natgillin/translations-raw huggingface dataset:
Most minor reactions to insulins at the injection site usually resolve in a few days to a few weeks. 
Večina blažjih reakcij na insuline na mestu injiciranja po navadi mine v nekaj dneh do nekaj tednih.
Pharmacokinetic profiles were consistent with the pharmacodynamic activity of Toujeo. 
Farmakokinetične značilnosti so se skladale s farmakodinamično aktivnostjo zdravila Toujeo.
B Press the injection button all the way in. 
B Pritisnite gumb za injiciranje do konca noter.
• Lithium salts - for mental health problems. 
• Litijeve soli - za težave z duševnim zdravjem.
• Never use your pen after the expiration date. 
• Peresnika nikdar ne uporabljajte po datumu izteka roka uporabnosti.
Toujeo pre-filled pens have to be used as recommended in these Instructions for Use (see section 4.2). 
Napolnjene injekcijske peresnike Toujeo je treba uporabljati, kot je priporočeno v teh navodilih za uporabo (glejte poglavje 4.2).
For insulin glargine no clinical data on exposed pregnancies from controlled clinical studies are available. 
Za insulin glargin iz kontroliranih kliničnih študij ni kliničnih podatkov o izpostavljenih nosečnicah.
Steady state level within the therapeutic range is reached after 3-4 days of daily Toujeo administration. 
Stanje dinamičnega ravnovesja je v terapevtskem območju doseženo po 3 do 4 dneh uporabe zdravila Toujeo.
Used needles should be thrown away in a puncture resistant container or disposed of in accordance with local requirements. 
Uporabljene igle je treba vreči v posodo za odlaganje ostrih odpadkov ali odstraniti v skladu z lokalnimi predpisi.
This could cause high blood sugar. 
Posledica je lahko visok krvni sladkor.
Flexibility in dosing time 
Prilagodljivost časa uporabe
Switching from the 300 units/ml to the 100 units/ml concentration results in an increased risk of hypoglycaemic events, mainly in the first week after the switch. 
Prehod z jakosti 300 enot/ml na 100 enot/ml poveča tveganje za hipoglikemijo, predvsem v prvem tednu po prehodu.
More severe episodes with coma, seizure, or neurologic impairment may be treated with intramuscular/subcutaneous glucagon or concentrated intravenous glucose. 
Hujše primere s komo, konvulzijami ali nevrološko prizadetostjo je mogoče zdraviti z glukagonom intramuskularno ali subkutano ali s koncentrirano glukozo intravensko.
If you find it hard to press the injection button in, do not force it as this may break your pen. 
Če gumb za injiciranje težko pritisnete noter, ne uporabite sile, ker lahko poškodujete peresnik.
Long-term improved glycaemic control decreases the risk of progression of diabetic retinopathy. 
Dolgoročno izboljšanje urejenosti glikemije zmanjša tveganje za napredovanje diabetične retinopatije.
Toujeo must not be mixed or diluted with any other insulin or other medicinal products. 
Zdravila Toujeo se ne sme mešati ali redčiti z nobenim drugim insulinom ali kakšnim drugim zdravilom.
Efficacy and safety data for paediatric patients with type 2 diabetes mellitus have been extrapolated from data for adolescent and adult patients with type 1 diabetes mellitus and adult patients with type 2 diabetes mellitus. 
Podatke o učinkovitosti in varnosti za pediatrične bolnike s sladkorno boleznijo tipa 2 so ekstrapolirali iz podatkov za mladostnike in odrasle bolnike s sladkorno boleznijo tipa 1 in iz podatkov za odrasle bolnike s sladkorno boleznijo tipa 2.
Change the injection site with each injection to help prevent these skin changes. 
Mesto injiciranja menjajte ob vsaki injekciji, da preprečite takšne kožne spremembe.
The frequency, type and severity of adverse reactions in the paediatric population do not indicate differences to the experience in the general diabetes population (see section 5.1). 
Pogostnost, vrsta in izrazitost neželenih učinkov se v pediatrični populaciji ne razlikujejo od tistih v splošni populaciji s sladkorno boleznijo (glejte poglavje 5.1).
Insulin and its analogues lower blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. 
