natgillin/translations-raw huggingface dataset:
Gout flares may occur after initiation of therapy with Duzallo. 
Po uvedbi zdravila Duzallo se lahko pojavijo napadi protina.
azathioprine - vidarabine, used to treat herpes or chickenpox - cytostatics (e.g. cyclophosphamide, doxorubicin, bleomycin, procarbazine, alkylating agents, mercaptopurine), used to treat cancer or rheumatic diseases - aluminium hydroxide, used to treat heartburn and acid indigestion (you should leave an interval of at least 3 hours between taking the two medicines) 
merkaptopurin), ki se uporabljajo za zdravljenje raka in revmatskih obolenj; - aluminijev hidroksid, ki ga uporabljamo pri zgagi in refluksu (med jemanjem enega in drugega zdravila morajo preteči vsaj 3 ure)
Lesinurad 200 mg vs. placebo 
Lesinurad 200 mg v primerjavi s placebom
Kidney problems 
Težave z ledvicami
Time from Baseline in Months placebo (4.2%), resulting in discontinuation of treatment in 1.0% for both treatment setups (see section 
O neželenih učinkih v povezavi z ledvicami so poročali pri bolnikih, ki so prejemali 200 mg lesinurada (4,9%), v primerjavi z bolniki, ki so prejemali placebo (4,2%); ti neželeni učinki so povzročili prenehanje zdravljenja pri 1,0% bolnikov iz obeh terapevtskih skupin (glejte poglavje 4.4).
Over time, your gout attacks will occur less often if you keep taking Duzallo as advised by your doctor. 
Če boste zdravilo Duzallo še naprej jemali, kot vam je svetoval zdravnik, bodo napadi protina sčasoma postali manj pogosti.
Gastrooesophageal reflux disease 
Žilne bolezni hipertenzija
Uncommon - may affect up to 1 in 100 people - kidney stones, - kidney stop working properly, - skin reactions, including redness, itchy skin, lumpy rash (hives) and skin rash on exposure to sunshine, - dehydration (loss of too much fluid from your body), - feeling sick (nausea) or being sick (vomiting), - diarrhoea, - abnormal liver tests. 
- ledvični kamni, - slabše delovanje ledvic, - kožne reakcije, vključno s pordelostjo, srbenjem, dvignjenim izpuščajem (koprivnico) in izpuščajem na koži po izpostavljenosti soncu, - dehidracija (prekomerna izguba tekočine iz telesa), - slabost v želodcu (siljenje na bruhanje) ali bruhanje, - driska, - nenormalni jetrni testi,
CYP2C9 poor metabolisers 
Slabi presnavljalci s CYP2C9
Recurrent haematemesis, steatorrhoea, stomatitis, changed stool frequency 
Bolezni prebavil gastroezofagea lna refluksna bolezen navzea, bruhanje in driska ponavljajoča se hematemeza, steatoreja, stomatitis, spremenjena pogostnost odvajanja blata
Duzallo 300 mg/200 mg film-coated tablets 
Duzallo 300 mg/200 mg filmsko obložene tablete
Duzallo 200 mg/200 mg film-coated tablets 
Duzallo 200 mg/200 mg filmsko obložene tablete
What Duzallo looks like and contents of the pack Duzallo 200 mg/200 mg film-coated tablets are pale pink oblong tablets and engraved with “LES200” and “ALO200” on one side. 
Duzallo 200 mg/200 mg filmsko obložene tablete so bledo rožnate, podolgovate tablete in imajo na eni strani vgravirana napisa »LES200« in »ALO200«.
Renal failure***, renal impairment, nephrolithiasis 
Bolezni sečil odpoved ledvic***, okvara ledvic, nefrolitiaza urolitiaza hematurija, azotemija
Duzallo should be interrupted if serum creatinine is elevated to more than 2 times the pre-treatment value or in case of an absolute serum creatinine value greater than 4.0 mg/dL. 
Uporabo zdravila Duzallo je treba prekiniti, če se kreatinin v serumu zviša na več kot 2-kratno vrednost, kot je bila pred zdravljenjem, prav tako tudi v primeru absolutne vrednosti kreatinina v serumu nad 4,0 mg/dl. Zdravljenje je treba prekiniti pri bolnikih s simptomi, ki lahko kažejo na akutno urično nefropatijo: npr. z bolečinami v ledvenem predelu, navzeo ali bruhanjem; v tem primeru je treba takoj izmeriti kreatinin v serumu.
