natgillin/translations-raw huggingface dataset:
Rifabutin, 150 mg QD
odmerka 150 mg 3-krat na teden.
Rifabutin, 150 mg QD
Rifabutin, 150 mg
Rifabutin, 150 mg QD
trazodon:
Rifabutin, a medicine to treat some bacterial infections.
Rifabutin, zdravilo, ki se uporablja za zdravljenje nekaterih bakterijskih okužb.
rifabutin, a medicine used to treat bacterial infections including tuberculosis
rifabutin, zdravilo, ki se uporablja za zdravljenje bakterijskih okužb, vključno s tuberkulozo
Rifabutin, erythromycin or clarithromycin (for bacterial infections)
rifabutin, eritromicin ali klaritromicin (za bakterijske okužbe),
rifabutin, rifampicin and rifapentine (used to treat some bacterial infections such as tuberculosis)
rifabutin, rifampicin in rifapentin (uporablja se za zdravljenje nekaterih bakterijskih okužb, kot je tuberkuloza)
rifabutin, rifampicin or rifapentine
rifabutin, rifampicin ali rifapentin
Rifabutin, rifampicin, rifapentine
rifabutin, rifampicin, rifapentin
rifabutin, rifampicin, rifapentine (antibiotics);
rifabutin, rifampicin, rifapentin (antibiotiki);
rifabutin, rifampicin: medicines to treat tuberculosis or certain other infections.
rifabutin, rifampicin: zdravili za zdravljenje tuberkuloze ali nekaterih drugih okužb
rifabutin, used to treat bacterial infections including tuberculosis
rifabutin, uporablja se za zdravljenje bakterijskih okužb, vključno s tuberkulozo
Rifabutin/efavirenz (300 mg once daily/600 mg once daily)
(300 mg enkrat na dan/600 mg
Rifabutin/Tenofovir disoproxil fumarate
rifabutin/dizoproksiltenofovirijev fumarat
rifabutin;
rifabutin,
Rifampicin
kolhicin - enkraten
Rifampicin
očasno uporabo z
Rifampicin (600 mg once daily)/
rifampicin (600 mg enkrat dnevno)/
Rifampicin (600 mg once daily)/ ledipasvir (90 mg single dose)d
Rifampicin (600 mg enkrat na dan)/ ledipasvir (90 mg enkratni odmerek)d
Rifampicin (600 mg once daily)/ Rilpivirine1
rifampicin(600 mg enkrat dnevno)/ rilpivirin1
rifampicin (a medicine to treat tuberculosis and other infections).
rifampicin (zdravilo za zdravljenje tuberkuloze in drugih okužb).
rifampicin (an antibiotic used to prevent and treat infections such as tuberculosis)
rifampicin (antibiotik, ki se uporablja za preprečevanje in zdravljenje okužb, kot je tuberkuloza),
Rifampicin (an antibiotic used to treat tuberculosis)
rifampicin (antibiotik za zdravljenje tuberkuloze),
rifampicin (an antibiotic used to treat tuberculosis)
rifampicin (antibiotik za zdravljenje tuberkuloze).
rifampicin (an antibiotic used to treat tuberculosis)
rifampicin (antibiotik, s katerim zdravimo tuberkulozo),
Rifampicin (for tuberculosis).
rifampicin (za tuberkulozo)
rifampicin (medicine to treat tuberculosis)
rifampicin (zdravilo za zdravljenje tuberkuloze)
rifampicin (medicine to treat tuberculosis)
rifampicin (zdravilo za zdravljenje tuberkuloze),
rifampicin (raltegravir 400 mg Single Dose)
rifampicin (raltegravir 400 mg enkratni odmerek)
rifampicin (risk of severe hepatocellular toxicity) (see sections 4.4, 4.5, and 4.8) quetiapine (risk of coma, see section 4.5).
rifampicin (tveganje za hudo hepatocelularno toksičnost) (glejte poglavja 4.4, 4.5 in 4.8), kvetiapin (tveganje za nastop kome, glejte poglavje 4.5).
