natgillin/translations-raw huggingface dataset:
What benefit has Advocate shown during the studies?
Kakšne koristi je zdravilo Advocate izkazalo med raziskavami?
The results of the laboratory and field trials in cats and dogs showed that Advocate is effective, when used as detailed in the Package Leaflet (see “ What is Advocate used for? ” above, or for more details see the Package Leaflet).
Rezultati laboratorijskih in terenskih raziskav na mačkah in psih so pokazali, da je zdravilo Advocate učinkovito, če se uporablja v skladu z navedbami iz Navodila za uporabo (glejte „ Za kaj se zdravilo Advocate uporablja? “ zgoraj, za več podrobnosti pa glejte Navodilo za uporabo).
What is the risk associated with Advocate?
Kakšna tveganja so povezana z zdravilom Advocate?
In both cats and dogs the most common side effects are local reactions at the place where the product has been applied, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin.
Tako pri mačkah kot psih so najpogostejši neželeni učinki lokalne reakcije na mestu nanosa zdravila, kot so začasno srbenje, ter poredkoma mastna dlaka in rdečina kože.
Vomiting has also occurred rarely.
Poredkoma je prišlo tudi do bruhanja.
If a cat or dog licks the application area, it might salivate a lot for a short period and then might show signs such as a lack of muscular co-ordination, shaking, abnormal breathing and/ or vomiting.
Če mačka ali pes poliže mesto nanosa, se utegne kratek čas močno sliniti in kazati znake kot so pomanjkljiva mišična koordinacija, tresenje, nenormalno dihanje in/ ali bruhanje.
Dogs and cats weighing less than 1 kg should only be treated after special consideration by the veterinarian.
Pse in mačke, ki tehtajo manj kot 1 kg, je dopustno zdraviti le po posebni presoji veterinarja.
Advocate should not be used in young cats that are under 9 weeks of age.
Zdravila Advocate se ne sme uporabljati pri mladih mačkah, starih manj kot 9 tednov.
Advocate should not be used in young dogs that are under 7 weeks of age.
Zdravila Advocate se ne sme uporabljati pri mladih psih, starih manj kot 7 tednov.
As with other products of this type, Advocate should not be used in sick or ill cats or dogs.
Podobno kot drugih zdravil te vrste, se tudi zdravila Advocate ne sme uporabljati pri bolnih mačkah in psih.
As Advocate comes in different strengths depending on whether it is for use on cats or on dogs, it is very important that the cat products should only be used for cats, and the dog products for dogs.
Ker je zdravilo Advocate na voljo v različnih jakostih, odvisno od tega, ali gre za uporabo pri mačkah ali psih, je zelo pomembno, da se zdravilo za mačke uporablja le za mačke, zdravilo za pse pa le za pse.
Neither product should be used for any other animal species.
Nobenega izmed zdravil ni dopustno uporabljati za nobeno drugo živalsko vrsto.
Advocate has harmful effects on aquatic organisms and so the product should not be allowed to enter ditches, ponds or streams.
Zdravilo Advocate ima škodljive učinke na vodne organizme, zato zdravilo ne sme prispeti v potoke, ribnike ali vodotoke.
Dogs should not be allowed to swim in ditches, ponds or streams for 4 days after treatment.
Psom je treba preprečiti kopanje v potokih, ribnikih ali vodotokih štiri dni po zdravljenju.
The Package Leaflet should be read before use.
Pred uporabo preberite Navodilo za uporabo.
As a precautionary measure, skin contact with the pipette contents should be avoided and animals should not be stroked or groomed until the application site is dry.
Kot previdnostni ukrep je treba preprečiti stik z vsebino pipete, živali pa ni dopustno božati ali negovati dokler se mesto nanosa ne posuši.
When administering Advocate, the user should not smoke, eat or drink, and should wash their hands thoroughly after use.
Med nanašanjem zdravila Advocate naj uporabnik ne kadi, je ali pije, po uporabi pa si naj temeljito umije roke.
If accidental exposure occurs, the eyes should be rinsed with water or the skin washed with soap and water.
Osebe z znano občutljivostjo na benzilalkohol, imidakloprid ali moksidektin naj uporabljajo zdravilo previdno.
The solvent in Advocate may stain certain materials including leather, fabrics, plastics and finished surfaces, so contact between the product and such surfaces should be avoided.
