natgillin/translations-raw huggingface dataset:
However, anti-HBs antibody concentrations decreased as age and body mass index increased; they were also lower in male than in female subjects.
Koncentracije protiteles anti- HB so bile sicer manjše tudi zaradi višje starosti in indeksa telesne mase, bile pa so sicer nižje pri moških kot pri ženskah.
The seropositivity rate for anti-HAV antibodies after Twinrix Adult was 97% and 96% at 7 and 12 months respectively versus 99% and 98% after the GlaxoSmithKline Biologicals monovalent hepatitis A vaccine and 99% at both 7 and 12 months after another licensed monovalent hepatitis A vaccine.
Stopnja seropozitivnosti za protitelesa anti- HAV po dajanju cepiva Twinrix za odrasle je bila 97% po 7 mesecih in 96% po 12 mesecih, po dajanju monovalentnega cepiva proti hepatitisu A izdelovalca GlaxoSmithKline Biologicals pa 99 in 98% (po 7 in po 12 mesecih) in 99% po 7 in 12 mesecih nekega drugega registriranega monovalentnega cepiva proti hepitatisu A.
7 In two long term clinical studies conducted in adults, persistence of anti-HAV and anti-HBs antibodies has been proven up to 60 months following the initiation of a primary vaccination course of Twinrix Adult in the majority of vaccinees.
7 V dveh dolgotrajnih kliničnih raziskavah so pri večini cepljenih odraslih oseb dokazali prisotnost anti - HAV in anti- HBs protiteles še do 60 mesecev po začetku osnovnega cepljenja s cepivom Twinrix za odrasle.
The kinetics of decline of anti-HAV and anti-HBs antibodies were shown to be similar to those of the monovalent vaccines.
Kinetika upadanja nivoja anti- HAV in anti- HBs protiteles je bila podobna kot pri monovalentnih cepivih.
These data were generated with the former Twinrix formulation containing thiomersal and a preservative.
Ti podatki so bili pridobljeni pri uporabi prejšnje formulacije cepiva Twinrix, ki je vsebovala tiomersal in konzervans.
A clinical study conducted with the current formulation of Twinrix in adults showed that the current formulation elicited similar seroprotection and seroconversion rates as compared to the former formulation.
Pri klinični študiji, izvedeni s sedanjo obliko cepiva Twinrix, se je izkazalo, da sedanja formulacija pri odraslih izzove podobno serozaščito in odstotek serokonverzije kot prejšnja formulacija.
Non-clinical data reveal no special hazard for humans based on general safety studies (see section 4.6).
Predklinični podatki na osnovi običajnih študij varnosti ne kažejo posebnega tveganja za človeka (glejte poglavje 4. 6).
1 ml of suspension in a vial (type I glass) with a plunger stopper (rubber butyl).
1 ml suspenzije v viali (steklo tipa I) z zamaškom (butilna guma).
Pack sizes of 1, 10 and 25.
1, 10 in 25.
8 The vaccine should be well shaken to obtain a slightly opaque, white suspension and visually inspected for any foreign particulate matter and/ or variation of physical aspect prior to administration.
8 Pred uporabo morate cepivo dobro pretresti, da nastane rahlo motna bela suspenzija in ga vizualno pregledati glede morebitnih tujih delcev in/ ali odstopanja od fizikalnega videza.
20 September 1996 Date of latest renewal:
20. september 1996 Datum zadnjega podaljšanja dovoljenja za promet:
Twinrix Adult, suspension for injection in prefilled syringe Hepatitis A (inactivated) and hepatitis B(rDNA) (HAB) vaccine (adsorbed).
Twinrix za odrasle, suspenzija za injiciranje v napolnjeni injekcijski brizgi Cepivo proti hepatitisu A, inaktivirano, in hepatitisu B, rekombinantno (HAB), adsorbirano
Suspension for injection in prefilled syringe Turbid white suspension
Suspenzija za injiciranje v napolnjeni injekcijski brizgi Motna bela suspenzija
11 Twinrix Adult is not recommended for postexposure prophylaxis (e. g. needle stick injury).
11 Cepivo ni bilo preizkušeno pri bolnikih z oslabljeno imunostjo.
12 Data on outcomes of a limited number of pregnancies in vaccinated women do not indicate any adverse effects of Twinrix Adult on pregnancy or on the health of the fetus/ newborn child.
