natgillin/translations-raw huggingface dataset:
excipients.
katero od pomožnih snovi.
13 Hepatic injury including elevated serum hepatic enzyme levels, hepatitis, autoimmune hepatitis and hepatic failure has been reported with interferon beta in post-marketing (see section 4.8).
13 V okviru postmarketinških izkušenj (glejte poglavje 4. 8) so pri uporabi interferona beta poročali o poškodbah jeter, vključno z zvišanimi vrednostmi jetrnih encimov v serumu, hepatitisom, avtoimunskim hepatitisom in jetrno odpovedjo.
Patients with cardiac disease, such as angina, congestive heart failure or arrhythmia, should be closely monitored for worsening of their clinical condition during treatment with AVONEX.
Bolnike s srčnimi boleznimi, kot so npr. angina pektoris, srčno popuščanje ali aritmija, je potrebno natančno opazovati, da se jim klinično stanje med zdravljenjem z zdravilom AVONEX ne poslabša.
Recent clinical studies with patients treated up to three years with AVONEX suggest that approximately 5% to 8% develop neutralising antibodies.
Nedavne klinične študije, pri katerih so se bolniki z zdravilom AVONEX zdravili do tri leta, kažejo, da približno 5% do 8% bolnikov razvije nevtralizirajoča protitelesa.
Women of child-bearing potential
14 Ženske v rodni dobi
If the patient becomes pregnant or plans to become pregnant while taking AVONEX she should be informed of the 14 potential hazards and discontinuation of therapy should be considered (see section 5.3).
Bolnice, ki načrtujejo nosečnost, in tiste, ki zanosijo, je potrebno seznaniti z možnimi nevarnostmi in zdravljenje z zdravilom AVONEX po potrebi prekiniti (glejte poglavje 5. 3).
No studies of the effects of AVONEX on the ability to drive and use machines have been performed.
Študij o vplivu zdravila AVONEX na sposobnost vožnje in upravljanja s stroji niso izvedli.
15 Investigations
15 Preiskave
16 Musculoskeletal and connective tissue disorders
16 Bolezni mišično- skeletnega sistema in vezivnega tkiva
flushing
navali vročine pogosti
General disorders and administration site conditions
Splošne težave in spremembe na mestu aplikacije zelo pogosti
very common
gripi podobni simptomi, pireksija2, mrzlica2, znojenje2
flu-like symptoms, pyrexia2, chills2, sweating2
bolečina na mestu injiciranja, eritem na pogosti
injection site pain, injection site erythema,
mestu injiciranja, podplutba na mestu injiciranja, astenija2, bolečina, utrujenost2, občutek neugodja, nočno znojenje
17 Hepatobiliary disorders
17 Bolezni jeter, žolčnika in žolčevodov
Some of these products have been 18 measured in the serum and cellular fractions of blood collected from patients treated with AVONEX.
Po enem samem
After a single intramuscular dose of AVONEX, serum levels of these products remain elevated for at least four days and up to one week.
18 intramuskularnem odmerku zdravila AVONEX so ostale ravni teh produktov v serumu dvignjene vsaj štiri dni in do enega tedna.
The effects of lyophilised AVONEX in the treatment of MS were demonstrated in a placebo-controlled study of 301 patients (AVONEX n=158, placebo n=143) with relapsing MS characterised by at least 2 exacerbations in the previous 3 years or at least one exacerbation per year prior to entry when the duration of the disease was less than 3 years.
Učinki zdravila AVONEX pri zdravljenju MS so bili prikazani v s placebom kontrolirani študiji, opravljeni na 301 bolniku (AVONEX n=158, placebo n=143) s ponavljajočo se multiplo sklerozo, ki so preteklih treh let doživeli vsaj dva povratna napada nevrološke disfunkcije (relapsa) ali vsaj enim zagonom na leto pred vstopom v študijo, ce je cas trajanja bolezni krajši od treh let.
Patients with an EDSS of 1.0 to 3.5 at entry were included in the clinical trial.
V klinicno študijo so bili vkljuceni bolniki, ki so pri vstopu v študijo imeli EDSS od 1 do 3, 5.
The estimated risk of a second event was 50% in three years and 39% in two years in the placebo group and 35% (three years) and 21% (two years) in the AVONEX group.
Ocenjeno tveganje drugega dogodka je bilo 50% v treh letih in 39% v dveh letih za bolnike, zdravljene s placebom, in 35% (tri leta) ter 21% (2 leti) za bolnike, zdravljene z zdravilom AVONEX.