Insulin in njegovi analogi zmanjšajo koncentracijo glukoze v krvi s spodbujanjem perifernega privzema glukoze, zlasti v skeletnem mišičju in maščevju, ter z zaviranjem tvorbe glukoze v jetrih.
These units are exclusive to Toujeo and are not the same as IU or the units used to express the potency of other insulin analogues (see section 5.1). 
Te enote veljajo izključno za zdravilo Toujeo in niso enake mednarodnim enotam (i.e.) ali enotam, ki se uporabljajo za izražanje jakosti drugih insulinskih analogov (glejte poglavje 5.1).
Get help from a person with good eye sight who is trained in using the pen. 
Pomaga naj vam oseba, ki dobro vidi in je usposobljena za uporabo peresnika.
• Low blood sugar means that there is not enough sugar in your blood. 
• Nizek krvni sladkor pomeni, da v krvi ni dovolj sladkorja.
IGlar: Insulin glargine 100 units/ml a Severe hypoglycaemia: Episode requiring assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions. 
IGlar: Insulin glargin 100 enot/ml a Huda hipoglikemija: hipoglikemija, ki zahteva pomoč druge osebe za aktivno uporabo ogljikovih hidratov, glukagona ali drugih rešilnih ukrepov.
- If you are allergic to insulin glargine or to any of the other ingredients of this medicine (listed in section 6). 
Ne uporabljajte zdravila Toujeo - Če ste alergični na insulin glargin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
Paediatric population Population pharmacokinetic analysis was conducted for Toujeo based on concentration data of its main metabolite M1 using data from 75 pediatric subjects (6 to <18 years of age) with type 1 diabetes. 
Populacijsko farmakokinetično analizo so za zdravilo Toujeo opravili na podlagi podatkov o koncentraciji njegovega glavnega presnovka M1; v ta namen so uporabili podatke 75 pediatričnih bolnikov (starih od 6 do < 18 let) s sladkorno boleznijo tipa 1.
After subcutaneous injection of insulin glargine, insulin glargine is rapidly metabolized at the carboxyl terminus of the Beta chain with formation of two active metabolites M1 (21A-Gly-insulin) and M2 (21A-Gly-des-30B-Thr-insulin). 
Po subkutanem injiciranju insulina glargin se ta hitro presnovi na karboksilnem koncu verige beta; nastaneta aktivna presnovka M1 (21A-Gly-insulin) in M2 (21A-Gly-des-30B-Thr-insulin).
Also lumps under the skin caused by build-up of a protein called amyloid may occur (cutaneous amyloidosis, how often they occur is not known). 
Zaradi kopičenja beljakovine imenovane amiloid, se lahko pojavijo podkožne grudice (kožna amiloidoza; ni znano, kako pogosto se pojavlja).
In the elderly, progressive deterioration of renal function may lead to a steady decrease in insulin requirements (see section 4.8 and 5.1). 
Pri starejših bolnikih lahko napredujoče slabšanje delovanja ledvic povzroči stalno zmanjševanje potrebe po insulinu (glejte poglavji 4.8 in 5.1).
Insulin glargine is metabolised into 2 active metabolites M1 and M2 (see section 5.2). 
Insulin glargin se presnovi v dva aktivna presnovka, M1 in M2 (glejte poglavje 5.2).
The MAH shall agree the final text and the context of the educational material for HCPs and patients together with a communication plan, with the National Competent Authority in each Member State prior to launch of the medicinal product. 
Imetnik dovoljenja za promet z zdravilom se mora o končnem besedilu in kontekstu izobraževalnega gradiva z zdravstvene delavce in bolnike ter o načrtu razdeljevanja dogovoriti s pristojnim nacionalnim organom v vsaki državi članici pred prihodom zdravila na trg.
• You inject too much insulin. 
• Injicirate si preveč insulina.
Solution for injection (injection). 
FARMACEVTSKA OBLIKA Raztopina za injiciranje (injekcija).
The half-life of Toujeo after subcutaneous injection is 18-19 hours independent of dose. 
Razpolovni čas zdravila Toujeo po subkutani injekciji je od 18 do 19 ur, neodvisno od odmerka.
Toujeo is not the insulin of choice for the treatment of diabetic ketoacidosis. 
Zdravilo Toujeo ni insulin prve izbire za zdravljenje diabetične ketoacidoze.
