natgillin/translations-raw huggingface dataset:
This can cause weakness, bruising or make infections more likely. 
Posledice so lahko šibkost, podplutbe ali večja verjetnost okužb.
However, side effects such as dizziness and visual disturbances may uncommonly occur (see section 4). 
Kljub temu pa se lahko občasno pojavijo neželeni učinki kot so omotica in motnje vida (glejte poglavje 4).
In case of clopidogrel, a prodrug which is transformed into its active metabolite via CYP2C19, the plasma concentrations of the active metabolite may be decreased. 
V primeru klopidogrela, ki je predzdravilo in se presnovi v aktivni presnovek s pomočjo CYP2C19, je koncentracija aktivnega metabolita v plazmi lahko zmanjšana.
• You may need to take the capsules for 2 or 3 days in a row before your reflux symptoms (for example, heartburn and acid regurgitation) get better. 
• Morda boste morali kapsule jemati 2 ali 3 dni zapored, preden se vam simptomi refluksa (na primer, zgaga ali regurgitacija kisline) izboljšajo.
• Enlarged breasts in men 
• povečanje dojk pri moških
The CYP2C19 and CYP3A4 inhibitor voriconazole increased omeprazole AUCt by 280%. 
Zaviralec CYP2C19 in CYP3A4 vorikonazol je povečal AUCt omeprazola za 280 %.
It is unknown whether esomeprazole/metabolites are excreted in human milk. 
Ni znano, ali se esomeprazol ali njegovi presnovki pri človeku izločajo v materino mleko.
Concomitant administration of 30 mg esomeprazole resulted in a 45% decrease in clearance of the CYP2C19 substrate diazepam. 
Sočasna uporaba 30 mg esomeprazola je za 45 % zmanjšala očistek diazepama, ki je substrat CYP2C19.
Non-clinical data reveal no particular hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, and toxicity to reproduction and development. 
Predklinični podatki na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih se odmerkih, genotoksičnosti in toksičnosti za reprodukcijo in razvoj ne kažejo posebnega tveganja za človeka.
What Nexium Control is and what it is used for 
Kaj je zdravilo Nexium Control in za kaj ga uporabljamo
Increased gastric pH during omeprazole treatment may change the absorption of the protease inhibitors. 
Zvišanje želodčnega pH med zdravljenjem z omeprazolom lahko spremeni absorpcijo zaviralcev proteaz.
The glass should be rinsed with half a glass of water and the water drunk. 
Kozarec je nato treba splakniti s pol kozarca vode in to vodo popiti.
Blood and lymphatic system disorders leukopenia, thrombocytopenia agranulocytosis, pancytopenia 
Bolezni krvi in limfatičnega sistema levkopenija, trombocitopenija agranulocitoza, pancitopenija
• You may need to take the tablets for 2 or 3 days in a row before your reflux symptoms (for example, heartburn and acid regurgitation) get better. 
• Morda boste morali tablete jemati 2 ali 3 dni zapored, preden se vam simptomi refluksa (na primer, zgaga ali regurgitacija kisline) izboljšajo.
In high-dose methotrexate administration a temporary withdrawal of esomeprazole may need to be considered. 
Med visokoodmernim zdravljenjem z metotreksatom je lahko potrebno prehodno prenehanje uporabe esomeprazola.
After repeated once-daily administration of 40 mg esomeprazole, the mean area under the plasma concentration-time curve was approximately 100% higher in poor metabolisers than in subjects having a functional CYP2C19 enzyme (extensive metabolisers). 
Po ponavljajoči se uporabi 40 mg esomeprazola, enkrat na dan, je povprečna površina pod krivuljo plazemske koncentracije po času pri slabih metabolizatorjih približno 100 % večja kot pri osebah s funkcionalnim encimom CYP2C19 (dobrih metabolizatorjih).
Mean peak plasma concentrations were 60% higher. 
Povprečna največja koncentracija v plazmi je 60 % večja.
Esomeprazole must not be used concomitantly with nelfinavir (see section 4.5). 
Esomeprazola se ne sme uporabljati sočasno z nelfinavirjem (glejte poglavje 4.5).
• Yellow skin, dark urine and tiredness, which can be symptoms of liver problems, seen rarely. 