rifampicin (to treat bacterial infections)
rifampicin (za bakterijske okužbe),
rifampicin (to treat infections, tuberculosis) glucagon (to treat severe low blood sugar levels)
rifampicin (za zdravljenje okužb, tuberkuloze) glukagon (za zdravljenje zelo nizkih ravni sladkorja v krvi)
rifampicin (to treat tuberculosis and other infections )
rifampicin (za zdravljenje tuberkuloze in drugih okužb)
rifampicin (used to prevent and treat tuberculosis and other infections)
rifampicin (uporablja se za preprečevanje in zdravljenje tuberkuloze in drugih okužb)
Rifampicin (used to treat bacterial infections)
rifampicin (uporablja se za zdravljenje bakterijskih okužb)
rifampicin (used to treat tuberculosis and other infections)
rifampicin (uporablja se za zdravljenje tuberkuloze in drugih okužb)
rifampicin (used to treat tuberculosis and other infections) cimetidine (used to reduce stomach acid).
rifampicin (uporabljamo ga za zdravljenje tuberkuloze in drugih okužb). cimetidin (uporabljamo ga za zmanjševanje kislosti želodčnega soka).
rifampicin (used to treat tuberculosis and other infections) fluconazole (used to treat fungal infections).
rifampicin (uporabljamo ga za zdravljenje tuberkuloze in drugih okužb). flukonazol (uporabljamo ga za zdravljenje glivičnih okužb).
Rifampicin (used to treat tuberculosis)
rifampicin (uporablja se za zdravljenje tuberkuloze)
rifampicin (used to treat tuberculosis)
rifampicin (uporabljamo ga za zdravljenje tuberkuloze)
rifampicin (used to treat tuberculosis)
rifampicin (uporabljamo ga za zdravljenje tuberkuloze).
rifampicin (used to treat tuberculosis)
rifampicin (za zdravljenje tuberkuloze),
rifampicin (used to treat tuberculosis) xanthines (used to treat asthma)
rifampicin (uporablja se za zdravljenje tuberkuloze),
rifampicin (used to treat tuberculosis),
rifampicin (za zdravljenje tuberkuloze),
rifampicin (used to treat tuberculosis);
rifampicin (uporablja se za zdravljenje tuberkuloze);
rifampicin - an antibiotic used to treat infections
rifampicin – antibiotik, ki se uporablja za zdravljenje okužb
rifampicin - for preventing or treating tuberculosis
rifampicin - za preprečevanje ali zdravljenje tuberkuloze,
rifampicin - this is a treatment for tuberculosis famotidine, omeprazole - these are medicines that block stomach acids
rifampicin - zdravilo za zdravljenje tuberkuloze,
rifampicin /raltegravir (raltegravir 400 mg Single Dose)
rifampicin/raltegravir (enkraten odmerek 400 mg raltegravirja)
Rifampicin 600 mg once daily (daclatasvir 60 mg single dose)
Rifampicin 600 mg enkrat na
Rifampicin 600 mg QD
Rifampicin
Rifampicin 600 mg qd (saquinavir/ritonavir 1000/100 mg bid)
rifabutin 150 mg vsak tretji dan (sakvinavir/ritonavir 1000/100 mg dvakrat na dan) pri zdravih prostovoljcih
Rifampicin 600 mg qd (saquinavir/ritonavir 1000/100 mg bid)
rifampicin 600 mg enkrat
Rifampicin 600 mg qd x 7 days (Nelfinavir 750 mg q8h x 5-6 days)
efavirenz 600 mg enkrat na dan (nelfinavir 750 mg trikrat na dan)
Rifampicin Although rifampicin may induce metabolism of ritonavir, limited data indicate that when high doses of ritonavir (600 mg twice daily) is co-administered with rifampicin, the additional inducing effect of rifampicin (next to that of ritonavir itself) is small and may have no clinical relevant effect on ritonavir levels in high-dose ritonavir therapy.
Rifampicin Rifampicin lahko inducira presnovo ritonavirja, vendar omejeni podatki kažejo, da je ob sočasni uporabi visokih odmerkov ritonavirja (600 mg dvakrat dnevno) in rifampicina dodatni inducirajoči vpliv rifampicina (poleg ritonavirja samega) majhen in v primeru visokoodmerne terapije z ritonavirjem nima klinično pomembnega vpliva na koncentracijo ritonavirja.
Rifampicin and other known potent CYP and transporter inducers such as carbamazepine, phenobarbital, phenytoin and St John’s Wort should be used with caution during the treatment with teriflunomide.
