natgillin/translations-raw huggingface dataset:
Both collagenases effectively cleave interstitial collagen but at different sites on the molecule; additionally, they prefer different conformations (triple helical versus denatured or cleaved). 
Obe kolagenazi učinkovito cepita intersticijski kolagen, vendar na različnih mestih molekule; poleg tega pa imata afiniteto do različnih oblik (trojna spirala proti denaturirana ali cepljena).
For further information see “Instructions on how to gently stretch your penis” and “Instructions on how to gently straighten your penis” at the end of the Patient leaflet. 
Za več informacij glejte »Navodila za nežno raztezanje penisa« in »Navodila za nežno ravnanje penisa« na koncu navodila za uporabo.
Orient the needle so that it enters the plaque from the side, NOT downwards or perpendicularly towards the corpora cavernosum. 
Iglo usmerite tako, da v plak vstopi s strani, NE navzdol ali pravokotno na kavernozni telesi.
Your doctor may recommend you perform a series of finger flexion and extension exercises several times a day for several months. 
Zdravnik vam utegne svetovati, da izvajajte serije vaj upogibanja in iztegovanja prstov večkrat dnevno več mesecev.
Because Xiapex is not a substrate for cytochrome P450 or other medicinal product metabolizing enzyme pathways, and because no active metabolites are expected, no metabolism studies have been performed. 
Ker zdravilo Xiapex ni substrat za citokrom P450 ali druge encimske poti, ki presnavljajo zdravila, in ker ne pričakujemo aktivnih presnovkov, študije presnove niso bile izvedene.
The improvement in curvature deformity was numerically similar among patients with baseline deformity from 30 to 60 degrees and those with curvature deformity from 61 to 90 degrees. 
Izboljšanje deformacije ukrivljenosti je bilo v številkah podobno med bolniki z izhodiščno deformacijo od 30 do 60 stopinj in tistimi z deformacijo ukrivljenosti od 61 do 90 stopinj.
There are no known interactions with concomitant use of medicines for erectile dysfunction and Xiapex treatment. 
Ni znanih interakcij pri sočasni uporabi zdravil za erektilno disfunkcijo in zdravilom Xiapex.
The primary endpoint of each study was to evaluate the proportion of patients who achieved a reduction in contracture of the selected primary joint (MP or PIP) to 5° or less of normal, approximately 4 weeks after the last injection of that joint. 
Primarni opazovani dogodek v vsaki študiji je bila ocena deleža bolnikov, ki so dosegli zmanjšanje kontrakture izbranega primarnega sklepa (MP ali PIP) na 5° ali manj od normale, približno 4 tedne po zadnjem injiciranju v ta sklep.
• After each injection of Xiapex, your penis may be wrapped with a bandage. 
• Po vsaki injekciji zdravila Xiapex bodo morda vaš penis povili s povojem.
Administration of Xiapex at greater than recommended doses is expected to be associated with increased local reactions at the site of injection. 
Pričakuje se, da je aplikacija zdravila Xiapex v odmerkih, ki so večji od priporočenih, povezana z povečanim številom lokalnih reakcij na mestu injiciranja.
• One to three days after the second injection of Xiapex in a treatment cycle, you will need to return to your doctor for a manual procedure that will help stretch and help straighten your penis. 
• En do tri dni po drugi injekciji zdravila Xiapex v ciklu zdravljenja se boste morali vrniti k zdravniku za ročni postopek, ki bo pomagal pri raztezanju in ravnanju penisa.
With your other hand, gently bend your penis in the opposite direction of the curve (see Figure 4). 
Z drugo roko nežno upognite penis v smeri nasproti ukrivljenosti (glejte sliko 4).
Class I collagenases (α, β, γ, and η) are the products of the colG gene, they initiate collagen hydrolysis near the amino and carboxy termini of triple helical domains and generate large proteolytic fragments. 
Kolagenaze razreda I (α, β, γ, in η) so produkti gena colG in začnejo hidrolizo kolagena blizu amino in karboksi koncev trojne spirale ter proizvajajo velike proteolitične fragmente.
Mean Penile Curvature Deformity (degrees) (Min-Max) 
Povprečna deformacija ukrivljenosti penisa (stopinje) (min-maks)
If you experience dizziness, numbness or altered sensation, and headache immediately after an injection of Xiapex you must avoid potentially hazardous tasks such as driving or using machines until these effects have passed or until advised by your doctor. 