• porumenelost kože, temen urin in utrujenost; to so lahko simptomi težav z jetri, pojavijo se redko
Omeprazole (40 mg once daily) increased voriconazole (a CYP2C19 substrate) Cmax and AUCτ by 15% and 41%, respectively. 
Omeprazol (40 mg enkrat na dan) je povečal Cmax vorikonazola (substrata CYP2C19) za 15 % in njegovo AUCτ za 41 %.
Other medicines and Nexium Control 
Druga zdravila in zdravilo Nexium Control
Carcinogenicity studies in the rat with the racemic mixture have shown gastric ECL-cell hyperplasia and carcinoids. 
Pri podganah so študije kancerogenosti z uporabo racemne mešanice pokazale hiperplazijo želodčnih enterokromafinim podobnih celic in karcinoide.
In both studies esomeprazole 20 mg was significantly better compared to placebo for the primary endpoint, complete resolution of heartburn, defined as no heartburn episodes during the last 7 days prior to the final visit (33.9% - 41.6% vs. placebo 11.9 - 13.7%, (p<0.001). 
V obeh študijah je bil esomeprazol 20 mg pomembno boljši v primerjavi s placebom pri primarnem opazovanem dogodku, popolnem prenehanju zgage, opredeljenem kot odsotnost epizod zgage v zadnjih 7 dneh pred končnim obiskom (33,9-41,6 % v primerjavi s placebom 11,9-13,7 % (p < 0,001)).
Approximately 78% of the subjects on 20 mg esomeprazole reported first resolution of heartburn within the first week of treatment compared to 52 - 58% for placebo. 
Približno 78 % preiskovancev, ki so dobivali 20 mg esomeprazola, je poročalo o prvem prenehanju zgage v prvem tednu zdravljenja v primerjavi z 52-58 % preiskovancev, ki so dobivali placebo.
Treatment with proton pump inhibitors (PPIs) may lead to a slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter and in hospitalised patients, also possibly Clostridium difficile (see section 5.1). 
Zdravljenje z zaviralci protonske črpalke lahko rahlo poveča tveganje za okužbe prebavil, npr. z bakterijami Salmonella in Campylobacter ter pri hospitaliziranih bolnikih morda tudi s Clostridium difficile (glejte poglavje 5.1).
• Diazepam (used to treat anxiety, relax muscles or in epilepsy) 
• diazepam (uporablja se za zdravljenje tesnobnosti, za sproščanje mišic ali pri epilepsiji)
Esomeprazole has been shown to have no clinically relevant effects on the pharmacokinetics of amoxicillin and quinidine. 
Esomeprazol nima klinično pomembnega učinka na farmakokinetiko amoksicilina in kinidina.
Animal studies with the racemic mixture omeprazole, given by oral administration do not indicate effects with respect to fertility. 
Študije na živalih, v katerih so uporabljali racemno mešanico omeprazola peroralno, niso pokazale vplivov na plodnost.
Effects of other medicinal products on the pharmacokinetics of esomeprazole Medicinal products which inhibit CYP2C19 and/or CYP3A4 
Učinki drugih zdravil na farmakokinetiko esomeprazola Zdravila, ki zavirajo CYP2C19 in/ali CYP3A4
However, caution should be exercised when esomeprazole is given at high doses in elderly patients. 
Vendar pa je v primeru uporabe velikih odmerkov esomeprazola pri starejših bolnikih potrebna previdnost.
There is no relevant use of Nexium Control in the paediatric population below 18 years of age for the indication of “short-term treatment of reflux symptoms (e.g., heartburn and acid regurgitation)”. 
Zdravilo Nexium Control ni namenjeno za uporabo pri pediatrični populaciji, mlajši od 18 let, za indikacijo “kratkotrajnega zdravljenja simptomov refluksa (npr. zgage in regurgitacije kisline)”.
No studies have been performed in patients with decreased renal function. 
Študij pri bolnikih z zmanjšanim delovanjem ledvic ni bilo.
High-density polyethylene (HDPE) bottle with an induction seal closure and child resistant closure containing 14 gastro-resistant capsules. 
Plastenka iz polietilena visoke gostote (HDPE) z indukcijsko zaporko s tesnilom in za otroke varno zaporko, ki vsebuje 14 gastrorezistentnih kapsul.
The plasma elimination half-life is about 1.3 hours after repeated once-daily dosing. 
Plazemski eliminacijski razpolovni čas po večkratnem odmerjanju enkrat na dan je okrog 1,3 ure.
