natgillin/translations-raw huggingface dataset:
Use of dexmedetomidine as a premedicant in dogs significantly reduces the amount of induction drug required for induction of anaesthesia.
Protiholinergične snovi morate skupaj z deksmedetomidinom uporabljati previdno.
Attention should be given during the administration of intravenous induction drugs to effect.
Uporaba deksmedetomidina za pripravo na kirurške posege pri psih bistveno zmanjša količino indukcijskega zdravila, potrebnega za indukcijo anestezije.
Volatile anaesthetic requirements for maintenance anaesthesia are also reduced.
Med dajanjem intravenskega indukcijskega zdravila do doseženega učinka morate biti pozorni.
Anticholinergics should be used with caution with dexmedetomidine.
Zmanjšana je tudi potreba po hlapnih anestetikih za vzdrževanje anestezije.
After administration of 40 micrograms dexmedetomidine/ kg bw intramuscularly concurrently with 5 mg ketamine / kg bw to cats, the maximum concentration of dexmedetomidine increased twofold but there was no effect on T max.
Po intramuskularni uporabi 40 mikrogramov deksmedetomidina/ kg telesne teže skupaj s 5 mg ketamina/ kg telesne teže se je najvišja koncentracija povečala dvakrat, vendar ni bilo učinka na Tmax.
A dose of 10 mg ketamine/ kg used concurrently with 40 micrograms dexmedetomidine/ kg may cause tachycardia.
Uporaba odmerka 10 mg ketamina/ kg skupaj s 40 mikrogrami deksmedetomidina/ kg lahko povzroči tahihardijo.
22 Administration of atipamezole after dexmedetomidine rapidly reverses the effects and thus shortens the recovery period.
Uporaba atipamezola po deksmedetomidinu hitro obrne učinke in tako skrajša obdobje prenehanja delovanja.
Within 15 minutes dogs are normally awake and standing
Psi so ponavadi budni in stojijo po 15 minutah.
For information on adverse reactions, see section Adverse reactions.
Za dodatne informacije o neželenih učinkih glejte odsek Neželeni učinki.
Equipment for manual ventilation should be available in case of respiratory depression or apnoea when dexmedetomidine and ketamine are used sequentially to induce anaesthesia in cats.
22 Pri zaporedni uporabi deksmedetomidina in ketamina za anestezije pri mačkah lahko pride do dihalnega zastoja ali prenehanja dihanja, zato imejte pri roki opremo za ročno ventilacijo.
In cases of overdosage, or if the effects of dexmedetomidine become potentially life- threatening, the appropriate antagonist is atipamezole, administered by intramuscular injection, at the following dose:
V primeru prevelikega odmerjanja, ali če postanejo učinki deksmedetomidina potencialno nevarni za življenje, uporabite atipamezol v obliki intramuskularne injekcije v naslednjem odmerku:
Persons with known hypersensitivity to the active substance or any of the excipients should administer the product with caution.
Svetujemo uporabo neprepustnih rokavic.
23 13.
23 Med znake absorbcije deksmedetomidina sodijo sedacija, odvisna od odmerka, suha usta ter zmanjšanje krvnega pritiska in hitrosti srčnega utripa.
España Pfizer Salud Animal Tel: +34 91 490 9900
24 Espana Pfizer Salud Animal Tel: +34 91 490 9900
Suomi/ Finland Orion Pharma Eläinlääkkeet Puh/ Tln: +358 (0)10 4261
Suomi/ Finland Orion Pharma Eläinlääkkeet Puh/ Tln: +358 (0) 10 4291
United Kingdom Pfizer Ltd Tel: +44 (0)1304 616161
United Kingdom Pfizer Ltd Tel: +44 (0) 1304 646161
It is available as an oral solution for chickens and turkeys (100 mg/ ml), as tablets for dogs (15 mg, 50 mg, 100 mg and 150 mg), and as a solution for injection for cattle and dogs (50 mg/ ml).
Na voljo je v obliki peroralne raztopine za piščance in purane (100 mg/ ml), v obliki tablet za pse (15 mg, 50 mg, 100 mg in 150 mg) in kot raztopina za injiciranje za govedo in pse (50 mg/ ml).
Dicural is only used in young turkeys of up to 2 kg body weight.
Zdravilo Dicural se uporablja za zdravljenje okužb, ki jih povzročajo bakterije: • Pri piščancih in puranih se zdravilo Dicural uporablja za zdravljenje nekaterih okužb, ki vplivajo na dihala (pljuča in pljučne mešičke), zdravilo Dicural se uporablja samo pri mladih puranih do 2 kg telesne mase.
