natgillin/translations-raw huggingface dataset:
Since sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg dose should be considered.
Pri bolnikih z jetrno okvaro (npr. s cirozo) se očistek sildenafila zmanjša, zato je priporočeni začetni odmerek 25 mg.
Since sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg dose should be considered.
Pri bolnikih z okvaro jeter (npr. ciroza) je očistek sildenafila zmanjšan, zato je priporočeni začetni odmerek 25 mg.
Since sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg dose should be considered.
Pri bolnikih z okvaro jeter (npr. ciroza) je očistek sildenafila zmanjšan, zato je priporočljivi začetni odmerek 25 mg.
Since sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg dose should be considered.
Pri bolnikih z okvaro jeter (npr. s cirozo) je očistek sildenafila zmanjšan, zato je priporočljivi začetni odmerek 25 mg.
Since sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis), a 25 mg dose should be considered.
Pri bolnikih z okvaro jeter (npr. ciroza) je očistek sildenafila zmanjšan, zato je priporočljivi začetni odmerek 25 mg.
Since Sirturo has been granted a conditional approval, the company that markets Sirturo will provide additional data on the medicine’s benefits and safety when used with different combinations of medicines.
Ker je zdravilo Sirturo pridobilo pogojno dovoljenje za promet, bo družba, ki ga trži, zagotovila dodatne podatke o koristih in varnosti zdravila pri njegovi uporabi skupaj z različnimi kombinacijami zdravil.
Since some of these side effects are serious, ask your or your child’s doctor to explain their warning signs.
Ker so nekateri od teh neželenih učinkov resni, se o njihovih opozorilnih znakih posvetujte s svojim ali otrokovim zdravnikom.
Since SSRIs affect platelet activation and increase the risk of bleeding, the concomitant administration of SSRIs with clopidogrel should be undertaken with caution.
Selektivni zaviralci privzema serotonina vplivajo na aktivacijo trombocitov in povečajo nevarnost krvavitve, zato je ob sočasnem jemanju selektivnih zaviralcev privzema serotonina in klopidogrela potrebna previdnost.
Since Strensiq has been approved under exceptional circumstances, the company that markets Strensiq will set up a registry of patients with hypophosphatasia to collect information on the disease and on the long-term safety and effectiveness of Strensiq.
Ker je zdravilo Strensiq pridobilo dovoljenje za promet v izjemnih okoliščinah, bo družba, ki ga trži, vzpostavila register bolnikov s hipofosfatazijo, s pomočjo katerega bo zbirala podatke o bolezni in dolgotrajni varnosti ter učinkovitosti zdravila Strensiq.
Since Sycrest works primarily in the brain, interference from other medicines (or alcohol) that work in the brain could occur due to an additive effect on brain function.
Ker zdravilo Sycrest deluje predvsem v možganih, lahko pride pri jemanju drugega zdravila (ali uživanju alkohola), ki tudi deluje v možganih, do motenj delovanja zdravila Sycrest zaradi seštevanja učinkov na delovanje možganov.
Since systemic exposure to trabectedin is probably increased due to hepatic impairment and therefore the risk of hepatotoxicity might be increased, patients with clinically relevant liver diseases, such as active chronic hepatitis, must be closely monitored and the dose adjusted if needed.
Ker je sistemska izpostavljenost trabektedinu verjetno večja zaradi okvarjenega delovanja jeter in je zato tveganje hepatotoksičnosti večje, je treba bolnike s klinično pomembnimi boleznimi jeter, kot je aktivni kronični hepatitis, skrbno nadzirati in po potrebi prilagoditi odmerek.
Since Tagrisso has been granted a conditional approval, the company that markets Tagrisso will provide the findings of a study comparing Tagrisso with platinum-based chemotherapy (standard treatment for NSCLC).
Ker je zdravilo Tagrisso pridobilo pogojno dovoljenje za promet, bo družba, ki trži zdravilo Tagrisso, predložila izsledke študije, v kateri primerjajo zdravilo Tagrisso s kemoterapijo na osnovi platine (standardnim zdravljenjem za NSCLC).
Since technetium (99mTc) tilmanocept contains a small amount of radioactivity it can make parts of the body areas visible to doctors during tests to help them see if the cancer has spread to places called ‘lymph nodes’ that are found near tumours.
