0.010268213452617265, 0.008093267892210756, 0.002148536146865326, 0.007385211112167251, 0.008697630261301196, 0.007368563441526568]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [874.5361847845901, 838.735665407371, 838.6934180819704, 799.5812125317027, 265.3033559108349, 144.19252194305494, 996.8314128939405, 95.78695214123051, 791.1148180236484, 333.7397898646138]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08037960168457481, 0.08028731527068644, 0.08028724716787261, 0.0803403029312739, 0.080228548662269, 0.08032036593764526, 0.08059299627362027, 0.08040617491550975, 0.080281609894648, 0.08037516003143211]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.29200811932934617, 0.29204046647383264, 0.2920404664699568, 0.29201873033797116, 0.29180439825423377, 0.2916652560697739, 0.2920186269683279, 0.29126361246789656, 0.2920397421257895, 0.2918911931329787]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.06622903776651948, 0.12332982426371533, 0.1233297810612439, 0.06624796730801466, 0.12380947433915848, 0.12380948022534943, 0.06622616545953301, 0.06622618396604579, 0.06622909345290753, 0.06624788074970805]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [913.0079368637086, 0.04352116067337324, 0.04352117067186325, 198.19557088444563, 0.04303161895822001, 0.04303161550930587, 448.01407649930144, 448.0140025663064, 898.2558075108308, 198.19588869560334]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.021296363232295397, 0.07139562125478481, 0.07139561339172776, 0.021299325072429216, 0.07299522041207361, 0.07299521752859793, 0.02129779713436319, 0.0212977985703406, 0.021296385906548355, 0.021299333129192723]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.018945356293642635, 0.0029160191458744975, 0.00291601914585881, 0.018933971137737544, 0.0029152929592302468, 0.0029152929591584956, 0.018940825435214356, 0.018940825435374106, 0.018945359763404845, 0.01893397113832238]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.026939314860547275, 0.026939266576853083, 0.026939300665792063, 0.08704782723654708, 0.026906081506686223, 0.08704781784389791, 0.026939249810771903, 0.026960583539568587, 0.026939474092701764, 0.08704783199312695]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [830.5888769280831, 830.5903038628429, 830.5892757963651, 0.03617215555552812, 721.0389954529852, 0.03617215818534085, 830.5907780896384, 382.6805127953819, 830.5843733196674, 0.036172154244504505]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.017329877910035277, 0.017329880988553367, 0.017329878472012016, 0.19325840823788415, 0.017332439672579327, 0.19325840184737064, 0.01732988163601599, 0.017330216561304745, 0.017329872420053752, 0.1932584114860439]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.02287048849421273, 0.022870488494202677, 0.022870488494197698, 0.002315593340780917, 0.02286980718823755, 0.0023155933407809854, 0.02287048849421147, 0.02286578563132019, 0.022870488494385832, 0.0023155933407819876]}],\n",
        "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"visible\": [true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 40\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 94\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 95\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 136\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 140\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 155\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false]}], \"label\": \"ID: 169\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true]}], \"label\": \"ID: 170\", \"method\": \"restyle\"}], \"direction\": \"right\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"yaxis\": {\"title\": {\"text\": \"Estimates\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('265b3862-eea6-4b8b-ae4c-bfd9c3850530');\n",
+       "var gd = document.getElementById('7d486b6a-d1fc-4e3f-a76d-f77c646920ab');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -9434,9 +9319,16 @@
     "Here, $(v_0, a_0, a_1)$ take the role of the model parameters. Arguably for this biological process a characteristic volume scale is $1\\, \\text{cm}^3$ and a characteristic time scale is $1\\, \\text{day}$.\n"
    ]
   },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Run optimisation"
+   ]
+  },
   {
    "cell_type": "code",
-   "execution_count": 8,
+   "execution_count": 7,
    "metadata": {
     "tags": []
    },
@@ -9444,7 +9336,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "21034fa6ff8140f787d26dd16f30e605",
+       "model_id": "ff7bc38dd19b42f49d105a8ab9d13e60",
        "version_major": 2,
        "version_minor": 0
       },
@@ -9472,116 +9364,77 @@
     "\n",
     "import os\n",
     "\n",
-    "import myokit\n",
     "import numpy as np\n",
     "import pandas as pd\n",
     "import pints\n",
-    "from tqdm.notebook import tqdm \n",
+    "from tqdm.notebook import tqdm\n",
     "\n",
     "import pkpd\n",
     "\n",
     "\n",
-    "# Define characteristic scales\n",
-    "characteristic_volume = 1  # in cm^3\n",
-    "characteristic_time = 1  # in day\n",
+    "# Define characteristic scales (in cm^3 and day)\n",
+    "characteristic_volume = 1\n",
+    "characteristic_time = 1\n",
     "\n",
     "# Define number of optimisation runs for each individual\n",
     "n_runs = 10\n",
     "\n",
     "# Import data\n",
-    "# Get path of current working directory\n",
     "path = os.getcwd()\n",
-    "\n",
-    "# Import LXF A677 control growth data\n",
     "data = pd.read_csv(path + '/data/lxf_control_growth.csv')\n",
     "\n",
     "# Define model\n",
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - dimensionless')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=False)\n",
     "\n",
-    "# Define container for the structural model estimates\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
+    "# Define initial parameters\n",
     "n_mice = len(data['#ID'].unique())\n",
-    "n_parameters = 3\n",
-    "transf_params_dimless = np.empty(shape=(n_mice, n_runs, n_parameters))\n",
-    "\n",
-    "# Define container for the objective function score for the optimised parameters\n",
-    "scores_dimless = np.empty(shape=(n_mice, n_runs))\n",
-    "\n",
-    "# Define random starting points over many orders of magnitude\n",
-    "# Shape = (n_runs, n_parameters)\n",
+    "n_parameters = model.n_parameters()\n",
     "initial_parameters = np.random.uniform(low=1E-3, high=1E3, size=(n_runs, n_parameters))\n",
     "\n",
-    "# Find mouse parameters for LXF A677 population\n",
+    "# Create boundaries to biologically relevant values\n",
+    "boundaries = pints.RectangularBoundaries(\n",
+    "    lower=[1E-3] * n_parameters, upper=[1E3] * n_parameters)\n",
+    "\n",
+    "# Find parameters for each mouse\n",
+    "parameters_dimless = []\n",
+    "scores_dimless = []\n",
     "mouse_ids = data['#ID'].unique()\n",
     "for index, mouse_id in enumerate(tqdm(mouse_ids)):\n",
-    "    # Create mask for mouse with specfied ID\n",
+    "    # Get data\n",
     "    mouse_mask = data['#ID'] == mouse_id\n",
-    "\n",
-    "    # Get relevant time points\n",
     "    times = data[mouse_mask]['TIME in day'].to_numpy() / characteristic_time\n",
-    "\n",
-    "    # Get measured tumour volumes\n",
-    "    observed_volumes = data[mouse_mask]['TUMOUR VOLUME in cm^3'].to_numpy() / characteristic_volume\n",
+    "    observed_volumes = data[mouse_mask]['TUMOUR VOLUME in cm^3'].to_numpy() * characteristic_volume\n",
     "\n",
     "    # Create inverse problem\n",
     "    problem = pints.SingleOutputProblem(model, times, observed_volumes)\n",
-    "\n",
-    "    # Create sum of squares error objective function\n",
     "    error = pints.SumOfSquaresError(problem)\n",
     "\n",
-    "    # Create boundaries to biologically relevant values\n",
-    "    boundary = pints.RectangularBoundaries(lower=[1E-3]*3, upper=[1E3]*3)\n",
-    "\n",
     "    # Run optimisation multiple times\n",
-    "    for run_id, initial_params in enumerate(initial_parameters):\n",
-    "        # Create optimisation controller with a CMA-ES optimiser\n",
-    "        optimiser = pints.OptimisationController(\n",
-    "            function=error,\n",
-    "            x0=initial_params,\n",
-    "            boundaries=boundary,\n",
-    "            method=pints.CMAES)\n",
-    "\n",
-    "        # Disable logging mode\n",
-    "        optimiser.set_log_to_screen(False)\n",
-    "\n",
-    "        # Parallelise optimisation\n",
-    "        optimiser.set_parallel(True)\n",
-    "\n",
-    "        # Find optimal parameters\n",
-    "        try:\n",
-    "            estimates, score = optimiser.run()\n",
-    "        except:\n",
-    "            # If inference breaks fill estimates with nan\n",
-    "            estimates = np.array([np.nan, np.nan, np.nan])\n",
-    "            score = np.nan\n",
-    "\n",
-    "        # Save estimates and score\n",
-    "        transf_params_dimless[index, run_id, :] = estimates\n",
-    "        scores_dimless[index, run_id] = score\n",
+    "    p, s = pkpd.optimise(error, pints.CMAES, initial_parameters, n_runs, boundaries)\n",
+    "    parameters_dimless += [p]\n",
+    "    scores_dimless += [s]\n",
     "\n",
     "# Transform dimensionless parameters back to biological parameters.\n",
-    "# Initialise container for backtransformed paramters\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
-    "parameters_dimless = np.empty(shape=transf_params_dimless.shape)\n",
+    "# Initialise container for backtransformed parameters\n",
+    "parameters_dimless = np.asarray(parameters_dimless)\n",
+    "p = parameters_dimless.copy()\n",
     "\n",
     "# Transform initial volumes\n",
-    "parameters_dimless[:, :, 0] = transf_params_dimless[:, :, 0] * characteristic_volume\n",
+    "parameters_dimless[:, :, 0] = p[:, :, 0] * characteristic_volume\n",
     "\n",
     "# Transform exponential growth rate\n",
-    "# lambda_0 = a_1 / a_0 /t^c\n",
-    "parameters_dimless[:, :, 1] = \\\n",
-    "    transf_params_dimless[:, :, 2] / 2 / transf_params_dimless[:, :, 1] / characteristic_time\n",
+    "# lambda_0 = a_1 / 2a_0 /t^c\n",
+    "parameters_dimless[:, :, 1] = p[:, :, 2] / 2 / p[:, :, 1] / characteristic_time\n",
     "\n",
     "# Transform linear growth rate\n",
     "# lambda_1 = a_1 / a_0 /t^c\n",
-    "parameters_dimless[:, :, 2] = \\\n",
-    "    transf_params_dimless[:, :, 2] * characteristic_volume / characteristic_time"
+    "parameters_dimless[:, :, 2] = p[:, :, 2] * characteristic_volume / characteristic_time"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 9,
+   "execution_count": 8,
    "metadata": {},
    "outputs": [
     {
@@ -9611,16 +9464,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.1407679898909402,
-          0.13937476631538367,
-          0.13977300095109937,
-          0.1395659679601429,
-          0.13925387235412634,
-          0.1397899944007349,
-          0.14048550401447726,
-          0.13917164507007296,
-          0.13932357844085694,
-          0.13934122196582824
+          0.13918719165099708,
+          0.14055115195712864,
+          0.13932395387017527,
+          0.13943859454630717,
+          0.13979298016345132,
+          0.13902481164586789,
+          0.1386972899219595,
+          0.13903615339402747,
+          0.13916046682005412,
+          0.1394914121331874
          ]
         },
         {
@@ -9643,16 +9496,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.27283606582229986,
-          0.27532844139206664,
-          0.2746038271933532,
-          0.27497034901341977,
-          0.2755281153889101,
-          0.2745172825185839,
-          0.27319145743215323,
-          0.27563824157266664,
-          0.275411081891578,
-          0.27527417548717376
+          0.27564483940463885,
+          0.2731491955393398,
+          0.2754104065201399,
+          0.27511443456742835,
+          0.2744336140315837,
+          0.2759827064804965,
+          0.2764772283947938,
+          0.2758600699375978,
+          0.27590785909120547,
+          0.2750283532537084
          ]
         },
         {
@@ -9675,16 +9528,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13106897509888263,
-          0.13100574650052207,
-          0.13100251279614267,
-          0.13099790348980117,
-          0.13097455745634579,
-          0.13098053386761524,
-          0.13102217174016928,
-          0.1309845176109183,
-          0.13096882466506812,
-          0.13096339160830717
+          0.1309855719413908,
+          0.13102688288099468,
+          0.13096885082260643,
+          0.13095848417226005,
+          0.13095003928756968,
+          0.13097293759549078,
+          0.13090766243972243,
+          0.13092460822035862,
+          0.13088154888469347,
+          0.13098251490347287
          ]
         },
         {
@@ -9707,16 +9560,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.03186628502705805,
-          0.031861225728881115,
-          0.03186079563743918,
-          0.03186055486488268,
-          0.0318604446508444,
-          0.03186176123880478,
-          0.031867534098104944,
-          0.031861103591720855,
-          0.031860188091619036,
-          0.031861143593183566
+          0.031861044387893,
+          0.03186657886674443,
+          0.03186018809268653,
+          0.03186132366057374,
+          0.03186510872583087,
+          0.03186130971115906,
+          0.03186164765003843,
+          0.03186112279970249,
+          0.03188295194173178,
+          0.031860910862734224
          ]
         },
         {
@@ -9739,16 +9592,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07479928377326645,
-          0.07479931524986619,
-          0.07477543038886798,
-          0.07443693119031498,
-          0.07479928758490023,
-          0.07455485161561286,
-          0.0745542193197406,
-          0.07479929460002896,
-          0.07484129954693211,
-          0.07454904261356884
+          0.07443659963620419,
+          0.07462314826271575,
+          0.07479932076333078,
+          0.07479927771253134,
+          0.07454892839008512,
+          0.0747992621013509,
+          0.07479928905831912,
+          0.07455488705752467,
+          0.07454902241485084,
+          0.0747993112332315
          ]
         },
         {
@@ -9771,16 +9624,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1650351778227765,
-          0.16503508871520403,
-          0.16744134137100591,
-          0.16940011860301396,
-          0.16503516135165144,
-          0.1679110357361122,
-          0.1679124158778232,
-          0.1650351446869388,
-          0.16489787851452528,
-          0.1679842598223166
+          0.1694008172125861,
+          0.167900555995953,
+          0.16503508120383462,
+          0.1650351812152207,
+          0.1679844731200665,
+          0.16503521542192892,
+          0.16503515762648371,
+          0.16791092099838076,
+          0.16798428265869367,
+          0.16503509248217985
          ]
         },
         {
@@ -9803,16 +9656,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.02038881391357691,
-          0.020388811065620183,
-          0.020314885322984578,
-          0.020274561393839017,
-          0.02038881287165887,
-          0.020313894523142566,
-          0.02031389981101447,
-          0.020388812624245935,
-          0.020394733735788102,
-          0.02031192008278776
+          0.020274559389377386,
+          0.02032151694361342,
+          0.020388811566643746,
+          0.02038881276825506,
+          0.020311916648156937,
+          0.020388812947371972,
+          0.020388812794037803,
+          0.020313889720233232,
+          0.020311917622961143,
+          0.020388810492726818
          ]
         },
         {
@@ -9835,16 +9688,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.007450327517825344,
-          0.00745032751782992,
-          0.007448891639474378,
-          0.007448563912800039,
-          0.007450327517830336,
-          0.0074482178222304435,
-          0.007448217820299516,
-          0.007450327517815607,
-          0.007450449935167196,
-          0.0074482325215940075
+          0.007448563913034786,
+          0.007448853502447956,
+          0.007450327517833169,
+          0.007450327517830882,
+          0.0074482325209846425,
+          0.007450327517829625,
+          0.007450327517832178,
+          0.007448217820324642,
+          0.00744823252150573,
+          0.0074503275178434015
          ]
         },
         {
@@ -9867,16 +9720,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.2209043664932811,
-          0.2209043718094108,
-          0.22090437981791836,
-          0.2209043814829003,
-          0.22090439442144383,
-          0.22090437020411036,
-          0.22090438138452972,
-          0.22090438274169577,
-          0.2209043963004837,
-          0.2209043778913313
+          0.2209043946194997,
+          0.22090438355020525,
+          0.22090437429756848,
+          0.22090437788921907,
+          0.22090437786125117,
+          0.22090436669496116,
+          0.22090437224142262,
+          0.2209043669029539,
+          0.22090437393227635,
+          0.22090438692679815
          ]
         },
         {
@@ -9899,16 +9752,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05559246627706614,
-          0.05559246557183007,
-          0.05559246507974724,
-          0.05559246461297198,
-          0.05559246263832922,
-          0.05559246596714391,
-          0.05559246468762012,
-          0.05559246414303839,
-          0.05559246272479964,
-          0.0555924652407845
+          0.05559246315919802,
+          0.05559246422770951,
+          0.05559246592456908,
+          0.0555924649990488,
+          0.05559246491120858,
+          0.05559246670615155,
+          0.05559246599016961,
+          0.05559246618047994,
+          0.0555924655732377,
+          0.055592463237242956
          ]
         },
         {
@@ -9931,16 +9784,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          111.184932552725,
-          111.18493114365896,
-          111.18493015689738,
-          111.18492922594228,
-          111.18492527631244,
-          111.18493193428026,
-          111.18492937448522,
-          111.1849282858178,
-          111.1849254489108,
-          111.1849304815578
+          111.18492631822055,
+          111.18492845513195,
+          111.18493184886286,
+          111.18492999775414,
+          111.18492982232804,
+          111.18493341230001,
+          111.18493198032684,
+          111.18493236091,
+          111.18493114639548,
+          111.18492647443941
          ]
         },
         {
@@ -9963,16 +9816,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.09948736196066063,
-          0.09948736196065341,
-          0.09948736196065976,
-          0.09948736196065494,
-          0.09948736196066824,
-          0.09948736196065383,
-          0.09948736196065515,
-          0.09948736196066087,
-          0.09948736196066683,
-          0.09948736196064864
+          0.09948736196066517,
+          0.09948736196066746,
+          0.09948736196065906,
+          0.09948736196065563,
+          0.09948736196065783,
+          0.0994873619606613,
+          0.09948736196065448,
+          0.09948736196065806,
+          0.09948736196065261,
+          0.09948736196066187
          ]
         },
         {
@@ -9995,16 +9848,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14902261389185176,
-          0.14902105155727188,
-          0.14958448559055923,
-          0.1489959034813328,
-          0.1491188852627464,
-          0.14904529812523212,
-          0.14807785118916483,
-          0.14825679584467907,
-          0.14900479171494763,
-          0.14899595862086748
+          0.14772732140769995,
+          0.1492531105350668,
+          0.14975726679131654,
+          0.149024825824303,
+          0.14902087422209886,
+          0.14905204032236427,
+          0.1498226790272666,
+          0.1488772212919028,
+          0.1488923322261044,
+          0.14903078755899457
          ]
         },
         {
@@ -10027,16 +9880,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0542507566939512,
-          0.05426042133788948,
-          0.053774359577878954,
-          0.05426993853435017,
-          0.0542339804937269,
-          0.054251593767467604,
-          0.05479795553167865,
-          0.05477964348309504,
-          0.05425728397259722,
-          0.054265565173202725
+          0.05492887917841991,
+          0.05419604794079209,
+          0.05372151810207286,
+          0.05425644982046511,
+          0.05426047446100451,
+          0.05424562968010625,
+          0.0537164170062778,
+          0.054622660248930484,
+          0.05428778016880158,
+          0.05425130560602975
          ]
         },
         {
@@ -10059,16 +9912,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12875505172381224,
-          0.12877918951994433,
-          0.13097402363278957,
-          0.12877999106123053,
-          0.12884529749055185,
-          0.12882453549718775,
-          0.12668271600791964,
-          0.1267050691985729,
-          0.1288039197648813,
-          0.1287697527288394
+          0.12664863955029032,
+          0.12886916492355552,
+          0.13107072788242094,
+          0.12882792046502914,
+          0.12877916590622596,
+          0.1288179897255562,
+          0.13114332429186307,
+          0.12685128776653432,
+          0.12878230004914287,
+          0.12881240859434887
          ]
         },
         {
@@ -10091,16 +9944,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.040185458978753384,
-          0.04018452570624364,
-          0.040186565792226694,
-          0.04018469027460122,
-          0.040184927236240675,
-          0.04018472289075173,
-          0.040182812313316794,
-          0.040180870622448656,
-          0.0401847159948946,
-          0.0401846346930184
+          0.04018404846380736,
+          0.04018534348023183,
+          0.04018682191754251,
+          0.04018628711400928,
+          0.04018452570693834,
+          0.04018505155829083,
+          0.0401876434620321,
+          0.040184109591550186,
+          0.040185066029155975,
+          0.04018484056712653
          ]
         },
         {
@@ -10123,16 +9976,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08417659914510024,
-          0.08417665843808209,
-          0.08417668705121467,
-          0.08417662610500025,
-          0.0841766510640577,
-          0.08417664541336711,
-          0.08417663806490663,
-          0.08417665839409723,
-          0.08417664717902229,
-          0.08417666491328193
+          0.0841765936775836,
+          0.08417664540218445,
+          0.08417667879396355,
+          0.0841766445542802,
+          0.0841766510774928,
+          0.08417664170428385,
+          0.08417663881025533,
+          0.08417663255156192,
+          0.08417664424039117,
+          0.084176654761254
          ]
         },
         {
@@ -10155,16 +10008,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05418269188301627,
-          0.054182679795135656,
-          0.05418267424677904,
-          0.054182687488731826,
-          0.054182681122606574,
-          0.05418268330017553,
-          0.05418268461596464,
-          0.05418268133848667,
-          0.05418268370337028,
-          0.054182678621191034
+          0.05418269486184153,
+          0.05418268266543908,
+          0.0541826760578243,
+          0.054182683231441355,
+          0.054182681131329874,
+          0.05418268299251343,
+          0.05418268333011582,
+          0.05418268474778009,
+          0.05418268334411255,
+          0.054182681001905854
          ]
         },
         {
@@ -10187,16 +10040,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          108.36538375515293,
-          108.36535958052431,
-          108.36534847915082,
-          108.36537495581446,
-          108.36536224383929,
-          108.36536658809221,
-          108.36536922451482,
-          108.36536267212061,
-          108.365367394371,
-          108.36535723202583
+          108.36538971275093,
+          108.36536533045755,
+          108.36535210790096,
+          108.36536641689752,
+          108.36536216013873,
+          108.36536597166514,
+          108.36536665332109,
+          108.3653694579857,
+          108.36536668565707,
+          108.36536200240135
          ]
         },
         {
@@ -10219,16 +10072,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1460431583367726,
-          0.14604315833667464,
-          0.14604315833684345,
-          0.14604315833671513,
-          0.14604315833665593,
-          0.14604315833669454,
-          0.14604315833667456,
-          0.1460431583366383,
-          0.14604315833665357,
-          0.14604315833656836
+          0.14604315833668158,
+          0.14604315833665787,
+          0.1460431583368346,
+          0.14604315833671455,
+          0.1460431583368069,
+          0.14604315833669482,
+          0.14604315833677542,
+          0.14604315833675832,
+          0.1460431583366878,
+          0.14604315833655096
          ]
         },
         {
@@ -10251,16 +10104,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.13327418322427875,
-          0.13327392291528162,
-          0.13327422612284356,
-          0.1332743015139473,
-          0.13327404332908582,
-          0.13327438261588548,
-          0.13327429244301378,
-          0.13289510885504063,
-          0.1328948488468126,
-          0.133274257028495
+          0.1332741928714645,
+          0.13327407991024628,
+          0.13289516960994782,
+          0.13327398383523792,
+          0.1332741172301889,
+          0.1330850412231013,
+          0.1332742367928435,
+          0.13327400626875255,
+          0.13289517062354456,
+          0.13327419079755623
          ]
         },
         {
@@ -10283,16 +10136,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1973595113889399,
-          0.19735983812931557,
-          0.19735946791743775,
-          0.19735938959472082,
-          0.19735969684108765,
-          0.19735924298429788,
-          0.19735937345949545,
-          0.1990063359110804,
-          0.199006712363292,
-          0.19735940105937125
+          0.19735950442658862,
+          0.19735968275953797,
+          0.19900624706788203,
+          0.19735978268612245,
+          0.1973595844095166,
+          0.19870963661171065,
+          0.1973594514205202,
+          0.19735976030620445,
+          0.19900625115150042,
+          0.19735949229190836
          ]
         },
         {
@@ -10315,16 +10168,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.10853692118705047,
-          0.10853689021512258,
-          0.10853693206890347,
-          0.10853694996529267,
-          0.1085369099720527,
-          0.1085369349829387,
-          0.10853693378695406,
-          0.1082736312064217,
-          0.10827362310107974,
-          0.10853692030523897
+          0.10853692517629263,
+          0.10853693184089035,
+          0.10827363255860922,
+          0.10853690901222232,
+          0.10853690796402046,
+          0.10830322522744179,
+          0.108536931582595,
+          0.1085369149247257,
+          0.10827363566147878,
+          0.10853691681373434
          ]
         },
         {
@@ -10347,16 +10200,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.2588573465073455,
-          0.2588573465078335,
-          0.2588573465080282,
-          0.25885734650773,
-          0.2588573465069104,
-          0.25885734650733067,
-          0.2588573465077824,
-          0.25885804033559207,
-          0.25885804033639853,
-          0.2588573465073307
+          0.2588573465072768,
+          0.2588573465081933,
+          0.2588580403355945,
+          0.2588573465076048,
+          0.25885734650717296,
+          0.2588583457398106,
+          0.25885734650746944,
+          0.25885734650776815,
+          0.25885804033555426,
+          0.2588573465073141
          ]
         },
         {
@@ -10379,16 +10232,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12392868484191719,
-          0.12380944953018862,
-          0.12380953001552504,
-          0.12332980509709168,
-          0.12380952259385511,
-          0.12401259212099325,
-          0.12332981290276486,
-          0.12388639563248438,
-          0.12332981374420729,
-          0.12380951959667152
+          0.12380952460392487,
+          0.12380949939440875,
+          0.12368492198032882,
+          0.123798815369355,
+          0.12374544258136666,
+          0.12380956217223821,
+          0.12368732094624178,
+          0.12380945288048004,
+          0.1233298393660536,
+          0.12380942571804246
          ]
         },
         {
@@ -10411,16 +10264,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.042952448553920206,
-          0.043031625197254265,
-          0.043031604707106284,
-          0.04352116590333486,
-          0.043031604448303604,
-          0.04296013052365724,
-          0.043521165080091524,
-          0.04296131013262823,
-          0.04352116356045946,
-          0.04303160211137424
+          0.04303160318598734,
+          0.04303161244564823,
+          0.04307117903703139,
+          0.04301852896129934,
+          0.04300102508790793,
+          0.043031595693709124,
+          0.04302406209634267,
+          0.043031629353253956,
+          0.04352115812514805,
+          0.043031627524627566
          ]
         },
         {
@@ -10443,16 +10296,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0731393721032998,
-          0.07299521656682204,
-          0.0729952274262487,
-          0.07139561899894448,
-          0.07299522299949283,
-          0.07308821347926459,
-          0.07139562216462594,
-          0.07324016126666208,
-          0.07139562000527816,
-          0.07299521705844188
+          0.07299522180263004,
+          0.07299522346652557,
+          0.07300193188552112,
+          0.0730322736679486,
+          0.07323264088062205,
+          0.0729952303614482,
+          0.0732443815951998,
+          0.07299522566246011,
+          0.07139562559454973,
+          0.0729952070675931
          ]
         },
         {
@@ -10475,16 +10328,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.002915742592214039,
-          0.002915292959113036,
-          0.0029152929591607373,
-          0.002916019145891953,
-          0.0029152929591680266,
-          0.002915593113261146,
-          0.0029160191458091128,
-          0.0029154211695186253,
-          0.0029160191459061727,
-          0.002915292959155214
+          0.00291529295919913,
+          0.002915292959171244,
+          0.0029154953967398902,
+          0.002915387552058309,
+          0.0029155562690536914,
+          0.0029152929591654436,
+          0.0029158833334670927,
+          0.0029152929592355216,
+          0.002916019145827834,
+          0.0029152929592281226
          ]
         },
         {
@@ -10507,16 +10360,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08718954416304632,
-          0.08700032491060483,
-          0.08704782065422871,
-          0.08704782598173129,
-          0.0870478203304842,
-          0.08704781838343073,
-          0.08704781027233684,
-          0.08705163472677668,
-          0.08703054689441453,
-          0.08718954259588305
+          0.08704781480767745,
+          0.08707064718116675,
+          0.08710914778718462,
+          0.08710914984664477,
+          0.08718953310820693,
+          0.08704781848393471,
+          0.08704782259808275,
+          0.08708044007727278,