12 Dojenje
13 Common: gastrointestinal symptoms, diarrhoea, nausea Uncommon: vomiting, abdominal pain*
13 Bolezni kože in podkožja Redki: izpuščaj, srbenje Zelo redki: koprivnica
Following widespread use of the monovalent hepatitis A and/ or hepatitis B vaccines, the following undesirable events have additionally been reported in temporal association with vaccination.
Pri spremljanju množične uporabe monovalentnih cepiv proti hepatitisu A in/ ali hepatitisu B so dodatno poročali o naslednjih neželenih učinkih, ki o bili časovno povezani s cepljenjem.
14 Abnormal liver function tests
14 Bolezni živčevja Multipla skleroza, mielitis, ohromelost obraza, polinevritis, kot je Guillain- Barréjev sindrom (z ascendentno paralizo), optični nevritis
15 In two long term clinical studies conducted in adults, persistence of anti-HAV and anti-HBs antibodies has been proven up to 60 months following the initiation of a primary vaccination course of Twinrix Adult in the majority of vaccinees.
15 V dveh dolgotrajnih kliničnih raziskavah so pri večini cepljenih odraslih oseb dokazali prisotnost anti - HAV in anti- HBs protiteles še do 60 mesecev po začetku osnovnega cepljenja s cepivom Twinrix za odrasle.
Pack sizes of 1, 10 and 25 with or without needles.
1, 10 ali 25 z iglami ali brez njih.
16 The vaccine should be well shaken to obtain a slightly opaque, white suspension and visually inspected for any foreign particulate matter and/ or variation of physical aspect prior to administration.
16 Pred uporabo morate cepivo dobro pretresti, da nastane rahlo motna bela suspenzija in ga vizualno pregledati glede morebitnih tujih delcev in/ ali odstopanja od fizikalnega videza.
The Marketing Authorisation Holder will continue to submit annual PSURs.
Imetnik dovoljenja za promet z zdravilom bo periodično poročilo o varnosti zdravila še naprej predajal letno.
Twinrix Adult – Suspension for injection Hepatitis A (inactivated) and hepatitis B(rDNA) (HAB) vaccine (adsorbed).
Twinrix za odrasle - suspenzija za injiciranje Cepivo proti hepatitisu A, inaktivirano, in hepatitisu B, rekombinantno (HAB), adsorbirano
Suspension for injection 1 vial 1 dose (1 ml)
Suspenzija za injiciranje 1 viala 1 odmerek (1 ml)
Suspension for injection 10 vials 10 x 1 dose 1 dose (1 ml)
Suspenzija za injiciranje 10 vial 10 x 1 odmerek 1 odmerek (1 ml)
Suspension for injection 25 vials 25 x 1 dose 1 dose (1 ml)
Suspenzija za injiciranje 25 vial 25 x 1 odmerek 1 odmerek (1 ml)
Suspension for injection 1 syringe 1 dose (1 ml)
Suspenzija za injiciranje 1 injekcijska brizga 1 odmerek (1 ml)
Suspension for injection 10 syringes 10 x 1 dose 1 dose (1 ml)
Suspenzija za injiciranje 10 injekcijskih brizg 10 x 1 odmerek 1 odmerek (1 ml)
Suspension for injection 25 syringes 25 x 1 dose 1 dose (1 ml)
Suspenzija za injiciranje 25 injekcijskih brizg 25 x 1 odmerek 1 odmerek (1 ml)
Suspension for injection 1 syringe 1 needle 1 dose (1 ml)
Suspenzija za injiciranje 1 injekcijska brizga 1 injekcijska igla 1 odmerek (1 ml)
Suspension for injection 10 syringes 10 needles 10 x 1 dose 1 dose (1 ml)
Suspenzija za injiciranje 10 injekcijskih brizg 10 injekcijskih igel 10 x 1 odmerek 1 odmerek (1 ml)
Suspension for injection 25 syringes 25 needles 25 x 1 dose 1 dose (1 ml)
Suspenzija za injiciranje 25 injekcijskih brizg 25 injekcijskih igel 25 x 1 odmerek 1 odmerek (1 ml)
39 MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
39 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA MANJŠIH STIČNIH OVOJNINAH
Twinrix Adult, suspension for injection HAB vaccine I. M.
Twinrix za odrasle, suspenzija za injiciranje HAB cepivo i. m.
