natgillin/translations-raw huggingface dataset:
EU/ 2/ 06/ 066/ 004 (3 pipettes) EU/ 2/ 06/ 066/ 005 (6 pipettes) EU/ 2/ 06/ 066/ 006 (30 pipettes)
EU/ 2/ 06/ 066/ 004 (3 merilne kapalke) EU/ 2/ 06/ 066/ 005 (6 merilne kapalke) EU/ 2/ 06/ 066/ 006 (30 merilne kapalke)
19 MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS Blister (137.5 mg)
19 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA MANJŠIH STIČNIH OVOJNINAH
20 MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS Pipette (137.5 mg)
20 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
Prac-tic 137.5 mg
Prac- tic 137, 5 mg piriprol
(275 mg)
Zloženka (275 mg)
Prac-tic 275 mg Spot-on solution for medium dogs
Prac- tic 275 mg kožni nanos,, raztopina za srednje velike pse
Unit dose 2.2 ml
odmerek 2, 2 ml
Pyriprole 275 mg
piriprol 275 mg
Dogs (> 11-22 kg)
psi (> 11 – 22 kg)
EU/ 2/ 06/ 066/ 007 (3 pipettes) EU/ 2/ 06/ 066/ 008 (6 pipettes) EU/ 2/ 06/ 066/ 009 (30 pipettes)
EU/ 2/ 06/ 066/ 007 (3 merilne kapalke) EU/ 2/ 06/ 066/ 008 (6 merilne kapalke) EU/ 2/ 06/ 066/ 009 (30 merilne kapalke)
24 MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS Blister (275 mg)
Pretisni omot (275 mg)
Pipette (275 mg)
Merilna kapalka (275 mg)
Prac-tic 275 mg
Prac- tic 275 mg piriprol
LOT {number}
Serija
Cardboard Carton (625 mg)
Zloženka (625 mg)
Prac-tic 625 mg Spot-on solution for large dogs
Prac- tic 625 mg kožni nanos,, raztopina za velike pse
Unit dose 5.0 ml
odmerek 5, 0 ml
Pyriprole 625 mg
piriprol 625 mg
Dogs (> 22-50 kg)
psi (> 22- 50 kg)
2.
Nanos na kožo 1. Iz embalaže vzemite merilno kapalko 2.
Place the tip of the pipette on the skin and squeeze the pipette gently several times at 2-3 spots down the back-line of large dogs to prevent runoff.
Postavite konico merilne kapalke na kožo in večkrat narahlo stisnite na enem ali dveh mestih, da iztisnete vsebino na kožo.
MARKETING AUTHORISATION NUMBER(S)
ŠTEVILKA( E DOVOLJENJ( A) ZA PROMET
EU/ 2/ 06/ 066/ 010 (3 pipettes) EU/ 2/ 06/ 066/ 011 (6 pipettes) EU/ 2/ 06/ 066/ 012 (30 pipettes)
EU/ 2/ 06/ 066/ 010 (3 merilne kapalke) EU/ 2/ 06/ 066/ 011 (6 merilne kapalke) EU/ 2/ 06/ 066/ 012 (30 merilne kapalke)
Blister (625 mg)
Pretisni omot (625 mg)
Pipette (625 mg)
Merilna kapalka (625 mg)
Prac-tic 625 mg
Prac- tic 625 mg piriprol
Prac-tic spot-on solution for dogs
Prac- tic kožni nanos,, raztopina za pse
Read this leaflet before use and administer the veterinary medicinal product with caution.
Pred uporabo preberite navodilo in uporabljajte zdravilo previdno
Novartis Sanidad Animal S. L.
Imetnik dovoljenja za promet z zdravilom Novartis Sanidad Animal S. L.
Novartis Santé Animale S. A. S Usine de Huningue 26, rue de la Chapelle F-68332 Huningue Cedex France
Novartis Sante Animale S. A. S Usine de Huningue 26, rue de la Chapelle F- 68330 Huningue Cedex Francija
Prac-tic 56.25 mg Spot-on solution for very small dogs Prac-tic 137.5 mg Spot-on solution for small dogs Prac-tic 275 mg Spot-on solution for medium dogs Prac-tic 625 mg Spot-on solution for large dogs
Prac- tic 56, 25 mg kožni nanos,, raztopina za zelo majhne pse Prac- tic 137, 5 mg kožni nanos,, raztopina za majhne pse Prac- tic 275 mg kožni nanos,, raztopina za srednje velike pse Prac- tic 625 mg kožni nanos,, raztopina za velike pse
Each ml contains 125 mg pyriprole as a colourless to yellow, clear solution.
