natgillin/translations-raw huggingface dataset:
If you have trouble with your kidneys or liver, or with your adrenal, pituitary or thyroid glands If you are drinking alcohol: watch for signs of a hypo and never drink alcohol on an empty ro
Pri uporabi zdravila Velosulin bodite posebej pozorni, e imate težave z ledvicami, jetri, nadledvi no žlezo, hipofizo ali š itnico; a
stomach If you are exercising more than usual or if you want to change your usual diet lp
pijete alkohol: pazite na znake hipe in alkohola nikdar ne pijte na prazen želodec; m
If you are ill: carry on taking your insulin If you are going abroad: travelling over time zones may affect your insulin needs and the a
ste telesno bolj dejavni kot ponavadi ali želite spremeniti svojo obi ajno prehrano; ste bolni: insulin uporabljajte še naprej; ni
timing of your injections. in
potujete v tujino: potovanje med razli nimi asovnimi pasovi lahko vpliva na potrebe po insulinu in asovni razpored injekcij. lo
Using other medicines ic ed
Uporaba drugih zdravil vi ra
Talk to your M
Zd
doctor or pharmacist if you take or have recently taken any other medicines, even those not prescribed.
Posvetujte se z zdravnikom, e jemljete ali ste jemali katero koli drugo zdravilo, tudi e ste ga dobili brez recepta.
Your need for insulin may change if you also take: oral antidiabetic products; monoamine oxidase inhibitors (MAOI); beta-blockers; ACE-inhibitors; acetylsalicylic acid; anabolic steroids; sulphonamides; oral contraceptives; thiazides; glucocorticoids; thyroid hormone therapy; beta- sympathomimetics; growth hormone; danazol; octreotide or lanreotide.
Vaša potreba po insulinu se lahko spremeni, e uporabljate tudi: peroralne antidiabetike; zaviralce monoaminooksidaze (MAOI); zaviralce beta; zaviralce ACE; acetilsalicilno kislino; anabolne steroide; sulfonamide; peroralne kontraceptive; tiazide; glukokortikoide; zdravljenje s š itni nimi hormoni; beta- simpatikomimetike; rastni hormon; danazol; oktreotid ali lanreotid.
Pregnancy and breast-feeding
22 Nose nost in dojenje
If you are pregnant, planning a pregnancy or breast-feeding: please contact your doctor for advice.
e ste nose i, nameravate zanositi ali dojite: za nasvet prosite svojega zdravnika.
23 Driving and using machines
Vpliv na sposobnost upravljanja vozil in strojev
If you drive or use tools or machines: watch out for signs of a hypo.
e vozite ali uporabljate orodja ali stroje: pazite na znake hipe.
Discuss with your doctor whether you can drive or use machines at all, if you have a lot of hypos or if you find it hard to recognise hypos.
Nikdar ne vozite in ne uporabljajte strojev, e utite, da se pojavlja hipa. Z zdravnikom se posvetujte, ali lahko sploh vozite ali upravljate s stroji, e doživljate veliko hip ali hipe težko prepoznate.
3.
et 3.
Talk about your insulin needs with your doctor and diabetes nurse.
m o O svoji potrebi po insulinu se posvetujte z zdravnikom in diabetološko sestro.
Follow their advice carefully.
Natan no upoštevajte
This leaflet is a general guide.
pr njihova navodila.
ed If your doctor has switched you from one type or brand of insulin to another, your dose may have to be adjusted by your doctor.
To navodilo za uporabo obsega splošna navodila. e vam zdravnik eno vrsto ali znamko insulina zamenja z drugo, vam bo morda moral prilagoditi odmerek.
is Eat a meal or snack containing carbohydrates within 30 minutes of administration.
za V 30 minutah po uporabi pojejte obrok ali prigrizek, ki vsebuje ogljikove hidrate.
th au Check the label to make sure it is the right type of insulin Disinfect the rubber membrane with a medicinal swab.
a nj Preden uporabite Velosulin preverite nalepko, da se boste prepri ali, ali imate pravo vrsto insulina; lje dezinficirajte gumijasto membrano z medicinskim zložencem. vo
er Do not use Velosulin ng If the protective cap is loose or missing.
Ne uporabljajte zdravila Velosulin: e zaš itna zaporka ni trdno pri vrš ena ali je sploh ni.