Ker tehnecijev (99mTc) tilmanocept vsebuje majhno količino radioaktivnosti, zdravnikom omogoča pregledovanje delov telesa med preiskavami, s čimer ugotovijo, ali se je rak razširil na bezgavke v okolici tumorjev.
Since telbivudine is eliminated primarily by renal excretion, co-administration of Sebivo with substances that affect renal function (such as aminoglycosides, loop diuretics, platinum compounds, vancomycin, amphotericin B) may affect plasma concentrations of telbivudine and/or the co- administered substance.
Ker se telbivudin izloča večinoma preko ledvic, lahko sočasna uporaba zdravila Sebivo s snovmi, ki vplivajo na delovanje ledvic (kot so aminoglikozidi, diuretiki Henlejeve zanke, pripravki s platino, vankomicin in amfotericin B), vpliva na plazemske koncentracije telbivudina in/ali sočasno uporabljanih zdravil.
Since tenofovir disoproxil can cause renal toxicity, close monitoring of renal function is recommended in any individual with renal impairment treated with receiving Emtricitabine/Tenofovir disoproxil Zentiva (see sections 4.2, 4.4 and 5.2).
Ker lahko dizoproksiltenofovirat povzroči ledvično toksičnost, se priporoča skrbno nadziranje ledvične funkcije pri vseh posameznikih z ledvično okvaro, ki se zdravijo z zdravilom Emtricitabin/dizoproksiltenofovirat Zentiva (glejte poglavja 4.2, 4.4 in 5.2).
Since tenofovir disoproxil fumarate can cause renal toxicity, close monitoring of renal function is recommended in adult patients with renal impairment treated with Viread (see sections 4.2, 4.4 and 5.2).
Ker lahko dizoproksiltenofovirijev fumarat povzroči ledvično toksičnost, se priporoča skrbno nadziranje ledvične funkcije pri odraslih bolnikih z ledvično okvaro, ki se zdravijo z zdravilom Viread (glejte poglavja 4.2, 4.4 in 5.2).
Since tenofovir disoproxil fumarate can cause renal toxicity, close monitoring of renal function is recommended in any patient with renal impairment treated with Eviplera (see sections 4.2, 4.4 and 5.2).
Ker lahko dizoproksiltenofovirijev fumarat povzroči ledvično toksičnost, se priporoča skrbno nadziranje ledvične funkcije pri vseh bolnikih z ledvično okvaro, ki se zdravijo z zdravilom Eviplera (glejte poglavja 4.2, 4.4 in 5.2).
Since tenofovir disoproxil fumarate can cause renal toxicity, close monitoring of renal function is recommended in any patient with renal impairment treated with Stribild (see sections 4.2, 4.4 and 5.2).
Ker lahko dizoproksiltenofovirijev fumarat povzroči ledvično toksičnost, se priporoča skrbno nadziranje ledvične funkcije pri vseh bolnikih z ledvično okvaro, ki se zdravijo z zdravilom Stribild (glejte poglavja 4.2, 4.4 in 5.2).
Since tenofovir is primarily eliminated by the kidneys, co-administration of tenofovir disoproxil fumarate with medicinal products that reduce renal function or compete for active tubular secretion via transport proteins hOAT 1, hOAT 3 or MRP 4 (e.g. cidofovir) may increase serum concentrations of tenofovir and/or the co-administered medicinal products.
Tenofovir se izloča predvsem preko ledvic, zato lahko sočasna uporaba dizoproksiltenofovirijevega fumarata in zdravil, ki zmanjšujejo delovanje ledvic ali tekmujejo za aktivno tubularno sekrecijo preko transportnih beljakovin hOAT 1, hOAT 3 ali MRP 4 (npr. cidofovir), poveča serumske koncentracije tenofovirja in/ali sočasno uporabljenih zdravil.
Since the 97.5% confidence interval (stratum adjusted Mantel-Haenszel test) of the difference in CR0-24h between palonosetron 20 µg/kg and ondansetron was [-11.7%, 12.4%], the 20 µg/kg palonosetron dose demonstrated non-inferiority to ondansetron.
