natgillin/translations-raw huggingface dataset:
Renal impairment No dosage adjustment of Exforge is required for patients with mild to moderate renal impairment (GFR > 30 ml/ min/ 1.73 m2).
15 Okvara ledvic Pri bolnikih z blago do zmerno okvaro ledvic (hitrost glomerulne filtracije > 30 ml/ min/ 1, 73 m2) odmerka zdravila Exforge ni treba prilagajati.
There is no experience on the use of Exforge in pregnant women.
17 Z uporabo zdravila Exforge pri nosečnicah ni izkušenj.
Animal studies indicate that the valsartan/ amlodipine has reproductive toxicity in line with what has been described for valsartan and
Študije na živalih kažejo, da ima kombinacija valsartan/ amlodipin reproduktivne toksične učinke, ki se skladajo z učinki, opisanimi za valsartan in druge antagoniste angiotenzina II (glejte poglavje 5. 3).
Exforge 10 mg/ 160 mg film-coated tablets
Exforge 10 mg/ 160 mg filmsko obložene tablete
Exforge 10 mg/ 160 mg may be administered in patients whose blood pressure is not adequately controlled with amlodipine 10 mg or valsartan 160 mg alone or with Exforge 5 mg/ 160 mg.
Exforge 10 mg/ 160 mg lahko uporabite pri bolnikih, pri katerih krvni tlak ni ustrezno urejen samo z 10 mg amlodipina ali s 160 mg valsartana ali s kombinacijo Exforge 5 mg/ 160 mg.
26 Children and adolescents Exforge is not recommended for use in patients aged below 18 years due to a lack of data on safety and efficacy.
26 Otroci in mladostniki Zaradi pomanjkanja podatkov o varnosti in učinkovitosti zdravila Exforge ni priporočljivo uporabljati pri bolnikih, mlajših od 18 let.
Renal impairment No dosage adjustment of Exforge is required for patients with mild to moderate renal impairment (GFR > 30 ml/ min/ 1.73 m2).
27 Okvara ledvic Pri bolnikih z blago do zmerno okvaro ledvic (hitrost glomerulne filtracije > 30 ml/ min/ 1, 73 m2) odmerka zdravila Exforge ni treba prilagajati.
There is no experience on the use of Exforge in pregnant women.
29 Z uporabo zdravila Exforge pri nosečnicah ni izkušenj.
General disorders and administration site conditions
30 Splošne težave in spremembe na mestu aplikacije
Oedema, pitting oedema, facial oedema, oedema peripheral, fatigue, flushing, 30
edemi, testasti edemi, edem obraza, periferni edemi, utrujenost, zardevanje, astenija, navali vročine
asthenia, hot flush Immune system disorders
Bolezni imunskega sistema
Additional information on the individual components Adverse drug reactions previously reported with one of the individual components (amlodipine or valsartan) may be potential undesirable effects with Exforge as well, even if not observed in clinical trials or during the post-marketing period.
Dodatne informacije o posameznih zdravilnih učinkovinah Neželeni učinki, opisani za katero od obeh zdravilnih učinkovin (za amlodipin ali valsartan), so lahko tudi neželeni učinki zdravila Exforge, tudi če niso bili ugotovljeni v kliničnih preskušanjih ali v obdobju po prihodu tega zdravila na trg.
Arrhythmia, myocardial infarction, Rarely, patients, particularly those with severe obstructive coronary artery disease, have developed increased frequency, duration or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dosage increase.
Redko je pri bolnikih, posebno pri tistih s hudo obstruktivno koronarno boleznijo, prišlo do zvečanja pogostnosti, trajanja ali izraženosti angine pektoris ali akutnega miokardnega infarkta ob začetku zdravljenja z zaviralcem kalcijevih kanalčkov ali ob zvečanju odmerka.
Exforge 5 mg/ 80 mg film-coated tablets amlodipine/ valsartan
Exforge 5 mg/ 80 mg filmsko obložene tablete amlodipin/ valsartan
Exforge 5 mg/ 160 mg film-coated tablets amlodipine/ valsartan
Exforge 5 mg/ 160 mg filmsko obložene tablete amlodipin/ valsartan
Exforge 10 mg/ 160 mg film-coated tablets amlodipine/ valsartan
Exforge 10 mg/ 160 mg filmsko obložene tablete amlodipin/ valsartan
What Exforge is and what it is used for 2.
