natgillin/translations-raw huggingface dataset:
The Ciprofloxacin Bayer 100 mg/ mL oral suspension is indicated for the treatment of the following infections (see sections 4.4 and 5.1).
Zdravilo Ciprofloksacin Bayer 100 mg/ ml zrnca in vehikel za peroralno suspenzijo se uporablja za zdravljenje naslednjih okužb (glejte poglavji 4. 4 in 5. 1)..
• Infections of the skin and soft tissue caused by Gram-negative bacteria
152 • okužbe kože in mehkih tkiv, ki jih povzročajo po Gramu negativne bakterije
149 • Malignant external otitis
• maligno vnetje zunanjega ušesa
(Number of 5-mL
dnevni odmerki (ml) (število 5- ml merilnih žličk)
5 mL twice daily to
5 – 7, 5 ml
(one 5-mL measuring spoonful twice daily up to one and a half 5- mL measuring spoonfuls twice daily)
dvakrat na dan (ena do ena in pol 5- ml merilna
Daily dose in mg
žlička dvakrat na
Daily dose in mL
153 indikacije
(Number of 5-mL
dnevni odmerki (ml) (število 5- ml merilnih žličk) dan)
5 mL twice daily to
5 – 7, 5 ml dvakrat na dan (ena do ena in pol 5- ml merilna žlička dvakrat na dan)
tract up to one and a half 5- mL measuring spoonfuls twice daily)
5 – 7, 5 ml dvakrat na dan (ena do ena in pol 5- ml merilna žlička dvakrat na dan)
(one 5-mL measuring spoonful twice daily
maligno vnetje zunanjega ušesa
7.5 mL twice daily
dvakrat na 7, 5 ml dan
28 days up to 3
dvakrat na 28 dni do 3 mesecev dan (ena in pol 5- ml merilna
(one and a half 5-mL measuring spoonfuls twice daily)
žlička dvakrat na dan) okužbe sečil
Urinary tract
nezapleten
250 mg twice
250 mg do 500 mg
2.5 mL twice daily to
2, 5 – 5 ml
cystitis
cistitis
daily to 500 mg
dvakrat na dan
(half 5-mL measuring spoonful twice daily up to one 5-mL measuring spoonful twice daily)
dvakrat na dan (pol do ena 5- ml merilna
In pre-menopausal women, 500 mg single dose may be used corresponding to 5 mL single dose = one 5-mL measuring spoonful as a single dose
žlička dvakrat na dan) Pri ženskah v premenopavzi se lahko uporabi 500 mg enkrat na dan (ustreza 5 ml enkrat na dan = ena 5- ml merilna žlička enkrat na dan)
7 days
ml dvakrat na 7 dni dan (ena 5- ml merilna
(one 5-mL measuring spoonful twice daily)
žlička dvakrat na dan)
Complicated
zapleten
at least 10 days, it can
najmanj 10 dni, v
pyelonephritis
pielonefritis
(one 5-mL measuring spoonful twice daily up to one and a half 5- mL measuring spoonfuls twice daily)
dvakrat na dan (ena do ena in pol 5- ml merilna žlička dvakrat na dan)
longer than 21 days in some specific circumstances (such as abscesses)
posebnih primerih je lahko podaljšano za več kot 21 dni (npr. absces)
Prostatitis
154 indikacije
2 to 4 weeks (acute)
dnevni odmerki (ml) (število 5- ml merilnih žličk)
(one 5-mL measuring spoonful twice daily up to one and a half 5- mL measuring spoonfuls twice daily)
skupno trajanje zdravljenja (lahko vključuje tudi začetno parenteralno zdravljenje s ciprofloksacinom)
(chronic)
prostatitis
Daily dose in mg
500 mg do 750 mg dvakrat na dan
(Number of 5-mL
5 – 7, 5 ml dvakrat na dan (ena do ena in pol 5- ml merilna žlička dvakrat na dan)
measuring spoonfuls)
2 do 4 tednov (akutni) do 4 do 6 tednov (kronični)
(potentially
okužbe spolovil
5 mL as a single dose corresponding to one 5-mL measuring spoonful as a single dose
5 ml dvakrat na dan (ena 5- ml merilna žlička dvakrat na dan)
Epididymo-
epididimo - orhitis in medenična vnetna bolezen
(one 5-mL measuring spoonful twice daily up to one and a half 5- mL measuring spoonfuls twice daily)
