natgillin/translations-raw huggingface dataset:
WHAT RAPAMUNE IS AND WHAT IT IS USED FOR
KAJ JE ZDRAVILO RAPAMUNE IN ZA KAJ GA UPORABLJAMO
Rapamune belongs to a group of medicines called immunosuppressants.
Zdravilo Rapamune sodi med zdravila za zaviranje imunske odzivnosti.
It helps to control your body’ s immune system after you have received an organ transplant.
Po presaditvi organa pomaga nadzorovati vaš imunski sistem.
It is used to prevent your body from rejecting transplanted kidneys and is normally used with medicines called corticosteroids and initially with ciclosporin.
Uporablja se za preprečevanje zavrnitve presajene ledvice, običajno skupaj z drugimi zdravili, kot so kortikosteroidi in na začetku s ciklosporinom.
BEFORE YOU TAKE RAPAMUNE
KAJ MORATE VEDETI, PREDEN BOSTE VZELI ZDRAVILO RAPAMUNE
Do not take Rapamune  if you are allergic (hypersensitive) to sirolimus or any of the other ingredients of Rapamune.
- če imate ali ste imeli težave z jetri ali kakšno drugo bolezen, ki bi lahko prizadela vaša jetra.
Take special care with Rapamune  if you have any liver problems or have had a disease which may have affected your liver, please tell your doctor as this may affect the dose of Rapamune that you receive.  immunosuppressive medicines may decrease your body ’ s ability to fight infection, and may increase the risk of developing cancer of the lymphoid tissues and skin.
Prosimo, obvestite o tem svojega zdravnika, ker bo morda prilagodil odmerek zdravila, ki ga boste prejemali.
Your doctor will perform tests to monitor the levels of Rapamune in your blood.
Med zdravljenjem bo vaš zdravnik s posebnimi laboratorijskimi preiskavami ugotavljal koncentracijo zdravila v vaši krvi.
Your doctor will also perform tests to monitor your kidney function and, possibly, your liver function, during therapy with Rapamune.
Prav tako bo s preiskavami spremljal delovanje vaših ledvic, morda pa tudi jeter v času zdravljenja s tem zdravilom.
Exposure to sunlight and UV light should be limited by wearing protective clothing and using a sunscreen with a high protection factor because of the increased risk for skin cancer.
Med zdravljenjem omejite izpostavljanje neposrednim sončnim in UV žarkom z nošenjem zaščitnih oblačil in uporabo kreme z visokim zaščitnim faktorjem zaradi povečanega tveganja za nastanek kožnega raka.
Taking other medicines Please tell your doctor or pharmacist if you are taking, or have recently taken any other medicines, including those obtained without a prescription.
Uporaba drugih zdravil Obvestite svojega zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katerokoli zdravilo, tudi če ste ga dobili brez recepta.
Some medicines can interfere with the action of
- zdravila za zdravljenje zvišanega krvnega tlaka ali za zdravljenje bolezni srca, kot so: nikardipin,
67 Rapamune.
verapamil in diltiazem,
In particular, you should inform your doctor or pharmacist if you are taking any of the following:  any other immunosuppressive agents excluding ciclosporin or corticosteroids.  antibiotics or antifungal medicines used to treat infection e. g. rifampicin, clarithromycin, erythromycin, telithromycin, troleandomycin, rifabutin, clotrimazole, fluconazole, itraconazole, ketoconazole and voriconazole.  high blood pressure medicines or medicines for heart problems including nicardipine, verapamil and diltiazem.  anti-epileptic medicines including carbamazepine, phenobarbital, phenytoin.  medicines used to treat-ulcers or other gastrointestinal disorders such as cisapride, cimetidine, metoclopramide.  bromocriptine (used in the treatment of Parkinsons’ disease and various hormonal disorders), danazol (used in the treatment of gynaecological disorders), or protease inhibitors (used in the treatment of HIV).  St.
motenj), danazol (za zdravljenje ginekoloških bolezni) ali zaviralce proteaz (za zdravljenje okužb s HIV),
John’ s Wort (Hypericum perforatum).
- pripravke šentjanževke (Hypericum perforatum).
The use of Rapamune may lead to increased blood concentrations of cholesterol and triglycerides that may require treatment.