+          0.08704782296323291,
+          0.08707476209069914
          ]
         },
         {
@@ -10539,16 +10392,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.036045801208248664,
-          0.03618878125661401,
-          0.03617215705635431,
-          0.03617215602553299,
-          0.03617215749757106,
-          0.03617215819107167,
-          0.036172160598736264,
-          0.036175995248895934,
-          0.036176349631691744,
-          0.03604580177539012
+          0.036172158957551236,
+          0.0361679083896132,
+          0.03611834371757607,
+          0.03611834461158979,
+          0.0360458037342336,
+          0.03617215830882831,
+          0.036172156702081695,
+          0.03616882771122557,
+          0.036172156985049116,
+          0.036171119794298164
          ]
         },
         {
@@ -10571,16 +10424,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.19864981864931835,
-          0.19322034943154087,
-          0.19325840191532573,
-          0.19325840799903685,
-          0.1932584037682995,
-          0.1932584029574784,
-          0.19325839883214047,
-          0.19296113320478814,
-          0.19311097964304946,
-          0.1986498181726855
+          0.19325839955644736,
+          0.19324724143721694,
+          0.19534756250819968,
+          0.19534757176801515,
+          0.19864980802209192,
+          0.19325840391282856,
+          0.19325840427869823,
+          0.19300260194271296,
+          0.19325840640016412,
+          0.19312560777408144
          ]
         },
         {
@@ -10603,16 +10456,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0023157518228944015,
-          0.002315652478668309,
-          0.002315593340781246,
-          0.002315593340781093,
-          0.0023155933407806592,
-          0.002315593340781578,
-          0.00231559334078063,
-          0.0023156167748111345,
-          0.0023156207124329134,
-          0.002315751822891085
+          0.0023155933407807343,
+          0.0023156068855292844,
+          0.002315735235272556,
+          0.002315735235270817,
+          0.0023157518228929677,
+          0.0023155933407811146,
+          0.0023155933407815457,
+          0.0023156336003711817,
+          0.002315593340782002,
+          0.0023156471845013687
          ]
         }
        ],
@@ -11793,20 +11646,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"04934355-b437-4626-acbd-5b1eda91c6d9\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"9a15ab80-6e5f-4906-aaf9-060e9b4d0d55\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"04934355-b437-4626-acbd-5b1eda91c6d9\")) {\n",
+       "                if (document.getElementById(\"9a15ab80-6e5f-4906-aaf9-060e9b4d0d55\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        '04934355-b437-4626-acbd-5b1eda91c6d9',\n",
-       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.1407679898909402, 0.13937476631538367, 0.13977300095109937, 0.1395659679601429, 0.13925387235412634, 0.1397899944007349, 0.14048550401447726, 0.13917164507007296, 0.13932357844085694, 0.13934122196582824]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.27283606582229986, 0.27532844139206664, 0.2746038271933532, 0.27497034901341977, 0.2755281153889101, 0.2745172825185839, 0.27319145743215323, 0.27563824157266664, 0.275411081891578, 0.27527417548717376]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13106897509888263, 0.13100574650052207, 0.13100251279614267, 0.13099790348980117, 0.13097455745634579, 0.13098053386761524, 0.13102217174016928, 0.1309845176109183, 0.13096882466506812, 0.13096339160830717]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.03186628502705805, 0.031861225728881115, 0.03186079563743918, 0.03186055486488268, 0.0318604446508444, 0.03186176123880478, 0.031867534098104944, 0.031861103591720855, 0.031860188091619036, 0.031861143593183566]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07479928377326645, 0.07479931524986619, 0.07477543038886798, 0.07443693119031498, 0.07479928758490023, 0.07455485161561286, 0.0745542193197406, 0.07479929460002896, 0.07484129954693211, 0.07454904261356884]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1650351778227765, 0.16503508871520403, 0.16744134137100591, 0.16940011860301396, 0.16503516135165144, 0.1679110357361122, 0.1679124158778232, 0.1650351446869388, 0.16489787851452528, 0.1679842598223166]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.02038881391357691, 0.020388811065620183, 0.020314885322984578, 0.020274561393839017, 0.02038881287165887, 0.020313894523142566, 0.02031389981101447, 0.020388812624245935, 0.020394733735788102, 0.02031192008278776]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.007450327517825344, 0.00745032751782992, 0.007448891639474378, 0.007448563912800039, 0.007450327517830336, 0.0074482178222304435, 0.007448217820299516, 0.007450327517815607, 0.007450449935167196, 0.0074482325215940075]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2209043664932811, 0.2209043718094108, 0.22090437981791836, 0.2209043814829003, 0.22090439442144383, 0.22090437020411036, 0.22090438138452972, 0.22090438274169577, 0.2209043963004837, 0.2209043778913313]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05559246627706614, 0.05559246557183007, 0.05559246507974724, 0.05559246461297198, 0.05559246263832922, 0.05559246596714391, 0.05559246468762012, 0.05559246414303839, 0.05559246272479964, 0.0555924652407845]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [111.184932552725, 111.18493114365896, 111.18493015689738, 111.18492922594228, 111.18492527631244, 111.18493193428026, 111.18492937448522, 111.1849282858178, 111.1849254489108, 111.1849304815578]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.09948736196066063, 0.09948736196065341, 0.09948736196065976, 0.09948736196065494, 0.09948736196066824, 0.09948736196065383, 0.09948736196065515, 0.09948736196066087, 0.09948736196066683, 0.09948736196064864]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14902261389185176, 0.14902105155727188, 0.14958448559055923, 0.1489959034813328, 0.1491188852627464, 0.14904529812523212, 0.14807785118916483, 0.14825679584467907, 0.14900479171494763, 0.14899595862086748]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0542507566939512, 0.05426042133788948, 0.053774359577878954, 0.05426993853435017, 0.0542339804937269, 0.054251593767467604, 0.05479795553167865, 0.05477964348309504, 0.05425728397259722, 0.054265565173202725]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12875505172381224, 0.12877918951994433, 0.13097402363278957, 0.12877999106123053, 0.12884529749055185, 0.12882453549718775, 0.12668271600791964, 0.1267050691985729, 0.1288039197648813, 0.1287697527288394]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.040185458978753384, 0.04018452570624364, 0.040186565792226694, 0.04018469027460122, 0.040184927236240675, 0.04018472289075173, 0.040182812313316794, 0.040180870622448656, 0.0401847159948946, 0.0401846346930184]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08417659914510024, 0.08417665843808209, 0.08417668705121467, 0.08417662610500025, 0.0841766510640577, 0.08417664541336711, 0.08417663806490663, 0.08417665839409723, 0.08417664717902229, 0.08417666491328193]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05418269188301627, 0.054182679795135656, 0.05418267424677904, 0.054182687488731826, 0.054182681122606574, 0.05418268330017553, 0.05418268461596464, 0.05418268133848667, 0.05418268370337028, 0.054182678621191034]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [108.36538375515293, 108.36535958052431, 108.36534847915082, 108.36537495581446, 108.36536224383929, 108.36536658809221, 108.36536922451482, 108.36536267212061, 108.365367394371, 108.36535723202583]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1460431583367726, 0.14604315833667464, 0.14604315833684345, 0.14604315833671513, 0.14604315833665593, 0.14604315833669454, 0.14604315833667456, 0.1460431583366383, 0.14604315833665357, 0.14604315833656836]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13327418322427875, 0.13327392291528162, 0.13327422612284356, 0.1332743015139473, 0.13327404332908582, 0.13327438261588548, 0.13327429244301378, 0.13289510885504063, 0.1328948488468126, 0.133274257028495]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1973595113889399, 0.19735983812931557, 0.19735946791743775, 0.19735938959472082, 0.19735969684108765, 0.19735924298429788, 0.19735937345949545, 0.1990063359110804, 0.199006712363292, 0.19735940105937125]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10853692118705047, 0.10853689021512258, 0.10853693206890347, 0.10853694996529267, 0.1085369099720527, 0.1085369349829387, 0.10853693378695406, 0.1082736312064217, 0.10827362310107974, 0.10853692030523897]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2588573465073455, 0.2588573465078335, 0.2588573465080282, 0.25885734650773, 0.2588573465069104, 0.25885734650733067, 0.2588573465077824, 0.25885804033559207, 0.25885804033639853, 0.2588573465073307]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12392868484191719, 0.12380944953018862, 0.12380953001552504, 0.12332980509709168, 0.12380952259385511, 0.12401259212099325, 0.12332981290276486, 0.12388639563248438, 0.12332981374420729, 0.12380951959667152]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.042952448553920206, 0.043031625197254265, 0.043031604707106284, 0.04352116590333486, 0.043031604448303604, 0.04296013052365724, 0.043521165080091524, 0.04296131013262823, 0.04352116356045946, 0.04303160211137424]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0731393721032998, 0.07299521656682204, 0.0729952274262487, 0.07139561899894448, 0.07299522299949283, 0.07308821347926459, 0.07139562216462594, 0.07324016126666208, 0.07139562000527816, 0.07299521705844188]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.002915742592214039, 0.002915292959113036, 0.0029152929591607373, 0.002916019145891953, 0.0029152929591680266, 0.002915593113261146, 0.0029160191458091128, 0.0029154211695186253, 0.0029160191459061727, 0.002915292959155214]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08718954416304632, 0.08700032491060483, 0.08704782065422871, 0.08704782598173129, 0.0870478203304842, 0.08704781838343073, 0.08704781027233684, 0.08705163472677668, 0.08703054689441453, 0.08718954259588305]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.036045801208248664, 0.03618878125661401, 0.03617215705635431, 0.03617215602553299, 0.03617215749757106, 0.03617215819107167, 0.036172160598736264, 0.036175995248895934, 0.036176349631691744, 0.03604580177539012]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19864981864931835, 0.19322034943154087, 0.19325840191532573, 0.19325840799903685, 0.1932584037682995, 0.1932584029574784, 0.19325839883214047, 0.19296113320478814, 0.19311097964304946, 0.1986498181726855]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0023157518228944015, 0.002315652478668309, 0.002315593340781246, 0.002315593340781093, 0.0023155933407806592, 0.002315593340781578, 0.00231559334078063, 0.0023156167748111345, 0.0023156207124329134, 0.002315751822891085]}],\n",
+       "                        '9a15ab80-6e5f-4906-aaf9-060e9b4d0d55',\n",
+       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13918719165099708, 0.14055115195712864, 0.13932395387017527, 0.13943859454630717, 0.13979298016345132, 0.13902481164586789, 0.1386972899219595, 0.13903615339402747, 0.13916046682005412, 0.1394914121331874]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.27564483940463885, 0.2731491955393398, 0.2754104065201399, 0.27511443456742835, 0.2744336140315837, 0.2759827064804965, 0.2764772283947938, 0.2758600699375978, 0.27590785909120547, 0.2750283532537084]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.1309855719413908, 0.13102688288099468, 0.13096885082260643, 0.13095848417226005, 0.13095003928756968, 0.13097293759549078, 0.13090766243972243, 0.13092460822035862, 0.13088154888469347, 0.13098251490347287]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.031861044387893, 0.03186657886674443, 0.03186018809268653, 0.03186132366057374, 0.03186510872583087, 0.03186130971115906, 0.03186164765003843, 0.03186112279970249, 0.03188295194173178, 0.031860910862734224]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07443659963620419, 0.07462314826271575, 0.07479932076333078, 0.07479927771253134, 0.07454892839008512, 0.0747992621013509, 0.07479928905831912, 0.07455488705752467, 0.07454902241485084, 0.0747993112332315]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1694008172125861, 0.167900555995953, 0.16503508120383462, 0.1650351812152207, 0.1679844731200665, 0.16503521542192892, 0.16503515762648371, 0.16791092099838076, 0.16798428265869367, 0.16503509248217985]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.020274559389377386, 0.02032151694361342, 0.020388811566643746, 0.02038881276825506, 0.020311916648156937, 0.020388812947371972, 0.020388812794037803, 0.020313889720233232, 0.020311917622961143, 0.020388810492726818]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.007448563913034786, 0.007448853502447956, 0.007450327517833169, 0.007450327517830882, 0.0074482325209846425, 0.007450327517829625, 0.007450327517832178, 0.007448217820324642, 0.00744823252150573, 0.0074503275178434015]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2209043946194997, 0.22090438355020525, 0.22090437429756848, 0.22090437788921907, 0.22090437786125117, 0.22090436669496116, 0.22090437224142262, 0.2209043669029539, 0.22090437393227635, 0.22090438692679815]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05559246315919802, 0.05559246422770951, 0.05559246592456908, 0.0555924649990488, 0.05559246491120858, 0.05559246670615155, 0.05559246599016961, 0.05559246618047994, 0.0555924655732377, 0.055592463237242956]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [111.18492631822055, 111.18492845513195, 111.18493184886286, 111.18492999775414, 111.18492982232804, 111.18493341230001, 111.18493198032684, 111.18493236091, 111.18493114639548, 111.18492647443941]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.09948736196066517, 0.09948736196066746, 0.09948736196065906, 0.09948736196065563, 0.09948736196065783, 0.0994873619606613, 0.09948736196065448, 0.09948736196065806, 0.09948736196065261, 0.09948736196066187]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14772732140769995, 0.1492531105350668, 0.14975726679131654, 0.149024825824303, 0.14902087422209886, 0.14905204032236427, 0.1498226790272666, 0.1488772212919028, 0.1488923322261044, 0.14903078755899457]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05492887917841991, 0.05419604794079209, 0.05372151810207286, 0.05425644982046511, 0.05426047446100451, 0.05424562968010625, 0.0537164170062778, 0.054622660248930484, 0.05428778016880158, 0.05425130560602975]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12664863955029032, 0.12886916492355552, 0.13107072788242094, 0.12882792046502914, 0.12877916590622596, 0.1288179897255562, 0.13114332429186307, 0.12685128776653432, 0.12878230004914287, 0.12881240859434887]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04018404846380736, 0.04018534348023183, 0.04018682191754251, 0.04018628711400928, 0.04018452570693834, 0.04018505155829083, 0.0401876434620321, 0.040184109591550186, 0.040185066029155975, 0.04018484056712653]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0841765936775836, 0.08417664540218445, 0.08417667879396355, 0.0841766445542802, 0.0841766510774928, 0.08417664170428385, 0.08417663881025533, 0.08417663255156192, 0.08417664424039117, 0.084176654761254]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05418269486184153, 0.05418268266543908, 0.0541826760578243, 0.054182683231441355, 0.054182681131329874, 0.05418268299251343, 0.05418268333011582, 0.05418268474778009, 0.05418268334411255, 0.054182681001905854]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [108.36538971275093, 108.36536533045755, 108.36535210790096, 108.36536641689752, 108.36536216013873, 108.36536597166514, 108.36536665332109, 108.3653694579857, 108.36536668565707, 108.36536200240135]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14604315833668158, 0.14604315833665787, 0.1460431583368346, 0.14604315833671455, 0.1460431583368069, 0.14604315833669482, 0.14604315833677542, 0.14604315833675832, 0.1460431583366878, 0.14604315833655096]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1332741928714645, 0.13327407991024628, 0.13289516960994782, 0.13327398383523792, 0.1332741172301889, 0.1330850412231013, 0.1332742367928435, 0.13327400626875255, 0.13289517062354456, 0.13327419079755623]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19735950442658862, 0.19735968275953797, 0.19900624706788203, 0.19735978268612245, 0.1973595844095166, 0.19870963661171065, 0.1973594514205202, 0.19735976030620445, 0.19900625115150042, 0.19735949229190836]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10853692517629263, 0.10853693184089035, 0.10827363255860922, 0.10853690901222232, 0.10853690796402046, 0.10830322522744179, 0.108536931582595, 0.1085369149247257, 0.10827363566147878, 0.10853691681373434]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2588573465072768, 0.2588573465081933, 0.2588580403355945, 0.2588573465076048, 0.25885734650717296, 0.2588583457398106, 0.25885734650746944, 0.25885734650776815, 0.25885804033555426, 0.2588573465073141]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12380952460392487, 0.12380949939440875, 0.12368492198032882, 0.123798815369355, 0.12374544258136666, 0.12380956217223821, 0.12368732094624178, 0.12380945288048004, 0.1233298393660536, 0.12380942571804246]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04303160318598734, 0.04303161244564823, 0.04307117903703139, 0.04301852896129934, 0.04300102508790793, 0.043031595693709124, 0.04302406209634267, 0.043031629353253956, 0.04352115812514805, 0.043031627524627566]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07299522180263004, 0.07299522346652557, 0.07300193188552112, 0.0730322736679486, 0.07323264088062205, 0.0729952303614482, 0.0732443815951998, 0.07299522566246011, 0.07139562559454973, 0.0729952070675931]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.00291529295919913, 0.002915292959171244, 0.0029154953967398902, 0.002915387552058309, 0.0029155562690536914, 0.0029152929591654436, 0.0029158833334670927, 0.0029152929592355216, 0.002916019145827834, 0.0029152929592281226]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704781480767745, 0.08707064718116675, 0.08710914778718462, 0.08710914984664477, 0.08718953310820693, 0.08704781848393471, 0.08704782259808275, 0.08708044007727278, 0.08704782296323291, 0.08707476209069914]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.036172158957551236, 0.0361679083896132, 0.03611834371757607, 0.03611834461158979, 0.0360458037342336, 0.03617215830882831, 0.036172156702081695, 0.03616882771122557, 0.036172156985049116, 0.036171119794298164]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19325839955644736, 0.19324724143721694, 0.19534756250819968, 0.19534757176801515, 0.19864980802209192, 0.19325840391282856, 0.19325840427869823, 0.19300260194271296, 0.19325840640016412, 0.19312560777408144]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0023155933407807343, 0.0023156068855292844, 0.002315735235272556, 0.002315735235270817, 0.0023157518228929677, 0.0023155933407811146, 0.0023155933407815457, 0.0023156336003711817, 0.002315593340782002, 0.0023156471845013687]}],\n",
        "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"visible\": [true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 40\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 94\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 95\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 136\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 140\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 155\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false]}], \"label\": \"ID: 169\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true]}], \"label\": \"ID: 170\", \"method\": \"restyle\"}], \"direction\": \"right\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"yaxis\": {\"title\": {\"text\": \"Estimates\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('04934355-b437-4626-acbd-5b1eda91c6d9');\n",
+       "var gd = document.getElementById('9a15ab80-6e5f-4906-aaf9-060e9b4d0d55');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -11895,7 +11748,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 10,
+   "execution_count": 14,
    "metadata": {
     "tags": []
    },
@@ -11903,7 +11756,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "b165bf594bac486b937b2785cd267374",
+       "model_id": "af19c21d3d694bac9033605d3e55ade1",
        "version_major": 2,
        "version_minor": 0
       },
@@ -11929,7 +11782,6 @@
     "\n",
     "import os\n",
     "\n",
-    "import myokit\n",
     "import numpy as np\n",
     "import pandas as pd\n",
     "import pints\n",
@@ -11942,84 +11794,46 @@
     "n_runs = 10\n",
     "\n",
     "# Import data\n",
-    "# Get path of current working directory\n",
     "path = os.getcwd()\n",
-    "\n",
-    "# Import LXF A677 control growth data\n",
     "data = pd.read_csv(path + '/data/lxf_control_growth.csv')\n",
     "\n",
     "# Define model\n",
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - Eigenmann et. al.')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=True)\n",
     "\n",
-    "# Define container for the structural model estimates\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
+    "# Define initial parameters\n",
     "n_mice = len(data['#ID'].unique())\n",
-    "n_parameters = 3\n",
-    "parameters_log = np.empty(shape=(n_mice, n_runs, n_parameters))\n",
-    "\n",
-    "# Define container for the objective function score for the optimised parameters\n",
-    "scores_log = np.empty(shape=(n_mice, n_runs))\n",
-    "\n",
-    "# Define random starting points over many orders of magnitude\n",
-    "# Shape = (n_runs, n_parameters)\n",
+    "n_parameters = model.n_parameters()\n",
     "initial_parameters = np.random.uniform(low=1E-3, high=1E3, size=(n_runs, n_parameters))\n",
+    "log_init_params = np.log(initial_parameters)\n",
+    "\n",
+    "# Create boundaries to biologically relevant values\n",
+    "boundaries = pints.RectangularBoundaries(\n",
+    "    lower=np.log([1E-3] * n_parameters), upper=np.log([1E3] * n_parameters))\n",
     "\n",
-    "# Find mouse parameters for LXF A677 population\n",
+    "# Find parameters for each mouse\n",
+    "parameters_log = []\n",
+    "scores_log = []\n",
     "mouse_ids = data['#ID'].unique()\n",
     "for index, mouse_id in enumerate(tqdm(mouse_ids)):\n",
-    "    # Create mask for mouse with specfied ID\n",
+    "    # Get data\n",
     "    mouse_mask = data['#ID'] == mouse_id\n",
-    "\n",
-    "    # Get relevant time points\n",
     "    times = data[mouse_mask]['TIME in day'].to_numpy()\n",
-    "\n",
-    "    # Get measured tumour volumes\n",
     "    observed_volumes = data[mouse_mask]['TUMOUR VOLUME in cm^3'].to_numpy()\n",
     "\n",
     "    # Create inverse problem\n",
     "    problem = pints.SingleOutputProblem(model, times, observed_volumes)\n",
-    "\n",
-    "    # Create sum of squares error objective function\n",
     "    error = pints.SumOfSquaresError(problem)\n",
     "\n",
-    "    # Create boundaries to biologically relevant values\n",
-    "    boundary = pints.RectangularBoundaries(lower=np.log([1E-3]*3), upper=np.log([1E3]*3))\n",
-    "\n",
-    "    # Run optimisation multiple times\n",
-    "    for run_id, initial_params in enumerate(initial_parameters):\n",
-    "        # Transform parameters to log-scale\n",
-    "        log_initial_params = np.log(initial_params)\n",
-    "\n",
-    "        # Create optimisation controller with a CMA-ES optimiser\n",
-    "        optimiser = pints.OptimisationController(\n",
-    "            function=error,\n",
-    "            x0=log_initial_params,\n",
-    "            boundaries=boundary,\n",
-    "            method=pints.CMAES)\n",
-    "\n",
-    "        # Disable logging mode\n",
-    "        optimiser.set_log_to_screen(False)\n",
-    "\n",
-    "        # Parallelise optimisation\n",
-    "        optimiser.set_parallel(True)\n",
-    "\n",
-    "        # Find optimal parameters\n",
-    "        try:\n",
-    "            estimates, score = optimiser.run()\n",
-    "        except:\n",
-    "            # If inference breaks fill estimates with nan\n",
-    "            estimates = np.array([np.nan, np.nan, np.nan])\n",
-    "            score = np.nan\n",
-    "\n",
-    "        # Save estimates and score (back transformed to linear scale)\n",
-    "        parameters_log[index, run_id, :] = np.exp(estimates)\n",
-    "        scores_log[index, run_id] = score"
+    "    # Run optimisation multiple times and safe back transformed parameters\n",
+    "    p, s = pkpd.optimise(error, pints.CMAES, log_init_params, n_runs, boundaries)\n",
+    "    parameters_log += [np.exp(p)]\n",
+    "    scores_log += [s]"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 11,
+   "execution_count": 15,
    "metadata": {},
    "outputs": [
     {
@@ -12049,16 +11863,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13983398773789008,
-          0.13771748269480014,
-          0.1386593020747166,
-          0.13975397479474247,
-          0.13928983843427617,
-          0.13958851779248066,
-          0.13932278496763678,
-          0.14132917519021643,
-          0.1391167674102394,
-          0.13916046887296143
+          0.1392851204115826,
+          0.14004039570205634,
+          0.13905237643227727,
+          0.13868812753481052,
+          0.1396645367594054,
+          0.13915728864434526,
+          0.13958613710568685,
+          0.13903799443532208,
+          0.13948556890951266,
+          0.13954619280890204
          ]
         },
         {
@@ -12081,16 +11895,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.27453700570873707,
-          0.2849538418273704,
-          0.2765260196692814,
-          0.27458090586042516,
-          0.2754230018741792,
-          0.27507561898092947,
-          0.27541250786640414,
-          0.2655248641553643,
-          0.2757617694420596,
-          0.2759078217644991
+          0.2754200383483037,
+          0.2740601236941595,
+          0.2757583816214603,
+          0.27653425953704647,
+          0.2747174785079591,
+          0.275630398378277,
+          0.2749266586622544,
+          0.2759065022262726,
+          0.27506754320574284,
+          0.27499060028051414
          ]
         },
         {
@@ -12113,16 +11927,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.1310283362599498,
-          0.12961965410548917,
-          0.13089563133928536,
-          0.13101799303024275,
-          0.13094350571474941,
-          0.13105413025811996,
-          0.1309687678289964,
-          0.13244670111303702,
-          0.13095744989502825,
-          0.13088156975419624
+          0.13097592114938542,
+          0.13099590556403654,
+          0.13093181345952015,
+          0.13093969357496305,
+          0.13095644386949143,
+          0.1309570930550862,
+          0.13098116769946067,
+          0.1309549647144671,
+          0.13097003096452636,
+          0.13098850993927486
          ]
         },
         {
@@ -12145,16 +11959,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.031861260561797757,
-          0.031902731658678546,
-          0.03186214563151602,
-          0.031861242450875016,
-          0.03186076747409567,
-          0.03186491459684502,
-          0.03186018808997758,
-          0.031908105161659026,
-          0.031860480914349516,
-          0.03188295194334326
+          0.03186067573123524,
+          0.03186301633492758,
+          0.031861954163742295,
+          0.031861927960031254,
+          0.031862431367059976,
+          0.03186083903524911,
+          0.031860475916730635,
+          0.031860639622121344,
+          0.03186073888169228,
+          0.03186049979162137
          ]
         },
         {
@@ -12177,16 +11991,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07436037505356735,
-          0.07443702203446759,
-          0.07530407040221626,
-          0.07504825029952791,
-          0.07443672699650672,
-          0.05754159303617008,
-          0.07443722339267538,
-          0.07446509808101025,
-          0.07443707122812038,
-          0.0747992940109134
+          0.07455438994349883,
+          0.07455410906185411,
+          0.07451512953234525,
+          0.07454238463860978,
+          0.05752213434109045,
+          0.07479930631895164,
+          0.07455509514591267,
+          0.07455475544889653,
+          0.07443708832512272,
+          0.0747993087799642
          ]
         },
         {
@@ -12209,16 +12023,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.16928251243146844,
-          0.16940019611560622,
-          0.1589678016967297,
-          0.16693604394210732,
-          0.16940072690624422,
-          173.3310835081715,
-          0.1693994792200431,
-          0.16817048614806004,
-          0.16939983039465822,
-          0.16503514646726813
+          0.16791181480795098,
+          0.16791236247627161,
+          0.16801192996771316,
+          0.16791272067891927,
+          999.9999976503309,
+          0.165035099159095,
+          0.16791038108629744,
+          0.16791128184476964,
+          0.16939988244893592,
+          0.16503510904029453
          ]
         },
         {
@@ -12241,16 +12055,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.020264075503835945,
-          0.020274594131979993,
-          0.020569155439883677,
-          0.02031256847321828,
-          0.02027458148097293,
-          0.016441180660032084,
-          0.02027456031025442,
-          0.020322505901725584,
-          0.02027456306191351,
-          0.02038881269970394
+          0.02031387074794752,
+          0.02031386516121883,
+          0.02031611597895983,
+          0.020312234490651157,
+          0.016438528639122305,
+          0.020388810031782435,
+          0.02031387758526599,
+          0.020313899734684712,
+          0.020274573686690212,
+          0.02038881190100759
          ]
         },
         {
@@ -12273,16 +12087,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.00745041864858885,
-          0.0074485639177765345,
-          0.007451668871959789,
-          0.007450052037112911,
-          0.007448563914315658,
-          0.008273018389497507,
-          0.007448563913431537,
-          0.007448437678056302,
-          0.007448563913247223,
-          0.0074503275178349915
+          0.007448217821041958,
+          0.0074482178246310805,
+          0.007448272542574417,
+          0.007448526934921553,
+          0.008274993986078791,
+          0.00745032751780821,
+          0.007448217820574983,
+          0.007448217820500015,
+          0.007448563914002162,
+          0.007450327517829286
          ]
         },
         {
@@ -12305,16 +12119,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0011630689422144902,
-          0.22106914510298661,
-          0.2210691338840678,
-          0.22106913770105283,
-          0.2210691377996519,
-          0.0020829275155398114,
-          0.221069137675521,
-          0.22106912465266745,
-          0.22106914511346223,
-          0.22106913377857623
+          0.221069126632069,
+          0.2210691372133391,
+          0.2210691339760097,
+          0.22106913375685563,
+          0.004974283603890213,
+          0.2210691376322354,
+          0.22106914515163315,