Ker je bil 97,5-odstotni interval zaupanja (stratifikacija prilagojena Mantel-Haenszelovemu testu) razlike v CR0-24h med palonosetronom 20 µg/kg in ondansetronom [-11,7 %, 12,4 %], je bil palonosetron v odmerku 20 µg/kg ne-manjvreden ondansetronu.
Since the brinzolamide component of SIMBRINZA and its metabolite are excreted predominantly by the kidney, SIMBRINZA is contraindicated in such patients (see sections 4.3).
Ker se brinzolamid iz zdravila SIMBRINZA in njegov presnovek izločata predvsem skozi ledvice, je zdravilo SIMBRINZA kontraindicirano pri teh bolnikih (glejte poglavje 4.3).
Since the efficacy of Gardasil 9 could not be evaluated against placebo, the following exploratory analyses were conducted.
Ker učinkovitosti cepiva Gardasil 9 ni bilo mogoče ovrednotiti v primerjavi s placebom, so bile izvedene naslednje eksplorativne analize.
Since the existing wording restricted the warning only to the use of sofosbuvir + daclatasvir and amiodarone, it became outdated and had to be modified.
Ker je bilo v obstoječem besedilu opozorilo omejeno le na uporabo sofosbuvirja + daklatasvirja in amiodarona, je postalo zastarelo in ga je bilo treba posodobiti.
Since the Hib capsular polysaccharide antigen is excreted in the urine, a positive urine test can be observed within 1-2 weeks following vaccination.
Kapsularni polisaharidni antigen Hib se izloča v urin, zato se lahko v 1 do 2 tednih po cepljenju pojavi pozitiven izvid urinskega testa.
Since the I-Neb AAD nebuliser can be used for Ventavis 10 microgram/ ml and Ventavis 20 microgram/ ml, the table below provides a summary of the user instructions of the I-Neb for the 2 concentrations of Ventavis:
Ker se lahko nebulator I-Neb AAD uporablja za zdravilo Ventavis 10 mikrogramov/ml in zdravilo Ventavis 20 mikrogramov/ml, je v naslednji preglednici povzetek navodil za uporabo nebulatorja I-Neb za dve koncentraciji zdravila Ventavis:
Since the I-Neb AAD system can be used for Ventavis 10 microgram/ ml and Ventavis 20 microgram/ ml, the table below provides a summary of the user instructions of the I-Neb for the 2 concentrations of Ventavis:
Ker se lahko nebulator I-Neb AAD uporablja za zdravilo Ventavis 10 mikrogramov/ml in zdravilo Ventavis 20 mikrogramov/ml, je v naslednji preglednici povzetek navodil za uporabo nebulatorja I-Neb za dve koncentraciji zdravila Ventavis:
Since the introduction of entacapone into the market, isolated cases of NMS have been reported, especially following abrupt reduction or discontinuation of entacapone and other concomitant dopaminergicmedicinal products.
Od uvedbe entakapona na tržišče poročajo o posameznih primerih NMS, zlasti po nenadnem zmanjšanju ali ukinitvi entakapona in drugih sočasnih dopaminergičnih zdravil.
Since the magnitude of QT and PR prolongation increases with increasing concentrations of saquinavir, the recommended dose of ritonavir-boosted Invirase should not be exceeded.
Ker se s povečanjem koncentracij sakvinavirja podaljšata tudi intervala QT in PR, se priporočenega odmerka zdravila Invirase s podporno terapijo z ritonavirjem ne sme preseči.
Since the medicine radiolabelled with Cuprymina is handled by a nuclear medicine doctor under strictly controlled conditions, there is only a very small chance of possible overdose.
Ker z zdravilom, radioaktivno označenim z radiofarmacevtskim predhodnikom Cuprymina, ravna le zdravnik nuklearne medicine pod strogo nadzorovanimi pogoji, obstaja zelo majhno tveganje za morebiten prevelik odmerek.
Since the orodispersible tablet is moisture sensitive, it should be taken immediately after opening the blister.
Ker je orodisperzibilna tableta občutljiva za vlago, jo mora bolnik vzeti takoj po tistem, ko odpre pretisni omot.