Each vial has a protective, tamper-proof plastic cap.
Vsaka viala ima zaš itno, varovalno do
If it hasn’ t been stored correctly or been frozen (see 6 How to store Velosulin) If it does not appear water clear and colourless. no
Shranjevanje zdravila ā
Use in infusion pump ct
Velosulin). ve
Follow the instructions and recommendations from your doctor regarding the use of Velosulin in a du
e ni bistro kot voda in brezbarvno. a
Velosulin should never be mixed with any other insulin when used in a pump. ro
Upoštevajte zdravnikova navodila in priporo ila o uporabi zdravila Velosulin v rpalki. ni
Read and follow carefully the instructions that accompany your insulin pump.
e Velosulin uporabljate v rpalki, ga nikoli ne smete mešati z nobenim drugim insulinom.
Always have ordinary syringes available in case of pump interruption or failure. lp
Preberite in natan no upoštevajte navodila, priložena vaši insulinski rpalki. lo
Use in syringes a in
Uporaba v brizgah ra
Always vary the sites you inject, to avoid lumps (see 5 Possible side effects).
boste prepre ili nastanek zatrdlin (glejte poglavje 5.
The best places to give yourself an injection are: the front of your ic
Možni neželeni u inki).
Your insulin will work more ed
Najprimernejša mesta za injiciranje so: sprednji del trebuha (abdomen), zadnjica in sprednji del stegen ali nadlakti.
quickly if you inject it around the waist.
Insulin bo deloval hitreje, e ga injicirate v predelu trebuha.
M
Viale zdravila Velosulin so namenjene uporabi z insulinskimi brizgami, ki imajo ustrezno odmerno skalo.
1.
Za injiciranje zdravila Velosulin samega 1.
Turn the vial and syringe upside down 4.
Obrnite vialo in brizgo tako, da bo viala na vrhu.
Check you have the right dose 24 8.
Preverite, da imate nastavljen pravi odmerek.
Use the injection technique advised by your doctor or diabetes nurse 9.
Za injiciranje uporabite postopek, ki vam ga je svetoval zdravnik ali diabetološka sestra.
ed If you get a hypo
m o e doživite hipo
is A hypo means your blood sugar level is too low.
pr Hipa pomeni, da imate prenizek sladkor v krvi.
The warning signs of a hypo may come on suddenly and can include: cold sweat; cool pale skin;
Opozorilni znaki hipe se lahko pojavijo nenadoma in lahko obsegajo: hladno znojenje, hladno in
or headache; rapid heart beat; feeling sick; feeling very hungry; temporary changes in vision; drowsiness; unusual tiredness and weakness; nervousness or tremor; feeling anxious; feeling
za bledo kožo, glavobol, hitro bitje srca, ob utek slabosti, hudo lakoto, prehodne spremembe vida, zaspanost, nenavadno utrujenost in šibkost, živ nost ali tresenje, ob utek tesnobe, ob utek
th confused; difficulty in concentrating.
a zmedenosti, težave s koncentracijo.
au If you get any of these signs, eat glucose tablets or a high sugar snack (sweets, biscuits, fruit juice), then rest.
nj e se pojavi kateri od teh znakov, zaužijte tablete glukoze ali prigrizek, ki vsebuje veliko sladkorja (bonbone, piškote, sadni sok), in nato po ivajte. lje e utite, da se pojavlja hipa, si ne dajajte insulina.
Don’ t take any insulin if you feel a hypo coming on.
Za vsak primer vedno imejte pri sebi tablete glukoze, bonbone, piškote ali sadni sok. vo
er Carry glucose tablets, sweets, biscuits or fruit juice with you, just in case.
Ne smejo vam do
Tell your relatives, friends and close colleagues that if you pass out (become unconscious), they ng must: turn you on your side and seek medical advice straight away.
dajati hrane ali pija e, ker vas lahko zaduši.
They must not give you any food or drink as it could choke you. lo
Nezdravljena huda hipoglikemija lahko povzro i (prehodno ali trajno) okvaro možganov in celo smrt. ā
If severe hypoglycaemia is not treated, it can cause brain damage (temporary or permanent) and even death no
e doživite hipo, zaradi katere se onesvestite, ali doživljate veliko hip, se posvetujte z ve
If you have a hypo that makes you pass out, or a lot of hypos, talk to your doctor.
zdravnikom.