Uporaba zdravila Rapamune lahko povzroči povečano raven holesterola in trigliceridov v krvi, ki jo je treba zdraviti.
Medicines known as “ statins” and “ fibrates” used to treat elevated cholesterol and triglycerides have been associated with an increased risk of muscle breakdown (rhabdomyolysis).
Uporaba zdravil iz skupin statinov in fibratov, ki se uporabljajo za zdravljenje povečane ravni holesterola in trigliceridov, je bila povezana s povečanim tveganjem za pojav mišične razgradnje (rabdomioliza).
Please inform your doctor if you are taking drugs to lower your blood fats.
Če jemljete zdravila za zniževanje koncentracije maščob v krvi, to povejte svojemu zdravniku.
Taking Rapamune with food and drink Rapamune should be taken consistently, either with or without food.
Jemanje zdravila Rapamune skupaj s hrano in pijačo Zdravilo Rapamune jemljite vedno enako ali s hrano ali na tešče.
Rapamune should be diluted only with water or orange juice.
Zdravilo Rapamune lahko razredčite samo z vodo ali s pomarančnim sokom.
Do not take Rapamune with grapefruit juice.
Ne razredčujte zdravila Rapamune s sokom grenivke.
Pregnancy and breast feeding You must use effective contraception methods during treatment with Rapamune and for 12 weeks after treatment has stopped.
Nosečnost in dojenje Med zdravljenjem z zdravilom Rapamune in še 12 tednov po prenehanju jemanja zdravila morate uporabljati učinkovito zaščito pred zanositvijo.
Decreased sperm count has been associated with the use of Rapamune and usually resolves after discontinuation.
Z jemanjem zdravila Rapamune je bilo povezano zmanjšanje števila semenčic, ki se po prekinitvi jemanja zdravila navadno popravi.
Patients taking Rapamune should discontinue breast-feeding.
Ni znano, ali zdravilo Rapamune prehaja v materino mleko, zato morate prenehati z dojenjem, če se zdravite z njim.
Use in children and adolescents There is limited experience with the administration of Rapamune in children and adolescents.
Uporaba pri otrocih in mladostnikih Izkušnje z uporabo zdravila Rapamune pri otrocih in mladostnikih so omejene.
Driving and using machines No specific studies on the effects of Rapamune on the ability to drive and use machines have been conducted.
Vpliv na sposobnost upravljanja vozil in strojev Študije o vplivu zdravila Rapamune na sposobnost vožnje in upravljanja s stroji niso bile izvedene.
Although Rapamune treatment is not expected to affect your ability to drive, if you have any concerns please consult your doctor.
Čeprav ni pričakovati, da bi zdravilo Rapamune vplival na vašo sposobnost vožnje, se posvetujte z zdravnikom, če ste v dvomih.
Important information about one of the ingredients of Rapamune WARNING:
Pomembne informacije o nekaterih sestavinah zdravila Rapamune OPOZORILO:
This medicine contains 1.5% to 2.5% ethanol.
Zdravilo vsebuje od 1, 5% do 2, 5% alkohola.
Each 2 mg dose contains up to 50 mg of alcohol.
Vsak odmerek po 2 mg vsebuje do 50 mg alkohola.
Alcohol may be harmful for those suffering from alcoholism, epilepsy, brain injury or disease as well as for pregnant women and children.
Alkohol lahko škoduje alkoholikom, bolnikom z epilepsijo, možganskimi poškodbami ali boleznimi ter nosečnicam in otrokom.
HOW TO TAKE RAPAMUNE
KAKO JEMATI ZDRAVILO RAPAMUNE
Always take Rapamune exactly as your doctor has told you.
Pri jemanju zdravila Rapamune natančno upoštevajte zdravnikova navodila.
Your doctor will decide exactly what dose of Rapamune you must take and how often to take it.
Vaš zdravnik se bo odločil, kakšen odmerek morate jemati in kako pogosto.
Follow your doctor’ s instructions exactly and never change the dose yourself.
Natančno upoštevajte zdravnikova navodila in nikoli ne spreminjajte odmerka sami.
Do not stop taking your medicine unless your doctor tells you to.
Ne prekinjajte zdravljenja, razen če vam tako svetuje zdravnik.
If you stop taking your medicine, you risk losing your transplant.