Tell your doctor, pharmacist or nurse if you notice any of the following side effects: 
Zdravniku, farmacevtu ali medicinski sestri povejte, če opazite katerega od naslednjih neželenih učinkov:
At the end of these treat-to-target trials, depending on the patient population and concomitant therapy, a 10-18% higher dose was observed in the Toujeo group than in the comparator group (Table 1 and 
Na koncu teh preskušanj z zdravljenjem do cilja so-odvisno od populacije bolnikov in sočasnih zdravil-v skupini z zdravilom Toujeo opažali od 10 do 18% večje odmerke kot v primerjalni skupini (preglednici 1 in 2).
This medicinal product contains less than 1 mmol (23 mg) sodium per dose, i.e. it is essentially ‘sodium-free'. 
Pomožne snovi To zdravilo vsebuje manj kot 1mmol (23mg) natrija na odmerek, kar v bistvu pomeni 'brez natrija'.
In many patients, the signs and symptoms of neuroglycopenia are preceded by signs of adrenergic counter-regulation. 
Številnim bolnikom se pred znaki in simptomi nevroglikopenije pojavijo znaki adrenergične protiregulacije.
Use only clear and colourless solutions. 
Uporabite samo bistro in brezbarvno raztopino.
• Key messages to convey in patients counselling: - Patients need to be instructed that insulin glargine 100 units/ml products and Toujeo are not interchangeable and dose adjustments need to be made; 
• Ključna sporočila, ki jih je treba posredovati pri svetovanju bolnikom: - Bolnikom je treba povedati, da zdravila z insulinom glargin 100 enot/ml in zdravilo Toujeo niso medsebojno zamenljivi in da je treba odmerek prilagoditi.
• Swelling in the calves and ankles, caused by temporary build-up of water in the body. 
• Otekanje meč in gležnjev - zaradi prehodnega kopičenja vode v telesu.
- That they should report medication errors or any side effects. 
- Napake pri uporabi zdravila in vsak neželen učinek morajo poročati.
This can help to spot mild hypoglycaemic episodes. 
To lahko pomaga odkriti epizode blage hipoglikemije.
• Beta-blockers or clonidine - for high blood pressure. 
• Blokatorje beta ali klonidin - za visok krvni tlak.
Switching a patient between another type or brand of insulin and Toujeo should be done under strict medical supervision. 
Prehod bolnika med drugimi vrstami ali znamkami insulinskega zdravila in zdravilom Toujeo sme potekati le pod strogim zdravniškim nadzorom.
• Eye reactions: A big change in your blood sugar control (getting better or worse) can disturb your vision. 
• Očesne reakcije - velika sprememba urejenosti krvnega sladkorja (izboljšanje ali poslabšanje) lahko povzroči motnjo vida.
• If there are not enough units left in your pen for your dose, the dose selector will stop at the number of units left. 
• Če v peresniku ni več dovolj enot insulina za vaš odmernik, se bo izbirnik odmerka ustavil na številu enot, ki so preostale.
If the SoloStar pen is damaged, has not been stored correctly, if you are not sure that it is working properly or you notice that your blood sugar control is unexpectedly getting worse: 
Če je peresnik SoloStar poškodovan, če ni bil pravilno shranjen, če niste prepričani, da deluje pravilno, ali če opazite, da se vam urejenost krvnega sladkorja nepričakovano poslabša:
• The other ingredients are: zinc chloride, metacresol, glycerol, water for injections, and sodium hydroxide (see section 2 “Important information about some of the ingredients of Toujeo”) and hydrochloric acid (for pH adjustment). 
• Druge sestavine so: cinkov klorid, metakrezol, glicerol, voda za injekcije in natrijev hidroksid (glejte poglavje 2, "Pomembne informacije o nekaterih sestavinah zdravila Toujeo") in klorovodikova kislina (za prilagoditev pH).
• In an insulin infusion pump. 
• V infuzijski črpalki za insulin.
Never select a dose or press the injection button without a needle attached. 
Nikdar ne izberite odmerka in tudi ne pritisnite gumba za injiciranje, če na peresniku ni nameščena igla.
Hydrochloric acid (for pH adjustment) Sodium hydroxide (for pH adjustment) Water for injections. 
Klorovodikova kislina (za prilagoditev pH) Natrijev hidroksid (za prilagoditev pH) Voda za injekcije.