In two 12-month placebo-controlled trials of lesinurad in combination with allopurinol versus allopurinol alone (placebo), serum creatinine elevations between 1.5-fold and 2-fold over baseline occurred in 4.4% of patients on lesinurad 200 mg and 2.2% on placebo; serum creatinine elevations 2fold or greater over baseline occurred in 1.5% of patients on lesinurad 200 mg and 0% on placebo. 
V teh preskušanjih se je zvišanje kreatinina v serumu, ki je bilo od 1,5- do 2-kratnik izhodiščnega, pojavilo pri 4,4% bolnikov, ki so prejemali 200 mg lesinurada, in pri 2,2% bolnikov, ki so prejemali placebo.
Oedema, general malaise, asthaenia 
Splošne težave in spremembe na mestu aplikacije edem, splošno slabo počutje, astenija
Duzallo does not need to be discontinued because of a gout flare. 
Zaradi napada protina zdravila Duzallo ni treba prenehati uporabljati.
What Duzallo looks like and contents of the pack Duzallo 300 mg/200 mg film-coated tablets are orange and slightly brownish oblong tablets and engraved with “LES200” and “ALO300” on one side. 
Duzallo 300 mg/200 mg filmsko obložene tablete so bledo rožnate, podolgovate tablete in imajo na eni strani vgravirana napisa »LES200« in »ALO300«.
Rash and skin symptoms 
Izpuščaj in spremembe na koži
Each Duzallo 300 mg / 200 mg film-coated tablet contains 300 mg of allopurinol and 200 mg of lesinurad. 
Ena filmsko obložena tableta zdravila Duzallo 300 mg/200 mg vsebuje 200 mg alopurinola in 200 mg lesinurada.
Each Duzallo 200 mg / 200 mg film-coated tablet contains 200 mg of allopurinol and 200 mg of lesinurad. 
Ena filmsko obložena tableta zdravila Duzallo 200 mg/200 mg vsebuje 200 mg alopurinola in 200 mg lesinurada.
Duzallo contains lactose 
Zdravilo Duzallo vsebuje laktozo
Pale pink oblong film-coated tablets with 7 x 17 mm in size. 
Bledo rožnate, podolgovate filmsko obložene tablete velikosti 7 x 17 mm. Filmsko obložene tablete imajo na eni strani vgravirana napisa »LES200« in »ALO200«.
Timepoint 
Čas
Reproductive system and breast disorders 
Infekcijske in parazitske bolezni gripa furunkel
Orange and slightly brownish oblong film-coated tablets with 8 x 19 mm in size. 
Oranžne in rahlo rjavkaste podolgovate filmsko obložene tablete velikosti 8 x 19 mm. Filmsko obložene tablete imajo na eni strani vgravirana napisa »LES200« in »ALO300«.
Fertility 
Citostatiki
Each film-coated tablet contains 300 mg allopurinol and 200 mg lesinurad 
Ena filmsko obložena tableta vsebuje 300 mg alopurinola in 200 mg lesinurada
Consistent serum uric acid lowering was observed in patients who were receiving thiazide diuretics in the placebo-controlled clinical studies in combination with allopurinol. 
V kliničnih študijah kombinacije z alopurinolom, nadzorovanih s placebom, so opažali dosledno znižanje sečne kisline pri bolnikih, ki so jemali tiazidne diuretike.
Duzallo 300 mg / 200 mg film-coated tablets allopurinol/lesinurad 
Duzallo 300 mg/200 mg filmsko obložene tablete alopurinol/lesinurad
Each film-coated tablet contains 200 mg allopurinol and 200 mg lesinurad 
Ena filmsko obložena tableta vsebuje 200 mg alopurinola in 200 mg lesinurada
Duzallo 200 mg / 200 mg film-coated tablets allopurinol/lesinurad 
Duzallo 200 mg/200 mg filmsko obložene tablete alopurinol/lesinurad
Lesinurad undergoes oxidative metabolism mainly via cytochrome P450 (CYP) 2C9 to intermediate metabolite M3c (not detected in vivo) and is subsequently metabolised by microsomal epoxide hydrolase (mEH) to metabolite M4; there is minimal contribution from CYP1A1, CYP2C19, and CYP3A to the metabolism of lesinurad. 
