natgillin/translations-raw huggingface dataset:
In a young adult cattle study, gamithromycin was administered by subcutaneous injection at 6, 18, and 30 mg/ kg (1, 3, and 5 times the recommended dose) and repeated three times at 0, 5 and 10 days (three times the recommended duration of use).
V študiji na mladem odraslem govedu so subkutano injicirali 6, 18 in 30 mg/ kg (1, 3 in 5- kraten priporočen odmerek zdravila) in dajanje ponovili trikrat pri 0, 5 in 10 dneh (tri- kratno priporočeno trajanje zdravljenja).
64 days
64 dni
QJ01FA95
Makrolidi, oznaka ATC vet QJ01FA95
Gamithromycin is an azalide, 15-membered semisynthetic macrolide class antibiotic with uniquely positioned alkylated nitrogen at 7a-position of the lactone ring.
Gamitromicin je azalid, antibiotik iz razreda 15- tih polsintetičnih makrolidnih antibiotikov z edinstvenim 7a položajem alkiliziranega dušika na laktonskem obroču.
This special chemistry facilitates rapid absorption at physiological pH and a long duration of action at the target tissue, lung.
Ta kemijska posebnost omogoča izjemno hitro absorbcijo pri fiziološkem pH in dolgotrajno učinkovanje v ciljnem tkivu, pljučih.
The broad spectrum antimicrobial activity of gamithromycin includes Mannheimia haemolytica, Pasteurella multocida and Histophilus somni, the bacterial pathogens most commonly associated with BRD.
Širok spekter delovanja gamitromicina vključuje Manheimia haemolytica, Pasteurella multocida in Histophilus somni, bakterijske povzročitelje, ki so najpogosteje povezani z BRD.
The MIC and MBC data are reported from a representative sample of isolates from field materials within different geographic EU areas.
MIK in MBK podatki so pridobljeni iz reprezentativnih vzorcev izolatov s terena iz različnih geografskih področij EU.
0.5 1 1
0. 5
1 2 2
2
Three mechanisms are generally considered responsible for resistance to the macrolide class of compounds.
To je t. i.
This is often referred to as MLSB resistance as it affects macrolides, lincosamides and streptogramins.
MLSB rezistenca, ker zajema makrolide, linkozamide in streptogramine.
Gamithromycin administered subcutaneously into the neck of cattle at single dosage of 6 mg/ kg body weight, resulted in rapid absorption with peak plasma concentrations observed after 30 to 60 min with a long plasma half-life (> 2 days).
Subkutana aplikacija gamitromicina v predel vratu pri govedu v enkratnem odmerku 6mg/ kg telesne teže je absorbcija učinkovine izjemno hitra, z viškom koncentracije v plazmi po 30 do 60 minutah in z dolgo biološko razpolovno dobo (> 2 dni).
The bioavailability of the drug was > 98% with no gender differences.
Biorazpoložljivost zdravila je > 98%, brez razlik med spoloma.
The volume of distribution at steady-state was 25 l/ kg.
Volumen distribucije pri ustaljenem stanju je 25 l/ kg.
Gamithromycin levels in lung reached a maximum in less than 24 hr, with lung-to-plasma ratio of > 264 indicating that the drug was absorbed rapidly into the target tissue for BRD.
Višek koncentracije gamitromicina v pljučih je v manj kot 24 urah, z razmerjem pljuča – plazma > 264, kar kaže na izjemno hitro absorbcijo v tarčno tkivo za BRD.
In vitro plasma protein binding studies determined that the mean concentration of the free drug was 74%.
In vitro študije vezanja plazemskih proteinov kažejo, da je povprečna koncentracija prostega zdravila 74%.
6.3 Shelf life
4/ 17 6. 3 Rok uporabnosti
4/ 17 Shelf life after first opening the immediate packaging:
Rok uporabnosti po prvem odpiranju stične ovojnine:
Type 1 glass vial with a chlorobutyl rubber stopper and an aluminum cap.
Steklena viala (steklo tip 1) s klorobutilno gumijasto zaporko in aluminijevim pokrovčkom.
Box containing 1 vial of 100, 250 or 500 ml Not all pack sizes may be marketed.
Ni nujno, da so v prometu vsa navedena pakiranja.