Rifampicin in druge znane močne induktorje CYP in transporterjev, kot so karbamazepin, fenobarbital, fenitoin in šentjanževka, je treba med zdravljenjem s teriflunomidom uporabljati previdno.
Rifampicin and rifabutin commonly used to treat tuberculosis.
Rifampicin in rifabutin, ki se pogosto uporabljata za zdravljenje tuberkuloze.
rifampicin and rifapentine (used to treat some bacterial infections such as tuberculosis)
rifampicin in rifapentin (uporablja se za zdravljenje nekaterih bakterijskih okužb, kot je tuberkuloza)
Rifampicin and saquinavir (used for tuberculosis and HIV, respectively) as serious liver damage can occur when taken with Norvir.
Rifampicin in sakvinavir (prvi je zdravilo proti tuberkulozi, drugi zdravilo proti HIV), ker lahko sočasna uporaba z zdravilom Norvir povzroči resno okvaro jeter
Rifampicin and saquinavir (used for tuberculosis and HIV, respectively) as serious liver damage can occur when taken with Norvir.
Rifampicin in sakvinavir (prvi je zdravilo proti tuberkulozi, drugi zdravilo proti HIV), ker lahko sočasna uporaba z zdravilom Norvir povzroči resno okvaro jeter.
rifampicin AUC ↔ rifampicin Cmin NA rifampicin Cmax ↔
rifampicin AUC ↔ rifampicin Cmin NS rifampicin Cmax ↔
Rifampicin AUC  1.11 (0.96-1.28)
AUC rifampicina  1,11 (0,96-1,28)
Rifampicin Cmax  1.06 (0.91-1.22)
Cmax rifampicina  1,06 (0,91-1,22)
Rifampicin Cmin ND
Cmin rifampicina ND
rifampicin Cmin not studied
posakonazol
Rifampicin concentrations not measured
Koncentracija rifampicina ni bila merjena.
Rifampicin concentrations not measured
Varnosti kombinacije niso
Rifampicin in combination with Kaletra causes large decreases in lopinavir concentrations which may in turn significantly decrease the lopinavir therapeutic effect.
Rifampicina v kombinaciji z zdravilom Kaletra povzroči veliko znižanje koncentracij lopinavirja s posledičnim pomembnim zmanjšanjem terapevtskega učinka lopinavirja.
Rifampicin increased the clearance of sirolimus by approximately 5.5-fold and decreased AUC and Cmax by approximately 82% and 71%, respectively.
Rifampicin poveča izločanje sirolimusa za približno 5,5-krat ter zmanjša AUC za približno 82 % in Cmax za približno 71 %.
Rifampicin is contraindicated in combination with boosted PIs.
Sočasna uporaba rifampicina in okrepljenih PI je kontraindicirana.
Rifampicin is contraindicated in combination with Invirase/ritonavir (see section 4.3).
Rifampicin je v kombinaciji z
Rifampicin reduces plasma levels of ISENTRESS.
Rifampicin zmanjša plazemske koncentracije zdravila ISENTRESS.
rifampicin – for preventing or treating tuberculosis
rifampicin - za preprečevanje ali zdravljenje tuberkuloze,
Rifampicin – used for bacterial infections
rifampicin – uporablja se pri bakterijskih okužbah
rifampicin – used for bacterial infections,
rifampicin – uporablja se za zdravljenje bakterijskih okužb,
Rifampicin, a strong inducer of CYP3A4/5, administered at a dose of 600 mg once daily for 9 days, reduced the mean AUC by 79% and Cmax by 71% of a single 5 mg dose of axitinib in healthy volunteers.