19 5.3 Preclinical safety data
19 5. 3 Predklinični podatki o varnosti
In a 26-week repeated dose toxicity study in rhesus monkeys by intramuscular route once per week, administered in combination with another immunomodulating agent, an anti CD40 ligand monoclonal antibody, no immune response toward interferon beta-1a and no signs of toxicity were demonstrated.
Rezultati študije kažejo, da ni imunskega odziva na interferon beta- 1a, niti se niso pokazali znaki toksičnosti.
No teratogenic effects or effects on foetal development have been observed, but the available information on the effects of Interferon beta-1a in the peri- and postnatal periods is limited.
Teratogenih učinkov in vpliva na razvoj fetusa ni bilo moč opaziti, a informacije, ki so na voljo o učinkih interferona beta- 1a v perinatalnem in postnatalnem obdobju, so skope.
Sodium acetate trihydrate, Acetic acid, glacial, Arginine hydrochloride, Polysorbate 20, Water for injections.
Natrijev acetat trihidrat, koncentrirana ocetna kislina, argininijev klorid, polisorbat 20, voda za injekcije.
Store in a refrigerator (2 oC -8 oC).
Shranjujte v hladilniku (2 °C – 8 °C).
AVONEX can be stored at room temperature (between 15 oC and 30 oC) for up to one week.
AVONEX lahko do teden dni shranjujete pri sobni temperaturi (med 15 °C in 30 °C).
Store in the original package (sealed plastic tray) in order to protect from light (see section 6.5).
Shranjujte v originalni ovojnini (zaprt plastičen ovoj), za zagotovitev zaščite pred svetlobo (glejte poglavje 6. 5).
20 6.5 Nature and contents of container
20 6. 5 Vrsta ovojnine in vsebina
1 ml pre-filled syringe made of glass (Type I) with a tamper evident cap and plunger stopper (bromobutyl) containing 0.5 ml of solution.
1 ml napolnjena steklena injekcijska brizga (Tip I) s pokrovčkom, zapečatenim pred odpiranjem, in batnim zamaškom (bromobutil), ki vsebuje 0, 5 ml raztopine.
Pack size: box of four or twelve pre-filled syringes of 0.5 ml.
Velikost pakiranja: škatla s štirimi ali dvanajstimi napolnjenimi injekcijskimi brizgami po 0, 5 ml.
AVONEX is provided as ready to use solution for injection in a pre-filled syringe.
AVONEX je na voljo kot raztopina, pripravljena za injiciranje, v napolnjeni injekcijski brizgi.
Once removed from the refrigerator, AVONEX in a pre-filled syringe should be allowed to warm to room temperature (15 °C -30 °C) for about 30 minutes.
Ko zdravilo AVONEX postavite iz hladilnika, napolnjeno injekcijsko brizgo pustite zunaj približno 30 minut, da se segreje do sobne temperature (15 °C do 30 °C).
21 10.
21 DODATEK II
Detailed information on this medicinal product is available on the website of the European Medicines Agency (EMEA) http: / /www. emea. europa. eu
POGOJI DOVOLJENJA ZA PROMET Z ZDRAVILOM
Biogen Idec Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Biogen Idec Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, ZDA.
Biogen Idec Inc., 5000 Davis Drive, POB 14627, Research Triangle Park, North Carolina, 27709, USA.
Idec Inc., 5000 Davis Drive, POB 14627, Research Triangle Park, North Carolina, 27709, ZDA.
Biogen Idec B. V., Robijnlaan 8, 2132 WX Hoofddorp, The Netherlands.
BIOGEN IDEC B. V., Robijnlaan 8, 2132 WX Hoofddorp, Nizozemska.
Biogen Idec Denmark Manufacturing ApS, Biogen Idec Allé 1, DK-3400 Hillerød, Denmark.
Biogen Idec Denmark Manufacturing ApS, Biogen Idec Allé 1, DK- 3400 Hillerød, Danska.
LABELLING
25 PODATKI NA ZUNANJI OVOJNINI
BIO-SET PRESENTATION
BIO- SET PAKIRANJE
AVONEX 30 micrograms powder and solvent for solution for injection
AVONEX 30 mikrogramov prašek in vehikel za raztopino za injiciranje.
Interferon beta-1a
interferon beta- 1a
Each vial contains 30 micrograms (6 million IU) of interferon beta-1a.
Vsaka viala vsebuje 30 mikrogramov (6 milijonov i. e.) interferona beta - 1a.
Human serum albumin, sodium chloride, di- and monobasic sodium phosphate.