Patients should not take another PPI or H2 antagonist concomitantly. 
Bolniki sočasno ne smejo jemati kakšnega drugega zaviralca protonske črpalke ali antagonista histaminskih receptorjev H2.
Elderly patients (≥65 years old) The metabolism of esomeprazole is not significantly changed in elderly patients (71-80 years of age). 
Starejši bolniki (stari 65 let ali več) Pri starejših osebah (71-80 let) presnova esomeprazola ni bistveno spremenjena.
Excipient(s) with known effect Each gastro-resistant tablet contains 28 mg sucrose. 
Pomožne snovi z znanim učinkom: Ena gastrorezistentna tableta vsebuje 28 mg saharoze.
Nexium Control is available in pack sizes of 7 and 14 gastro-resistant tablets in blisters. 
Zdravilo Nexium Control je na voljo v velikostih pakiranj s 7 in 14 gastrorezstentnimi tabletami v pretisnih omotih.
Esomeprazole 20 mg has been demonstrated to effectively treat frequent heartburn in subjects receiving one dose per 24 hours over 2 weeks. 
Dokazali so, da 20 mg esomeprazola učinkovito zdravi pogosto zgago pri preiskovancih, ki so 2 tedna dobivali en odmerek na 24 ur.
Pack sizes of 7 and 14 gastro-resistant tablets. 
Velikosti pakiranj s 7 in 14 gastrorezistentnimi tabletami.
• You have been taking treatment continuously for reflux or heartburn for 4 or more weeks. 
• jemljete zdravilo proti refluksu ali zgagi nepretrgoma že 4 tedne ali več,
Following a single dose of 40 mg esomeprazole the mean are under the plasma concentration-time curve is approximately 30% higher in females than in males. 
Po enkratnem odmerku 40 mg esomeprazola je povprečna površina pod krivuljo plazemske koncentracije po času pri ženskah približno 30 % večja kot pri moških.
Treatment with PPIs may lead to slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter and in hospitalised patients, also possibly Clostridium difficile. 
Zdravljenje z zaviralci protonske črpalke lahko rahlo poveča tveganje okužb prebavil, npr. z bakterijami, kakršne so Salmonella in Campylobacter, pri hospitaliziranih bolnikih pa morda tudi s Clostridium difficile.
Gastric acid suppression during treatment with esomeprazole and other PPIs might decrease or increase the absorption of medicinal products with a gastric pH dependent absorption. 
Zavrtje izločanja želodčne kisline med zdravljenjem z esomeprazolom in drugimi zaviralci protonske črpalke lahko zmanjša ali poveča absorpcijo zdravil, katerih absorpcija je odvisna od pH v želodcu.
As a precautionary measure, it is preferable to avoid the use of Nexium Control during pregnancy. 
Zaradi previdnosti je bolje, da se zdravila Nexium Control med nosečnostjo ne uporablja.
• They have significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis or melaena and when gastric ulcer is suspected or present, malignancy should be excluded as treatment with esomeprazole may alleviate symptoms and delay diagnosis. 
• v primeru izrazitega in nenamernega hujšanja, ponavljajočega se bruhanja, disfagije, hematemeze ali melene in pri sumu na želodčni ulkus ali ugotovljenem želodčnem ulkusu; v takšnem primeru je treba izključiti maligno bolezen, kajti zdravljenje z esomeprazolom lahko ublaži simptome in zapozni postavitev diagnoze.
If affected, you should not drive or use machines. 
Če imate takšne neželene učinke, ne upravljajte vozil ali strojev.
Studies evaluating concomitant administration of esomeprazole and either naproxen or rofecoxib did not identify any clinically relevant pharmacokinetic interactions during short-term studies. 
Študije sočasne uporabe esomeprazola z naproksenom ali rofekoksibom med kratkotrajnimi študijami niso pokazale klinično pomembnih farmakokinetičnih medsebojnih delovanj.
Results from studies in healthy subjects have shown a pharmacokinetic (PK)/pharmacodynamic (PD) interaction between clopidogrel (300 mg loading dose/75 mg daily maintenance dose) and esomeprazole (40 mg orally daily) resulting in decreased exposure to the active metabolite of clopidogrel by an average of 40%, and resulting in decreased maximum inhibition of (ADP induced) platelet aggregation by an average of 14%. 