Pri zdravih prostovoljcih je rifampicin, močan induktor CYP3A4/5 (v odmerku 600 mg enkrat na dan v obdobju 9 dni) po enkratnem 5 mg odmerku aksitiniba povprečno vrednost površine pod krivuljo (AUC) zmanjšal za 79 %, Cmax pa za 71 %.
rifampicin, an antibiotic used to treat bacterial infections
rifampicin, antibiotik, ki se uporablja za zdravljenje bakterijskih okužb
rifampicin, an antibiotic used to treat infections such as tuberculosis
rifampicin, antibiotik, ki se uporablja za zdravljenje okužb, kot je tuberkuloza
rifampicin, clarithromycin, telithromycin (antibiotics used to treat infections),
rifampicin, klaritromicin, telitromicin (antibiotiki za zdravljenje okužb)
rifampicin, clarithromycin, telithromycin (antibiotics used to treat infections),
rifampicin, klaritromicin, telitromicin (antibiotiki za zdravljenje okužb),
rifampicin, clarithromycin, telithromycin (antibiotics used to treat infections),
rifampicin, klaritromicin, telitromicin (antibiotiki, ki se uporabljajo za zdravljenje okužb),
rifampicin, erythromycin , clarithromycin or itraconazole. other treatments for erectile dysfunction.
rifampicin, eritromicin, klaritromicin ali itrakonazol. druga zdravila za zdravljenje erektilne disfunkcije.
rifampicin, erythromycin, clarithromycin or itraconazole. other treatments for erectile dysfunction.
rifampicin, eritromicin, klaritromicin ali itrakonazol. druga zdravila za zdravljenje erektilne disfunkcije.
rifampicin, inhibition of
rifampicinom, zaviranje
rifampicin, rifabutin (antibiotics);
rifampicin, rifabutin (antibiotični zdravili);
Rifampicin, rifabutin or isoniazid (used to treat tuberculosis);
rifampicin, rifabutin ali izoniazid (uporabljajo se za zdravljenje tuberkuloze);
rifampicin, rifabutin or rifapentine, antibiotics used to treat tuberculosis
rifampicin, rifabutin ali rifapentin, antibiotiki za zdravljenje tuberkuloze.
rifampicin, rifabutin, used for tuberculosis,
rifampicin, rifabutin, ki se uporabljata za zdravljenje tuberkuloze,
rifampicin, rifapentine (antibiotics);
rifampicin in rifapentin (antibiotika);
rifampicin, rifapentine (antibiotics);
rifampicin in rifapentin (antibiotični zdravili);
rifampicin, rifapentine (medicines to treat some bacterial infections such as tuberculosis)
rifampicin, rifapentin (zdravila za zdravljenje bakterijskih okužb kot je tuberkuloza),
rifampicin, used to prevent and treat tuberculosis and other infections
rifampici; uporablja se za preprečevanje in zdravljenje tuberkuloze in drugih okužb
rifampicin, used to prevent and treat tuberculosis and other infections
rifampicin; uporablja se za preprečevanje in zdravljenje tuberkuloze in drugih okužb
rifampicin, used to treat tuberculosis or meningitis, herbal preparation containing hypericum perforatum (St John’s wort) used to treat minor to moderate depression.
rifampicin, ki se uporablja za zdravljenje tuberkuloze in meningitisa, zeliščni pripravek, ki vsebuje hypericum perforatum (šentjanževko), ki se uporablja za zdravljenje blage do zmerne depresije.
rifampicin, used to treat tuberculosis.
rifampicin, ki se uporablja za zdravljenje tuberkuloze
rifampicin.
rifampicinom.
Rifampicin/Dolutegravir
(kotrimoksazol)/lamivudin
Rifampicin/efavirenz (600 mg once daily/600 mg once daily)
(600 mg enkrat na dan/600 mg
Rifampicin/Tenofovir disoproxil fumarate
metadon/dizoproksiltenofovirijev fumarat
Rifampicin: co-administration in 9 healthy subjects for 7 days of bosentan 125 mg twice daily with rifampicin, a potent inducer of CYP2C9 and CYP3A4, decreased the plasma concentrations of bosentan by 58%, and this decrease could achieve almost 90% in an individual case.
Rifampicin: 7-dnevno sočasno dajanje bosentana 125 mg dvakrat na dan in rifampicina, močnega induktorja CYP2C9 in CYP3A4, 9 zdravim osebam je zmanjšalo plazemske koncentracije bosentana za 58 %, v enem primeru je to zmanjšanje doseglo 90 %.
Rifampicin: Pre-dosing of the probe inducer rifampicin at a dose of 600 mg once daily for 7 days decreased total dabigatran peak and total exposure by 65.5 and 67 %, respectively.