In addition, under the influence of sympatholytic medicinal products such as beta-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counter-regulation may be reduced or absent. 
Poleg tega se lahko pod vplivom simpatikolitičnih zdravil, npr. zaviralcev adrenergičnih receptorjev beta, klonidina, gvanetidina in rezerpina, znaki adrenergične protiregulacije zmanjšajo ali izginejo.
• Keep new pens in a fridge, at 2°C to 8°C. 
• Nove peresnike shranjujte v hladilniku na temperaturi od 2 do 8 °C.
Signs in your brain include: headaches, feeling very hungry, feeling sick (nausea) or being sick (vomiting), feeling tired, sleepy, restless, sleeping problems, aggressive behaviour, difficulty concentrating, slow reactions, depression, feeling confused, difficulty speaking (sometimes total loss of speech), changes in your sight, trembling, being unable to move (paralysis), tingling in the hands or arms, feeling numb and tingling often around the mouth, feeling dizzy, loss of self-control, being unable to look after yourself, fits, passing out. 
Med znaki nizkega krvnega sladkorja v možganih so: glavobol, huda lakota, slabost v želodcu (siljenje na bruhanje) ali bruhanje, občutek utrujenosti, zaspanost, nemir, težave s spanjem, agresivno vedenje, težave z zbranostjo, počasne reakcije, depresija, občutek zmedenosti, težko govorjenje (včasih popolna izguba govora), spremembe vida, tresenje, nezmožnost gibanja (paraliza), mravljinčenje v rokah ali nogah, omrtvičenost in mravljinčenje, pogosto okrog ust, omotičnost, izguba samonadzora, nezmožnost poskrbeti zase, napadi krčev, nezavest.
The MAH shall ensure that in each Member State where Toujeo 300 units/ml is marketed, all healthcare professionals (HCPs) who are expected to prescribe or dispense Toujeo 300 units/ml, as well as all patients or their carers who are expected to use Toujeo 300 units/ml, are provided with educational material to address the risk(s) of Medication error (switching between 100 units/ml and 300 units/ml without dose adjustment). 
Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da bodo v vseh državah članicah, kjer se zdravilo Toujeo 300 enot/ml trži, vsi zdravstveni delavci, za katere se pričakuje, da bodo predpisovali ali izdajali zdravilo Toujeo 300 enot/ml, ter vsi bolniki ali njihovi skrbniki, za katere se pričakuje, da bodo uporabljali zdravilo Toujeo 300 enot/ml, prejeli izobraževalno gradivo, ki bo obravnavalo tveganje za napake pri uporabi zdravila (prehod med zdravilom s 100 enot/ml in zdravilom s 300 enot/ml brez prilagoditve odmerka).
• Angiotensin converting enzyme (ACE) inhibitors - for heart problems or high blood pressure. 
• Zaviralce angiotenzinske konvertaze (zaviralci ACE) - za težave s srcem ali visok krvni tlak.
• Throw the pen away and use a new one. 
• Zavrzite ta injekcijski peresnik in uporabite novega.
• Do not press at an angle - your thumb could block the dose selector from turning. 
• Ne pritiskajte pod kotom (od strani), kajti vaš palec lahko onemogoči vrtenje izbirnika odmerka.
• Fibrates - for lowering high levels of blood fats. 
• Fibrate - za znižanje visoke koncentracija maščob v krvi.
• a new sterile needle (see STEP 2). 
• nova, sterilna igla (glejte 2.
If the DoubleStar pen is damaged, has not been stored correctly, if you are not sure that it is working properly or you notice that your blood sugar control is unexpectedly getting worse: 
Če je peresnik DoubleStar poškodovan, če ni bil pravilno shranjen, če niste prepričani, da deluje pravilno, ali če opazite, da se vam urejenost krvnega sladkorja nepričakovano poslabša:
• Your insulin pen does not work properly. 
• Insulinski peresnik ne deluje pravilno.
Dose adjustment may also be required, for example, if the patient's weight or life-style changes, if there is a change in the timing of insulin dose or if other circumstances arise that increase susceptibility to hypo-or hyperglycaemia (see section 4.4). 
Prilagoditev odmerka je lahko potrebna tudi, če se npr. spremeni bolnikova telesna masa, slog življenja ali čas uporabe insulina, ali se pojavijo kakšne druge okoliščine, ki povečajo nagnjenost k hipo- ali hiperglikemiji (glejte poglavje 4.4).