1 ml vsebuje 125 mg piriprola v brezbarvni do rumeni bistri raztopini.
The solution also contains 0.1% Butylhydroxytoluene (E321)
Raztopina vsebuje tudi 0, 1% butilhidroksitoluena (E321)
Treatment and prevention of flea infestation (Ctenocephalides canis and C. felis.).
Zdravljenje in preprečevanje infestacij z bolhami (Ctenocephalides spp.).
Prac-tic is effective against new infestations with fleas for a minimum duration of 4 weeks.
Prac- tic je učinkovit proti novim infestacijam z bolhami; učinek traja najmanj 4 tedne.
The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).
Izdelek se lahko uporablja kot del strategije zdravljenja za obvladovanje alergijskega dermatitisa, ki ga povzročijo bolhe (FAD).
Treatment and prevention of tick infestation (Ixodes ricinus, Ixodes scapularis, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus, Amblyomma americanum).
Zdravljenje in preprečevanje infestacij s klopi (Ixodes ricinus, Ixodes hexagonus, Ixodes scapularis, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus, Amblyomma americanum).
Prac-tic has a persistent effect for 4 weeks against ticks.
Učinek Prac- tica proti klopom traja 4 tedne.
Do not use in dogs less than 8 weeks of age or weighing less than 2 kg.
Zdravilo se ne sme uporabljati pri psih, mlajših od 8 tednov ali psih, ki tehtajo manj kot 2 kg.
Do not use in case of known hypersensitivity to phenylpyrazole class compounds or to any of the excipients.
Prav tako se zdravilo ne sme uporabljati v primeru znane preobčutljivosti na snovi iz skupine fenilpirazolov ali na katero koli pomožno snov.
Do not use in sick or convalescent animals.
Zdravila ne uporabljajte pri bolnih ali okrevajočih živalih.
This product is specifically developed for dogs.
Zdravilo se uporablja izključno samo pri psih.
However, those signs disappear within 24 hours of the application.
Lokalni učinki kozmetične narave na mestu nanosa kot so masten izgled ali grudice na dlakah so običajne, izginejo pa v 24 urah po nanosu.
For spot-on use.
Nanos na kožo
The recommended minimum dose is 12.5 mg/ kg bodyweight pyriprole, equivalent to 0.1 ml/ kg bodyweight of the veterinary medicinal product.
Najmanjši priporočeni odmerek je 12, 5 mg piriprola/ kg telesne mase, kar je enako 0, 1 ml Prac- tic raztopine/ kg telesne mase.
Within each weight band the entire contents of the correct size pipette should be used.
V okviru posameznega težnostnega razreda uporabite celotno vsebino ustrezne merilne kapalke
Pipette size to be
Merilna kapalka
Volume of 12.5%
volumen 12. 5%
(w/ v) solution (ml)
(t/ v) raztopine (ml)
(mg / kg bw)
(mg/ kg tel. mase)
Very small dog
za zelo majhne pse
Small dog Medium dog Large dog
za majhne pse za srednje velike pse za velike pse primerna kombinacija merilnih kapalk
34 Flea treatment and prevention
34
One treatment prevents future flea infestation for 4 weeks.
Eno zdravljenje prepreči infestacijo z bolhami za 4 tedne.
One treatment has efficacy duration of 4 weeks.
Učinek enega zdravljenja traja 4 tedne.
For external use only.
Samo za zunanjo uporabo
Then hold it in an upright position.
Iz embalaže vzemite merilno kapalko, postavite jo pokonci.
Tap the narrow part of the pipette to ensure the contents remain within the widest part.
Rahlo potolcite ožji del, da ostane vsebina v glavnem delu.
Apply the 5 ml pipette to 2-3 spots down the backline of large dogs so as to prevent run-off.
Nanesite vsebino 5- ml merilne kapalke na 2- 3 mestih vzdolž vratnega dela hrbtenice velikih psov na tak način, da preprečite odtekanje tekočine.
However, should this happen it will disappear within 24 hours.
Pazite, da dlak na mestu nanosa ne omočite preveč, sicer se dlake na mestu nanosa lahko zlepijo, kar pa izgine v 2 dneh po nanosu zdravila.
In cases of heavy infestation with fleas prior to treatment, the dog’ s surrounding should be vacuumed and treated with a suitable insecticide.
V primeru večjega napada bolh je potrebno pred zdravljenjem mesto okrog psa posesati in uporabiti primeren insekticid.