Lesinurad se presnovi z oksidativno presnovo, predvsem s citokromom P450 (CYP) 2C9, v vmesni presnovek M3c (in vivo ga niso odkrili).
Impaired liver function tests 
Bolezni jeter, žolčnika in žolčevodov moteni testi delovanja jeter hepatitis
Monitor for decreased efficacy when Duzallo is co-administered with a CYP2C9 inducer. 
Če se uporablja zdravilo Duzallo sočasno z induktorjem CYP2C9, je bolnika treba spremljati glede zmanjšane učinkovitosti.
A possible interaction should be taken into account when a patient on oral anticoagulants is given Duzallo. 
Če prejme bolnik na peroralnih antikoagulantih zdravilo Duzallo, moramo upoštevati možnost medsebojnega delovanja.
Each film-coated tablet contains 200 mg of allopurinol and 200 mg of lesinurad. 
Ena filmsko obložena tableta vsebuje 200 mg alopurinola in 200 mg lesinurada.
Each film-coated tablet contains 300 mg of allopurinol and 200 mg of lesinurad. 
Ena filmsko obložena tableta vsebuje 300 mg alopurinola in 200 mg lesinurada.
The active substances are allopurinol and lesinurad. 
Učinkovini sta alopurinol in lesinurad.
Impaction of uric acid renal stones 
Zagozditev ledvičnih kamnov iz sečne kisline
This summary was last updated in November 2013. 
Povzetek je bil nazadnje posodobljen novembra 2013.
Any contaminated clothes should be removed. 
Vsa kontaminirana oblačila je treba odstraniti.
A number of laboratory studies and field trials in various countries were performed. 
Izvedene so bile številne laboratorijske študije in terenski preskusi v različnih državah.
The European Commission granted a marketing authorisation valid throughout the European Union, for Zolvix on 4 November 2009. 
Evropska komisija je dovoljenje za promet z zdravilom Zolvix, veljavno po vsej Evropski uniji, odobrila dne 4. novembra 2009.
This causes paralysis and death of the worms. 
To povzroči paralizo in odmrtje glist.
Users who are administering this medicine to sheep should wear protective gloves. 
Osebe, ki dajejo ovcam zdravilo, morajo nositi zaščitne rokavice.
Two main studies were carried out, one in Europe and one in New Zealand, in sheep suffering from a range of nematode infections. 
Opravljeni sta bili dve glavni študiji, ena v Evropi in ena na Novi Zelandiji, pri ovcah s številnimi okužbami z glistami.
Other information about Zolvix: 
Druge informacije o zdravilu Zolvix:
The effectiveness of Zolvix has not been established in sheep weighing less than 10 kg and safety has not been established in sheep weighing less than 10 kg or under two weeks of age. 
Učinkovitost zdravila Zolvix ni bila dokazana pri ovcah, ki tehtajo manj kot 10 kg, njegova varnost pa ni bila dokazana pri ovcah, ki tehtajo manj kot 10 kg ali so stare manj kot dva tedna.
Zolvix is available as an oral solution (25 mg/ml). 
Na voljo je kot peroralna raztopina (25 mg/ml).
Zolvix is given as a single dose of 2.5 mg per kilogram bodyweight. 
Zdravilo Zolvix se daje v enkratnem odmerku 2,5 mg na kilogram telesne mase.
The withdrawal period for sheep for meat and offal is seven days. 
Obdobje karence pri ovcah za meso in drobovino je sedem dni.
The oral solution is given directly on the back of the tongue. 
Peroralna raztopina se daje neposredno na koren jezika.
To help delay the development of resistance, users are advised to check the success of the treatment by examining the sheep's clinical appearance, or by testing whether any parasite eggs can be found in the faeces. 
Za podaljšanje časa do razvoja odpornosti se uporabnikom priporoča, da preverijo uspešnost zdravljenja s pregledovanjem kliničnih znakov ovc ali s preverjanjem, če so v iztrebkih prisotna jajčeca zajedavcev.
Zolvix is used for the treatment and control of worm infections of the gut and associated diseases in sheep. 
Zdravilo Zolvix se uporablja za zdravljenje in nadzor črevesnih zajedavskih okužb in z njimi povezanih bolezni pri ovcah.
What benefit has Zolvix shown during the studies? 
Kakšne koristi je zdravilo Zolvix izkazalo med študijami?
The amount to use is calculated based on the weight of the sheep. 