Patients with type 2 diabetes mellitus The recommended daily starting dose is 0.2 units/kg followed by individual dose adjustments. 
Bolniki s sladkorno boleznijo tipa 2 Priporočeni začetni dnevni odmerek je 0,2 enoti/kg, nato je treba odmerek individualno prilagoditi.
Please refer to the prescribing information of the medicinal product to which the patient is switching. 
Glejte navodilo za uporabo zdravila, na katero prehaja bolnik.
Safety and efficacy of Toujeo have been demonstrated in a study in children aged 6 to less than 18 years. 
Varnost in učinkovitost zdravila Toujeo sta bili dokazani v študiji pri otrocih, starih od 6 do manj kot 18 let.
IGF-1 receptor binding: The affinity of insulin glargine for the human IGF-1 receptor is approximately 5 to 8-fold greater than that of human insulin (but approximately 70 to 80-fold lower than the one of IGF-1), whereas M1 and M2 bind the IGF-1 receptor with slightly lower affinity compared to human insulin. 
Vezava na receptorje za IGF-1: Afiniteta insulina glargin za človeški receptor IGF-1 je približno 5- do 8-krat večja kot afiniteta humanega insulina (vendar približno 70- do 80-krat manjša kot afiniteta IGF1), presnovka M1 in M2 pa se na receptor za IGF-1 vežeta z nekoliko manjšo afiniteto kot humani insulin.
If you are 65 years or older, talk to your doctor as you may need a lower dose. 
Uporaba pri starejših bolnikih (65 let in več) Če ste stari 65 let ali več, se posvetujte z zdravnikom, ker boste morda potrebovali manjši odmerek.
Beta-blockers like other “Sympatholytic medicines” (such as clonidine, guanethidine, reserpine - for high blood pressure) may make it harder to recognise warning signs of your blood sugar being too low (hypoglycaemia). 
Zaviralci beta lahko, tako kot druga simpatikolitična zdravila (npr. klonidin, gvanetidin, rezerpin - za visok krvni tlak), otežijo prepoznavanje opozorilnih znakov prenizkega krvnega sladkorja (hipoglikemije).
Based on the results from clinical studies, the safety profile of Toujeo in elderly patients and in patients with renal impairment was similar to that of the overall population (see section 5.1). 
Rezultati kliničnih študij kažejo, da so varnostne značilnosti zdravila Toujeo pri starejših bolnikih in bolnikih z okvaro ledvic podobne kot v splošni populaciji (glejte poglavje 5.1).
• For all injections, if no insulin comes out, the needle may be blocked. 
• Za vse injekcije, če iz konice še vedno ne priteče insulin, je igla morda zamašena.
*GIR: Glucose infusion rate: determined as amount of glucose infused to maintain constant plasma glucose levels (hourly mean values). 
*HIG: hitrost infundiranja glukoze; določena kot količina infundirane glukoze, potrebna za vzdrževanje stalne koncentracije glukoze v plazmi (povprečne urne vrednosti).
o To reduce potential underdose, Toujeo DoubleStar is recommended for patients requiring at least 20 units per day. 
o Za zmanjšanje možnosti premajhnega odmerjanja je injekcijski peresnik Toujeo DoubleStar priporočljiv za bolnike, ki potrebujejo vsaj 20 enot na dan.
In patients with type 2 diabetes mellitus, Toujeo can also be given together with other anti-hyperglycaemic medicinal products. 
Pri bolnikih s sladkorno boleznijo tipa 2 je mogoče zdravilo Toujeo uporabljati tudi skupaj z drugimi antihiperglikemičnimi zdravili.
• You can see roughly how many units of insulin are left by looking at where the plunger is on the insulin scale. 
• Koliko enot insulina je še preostalo, lahko približno ocenite tako, da pogledate, kje ob merilu insulina je bat.
Please, see also section 2. 
Prosimo, glejte tudi poglavje 2.
• Monoamine oxidase inhibitors (MAOIs) - for depression. 
• Zaviralce monoaminooksidaze (zaviralci MAO) - za depresijo.