Humani serumski albumin, natrijev klorid, natrijev hidrogenfosfat in natrijev dihidrogenfosfat.
Packs of four doses presented as: vial with BIO-SET device containing medicinal product, pre-filled syringe of water for injections, one injection needle for intramuscular use.
Pakiranja s štirimi odmerki vsebujejo: vialo z BIO- SET nastavkom, ki vsebuje zdravilo, injekcijsko brizgo, napolnjeno z vodo za injekcije in eno iglo za intramuskularno uporabo.
For intramuscular use after reconstitution with solvent.
Za instramuskularno uporabo po rekonstituciji z vehiklom.
OTHER SPECIAL WARNING(S), IF NECESSARY
DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA 26 8.
Innovation House 70 Norden Road Maidenhead Berkshire SL6 4AY United Kingdom
Innovation House 70 Norden Road Maidenhead Berkshire SL6 4AY Velika Britanija
28 MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS
27 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
29 MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
28 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA MANJŠIH STIČNIH OVOJNINAH
AVONEX 30 micrograms powder for injection
AVONEX 30 mikrogramov prašek za raztopino za injiciranje
30 micrograms interferon beta-1a
30 mikrogramov interferona beta- 1a
30 MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
29 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA MANJŠIH STIČNIH OVOJNINAH
Solvent for reconstitution:
Vehikel za rekonstitucijo:
(1 ml pre-filled syringe)
(1 ml napolnjena injekcijska brizga)
31 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
30 PODATKI NA ZUNANJI OVOJNINI
AVONEX 30 micrograms/ 0.5 ml solution for injection
AVONEX 30 mikrogramov/ 0, 5 ml raztopina za injiciranje.
Each pre-filled syringe of 0.5 ml contains 30 micrograms (6 million IU) of interferon beta-1a.
Vsaka napolnjena 0, 5 ml injekcijska brizga vsebuje 30 mikrogramov (6 milijonov i. e.) interferona beta- 1a.
Sodium acetate trihydrate, acetic acid glacial, arginine hydrochloride, polysorbate 20, water for injections.
Natrijev acetat trihidrat, koncentrirana ocetna kislina, argininijev klorid, polisorbat 20, voda za injekcije.
Box of four pre-filled syringes of 0.5 ml of solution.
Škatla s štirimi napolnjenimi 0, 5 ml injekcijskimi brizgami raztopine.
Box of twelve pre-filled syringes of 0.5 ml of solution.
Škatla z dvanajstimi napolnjenimi 0, 5 ml injekcijskimi brizgami raztopine.
METHOD AND ROUTE (S) OF ADMINISTRATION
POSTOPEK IN POT( I) UPORABE ZDRAVILA
Avonex can be stored at room temperature (between 15 oC-30 oC) for up to one week.
AVONEX lahko do teden dni shranjujete pri sobni temperaturi (med 15 °C – 30 °C).
Store in the original package (sealed plastic tray) in order to protect from light.
Shranjujte v originalni ovojnini (zaprtem plastičnem ovoju), za zagotovitev zaščite pred svetlobo.
MARKETING AUTHORISATION NUMBER (S)
ŠTEVILKA( E) DOVOLJENJA (DOVOLJENJ) ZA PROMET
EU/ 1/ 97/ 033/ 003 4 pack EU/ 1/ 97/ 033/ 004 12 pack
EU/ 1/ 97/ 033/ 003 pakiranje po 4 EU/ 1/ 97/ 033/ 004 pakiranje po 12
34 MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS
33 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU ALI DVOJNEM TRAKU
AVONEX 30 micrograms/ 0.5 ml solution for injection
AVONEX 30 mikrogramov/ 0, 5 ml raztopina za injiciranje
Store in the original package (sealed plastic tray) in order to protect from light.
Shranjujte v originalni ovojnini (zaprtem plastičnem ovoju), za zagotovitev zaščitite pred svetlobo.
35 MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
34 PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA MANJŠIH STIČNIH OVOJNINAH
NAME OF THE MEDICINAL PRODUCT AND ROUTE (S) OF ADMINISTRATION
IME ZDRAVILA IN POT( I) UPORABE
PACKAGE LEAFLET
36 NAVODILO ZA UPORABO
AVONEX 30 micrograms powder and solvent for solution for injection (Interferon beta-1a) BIO-SET Presentation
AVONEX 30 mikrogramov prašek in vehikel za raztopino za injiciranje (interferon beta 1a) BIO- SET pakiranje
Even if you have used Avonex before, some of the information may have changed.
