natgillin/translations-raw huggingface dataset:
As for the secondary endpoint of fatal and non-fatal cardiovascular events, there was no difference among the three groups in the overall population, although an increased incidence of non-fatal MI was seen for women and a decreased incidence of non-fatal MI was seen in males in the irbesartan group versus the placebo- based regimen.
V sekundarnem izidu fatalnih in nefatalnih srčno-žilnih dogodkov med tremi skupinami celotne populacije ni bilo razlik, čeprav je bilo v primerjavi s placebo skupino opaziti povečano pogostost nefatalnih miokardnih infarktov (MI) pri ženskah in zmanjšano pogostost nefatalnih MI pri moških v skupini, ki se je zdravila z irbesartanom.
As for the secondary endpoint of fatal and non-fatal cardiovascular events, there was no difference among the three groups in the overall population, although an increased incidence of non-fatal MI was seen for women and a decreased incidence of non-fatal MI was seen in males in the irbesartan group versus the placebo- based regimen.
V sekundarnem izidu fatalnih in nefatalnih srčnožilnih dogodkov med tremi skupinami celotne populacije ni bilo razlik, čeprav je bilo opaziti povečano pogostost nefatalnih MI (miokardni infarkt) pri ženskah in zmanjšano pogostost nefatalnih MI pri moških v skupini z irbesartanom, v primerjavi s placebo skupino.
As for the secondary endpoint of fatal and non-fatal cardiovascular events, there was no difference among the three groups in the overall population, although an increased incidence of non-fatal MI was seen for women and a decreased incidence of non-fatal MI was seen in males in the irbesartan group versus the placebobased regimen.
V sekundarnem izidu fatalnih in nefatalnih srčnožilnih dogodkov med tremi skupinami celotne populacije ni bilo razlik, čeprav je bilo opaziti povečano pogostost nefatalnih MI (miokardni infarkt) pri ženskah in zmanjšano pogostost nefatalnih MI pri moških v skupini z irbesartanom, v primerjavi s placebo skupino.
As GC- C receptor is known to be overexpressed at early ages, children younger than 2 years may be particularly sensitive to linaclotide effects.
Ker je znano, da so receptorji GC-C v mladih letih čezmerno izraženi, so lahko otroci do 2. leta starosti še posebej občutljivi na učinke linaklotida.
As Glubrava contains metformin hydrochloride, the treatment should be discontinued 48 hours before elective surgery with general anaesthesia and should not be usually resumed earlier than 48 hours afterwards.
Ker zdravilo Glubrava vsebuje metforminijev klorid, je potrebno zdravljenje prekiniti 48 ur pred načrtovanim operativnim posegom v splošni anesteziji, z njim pa običajno ne smemo nadaljevati prej kot v 48 urah po posegu.
As granisetron is metabolised by hepatic cytochrome P450 drug-metabolising enzymes (CYP1A1 and CYP3A4), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of granisetron.
Ker granisetron presnavljajo encimi citokroma P450 v jetrih, ki presnavljajo zdravila (CYP1A1 and CYP3A4), lahko spodbujevalci ali zaviralci teh encimov spremenijo očistek in s tem razpolovni čas granisetrona.
As Harvoni contains ledipasvir and sofosbuvir, any interactions that have been identified with these active substances individually may occur with Harvoni.
Zdravilo Harvonivsebuje ledipasvir in sofosbuvir, zato se pri uporabi zdravila Harvonilahko pojavijo katere koli interakcije, ki so jih opazili pri uporabi teh posameznih zdravilnih učinkovin.
As has been observed for DTPa and DTPa-containing combinations, an increase in local reactogenicity and fever was reported after booster vaccination with Infanrix Penta with respect to the primary course.
Kot pri DTPa cepivu in kombiniranih cepivih, ki vsebujejo DTPa, so poročali o povečanem pojavu lokalnih reakcij in zvišane telesne temperature po aplikaciji obnovitvenega odmerka cepiva Infanrix Penta v primerjavi z osnovnim cepljenjem.
As hepatotoxicity is more frequent in women with CD4 cell counts above 250 cells/mm3 with detectable HIV-1 RNA in plasma (50 or more copies/ml), these conditions should be taken in consideration on therapeutic decision (see section 4.4).