Rezultati študije pri zdravih preiskovancih so pokazali farmakokinetično (FK)/farmakodinamično (FD) medsebojno delovanje med klopidogrelom (300 mg polnilni odmerek/75 mg dnevni vzdrževalni odmerek) in esomeprazolom (40 mg na dan peroralno), ki je zmanjšalo izpostavljenost aktivnemu presnovku klopidogrela za povprečno 40 % in je posledično zmanjšalo največje zavrtje (z ADP inducirane) agregacije trombocitov za povprečno 14 %.
Hepatobiliary disorders increased liver enzymes hepatitis with or without jaundice hepatic failure, hepatic encephalopathy in patients with pre-existing liver disease 
Bolezni jeter, žolčnika in žolčevodov zvišanje jetrnih encimov hepatitis z zlatenico ali brez nje odpoved jeter, hepatična encefalopatija pri bolnikih s predobstoječo boleznijo jeter
• Reddening of the skin with blisters or peeling. 
• pordelost kože z mehurji ali lupljenjem.
• They are aged over 55 years with new or recently changed symptoms. 
• če so starejši od 55 let in se jim pojavijo novi simptomi ali so se jim simptomi nedavno spremenili.
If you forget to take Nexium Control 
Če ste pozabili vzeti zdravilo Nexium Control
• Try to lose weight. 
• poskusite zmanjšati telesno maso;
After repeated administration with 20 mg esomeprazole once daily for five days, mean peak acid output after pentagastrin stimulation is decreased 90% when measured 6-7 hours after dosing on day five. 
Po večkratni uporabi 20 mg esomeprazola enkrat na dan pet dni se povprečno največje izločanje kisline po stimulaciji s pentagastrinom, merjeno peti dan od 6 do 7 ur po odmerku, zmanjša za 90 %.
• An infection called “thrush” which can affect the gut and is caused by a fungus. 
• okužba, ki jo imenujemo "gobice" in lahko prizadene črevo; povzročajo jo glivice
• Digoxin (used for heart problems) 
• digoksin (uporablja se za zdravljenje težav s srcem)
The normal symptoms of reflux are a painful sensation in the chest rising up to your throat (heartburn) and a sour taste in the mouth (acid regurgitation). 
Običajni simptomi refluksa so bolečina v prsnem košu, ki se širi proti žrelu (zgaga) in kisel okus v ustih (vračanje kisline).
This is because the capsule contains coated pellets, which stop the medicine from being broken down by the acid in your stomach. 
Kapsula namreč vsebuje obložena zrnca, ki preprečijo, da bi kislina v želodcu razgradila zdravilo.
• They have jaundice or severe liver disease. 
• če imajo zlatenico ali hudo bolezen jeter.
• Effects on your stomach or gut: diarrhoea, stomach ache, constipation, wind (flatulence). 
• učinki na želodec ali črevo: driska, bolečine v trebuhu, zaprtost, vetrovi (flatulenca)
This medicine is used in adults for the short-term treatment of reflux symptoms (for example, heartburn and acid regurgitation). 
To zdravilo se uporablja pri odraslih za kratkotrajno zdravljenje simptomov refluksa (npr. zgage in vračanja kisline).
Concomitant administration of 40 mg esomeprazole resulted in a 13% increase in trough plasma levels of phenytoin in epileptic patients. 
Sočasna uporaba 40 mg esomeprazola je pri bolnikih z epilepsijo povečala koncentracijo fenitoina v plazmi za 13 %.
Medicinal products known to induce CYP2C19 or CYP3A4 or both (such as rifampicin and St. John's wort (Hypericum perforatum)) may lead to decreased esomeprazole serum levels by increasing the esomeprazole metabolism. 
Zdravila, ki inducirajo CYP2C19, CYP3A4 ali oba (npr. rifampicin in šentjanževka (Hypericum perforatum)), lahko zmanjšajo koncentracijo esomeprazola v serumu, ker povečajo njegovo presnovo.
• You begin to vomit food or blood, which may appear as dark coffee grounds in your vomit. 
• bruhanje hrane ali krvi; ta je lahko opazna kot temna, kavi podobna zrna v izbruhani vsebini,
Musculoskeletal and connective tissue disorders arthralgia, myalgia muscular weakness 
Bolezni mišičnoskeletnega sistema in vezivnega tkiva artralgija, mialgija mišična šibkost
What you need to know before you take Nexium Control 
Kaj morate vedeti, preden boste vzeli zdravilo Nexium Control
Aluminium blister. 