Rifampicin: Pri predhodnem dajanju preizkušanega induktorja rifampicina v odmerkih po 600 mg enkrat na dan, 7 dni, sta se skupna najvišja koncentracija dabigatrana in izpostavljenost zmanjšala za 65,5 oziroma 67 %.
rifampicin;
rifampicin,
Rifampicinf (600 mg single dose)
Rifampicinf (600 mg enkratni odmerek)
rifampin (used to treat tuberculosis and some other infections)
rifampin (uporablja se za zdravljenje tuberkuloze in nekaterih drugih okužb),
rifampin – to treat tuberculosis warfarin – to prevent and treat blood clots forming in the legs, lungs, brain and heart.
rifampicin – za zdravljenje tuberkuloze varfarin - za preprečevanje in zdravljenje krvnih strdkov v nogah, pljučih, možganih in srcu.
Rifampin, an inhibitor of OATPs and an inducer of CYP2C9, decreased lesinurad exposure and slightly reduced the amount of lesinurad excreted unchanged in urine with no clinically relevant effect.
Rifampicin, ki je zaviralec proteinskega prenašalca organskih anionov (OATP – organic anion transporting protein) in induktor CYP2C9, je zmanjšal izpostavljenost lesinuradu in rahlo zmanjšal količino lesinurada, ki se je nespremenjen izločil v urinu, brez klinično pomembnega učinka.
Rifamycin antibacterials (rifampicin, rifabutin), certain anticonvulsants (phenytoin, carbamazepine, phenobarbital, primidone), and efavirenz.
Rifamicinski antibiotiki (rifampicin, rifabutin), določeni antikonvulzivi (fenitoin, karbamazepin, fenobarbital, primidon) in efavirenz
Rifamycin antibacterials (rifampicin, rifabutin), certain anticonvulsants (phenytoin, carbamazepine, phenobarbital, primidone), efavirenz and cimetidine
Rifamicinski antibiotiki (rifampicin, rifabutin), določeni antikonvulzivi (fenitoin, karbamazepin, fenobarbital, primidon), efavirenz in cimetidin
Rifapentine
vorikonazol
rifapentine (antibiotic used to treat infections, including tuberculosis);
rifampicin (antibiotik, ki se uporablja za zdravljenje okužb, vključno s tuberkulozo),
rifapentine (antibiotic used to treat infections, including tuberculosis);
rifampicin (antibiotik, ki se uporablja za zdravljenje okužb, vključno s tuberkulozo);
Rifapentine and rifampicin
Rifapentin in rifampicin
rifapentine as
vorikonazolom ni
Rifapentine2
rifapentin2
rigid muscles,
otrdele mišice,
Rigid needle guard
trden ščitnik igle
rigid posture
okorela drža
Rigors
Okorelost
Rigors
Otrplost
Rigors
Rigor (okorelost)
rigors
tresavica
rigors (cold shivering sensation) or chills
okorelost (občutek mrzlice) ali mrzlica
Rigors, asthenia, pain, infusion site inflammation, injection site oedema, injection site pain, injection site pruritus, injection site swelling, migration of implant
okorelost, astenija, bolečina, vnetje na mestu infundiranja, edem na mestu injiciranja, bolečina na mestu injiciranja, pruritus na mestu injiciranja, oteklina na mestu injiciranja, premik vsadka
rigors, pyrexia, pain and discomfort, fatigue
mrzlica, zvišana telesna temperatura, bolečina in neprijeten občutek, utrujenost
Rilonacept Regeneron 80 mg/ml powder and solvent for solution for injection rilonacept
Rilonacept Regeneron 80 mg/ml prašek in vehikel za raztopino za injiciranje rilonacept
Rilonacept Regeneron 80 mg/ml powder and solvent for solution for injection.
Rilonacept Regeneron 80 mg/ml prašek in vehikel za raztopino za injiciranje.
Rilonacept Regeneron 80 mg/ml powder for solution for injection rilonacept
Rilonacept Regeneron 80 mg/ml prašek za raztopino za injiciranje rilonacept
Rilonacept Regeneron has not been studied in patients with hepatic impairment.
Pri bolnikih z okvarami jeter zdravila Rilonacept Regeneron niso proučevali.
Rilonacept Regeneron is indicated for the treatment of Cryopyrin-Associated Periodic Syndromes (CAPS) with severe symptoms, including Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS), in adults and children aged 12 years and older.