+          0.2210691395905615,
+          0.22106913741914241,
+          0.22106913223034524
          ]
         },
         {
@@ -12337,16 +12151,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          93.5706298672042,
-          0.05553423927208928,
-          0.05553424048702996,
-          0.055534239433662265,
-          0.05553423998035164,
-          460.711511118009,
-          0.05553423996386114,
-          0.05553424115730465,
-          0.05553423926938946,
-          0.05553424043790153
+          0.05553424116377097,
+          0.055534239543550024,
+          0.05553424046952728,
+          0.055534240444379226,
+          608.0694830701036,
+          0.055534240070064675,
+          0.055534239074257176,
+          0.05553424015931904,
+          0.05553423996141367,
+          0.055534240335311104
          ]
         },
         {
@@ -12369,16 +12183,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08859734250578861,
-          999.9999999870572,
-          999.9999999514253,
-          999.9999999998896,
-          999.999999994851,
-          0.08832178150220801,
-          999.9999999793195,
-          999.9999999998763,
-          999.9999999973965,
-          999.9999999999101
+          999.9999999998328,
+          999.999999995478,
+          999.9999999626199,
+          999.9999999759995,
+          0.08806177670775409,
+          999.9999999729192,
+          999.9999999947364,
+          999.9999999648057,
+          999.999999999116,
+          999.9999999973032
          ]
         },
         {
@@ -12401,16 +12215,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.5367134747993929,
-          0.0993183674990417,
-          0.09931836749904159,
-          0.09931836749904441,
-          0.09931836749904116,
-          0.5372396765884546,
-          0.09931836749904305,
-          0.09931836749904528,
-          0.09931836749904131,
-          0.09931836749904181
+          0.09931836749904324,
+          0.09931836749904487,
+          0.09931836749904109,
+          0.09931836749904271,
+          0.5377443689269127,
+          0.09931836749904117,
+          0.09931836749904512,
+          0.09931836749904417,
+          0.0993183674990437,
+          0.09931836749904165
          ]
         },
         {
@@ -12433,16 +12247,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14828976391920154,
-          0.1483356604492424,
-          0.14798503323998585,
-          0.1490937371722133,
-          0.14840182872892718,
-          0.14822181586741134,
-          0.14885038057762817,
-          0.14903263611839554,
-          0.14817421964439634,
-          0.14903216720033782
+          0.15016669956620154,
+          0.14905104486597168,
+          0.1483274113739557,
+          0.14980578731924576,
+          0.14898566577627836,
+          0.1482010581538367,
+          0.14835141969502097,
+          0.14903790294836744,
+          0.14908065183212812,
+          0.14804268977525115
          ]
         },
         {
@@ -12465,16 +12279,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.054762579874712024,
-          0.05474473067407753,
-          0.05482370624069295,
-          0.05424049347491106,
-          0.054742051187412336,
-          0.05478098123964825,
-          0.054630517460012615,
-          0.054252046708967785,
-          0.05477614904019722,
-          0.054252161920021705
+          0.05362103582069221,
+          0.054255536540699714,
+          0.054763868580570856,
+          0.05372455017806364,
+          0.054264312548434605,
+          0.054783443645536736,
+          0.05472974143463991,
+          0.05425352652068387,
+          0.054246780267489816,
+          0.05483905945557663
          ]
         },
         {
@@ -12497,16 +12311,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12663388547445986,
-          0.12665617954067654,
-          0.1266264678461157,
-          0.12883899151545877,
-          0.12671587959881883,
-          0.126726186519302,
-          0.1269354810557872,
-          0.12881405774298002,
-          0.12678140677007177,
-          0.12881393535772673
+          0.13118299967284933,
+          0.1287927483370258,
+          0.1266948471137335,
+          0.13106912477572588,
+          0.12880415721419705,
+          0.12664205362831465,
+          0.12666164297435048,
+          0.12882230228613717,
+          0.12884234334529895,
+          0.12658937815095056
          ]
         },
         {
@@ -12529,16 +12343,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.040182854752698685,
-          0.04018327808749114,
-          0.04018412277454137,
-          0.04018478585849564,
-          0.040181272068298454,
-          0.040180694547922356,
-          0.040183872421800215,
-          0.0401845034478281,
-          0.04018043716521562,
-          0.040184503449504826
+          0.040188184658851864,
+          0.04018460673832794,
+          0.040181140782483686,
+          0.04018665916254997,
+          0.04018465512181828,
+          0.040182362903006225,
+          0.0401849672700523,
+          0.040184603230236184,
+          0.04018482577283232,
+          0.04018199003233114
          ]
         },
         {
@@ -12561,16 +12375,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08430030781422934,
-          0.08430037774995375,
-          0.08430036866936687,
-          0.08430035897698927,
-          0.08430035621461948,
-          0.08430034274896674,
-          0.08430035491782215,
-          0.0843003327794982,
-          0.08430037338189834,
-          0.08430034016373823
+          0.08430038081392585,
+          0.08430037970506372,
+          0.08430037155117036,
+          0.08430035126921527,
+          0.08430035841480026,
+          0.08430035491697263,
+          0.08430034100703146,
+          0.08430033274843024,
+          0.0843003557843038,
+          0.084300370588152
          ]
         },
         {
@@ -12593,16 +12407,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05412915758671947,
-          0.054129143632696164,
-          0.05412914448153982,
-          0.05412914768332539,
-          0.054129148951724784,
-          0.0541291506861551,
-          0.05412914726353322,
-          0.054129152327057936,
-          0.05412914426183218,
-          0.05412915190846893
+          0.05412914294047922,
+          0.05412914239653237,
+          0.05412914522065667,
+          0.054129148901242465,
+          0.05412914698005298,
+          0.05412914841863741,
+          0.054129151242718124,
+          0.0541291537250366,
+          0.05412914881234599,
+          0.05412914551012188
          ]
         },
         {
@@ -12625,16 +12439,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          999.9999998721331,
-          999.9999988626233,
-          999.9999999268645,
-          999.9999999581008,
-          999.999998392451,
-          999.9999996993558,
-          999.9999998608826,
-          999.9999999998728,
-          999.9999999189961,
-          999.9999977271059
+          999.9999999939886,
+          999.9999999871807,
+          999.9999999998914,
+          999.9999998032798,
+          999.9999992892572,
+          999.9999997371256,
+          999.9999999964808,
+          999.9999999322247,
+          999.9999998184694,
+          999.9999992835808
          ]
         },
         {
@@ -12657,16 +12471,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1458908359091616,
-          0.14589083590905721,
-          0.14589083590912394,
-          0.1458908359092176,
-          0.14589083590919066,
-          0.14589083590916613,
-          0.14589083590906995,
-          0.1458908359091734,
-          0.14589083590907928,
-          0.1458908359090948
+          0.14589083590908689,
+          0.14589083590903856,
+          0.14589083590918286,
+          0.14589083590904295,
+          0.14589083590909893,
+          0.1458908359091335,
+          0.14589083590910354,
+          0.14589083590916227,
+          0.14589083590902818,
+          0.14589083590903532
          ]
         },
         {
@@ -12689,16 +12503,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1332739413860922,
-          0.13327450840552188,
-          0.13327409098283813,
-          0.13327427227064745,
-          0.0020473863551791595,
-          0.1328949636062283,
-          0.13327392204317762,
-          0.13289504555800769,
-          0.1332740171004246,
-          0.1328952418387591
+          0.13327410368892498,
+          0.1332743410978899,
+          0.13327394889458682,
+          0.13327425535210488,
+          0.13289519010564083,
+          0.13327391779004494,
+          0.13289558459533607,
+          0.13327431455570943,
+          0.13327417652574294,
+          0.13289503501668934
          ]
         },
         {
@@ -12721,16 +12535,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.19735982400107102,
-          0.19735911755400204,
-          0.19735963114146649,
-          0.19735940576415517,
-          4.537257653656653,
-          0.19900653079368896,
-          0.19735983732596896,
-          0.1990064155584879,
-          0.19735972341785318,
-          0.1990061444910501
+          0.19735962353339268,
+          0.19735930493332196,
+          0.1973598213385605,
+          0.19735943147757953,
+          0.1990062099835243,
+          0.19735988699733523,
+          0.19900570810878687,
+          0.19735935824750397,
+          0.1973595056197694,
+          0.19900642321390105
          ]
         },
         {
@@ -12753,16 +12567,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.10853689744092339,
-          0.10853696801049226,
-          0.10853691245307842,
-          0.10853693528059902,
-          0.08396566444590167,
-          0.10827361831177093,
-          0.10853688922153729,
-          0.10827362271419873,
-          0.10853690335130634,
-          0.10827363584434666
+          0.10853691851282173,
+          0.10853693542367951,
+          0.10853690211613584,
+          0.10853693577321798,
+          0.10827362922100846,
+          0.10853691296117403,
+          0.10827367916402188,
+          0.10853694323129867,
+          0.10853691265044688,
+          0.10827361825796838
          ]
         },
         {
@@ -12785,16 +12599,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.25885734650720643,
-          0.2588573465086307,
-          0.25885734650737563,
-          0.2588573465076609,
-          0.28740532209973224,
-          0.25885804033561943,
-          0.2588573465079799,
-          0.2588580403355452,
-          0.2588573465066859,
-          0.2588580403356153
+          0.25885734650706005,
+          0.25885734650732106,
+          0.25885734650780357,
+          0.25885734650820247,
+          0.2588580403357222,
+          0.25885734650807396,
+          0.2588580403381629,
+          0.2588573465068696,
+          0.25885734650768394,
+          0.25885804033559684
          ]
         },
         {
@@ -12817,16 +12631,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12380948767823123,
-          0.1238094145598743,
-          0.1238095182291284,
-          0.1233297959626745,
-          0.12380950421327185,
-          0.12391655763859713,
-          0.15810350153858807,
-          0.123743146702017,
-          0.12332979642154858,
-          0.12332975427190758
+          0.12332979026816429,
+          0.12332977941174503,
+          0.12332979053339828,
+          0.12380950713647192,
+          0.12332978667483444,
+          0.12332981860536438,
+          0.12380952694377675,
+          0.12380951806079654,
+          0.12332978126856639,
+          0.12380950133916431
          ]
         },
         {
@@ -12849,16 +12663,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.04303161973936419,
-          0.043031636681335396,
-          0.043031608373383,
-          0.043521169194966035,
-          0.04303160837803432,
-          0.04299986270025447,
-          0.027433063802177884,
-          0.04302279571119958,
-          0.04352116717558906,
-          0.043521181361618144
+          0.0435211708650278,
+          0.04352117234259924,
+          0.04352117278851517,
+          0.043031610973438814,
+          0.04352116806988983,
+          0.04352116238438866,
+          0.04303160418372592,
+          0.04303160762020921,
+          0.043521172242730624,
+          0.04303161034751216
          ]
         },
         {
@@ -12881,16 +12695,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07299522900201687,
-          0.07299521658383627,
-          0.07299522733112966,
-          0.07139561931785986,
-          0.07299521922627324,
-          0.07306644152702906,
-          306.6945687740285,
-          0.0730755500451832,
-          0.07139561623848342,
-          0.0713956158593473
+          0.07139561891391966,
+          0.0713956151982025,
+          0.07139562219901491,
+          0.07299522510163682,
+          0.07139561224903561,
+          0.07139562085269828,
+          0.07299522511002009,
+          0.07299522587262644,
+          0.07139561606175703,
+          0.07299522094757457
          ]
         },
         {
@@ -12913,16 +12727,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0029152929592282644,
-          0.002915292959232122,
-          0.00291529295922348,
-          0.0029160191458655403,
-          0.002915292959146958,
-          0.0029155267267136054,
-          0.013341535720631835,
-          0.002915496492517192,
-          0.0029160191458860642,
-          0.00291601914588176
+          0.002916019145793012,
+          0.0029160191458414446,
+          0.0029160191458351943,
+          0.0029152929592019387,
+          0.0029160191458863886,
+          0.002916019145865676,
+          0.00291529295919757,
+          0.002915292959220924,
+          0.0029160191458435128,
+          0.002915292959267321
          ]
         },
         {
@@ -12945,16 +12759,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08707009011535931,
-          0.08704781832200564,
-          0.08707623907343993,
-          0.08718953849924779,
-          0.08704781331697091,
-          0.08701454179409313,
-          0.08704779680512383,
-          0.08704782657848452,
-          0.08704780571290119,
-          0.08704782483555105
+          0.08704783475245334,
+          0.08704781996003096,
+          0.08703075329333192,
+          0.08700295149788846,
+          0.08703258503191778,
+          0.08704782418064302,
+          0.0870478181254243,
+          0.08707721921117172,
+          0.08704782024538392,
+          0.08704782843919136
          ]
         },
         {
@@ -12977,16 +12791,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.036172420392150864,
-          0.03617215791973824,
-          0.03616172356843205,
-          0.03604580287799593,
-          0.03617215887543982,
-          0.03618780586832674,
-          0.036172164517218115,
-          0.03617215616471199,
-          0.0361721609229211,
-          0.03617215630556514
+          0.03617215355158731,
+          0.036172157733910346,
+          0.03617158169264879,
+          0.03617981997071207,
+          0.036180030214612836,
+          0.03617215649669775,
+          0.03617215798956962,
+          0.03616591680727679,
+          0.03617215762561426,
+          0.03617215490947538
          ]
         },
         {
@@ -13009,16 +12823,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.19313866427104703,
-          0.19325840164680377,
-          0.1932477268580154,
-          0.19864981541945412,
-          0.19325839566333133,
-          0.19291031031375563,
-          0.19325839048625018,
-          0.19325840981898587,
-          0.19325839036964382,
-          0.1932584068900676
+          0.19325841381028366,
+          0.1932584040550206,
+          0.19321657253276622,
+          0.19306142095660297,
+          0.1930417442287894,
+          0.19325840667993138,
+          0.1932584013559515,
+          0.1931868542065503,
+          0.19325840433497601,
+          0.19325840728386953
          ]
         },
         {
@@ -13041,16 +12855,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0023156482274348193,
-          0.0023155933407807273,
-          0.00231562848310746,
-          0.0023157518228968305,
-          0.0023155933407827574,
-          0.0023156285132839823,
-          0.0023155933407873405,
-          0.00231559334078217,
-          0.002315593340783853,
-          0.0023155933407812703
+          0.0023155933407827795,
+          0.0023155933407809515,
+          0.0023156671210871316,
+          0.002315734076343765,
+          0.0023156103642519186,
+          0.002315593340780316,
+          0.002315593340781343,
+          0.0023156120564454706,
+          0.0023155933407800425,
+          0.0023155933407823224
          ]
         }
        ],
@@ -14231,20 +14045,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"b5d4473e-c05d-4fa7-bc48-611a7998b2fe\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"72c5acc1-948e-45b6-879f-cff7b855b242\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"b5d4473e-c05d-4fa7-bc48-611a7998b2fe\")) {\n",
+       "                if (document.getElementById(\"72c5acc1-948e-45b6-879f-cff7b855b242\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        'b5d4473e-c05d-4fa7-bc48-611a7998b2fe',\n",
-       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13983398773789008, 0.13771748269480014, 0.1386593020747166, 0.13975397479474247, 0.13928983843427617, 0.13958851779248066, 0.13932278496763678, 0.14132917519021643, 0.1391167674102394, 0.13916046887296143]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.27453700570873707, 0.2849538418273704, 0.2765260196692814, 0.27458090586042516, 0.2754230018741792, 0.27507561898092947, 0.27541250786640414, 0.2655248641553643, 0.2757617694420596, 0.2759078217644991]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.1310283362599498, 0.12961965410548917, 0.13089563133928536, 0.13101799303024275, 0.13094350571474941, 0.13105413025811996, 0.1309687678289964, 0.13244670111303702, 0.13095744989502825, 0.13088156975419624]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.031861260561797757, 0.031902731658678546, 0.03186214563151602, 0.031861242450875016, 0.03186076747409567, 0.03186491459684502, 0.03186018808997758, 0.031908105161659026, 0.031860480914349516, 0.03188295194334326]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07436037505356735, 0.07443702203446759, 0.07530407040221626, 0.07504825029952791, 0.07443672699650672, 0.05754159303617008, 0.07443722339267538, 0.07446509808101025, 0.07443707122812038, 0.0747992940109134]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.16928251243146844, 0.16940019611560622, 0.1589678016967297, 0.16693604394210732, 0.16940072690624422, 173.3310835081715, 0.1693994792200431, 0.16817048614806004, 0.16939983039465822, 0.16503514646726813]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.020264075503835945, 0.020274594131979993, 0.020569155439883677, 0.02031256847321828, 0.02027458148097293, 0.016441180660032084, 0.02027456031025442, 0.020322505901725584, 0.02027456306191351, 0.02038881269970394]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.00745041864858885, 0.0074485639177765345, 0.007451668871959789, 0.007450052037112911, 0.007448563914315658, 0.008273018389497507, 0.007448563913431537, 0.007448437678056302, 0.007448563913247223, 0.0074503275178349915]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0011630689422144902, 0.22106914510298661, 0.2210691338840678, 0.22106913770105283, 0.2210691377996519, 0.0020829275155398114, 0.221069137675521, 0.22106912465266745, 0.22106914511346223, 0.22106913377857623]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [93.5706298672042, 0.05553423927208928, 0.05553424048702996, 0.055534239433662265, 0.05553423998035164, 460.711511118009, 0.05553423996386114, 0.05553424115730465, 0.05553423926938946, 0.05553424043790153]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08859734250578861, 999.9999999870572, 999.9999999514253, 999.9999999998896, 999.999999994851, 0.08832178150220801, 999.9999999793195, 999.9999999998763, 999.9999999973965, 999.9999999999101]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.5367134747993929, 0.0993183674990417, 0.09931836749904159, 0.09931836749904441, 0.09931836749904116, 0.5372396765884546, 0.09931836749904305, 0.09931836749904528, 0.09931836749904131, 0.09931836749904181]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14828976391920154, 0.1483356604492424, 0.14798503323998585, 0.1490937371722133, 0.14840182872892718, 0.14822181586741134, 0.14885038057762817, 0.14903263611839554, 0.14817421964439634, 0.14903216720033782]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.054762579874712024, 0.05474473067407753, 0.05482370624069295, 0.05424049347491106, 0.054742051187412336, 0.05478098123964825, 0.054630517460012615, 0.054252046708967785, 0.05477614904019722, 0.054252161920021705]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12663388547445986, 0.12665617954067654, 0.1266264678461157, 0.12883899151545877, 0.12671587959881883, 0.126726186519302, 0.1269354810557872, 0.12881405774298002, 0.12678140677007177, 0.12881393535772673]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.040182854752698685, 0.04018327808749114, 0.04018412277454137, 0.04018478585849564, 0.040181272068298454, 0.040180694547922356, 0.040183872421800215, 0.0401845034478281, 0.04018043716521562, 0.040184503449504826]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08430030781422934, 0.08430037774995375, 0.08430036866936687, 0.08430035897698927, 0.08430035621461948, 0.08430034274896674, 0.08430035491782215, 0.0843003327794982, 0.08430037338189834, 0.08430034016373823]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05412915758671947, 0.054129143632696164, 0.05412914448153982, 0.05412914768332539, 0.054129148951724784, 0.0541291506861551, 0.05412914726353322, 0.054129152327057936, 0.05412914426183218, 0.05412915190846893]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [999.9999998721331, 999.9999988626233, 999.9999999268645, 999.9999999581008, 999.999998392451, 999.9999996993558, 999.9999998608826, 999.9999999998728, 999.9999999189961, 999.9999977271059]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1458908359091616, 0.14589083590905721, 0.14589083590912394, 0.1458908359092176, 0.14589083590919066, 0.14589083590916613, 0.14589083590906995, 0.1458908359091734, 0.14589083590907928, 0.1458908359090948]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1332739413860922, 0.13327450840552188, 0.13327409098283813, 0.13327427227064745, 0.0020473863551791595, 0.1328949636062283, 0.13327392204317762, 0.13289504555800769, 0.1332740171004246, 0.1328952418387591]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19735982400107102, 0.19735911755400204, 0.19735963114146649, 0.19735940576415517, 4.537257653656653, 0.19900653079368896, 0.19735983732596896, 0.1990064155584879, 0.19735972341785318, 0.1990061444910501]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10853689744092339, 0.10853696801049226, 0.10853691245307842, 0.10853693528059902, 0.08396566444590167, 0.10827361831177093, 0.10853688922153729, 0.10827362271419873, 0.10853690335130634, 0.10827363584434666]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.25885734650720643, 0.2588573465086307, 0.25885734650737563, 0.2588573465076609, 0.28740532209973224, 0.25885804033561943, 0.2588573465079799, 0.2588580403355452, 0.2588573465066859, 0.2588580403356153]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12380948767823123, 0.1238094145598743, 0.1238095182291284, 0.1233297959626745, 0.12380950421327185, 0.12391655763859713, 0.15810350153858807, 0.123743146702017, 0.12332979642154858, 0.12332975427190758]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04303161973936419, 0.043031636681335396, 0.043031608373383, 0.043521169194966035, 0.04303160837803432, 0.04299986270025447, 0.027433063802177884, 0.04302279571119958, 0.04352116717558906, 0.043521181361618144]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07299522900201687, 0.07299521658383627, 0.07299522733112966, 0.07139561931785986, 0.07299521922627324, 0.07306644152702906, 306.6945687740285, 0.0730755500451832, 0.07139561623848342, 0.0713956158593473]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0029152929592282644, 0.002915292959232122, 0.00291529295922348, 0.0029160191458655403, 0.002915292959146958, 0.0029155267267136054, 0.013341535720631835, 0.002915496492517192, 0.0029160191458860642, 0.00291601914588176]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08707009011535931, 0.08704781832200564, 0.08707623907343993, 0.08718953849924779, 0.08704781331697091, 0.08701454179409313, 0.08704779680512383, 0.08704782657848452, 0.08704780571290119, 0.08704782483555105]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.036172420392150864, 0.03617215791973824, 0.03616172356843205, 0.03604580287799593, 0.03617215887543982, 0.03618780586832674, 0.036172164517218115, 0.03617215616471199, 0.0361721609229211, 0.03617215630556514]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19313866427104703, 0.19325840164680377, 0.1932477268580154, 0.19864981541945412, 0.19325839566333133, 0.19291031031375563, 0.19325839048625018, 0.19325840981898587, 0.19325839036964382, 0.1932584068900676]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0023156482274348193, 0.0023155933407807273, 0.00231562848310746, 0.0023157518228968305, 0.0023155933407827574, 0.0023156285132839823, 0.0023155933407873405, 0.00231559334078217, 0.002315593340783853, 0.0023155933407812703]}],\n",
+       "                        '72c5acc1-948e-45b6-879f-cff7b855b242',\n",
+       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.1392851204115826, 0.14004039570205634, 0.13905237643227727, 0.13868812753481052, 0.1396645367594054, 0.13915728864434526, 0.13958613710568685, 0.13903799443532208, 0.13948556890951266, 0.13954619280890204]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.2754200383483037, 0.2740601236941595, 0.2757583816214603, 0.27653425953704647, 0.2747174785079591, 0.275630398378277, 0.2749266586622544, 0.2759065022262726, 0.27506754320574284, 0.27499060028051414]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13097592114938542, 0.13099590556403654, 0.13093181345952015, 0.13093969357496305, 0.13095644386949143, 0.1309570930550862, 0.13098116769946067, 0.1309549647144671, 0.13097003096452636, 0.13098850993927486]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.03186067573123524, 0.03186301633492758, 0.031861954163742295, 0.031861927960031254, 0.031862431367059976, 0.03186083903524911, 0.031860475916730635, 0.031860639622121344, 0.03186073888169228, 0.03186049979162137]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07455438994349883, 0.07455410906185411, 0.07451512953234525, 0.07454238463860978, 0.05752213434109045, 0.07479930631895164, 0.07455509514591267, 0.07455475544889653, 0.07443708832512272, 0.0747993087799642]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.16791181480795098, 0.16791236247627161, 0.16801192996771316, 0.16791272067891927, 999.9999976503309, 0.165035099159095, 0.16791038108629744, 0.16791128184476964, 0.16939988244893592, 0.16503510904029453]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.02031387074794752, 0.02031386516121883, 0.02031611597895983, 0.020312234490651157, 0.016438528639122305, 0.020388810031782435, 0.02031387758526599, 0.020313899734684712, 0.020274573686690212, 0.02038881190100759]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.007448217821041958, 0.0074482178246310805, 0.007448272542574417, 0.007448526934921553, 0.008274993986078791, 0.00745032751780821, 0.007448217820574983, 0.007448217820500015, 0.007448563914002162, 0.007450327517829286]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.221069126632069, 0.2210691372133391, 0.2210691339760097, 0.22106913375685563, 0.004974283603890213, 0.2210691376322354, 0.22106914515163315, 0.2210691395905615, 0.22106913741914241, 0.22106913223034524]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05553424116377097, 0.055534239543550024, 0.05553424046952728, 0.055534240444379226, 608.0694830701036, 0.055534240070064675, 0.055534239074257176, 0.05553424015931904, 0.05553423996141367, 0.055534240335311104]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [999.9999999998328, 999.999999995478, 999.9999999626199, 999.9999999759995, 0.08806177670775409, 999.9999999729192, 999.9999999947364, 999.9999999648057, 999.999999999116, 999.9999999973032]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.09931836749904324, 0.09931836749904487, 0.09931836749904109, 0.09931836749904271, 0.5377443689269127, 0.09931836749904117, 0.09931836749904512, 0.09931836749904417, 0.0993183674990437, 0.09931836749904165]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.15016669956620154, 0.14905104486597168, 0.1483274113739557, 0.14980578731924576, 0.14898566577627836, 0.1482010581538367, 0.14835141969502097, 0.14903790294836744, 0.14908065183212812, 0.14804268977525115]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05362103582069221, 0.054255536540699714, 0.054763868580570856, 0.05372455017806364, 0.054264312548434605, 0.054783443645536736, 0.05472974143463991, 0.05425352652068387, 0.054246780267489816, 0.05483905945557663]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13118299967284933, 0.1287927483370258, 0.1266948471137335, 0.13106912477572588, 0.12880415721419705, 0.12664205362831465, 0.12666164297435048, 0.12882230228613717, 0.12884234334529895, 0.12658937815095056]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.040188184658851864, 0.04018460673832794, 0.040181140782483686, 0.04018665916254997, 0.04018465512181828, 0.040182362903006225, 0.0401849672700523, 0.040184603230236184, 0.04018482577283232, 0.04018199003233114]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08430038081392585, 0.08430037970506372, 0.08430037155117036, 0.08430035126921527, 0.08430035841480026, 0.08430035491697263, 0.08430034100703146, 0.08430033274843024, 0.0843003557843038, 0.084300370588152]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05412914294047922, 0.05412914239653237, 0.05412914522065667, 0.054129148901242465, 0.05412914698005298, 0.05412914841863741, 0.054129151242718124, 0.0541291537250366, 0.05412914881234599, 0.05412914551012188]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [999.9999999939886, 999.9999999871807, 999.9999999998914, 999.9999998032798, 999.9999992892572, 999.9999997371256, 999.9999999964808, 999.9999999322247, 999.9999998184694, 999.9999992835808]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14589083590908689, 0.14589083590903856, 0.14589083590918286, 0.14589083590904295, 0.14589083590909893, 0.1458908359091335, 0.14589083590910354, 0.14589083590916227, 0.14589083590902818, 0.14589083590903532]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13327410368892498, 0.1332743410978899, 0.13327394889458682, 0.13327425535210488, 0.13289519010564083, 0.13327391779004494, 0.13289558459533607, 0.13327431455570943, 0.13327417652574294, 0.13289503501668934]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19735962353339268, 0.19735930493332196, 0.1973598213385605, 0.19735943147757953, 0.1990062099835243, 0.19735988699733523, 0.19900570810878687, 0.19735935824750397, 0.1973595056197694, 0.19900642321390105]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10853691851282173, 0.10853693542367951, 0.10853690211613584, 0.10853693577321798, 0.10827362922100846, 0.10853691296117403, 0.10827367916402188, 0.10853694323129867, 0.10853691265044688, 0.10827361825796838]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.25885734650706005, 0.25885734650732106, 0.25885734650780357, 0.25885734650820247, 0.2588580403357222, 0.25885734650807396, 0.2588580403381629, 0.2588573465068696, 0.25885734650768394, 0.25885804033559684]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12332979026816429, 0.12332977941174503, 0.12332979053339828, 0.12380950713647192, 0.12332978667483444, 0.12332981860536438, 0.12380952694377675, 0.12380951806079654, 0.12332978126856639, 0.12380950133916431]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0435211708650278, 0.04352117234259924, 0.04352117278851517, 0.043031610973438814, 0.04352116806988983, 0.04352116238438866, 0.04303160418372592, 0.04303160762020921, 0.043521172242730624, 0.04303161034751216]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07139561891391966, 0.0713956151982025, 0.07139562219901491, 0.07299522510163682, 0.07139561224903561, 0.07139562085269828, 0.07299522511002009, 0.07299522587262644, 0.07139561606175703, 0.07299522094757457]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.002916019145793012, 0.0029160191458414446, 0.0029160191458351943, 0.0029152929592019387, 0.0029160191458863886, 0.002916019145865676, 0.00291529295919757, 0.002915292959220924, 0.0029160191458435128, 0.002915292959267321]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704783475245334, 0.08704781996003096, 0.08703075329333192, 0.08700295149788846, 0.08703258503191778, 0.08704782418064302, 0.0870478181254243, 0.08707721921117172, 0.08704782024538392, 0.08704782843919136]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.03617215355158731, 0.036172157733910346, 0.03617158169264879, 0.03617981997071207, 0.036180030214612836, 0.03617215649669775, 0.03617215798956962, 0.03616591680727679, 0.03617215762561426, 0.03617215490947538]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19325841381028366, 0.1932584040550206, 0.19321657253276622, 0.19306142095660297, 0.1930417442287894, 0.19325840667993138, 0.1932584013559515, 0.1931868542065503, 0.19325840433497601, 0.19325840728386953]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0023155933407827795, 0.0023155933407809515, 0.0023156671210871316, 0.002315734076343765, 0.0023156103642519186, 0.002315593340780316, 0.002315593340781343, 0.0023156120564454706, 0.0023155933407800425, 0.0023155933407823224]}],\n",