driska, ki jo povzročajo bakterije, tudi iz vrste Shigella spp., ne pa Shigella dysenteriae tipa 1 in empirično zdravljenje hude potovalne driske
5 mL twice daily
5 ml dvakrat na dan (ena 5- ml merilna žlička dvakrat na dan)
5 mL twice daily (one 5-mL measuring spoonful twice daily)
5 ml dvakrat na dan (ena 5- ml merilna žlička dvakrat na dan)
Typhoid fever
155 indikacije
Intra-abdominal
intraabdominal ne okužbe, ki jih povzročajo po Gramu negative bakterije
Daily dose in mL
okužbe kože in mehkih tkiv
Bone and joint infections
žlička dvakrat na dan) okužbe kosti in sklepov
Treatment of infections or
zdravljenje okužb ali
Therapy should be
zdravljenje je treba
prophylaxis of infections in
preprečevanje okužb pri bolnikih z nevtropenijo; ciprofloksacin je treba dati hkrati z ustreznim antibakterijskim
7.5 mL twice daily
dvakrat na dan (ena do ena in pol 5- ml merilna
continued over the
nadaljevati ves čas nevtropenije
neutropenic patients Ciprofloxacin should be co- administered with appropriate antibacterial agent(s) in accordance to official guidance.
zdravilom( i) v skladu z veljavnimi smernicami
twice daily
žlička
entire period of neutropenia
dvakrat na dan)
5 mL as a single dose corresponding to one 5-mL measuring spoonful as a single dose
5 ml
Inhalation anthrax post-exposure prophylaxis and curative treatment for persons able to receive treatment by oral route when clinically appropriate.
5- ml merilna žlička enkrat na dan) inhalacijski vranični prisad (zaščita in zdravljenje po izpostavitvi povzročitelju) pri osebah, ki se
5 mL twice daily (one 5-mL measuring spoonful twice daily)
5 ml dvakrat na dan (ena
Children and adolescents
5- ml merilna žlička dvakrat na dan)
Indications
156 Otroci in mladostniki
Daily dose in mg and in mL
indikacije
Total duration of
dnevni odmerki (mg in ml)
20 mg/ kg body weight twice daily with a maximum of 750 mg per dose, corresponding to a 0.2 mL/ kg body weight twice daily with a maximum of 7.5 mL per dose
20 mg/ kg telesne mase dvakrat na dan; največ 750 mg na odmerek kar odgovarja 0, 2 ml/ kg telesne mase dvakrat na dan; največ 7, 5 ml na odmerek
10 mg/ kg body weight twice daily to 20 mg/ kg body weight twice daily with a maximum of 750 mg per dose, corresponding to a 0.1 mL/ kg body weight twice daily to 0.2 mL/ kg body weight twice daily with a maximum of 7.5 mL per dose
10 mg/ kg do 20 mg/ kg telesne mase dvakrat na dan; največ 750 mg na odmerek kar odgovarja 0, 1 ml/ kg telesne mase dvakrat na dan do 0, 2 ml/ kg telesne mase dvakrat na dan; največ 7, 5 ml na odmerek
10 mg/ kg body weight twice daily to 15 mg/ kg body
10 mg/ kg do 15 mg/ kg telesne mase dvakrat na dan; največ 500 mg na odmerek kar odgovarja 0, 1 ml/ kg telesne mase dvakrat na dan do 0, 15 ml/ kg telesne mase dvakrat na dan; največ 5 ml na odmerek
days from the
druge hude okužbe
weight twice daily with a maximum of 500 mg per dose, corresponding to a 0.1 mL/ kg body weight twice daily to 0.15 mL/ kg body weight twice daily with a maximum of 5 mL per dose
20 mg/ kg telesne mase dvakrat na dan; največ 750 mg na odmerek kar odgovarja 0, 2 ml/ kg telesne mase dvakrat na dan; največ 7, 5 ml na odmerek
Other severe infections
odvisno od vrste okužbe
According to the type of infections
Otroci in mladostniki
Geriatric patients should receive a dose selected according to the severity of the infection and the patient’ s creatinine clearance.