Do not use after the expiry date stated on the pipette after “ EXP”.
Shranjujte nedosegljivo otrokom Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na merilni kapalki.
People with known allergies to the phenylpyrazole class of compounds or either of the excipients should avoid contact with the veterinary medicinal product.
Osebe z znano preobčutljivostjo za spojine iz skupine fenilpirazolov ali za katerokoli od pomožnih snovi naj se izogibajo stiku z zdravilom.
If the veterinary medicinal product accidentally gets in your eyes, rinse them carefully with water.
Če zdravilo nehote zaide v oči, je treba oči skrbno sprati z vodo.
If you or anybody else accidentally swallows this veterinary medicinal product, seek medical advice immediately and show this leaflet or the label to your doctor.
Če vi ali kdorkoli po nesreči pogoltne zdravilo, takoj poiščite zdravniško pomoč in pokažite navodilo ali nalepko zdravniku.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Ne kadite, jejte ali pijte, medtem ko rokujete z zdravilom.
35 As a precautionary measure, direct contact with the treated animals should be avoided and children should not be allowed to play with treated animals until the application site is dry.
Prav tako ne dovolimo otrokom, da se igrajo z živalmi, ki jih zdravimo, dokler ni mesto nanosa suho.
This veterinary medicinal product is for skin application on dogs only, do not put it in your dog’ s mouth.
35 To zdravilo se uporablja samo za pse za nanos na kožo; ne dajajte ga psom v usta.
Take care to avoid the veterinary medicinal product coming into contact with your dog’ s eyes.
Pazite, da zdravilo ne zaide psu v oči.
Apply the dose to an area where the dog cannot lick it off and do not allow your dog or other animals lick each other following treatment.
Pomembno je, da nanesemo zdravilo na mesto, kjer ga pes ne bo mogel polizati in da zagotovimo, da tudi druge živali po zdravljenju ne ližejo druga druge.
If you suspect your dog may be pregnant or if your bitch is nursing puppies or if you want to treat a breeding dog, contact your veterinarian for advice before use.
Če sumite, da je vaša psica breja ali če doji, se pred uporabo zdravila posvetujte z veterinarjem.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with the local requirements.
Neporabljeno zdravilo za uporabo v veterinarski medicini ali odpadne snovi, ki nastanejo iz zdravila je treba odstraniti v skladu z lokalnimi predpisi.
The veterinary medicinal product should not be allowed to enter surface water, as it may be harmful for aquatic organisms.
Prac- tic ne sme priti v vodotoke, ker je lahko nevarno za vodne organizme.
Detailed information on this product is available on the website of the European Medicines Agency (EMEA) http: / /www. emea. europa. eu/
Podrobne informacije o tem zdravilu za uporabo v veterinarski medicini so na voljo na spletni strani Evropske agencije za zdravila (European Medicines Agency, EMEA) http: // www. emea. europa. eu
Adult fleas are killed before they lay eggs for a minimum of 4 weeks after treatment.
Piriprol ubije odrasle bolhe preden ležejo jajčeca najkasneje v 4 tednih po zdravljenju.
Novartis Animal Health UK Ltd., Tel: +44-(0)1763 850 500
Novartis Animal Health UK Ltd., Tel: +44 - (0) 1 763 850 500
Danmark:
36 Danmark:
Novartis Animal Health UK Ltd., Tel: +44-(0)1276 694402
Novartis Animal Health UK Ltd., Tel: +44 - (0) 1 276 694402
Previcox contains the active substance firocoxib, which belongs to a class of medicines having anti- inflammatory action.
Zdravilo Previcox vsebuje zdravilno učinkovino firocoxib, ki spada v razred zdravil s protivnetnimi učinki.
Previcox is presented as chewable tablets for dogs (57 mg and 227 mg) and is also authorised as an oral paste for horses (8.2 mg/ g).
Zdravilo Previcox je na voljo v obliki žvečljivih tablet za pse (57 mg in 227 mg), odobreno pa je tudi kot oralna pasta za konje (8, 2 mg/ g).
Previcox is used for a relief of pain and inflammation associated with osteoarthritis in dogs and for the alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.
Zdravilo Previcox se pri psih uporablja za lajšanje bolečin, ki so povezane z osteoartritisom, pri konjih pa za lajšanje bolečin in vnetij povezanih z osteoartritisom ter od tega odvisne šepavosti.
Previcox contains firocoxib, which belongs to a class of medicines called non-steroidal anti- inflammatory drugs (NSAIDs) belonging to the Coxib group, which acts by selective inhibition of cyclooxygenase-2 (COX-2).