MERIAL 29 avenue Tony Garnier F - 69007 Lyon France
MERIAL 29 avenue Tony Garnier F - 69007 Lyon Francija
MERIAL 4, Chemin du Calquet 31057 Toulouse Cedex France
MERIAL 4, Chemin du Calquet 31057 Toulouse Cedex Francija
Gamithromycin is included in Annex III of Council Regulation (EEC) No 2377/ 90 in accordance with the following table:
Gamitromicin je vključen v Dodatek III Uredbe Sveta (ES) No 2377/ 90 kot je navedeno v tabeli:
Pharmacologically Marker residue active substance
Marker zaostanek
Gamithromycin Gamithromycin
Gamitromicin Gamitromicin
Fat Liver Kidney
potečejo 1. 7. 2009
Provisional MRLs expire on 1.7.2009 Not for use in animals producing milk for human consumption
Ne uporabite pri živalih v laktaciji, katerih mleko je namenjeno prehrani ljudi.
Annex II of Council Regulation (EEC) No 2377/ 90:
Dodatek II Uredbe Sveta (ES) No 2377/ 90:
Pharmacologically active substance(s) Monothioglycerol 1 Succinic Acid (E 363) 2 Glycerol Formal 3
Farmakološko aktivna snov
Animal species All food animal species All food animal species All food animal species
Marker zaostanek
1 OJ No.
Monotioglicerol 1 Sukcinilna kislina (E363) 2 Glicerol formal 3 1 OJ No.
9/ 17 PARTICULARS TO APPEAR ON THE OUTER PACKAGE AND ON THE IMMEDIATE PACKAGE (except 100 ml trilingual)
PRIMARNI OVOJNINI (razen 100 ml tri jezične ovojnine)
{BOX and VIAL}
{ŠKATLICA in VIALA}
ZACTRAN 150 mg/ ml solution for injection for cattle Gamithromycin
ZACTRAN 150 mg/ ml raztopina za injiciranje za govedo Gamitromicin
1 ml contains 150 mg of gamithromycin 1 mg of monothioglycerol
1 ml raztopine vsebuje 150 ml gamitromicina 1 mg monotioglicerola
Single subcutaneous injection of 6 mg gamithromycin/ kg body weight (equivalent to 1 ml/ 25 kg body weight).
Subkutano injiciranje enkratnega odmerka 6 mg gamitromicina/ kg telesne teže (kar ustreza 1ml/ 25 kg telesne teže).
Withdrawal period Meat and offal:
Meso in organi:
64 days Not permitted for use in lactating animals producing milk for human consumption.
64 dni Ni dovoljena uporaba pri živalih v laktaciji, katerih mleko je namenjeno prehrani ljudi.
People with known hypersensitivity to the macrolide class should avoid contact with the product.
Osebe z znano preobčutljivostjo na makrolidne antibiotike naj se izogibajo stiku z zdravilom.
EXP Once opened, use within 28 days.
EXP Odprto zdravilo uporabite v 28 dneh.
Dispose of waste material in accordance with local requirements.
Neporabljeno zdravilo ali odpadne snovi je treba odstraniti v skladu z lokalnimi predpisi.
12/ 17 PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGE
12/ 17 PODATKI NA STIČNI OVOJNINI
{VIAL}
{VIALA}
Withdrawal period.
Karenca:
ZACTRAN 150mg/ ml solution for injection for cattle
14/ 17 NAVODILO ZA UPORABO ZACTRAN 150 mg/ ml raztopina za injiciranje za govedo
MERIAL 4, Chemin du Calquet F - 31057 Toulouse Cedex France
MERIAL 4, Chemin du Calquet F - 31057 Toulouse Cedex Francija
ZACTRAN 150mg/ ml solution for injection for cattle Gamithromycin
ZACTRAN 150 mg/ ml raztopina za injiciranje za govedo Gamitromicin
STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENT
NAVEDBA ZDRAVILNEUČINKOVINE IN DRUGEIH SESTAVIN
1 ml contains 150 mg of gamithromycin 1 mg of monothioglycerol
1 ml raztopine vsebuje 150 mg gamitromicina 1 mg monotioglicerola
Do not use this product simultaneously with other macrolides or antibiotics known as lincosamides.
Ne uporabite tega zdravila sočasno z drugimi makrolidnimi antibiotiki ali antibiotiki, ki jim pravimo linkozamidi.