The amount or timing of insulin, food or exercise may need to be adjusted. ct
Morda bo treba prilagoditi koli ino ali as dajanja insulina, hrano ali telesno dejavnost. a m
Using glucagon du
Uporaba glukagona ni
You may recover more quickly from unconsciousness with an injection of the hormone glucagon by ro
Iz nezavesti se boste morda zbudili prej, e dobite injekcijo hormona glukagona; dati jo mora oseba, ki ga zna uporabljati. e dobite glukagon, boste potrebovali glukozo ali sladek prigrizek, takoj ko se lo
If you are given glucagon you will need glucose or a sugary snack as soon as you are conscious.
zaveste. e se ne odzovete na zdravljenje z glukagonom, bo potrebno zdravljenje v bolnišnici.
If you do not respond to glucagon treatment, you will have to be treated lp
Po injekciji glukagona poiš ite zdravniško pomo: ugotoviti morate razlog za hipo, da jih ne boste vi
in a hospital.
doživeli še ve. ra
Causes of a hypo ic
Vzroki za hipe Zd
• If you take too much insulin • If you eat too little or miss a meal M
To se lahko zgodi, e: • uporabite preve insulina, • premalo jeste ali izpustite obrok, • ste telesno bolj dejavni kot ponavadi.
• If you exercise more than usual.
e se vam sladkor v krvi preve zviša
If your blood sugar gets too high
Sladkor v krvi se vam lahko preve zviša (to imenujemo hiperglikemija).
The warning signs appear gradually.
24 Opozorilni znaki se pojavijo postopoma.
If you get any of these signs, test your blood sugar level and test your urine for ketones if you can.
Med njimi so: pove ano uriniranje, ob utek žeje, izguba apetita, ob utek slabosti (slabost ali bruhanje), ob utek zaspanosti ali utrujenosti, pordela, suha koža, suha usta in zadah z vonjem po sadju (acetonu). e se pojavi kateri od teh znakov, si izmerite sladkor v krvi in dolo ite ketone v urinu, e imate to možnost.
Then seek medical advice straight away.
Potem takoj poiš ite zdravniški nasvet.
These may be signs of a very serious condition called diabetic ketoacidosis.
To so lahko znaki zelo resnega stanja, ki ga imenujemo diabeti na ketoacidoza. e ga ne zdravite, lahko povzro i diabeti no komo in smrt.
If you don’ t treat it, this could lead to diabetic coma and death.
Vzroki za hiperglikemijo • Pozabili ste si dati insulin. • Ve krat zapored ste uporabili manj insulina, kot ga potrebujete. • Imate okužbo ali zvišano telesno temperaturo.
25 Causes of hyperglycaemia
et • Jeste ve kot ponavadi.
• Having forgotten to take your insulin • Repeatedly taking less insulin than you need • An infection or a fever • Eating more than usual • Less exercise than usual.
m • Ste manj telesno dejavni kot ponavadi.
ed Like all medicines, Velosulin can cause side effects, although not everybody gets them.
za Kot vsa zdravila ima lahko tudi zdravilo Velosulin neželene u inke, ki pa se ne pojavijo pri vseh bolnikih.
is Side effects reported uncommonly (in less than 1 patient in 100)
a nj Ob asno opisani neželeni u inki (pri manj kot 1 bolniku na 100) lje Težave z vidom.
When you first start your treatment, it may disturb your vision, but the reaction
Ko za nete prvi uporabljati zdravilo, lahko povzro i motnje vida, ki pa ponavadi izginejo. vo
th usually disappears.
Spremembe na mestu injiciranja (lipodistrofija). e insulin prepogosto injicirate na isto mesto, se do
au Changes at the injection site (Lipodystrophy).
lahko podkožno maš evje na tem mestu skr i (lipoatrofija) ali zadebeli (lipohipertrofija).
Changing the
injiciranja opazite ugreznjenost ali izbo enost kože, morate to povedati zdravniku ali diabetološki ve
er site with each injection may help to prevent such skin changes.
medicinski sestri.
If you notice your skin pitting or thickening at the injection site, tell your doctor or diabetes nurse because these reactions can become ng more severe, or they may change the absorption of your insulin if you inject in such a site. lo
Takšne reakcije namre lahko postanejo hujše ali spremenijo absorpcijo insulina, e ga injicirate na takšno mesto. a
Reactions (redness, swelling, itching) at the injection site may occur (local allergic reactions).