Zdravilo Previcox vsebuje zdravilno učinkovino firokoksib, ki spada v razred nesteroidnih protivnetnih učinkovin (NSPVZ), natančneje v skupino koksibov, ki selektivno zavirajo encim ciklooksigenaza- 2 (COX- 2).
As the prostaglandins are substances that trigger pain, exudation and inflammation, Previcox, therefore, reduces those responses.
Ker so prostaglandini snovi, ki pomagajo sprožiti bolečino, nabiranje tekočine in vnetje, zdravilo Previcox zmanjša prisotnost teh odzivov.
Previcox has been studied in laboratory animals, as well as in dogs and horses that were treated in various veterinary practices/ clinics across Europe (“ clinical studies”).
Zdravilo Previcox so raziskovali pri laboratorijskih živalih, kot tudi psih in konjih, ki so jih zdravili v različnih veterinarskih ustanovah in klinikah po vsej Evropi (klinične raziskave).
(44-20) 74 18 84 00 Fax (44-20) 74 18 84 47 E-mail: mail@emea. europa. eu http: / /www. emea. europa. eu ©EMEA 2007 Reproduction and/ or distribution of this document is authorised for non commercial purposes only provided the EMEA is acknowledged Horse:
Konji:
Two multi-centre studies were conducted (one in the US and one in Europe) to investigate the efficacy, safety and acceptability of firocoxib under field conditions when administered to horses orally once daily for 14 days at a dose of 0.1 mg/ kg.
Da bi raziskali učinkovitost, varnost in prenašanje učinkovine firokoksib v pogojih na terenu pri peroralnem dajanju konjem enkrat dnevno v trajanju 14 dni in pri odmerku 0, 1 mg/ kg, so izvedli dve multicentrični raziskavi (eno v ZDA in eno v Evropi).
Previcox oral paste administered once daily for 14 days at a dose of 0.1 mg/ kg improved clinical scores for lameness and soft tissue injuries in horses and also helped alleviate pain and inflammation associated with osteoarthritis in horses.
Zdravilo Previcox v obliki oralne paste enkrat dnevno v času 14 dni in pri odmerku 0, 1 mg/ kg je pri konjih izboljšalo klinične ocene šepavosti in poškodb mehkih tkiv ter pomagalo lajšati bolečine in vnetja, povezana z osteoartritisom.
What are the side-effects of Previcox?
Kakšni so neželeni učinki zdravila Previcox?
The side effects of Previcox are typical for those seen with other medicines in this product class (NSAIDs) such as oral lesions (tissue damage) in the mouth of horses, soft faeces/ diarrhoea or lethargy.
Neželeni učinki zdravila Previcox, kot so oralne lezije (vrsta poškodb tkiva) v ustni votlini konj, mehko blato ali diareja in zaspanost, so značilni za vsa zdravila iz tega razreda izdelkov (NSPVZ).
Previcox must not be administered with corticosteroids or other NSAIDs.
Zdravila Previcox ne smete dajati skupaj s kortikosteroidi ali drugimi NSPVZ- ji.
Care should also be taken when used with molecules displaying action on renal flow e. g. diuretics.
Previdni morate biti tudi pri sočasni uporabi s spojinami, ki vplivajo na pretok skozi ledvice, t. j. pri diuretikih.
Wash hands after use of the product.
Po uporabi izdelka si umijte roke.
Return halved tablets to the blister and keep out of the reach of children.
Ostanke prepolovljenih tablet shranite nazaj v pretisne omote, zdravilo pa shranjujte nedosegljivo otrokom.
Women of child-bearing age should avoid contact with, or wear disposable gloves, when administering the product.
Ženske v starosti ko lahko zanosijo, bi se morale izogibati stiku z zdravilom ali pri dajanju zdravila nositi rokavice za enkratno uporabo.
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
V primeru nenamernega zaužitja se takoj posvetujte z zdravnikom in mu pokažite Navodilo za uporabo ali ovojnino zdravila.
The Committee for Medicinal Products for Veterinary Use (CVMP) concluded that the benefits of Previcox exceed the risks for the treatment of relief of pain and inflammation in both dogs and horses and recommended that Previcox be given a marketing authorisation.
Odbor za zdravila za uporabo v veterinarski medicini (CVMP) je mnenja, da so koristi zdravila Previcox pri lajšanju bolečin in vnetij pri psih in konjih večje od z njim povezanih tveganj, in je priporočil odobritev dovoljenja za promet z zdravilom Previcox.