Ker je hepatotoksičnost pogostejša pri ženskah s številom celic CD4 nad 250 celic/mm3 in izmerljivo ravnijo HIV-1 RNA v plazmi (50 ali več kopij/ml), je potrebno ta stanja pri odločitvi o zdravljenju upoštevati (glejte poglavje 4.4).
As hepatotoxicity is more frequent in women with CD4 cell counts above 250 cells/mm3 with detectable HIV-1 RNA in plasma (50 or more copies/ml), these conditions should be taken in consideration on therapeutic decision (see section 4.4).
Ker je hepatotoksičnost pogostejša pri ženskah s številom celic CD4 nad 250 celic/mm3 in izmerljivo ravnijo HIV-1 RNA v plazmi (50 ali več kopij/ml), je treba ta stanja pri odločitvi o zdravljenju upoštevati (glejte poglavje 4.4).
As HIV can only reproduce itself within cells, Celsentri, taken in combination with other anti-HIV medicines, reduces the level of CCR5-tropic HIV in the blood of patients, and keeps it at a low level.
Ker se lahko virus HIV razmnožuje samo v celicah, zdravilo Celsentri, če ga jemljemo v kombinaciji z drugimi zdravili proti virusu HIV, zmanjša koncentracijo CCR5-tropnega HIV v bolnikovi krvi in jo vzdržuje na nizki ravni.
As HPA due to either PKU or BH4 deficiency is a chronic condition, once responsiveness is demonstrated, Kuvan is intended for long-term use.
HPA, do katere pride zaradi PKU ali zaradi pomanjkanja BH4, je kronično obolenje, zato je zdravilo Kuvan po tem, ko je bil odziv na zdravljenje dokazan, namenjeno dolgotrajni uporabi.
As human EP4 receptors are not activated by selexipag or its active metabolite, this effect is species-specific and, therefore, not relevant to humans.
Ker seleksipag ali njegov aktivni presnovek receptorjev EP4 pri človeku ne aktivira, je ta učinek specifičen za vrsto, zato za ljudi ni pomemben.
As human IgG1 is secreted into human milk, and the potential for harm to the infant is unknown, women should not breast-feed during Herceptin therapy and for 7 months after the last dose.
Ker se humani IgG izloča v materino mleko, potencialni škodljivi vpliv na otroka pa ni znan, naj ženske ne dojijo med zdravljenjem z zdravilom Herceptin in še 7 mesecev po zadnjem odmerku.
As human normal immunoglobulin has been used to treat these diseases for some time, and in accordance with current guidelines, four small studies were needed to establish the effectiveness and safety of Kiovig in patients.
Ker se humani normalni imunoglobulin že dalj časa uporablja za zdravljenje teh bolezni, so za potrditev učinkovitosti in varnosti zdravila Kiovig pri bolnikih v skladu z veljavnimi smernicami zadostovale le štiri manjše študije.
As human normal immunoglobulin has been used to treat these diseases for some time, and in accordance with current guidelines, Hizentra was investigated in one main study involving 51 PID patients who had already received human immunoglobulin treatment for at least six months.
Ker se humani polispecifični imunoglobulin za zdravljenje teh bolezni uporablja že kar nekaj časa, so v skladu s trenutnimi smernicami zdravilo Hizentra proučevali samo v eni glavni študiji, v kateri je sodelovalo 51 bolnikov s primarno imunsko pomanjkljivostjo, ki so se s humanim polispecifičnim imunoglobulinom predhodno že zdravili vsaj šest mesecev.
As ibrutinib solubility is pH dependent, there is a theoretical risk that medicinal products increasing stomach pH (e.g., proton pump inhibitors) may decrease ibrutinib exposure.
Topnost ibrutiniba je odvisna od pH, zato obstaja teoretična možnost, da lahko zdravila, ki zvišajo pH v želodcu (npr. zaviralci protonske črpalke), zmanjšajo izpostavljenost ibrutinibu.
As Icandra contains metformin, the treatment should be discontinued 48 hours before elective surgery with general anaesthesia and should not usually be resumed earlier than 48 hours afterwards.