        "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"visible\": [true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 40\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 94\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 95\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 136\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 140\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 155\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false]}], \"label\": \"ID: 169\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true]}], \"label\": \"ID: 170\", \"method\": \"restyle\"}], \"direction\": \"right\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"yaxis\": {\"title\": {\"text\": \"Estimates\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('b5d4473e-c05d-4fa7-bc48-611a7998b2fe');\n",
+       "var gd = document.getElementById('72c5acc1-948e-45b6-879f-cff7b855b242');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -14322,7 +14136,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 12,
+   "execution_count": 16,
    "metadata": {
     "tags": []
    },
@@ -14330,7 +14144,7 @@
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "b0d60e45c04a4520808a0f7e6c9798c0",
+       "model_id": "bc07c3ae49d64bd9bd161199b8774658",
        "version_major": 2,
        "version_minor": 0
       },
@@ -14356,7 +14170,6 @@
     "\n",
     "import os\n",
     "\n",
-    "import myokit\n",
     "import numpy as np\n",
     "import pandas as pd\n",
     "import pints\n",
@@ -14373,102 +14186,64 @@
     "n_runs = 10\n",
     "\n",
     "# Import data\n",
-    "# Get path of current working directory\n",
     "path = os.getcwd()\n",
-    "\n",
-    "# Import LXF A677 control growth data\n",
     "data = pd.read_csv(path + '/data/lxf_control_growth.csv')\n",
     "\n",
     "# Define model\n",
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - dimensionless')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=True)\n",
     "\n",
-    "# Define container for the structural model estimates\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
+    "# Define initial parameters\n",
     "n_mice = len(data['#ID'].unique())\n",
-    "n_parameters = 3\n",
-    "transf_params_log_dimless = np.empty(shape=(n_mice, n_runs, n_parameters))\n",
-    "\n",
-    "# Define container for the objective function score for the optimised parameters\n",
-    "scores_log_dimless = np.empty(shape=(n_mice, n_runs))\n",
-    "\n",
-    "# Define random starting points over many orders of magnitude\n",
-    "# Shape = (n_runs, n_parameters)\n",
+    "n_parameters = model.n_parameters()\n",
     "initial_parameters = np.random.uniform(low=1E-3, high=1E3, size=(n_runs, n_parameters))\n",
+    "log_init_params = np.log(initial_parameters)\n",
     "\n",
-    "# Find mouse parameters for LXF A677 population\n",
+    "# Create boundaries to biologically relevant values\n",
+    "boundaries = pints.RectangularBoundaries(\n",
+    "    lower=np.log([1E-3] * n_parameters), upper=np.log([1E3] * n_parameters))\n",
+    "\n",
+    "# Find parameters for each mouse\n",
+    "parameters_log_dimless = []\n",
+    "scores_log_dimless = []\n",
     "mouse_ids = data['#ID'].unique()\n",
     "for index, mouse_id in enumerate(tqdm(mouse_ids)):\n",
-    "    # Create mask for mouse with specfied ID\n",
+    "    # Get data\n",
     "    mouse_mask = data['#ID'] == mouse_id\n",
-    "\n",
-    "    # Get relevant time points\n",
     "    times = data[mouse_mask]['TIME in day'].to_numpy() / characteristic_time\n",
-    "\n",
-    "    # Get measured tumour volumes\n",
-    "    observed_volumes = data[mouse_mask]['TUMOUR VOLUME in cm^3'].to_numpy() / characteristic_volume\n",
+    "    observed_volumes = data[mouse_mask]['TUMOUR VOLUME in cm^3'].to_numpy() * characteristic_volume\n",
     "\n",
     "    # Create inverse problem\n",
     "    problem = pints.SingleOutputProblem(model, times, observed_volumes)\n",
-    "\n",
-    "    # Create sum of squares error objective function\n",
     "    error = pints.SumOfSquaresError(problem)\n",
     "\n",
-    "    # Create boundaries to biologically relevant values\n",
-    "    boundary = pints.RectangularBoundaries(lower=np.log([1E-3]*3), upper=np.log([1E3]*3))\n",
-    "\n",
     "    # Run optimisation multiple times\n",
-    "    for run_id, initial_params in enumerate(initial_parameters):\n",
-    "        # Transform parameters to log-scale\n",
-    "        log_initial_params = np.log(initial_params)\n",
-    "\n",
-    "        # Create optimisation controller with a CMA-ES optimiser\n",
-    "        optimiser = pints.OptimisationController(\n",
-    "            function=error,\n",
-    "            x0=log_initial_params,\n",
-    "            boundaries=boundary,\n",
-    "            method=pints.CMAES)\n",
-    "\n",
-    "        # Disable logging mode\n",
-    "        optimiser.set_log_to_screen(False)\n",
-    "\n",
-    "        # Parallelise optimisation\n",
-    "        optimiser.set_parallel(True)\n",
-    "\n",
-    "        # Find optimal parameters\n",
-    "        try:\n",
-    "            estimates, score = optimiser.run()\n",
-    "        except:\n",
-    "            # If inference breaks fill estimates with nan\n",
-    "            estimates = np.array([np.nan, np.nan, np.nan])\n",
-    "            score = np.nan\n",
-    "\n",
-    "        # Save estimates and score (back transformed to linear scale)\n",
-    "        transf_params_log_dimless[index, run_id, :] = np.exp(estimates)\n",
-    "        scores_log_dimless[index, run_id] = score\n",
+    "    p, s = pkpd.optimise(error, pints.CMAES, log_init_params, n_runs, boundaries)\n",
+    "    parameters_log_dimless += [p]\n",
+    "    scores_log_dimless += [s]\n",
     "\n",
     "# Transform log-dimensionless parameters back to biological parameters.\n",
     "# Initialise container for backtransformed paramters\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
-    "parameters_log_dimless = np.empty(shape=transf_params_log_dimless.shape)\n",
+    "parameters_log_dimless = np.asarray(parameters_log_dimless)\n",
+    "p = parameters_log_dimless.copy()\n",
     "\n",
     "# Transform initial volumes\n",
-    "parameters_log_dimless[:, :, 0] = transf_params_log_dimless[:, :, 0] * characteristic_volume\n",
+    "parameters_log_dimless[:, :, 0] = np.exp(p[:, :, 0]) * characteristic_volume\n",
     "\n",
     "# Transform exponential growth rate\n",
-    "# lambda_0 = a_1 / a_0 /t^c\n",
+    "# lambda_0 = a_1 / 2a_0 /t^c\n",
     "parameters_log_dimless[:, :, 1] = \\\n",
-    "    transf_params_log_dimless[:, :, 2] / 2 / transf_params_log_dimless[:, :, 1] / characteristic_time\n",
+    "    np.exp(p[:, :, 2]) / 2 / np.exp(p[:, :, 1]) / characteristic_time\n",
     "\n",
     "# Transform linear growth rate\n",
     "# lambda_1 = a_1 / a_0 /t^c\n",
     "parameters_log_dimless[:, :, 2] = \\\n",
-    "    transf_params_log_dimless[:, :, 2] * characteristic_volume / characteristic_time"
+    "    np.exp(p[:, :, 2]) * characteristic_volume / characteristic_time"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 13,
+   "execution_count": 17,
    "metadata": {},
    "outputs": [
     {
@@ -14498,16 +14273,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.14009538392319237,
-          0.14132874090928546,
-          0.13916006172522652,
-          0.13928935555328892,
-          0.13947634321413926,
-          0.13926161344902185,
-          0.14066660180834722,
-          0.13964565754155583,
-          0.1377180210412203,
-          0.14001092061923576
+          0.14132826681136745,
+          0.14026392707790714,
+          0.13973326103191444,
+          0.1393960018188551,
+          0.13944298676868283,
+          0.13922360629614328,
+          0.14054393132713167,
+          0.13932355026219365,
+          0.13939460958880656,
+          0.1391220563999655
          ]
         },
         {
@@ -14530,16 +14305,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.2740121485350179,
-          0.2655255687085716,
-          0.275908752226379,
-          0.2753019867882113,
-          0.27510858889857664,
-          0.27554230287940007,
-          0.2730224069451227,
-          0.2747000597909779,
-          0.2849528935636558,
-          0.2741744029907874
+          0.2655263011793156,
+          0.27369068710316286,
+          0.27481710879693144,
+          0.2751648360590281,
+          0.2752579013535387,
+          0.27559061205586144,
+          0.2731659547621119,
+          0.2754111721276221,
+          0.2752006160411352,
+          0.27569413402535714
          ]
         },
         {
@@ -14562,16 +14337,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13103277574215713,
-          0.13244665081140672,
-          0.13088150799331186,
-          0.1309321151216509,
-          0.13098990511444455,
-          0.1309766216937198,
-          0.13109066738177982,
-          0.13097564170496792,
-          0.1296197217504809,
-          0.13103720849751038
+          0.1324465776156094,
+          0.13104238160192014,
+          0.13107290810687788,
+          0.1309498367588193,
+          0.13101774728420446,
+          0.13098513604808126,
+          0.13105296967315833,
+          0.13096884094729533,
+          0.13094170075982864,
+          0.13094817825995583
          ]
         },
         {
@@ -14594,16 +14369,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.031862051939404015,
-          0.03190810516174541,
-          0.031882951942781526,
-          0.031863280341871,
-          0.03186054483998671,
-          0.0318603967454224,
-          0.03186542988496761,
-          0.03186226819343744,
-          0.03190273165974574,
-          0.0318617798065902
+          0.03190810516377822,
+          0.03186303842738081,
+          0.03186595463709853,
+          0.031861867039710896,
+          0.031861810766638264,
+          0.03186086898648303,
+          0.03186527166293214,
+          0.03186018809071182,
+          0.031861666428875855,
+          0.03186089423258424
          ]
         },
         {
@@ -14626,16 +14401,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07443692527866973,
-          0.07479927544753175,
-          0.07455483334096254,
-          0.07455398819645645,
-          0.07454786357661945,
-          0.07443671518114613,
-          0.07455486064649346,
-          0.07479928094353705,
-          0.07434707505461091,
-          0.07479936568738353
+          0.07476032513084784,
+          0.07479928837547009,
+          0.07443667675047252,
+          0.07444161805412604,
+          0.074548812685593,
+          0.07443749427982131,
+          0.07455552474577958,
+          0.07479929645641667,
+          0.0747992565168452,
+          0.0747835434835185
          ]
         },
         {
@@ -14658,16 +14433,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.16940003484343066,
-          0.1650352043175806,
-          0.1679110600678126,
-          0.16791297765257165,
-          0.1679888365867923,
-          0.1694006339372602,
-          0.16791090905800068,
-          0.16503519522206686,
-          0.16837588372919712,
-          0.16503501471278456
+          0.1685929599742408,
+          0.1650351589832969,
+          0.16940061842633705,
+          0.16829486796427298,
+          0.16798474985362866,
+          0.16939881910760082,
+          0.16790956767115853,
+          0.16503514937131644,
+          0.1650352323027844,
+          0.1674141752780815
          ]
         },
         {
@@ -14690,16 +14465,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.02027454982429793,
-          0.020388815026254,
-          0.020313892822428004,
-          0.020313908632270384,
-          0.02031293632453774,
-          0.020274567304585354,
-          0.020313881537120642,
-          0.02038881533427136,
-          0.020317865250750897,
-          0.020388814991606875
+          0.020259508517835374,
+          0.02038881278449418,
+          0.020274555488489332,
+          0.02032239063900369,
+          0.020311920536908522,
+          0.02027455128593336,
+          0.020313889057123478,
+          0.02038881368641084,
+          0.02038881358357573,
+          0.02030288219193083
          ]
         },
         {
@@ -14722,16 +14497,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.007448563912590143,
-          0.007450327517825956,
-          0.007448217820473241,
-          0.0074482178223130085,
-          0.007448411990731835,
-          0.007448563912927028,
-          0.00744821781951724,
-          0.007450327517855924,
-          0.007448656826718985,
-          0.007450327517922184
+          0.007449430620723637,
+          0.007450327517830565,
+          0.007448563912958233,
+          0.007448585841155153,
+          0.007448232521044076,
+          0.007448563915321766,
+          0.007448217825160393,
+          0.007450327517826612,
+          0.007450327517825126,
+          0.007448547951520002
          ]
         },
         {
@@ -14754,16 +14529,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.2209043742678485,
-          0.2209043779677929,
-          0.220904370602804,
-          0.22090437956189166,
-          0.22090437798335086,
-          0.22090436658256615,
-          0.220904389032257,
-          0.22090438151909153,
-          0.2209043757861789,
-          0.22090437118537742
+          0.22090438248864447,
+          0.2209043667909061,
+          0.22090437792205248,
+          0.22090438352571343,
+          0.22090438723449216,
+          0.22090436662553975,
+          0.22090437373292768,
+          0.22090437540757765,
+          0.22090438169610072,
+          0.22090437145527247
          ]
         },
         {
@@ -14786,16 +14561,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05559246482489982,
-          0.05559246504212527,
-          0.05559246582731921,
-          0.055592464705139566,
-          0.055592464963255706,
-          0.05559246621134355,
-          0.05559246349886628,
-          0.05559246468000918,
-          0.05559246501923869,
-          0.05559246588611871
+          0.055592464295316266,
+          0.05559246626060265,
+          0.0555924645365143,
+          0.05559246423576837,
+          0.05559246387922858,
+          0.055592466863425165,
+          0.05559246547328869,
+          0.05559246563504535,
+          0.05559246450218942,
+          0.05559246595277654
          ]
         },
         {
@@ -14818,16 +14593,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          111.18492964924246,
-          111.18493008424903,
-          111.18493165429108,
-          111.18492940966999,
-          111.18492992644472,
-          111.18493242222866,
-          111.18492699748833,
-          111.18492935999612,
-          111.18493003607698,
-          111.18493177085594
+          111.18492858747688,
+          111.18493252036075,
+          111.1849290727724,
+          111.18492847133447,
+          111.18492775834643,
+          111.1849337266437,
+          111.18493094632356,
+          111.1849312696136,
+          111.18492900354485,
+          111.18493190483285
          ]
         },
         {
@@ -14850,16 +14625,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.09948736196066292,
-          0.09948736196065294,
-          0.09948736196065486,
-          0.09948736196065175,
-          0.09948736196065519,
-          0.09948736196066046,
-          0.09948736196066435,
-          0.09948736196065316,
-          0.09948736196065973,
-          0.09948736196066715
+          0.099487361960662,
+          0.09948736196065722,
+          0.09948736196065594,
+          0.0994873619606666,
+          0.09948736196066557,
+          0.09948736196065938,
+          0.09948736196065694,
+          0.09948736196065772,
+          0.09948736196065755,
+          0.09948736196066202
          ]
         },
         {
@@ -14882,16 +14657,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14903260605053983,
-          0.14834299973697745,
-          0.14896583997664534,
-          0.14968793229104954,
-          0.1496566294310111,
-          0.14957785469790844,
-          0.14903301494924978,
-          0.14810476906379705,
-          0.14815634385012513,
-          0.1482973879192343
+          0.14903267681527432,
+          0.1481953996506983,
+          0.14888205612247588,
+          0.14809906543165113,
+          0.14761387264838816,
+          0.14832985850836344,
+          0.14842750707818558,
+          0.1490147410182993,
+          0.14900367588655236,
+          0.14848606163115963
          ]
         },
         {
@@ -14914,16 +14689,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.054252064523064775,
-          0.054758051011878764,
-          0.05426666306198315,
-          0.053747047130459545,
-          0.05375430972529993,
-          0.05377860525956875,
-          0.05425194903653683,
-          0.054824281304141735,
-          0.05481386121024495,
-          0.05476756979927114
+          0.05425203729779796,
+          0.05477898986519114,
+          0.054292621293151565,
+          0.054824527373859885,
+          0.05494686656885088,
+          0.054773688034379965,
+          0.05475336156259726,
+          0.05425289992651349,
+          0.05426844194011933,
+          0.054738902350398445
          ]
         },
         {
@@ -14946,16 +14721,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12881407463593128,
-          0.12678171331655982,
-          0.12879541652620402,
-          0.13100519520398504,
-          0.13100339799336683,
-          0.13093578195778352,
-          0.12881414566836613,
-          0.12667372984453834,
-          0.12677183741682108,
-          0.12676769317177183
+          0.1288140697528396,
+          0.12678841803243335,
+          0.12878359130496192,
+          0.12659881231174078,
+          0.12659688565308183,
+          0.1268000870346152,
+          0.1268210711663224,
+          0.12880155440327218,
+          0.128783240225505,
+          0.12689489261985867
          ]
         },
         {
@@ -14978,16 +14753,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.040184503448467516,
-          0.04018065439788209,
-          0.04018515854099618,
-          0.0401864189812734,
-          0.04018650825457161,
-          0.04018637925511816,
-          0.04018450344903002,
-          0.04018111200058634,
-          0.04018150383677363,
-          0.04018053419382228
+          0.04018450344745786,
+          0.0401801432625508,
+          0.04018481155785493,
+          0.04018185642069494,
+          0.04018445389366164,
+          0.04018184352732887,
+          0.0401827052098233,
+          0.040184690623741734,
+          0.04018465547219967,
+          0.04018433316478385
          ]
         },
         {
@@ -15010,16 +14785,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08417666585691294,
-          0.08417659978254784,
-          0.08417664272857985,
-          0.08417664547635051,
-          0.08417663711022955,
-          0.08417665997451756,
-          0.0841766444931603,
-          0.08417663522974711,
-          0.08417664275251685,
-          0.08417665560057744
+          0.08417663164878192,
+          0.08417662608912305,
+          0.08417663705092393,
+          0.08417664878337859,
+          0.08417663801619035,
+          0.08417665001516451,
+          0.0841766150003069,
+          0.08417663524634066,
+          0.08417665473463812,
+          0.08417665478416864
          ]
         },
         {
@@ -15042,16 +14817,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05418267911369396,
-          0.054182692263506395,
-          0.05418268385103066,
-          0.05418268254039129,
-          0.05418268437390086,
-          0.054182680095108196,
-          0.054182682500966514,
-          0.05418268436831403,
-          0.05418268449040265,
-          0.05418268097551668
+          0.05418268530383352,
+          0.054182687459527805,
+          0.0541826837972153,
+          0.054182682506464096,
+          0.05418268528245516,
+          0.05418268158363944,
+          0.05418269035334832,
+          0.05418268500668379,
+          0.0541826801190752,
+          0.05418268014904978
          ]
         },
         {
@@ -15074,16 +14849,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          108.36535819156293,
-          108.3653845131421,
-          108.36536767074256,
-          108.36536507609182,
-          108.36536873958205,
-          108.36536016098333,
-          108.3653649953898,
-          108.36536872565684,
-          108.36536896194524,
-          108.3653619494643
+          108.36537059521592,
+          108.36537491722639,
+          108.3653675930294,
+          108.3653650070198,
+          108.36537056150311,
+          108.36536316472231,
+          108.36538070383612,
+          108.36537001061112,
+          108.3653602047164,
+          108.36536029806162
          ]
         },
         {
@@ -15106,16 +14881,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14604315833674597,
-          0.1460431583366912,
-          0.14604315833663184,
-          0.14604315833670387,
-          0.1460431583367627,
-          0.14604315833674292,
-          0.14604315833671055,
-          0.14604315833671463,
-          0.1460431583366511,
-          0.14604315833663353
+          0.14604315833670806,
+          0.14604315833670156,
+          0.14604315833675052,
+          0.14604315833668455,
+          0.14604315833670492,
+          0.14604315833674666,
+          0.1460431583367935,
+          0.1460431583366932,
+          0.1460431583367286,
+          0.14604315833664477
          ]
         },
         {
@@ -15138,16 +14913,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.13289529230280872,
-          0.13327423565475274,
-          0.13327400777151405,
-          0.13035829869641372,
-          0.13327437523672742,
-          0.13327440497374868,
-          0.13289508659864235,
-          0.1332743015295498,
-          0.132895358668628,
-          0.13327431613191384
+          0.13327384150925822,
+          0.13327438350607704,
+          0.13327446980574692,
+          0.13327405056207964,
+          0.13327419822514758,
+          0.13327410197872183,
+          0.13327411121901253,
+          0.1332738659984612,
+          0.13327415466773082,
+          0.13327512266513739
          ]
         },
         {
@@ -15170,16 +14945,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1990061108048667,
-          0.19735941141793897,
-          0.19735972791745912,
-          0.2069590488500953,
-          0.19735926437667028,
-          0.19735921875338686,
-          0.19900635585086637,
-          0.19735937080348712,
-          0.19900600592640844,
-          0.19735937147998958
+          0.19735994624297207,
+          0.19735922714553192,
+          0.1973591392710216,
+          0.1973596874103613,
+          0.19735950856827436,
+          0.19735961879077732,
+          0.19735959049141055,
+          0.1973599251722135,
+          0.1973595423495407,
+          0.19735835271791569
          ]
         },
         {
@@ -15202,16 +14977,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.10827365893515474,
-          0.10853690864531433,
-          0.10853689828354324,
-          0.106880097453979,
-          0.10853694078886271,
-          0.10853693980385645,
-          0.10827362378711348,
-          0.10853693968652757,
-          0.10827365615125616,
-          0.10853695180539086
+          0.10853688380034879,
+          0.1085369269523682,
+          0.10853694844513384,
+          0.10853691064277508,
+          0.10853693178935696,
+          0.10853691453143252,
+          0.10853690647528097,
+          0.10853689200883028,
+          0.10853691510331635,
+          0.10853704431837709
          ]
         },
         {
@@ -15234,16 +15009,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.25885804033592824,
-          0.2588573465081154,
-          0.25885734650758746,
-          0.2588923112435427,
-          0.25885734650699055,
-          0.2588573465079774,
-          0.2588580403355425,
-          0.2588573465076428,
-          0.25885804033584564,
-          0.2588573465074839
+          0.25885734650788306,
+          0.2588573465076871,
+          0.2588573465077157,
+          0.25885734650734965,
+          0.25885734650760495,
+          0.2588573465072246,
+          0.2588573465077381,
+          0.2588573465075452,
+          0.2588573465074996,
+          0.2588573465130012
          ]
         },
         {
@@ -15266,16 +15041,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12380948221062264,
-          0.12332981826499963,
-          0.123329868254266,
-          0.12332981156914442,
-          0.12332980605532579,
-          0.12332974327720274,
-          0.12380952562876646,
-          0.12380948841016408,
-          0.12332976438376764,
-          0.1238094881198356
+          0.12380948019972607,
+          0.12380952353648071,
+          0.12332976855147042,
+          0.12332981446005441,
+          0.12310319698678361,
+          0.12380940079232614,
+          0.12380947520900795,
+          0.12380954661221352,
+          0.12380960962351067,
+          0.12380946801293331
          ]
         },
         {
@@ -15298,16 +15073,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.04303161383864064,
-          0.04352116152062167,
-          0.043521144996799196,
-          0.043521164349000774,
-          0.04352116494858105,
-          0.04352118453199113,
-          0.04303160259267315,
-          0.043031619072486794,
-          0.043521178810544826,
-          0.0430316178167303
+          0.04303162069752749,
+          0.04303160431116223,
+          0.043521174995628506,
+          0.043521160574381025,
+          0.043636532208813285,
+          0.0430316464858177,
+          0.04303161525517645,
+          0.043031598108170754,
+          0.04303158110720427,
+          0.04303162180186407
          ]
         },
         {
@@ -15330,16 +15105,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07299521610273974,
-          0.07139561927698623,
-          0.07139562024975481,
-          0.07139562017520228,
-          0.07139561805142215,
-          0.07139561492603894,
-          0.07299522142877628,
-          0.07299522823999481,
-          0.0713956173455878,
-          0.07299522620615467
+          0.07299522647176616,
+          0.07299522310396486,
+          0.07139561347488436,
+          0.0713956155621438,
+          0.07110775002877251,
+          0.0729952251708708,
+          0.07299521429474437,
+          0.0729952256044808,
+          0.07299523227812073,
+          0.07299522142671035
          ]
         },
         {
@@ -15362,16 +15137,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.002915292959207903,
-          0.002916019145870083,
-          0.002916019145897346,
-          0.002916019145838842,
-          0.002916019145836455,
-          0.0029160191458536293,
-          0.002915292959162006,
-          0.0029152929591781296,
-          0.0029160191458579756,
-          0.0029152929592452213
+          0.002915292959196112,
+          0.0029152929591758567,
+          0.002916019145838786,
+          0.0029160191458570787,
+          0.00291662425369751,
+          0.0029152929593568738,
+          0.002915292959201513,
+          0.0029152929591963663,
+          0.0029152929591884508,
+          0.002915292959168399
          ]
         },
         {
@@ -15394,16 +15169,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08704782850270609,
-          0.08704782546495617,
-          0.0870478252290391,
-          0.08704783529753318,
-          0.08704781239591003,
-          0.08704781616330665,
-          0.08718953886680342,
-          0.08704782600965753,
-          0.0870478275151138,
-          0.08704781581863295
+          0.08704782467991515,
+          0.08705842825652134,
+          0.08704782068140157,
+          0.08704781526346031,
+          0.08704781463848625,
+          0.08704781511282772,
+          0.08710915731312975,
+          0.08698594161907236,
+          0.08704783015293224,
+          0.08710915450222266
          ]
         },
         {
@@ -15426,16 +15201,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.03617215521377181,
-          0.03617215623831548,
-          0.03617215600523997,
-          0.03617215365491004,
-          0.0361721592145521,
-          0.03617215824053547,
-          0.036045801521247874,
-          0.03617215458583041,
-          0.0361721552541511,
-          0.03617215868003003
+          0.03617215578160189,
+          0.03616885189141887,
+          0.03617215820823225,
+          0.036172156828456495,
+          0.03617215972943457,
+          0.0361721588866778,
+          0.036118342212931066,
+          0.03619867500866847,
+          0.036172154049503365,
+          0.03611834217380243
          ]
         },
         {
@@ -15458,16 +15233,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1932584092658417,
-          0.19325840777462192,
-          0.19325840627935317,
-          0.19325841552652678,
-          0.19325839545524567,