Če ste prenehali jemati zdravilo, tvegate izgubo transplantata.
Usually for an adult your doctor will give you an initial dose of 6 mg at the time of the kidney transplant operation.
67 Če ste odrasla oseba, vam bo zdravnik običajno predpisal začetni odmerek 6 mg v času operacije presaditve ledvice.
Then you will need to take 2 mg of Rapamune each day, unless otherwise directed by your doctor.
Potem boste morali jemati po 2 mg zdravila Rapamune vsak dan (razen če bo zdravnik odločil drugače).
Your dose will be adjusted depending on the level of Rapamune in your blood.
Odmerek zdravila bo morda spremenil, odvisno od njegove koncentracije v vaši krvi.
Your doctor will need to perform a blood test to measure Rapamune concentrations.
Za določitev te koncentracije vas bo zdravnik napotil na krvne preiskave.
With the plunger fully depressed, insert one of the dosing syringes into the opening in the adapter.
Bat v odmerni brizgi naj bo pritisnjen do konca.
Once in the syringe the medication may be kept at room temperature (not exceeding 25 C) or refrigerated and should be used within 24 hours.
Zdravilo morate porabiti v 24 urah.
Empty the contents of the dosing syringe into only a glass or plastic container holding at least 60 ml of water or orange juice.
Iztisnite vsebino odmerne brizge v steklen ali plastičen kozarček v katerem je najmanj 60 ml vode ali pomarančnega soka.
Stir well for one minute and drink immediately.
Mešajte vsaj eno minuto in takoj popijte.
Refill the glass with at least 120 ml of water or orange juice, stir well, and drink immediately.
V kozarec ponovno nalijte 120 ml vode ali pomarančnega soka, še enkrat dobro premešajte in takoj popijte.
No other liquids, including grapefruit juice, should be used for dilution.
68 grenivke, ne uporabljajte za razredčenje.
When refrigerated the solution in the bottle may develop a slight haze.
Če shranjujete zdravilo Rapamune v hladilniku lahko raztopina v steklenici rahlo pomotni.
If this occurs, simply bring your Rapamune 1 mg/ 1 ml oral solution to room temperature and shake gently.
Če se to zgodi, dajte steklenico z raztopino (1mg/ 1ml) na sobno temperaturo in jo previdno pretresite.
If you take more Rapamune than you should If you have taken more medicine than you were told contact a doctor or go to the nearest hospital emergency department straight away.
Če ste vzeli večji odmerek zdravila Rapamune, kot bi smeli Če ste vzeli večji odmerek zdravila kot vam je bilo predpisano, pojdite čimprej k zdravniku ali na urgentni oddelek najbližje bolnišnice.
Always take the labelled medicine bottle with you, even if it is empty.
S seboj vzemite steklenico zdravila, tudi če je prazna.
If you forget to take Rapamune If you forget to take Rapamune, take it as soon as you remember, but not within 4 hours of the next dose of ciclosporin.
Če ste pozabili vzeti zdravilo Rapamune Če ste pozabili vzeti zdravilo Rapamune, ga vzemite takoj, ko se spomnite, vendar ne manj kot 4 ure pred naslednjim odmerkom ciklosporina.
After that, continue to take your medicines as usual.
Ne vzemite dvojnega odmerka, da bi nadomestili pozabljenega.
Do not take a double dose to make up for a forgotten dose, and always take Rapamune and ciclosporin approximately 4 hours apart.
Zdravilo Rapamune in ciklosporin vzemite vedno vsaj 4 ure narazen.
If you miss a dose of Rapamune completely, you should inform your doctor.
Če popolnoma pozabite vzeti posamezen odmerek zdravila Rapamune, morate o tem obvestiti svojega zdravnika.
Like all medicines, Rapamune can cause side effects, although not everybody gets them.
Kot vsa zdravila ima lahko tudi zdravilo Rapamune neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
However, since Rapamune is taken in combination with other medicines, the side effects cannot always be attributed with absolute certainty to Rapamune.
Ker pa zdravilo Rapamune jemljete sočasno z drugimi zdravili, neželenih učinkov ni vedno mogoče zagotovo pripisati prav njemu.