Zdravilo Icandra vsebuje metformin, zato je treba zdravljenje z njim prekiniti 48 ur pred načrtovanim operacijskim posegom s splošno anestezijo, ponovno pa se ga sme uvesti šele 48 ur po posegu.
As in adult patients, children and adolescents experienced other psychiatric adverse events (e.g., depression, emotional lability, and somnolence).
Tako kot pri odraslih bolnikih so tudi pri otroci in mladostniki opazili druge psihiatrične neželene dogodke (npr. depresijo,
As in adult patients, children and adolescents experienced other psychiatric adverse reactions (e.g., depression, emotional lability, and somnolence).
Tako kot pri odraslih bolnikih so tudi pri otroci in mladostniki opazili druge psihiatrične neželene učinke (npr. depresijo, čustveno labilnost in zaspanost).
As in all postoperative patients, prophylactic measures need be considered to prevent VTE following surgery.
Kot pri vseh bolnicah po kirurškem posegu je treba pretehtati možnost uporabe preventivnih ukrepov, da se prepreči VTE po posegu.
As in kidney transplant recipients, there appears to be no meaningful difference in the pattern of suspected adverse drug reactions between once daily Envarsus and tacrolimus immediate-release capsules (Prograf).
Kot kaže pri prejemnikih presajene ledvice ni značilne razlike v vzorcu neželenih učinkov, ki so domnevno povezane z zdravilom Envarsus enkrat na dan in kapsulami takrolimusa s takojšnjim sproščanjem (zdravilo Prograf).
As in Study SC-I, there was no effect of immunogenicity on safety or efficacy.
Imunogenost ni vplivala na varnost ali učinkovitost zdravljenja, podobno kot v študiji SC-1.
As in the CLEOPATRA trial, a higher incidence of neutropenia and febrile neutropenia was observed among Asian patients compared with other patients in both neoadjuvant trials.
Tako kot pri preskušanju CLEOPATRA je bila v obeh preskušanjih neoadjuvantnega zdravljenja opažena večja incidenca nevtropenije in febrilne nevtropenije med azijskimi bolniki, v primerjavi z ostalimi bolniki.
As indicated in Section 2, a poor response to the vaccine, possibly without achieving protection against hepatitis B, is more common in older people, men rather than women, smokers, obese people, and people with long standing illnesses, or people on some type of drug treatments.
Kot je opisano v poglavju 2, se slab odziv na cepivo, lahko tudi brez dosežene zaščite proti hepatitisu B, pojavi bolj pogosto pri starejših osebah, pogosteje pri moških kot pri ženskah, kadilcih, osebah s prekomerno telesno maso, osebah z dolgotrajnimi boleznimi ali osebah, ki jemljejo določena zdravila.
As Infanrix hexa is not intended for use in adults, adequate human data on use during pregnancy or lactation and adequate animal reproduction studies are not available.
Ker cepivo Infanrix hexa ni namenjeno uporabi pri odraslih, ni podatkov o uporabi med nosečnostjo in dojenjem, prav tako ni na voljo ustreznih študij o vplivu na razmnoževanje pri živalih.
As initial combination with metformin: gastritis (common), arthralgia* (uncommon), myalgia (uncommon), and erectile dysfunction (uncommon).
Kot uvodna kombinacija z metforminom: gastritis (pogosto), artralgija* (občasno), mialgija (občasno) in erektilna disfunkcija (občasno).
As instructed by your doctor or pharmacist
Po navodilu zdravnika ali farmacevta.
As interactions with calcium and phosphate cannot be excluded, pausing supplementation with these substances and/or Vitamin D should be considered some days before starting with Xofigo treatment.
Ker ni možno izključiti medsebojnega delovanja s kalcijem in fosfatom, je treba razmisliti o prekinitvi uporabe prehranskih dopolnil s temi snovmi in/ali vitamina D nekaj dni pred uvedbo zdravljenja z zdravilom Xofigo.
as intra-gastric pH increases with
pH vrednosti želodčne vsebine
As INVEGA has not been studied in patients with creatinine clearance below 10 ml/min, use is not recommended in such patients.
Ker zdravila INVEGA niso proučevali pri bolnikih z očistkom kreatinina pod 10 ml/min, pri njih ne priporočamo njegove uporabe.
