natgillin/translations-raw huggingface dataset:
Pregnant women and women of child-bearing potential should not administer Meloxidolor as meloxicam may be harmful for the foetus and unborn child. 
Noseče ženske in ženske, ki bi lahko zanosile, naj zdravila Meloxidolor ne dajejo, ker je meloksikam lahko škodljiv za plod ali nerojenega otroka.
It is available as a solution for injection (5 mg/ml, 20 mg/ml and 40 mg/ml). 
Na voljo je kot raztopina za injiciranje (5 mg/ml, 20 mg/ml in 40 mg/ml).
What benefit has Meloxidolor shown during the studies? 
Kakšne koristi je zdravilo Meloxidolor izkazalo med študijami?
It is also the time allowed after administration of the medicine before the milk can be used for human consumption. 
To je tudi čas, ki mora preteči po dajanju zdravila, preden se lahko mleko uporabi za prehrano ljudi.
In horses, a temporary swelling at the injection site can occur but resolves without intervention. 
Pri konjih se lahko na mestu vboda pojavi začasna oteklina, ki mine brez intervencije.
It must not be used in animals which are hypersensitive (allergic) to the active substance or to any of the other ingredients. 
Zdravilo se ne sme uporabljati pri živalih, ki so preobčutljive za (alergične na) zdravilno učinkovino ali katero koli drugo sestavino zdravila.
Meloxidolor meloxicam 
Meloxidolor meloksikam
Meloxicam acts by blocking an enzyme called cyclo-oxygenase which is involved in the production of prostaglandins. 
Meloksikam zavira encime, imenovane ciklooksigenaza, ki sodelujejo pri nastajanju prostaglandinov.
In very rare cases, potentially serious or fatal anaphylactoid reactions (similar to severe allergic reactions) may occur following administration of the solution for injection and should be treated symptomatically. 
Zelo redko se lahko po dajanju raztopine za injiciranje pojavijo potencialno resne ali smrtno nevarne anafilaktoidne reakcije (podobne hudim alergičnim reakcijam), ki jih je treba zdraviti simptomatsko.
The product is not authorised for use in horses producing milk for human consumption. 
Zdravilo ni dovoljeno za uporabo pri konjih v laktaciji, katerih mleko je namenjeno prehrani ljudi.
This means that Meloxidolor is similar to a ‘reference veterinary medicine' containing the same active substance, but it is also available at a higher strength. 
To pomeni, da je podobno referenčnemu zdravilu za uporabo v veterinarski medicini, saj vsebuje enako zdravilno učinkovino, vendar je na voljo tudi v večji jakosti.
For intravenous use no studies in animals were needed as Meloxidolor contains the same active substance as the reference medicine Metacam. 
Za intravenozno uporabo pri živalih niso bile potrebne nobene študije, saj zdravilo Meloxidolor vsebuje enako zdravilno učinkovino kot referenčno zdravilo Metacam.
As prostaglandins are substances that trigger inflammation, pain, exudation (fluid that leaks out of blood vessels during an inflammation) and fever, meloxicam reduces these signs of disease. 
Ker so prostaglandini snovi, ki sprožajo vnetje, bolečino, izločanje tekočine (ki med vnetjem uhaja iz krvnih žil) in zvišano telesno temperaturo, meloksikam te bolezenske znake zmanjšuje.
Therefore the CVMP's view was that, as for Metacam, Meloxidolor's benefits are greater than its risks when used for the approved indications and the Committee recommended that Meloxidolor be given a marketing authorisation. 
Zato je menil, da so njegove koristi, kot pri zdravilu Metacam, večje od z njim povezanih tveganj pri uporabi za odobrene indikacije, in priporočil, da se zanj odobri dovoljenje za promet.
What is the risk associated with Meloxidolor? 
Kakšna tveganja so povezana z zdravilom Meloxidolor?
Meloxidolor contains meloxicam, which belongs to a class of medicines called non-steroidal antiinflammatory drugs (NSAIDs). 
Zdravilo Meloxidolor vsebuje meloksikam, ki spada v skupino nesteroidnih protivnetnih zdravil (NSAID).
Meloxidolor must not be used in dogs, in cats or horses less than six weeks of age, in cattle less than one week of age when used in the treatment of diarrhoea or in pigs less than two days old. 
