natgillin/translations-raw huggingface dataset:
As demonstrated in 605 patients with COPD in a 26-week, double-blind, placebo-controlled Phase III study, there was no clinically relevant difference in the development of arrhythmic events monitored over 24 hours, at baseline and up to 3 times during the 26-week treatment period, between patients receiving recommended doses of Hirobriz Breezhaler treatment and those patients who received placebo or treatment with tiotropium.
Kot se je pokazalo pri 605 bolnikih s KOPB v 26-tedenski, dvojno slepi, s placebom kontrolirani študiji faze III, med bolniki, ki so prejemali priporočene odmerka zdravila Hirobriz Breezhaler, in tistimi, ki so prejemali placebo ali zdravljenje s tiotropijem, ni prišlo do klinično pomembnih razlik glede razvoja aritmičnih dogodkov, ki so jih spremljali 24 ur ob izhodišču, nato pa še do 3-krat v 26- tedenskem obdobju zdravljenja.
As demonstrated in 605 patients with COPD in a 26-week, double-blind, placebo-controlled Phase III study, there was no clinically relevant difference in the development of arrhythmic events monitored over 24 hours, at baseline and up to 3 times during the 26-week treatment period, between patients receiving recommended doses of Onbrez Breezhaler treatment and those patients who received placebo or treatment with tiotropium.
Kot se je pokazalo pri 605 bolnikih s KOPB v 26-tedenski, dvojno slepi, s placebom kontrolirani študiji faze III, med bolniki, ki so prejemali priporočene odmerka zdravila Onbrez Breezhaler, in tistimi, ki so prejemali placebo ali zdravljenje s tiotropijem, ni prišlo do klinično pomembnih razlik glede razvoja aritmičnih dogodkov, ki so jih spremljali 24 ur ob izhodišču, nato pa še do 3-krat v 26- tedenskem obdobju zdravljenja.
As demonstrated in 605 patients with COPD in a 26-week, double-blind, placebo-controlled Phase III study, there was no clinically relevant difference in the development of arrhythmic events monitored over 24 hours, at baseline and up to 3 times during the 26-week treatment period, between patients receiving recommended doses of Oslif Breezhaler treatment and those patients who received placebo or treatment with tiotropium.
Kot se je pokazalo pri 605 bolnikih s KOPB v 26-tedenski, dvojno slepi, s placebom kontrolirani študiji faze III, med bolniki, ki so prejemali priporočene odmerka zdravila Oslif Breezhaler, in tistimi, ki so prejemali placebo ali zdravljenje s tiotropijem, ni prišlo do klinično pomembnih razlik glede razvoja aritmičnih dogodkov, ki so jih spremljali 24 ur ob izhodišču, nato pa še do 3-krat v 26- tedenskem obdobju zdravljenja.
As demonstrated in a dose- ranging evaluation in 113 HIV-negative healthy male and female volunteers, ritonavir increases AUC0- 12h, Cmax and Cmin and decreases the clearance of tipranavir.
Med določanjem razpona odmerka pri 113 HIV-negativnih zdravih prostovoljcih moškega in ženskega spola se je pokazalo, da ritonavir poveča AUC0-12h, Cmax in Cmin tipranavirja in zmanjša njegov očistek.
As determined by AUC, food consumption does not affect the overall extent of absorption of telmisartan.
Kot je bilo ugotovljeno z AUC uživanje hrane ne vpliva na splošni obseg absorpcije telmisartana.
As diabetes mellitus or worsening of pre-existing diabetes mellitus have been seen with patients taking this medicine, your doctor should check for signs of high blood sugar.
Med jemanjem tega zdravila so pri bolnikih opazili sladkorno bolezen ali njeno poslabšanje, zato bo vaš zdravnik preverjal znake zvišane koncentracije sladkorja v krvi.
As diabetes mellitus or worsening of pre-existing diabetes mellitus have been seen with patients taking this medicine, your doctor should check for signs of high blood sugar.
Med jemanjem tega zdravila so pri bolnikih opazili sladkorno bolezen ali njeno poslabšanje, zato bo zdravnik preverjal, če imate znake zvečane koncentracije sladkorja v krvi.