-          0.19325839855267044,
-          0.1986498085007782,
-          0.19325840036357234,
-          0.19325840710194228,
-          0.19325840011662931
+          0.19325840407043118,
+          0.19323033254457087,
+          0.19325840819582601,
+          0.19325838911913715,
+          0.19325840330634525,
+          0.19325839986467566,
+          0.19534757512856316,
+          0.19294290259084218,
+          0.19325840629622854,
+          0.1953475691281679
          ]
         },
         {
@@ -15490,16 +15265,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.002315593340781038,
-          0.0023155933407824868,
-          0.0023155933407809823,
-          0.0023155933407828164,
-          0.0023155933407827903,
-          0.0023155933407814668,
-          0.002315751822893314,
-          0.0023155933407863344,
-          0.002315593340782051,
-          0.0023155933407812534
+          0.002315593340780892,
+          0.002315599666594332,
+          0.002315593340781952,
+          0.0023155933408039136,
+          0.0023155933407821173,
+          0.0023155933407812547,
+          0.0023157352352735487,
+          0.002315714109493192,
+          0.0023155933407843676,
+          0.0023157352352759777
          ]
         }
        ],
@@ -16680,20 +16455,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"7dde4cbd-bbf8-4355-8f19-8daf6c5caf22\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"0ce7051b-2bde-4f69-8541-a4e6034a5d83\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"7dde4cbd-bbf8-4355-8f19-8daf6c5caf22\")) {\n",
+       "                if (document.getElementById(\"0ce7051b-2bde-4f69-8541-a4e6034a5d83\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        '7dde4cbd-bbf8-4355-8f19-8daf6c5caf22',\n",
-       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.14009538392319237, 0.14132874090928546, 0.13916006172522652, 0.13928935555328892, 0.13947634321413926, 0.13926161344902185, 0.14066660180834722, 0.13964565754155583, 0.1377180210412203, 0.14001092061923576]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.2740121485350179, 0.2655255687085716, 0.275908752226379, 0.2753019867882113, 0.27510858889857664, 0.27554230287940007, 0.2730224069451227, 0.2747000597909779, 0.2849528935636558, 0.2741744029907874]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13103277574215713, 0.13244665081140672, 0.13088150799331186, 0.1309321151216509, 0.13098990511444455, 0.1309766216937198, 0.13109066738177982, 0.13097564170496792, 0.1296197217504809, 0.13103720849751038]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.031862051939404015, 0.03190810516174541, 0.031882951942781526, 0.031863280341871, 0.03186054483998671, 0.0318603967454224, 0.03186542988496761, 0.03186226819343744, 0.03190273165974574, 0.0318617798065902]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07443692527866973, 0.07479927544753175, 0.07455483334096254, 0.07455398819645645, 0.07454786357661945, 0.07443671518114613, 0.07455486064649346, 0.07479928094353705, 0.07434707505461091, 0.07479936568738353]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.16940003484343066, 0.1650352043175806, 0.1679110600678126, 0.16791297765257165, 0.1679888365867923, 0.1694006339372602, 0.16791090905800068, 0.16503519522206686, 0.16837588372919712, 0.16503501471278456]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.02027454982429793, 0.020388815026254, 0.020313892822428004, 0.020313908632270384, 0.02031293632453774, 0.020274567304585354, 0.020313881537120642, 0.02038881533427136, 0.020317865250750897, 0.020388814991606875]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.007448563912590143, 0.007450327517825956, 0.007448217820473241, 0.0074482178223130085, 0.007448411990731835, 0.007448563912927028, 0.00744821781951724, 0.007450327517855924, 0.007448656826718985, 0.007450327517922184]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2209043742678485, 0.2209043779677929, 0.220904370602804, 0.22090437956189166, 0.22090437798335086, 0.22090436658256615, 0.220904389032257, 0.22090438151909153, 0.2209043757861789, 0.22090437118537742]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05559246482489982, 0.05559246504212527, 0.05559246582731921, 0.055592464705139566, 0.055592464963255706, 0.05559246621134355, 0.05559246349886628, 0.05559246468000918, 0.05559246501923869, 0.05559246588611871]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [111.18492964924246, 111.18493008424903, 111.18493165429108, 111.18492940966999, 111.18492992644472, 111.18493242222866, 111.18492699748833, 111.18492935999612, 111.18493003607698, 111.18493177085594]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.09948736196066292, 0.09948736196065294, 0.09948736196065486, 0.09948736196065175, 0.09948736196065519, 0.09948736196066046, 0.09948736196066435, 0.09948736196065316, 0.09948736196065973, 0.09948736196066715]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14903260605053983, 0.14834299973697745, 0.14896583997664534, 0.14968793229104954, 0.1496566294310111, 0.14957785469790844, 0.14903301494924978, 0.14810476906379705, 0.14815634385012513, 0.1482973879192343]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.054252064523064775, 0.054758051011878764, 0.05426666306198315, 0.053747047130459545, 0.05375430972529993, 0.05377860525956875, 0.05425194903653683, 0.054824281304141735, 0.05481386121024495, 0.05476756979927114]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12881407463593128, 0.12678171331655982, 0.12879541652620402, 0.13100519520398504, 0.13100339799336683, 0.13093578195778352, 0.12881414566836613, 0.12667372984453834, 0.12677183741682108, 0.12676769317177183]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.040184503448467516, 0.04018065439788209, 0.04018515854099618, 0.0401864189812734, 0.04018650825457161, 0.04018637925511816, 0.04018450344903002, 0.04018111200058634, 0.04018150383677363, 0.04018053419382228]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08417666585691294, 0.08417659978254784, 0.08417664272857985, 0.08417664547635051, 0.08417663711022955, 0.08417665997451756, 0.0841766444931603, 0.08417663522974711, 0.08417664275251685, 0.08417665560057744]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05418267911369396, 0.054182692263506395, 0.05418268385103066, 0.05418268254039129, 0.05418268437390086, 0.054182680095108196, 0.054182682500966514, 0.05418268436831403, 0.05418268449040265, 0.05418268097551668]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [108.36535819156293, 108.3653845131421, 108.36536767074256, 108.36536507609182, 108.36536873958205, 108.36536016098333, 108.3653649953898, 108.36536872565684, 108.36536896194524, 108.3653619494643]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14604315833674597, 0.1460431583366912, 0.14604315833663184, 0.14604315833670387, 0.1460431583367627, 0.14604315833674292, 0.14604315833671055, 0.14604315833671463, 0.1460431583366511, 0.14604315833663353]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13289529230280872, 0.13327423565475274, 0.13327400777151405, 0.13035829869641372, 0.13327437523672742, 0.13327440497374868, 0.13289508659864235, 0.1332743015295498, 0.132895358668628, 0.13327431613191384]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1990061108048667, 0.19735941141793897, 0.19735972791745912, 0.2069590488500953, 0.19735926437667028, 0.19735921875338686, 0.19900635585086637, 0.19735937080348712, 0.19900600592640844, 0.19735937147998958]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10827365893515474, 0.10853690864531433, 0.10853689828354324, 0.106880097453979, 0.10853694078886271, 0.10853693980385645, 0.10827362378711348, 0.10853693968652757, 0.10827365615125616, 0.10853695180539086]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.25885804033592824, 0.2588573465081154, 0.25885734650758746, 0.2588923112435427, 0.25885734650699055, 0.2588573465079774, 0.2588580403355425, 0.2588573465076428, 0.25885804033584564, 0.2588573465074839]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12380948221062264, 0.12332981826499963, 0.123329868254266, 0.12332981156914442, 0.12332980605532579, 0.12332974327720274, 0.12380952562876646, 0.12380948841016408, 0.12332976438376764, 0.1238094881198356]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04303161383864064, 0.04352116152062167, 0.043521144996799196, 0.043521164349000774, 0.04352116494858105, 0.04352118453199113, 0.04303160259267315, 0.043031619072486794, 0.043521178810544826, 0.0430316178167303]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07299521610273974, 0.07139561927698623, 0.07139562024975481, 0.07139562017520228, 0.07139561805142215, 0.07139561492603894, 0.07299522142877628, 0.07299522823999481, 0.0713956173455878, 0.07299522620615467]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.002915292959207903, 0.002916019145870083, 0.002916019145897346, 0.002916019145838842, 0.002916019145836455, 0.0029160191458536293, 0.002915292959162006, 0.0029152929591781296, 0.0029160191458579756, 0.0029152929592452213]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704782850270609, 0.08704782546495617, 0.0870478252290391, 0.08704783529753318, 0.08704781239591003, 0.08704781616330665, 0.08718953886680342, 0.08704782600965753, 0.0870478275151138, 0.08704781581863295]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.03617215521377181, 0.03617215623831548, 0.03617215600523997, 0.03617215365491004, 0.0361721592145521, 0.03617215824053547, 0.036045801521247874, 0.03617215458583041, 0.0361721552541511, 0.03617215868003003]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1932584092658417, 0.19325840777462192, 0.19325840627935317, 0.19325841552652678, 0.19325839545524567, 0.19325839855267044, 0.1986498085007782, 0.19325840036357234, 0.19325840710194228, 0.19325840011662931]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.002315593340781038, 0.0023155933407824868, 0.0023155933407809823, 0.0023155933407828164, 0.0023155933407827903, 0.0023155933407814668, 0.002315751822893314, 0.0023155933407863344, 0.002315593340782051, 0.0023155933407812534]}],\n",
+       "                        '0ce7051b-2bde-4f69-8541-a4e6034a5d83',\n",
+       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.14132826681136745, 0.14026392707790714, 0.13973326103191444, 0.1393960018188551, 0.13944298676868283, 0.13922360629614328, 0.14054393132713167, 0.13932355026219365, 0.13939460958880656, 0.1391220563999655]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.2655263011793156, 0.27369068710316286, 0.27481710879693144, 0.2751648360590281, 0.2752579013535387, 0.27559061205586144, 0.2731659547621119, 0.2754111721276221, 0.2752006160411352, 0.27569413402535714]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.1324465776156094, 0.13104238160192014, 0.13107290810687788, 0.1309498367588193, 0.13101774728420446, 0.13098513604808126, 0.13105296967315833, 0.13096884094729533, 0.13094170075982864, 0.13094817825995583]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.03190810516377822, 0.03186303842738081, 0.03186595463709853, 0.031861867039710896, 0.031861810766638264, 0.03186086898648303, 0.03186527166293214, 0.03186018809071182, 0.031861666428875855, 0.03186089423258424]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07476032513084784, 0.07479928837547009, 0.07443667675047252, 0.07444161805412604, 0.074548812685593, 0.07443749427982131, 0.07455552474577958, 0.07479929645641667, 0.0747992565168452, 0.0747835434835185]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1685929599742408, 0.1650351589832969, 0.16940061842633705, 0.16829486796427298, 0.16798474985362866, 0.16939881910760082, 0.16790956767115853, 0.16503514937131644, 0.1650352323027844, 0.1674141752780815]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.020259508517835374, 0.02038881278449418, 0.020274555488489332, 0.02032239063900369, 0.020311920536908522, 0.02027455128593336, 0.020313889057123478, 0.02038881368641084, 0.02038881358357573, 0.02030288219193083]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.007449430620723637, 0.007450327517830565, 0.007448563912958233, 0.007448585841155153, 0.007448232521044076, 0.007448563915321766, 0.007448217825160393, 0.007450327517826612, 0.007450327517825126, 0.007448547951520002]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.22090438248864447, 0.2209043667909061, 0.22090437792205248, 0.22090438352571343, 0.22090438723449216, 0.22090436662553975, 0.22090437373292768, 0.22090437540757765, 0.22090438169610072, 0.22090437145527247]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.055592464295316266, 0.05559246626060265, 0.0555924645365143, 0.05559246423576837, 0.05559246387922858, 0.055592466863425165, 0.05559246547328869, 0.05559246563504535, 0.05559246450218942, 0.05559246595277654]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [111.18492858747688, 111.18493252036075, 111.1849290727724, 111.18492847133447, 111.18492775834643, 111.1849337266437, 111.18493094632356, 111.1849312696136, 111.18492900354485, 111.18493190483285]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.099487361960662, 0.09948736196065722, 0.09948736196065594, 0.0994873619606666, 0.09948736196066557, 0.09948736196065938, 0.09948736196065694, 0.09948736196065772, 0.09948736196065755, 0.09948736196066202]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14903267681527432, 0.1481953996506983, 0.14888205612247588, 0.14809906543165113, 0.14761387264838816, 0.14832985850836344, 0.14842750707818558, 0.1490147410182993, 0.14900367588655236, 0.14848606163115963]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05425203729779796, 0.05477898986519114, 0.054292621293151565, 0.054824527373859885, 0.05494686656885088, 0.054773688034379965, 0.05475336156259726, 0.05425289992651349, 0.05426844194011933, 0.054738902350398445]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1288140697528396, 0.12678841803243335, 0.12878359130496192, 0.12659881231174078, 0.12659688565308183, 0.1268000870346152, 0.1268210711663224, 0.12880155440327218, 0.128783240225505, 0.12689489261985867]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04018450344745786, 0.0401801432625508, 0.04018481155785493, 0.04018185642069494, 0.04018445389366164, 0.04018184352732887, 0.0401827052098233, 0.040184690623741734, 0.04018465547219967, 0.04018433316478385]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08417663164878192, 0.08417662608912305, 0.08417663705092393, 0.08417664878337859, 0.08417663801619035, 0.08417665001516451, 0.0841766150003069, 0.08417663524634066, 0.08417665473463812, 0.08417665478416864]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05418268530383352, 0.054182687459527805, 0.0541826837972153, 0.054182682506464096, 0.05418268528245516, 0.05418268158363944, 0.05418269035334832, 0.05418268500668379, 0.0541826801190752, 0.05418268014904978]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [108.36537059521592, 108.36537491722639, 108.3653675930294, 108.3653650070198, 108.36537056150311, 108.36536316472231, 108.36538070383612, 108.36537001061112, 108.3653602047164, 108.36536029806162]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14604315833670806, 0.14604315833670156, 0.14604315833675052, 0.14604315833668455, 0.14604315833670492, 0.14604315833674666, 0.1460431583367935, 0.1460431583366932, 0.1460431583367286, 0.14604315833664477]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13327384150925822, 0.13327438350607704, 0.13327446980574692, 0.13327405056207964, 0.13327419822514758, 0.13327410197872183, 0.13327411121901253, 0.1332738659984612, 0.13327415466773082, 0.13327512266513739]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19735994624297207, 0.19735922714553192, 0.1973591392710216, 0.1973596874103613, 0.19735950856827436, 0.19735961879077732, 0.19735959049141055, 0.1973599251722135, 0.1973595423495407, 0.19735835271791569]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10853688380034879, 0.1085369269523682, 0.10853694844513384, 0.10853691064277508, 0.10853693178935696, 0.10853691453143252, 0.10853690647528097, 0.10853689200883028, 0.10853691510331635, 0.10853704431837709]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.25885734650788306, 0.2588573465076871, 0.2588573465077157, 0.25885734650734965, 0.25885734650760495, 0.2588573465072246, 0.2588573465077381, 0.2588573465075452, 0.2588573465074996, 0.2588573465130012]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12380948019972607, 0.12380952353648071, 0.12332976855147042, 0.12332981446005441, 0.12310319698678361, 0.12380940079232614, 0.12380947520900795, 0.12380954661221352, 0.12380960962351067, 0.12380946801293331]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04303162069752749, 0.04303160431116223, 0.043521174995628506, 0.043521160574381025, 0.043636532208813285, 0.0430316464858177, 0.04303161525517645, 0.043031598108170754, 0.04303158110720427, 0.04303162180186407]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07299522647176616, 0.07299522310396486, 0.07139561347488436, 0.0713956155621438, 0.07110775002877251, 0.0729952251708708, 0.07299521429474437, 0.0729952256044808, 0.07299523227812073, 0.07299522142671035]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.002915292959196112, 0.0029152929591758567, 0.002916019145838786, 0.0029160191458570787, 0.00291662425369751, 0.0029152929593568738, 0.002915292959201513, 0.0029152929591963663, 0.0029152929591884508, 0.002915292959168399]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704782467991515, 0.08705842825652134, 0.08704782068140157, 0.08704781526346031, 0.08704781463848625, 0.08704781511282772, 0.08710915731312975, 0.08698594161907236, 0.08704783015293224, 0.08710915450222266]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.03617215578160189, 0.03616885189141887, 0.03617215820823225, 0.036172156828456495, 0.03617215972943457, 0.0361721588866778, 0.036118342212931066, 0.03619867500866847, 0.036172154049503365, 0.03611834217380243]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19325840407043118, 0.19323033254457087, 0.19325840819582601, 0.19325838911913715, 0.19325840330634525, 0.19325839986467566, 0.19534757512856316, 0.19294290259084218, 0.19325840629622854, 0.1953475691281679]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.002315593340780892, 0.002315599666594332, 0.002315593340781952, 0.0023155933408039136, 0.0023155933407821173, 0.0023155933407812547, 0.0023157352352735487, 0.002315714109493192, 0.0023155933407843676, 0.0023157352352759777]}],\n",
        "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"visible\": [true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 40\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 94\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 95\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 136\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 140\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 155\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false]}], \"label\": \"ID: 169\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true]}], \"label\": \"ID: 170\", \"method\": \"restyle\"}], \"direction\": \"right\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"yaxis\": {\"title\": {\"text\": \"Estimates\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('7dde4cbd-bbf8-4355-8f19-8daf6c5caf22');\n",
+       "var gd = document.getElementById('0ce7051b-2bde-4f69-8541-a4e6034a5d83');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -16778,9 +16553,16 @@
     "We now have a good idea for reasonable parameter values $\\psi $ for all mice. The ultimate identifiability test is now to simulate data with the inferred parameters and check whether we can recover the exact same parameters."
    ]
   },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Synthesize data"
+   ]
+  },
   {
    "cell_type": "code",
-   "execution_count": 14,
+   "execution_count": 18,
    "metadata": {
     "tags": []
    },
@@ -16802,13 +16584,8 @@
     "\n",
     "\n",
     "# Import data\n",
-    "# Get path of current working directory\n",
     "path = os.getcwd()\n",
-    "\n",
-    "# Import LXF A677 control growth data\n",
     "data = pd.read_csv(path + '/data/lxf_control_growth.csv')\n",
-    "\n",
-    "# Get mouse IDs and times\n",
     "mouse_ids_and_times = data[['#ID', 'TIME in day']]\n",
     "\n",
     "# Get median parameters for each mouse\n",
@@ -16818,19 +16595,13 @@
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - Eigenmann et. al.')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=False)\n",
     "\n",
-    "# Create container for simulated synthesised data\n",
-    "simulated_data = []\n",
-    "\n",
     "# Simulate \"noise-free\" data\n",
+    "simulated_data = []\n",
     "mouse_ids = mouse_ids_and_times['#ID'].unique()\n",
     "for index, mouse_id in enumerate(mouse_ids):\n",
-    "    # Create mask for mouse\n",
+    "    # Get times and parameters\n",
     "    mask = mouse_ids_and_times['#ID'] == mouse_id\n",
-    "\n",
-    "    # Get times\n",
     "    times = mouse_ids_and_times[mask]['TIME in day'].to_numpy()\n",
-    "\n",
-    "    # Get parameters\n",
     "    parameters = median_parameters[index, :]\n",
     "\n",
     "    # Simulate data\n",
@@ -16847,15 +16618,22 @@
     "simulated_data = pd.concat(simulated_data)\n"
    ]
   },
+  {
+   "cell_type": "markdown",
+   "metadata": {},
+   "source": [
+    "### Run optimisation"
+   ]
+  },
   {
    "cell_type": "code",
-   "execution_count": 15,
+   "execution_count": 22,
    "metadata": {},
    "outputs": [
     {
      "data": {
       "application/vnd.jupyter.widget-view+json": {
-       "model_id": "af76523166d8463c8dd0d2f9156cc801",
+       "model_id": "36f742715157494aab71cafe63e7cdb1",
        "version_major": 2,
        "version_minor": 0
       },
@@ -16882,7 +16660,6 @@
     "# [simulated_data]\n",
     "#\n",
     "\n",
-    "import myokit\n",
     "import numpy as np\n",
     "import pandas as pd\n",
     "import pints\n",
@@ -16902,92 +16679,58 @@
     "path = pkpd.ModelLibrary().get_path('Tumour growth without treatment - dimensionless')\n",
     "model = pkpd.PharmacodynamicModel(path, is_log_transformed=True)\n",
     "\n",
-    "# Define container for the structural model estimates\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
-    "n_mice = len(simulated_data['#ID'].unique())\n",
-    "n_parameters = 3\n",
-    "transf_params_recovered = np.empty(shape=(n_mice, n_runs, n_parameters))\n",
-    "\n",
-    "# Define container for the objective function score for the optimised parameters\n",
-    "scores_recovered = np.empty(shape=(n_mice, n_runs))\n",
-    "\n",
-    "# Define random starting points over many orders of magnitude\n",
-    "# Shape = (n_runs, n_parameters)\n",
+    "# Define initial parameters\n",
+    "n_mice = len(data['#ID'].unique())\n",
+    "n_parameters = model.n_parameters()\n",
     "initial_parameters = np.random.uniform(low=1E-3, high=1E3, size=(n_runs, n_parameters))\n",
+    "log_init_params = np.log(initial_parameters)\n",
     "\n",
-    "# Find mouse parameters for LXF A677 population\n",
-    "mouse_ids = simulated_data['#ID'].unique()\n",
+    "# Create boundaries to biologically relevant values\n",
+    "boundaries = pints.RectangularBoundaries(\n",
+    "    lower=np.log([1E-3] * n_parameters), upper=np.log([1E3] * n_parameters))\n",
+    "\n",
+    "# Find parameters for each mouse\n",
+    "parameters_recovered = []\n",
+    "scores_recovered = []\n",
+    "mouse_ids = data['#ID'].unique()\n",
     "for index, mouse_id in enumerate(tqdm(mouse_ids)):\n",
-    "    # Create mask for mouse with specfied ID\n",
+    "    # Get data\n",
     "    mouse_mask = simulated_data['#ID'] == mouse_id\n",
-    "\n",
-    "    # Get relevant time points\n",
     "    times = simulated_data[mouse_mask]['TIME in day'].to_numpy() / characteristic_time\n",
-    "\n",
-    "    # Get measured tumour volumes\n",
-    "    observed_volumes = simulated_data[mouse_mask]['SIMULATED TUMOUR VOLUME in cm^3'].to_numpy() / characteristic_volume\n",
+    "    observed_volumes = \\\n",
+    "        simulated_data[mouse_mask]['SIMULATED TUMOUR VOLUME in cm^3'].to_numpy() * characteristic_volume\n",
     "\n",
     "    # Create inverse problem\n",
     "    problem = pints.SingleOutputProblem(model, times, observed_volumes)\n",
-    "\n",
-    "    # Create sum of squares error objective function\n",
     "    error = pints.SumOfSquaresError(problem)\n",
     "\n",
-    "    # Create boundaries to biologically relevant values\n",
-    "    boundary = pints.RectangularBoundaries(lower=np.log([1E-3]*3), upper=np.log([1E3]*3))\n",
-    "\n",
     "    # Run optimisation multiple times\n",
-    "    for run_id, initial_params in enumerate(initial_parameters):\n",
-    "        # Transform parameters to log-scale\n",
-    "        log_initial_params = np.log(initial_params)\n",
-    "\n",
-    "        # Create optimisation controller with a CMA-ES optimiser\n",
-    "        optimiser = pints.OptimisationController(\n",
-    "            function=error,\n",
-    "            x0=log_initial_params,\n",
-    "            boundaries=boundary,\n",
-    "            method=pints.CMAES)\n",
-    "\n",
-    "        # Disable logging mode\n",
-    "        optimiser.set_log_to_screen(False)\n",
-    "\n",
-    "        # Parallelise optimisation\n",
-    "        optimiser.set_parallel(True)\n",
-    "\n",
-    "        # Find optimal parameters\n",
-    "        try:\n",
-    "            estimates, score = optimiser.run()\n",
-    "        except:\n",
-    "            # If inference breaks fill estimates with nan\n",
-    "            estimates = np.array([np.nan, np.nan, np.nan])\n",
-    "            score = np.nan\n",
-    "\n",
-    "        # Save estimates and score (back transformed to linear scale)\n",
-    "        transf_params_recovered[index, run_id, :] = np.exp(estimates)\n",
-    "        scores_recovered[index, run_id] = score\n",
+    "    p, s = pkpd.optimise(error, pints.CMAES, log_init_params, n_runs, boundaries)\n",
+    "    parameters_recovered += [p]\n",
+    "    scores_recovered += [s]\n",
     "\n",
     "# Transform log-dimensionless parameters back to biological parameters.\n",
     "# Initialise container for backtransformed paramters\n",
-    "# Shape (n_mice, n_runs, n_parameters)\n",
-    "parameters_recovered = np.empty(shape=transf_params_recovered.shape)\n",
+    "parameters_recovered = np.asarray(parameters_recovered)\n",
+    "p = parameters_recovered.copy()\n",
     "\n",
     "# Transform initial volumes\n",
-    "parameters_recovered[:, :, 0] = transf_params_recovered[:, :, 0] * characteristic_volume\n",
+    "parameters_recovered[:, :, 0] = np.exp(p[:, :, 0]) * characteristic_volume\n",
     "\n",
     "# Transform exponential growth rate\n",
-    "# lambda_0 = a_1 / a_0 /t^c\n",
+    "# lambda_0 = a_1 / 2a_0 /t^c\n",
     "parameters_recovered[:, :, 1] = \\\n",
-    "    transf_params_recovered[:, :, 2] / 2 / transf_params_recovered[:, :, 1] / characteristic_time\n",
+    "    np.exp(p[:, :, 2]) / 2 / np.exp(p[:, :, 1]) / characteristic_time\n",
     "\n",
     "# Transform linear growth rate\n",
     "# lambda_1 = a_1 / a_0 /t^c\n",
     "parameters_recovered[:, :, 2] = \\\n",
-    "    transf_params_recovered[:, :, 2] * characteristic_volume / characteristic_time\n"
+    "    np.exp(p[:, :, 2]) * characteristic_volume / characteristic_time"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 16,
+   "execution_count": 23,
    "metadata": {},
    "outputs": [
     {
@@ -17017,16 +16760,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13952238037445452,
-          0.13952758841463156,
-          0.13952757267940874,
-          0.13952758031592874,
-          0.13952758018705966,
-          0.1395275801195493,
-          0.1395275799555333,
-          0.13952757816340494,
-          0.13952758203878637,
-          0.13956100037753522
+          0.13941949429153408,
+          0.1394194942935415,
+          0.13941949429593628,
+          0.13941949429385594,
+          0.13937441406800297,
+          0.1394194942900723,
+          0.13937449778520153,
+          0.1394194942898707,
+          0.13941949429638978,
+          0.13937439364746573
          ]
         },
         {
@@ -17049,16 +16792,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.2750465873943766,
-          0.27528389485728505,
-          0.2752839404152386,
-          0.2752839289722425,
-          0.27528392222054143,
-          0.27528391096923144,
-          0.2752839134619713,
-          0.2752839368708425,
-          0.2752839118200977,
-          0.27490432434394924
+          0.2751827260792774,
+          0.2751827260742824,
+          0.2751827260474015,
+          0.27518272605047955,
+          0.2753060058855389,
+          0.27518272606089905,
+          0.27530585971111843,
+          0.2751827260820209,
+          0.2751827260423378,
+          0.2753060476246334
          ]
         },
         {
@@ -17081,16 +16824,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13098483892098628,
-          0.13088439447760997,
-          0.13088438854458498,
-          0.13088438865446167,
-          0.13088439068663565,
-          0.13088439209773067,
-          0.13088439172411012,
-          0.1308843884626018,
-          0.13088439140588776,
-          0.13098326340440405
+          0.1310014416626393,
+          0.13100144166311972,
+          0.13100144166596756,
+          0.13100144166612052,
+          0.13091138604732072,
+          0.13100144166520972,
+          0.13091139365984356,
+          0.13100144166252703,
+          0.1310014416669938,
+          0.13091138692113208
          ]
         },
         {
@@ -17113,16 +16856,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          2.0486230266915167e-7,
-          1.1592235775976535e-8,
-          1.1592235151122759e-8,
-          1.1592235584007242e-8,
-          1.1592236002316385e-8,
-          1.1592235749879935e-8,
-          1.1592235690922885e-8,
-          1.1592235938733825e-8,
-          1.1592235745577248e-8,
-          7.854735855666878e-24
+          1.9535279492594834e-23,
+          2.3166389170965613e-23,
+          3.282459558371508e-23,
+          3.4059562751946184e-24,
+          1.9053062475082862e-08,
+          4.039578946554816e-23,
+          1.9053067059052494e-08,
+          3.5014584057372714e-23,
+          1.7218179786667206e-23,
+          1.90531137033178e-08
          ]
         },
         {
@@ -17145,16 +16888,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07455441080382476,
-          0.07455441080422921,
-          0.07455441080442336,
-          0.07455441080398487,
-          0.07455441080415164,
-          0.07471438383609569,
-          0.07455441080455912,
-          0.07455441080414442,
-          0.07455441080535598,
-          0.07455441080478163
+          0.07465792492920492,
+          0.0746579249096991,
+          0.07465792492193521,
+          0.07465792492666053,
+          0.07466209115400987,
+          0.07465792489990465,
+          0.07465792491642866,
+          0.07465792489966043,
+          0.0746579249169771,
+          0.0746579248965519
          ]
         },
         {
@@ -17177,16 +16920,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.16791201833352884,
-          0.16791201833152608,
-          0.16791201833232375,
-          0.1679120183339814,
-          0.1679120183321798,
-          0.16553665130295306,
-          0.16791201833145433,
-          0.16791201833353522,
-          0.1679120183291452,
-          0.16791201833212516
+          0.16794715896188755,
+          0.16794715924973969,
+          0.1679471592041641,
+          0.16794715905837268,