Topilo v zdravilu Advocate lahko pusti madeže na nekaterih materialih, vključno z usnjem, tkaninah, plastiki in lakiranih površinah, zato preprečite stik zdravila s takimi površinami.
Why has Advocate been approved?
Zakaj je bilo zdravilo Advocate odobreno?
The Committee for Medicinal Products for Veterinary Use (CVMP) concluded that the benefits of Advocate exceed the risks for cats and dogs suffering from, or at risk from, mixed parasitic infections, and recommended that Advocate be given a marketing authorisation.
Odbor za zdravila za uporabo v veterinarski medicini (CVMP) je sklenil, da koristi zdravila Advocate pri mačkah in psih, ki imajo ali pri katerih obstaja tveganje za mešane parazitske okužbe, presegajo morebitna tveganja, zato je priporočil, da se za zdravilo Advocate podeli dovoljenje za promet.
Other information about Advocate:
Druge informacije o zdravilu Advocate:
The European Commission granted a marketing authorisation valid throughout the European Union for Advocate to Bayer HealthCare AG (previously called Bayer AG) on 2 April 2003.
Evropska komisija je dovoljenje za promet z zdravilom Advocate, veljavno po vsej Evropski uniji, odobrila družbi Bayer HealthCare AG (prej Bayer AG) dne 2. aprila 2003.
Information on the prescription status of this product may be found on the outer package.
Podatke o predpisovanju tega zdravila najdete na zunanji ovojnini.
This summary was last updated in August 2007.
Povzetek je bil nazadnje posodobljen 08- 2007.
Pharmaceutical Target Route of
Farmacevtska oblika
Packaging
Ciljna živalska vrsta
Package size
Način uporabe Ovojnina zdravila
Withdrawal
Vsebina
Form species administration
Velikost pakiranja
period
Karenca
Advocate Spot-on solution for Small Cats
Advocate, raztopina za kožni nanos za male mačke
10% imidacloprid & 1% moxidectin
10% imidakloprid in 1, 0% moksidektin
Spot-on solution Cats Spot-on use
Kožne kapljice, Mačke raztopina
10% imidacloprid & 2.5% moxidectin
10% imidakloprid in 2, 5% moksidektina
Spot-on solution Dogs Spot-on use
Kožne kapljice, Psi raztopina
EU/ 2/ 03/ 039/ 010
©EMEA 2007 1/ 4 EU/ 2/ 03/ 039/ 010
Advocate Spot-on solution for Extra- Large Dogs
Advocate, raztopina za kožni nanos za zelo velike pse
Advocate Spot-on solution for Medium Dogs
Advocate, raztopina za kožni
10% imidacloprid & 2.5% moxidectin
10% imidakloprid
Pipette (PP) with screw cap (PP)
Polipropilenska pipeta s
Advocate Spot-on solution for Large Dogs
Advocate, 10% raztopina za kožni imidakloprid nanos za velike in 2, 5% pse moksidektina
10% imidacloprid & 2.5% moxidectin
Kožne kapljice, Psi raztopina
Spot-on solution Dogs Spot-on use
Nanos na kožo
Advocate Spot-on solution for Extra- Large Dogs
Advocate, 10% raztopina za kožni imidakloprid nanos za zelo in 2, 5% velike pse moksidektina
Spot-on solution Dogs
Kožne kapljice, Psi raztopina
Spot-on use
Nanos na kožo
Pipette (PP) with screw cap (PP)
Polipropilenska 2, 5 ml pipeta s pokrovom z navojem
Pipette (PP) with screw cap (PP)
Polipropilenska 4 ml pipeta s pokrovom z navojem
Advocate spot-on solution for small cats Advocate spot-on solution for large cats
Advocate, raztopina za kožni nanos za male mačke Advocate, raztopina za kožni nanos za velike mačke
Advocate for cats contains 100 mg/ ml imidacloprid and 10 mg/ ml moxidectin.