For both chickens and turkeys it is given in the drinking water for five days; • in dogs, Dicural is used to treat acute (short-lived) infections of the bladder and to treat pyoderma (a skin infection with a rash and raised lumps).
Tako piščancem kot puranom se daje v pitni vodi pet dni. • Pri psih se zdravilo Dicural uporablja za zdravljenje akutnih (kratkotrajnih) okužb sečnega mehurja in za zdravljenje pioderme (okužba kože z izpuščajem in dvignjenimi bulicami).
On the first day of treatment, it can be given by injection under the skin before switching to the tablets; • in cattle, Dicural is used to treat infections affecting the lungs and breathing (shipping fever and calf pneumonia).
Prvi dan zdravljenja se zdravilo lahko injicira pod kožo, preden se preide na uporabo tablet. • Pri govedu se zdravilo Dicural uporablja za zdravljenje okužb, ki vplivajo na pljuča in dihanje (transportna mrzlica in pljučnica pri teletih).
The active substance in Dicural, difloxacin, belongs to a group of antibiotics called ‘ fluoroquinolones’.
Zdravilna učinkovina zdravila Dicural je difloksacin, ki spada v skupino antibiotikov, imenovanih „ fluorokinoloni “.
Difloxacin works by blocking an enzyme called ‘ DNA gyrase’, which is important in allowing bacteria to make copies of their DNA.
Difloksacin deluje tako, da zavira encim „ DNK giraza “, ki je pomemben, ker bakterijam omogoča, da kopirajo svojo DNK.
In dogs, four main trials looked at the effects of Dicural in treating bladder infections.
V enem od teh preizkušanj so ptice, zdravljene z zdravilom Dicural, primerjali z nezdravljenimi pticami, v drugi pa so zdravilo Dicural primerjali z enrofloksacinom (drugim fluorokinolonom, ki se uporablja v veterinarski medicini).
Reproduction is authorised provided the source is acknowledged. at its effects in treating pyoderma: two compared it with enrofloxacin and one compared it with amoxicillin and clavulanic acid.
Pri psih so v štirih glavnih preskušanjih opazovali učinke zdravila Dicural na zdravljenje okužb sečnega mehurja.
When handling Dicural oral solution for chickens and turkeys, use gloves and a face- protecting device to avoid irritation of the skin or eyes.
Pri ravnanju z zdravilom Dicural v obliki peroralne raztopine za piščance in purane je treba uporabljati rokavice ter zaščitno obrazno masko, da bi se izognili draženju kože ali oči.
The European Commission granted a marketing authorisation valid throughout the European Union, for Dicural to Fort Dodge Animal Health Holland on 16 January 1998.
Evropska komisija je dovoljenje za promet z zdravilom Dicural, veljavno po vsej Evropski uniji, odobrila družbi Fort Dodge Animal Health Holland dne 16. januarja 1998.
The marketing authorisation was renewed on 16 January 2003 and on 16 January 2008.
Dovoljenje za promet z zdravilom je bilo obnovljeno dne 16. januarja 2003 in 16. januarja 2008.
This summary was last updated in October 2008.
Povzetek je bil nazadnje posodobljen 10- 2008.
EU/ 2/ 97/ 003/ 001 Dicural
EU/ 2/ 97/ 003/ 001
100 mg/ ml Oral solution
100 mg/ ml Peroralna raztopina Piščanci in purani V vodo za pitje
100 mg/ ml Oral solution
100 mg/ ml
Chickens and turkeys
Peroralna raztopina
In drinking water
Piščanci in purani
Dogs Dogs
10 tablet
Blister (PVC/ Alu) Blister (PVC/ Alu)
Blister (PVC/ Alu)
10 tablets 20 tablets
10 tablet
Not applicable Not applicable
EU/ 2/ 97/ 003/ 011 Dicural
15 mg 50 mg 50 mg 50 mg 100 mg 100 mg 100 mg 150 mg 150 mg 150 mg
100 mg
Coated tablets Coated tablets Coated tablets Coated tablets Coated tablets Coated tablets Coated tablets Coated tablets Coated tablets Coated tablets
Ni smiselna
Dogs Dogs Dogs Dogs Dogs Dogs Dogs Dogs Dogs Dogs
EU/ 2/ 97/ 003/ 013 Dicural
Oral use Oral use Oral use Oral use Oral use Oral use Oral use Oral use Oral use Oral use
EU/ 2/ 97/ 003/ 014 Dicural
Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu) Blister (PVC/ Alu)
Blister (PVC/ Alu)
100 tablets Not applicable 10 tablets Not applicable 20 tablets Not applicable 100 tablets Not applicable 10 tablets Not applicable 20 tablets Not applicable 100 tablets Not applicable 10 tablets Not applicable 20 tablets Not applicable 100 tablets Not applicable
Ni smiselna.
