natgillin/translations-raw huggingface dataset:
In repeated dose toxicity studies, the administration of losartan induced a decrease in the red blood cell parameters (erythrocytes, haemoglobin, haematocrit), a rise in urea-N in the serum and occasional rises in serum creatinine, a decrease in heart weight (without a histological correlate) and gastrointestinal changes (mucous membrane lesions, ulcers, erosions, haemorrhages).
V študijah toksičnosti pri ponavljajočih se odmerkih je uporaba losartana povzročila zmanjšanje števila eritrocitov, hemoglobina, hematokrita, povečanje količine N- sečnine v serumu in občasno zvišanje kreatinina v serumu, zmanjšanje mase srca (brez histološke povezave) in spremembe v prebavilih (poškodbe, razjede, erozije in krvavitve mukozne membrane).
Like other substances that directly affect the renin-angiotensin system, losartan has been shown to induce adverse effects on the late foetal development, resulting in foetal death and malformations.
Tako kot druge snovi, ki neposredno vplivajo na sistem renin- angiotenzin, ima tudi losartan neželene učinke na pozni razvoj ploda, kar povzroči smrt ploda in malformacije.
37 6.1 List of excipients
6. 1 Seznam pomožnih snovi
Each tablet contains the following inactive ingredients: microcrystalline cellulose (E460) lactose monohydrate pregelatinized maize starch magnesium stearate (E572) hydroxypropyl cellulose (E463) hypromellose (E464)
33 predgelirani koruzni škrob magnezijev stearat (E572) hidroksipropilceluloza (E463) hipromeloza (E464)
Cozaar 12.5 mg, 25 mg, 50 mg and 100 mg contain potassium in the following amounts:
100 mg tablete vsebujejo kalij v naslednjih količinah:
Cozaar 12.5 mg tablets also may contain carnauba wax E 903, titanium dioxideE171, indigo carmine E132 aluminum lake.
Cozaar 12, 5 mg tablete lahko vsebujejo še karnauba vosek (E903), titanov dioksid (E171), indigo karmin (E132).
Cozaar 25 mg tablets also may contain Carnauba wax (E903), Titanium dioxide (E171).
Cozaar 25 mg tablete lahko vsebujejo še karnauba vosek (E903), titanov dioksid (E171).
Cozaar 50 mg tablets also may contain Carnauba wax (E903), Titanium dioxide (E171).
Cozaar 50 mg tablete lahko vsebujejo še karnauba vosek (E903), titanov dioksid (E171).
Cozaar 100 mg tablets also may contain Carnauba wax (E903), Titanium dioxide (E171).
Cozaar 100 mg tablete lahko vsebujejo še karnauba vosek (E903), titanov dioksid (E171).
Cozaar 12.5 mg - PVC/ PE/ PVDC blister packages with aluminum foil lidding in packs of 7, 14, 21, 28, 50, 98, 210 or 500 tablets.
Cozaar 12, 5 mg - PVC/ PE/ PVDC pretisni omoti s prevleko iz aluminijaste folije v pakiranjih po 7, 14, 21, 28, 50, 98, 210 ali 500 tablet.
A package containing 35 tablets (21 pcs of 12.5 mg tablet and 14 pcs of the 50 mg tablet) or 28 tablets (21 pcs of 12.5 mg tablet and 7 pcs of the 50 mg tablet) is available in a PVC/ PE/ PVDC titration blister package.
Pakiranje po 35 tablet (enaindvajset 12, 5 mg tablet in štirinajst 50 mg tablet) ali 28 tablet (enaindvajset 12, 5 mg tablet in sedem 50 mg tablet) je na voljo kot titracijsko pakiranje s PVC/ PE/ PVDC pretisnim omotom.
Cozaar 25 mg - PVC/ PE/ PVDC blister packages with aluminum foil lidding in packs of 7 or 28 tablets.
Cozaar 25 mg - PVC/ PE/ PVDC pretisni omoti s prevleko iz aluminijaste folije v pakiranjih po 7 ali 28 tablet.