100 mg/ ml imidakloprida in 10 mg/ ml moksidektina
Each unit dose (pipette) delivers:
Enota odmerka (pipeta) vsebuje:
Unit Dose
Enota Odmerek
Advocate for small cats (≤ 4 kg) Advocate for large cats (> 4-8 kg)
Advocate za male mačke ≤ 4 kg Advocate za velike mačke ≥ 4 - 8 kg
Benzyl alcohol Butylhydroxytoluene 1 mg/ ml (E 321; as antioxidant).
benzilalkohol 1 mg/ ml butilhidroksitoluena (E 321 kot antioksidant)
Spot-on solution Clear yellow to brownish solution
Kožni nanos, raztopina Bistra, rumena do rjavkasta raztopina
For cats suffering from, or at risk from, mixed parasitic infections:
Za mačke, ki imajo ali so izpostavljene mešanim parazitarnim infestacijam.
For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of ear mite infestation (Otodectes cynotis), prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis) and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara cati and Ancylostoma tubaeforme).
Za uničevanje in zatiranje bolh (Ctenocephalides felis), za zdravljenje ušesnih garij (Otodectes cynotis), za zaščito pred ličinkami Dirofilarie immitis (oblika L3, L4) ter za zdravljenje okužb z želodčno- črevesnimi nematodi (oblika L4, nezrele odrasle in odrasle oblike Toxocara cati in Ancylostma tubaeforme).
Do not use in the case of hypersensitivity to the active substances or to any of the excipients.
Zdravila ne dajemo živalim, ki so občutljive za zdravilne učinkovine ali katerokoli pomožno snov.
For dogs, the corresponding “ Advocate for dog ” product, which contains 100 mg/ ml imidacloprid and 25 mg/ ml moxidectin, must be used.
Pri psih uporabljamo ustrezno obliko zdravila Advocate za pse, ki vsebuje 100 mg/ ml imidakloprida in 25 mg/ ml moksidektina.
2 4.4 Special warnings
2 4. 4 Posebna opozorila
Please refer to section 4.5.
Glej odstavek 4. 5.
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
Vsi zajedavci lahko razvijejo odpornost zoper isto vrsto protizajedavskih pripravkov, ki jih često uporabljamo.
The treatment of animals weighing less than 1 kg should be based on a risk-benefit assessment.
Pri živalih, lažjih od 1 kg, je potrebno pred dajanjem oceniti razmerje korist/ tveganje.
There is limited experience on the use of the product in sick and debilitated animals, thus the product should only be used based on a risk-benefit assessment for these animals.
Ker so izkušnje pri uporabi zdravila pri bolnih in šibkih živalih omejene, uporabite zdravilo pri teh živalih na osnovi ocene korist/ tveganje.
Care should be taken that the contents of the pipette or the applied dose does not come into contact with the eyes or mouth of the recipient and/ or other animals.
Pazite, da zdravilo ne zaide v oči ali usta zdravljene in/ ali druge živali.
Do not allow recently treated animals to groom each other.
Preprečiti je potrebno, da zdravljena žival ali druge živali z lizanjem mesta nanosa ne zaužijejo zdravila.
Oral uptake by Collies, Old English Sheepdogs and related breeds or crossbreeds should be prevented.
Pazite, da koliji, staroangleški ovčarji, njim sorodne pasme in njihovi mešanci zdravila ne zaužijejo.
It is recommended that cats living in, or travelling to areas endemic for heartworm are treated monthly with the product to protect them from heartworm disease.
Živali, ki živijo ali potujejo na področja, ki so okužena z Dirofilario immitis zdravimo enkrat mesečno.
Whilst the accuracy of diagnosis of feline heartworm infection is limited, it is recommended that attempts be made to check the heartworm status of any cat aged over 6 months, before beginning prophylactic treatment, as use of the product on cats which have adult heartworms may cause serious adverse effects, including death.
Ker pri mačkah dirofilariozo težko diagnosticiramo, priporočamo, da pri mačkah, starejših od 6 mesecev, pred dajanjem zdravila, preverimo, če je inficirana z Dirofilario immitis, kajti dajanje zdravila mačkam, ki so okužene z odraslo obliko Dirofilarie immitis, lahko povzroči hud neželen škodljiv učinek zdravila, tudi smrt.
If adult heartworm infection is diagnosed, the infection should be treated in accordance with current scientific knowledge.
Če ugotovimo, da je žival inficirana z odraslo obliko Dirofilarie immitis, uporabimo običajne postopke zdravljenja.
Do not eat, drink or smoke during application.
Med nanosom ne jejte, pite in kadite.
In very rare cases the product may cause skin sensitisation or transient skin reactions (for example allergy, irritation or tingling).