Aluminijasti pretisni omot.
You may need to take the capsules for 2-3 days in a row before you feel better. 
Morda boste morali kapsule jemati 2 ali 3 dni zapored, preden se boste počutili bolje.
The liquid with the pellets should be drunk immediately or within 30 minutes. 
Vodo je treba mešati, dokler se tableta ne razpusti, tekočino z zrnci pa je treba popiti takoj ali v 30 minutah.
This is because the tablet contains coated pellets, which stop the medicine from being broken down by the acid in your stomach. 
Tableta namreč vsebuje obložena zrnca, ki preprečijo, da bi kislina v želodcu razgradila zdravilo.
EU/1/13/860/001 7 gastro-resistant tablets EU/1/13/860/002 14 gastro-resistant tablets 
EU/1/13/860/001 7 gastrorezistentnih tablet EU/1/13/860/002 14 gastrorezistentnih tablet
• You have severe kidney problems. 
• imate hudo okvaro ledvic,
• You are aged over 55 years and have new or recently changed reflux symptoms or need to take a non-prescription indigestion or heartburn remedy treatment every day. 
• ste starejši od 55 let in se vam pojavijo novi simptomi refluksa ali se vam takšni simptomi v zadnjem času spremenijo ali vsak dan jemljete zdravila proti težavam z želodcem ali zgago, ki ste jih dobili brez recepta,
In a study in healthy subjects, there was a decreased exposure by almost 40% of the active metabolite of clopidogrel when a fixed dose combination of esomeprazole 20 mg + acetylsalicylic acid 81 mg was given with clopidogrel compared to clopidogrel alone. 
V študiji pri zdravih preiskovancih se je izpostavljenost aktivnemu presnovku klopidogrela v primeru uporabe fiksnega odmerka kombinacije 20 mg esomeprazola in 81 mg acetilsalicilne kisline skupaj s klopidogrelom zmanjšala za skoraj 40 % v primerjavi z uporabo samega klopidogrela.
Immune system disorders hypersensitivity reactions e.g. fever, angioedema and anaphylactic reaction/shock 
Bolezni imunskega sistema preobčutljivostne reakcije, npr. zvišana telesna temperatura, angioedem in anafilaktična reakcija/šok
Take one tablet once a day. 
Vzemite eno tableto enkrat na dan. Ne prekoračite tega odmerka.
Take one capsule once a day. 
Vzemite eno kapsulo enkrat na dan. Ne prekoračite tega odmerka.
• Rash, possibly with pain in the joints. 
• izpuščaj, lahko z bolečino v sklepih
Reproductive system and breast disorders gynaecomastia 
Motnje reprodukcije in dojk ginekomastija
General disorders and administration site disorders malaise, increased sweating 
Splošne težave in spremembe na mestu aplikacije splošno slabo počutje, močnejše znojenje
• Voriconazole (used to treat infections caused by a fungus) and clarithromycin (used to treat infections). 
• vorikonazol (uporablja se za zdravljenje glivičnih okužb) in klaritromicin (uporablja se za zdravljenje okužb).
About 80% of nights were heartburn free during all time periods and 90% of nights were heartburn free by week 2 of each clinical study, compared to 72.4 - 78.3% for placebo. 
V obeh kliničnih študijah je bilo približno 80 % vseh noči brez zgage v vseh časovnih obdobjih, po 2 tednih pa je bilo 90 % noči brez zgage v primerjavi z 72,4-78,3% v skupini s placebom.
• Benign growths (polyps) in the stomach. 
• benigni polipi v želodcu
Concomitant administration of 40 mg esomeprazole to warfarin-treated patients in a clinical study showed that coagulation times were within the accepted range. 
Pri bolnikih, ki so v klinični študiji hkrati dobivali 40 mg esomeprazola in varfarin, so ugotovili koagulacijske čase v sprejemljivem razponu.
Decreased gastric acidity due to any means including PPIs, increases gastric counts of bacteria normally present in the gastrointestinal tract. 
Če se kislost v želodcu zmanjša zaradi kakršnegakoli vzroka, vključno z zaviralci protonske črpalke, se v želodcu poveča število bakterij, ki so običajno prisotne v prebavilih.