Tudi če ste Avonex že uporabljali, so se morda nekateri podatki spremenili.
- If you have any further questions, ask your doctor or your pharmacist
- Če imate dodatna vprašanja, se posvetujte z zdravnikom ali s farmacevtom.
- If any of the side effects gets serious, or if you notice any side effects not listed in this
- Če katerikoli neželeni učinek postane resen ali če opazite katerikoli neželeni učinek, ki ni omenjen
leaflet, please tell your doctor or pharmacist.
v tem navodilu, obvestite svojega zdravnika ali farmacevta.
Latest issue:
Zadnja izdaja:
{MM/ YYYY} This leaflet is changed from time to time.
{MM/ LLLL} To navodilo se občasno spreminja.
Before you use AVONEX 3.
Kaj morate vedeti, preden boste uporabili zdravilo AVONEX 3.
How to use AVONEX 4.
Kako uporabljati zdravilo AVONEX 4.
How to store AVONEX 6.
Shranjevanje zdravila AVONEX 6.
WHAT AVONEX IS AND WHAT IT IS USED FOR
KAJ JE ZDRAVILO AVONEX IN ZA KAJ GA UPORABLJAMO
The active ingredient in Avonex is a protein called interferon beta-1a.
Aktivna učinkovina v zdravilu Avonex je protein, ki se imenuje interferon beta- 1a.
Avonex is used to treat Multiple Sclerosis (MS).
Avonex se uporablja za zdravljenje multiple skleroze (MS).
- feeling off-balance or light headed, walking problems, stiffness and muscle spasms, tiredness,
- občutek neuravnoteženosti ali omotičnosti, težave pri hoji, togost in mišične krče, utrujenost,
numbness in the face, arms or legs
odrevenelost obraza, rok ali nog
- acute or chronic pain, bladder and bowel problems, sexual problems and problems seeing things
- akutne ali kronične bolečine, težave z mehurjem ali črevesjem, spolne težave in težave videti
- difficulty in thinking and concentrating, depression.
- težave v razmišljanju in osredotočenju, depresijo.
38 (Notes information)
37 (Opomba)
Do not stop your Avonex treatment without speaking to your neurologist.
Preden prenehate zdravljenje z zdravilom Avonex, se posvetujte s svojim nevrologom.
Avonex can help to reduce the number of relapses that you have and slow down the disabling effects of MS.
Avonex lahko pomaga zmanjšati število ponovitev, ki jih imate, in upočasniti onesposobljujoče učinke MS.
Multiple sclerosis is linked to nerve (brain or spinal cord) damage.
Multipla skleroza je povezana s poškodovanimi živci (možganskimi ali živci hrbtenjače).
In MS, your body’ s defence system reacts against it’ s own myelin – the ‘ insulation ’ that surrounds nerve fibres.
Pri MS se obrambni sistem telesa odzove na lastni mielin – „ izolacijo “, ki obdaja živčna vlakna.
Avonex seems to work by stopping your body’ s defence system from attacking the myelin.
Kaže, da deluje Avonex tako, da ustavi obrambni sistem vašega telesa, da bi napadel mielin.
BEFORE YOU USE AVONEX
KAJ MORATE VEDETI, PREDEN BOSTE UPORABILI ZDRAVILO AVONEX
Do not use AVONEX
Ne uporabljajte zdravila AVONEX
- if you are allergic (hypersensitive) to interferon beta, human serum albumin or any of the
- če ste alergični na (preobčutljivi za) interferon beta, človeški serumski albumin ali katero koli
other ingredients in Avonex
drugo sestavino zdravila Avonex,
- if you are pregnant, do not start using Avonex
- če ste noseči, ne začnite z uporabo zdravila Avonex,
- if you have severe depression or think about committing suicide.
- če imate hudo depresijo ali če razmišljate o samomoru.
Talk to a doctor straight away if any of these apply to you.
Če karkoli od tega velja za vas, se pogovorite s svojim zdravnikom.
Avonex and allergic reactions.
Avonex in alergijske reakcije.
Because Avonex is based on a protein, there is a small chance of an allergic reaction.
Ker temelji zdravilo Avonex na proteinu, je možnost alergijskih reakcij majhna.
If you have depression, your doctor may still prescribe Avonex for you, but it's important to let your doctor know if you have had depression or any similar problems affecting your moods.
Če imate depresijo, vam lahko zdravnik sicer predpiše Avonex, vendar je pomembno, da zdravnika obvestite, če ste imeli depresije ali podobne težave, ki vplivajo na razpoloženje.