+          0.16787357364792022,
+          0.16794715941068997,
+          0.16794715921278958,
+          0.16794715925778933,
+          0.16794715920743197,
+          0.16794715928209236
          ]
         },
         {
@@ -17209,16 +16952,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.020313900743351005,
-          0.02031390074338527,
-          0.020313900743333425,
-          0.020313900743283313,
-          0.020313900743365015,
-          0.020380836218904134,
-          0.020313900743347865,
-          0.020313900743310274,
-          0.020313900743330015,
-          0.020313900743308824
+          0.020312904789642223,
+          0.020312904781031926,
+          0.020312904781106617,
+          0.02031290478622726,
+          0.020315353016124058,
+          0.02031290477595091,
+          0.02031290478256582,
+          0.02031290478257819,
+          0.02031290478147156,
+          0.02031290478140458
          ]
         },
         {
@@ -17241,16 +16984,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          4.195082114743824e-21,
-          4.194006591058806e-21,
-          4.1961279349692365e-21,
-          4.195734692208734e-21,
-          4.193418746750948e-21,
-          7.232362718082441e-8,
-          4.19611602711445e-21,
-          4.193209752233191e-21,
-          4.201354889527004e-21,
-          4.1968758156401224e-21
+          1.4406177476094372e-21,
+          4.156203775553495e-21,
+          5.150560052222719e-21,
+          5.0633086140723125e-21,
+          7.105876085423447e-11,
+          7.440500345425091e-21,
+          4.228156159362001e-21,
+          4.079206158682102e-21,
+          4.570117912107593e-21,
+          4.37399728203342e-21
          ]
         },
         {
@@ -17273,16 +17016,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.2208905922850747,
-          0.2208913929437088,
-          0.22089086294121354,
-          0.2208927019682394,
-          0.220890155699102,
-          0.2208911282149942,
-          0.22089110719701446,
-          0.2208914010417227,
-          0.06033758363587237,
-          0.22089239011837547
+          0.22089100225568367,
+          0.2208906069907651,
+          0.22089355050515128,
+          0.22088864155801122,
+          0.2208908733411936,
+          0.2208911410047391,
+          0.22089105647610602,
+          0.22089254458091453,
+          0.2208896962036516,
+          0.22089068938355505
          ]
         },
         {
@@ -17305,16 +17048,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05559706636028768,
-          0.055596745489639235,
-          0.05559704489637324,
-          0.05559638033200172,
-          0.05559727619106938,
-          0.05559692391416542,
-          0.055596957803573294,
-          0.055596797000679925,
-          0.45248299231404765,
-          0.05559647399558313
+          0.05559693834980881,
+          0.0555970443021783,
+          0.05559616058581889,
+          0.05559776840225496,
+          0.05559700019166884,
+          0.055596889841239484,
+          0.055596911609132806,
+          0.05559651036816146,
+          0.055597377114357166,
+          0.05559701076903655
          ]
         },
         {
@@ -17337,16 +17080,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          104.21328885046559,
-          104.69755606068662,
-          104.17698592923412,
-          105.17652781999737,
-          103.8791129330722,
-          104.39359988041463,
-          104.33342947504117,
-          104.59417673656365,
-          0.10386738029528089,
-          105.04666367435385
+          104.36870227112536,
+          104.28727633867017,
+          105.44067028836051,
+          103.15736825521745,
+          104.26989320637891,
+          104.43577452111668,
+          104.43250451236113,
+          104.93544551004672,
+          103.75149750604143,
+          104.31392484136896
          ]
         },
         {
@@ -17369,16 +17112,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          1.4096679323868144e-9,
-          1.2101490000082694e-9,
-          1.4248724596892424e-9,
-          1.0274077939295006e-9,
-          1.560169568159229e-9,
-          1.3337038214742488e-9,
-          1.3609621371462236e-9,
-          1.2504420645180298e-9,
-          0.28794677994402756,
-          1.0748764655864024e-9
+          1.3425593586271329e-09,
+          1.3841191024302172e-09,
+          9.352893924068188e-10,
+          1.90646559300323e-09,
+          1.3842871668696892e-09,
+          1.3147234801983351e-09,
+          1.3167790977036422e-09,
+          1.1188781457291046e-09,
+          1.6157731721515288e-09,
+          1.367534632292444e-09
          ]
         },
         {
@@ -17401,16 +17144,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14901045435335528,
-          0.14899746350923354,
-          0.14901045435225374,
-          0.1490066353702117,
-          0.14901045407540278,
-          0.14901045630977316,
-          0.14901045412365885,
-          0.1490104544128475,
-          0.14901045591242093,
-          0.14899576679435553
+          0.14845678435467352,
+          0.14845678435467347,
+          0.1484567843546777,
+          0.14845678435467274,
+          0.14845678435467294,
+          0.14845678435467136,
+          0.14845678435467163,
+          0.148456784354671,
+          0.1484567843546529,
+          0.14845678435467266
          ]
         },
         {
@@ -17433,16 +17176,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0542476897981738,
-          0.05426001182189589,
-          0.05424768993622171,
-          0.054256228667620844,
-          0.054247689974706505,
-          0.05424768896118578,
-          0.054247690313557154,
-          0.054247689860069136,
-          0.054247689551500625,
-          0.05426036691945059
+          0.054746131956498786,
+          0.05474613195649798,
+          0.054746131956495456,
+          0.05474613195649765,
+          0.05474613195649895,
+          0.05474613195649944,
+          0.05474613195649822,
+          0.05474613195649812,
+          0.05474613195650275,
+          0.05474613195649506
          ]
         },
         {
@@ -17465,16 +17208,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12886479526985578,
-          0.128804691604079,
-          0.1288647946370517,
-          0.12881171949352424,
-          0.12886479489791205,
-          0.12886479783734028,
-          0.12886479336105316,
-          0.12886479498664696,
-          0.12886479498278633,
-          0.12880424952566225
+          0.12685798189307998,
+          0.12685798189308714,
+          0.1268579818930966,
+          0.12685798189309228,
+          0.12685798189308534,
+          0.12685798189308264,
+          0.1268579818930896,
+          0.12685798189309108,
+          0.12685798189309458,
+          0.12685798189310427
          ]
         },
         {
@@ -17497,16 +17240,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          2.0541032095052e-9,
-          1.8111212021968598e-10,
-          2.0541031560403797e-9,
-          3.2937191965046066e-10,
-          2.054103154558136e-9,
-          2.0541032012022375e-9,
-          2.0541031883026445e-9,
-          2.054103217446828e-9,
-          2.0541032032993066e-9,
-          1.8015124669415312e-10
+          6.822861050744442e-28,
+          7.37500205464093e-29,
+          1.686375074184574e-28,
+          1.1128793590647204e-29,
+          3.07597975137863e-28,
+          1.0446629204345245e-28,
+          3.2834794435869107e-29,
+          1.690966491171993e-29,
+          6.846713307919689e-27,
+          8.602173800325366e-28
          ]
         },
         {
@@ -17529,16 +17272,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08416667209615447,
-          0.08416595172860288,
-          0.0841681249919099,
-          0.08416849802135681,
-          0.08416658484502194,
-          0.08416733444413829,
-          0.08416660733087476,
-          0.08416688728925666,
-          0.08416566979673375,
-          0.08416667774388847
+          0.08416703651937057,
+          0.0841681674954038,
+          0.08416615826251642,
+          0.08416684503483268,
+          0.08416579369943396,
+          0.08416521111045502,
+          0.08417133596394909,
+          0.08416750820973966,
+          0.08416506996025219,
+          0.08416725144032874
          ]
         },
         {
@@ -17561,16 +17304,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.05418706873536728,
-          0.05418732550627742,
-          0.05418648228565381,
-          0.05418627157217991,
-          0.05418710833690155,
-          0.05418673835288372,
-          0.05418714041464892,
-          0.054186980538867086,
-          0.05418746730691929,
-          0.0541870374052075
+          0.05418688646839237,
+          0.054186410082625355,
+          0.05418731557066853,
+          0.05418703833493856,
+          0.054187396613881604,
+          0.05418768827907849,
+          0.054185034258764295,
+          0.054186719062720885,
+          0.05418773134967723,
+          0.054186754675456555
          ]
         },
         {
@@ -17593,16 +17336,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          100.98148912160828,
-          100.63962181398746,
-          101.81298897328486,
-          102.20759707497756,
-          100.8890155665599,
-          101.56924314916056,
-          100.78925616710785,
-          101.07748644721256,
-          100.39090252855112,
-          101.04871415407041
+          101.28732939207514,
+          102.02076743261355,
+          100.54185468418677,
+          100.94468134496239,
+          100.51172593726247,
+          100.04506168425547,
+          104.24357379073825,
+          101.49347061960093,
+          99.99338364402865,
+          101.54315777047889
          ]
         },
         {
@@ -17625,16 +17368,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          1.817210775837478e-9,
-          2.0007561375887497e-9,
-          1.4091989381935081e-9,
-          1.2316784882957028e-9,
-          1.8630134739676265e-9,
-          1.5242350511082555e-9,
-          1.920500076409589e-9,
-          1.7638856403863322e-9,
-          2.1408954466056496e-9,
-          1.778662336622915e-9
+          1.6574231840976273e-09,
+          1.3135179290289341e-09,
+          2.0555084798113287e-09,
+          1.8372998284455756e-09,
+          2.0727935666924354e-09,
+          2.3489728304768556e-09,
+          5.31283750015558e-10,
+          1.5569591081210712e-09,
+          2.3791214447090633e-09,
+          1.533062285670624e-09
          ]
         },
         {
@@ -17657,16 +17400,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.13324572357191233,
-          0.13324572012213717,
-          0.13324572434138549,
-          0.13327412171312955,
-          0.13324572553596145,
-          0.13324572377324492,
-          0.13324572400091828,
-          0.1332457228269579,
-          0.13324572342207455,
-          0.13327412171311895
+          0.13327413294382767,
+          0.13324573708065623,
+          0.13327413294334928,
+          0.1332741329438668,
+          0.1332741329441626,
+          0.133274132943881,
+          0.13324573491181993,
+          0.13324573476502327,
+          0.1332457365344882,
+          0.13324573685036997
          ]
         },
         {
@@ -17689,16 +17432,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.19759258119855846,
-          0.19759258628357898,
-          0.19759257564618063,
-          0.19735956966771176,
-          0.19759257232731184,
-          0.19759258034235735,
-          0.19759258095715557,
-          0.1975925791331269,
-          0.1975925769984686,
-          0.1973595696677273
+          0.19735956642415955,
+          0.19759257250535817,
+          0.197359566419445,
+          0.19735956642410335,
+          0.19735956642108574,
+          0.19735956642405242,
+          0.19759257230849167,
+          0.1975925769491612,
+          0.197592571361788,
+          0.19759257020493143
          ]
         },
         {
@@ -17721,16 +17464,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.10854044918136324,
-          0.10854044890819099,
-          0.10854045055093599,
-          0.1085369034644263,
-          0.10854045074255882,
-          0.10854044940647614,
-          0.10854044922060106,
-          0.10854044982840598,
-          0.10854045009362136,
-          0.10853690346442263
+          0.10853691481539168,
+          0.10854046125133568,
+          0.1085369148174958,
+          0.10853691481539592,
+          0.10853691481711251,
+          0.10853691481540599,
+          0.10854046122595577,
+          0.1085404604672549,
+          0.10854046140691083,
+          0.10854046149978953
          ]
         },
         {
@@ -17753,16 +17496,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          9.76339827083392e-9,
-          9.763398354804133e-9,
-          9.763398344282205e-9,
-          1.2425021480417589e-28,
-          9.763398404677993e-9,
-          9.763398352786179e-9,
-          9.763398362762709e-9,
-          9.763398350761785e-9,
-          9.76339841570709e-9,
-          1.2377512640549445e-27
+          3.1596334159194063e-23,
+          9.763488361922037e-09,
+          2.0682340633024437e-23,
+          3.1584421244796974e-23,
+          1.8027818974590344e-23,
+          3.1587200377114165e-23,
+          9.763488451011561e-09,
+          9.763488392129775e-09,
+          9.76348836165004e-09,
+          9.763488393849765e-09
          ]
         },
         {
@@ -17785,16 +17528,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12332984325963313,
-          0.12332984325961999,
-          0.12332984325963203,
-          0.12332984325963313,
-          0.12332984325962043,
-          0.12332984325947928,
-          0.12332984325910312,
-          0.12332984325963138,
-          0.12332984325962656,
-          0.12332984325967783
+          0.12380947161166297,
+          0.1238094716116964,
+          0.12380947161119409,
+          0.12380947161166667,
+          0.12380947161161976,
+          0.1238094716116252,
+          0.12380947161161306,
+          0.12380947161167397,
+          0.12380947161162471,
+          0.12380947161157853
          ]
         },
         {
@@ -17817,16 +17560,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.04352115325871012,
-          0.043521153258716846,
-          0.04352115325871348,
-          0.04352115325871065,
-          0.04352115325871909,
-          0.043521153258714675,
-          0.0435211532591607,
-          0.04352115325871199,
-          0.0435211532587158,
-          0.04352115325867208
+          0.04303162124932943,
+          0.04303162124933502,
+          0.04303162124927005,
+          0.04303162124930733,
+          0.04303162124935504,
+          0.04303162124932943,
+          0.04303162124932172,
+          0.04303162124929208,
+          0.04303162124932515,
+          0.04303162124933184
          ]
         },
         {
@@ -17849,16 +17592,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07139562021248035,
-          0.07139562021246448,
-          0.0713956202124669,
-          0.07139562021247575,
-          0.0713956202124603,
-          0.07139562021438879,
-          0.07139562021289224,
-          0.07139562021247255,
-          0.07139562021245846,
-          0.07139562021260247
+          0.07299522226317601,
+          0.07299522226313218,
+          0.07299522226722187,
+          0.07299522226329397,
+          0.07299522226315475,
+          0.07299522226321724,
+          0.07299522226328753,
+          0.07299522226334233,
+          0.07299522226327118,
+          0.07299522226328976
          ]
         },
         {
@@ -17881,16 +17624,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          2.4877237091649926e-30,
-          7.729999091640107e-28,
-          1.7683811712165824e-28,
-          1.0792333629362754e-29,
-          1.4174412982382513e-27,
-          1.2462334986420532e-24,
-          1.487320521611929e-24,
-          2.5735816660857755e-29,
-          5.593919375441114e-28,
-          1.2477707990348224e-26
+          8.417680184089735e-24,
+          8.459431008803015e-24,
+          4.1619667168063266e-24,
+          8.446925075924145e-24,
+          8.516141293484829e-24,
+          8.448824868688071e-24,
+          8.464637356925342e-24,
+          8.447793195779926e-24,
+          8.461777905625751e-24,
+          8.508019824094903e-24
          ]
         },
         {
@@ -17913,16 +17656,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08704782573719047,
-          0.08704782573727421,
-          0.08704782573727336,
-          0.08704782573723721,
-          0.08704782573727336,
-          0.08704782573724336,
-          0.0870478257372732,
-          0.08704782573739257,
-          0.08704782573727633,
-          0.08704782573727177
+          0.08704782268067632,
+          0.08704782268062707,
+          0.08704782268072085,
+          0.08704782268043953,
+          0.08704782268061849,
+          0.08704782268065393,
+          0.08704782268069812,
+          0.0870478226805605,
+          0.08704782268064709,
+          0.0870478226806561
          ]
         },
         {
@@ -17945,16 +17688,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.03617215562978255,
-          0.03617215562972088,
-          0.03617215562971934,
-          0.036172155629734075,
-          0.03617215562972253,
-          0.03617215562974665,
-          0.036172155629719954,
-          0.036172155629608724,
-          0.03617215562971751,
-          0.03617215562971886
+          0.036172156305019555,
+          0.036172156305028805,
+          0.0361721563049974,
+          0.036172156305190925,
+          0.036172156305055346,
+          0.03617215630503042,
+          0.03617215630500931,
+          0.03617215630512633,
+          0.03617215630503382,
+          0.0361721563050359
          ]
         },
         {
@@ -17977,16 +17720,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.19325840668914354,
-          0.19325840669148706,
-          0.1932584066915413,
-          0.19325840669134248,
-          0.19325840669135044,
-          0.19325840669048874,
-          0.19325840669152689,
-          0.19325840669472366,
-          0.19325840669161787,
-          0.1932584066915952
+          0.1932584036886913,
+          0.19325840368889385,
+          0.19325840368968167,
+          0.19325840368222383,
+          0.19325840368922512,
+          0.19325840368838082,
+          0.19325840368916697,
+          0.19325840368415725,
+          0.19325840368818975,
+          0.19325840368960687
          ]
         },
         {
@@ -18009,16 +17752,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          2.7261430626280234e-25,
-          2.295176114672848e-25,
-          2.269488030259732e-25,
-          2.477348293146271e-25,
-          2.281058584031373e-25,
-          2.434683987534417e-25,
-          2.277434026246495e-25,
-          1.1989081864160993e-25,
-          2.2748927828701054e-25,
-          2.2710417029829584e-25
+          1.641859899821985e-27,
+          2.5258034656556092e-26,
+          9.189852159852185e-26,
+          2.697447759940333e-25,
+          2.2675931097133793e-25,
+          2.1762584666988e-28,
+          3.064823551804874e-26,
+          1.1060701682647212e-25,
+          5.867307442162815e-27,
+          2.650354246864696e-25
          ]
         }
        ],
@@ -19199,20 +18942,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"a87d4a0b-5347-4d10-9b99-cbe966d26fa1\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"2b628f36-cb53-4986-a2d5-fcb891a133e8\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"a87d4a0b-5347-4d10-9b99-cbe966d26fa1\")) {\n",
+       "                if (document.getElementById(\"2b628f36-cb53-4986-a2d5-fcb891a133e8\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        'a87d4a0b-5347-4d10-9b99-cbe966d26fa1',\n",
-       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13952238037445452, 0.13952758841463156, 0.13952757267940874, 0.13952758031592874, 0.13952758018705966, 0.1395275801195493, 0.1395275799555333, 0.13952757816340494, 0.13952758203878637, 0.13956100037753522]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.2750465873943766, 0.27528389485728505, 0.2752839404152386, 0.2752839289722425, 0.27528392222054143, 0.27528391096923144, 0.2752839134619713, 0.2752839368708425, 0.2752839118200977, 0.27490432434394924]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13098483892098628, 0.13088439447760997, 0.13088438854458498, 0.13088438865446167, 0.13088439068663565, 0.13088439209773067, 0.13088439172411012, 0.1308843884626018, 0.13088439140588776, 0.13098326340440405]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [2.0486230266915167e-07, 1.1592235775976535e-08, 1.1592235151122759e-08, 1.1592235584007242e-08, 1.1592236002316385e-08, 1.1592235749879935e-08, 1.1592235690922885e-08, 1.1592235938733825e-08, 1.1592235745577248e-08, 7.854735855666878e-24]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07455441080382476, 0.07455441080422921, 0.07455441080442336, 0.07455441080398487, 0.07455441080415164, 0.07471438383609569, 0.07455441080455912, 0.07455441080414442, 0.07455441080535598, 0.07455441080478163]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.16791201833352884, 0.16791201833152608, 0.16791201833232375, 0.1679120183339814, 0.1679120183321798, 0.16553665130295306, 0.16791201833145433, 0.16791201833353522, 0.1679120183291452, 0.16791201833212516]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.020313900743351005, 0.02031390074338527, 0.020313900743333425, 0.020313900743283313, 0.020313900743365015, 0.020380836218904134, 0.020313900743347865, 0.020313900743310274, 0.020313900743330015, 0.020313900743308824]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [4.195082114743824e-21, 4.194006591058806e-21, 4.1961279349692365e-21, 4.195734692208734e-21, 4.193418746750948e-21, 7.232362718082441e-08, 4.19611602711445e-21, 4.193209752233191e-21, 4.201354889527004e-21, 4.1968758156401224e-21]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2208905922850747, 0.2208913929437088, 0.22089086294121354, 0.2208927019682394, 0.220890155699102, 0.2208911282149942, 0.22089110719701446, 0.2208914010417227, 0.06033758363587237, 0.22089239011837547]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05559706636028768, 0.055596745489639235, 0.05559704489637324, 0.05559638033200172, 0.05559727619106938, 0.05559692391416542, 0.055596957803573294, 0.055596797000679925, 0.45248299231404765, 0.05559647399558313]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [104.21328885046559, 104.69755606068662, 104.17698592923412, 105.17652781999737, 103.8791129330722, 104.39359988041463, 104.33342947504117, 104.59417673656365, 0.10386738029528089, 105.04666367435385]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.4096679323868144e-09, 1.2101490000082694e-09, 1.4248724596892424e-09, 1.0274077939295006e-09, 1.560169568159229e-09, 1.3337038214742488e-09, 1.3609621371462236e-09, 1.2504420645180298e-09, 0.28794677994402756, 1.0748764655864024e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14901045435335528, 0.14899746350923354, 0.14901045435225374, 0.1490066353702117, 0.14901045407540278, 0.14901045630977316, 0.14901045412365885, 0.1490104544128475, 0.14901045591242093, 0.14899576679435553]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0542476897981738, 0.05426001182189589, 0.05424768993622171, 0.054256228667620844, 0.054247689974706505, 0.05424768896118578, 0.054247690313557154, 0.054247689860069136, 0.054247689551500625, 0.05426036691945059]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12886479526985578, 0.128804691604079, 0.1288647946370517, 0.12881171949352424, 0.12886479489791205, 0.12886479783734028, 0.12886479336105316, 0.12886479498664696, 0.12886479498278633, 0.12880424952566225]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.0541032095052e-09, 1.8111212021968598e-10, 2.0541031560403797e-09, 3.2937191965046066e-10, 2.054103154558136e-09, 2.0541032012022375e-09, 2.0541031883026445e-09, 2.054103217446828e-09, 2.0541032032993066e-09, 1.8015124669415312e-10]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08416667209615447, 0.08416595172860288, 0.0841681249919099, 0.08416849802135681, 0.08416658484502194, 0.08416733444413829, 0.08416660733087476, 0.08416688728925666, 0.08416566979673375, 0.08416667774388847]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05418706873536728, 0.05418732550627742, 0.05418648228565381, 0.05418627157217991, 0.05418710833690155, 0.05418673835288372, 0.05418714041464892, 0.054186980538867086, 0.05418746730691929, 0.0541870374052075]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [100.98148912160828, 100.63962181398746, 101.81298897328486, 102.20759707497756, 100.8890155665599, 101.56924314916056, 100.78925616710785, 101.07748644721256, 100.39090252855112, 101.04871415407041]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.817210775837478e-09, 2.0007561375887497e-09, 1.4091989381935081e-09, 1.2316784882957028e-09, 1.8630134739676265e-09, 1.5242350511082555e-09, 1.920500076409589e-09, 1.7638856403863322e-09, 2.1408954466056496e-09, 1.778662336622915e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13324572357191233, 0.13324572012213717, 0.13324572434138549, 0.13327412171312955, 0.13324572553596145, 0.13324572377324492, 0.13324572400091828, 0.1332457228269579, 0.13324572342207455, 0.13327412171311895]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19759258119855846, 0.19759258628357898, 0.19759257564618063, 0.19735956966771176, 0.19759257232731184, 0.19759258034235735, 0.19759258095715557, 0.1975925791331269, 0.1975925769984686, 0.1973595696677273]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10854044918136324, 0.10854044890819099, 0.10854045055093599, 0.1085369034644263, 0.10854045074255882, 0.10854044940647614, 0.10854044922060106, 0.10854044982840598, 0.10854045009362136, 0.10853690346442263]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [9.76339827083392e-09, 9.763398354804133e-09, 9.763398344282205e-09, 1.2425021480417589e-28, 9.763398404677993e-09, 9.763398352786179e-09, 9.763398362762709e-09, 9.763398350761785e-09, 9.76339841570709e-09, 1.2377512640549445e-27]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12332984325963313, 0.12332984325961999, 0.12332984325963203, 0.12332984325963313, 0.12332984325962043, 0.12332984325947928, 0.12332984325910312, 0.12332984325963138, 0.12332984325962656, 0.12332984325967783]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04352115325871012, 0.043521153258716846, 0.04352115325871348, 0.04352115325871065, 0.04352115325871909, 0.043521153258714675, 0.0435211532591607, 0.04352115325871199, 0.0435211532587158, 0.04352115325867208]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07139562021248035, 0.07139562021246448, 0.0713956202124669, 0.07139562021247575, 0.0713956202124603, 0.07139562021438879, 0.07139562021289224, 0.07139562021247255, 0.07139562021245846, 0.07139562021260247]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.4877237091649926e-30, 7.729999091640107e-28, 1.7683811712165824e-28, 1.0792333629362754e-29, 1.4174412982382513e-27, 1.2462334986420532e-24, 1.487320521611929e-24, 2.5735816660857755e-29, 5.593919375441114e-28, 1.2477707990348224e-26]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704782573719047, 0.08704782573727421, 0.08704782573727336, 0.08704782573723721, 0.08704782573727336, 0.08704782573724336, 0.0870478257372732, 0.08704782573739257, 0.08704782573727633, 0.08704782573727177]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.03617215562978255, 0.03617215562972088, 0.03617215562971934, 0.036172155629734075, 0.03617215562972253, 0.03617215562974665, 0.036172155629719954, 0.036172155629608724, 0.03617215562971751, 0.03617215562971886]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19325840668914354, 0.19325840669148706, 0.1932584066915413, 0.19325840669134248, 0.19325840669135044, 0.19325840669048874, 0.19325840669152689, 0.19325840669472366, 0.19325840669161787, 0.1932584066915952]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.7261430626280234e-25, 2.295176114672848e-25, 2.269488030259732e-25, 2.477348293146271e-25, 2.281058584031373e-25, 2.434683987534417e-25, 2.277434026246495e-25, 1.1989081864160993e-25, 2.2748927828701054e-25, 2.2710417029829584e-25]}],\n",
+       "                        '2b628f36-cb53-4986-a2d5-fcb891a133e8',\n",