When taken with medicines called calcineurin inhibitors (ciclosporin or tacrolimus), Rapamune may increase the risk of kidney damage with low blood platelets and low red blood cell counts with or without rash (thrombocytopenic purpura/ haemolytic uraemic syndrome).
Kadar jemljete zdravilo Rapamune sočasno z zdravili imenovanimi zaviralci kalcinevrina (ciklosporin ali takrolimus), se lahko poveča tveganje za okvaro ledvic z zmanjšanjem števila krvnih ploščic in rdečih krvničk, z ali brez izpuščaja (trombocitopenična purpura, hemolitično uremični sindrom).
Immunosuppressants, including Rapamune, reduce your body’ s own defence mechanisms to stop you rejecting your transplanted organ.
Imunosupresivi, med drugim tudi zdravilo Rapamune, zavirajo lastne obrambne mehanizme vašega telesa, da bi preprečili zavrnitev presajenega organa.
Consequently your body will not be as good as normal at fighting infections.
Zato vaše telo v borbi proti okužbam ne bo tako uspešno kot sicer.
So if you are taking Rapamune you may therefore catch more infections than usual such as infections of the skin, mouth, stomach and intestines, lungs and urinary tract.
Če jemljete zdravilo Rapamune, boste zato mogoče imeli več okužb kot navadno, na primer okužbe kože, ust, želodca in črevesja, pljuč in sečil.
70 Possible side effects of Rapamune are listed according to the following categories:
Možni neželeni učinki zdravila Rapamune so navedeni po naslednjih kategorijah:
Very common: more than 1 per 10 Common: less than 1 per 10 but more than 1 per 100 Uncommon: less than 1 per 100 but more than 1 per 1000 Rare: less than 1 per 1000
pri manj kot 1 od 10, vendar več kot 1 od 100 bolnikov pri manj kot 1 od 100, vendar več kot 1 od 1. 000 bolnikov pri manj kot 1 od 1. 000 bolnikov
 Body as a whole:
• Telo kot celota:
Fluid collection around the kidney, swelling of the extremities, fever, pain Impaired healing (this may include separation of the layers of a surgical wound or suture line), swelling, infections (including life-threatening infections)
nabiranje tekočine okrog ledvic, otekanje okončin, zvišana telesna temperatura, bolečina
 Nervous system
Pogosti:
disorders:
• Bolezni živčevja:
Very common:
69 Zelo pogosti:
 Cardiac disorders:
• Srčne bolezni:
Rapid heart rate Fluid collection in the sac around the heart that, in some cases, may decrease the heart's ability to pump blood
hitro bitje srca kopičenje tekočine v vreči, ki obdaja srce, kar lahko v nekaterih primerih zmanjša sposobnost srca za črpanje krvi
 Blood vessel disorders:
• Žilne bolezni:
Increased blood pressure Blood clots in the legs Blood clots in the lung
zvišan krvni tlak krvni strdki v spodnjih okončinah krvni strdki v pljučih
 Gastrointestinal reactions:
• Bolezni prebavil:
Abdominal pain, diarrhoea, constipation, nausea Mouth sores Inflammation of the pancreas
bolečine v trebuhu, driska, zaprtje, navzea vnetje ustne sluznice vnetje trebušne slinavke
 Blood and lymph disorders:
• Bolezni krvi in limfatičnega sistema:
Low red blood cells, low blood platelets Kidney damage with low blood platelets and low red blood cell counts with or without rash (thrombocytopenic purpura/ haemolytic uraemic syndrome), a reduced number of infection fighting cells in the blood (white blood cells), low levels of a type of white blood cells called neutrophils
zmanjšanje števila rdečih krvničk, zmanjšanje števila krvnih ploščic okvara ledvic z zmanjšanjem števila krvnih ploščic in rdečih krvničk, z ali brez izpuščaja (trombocitopenična purpura, hemolitično uremični sindrom), zmanjšano število krvničk, ki se borijo proti okužbam (bele krvničke), nizek nivo belih krvnih celic imenovanih nevtrofilci
Cancer of the lymph tissue (lymphoma/ post-transplant lympho-proliferative disorder), combined lowering of red blood cells, white blood cells and blood platelets
rak limfnega tkiva (limfom, limfoproliferativne motnje po presaditvi) kombinirano zmanjšanje števila rdečih krvničk, belih krvničk in krvnih ploščic