As didanosine is administered on
Ker se didanozin daje na prazen
As dimethyl fumarate and monomethyl fumarate are metabolised by esterases, without the involvement of the CYP450 system, evaluation of phamacokinetics in individuals with hepatic impairment was not conducted.
Ker dimetilfumarat in monometil fumarat presnavljajo esteraze brez udeležbe sistema CYP450, ocene famakokinetike pri posameznikih z okvaro jeter niso izvedli.
As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they might be affected by Revatio, before driving or using machines.
V kliničnih preskušanjih s sildenafilom so poročali o omotici in spremembah vida, zato morajo biti bolniki pred vožnjo ali upravljanjem s stroji seznanjeni, kako lahko zdravilo Revatio nanje vpliva.
As dosage adjustment of Combivir is not possible separate preparations of zidovudine and lamivudine should be used.
Ker z zdravilom Combivir prilagajanje odmerka posamezne učinkovine ni možno, je potrebno uporabiti zidovudin in lamivudin kot samostojni zdravili.
As dosage adjustment of Combivir is not possible, separate preparations of zidovudine and lamivudine should be used.
Ker z zdravilom Combivir prilagajanje odmerka posamezne učinkovine ni možno, je potrebno uporabiti zidovudin in lamivudin kot samostojni zdravili.
As dosage adjustment of Lamivudine/Zidovudine Teva is not possible separate preparations of zidovudine and lamivudine should be used.
Ker z zdravilom Lamivudin/zidovudin Teva prilagajanje odmerka posamezne učinkovine ni možno, je potrebno uporabiti zidovudin in lamivudin kot samostojni zdravili.
As dosage adjustment of Lamivudine/Zidovudine Teva is not possible, separate preparations of zidovudine and lamivudine should be used.
Ker z zdravilom Lamivudin/zidovudin Teva prilagajanje odmerka posamezne učinkovine ni možno, je potrebno uporabiti zidovudin in lamivudin kot samostojni zdravili.
As dose increases the bioavailability decreases.
S povečevanjem odmerka se biološka uporabnost zmanjšuje.
As dose reduction is not possible with Triumeq, the separate preparations of dolutegravir, abacavir or lamivudine should be used when this is judged necessary.
Ker pri zdravilu Triumeq prilagajanje odmerka ni mogoče, je treba uporabljati ločena zdravila z dolutegravirjem, abakavirjem ali lamivudinom, če se presodi, da je to potrebno.
As doxorubicin is metabolised by the liver and excreted in the bile, dose modification should not be required.
Ker se doksorubicin presnavlja v jetrih in izloča z žolčem, naj prilagoditev odmerka ne bi bila potrebna.
as dual oral therapy in combination with
kot del peroralnega zdravljenja z dvema zdraviloma v kombinaciji
as dual oral therapy in combination with
kot dvojno peroralno zdravljenje v kombinaciji
as dual oral therapy in combination with
kot dvojno peroralno zdravljenje v kombinaciji:
as dual oral therapy in combination with
kot dvotirno peroralno zdravljenje v kombinaciji
As dual oral therapy in combination with
kot dvotirno peroralno zdravljenje v kombinaciji:
as dual oral therapy in combination with a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea;
kot dvojno peroralno zdravljenje v kombinaciji: s sulfonilsečnino, le pri odraslih bolnikih, ki ne prenašajo metformina ali je metformin pri njih kontraindiciran, z nezadostnim nadzorom glikemije kljub najvišjemu toleriranemu odmerku monoterapije s sulfonilsečnino.
As Efficib contains metformin hydrochloride, the treatment should be discontinued 48 hours before elective surgery with general, spinal or epidural anaesthesia.
Zdravilo Efficib vsebuje metforminijev klorid, zato je treba zdravljenje prekiniti 48 ur pred elektivno operacijo pod splošno, spinalno ali epiduralno anestezijo.
As Empliciti will be given to you by a healthcare professional, it is unlikely you will be given too much.
Zdravilo Empliciti vam bo dal zdravstveni delavec, zato je malo verjetno, da boste prejeli prevelik odmerek.
As emtricitabine / tenofovir disoproxil may cause renal damage monitoring of renal function is recommended (see section 4.4 ).
Ker lahko emtricitabin / dizoproksiltenofovirat povzroči ledvično poškodbo, se priporoča nadziranje ledvične funkcije (glejte poglavje 4.4).
As Emtricitabine/Tenofovir disoproxil Zentiva contains emtricitabine and tenofovir disoproxil , any interactions that have been identified with these agents individually may occur with Emtricitabine/Tenofovir disoproxil Zentiva.
Zdravilo Emtricitabin/dizoproksiltenofovirat Zentiva vsebuje emtricitabin in dizoproksiltenofovirat, zato se pri uporabi zdravila Emtricitabin/dizoproksiltenofovirat Zentiva lahko pojavijo katerekoli interakcije, ki so jih opazili pri uporabi teh posameznih učinkovin.
As Epclusa contains sofosbuvir and velpatasvir, any interactions that have been identified with these active substances individually may occur with Epclusa.
Zdravilo Epclusa vsebuje sofosbuvir in velpatasvir, zato se pri uporabi zdravila Epclusa lahko pojavijo katere koli interakcije, ki so jih opazili pri uporabi teh posameznih zdravilnih učinkovin.
As esomeprazole is one enantiomer of omeprazole it is reasonable to advise about interactions reported with omeprazole.
Esomeprazol je enantiomer omeprazola, zato je upravičeno opozoriti na medsebojna delovanja, opisana pri omeprazolu.
As Eucreas contains metformin, the treatment should be discontinued 48 hours before elective surgery with general anaesthesia and should not usually be resumed earlier than 48 hours afterwards.
Zdravilo Eucreas vsebuje metformin, zato je treba zdravljenje z njim prekiniti 48 ur pred načrtovanim operacijskim posegom s splošno anestezijo, ponovno pa se ga sme uvesti šele 48 ur po posegu.
As Eviplera contains emtricitabine, rilpivirine hydrochloride and tenofovir disoproxil fumarate, any interactions that have been identified with these active substances individually may occur with Eviplera.
Zdravilo Eviplera vsebuje emtricitabin, rilpivirinijev klorid in dizoproksiltenofovirijev fumarat zato se pri uporabi zdravila Eviplera lahko pojavijo katerekoli interakcije, ki so jih opazili pri uporabi teh posameznih učinkovin.
As Eviplera may cause renal damage, monitoring of renal function is recommended (see sections 4.4 and 4.8 Summary of the safety profile).
Ker lahko zdravilo Eviplera povzroči ledvično poškodbo, se priporoča nadziranje ledvične funkcije (glejte poglavji 4.4 in 4.8 Povzetek varnostnega profila).
As EVOTAZ contains atazanavir and cobicistat, any interactions that have been identified with these active substances individually may occur with EVOTAZ.
Zdravilo EVOTAZ vsebuje atazanavir in kobicistat, zato pri uporabi zdravila EVOTAZ lahko pričakujemo pojav vseh interakcij, ki so bile ugotovljene pri uporabi posameznih zdravilnih učinkovin.
As examples
Primeri:
As expected for a prostacyclin, iloprost produced haemodynamic effects (vasodilatation, reddening of skin, hypotension, inhibition of platelet function, respiratory distress) and general signs of intoxication such as apathy, gait disturbances, and postural changes.
Kot običajno pri prostaciklinih, je iloprost povzročil hemodinamske učinke (vazodilatacijo, pordelost kože, hipotenzijo, zaviranje delovanja trombocitov, dihalno stisko) in splošne znake zastrupitve, kot so apatija, motnje ravnotežja in motnje zaradi spremembe položaja telesa.
As expected from the pharmacodynamic effects, escalating doses of desoxycortone are associated with a dose-related trend for increased serum sodium, and decreased blood urea nitrogen, serum potassium and urine specific gravity.
Kot se pričakuje zaradi farmakodinamičnega učinka je večanje odmerkov dezoksikortona povezano z od odmerka odvisnim trendom povečega natrija v serumu in zmanjšanja sečninskega dušika v krvi, kalija v serumu in specifične teže urina.
As expected with ocular steroid treatment and intravitreal injections, increases in intraocular pressure (IOP) may be seen.
Po pričakovanjih se lahko pri zdravljenju z očesnim steroidom in intravitrealnem injiciranju pojavi zvišanje očesnega tlaka (IOP – intraocular pressure).
As expected, patients with poor performance status (PS > 1) have a lower response rate and an increased incidence of complications such as fever, infection and sepsis (see section 4.8).
Kot je bilo pričakovati, se bolniki v slabšem telesnem stanju (PS > 1) slabše odzivajo na zdravilo in pri njih tudi pogosteje opažamo zaplete, kot so zvišana telesna temperatura, okužbe in sepsa (glejte poglavje 4.8).
As expected, patients with poor performance status (PS > 1) have a lower response rate and an increased incidence of complications such as fever, infection and sepsis (see section 4.8).
Po pričakovanju je med bolniki s slabim stanjem zmogljivosti (stanje zmogljivosti > 1) delež odziva manjši; hkrati imajo večjo incidenco zapletov, kot so zvišana telesna temperatura, okužbe in sepsa (glejte poglavje 4.8).
As expected, patients with poor performance status (PS>1) have a lower response rate and an increased incidence of complications such as fever, infection and sepsis (see section 4.8).
Kakor bi pričakovali, se bolniki v slabem telesnem stanju (PS > 1) slabše odzivajo na zdravilo in imajo večjo incidenco zapletov, kot so zvišana telesna temperatura, okužbe in sepsa (glejte poglavje 4.8).
As expected, patients with poor performance status (PS>1) have a lower response rate and an increased incidence of complications such as fever, infection and sepsis (see section 4.8).
Kot je bilo pričakovati, se bolniki v slabšem telesnem stanju (PS>1) slabše odzivajo na zdravilo in pri njih tudi pogosteje opažamo zaplete, kot so zvišana telesna temperatura, okužbe in sepsa (glejte poglavje 4.8).
As explained in 'Warnings and precautions’, above, your doctor will monitor you with liver tests or for undesirable effects such as rash.
Kot je opisano v poglavju ”Opozorila in previdnostni ukrepi”, bo zdravnik vaše ali otrokovo stanje spremljal s preiskavami delovanja jeter in da bi odkril neželene učinke, kot je izpuščaj.
As explained in ‘Warnings and precautions’, above, your doctor will monitor you with liver tests or for undesirable effects such as rash.
Kot je opisano v poglavju "Opozorila in previdnostni ukrepi", bo zdravnik vaše stanje spremljal s preiskavami delovanja jeter ali za pojav neželenih učinkov, kot je izpuščaj.
As explained in ‘Warnings and precautions’, above, your doctor will monitor you with liver tests or for undesirable effects such as rash.
Kot je opisano v poglavju ”Opozorila in previdnostni ukrepi”, bo zdravnik vaše stanje spremljal s preiskavami delovanja jeter ali za pojav neželenih učinkov, kot je izpuščaj.
As explained in ‘Warnings and precautions’, above, your doctor will monitor you with liver tests or for undesirable effects such as rash.
Kot je opisano v poglavju ”Opozorila in previdnostni ukrepi”, bo zdravnik vaše stanje spremljal s preiskavami delovanja jeter in da bi odkril neželene učinke, kot je izpuščaj.
As exposure may be increased in HCV infected patients with severe renal impairment, caution is recommended when prescribing simeprevir to these patients (see section 4.2).
≥ 80 ml/min), Ker se lahko pri bolnikih z okužbo s HCV in hudo okvaro ledvic izpostavljenost poveča, je pri predpisovanju simeprevirja tem bolnikom potrebna previdnost.
As Eylea is a protein-based therapeutic, no metabolism studies have been conducted.
Ker je zdravilo Eylea terapevtski protein, študij presnove niso izvedli.
As for all parenteral products, ampoules of Pedea should be visually inspected for particulate matter and the integrity of the container prior to use.
Kot vse parenteralne pripravke je zdravilo Pedea potrebno pregledati glede prisotnosti delcev in integritete embalaže.
As for all patients, depending on individual patient response, a dose adjustment may be considered (see section 4.2).
Glede na odziv posameznega bolnika je potrebno, kot za vse bolnike, razmisliti o prilagoditvi odmerka (glejte poglavje 4.2).
As for all preterm infants, those treated with caffeine citrate should be carefully monitored for the development of necrotising enterocolitis (see section 4.4).
Kot pri vseh nedonošenčkih je treba tudi pri tistih, zdravljenih s kofeinijevim citratom, skrbno nadzirati razvoj nekrotizirajočega enterokolitisa (glejte poglavje 4.4).
As for all vaccines, if Infanrix hexa is used in babies born very prematurely, there is a risk of them experiencing apnoea (brief pauses in breathing).
Tako kot pri vseh cepivih obstaja tudi pri cepivu Infanrix hexa tveganje za razvoj apneje (kratkih premorov pri dihanju), če se daje mnogo prezgodaj rojenim dojenčkom.
As for any combination of two active substances, side effects associated with each individual component cannot be excluded.
Kot pri uporabi katerekoli kombinacije dveh zdravilnih učinkovin, ni mogoče izključiti možnosti neželenih učinkov, ki so povezani s posameznimi zdravilnimi učinkovinami.
As for any immune modulating medicinal product, before initiating a course of LEMTRADA treatment, patients without a history of chickenpox or without vaccination against varicella zoster virus (VZV) should be tested for antibodies to VZV.
Kot pri vsakem zdravilu, ki spremeni imunski odziv, je treba pred zdravljenjem z zdravilom LEMTRADA bolnikom brez noric ali cepljenja proti virusu varicella zoster v anamnezi določiti raven protiteles proti temu virusu.
As for any long term NSAID treatment, renal function should be monitored.
Kot pri vsakem dolgotrajnem zdravljenju z NSAID, je treba spremljati delovanje ledvic.
As for any medicine that acts directly on the RAAS, aliskiren should not be used during the first trimester of pregnancy and is contraindicated during the second and third trimesters (see section 4.3).
Tako kot velja za katerokoli drugo zdravilo, ki deluje neposredno na sistem renin-angiotenzin-aldosteron, tudi aliskirena ne smete uporabljati v prvem trimesečju nosečnosti, kontraindiciran pa je tudi v drugem in tretjem trimesečju nosečnosti (glejte poglavje 4.3).
As for any medicine that acts directly on the RAAS, Rasilez should not be used during the first trimester of pregnancy or in women planning to become pregnant and is contraindicated during the second and third trimesters (see section 4.3).
Tako kot velja za katerokoli drugo zdravilo, ki deluje neposredno na sistem renin-angiotenzin-aldosteron, tudi zdravila Rasilez ne smete uporabljati v prvem trimesečju nosečnosti oziroma pri ženskah, ki načrtujejo nosečnost, poleg tega je kontraindiciran v drugem in tretjem trimesečju nosečnosti (glejte poglavje 4.3).
As for any other antineoplastic agent, caution should be exercised when handling and preparing JEVTANA solutions, taking into account the use of containment devices, personal protective equipment (e.g. gloves), and preparation procedures.
Tako kot velja za druga zdravila proti raku, je tudi pri pripravi raztopin zdravila JEVTANA in ravnanju z njimi potrebna previdnost; uporabiti je treba naprave za prestrezanje, osebno zaščitno opremo (npr. rokavice) in upoštevati je treba postopke priprave.
As for its risks, the side effects of Oncaspar are similar to those of other asparaginase medicines and are manageable.
Kar se tiče tveganj, so neželeni učinki zdravila Oncaspar podobni kot pri drugih zdravilih z asparaginazo in so obvladljivi.
As for its risks, the side effects of Spectrila are similar to those of other asparaginase medicines and are addressed in the medicine’s risk minimisation plan.
Kar se tiče tveganj, so neželeni učinki zdravila Spectrila podobni kot pri drugih zdravilih z asparaginazo in so obravnavani v načrtu za zmanjševanje tveganja za to zdravilo.
As for other agents acting on the renin-angiotensin system, caution should be exercised when aliskiren is given in the presence of conditions pre-disposing to kidney dysfunction such as hypovolaemia (eg. due to blood loss, severe prolonged diarrhoea, prolonged vomiting, etc.), heart disease, liver disease or kidney disease.
Kot pri uporabi drugih zdravil, ki delujejo na sistem renin-angiotenzin, je potreba previdnost pri uporabi aliskirena pri bolnikih z drugimi boleznimi, zaradi katerih so bolj nagnjeni k slabšemu delovanju ledvic, kot so hipovolemija (na primer zaradi izgube krvi, hude ali dolgotrajne diareje, dolgotrajnega bruhanja in podobno), bolezni srca, jeter ali ledvic.
As for other agents acting on the renin-angiotensin system, caution should be exercised when aliskiren is given in the presence of conditions pre-disposing to kidney dysfunction such as hypovolaemia (eg. due to blood loss, severe prolonged diarrhoea, prolonged vomiting, etc.), heart disease, liver disease, diabetes mellitus or kidney disease.
Kot pri uporabi drugih zdravil, ki delujejo na sistem renin-angiotenzin, je potreba previdnost pri uporabi aliskirena pri bolnikih z drugimi boleznimi, zaradi katerih so bolj nagnjeni k slabšemu delovanju ledvic, kot so hipovolemija (na primer zaradi izgube krvi, hude ali dolgotrajne diareje, dolgotrajnega bruhanja in podobno), bolezni srca, jeter, sladkorna bolezen ali bolezen ledvic.
As for other insulin products, in general, hypoglycaemia is the most frequently occurring undesirable effect.
Tako kot pri drugih insulinih je praviloma najpogostejši neželeni ucinek hipoglikemija.
As for other medicinal products acting on the renin-angiotensin system, caution should be exercised when aliskiren is given in the presence of conditions pre-disposing to kidney dysfunction such as hypovolaemia (e.g. due to blood loss, severe or prolonged diarrhoea, prolonged vomiting, etc.), heart disease, liver disease, diabetes mellitus or kidney disease.
Kot pri uporabi drugih zdravil, ki delujejo na sistem renin-angiotenzin, je potreba previdnost pri uporabi aliskirena pri bolnikih z drugimi boleznimi, zaradi katerih so bolj nagnjeni k slabšemu delovanju ledvic, kot so hipovolemija (na primer zaradi izgube krvi, hude ali dolgotrajne diareje, dolgotrajnega bruhanja in podobno), bolezni srca, jeter, sladkorna bolezen ali bolezen ledvic.
As for other medicinal products acting on the renin-angiotensin system, caution should be exercised when aliskiren is given in the presence of conditions pre-disposing to kidney dysfunction such as hypovolaemia (eg. due to blood loss, severe prolonged diarrhoea, prolonged vomiting, etc.), heart disease, liver disease, diabetes mellitus or kidney disease.
Kot pri uporabi drugih zdravil, ki delujejo na sistem renin-angiotenzin, je potreba previdnost pri uporabi aliskirena pri bolnikih z drugimi boleznimi, zaradi katerih so bolj nagnjeni k slabšemu delovanju ledvic, kot so hipovolemija (na primer zaradi izgube krvi, hude ali dolgotrajne diareje, dolgotrajnega bruhanja in podobno), bolezni srca, jeter, sladkorna bolezen ali bolezen ledvic.
As for other quinolones, due to possible adverse effects on the articular cartilage of weight bearing joints difloxacin should not be used during the rapid growth phase, that is, do not use in small and medium-sized breeds of dogs up to and including 8 months of age, in large breeds up to 1 year of age and in giant breeds up to 18 months of age.
Tako kot drugi fluorokinoloni tudi difloksacin učinkuje zaviralno na rast in obnavljanje sklepnega hrustanca, zato ga ne uporabite pri psih v fazi hitre rasti, ki je pri majhnih in srednje velikih pasmah psov do 8. meseca starosti, pri večjih pasmah do 1 leta, pri izredno velikih pasmah psov pa do 18. meseca starosti.
As for other RAAS blockers, headache is a common adverse event in children treated with aliskiren.
Tako kot pri uporabi drugih učinkovin, ki zavirajo sistem renin-angiotenzin- aldosteron, je pri zdravljenju otrok z aliskirenom glavobol pogost neželeni dogodek.
As for plasma-derived C1INH, the pharmacodynamic effects of conestat alfa on C4 show dose-dependent restoration of complement homeostasis in HAE patients at a plasma C1INH activity level greater than 0.7 U/ml, which is the lower limit of the normal range.
Glede iz plazme pridobljenega C1INH farmakodinamični učinki konestata alfa na C4 kažejo od odmerka odvisno ponovno vzpostavitev homeostaze komplementa pri bolnikih s HAE pri ravni aktivnosti C1INH v plazmi, večji od 0,7 e/ml, ki je spodnja meja normalne vrednosti.