Kaj je zdravilo Exforge in za kaj ga uporabljamo 2.
Before you take Exforge 3.
Kaj morate vedeti, preden boste vzeli zdravilo Exforge 3.
How to take Exforge 4.
Kako jemati zdravilo Exforge 4.
How to store Exforge 6.
Shranjevanje zdravila Exforge 6.
WHAT EXFORGE IS AND WHAT IT IS USED FOR
KAJ JE ZDRAVILO EXFORGE IN ZA KAJ GA UPORABLJAMO
Exforge tablets contain two substances called amlodipine and valsartan.
Tablete Exforge vsebujejo dve učinkovini: amlodipin in valsartan.
Exforge is used to treat high blood pressure in patients whose blood pressure is not controlled enough with either amlodipine or valsartan on its own.
Zdravilo Exforge uporabljamo za zdravljenje visokega krvnega tlaka pri bolnikih, pri katerih krvni tlak ni dovolj dobro urejen samo z amlodipinom ali samo z valsartanom.
BEFORE YOU TAKE EXFORGE
KAJ MORATE VEDETI, PREDEN BOSTE VZELI ZDRAVILO EXFORGE
Do not take Exforge − if you are allergic (hypersensitive) to amlodipine or other medicines of the dihydropyridine type, − if you are allergic (hypersensitive) to valsartan or any of the other ingredients of Exforge.
Ne jemljite zdravila Exforge − če ste alergični na (preobčutljivi za) amlodipin ali kakšno drugo zdravilo dihidropiridinske vrste − če ste alergični na (preobčutljivi za) valsartan ali katerokoli sestavino zdravila Exforge.
If you think you may be allergic, talk to your doctor before taking Exforge. − if you have severe liver problems, such as biliary cirrhosis or cholestasis. − if you have severe kidney problems or if you are having dialysis. − during the last 6 months of pregnancy, see “ Pregnancy and breastfeeding”.
Če domnevate, da bi lahko bili alergični, se posvetujte z zdravnikom, preden vzamete zdravilo Exforge. − če imate hude težave z jetri, npr. biliarno cirozo ali holestazo. − če imate hude težave z ledvicami ali se zdravite z dializo. − v zadnjih 6 mesecih nosečnosti, glejte poglavje "Nosečnost in dojenje".
64 Take special care with Exforge − if you have been sick (vomiting or diarrhoea). − if you are taking diuretics (a type of medicine also called “ water tablets” which increases the amount of urine you produce). − if you are taking other medicines or substances that increase the level of potassium in your blood (e. g. some types of diuretics, potassium supplements or salt substitutes containing potassium). − if you have liver or kidney problems. − if you have a condition affecting the renal glands called “ primary hyperaldosteronism”. − if you have had heart failure. − if your doctor has told you that you have a narrowing of the valves in your heart (called “ aortic or mitral stenosis”) or that the thickness of your heart muscle is abnormally increased (called “ obstructive hypertrophic cardiomyopathy”).
64 − če jemljete druga zdravila ali učinkovine, ki zvišujejo koncentracijo kalija v krvi (npr. nekatere vrste diuretikov, dodatki kalija ali nadomestki soli, ki vsebujejo kalij). − če imate težave z jetri ali ledvicami. − če imate posebno bolezen nadledvičnih žlez, imenovano “ primarni hiperaldosteronizem ”. − če ste kdaj imeli srčno popuščanje. − če vam je zdravnik povedal, da imate zožene srčne zaklopke (t. i. aortno ali mitralno stenozo) ali nenormalno zadebeljeno srčno mišico (t. i. obstruktivno hipertrofično kardiomiopatijo).
If any of these apply to you, tell your doctor before taking Exforge.
Če kaj od naštetega velja za vas, morate to povedati zdravniku, preden vzamete Exforge.
Exforge is not recommended in early pregnancy and may cause serious harm to your baby if taken after 3 months of pregnancy (see section “ Pregnancy and breast-feeding”).
Uporaba zdravila Exforge ni priporočljiva v zgodnjem obdobju nosečnosti, po tretjem mesecu nosečnosti pa lahko povzroči resno škodo vašemu otroku (glejte poglavje "Nosečnost in dojenje").
The use of Exforge in children and adolescents is not recommended.