Twinrix Adult, Suspension for injection Hepatitis A (inactivated) and hepatitis B(rDNA) (HAB) vaccine (adsorbed)
Twinrix za odrasle, suspenzija za injiciranje Cepivo proti hepatitisu A, inaktivirano, in hepatitisu B, rekombinantno (HAB), adsorbirano
What Twinrix Adult is and what it is used for 2.
Kaj je cepivo Twinrix za odrasle in za kaj ga uporabljamo 2.
Before you receive Twinrix Adult 3.
Kaj morate vedeti, preden boste cepljeni s cepivom Twinrix za odrasle 3.
How Twinrix Adult is given 4.
Kako se cepivo Twinrix za odrasle uporablja 4.
How to store Twinrix Adult 6.
Shranjevanje cepiva Twinrix za odrasle 6.
WHAT TWINRIX ADULT IS AND WHAT IT IS USED FOR
KAJ JE CEPIVO TWINRIX ZA ODRASLE IN ZA KAJ GA UPORABLJAMO
Twinrix Adult is a vaccine used in adults and adolescents 16 years of age and above to prevent two diseases: hepatitis A and hepatitis B.
Twinrix za odrasle je cepivo, ki se uporablja pri odraslih in mladostnikih, starih 16 let in več, za preprečevanje dveh bolezni: hepatitisa A in hepatitisa B.
The vaccine works by causing the body to produce its own protection (antibodies) against these diseases.
Cepivo deluje tako, da spodbudi telo k proizvajanju lastne zaščite (protiteles) proti tema boleznima.
Hepatitis A is an infectious disease, which can affect the liver.
Hepatitis A je nalezljiva bolezen, ki prizadene jetra.
This disease is caused by the hepatitis A virus.
To bolezen povzroča virus hepatitisa A.
The hepatitis A virus can be passed from person to person in food and drink, or by swimming in water contaminated by sewage.
Virus hepatitisa A se lahko z osebe na osebo prenaša s hrano in pijačo ali s plavanjem v vodi, onesnaženi s fekalijami.
After a few days the whites of eyes and skin may become yellowish (jaundice).
Po nekaj dneh lahko koža in/ ali beločnice postanejo rumenkaste barve (zlatenica).
Hepatitis B is caused by the hepatitis B virus.
Hepatitis B povzroča virus hepatitisa B.
It causes the liver to become swollen (inflamed).
Jetra otečejo (vnetje).
BEFORE YOU RECEIVE TWINRIX ADULT
KAJ MORATE VEDETI, PREDEN BOSTE CEPLJENI S CEPIVOM TWINRIX ZA ODRASLE
Twinrix Adult should not be given:
S cepivom Twinrix za odrasle ne smete biti cepljeni:
• if you have previously had any allergic reaction to Twinrix Adult, or any ingredient contained in this vaccine.
• če ste kdaj imeli alergijsko reakcijo na cepivo Twinrix za odrasle ali na katero koli sestavino tega cepiva.
The active substances and other ingredients in Twinrix Adult are listed at the end of the leaflet.
Zdravilne učinkovine in pomožne snovi cepiva Twinrix za odrasle so navedene na koncu tega navodila.
Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue. • if you have previously had an allergic reaction to any vaccine against hepatitis A and hepatitis B diseases. • if you have a severe infection with a high temperature (over 38°C).
Znaki alergijske reakcije lahko vključujejo srbeč kožni izpuščaj, težave z dihanjem (zasoplost) in zatekanje obraza ali jezika. • če ste kdaj imeli alergijsko reakcijo na katero koli drugo cepivo proti hepatitisu A ali hepatitisu B.
A minor infection such as a cold should not be a problem, but talk to your doctor first.
42 • če imate hujšo okužbo z visoko telesno temperaturo (višjo od 38 ˚C).
42 Take special care with Twinrix Adult:
Bodite posebno pozorni pri cepljenju s cepivom Twinrix za odrasle:
• if you have experienced any health problems after previous administration of a vaccine. • if you have a poor immune system due to illness or drug treatment. • if you have a bleeding problem or bruise easily.
• če ste po predhodnem cepljenju imeli kakršne koli zdravstvene težave. • če imate oslabel imunski sistem zaradi bolezni ali jemanja zdravil. • če imate težave s krvavitvami ali hitrim nastankom modric.
A poor response to the vaccine, possibly without achieving protection against hepatitis A, has been observed in obese people.
Pri osebah s prekomerno telesno maso so poročali o slabem odzivu na cepivo, tudi brez dosežene zaščite proti hepatitisu A.