Zdravilo Meloxidolor se ne sme uporabljati pri psih, mačkah ali konjih, mlajših od šest tednov, pri govedu, mlajšem od enega tedna, za zdravljenje driske, ali pri prašičih, mlajših od dveh dni.
It can be used in combination with oral re-hydration therapy for diarrhoea (medicines given by mouth to restore water levels in the body) in calves of over one week of age and in young, non-lactating cattle. 
V kombinaciji s peroralnim rehidracijskim zdravljenjem driske (zdravili, ki se dajejo v usta za obnovitev ravni vode v telesu) se lahko uporablja pri teletih, starejših od enega tedna, in mladem govedu, ki ni v obdobju laktacije.
Meloxidolor is a medicine that contains the active substance meloxicam. 
Meloxidolor je zdravilo, ki vsebuje zdravilno učinkovino meloksikam.
For subcutaneous and intramuscular use no studies were need for the 5 mg/ml and 20 mg/ml strengths as they contain the same concentration of active substance and have a similar composition to the reference product Metacam. 
Za podkožno in intramuskularno uporabo za jakosti 5 mg/ml in 20 mg/ml niso bile potrebne nobene študije, saj vsebujejo enako koncentracijo zdravilne učinkovine in imajo podobno sestavo kot referenčno zdravilo Metacam.
Meloxidolor is a 'generic'. 
Meloxidolor je generično zdravilo.
Meloxidolor must not be used in animals with liver, heart or kidney problems, bleeding disorders, or suffering from irritation or ulcers of the digestive tract. 
Zdravila Meloxidolor ni dovoljeno uporabljati pri živalih s težavami z jetri, srcem ali ledvicami, krvavitvenimi motnjami ali pri živalih s težavami z draženjem ali razjedami prebavnega trakta.
Why has Meloxidolor been approved? 
Zakaj je bilo zdravilo Meloxidolor odobreno?
While the reference medicine, Metacam, is available as 5 mg/ml and 20 mg/ml solutions for injection, Meloxidolor is also available as a 40 mg/ml solution for injection. 
Medtem ko je referenčno zdravilo Metacam na voljo kot raztopina za injiciranje v jakosti 5 mg/ml in 20 mg/ml, je zdravilo Meloxidolor na voljo tudi kot raztopina za injiciranje v jakosti 40 mg/ml.
The 5 mg/ml solution for injection can also be used for the relief of post-operative pain associated with minor soft tissue surgery such as castration (surgical removal of the testicles) and the 20 mg/ml solution for injection can be used together with appropriate antibiotic therapy for the treatment of diseases that occur after farrowing (giving birth) such as puerperal septicaemia (bacteria present in blood) and toxaemia (a toxic state) (mastitis-metritis-agalactia syndrome). 
Raztopina za injiciranje v jakosti 5 mg/ml se lahko uporablja tudi za lajšanje postoperativnih bolečin, povezanih z manjšimi operacijami mehkega tkiva (kirurško odstranitvijo mod), raztopina za injiciranje v jakosti 20 mg/ml pa se lahko ob ustreznem antibiotičnem zdravljenju uporablja za zdravljenje bolezni, ki nastanejo po prasitvi (kotitvi), na primer puerperalna septikemija (bakterija, ki je prisotna v krvi) in toksemija (toksično stanje) (sindrom mastitisa, metritisa in agalaktije).
Meloxidolor should not be used in pregnant or lactating dogs, cats and horses, but it can be used during pregnancy and lactation for cattle and pigs. 
Zdravilo Meloxidolor se ne sme uporabljati pri psih, mačkah ali konjih v obdobju brejosti ali laktacije, lahko pa se v obdobju brejosti ali laktacije uporablja pri govedu in prašičih.
Meloxidolor solution for injection (5 mg/ml and 20 mg/ml) is used in pigs to reduce the symptoms of lameness (inability to walk normally) and inflammation in non-infectious locomotor disorders (diseases that affect the ability to move). 
Meloxidolor raztopina za injiciranje (5 mg/ml in 20 mg/ml) se uporablja pri prašičih za ublažitev simptomov ohromelosti (nezmožnosti normalne hoje) in vnetja pri neinfekcijskih lokomotornih motnjah (boleznih, ki vplivajo na sposobnost premikanja).