Osebe z znano preobčutljivostjo za benzilalkohol, imidakloprid ali moksidektin naj se izogibajo stiku z zdravilom. V redkih primerih zdravilo lahko pri občutljivi koži povzroči prehodne kožne reakcije (npr. alergijo, vnetje ali srbenje).
If skin or eye symptoms persist, or the product is accidentally swallowed, seek medical attention and show the package insert to the physician.
Pri zaužitju zdravila ali če vzdraženje kože ali oči traja, poiščite zdravniško pomoč in pokažite navodilo za uporabo.
The solvent in Advocate may stain certain materials including leather, fabrics, plastics and finished surfaces.
Topilo v zdravilu Advocate lahko pusti madeže na usnju, tkaninah, plastiki in lakiranih površinah.
On rare occasions greasy fur, erythema and vomiting can occur.
Pri mačkah se lahko pojavi prehodna srbečica, v redkih primerih mastna dlaka, rdeči kožni madeži in bruhanje.
If the animal licks the application site after treatment, transient neurological signs may be observed infrequently (see section 4.10 –).
Če žival poliže mesto aplikacije, se lahko pojavijo prehodni nevrološki znaki (glej odstavek 4. 10) Ker je zdravilo grenko, se lako živali, ki po nanosu ližejo mesto aplikacije, slinijo.
Salivation may occasionally occur if the animal licks the application site immediately after treatment.
To ni znak zastrupitve, živali se po nekaj minutah nehajo sliniti, ne da bi jih zdravili.
4.7 Use during pregnancy, lactation or lay
3 4. 7 Uporaba v obdobju brejosti, laktacije ali nesnosti
Use only according to the risk-benefit assessment by the responsible veterinarian.
Zdravilo aplicirajte potem, ko odgovorni veterinar oceni prednost in tveganost dajanja.
During treatment with Advocate no other antiparasitic macrocyclic lactone should be administered.
Pri zdravljenju z zdravilom Advocate odsvetujemo sočasno uporabo drugih antiparaziticidov iz skupine makrocikličnih laktonov.
Dosage schedule:
4. 9 Odmerjanje in pot uporabe
The recommended minimum doses are 10 mg/ kg bodyweight imidacloprid and 1.0 mg/ kg bodyweight moxidectin, equivalent to 0.1ml/ kg bodyweight Advocate for cats.
Minimalni odmerek je 10 mg imidakloprida na kg telesne mase ter 1, 0 mg moksidektina na kg telesne mase kar ustreza 0, 1 ml zdravila Advocate za mačke na kg telesne mase.
The treatment schedule should be based on the local epidemiological situation.
Zdravljenje poteka glede na lokalne epidemiološke razmere.
Weight of cat [kg]
Teža mačke v kg
Pipette size to be used
Velikost pipete
Volume Imidacloprid Moxidectin [ml] [mg/ kg bw] [mg/ kg bw]
Imidakloprid (mg/ kg t. m.)
Advocate for small cats
Advocate male mačke
0.4
za 0, 4
minimum of minimum of 10 1
najmanj 10
Advocate for large cats
Advocate velike mačke
0.8
za 0, 8
1-2
1– 2
the appropriate combination of pipettes
ustrezno število pipet
Flea treatment and prevention
Zdravljenje in preprečevaje bolhavosti
Heartworm prevention
Zaščita pred infestacijo z Dirofilario immitis
4 Cats in areas endemic for heartworm, or those which have travelled to endemic areas, may be infected with adult heartworms.
Mačke, ki se nahajajo na področju, kjer se nahajajo prenašalci teh parazitov in mačke, ki na tako področje potujejo, se lahko infestirajo z odraslo obliko Dirofilarie immitis.
Therefore prior to treatment with Advocate, the advice provided in section 4.5. should be considered.
Zato moramo pred dajanjem zdravila Advocate upoštevati navodila iz odstavka 4. 5.
Therefore they can be treated without special precautions.
4 Na področjih, ki niso infestirana z Dirofilario immitis, tudi mačke praviloma niso okužene, zato jih lahko zdravimo, ne da bi upoštevali posebne varnostne ukrepe.
Roundworm and hookworm treatment
Preprečevanje infestacij z različnimi vrstami glist
In areas non-endemic for heartworm, the product can be used as part of a seasonal prevention programme against fleas and gastrointestinal nematodes.