Če se takoj po takoj po injiciranju zdravila Xiapex pojavijo omotica, odrevenelost ali spremenjeno občutenje in glavobol, se morate izogibati morebitnim nevarnim opravilom, kot je na primer vožnja ali uporaba strojev, dokler ti učinki ne minejo ali dokler vam tega ne svetuje zdravnik.
Through the 5 year follow up period (Table 13), subjects demonstrated an improvement in penile curvature and in PDQ bother compared with the last observed value from the previous phase 3 studies. 
V 5-letnem obdobju spremljanja (preglednica 13) se je pri osebah pokazalo izboljšanje glede ukrivljenosti penisa in težav zaradi PDQ v primerjavi z zadnjo opazovano vrednostjo iz prejšnjih študij 3. faze.
If a cord contracture remains, a passive finger extension procedure will be performed in an attempt to disrupt the cord. 
Če je kontrakturni vozlič še prisoten, bo napravljen postopek pasivnega iztegovanja prstov, da bi poskušali prekiniti vozlič.
Your doctor will carefully select an area where the collagen cord is best accessible and will proceed with the injection into the cord. 
Zdravnik bo skrbno izbral predel, kjer je kolagenski vozlič najlažje dostopen, in bo vanj injiciral zdravilo.
Tell your doctor right away if you have trouble stretching or straightening your penis, or if you have pain or other concerns. 
Zdravniku takoj povejte, če imate težave z raztezanjem ali ravnanjem penisa ali bolečino oziroma druge skrbi.
The Bother domain score is a composite of the following patient-reported items: concern about erection pain, erection appearance, and the impact of Peyronie's disease on intercourse and on frequency of intercourse. 
Rezultat Področja težav je sestavljen iz naslednjih postavk, o katerih poročajo bolniki: skrb zaradi bolečine ob erekciji, izgled erekcije in vpliv Peyroniejeve bolezni na spolni odnos in pogostnost spolnega odnosa.
If two cords of affected joints on the same hand are to be treated during a treatment visit, separate vials and syringes should be used for each reconstitution and injection. 
Če je treba med obiskom za zdravljenje zdraviti dva vozliča prizadetega sklepa istega roke, je treba za vsako rekonstitucijo in injekcijo uporabiti ločeni viali in injekcijski brizgi.
f) Insert and advance the needle transversely through the width of the plaque, towards the opposite side of the plaque without passing completely through it. 
f) Iglo vstavite in potiskajte prečno skozi širino plaka, proti nasprotni strani plaka, a je ne potisnite do konca skozi plak.
Swelling and pain may impair the use of the treated hand in Dupuytren's disease. 
Otekanje in bolečina lahko ovirata uporabo zdravljene roke pri Dupuytrenovi bolezni.
Same Finger, 1 MP, 1 PIP (n=350) 
Isti prst, 1 MP, 1 PIP (n = 350)
The review of data presented in the PSUR for Xiapex, covering the period from 28 February 2018 to 27 February 2019, identified post-marketing and literature case reports of finger necrosis and/or amputation and of finger fractures in patients with Dupuytren's contracture treated with collagenase clostridium histolyticum. 
Pri pregledu podatkov, predstavljenih v oceni PSUR za zdravilo Xiapex, ki pokriva obdobje od 28. februarja 2018 do 27. februarja 2019, so zaznali poročila o primerih iz obdobja trženja in literature o nekrozi prstov in/ali amputaciji in zlomih prstov pri bolnikih z Dupuytrenovo kontraktururo, zdravljenih s kolagenazo clostridium histolyticum.
Both classes of collagenases readily hydrolyze gelatin (denatured collagen) and small collagen peptides, whereas Class II has higher affinity for small collagen fragments. 
Oba razreda kolagenaz z lahkoto hidrolizirata želatino (denaturiran kolagen) in majhne kolagenske peptide, medtem ko imajo kolagenaze razreda II večjo afiniteto za majhne kolagenske fragmente.
What you need to know before you are given Xiapex You must not be given Xiapex: 
Kaj morate vedeti, preden boste dobili zdravilo Xiapex Zdravila Xiapex ne smete dobiti:
Collagenase clostridium histolyticum was not mutagenic in Salmonella typhimurium (AMES test) and was not clastogenic in both an in vivo mouse micronucleus assay and an in vitro chromosomal aberration assay in human lymphocytes. 
Kolagenaza clostridium histolyticum ni bila mutagena v Salmonella typhimurium (Amesov test) in ni bila klastogena v in vivo mikrojedrnih preskušanjih pri miših ter v in vitro preskušanjih kromosomskih aberacij v človeških limfocitih.
After treatment with Xiapex, one of these tubes may break during an erection. 