Zdravilo Rilonacept Regeneron je indicirano za zdravljenje s kriopirinom povezanih periodičnih sindromov (CAPS) s težkimi simptomi, vključno s familiarnim avtoinflamatornim sindromom zaradi mraza (FCAS) in Muckle-Wellsovim sindromom (MWS), pri odraslih in otrocih, starih 12 let ali več.
Rilonacept Regeneron is injected into the tissue directly below the layers of skin.
Zdravilo Rilonacept Regeneron se injicira v tkivo neposredno pod plastmi kože.
Rilonacept Regeneron is provided as a powder for solution for injection in a glass vial.
Zdravilo Rilonacept Regeneron je na voljo kot prašek za raztopino za injiciranje v stekleni viali.
Rilonacept Regeneron should not be given more often than once weekly.
Zdravilo Rilonacept Regeneron naj se ne daje pogosteje kot enkrat na teden.
Rilonacept Regeneron should not be given more often than once weekly.
Zdravilo Rilonacept Regeneron naj se ne daje pogosteje kot enkrat tedensko.
Rilpivirine
amim)
Rilpivirine
dnevno)/rilpivirin
Rilpivirine
Interakcija
Rilpivirine (25 mg once daily)
dnevno)/rilpivirin (25 mg enkrat dnevno)
Rilpivirine + Emtricitabine/ Tenofovir disoproxil fumarate n = 550
Rilpivirin + emtricitabin/ dizoproksiltenofov irijev fumarat n = 550
Rilpivirine + Emtricitabine/ Tenofovir disoproxil fumarate n = 550
Rilpivirin + emtricitabin/ dizoproksiltenofovi rijev fumarat n = 550
Rilpivirine + Emtricitabine/Tenofovir disoproxil fumarate n = 550
Rilpivirin + emtricitabin/dizoproksiltenofovi rijev fumarat n = 550
Rilpivirine activity is mediated by non-competitive inhibition of HIV-1 RT.
Aktivnost rilpivirina poteka s pomočjo nekompetitivnega zaviranja HIV-1 RT.
Rilpivirine at a dose of 25 mg once daily is not likely to have a clinically relevant effect on the exposure of medicinal products metabolised by CYP enzymes.
Ni verjetno, da bi rilpivirin v odmerku 25 mg enkrat na dan klinično pomembno vplival na izpostavljenost učinkovinam, ki jih presnavljajo encimi CYP.
rilpivirine AUC ↑ 13% rilpivirine Cmin NA rilpivirine Cmax ↑ 21%
rilpivirin AUC ↑ 13% rilpivirin Cmin NS rilpivirin Cmax ↑ 21
rilpivirine AUC ↓ 76% rilpivirine Cmin NA rilpivirine Cmax ↓ 85%
rilpivirin AUC ↓ 76% rilpivirin Cmin NS rilpivirin Cmax ↓ 85
rilpivirine AUC ↓ 9% rilpivirine Cmin NA rilpivirine Cmax ↔
rilpivirin AUC ↓ 9% rilpivirin Cmin NS rilpivirin Cmax ↔
Rilpivirine does not inhibit the human cellular DNA polymerases α, β and mitochondrial DNA polymerase γ.
Rilpivirin ne zavira humanih celičnih DNA-polimeraz α, β in mitohondrijske DNA-polimeraze γ.
Rilpivirine exposure is substantially increased (3-fold) when rilpivirine is given in combination with dasabuvir with ombitasvir/paritaprevir/ritonavir, with a consequent potential for QT-prolongation.
Če je rilpivirin uporabljen v kombinaciji z dasabuvirjem z ombitasvirjem/paritaprevirjem/ritonavirjem, se izpostavljenost rilpivirinu bistveno zveča (3-krat) in posledično se lahko pojavi podaljšanje QT.
Rilpivirine has not been studied in patients with severe hepatic impairment (Child-Pugh Class C).
Rilpivirina niso preučevali pri bolnikih s hudo jetrno okvaro (stopnje C po Child-Pughu).
Rilpivirine has not been studied in patients with severe hepatic impairment (CPT Score C) (see section 4.2).
Rilpivirina niso preučevali pri bolnikih s hudo jetrno okvaro (stopnje C po CPT) (glejte poglavje 4.2).