Odmerek se izračuna na podlagi telesne mase ovce.
The CVMP concluded that the benefits of Zolvix exceed the risks for the approved indications and recommended that Zolvix be given a marketing authorisation. 
CVMP je zaključil, da so koristi zdravila Zolvix večje od z njim povezanih tveganj, kadar se uporablja za odobrene indikacije, in priporočil, da se zanj odobri dovoljenje za promet.
Helminths, also known as nematodes, are worm-like parasites that live in the gut of animals. 
Helminti, znani tudi kot gliste, so glistam podobni zajedavci, ki živijo v črevesju živali.
The studies showed that Zolvix is effective against infections of all of the major gastrointestinal nematodes, including effectiveness against strains of parasites resistant to the currently available broad-spectrum anthelmintics. 
Študije so pokazale, da je zdravilo Zolvix učinkovito proti okužbam vseh pomembnejših želodčnočrevesnih glist, vključno s sevi zajedavcev, ki so odporni na trenutno razpoložljive širokospektralne antihelmintike.
Zolvix is a medicine that contains the active substance monepantel. 
Zolvix je zdravilo, ki vsebuje zdravilno učinkovino monepantel.
What is the risk associated with Zolvix? 
Kakšna tveganja so povezana z zdravilom Zolvix?
Zolvix is not authorised for use in lactating animals producing milk for human consumption. 
Zdravilo Zolvix ni odobreno za uporabo pri živalih v laktaciji, katerih mleko je namenjeno prehrani ljudi.
Monepantel blocks part of a receptor, the nicotinic acetylcholine receptor, that is specific to the nematodes. 
Monepantel zavira del receptorja, nikotinski acetilholinski receptor, ki je značilen za gliste.
Why has Zolvix been approved? 
Zakaj je bilo zdravilo Zolvix odobreno?
In case of accidental spillage onto skin or into eyes, the area should be washed immediately with water. 
Če pride do nenamernega razlitja po koži ali če zdravilo pride v stik z očmi, izpostavljene dele takoj izperite z vodo.
In case of accidental ingestion medical advice should be sought immediately and the package leaflet or the label shown to the doctor. 
V primeru nenamernega zaužitja se takoj posvetujte z zdravnikom in mu pokažite navodilo za uporabo ali ovojnino.
Zolvix is effective against a wide range of worm species. 
Zdravilo Zolvix je učinkovito proti številnim vrstam zajedavcev.
Monepantel is effective against nematodes resistant to other anthelmintics. 
Monepantel je učinkovit pri glistah, ki so odporne na druge antihelmintike.
What is Zolvix used for? 
Za kaj se zdravilo Zolvix uporablja?
How has Zolvix been studied? 
Kako je bilo zdravilo Zolvix raziskano?
The New Zealand study and some additional studies compared the effectiveness of Zolvix to other anthelmintics. 
V študiji na Novi Zelandiji in nekaterih dodatnih študijah so primerjali učinkovitost zdravila Zolvix z drugimi antihelmintiki Učinkovitost zdravila Zolvix so v študijah merili s prisotnostjo jajčec zajedavcev v ovčjih iztrebkih ob različnih trenutkih med preskusi.
How does Zolvix work? 
Kako zdravilo Zolvix deluje?
The user must not eat, drink or smoke whilst handling the product and hands and exposed skin should be washed after handling the product. 
Uporabnik med rokovanjem z zdravilom ne sme jesti, piti ali kaditi.
Monepantel, is an anthelmintic, a substance that is active against helminths. 
Monepantel je antihelmintik, tj. snov, ki učinkuje proti helmintom.
What is Zolvix? 
Kaj je zdravilo Zolvix?
CONCLUSIONS ON THE GRANTING OF THE CONDITIONAL MARKETING AUTHORISATION PRESENTED BY THE EUROPEAN MEDICINES AGENCY 
PRILOGA IV SKLEPNE UGOTOVITVE O PRIDOBITVI POGOJNEGA DOVOLJENJA ZA PROMET Z ZDRAVILOM, KI JIH JE PREDSTAVILA EVROPSKA AGENCIJA ZA ZDRAVILA
ATC vet code: QP54AB52. 
Oznaka ATC vet: QP54AB52.
The tablets should not be divided. 
Tablet se ne sme deliti.
The use in these animals is not recommended. 
Uporaba pri teh živalih ni priporočljiva.
If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth. 