Meloxidolor solution for injection (5 mg/ml) can be used to relieve inflammation and pain in dogs following surgery involving the bones or soft tissue (tissue just below the skin), and in cats following ovariohysterectomy (spaying) and minor soft tissue surgery. 
Meloxidolor raztopina za injiciranje (5 mg/ml) se lahko uporablja pri psih za lajšanje vnetja in bolečin po operacijah kosti ali mehkega tkiva (tkivo tik pod kožo) ter pri mačkah po ovariohisterektomiji (steriliziranju) in manjših operacijah mehkega tkiva.
Meloxidolor solution for injection (20 mg/ml and 40 mg/ml) is used in horses to relieve colic (abdominal pain) and the inflammation and pain in musculo-skeletal disorders. 
Meloxidolor raztopina za injiciranje (20 mg/ml in 40 mg/ml) se uporablja pri konjih za lajšanje kolik (bolečin v trebuhu) ter vnetja in bolečin pri kostno-mišično obolenjih.
Meloxidolor solution for injection (5 mg/ml, 20 mg/ml and 40 mg/ml) is used in cattle, together with appropriate antibiotic therapy, to reduce signs of disease in acute respiratory infections (infection of the lungs and airways). 
Meloxidolor raztopina za injiciranje (5 mg/ml, 20 mg/ml in 40 mg/ml) se pri govedu ob ustreznem antibiotičnem zdravljenju uporablja za umirjanje znakov bolezni pri akutnih okužbah dihal (okužbah pljuč in dihalnih poti).
How has Meloxidolor been studied? 
Kako je bilo zdravilo Meloxidolor raziskano?
What is Meloxidolor used for? 
Za kaj se zdravilo Meloxidolor uporablja?
How does Meloxidolor work? 
Kako zdravilo Meloxidolor deluje?
Side effects sometimes seen with other NSAIDs, such as loss of appetite, vomiting, diarrhoea, blood appearing in the stools, renal (kidney) failure and apathy (lack of vitality) are occasionally seen with Meloxidolor in dogs and cats. 
Pri uporabi zdravila Meloxidolor pri prsih in mačkah se občasno pojavijo neželeni učinki, ki so včasih opaženi pri drugih nesteroidnih protivnetnih zdravilih, kot so izguba teka, bruhanje, driska, kri v blatu, ledvična odpoved in apatija (pomanjkanje vitalnosti).
What is Meloxidolor? 
Kaj je zdravilo Meloxidolor?
A slight temporary swelling at the injection site following injection under the skin was observed in cattle and pigs. 
Pri govedu in prašičih je bila opažena blaga začasna oteklina na mestu vboda pod kožo.
The 20 mg/ml and 40/mg/ml solutions for injection are also used in combination with antibiotic therapy to treat acute mastitis (inflammation of the udder). 
Raztopina za injiciranje v jakosti 20 mg/ml in 40 mg/ml se lahko v kombinaciji z antibiotičnim zdravljenjem prav tako uporablja za zdravljenje akutnega mastitisa (vnetja vimena).
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 27 November 2015 
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve: 27. november 2015
− infection including sepsis 
− okužba, vključno s sepso
The results of these analyses of efficacy are summarised in the table below. 
Izsledki teh analiz učinkovitosti so povzeti v spodnji preglednici.
− thirst and increased water consumption 
− žeja in povečano pitje vode
Any diarrhoea requiring hospitalisation (irrespective of grade) or grade 3 or 4 diarrhoea 
Kakršnakoli diareja, ki potrebuje hospitalizacijo (ne glede na stopnjo) ali diareja stopnje 3 ali 4
PFS data were partially confirmed by an independent review (400/1,725 patients were randomly selected for review). 
PBN podatki so bili delno potrjeni z neodvisnim pregledom (400/1725 bolnikov je bilo naključno izbranih za pregled).
Gently swirl each vial until the powder is completely dissolved. 
Vsako vialo narahlo sukajte, dokler se prašek popolnoma ne raztopi.
− if you are allergic to pemetrexed or any of the other ingredients of this medicine (listed in section 6). 
− če ste alergični na pemetreksed ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
− increased skin pigmentation 
− povečana pigmentiranost kože
Further dilution is required. 
Potrebno je dodatno redčenje.
22880 Wedel 
22880 Wedel Nemčija
The pH of the reconstituted solution is between 6.6 and 7.8. 