EU/ 2/ 97/ 003/ 016 Dicural
EU/ 2/ 97/ 003/ 016
1 vial Cattle:
1 viala
46 days Dogs: not applicable
46 dni Psi: ni smiselna
1 vial 46 days
1 viala
Dicural 100 mg/ ml oral solution for chickens and turkeys
Dicural 100 mg/ ml, peroralna raztopina za piščance in purane
For a full list of excipients, see section 6.1
Za celoten seznam pomožnih snovi, glejte poglavje 6. 1
Chickens (broilers and future breeders) Turkeys (young turkeys up to 2 kg body weight)
Piščanci (brojlerji in vzrejne ptice) Purani (mladi purani, težki do 2 kg).
In chickens and turkeys:
Zdravljenje kroničnih respiratornih infekcij pri piščancih in puranih, ki jih povzročajo na difloksacin občutljivi mikroorganizmi:
Dicural oral solution is indicated for treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.
Escherichia coli in Mycoplasma gallisepticum.
Dicural oral solution is also indicated for the treatment of infections caused by Pasteurella multocida.
Pri puranih tudi za zdravljenje infekcij, ki jih povzroča Pasteurella multocida.
4.4 Special warnings for each target species
4. 4 Posebna opozorila
4.5 Special precautions for use
Posebni previdnosti ukrepi za uporabo pri živalih
Special precautions for use in animals Heavy reliance on a single class of antibiotics may result in the induction of resistance in a bacterial population.
2/ 63 Stalna uporaba iste vrste antibiotikov ima lahko za posledico rezistenco mikroorganizmov.
2/ 64 Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due to the potential for cross resistance.
Pri uporabi zdravila brez upoštevanja podatkov, ki so navedeni v povzetku glavnih značilnosti zdravila (SPC) lahko pride do zmanjšanja prevalence bakterijske rezistence na fluorokinolone in zmanjšanja učinkovitosti zdravljenja z drugimi kinoloni zaradi možne navskrižne rezistence.
Special precautions to be taken by the person administering the veterinary medicinal product to animals People with a known hypersensitivity to quinolones should avoid any contact with the product.
Osebe z znano preobčutljivostjo na kinolone naj se izogibajo stiku z zdravilom.
In order to avoid irritation of skin and/ or eyes, use gloves and a face-protecting device when handling this product.
Pri ravnanju z zdravilom nosite osebno zaščitno opremo, ki sestoji iz gumijastih rokavic in zaščitnih očal.
4.6 Adverse reactions (frequency and seriousness)
4. 6 Neželeni učinki (pogostnost in resnost)
Do not use in birds in lay and/ or within 4 weeks before the onset of the laying period.
Ne uporabite pri pticah v obdobju nesnosti in/ ali 4 tedne pred začetkom obdobja nesnosti.
4.8 Interaction with other veterinary medicinal products and other forms of interaction
4. 8 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij
4.9 Amounts to be administered and administration route.
4. 9 Odmerjanje in način uporabe
Dicural oral solution must be administered daily in the drinking water in such a concentration that the dose is 10 mg/ kg bodyweight.
Odmerek znaša 10 mg/ kg telesne mase.
Taking into account the content of difloxacin in the oral solution (10%w/ v), the following calculation should be made to determine the volume (ml) to be added for each 1000 litres of water:
Za pripravo ustrezne koncentracije difloksacina v vodi za pitje (10% V/ V) izračunajte količino ml zdravila za 1000 litrov vode:
number of animals in the house X mean weight of individual animal (kg) X 100 ----------------------------------------------------------------------------------------------------- total water consumption of the house on the previous day (litres)
število živali v hlevu X povprečna masa posamezne živali (kg) X 100 ------------------------------------------------------------------------------------ celotna zadnja dnevna količina vode za pitje (litri)
The medicated drinking water should be prepared freshly each day.
Dnevno naj se pripravi sveža vodo, ki ji primešamo zdravilo.
At concentrations in the water of 0.03% (= 300 ml in 1000 litres) or greater, palatability for turkeys may be affected.