• You are taking or have taken certain other medicines (see section 2, "Other medicines and 
• jemljete ali ste jemali določena druga zdravila (glejte poglavje 2, "Druga zdravila in zdravilo
Always carry a spare pen and spare needles in case they get lost or stop working. 
Vedno imejte pri sebi rezervni peresnik in rezervne igle za primer, da peresnik izgubite ali da neha delovati.
What Toujeo is and what it is used for 
Kaj je zdravilo Toujeo in za kaj ga uporabljamo
• Keep your pen at room temperature, below 30°C. 
• Peresnik shranjujte na sobni temperaturi do 30 °C.
Pregnancy There is no clinical experience with use of Toujeo in pregnant women. 
Nosečnost Kliničnih izkušenj z uporabo zdravila Toujeo pri nosečnicah ni.
• Your low blood sugar comes on slowly. 
• se vam krvni sladkor znižuje počasi,
Based on your lifestyle, your blood sugar tests and your previous insulin use, your doctor will tell you: 
Zdravnik vam bo glede na vaš slog življenja, izvide, meritev krvnega sladkorja in prejšnjo uporabo insulina povedal:
Since Toujeo is a clear solution, it does not require resuspension before use. 
Zdravilo Toujeo je bistra raztopina, zato pred uporabo ne potrebuje resuspendiranja.
Toujeo DoubleStar is made to deliver the number of insulin units that your doctor prescribed. 
Peresnik Toujeo DoubleStar je izdelan, da odmeri število enot insulina, ki vam jih je predpisal zdravnik.
900 units per pen 
900 enot na peresnik
b Confirmed hypoglycaemia: Any severe hypoglycaemia and/or hypoglycaemia confirmed by plasma glucose value ≤3.9 mmol/l. 
b Potrjena hipoglikemija: katera koli huda hipoglikemija in/ali hipoglikemija, potrjena z vrednostjo glukoze v plazmi ≤
• The Toujeo SoloStar pen contains 450 units of Toujeo. 
• Peresnik Toujeo SoloStar vsebuje 450 enot zdravila Toujeo.
Mean dose of insulin glargine 100 units/ml by study end was 0.42 U/kg. 
Povprečni odmerek insulina glargin 100 enot/ml je bil ob koncu študije 0,42 E/kg.
The pharmacokinetic and pharmacodynamic findings indicate that the effect of the subcutaneous injection with insulin glargine is principally based on exposure to M1. Insulin glargine and the metabolite M2 were not detectable in the vast majority of subjects and, when they were detectable their concentration was independent of the administered dose and formulation of insulin glargine. 
Farmakokinetični in farmakodinamski izsledki kažejo, da učinek subkutano injiciranega insulina glargin temelji predvsem na izpostavljenosti presnovku M1. Insulin glargin in presnovek M2 pri veliki večini preiskovancev nista bila zaznavna; če sta bila zaznavna, pa njuna koncentracija ni bila odvisna od uporabljenega odmerka in oblike insulina glargin.
If you notice signs of your blood sugar being too low (hypoglycaemia), take action to increase your blood sugar level straight away (see the box at the end of this leaflet). 
Če opazite znake prenizkega krvnega sladkorja (hipoglikemije), ukrepajte tako, da boste koncentracijo krvnega sladkorja takoj zvišali (glejte okvir na koncu tega navodila).
• Diazoxide - for high blood pressure. 
• Diazoksid - za visok krvni tlak.
At baseline, participants had a median HbA1c value of 6.4% and median on-treatment HbA1c values ranged from 5.9 to 6.4% in the insulin glargine 100 units/ml group, and 6.2% to 6.6% in the standard care group throughout the duration of follow-up. 
Izhodiščno so imeli preiskovanci mediano vrednost HbA1c 6,4 %; mediana vrednost HbA1c med zdravljenjem je segala od 5,9 do 6,4 % v skupini z insulinom glargin 100 enot/ml in od 6,2 % do 6,6 % v skupini s standardno oskrbo med celotnim trajanjem spremljanja.
The dose-response analysis showed that following the initial titration phase, the body weight adjusted doses in pediatric patients are higher than in adult patients at steady state. 
Analiza odmerka in odziva je pokazala, da je pri pediatričnih bolnikih na telesno maso prilagojeni odmerek po uvodni titracijski fazi v stanju dinamičnega ravnovesja večji kot pri odraslih.