Cozaar 50 mg - PVC/ PE/ PVDC blister packages with aluminum foil lidding in packs of 7, 10, 14, 20, 28, 30, 50, 56, 84, 90, 98, 280 or 500 tablets.
Cozaar 50 mg - PVC/ PE/ PVDC pretisni omoti s prevleko iz aluminijaste folije v pakiranjih po 7, 10, 14, 20, 28, 30, 50, 56, 84, 90, 98, 280 ali 500 tablet.
PVC/ aluminum foil/ nylon blisters with aluminum foil lidding in packs of 10, 14 and 28.
PVC/ aluminijasta folija/ najlon pretisni omoti s prevleko iz aluminijaste folije v pakiranjih po 10, 14 in 28 tablet.
Cozaar 100 mg - PVC/ PE/ PVDC blister packages with aluminum foil lidding in packs of 7, 10, 14, 15, 20, 28, 30, 50, 56, 84, 90, 98 or 280 tablets.
Cozaar 100 mg - PVC/ PE/ PVDC pretisni omoti s prevleko iz aluminijaste folije v pakiranjih po 7, 10, 14, 15, 20, 28, 30, 50, 56, 84, 90, 98 ali 280 tablet.
38 6.6 Special precautions for disposal
6. 6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom
39 LABELLING
35 OZNAČEVANJE
40 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
36 PODATKI NA ZUNANJI OVOJNINI
Outer carton for Cozaar 12.5 mg blister
Škatla s pretisnimi omoti za Cozaar 12, 5 mg
Cozaar 12.5 mg film-coated tablets
Cozaar 12, 5 mg filmsko obložene tablete
Each tablet contains 12.5 mg losartan potassium.
Vsaka tableta vsebuje 12, 5 mg kalijevega losartanata.
7, 14, 21, 28, 50, 98, 210 or 500 film-coated tablets.
7, 14, 21, 28, 50, 98, 210 ali 500 filmsko obloženih tablet.
42 MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS
38 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
Blister for Cozaar 12.5 mg film-coated tablets
Pretisni omot za Cozaar 12, 5 mg filmsko obložene tablete
[See Annex I - To be completed nationally] [For referral procedures]
[Glejte Dodatek I – Izpolni država članica]
43 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
39 PODATKI NA ZUNANJI OVOJNINI
Outer carton for Cozaar 12.5 mg HDPE bottle
Škatla s HDPE plastenko za Cozaar 12, 5 mg
See leaflet for further information.
100 filmsko obloženih tablet.
45 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
41 PODATKI NA PRIMARNI OVOJNINI
Bottle label for Cozaar 12.5 mg HDPE bottle
Nalepka za HDPE plastenko za Cozaar 12, 5 mg
N/ A
[Izpolni država članica]
47 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
43 PODATKI NA ZUNANJI OVOJNINI
Outer carton for Cozaar 25 mg
Škatla za Cozaar 25 mg
Cozaar 25 mg film-coated tablets
Cozaar 25 mg filmsko obložene tablete
Each tablet contains 25 mg losartan potassium.
Vsaka tableta vsebuje 25 mg kalijevega losartanata.
7 film-coated tablets 28 film-coated tablets
7 filmsko obloženih tablet 28 filmsko obloženih tablet
49 MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS
45 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
Blister for Cozaar 25 mg film-coated tablets
Pretisni omot za Cozaar 25 mg filmsko obložene tablete
50 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
46 PODATKI NA ZUNANJI OVOJNINI
Outer carton for Cozaar 50 mg blister
Škatla s pretisnimi omoti za Cozaar 50 mg
Cozaar 50 mg film-coated tablets
Cozaar 50 mg filmsko obložene tablete
Each tablet contains 50 mg losartan potassium.
Vsaka tableta vsebuje 50 mg kalijevega losartanata.