+       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13941949429153408, 0.1394194942935415, 0.13941949429593628, 0.13941949429385594, 0.13937441406800297, 0.1394194942900723, 0.13937449778520153, 0.1394194942898707, 0.13941949429638978, 0.13937439364746573]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.2751827260792774, 0.2751827260742824, 0.2751827260474015, 0.27518272605047955, 0.2753060058855389, 0.27518272606089905, 0.27530585971111843, 0.2751827260820209, 0.2751827260423378, 0.2753060476246334]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.1310014416626393, 0.13100144166311972, 0.13100144166596756, 0.13100144166612052, 0.13091138604732072, 0.13100144166520972, 0.13091139365984356, 0.13100144166252703, 0.1310014416669938, 0.13091138692113208]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [1.9535279492594834e-23, 2.3166389170965613e-23, 3.282459558371508e-23, 3.4059562751946184e-24, 1.9053062475082862e-08, 4.039578946554816e-23, 1.9053067059052494e-08, 3.5014584057372714e-23, 1.7218179786667206e-23, 1.90531137033178e-08]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07465792492920492, 0.0746579249096991, 0.07465792492193521, 0.07465792492666053, 0.07466209115400987, 0.07465792489990465, 0.07465792491642866, 0.07465792489966043, 0.0746579249169771, 0.0746579248965519]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.16794715896188755, 0.16794715924973969, 0.1679471592041641, 0.16794715905837268, 0.16787357364792022, 0.16794715941068997, 0.16794715921278958, 0.16794715925778933, 0.16794715920743197, 0.16794715928209236]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.020312904789642223, 0.020312904781031926, 0.020312904781106617, 0.02031290478622726, 0.020315353016124058, 0.02031290477595091, 0.02031290478256582, 0.02031290478257819, 0.02031290478147156, 0.02031290478140458]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.4406177476094372e-21, 4.156203775553495e-21, 5.150560052222719e-21, 5.0633086140723125e-21, 7.105876085423447e-11, 7.440500345425091e-21, 4.228156159362001e-21, 4.079206158682102e-21, 4.570117912107593e-21, 4.37399728203342e-21]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.22089100225568367, 0.2208906069907651, 0.22089355050515128, 0.22088864155801122, 0.2208908733411936, 0.2208911410047391, 0.22089105647610602, 0.22089254458091453, 0.2208896962036516, 0.22089068938355505]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05559693834980881, 0.0555970443021783, 0.05559616058581889, 0.05559776840225496, 0.05559700019166884, 0.055596889841239484, 0.055596911609132806, 0.05559651036816146, 0.055597377114357166, 0.05559701076903655]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [104.36870227112536, 104.28727633867017, 105.44067028836051, 103.15736825521745, 104.26989320637891, 104.43577452111668, 104.43250451236113, 104.93544551004672, 103.75149750604143, 104.31392484136896]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.3425593586271329e-09, 1.3841191024302172e-09, 9.352893924068188e-10, 1.90646559300323e-09, 1.3842871668696892e-09, 1.3147234801983351e-09, 1.3167790977036422e-09, 1.1188781457291046e-09, 1.6157731721515288e-09, 1.367534632292444e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14845678435467352, 0.14845678435467347, 0.1484567843546777, 0.14845678435467274, 0.14845678435467294, 0.14845678435467136, 0.14845678435467163, 0.148456784354671, 0.1484567843546529, 0.14845678435467266]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.054746131956498786, 0.05474613195649798, 0.054746131956495456, 0.05474613195649765, 0.05474613195649895, 0.05474613195649944, 0.05474613195649822, 0.05474613195649812, 0.05474613195650275, 0.05474613195649506]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12685798189307998, 0.12685798189308714, 0.1268579818930966, 0.12685798189309228, 0.12685798189308534, 0.12685798189308264, 0.1268579818930896, 0.12685798189309108, 0.12685798189309458, 0.12685798189310427]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [6.822861050744442e-28, 7.37500205464093e-29, 1.686375074184574e-28, 1.1128793590647204e-29, 3.07597975137863e-28, 1.0446629204345245e-28, 3.2834794435869107e-29, 1.690966491171993e-29, 6.846713307919689e-27, 8.602173800325366e-28]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08416703651937057, 0.0841681674954038, 0.08416615826251642, 0.08416684503483268, 0.08416579369943396, 0.08416521111045502, 0.08417133596394909, 0.08416750820973966, 0.08416506996025219, 0.08416725144032874]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.05418688646839237, 0.054186410082625355, 0.05418731557066853, 0.05418703833493856, 0.054187396613881604, 0.05418768827907849, 0.054185034258764295, 0.054186719062720885, 0.05418773134967723, 0.054186754675456555]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [101.28732939207514, 102.02076743261355, 100.54185468418677, 100.94468134496239, 100.51172593726247, 100.04506168425547, 104.24357379073825, 101.49347061960093, 99.99338364402865, 101.54315777047889]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.6574231840976273e-09, 1.3135179290289341e-09, 2.0555084798113287e-09, 1.8372998284455756e-09, 2.0727935666924354e-09, 2.3489728304768556e-09, 5.31283750015558e-10, 1.5569591081210712e-09, 2.3791214447090633e-09, 1.533062285670624e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13327413294382767, 0.13324573708065623, 0.13327413294334928, 0.1332741329438668, 0.1332741329441626, 0.133274132943881, 0.13324573491181993, 0.13324573476502327, 0.1332457365344882, 0.13324573685036997]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.19735956642415955, 0.19759257250535817, 0.197359566419445, 0.19735956642410335, 0.19735956642108574, 0.19735956642405242, 0.19759257230849167, 0.1975925769491612, 0.197592571361788, 0.19759257020493143]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10853691481539168, 0.10854046125133568, 0.1085369148174958, 0.10853691481539592, 0.10853691481711251, 0.10853691481540599, 0.10854046122595577, 0.1085404604672549, 0.10854046140691083, 0.10854046149978953]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [3.1596334159194063e-23, 9.763488361922037e-09, 2.0682340633024437e-23, 3.1584421244796974e-23, 1.8027818974590344e-23, 3.1587200377114165e-23, 9.763488451011561e-09, 9.763488392129775e-09, 9.76348836165004e-09, 9.763488393849765e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12380947161166297, 0.1238094716116964, 0.12380947161119409, 0.12380947161166667, 0.12380947161161976, 0.1238094716116252, 0.12380947161161306, 0.12380947161167397, 0.12380947161162471, 0.12380947161157853]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.04303162124932943, 0.04303162124933502, 0.04303162124927005, 0.04303162124930733, 0.04303162124935504, 0.04303162124932943, 0.04303162124932172, 0.04303162124929208, 0.04303162124932515, 0.04303162124933184]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07299522226317601, 0.07299522226313218, 0.07299522226722187, 0.07299522226329397, 0.07299522226315475, 0.07299522226321724, 0.07299522226328753, 0.07299522226334233, 0.07299522226327118, 0.07299522226328976]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [8.417680184089735e-24, 8.459431008803015e-24, 4.1619667168063266e-24, 8.446925075924145e-24, 8.516141293484829e-24, 8.448824868688071e-24, 8.464637356925342e-24, 8.447793195779926e-24, 8.461777905625751e-24, 8.508019824094903e-24]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704782268067632, 0.08704782268062707, 0.08704782268072085, 0.08704782268043953, 0.08704782268061849, 0.08704782268065393, 0.08704782268069812, 0.0870478226805605, 0.08704782268064709, 0.0870478226806561]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Exponential growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.036172156305019555, 0.036172156305028805, 0.0361721563049974, 0.036172156305190925, 0.036172156305055346, 0.03617215630503042, 0.03617215630500931, 0.03617215630512633, 0.03617215630503382, 0.0361721563050359]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Linear growth rate in cm^3/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1932584036886913, 0.19325840368889385, 0.19325840368968167, 0.19325840368222383, 0.19325840368922512, 0.19325840368838082, 0.19325840368916697, 0.19325840368415725, 0.19325840368818975, 0.19325840368960687]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.641859899821985e-27, 2.5258034656556092e-26, 9.189852159852185e-26, 2.697447759940333e-25, 2.2675931097133793e-25, 2.1762584666988e-28, 3.064823551804874e-26, 1.1060701682647212e-25, 5.867307442162815e-27, 2.650354246864696e-25]}],\n",
        "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"visible\": [true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 40\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 94\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 95\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 136\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 140\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 155\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false]}], \"label\": \"ID: 169\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true]}], \"label\": \"ID: 170\", \"method\": \"restyle\"}], \"direction\": \"right\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"yaxis\": {\"title\": {\"text\": \"Estimates\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('a87d4a0b-5347-4d10-9b99-cbe966d26fa1');\n",
+       "var gd = document.getElementById('2b628f36-cb53-4986-a2d5-fcb891a133e8');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -19293,7 +19036,7 @@
   },
   {
    "cell_type": "code",
-   "execution_count": 18,
+   "execution_count": 24,
    "metadata": {},
    "outputs": [],
    "source": [
@@ -19301,7 +19044,7 @@
     "# Transform dimensionless parameters to new set of biological parameters.\n",
     "# \n",
     "# This cell needs the above inferred dimensionless parameters and the characteristic volume and time scale:\n",
-    "# [transf_params_recovered, characteristic_volume, characteristic_time]\n",
+    "# [parameters_recovered]\n",
     "#\n",
     "\n",
     "import numpy as np\n",
@@ -19309,24 +19052,23 @@
     "\n",
     "# Initialise container for backtransformed parameters\n",
     "# Shape (n_mice, n_runs, n_parameters)\n",
-    "new_parameters = np.empty(shape=transf_params_recovered.shape)\n",
+    "new_parameters = np.empty(shape=parameters_recovered.shape)\n",
     "\n",
     "# Transform initial volumes\n",
-    "new_parameters[:, :, 0] = transf_params_recovered[:, :, 0] * characteristic_volume\n",
+    "new_parameters[:, :, 0] = parameters_recovered[:, :, 0]\n",
     "\n",
     "# Transform critical volume \n",
-    "# V_crit = a_0 * V^c\n",
-    "new_parameters[:, :, 1] = transf_params_recovered[:, :, 1] * characteristic_volume\n",
+    "# V_crit = lambda_1 / 2lambda_0\n",
+    "new_parameters[:, :, 1] = parameters_recovered[:, :, 2] / 2 / parameters_recovered[:, :, 1]\n",
     "\n",
     "# Transform exponential growth rate\n",
-    "# lambda = a_1 / a_0 / t^c\n",
-    "new_parameters[:, :, 2] = \\\n",
-    "    transf_params_recovered[:, :, 2] / transf_params_recovered[:, :, 1] / characteristic_time\n"
+    "# lambda = 2lambda_0\n",
+    "new_parameters[:, :, 2] = 2 * parameters_recovered[:, :, 1]\n"
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 19,
+   "execution_count": 25,
    "metadata": {},
    "outputs": [
     {
@@ -19356,16 +19098,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.13952238037445452,
-          0.13952758841463156,
-          0.13952757267940874,
-          0.13952758031592874,
-          0.13952758018705966,
-          0.1395275801195493,
-          0.1395275799555333,
-          0.13952757816340494,
-          0.13952758203878637,
-          0.13956100037753522
+          0.13941949429153408,
+          0.1394194942935415,
+          0.13941949429593628,
+          0.13941949429385594,
+          0.13937441406800297,
+          0.1394194942900723,
+          0.13937449778520153,
+          0.1394194942898707,
+          0.13941949429638978,
+          0.13937439364746573
          ]
         },
         {
@@ -19388,16 +19130,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.2381139140133616,
-          0.2377262108730773,
-          0.2377261607545264,
-          0.23772617083589181,
-          0.23772618035749052,
-          0.23772619263673506,
-          0.2377261898054769,
-          0.23772616366644383,
-          0.23772619064535586,
-          0.23823427244549827
+          0.23802628080822757,
+          0.23802628081342103,
+          0.23802628084184677,
+          0.23802628083946228,
+          0.2377561390755645,
+          0.23802628082879476,
+          0.23775627913842876,
+          0.23802628080565053,
+          0.2380262808480914,
+          0.23775610461638583
          ]
         },
         {
@@ -19420,16 +19162,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          0.5500931747887532,
-          0.5505677897145701,
-          0.5505678808304773,
-          0.550567857944485,
-          0.5505678444410829,
-          0.5505678219384629,
-          0.5505678269239426,
-          0.550567873741685,
-          0.5505678236401954,
-          0.5498086486878985
+          0.5503654521585548,
+          0.5503654521485648,
+          0.550365452094803,
+          0.5503654521009591,
+          0.5506120117710778,
+          0.5503654521217981,
+          0.5506117194222369,
+          0.5503654521640418,
+          0.5503654520846756,
+          0.5506120952492668
          ]
         },
         {
@@ -19452,16 +19194,16 @@
          "type": "box",
          "visible": true,
          "y": [
-          2.0486230266915167e-7,
-          1.1592235775976535e-8,
-          1.1592235151122759e-8,
-          1.1592235584007242e-8,
-          1.1592236002316385e-8,
-          1.1592235749879935e-8,
-          1.1592235690922885e-8,
-          1.1592235938733825e-8,
-          1.1592235745577248e-8,
-          7.854735855666878e-24
+          1.9535279492594834e-23,
+          2.3166389170965613e-23,
+          3.282459558371508e-23,
+          3.4059562751946184e-24,
+          1.9053062475082862e-08,
+          4.039578946554816e-23,
+          1.9053067059052494e-08,
+          3.5014584057372714e-23,
+          1.7218179786667206e-23,
+          1.90531137033178e-08
          ]
         },
         {
@@ -19484,16 +19226,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.07455441080382476,
-          0.07455441080422921,
-          0.07455441080442336,
-          0.07455441080398487,
-          0.07455441080415164,
-          0.07471438383609569,
-          0.07455441080455912,
-          0.07455441080414442,
-          0.07455441080535598,
-          0.07455441080478163
+          0.07465792492920492,
+          0.0746579249096991,
+          0.07465792492193521,
+          0.07465792492666053,
+          0.07466209115400987,
+          0.07465792489990465,
+          0.07465792491642866,
+          0.07465792489966043,
+          0.0746579249169771,
+          0.0746579248965519
          ]
         },
         {
@@ -19516,16 +19258,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.06048971641505993,
-          0.06048971641588344,
-          0.06048971641544171,
-          0.06048971641469532,
-          0.060489716415587626,
-          0.06155989038827606,
-          0.06048971641579791,
-          0.060489716414936334,
-          0.060489716416576605,
-          0.06048971641543999
+          0.06047409469502207,
+          0.06047409456573887,
+          0.060474094582372004,
+          0.06047409465011311,
+          0.06050789464556009,
+          0.06047409449265737,
+          0.060474094583610395,
+          0.06047409456744379,
+          0.0604740945822818,
+          0.06047409455519882
          ]
         },
         {
@@ -19548,16 +19290,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.3358240366670577,
-          0.33582403666305216,
-          0.3358240366646475,
-          0.3358240366679628,
-          0.3358240366643596,
-          0.3310733026059061,
-          0.33582403666290866,
-          0.33582403666707045,
-          0.3358240366582904,
-          0.3358240366642503
+          0.3358943179237751,
+          0.33589431849947937,
+          0.3358943184083282,
+          0.33589431811674536,
+          0.33574714729584043,
+          0.33589431882137993,
+          0.33589431842557915,
+          0.33589431851557866,
+          0.33589431841486395,
+          0.3358943185641847
          ]
         },
         {
@@ -19580,16 +19322,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          4.195082114743824e-21,
-          4.194006591058806e-21,
-          4.1961279349692365e-21,
-          4.195734692208734e-21,
-          4.193418746750948e-21,
-          7.232362718082441e-8,
-          4.19611602711445e-21,
-          4.193209752233191e-21,
-          4.201354889527004e-21,
-          4.1968758156401224e-21
+          1.4406177476094372e-21,
+          4.156203775553495e-21,
+          5.150560052222719e-21,
+          5.0633086140723125e-21,
+          7.105876085423447e-11,
+          7.440500345425091e-21,
+          4.228156159362001e-21,
+          4.079206158682102e-21,
+          4.570117912107593e-21,
+          4.37399728203342e-21
          ]
         },
         {
@@ -19612,16 +19354,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.2208905922850747,
-          0.2208913929437088,
-          0.22089086294121354,
-          0.2208927019682394,
-          0.220890155699102,
-          0.2208911282149942,
-          0.22089110719701446,
-          0.2208914010417227,
-          0.06033758363587237,
-          0.22089239011837547
+          0.22089100225568367,
+          0.2208906069907651,
+          0.22089355050515128,
+          0.22088864155801122,
+          0.2208908733411936,
+          0.2208911410047391,
+          0.22089105647610602,
+          0.22089254458091453,
+          0.2208896962036516,
+          0.22089068938355505
          ]
         },
         {
@@ -19644,16 +19386,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          937.2193145509552,
-          941.5798994942752,
-          936.893193904537,
-          945.893664227066,
-          934.210451030678,
-          938.8433076044374,
-          938.3016049516249,
-          940.6493033698013,
-          0.11477489989633834,
-          944.7241535740135
+          938.619152141534,
+          937.885076874349,
+          948.2729488630878,
+          927.7114101852472,
+          937.7294894230971,
+          939.2231725492181,
+          939.1933966275043,
+          943.7233093872404,
+          933.0610803153266,
+          938.1253002496327
          ]
         },
         {
@@ -19676,16 +19418,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.11119413272057536,
-          0.11119349097927847,
-          0.11119408979274648,
-          0.11119276066400344,
-          0.11119455238213875,
-          0.11119384782833085,
-          0.11119391560714659,
-          0.11119359400135985,
-          0.9049659846280953,
-          0.11119294799116626
+          0.11119387669961762,
+          0.1111940886043566,
+          0.11119232117163778,
+          0.11119553680450991,
+          0.11119400038333768,
+          0.11119377968247897,
+          0.11119382321826561,
+          0.11119302073632292,
+          0.11119475422871433,
+          0.1111940215380731
          ]
         },
         {
@@ -19708,16 +19450,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          1.4096679323868144e-9,
-          1.2101490000082694e-9,
-          1.4248724596892424e-9,
-          1.0274077939295006e-9,
-          1.560169568159229e-9,
-          1.3337038214742488e-9,
-          1.3609621371462236e-9,
-          1.2504420645180298e-9,
-          0.28794677994402756,
-          1.0748764655864024e-9
+          1.3425593586271329e-09,
+          1.3841191024302172e-09,
+          9.352893924068188e-10,
+          1.90646559300323e-09,
+          1.3842871668696892e-09,
+          1.3147234801983351e-09,
+          1.3167790977036422e-09,
+          1.1188781457291046e-09,
+          1.6157731721515288e-09,
+          1.367534632292444e-09
          ]
         },
         {
@@ -19740,16 +19482,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.14901045435335528,
-          0.14899746350923354,
-          0.14901045435225374,
-          0.1490066353702117,
-          0.14901045407540278,
-          0.14901045630977316,
-          0.14901045412365885,
-          0.1490104544128475,
-          0.14901045591242093,
-          0.14899576679435553
+          0.14845678435467352,
+          0.14845678435467347,
+          0.1484567843546777,
+          0.14845678435467274,
+          0.14845678435467294,
+          0.14845678435467136,
+          0.14845678435467163,
+          0.148456784354671,
+          0.1484567843546529,
+          0.14845678435467266
          ]
         },
         {
@@ -19772,16 +19514,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          1.1877445449685666,
-          1.1869209688607332,
-          1.1877445361134853,
-          1.1870684956987878,
-          1.1877445376752123,
-          1.1877445869587462,
-          1.1877445160909301,
-          1.1877445410030474,
-          1.1877445477235224,
-          1.1869091275854429
+          1.158602236902154,
+          1.1586022369022364,
+          1.1586022369023763,
+          1.1586022369022904,
+          1.1586022369021993,
+          1.1586022369021645,
+          1.158602236902254,
+          1.1586022369022695,
+          1.1586022369022035,
+          1.1586022369024547
          ]
         },
         {
@@ -19804,16 +19546,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.1084953795963476,
-          0.10852002364379178,
-          0.10849537987244343,
-          0.10851245733524169,
-          0.10849537994941301,
-          0.10849537792237156,
-          0.10849538062711431,
-          0.10849537972013827,
-          0.10849537910300125,
-          0.10852073383890118
+          0.10949226391299757,
+          0.10949226391299596,
+          0.10949226391299091,
+          0.1094922639129953,
+          0.1094922639129979,
+          0.10949226391299888,
+          0.10949226391299643,
+          0.10949226391299624,
+          0.1094922639130055,
+          0.10949226391299012
          ]
         },
         {
@@ -19836,16 +19578,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          2.0541032095052e-9,
-          1.8111212021968598e-10,
-          2.0541031560403797e-9,
-          3.2937191965046066e-10,
-          2.054103154558136e-9,
-          2.0541032012022375e-9,
-          2.0541031883026445e-9,
-          2.054103217446828e-9,
-          2.0541032032993066e-9,
-          1.8015124669415312e-10
+          6.822861050744442e-28,
+          7.37500205464093e-29,
+          1.686375074184574e-28,
+          1.1128793590647204e-29,
+          3.07597975137863e-28,
+          1.0446629204345245e-28,
+          3.2834794435869107e-29,
+          1.690966491171993e-29,
+          6.846713307919689e-27,
+          8.602173800325366e-28
          ]
         },
         {
@@ -19868,16 +19610,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08416667209615447,
-          0.08416595172860288,
-          0.0841681249919099,
-          0.08416849802135681,
-          0.08416658484502194,
-          0.08416733444413829,
-          0.08416660733087476,
-          0.08416688728925666,
-          0.08416566979673375,
-          0.08416667774388847
+          0.08416703651937057,
+          0.0841681674954038,
+          0.08416615826251642,
+          0.08416684503483268,
+          0.08416579369943396,
+          0.08416521111045502,
+          0.08417133596394909,
+          0.08416750820973966,
+          0.08416506996025219,
+          0.08416725144032874
          ]
         },
         {
@@ -19900,16 +19642,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          931.7858621839312,
-          928.6269517244277,
-          939.468523132387,
-          943.1133948645081,
-          930.9319011755997,
-          937.2149555090838,
-          930.0108420176066,
-          932.6731757521716,
-          926.3295326199167,
-          932.406706408712
+          934.6110839119426,
+          941.3870311490342,
+          927.7250000792607,
+          931.4467485841127,
+          927.445607448814,
+          923.1346165664186,
+          961.922191401744,
+          936.5161092529213,
+          922.6570401957257,
+          936.9739743472036
          ]
         },
         {
@@ -19932,16 +19674,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.10837413747073456,
-          0.10837465101255483,
-          0.10837296457130761,
-          0.10837254314435982,
-          0.1083742166738031,
-          0.10837347670576744,
-          0.10837428082929784,
-          0.10837396107773417,
-          0.10837493461383858,
-          0.108374074810415
+          0.10837377293678474,
+          0.10837282016525071,
+          0.10837463114133707,
+          0.10837407666987713,
+          0.10837479322776321,
+          0.10837537655815697,
+          0.10837006851752859,
+          0.10837343812544177,
+          0.10837546269935446,
+          0.10837350935091311
          ]
         },
         {
@@ -19964,16 +19706,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          1.817210775837478e-9,
-          2.0007561375887497e-9,
-          1.4091989381935081e-9,
-          1.2316784882957028e-9,
-          1.8630134739676265e-9,
-          1.5242350511082555e-9,
-          1.920500076409589e-9,
-          1.7638856403863322e-9,
-          2.1408954466056496e-9,
-          1.778662336622915e-9
+          1.6574231840976273e-09,
+          1.3135179290289341e-09,
+          2.0555084798113287e-09,
+          1.8372998284455756e-09,
+          2.0727935666924354e-09,
+          2.3489728304768556e-09,
+          5.31283750015558e-10,
+          1.5569591081210712e-09,
+          2.3791214447090633e-09,
+          1.533062285670624e-09
          ]
         },
         {
@@ -19996,16 +19738,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.13324572357191233,
-          0.13324572012213717,
-          0.13324572434138549,
-          0.13327412171312955,
-          0.13324572553596145,
-          0.13324572377324492,
-          0.13324572400091828,
-          0.1332457228269579,
-          0.13324572342207455,
-          0.13327412171311895
+          0.13327413294382767,
+          0.13324573708065623,
+          0.13327413294334928,
+          0.1332741329438668,
+          0.1332741329441626,
+          0.133274132943881,
+          0.13324573491181993,
+          0.13324573476502327,
+          0.1332457365344882,
+          0.13324573685036997
          ]
         },
         {
@@ -20028,16 +19770,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.27465719745897804,
-          0.2746571896994581,
-          0.27465720864253035,
-          0.27497248713899847,
-          0.2746572137407111,
-          0.2746571992187518,
-          0.27465719789382204,
-          0.27465720196728,
-          0.2746572056056098,
-          0.27497248713896755
+          0.2749725204151676,
+          0.27465724008525766,
+          0.2749725204270669,
+          0.27497252041525666,
+          0.2749725204238099,
+          0.27497252041535314,
+          0.2746572402946828,
+          0.2746572319242068,
+          0.27465724206851744,
+          0.2746572439115948
          ]
         },
         {
@@ -20060,16 +19802,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.39518516239711693,
-          0.39518517256715796,
-          0.39518515129236126,
-          0.3947191393354235,
-          0.3951851446546237,
-          0.3951851606847147,
-          0.39518516191431113,
-          0.3951851582662538,
-          0.3951851539969372,
-          0.3947191393354546
+          0.3947191328483191,
+          0.39518514501071633,
+          0.39471913283889,
+          0.3947191328482067,
+          0.39471913284217147,
+          0.39471913284810484,
+          0.39518514461698334,
+          0.3951851538983224,
+          0.395185142723576,
+          0.39518514040986286
          ]
         },
         {
@@ -20092,16 +19834,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          9.76339827083392e-9,
-          9.763398354804133e-9,
-          9.763398344282205e-9,
-          1.2425021480417589e-28,
-          9.763398404677993e-9,
-          9.763398352786179e-9,
-          9.763398362762709e-9,
-          9.763398350761785e-9,
-          9.76339841570709e-9,
-          1.2377512640549445e-27
+          3.1596334159194063e-23,
+          9.763488361922037e-09,
+          2.0682340633024437e-23,
+          3.1584421244796974e-23,
+          1.8027818974590344e-23,
+          3.1587200377114165e-23,
+          9.763488451011561e-09,
+          9.763488392129775e-09,
+          9.76348836165004e-09,
+          9.763488393849765e-09
          ]
         },
         {
@@ -20124,16 +19866,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.12332984325963313,
-          0.12332984325961999,
-          0.12332984325963203,
-          0.12332984325963313,
-          0.12332984325962043,
-          0.12332984325947928,
-          0.12332984325910312,
-          0.12332984325963138,
-          0.12332984325962656,
-          0.12332984325967783
+          0.12380947161166297,
+          0.1238094716116964,
+          0.12380947161119409,
+          0.12380947161166667,
+          0.12380947161161976,
+          0.1238094716116252,
+          0.12380947161161306,
+          0.12380947161167397,
+          0.12380947161162471,
+          0.12380947161157853
          ]
         },
         {
@@ -20156,16 +19898,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.820240444779477,
-          0.820240444779168,
-          0.8202404447792592,
-          0.8202404447794143,
-          0.8202404447790778,
-          0.8202404448013166,
-          0.820240444775717,
-          0.8202404447793522,
-          0.8202404447791185,
-          0.820240444781597
+          0.8481579376272455,
+          0.8481579376266262,
+          0.8481579376754262,
+          0.8481579376290518,
+          0.8481579376264936,
+          0.8481579376277246,
+          0.8481579376286933,
+          0.8481579376299143,
+          0.8481579376284357,
+          0.8481579376285198
          ]
         },
         {
@@ -20188,16 +19930,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08704230651742025,
-          0.08704230651743369,
-          0.08704230651742696,
-          0.0870423065174213,
-          0.08704230651743818,
-          0.08704230651742935,
-          0.0870423065183214,
-          0.08704230651742398,
-          0.0870423065174316,
-          0.08704230651734415
+          0.08606324249865886,
+          0.08606324249867003,
+          0.0860632424985401,
+          0.08606324249861466,
+          0.08606324249871009,
+          0.08606324249865886,
+          0.08606324249864344,
+          0.08606324249858416,
+          0.0860632424986503,
+          0.08606324249866368
          ]
         },
         {
@@ -20220,16 +19962,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          2.4877237091649926e-30,
-          7.729999091640107e-28,
-          1.7683811712165824e-28,
-          1.0792333629362754e-29,
-          1.4174412982382513e-27,
-          1.2462334986420532e-24,
-          1.487320521611929e-24,
-          2.5735816660857755e-29,
-          5.593919375441114e-28,
-          1.2477707990348224e-26
+          8.417680184089735e-24,
+          8.459431008803015e-24,
+          4.1619667168063266e-24,
+          8.446925075924145e-24,
+          8.516141293484829e-24,
+          8.448824868688071e-24,
+          8.464637356925342e-24,
+          8.447793195779926e-24,
+          8.461777905625751e-24,
+          8.508019824094903e-24
          ]
         },
         {
@@ -20252,16 +19994,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.08704782573719047,
-          0.08704782573727421,
-          0.08704782573727336,
-          0.08704782573723721,
-          0.08704782573727336,
-          0.08704782573724336,
-          0.0870478257372732,
-          0.08704782573739257,
-          0.08704782573727633,
-          0.08704782573727177
+          0.08704782268067632,
+          0.08704782268062707,
+          0.08704782268072085,
+          0.08704782268043953,
+          0.08704782268061849,
+          0.08704782268065393,
+          0.08704782268069812,
+          0.0870478226805605,
+          0.08704782268064709,
+          0.0870478226806561
          ]
         },
         {
@@ -20284,16 +20026,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          2.671369777725151,
-          2.671369777762099,
-          2.671369777762963,
-          2.671369777759126,
-          2.671369777760089,
-          2.6713697777463965,
-          2.671369777762718,
-          2.6713697778151206,
-          2.671369777764156,
-          2.671369777763743
+          2.6713696863832403,
+          2.6713696863853573,
+          2.6713696863985668,
+          2.6713696862811864,
+          2.671369686387976,
+          2.6713696863781466,
+          2.6713696863905723,
+          2.671369686312682,
+          2.6713696863752543,
+          2.671369686394689
          ]
         },
         {
@@ -20316,16 +20058,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          0.0723443112595651,
-          0.07234431125944175,
-          0.07234431125943867,
-          0.07234431125946815,
-          0.07234431125944506,
-          0.0723443112594933,
-          0.07234431125943991,
-          0.07234431125921745,
-          0.07234431125943502,
-          0.07234431125943772
+          0.07234431261003911,
+          0.07234431261005761,
+          0.0723443126099948,
+          0.07234431261038185,
+          0.07234431261011069,
+          0.07234431261006084,
+          0.07234431261001863,
+          0.07234431261025266,
+          0.07234431261006764,
+          0.0723443126100718
          ]
         },
         {
@@ -20348,16 +20090,16 @@
          "type": "box",
          "visible": false,
          "y": [
-          2.7261430626280234e-25,
-          2.295176114672848e-25,
-          2.269488030259732e-25,
-          2.477348293146271e-25,
-          2.281058584031373e-25,
-          2.434683987534417e-25,
-          2.277434026246495e-25,
-          1.1989081864160993e-25,
-          2.2748927828701054e-25,
-          2.2710417029829584e-25
+          1.641859899821985e-27,
+          2.5258034656556092e-26,