A poor response to the vaccine, possibly without achieving protection against hepatitis B, has also been observed in older people, men rather than women, smokers, obese people, and people with long standing illnesses, or people on some type of drug treatments.
Slabši odziv na cepivo, tudi brez dosežene zaščite proti hepatitisu B, so opazili tudi pri starejših osebah, pogosteje pri moških kot pri ženskah, kadilcih, osebah s prekomerno telesno maso, osebah z dolgotrajnimi boleznimi ali osebah, ki jemljejo določena zdravila.
Using other medicines or vaccines Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or have recently received any other vaccine.
Svojega zdravnika obvestite tudi, če ste bili pred kratkim cepljeni s katerim koli drugim cepivom.
Pregnancy and breast-feeding Take special care with Twinrix Adult if you are or think you may be pregnant or if you intend to become pregnant.
Nosečnost in dojenje Če ste noseči, mislite da ste noseči ali nameravate zanositi, je potrebna pri cepljenju s cepivom Twinrix za odrasle še posebna previdnost.
Your doctor will discuss with you the possible risks and benefits of having Twinrix Adult during pregnancy.
O tveganjih in koristih cepljenja s cepivom Twinrix za odrasle med nosečnostjo se pogovorite s svojim zdravnikom.
Important information about some of the ingredients of Twinrix Adult Please tell your doctor if you have had an allergic reaction to neomycin (antibiotic).
Pomembne informacije o nekaterih sestavinah cepiva Twinrix za odrasle Obvestite svojega zdravnika, če ste kdaj imeli alergijsko reakcijo na neomicin (antibiotik).
HOW TWINRIX ADULT IS GIVEN
KAKO SE CEPIVO TWINRIX ZA ODRASLE UPORABLJA
Third dose:
prvi odmerek: drugi odmerek: tretji odmerek:
at an elected date 1 month later 6 months after the first dose
na izbrani dan 1 mesec pozneje 6 mesecev po prvem odmerku
A fourth dose is recommended at 12 months.
Cepljenje s četrtim odmerkom je priporočljivo dvanajst mesecev po cepljenju s prvem odmerkom.
Fourth dose:
prvi odmerek: drugi odmerek: tretji odmerek: četrti odmerek:
at an elected date 7 days later 21 days after the first dose 12 months after the first dose
na izbrani dan 7 dni pozneje 21 dni po prvem odmerku 12 mesecev po prvem odmerku
Your doctor will advise on the possible need for extra doses, and future booster dosing.
43 Vaš zdravnik vam bo svetoval v primeru, da bi potrebovali dodatne odmerke cepiva in kasnejše poživitvene odmerke.
Your doctor may advise you to have a blood test after you have completed the course of vaccinations to check if you
Vaš zdravnik vam lahko svetuje, da po prejemu vseh predvidenih odmerkov cepiva opravite krvne preiskave, da bi tako ugotovil, če je odziv na cepljenje zadovoljiv.
If you miss a scheduled injection, talk to your doctor and arrange a nother visit.
Če ste izpustili odmerek ob dogovorjenem času, se pogovorite z zdravnikom in se dogovorite za naslednji obisk.
Like all medicines, Twinrix Adult can cause side effects, although not everybody gets them.
Kot vsa zdravila ima lahko tudi cepivo Twinrix za odrasle neželene učinke, ki pa se ne pojavijo pri vseh cepljenih osebah.