Since the patient populations treated in the three indications are not comparable and bleeding events are distributed over several System Organ Classes (SOC), a summary description of major and any bleeding are broken down by indication and given in tables 5 and 6 below.
Ker populaciji bolnikov, ki prejemajo zdravljenje pri teh treh indikacijah, nista primerljivi in sodijo krvavitve v več skupin organskih sistemov, je povzetek velikih in vseh krvavitev razdeljen po indikacijah.
Since the possibility of increased risk of cancer development in patients with newly diagnosed dysplasia treated with infliximab is not established, the risk and benefits to the individual patients must be carefully reviewed and consideration should be given to discontinuation of therapy.
Ker še ni ugotovljena verjetnost povečanega tveganja za nastanek karcinoma pri bolnikih z na novo diagnosticirano displazijo, ki se zdravijo z infliksimabom, morate skrbno oceniti tveganje in koristi za posameznega bolnika in zdravljenje ukiniti, če je treba.
Since the possibility of increased risk of cancer development in patients with newly diagnosed dysplasia treated with infliximab is not established, the risk and benefits to the individual patients must be carefully reviewed and consideration should be given to discontinuation of therapy.
Ker še ni ugotovljena verjetnost povečanega tveganja za nastanek karcinoma pri bolnikih z nanovo diagnosticirano displazijo, ki se zdravijo z infliksimabom, morate skrbno oceniti tveganje in koristi za posameznega bolnika in zdravljenje ukiniti, če je potrebno.
Since the possibility of increased risk of cancer development in patients with newly diagnosed dysplasia treated with Remicade is not established, the risk and benefits to the individual patients must be carefully reviewed and consideration should be given to discontinuation of therapy.
Ker še ni ugotovljena verjetnost povečanega tveganja za nastanek karcinoma pri bolnikih z nanovo diagnosticirano displazijo, ki se zdravijo z zdravilom Remicade, morate skrbno oceniti tveganje in koristi za posameznega bolnika in zdravljenje ukiniti, če je potrebno.
Since the primary therapeutic effect of Starlix is to reduce mealtime glucose, (a contributor to HbA1c), the therapeutic response to Starlix may also be monitored with 1–2 hour post-meal glucose.
Ker je primarni terapevtski učinek zdravila Starlixzniževanje glukoze v času obroka (ki je eden od dejavnikov, ki prispevajo k HbA1c), lahko terapevtski odziv na zdravilo Starlix spremljamo tudi z glukozo 1-2 uri po obroku.
Since the primary therapeutic effect of Trazec is to reduce mealtime glucose, (a contributor to HbA1c), the therapeutic response to Trazec may also be monitored with 1–2 hour post-meal glucose.
Ker je primarni terapevtski učinek Trazeca zniževanje glukoze v času obroka (ki je eden od dejavnikov, ki prispevajo k HbA1c), lahko terapevtski odziv na Trazec spremljamo tudi z glukozo
Since the protection of piglets is ensured by colostrum intake, each piglet should ingest a sufficient quantity of colostrum within 6 hours of birth.
Ker zaščito pujskov zagotavlja zaužitje kolostruma, bi moral vsak pujsek zaužiti zadostno količino kolostruma v prvih šestih urah po rojstvu.
Since the proteolytic enzymes responsible for Oncaspar metabolism are ubiquitously distributed in tissues the exact role of the liver is unknown: however any decrease in liver function is not expected to present clinical relevant problems in the use of Oncaspar.
Ker so za presnovo zdravila Oncaspar odgovorni proteolizni encimi, ki so porazdeljeni v vseh tkivih, natančna vloga jeter ni znana, vendar se ne pričakuje, da zmanjšanje delovanja jeter predstavlja klinično pomembno težavo pri uporabi zdravila Oncaspar.
Since the recommended dose of
Protimikobakterijska zdravila
Since the recommended dose of
uporaba rifampicina z zdravilom
Since the recommended dose of dolutegravir is 50 mg twice daily when co-administered with etravirine (without boosted protease inhibitors), efavirenz, nevirapine, rifampicin, tipranavir/ritonavir, carbamazepine, phenytoin, phenobarbital and St. John’s wort, the use of Triumeq is not recommended for patients taking these medicines (see section 4.5).