+          9.189852159852185e-26,
+          2.697447759940333e-25,
+          2.2675931097133793e-25,
+          2.1762584666988e-28,
+          3.064823551804874e-26,
+          1.1060701682647212e-25,
+          5.867307442162815e-27,
+          2.650354246864696e-25
          ]
         }
        ],
@@ -21538,20 +21280,20 @@
        "<div>\n",
        "        \n",
        "        \n",
-       "            <div id=\"0fdda58f-9090-4fbc-9f22-f27341c944d3\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
+       "            <div id=\"95cef037-0419-4107-9b3b-8f11582186e0\" class=\"plotly-graph-div\" style=\"height:525px; width:100%;\"></div>\n",
        "            <script type=\"text/javascript\">\n",
        "                require([\"plotly\"], function(Plotly) {\n",
        "                    window.PLOTLYENV=window.PLOTLYENV || {};\n",
        "                    \n",
-       "                if (document.getElementById(\"0fdda58f-9090-4fbc-9f22-f27341c944d3\")) {\n",
+       "                if (document.getElementById(\"95cef037-0419-4107-9b3b-8f11582186e0\")) {\n",
        "                    Plotly.newPlot(\n",
-       "                        '0fdda58f-9090-4fbc-9f22-f27341c944d3',\n",
-       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13952238037445452, 0.13952758841463156, 0.13952757267940874, 0.13952758031592874, 0.13952758018705966, 0.1395275801195493, 0.1395275799555333, 0.13952757816340494, 0.13952758203878637, 0.13956100037753522]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.2381139140133616, 0.2377262108730773, 0.2377261607545264, 0.23772617083589181, 0.23772618035749052, 0.23772619263673506, 0.2377261898054769, 0.23772616366644383, 0.23772619064535586, 0.23823427244549827]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.5500931747887532, 0.5505677897145701, 0.5505678808304773, 0.550567857944485, 0.5505678444410829, 0.5505678219384629, 0.5505678269239426, 0.550567873741685, 0.5505678236401954, 0.5498086486878985]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [2.0486230266915167e-07, 1.1592235775976535e-08, 1.1592235151122759e-08, 1.1592235584007242e-08, 1.1592236002316385e-08, 1.1592235749879935e-08, 1.1592235690922885e-08, 1.1592235938733825e-08, 1.1592235745577248e-08, 7.854735855666878e-24]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07455441080382476, 0.07455441080422921, 0.07455441080442336, 0.07455441080398487, 0.07455441080415164, 0.07471438383609569, 0.07455441080455912, 0.07455441080414442, 0.07455441080535598, 0.07455441080478163]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.06048971641505993, 0.06048971641588344, 0.06048971641544171, 0.06048971641469532, 0.060489716415587626, 0.06155989038827606, 0.06048971641579791, 0.060489716414936334, 0.060489716416576605, 0.06048971641543999]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.3358240366670577, 0.33582403666305216, 0.3358240366646475, 0.3358240366679628, 0.3358240366643596, 0.3310733026059061, 0.33582403666290866, 0.33582403666707045, 0.3358240366582904, 0.3358240366642503]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [4.195082114743824e-21, 4.194006591058806e-21, 4.1961279349692365e-21, 4.195734692208734e-21, 4.193418746750948e-21, 7.232362718082441e-08, 4.19611602711445e-21, 4.193209752233191e-21, 4.201354889527004e-21, 4.1968758156401224e-21]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2208905922850747, 0.2208913929437088, 0.22089086294121354, 0.2208927019682394, 0.220890155699102, 0.2208911282149942, 0.22089110719701446, 0.2208914010417227, 0.06033758363587237, 0.22089239011837547]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [937.2193145509552, 941.5798994942752, 936.893193904537, 945.893664227066, 934.210451030678, 938.8433076044374, 938.3016049516249, 940.6493033698013, 0.11477489989633834, 944.7241535740135]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.11119413272057536, 0.11119349097927847, 0.11119408979274648, 0.11119276066400344, 0.11119455238213875, 0.11119384782833085, 0.11119391560714659, 0.11119359400135985, 0.9049659846280953, 0.11119294799116626]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.4096679323868144e-09, 1.2101490000082694e-09, 1.4248724596892424e-09, 1.0274077939295006e-09, 1.560169568159229e-09, 1.3337038214742488e-09, 1.3609621371462236e-09, 1.2504420645180298e-09, 0.28794677994402756, 1.0748764655864024e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14901045435335528, 0.14899746350923354, 0.14901045435225374, 0.1490066353702117, 0.14901045407540278, 0.14901045630977316, 0.14901045412365885, 0.1490104544128475, 0.14901045591242093, 0.14899576679435553]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.1877445449685666, 1.1869209688607332, 1.1877445361134853, 1.1870684956987878, 1.1877445376752123, 1.1877445869587462, 1.1877445160909301, 1.1877445410030474, 1.1877445477235224, 1.1869091275854429]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.1084953795963476, 0.10852002364379178, 0.10849537987244343, 0.10851245733524169, 0.10849537994941301, 0.10849537792237156, 0.10849538062711431, 0.10849537972013827, 0.10849537910300125, 0.10852073383890118]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.0541032095052e-09, 1.8111212021968598e-10, 2.0541031560403797e-09, 3.2937191965046066e-10, 2.054103154558136e-09, 2.0541032012022375e-09, 2.0541031883026445e-09, 2.054103217446828e-09, 2.0541032032993066e-09, 1.8015124669415312e-10]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08416667209615447, 0.08416595172860288, 0.0841681249919099, 0.08416849802135681, 0.08416658484502194, 0.08416733444413829, 0.08416660733087476, 0.08416688728925666, 0.08416566979673375, 0.08416667774388847]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [931.7858621839312, 928.6269517244277, 939.468523132387, 943.1133948645081, 930.9319011755997, 937.2149555090838, 930.0108420176066, 932.6731757521716, 926.3295326199167, 932.406706408712]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10837413747073456, 0.10837465101255483, 0.10837296457130761, 0.10837254314435982, 0.1083742166738031, 0.10837347670576744, 0.10837428082929784, 0.10837396107773417, 0.10837493461383858, 0.108374074810415]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.817210775837478e-09, 2.0007561375887497e-09, 1.4091989381935081e-09, 1.2316784882957028e-09, 1.8630134739676265e-09, 1.5242350511082555e-09, 1.920500076409589e-09, 1.7638856403863322e-09, 2.1408954466056496e-09, 1.778662336622915e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13324572357191233, 0.13324572012213717, 0.13324572434138549, 0.13327412171312955, 0.13324572553596145, 0.13324572377324492, 0.13324572400091828, 0.1332457228269579, 0.13324572342207455, 0.13327412171311895]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.27465719745897804, 0.2746571896994581, 0.27465720864253035, 0.27497248713899847, 0.2746572137407111, 0.2746571992187518, 0.27465719789382204, 0.27465720196728, 0.2746572056056098, 0.27497248713896755]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.39518516239711693, 0.39518517256715796, 0.39518515129236126, 0.3947191393354235, 0.3951851446546237, 0.3951851606847147, 0.39518516191431113, 0.3951851582662538, 0.3951851539969372, 0.3947191393354546]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [9.76339827083392e-09, 9.763398354804133e-09, 9.763398344282205e-09, 1.2425021480417589e-28, 9.763398404677993e-09, 9.763398352786179e-09, 9.763398362762709e-09, 9.763398350761785e-09, 9.76339841570709e-09, 1.2377512640549445e-27]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12332984325963313, 0.12332984325961999, 0.12332984325963203, 0.12332984325963313, 0.12332984325962043, 0.12332984325947928, 0.12332984325910312, 0.12332984325963138, 0.12332984325962656, 0.12332984325967783]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.820240444779477, 0.820240444779168, 0.8202404447792592, 0.8202404447794143, 0.8202404447790778, 0.8202404448013166, 0.820240444775717, 0.8202404447793522, 0.8202404447791185, 0.820240444781597]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704230651742025, 0.08704230651743369, 0.08704230651742696, 0.0870423065174213, 0.08704230651743818, 0.08704230651742935, 0.0870423065183214, 0.08704230651742398, 0.0870423065174316, 0.08704230651734415]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.4877237091649926e-30, 7.729999091640107e-28, 1.7683811712165824e-28, 1.0792333629362754e-29, 1.4174412982382513e-27, 1.2462334986420532e-24, 1.487320521611929e-24, 2.5735816660857755e-29, 5.593919375441114e-28, 1.2477707990348224e-26]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704782573719047, 0.08704782573727421, 0.08704782573727336, 0.08704782573723721, 0.08704782573727336, 0.08704782573724336, 0.0870478257372732, 0.08704782573739257, 0.08704782573727633, 0.08704782573727177]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.671369777725151, 2.671369777762099, 2.671369777762963, 2.671369777759126, 2.671369777760089, 2.6713697777463965, 2.671369777762718, 2.6713697778151206, 2.671369777764156, 2.671369777763743]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.0723443112595651, 0.07234431125944175, 0.07234431125943867, 0.07234431125946815, 0.07234431125944506, 0.0723443112594933, 0.07234431125943991, 0.07234431125921745, 0.07234431125943502, 0.07234431125943772]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.7261430626280234e-25, 2.295176114672848e-25, 2.269488030259732e-25, 2.477348293146271e-25, 2.281058584031373e-25, 2.434683987534417e-25, 2.277434026246495e-25, 1.1989081864160993e-25, 2.2748927828701054e-25, 2.2710417029829584e-25]}],\n",
+       "                        '95cef037-0419-4107-9b3b-8f11582186e0',\n",
+       "                        [{\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.13941949429153408, 0.1394194942935415, 0.13941949429593628, 0.13941949429385594, 0.13937441406800297, 0.1394194942900723, 0.13937449778520153, 0.1394194942898707, 0.13941949429638978, 0.13937439364746573]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.23802628080822757, 0.23802628081342103, 0.23802628084184677, 0.23802628083946228, 0.2377561390755645, 0.23802628082879476, 0.23775627913842876, 0.23802628080565053, 0.2380262808480914, 0.23775610461638583]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [0.5503654521585548, 0.5503654521485648, 0.550365452094803, 0.5503654521009591, 0.5506120117710778, 0.5503654521217981, 0.5506117194222369, 0.5503654521640418, 0.5503654520846756, 0.5506120952492668]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": true, \"y\": [1.9535279492594834e-23, 2.3166389170965613e-23, 3.282459558371508e-23, 3.4059562751946184e-24, 1.9053062475082862e-08, 4.039578946554816e-23, 1.9053067059052494e-08, 3.5014584057372714e-23, 1.7218179786667206e-23, 1.90531137033178e-08]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07465792492920492, 0.0746579249096991, 0.07465792492193521, 0.07465792492666053, 0.07466209115400987, 0.07465792489990465, 0.07465792491642866, 0.07465792489966043, 0.0746579249169771, 0.0746579248965519]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.06047409469502207, 0.06047409456573887, 0.060474094582372004, 0.06047409465011311, 0.06050789464556009, 0.06047409449265737, 0.060474094583610395, 0.06047409456744379, 0.0604740945822818, 0.06047409455519882]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.3358943179237751, 0.33589431849947937, 0.3358943184083282, 0.33589431811674536, 0.33574714729584043, 0.33589431882137993, 0.33589431842557915, 0.33589431851557866, 0.33589431841486395, 0.3358943185641847]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.4406177476094372e-21, 4.156203775553495e-21, 5.150560052222719e-21, 5.0633086140723125e-21, 7.105876085423447e-11, 7.440500345425091e-21, 4.228156159362001e-21, 4.079206158682102e-21, 4.570117912107593e-21, 4.37399728203342e-21]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.22089100225568367, 0.2208906069907651, 0.22089355050515128, 0.22088864155801122, 0.2208908733411936, 0.2208911410047391, 0.22089105647610602, 0.22089254458091453, 0.2208896962036516, 0.22089068938355505]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [938.619152141534, 937.885076874349, 948.2729488630878, 927.7114101852472, 937.7294894230971, 939.2231725492181, 939.1933966275043, 943.7233093872404, 933.0610803153266, 938.1253002496327]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.11119387669961762, 0.1111940886043566, 0.11119232117163778, 0.11119553680450991, 0.11119400038333768, 0.11119377968247897, 0.11119382321826561, 0.11119302073632292, 0.11119475422871433, 0.1111940215380731]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.3425593586271329e-09, 1.3841191024302172e-09, 9.352893924068188e-10, 1.90646559300323e-09, 1.3842871668696892e-09, 1.3147234801983351e-09, 1.3167790977036422e-09, 1.1188781457291046e-09, 1.6157731721515288e-09, 1.367534632292444e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.14845678435467352, 0.14845678435467347, 0.1484567843546777, 0.14845678435467274, 0.14845678435467294, 0.14845678435467136, 0.14845678435467163, 0.148456784354671, 0.1484567843546529, 0.14845678435467266]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.158602236902154, 1.1586022369022364, 1.1586022369023763, 1.1586022369022904, 1.1586022369021993, 1.1586022369021645, 1.158602236902254, 1.1586022369022695, 1.1586022369022035, 1.1586022369024547]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10949226391299757, 0.10949226391299596, 0.10949226391299091, 0.1094922639129953, 0.1094922639129979, 0.10949226391299888, 0.10949226391299643, 0.10949226391299624, 0.1094922639130055, 0.10949226391299012]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [6.822861050744442e-28, 7.37500205464093e-29, 1.686375074184574e-28, 1.1128793590647204e-29, 3.07597975137863e-28, 1.0446629204345245e-28, 3.2834794435869107e-29, 1.690966491171993e-29, 6.846713307919689e-27, 8.602173800325366e-28]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08416703651937057, 0.0841681674954038, 0.08416615826251642, 0.08416684503483268, 0.08416579369943396, 0.08416521111045502, 0.08417133596394909, 0.08416750820973966, 0.08416506996025219, 0.08416725144032874]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [934.6110839119426, 941.3870311490342, 927.7250000792607, 931.4467485841127, 927.445607448814, 923.1346165664186, 961.922191401744, 936.5161092529213, 922.6570401957257, 936.9739743472036]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.10837377293678474, 0.10837282016525071, 0.10837463114133707, 0.10837407666987713, 0.10837479322776321, 0.10837537655815697, 0.10837006851752859, 0.10837343812544177, 0.10837546269935446, 0.10837350935091311]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.6574231840976273e-09, 1.3135179290289341e-09, 2.0555084798113287e-09, 1.8372998284455756e-09, 2.0727935666924354e-09, 2.3489728304768556e-09, 5.31283750015558e-10, 1.5569591081210712e-09, 2.3791214447090633e-09, 1.533062285670624e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.13327413294382767, 0.13324573708065623, 0.13327413294334928, 0.1332741329438668, 0.1332741329441626, 0.133274132943881, 0.13324573491181993, 0.13324573476502327, 0.1332457365344882, 0.13324573685036997]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.2749725204151676, 0.27465724008525766, 0.2749725204270669, 0.27497252041525666, 0.2749725204238099, 0.27497252041535314, 0.2746572402946828, 0.2746572319242068, 0.27465724206851744, 0.2746572439115948]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.3947191328483191, 0.39518514501071633, 0.39471913283889, 0.3947191328482067, 0.39471913284217147, 0.39471913284810484, 0.39518514461698334, 0.3951851538983224, 0.395185142723576, 0.39518514040986286]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [3.1596334159194063e-23, 9.763488361922037e-09, 2.0682340633024437e-23, 3.1584421244796974e-23, 1.8027818974590344e-23, 3.1587200377114165e-23, 9.763488451011561e-09, 9.763488392129775e-09, 9.76348836165004e-09, 9.763488393849765e-09]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.12380947161166297, 0.1238094716116964, 0.12380947161119409, 0.12380947161166667, 0.12380947161161976, 0.1238094716116252, 0.12380947161161306, 0.12380947161167397, 0.12380947161162471, 0.12380947161157853]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.8481579376272455, 0.8481579376266262, 0.8481579376754262, 0.8481579376290518, 0.8481579376264936, 0.8481579376277246, 0.8481579376286933, 0.8481579376299143, 0.8481579376284357, 0.8481579376285198]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08606324249865886, 0.08606324249867003, 0.0860632424985401, 0.08606324249861466, 0.08606324249871009, 0.08606324249865886, 0.08606324249864344, 0.08606324249858416, 0.0860632424986503, 0.08606324249866368]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [8.417680184089735e-24, 8.459431008803015e-24, 4.1619667168063266e-24, 8.446925075924145e-24, 8.516141293484829e-24, 8.448824868688071e-24, 8.464637356925342e-24, 8.447793195779926e-24, 8.461777905625751e-24, 8.508019824094903e-24]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#636EFA\"}, \"marker\": {\"color\": \"#636EFA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Initial tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.08704782268067632, 0.08704782268062707, 0.08704782268072085, 0.08704782268043953, 0.08704782268061849, 0.08704782268065393, 0.08704782268069812, 0.0870478226805605, 0.08704782268064709, 0.0870478226806561]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#EF553B\"}, \"marker\": {\"color\": \"#EF553B\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Critical tumour volume in cm^3\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [2.6713696863832403, 2.6713696863853573, 2.6713696863985668, 2.6713696862811864, 2.671369686387976, 2.6713696863781466, 2.6713696863905723, 2.671369686312682, 2.6713696863752543, 2.671369686394689]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#00CC96\"}, \"marker\": {\"color\": \"#00CC96\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Growth rate in 1/day\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [0.07234431261003911, 0.07234431261005761, 0.0723443126099948, 0.07234431261038185, 0.07234431261011069, 0.07234431261006084, 0.07234431261001863, 0.07234431261025266, 0.07234431261006764, 0.0723443126100718]}, {\"boxpoints\": \"all\", \"jitter\": 0.2, \"line\": {\"color\": \"#AB63FA\"}, \"marker\": {\"color\": \"#AB63FA\", \"line\": {\"color\": \"black\", \"width\": 1}, \"opacity\": 0.7, \"symbol\": \"circle\"}, \"name\": \"Objective function score\", \"pointpos\": -1.5, \"type\": \"box\", \"visible\": false, \"y\": [1.641859899821985e-27, 2.5258034656556092e-26, 9.189852159852185e-26, 2.697447759940333e-25, 2.2675931097133793e-25, 2.1762584666988e-28, 3.064823551804874e-26, 1.1060701682647212e-25, 5.867307442162815e-27, 2.650354246864696e-25]}],\n",
        "                        {\"autosize\": true, \"legend\": {\"x\": 1.05, \"xanchor\": \"left\", \"y\": 0.01, \"yanchor\": \"bottom\"}, \"template\": {\"data\": {\"bar\": [{\"error_x\": {\"color\": \"#2a3f5f\"}, \"error_y\": {\"color\": \"#2a3f5f\"}, \"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"bar\"}], \"barpolar\": [{\"marker\": {\"line\": {\"color\": \"white\", \"width\": 0.5}}, \"type\": \"barpolar\"}], \"carpet\": [{\"aaxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"baxis\": {\"endlinecolor\": \"#2a3f5f\", \"gridcolor\": \"#C8D4E3\", \"linecolor\": \"#C8D4E3\", \"minorgridcolor\": \"#C8D4E3\", \"startlinecolor\": \"#2a3f5f\"}, \"type\": \"carpet\"}], \"choropleth\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"choropleth\"}], \"contour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"contour\"}], \"contourcarpet\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"contourcarpet\"}], \"heatmap\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmap\"}], \"heatmapgl\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"heatmapgl\"}], \"histogram\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"histogram\"}], \"histogram2d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2d\"}], \"histogram2dcontour\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"histogram2dcontour\"}], \"mesh3d\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"type\": \"mesh3d\"}], \"parcoords\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"parcoords\"}], \"pie\": [{\"automargin\": true, \"type\": \"pie\"}], \"scatter\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter\"}], \"scatter3d\": [{\"line\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatter3d\"}], \"scattercarpet\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattercarpet\"}], \"scattergeo\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergeo\"}], \"scattergl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattergl\"}], \"scattermapbox\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scattermapbox\"}], \"scatterpolar\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolar\"}], \"scatterpolargl\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterpolargl\"}], \"scatterternary\": [{\"marker\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"type\": \"scatterternary\"}], \"surface\": [{\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}, \"colorscale\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"type\": \"surface\"}], \"table\": [{\"cells\": {\"fill\": {\"color\": \"#EBF0F8\"}, \"line\": {\"color\": \"white\"}}, \"header\": {\"fill\": {\"color\": \"#C8D4E3\"}, \"line\": {\"color\": \"white\"}}, \"type\": \"table\"}]}, \"layout\": {\"annotationdefaults\": {\"arrowcolor\": \"#2a3f5f\", \"arrowhead\": 0, \"arrowwidth\": 1}, \"coloraxis\": {\"colorbar\": {\"outlinewidth\": 0, \"ticks\": \"\"}}, \"colorscale\": {\"diverging\": [[0, \"#8e0152\"], [0.1, \"#c51b7d\"], [0.2, \"#de77ae\"], [0.3, \"#f1b6da\"], [0.4, \"#fde0ef\"], [0.5, \"#f7f7f7\"], [0.6, \"#e6f5d0\"], [0.7, \"#b8e186\"], [0.8, \"#7fbc41\"], [0.9, \"#4d9221\"], [1, \"#276419\"]], \"sequential\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]], \"sequentialminus\": [[0.0, \"#0d0887\"], [0.1111111111111111, \"#46039f\"], [0.2222222222222222, \"#7201a8\"], [0.3333333333333333, \"#9c179e\"], [0.4444444444444444, \"#bd3786\"], [0.5555555555555556, \"#d8576b\"], [0.6666666666666666, \"#ed7953\"], [0.7777777777777778, \"#fb9f3a\"], [0.8888888888888888, \"#fdca26\"], [1.0, \"#f0f921\"]]}, \"colorway\": [\"#636efa\", \"#EF553B\", \"#00cc96\", \"#ab63fa\", \"#FFA15A\", \"#19d3f3\", \"#FF6692\", \"#B6E880\", \"#FF97FF\", \"#FECB52\"], \"font\": {\"color\": \"#2a3f5f\"}, \"geo\": {\"bgcolor\": \"white\", \"lakecolor\": \"white\", \"landcolor\": \"white\", \"showlakes\": true, \"showland\": true, \"subunitcolor\": \"#C8D4E3\"}, \"hoverlabel\": {\"align\": \"left\"}, \"hovermode\": \"closest\", \"mapbox\": {\"style\": \"light\"}, \"paper_bgcolor\": \"white\", \"plot_bgcolor\": \"white\", \"polar\": {\"angularaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"radialaxis\": {\"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\"}}, \"scene\": {\"xaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"yaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}, \"zaxis\": {\"backgroundcolor\": \"white\", \"gridcolor\": \"#DFE8F3\", \"gridwidth\": 2, \"linecolor\": \"#EBF0F8\", \"showbackground\": true, \"ticks\": \"\", \"zerolinecolor\": \"#EBF0F8\"}}, \"shapedefaults\": {\"line\": {\"color\": \"#2a3f5f\"}}, \"ternary\": {\"aaxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"baxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}, \"bgcolor\": \"white\", \"caxis\": {\"gridcolor\": \"#DFE8F3\", \"linecolor\": \"#A2B1C6\", \"ticks\": \"\"}}, \"title\": {\"x\": 0.05}, \"xaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}, \"yaxis\": {\"automargin\": true, \"gridcolor\": \"#EBF0F8\", \"linecolor\": \"#EBF0F8\", \"ticks\": \"\", \"title\": {\"standoff\": 15}, \"zerolinecolor\": \"#EBF0F8\", \"zerolinewidth\": 2}}}, \"updatemenus\": [{\"buttons\": [{\"args\": [{\"visible\": [true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 40\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 94\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 95\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 136\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 140\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false, false, false, false, false]}], \"label\": \"ID: 155\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true, false, false, false, false]}], \"label\": \"ID: 169\", \"method\": \"restyle\"}, {\"args\": [{\"visible\": [false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, false, true, true, true, true]}], \"label\": \"ID: 170\", \"method\": \"restyle\"}], \"direction\": \"right\", \"pad\": {\"r\": 0, \"t\": -10}, \"showactive\": true, \"type\": \"buttons\", \"x\": 0.0, \"xanchor\": \"left\", \"y\": 1.1, \"yanchor\": \"top\"}], \"yaxis\": {\"title\": {\"text\": \"Estimates\"}}},\n",
        "                        {\"responsive\": true}\n",
        "                    ).then(function(){\n",
        "                            \n",
-       "var gd = document.getElementById('0fdda58f-9090-4fbc-9f22-f27341c944d3');\n",
+       "var gd = document.getElementById('95cef037-0419-4107-9b3b-8f11582186e0');\n",
        "var x = new MutationObserver(function (mutations, observer) {{\n",
        "        var display = window.getComputedStyle(gd).display;\n",
        "        if (!display || display === 'none') {{\n",
@@ -22918,4 +22660,4 @@
  },
  "nbformat": 4,
  "nbformat_minor": 2
-}
\ No newline at end of file
+}
diff --git a/pkpd/__init__.py b/pkpd/__init__.py
index 52948fa..74b3347 100644
--- a/pkpd/__init__.py
+++ b/pkpd/__init__.py
@@ -17,6 +17,10 @@ from ._models import (  # noqa
     PharmacodynamicModel
 )
 
+from ._optimisation import (  # noqa
+    optimise
+)
+
 
 class ModelLibrary(object):
     """
diff --git a/pkpd/_optimisation.py b/pkpd/_optimisation.py
new file mode 100644
index 0000000..cf2cbdd
--- /dev/null
+++ b/pkpd/_optimisation.py
@@ -0,0 +1,67 @@
+#
+# This file is part of the ErlotinibGefitinib repository
+# (https://github.com/DavAug/ErlotinibGefitinib/) which is released under the
+# BSD 3-clause license. See accompanying LICENSE.md for copyright notice and
+# full license details.
+#
+
+import numpy as np
+import pints
+
+
+def optimise(
+        objective_function, optimiser, initial_params, n_runs=1,
+        boundaries=None):
+    """
+    Returns parameters that optimise the objective function.
+    """
+    if not isinstance(objective_function, (pints.ErrorMeasure, pints.LogPDF)):
+        raise ValueError(
+            'Objective function has to be an instance of `pints.ErrorMeasure` '
+            'or pints.LogPDF.')
+    if not issubclass(optimiser, pints.Optimiser):
+        raise ValueError(
+            'Optimiser has to be an instance of `pints.Optimiser`.')
+
+    n_parameters = objective_function.n_parameters()
+    initial_params = np.asarray(initial_params)
+    if initial_params.shape != (n_runs, n_parameters):
+        raise ValueError(
+            'Initial parameters has the wrong shape! Expected shape = '
+            '(%d, %d).' % (n_runs, n_parameters))
+    if boundaries is not None:
+        if not isinstance(boundaries, pints.Boundaries):
+            raise ValueError(
+                'Boundaries have to be an instance of `pints.Bouandries`.')
+
+    # Define container for estimates and scores
+    parameters = np.empty(shape=(n_runs, n_parameters))
+    scores = np.empty(shape=n_runs)
+
+    # Run optimisation multiple times
+    for run_id, init_p in enumerate(initial_params):
+        opt = pints.OptimisationController(
+            function=objective_function,
+            x0=init_p,
+            method=optimiser,
+            boundaries=boundaries)
+
+        # Disable logging mode
+        opt.set_log_to_screen(False)
+
+        # Parallelise optimisation
+        opt.set_parallel(True)
+
+        # Find optimal parameters
+        try:
+            estimates, score = opt.run()
+        except Exception:
+            # If inference breaks fill estimates with nan
+            estimates = np.array([np.nan] * n_parameters)
+            score = np.nan
+
+        # Save estimates and score
+        parameters[run_id, :] = estimates
+        scores[run_id] = score
+
+    return parameters, scores


Test patch:
diff --git a/pkpd/tests/test_optimisation.py b/pkpd/tests/test_optimisation.py
new file mode 100644
index 0000000..9bd801f
--- /dev/null
+++ b/pkpd/tests/test_optimisation.py
@@ -0,0 +1,100 @@
+#
+# This file is part of the ErlotinibGefitinib repository
+# (https://github.com/DavAug/ErlotinibGefitinib/) which is released under the
+# BSD 3-clause license. See accompanying LICENSE.md for copyright notice and
+# full license details.
+#
+
+import unittest
+
+import numpy as np
+import pints
+import pints.toy
+
+import pkpd
+
+
+# Unit testing in Python 2 and 3
+try:
+    unittest.TestCase.assertRaisesRegex
+except AttributeError:  # pragma: no python 3 cover
+    unittest.TestCase.assertRaisesRegex = unittest.TestCase.assertRaisesRegexp
+
+
+class TestOptimise(unittest.TestCase):
+    """
+    Tests the pkpd.optimise function.
+    """
+
+    @classmethod
+    def setUpClass(cls):
+        # Define objective function
+        model = pints.toy.ConstantModel(1)
+        times = np.linspace(1, 10)
+        cls.true_params = [2.5]
+        values = model.simulate(cls.true_params, times)
+        problem = pints.SingleOutputProblem(model, times, values)
+        cls.error = pints.SumOfSquaresError(problem)
+
+        # Define initial parameters
+        cls.params = [[3]]
+
+        # Define boundaries
+        cls.boundaries = pints.RectangularBoundaries(1, 5)
+
+    def test_bad_objective_function(self):
+        objective_function = 'bad obj func'
+
+        self.assertRaisesRegex(
+            ValueError, 'Objective function has to be',
+            pkpd.optimise, objective_function, pints.CMAES, self.params)
+
+    def test_bad_optimiser(self):
+        optimiser = pints.LogPDF
+
+        self.assertRaisesRegex(
+            ValueError, 'Optimiser has to be',
+            pkpd.optimise, self.error, optimiser, self.params)
+
+    def test_bad_parameters(self):
+        params = [[1, 2, 3]]
+
+        self.assertRaisesRegex(
+            ValueError, 'Initial parameters has the wrong shape!',
+            pkpd.optimise, self.error, pints.CMAES, params)
+
+    def test_bad_boundaries(self):
+        boundaries = 'boundaries'
+
+        self.assertRaisesRegex(
+            ValueError, 'Boundaries have to be',
+            pkpd.optimise, self.error, pints.CMAES, self.params, 1, boundaries)
+
+    def test_nan_when_fails(self):
+        # CMAES return NAN for 1-dim problems
+        params, _ = pkpd.optimise(
+            self.error, pints.CMAES, self.params, 1, self.boundaries)
+
+        self.assertEqual(params.shape, (1, 1))
+        np.testing.assert_equal(params[0, 0], np.nan)
+
+    def test_call(self):
+        # Test single run
+        params, _ = pkpd.optimise(
+            self.error, pints.XNES, self.params, 1, self.boundaries)
+
+        self.assertEqual(params.shape, (1, 1))
+        self.assertAlmostEqual(params[0, 0], self.true_params[0], 1)
+
+        # Test multiple runs
+        initial_params = [[2], [3]]
+        params, _ = pkpd.optimise(
+            self.error, pints.XNES, initial_params, 2, self.boundaries)
+
+        self.assertEqual(params.shape, (2, 1))
+        self.assertAlmostEqual(params[0, 0], self.true_params[0], 1)
+        self.assertAlmostEqual(params[1, 0], self.true_params[0], 1)
+
+
+if __name__ == '__main__':
+    unittest.main()