As iron is an essential building block for haemoglobin, the body can produce more haemoglobin and correct the anaemia once iron stores are replenished.
Ker je železo bistvena sestavina hemoglobina, lahko telo proizvaja več hemoglobina in odpravi anemijo, ko so zaloge železa obnovljene.
As it can not be excluded that Arava passes into semen, reliable contraception should be used during treatment with Arava.
Obstaja možnost, da se zdravilo Arava izloča v semensko tekočino, zato mora bolnik med zdravljenjem z zdravilom Arava uporabljati zanesljivo kontracepcijo.
As it can not be excluded that Leflunomide ratiopharm passes into semen, reliable contraception should be used during treatment with Leflunomide ratiopharm.
Obstaja možnost, da se zdravilo Leflunomid ratiopharm izloča v semensko tekočino, zato mora bolnik med zdravljenjem z zdravilom Leflunomid ratiopharm uporabljati zanesljivo kontracepcijo.
As it can not be excluded that Leflunomide Winthrop passes into semen, reliable contraception should be used during treatment with Leflunomide Winthrop.
Obstaja možnost, da se zdravilo Leflunomid Winthrop izloča v semensko tekočino, zato mora bolnik med zdravljenjem z zdravilom Leflunomid Winthrop uporablajti zanesljivo kontracepcijo.
As it can not be excluded that Leflunomide Winthrop passes into semen, reliable contraception should be used during treatment with Leflunomide Winthrop.
Obstaja možnost, da se zdravilo Leflunomid Winthrop izloča v semensko tekočino, zato mora bolnik med zdravljenjem z zdravilom Leflunomid Winthrop uporabljati zanesljivo kontracepcijo.
As it cannot be excluded that Leflunomide medac passes into semen, reliable contraception should be used during treatment with Leflunomide medac.
Obstaja možnost, da se zdravilo Leflunomid medac izloča v semensko tekočino, zato mora bolnik med zdravljenjem z zdravilom Leflunomid medac uporabljati zanesljivo kontracepcijo.
As it cannot be excluded that Leflunomide Teva passes into semen, reliable contraception should be used during treatment with Leflunomide Teva.
Obstaja možnost, da se zdravilo Leflunomid Teva izloča v semensko tekočino, zato mora bolnik med zdravljenjem z zdravilom Leflunomid Teva uporabljati zanesljivo kontracepcijo.
As it cannot be excluded that Repso passes into semen, reliable contraception should be used during treatment with Repso.
Obstaja možnost, da se zdravilo Repso izloča v semensko tekočino, zato mora bolnik med zdravljenjem z zdravilom Repso uporabljati zanesljivo kontracepcijo.
As it cannot be excluded that strong inhibition of hepatic P-gp may result in increased levels of trametinib, caution is advised when co- administering trametininb with medicinal products that are strong inhibitors of P-gp (e.g. verapamil, cyclosporine, ritonavir, quinidine, itraconazole).
Ni mogoče izključiti možnosti, da bi močno zaviranje prenašalca P-gp v jetrih povzročilo zvišanje koncentracije trametiniba, zato je priporočena previdnost pri sočasnem odmerjanju trametiniba in zdravil, ki so močni zaviralci P-gp (na primer verapamila, ciklosporina, ritonavirja, kinidina, itrakonazola).
As it cannot be excluded that the change in Cmax is clinically significant, Temomedac should be administered without food.
Ker ni mogoče izključiti možnosti, da bi bila sprememba Cmax lahko klinično pomembna, naj bolniki jemljejo zdravilo Temomedac brez hrane.
As it cannot be excluded that the change in Cmax is clinically significant, Temozolomide Teva should be administered without food.
Ker ni mogoče izključiti, da je sprememba vrednosti Cmax klinično pomembna, je treba zdravilo Temozolomide Teva jemati brez hrane.
As it is not known whether orlistat is secreted into human milk, alli is contraindicated during breast- feeding (see section 4.3).
Ker ni znano, ali orlistat pri ljudeh prehaja v mleko, je zdravilo alli med dojenjem kontraindicirano (glejte poglavje 4.3).
As it is not possible to achieve this fosamprenavir dose using the tablet formulation, these patients should be treated with fosamprenavir oral suspension.