Transient injection site swellings with occasional slight pain.
Prehodna oteklina na mestu dajanja z občasno blažjo bolečino.
If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinarian.
Če opazite kakršne koli resne neželene učinke ali druge učinke, ki niso omenjeni v teh navodilih za uporabo, obvestite svojega veterinarja.
To ensure correct dosage body weight should be determined as accurately as possible to avoid underdosing.
Da ne pride do premajhnega odmerjanja je potrebna kar se da natančna ocena telesne teže.
Do not use in pregnant cows or heifers, which are intended to produce milk for human consumption, within 2 months of expected parturition
Ne uporabite pri brejih živalih, katerih mleko je namenjeno prehrani ljudi, v obdobju 2 mesecev pred pričakovanim porodom.
Do not use after the expiry date which is stated on the vial.
Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na viali.
Use according to the benefit/ risk assessment by the responsible veterinarian.
Uporabite le v skladu z oceno tveganja pristojnega veterinarja.
Box containing 1 vial of 100, 250 or 500 ml.
Škatlica z eno 100 ml, 250 ml ali 500 ml vialo.
EMEA/ CVMP/ 221/ 01
EMEA/ CVMP/ 140415/ 2006
Zubrin is an oral lyophilisate, i. e. a kind of tablet that will quickly disintegrate upon contact with moisture e. g. when placed on your dog’ s tongue.
Zdravilo Zubrin je oralni liofilizat, t. j. vrsta tablet, ki se hitro razgradijo ob stiku z vlago, npr. ko tableto položite na jezik psa.
Zubrin is given to the dog once a day within 1-2 hours after feeding until the dog gets better.
Zdravilo Zubrin se daje psom enkrat dnevno 1- 2 uri po hranjenju, dokler se stanje ne izboljša.
Zubrin acts by blocking enzymes, cyclooxygenase-1 and cyclooxygenase-2.
Zdravilo Zubrin deluje z zaviranjem encimov ciklooksigenaza- 1 in ciklooksigenaza- 2.
As the prostaglandins are substances that trigger inflammation, tepoxalin reduces the inflammation and the swelling of muscles or joints and the pain associated with this.
Ker prostaglandini sprožajo vnetje, tepoksalin zmanjša vnetje in otekanje mišic ali sklepov ter bolečine, ki so povezane s tem procesom.
(44-20) 74 18 84 00 Fax (44-20) 74 18 84 47 E-mail: mail@emea. eu. int http: / /www. emea. eu. int ©EMEA 2006 Reproduction and/ or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged How has the effectiveness of Zubrin been studied?
(44- 20) 74 18 84 00 Fax (44- 20) 74 18 84 47 E- mail: mail@ emea. eu. int http: // www. emea. eu. int ©EMEA 2006 Reproduction and/ or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged Kako je bilo zdravilo Zubrin raziskano?
Zubrin has been studied in laboratory animals, as well as in dogs that were treated in various veterinary practices/ clinics in the USA and in a number of countries in Europe (“ clinical studies”).
Zdravilo Zubrin je bilo preučeno na laboratorijskih živalih in na psih, ki so bili zdravljeni v različnih veterinarskih ambulantah/ klinikah v ZDA in številnih državah v Evropi („ klinične raziskave “).
In these clinical studies, the animal owners gave Zubrin to their dogs, once daily at a dose of 10 mg per kg dog’ s bodyweight with or without food.
V teh kliničnih raziskavah so lastniki živali dajali Zubrin psom enkrat dnevno v odmerku 10 mg na kg telesne mase psa z ali brez hrane.
The best results were achieved when Zubrin was adminstered 1-2 hours after feeding.
Najboljše rezultate so dosegli z dajanjem zdravila Zubrin 1- 2 uri po hranjenju.
The animals were treated until they got better; however, since side effects might occur, any treatment exceeding 1 – 2 weeks should be under regular veterinary supervision.
Ker pa se lahko pojavijo neželeni učinki, mora biti vsako zdravljenje, ki je daljše od 1 do 2 tednov, pod rednim veterinarskim nadzorom.
Also, before you start using Zubrin, inform the veterinarian if your dog receives any other medication since some medicines might influence each other’ s effectiveness.
Ravno tako je treba pred začetkom uporabe zdravila Zubrin veterinarja obvestiti, če pes prejema katerakoli druga zdravila, saj lahko nekatera zdravila vplivajo na učinkovitost drugih zdravil.