Če pes tablete ne vzame prostovoljno, mu jo lahko daste tudi s hrano ali direktno v gobec.
However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. 
Vendar je pri teh občutljivih pasmah (ki lahko vključujejo, toda niso nujno omejene na kolije in sorodne pasme) treba strogo upoštevati priporočeni odmerek.
Therefore, the use of this product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species in order to limit the possibility of a future selection for resistance. 
Zato bi morala uporaba tega zdravila temeljiti na oceni vsakega posameznega primera in na lokalnih epidemioloških podatkih o trenutni občutljivosti ciljnih vrst, da se omeji možnost nadaljnje selekcije glede odpornosti.
Treatment schedule: 
Shema zdravljenja:
Each tablet strength is available in pack sizes of 1, 3 or 6 tablets. 
Tablete posamezne jakosti so na voljo v pakiranjih po 1, 3 ali 6 tablet.
Parasite resistance to any particular class of parasiticides may develop following the frequent, repeated use of a product of that class. 
Odpornost parazitov na kateri koli razred antiparazitika se lahko razvije po pogosti, ponavljajoči se uporabi zdravila tistega razreda.
The treatment schedule should be based on veterinary diagnosis, the local epidemiological situation and/or the epidemiological situation of other areas the dog has visited or is going to visit. 
Shema zdravljenja mora temeljiti na veterinarski diagnozi, lokalni epidemiološki situaciji oziroma epidemiološki situaciji na drugih območjih, ki jih je ali jih bo pes obiskal.
However, accidental administration to dogs infected with adult heartworms should not pose safety concerns. 
Vendar nenamerno dajanje zdravila psom, okuženih z odraslimi srčnimi glistami, ne bi smelo predstavljati pomislekov glede varnosti.
Dogs in areas endemic for heartworm (or those which have travelled to endemic areas) may be infected with adult heartworms. 
Psi na območjih, ki so endemična za srčne gliste (ali tisti, ki so potovali na endemična območja), so lahko okuženi z odraslimi srčnimi glistami.
For dogs with, or at risk from, mixed external and internal parasitic infestations. 
Za pse, ki imajo oziroma so izpostavljeni tveganju mešanih zunanjih in notranjih parazitskih infestacij.
To prevent children from accessing the product, only one chewable tablet at a time should be removed from the blister pack and only when required. 
Da bi preprečili otrokom dostop do zdravila, se mora iz pretisnega omota vzeti le ena žvečljiva tableta naenkrat in samo kadar je to potrebno.
Method of administration Tablets can be administered with or without food. 
Način uporabe Tablete lahko dajemo s hrano ali brez nje.
This results in flaccid paralysis and eventual death of parasites exposed to the drug. 
Posledica tega je flakcidna paraliza in posledično smrt parazitov izpostavljenih zdravilu.
Appropriate combination of tablets 
Primerna kombinacija tablet
Ticks and fleas need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious parasite-borne diseases cannot be excluded. 
Klopi in bolhe se morajo začeti hraniti na gostitelju, da so izpostavljeni sarolanerju, zato prenos infekcijskih bolezni, ki so prenosljive s paraziti, ni izključen.
Pyrantel embonate is poorly absorbed and the absorbed portion has a tmax of 1.5 hours and half-life of 7.7 hours. 
Pirantelijev embonat se slabo absorbira in absorbirani del ima tmax 1,5 ure ter razpolovno dobo 7,7 ur.
Colorants: Sunset Yellow FCF (E110), Allura Red (E129), Indigo Carmine (E132). 
Barvila: sončno rumeno FCF (E110), allura rdeče (E129), indigotin (E132).
Moxidectin is a second-generation macrocyclic lactone of the milbemycin family. 
Moksidektin je makrociklični lakton druge generacije iz skupine milbemicina.
Date of first authorisation: 17/09/2019 
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum pridobitve dovoljenja za promet: 17/09/2019
Pyrantel is eliminated through faeces and the small absorbed portion is eliminated mainly via urine. 
Pirantel se izloča z blatom in majhen absorbirani del se v glavnem izloči z urinom.
Macrocyclic lactones including moxidectin have been shown to be substrates for p-glycoprotein. 
Pokazalo se je, da so makrociklični laktoni, vključno z moksidektinom substrati za p-glikoprotein.
The prandial state of the dogs does not affect the extent of absorption of sarolaner and moxidectin. 