Starejšim bolnikom se daje glede na resnost bolezni in očistek kreatinina najmanjši možni odmerek zdravila.
154 Method of administration
Način uporabe
Oral suspension can be taken independent of mealtimes.
Peroralno suspenzijo se zaužije ne glede na obroke hrane.
½ measuring spoonful (approx 2.5 mL suspension) provides approx.
2, 5 ml suspenzije) ustreza pribl.
250 mg ciprofloxacin.
125 mg ciprofloksacina.
1 measuring spoonful (approx 5.0 mL suspension) provides approx.
5, 0 ml suspenzije) ustreza pribl.
500 mg ciprofloxacin.
250 mg ciprofloksacina.
• Hypersensitivity to the active substance, to other quinolones or to any of the excipients (see section 6.1).
– preobčutljivost za zdravilno učinkovino, druge kinolone ali katerokoli pomožno snov (glejte poglavje 6. 1)
• Concomitant administration of ciprofloxacin and tizanidine (see section 4.5).
– sočasna uporaba ciprofloksacina in tizanidina (glejte poglavje 4. 5)
Genital tract infections Epididymo-orchitis and pelvic inflammatory diseases may be caused by fluoroquinolone-resistant Neisseria gonorrhoeae.
158 Epididimo- orhitis in medenično vnetno bolezen lahko povzroča za fluorokinolone odporna Neisseria gonorrhoeae.
155 Infections of the bones and joints Ciprofloxacin should be used in combination with other antimicrobial agents depending on the results of the microbiological documentation.
Okužbe kosti in sklepov Ciprofloksacin je treba uporabljati v kombinaciji z drugimi antibakterijskimi zdravili, odvisno od mikrobioloških izvidov.
Hypersensitivity Hypersensitivity and allergic reactions, including anaphylaxis and anaphylactoid reactions, may occur following a single dose (see section 4.8) and may be life-threatening.
159 Preobčutljivostne reakcije V nekaterih primerih se preobčutljivostne in alergijske reakcije, tudi anafilaksa in anafilaktoidne reakcije pojavijo že po prvem odmerku ciprofloksacina (glejte poglavje 4. 8) in so lahko življenjsko ogrožujoče.
156 Tendinitis and tendon rupture (especially Achilles tendon), sometimes bilateral, may occur with ciprofloxacin, as soon as the first 48 hours of treatment.
Včasih se lahko po zdravljenju s ciprofloksacinom (v prvih 48 urah zdravljenja) pojavi tendinitis ali ruptura kite (predvsem Ahilove tetive), včasih obojestransko.
Glucose-6-phosphate dehydrogenase deficiency Haemolytic reactions have been reported with ciprofloxacin in patients with glucose-6-phosphate dehydrogenase deficiency.
160 Pomanjkanje glukoza– 6– fosfat dehidrogenaze Pri bolnikih s pomanjkanjem glukoza– 6– fosfat dehidrogenaze, ki so prejemali ciprofloksacin, so poročali o hemolitičnih reakcijah.
157 Cytochrome P450 Ciprofloxacin inhibits CYP1A2 and thus may cause increased serum concentration of concomitantly administered substances metabolised by this enzyme (e. g. theophylline, clozapine, ropinirole, tizanidine).
Citokrom P450 Ciprofloksacin zavira encimski sistem CYP1A2, kar lahko povzroči zvišanje serumskih koncentracij sočasno danih zdravil, ki se presnavljajo s pomočjo tega encima (npr. teofilin, klozapin, ropinirol, tizanidin).
As Ciprofloxacin Bayer 100 mg/ mL suspension contains 1.3 g sucrose per 5-mL measuring spoonful, this has to be taken into consideration in terms of daily intake.
As Ciprofloxacin Bayer 100 mg/ mL suspension contains 1. 3 g sucrose per 5- mL measuring spoonful, this has to be taken into consideration in terms of daily intake.
Probenecid interferes with renal secretion of ciprofloxacin.
161 Probenecid ovira izločanje ciprofloksacina skozi ledvice.
158 Methotrexate
Metotreksat
It is recommended that the INR should be monitored frequently during and shortly after co-administration of ciprofloxacin with an oral anti- coagulant agent.
Med zdravljenjem in kmalu po sočasni uporabi ciprofloksacina in peroralnega antikoagulanta je treba pogosteje določati vrednosti INR.
Clozapine
162 Klozapin
In juvenile and prenatal animals exposed to quinolones, effects on immature cartilage have been observed, thus, it cannot be excluded that the 159 drug could cause damage to articular cartilage in the human immature organism / foetus (see section 5.3).
Pri mladih in prenatalnih živalih, ki so bile izpostavljene kinolonom, so opažali učinke na nerazvitem hrustancu, zato se možnosti poškodb sklepnega hrustanca pri nerazvitih organizmih/ fetusih ne da zanesljivo izključiti (glejte poglavje 5. 3).
≥ 1/ 1 000 to <
≥ 1/ 10. 000 do <
≥ 1/ 10 000 to <
< 1/ 10
< 1/ 10 000
1/ 1. 000
not known
Občasni
Infections and Infestations
anafilaktični
Mycotic superinfections
edem/ angioedem
Antibiotic associated colitis (very rarely with possible fatal outcome) (see section 4.4)
šok (smrtno nevaren) (glejte poglavje 4. 4) reakcija, podobna serumski bolezni
Blood and Lymphatic System Disorders
Presnovne in prehranske motnje
Eosinophilia
psihomotorič
Leukopenia Anaemia Neutropenia Leukocytosis Thrombocytopenia Thrombocytaemia
anksiozna reakcija nočne more depresija halucinacije
Haemolytic anaemia Agranulocytosis Pancytopenia (life- threatening) Bone marrow depression (life- threatening)
hipoestezija tremor krči (glejte poglavje 4. 4) vrtoglavica
Immune System Disorders
(glejte poglavje 4. 4)
Allergic reaction Allergic oedema / angiooedema
Očesne bolezni Ušesne bolezni, vključno z motnjami labirinta
Anaphylactic reaction Anaphylactic shock (life- threatening) (see section 4.4) Serum sickness- like reaction
motnje vida zvonjenje v ušesih oglušitev/ motnje sluha
Metabolism and Nutrition Disorders
motnje zaznavanja barv
Anorexia
Srčne bolezni
Hyperglycaemia
tahikardija
160 System Organ
Žilne bolezni
Common
vaskulitis
< 1/ 10 000
oceniti iz
not known
Bolezni dihal, prsnega koša in mediastinal nega prostora
1/ 1 000
1/ 1. 000 dispneja (tudi astmatsko stanje)
Psychiatric Disorders
pankreatitis
Psychomotor hyperactivity / agitation
bolečine v trebuhu dispepsija flatulenca
Confusion and disorientation Anxiety reaction Abnormal dreams Depression Hallucinations
prehodno
Psychotic reactions (see section 4.4)
jetrna okvara
Nervous System Disorders
jetrna nekroza
Headache Dizziness Sleep disorders Taste disorders
jeter,
Par- and Dysaesthesia Hypoaesthesia Tremor Seizures (see section 4.4) Vertigo
zvišanje
Migraine Disturbed coordination Gait disturbance Olfactory nerve disorders Intracranial hypertension
holestatski
Peripheral neuropathy (see section 4.4)
(zelo redko
Eye Disorders Ear and Labyrinth Disorders
žolčnika in
Visual disturbances Tinnitus Hearing loss / Hearing impaired
napreduje v
Visual colour distortions
žolčevodov
Cardiac Disorders
transaminaz
Tachycardia
hepatitis
Ventricular arrhythmia, QT prolongation, torsades de pointes *
zvišanje vrednosti bilirubina
Vascular Disorders
nevarno jetrno odpoved)
Vasodilatation Hypotension Syncope
fotosenzitivne
Vasculitis
petehije
Respiratory, Thoracic and Mediastinal Disorders
srbenje
Dyspnoea (including asthmatic condition)
reakcije (glejte
Gastrointestinal Disorders
koprivnica
Nausea Diarrhoea
poglavje 4. 4)
Vomiting Gastrointestinal and abdominal pains Dyspepsia Flatulence
multiforme minor Erythema nodosum Stevens - Johnsonov sindrom (lahko smrtno nevaren) toksična epidermalna nekroliza (lahko smrtno nevarna)
Pancreatitis
skeletnega
Hepatobiliary Disorders
tendinitis
Increase in transaminases Increased bilirubin
sistema in
Hepatic impairment Cholestatic icterus Hepatitis
hrbtu, prsnem košu) artralgija
Liver necrosis (very rarely progressing to life-threatening hepatic failure) (see section 4.4)
Ahilove tetive) (glejte poglavje 4. 4) poslabšanje miastenije gravis (glejte poglavje 4. 4)
161 System Organ
Bolezni sečil
Common
ledvična
Uncommon
165 Organski
Rash Pruritus Urticaria
okvara
Photosensitivity reactions (see section 4.4)
hematurija kristalurija (glejte poglavje 4. 4) tubulointersticijs ki nefritis
Petechiae Erythema multiforme Erythema nodosum Stevens- Johnson syndrome (potentially life- threatening) Toxic epidermal necrolysis (potentially life- threatening)
Splošne
Musculoskeletal, Connective Tissue and Bone Disorders
astenija
Musculoskeletal pain (e. g. extremity pain, back pain, chest pain) Arthralgia
edem
Myalgia Arthritis Increased muscle tone and cramping
težave in
Muscular weakness Tendinitis Tendon rupture (predominantly Achilles tendon) (see section 4.4) Exacerbation of symptoms of myasthenia gravis (see section 4.4)
zvišana
Renal and Urinary Disorders
znojenje (hiper -
Renal impairment
spremembe na mestu aplikacije
Renal failure Haematuria Crystalluria (see section 4.4) Tubulointerstitial nephritis
telesna temperatura
General Disorders and Administration Site Conditions
hidroza)
Asthenia Fever
Preiskave
Oedema Sweating (hyperhidrosis)
zvišanje
162 An overdose of 12 g has been reported to lead to mild symptoms of toxicity.
Prekomerni odmerek 12 g je povzročil blage simptome toksičnosti.
PK/ PD relationship:
166 Razmerje farmokokinetike/ farmoakodinamike
Microorganisms
mikroorganizem
Enterobacteria Pseudomonas
Enterobacteria Pseudomonas Acinetobacter
R > 1 mg/ L R > 1 mg/ L
1
1
S < 0, 5 mg/ l S < 0, 5 mg/ l S < 1 mg/ l
R > 1 mg/ L
R > 1 mg/ l R > 1 mg/ l R > 1 mg/ l
R > 0.06 mg/ L R > 0.06 mg/ L R > 1 mg/ L
R > 0, 5 mg/ l R > 0, 06 mg/ l R > 0, 06 mg/ l R > 1 mg/ l
Groupings of relevant species according to ciprofloxacin susceptibility (for Streptococcus species see section 4.4)
167 Specifične vrste bakterij razvrščenih glede na občutljivost za ciprofloksacin (za streptokoke glejte poglavje 4. 4).
Pseudomonas aeruginosa* Pseudomonas fluorescens Serratia marcescens* Anaerobic micro-organisms Peptostreptococcus spp.
168 anaerobni mikroorganizmi Peptostreptococcus spp.
165 Following oral administration of single doses of 250 mg, 500 mg, and 750 mg of ciprofloxacin tablets, ciprofloxacin is absorbed rapidly and extensively, mainly from the small intestine, reaching maximum serum concentrations 1-2 hours later.
Najvišja serumska koncentracija je dosežena eno do dve uri po zaužitju zdravila.
166 In 10 children with severe sepsis Cmax was 6.1 mg/ L (range 4.6-8.3 mg/ L) after a 1-hour intravenous infusion of 10 mg/ kg in children aged less than 1 year compared to 7.2 mg/ L (range 4.7-11.8 mg/ L) for children between 1 and 5 years of age.
Pri desetih otrocih s hudo sepso, mlajših od enega leta, je bila po 60- minutnem intravenskem infundiranju odmerka 10 mg/ kg, Cmax 6, 1 mg/ l (med 4, 6 in 8, 3 mg/ l); pri otrocih v starosti od 1 do 5 let je bila Cmax 7, 2 mg/ l (med 4, 7 in 11, 8 mg/ l).
Articular tolerability:
170 Vplivi zdravila na sklepe:
167 Press down according to instructions on the cap while turning to the left.
Zaporko pritisnite navzdol glede na navodilo na zaporki in jo hkrati zavrtite v levo.
The graduated measuring spoon with the markings 1/ 2 is equivalent to 2.6 mL containing 2.5 mL of final suspension and 1/ 1 is equivalent to 5.2 mL containing 5.0 mL of final suspension.
Graduirana merilna žlička z oznako ½ ustreza 2, 6 ml in vsebuje 2, 5 ml pripravljene suspenzije in z oznako 1 ustreza 5, 2 ml in vsebuje 5 ml pripravljene suspenzije.
The graduated measuring spoon must be used for measuring the required prescribed amount of Ciprofloxacin oral suspension 100 mg/ mL.
Graduirano merilno žličko je treba uporabiti za odmerjanje zahtevane predpisane količine 10% peroralne suspenzije ciprofloksacina.
[See Annex I - To be completed nationally.]
171 [Glejte Dodatek I – Izpolni država članica]
168 1.
172 1.
Ciprofloxacin Bayer and associated names (see Annex I) 200 mg/ 100 mL solution for infusion [See Annex I - To be completed nationally]
Ciprofloksacin Bayer in povezana imena (Glejte Dodatek I) 200 mg/ 100 ml raztopina za infundiranje [Glejte Dodatek I – Izpolni država članica]
[To be completed nationally]
raztopina za infundiranje [Izpolni država članica]
Ciprofloxacin Bayer 200 mg/ 100 mL solution for infusion is indicated for the treatment of the following infections (see sections 4.4 and 5.1).
Zdravilo Ciprofloksacin Bayer 200 mg/ 100 ml raztopina za infundiranje se uporablja za zdravljenje naslednjih okužb (glejte poglavji 4. 4 in 5. 1).
• Infections of the gastro-intestinal tract (e. g. travellers ` diarrhoea)
• okužbe prebavil (npr. potovalna driska)
• Infections of the skin and soft tissue caused by Gram-negative bacteria
173 • okužbe kože in mehkih tkiv, ki jih povzročajo po Gramu negativne bakterije
• Malignant external otitis
• maligno vnetje zunanjega ušesa
169 • Infections of the bones and joints
• okužbe kosti in sklepov
In severe cases or if the patient is unable to take tablets (e. g. patients on enteral nutrition), it is recommended to commence therapy with intravenous ciprofloxacin until a switch to oral administration is possible.
V hudih primerih ali če bolnik ne more jemati tablet (npr. bolniki na enteralni prehrani), se priporoča zdravljenje z intravenskimi oblikami zdravila, dokler ni možna peroralna uporaba zdravila.
400 mg three times a day
400 mg trikrat na dan
Complicated and
okužbe sečil
uncomplicated pyelonephritis
zapleten in nezapleten pielonefritis
400 mg three times a day
400 mg dvakrat na dan do 400 mg trikrat na dan
continued for longer than 21 days in some specific circumstances (such as abscesses)
7 do 21 dni, v posebnih primerih je lahko podaljšano za več kot 21 dni (npr. absces)
400 mg twice daily 400 mg twice daily to 400 mg three times a day
400 mg dvakrat na dan 400 mg dvakrat na dan do 400 mg trikrat na dan
Treatment of infections or prophylaxis of infections in neutropenic patients Ciprofloxacin should be co-administered with appropriate antibacterial agent(s) in accordance to official guidance.
okužb pri bolnikih z nevtropenijo; ciprofloksacin je treba dati hkrati z ustreznim antibakterijskim zdravilom( i) v skladu z veljavnimi smernicami
400 mg twice daily to 400 mg three times a day
do 400 mg trikrat na dan
Therapy should be continued over the entire period of neutropenia
nadaljevati ves čas nevtropenije
Inhalation anthrax post-exposure prophylaxis and curative treatment for persons requiring parenteral treatment Drug administration should begin as soon as possible after suspected or confirmed exposure.
inhalacijski vranični prisad (zaščita in zdravljenje po izpostavitvi povzročitelju) pri osebah, ki se lahko zdravijo parenteralno, če je to klinično primerno; zdravljenje je treba začeti takoj po domnevni ali potrjeni izpostavitvi povzročitelju.