Uporaba 0, 03% koncentracije vodne raztopine (= 300 ml v 1000 litrov) ali večje pri puranih ni smiselna.
4.10 Overdose (symptoms, emergency procedures, antidotes)
4. 10 Preveliko odmerjanje (simptomi, nujni ukrepi, protistrupi) (če so potrebni)
Target animal safety studies in chickens and turkeys demonstrated that, when administered in drinking water at 30 mg/ kg (chickens) or 22 mg/ kg (turkeys) for three times the recommended duration (15 consecutive days), difloxacin hydrochloride appeared to be safe for the birds.
Poskusi pri ciljnih živalskih vrstah so pokazali, da je difloksacinijev klorid v dnevnih predpisanih odmerkih (30 mg/ kg pri piščancih in 22 mg/ kg pri puranih) tudi pri trikrat daljšem dajanju (15 dni) varen za ptice.
Meat and offal (chickens and turkeys):
4. 11 Karenca Meso in organi (piščancev in puranov):
24 hours.
24 ur
Not authorised for use in laying birds producing eggs for human consumption.
3/ 63 Ni dovoljena uporaba pri pticah v obdobju nesnosti, katerih jajca so namenjena za prehrano ljudi.
ATC vet code:
ATC vet oznaka:
Strains of Escherichia coli, Pasteurella multocida, Mycoplasma gallisepticum isolated from broilers and turkeys have been shown to be sensitive to difloxacin.
Escherichia coli, Pasteurella multocida, Mycoplasma gallisepticum.
96%).
Piščanci Pri piščancih se difloksacin po peroralnem dajanju skoraj v celoti resorbira (približno 96%).
It is well distributed in the body (Vd = 4.7 l/ kg) and has a plasma elimination half-life of approximately 7 hours.
Razpolovni čas izločanja iz plazme znaša približno 7 ur.
Following continuous oral dosing with Dicural oral solution at 10 mg/ kg/ day for five consecutive days the mean difloxacin steady state plasma concentrations are approximately 200 ng/ ml.
Pri pet dnevnem dajanju peroralne raztopine Dicural v odmerku 10 mg/ kg/ dan znašajo plezemske koncentracije difloksacina približno 200 µg/ ml.
Tissue to plasma ratios range from 0.6 (abdominal fat), 2.4 (lung), 4.5 (muscle) to 14.1 (liver).
Koncentracije difloksacina v organih so različne in znašajo od 0, 6 v abdominalni maščobi do 2, 4 v pljučih in 14, 1 v jetrih.
58%).
Purani Pri puranih je biološka uporabnost peroralno apliciranega difloksacina približno 58%.
It is very well distributed in the body (Vd = 9.9 l/ kg) and has a plasma elimination half-life of approximately 7 hours.
Razpolovni čas izločanja iz plazme znaša približno 7 ur.
Tissue to plasma ratios range from 2.5 (abdominal fat), 3.7 (muscle), 4.8 (lung) to 36.5 (liver).
Pri pet dnevnem dajanju Dicurala v odmerku 10 mg/ kg/ dan znašajo plezemske koncentracije približno 60 µg/ ml. Koncentracija difloksacina v organih pa so različne in znašajo od 2, 5 v abdominalni maščobi, do 3, 7 v mišicah in 36, 5 v jetrih.
In both species difloxacin may be conjugated (glucuronidated or sulphated), desmethylated into sarafloxacin or oxidised into N-oxide-difloxacin.
Pri obeh vrstah se difloksacin metabolizira v sarafloksacin (desmetil difloksacin) ali pa oksidira v N - oksid- difloksacin.
4/ 64 6.2 Incompatibilities
4/ 63 6. 2 Glavne inkopatibilnosti
No additional chlorine, for example from the use of water chlorinators, or hydrogen peroxide should be added to the drinking water used with this product..
Vodi, v kateri je primešano zdravilo, ne dodajajte klorovih pripravkov (za kloriranje vode) ali vodikovega peroksida.
Shelf life after first opening the container:
Rok uporabnosti po prvem odpiranju neposredne ovojnice:
Do not store above 25 °C.
Shranjujte pri temperaturi do 25˚C.
Protect from light.
Zdravilo ne sme zmrzniti.
Do not freeze.
Ne izpostavljajte svetlobi.
White HDPE bottles with a screw cap containing 250 ml or 1 litre of Dicural oral solution.
Bela steklenica (HDPE) za 250 ml ali 1 liter, zaprta z navojno zaporko.
The screw cap on the 1 litre bottle can be used as a measuring device.
Navojna zaporka pri litrskih steklenicah se lahko uporablja kot merica; napolnjena do roba vsebuje 50 ml.
For the 250 ml bottle a separate measuring device is placed on the screw cap.
Pri 250 ml steklenicah pa je na navojni zaporki priložena posebna merica, na kateri so zareze, ki označujejo potreben volumen.
6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products, if any
6. 6 Posebni varnostni ukrepi za odstranjevanje neporabljenega zdravila ali odpadnih snovi, če obstajajo
EU/ 2/ 97/ 003/ 001-003
EU2/ 97/ 003/ 001- 3
DATE OF RENEWAL OF THE AUTHORISATION
DATUM PRIDOBITVE / PODALJŠANJA DOVOLJENJA ZA PROMET
Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency (EMEA) http: / /www. emea. europa. eu/
{MM/ LLL} Podrobne informacije o tem zdravilu za uporabo v veterinarski medicini so na voljo na spletni strani Evropske agencije za zdravila (European Medicines Agencx, EMEA) http: www. emea. europa. eu /
5/ 64 PROHIBITION OF SALE, SUPPLY AND/ OR USE
5/ 63 PREPOVED PRODAJE, OSKRBE IN/ ALI UPORABE
6/ 64 1.
6/ 63 1.
difloxacin (as hydrochloride) difloxacin (as hydrochloride)
difloksacin (v obliki klorida) 15 mg difloksacin (v obliki klorida) 50 mg difloksacin (v obliki klorida) 100 mg difloksacin (v obliki klorida) 150 mg
For a full list of excipients, see
Pomožne snovi:
section 6.1
Za celoten seznam pomožnih snovi, glejte poglavje 6. 1
Coated tablets
Bikonveksne, kremasto obarvane, filmsko obložene tablete
For the treatment of: • Acute uncomplicated urinary tract infections caused by Escherichia coli or Staphylococcus spp. • Superficial pyoderma caused by Staphylococcus intermedius.
Površinske pioderme, ki jo povzroči Staphylococcus intermedius.
7/ 64 4.5 Special precautions for use
Posebni previdnosti ukrepi za uporabo pri živalih
Special precautions for use in animals Heavy reliance on a single class of antibiotics may result in the induction of resistance in a bacterial population.
7/ 63 Stalna uporaba iste vrste antibiotikov ima lahko za posledico rezistenco mikroorganizmov.
The observed reactions were inappetence, emesis, diarrhoea and anal irritation.
Kažejo se v zmanjšanju apetita, pojavu slabosti, driske in iritacije anusa.
Dicural coated tablets should be given once a day for at least 5 days.
Priporočljiv dnevni odmerek difloksacina znaša 5 mg/ kg telesne mase.
Dogs treated orally with difloxacin (as hydrochloride) at 10 times the recommended dose for 10 days occasionally showed mild adverse reactions such as orange/ yellowing discoloration of the faeces, emesis and hypersalivation.
Psi, ki so dobivali 10 dni zapovrstjo difloksacinijev klorid v 10 krat večjem odmerku od predpisanega, so pokazali rahle znake neželenih učinkov, kot so: rumeno- oranžno obarvanost blata, slabost in povečano slinjenje.
Histopathological changes were noted in the articular cartilage of weight bearing joints of young (3.5 months old) beagle dogs after the oral administration of difloxacin at doses of greater than 5 mg/ kg/ day for 90 days.
Opažene so histopatološke spremembe sklepnega hrustanca pri psih pasme beagle, ki so pri starosti 3, 5 mesecev dobivali peroralno večji odmerek od 5 mg/ kg 90 dni zapovrstjo.
8/ 64 4.11 Withdrawal period
4. 11 Karenca( e)
Pharmacotherapeutic group: general anti-infectives for systemic use; antibacterials for systemic use, quinolone antibacterials.
8/ 63 Farmakoterapevtska skupina: splošni antibiotik za sistemsko uporabo; protimikrobno zdravilo za sistemsko uporabo; kinolonski antibakterik
Difloxacin is an aryl-fluoroquinolone with a broad spectrum of antimicrobial activity.
Difloksacin je aril- fluorokinolon s širokim spektrom protimikrobnega učinkovanja.
Following an oral dose (a plain tablet) in dogs of 5 mg/ kg bodyweight, difloxacin reached its average peak plasma concentration of 1.8 µg/ ml in approximately 3 hours.
Difloksacin po peroralnem dajanju (tableta) v odmerku 5 mg/ kg telesne mase pri psih doseže najvišjo koncentracijo v plazmi 1, 8 µg v 3 urah.
Approximately 95% of the oral dose was absorbed.
Približno 95% peroralnega odmerka se absorbira.
The elimination half-life averaged 9.3 hours.
Razpolovni čas izločanja znaša približno 9, 3 ure.
Long term daily oral treatment over 180 days at 5 mg/ kg bodyweight did not influence difloxacin kinetics, neither by accumulation nor by increased drug metabolism.
Tudi dolgotrajno dajanje zdravila (nad 180 dni) v odmerku 5 mg/ kg telesne mase ni imelo vpliva na kinetiko difloksacina – ne na njegovo akumulacijo in ne na povečanje njegovega metabolizma.
Sodium starch glycollate Microcrystalline cellulose Magnesium stearate Colloidal silicon dioxide Sodium lauryl sulphate Lactose Sodium croscarmellose
Natrijev karboksimetilškrob Mikrokristalna celuloza Magnezijev stearat Silikondioksid, koloidni Natrijev laurilsulfat Laktoza Natrijev karmelozat, premreženi Mikroniziran pivski kvas Aroma jeter
6.2 Incompatibilities
6. 2 Glavne inkopatibilnosti
6.3 Shelf-life
9/ 63 6. 3 Rok uporabnosti
Do not store above 25 °C.
Shranjujte pri temperaturi do 25˚ C.
Store in a dry place.
Shranjujte na suhem mestu
6.5 Nature and contents of container
6. 5 Vrsta vsebnika
PVC/ aluminium blisters with 10 tablets per blister.
PVC/ aluminijast blister z 10 filmsko obloženimi tabletami.
6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products, if any
6. 6 Posebni varnostni ukrepi za odstranjevanje neporabljenega zdravila ali odpadnih snovi, če obstajajo Vsako neporabljeno zdravilo ali odpadne snovi, ki nastanejo iz teh zdravil, je treba odstraniti v skladu z lokalnimi predpisi.
EU/ 2/ 97/ 003/ 004-015
EU2/ 97/ 003/ 004- 015
Dicural 50 mg/ ml solution for injection for cattle and dogs
Dicural 50 mg/ ml, raztopina za injiciranje za govedo in pse
Cattle (calves and young cattle) Dogs
Govedo (teleta in mlado govedo) Psi
In cattle:
Govedo:
Dicural 50 mg/ ml solution for injection is indicated for the treatment of bovine respiratory disease (shipping fever, calf pneumonia) caused by single or mixed infections with Pasteurella haemolytica, Pasteurella multocida, and/ or Mycoplasma spp.
Pasteurella haemolytica, Pasteurella multocida in/ ali Mycoplasma spp.
Dicural 50 mg/ ml solution for injection is indicated for the treatment of: • Acute uncomplicated urinary tract infections caused by Escherichia coli or Staphylococcus spp • Superficial pyoderma caused by Staphylococcus intermedius.
Površinske pioderme, ki jo povzroča Staphylococcus intermedius.
Therefore, do not use in small and medium-sized breeds of dogs up to and including 8 months of age, in large breeds up to 1 year of age and in giant breeds up to 18 months of age.
Tako kot drugi fluorokinoloni tudi difloksacin učinkuje zaviralno na rast in obnavljanje sklepnega hrustanca, zato ga ne uporabite pri psih v fazi hitre rasti, ki je pri majhnih in srednje velikih pasmah psov do 8. meseca starosti, pri večjih pasmah do 1 leta, pri izredno velikih pasmah psov pa do 18. meseca starosti.
4.4 Special warnings for each target species
11/ 63 4. 4 Posebna opozorila za vsako ciljno živalsko vrsto
11/ 64 4.5 Special precautions for use
Posebni previdnosti ukrepi za uporabo pri živalih
Special precautions for use in animals Heavy reliance on a single class of antibiotics may result in the induction of resistance in a bacterial population.
Stalna uporaba iste vrste antibiotikov ima lahko za posledico rezistenco mikroorganizmov.
Official and local antimicrobial policies should be taken into account when the product is used.
Pri uporabi zdravila brez upoštevanja podatkov, ki so navedeni v povzetku glavnih značilnosti zdravila (SPC) lahko pride do zmanjšanja prevalence bakterijske rezistence na fluorokinolone in zmanjšanja učinkovitosti zdravljenja z drugimi kinoloni zaradi možne navskrižne rezistence.