Page 2/ 3 ©EMEA 2007 Other information about Previcox:
Stran 2/ 3 ©EMEA 2007 Druge informacije o zdravilu Previcox:
The European Commission granted the initial marketing authorisation valid throughout the European Union, for Previcox to Merial on 13 September 2004.
Evropska Komisija je prvotno dovoljenje za promet z zdravilom Previcox, veljavno po vsej Evropski uniji, odobrila družbi Merial dne 13. septembra 2004.
The extension application for the oral paste in horses was subsequently approved in February 2007.
Razširitev uporabe za oralno pasto pri konjih je bila odobrena naknadno v februarju 2007.
This summary was last updated in February 2007.
Ta povzetek je bil nazadnje posodobljen 02- 2007.
1 blister of 10 tablets
1 pretisni omotom z 10 tabletami
3 blisters of 10 tablets
3 pretisni omoti z 10 tabletami
10 tablets
10
18 blisters of 180 tablets 10 tablets
18 pretisnih omotov z 10 tabletami
Firocoxib Firocoxib
Firokoksib Firokoksib
For the relief of post-operative pain and inflammation associated with soft-tissue and orthopaedic surgery in dogs.
Za lajšanje post- operativne bolečine in blaženje vnetja povezanih z operativnimi posegi na mehkih tkivih in ortopedskimi operativnimi posegi pri psih.
Do not use concomitantly with corticosteroids or other NSAIDs.
Ne uporabite sočasno s kortikosteroidi ali drugimi NSAID.
2/ 33 Use in very young animals, or animals with suspected or confirmed impairment of renal, cardiac or hepatic function may involve additional risk.
Dodatno tveganje lahko predstavlja uporaba pri mladih živalih z morebitno okvaro delovanja ledvic, srca ali jeter.
Use this product under strict veterinary monitoring where there is a risk of gastrointestinal bleeding, or if the animal previously displayed intolerance to NSAIDs.
2/ 31 Pri uporabi zdravila pri živalih, kjer obstaja tveganje za pojav želodčno- črevesnih krvavitev ali gre za živali z znano preobčutljivostjo na druge NSAID, morajo biti te živali pod strogim veterinarskim nadzorom.
Renal and/ or hepatic disorders have been reported in very rare cases in dogs administered the recommended treatment dose.
Zelo redko so poročali o ledvičnih in jetrnih obolenjih pri psih, zdravljenih s priporočenimi odmerki.
Renal and/ or hepatic disorders have been reported in very rare cases in dogs administered the recommended treatment dose.
Zelo redko so poročali o ledvičnih in/ ali jetrnih obolenjih pri psih, zdravljenih s priporočenimi odmerki.
Pre-treatment with other anti-inflammatory substances may result in additional or increased adverse effects and accordingly a treatment-free period with such drugs should be observed for at least 24 hours before the commencement of treatment with Previcox.
Zato je potrebno preden začnemo z zdravljenjem z zdravilom Previcox, počakati vsaj 24 ur.
Concomitant treatment with molecules displaying action on renal flow, e. g. diuretics or Angiotensin Converting Enzyme (ACE) inhibitors, should be subject to clinical monitoring.
Sočasno zdravljenje z molekulami, ki vplivajo na pretok skozi ledvice npr. diuretiki ali inhibitorji angiotenzin konvertaze (ACE), mora biti pod strogim veterinarskim nadzorom.
Concurrent administration of potentially nephrotoxic drugs should be avoided as there might be an increased risk
Izogibajte se sočasni uporabi z drugimi nefrotoksičnimi zdravili, ker obstaja povečana nevarnost toksičnega vpliva na ledvice.
4.9 Amounts to be administered and administration route
3/ 31 4. 9 Odmerjanje in pot uporabe
Relief of post-operative pain Administer 5 mg per kg bodyweight once daily as presented in the table below for up to 3 days as needed, starting approximately 2 hours prior to surgery.
Zdravimo po potrebi do 3 zaporedne dni; prvi odmerek damo približno 2 uri pred operativnim posegom.
Number of chewable tablets by size 57 mg 227 mg
Število žvečljivih tablet glede na mg/ kg obseg
mg/ kg range
Telesna masa (kg)
0.5
57 mg
5.6 –
njihovo
5.7 – 10.2
velikost 227 mg
In dogs ten weeks of age at the start of treatment at dose rates equal or greater to 25 mg/ kg/ day (5 times the recommended dose) for three months, the following signs of toxicity were observed: bodyweight loss, poor appetite, changes in the liver (accumulation of lipid), brain (vacuolisation), duodenum (ulcers) and death.