Zdravila Exforge ni priporočljivo uporabljati pri otrocih in mladostnikih.
Taking Exforge with food and drink You can take Exforge with or without food.
Jemanje zdravila Exforge skupaj s hrano in pijačo Zdravilo Exforge lahko vzamete s hrano ali brez nje.
Exforge and older people Caution is required when increasing the dosage.
Zdravilo Exforge in starejši bolniki Pri večanju odmerka je potrebna previdnost.
Usually, your doctor will advise you to take another medicine instead of Exforge, as Exforge is not recommended in early pregnancy, and may cause serious harm to your baby if it is used after 3 months of pregnancy.
Zdravnik vam bo praviloma svetoval jemanje drugega zdravila namesto zdravila Exforge, saj jemanje zdravila Exforge v zgodnjem obdobju nosečnosti ni priporočljivo in lahko po tretjem mesecu nosečnosti povzroči resno škodo vašemu otroku.
An appropriate antihypertensive medication must usually replace Exforge before starting a pregnancy.
V primeru načrtovanja nosečnosti je treba praviloma preiti na drugo vrsto zdravljenja proti zvišanemu krvnemu tlaku.
The product should not be used during the second and third trimesters of pregnancy.
Zdravila Exforge ne smete jemati v drugem in tretjem trimesečju nosečnosti.
Your doctor will normally advise you to stop taking Exforge as soon as you know you are pregnant.
Zdravnik vam bo praviloma svetoval, da prekinete z jemanjem zdravila Exforge takoj, ko izveste, da ste noseči.
If you become pregnant during therapy with Exforge, please inform and see your doctor without delay.
Če zanosite med zdravljenjem z zdravilom Exforge takoj obvestite svojega zdravnika.
Treatment with Exforge is not recommended during breast- feeding.
Zdravljenje z zdravilom Exforge med obdobjem dojenja ni priporočljivo.
HOW TO TAKE EXFORGE
KAKO JEMATI ZDRAVILO EXFORGE
Always take this medicine exactly as your doctor has told you.
Pri jemanju zdravila Exforge natančno upoštevajte zdravnikova navodila.
The usual dose of Exforge is one tablet per day. − It is advisable to take your medicine at the same time each day, preferably in the morning. − Swallow the tablets with a glass of water. − You can take Exforge with or without food.
Običajni odmerek zdravila Exforge je ena tableta na dan. − Priporočljivo je, da vzamete zdravilo vsak dan ob istem času, najbolje zjutraj. − Tablete zaužijte s kozarcem vode. − Zdravilo Exforge lahko vzamete s hrano ali brez nje.
If you take more Exforge than you should If you have taken too many tablets of Exforge, or if someone else has taken your tablets, consult a doctor immediately.
Če ste vzeli večji odmerek zdravila Exforge, kot bi smeli Če ste vzeli preveč tablet zdravila Exforge, ali je vaše tablete vzel kdo drug, se takoj posvetujte z zdravnikom.
If you forget to take Exforge If you forget to take this medicine, take it as soon as you remember.
Če ste pozabili vzeti zdravilo Exforge Če ste pozabili vzeti zdravilo, ga vzemite, takoj ko se spomnite.
Like all medicines, Exforge can cause side effects, although not everybody gets them.
Kot vsa zdravila ima lahko tudi zdravilo Exforge neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
HOW TO STORE EXFORGE
SHRANJEVANJE ZDRAVILA EXFORGE
What Exforge contains − The active substances of Exforge are amlodipine (as amlodipine besylate) and valsartan.
Kaj vsebuje zdravilo Exforge − Zdravilni učinkovini v zdravilu Exforge sta amlodipin (v obliki amlodipinijevega besilata) in valsartan.
What Exforge looks like and contents of the pack Exforge 5 mg/ 80 mg tablets are round and dark yellow with “ NVR” on one side and “ NV” on the other side.
Izgled zdravila Exforge in vsebina pakiranja Tablete Exforge 5 mg/ 80 mg so okrogle in temnorumene; na eni strani imajo oznako “ NVR ” in na drugi “ NV ”.
Exforge is available in packs containing 7, 14, 28, 30, 56, 90, 98 or 280 tablets and in multipacks comprising 4 cartons, each containing 70 tablets.
Zdravilo Exforge je na voljo v pakiranjih, ki vsebujejo 7, 14, 28, 30, 56, 90, 98 ali 280 tablet in v skupnih pakiranjih s 4 škatlami, od katerih vsaka vsebuje 70 tablet.