Too much fluid collecting in the tissues due to irregular lymph function
zaradi motenega odtoka limfe v tkivu zastaja preveč limfne tekočine
 Immune system disorders:
• Bolezni imunskega sistema:
Allergic reactions including those that are life-threatening
alergične reakcije vključno z življenjsko ogrožujočimi
71  Metabolism and nutrition disorders:
• Presnovne in prehranske motnje:
Elevated cholesterol, elevated blood sugar, elevated fat in the blood, low blood potassium, low blood phosphorus, elevated lactate dehydrogenase protein in the blood, elevated creatinine in the blood
zvišan holesterol, zvišan krvni sladkor, zvišane maščobe v krvi, nizke vrednosti kalija v krvi, nizke vrednosti fosfata v krvi, zvišanje laktat- dehidrogenaze (LDH) v krvi, zvišanje kreatinina v krvi
Abnormal tests of liver function, elevated AST and/ or ALT liver enzymes
nenormalne vrednosti testov jetrnih funkcij (zvišanje jetrnih encimov AST in/ ali ALT)
 Bone and joint disorders:
• Bolezni mišično- skeletnega sistema in vezivnega tkiva:
Joint pain Deterioration of bone
bolečine v sklepih poslabšanje kakovosti kosti
disorders:
• Bolezni dihal, prsnega koša in mediastinalnega prostora:
Pneumonia and other causes of inflammation that may lead to lung damage, fluid around the lung, nose bleeds
pljučnica in drugi vzroki vnetja, ki lahko povzročijo okvaro pljuč, kopičenje tekočine okrog pljuč, krvavitve iz nosu
Protein build-up in the air sacs of the lungs that may interfere with breathing
krvavitve iz pljuč nabiranje beljakovin v zračnih mešičkih v pljučih, kar lahko ovira dihanje
 Skin disorders:
• Bolezni kože in podkožja:
Very common:
70 Zelo pogosti:
Acne Skin cancer, rash
akne kožni rak, izpuščaj
 Kidney disorders:
• Bolezni sečil:
Urinary tract infection Kidney infection; protein in the urine Protein in the urine, occasionally severe and associated with side effects such as swelling
okužbe sečil okužbe ledvic, beljakovine v urinu beljakovine v urinu, včasih jih je veliko in so povezane z neželenimi učinki, na primer otekanjem
Serious liver damage has also been reported.
Poročali so tudi o hudih okvarah jeter.
Scarring in the kidney that may reduce kidney function has been reported.
Poročali so o brazgotinjenju ledvic, kar lahko zmanjša ledvično delovanje.
The above side effects may require medical intervention and some may be life-threatening or fatal.
Navedeni neželeni učinki bodo morda zahtevali zdravniško pomoč, nekateri pa so lahko tudi življenjsko ogrožujoči ali celo usodni.
You should see your doctor immediately if you experience symptoms such as swollen face, tongue and/ or pharynx (back of the mouth) and/ or difficulties in breathing (angioedema), or a skin condition whereby the skin can peel off (exfoliative dermatitis).
Nemudoma obiščite svojega zdravnika, če opazite katerega od simptomov kot so otekel obraz, jezik in/ ali žrelo (ozadje ustne votline) in/ ali težave z dihanjem (angioedem) ali kožno bolezen, pri kateri se lahko koža odlušči (eksfoliativni dermatitis).
If you are concerned about any side effect or if you notice any other effects not mentioned in this leaflet, please inform your doctor or pharmacist.
Če katerikoli neželeni učinek postane resen ali če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.
HOW TO STORE RAPAMUNE
SHRANJEVANJE ZDRAVILA RAPAMUNE
Do not use Rapamune after the expiry date which is stated on the carton after EXP:
Zdravila Rapamune ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli poleg oznake Uporabno do:.
Keep Rapamune oral solution in its original bottle in order to protect from light.
Zdravilo Rapamune peroralno raztopino shranjujte v originalni steklenici za zagotovitev zaščite pred svetlobo.
Store in a refrigerator (2 C -8 C).
Shranjujte v hladilniku (2 oC - 8 oC).
If necessary, you may store the bottles at room temperature up to 25 C for a short period of time (no longer than 24 hours).