Zubrin should be placed directly into the dog’ s mouth and you should try to keep the mouth of the dog closed for a short while.
Zdravilo Zubrin morate položiti neposredno v gobec psa, nato pa poskusite gobec psa za kratek čas zadržati zaprtega.
The European Commission granted a marketing authorisation valid throughout the European Union, for Zubrin to S-P Veterinary on 13 March 2001.
Evropska Komisija je dovoljenje za promet z zdravilom Zubrin, veljavno po vsej Evropski uniji, odobrila družbi S- P Veterinary dne 13. marca 2001.
This summary was last updated in March 2006.
Ta povzetek je bil nazadnje posodobljen marca 2006.
Blister (alu/ alu)
Pretisni omot (Alu/ Alu)
Zubrin 50 mg oral lyophilisates for dogs Zubrin 100 mg oral lyophilisates for dogs Zubrin 200 mg oral lyophilisates for dogs
Zubrin 50 mg oralni liofilizat za pse Zubrin 100 mg oralni liofilizat za pse Zubrin 200 mg oralni liofilizat za pse
50 mg / oral lyophilisate
Zdravilna učinkovina
Tepoxalin Tepoxalin
Tepoksalin Tepoksalin Tepoksalin
100 mg / oral lyophilisate 200 mg / oral lyophilisate
50 mg / oralni liofilizat 100 mg / oralni liofilizat 200 mg / oralni liofilizat
For a full list of excipients, see
Celoten seznam pomožnih snovi, glej razdelek 6. 1.
Oral lyophilisates
Oralni liofilizat
2 Special precautions to be taken by the person administering the medicinal product to animals
2 Posebni previdnostni ukrepi, ki jih mora izvajati oseba, ki živalim daje zdravilo
If the oral lyophilisate disintegrates prematurely, wash hands thoroughly.
Če se oralni liofilizat prehitro razgradi, dobro umijte roke.
In case of ingestion of a number of oral lyophilisates by a person, the advice of a doctor should be sought immediately.
V primeru, da neka oseba zaužije številne oralne liofilizate, se takoj posvetujte z zdravnikom.
If there are such undesirable effects, treatment should be discontinued immediately.
Značilni stranski učinki uporabe nesteroidnih protivnetnih zdravil (NSPVZ) so bruhanje, mehko blato/ driska, kri v blatu, zmanjšan apetit in letargija Če se neželeni učinki pojavijo, je potrebno zdravljenje takoj prenehati.
During clinical trial testing of the product, the incidence of gastrointestinal reactions (diarrhoea/ vomiting) was 10%.
V času kliničnega preiskušanja proizvoda je bila pojavnost želodčno črevesnih reakcij (driska/ bruhanje) 10%.
Long term treatment should be under regular veterinary supervision.
Po 7- 10 dnevnem zdravljenju se psa ponovno pregleda, da se ugotovi ali je potrebno nadaljevati z zdravljenjem.
The weight of the animal should be accurately determined before start of treatment.
Dolgotrajno zdravljenje naj bo pod rednim veterinarskim nadzorom. Teža živali mora biti natančno določena pred pričetkom zdravljenja.
Peel back foil to reveal a single oral lyophilisate in the form of a round tablet.
Za odprtje posameznega oralnega liofilizata, ki je v obliki okrogle tablete, odlepi folijo na zadnji strani.
Place the tablet in the dog’ s mouth.
Pritisni dno pretisnega omota in tableta se prikaže.
The tablet will disintegrate upon contact with moisture.
Daj tableto živali v gobec.
Keep the mouth of the dog closed for a few seconds to ensure complete tablet wetting.
Tableta se bo v stiku z vlago razgradila.
Administer to dogs within 1-2 hours after feeding.
Držite gobec psa zaprt še nekaj sekund, zato da se tableta v celoti navlaži.
When this is not possible, or when dogs resist having the product placed directly into the mouth, put the tablet immediately before administration into a small amount of moistened food, or in a moist treat.
Zdravilo dajte psom 1- 2 uri po hranjenju. V kolikor to ni mogoče ali ko zdravila ne morete dati psom neposredno v gobec, vstavite tableto neposredno pred dajanjem v manjšo količino navlažene hrane ali v navlažen obrok.