Tél/ Tel: +32 2 246 16 11
Tel: +49 911 273 0 Tél/ Tel: +32 2 246 16 11
Luxembourg/ Luxemburg Novartis Pharma GmbH Tél/ Tel: +49 911 273 0
Magyarország България Novartis Hungária Kft.
България Novartis Pharma Services Inc.
Pharma Novartis Pharma Services Inc.
Тел.: +359 2 976 98 28
Tel.: +36 1 457 65 00 Тел.: +359 2 976 98 28
Pharma Tel.: +36 1 457 65 00
Malta Česká republika Novartis Pharma Services Inc.
Č eská republika Novartis s. r. o.
Novartis s. r. o.
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Tel: +356 2298 3217 Tel: +420 225 775 111
Norge Novartis Norge AS Tlf: +47 23 05 20 00
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Tel: +34 93 306 42 00
68 Portugal España Novartis Farma - Produtos Farmacêuticos, S. A.
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United Kingdom Latvija Novartis Pharmaceuticals UK Ltd.
Tel: +371 7 887 070
Tel: +44 1276 698370 Tel: +371 7 887 070
70 Take special care with Exforge − if you have been sick (vomiting or diarrhoea). − if you are taking diuretics (a type of medicine also called “ water tablets” which increases the amount of urine you produce). − if you are taking other medicines or substances that increase the level of potassium in your blood (e. g. some types of diuretics, potassium supplements or salt substitutes containing potassium). − if you have liver or kidney problems. − if you have a condition affecting the renal glands called “ primary hyperaldosteronism”. − if you have had heart failure. − if your doctor has told you that you have a narrowing of the valves in your heart (called “ aortic or mitral stenosis”) or that the thickness of your heart muscle is abnormally increased (called “ obstructive hypertrophic cardiomyopathy”).
70 − če jemljete druga zdravila ali učinkovine, ki zvišujejo koncentracijo kalija v krvi (npr. nekatere vrste diuretikov, dodatki kalija ali nadomestki soli, ki vsebujejo kalij). − če imate težave z jetri ali ledvicami. − če imate posebno bolezen nadledvičnih žlez, imenovano “ primarni hiperaldosteronizem ”. − če ste kdaj imeli srčno popuščanje. − če vam je zdravnik povedal, da imate zožene srčne zaklopke (t. i. aortno ali mitralno stenozo) ali nenormalno zadebeljeno srčno mišico (t. i. obstruktivno hipertrofično kardiomiopatijo).
73 − The other ingredients are cellulose microcrystalline; crospovidone type A; silica, colloidal anhydrous; magnesium stearate; hypromellose; macrogol 4000; talc, titanium dioxide (E171); iron oxide, yellow (E172).
73 − Pomožne snovi so mikrokristalna celuloza, krospovidon tipa A, brezvoden koloidni silicijev dioksid, magnezijev stearat, hipromeloza, makrogol 4000, smukec, titanov dioksid (E171), rumeni železov oksid (E172).
What Exforge looks like and contents of the pack Exforge 5 mg/ 160 mg tablets are oval and dark yellow “ NVR” on one side and “ ECE” on the other side.
Izgled zdravila Exforge in vsebina pakiranja Tablete Exforge 5 mg/ 160 mg so ovalne in temnorumene; na eni strani imajo oznako “ NVR ” in na drugi “ ECE ”.
Luxembourg/ Luxemburg Novartis Pharma GmbH Tel: +49 911 273 0
Magyarország България Novartis Hungária Kft.
Tel: +34 93 306 42 00
74 Portugal España Novartis Farma - Produtos Farmacêuticos, S. A.
Take special care with Exforge − if you have been sick (vomiting or diarrhoea).
Bodite posebno pozorni pri uporabi zdravila Exforge − če vam je bilo slabo (bruhanje ali driska). − če jemljete diuretike (zdravila, ki jim pravimo tudi “ zdravila za odvajanje vode ” in povečajo količino izločenega urina).
Dizziness; nausea and abdominal pain; dry mouth; drowsiness, tingling or numbness of the hands or feet; vertigo; fast heart beat including palpitations; dizziness on standing up; cough; diarrhoea; constipation; skin rash, redness of the skin; joint swelling, back pain; pain in joints.