Rilpivirine inhibits P-glycoprotein in vitro (IC50 is 9.2 μM).
Rilpivirin in vitro zavira P-glikoprotein (IC50 je 9,2 μM).
Rilpivirine is an in vitro inhibitor of the transporter MATE-2K with an IC50 of < 2.7 nM.
Rilpivirin je in vitro zaviralec prenašalca MATE-2K z IC50 < 2,7 nM.
Rilpivirine is primarily metabolised by cytochrome P450 (CYP)3A. Medicinal products that induce or inhibit CYP3A may thus affect the clearance of rilpivirine (see section 5.2).
Presnova rilpivirina poteka večinoma preko citokroma P450 (CYP)3A. Zdravila, ki inducirajo ali zavirajo encim CYP3A, lahko vplivajo na izločanje rilpivirina (glejte poglavje 5.2).
Rilpivirine is primarily metabolised by cytochrome P450 (CYP3A).
Rilpivirin presnavlja predvsem citokrom P450 (CYP3A).
Rilpivirine must not be used in combination with products containing St John’s wort as co-administration may result in loss of therapeutic effect of rilpivirine (see section 4.3).
Rilpivirina se ne sme uporabljati v kombinaciji s pripravki, ki vsebujejo šentjanževko, saj lahko pride izgube terapevtskega učinka rilpivirina (glejte poglavje 4.3).
Rilpivirine resistance mutations were observed in 62.5% (5/8) of subjects with virological failure.
Odpornost rilpivirina na mutacije so opazili pri 62,5% (5/8) preiskovancev z virološkim neuspehom.
Rilpivirine was also administered with food in the evening and 4 hours after dinner with Exviera + ombitasvir/paritaprevir/ritonavir in the study.
V študiji je bil rilpivirin uporabljen tudi s hrano zvečer in 4 ure po večerji z zdravilom Exviera + kombinacijo ombitasvir/paritaprevir/ritonavir.
Rilpivirine-containing regimen
Režim, ki vsebuje rilpivirin
Rilpivirine-containing regimens
Režimi, ki vsebujejo rilpivirin
Rilpivirine-resistant strains were selected in cell culture starting from wild-type HIV-1 of different origins and subtypes as well as NNRTI resistant HIV-1.
V celični kulturi so bili izbrani na rilpivirin rezistentni sevi, od divjega tipa virusa HIV-1 različnih izvorov in podtipov ter proti NNRTI rezistenten virus HIV-1.
Rilpivirine-treated
Zdravljeni z rilpivirinom
Rilpivirine2
rilpivirin
Rilpivirine:
emtricitabin:
Rilpivirine:
zdravila
Rilpivirine: AUC: ↑ 12%
rilpivirin: AUC: ↑ 12
Rilpivirine: AUC: ↑ 13%
rilpivirin: AUC: ↑ 13
Rilpivirine: AUC: ↑ 130%
rilpivirin: AUC: ↑ 130
Rilpivirine: AUC: ↑ 16%*
rilpivirin: AUC: ↑ 16
Rilpivirine: AUC: ↑ 49%
rilpivirin: AUC: ↑ 49
Rilpivirine: AUC: ↑ 52%
rilpivirin: AUC: ↑ 52
Rilpivirine: AUC: ↑ 78%
rilpivirin: AUC: ↑ 78
Rilpivirine: AUC: ↓ 40%
rilpivirin: AUC: ↓ 40
Rilpivirine: AUC: ↓ 42%
rilpivirin: AUC: ↓ 42
Rilpivirine: AUC: ↓ 5%
rilpivirin: AUC: ↓ 5
Rilpivirine: AUC: ↓ 76%
rilpivirin: AUC: ↓ 76
Rilpivirine: AUC: ↓ 80%
rilpivirin: AUC: ↓ 80
Rilpivirine: AUC: ↔
rilpivirin: AUC: ↔
Rilpivirine: AUC: ↔* Cmin: ↔* Cmax: ↔*
rilpivirin: AUC: ↔* Cmin: ↔* Cmax: ↔
rilpivirine: If you are taking rilpivirine, your doctor will monitor you closely.
Rilpivirin: Če jemljete rilpivirin, bo vaš zdravnik zdravljenje natančno spremljal.