At doses of 30 mg/ kg and above, oral administration of tepoxalin is associated with discoloured faeces ranging in colour from white to yellow, which is the result of unabsorbed drug.
Po peroralnih vnosih odmerkov 30 mg tepoksalina na kg telesne mase in več se pojavlja razbarvanje blata.
NSAID overdosage is characterised by vomiting, soft faeces/ diarrhoea, blood in faeces, reduced appetite and lethargy.
Barva blata je lahko bela do rumena, kar je posledica neabsorbiranega zdravila.
In the case of overdosage discontinue therapy.
Preveliko odmerjanje NSPVZ se kaže z bruhanjem, mehkim blatom/ drisko, pojavom krvi v blatu, zmanjšanim apetitom in letargijo.
If gastrointestinal bleeding is suspected, administer gastric protectants.
V primeru prevelikega odmerjanja prenehajte z zdravljenjem. Če posumite na krvavitve v želodcu ali črevesju, uporabite zdravila za zaščito želodca.
Anti-inflammatory Products, Non Steroids ATCvet code:
Farmakoterapevtska skupina: nesteroidno protivnetno zdravilo Oznaka ATCvet:
Tepoxalin is a dual cyclooxygenase / 5-lipoxygenase inhibitor with anti-inflammatory activity.
Tepoksalin je dvojni zaviralec ciklooksigenaze / 5- lipoksigenaze s protivnetnim delovanjem.
Oral administration of 10 mg tepoxalin / kg bodyweight results in inhibition of prostaglandin and leukotriene synthesis.
Po peroralnem vnosu 10 mg tepoksalina/ kg telesne mase pride do zaviranja sinteze prostaglandinov in leukotrienov.
Tepoxalin is rapidly (Tmax of approximately 2 hours) absorbed after oral administration in dogs.
5. 2 Farmakokinetične posebnosti
At a therapeutic dose of 10 mg/ kg, the Cmax of tepoxalin was 1.08 ± 0.37 µg/ ml in dogs fed a low fat meal and 1.19 ± 0.29 µg/ ml in dogs fed a high fat meal.
Pri uporabi zdravilnega odmerka 10 mg/ kg pri psih, ki so bili hranjeni z obroki z nizko vsebnostjo maščob, je bila Cmax tepoksalina 1. 08 ± 0. 37 µg/ ml.
Zubrin oral lyophilisates are supplied in boxes with foil blisters.
Zubrin oralni liofilizati se dobavljajo v škatlah z pretisnimi omoti.
Each blister contains 10 oral lyophilisates.
Vsak pretisni omot vsebuje 10 oralnih liofilizatov.
The oral lyophilisates are available in the following pack sizes:
Oralni liofilizati se nahajajo v naslednjih velikostih pakiranj:
200 mg:
50 mg, 100 mg 200 mg
4 6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
4 6. 6 Posebni varnostni ukrepi za odstranjevanje neporabljenega zdravila ali odpadnih snovi, če obstajajo
S-P Veterinary Shire Park Welwyn Garden City Hertfordshire AL7 1TW United Kingdom
S- P Veterinary Shire Park Welwyn Garden City Hertfordshire AL7 1TW Velika Britanija
S-P Veterinary Ltd Breakspear Road South Harefield Uxbridge UB9 6LS United Kingdom
S- P Veterinary Ltd Breakspear Road South Harefield Uxbridge UB9 6LS Velika Britanija
{50 mg oral lyophilisate}
{50 mg oralni liofilizat}
Zubrin 50 mg oral lyophilisates for dogs
Zubrin 50 mg oralni liofilizat za pse
50 mg / oral lyophilisate
50 mg / oralni liofilizat
Oral lyophilisates
Oralni liofilizati
10 mg/ kg of body weight once daily.
10 mg/ kg telesne mase enkrat dnevno.
After a treatment period of 7-10 days, the condition of the dog should be re-evaluated in order to establish the need for continuation of treatment.
Po 7- 10 dnevnem zdravljenju se psa ponovno pregleda, da se ugotovi ali je potrebno nadaljevati z zdravljenjem.
When this is not possible, or when dogs resist having the product placed directly into the mouth, put the tablet immediately before administration into a small amount of moistened food, or in a moist treat.