Indication
indikacije
treatment (including switch to oral therapy as soon as possible) Cystic fibrosis
skupno trajanje zdravljenja (tudi peroralno zdravljenje takoj, ko je možno)
10 mg/ kg body weight three times a day with a maximum of 400 mg per dose.
10 mg/ kg telesne mase trikrat na dan; največ 400 mg na odmerek
6 mg/ kg body weight three times a day to 10 mg/ kg body weight three times a day with a maximum of 400 mg per dose.
6 mg/ kg trikrat na dan do 10 mg/ kg telesne mase trikrat na dan; največ 400 mg na odmerek
Inhalation anthrax
inhalacijski vranični prisad (zaščita in zdravljenje po izpostavitvi povzročitelju) pri osebah, ki potrebujejo parenteralno zdravljenje; zdravljenje je treba začeti takoj po domnevni ali potrjeni izpostavitvi povzročitelju
10 mg/ kg body weight twice daily to 15 mg/ kg body
10 mg/ kg telesne mase dvakrat na dan do 15 mg/ kg telesne mase dvakrat na dan; največ 400 mg na odmerek
Creatinine Clearance [mL/ min/ 1.73 m²]
očistek kreatinina [ml/ min/ 1, 73m²]
Intravenous Dose [mg]
intravenski odmerki [mg]
200-400 mg every 12 h
200 – 400 mg vsakih 12 h 200 – 400 mg / 24 h
200-400 mg every 24 h
na hemodializi
200-400 mg every 24 h (after dialysis)
200 – 400 mg / 24 h (po dializi)
200-400 mg every 24 h
200 – 400 mg vsakih 24 h
Ciprofloxacin Bayer should be checked visually prior to use.
Zdravilo Ciprofloksacin Bayer je treba pred uporabo vizualno preveriti.
172 Ciprofloxacin should be administered by intravenous infusion.
Ciprofloksacin je treba infundirati intravensko.
In adult patients, infusion time is 60 minutes for 400 mg Ciprofloxacin Bayer and 30 minutes for 200 mg Ciprofloxacin Bayer.
30 minut, če se infundira zdravilo Ciprofloksacin Bayer 200 mg/ 100 ml raztopina za infundiranje.
Slow infusion into a large vein will minimise patient discomfort and reduce the risk of venous irritation.
Počasno infundiranje v veliko veno bo zmanjšalo tveganje za vnetje vene, postopek bo za bolnika bolj primeren.
The infusion solution can be infused either directly or after mixing with other compatible infusion solutions (see section 6.2).
Raztopino za infundiranje se lahko infundira neposredno ali v dodatku z drugimi kompatibilnimi raztopinami za infundiranje (glejte poglavje 6. 2).
Hypersensitivity to the active substance, to other quinolones or to any of the excipients (see section 6.1).
• preobčutljivost za zdravilno učinkovino, druge kinolone ali katerokoli pomožno snov (glejte poglavje 6. 1)
Concomitant administration of ciprofloxacin and tizanidine (see section 4.5).
• sočasna uporaba ciprofloksacina in tizanidina (glejte poglavje 4. 5)
Travellers’ diarrhoea The choice of ciprofloxacin should take into account information on resistance to ciprofloxacin in relevant pathogens in the countries visited.
177 Potovalna driska Pri zdravljenju bolnikov s potovalno drisko je potrebno upoštevati podatke o odpornosti povzročiteljev na ciprofloksacin v državah, v katere so potovali.
Treating physicians should refer to national and /or international consensus documents regarding the treatment of anthrax.
Lečeči zdravnik mora upoštevati nacionalne/ mednarodne smernice glede zdravljenja vraničnega prisada.