Po zdravljenju z zdravilom Xiapex se lahko katera od teh cevk med erekcijo zlomi.
Parturition or postnatal development studies in animals were not conducted since human pharmacokinetic studies show that Xiapex levels are not quantifiable in the systemic circulation following injection into a Dupuytren's cord (see section 5.1). 
Študije na živalih o vplivu na porod ali postnatalni razvoj niso bile izvedene, ker človeške farmakokinetične študije kažejo, da nivo zdravila Xiapex v sistemski cirkulaciji po injekciji v Dupuytrenov vozlič ni merljiv (glejte poglavje 5.1).
Following Xiapex injection, severe allergic reaction could occur, and patients should be observed for 30 minutes before leaving the clinic in order to monitor for any signs or symptoms of a serious allergic reaction, e.g. wide spread redness or rash, swelling, tightness in the throat or difficulty breathing. 
Po injiciranju zdravila Xiapex se lahko pojavijo hude alergijske reakcije in bolnike je treba opazovati 30 minut, preden zapustijo kliniko, za spremljanje morebitnih znakov ali simptomov resnih alergijskih reakcij, npr. rdečina ali izpuščaj po celem telesu, oteklina, tiščanje v žrelu ali težave pri dihanju.
Call your doctor right away if you have any of these symptoms of an allergic reaction after an injection of Xiapex: 
Takoj pokličite zdravnika, če imate po injiciranju zdravila Xiapex katerega koli od teh simptomov alergijske reakcije:
Figure 2: Three step injection of Xiapex into the cord. 
Slika 2: trije koraki injiciranja zdravila Xiapex v vozlič
In the retreatment study AUX-CC-862, 150 anti-AUX-I antibody positive samples and 149 anti-AUX-II antibody positive samples were assessed for potential cross-reactivity with human MMPs-1, -2, -3, -8, and -13. 
V študiji ponovnega zdravljenja AUX-CC-862 so ocenili 150 vzorcev, pozitivnih za protitelesa proti AUX-I, in 149 vzorcev, pozitivnih za protitelesa proti AUX-II, glede morebitne navzkrižne reaktivnosti s človeškimi MMP-1, -2, -3, -8 in -13.
• tremor/shaking, increased sensitivity to stimuli 
• tremor/tresavica, povečana občutljivost na dražljaje;
On the basis of the scientific conclusions for collagenase clostridium histolyticum the CHMP is of the opinion that the benefit-risk balance of the medicinal product(s) containing collagenase clostridium histolyticum is unchanged subject to the proposed changes to the product information. 
Na podlagi znanstvenih zaključkov za kolagenazo clostridium histolyticum odbor CHMP meni, da je razmerje med koristjo in tveganjem zdravil(-a), ki vsebuje(-jo) kolagenazo clostridium histolyticum,nespremenjeno ob upoštevanju predlaganih sprememb v informacijah o zdravilu.
After treatment with Xiapex, blood vessels in your penis may also break, causing blood to collect under the skin (which is called a haematoma). 
Po zdravljenju z zdravilom Xiapex lahko počijo tudi krvne žile v penisu, kar povzroči kopičenje krvi pod kožo (to se imenuje hematom).
The recurrence day was the visit where the recurrence was reported or the day of intervention if a joint was treated for a worsening Dupuytren's contracture. 
Dan ponovitve je bil obisk, na katerem je bila ponovitev poročana, ali dan posega, če je bil sklep zdravljen zaradi poslabšanja Dupuytrenove kontrakture.
• You should only gently stretch your penis when you do not have an erection. 
• Penis si lahko nežno raztezate le, ko nimate erekcije.
• agitation, disorientation, irritability, restlessness, difficulty sleeping 
• vznemirjenost, motnje orientacije, razdražljivost, nemir, težave pri spanju;
Open wound 
• odprta rana
Xiapex may have a major influence on the ability to drive and use machines due to the swelling and pain which may impair the use of the treated hand in Dupuytren's disease. 
Zdravilo Xiapex utegne imeti pomemben vpliv na sposobnost vožnje in upravljanja strojev zaradi otekanja in bolečine, ki lahko ovirata uporabo zdravljene roke pri Dupuytrenovi bolezni.
Whilst there is no clinical evidence from the current safety data of a musculoskeletal syndrome developing following the administration of Xiapex, the potential for it to occur cannot be excluded. 
Ker iz trenutnih varnostnih podatkov ni kliničnih dokazov o razvoju mišično-skeletnega sindroma po aplikaciji zdravila XIAPEX, možnosti za njegov razvoj ne moremo izključiti.