Take special care with AVONEX
Bodite posebno pozorni pri uporabi zdravila AVONEX
If you have or have had in the past:
Najprej se pogovorite z zdravnikom, če imate ali ste v preteklosti imeli:
- depression or problems affecting your moods
- depresijo ali težave, ki vplivajo na razpoloženje
- thoughts about committing suicide.
- razmišljanja, da bi naredili samomor
- epilepsy or other seizure disorders not controlled by medication
- epilepsijo ali druge oblike napadov, ki jih ni možno nadzorovati z zdravili
- serious kidney or liver problems
- resne težave z ledvicami ali jetri
- a low number of white blood cells or platelets, which can cause an increased risk of infection,
- majhno število levkocitov ali trombocitov, kar lahko poviša tveganje okužb, krvavitev ali
bleeding or anaemia
slabokrvnosti
- heart problems, which can cause symptoms such as chest pain (angina), particularly after any
- težave s srcem, ki lahko povzročijo simptome, kot so bolečine v prsih (angina pektoris), še
activity; swollen ankles, shortness of breath (congestive heart failure); or an irregular heartbeat (arrhythmias).
zlasti po kakršnikoli aktivnosti; otekle gležnje, krastko sapo (kongestivna srčno popuščanje); ali neenakomeren srčni utrip (aritmije).
Talk to your doctor if you have any of these conditions, or if they worsen whilst taking Avonex.
Če imate katero od teh stanj ali če se z uporabo zdravila Avonex poslabša, se posvetujte z zdravnikom.
Tell your doctor you are using AVONEX:
Povejte zdravniku, da uporabljate zdravilo AVONEX:
- if you are having a blood test.
- če vam bodo naredili krvni test.
Avonex may interfere with the results.
Avonex lahko vpliva na rezultate.
For example, if you are prescribed other medicines, or if you have a blood test, Avonex may affect the other medicines or the test result.
Na primer, če vam predpisujejo zdravila, ali če izvajajo krvni test, lahko Avonex vpliva na druga zdravila ali rezultat testa.
If you are using other medicines, especially those used to treat epilepsy or depression.
če jemljete druga zdravila, še zlasti tista za zdravljenje epilepsije ali depresije.
Avonex may affect other medicines or be affected by them.
Avonex lahko vpliva na druga zdravila ali druga zdravila vplivajo nanj.
- If you could get pregnant, you need to use contraception while you use Avonex.
- Če bi lahko zanosili, morate med jemanjem zdravila AVONEX uporabljati kontracepcijo.
- If you are planning a baby or if you become pregnant while you are using Avonex, tell your
- Če načrtujete, da bi imeli otroka ali če zanosite, medtem ko uporabljate AVONEX, se morate
doctor.
posvetovati z zdravnikom.
- If you are already pregnant, or think that you might be, talk to a doctor as soon as you can.
- Če ste že noseči ali mislite, da bi lahko bili, se nemudoma posvetujte s svojim zdravnikom.
- If you want to breastfeed talk to your doctor first.
- Če želite dojiti, se najprej posvetujte s svojim zdravnikom.
Avonex makes some people feel dizzy.
Avonex povzroča vrtoglavico pri nekaterih bolnikih.
If this happens to you, or if you get any other side effects that could affect your ability, do not drive or use machines.
Če ste tudi vi med prizadetimi in ali če čutite druge neželene učinke, ki bi lahko vplivali na vašo sposobnost, ne vozite in ne upravljajte strojev.
This medicine is essentially ‘ sodium-free’.
Zdravilo je pravzaprav » brez natrija «.
HOW TO USE AVONEX
KAKO UPORABLJATI ZDRAVILO AVONEX
The usual dose for adults and adolescents aged 12 years and over
Običajni odmerek za odrasle in mladostnike, stare 12 let in več
Not for children Avonex is not to be used in children below the age of 12 years.
Ne uporabljajte za otroke Zdravilo Avonex se ne sme uporabiti pri otrocih, starih manj kot 12 let.
40 Injecting yourself
39 Navodila za samoinjiciranje
If you have trouble handling the syringe, ask your doctor who may be able to help.
Če imate težave pri rokovanju z injekcijsko brizgo, se posvetujte s svojim zdravnikom, ki vam bo lahko pomagal.
If you have problems handling the syringe, talk to your doctor about using a syringe grip.
Če imate težave z rokovanjem injekcijske brizge, se pogovorite z zdravnikom glede uporabe ročaja za injekcijsko brizgo.