Side effects that may occur are the following:
Pogosti (ki se pojavijo do 1 na 10 odmerkov cepiva): • Driska, navzea • Oteklina, pojav modric ali srbenja na mestu vboda • Splošno slabo počutje
Very common (These may occur in 1 in 10 doses or more of the vaccine): • Headache • Pain and redness at the injection site • Tiredness Common (These may occur in up to 1 in 10 doses of the vaccine): • Diarrhoea, nausea • Swelling, bruising or itching at the injection site • Generally feeling unwell Uncommon (These may occur in up to 1 in 100 doses of the vaccine): • Dizziness • Vomiting, stomach pain • Aching muscles • Upper respiratory tract infection • Fever equal to or greater than 37.5°C Rare (These may occur in up to 1 in 1,000 doses of the vaccine): • Swollen glands in the neck armpit or groin (lymphadenopathy) • Loss of skin sensitivity to pain or touch (hypoaesthesia) • Feeling of pins and needles (paraesthesia) • Rash, itching • Joint pain • Loss of appetite • Low blood pressure • Flu-like symptoms such as high temperature, sore throat, runny nose, cough and chills Very rare (These may occur in up to 1 in 10,000 doses of the vaccine):
Občasni (ki se lahko pojavijo do 1 na 100 odmerkov cepiva): • Omotica • bruhanje, bolečine v trebuhu • boleče mišice • Okužba zgornjih dihalnih poti • Zvišana telesna temperatura do 37. 5°C ali višja
Side effects occurred very rarely during clinical studies or routine use of the vaccine or with individual hepatitis A and hepatitis B vaccines include: • Reduction in blood platelets, which increases risk of bleeding or bruising (thrombocytopenia) • Purple or red brown spots visible through the skin(thrombocytopenic purpura) • Swelling or infection of the brain (encephalitis) • Degenerative disease of the brain (encephalopathy) • Inflammation of nerves (neuritis) • Numbness or weakness of the arms and legs (neuropathy), paralysis
Redki (ki se lahko pojavijo do 1 na 1000 odmerkov cepiva): • Povečane bezgavke na vratu, pod pazduho ali v dimljah (limfadenopatija) • Zmanjšana občutljivost za bolečino ali dotik (hipestezija) • Občutek mravljinčenja (parestezija) • Srbečica • Bolečina v sklepih • Izguba apetita • Nizek krvni tlak
44 • Fits or seizures • Swelling of the face, mouth or throat (angioneurotic oedema) • Purple or reddish-purple bumps on the skin (lichen planus), serious skin rashes (erythema multiforme), hives • Joint swelling, muscular weakness • Infection around the brain which may give severe headache with stiff neck and sensitivity to light (meningitis) • Inflammation of some blood vessels (vasculitis) • Serious allergic reactions (anaphylaxis, anaphylactoid reactions and mimicking serum sickness).
44 • Gripi podobni simtomi, kot so visoka telesna temperatura, vneto grlo, smrkavost, kašelj in mrzlica
Such reactions may occur before leaving the doctor’s surgery.
Take reakcije se lahko zgodijo preden zapustite ambulanto.
However, if you get any of these symptoms you should contact a doctor urgently. • Abnormal laboratory liver test results • Multiple sclerosis, swelling of the spinal cord (myelitis) • Drooping eyelid and sagging muscles on one side of the face (facial palsy) • A temporary inflammation of the nerves, causing pain, weakness and paralysis in the extremities and often progressing to the chest and face (Guillain-Barré syndrome) • A disease of the nerves of the eye (optic neuritis)
Nenormalne vrednosti preiskav jetrne funkcije • Multipla skleroza, oteklina hrbtenjače (mielitis) • Povešena veka in mlahave mišice na eni strani obraza (paraliza obraza) • Začasno vnetje živcev, ki povzročajo bolečino, šibkost in paralizo v ekstremitetah in često napredujejo proti prsnemu košu in obrazu (Guillain- Barré- jev sindrom) • Bolezen očesnih živcev (optični nevritis)
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Če kateri koli neželeni učinek postane resen, ali če opazite kateri koli neželen učinek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.
HOW TO STORE TWINRIX ADULT
SHRANJEVANJE CEPIVA TWINRIX ZA ODRASLE
Do not use Twinrix Adult after the expiry date which is stated on the carton.
Cepiva Twinrix za odrasle ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli.
What Twinrix Adult contains
Kaj vsebuje cepivo Twinrix za odrasle
3 Produced in yeast cells (Saccharomyces cerevisiae) by recombinant DNA technology 4
0, 05 miligrama Al3+ Adsorbiran na hidratirani aluminijev hidroksid 3 Pridobljen s tehnologijo rekombinantne DNA na celični kulturi kvasovk (Saccharomyces cerevisiae) 4 0, 4 miligrama Al3+ Adsorbiran na aluminijev fosfat
- The other ingredients in Twinrix Adult are: sodium chloride, water for injections.
- Pomožne snovi cepiva Twinrix za odrasle so: natrijev klorid in voda za injekcije.
45 Suspension for injection.
Suspenzija za injiciranje.
Rue de l’Institut 89 B-1330 Rixensart Belgium For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
Rue de l’ Institut 89 B- 1330 Rixensart Belgija
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47 ---------------------------------------------------------------------------------------------------------------------
The vaccine should be well shaken to obtain a slightly opaque, white suspension and visually inspected for any foreign particulate matter and/or variation of physical aspect prior to administration.
Pred uporabo morate cepivo dobro pretresti, da nastane rahlo motna bela suspenzija in ga vizualno pregledati glede morebitnih tujih delcev in/ ali odstopanja od fizikalnega videza.
Twinrix Adult, Suspension for injection in prefilled syringe Hepatitis A (inactivated) and hepatitis B(rDNA) (HAB) vaccine (adsorbed)
Twinrix za odrasle, suspenzija za injiciranje v napolnjeni injekcijski brizgi Cepivo proti hepatitisu A, inaktivirano, in hepatitisu B, rekombinantno (HAB), adsorbirano
A minor infection such as a cold should not be a problem, but talk to your doctor first.
49 • če imate hujšo okužbo z visoko telesno temperaturo (višjo od 38 ˚C).
48 Take special care with Twinrix Adult:
Bodite posebno pozorni pri cepljenju s cepivom Twinrix za odrasle:
Your doctor will advise on the possible need for extra doses, and future booster dosing.
50 Vaš zdravnik vam bo svetoval v primeru, da bi potrebovali dodatne odmerke cepiva in kasnejše poživitvene odmerke.
50 • Fits or seizures • Swelling of the face, mouth or throat (angioneurotic oedema) • Purple or reddish-purple bumps on the skin (lichen planus), serious skin rashes (erythema multiforme), hives • Joint swelling, muscular weakness • Infection around the brain which may give severe headache with stiff neck and sensitivity to light (meningitis) • Inflammation of some blood vessels (vasculitis) • Serious allergic reactions (anaphylaxis, anaphylactoid reactions and mimicking serum sickness).
Neželeni učinki se zelo redko pojavijo med kliničnimi študijami ali rutinskim cepljenjem cepivom Twinrix ali enovalentnim cepivom proti hepatitisu A ali hepatitisu B. • Znižanje števila krvnih ploščic (trombocitov), ki zviša tveganje za krvavitev ali pojav modric (trombocitopenija) • Rdeče ali rdečerjave lise, ki se vidijo skozi kožo (trombocitopenična purpura) • Oteklina ali okužba možganov (encefalitis) • Degenerativna bolezen možganov (encefalopatija) • Vnetje živcev (nevritis) • Otrplost ali šibkost rok in nog (nevropatija), paraliza • Krči ali napadi krčev • Oteklina obraza, ust ali grla (angionevrotični edem) • Škrlatne ali rdeče- škrlatne izbokline na koži (lihen planus), močan kožni izpuščaj (multiformni eritem), koprivnica • Oteklina sklepov, mišična slabost • Okužba okrog možganov, ki lahko povzroči hud glavobol z otrdelim vratom in občutljivostjo na svetlobo (meningitis) • Okužba nekaterih krvnih žil (vaskulitis) • Hude alergijske reakcije (anapflaksija, anafilaktoidna reakcija in serumski bolezni podobna reakcija).
51 Suspension for injection in prefilled syringe.
Suspenzija za injiciranje v napolnjeni injekcijski brizgi.
It contains inactivated (killed) hepatitis A viruses and parts of the hepatitis B virus as active substances.
Kot zdravilno učinkovino vsebuje inaktivirane (mrtve) viruse hepatitisa A in dele virusa hepatitisa B.
It is available in a 0.5 ml vial and in a 0.5 ml prefilled syringe.
Na voljo je v obliki 0, 5 ml vial in 0, 5 ml napolnjenih injekcijskih brizg.
Twinrix Paediatric contains small amounts of inactivated hepatitis A viruses and the ‘ surface antigen ’ (proteins from the surface) of the hepatitis B virus.
Zdravilo Twinrix Paediatric vsebuje majhne količine inaktiviranih virusov hepatitisa A in „ površinskih antigenov “ (beljakovin na površini) virusa hepatitisa B.
When a person is given the vaccine, the immune system recognises the viruses and surface antigens as ‘ foreign’ and makes antibodies against them.
Kadar oseba prejme cepivo, imunski sistem prepozna viruse in površinske beljakovine kot „ tuje “ ter začne proti njim tvoriti protitelesa.
The surface antigens of the hepatitis B virus are produced by a method known as ‘ recombinant DNA technology’: they are made by a yeast that has received a gene (DNA), which makes it able to produce the proteins.
Površinski antigeni virusa hepatitisa B se izdelujejo z metodo, ki se imenuje „ tehnologija rekombinantne DNA “: proizvajajo jih kvasovke, ki so prejele gen (DNA), zaradi katerega lahko tvorijo te beljakovine.