Figure 1: Illustration of the injection technique. 
Slika 1: prikaz tehnike injiciranja
Following this disruption of the plaque, penile curvature deformity and patient bother caused by Peyronie's disease are reduced. 
Po prekinitvi plaka se deformacija ukrivljenosti penisa in težave, ki jih bolniku povzroča Peyroniejeva bolezen, zmanjšajo.
If you are treated for Dupuytren's contracture 
Če se zdravite zaradi Dupuytrenove kontrakture
• Wear the splint at bedtime for up to 4 months. 
• naj nosijo opornico ponoči do 4 mesece dolgo,
Long Term Recurrence Rates for Joints Treated Successfully with XIAPEX 
Dolgoročni delež ponovitve za sklepe, uspešno zdravljene z zdravilom XIAPEX
Identification of treatment area a) Prior to each treatment cycle, identify the treatment area as follows: 
Določanje predela zdravljenja a) Pred začetkom cikla zdravljenja določite predel zdravljenja kot sledi:
If you are treated for Peyronie's disease 
Če se zdravite zaradi Peyroniejeve bolezni
For Xiapex no clinical data on exposed pregnancies are available. 
Za zdravilo Xiapex ni na voljo kliničnih podatkov od nosečnic, ki so bile izpostavljene zdravilu.
• worsening of Peyronie's disease 
• poslabšanje Peyroniejeve bolezni
• water retention 
• zastajanje vode
Injection procedure 
Postopek injiciranja
• To promptly contact their doctor if there is evidence of infection (e.g., fever, chills, increasing redness or oedema) or trouble bending the finger after the swelling goes down (symptoms of tendon rupture). 
• naj se takoj obrnejo na svojega zdravnika, če se pojavijo znaki okužbe (npr. vročina, mrzlica, povečanje rdečine ali edem) ali če imajo težave pri pregibanju prsta potem, ko oteklina splahni (simptomi rupture kite);
As with any non-human protein medicinal product, patients may develop antibodies to the therapeutic protein. 
Imunogenost Kot pri drugih zdravilih, ki vsebujejo kakršnekoli beljakovine nehumanega izvora, lahko bolniki razvijejo protitelesa proti terapevtski beljakovini.
Following extension of your finger, your doctor will fit you with a splint to wear at bedtime for up to 4 months. 
Po iztegovanju prstov vam bo zdravnik namestil opornico, da jo boste nosili ponoči do 4 mesece dolgo.
The solution must be clear, colourless with no lumps or flakes or particles. 
Raztopina mora biti bistra, brezbarvna, brez grudic ali kosmičev ali delcev.
• Not to flex or extend the fingers of the injected hand to reduce extravasation of Xiapex out of the cord until the finger extension procedure is completed. 
• naj ne krčijo ali iztegujejo prstov zdravljene roke, da ne bi zdravilo Xiapex uhajalo ven iz vozliča, dokler postopek iztegovanja prstov ne bo zaključen;
The mean (SD) FSFI score was 20.56 (10.08) at baseline and 26.72 (7.73) at week 36, a change from baseline of 7.54. 
Povprečni (SD) seštevek FSFI je bil 20,56 (10,08) ob izhodšiču in 26,72 (7,73) v 36. tednu, tj. sprememba od izhodišča 7,54.
Contents of the pack and other information What Xiapex contains 
Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Xiapex
• For Peyronie's disease if the treatment of your plaque involves the tube (called the urethra) that your urine passes through. 
• za Peyronijevo bolezen, če je v zdravljenje plaka vpletena cevka (imenovana sečnica), skozi katero prehaja urin.
b A recurrent joint was a joint evaluated by the investigator as having a worsening Dupuytren's contracture due to a palpable cord. 
b Sklep, pri katerem je prišlo do ponovitve, je bil sklep, ki ga je raziskovalec ocenil s poslabšanjem Dupuytrenove kontrakture zaradi otipljivega vozliča.
In addition, based on the review of post marketing case reports of penile fracture in patients with Peyronie's disease, the PRAC considers that the product information for Xiapex should be updated to include a new wording for section 4.4 of the SmPC and section 2 of the PIL to increase the minimum time span between injection and resumption of sexual activity to at least 4 weeks and to be cautious when resuming sexual activity. 
Poleg tega je treba na podlagi pregleda poročil o primerih iz obdobja trženja o zlomih penisa pri bolnikih s Peyroniejevo boleznijo odbor PRAC meni, da je treba informacije o zdravilu Xiapex posodobiti tako, da se vključi novo besedilo v poglavje 4.4 povzetka glavnih značilnosti zdravila in poglavje 2 navodila za uporabo, da se poveča najkrajše časovno obdobje med injiciranjem in ponovno spolno aktivnostjo na najmanj 4 tedne, in da je potrebna pri ponovni spolni aktivnosti previdnost.