Vrednost pH pripravljene raztopine je med 6,6 in 7,8.
Survival Time (months) 
Čas preživetja (meseci)
Do not use this medicine after the expiry date which is stated on the label and carton after EXP. 
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki in škatli poleg oznake EXP.
< 1/100), Rare (≥ 1/10,000 to < 1/1,000), Very rare (< 1/10,000) and not known (cannot be estimated from available data). 
do < 1/100), redko (≥ 1/10.000 do < 1/1.000), zelo redko (< 1/10.000) in neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov).
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness 
V vsaki skupini pogostnosti so neželeni učinki navedeni po padajoči resnosti.
Based on the planned date of your infusion of Pemetrexed medac and/or on the status of your kidney function, your doctor needs to advise you on which medicines you can take and when you can take them. 
Na podlagi načrtovanega datuma vaše infuzije zdravila Pemetreksed medac in/ali glede na delovanje vaših ledvic vam mora zdravnik svetovati, katera zdravila lahko jemljete in kdaj jih lahko jemljete.
The European Medicines Agency has waived the obligation to submit the results of studies with Pemetrexed in all subsets of the paediatric population in the granted indications (see section 4.2). 
Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij s pemetreksedom za vse podskupine pediatrične populacije za odobrene indikacije (glejte poglavje 4.2).
− low white blood cells 
− nizko število belih krvnih celic
It is a white to light yellow powder. 
Je bel do svetlo rumen prašek.
Brnĕnská 32/čp. 
Brnenská 32/čp.
Calculate the dose and the number of Pemetrexed medac vials needed. 
Izračunajte odmerek in število potrebnih vial zdravila Pemetreksed medac.
If you are unsure, ask your doctor or pharmacist if any of your medicines are NSAIDs. 
Če niste prepričani, vprašajte zdravnika ali farmacevta, ali je katero od vaših zdravil vrste NSAID.
If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would not be longer than 24 hours at 2 °C to 8 °C. 
Če zdravila, pripravljenega za uporabo, ne uporabimo takoj, je za čase shranjevanja in pogoje pred uporabo odgovoren uporabnik, in naj bi ne presegali 24 ur pri 2 do 8 °C.
100 % of previous dose 
100 % predhodnega odmerka
Driving and using machines Pemetrexed medac may make you feel tired. 
Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Pemetreksed medac lahko povzroči, da se boste počutili utrujene.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. 
Nosečnost Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo.
− increased urine output 
− povečano izločanje urina
MARKETING AUTHORISATION NUMBER(S) EU/1/15/1038/001 Pemetrexed medac 100 mg EU/1/15/1038/002 Pemetrexed medac 500 mg EU/1/15/1038/003 Pemetrexed medac 1,000 mg 
EU/1/15/1038/001 Pemetreksed medac 100 mg EU/1/15/1038/002 Pemetreksed medac 500 mg EU/1/15/1038/003 Pemetreksed medac 1000 mg
If you are also receiving cisplatin, your doctor will make sure that you are properly hydrated and receive appropriate treatment before and after receiving cisplatin to prevent vomiting. 
Če prejemate tudi cisplatin, bo zdravnik zagotovil, da ste ustrezno hidrirani ter da pred prejemanjem cisplatina in po njem prejemate ustrezno zdravljenje za preprečevanje bruhanja;
When using Pemetrexed medac in combination with cisplatin The doctor or hospital pharmacist will work out the dose you need based on your height and weight. 
Kadar uporabljamo zdravilo Pemetreksed medac v kombinaciji s cisplatinom Zdravnik ali bolnišnični farmacevt bo določil odmerek, ki ga potrebujete, na podlagi vaše telesne višine in mase.
Reconstituted and infusion solutions: The product should be used immediately. 
Rekonstituirane raztopine in raztopine za infundiranje: zdravilo moramo uporabiti nemudoma.
In particular, tell your doctor if you are using medicines for pain or inflammation (swelling), such as medicines called “nonsteroidal anti-inflammatory drugs” (NSAIDs), including medicines purchased without a doctor's prescription (such as ibuprofen). 
Še zlasti je pomembno, da poveste svojemu zdravniku, če jemljete zdravila proti bolečinam ali vnetju (oteklinam), denimo zdravila, imenovana »nesteroidna protivnetna zdravila« (NSAID), vključno z zdravili, ki ste jih dobili brez recepta (npr. ibuprofen).
If concomitant administration of NSAIDs is necessary, patients should be monitored closely for toxicity, especially myelosuppression and gastrointestinal toxicity. 
Če je sočasno dajanje NSAID-ov potrebno, je pri bolnikih potrebno skrbno spremljati toksičnost, predvsem mielosupresijo in gastrointestinalno toksičnost.
− you have heart disease or a history of heart disease. 
− če imate bolezen srca ali če ste v preteklosti imeli bolezen srca;
Your doctor will discuss with you the potential risk of taking Pemetrexed medac during pregnancy. 
Zdravnikom se boste pogovorili o možnem tveganju pri prejemanju zdravila Pemetreksed medac v času nosečnosti.
Patients must also receive an intramuscular injection of vitamin B12 (1,000 µg) in the week preceding the first dose of pemetrexed and once every three cycles thereafter. 
Bolniki morajo prejeti tudi intramuskularno injekcijo vitamina B12 (1000 µg) v tednu pred prvim odmerkom pemetrekseda in enkrat vsake tri cikluse zatem.
Each pack consists of one vial containing 100 , 500 or 1,000 mg of pemetrexed. 
Vsako pakiranje vsebuje eno vialo s 100, 500 ali 1000 mg pemetrekseda.
− taste change 
− sprememba okusa
Name and address of the manufacturers responsible for batch release Synthon Hispania, S.L. 
Ime in naslov izdelovalca (izdelovalcev), odgovornega (odgovornih) za sproščanje serij Synthon Hispania, S.L.
− loss of appetite 
− slabost − izguba apetita
Discuss with your doctor when it is safe to restart breast-feeding after finishing your treatment. 
Z zdravnikom se posvetujte, kdaj je po koncu zdravljenja varno ponovno začeti dojiti.
− if you have recently received or are about to receive a vaccine against yellow fever. 
− če ste bili nedavno cepljeni ali boste kmalu cepljeni proti rumeni mrzlici.
There are many sorts of NSAIDs with different durations of activity. 
Obstaja veliko vrst zdravil NSAID z različnimi trajanji delovanja.
Before each infusion you will have samples of your blood taken to evaluate if you have sufficient kidney and liver function and to check that you have enough blood cells to receive Pemetrexed medac. 
Pred vsako infuzijo vam bomo odvzeli vzorce krvi za vrednotenje delovanja vaših ledvic in jeter ter oceno, ali imate dovolj krvnih celic za prejemanje zdravila Pemetreksed medac.
− liver: abnormal blood tests 
− jetra: nenormalne vrednosti krvnih testov
Vitamin supplementation 
Dopolnjevanje vitaminov
− allergic reaction: skin rash / burning or prickling sensation 
− alergijske reakcije: kožni izpuščaji/pekoč ali zbadajoč občutek
Upon recovery patients should be retreated using the guidelines in Tables 1, 2 and 3, which are applicable for Pemetrexed medac used as a single agent or in combination with cisplatin. 
Po okrevanju bolnike ponovno zdravimo z uporabo smernic v Preglednicah 1, 2 in 3, ki veljajo za zdravilo Pemetreksed medac, če ga uporabljamo kot edino učinkovino ali v kombinaciji s cisplatinom.
Of the randomised patients, 44.9 % had a complete/partial response and 51.9 % had a response of stable disease to pemetrexed plus cisplatin induction. 
Izmed naključno izbranih bolnikov jih je 44,9 % doseglo popoln/delen odziv in 51,9 % jih je doseglo odziv stabilne bolezni na indukcijsko terapijo s pemetreksedom in cisplatinom.
Kaplan Meier plots of overall survival by histology 
Kaplan Meierjeva grafa skupnega preživetja glede na histologijo
The resulting solution is clear and ranges in colour from colourless to yellow without adversely affecting product quality. 
Nastala raztopina je bistra, barve v razponu od brezbarvne do rumene ne vplivajo na kakovost izdelka.
− radiation recall (a skin rash like severe sunburn) which can occur on skin that has previously been exposed to radiotherapy, from days to years after the radiation 
− radiacijski izpuščaj (kožni izpuščaj kot pri hudi sončni opeklini), ki se lahko pojavi na koži, ki je bila v preteklosti izpostavljena obsevanju, in sicer od nekaj dni do več let po obsevanju
Concomitant use contraindicated: Yellow fever vaccine: risk of fatal generalised vaccine disease (see section 4.3). 
Kontraindicirana sočasna uporaba: Cepivo proti rumeni mrzlici: tveganje za smrtno generalizirano bolezen po cepljenju (glejte poglavje 4.3).
− fever or infection (common): if you have a temperature of 38 °C or greater, sweating or other signs of infection (since you might have less white blood cells than normal which is very common). 
− Povišana telesna temperatura ali okužba (pogosto): če se pojavi temperatura 38 ºC ali višja, znojenje ali drugi znaki okužbe (ker imate lahko manj belih krvničk kot normalno, kar je zelo pogosto).
Thus, drainage of third space fluid collection prior to pemetrexed treatment should be considered, but may not be necessary. 
Zato je pred zdravljenjem s pemetreksedom vredno premisliti o drenaži tekočine tretjega prostora, čeprav to morda ni potrebno.
• HR (95 % CI) Response (n: qualified for response) 
• RT (95 % IZ) Odziv (n: ustrezen za odziv)
Frequency estimate: Very common (≥ 1/10), Common (≥ 1/100 to < 1/10), Uncommon (≥ 1/1,000 to 
Pogostnosti so določene kot: zelo pogosto (≥ 1/10), pogosto (≥ 1/100 do < 1/10), občasno (≥ 1/1.000
The other ingredients are mannitol, hydrochloric acid and sodium hydroxide, please see section 2 “Pemetrexed medac contains sodium”. 
Druge sestavine zdravila so manitol, klorovodikova kislina in natrijev hidroksid; glejte poglavje 2 »Zdravilo Pemetreksed medac vsebuje natrij«.
The 1 year and 2 year survival rates for patients on pemetrexed were 58 % and 32 % respectively, compared to 45 % and 21 % for patients on placebo. 
sta bili 58 % in 32 %, v primerjavi s 45 % in 21 % pri bolnikih, ki so prejemali placebo.
**** Combined term includes increased serum/blood creatinine, decreased glomerular filtration rate, renal failure and renal/genitourinary - other. 
**** Skupni izraz vključuje povišan kreatinin v serumu/krvi, znižano stopnjo glomerulne filtracije, ledvično odpoved in ledvice/sečila - drugo.
• 95 % CI for median 
• 95 % IZ za mediano
− fast heart rate 
− hiter srčni utrip
− oedema (excess fluid in body tissue, causing swelling) 
− edem (preveč tekočine v telesnih tkivih, kar povzroča oteklino)
− hypernatraemia - increased sodium in blood 
− hipernatriemija - zvišana raven natrija v krvi
Your doctor will prescribe you steroid tablets (equivalent to 4 mg of dexamethasone twice a day) that you will need to take on the day before, on the day of, and the day after Pemetrexed medac treatment. 
Zdravnik vam bo predpisal tablete steroidov (ustrezno 4 mg deksametazona dvakrat dnevno), ki jih boste morali jemati na dan pred zdravljenjem, na dan zdravljenja in na dan po zdravljenju z zdravilom
Treatment with pemetrexed should be discontinued if a patient experiences any haematologic or non-haematologic Grade 3 or 4 toxicity after 2 dose reductions or immediately if Grade 3 or 4 neurotoxicity is observed. 
Zdravljenje s pemetreksedom moramo prekiniti, če bolnik izkusi kakršnokoli hematološko ali nehematološko toksičnost stopnje 3 ali 4 po 2 znižanjih odmerka ali nemudoma, če opazimo nevrološko toksičnost stopnje 3 ali 4.
Men are advised not to father a child during and up to 6 months following treatment with Pemetrexed medac and should therefore use effective contraception during treatment with Pemetrexed medac and for up to 6 months afterwards. 
Moškim odsvetujemo, da bi v času zdravljenja z zdravilom Pemetreksed medac ter do 6 mesecev po zdravljenju s tem zdravilom spočeli otroka, zato naj v času zdravljenja z zdravilom Pemetreksed medac ter do 6 mesecev po zdravljenju s tem zdravilom uporabljajo učinkovito kontracepcijo.