7, 10, 14, 20, 28, 30, 50, 56, 84, 90, 98, 280 or 500 tablets.
7, 10, 14, 20, 28, 30, 50, 56, 84, 90, 98, 280 in 500 tablet.
52 MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS
48 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
Blister for Cozaar 50 mg film-coated tablets
Pretisni omot za Cozaar 50 mg filmsko obložene tablete
[See Annex I - To be completed nationally] [For referral procedures]
[Glejte Dodatek 1 – Izpolni država članica]
53 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
49 PODATKI NA ZUNANJI OVOJNINI
Outer carton for Cozaar 50 mg HDPE bottle
Škatla s HDPE plastenko za Cozaar 50 mg
100 or 300 tablets.
100 ali 300 tablet.
55 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
51 PODATKI NA PRIMARNI OVOJNINI
Bottle label for Cozaar 50 mg HDPE bottle
Nalepka za HDPE plastenko za Cozaar 50 mg
57 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
53 PODATKI NA ZUNANJI OVOJNINI
Outer carton for Cozaar 100 mg blister
Škatla s pretisnimi omoti za Cozaar 100 mg
Cozaar 100 mg film-coated tablets
Cozaar 100 mg filmsko obložene tablete
Each tablet contains 100 mg losartan potassium.
Vsaka tableta vsebuje 100 mg kalijevega losartanata.
7, 10, 14, 15, 20, 28, 30, 50, 56, 84, 90, 98, or 280 tablets.
7, 10, 14, 15, 20, 28, 30, 50, 56, 84, 90, 98 ali 280 tablet.
59 MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS
55 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
Blister for Cozaar 100 mg film-coated tablets
Pretisni omot za Cozaar 100 mg filmsko obložene tablete
60 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
56 PODATKI NA ZUNANJI OVOJNINI
Outer carton for Cozaar 100 mg HDPE Bottle
Škatla s HDPE plastenko za Cozaar 100 mg
100 tablets.
100 tablet.
62 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
58 PODATKI NA PRIMARNI OVOJNINI
Bottle label for Cozaar 100 mg HDPE Bottle
Nalepka za HDPE plastenko za Cozaar 100 mg
Keep the blister in the outer carton.
Shranjujte v originalni plastenki.
Outer carton for Cozaar 12.5 mg and 50 mg (titration package blister)
Zgibanka za Cozaar 12, 5 mg in 50 mg (pretisni omoti za titracijsko odmerjanje)
Cozaar 12.5 mg film-coated tablets Cozaar 50 mg film-coated tablets
Cozaar 12, 5 mg filmsko obložene tablete Cozaar 50 mg filmsko obložene tablete
Each Cozaar 12.5 mg film-coated mg tablet contains 12.5 mg losartan potassium.
Vsaka COZAAR 12, 5 mg filmsko obložena tableta vsebuje 12, 5 mg kalijevega losartanata.
28 day initiation pack Each pack contains a total of 35 tablets:
28- dnevno začetno pakiranje Vsako pakiranje vsebuje 35 tablet:
21 film-coated tablets of 12.5 mg and 14 film-coated tablets of 50 mg losartan potassium.
21 filmsko obloženih tablet z 12, 5 mg in 14 filmsko obloženih tablet s 50 mg kalijevega losartanata.
21 film-coated tablets of 12.5 mg and 7 film-coated tablets of 50 mg losartan potassium.
21 filmsko obloženih tablet z 12, 5 mg in 7 filmsko obloženih tablet s 50 mg kalijevega losartanata.
65 Keep the blister in the outer carton.
Pretisni omot shranjujte v škatli.
66 PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING Trifold Blister for Cozaar 12.5 mg film-coated tablets Blister for Cozaar 50 mg film-coated tablets
62 PODATKI NA PRIMARNI OVOJNINI Zgibanka Pretisni omot za Cozaar 12, 5 mg filmsko obložene tablete Pretisni omot za Cozaar 50 mg filmsko obložene tablete
[See Annex I - To be completed nationally]
[Glejte Dodatek 1 – Izpolni država članica]
WEEK 1 (day 1-7) 1 tablet = 12,5 mg daily Use this card first
TEDEN (1. - 7. dan) 1 tableta = 12, 5 mg dnevno Najprej porabite tablete s te ploščice.