Pri psih, ki so bili ob začetku raziskave stari 10 tednov, so se po treh mesecih prejemanja odmerkov enakih ali višjih od 25 mg/ kg/ dan (petkratni priporočeni odmerek) pojavila naslednja znamenja toksičnosti: izguba telesne mase, slabši apetit, spremembe v jetrih (nakopičenje lipidov), možganih (vakuolizacija), dvanajstniku (razjede) in pogin živali.
At dose rates equal or greater to 15 mg/ kg/ day (3 times the recommended dose) for six months, similar clinical signs were observed, albeit that the severity and frequency were less and duodenal ulcers were absent.
Podobna klinična znamenja so se pojavila po šestih mesecih pri odmerkih višjih od 15 mg/ kg/ dan, (trikratni priporočeni odmerek), čeprav so bila manj resna, manj pogosta in ni bilo razjed dvanajstnika.
In dogs seven months of age at the start of treatment at dose rates greater than or equal to 25 mg/ kg/ day (5 times the recommended dose) for six months, gastrointestinal adverse effects, i. e. vomiting were observed.
Pri psih, ki so bili ob začetku raziskave stari 7 mesecev in so šest mesecev prejemali odmerke 25 mg/ kg/ dan ali višje (petkratni priporočeni odmerek), niso opazili stranskih učinkov v prebavilih t. j. bruhanja.
4/ 33 4.11 Withdrawal period(s)
4. 11 Karenca
ATCvet code:
Nesteroidna protivnetna in protirevmatična zdravila ATCvet oznaka:
5.1 Pharmacodynamic properties
4/ 31 5. 1 Farmakodinamične lastnosti
Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) belonging to the Coxib group, which acts by selective inhibition of cyclooxygenase-2 (COX-2) – mediated prostaglandin synthesis.
Firokoksib je nesteroidno protivnetno zdravilo (NSAID), ki pripada skupini koksibov, in ki selektivno zavirajo delovanje ciklooksigenaze- 2 (COX- 2) v sintezi prostaglandinov.
COX-2 is the isoform of the enzyme that has been shown to be induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever.
Predvnetni dražljaj sproži nastanek COX- 2 izoformne oblike encima, ki je po ugotovitvah prvotno odgovoren za sintezo prostanoidnih mediatorjev bolečine, vnetja in povišane telesne temperature.
In in-vitro canine whole blood assays, firocoxib exhibits approximately 380-fold selectivity for COX-2 over COX-1.
Raziskave krvi pri psu in vitro so pokazale, da firokoksib 380 krat bolj selektivno deluje na COX- 2 kot na COX- 1.
The concentration of firocoxib required to inhibit 50% of the COX-2 enzyme (i. e., the IC50) is 0.16 (± 0.05) µM, whereas the IC50 for COX-1 is 56 (± 7) µM.
50 odstotno inhibicijo COX- 2 encima (t. j IC50) dosežemo s koncentracijo 0, 16 (± 0, 05) µM firokoksiba, medtem ko IC50 za COX- 1 znaša 56 (± 7) µM.
Following oral administration in dogs at the recommended dose of 5 mg per kg of bodyweight, firocoxib is rapidly absorbed and the time to maximal concentration (Tmax) is 1.25 (± 0.85) hours.
Po peroralnem dajanju zdravila pri psih v priporočenem odmerku 5 mg na kg telesne mase se firokoksib hitro absorbira in v 1, 25 (± 0, 85) urah doseže maksimalno koncentracijo( Tmax).
The peak concentration (Cmax) is 0.52 (± 0.22) µg/ ml (equivalent to approximately 1.5 µM), area under the curve (AUC 0-24) is 4.63 (±1.91) µg xhr/ ml, and oral bioavailability is 36.9 (±20.4) percent.
Najvišja vrednost koncentracije (Cmax) je 0, 52 (± 0, 22) µg/ ml (kar ustreza približno 1, 5 µM), površina pod krivuljo (AUC 0- 24) je 4, 63 (±1, 91) µg xhr/ ml, in oralna biorazpoložljivost je 36, 9 (±20, 4)%.
The elimination half-life (t½) is 7.59 (± 1.53) hours.
Razpolovna doba izločanja (t½) je 7, 59 (± 1, 53) ur.
Firocoxib is approximately 96% bound to plasma proteins.
Firokoksib se v približno 96% veže na plazemske proteine.