This is a specially designed holder to help you with injecting Avonex.
To je posebej zasnovano držalo, ki vam bo v pomoč ob injiciranju zdravila Avonex.
If you have used more than one injection of Avonex in a three-day period, contact your doctor or pharmacist straight away for advice.
Če ste si injicirali več kot eno injekcijo zdravila Avonex v obdobju treh dni, se nemudoma posvetujte s svojim zdravnikom ali s farmacevtom.
Then leave a week before using Avonex again.
Nato počakajte en teden, preden ponovno uporabite Avonex.
If you have a preferred day for using Avonex, talk to your doctor about managing the dose, to get back to your preferred day.
Če imate dan, na katerega najraje uporabljate Avonex, se z zdravnikom pogovorite o načinu odmerjanja, ki bi omogočil vrnitev na dan, ki ste si ga določili.
Like all medicines, Avonex can cause side effects, although not everyone gets them.
Kot vsa zdravila lahko tudi zdravilo Avonex povzroči neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
Although the list of possible side effects can seem worrying, it ’ s possible that you may not have any of them.
Čeprav je seznam vseh možnih neželenih učinkov zaskrbljujoč, morda ne boste imeli niti enega.
Serious side effects: get medical help
40 Resni neželeni učinki: poiščite zdravniško pomoč
41 Serious allergic reactions If you get any of these:
Resne alergijske reakcije Če se pojavi:
- swelling of the face, lips or tongue
- oteklost obraza, ustnic ali jezika
- difficulty breathing
- težave pri dihanju
- a rash.
- izpuščaj.
Depression If you get any symptoms of depression:
Depresija Če se pojavijo naslednji simptomi depresije:
- feeling unusually sad, anxious or worthless.
- občutek neobičajne žalosti, zaskrbljenosti ali ničvrednosti.
Liver problems If you get any of these symptoms:
Težave z jetri Če se pojavijo kateri od naslednjih simptomov:
- yellowing of your skin or the whites of your eyes (jaundice)
- porumenelost kože ali beločnice (zlatenica)
- itching all over
- splošno srbenje
- feeling sick, being sick (nausea and vomiting)
- občutek slabosti, slabost (navzea ali bruhanje)
- easy bruising of the skin.
- nagnjenost k modricam na koži.
The figures are based on how many people said they’ d had them.
Številke temeljijo na izjavah ljudi, ki so trdili, da so jih imeli.
Very common side effects (at least 1 in 10 people are affected)
Zelo pogosti neželeni učinki (prizadet je vsaj 1 od 10 ljudi)
- flu-like symptoms – headache, muscle aches, chills or a fever: see Flu-like symptoms, below
glejte Gripi podobni simptomi, spodaj
Common side effects (less than 1 in 10 people are affected)
Pogosti neželeni učinki (prizadeta je manj kot 1 od 10 oseb)
- loss of appetite
- izguba apetita
- feeling weak and tired
- občutek šibkosti in utrujenosti
- difficulty sleeping
- težave pri spanju
- depression
- depresija
- flushing
- navali vročine
- runny nose
- izcejanje iz nosu
- diarrhoea (loose stools)
- driska (mehka stolica)
- feeling or being sick (nausea or vomiting)
- občutek slabosti ali slabost (navzea ali bruhanje)
- numbness or tingling of skin
- odrevenelost ali skelenje kože
- rash, bruising of the skin
- izpuščaj, nagnjenost k modricam
- increased sweating, night sweats
- povečano znojenje, nočno znojenje
- pain in your muscles, joints, arms, legs or neck
- bolečine v mišicah, sklepih, rokah, nogah ali v vratu
- muscle cramps, stiffness in the joints and muscles
- mišični krči, togost sklepov in mišic
- pain, bruising and redness at the injection site
- bolečina, modrica in pordelost na mestu injiciranja
- changes to blood tests.
- spremembe krvnih testov.
Symptoms you might notice are tiredness, repeated infection,
Simptomi, ki jih boste morda opazili, so utrujenost, ponavljajoče se
unexplained bruising or bleeding.
okužbe, nepojasnjeno nastajanje modric ali krvavitve.
42 Uncommon side effects (less than 1 in 100 people affected)
Občasni neželeni učinki (prizadetih je manj kot 1 od 100 ljudi)
- hair loss
- izpadanje las
- changes to your monthly period
- spremembe v menstrualnem ciklu
- burning feeling at the site of injection.
- žgoč občutek na mestu injiciranja.