Na področjih, ki so okužena z Dirofilario immitis, mesečno dajanja zdravila preprečuje ponovne infestacije z različnimi vrstami glist Na področjih, ki niso okužena z Dirofilario immitis pa lahko zdravilo uporabljamo za zdravljenje infestacij z želodčno- črevesnimi zajedavci.
Method of administration
Pot uporabe
Reverse the cap and use it to twist and remove the seal from the pipette, as shown.
Vzemite pipeto iz ovojnine, držite jo navpično, zavrtite in snemite pokrov, obrnite ga in prebodite plastično zaporo na pipeti, kot kaže slika.
Place the tip of the pipette on the skin and squeeze the pipette firmly several times to empty its contents directly onto the skin.
Položite konico pipete na kožo in jo nekajkrat močno stisnite, da nanesete vsebino neposredno na kožo.
Application at the base of the skull will minimise the opportunity for the cat to lick the product.
Koža ne sme biti poškodovana.
Apply only to undamaged skin.
Nanos na zatilje preprečuje, da bi mačka zdravilo polizala.
5 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
4. 10 Preveliko odmerjanje (simptomi, nujni ukrepi, protistrupi) (če je potrebno)
After accidental oral ingestion, transient neurological signs such as ataxia, generalised tremors, ocular signs (dilated pupils, little pupillary reflex, nystagmus), abnormal respiration, salivation and vomiting may occur infrequently.
Pri nenamernem zaužitju zdravila se lahko pojavijo prehodni nevrološki znaki (nekontrolirani gibi, drhtenje), očesni znaki (razširjene zenice, slab pupilarni refleks, očesni drget), nenormalno dihanje, slinjenje in bruhanje.
In case of accidental oral uptake, symptomatic treatment should be administered.
Pri nenamernem zaužitju je potrebno simptomatično zdravljenje.
Pharmacotherapeutic group: therapeutic antiparasitic agent; ATC-vet code:
Farmakoterapevtska skupina: ektoparaziticid, oznaka ATCvet:
Imidacloprid, 1-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine is an ectoparasiticide belonging to the chloronicotinyl group of compounds.
Imidakloprid 1 - (6- kloro- 3- piridilmetil) N- nitroimidazolidin- 2- ilideneamin je ektoparaziticid iz skupine kloronikotinilov.
Flea larvae in the pet’ s surroundings are killed after contact with a pet treated with the product.
Ličinke v okolici poginejo, ko pridejo v stik z zdravljeno živaljo.
The ensuing inhibition of cholinergic transmission in insects results in paralysis and death.
Imidakloprid se pri bolhah močno veže na nikotinergične acetilholin receptorje v postsinaptičnem delu njihovega osrednjega živčevja, posledično zavira aktivnost acetilholinesteraze in s tem povzroči ohromitev in pogin zajedavca.
Moxidectin, 23-(O-methyloxime)-F28249 alpha is a second-generation macrocyclic lactone of the milbemycin family.
Moksidektin 23 - (0- methyloxime) - F28249 alfa je makrociklični lakton druge generacije in spada v skupino milbemicinov.
Moxidectin is active against larval stages (L3, L4) of Dirofilaria immitis.
Moksidektin deluje na ličinke Dirofilarie immitis (oblike L3, L4) kakor tudi na želodčno- črevesne nematode.
The result is flaccid paralysis of affected parasites, followed by their death and/ or expulsion.
Povečana prepustnost celične membrane za ione klora privede do hiperpolarizacije v živčnih in mišičnih celicah nematoda, kar povzroči paralizo in pogin zajedavca.
After topical administration of the product, imidacloprid is rapidly distributed over the animal’ s skin within one day of application.
Na površini kože se nahaja do naslednjega nanosa.
It can be found on the body surface throughout the treatment interval.
Moksidektin se resorbira skozi kožo.
Moxidectin is absorbed through the skin, reaching maximum plasma concentrations approximately 1 to 2 days after treatment in cats.
Najvišjo plazemsko koncentracijo dosežemo 1 do 2 dni po nanosu.
See section 6.6.
Glej odstavek 6. 6.
6.5 Nature and composition of immediate packaging
Ne shranjujte pri temperaturi nad 30 °C.
