Sr Bioinformatics Scientist at Invitae

Invitae is a biotechnology company focused on providing tools and services for clinical research applications of genomics. Our mission is to unlock the power of precision medicine in improving patient care by providing a technology platform to advance genomics and facilitate collaborative research.
 Invitae is seeking Bioinformaticians to join our team. This role will be centered around creating workflows, tools and algorithms to complement assay/product development. The ideal candidate should be able to perceive a problem clearly and dissect it into components which can be resolved programmatically. Having a comprehensive grasp of genomics and next generation sequencing will be key to succeeding in this role. The candidate should be independent, well organized and collaborative with clear communication skills. In addition, the ability to frequently switch between tasks will be helpful. 
As necessary, but not as a primary role, the candidate will assist the Clinical team in ad-hoc analysis and research required to meet regulatory requirements. You will be responsible for scaling our pipelines as we work toward our goal of providing low-cost genetic answers to billions of people.
  Responsibilities:

Develop high-performance bioinformatics workflows that can accurately and reliably analyze large volumes of NGS data using Nextflow in a system agnostic manner
Collaborate in a cross-disciplinary team by building, deploying, and maintaining software solutions compatible with distributed and/or containerized systems
Designing APIs using industry best practices to streamline communication between various Invitae platforms
Develop best practices for analysis of NGS data including optimization of parameters, resource utilization, and consensus approaches across various NGS applications
Mentor budding engineers/scientists by participating in code review/analysis sessions
Drive genetics technology development in a cross-disciplinary setting by critically analyzing and deriving insights from experimental data (including NGS, arrays, and novel technologies) using open source NGS tools and building custom tools when needed
Develop reproducible analysis for research and development purposes
Review, understand, and stay in compliance with Invitae HIPAA Security policies and procedures
Optionally, build and evaluate algorithms and statistical models to improve existing genetics applications within and beyond NGS technologies and create novel ones
Optionally, maintain a visible profile in the Bioinformatics community through publications, conference presentations, and collaborations

Good to Have Qualifications: 

MS with 8+ years experience or PhD with 5+ years experience in Bioinformatics or Computational Biology
Fluent in R/Python
Fluent in *nix, and SQL like DB technology for data analysis
Working knowledge of standard bioinformatic tools used in NGS pipelines
Working knowledge of pipeline workflow engines: Nextflow, Snakemake
Strong knowledge of Genomics and Molecular Biology
Solid understanding of Illumina sequencing technologies and metrics
Formal statistics background is a plus
Formal software development experience (preferred)
Understanding of Cloud Computing (preferred)

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