Zdravilo dajte psom 1 - 2 uri po hranjenju. V kolikor to ni mogoče ali ko zdravila ne morete dati psom neposredno v gobec, vstavite tableto neposredno pred dajanjem v manjšo količino navlažene hrane ali v navlažen obrok.
Ensure hands are dry to prevent the oral lyophilisate from sticking to fingers
Zato da preprečite lepljenja oralnega liofilizata na prste, imejte suhe roke.
EU/ 2/ 00/ 028/ 002 (1 blister) EU/ 2/ 00/ 028/ 003 (3 blisters)
EU/ 2/ 00/ 028/ 002 (1 pretisni omot) EU/ 2/ 00/ 028/ 003 (3 pretisni omoti)
{100 mg oral lyophilisate}
{100 mg oralni liofilizat}
Zubrin 100 mg oral lyophilisates for dogs
Zubrin 100 mg oralni liofilizat za pse
100 mg / oral lyophilisate
100 mg / oralni liofilizat
EU/ 2/ 00/ 028/ 004 (1 blister) EU/ 2/ 00/ 028/ 005 (3 blisters)
EU/ 2/ 00/ 028/ 004 (1 pretisni omot) EU/ 2/ 00/ 028/ 005 (3 pretisni omoti)
{200 mg oral lyophilisate}
{200 mg oralni liofilizat}
Zubrin 200 mg oral lyophilisates for dogs
Zubrin 200 mg oralni liofilizat za pse
200 mg / oral lyophilisate
200 mg / oralni liofilizat
EU/ 2/ 00/ 028/ 006 (1 blister) EU/ 2/ 00/ 028/ 007 (3 blisters) EU/ 2/ 00/ 028/ 008 (6 blisters)
EU/ 2/ 00/ 028/ 006 (1 pretisni omot) EU/ 2/ 00/ 028/ 007 (3 pretisni omoti) EU/ 2/ 00/ 028/ 008 (6 pretisnih omotov)
15 MINIMUM PARTICULARS TO APPEAR ON BLISTER
15 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
Zubrin 50 mg oral lyophilisates for dogs Zubrin 100 mg oral lyophilisates for dogs Zubrin 200 mg oral lyophilisates for dogs Tepoxalin
Zubrin 50 mg oralni liofilizat za pse Zubrin 100 mg oralni liofilizat za pse Zubrin 200 mg oralni liofilizat za pse Tepoksalin
Zubrin oral lyophilisates for dogs
Zubrin oralni liofilizat za pse
Do not use if your dog • is pregnant or lactating or in bitches intended for breeding • has cardiac or hepatic disease • has had gastrointestinal ulceration or bleeding • is hypersensitive to the product • is dehydrated, hypovolaemic or hypotensive, as there is an increased risk of renal toxicity.
Ne uporabljajte pri živalih: • v času brejosti in laktacije, ter pri psicah, ki so namenjene za razplod • z boleznimi srca ali jeter • z želodčnimi ali črevesnimi razjedami ali s krvavitvijo • ki so preobčutljive na zdravilo • ki so dehidrirane, hipovolemične ali hipotenzivne, ker obstaja povečana nevarnost toksičnega učinka na ledvice.
During clinical trial testing of the product, the incidence of gastrointestinal reactions (diarrhoea/ vomiting) occurred in 1 out of 10 animals.
V času kliničnega preiskušanja proizvodaso se želodčno črevesne reakcije (driska/ bruhanje) pojavile pri 1 od 10 živali.
10 mg/ kg once daily.
10 mg/ kg enkrat dnevno.
The weight of the animal should be accurately determined before start of treatment.
Težo živali je potrebno natančno določiti pred pričetkom zdravljenja, Za odprtje posameznega oralnega liofilizata, ki je v obliki okrogle tablete, odlepi folijo na zadnji strani.
Peel back foil to reveal a single oral lyophilisate in the form of a round tablet.
Roke morajo biti suhe, zato da preprečimo morebitno lepljenje na prste.
19 If side effects occur, treatment should be discontinued and the advice of a veterinary surgeon should be sought.
19 Posebni previdnostni ukrepi so potrebni pri uporabi zdravila pri psih z okvaro ledvic.
In case of ingestion of a number of oral lyophilisates by a person, the advice of a doctor should be sought immediately.
V primeru pojava stranskih učinkov prenehajte z zdravljenjem in se posvetujte z veterinarjem.