Ker je priporočeni odmerek dolutegravirja med sočasno uporabo z etravirinom (brez okrepljenih zaviralcev proteaz), efavirenzom, nevirapinom, rifampicinom tipranavirjem/ritonavirjem, karbamazepinom, fenitoinom, fenobarbitalom in šentjanževko 50 mg dvakrat na dan, se uporaba zdravila Triumeq pri bolnikih, ki jemljejo ta zdravila, ne priporoča (glejte poglavje 4.5).
Since the recommended dose of dolutegravir is 50 mg twice daily when co-administered with St. John’s wort, DTG/ABC/3TC FDC is not recommended.
Ker je priporočeni odmerek dolutegravirja med sočasno uporabo s šentjanževko 50 mg dvakrat na dan, uporaba DTG/ABC/3TC FDC ni priporočljiva.
Since the relationship between exposure and drug activity is unclear, the monitoring of response to therapy (e.g., cholesterol levels) is recommended.
Ker je povezava med izpostavljenostjo in delovanjem zdravila nejasna, se priporo ča spremljanje odziva na zdravljenje (npr. kontrola koncentracije holesterola v krvi).
Since the relationship between exposure and drug activity is unclear, the monitoring of response to therapy (e.g., cholesterol levels) is recommended.
Ker je povezava med izpostavljenostjo in delovanjem zdravila nejasna, se priporoča spremljanje odziva na zdravljenje (npr. kontrola koncentracije holesterola v krvi).
Since the renal clearance of lopinavir and ritonavir is negligible, increased plasma concentrations are not expected in patients with renal impairment.
Ledvični očistek lopinavirja in ritonavirja je zanemarljiv, zato pri bolnikih z okvaro ledvic ni pričakovati povečane koncentracije v plazmi.
Since the use of factor IX complex concentrates has historically been associated with the development of thromboembolic complications, the risk being higher in low purity preparations, the use of factor IX-containing products may be potentially hazardous in patients with signs of fibrinolysis and in patients with disseminated intravascular coagulation (DIC).
Ker so uporabo kompleksnih koncentratov faktorja IX v preteklosti povezovali z razvojem tromboemboličnih zapletov, z višjim tveganjem pri manj prečiščenih zdravilih, je lahko uporaba zdravil, ki vsebujejo faktor IX, potencialno tvegana pri bolnikih z znaki fibrinolize ter pri bolnikih z diseminirano intravaskularno koagulacijo (DIK).
Since the veterinary medicinal product completely eliminates egg production, it breaks the flea life cycle.
Ker to zdravilo za uporabo v veterinarski medicini v celoti zavira produkcijo jajčec, s tem prekine življenjski ciklus bolh.
Since the VLPs contain no viral DNA, they cannot infect cells, reproduce or cause disease.
Ker virusu podobni delci ne vsebujejo virusne DNA, ne morejo okužiti celic, se razmnoževati ali povzročiti bolezni.
Since there are no clinical data on administration of tadalafil to patients with veno-occlusive disease, administration of tadalafil to such patients is not recommended.
Ker za bolnike z veno-okluzivno boleznijo podatkov o uporabi tadalafila ni, se uporaba tadalafila pri teh bolnikih ne priporoča.
Since there are no clinical data on the safety of tadalafil in these patients, the use of tadalafil is not recommended.
Ker za te bolnike podatkov o varnosti tadalafila ni, se uporaba tadalafila pri njih ne priporoča.
Since there is a potential for an increase in dose- related adverse events, a decrease in the dose of pioglitazone may be needed when gemfibrozil is concomitantly administered.
Ker obstaja možnost povečanja od odmerka odvisnih neželenih učinkov, bo morda ob sočasnem dajanju gemfibrozila potrebno znižati odmerek pioglitazona.
Since there is a potential for an increase in dose- related adverse events, a decrease in the dose of pioglitazone may be needed when gemfibrozil is concomitantly administered.
Ker obstaja možnost povečanja od odmerka odvisnih neželenih učinkov, bo morda ob sočasnem dajanju gemfibrozila treba znižati odmerek pioglitazona.
Since there is limited information in the elderly, caution should be exercised in these patients.
Ker so podatki o uporabi pri starejših bolnikih omejeni, je pri teh bolnikih potrebna previdnost.