Po potrebi lahko steklenice krajši čas shranjujete tudi pri sobni temperaturi do 25 oC (ne več kot 24 ur).
72 Medicines should not be disposed of via wastewater or household waste.
Zdravila na smete odvreči v odpadne vode ali med gospodinjske odpadke.
What Rapamune contains The active substance is sirolimus.
Kaj vsebuje zdravilo Rapamune Zdravilna učinkovina je sirolimus.
Each ml of Rapamune contains 1 mg of sirolimus.
1 ml peroralne raztopine zdravila Rapamune vsebuje 1 mg sirolimusa.
Polysorbate 80 and phosal 50 PG (phosphatidylcholine, propylene glycol, monodiglycerides, ethanol (1.5% to 2.5%), soya fatty acids, and ascorbyl palmitate).
Pomožne snovi so: polisorbat 80, Phosal 50 PG (fosfatidilholin, propilenglikol, monogliceridi, digliceridi, etanol (1, 5% do 2, 5%), maščobne kisline iz soje in askorbilpalmitat).
What Rapamune looks like and contents of the pack
71 Izgled zdravila Rapamune in vsebina pakiranja
Rapamune oral solution is supplied in 60 ml amber glass bottles.
Zdravilo Rapamune peroralna raztopina je na voljo v 60 ml steklenicah iz rjavega stekla.
United Kingdom.
Kildare Berkshire, SL6 0PH Irska Velika Britanija
Wyeth Pharmaceuticals New Lane Havant Hampshire PO9 2NG United Kingdom
Wyeth Pharmaceuticals New Lane Havant Hampshire PO9 2NG Velika Britanija
België/ Belgique/ Belgien Luxembourg/ Luxemburg Wyeth Pharmaceuticals S. A. / N. V.
Wyeth Pharmaceuticals Luxembourg/ Luxemburg Tel: +48 22 457 1000 Tel: +353 1 449 3500 Wyeth Pharmaceuticals Fax: +48 22 457 1001 Fax: +353 1 679 3773 S. A. / N. V.
73 Deutschland Wyeth Pharma GmbH Tel: +49 180 2 29 93 84 Fax: +49 251 204 1128
Wyeth Pharma GmbH
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Fax: + 358 20 7414 879
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Sverige Wyeth AB Tel: +46 8 470 3200
T : +30 2 10 99 81 600 Φαξ: +30 2 10 99 21 994
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Malta Vivian Corporation Ltd.
Fax: +36 1 240 4632
Tel: +35621 344610 Fax: +35621 341087
Fax: +46 8 730 0666
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72 United Kingdom Malta Ελλάδα Wyeth Pharmaceuticals Vivian Corporation Ltd.
España Wyeth Farma S. A.
Wyeth Hellas A. E. B. E.
Tel: +34 91 334 65 65 Fax: +34 91 663 65 53
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Norge France Wyeth Wyeth Tlf: +47 40 00 23 40 Pharmaceuticals France Fax: +47 40 00 23 41 Tél: +33 1 41 02 70 00 Fax: +33 1 41 02 70 10
This leaflet was last approved in:
Navodilo je bilo odobreno
Detailed information on this medicine is available on the European Medicines Agency (EMEA) website: http: / /www. emea. europa. eu
Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila (EMEA) http: // www. emea. europa. eu.
Rapamune belongs to a group of medicines called immunosuppressants.
Rapamune sodi med zdravila za zaviranje imunske odzivnosti.
Do not take Rapamune  if you are allergic (hypersensitive) to sirolimus or any of the other ingredients in the tablet.
- če imate ali ste imeli težave z jetri ali kakšno drugo bolezen, ki bi lahko prizadela vaša jetra.
Taking other medicines Please tell your doctor or pharmacist if you are taking, or have recently taken any other medicines, including those obtained without a prescription.
74 Uporaba drugih zdravil Obvestite svojega zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katerokoli zdravilo, tudi če ste ga dobili brez recepta, saj lahko nekatera zdravila vplivajo na delovanje zdravila Rapamune.
Some medicines can interfere with the action of
- antibiotike ali protiglivična zdravila za zdravljenje okužb, kot so: rifampicin, klaritromicin,
75 Rapamune.
verapamil in diltiazem,