Pojavijo se lahko reakcije (pordelost, oteklina, srbenje) na mestu injiciranja (lokalne m
These usually disappear after a few weeks of taking your insulin.
alergijske reakcije).
If they do not disappear, no
Ponavadi minejo po nekaj tednih uporabe insulina. e ne minejo, pojdite k zdravniku. ni
Seek medical advice immediately: • if signs of allergy spread to other parts of the body, or ct
Nemudoma poiš ite zdravniško pomo, e: • se znaki alergije razširijo na druge dele telesa ali lo
• if you suddenly feel unwell and you start sweating; start being sick (vomiting); have difficulty du
• se nenadoma slabo po utite in se za nete znojiti, vam postane slabo (bruhate), imate težave z vi
in breathing; have a rapid heart beat; feel dizzy; feel like fainting.
dihanjem, vam srce hitro bije, ste omoti ni, utite omedlevico.
You may have a very rare serious allergic reaction to Velosulin or one of its ingredients (called a ro
Morda imate zelo redko, resno alergijsko reakcijo na Velosulin ali eno njegovih sestavin (to ra
systemic allergic reaction).
imenujemo sistemska alergijska reakcija).
See also warning in 2 Before you use Velosulin. lp
Kaj morate vedeti, Zd
Painful neuropathy (nerve related pain).
preden boste uporabili Velosulin.
If a
Pojav imenujemo akutna bole a nevropatija in ponavadi izgine. e ne izgine, pojdite k zdravniku.
When you start taking insulin, water retention may cause swelling around your ankles ic
Ko za nete uporabljati insulin, lahko zastajanje vode povzro i otekline okrog gležnjev in drugih sklepov.
and other joints.
To kmalu mine.
Side effects reported very rarely (in less than 1 patient in 10,000) M
25 Neželeni u inki, opisani zelo redko (pri manj kot 1 bolniku na 10. 000)
26 6 HOW TO STORE VELOSULIN
SHRANJEVANJE ZDRAVILA VELOSULIN
Do not use Velosulin after the expiry date which is stated on the label and the carton.
m o Zdravila Velosulin ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki
Do not store them in or too near the freezer section or cooling element.
za Ne shranjujte v zamrzovalniku in ne preblizu zamrzovalnika ali hladilnega elementa.
Keep the vials in the original package.
a Viale hranite v originalni ovojnini!
ed The vials that are being used or about to be used is not to be kept in a refrigerator.
nj Viale, ki jih uporabljate ali jih boste pravkar uporabili, ne shranjujte v hladilniku.
The vial may be kept at room
V rezervoarju rpalke lahko imate zdravilo 6 dni pri temperaturi do 37°C (v bližini telesa).
is temperature (not above 25°C) for 6 weeks after first opening.
Vialo lahko shranjujete lje pri sobni temperaturi (do 25 °C) 6 tednov po prvem odprtju.
Always keep the vial in the outer carton when you’ re not using it in order to protect it from light.
Kadar viale ne uporabljate, jo vedno shranjujte v zunanji ovojnini, da bo zaš itena pred svetlobo. vo
or Velosulin must be protected from excessive heat and sunlight.
Velosulin je treba zaš ititi pred ezmerno toploto in son no svetlobo. do
Ask your pharmacist how to
Zdravila Velosulin ne smete odvre i v odpadne vode ali med gospodinjske odpadke.
au dispose of medicines no longer required.
O na inu odstranjevanja zdravila, ki ga ne potrebujete ve, se posvetujte s farmacevtom.
These measures will help to protect the environment.
Takšni ukrepi pomagajo varovati okolje. ā ve
FURTHER INFORMATION ng What Velosulin contains lo
Kaj vsebuje zdravilo Velosulin ni
1 vial contains 10 ml equivalent to 1000 IU no
1 viala vsebuje 10 ml, kar ustreza 1000 i. e. lo
– The other ingredients are zinc chloride, glycerol, metacresol, disodium phosphate dihydrate, sodium hydroxide, hydrochloric acid and water for injections. ct du
– Pomožne snovi so cinkov klorid, glicerol, metakrezol, dinatrijev fosfat dihidrat, natrijev vi
What Velosulin looks like and contents of the pack The solution for injection or infusion comes as a clear, colourless, aqueous solution. ro
hidroksid, klorovodikova kislina in voda za injekcije. ra
Not all packs may be marketed. lp
Opremljena v pakiranjih z 1 ali 5 10- ml vialami ali v pakiranjih z ve vialami, v katerih je 5 x (1 x 10 ml) vial (na trgu lahko ni vseh navedenih pakiranj).