Občasni (pojavijo se pri manj kot 1 od 100 bolnikov): omotica; slabost v želodcu in bolečine v trebuhu; suhost ust; zaspanost, mravljinčenje ali omrtvelost dlani in stopal; vrtoglavica; hitro bitje srca, vključno s palpitacijami; omotičnost stoje; kašelj; driska; zaprtje; osip, pordelost kože; oteklost sklepov, bolečine v hrbtu; bolečine v sklepih.
Feeling anxious; ringing in the ears (tinnitus); fainting; passing more urine than normal or feeling more of an urge to pass urine; inability to get or maintain an erection; sensation of heaviness; low blood pressure with symptoms such as dizziness, light- headedness; excessive sweating; skin rash all over your body; itching; muscle spasm.
Redki (pojavijo se pri manj kot 1 od 1. 000 bolnikov): občutek tesnobe; zvonjenje v ušesih (tinitus); omedlevica; izločanje več urina kot ponavadi ali pogostejše siljenje na vodo; nezmožnost za doseganje ali ohranitev erekcije; občutek teže; nizek krvni tlak s simptomi, kot sta omotica in vrtoglavost; čezmerno znojenje; osip po koži po vsem telesu; srbenje; mišični krči.
78 If any of these affect you severely, tell your doctor.
78 Če se karkoli od naštetega pri vas pojavi v hudi obliki, morate to povedati zdravniku.
79 What Exforge looks like and contents of the pack Exforge 10 mg/ 160 mg tablets are oval and light yellow with “ NVR” on one side and “ UIC” on the other side.
Izgled zdravila Exforge in vsebina pakiranja Tablete Exforge 10 mg/ 160 mg so ovalne in svetlorumene; na eni strani imajo oznako “ NVR ” in na drugi “ UIC ”.
Tel: +34 93 306 42 00
80 Portugal España Novartis Farma - Produtos Farmacêuticos, S. A.
CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT TO BE IMPLEMENTED BY THE MEMBER STATES
POGOJI ALI OMEJITVE V ZVEZI Z VARNO IN UČINKOVITO UPORABO ZDRAVILA, KI JO MORA IZPOLNITI DRŽAVA ČLANICA
1 • CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT TO BE IMPLEMENTED BY THE MEMBER STATES
1 • POGOJI ALI OMEJITVE V ZVEZI Z VARNO IN UČINKOVITO UPORABO ZDRAVILA, KI JO MORA IZPOLNITI DRŽAVA ČLANICA
The Member States shall ensure that in their Member State:
Država članica naj v svoji državi zagotovi naslednje:
Product information Physician information about Exjade (brochure and pocket card) Patient information pack
Podatke o zdravilu Podatke o zdravilu Exjade za zdravnika (knjižico in kartonček) Komplet podatkov o zdravilu za bolnika
• That Exjade causes rises in serum creatinine in some patients o The need to monitor serum creatinine • On two occasions prior to initiation of treatment • Every week during the first month of initiation of treatment or after modification of therapy • Monthly thereafter o The need to reduce by 10 mg/ kg the dose if serum creatinine rises: • Adults: > 33% above baseline and creatinine clearance< LLN (90 ml/min) • Paediatrics: either > ULN or creatinine clearance falls to < LLN o The need to interrupt treatment if serum creatinine rises: • Adults and paediatrics: > 33% above baseline or creatinine clearance < LLN (90 ml/min) o The need to consider renal biopsy: • When serum creatinine is elevated and if another abnormality has been detected (eg. proteinuria, signs of Fanconi’s Syndrome).