WEEK 2 (Day 8-14) 2 tablets = 25 mg once daily
TEDEN (8. - 14. dan) 2 tableti = 25 mg enkrat dnevno
WEEK 3 (day 15-21) 1 tablet = 50 mg daily
TEDEN (15. - 21. dan) 1 tableta = 50 mg dnevno
WEEK 4 (day 22-28) 1 tablet = 50 mg daily
TEDEN (22. - 28. dan) 1 tableta = 50 mg dnevno
Cozaar film-coated tablets losartan potassium
64 NAVODILO ZA UPORABO
Read all of this leaflet carefully before taking this medicine.
Cozaar filmsko obložene tablete kalijev losartanat
• Keep this leaflet.
Pred uporabo natančno preberite navodilo! • Navodilo shranite.
What Cozaar is and what it is used for 2.
Kaj je zdravilo Cozaar in za kaj ga uporabljamo 2.
Before you take Cozaar 3.
Kaj morate vedeti, preden boste vzeli zdravilo Cozaar 3.
How to take Cozaar 4.
Kako jemati zdravilo Cozaar 4.
How to store Cozaar 6.
Shranjevanje zdravila Cozaar 6.
Cozaar is used • to treat patients with high blood pressure (hypertension) • to protect the kidney in hypertensive type 2 diabetic patients with laboratory evidence of impaired renal function and proteinuria ≥ 0.5 g per day (a condition in which urine contains an abnormal amount of protein). • to treat patients with chronic heart failure when therapy with specific medicines called angiotensin-converting-enzyme inhibitors (ACE inhibitors, medicine used to lower high blood pressure) is not considered suitable by your doctor.
Zdravilo Cozaar se uporablja: • za zdravljenje bolnikov z visokim krvnim tlakom (hipertenzijo). • za zaščito ledvic pri bolnikih s hipertenzijo in sladkorno boleznijo tipa 2, pri katerih so laboratorijski izvidi pokazali okvaro ledvic in proteinurijo ≥ 0, 5 g na dan (stanje s preveliko količino beljakovin v urinu). • za zdravljenje bolnikov s kroničnim srčnim popuščanjem, če zdravnik meni, da zdravljenje z zaviralci angiotenzinske konvertaze (zaviralci ACE, zdravila za zniževanje krvnega tlaka) ni primerno. • Pri bolnikih z visokim krvnim tlakom in zadebeljenim levim prekatom zdravilo Cozaar zmanjša tveganje za možgansko kap.
If your heart failure has been stabilised with an ACE inhibitor you should not be switched to losartan. • in patients with high blood pressure and a thickening of the left ventricle, COZAAR has been shown to decrease the risk of stroke (“ LIFE indication”).
Če je srčno popuščanje stabilno ob zdravljenju z zaviralcem ACE, vam zdravnik zdravila ne sme zamenjati za losartan.
BEFORE YOU TAKE Cozaar
KAJ MORATE VEDETI, PREDEN BOSTE VZELI ZDRAVILO COZAAR
• if you are allergic (hypersensitive) to losartan or to any of its other ingredients, • if your liver function is severely impaired, • if you are, think you may be or are planning to become pregnant (see also “ Pregnancy and breast-feeding”), 68 • if you are breast-feeding.
• če ste alergični na (preobčutljivi za) losartan ali katerokoli sestavino zdravila. • če imate hudo okvaro jeter. • če ste noseči, mislite, da ste noseči ali če nameravate zanositi (glejte tudi poglavje "Nosečnost in dojenje") • če dojite.
Take special care with Cozaar
65 Bodite posebno pozorni pri jemanju zdravila Cozaar
It is important to tell your doctor before taking Cozaar:
Preden vzamete zdravilo Cozaar, se posvetujte z zdravnikom ali s farmacevtom:
• if you have had a history of angiooedema (swelling of the face, lips, throat, and/ or tongue) (see also section 4 ‘ Possible side effects’), • if you suffer from excessive vomiting or diarrhoea leading to an extreme loss of fluid and/ or salt in your body, • if you receive diuretics (medicines that increase the amount of water that you pass out through your kidneys) or are under dietary salt restriction leading to an extreme loss of fluid and salt in your body (see section 3 ‘ Dosage in special patient groups’), • if you are known to have narrowing or blockage of the blood vessels leading to your kidneys or if you have received a kidney transplant recently, • if your liver function is impaired (see sections 2 "Do not take Losartan" and 3 ‘ Dosage in special patient groups’), • if you suffer from heart failure with or without renal impairment or concomitant severe life threatening cardiac arrhythmias.
• če ste kdaj imeli angioedem (otekanje obraza, ustnic, grla in/ ali jezika) (glejte tudi poglavje 4 "Možni neželeni učinki"). • če močno bruhate ali imate hudo drisko in zato izgubljate veliko tekočine in/ ali soli. • če jemljete diuretike (zdravila, ki povečajo izločanje vode skozi ledvice) ali ste na dieti s hrano z zmanjšano količino soli, zaradi česar iz telesa izgubljate večje količine tekočine in soli (glejte poglavje 3 "Odmerjanje pri posebnih skupinah bolnikov"). • če veste, da imate zožanje ali zaprtje krvnih žil, ki vodijo do ledvic, ali če so vam pred kratkim presadili ledvico, • če imate okvaro jeter (glejte poglavje 2 "Ne jemljite zdravila Cozaar" in poglavje 3 "Odmerjanje pri posebnih skupinah bolnikov"). • če imate srčno popuščanje z okvaro ledvic ali brez ali sočasne hude življensko nevarne srčne aritmije.
Special caution is necessary when you are treated with a ß-blocker concomitantly, • if you have problems with your heart valves or heart muscle, • if you suffer from coronary heart disease (caused by a reduced blood flow in the blood vessels of the heart) or from cerebrovascular disease (caused by a reduced blood circulation in the brain), • if you suffer from primary hyperaldosteronism (a syndrome associated with increased secretion of the hormone aldosterone by the adrenal gland, caused by an abnormality within the gland).
Posebna previdnost je potrebna, če sočasno jemljete beta zaviralec. • če imate težave s srčnimi zaklopkami ali srčno mišico. • če imate koronarno srčno bolezen (zaradi zmanjšanega krvnega obtoka v srčnih žilah) ali možganskožilno bolezen (zaradi zmanjšanega krvnega obtoka v možganih). • če imate primarni hiperaldosteronizem (sindrom povezan s povečanim izločanjem hormona aldosterona iz nadledvične žleze zaradi okvare znotraj železe).
Take particular care if you are taking the following medicines while under treatment with Cozaar: • other blood pressure lowering medicines as they may additionally reduce your blood pressure.
Še posebej pozorni bodite, če med zdravljenjem z zdravilom Cozaar jemljete katero od naslednjih zdravil: • druga zdravila za zniževanje krvnega tlaka, ker lahko še dodatno znižajo vaš krvni tlak.
Blood pressure may also be lowered by one of the following drugs/ class of drugs: tricyclic antidepressants, antipsychotics, baclofene, amifostine, • medicines which retain potassium or may increase potassium levels (e. g. potassium supplements, potassium-containing salt substitutes or potassium-sparing medicines such as certain diuretics [amiloride, triamteren, spironolactone] or heparine), • non-steroidal anti-inflammatory drugs such as indomethacin, including cox-2-inhibitors (medicines that reduce inflammation, and can be used to help relieve pain) as they may reduce the blood lowering effect of losartan.