Marketing Authorisation Holder and Manufacturer a
Imetnik dovoljenja za promet z zdravilom in izdelovalec
Novo Allé, DK-2880 Bagsværd, Denmark ic
Novo Nordisk A/ S Novo Allé, DK- 2880 Bagsværd, Danska
This leaflet was last approved in ed M
Navodilo je bilo odobreno:
Ventavis is a solution for inhalation using a nebuliser.
Zdravilo Ventavis je raztopina za inhaliranje s pomočjo nebulatorja.
It contains the active substance iloprost.
Vsebuje zdravilno učinkovino iloprost.
Ventavis is used for the treatment of adult patients with class III primary pulmonary hypertension to improve exercise capacity (the ability to carry out physical activity) and symptoms.
Zdravilo Ventavis se uporablja za zdravljenje odraslih bolnikov s primarno pljučno hipertenzijo funkcijskega razreda III za izboljšanje fizične zmogljivosti (sposobnosti za izvajanje telesne vadbe).
Pulmonary hypertension is abnormally high blood pressure in the arteries of the lungs. ‘ Primary ’ means that there are no other diseases of the heart or lungs causing the high blood pressure, and the ‘ class’ reflects the severity of the symptoms caused by the disease: ‘ class III’ involves marked limitation of physical activity.
„ razred III “ označuje občutno omejitev fizične zmogljivosti.
Because the number of patients with primary pulmonary hypertension is low, the disease is considered ‘ rare’, and Ventavis was designated an ‘ orphan medicine ’ (a medicine used in rare diseases) on 29 December 2000.
Ker je bolnikov s primarno pljučno hipertenzijo majhno, velja bolezen za „ redko “, zato je bilo zdravilo Ventavis dne 29. decembra 2000 določeno kot „ zdravilo sirota “ (zdravilo, ki se uporablja pri redkih boleznih).
Ventavis is given by inhalation using a nebuliser (a special machine that changes the solution into an aerosol that the patient can breathe in).
Ventavis se inhalira s pomočjo nebulatorja (posebne priprave, ki raztopino spremeni v razpršeno meglico, ki jo bolnik lahko vdihava).
Treatment with Ventavis should be started and monitored by a doctor who has experience in the treatment of pulmonary hypertension.
Zdravljenje z zdravilom Ventavis mora uvesti in nadzorovati zdravnik, ki ima izkušnje z zdravljenjem pljučne hipertenzije.
The recommended dose is 2.5 or 5.0 micrograms.
Priporočeni odmerek je 2, 5 ali 5, 0 mikrograma.
Patients should start with the low dose of 2.5 micrograms for the first inhalation, followed by 5.0 micrograms for the second.
Bolniki morajo začeti z nizkim 2, 5- mikrogramskim odmerkom za prvo vdihavanje, čemur sledi 5, 0- mikrogramski odmerek za drugo vdihavanje.
The dose can then be reduced to 2.5 micrograms again if the patient cannot tolerate the higher dose.
Odmerek se lahko nato ponovno zniža na 2, 5 mikrograma, če bolnik višjega odmerka ne prenaša.
The medicine must be given using a type of nebuliser known as a ‘ dosimetric’ nebuliser, which stops automatically when the correct dose has been delivered.
Zdravilo se mora jemati z vrsto nebulatorja, imenovanega „ dozimetrični nebulator “, ki se samodejno ustavi takrat, ko je bil prejet ustrezni odmerek.
It is taken six to nine times a day.
Zdravilo se daje šest - do devetkrat dnevno.
Doses are lower if the patient has liver problems.
Pri bolnikih z obolenji jeter morajo biti odmerki nižji.
Pulmonary hypertension is a debilitating disease where there is severe constriction (narrowing) of the blood vessels of the lungs.
Pljučna hipertenzija je izčrpavajoča bolezen, pri kateri pride do hude konstrikcije (zoženja) krvnih žil v pljučih.