90 ml/ min) • pri pediatričnih bolnikih: nad ZMN (zgornjo mejo normale) ali pa očistek kreatinina pade pod SMN;
• The importance of measuring creatinine clearance • Brief overview of methods of measuring creatinine clearance • That rises in serum transaminases occur in patients treated with Exjade o The need for liver function tests prior to prescription, then at monthly intervals or more often if clinically indicated o Not to prescribe to patients with pre-existing severe hepatic disease o The need to interrupt treatment if persistent or progressive increase in liver enzymes were noted. • The need for annual auditory and ophthalmic testing • The need for a guidance table highlighting pre-treatment measurements of serum creatinine, creatinine clearance, proteinuria, hepatic enzymes, ferritin, such as:
• pomembnost merjenja očistka kreatinina; • kratek pregled metod merjenja očistka kreatinina; • dejstvo, da pri bolnikih, ki se zdravijo z zdravilom Exjade, prihaja do zvišanja vrednosti serumskih transaminaz, o potrebnost izvajanja testov jetrne funkcije preden se predpiše zdravilo, nato pa v mesečnih intervalih ali bolj pogosto, če je klinično indicirano, o opozorilo, da se bolnikom s predhodno hudo boleznijo jeter zdravila ne sme predpisati, o potrebnost prekinitve zdravljenja, če pride do persistentnega in progresivnega zvišanja vrednosti jetrnih encimov; • potrebnost enkrat letnega slušnega in okulističnega pregleda;
Before initiating treatment,
pred uvedbo zdravljenja
Serum creatinine at Day - X Serum creatinine at Day - Y
kreatinin v serumu na dan - X kreatinin v serumu na dan - Y
Value 1 Value 2
vrednost 1 vrednost 2
Significant changes found in auditory or ophthalmological testing Gallstones Unexpected ADRs according to the SPC.
X in Y sta dneva (ki ju je treba določiti) za izvedbo meritev pred zdravljenjem;
Patient inf ormation leaflet Information on the need for regular monitoring, and when it should be carried out, of serum creatinine, creatinine clearance, proteinuria, hepatic enzymes, ferritin
• izobraževalni program, ki bo zdravnike spodbujal k poročanju o resnih neželenih učinkih in določenih izbranih neželenih učinkih, navedenih spodaj: • vsi resni neželeni učinki, • persistentno in progresivno zvišanje vrednosti jetrnih encimov, • zvišanje vrednosti kretainina v serumu (> 33% nad izhodiščno vrednostjo) ali padec očistka kreatinina (< 90 ml/ min), • pomembne spremembe izvidov pri slušnem ali okulističnem pregledu, • žolčni kamni, • ne- pričakovani neželeni učinki zdravila glede na Povzetek glavnih značilnosti zdravila.
Inf ormation that renal biopsy may be considered if significant renal abnormalities occur.
Komplet podatkov o zdravilu za bolnika mora vsebovati naslednje informacije:
Patient b ooklet where the physician can record the results of the above along with the dose of Exjade
navodilo za uporabo zdravila za bolnika, o podatke o potrebnosti rednega spremljanja in časovni razpored preiskav kreatinina v o serumu, očistka kreatinina, proteinurije, jetrnih encimov in feritina, obvestilo o možnosti, da je v primeru pojava pomembnih ledvičnih nepravilnosti treba o razmisliti o ledvični biopsiji, bolnikovo knjižico, v katero lahko zdravnik beleži izvide navedenih preiskav skupaj z o odmerki zdravila Exjade, kartonček za načrtovane datume preiskav. o
It is available as round, white dispersible tablets that are mixed with a liquid to make up a suspension that the patient can drink.
Na voljo je v obliki okroglih, belih topljivih tablet, ki se s tekočino zmešajo v suspenzijo, ki jo bolnik lahko spije.
Each tablet contains 125 mg, 250 mg or 500 mg of deferasirox.
Posamezna tableta vsebuje 125 mg, 250 mg ali 500 mg deferasiroksa.
Exjade is used to treat a condition called chronic iron overload (an excess of iron in the body), which results from having repeated blood transfusions. • Exjade is used to reduce the amount of iron in the body of patients from six years of age who suffer from an inherited disease called beta thalassaemia major and who receive frequent blood transfusions to treat it.
Zdravilo Exjade se uporablja za zdravljenje kronične preobremenitve z železom (presežek železa v telesu), ki nastane zaradi ponavljajočih se transfuzij krvi. • Zdravilo Exjade se uporablja za zmanjšanje količine železa v telesu bolnikov od šestega leta starosti dalje, ki imajo dedno bolezen, imenovano beta talasemija major, za zdravljenje katere prejemajo pogoste transfuzije krvi.
Patients suffering from beta thalassaemia major are unable to make enough haemoglobin (the protein found in red blood cells that carries oxygen around the body), and they need regular blood transfusions.
Bolniki z beta talasemijo major ne morejo tvoriti dovolj hemoglobina (beljakovine v rdečih krvnih celicah, ki prenaša kisik po telesu), zato potrebujejo redne transfuzije krvi.