Tega odmerka fosamprenavirja ni mogoče doseči s tabletami, zato je treba takšne bolnike zdraviti s peroralno suspenzijo fosamprenavirja.
As it is preservative-free, the contents of the whole ampoule should be used immediately after opening and any unused solution should be discarded.
Ker ne vsebuje konzervansov, je treba celotno vsebino ampule uporabiti takoj po odprtju, neporabljeno raztopino pa je treba zavreči.
As Janumet contains metformin hydrochloride, the treatment should be discontinued 48 hours before elective surgery with general, spinal or epidural anaesthesia.
Zdravilo Janumet vsebuje metforminijev klorid, zato je treba zdravljenje prekiniti 48 ur pred elektivno operacijo pod splošno, spinalno ali epiduralno anestezijo.
As Jentadueto contains metformin hydrochloride the treatment must be discontinued 48 hours before elective surgery with general, spinal or epidural anaesthesia.
Ker vsebuje zdravilo Jentadueto metforminijev klorid, je treba zdravljenje z njim prekiniti 48 ur pred kirurškim posegom v splošni, spinalni ali epiduralni anesteziji.
As Jentadueto contains metformin, a patient with previously well controlled type 2 diabetes on Jentadueto who develops laboratory abnormalities or clinical illness (especially vague and poorly defined illness) should be evaluated promptly for evidence of ketoacidosis or lactic acidosis.
Ker vsebuje zdravilo Jentadueto metformin, je treba stanje bolnika z dotlej dobro urejeno sladkorno boleznijo tipa 2 s tem zdravilom, nemudoma oceniti, kadar se pri njem pojavijo laboratorijske nepravilnosti ali klinična bolezen (zlasti nedoločena ali slabo opredeljena), da bi odkrili znake ketoacidoze ali laktacidoze.
As known from substances acting on the Renin-Angiotensin-Aldosterone System (RAAS), a slight decrease in red blood cell count may occur.
Kot pri uporabi drugih zdravil, ki delujejo na sistem renin-angiotenzin-aldosteron (RAAS, renin- angiotensin-aldosterone-system), se lahko število rdečih krvnih celic blago zniža.
As Kyprolis is given in combination with lenalidomide, you must follow the Pregnancy Prevention Programme (see package leaflet for lenalidomide for information on pregnancy prevention and discuss with your doctor, pharmacist or nurse).
Zdravilo Kyprolis se uporablja v kombinaciji z lenalidomidom, zato morate ravnati v skladu s programom za preprečevanje nosečnosti (glejte navodilo za uporabo lenalidomida za informacije o preprečevanju nosečnosti ter se pogovorite z zdravnikom, farmacevtom ali z medicinsko sestro).
As lamivudine is a nucleoside analogue, this risk cannot be excluded.
Ker je lamivudin nukleozidni analog, tega tveganja ni mogoče izključiti.
As large numbers of granulocytes gather at the site of an infection, the radioactivity will accumulate where there is an infection, and it can be detected using special scanning techniques, such as scintigraphy or SPECT (single photon emission computed tomography).
Ker se na mestu okužbe zbere veliko število granulocitov, se radioaktivnost nakopiči na mestu, kjer je okužba, in jo je mogoče zaznati z uporabo
As lepirudin is almost exclusively excreted and metabolised renally (see also section 5.2), the patient’s renal function should be considered prior to administration.
Ker se lepirudin izloča in presnavlja skoraj izključno preko ledvic (glejte tudi poglavje 5.2), je treba pred dajanjem upoštevati bolnikovo ledvično funkcijo.
As little as one capsule taken by a pregnant woman can cause a baby to have serious birth defects.
Že samo ena kapsula, ki jo vzame nosečnica, lahko povzroči resne prirojene okvare.
As maropitant is accumulated in the body during a 14 day treatment period due to metabolic saturation, careful monitoring of liver function and any adverse events should be implemented during long term treatment.
Med dolgotrajnim zdravljenjem je treba skrbno spremljati delovanje jeter in in druge neželene učinke, ker se maropitant zaradi saturacije presnove med 14 dnevnim zdravljenjem, kopiči v telesu.
As maropitant is accumulated in the body during a 14 day treatment period due to metabolic saturation, careful monitoring of liver function in addition to any adverse events should be implemented during long term treatment.