It causes high blood pressure in the vessels taking blood from the right side of the heart to the lungs.
Povzroča visok krvni tlak v žilah, po katerih se pretaka kri iz desne strani srca v pljuča.
Ventavis is an inhaled formulation of iloprost, a substance that is very similar to prostacyclin, a naturally occurring molecule that causes blood vessels to dilate (expand).
Zdravilo Ventavis je inhalacijska formulacija iloprosta, učinkovine, ki je zelo podobna prostaciklinu,
Reproduction is authorised provided the source is acknowledged.
Reproduction is authorised provided the source is acknowledged. naravno prisotni molekuli, ki povzroča dilatacijo (širjenje) krvnih žil.
Ventavis has been compared with placebo (a dummy treatment) in one study involving 203 adult patients with stable class III or IV pulmonary hypertension that was either primary or caused by another condition.
Zdravilo Ventavis so primerjali s placebom (zdravilom brez zdravilne učinkovine) v študiji, v katero so bili vključeni 203 odrasli bolniki s stabilno pljučno hipertenzijo funkcijskega razreda III ali IV, ki je bila bodisi primarna ali pa posledica drugega bolezenskega stanja.
The main measure of effectiveness was the number of patients who had responded to treatment after 12 weeks.
Glavno merilo učinkovitosti je bilo število bolnikov, ki so se po 12. tednih odzvali na zdravljenje.
A ‘ response’ was defined as a combination of a 10% improvement in exercise capacity (measured by looking at how far the patient could walk in six minutes) and an improvement of the patient ’ s condition (the severity of the disease going down by at least one class), without a worsening of pulmonary hypertension or death.
„ Odziv “ je bil opredeljen kot kombinacija 10- odstotnega izboljšanja fizične zmogljivosti (ki je bila izmerjena s proučitvijo dolžine, ki jo je bolnik lahko prehodil po šestih minutah) in izboljšanja stanja (resnost obolenja se je znižala za vsaj en funkcijski razred) brez poslabšanja pljučne hipertenzije ali smrti.
17% of the patients taking Ventavis responded to treatment (17 out of 101), compared with 5% of the patients taking placebo (5 out of 102).
Zdravilo Ventavis je bilo znatno učinkovitejše od placeba: na zdravljenje se je odzvalo 17% bolnikov, ki so jemali zdravilo Ventavis (17 bolnikov od 101), v primerjavi s 5% bolnikov, ki so jemali placebo (5 bolnikov od 102).
However, when looking at different groups of patients in this study, a benefit of Ventavis that would be relevant for patients was only shown in patients with class III primary pulmonary hypertension.
Vendar pa je pri proučevanju različnih skupin bolnikov v tej študiji bila korist zdravila Ventavis, ki bi bila pomembna za bolnike, ugotovljena samo pri bolnikih s primarno pljučno hipertenzijo funkcijskega razreda III.
The most common side effects with Ventavis (seen in more than 1 patient in 10) are vasodilation (blood vessels becoming wider causing flushing or reddening of the face), hypotension (low blood pressure) and cough.
Najpogostejši neželeni učinki zdravila Ventavis (opaženi pri več kot 1 bolniku od 10) so vazodilatacija (razširitev krvnih žil, ki povzroči zardevanje ali rdečico na obrazu), hipotenzija (nizek krvni tlak) in kašelj.
For the full list of all side effects reported with Ventavis, see the Package Leaflet.
Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Ventavis, glejte navodilo za uporabo.
Ventavis should not be used in people who may be hypersensitive (allergic) to iloprost or any of the other ingredients.
Zdravila Ventavis ne smejo uporabljati osebe, ki utegnejo biti preobčutljive za (alergične na) iloprost ali katero koli drugo sestavino zdravila.
It must not be used in patients who are at risk of bleeding, who have certain heart problems, who have recently had a stroke, or whose pulmonary hypertension is caused by a blocked or narrow vein.
Uporabljati se ne sme pri bolnikih, pri katerih obstaja tveganje za krvavitve, osebah, ki imajo težave s srcem, ki so nedavno doživele kap ali imajo pljučno hipertenzijo zaradi zamašene ali zožene žile.
It must also not be used in women who are pregnant or breast-feeding.
Prav tako ga ne smejo uporabljati bolnice, ki so noseče ali dojijo.