Since there is no available data in patients with mild to moderate liver impairment, Siklos should be used with caution.
Ker ni podatkov za bolnike z blago do zmerno jetrno okvaro, je treba zdravilo Siklos uporabljati previdno.
Since there is no significant impact of nucleoside and nucleotide analogues on the P450 enzyme system no dosage adjustment of Aptivus is required when co-administered with these agents.
Ker nukleozidni in nukleotidni analogi na encimski sistem P450 pomembneje ne vplivajo, odmerka zdravila Aptivus pri sočasnem dajanju s temi zdravili ni treba prilagoditi.
Since there was no consistent increase in plasma platelet-derived growth factor-BB concentrations above pre-treatment concentra- tions, following 14 consecutive daily topical applications to ulcers in man, carcinogenesis and reproductive toxicity studies have not been conducted with REGRANEX.
Ker pri ljudeh po 14 dnevnem zaporednem nanašanju gela REGRANEX na razjede, ni bilo enotnih podatkov o povečanju plazemskih koncentracij rastnega dejavnika iz trombocitov-BB v primerjavi s koncentracijami pred zdravljenjem, študij kancerogenosti in vpliva na sposobnost razmnoževanja niso opravili.
Since these patients are amenorrhoeic and have low endogenous oestrogen secretion, treatment can commence at any time.
Ker so te bolnice amenoreične in imajo nizko sekrecijo endogenega estrogena, se lahko zdravljenje začne kadar koli.
Since these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency which is therefore categorised as not known.
Ker se poročila o teh reakcijah poročajo prostovoljno in velikost te populacije ni znana, ne moremo realno oceniti njihove pogostnosti, zato smo jih razvrstili kot neznano.
Since thiotepa is mainly metabolized through the liver, caution needs to be exercised when thiotepa is used in patients with pre-existing impairment of liver function, especially in those with severe hepatic impairment.
Ker se tiotepa presnavlja predvsem v jetrih, je potrebna previdnost, ko se tiotepa uporablja pri bolnikih s predhodno obstoječo okvaro jetrne funkcije, zlasti pri bolnikih s hudo okvaro jeter.
Since thiotepa is mainly metabolized through the liver, caution needs to be observed when thiotepa is used in patients with pre-existing impairment of liver function, especially in those with severe hepatic impairment.
Ker se tiotepa predvsem presnavlja v jetrih, je potrebna previdnost, ko se tiotepa uporablja pri bolnikih s predhodno obstoječo okvaro jetrne funkcije, zlasti pri bolnikih s hudo okvaro jeter.
Since this decrease related to age is smaller than the observed inter-subject variability of 30-40 % in exposure parameters for sufentanil, this effect is not considered to be of clinical relevance, particularly given that Zalviso is only used on an ‘as-needed’ basis.
Ker je zmanjšanje, povezano s starostjo, manjše od opažene variabilnosti med osebami, ki pri parametrih izpostavljenosti za sufentanil znaša 30 do 40%, ta učinek ne velja za klinično pomembnega, zlasti glede na to, da se zdravilo Zalviso uporablja le na podlagi potrebe.
since this dose adjustment
nezadostno.
Since this is below the predefined threshold of one infection per year, this indicates that the medicine is effective as replacement therapy.
Ker je ta vrednost nižja od mejne vrednosti, ki je enaka eni okužbi na leto, to kaže, da je zdravilo kot nadomestno zdravljenje učinkovito.
Since this is below the predefined threshold of one infection per year, this indicates that the medicine is effective in replacing the patient’s antibodies.
Ker je ta vrednost nižja od vnaprej določene mejne vrednosti, enake eni okužbi na leto, to kaže, da je zdravilo učinkovito pri nadomeščanju bolnikovih protiteles.
Since this may be of clinical significance this co- administration should only be used when the benefits clearly outweigh the risks, with close monitoring of amphotericin B desoxycholate toxicities (see section 4.4).
Ker je to lahko klinično pomembno, je sočasno dajanje dovoljeno le, ko koristi jasno odtehtajo tveganja, in ob natančnem spremljanju toksičnosti amfotericina B deoksikolata (glejte poglavje 4.4).