Med dolgotrajnim zdravljenjem je treba skrbno spremljati delovanje jeter in in druge neželene učinke, ker se maropitant zaradi saturacije presnove med 14 dnevnim zdravljenjem, kopiči v telesu.
As maropitant is accumulated in the body during a 14 day treatment period due to metabolic saturation, careful monitoring of liver function should be implemented during long term treatment.
Med dolgotrajnim zdravljenjem je treba skrbno spremljati delovanje jeter in in druge neželene učinke, ker se maropitant zaradi saturacije presnove med 14 dnevnim zdravljenjem, kopiči v telesu.
As medicines of the same class as Anoro may have an effect on the heart and blood vessels in the brain, the company will continue to closely monitor the medicine’s effects on the heart and brain and will carry out further long-term studies in patients to identify any potential risks.
Ker zdravila istega razreda kot zdravilo Anoro lahko vplivajo na srce in krvne žile v možganih, bo družba, ki izdeluje zdravilo Anoro, še naprej pozorno spremljala učinke zdravila na srce in možgane ter izvedla nadaljnje dolgoročne študije pri bolnikih, da bi opredelila morebitna tveganja.
As medicines of the same class as Laventair may have an effect on the heart and blood vessels in the brain, the company will continue to closely monitor the medicine’s effects on the heart and brain and will carry out a further long-term study in patients to identify any potential risks.
Ker zdravila, ki sodijo v isti razred kot zdravilo Laventair, lahko vplivajo na srce in krvne žile v možganih, bo družba pozorno spremljala učinke zdravila na srce in možgane ter izvedla dodatno študijo pri bolnikih za ugotovitev morebitnih tveganj.
As mentioned in 'Warnings and precautions', above, the most important side effects of Viramune are severe and life threatening skin reactions and serious liver damage.
Kot je navedeno v ”Opozorila in previdnostni ukrepi”, so njeni najpomembnejši neželeni učinki hude, tudi življenjsko nevarne kožne reakcije in resne okvare jeter.
As mentioned in ‘Warnings and precautions', above, the most important side effects of Viramune are severe and life threatening skin reactions and serious liver damage.
Kot je navedeno v ”Opozorila in previdnostni ukrepi”, so najpomembnejši neželeni učinki zdravila Viramune hude, tudi življenjsko nevarne kožne reakcije in resne okvare jeter.
As mentioned in ‘Warnings and precautions', above, the most important side effects of Viramune are severe and life threatening skin reactions and serious liver damage.
Kot je navedeno v ”Opozorila in previdnostni ukrepi”, so njihovi najpomembnejši neželeni učinki hude, tudi življenjsko nevarne kožne reakcije in resne okvare jeter.
As mepolizumab is a monoclonal antibody, no genotoxicity or carcinogenicity studies have been conducted.
Ker je mepolizumab monoklonsko protitelo, študij genotoksičnosti in kancerogenosti niso izvedli.
As metabolism and excretion of doxorubicin occurs primarily by the hepatobiliary route, evaluation of hepatobiliary function should be performed before and during therapy with Myocet.
Presnova in izločanje doksorubicina potekata predvsem po hepatobiliarni poti, zato morate pred zdravljenjem z zdravilom Myocet in med njim oceniti hepatobiliarno delovanje.
As metformin hydrochloride is excreted by the kidney, serum creatinine levels should be determined before initiating treatment and regularly thereafter:
Ker se metforminijev klorid izloča skozi ledvice, je treba pred začetkom zdravljenja in redno med zdravljenjem določati raven kreatinina v serumu:
As metformin is excreted by the kidney, and metformin accumulation may precipitate lactic acidosis, eGFR or creatinine clearance should be determined before initiating treatment and regularly thereafter:
Ker se metformin izloča preko ledvic, in kopičenje metformina lahko pospeši pojav laktacidoze, je treba ocenjeno glomerulno filtracijo ali očistek kreatinina določati pred začetkom zdravljenja in redno med zdravljenjem, in sicer:
As metformin is excreted by the kidney, serum creatinine concentrations should be determined regularly:
Metformin se izloča skozi ledvice, zato je treba koncentracijo kreatinina v serumu redno kontrolirati: