natgillin/translations-raw huggingface dataset:
Therefore, when switching between fentanyl containing medicinal products indicated for treatment of breakthrough pain, including intranasal formulations, it is essential that patients are again titrated with the new medicinal product, and not switched on a dose-for-dose (microgram-formicrogram) basis. 
Zato je pri prehajanju z enega zdravila, ki vsebuje fentanil s takojšnjim sproščanjem in je indicirano za zdravljenje prebijajoče bolečine, vključno z zdravili za intranazalno uporabo, na drugo tako zdravilo bistveno, da bolnike ponovno titriramo z novim zdravilom, namesto da bi prešli z enega zdravila na drugega na podlagi enakega odmerka v mikrogramih.
[2 spray bottle:] 1 bottle - 0.95 ml (2 sprays) per bottle 
[Steklenica z 2 vpihoma:] 1 steklenica - 0,95 ml (2 vpiha) na steklenico
Relative bioavailability of fentanyl from the PecFent treatment compared to the 200 microgram OTFC was approximately 
Relativna biološka uporabnost fentanila iz zdravila PecFent v primerjavi z 200 mikrogrami OTFC je bila približno 120 %.
There are still doses of PecFent left in the bottle. 
V steklenici so še ostali odmerki zdravila PecFent.
The patient should be advised to write the date of first use in the space provided on the label of the child resistant container. 
Bolniku svetujte, naj zapiše datum prve uporabe zdravila na temu namenjeno mesto na etiketi vsebnika z zaporko, varno za otroke.
• The starting dose is 100 micrograms. 
Začetni odmerek • Začetni odmerek je 100 mikrogramov.
Wipe the nozzle with a tissue and flush the tissue down the toilet. 
Obrišite razpršilno šobo s papirnatim robčkom in ga vrzite v straniščno školjko.
Firmly press down on the finger grips so that PecFent sprays into your nostril. 
Čvrsto pritisnite na sprožilec, tako da bo črpalka oddala odmerek v vašo nosnico.
In the randomised, placebo-controlled study (CP043) 9.4% of 459 PecFent-treated BTP episodes in 73 patients required use of any further (rescue) medicinal products within 60 minutes of dosing. 
V randomizirani, s placebom kontrolirani študiji (CP043) je bila pri 9,4 % od 459 epizod BTP, zdravljenih z zdravilom PecFent, pri 73 bolnikih potrebna uporaba kakih drugih (rešilnih) zdravil v
Each bottle contains 1.55 ml (6,200 micrograms fentanyl) 
Ena steklenica vsebuje 1,55 ml (6.200 mikrogramov fentanila).
The mean pain intensity scores (73 patients) for all PecFent-treated episodes (459 episodes) compared to those treated with placebo (200 episodes) were significantly lower at 5, 10, 15, 30, 45 and 60 minutes following administration (see Figure 1). 
PecFent (459 epizod), v primerjavi z epizodami, zdravljenimi s placebom (200 epizod), so bili značilno manjši po 5, 10, 15, 30, 45 in 60 minutah od uporabe (glejte sliko 1).
If you use more PecFent than you should 
Če ste uporabili večji odmerek zdravila PecFent, kot bi smeli
• muscle convulsions or trembling 
• mišični krči ali drgetanje,
• The initial dose of PecFent to treat episodes of BTP is always 100 micrograms (one spray), even in patients switching from other fentanyl containing products for their BTP. 
Začetni odmerek • Začetni odmerek zdravila PecFent za zdravljenje epizod BTP je vedno 100 mikrogramov (en vpih), tudi pri bolnikih, ki preidejo z drugih zdravil, ki vsebujejo fentanil, zaradi zdravljenja BTP.
In the PecFent clinical trial programme, 104 (26.1%) of patients were over 60 years of age, 67 (16.8%) over 65 years and 15 (3.8%) over 75 years. 
bolnikov (16,8 %) je bilo starejših od 65 let in 15 (3,8 %) starejših od 75 let.
• Only use PecFent nasal spray if you have received the proper information regarding the use of the device and the safety precautions from the prescriber and/or the pharmacist 
• pršilo za nos PecFent uporabljajte le, če ste od zdravnika, ki vam je predpisal zdravilo, in/ali od farmacevta prejeli natančne informacije o uporabi pripomočka in varnostnih ukrepih;
0.95 ml ensuring delivery of 2 full sprays or 
0,95 ml, kar zagotavlja 2 polna vpiha ali
What you need to know before you use PecFent Do not use PecFent if: 
Kaj morate vedeti, preden boste uporabili zdravilo PecFent Ne uporabljajte zdravila PecFent:
Any empty bottles should be returned to their child resistant container and discarded by taking them back to the pharmacy or according to local requirements. 
Prazne steklenice shranite v vsebniku z zaporko, varno za otroke, in jih odvrzite, tako da jih vrnete v lekarno, ali v skladu z lokalnimi zahtevami.
• cough, sneezing, catarrh or cold, changes in the fluid produced by your nose 
• kašelj, kihanje, nahod ali prehlad, spremembe tekočine, ki nastaja v nosu,
• Instructions for opening and closing of the child-resistant box 
• navodila za odpiranje in zapiranje vsebnika, varnega za otroke;
2 spray bottle: 
Steklenica z 2 vpihoma:
It is advised not to use fentanyl during labour and delivery (including caesarean section) because fentanyl passes through the placenta and may cause respiratory depression in the foetus. 
Uporabo fentanila med popadki in porodom (vključno s carskim rezom) odsvetujemo, ker fentanil prehaja skozi posteljico in lahko povzroči depresijo dihanja pri plodu.
1.55 ml ensuring delivery of 8 full sprays. 
1,55 ml, kar zagotavlja 8 polnih vpihov.
PecFent contains fentanyl, which is a strong pain-relieving medicine known as an opioid pain killer. 
Zdravilo PecFent vsebuje fentanil, ki je močno protibolečinsko zdravilo, znano kot opioidni analgetik.
A clear to practically clear colourless aqueous solution. 
Bistra do skoraj bistra brezbarvna vodna raztopina.
What PecFent is and what it is used for What you need to know before you use PecFent How to use PecFent 
Kaj je zdravilo PecFent in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo PecFent Kako uporabljati zdravilo PecFent
However, you should keep taking your other opioid medicine to treat your constant pain. 
Vaše drugo opioidno zdravilo za blaženje vaše stalne bolečine pa morate uporabljati še naprej.
Dose-proportionality was demonstrated for Cmax and area under the curve (AUC) in the dose range 100 micrograms to 800 micrograms (see Figure 3). 
Sorazmernost odmerkom so dokazali za Cmax in površino pod krivuljo (AUC) v mejah odmerkov 100 mikrogramov do 800 mikrogramov (glejte sliko 3).
The SPID for PecFent-treated episodes was also significantly different to placebo at 10 15, 45 and 60 minutes after administration. 
se je tudi značilno razlikoval od placeba 10, 15, 45 in 60 minut po uporabi.
Not all presentations or pack sizes may be marketed. 
Na trgu morda ni vseh navedenihoblik ali pakiranj.
Patients should be advised not to blow their nose immediately after PecFent administration. 
Bolnikom morate svetovati, naj se ne usekujejo takoj po uporabi zdravila PecFent.
• Put the protective cap back on the spray bottle. 
• Namestite zaščitno zaporko nazaj na steklenico s pršilom.
Dehydration Hyperglycaemia Decreased appetite Increased appetite 
Presnovne in prehranske motnje dehidracija hiperglikemija zmanjšan apetit zvečan apetit
Therefore, special care should be taken during the titration process in patients with moderate or severe hepatic or renal impairment. 
Zato je pri postopku titracije pri bolnikih z zmernimi ali težkimi okvarami jeter ali ledvic potrebna posebna skrbnost.
Put the nozzle a short distance (about 1 cm) into your nostril. 
Vtaknite razpršilno šobo nekoliko (okrog 1 cm) v nosnico.
Preparing the PecFent bottle for use 
Priprava steklenice zdravila PecFent za uporabo
In particular tell your doctor or pharmacist before using PecFent if you are taking or have recently taken any of the following medicines: 
Preden uporabite zdravilo PecFent, svojega zdravnika ali farmacevta še zlasti obvestite, če uporabljate ali ste pred nedavnim uporabljali katero od naslednjih zdravil:
• You will need to press down and release the finger grips 4 more times while aiming the nasal spray away from you (and any other people). 
• Še štirikrat pritisnite in spustite sprožilec in pri tem usmerite pršilo za nos proč od sebe (in drugih ljudi).
The PecSys system allows the product to be sprayed into the front area of the nasal cavity as a fine mist of droplets, which gel on contact with the calcium ions present in the nasal mucosa. 
Sistem PecSys omogoča razpršitev zdravila v sprednji del nosne votline v obliki pršca drobnih kapljic, ki se v stiku s kalcijevimi ioni, ki so prisotni v nosni sluznici, spremenijo v gel.
PecFent maintenance treatment may also be less effective in patients with rhinitis when administered concomitantly with a nasal vasoconstrictive decongestant. 
Vzdrževalno zdravljenje z zdravilom PecFent je lahko manj učinkovito tudi pri bolnikih z rinitisom (nahodom), če ga dajemo sočasno s kakim nazalnim vazokonstriktivnim dekongestivom.
• See ‘Using the PecFent bottle' for instructions on how to use a dose. 
• Za navodila o uporabi odmerka glejte ‘Kako uporabljajte steklenico zdravila PecFent'.
A pharmacokinetic study was conducted to evaluate the absorption and tolerability of a single dose of PecFent in patients with pollen-induced seasonal allergic rhinitis, comparing the un-challenged, acutely challenged (rhinitic) and acutely challenged and then treated with oxymetazoline, states. 
Opravili so farmakokinetično študijo, v kateri so ocenjevali absorpcijo in prenašanje enkratnega odmerka zdravila PecFent pri bolnikih s sezonskim alergijskim rinitisom, ki ga povzroča pelod, pri čemer so primerjali neprovocirano stanje, akutno izzvano (rinitično) stanje in akutno provocirano stanje, ki je bilo nato zdravljeno z oksimetazolinom.
The treatment for persistent backgound pain should be kept as prescribed. 
Zdravljenje dolgotrajne osnovne bolečine naj ostane, kakršno je.
• When you see the red 2 in the counting window, the bottle is finished and you will no longer be able to get a full spray from it. 
• Ko boste v okencu števca videli rdeče število 2, je steklenica porabljena in iz nje ne boste več mogli dobiti polnega vpiha.
• you experience a combination of the following symptoms: nausea, vomiting, anorexia, fatigue, weakness, dizziness and low blood pressure. 
• imate kombinacijo naslednjih simptomov: navzea (občutek siljenja na bruhanje), bruhanje, anoreksija (izguba teka), utrujenost, šibkost, omotica in znižan krvni tlak.
• convulsion (fits) 
• konvulzije (epileptični napadi),
If the patient experiences recurrent episodes of epistaxis or nasal discomfort while taking PecFent, an alternative method of administration for treatment of breakthrough pain should be considered. 
Če ima bolnik med uporabo zdravila PecFent recidivirajoče epizode epistakse ali bolečin v nosu, je treba pretehtati alternativen način uporabe za zdravljenje prebijajoče bolečine.
A double-blind, randomised, placebo-controlled crossover study has been conducted in which 114 patients who experienced on average 1 to 4 episodes of break through pain (BTP) per day while taking maintenance opioid therapy were entered into an initial open-label titration phase in order to identify an effective dose of PecFent (Study CP043). 
114 bolnikov, ki so imeli med vzdrževalnim opioidnim zdravljenjem povprečno po 1 do 4 epizode prebijajoče bolečine (BTP) na dan, vključili v začetno odprto fazo titracije, da bi ugotovili učinkoviti odmerek zdravila PecFent (študija CP043).
For treatment of overdose (accidental ingestion) in the opioid-naïve person, intravenous access should be obtained and naloxone or other opioid antagonists should be employed as clinically indicated. 
Za zdravljenje prevelikega odmerka (naključnega zaužitja) pri osebi, ki še ni prejemala opioidov, je treba pripraviti intravenski kanal in glede na klinično indikacijo uporabiti nalokson ali druge opioidne antagoniste.
Titration in patients switching between immediate-release fentanyl containing products Substantial differences may exist in the pharmacokinetic profile of immediate-release fentanyl medicinal products, which result in clinically important differences in the rate and extent of absorption of fentanyl. 
V farmakokinetičnem profilu zdravil s takojšnjim sproščanjem fentanila so lahko precejšnje razlike, kar povzroča klinično pomembne razlike v hitrosti in obsegu absorpcije fentanila.
• numbness or tingling in the mouth, tongue, or nose, or other tongue problems, mouth ulcers, dry mouth 
• odrevenelost ali mravljinčenje v ustih, jeziku ali nosu ali druge težave z jezikom, razjede v ustih, suha usta,
There are 8 full sprays in each PecFent bottle. 
V vsaki steklenici zdravila PecFent je 8 polnih vpihov.
• The prescriber must make use of the checklist for prescribers 
• Zdravnik, ki predpisuje zdravilo, mora uporabljati kontrolni seznam za zdravnike, ki predpisujejo zdravilo.
The free fraction of fentanyl increases with acidosis. 
Prosta frakcija fentanila se zveča z acidozo.
Educational material for patients should highlight the following: 
Izobraževalno gradivo za bolnike naj poudari naslednje:
0.95 ml - 2 sprays 1.55 ml - 8 sprays 
0,95 ml - 2 vpiha 1,55 ml - 8 vpihov
• allergic reaction, rash 
• alergijska reakcija, izpuščaj,
PecFent is indicated for the management of breakthrough pain (BTP) in adults who are already receiving maintenance opioid therapy for chronic cancer pain. 
Zdravilo PecFent je indicirano za obvladovanje prebijajoče bolečine (BTP - breakthrough pain) pri odraslih, ki že prejemajo vzdrževalno opioidno terapijo za kronično bolečino zaradi raka.
If you are not going to use your medicine straight away, put the protective cap back on. Then put the PecFent bottle in the child-resistant storage container. 
Če zdravila ne boste uporabili takoj, namestite zaščitno zaporko nazaj na razpršilno šobo.
Tell your doctor or pharmacist if you have taken an MAOI medicine in the past 2 weeks before using PecFent. 
Povejte svojemu zdravniku ali farmacevtu, če ste zadnja 2 tedna, preden ste začeli uporabljati zdravilo
Fentanyl passes into breast milk and may cause sedation and respiratory depression in the breast-fed child. Fentanyl should not be used by breastfeeding women and breast-feeding should not be restarted until at least 5 days after the last administration of fentanyl. 
Ženske, ki dojijo, fentanila ne smejo uporabljati, z dojenjem pa ne smejo spet začeti prej kot vsaj 5 dni po zadnji uporabi fentanila.
o other pain killers called partial agonist/antagonist like buprenorphine, nalbuphine, pentazocine. 
o druga zdravila proti bolečinam, ki se imenujejo delni agonisti/antagonisti, na primer buprenorfin, nalbufin, pentazocin.
• When you see a red 8 in the counting window, the bottle is finished and you will no longer be able to get a full spray from it. 
• Ko boste v okencu števca videli rdeče število 8, je steklenica porabljena in iz nje ne boste več mogli dobiti polnega vpiha.
• If you have any further questions, ask your doctoror pharmacist. 
• Če imate dodatna vprašanja, se posvetujte z zdravnikom ali farmacevtom.
0.95 ml (950 micrograms fentanyl) - 2 spray bottle or 
0,95 ml (950 mikrogramov fentanila) - steklenica z 2 vpihoma ali
Educational material for pharmacists should highlight the following: 
Izobraževalno gradivo za farmacevte naj poudari naslednje:
If you can see a number, other than 8 in the counting window, you have NOT used all 8 sprays in the bottle. 
Če v okencu s števcem vidite število, ki ni 8, še NISTE porabili vseh 8 vpihov v steklenici.
Chronic pulmonary disease 
Kronične bolezni pljuč
This will go up to the number 2 when the spray is used again. 
Ob ponovni uporabi pršila se bo povečalo na 2.
To administer PecFent the nozzle is placed a short distance (about 1 cm) into the nostril and pointed slightly towards the bridge of the nose. 
Bolnik uporabi zdravilo PecFent tako, da namesti razpršilno šobo nekoliko (okrog 1 cm) v nosnico in jo usmeri nekoliko proti nosnemu hrbtišču.
Following treatment of the acute rhinitic state with oxymetazoline, there were reductions in Cmax and exposure, and increases in Tmax that were statistically, and possibly clinically, significant. 
Po zdravljenju akutnega rinitičnega stanja z oksimetazolinom sta se Cmax in izpostavljenost zmanjšali, Tmax pa zvečal.
If you are not sure, talk to your doctor or pharmacist before using PecFent. 
Če ste negotovi, se posvetujte z zdravnikom ali farmacevtom, preden uporabite zdravilo PecFent.
When you see the number “2” in the counting window, there is still medicine in the bottle that you must empty. 
Ko v okencu s števcem vidite število “2”, je v steklenici še nekaj zdravila, ki ga morate izprazniti.
• Only use PecFent nasal spray if you are using other opioid pain medicine on a daily basis 
• pršilo za nos PecFent uporabljajte le, če vsak dan uporabljate kako drugo opioidno sredstvo proti bolečinam;
The PecFent spray droplets form a gel in the nose. 
Kapljice pršila PecFent v nosu oblikujejo gel.
• Patients must wait at least 4 hours before treating another episode of BTP with PecFent. 
• Bolniki morajo počakati vsaj 4 ure po odmerku, preden vzamejo nov odmerek zdravila PecFent za zdravljenje naslednje epizode BTP.
EU/1/10/644/007 100 micrograms, 2 sprays, 1 bottle EU/1/10/644/001 100 micrograms, 8 sprays, 1 bottle EU/1/10/644/002 100 micrograms, 8 sprays, 4 bottles EU/1/10/644/005 100 micrograms, 8 sprays, 12 bottles 
EU/1/10/644/007 100 mikrogramov, 2 vpiha, 1 steklenica EU/1/10/644/001100 mikrogramov, 8 vpihov, 1 steklenica EU/1/10/644/002100 mikrogramov, 8 vpihov, 4 steklenice EU/1/10/644/005100 mikrogramov, 8 vpihov, 12 steklenic
Figure 3: Mean plasma fentanyl concentrations following single doses of PecFent and OTFC in healthy subjects 
Slika 3: Povprečne koncentracije fentanila v plazmi po enkratnih odmerkih zdravila PecFent in OTFC
PecFent could be life-threatening if taken by a child by accident. 
Zdravilo PecFent bi namreč lahko bilo smrtno nevarno, če bi ga po nesreči uporabil otrok.
Hold the PecFent bottle with your thumb on the bottom of the bottle and your first and middle fingers on the finger grips (Figure 4). 
Držite steklenico zdravila PecFent s palcem na dnu steklenice in kazalcem in sredincem na sprožilec (slika 4).
However, the most serious adverse reactions are respiratory depression (potentially leading to apnoea or respiratory arrest), circulatory depression, hypotension and shock and all patients should be monitored for these. 
Najresnejši neželeni učinki so depresija dihanja (ki lahko pripelje do apneje ali zastoja dihanja), depresija krvnega obtoka, hipotenzija in šok.
8 spray bottle: If the product has not been used for 5 days, it should be re-primed by spraying once. 
Steklenica z 8 vpihi: Če bolnik ni uporabljal zdravila 5 dni, ga je treba reaktivirati z enim pritiskom na sprožilec.
When you see the number “8” in the counting window, there is still medicine in the bottle that you must empty. 
Ko v okencu s števcem vidite število “8”, je v steklenici še nekaj zdravila, ki ga morate izprazniti.
• You must keep PecFent in the child resistant storage container when you are not using it, even if you have used all 8 sprays. 
• Zdravilo PecFent morate shranjevati v vsebniku z zaporko, varno za otroke, kadar ga ne uporabljate, tudi če ste že porabili vseh 8 vpihov.
When you hear a click let go of the grips. 
Ko zaslišite klik, sprožilec spustite.
• PecFent nasal spray should be prescribed only by physicians experienced in the management of opioid therapy in cancer patients. 
• Pršilo za nos PecFent smejo predpisovati samo zdravniki, ki imajo izkušnje z vodenjem opioidnega zdravljenja pri bolnikih z rakom.
The primary endpoint was the comparison between the summed pain intensity difference at 30 minutes after dosing (SPID30), which was 6.57 in the PecFent-treated episodes compared to 4.45 for placebo (p<0.0001 ). 
(summed pain intensity difference - SPID30), ki je bila 6,57 v epizodah, zdravljenih z zdravilom PecFent, v primerjavi s 4,45 pri placebu (p<0,0001 ).
Fentanyl is highly lipophilic and can be absorbed very rapidly through the nasal mucosa and more slowly by the gastrointestinal route. 
Fentanil je zelo lipofilen in se lahko zelo hitro absorbira skozi nosno sluznico, nekoliko počasneje pa skozi prebavila.
• You must keep PecFent in the child resistant storage container when you are not using it, even if you have used all 2 sprays. 
• Zdravilo PecFent morate shranjevati v vsebniku z zaporko, varno za otroke, kadar ga ne uporabljate, tudi če ste že porabili vseh 2 vpihov.
• you suffer from short-term pain other than breakthrough pain. 
• če imate drugo kratkotrajno bolečino, ki ni prebijajoča bolečina;
Fentanyl is metabolised in the liver to norfentanyl by cytochrome CYP3A4 isoform. 
Fentanil presnavlja izooblika citokroma CYP3A4 v jetrih v norfentanil.
Disposition of fentanyl following intranasal administration of PecFent has not been characterised in a mass balance study. 
Odstranjevanja fentanila iz telesa po intranazalni uporabi zdravila PecFent niso podrobno proučili v nobeni študiji masnega ravnovesja.
Any unwanted PecFent should be disposed of as soon as possible following the instructions under Disposal of unused PecFent. 
Zdravilo PecFent, ki ga ne potrebujete več, čim prej odvrzite v skladu z navodili pod naslovom Kako zavržete neporabljeno zdravilo PecFent.
Caution is advised when PecFent is coadministered with medicinal products that affect the serotoninergic neurotransmitter systems. 
Pri sočasni uporabi zdravila PecFent z zdravili, ki vplivajo na sistem serotoninergičnih nevrotransmiterjev, je potrebna previdnost.
Excipients with known effect: Each spray contains 0.02 mg propylparahydroxybenzoate (E216). 
Pomožne snovi z znanim učinkom: En vpih vsebuje 0,02 mg propilparahidroksibenzoata (E216).
• Tell your doctor straight away if you have more than 4 episodes of breakthrough pain a day. 
• Takoj povejte zdravniku, če imate več kot 4 epizode prebijajoče bolečine na dan. Mogoče bo zdravnik spremenil zdravilo za vašo stalno bolečino.
MANUFACTURERRESPONSIBLE FOR BATCH RELEASE 
IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJ
Educational material for physicians should highlight the following: 
Izobraževalno gradivo za zdravnike naj poudari naslednje:
Discontinuation of therapy 
Ukinitev zdravljenja
EU/1/10/644/003 400 micrograms, 8 sprays, 1 bottle EU/1/10/644/004 400 micrograms, 8 sprays, 4 bottles EU/1/10/644/006 400 micrograms, 8 sprays, 12 bottles 
EU/1/10/644/003400 mikrogramov, 8 vpihov, 1 steklenica EU/1/10/644/004400 mikrogramov, 8 vpihov, 4 steklenice EU/1/10/644/006400 mikrogramov, 8 vpihov, 12 steklenic
EU/1/10/644/001 EU/1/10/644/002 EU/1/10/644/005 
EU/1/10/644/007 EU/1/10/644/001 EU/1/10/644/002 EU/1/10/644/005
1.55 ml - 8 sprays 
1,55 ml - 8 vpihov
PecFent is available in two strengths: 100 micrograms/spray and 400 micrograms/spray. 
Zdravilo PecFent je na voljo v dveh jakostih: 100 mikrogramov/vpih in 400 mikrogramov/vpih.
Using PecFent PecFent is only to be used by spraying into your nostril. 
Uporaba zdravila PecFent Zdravilo PecFent smete uporabljati samo tako, da si ga pršite v nosnico.
Hydrochloric acid (0.36%) or sodium hydroxide (for pH adjustment) Purified water 
saharozo, prečiščeno vodo in klorovodikovo kislino (0,36 %) ali natrijev hidroksid za uravnavanje pH.
PecFent 2 spray bottles in their child resistant containers are supplied in a carton containing 1 bottle. 
Steklenice zdravila PecFentz 2 vpihoma v vsebnikih z zaporko, varno za otroke, se dobavljajo v škatlah z 1 steklenico.
Pharmacokinetic parameters in adult subjects receiving PecFent and OTFC 
Farmakokinetični parametri pri odraslih osebah, ki so uporabljale zdravilo PecFent in OTFC Farmakokinetični parametri
• You should not start breast-feeding within 5 days after the last dose of PecFent. 
• Preden začnete dojiti, morate počakati 5 dni od zadnjega odmerka zdravila PecFent.
• Only use PecFent nasal spray if you have been experiencing breakthrough cancer pain episodes 
• pršilo za nos PecFent uporabljajte le, če doživljate epizode prebijajoče bolečine zaradi raka;
What PecFent looks like and contents of the pack 
Izgled zdravila PecFent in vsebina pakiranja
There is a risk of clinically significant respiratory depression associated with the use of fentanyl. 
Z uporabo fentanila je povezano tveganje klinično pomembne depresije dihanja.