tokens: Among 117 Japanese hyperalphalipoproteinemic subjects ( HDL - cholesterol ; 116 . 7 + / - 16 . 5 mg / dl , mean + / - S . D . ) without the intron 14 splice defect , three homozygotes ( 2 . 5 % ) and 34 heterozygotes ( 29 . 1 % ) were found to have the 442D G mutation .