- If you are taking a medicine containing nelfinavir (used to treat HIV infection). 
- Če jemljete kakšno zdravilo, ki vsebuje nelfinavir (uporablja se za zdravljenje okužbe s HIV).
Omeprazole has been reported to interact with some protease inhibitors. 
Opisano je, da omeprazol medsebojno deluje z nekaterimi zaviralci proteaz.
The capsules must not be chewed, crushed or opened. 
Kapsul se ne sme žvečiti, zdrobiti ali odpreti.
For short-term treatment of reflux symptoms (heartburn, acid regurgitation) in adults, aged 18 or over. 
Za kratkotrajno zdravljenje simptomov refluksa (zgage, vračanja kisline) pri odraslih, starejših od 18 let.
Nexium Control is available in a pack size of 14 gastro-resistant hard capsules in high-density polyethylene (HDPE) bottles with an induction seal closure and child resistant closure. 
Zdravilo Nexium Control je na voljo v pakiranju s 14 trdimi gastrorezistentnimi kapsulami v plastenkah iz polietilena visoke gostote (HDPE) z indukcijsko zaporko s tesnilom in za otroke varno zaporko.
Nexium Control is indicated for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults. 
Zdravilo Nexium Control je indicirano za kratkotrajno zdravljenje simptomov refluksa (npr. zgage in regurgitacije kisline) pri odraslih.
As a precaution, concomitant use of esomeprazole and clopidogrel should be discouraged. 
Zaradi previdnosti naj esomeprazola in klopidogrela ne bi uporabljali sočasno.
• Citalopram, imipramine or clomipramine (used to treat depression) 
• citalopram, imipramin ali klomipramin (uporabljajo se za zdravljenje depresije)
The tablets must not be chewed or crushed. 
Tablet se ne sme žvečiti ali zdrobiti.
It is important for you to give information about your medicine at this time. 
V takšnem primeru je pomembno, da zdravnika obvestite, da jemljete to zdravilo.
• Sudden wheezing, swelling of your lips, tongue and throat, rash, fainting, or difficulties in swallowing (severe allergic reaction, seen rarely). 
• nenadno piskajoče dihanje, oteklost ustnic, jezika in žrela, izpuščaj, omedlevico ali težave s požiranjem (huda alergijska reakcija, pojavi se redko)
Medicinal products which induce CYP2C19 and/or CYP3A4 
Zdravila, ki inducirajo CYP2C19 in/ali CYP3A4
A light pink, oblong, biconvex, film-coated, gastro-resistant tablet of 14 mm x 7 mm engraved with ‘20 mG' on one side and ‘A/EH' on the other side. 
Svetlorožnata, podolgovata, bikonveksna filmsko obložena gastrorezistentna tableta velikosti 14 mm x 7 mm z vtisnjeno oznako "20 mG" na eni strani in "A/EH" na drugi strani.
Keep this medicine in the original package in order to protect from moisture. 
Zdravilo shranjujte v originalni ovojnini za zagotovitev zaščite pred vlago.
As a precautionary measure, you should preferably avoid the use of Nexium Control during pregnancy. 
Zaradi previdnosti je priporočljivo, da se jemanju zdravila Nexium Control med nosečnostjo izognete.
SCLE after previous treatment with a proton pump inhibitor may increase the risk of SCLE with other proton pump inhibitors. 
Subakutni kožni eritematozni lupus po predhodnem zdravljenju z zaviralcem protonske črpalke lahko poveča tveganje za pojav subkutanega kožnega eritematoznega lupusa z drugimi zaviralci protonske črpalke.
Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H 
V močno kislem okolju sekretornih kanalčkov parietalnih celic se koncentrira in pretvori v aktivno obliko ter zavira encim H
• Atazanavir, saquinavir (used to treat HIV infection) 
• atazanavir, sakvinavir (uporabljata se za zdravljenje okužbe s HIV)
Concomitant administration of esomeprazole and a combined inhibitor of CYP2C19 and CYP3A4 may result in more than doubling of the esomeprazole exposure. 
Sočasna uporaba esomeprazola in kakšnega kombiniranega zaviralca CYP2C19 in CYP3A4 lahko več kot podvoji izpostavljenost esomeprazolu.
The major metabolites of esomeprazole have no effect on gastric acid secretion. 
Glavni presnovki esomeprazola ne vplivajo na izločanje želodčne kisline.