Hranjenje psov ne vpliva na obseg absorpcije sarolanerja in moksidektina.
In this fixed combination, moxidectin and pyrantel provide complementary anthelmintic efficacy through distinct mechanisms of action. 
V tej fiksni kombinaciji moksidektin in pirantel zagotavljata dodatno antihelmintično učinkovitost z drugačnimi mehanizmi delovanja.
Manufacturer responsible for batch release: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt 68723 Baden-Wuerttemberg GERMANY 
Proizvajalec odgovoren za sproščanje serij: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt 68723 Baden-Wuerttemberg NEMČIJA
In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 1.25 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian. 
Zaradi pomanjkanja podatkov, mora zdravljenje mladičev, mlajših od 8 tednov starosti oziroma psov, lažjih od 1,25 kg temeljiti na oceni razmerja korist/tveganje odgovornega veterinarja.
To minimise the risk of resistance selection, it is recommended that dogs should be checked for both circulating antigens and blood microfilariae at the beginning of each season of preventative treatment. 
Za zmanjševanje tveganja za selekcijo glede odpornosti, se priporoča, da pse pred pričetkom vsakega obdobja preventivnega zdravljenja testira tako za antigene kot za mikrofilarije v krvnem obtoku.
Pyrantel is a nicotinic acetylcholine (ACh) channel receptor (nAChR) agonist. 
Pirantel je nikotin acetilholinski (ACh) agonist kanalskega receptorja (nAChR).
In the absence of the risk of mixed co-infestation, a narrower spectrum parasiticide should be used. 
Če ne obstaja tveganje za hkratno mešano infestacijo, je treba uporabiti ožji spekter antiparazitika.
EU/2/19/243/001-018 
ŠTEVILKA(E) DOVOLJENJ(A) ZA PROMET EU/2/19/243/001-018
Maintenance of the efficacy of macrocyclic lactones is critical for Dirofilaria immitis control. 
Vzdrževanje učinkovitosti makrocikličnih laktonov je ključnega pomena za nadzor okuženosti z Dirofilaria immitis.
pyrantel (as embonate) (mg) 
pirantel (kot embonat) (mg)
It is recommended that heartworm prevention treatment should be continued until at least 1 month after the last exposure to mosquitoes. 
Priporočljivo je, da se s preventivnim zdravljenjem srčnih glist nadaljuje vsaj 1 mesec po zadnji izpostavljenosti živali komarjem.
This veterinary medicinal product is not effective against adult D. immitis. 
To zdravilo za uporabo v veterinarski medicini ne učinkuje na odraslo obliko D. immitis.
The accidental ingestion of the product may potentially result in adverse effects, such as transient excitatory neurological signs. 
Nenamerno zaužitje zdravila lahko povzroči neželene učinke, kot so prehodni ekscitacijski nevrološki znaki.
In particular, both active substances contribute to the overall efficacy against the gastrointestinal nematodes Ancylostoma caninum and Toxocara canis. 
Predvsem obe učinkovini prispevata k splošni učinkovitosti proti gastrointestinalnim nematodom Ancylostoma caninum in Toxocara canis.
When the product replaces another lungworm or heartworm preventive product, the first dose of the product should be given within a month of the last dose of the former veterinary medicinal product. 
Kadar z zdravilom zamenjamo drugo preventivno zdravilo proti pljučni ali srčni glistavosti, moramo prvi odmerek zdravila dati v obdobju znotraj enega meseca po zadnjem dajanju prejšnjega zdravila za uporabo v veterinarski medicini.
The veterinary medicinal product kills newly emerged fleas on the dog before they can lay eggs and therefore it prevents environmental flea contamination in areas to which the dog has access. 
To zdravilo za uporabo v veterinarski medicini ubije bolhe, ki pridejo na psa po dajanju zdravila, preden bi lahko izlegle jajčeca in tako prepreči onesnaženje okolja z bolhami na področjih, do katerih ima pes dostop.
Simparica Trio chewable tablets sarolaner (mg) 
Simparica Trio žvečljive tablete sarolaner (mg)
Fleas on the animal prior to administration are killed within 8 hours. 
Bolhe, ki so že na živali pred dajanjem zdravila so ubite v 8 urah.
− For the prevention of heartworm disease (Dirofilaria immitis); 
− Za preprečevanje obolenja srčne glistavosti (Dirofilaria immitis);