Krvni tlak vam lahko zniža tudi katero od naslednjih zdravil/ skupin zdravil: triciklični antidepresivi, antipsihotiki, baklofen, amifostin. • zdravila, ki zadržujejo kalij ali lahko povečajo količino kalija (npr. dodatki kalija, nadomestki soli, ki vsebujejo kalij, zdravila, ki varčujejo kalij, kot so določeni diuretiki [amilorid, trimateren, spironolakton], ali heparin). • nesteroidne antirevmatike, kot je indometacin, vključno z zaviralci COX- 2 (zdravila, ki zdravijo vnetje in se lahko uporabljajo za odpravljanje bolečine), ker lahko zmanjšajo losartanov učinek znižanja krvnega tlaka.
Lithium containing medicines should not be taken in combination with losartan without close supervision by your doctor.
Če imate ledvično okvaro, lahko sočasna uporaba teh zdravil vodi do dodatnega poslabšanja ledvične funkcije. • Zdravila, ki vsebujejo litij, se v kombinaciji z losartanom brez natančnega nadzora zdravnika ne smejo uporabljati.
Pregnancy and breast-feeding 69 You should not take losartan in the first 12 weeks of pregnancy, and you must not take them at all after the 13th week as their use during pregnancy may possibly be harmful to the baby.
Losartana naj se v prvih 12 tednih nosečnosti ne bi jemalo, od 13. tedna dalje pa je njegova uporaba celo prepovedana, ker lahko škoduje otroku.
A switch to a suitable alternative treatment should be carried out in advance of a planned pregnancy.
Zdravnik naj bi vam predpisal drugo zdravilo, še preden nameravte zanositi.
Use in children and adolescents
66 Uporaba pri otrocih in mladostnikih
Important information about some of the ingredients of Cozaar
Pomembne informacije o nekaterih sestavinah zdravila Cozaar
Cozaar contains lactose monohydrate.
Zdravilo Cozaar vsebuje laktozo monohidrat.
Always take Cozaar exactly as your doctor has instructed you.
Pri jemanju zdravila Cozaar natančno upoštevajte zdravnikova navodila.
It is important to continue taking Cozaar for as long as your doctor prescribes it in order to maintain smooth control of your blood pressure.
Tako vzdržujete enakomeren nadzor krvnega tlaka.
Patients with High Blood Pressure Treatment usually starts with 50 mg losartan (one tablet Cozaar 50 mg) once a day.
Bolniki z visokim krvnim tlakom Zdravljenje se običajno začne s 50 mg losartana (ena tableta Cozaar 50 mg) enkrat na dan.
The maximal blood pressure lowering effect should be reached 3-6 weeks after beginning treatment.
Največji učinek zmanjšanja krvnega tlaka naj bi bil dosežen 3- 6 tednov po začetku zdravljenja.
In some patients the dose may later be increased to 100 mg losartan (two tablets Cozaar 50 mg) once daily If you have the impression that the effect of losartan is too strong or too weak, please talk to your doctor or pharmacist.
Če imate občutek, da je učinek losartana premočan ali prešibek, se posvetujte z zdravnikom ali s farmacevtom.
Patients with high blood pressure and type 2 diabetes Treatment usually starts with 50 mg losartan (one tablet Cozaar 50 mg) once a day.
Bolniki z visokim krvnim tlakom in s sladkorno boleznijo tipa 2 Zdravljenje se običajno začne s 50 mg losartana (ena tableta Cozaar 50 mg) enkrat na dan.
The dose may later be increased to 100 mg losartan (two tablets Cozaar 50 mg) once daily depending on your blood pressure response.
Odmerek se kasneje lahko poveča na 100 mg losartana (dve tableti Cozaar 50 mg) enkrat na dan, glede na odziv krvnega tlaka.
Losartan tablets may be administered with other blood pressure lowering medicines (e. g. diuretics, calcium channel blockers, alpha- or beta-blockers, and centrally acting agents) as well as with insulin and other commonly used medicines that decrease the level of glucose in the blood (e. g. sulfonylureas, glitazones and glucosidase inhibitors).
Tablete z losartanom se lahko jemljejo skupaj z drugimi zdravili za zniževanje krvnega tlaka (npr. diuretiki, zaviralci kalcijevih kanalčkov, alfa ali beta zaviralci in zdravili, ki delujejo na centralno živčevje), kot tudi z insulinom in drugimi običajno uprabljenimi zdravili za zmanjševanje količine glukoze v krvi (npr. sulfonilsečnino, glitazoni, zaviralci glukozidaze).
Patients with Heart Failure Treatment usually starts with 12.5 mg losartan (one tablet Cozaar 12.5 mg) once a day.
Bolniki s srčnim popuščanjem Zdravljenje se običajno začne z 12, 5 mg losartana (ena tableta Cozaar 12, 5 mg) enkrat na dan.
70 Generally, the dose should be increased weekly step-by-step (i. e., 12.5 mg daily during the first week, 25 mg daily during the second week, 50 mg daily during the third week) up to the usual maintenance dose of 50 mg losartan (one tablet Cozaar 50 mg) once daily, according to your condition.
12, 5 mg dnevno prvi teden, 25 mg dnevno drugi teden, 50 mg dnevno tretji teden) do običajnega vzdrževalnega odmerka 50 mg losartana (ena tableta Cozaar 50 mg) enkrat na dan.
In the treatment of heart failure, losartan is usually combined with a diuretic (medicine that increases the amount of water that you pass out through your kidneys) and/ or digitalis (medicine that helps to make the heart stronger and more efficient) and/ or a beta-blocker.
Pri zdravljenju srčnega popuščanje se losartan običajno kombinira z diuretikom (zdravilo, ki poveča količino vode, ki se izloči skozi ledvice) in/ ali digitalisom (zdravilo, ki pripomore, da je srce močnejše in učinkovitejše) in/ ali beta zaviralcem.
The use of losartan is not recommended in patients with severe hepatic impairment (see section "Do not take losartan").
67 Uporabe losartana ne priporočamo za bolnike s hudo okvaro jeter (glejte poglavje "Ne jemljite zdravila Cozaar").
Administration
Jemanje zdravila
This is a serious but rare side effect, which affects more than 1 out of 10,000 patients but fewer than 1 out of 1,000 patients.
To je resen vendar redek neželeni učinek, ki prizadane več kot 1 od 10. 000 bolnikov vendar manj kot 1 od 1. 000 bolnikov.
The side effects of medicines are classified as follows: very common: happening in more than 1 in 10 patients common: uncommon rare: very rare: not known
Neželeni učinki so razvrščeni takole: zelo pogosti: pogosti: občasni: redki: zelo redki: neznana pogostnost:
happening in 1 in 100 to 1 in 10 patients happening in 1 in 1,000 to 1 in 100 patients happening in 1 in 10,000 to 1 in 1,000 patients happening in less than 1 in 10,000 patients (cannot be estimated from the available data)
pojavijo se pri več kot 1 od 10 bolnikov pojavijo se pri 1 ali več od 100 ter pri manj kot 1 od 10 bolnikov pojavijo se pri 1 ali več od 1. 000 ter manj kot 1 od 100 bolnikov pojavijo se pri 1 ali več od 10. 000 ter manj kot 1 od 1. 000 bolnikov pojavijo se pri manj kot 1 od 10. 000 bolnikov (iz razpoložljivih podatkov se ne da oceniti)
71 The following side effects have been reported with Cozaar:
Poročali so o naslednjih
Common: • dizziness, • low blood pressure, • debility, • fatigue, • too less sugar in the blood (hypoglycaemia), • too much potassium in the blood (hyperkalaemia).
Pogosti: • omotica • nizek krvni tlak • slabotnost • utrujenost • premalo sladkorja v krvi (hipoglikemija) • preveč kalija v krvi (hiperkaliemija)