0.4 ml and 0.8 ml per pipette
6 6. 5 Vrsta ovojnine in vsebina
Blister pack containing 3, 4, 6, 21 or 42 unit dose pipettes
Primarna ovojnina: pipeta s 0, 4 ml in 0, 8 ml Oprema: pretisni omot s 3, 4, 6, 21 ali 42 pipetami za enkratno dajanje Material primarne ovojnine: bela polipropilenska pipeta za enkratno dajanje s pokrovom z navojem.
Advocate should not be allowed to enter surface waters as it has harmful effects on aquatic organisms.
Advocate ne sme priti v vodotoke, ker je lahko nevaren za ribe in druge vodne organizme.
Bayer Animal Health GmbH D-51368 Leverkusen Germany
Bayer Animal Health GmbH D- 51368 Leverkusen Nemčija
Advocate spot-on solution for small dogs Advocate spot-on solution for medium dogs Advocate spot-on solution for large dogs Advocate spot-on solution for extra-large dogs
Advocate, raztopina za kožni nanos za male pse Advocate, raztopina za kožni nanos za srednje velike pse Advocate, raztopina za kožni nanos za velike pse Advocate, raztopina za kožni nanos za zelo velike pse
Advocate for dogs contains 100 mg/ ml imidacloprid and 25 mg/ ml moxidectin.
100 mg/ ml imidakloprida in 25 mg/ ml moksidektina
Each unit dose (pipette) delivers:
Enota odmerka (pipeta) za pse vsebuje:
Imidacloprid
Imidakloprid Moksidectin
Moxidectin
Advocate za male pse (≤ 4 kg)
10 mg
40 mg 10 mg
Advocate for large dogs (> 10-25 kg) Advocate for extra-large dogs (> 25-40 kg)
Advocate za srednje velike pse (> 4- 10 kg) Advocate za velike pse (> 10- 25 kg) Advocate za zelo velike pse (> 25- 40 kg)
250 mg 400 mg
100 mg 25 mg 250 mg 62, 5 mg 400 mg 100 mg
Excipients:
Pomožne snovi: benzilalkohol
Benzyl alcohol Butylhydroxytoluene 1 mg/ ml (E 321; as antioxidant)
1 mg/ ml butilhidroksitoluena (E321 kot antioksidant)
For dogs suffering from, or at risk from, mixed parasitic infections:
Za pse, ki imajo ali so izpostavljene mešanim parazitarnim infestacijam.
For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of biting lice (Trichodectes canis), treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis), prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis), treatment of Angiostrongylus vasorum and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis).
Za uničevanje in zatiranje bolh (Ctenocephalides felis), uši (Trichodectes canis), za zdravljenje ušesnih garij (Otodectes cynotis), garij vrste Sarcoptes (Sarcoptes scabiei var. canis), demodikoze, ki jo povzroča Demodex canis, za zaščito pred ličinkami Dirofilarie immitis (oblika L3, L4) za zaščito pred zajedavcem Angiostrongylus vasorum ter za zdravljenje okužb z želodčno- črevesnimi nematodi (oblika L4, nezrele odrasle in odrasle oblike Toxocara canis, Ancylostma caninum in Uncinaria stenocephala, odrasle oblike Toxascaris leonina in Trichuris vulpis).
For cats, the corresponding “ Advocate for cat ” product, which contains 100 mg/ ml imidacloprid and 10 mg/ ml moxidectin, must be used.
Pri mačkah uporabljamo ustrezno obliko zdravila Advocate za mačke, ki vsebuje 100 mg/ ml imidakloprida in 10 mg/ ml moksidektina.
Do not allow recently treated animals to groom each other.
Preprečiti je potrebno, da zdravljena žival ali druge živali z lizanjem mesta nanosa zdravila ne zaužijejo.
When the product is applied in 3 to 4 separate spots (see section 4.9), specific care should be taken to prevent the animal licking the application sites.
Če zdravilo nanesemo na 3 do 4 različna mesta (glej odstavek 4. 9) pazimo, da žival ne liže mesto nanosa.
This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under section 4.9; in particular, oral uptake by the recipient and/ or other animals in close contact should be prevented.
Še posebno moramo paziti, da tretirana žival in/ ali druge živali, ki so z njo v tesnem stiku, zdravila ne zaužijejo.
Advocate should not be allowed to enter surface waters as it has harmful effects on aquatic organisms: moxidectin is highly toxic to aquatic organisms.
Moksidektin je zelo toksičen za vodne organizme.