The adverse reaction profile was similar after each injection, regardless of the number of injections administered. 
Profil neželenih učinkov je bil podoben po vsakem injiciranju, ne glede na število danih injekcij.
The recommended dose of your prescribed medicine is 0.58 mg. 
Priporočen odmerek predpisanega zdravila je 0,58 mg.
Severe allergic reactions can happen in patients who receive Xiapex, because it contains proteins foreign to the human body. 
Bolniki, ki prejmejo zdravilo Xiapex, lahko doživijo hude alergijske reakcije, saj zdravilo vsebuje človeškemu telesu tuje beljakovine.
*A formulation of two collagenase enzymes co-expressed and harvested from anaerobic fermentation of a phenotypically selected strain of Clostridium histolyticum bacterium. 
*Formulacija dveh encimov kolagenaz, ki se izražata skupaj in ju pridelajo z anaerobno fermentacijo fenotipsko izbranega seva bakterije Clostridium histolyticum.
If this syndrome were to develop, it would occur progressively and is characterized by one or more of the following signs and symptoms: arthralgia, myalgia, joint stiffness, stiffness of the shoulders, hand oedema, palmar fibrosis and thickening or nodules forming in the tendons. 
Če bi se ta sindrom razvil, bi se pojavil progresivno in zanj bi bili značilni eden ali več naslednjih znakov in simptomov: artralgija, mialgija, otrdelost sklepov, otrdelost v ramenih, edem rok, palmarna fibroza in zadebelitev ali nastajanje vozličev v kitah.
The double-blind study population comprised 409 patients of whom 272 received Xiapex 0.58 mg and 137 received placebo. 
Populacijo dvojno slepe študije je sestavljalo 409 bolnikov, od katerih jih je 272 prejemalo zdravilo Xiapex 0,58 mg in 137 jih je prejemalo placebo.
At study entry, patients in the clinical studies had: (1) a finger flexion contracture with a palpable cord of at least one finger (other than the thumb) of 20° to 100° in a MP joint or 20° to 80° in PIP joint and (2) a positive “table top test” defined as the inability to simultaneously place the affected finger(s) and palm flat against a table top. 
Ob vključitvi v študijo so imeli bolniki v kliničnih študijah: (1) fleksijsko kontrakturo prsta z otipljivim vozličem na vsaj enem prstu (razen na palcu) 20° do 100° v MP sklepu ali 20° do 80° v PIP sklepu in (2) pozitiven “test mize”, ki je definiran kot nezmožnost hkratne postavitve prizadetega prsta (prstov) in dlani ravno na površino mize.
For Dupuytren's disease, Xiapex breaks down the collagen forming the cord and thereby releasing the contracture completely or partly and enabling your finger(s) to be straighter. 
Pri Dupuytrenovi bolezni zdravilo Xiapex razgradi kolagen, ki tvori vozlič, in s tem kontrakturo povsem ali delno sprosti ter omogoči prstu(om), da so bolj ravni.
In the controlled and uncontrolled clinical studies of Xiapex in Peyronie's disease corporal rupture and other serious penile injury were reported uncommonly (see section 4.4) 
V nadzorovanih in nenadzorovanih kliničnih študijah z zdravilom Xiapex za Peyroniejevo bolezen so občasno poročali o rupturi korpusa in drugih resnih poškodbah penisa (glejte poglavje 4.4)
• breathing trouble 
• težave z dihanjem
Signs or symptoms that may reflect serious injury to the treated finger/hand after injection or manipulation should be promptly evaluated because surgical intervention may be required. 
Znake ali simptome, ki lahko kažejo na resno poškodbo zdravljenega prsta/roke po injiciranju ali obravnavi, je treba hitro oceniti, ker je morda potreben kirurški poseg.
Reconstitute with appropriate volume before use. 
Samo za intralezijsko uporabo Pred uporabo rekonstituirajte z ustreznim volumnom.
The flip-off plastic caps should be removed from both vials. 
Z obeh vial je treba odstraniti plastično dvižno zaporko.
In the pivotal clinical studies about 30% of the patients received penile block before injection. 
V ključnih kliničnih študijah je blokado penisa pred injiciranjem prejelo približno 30 % bolnikov.
What Xiapex is and what it is used for 
Kaj je zdravilo Xiapex in za kaj ga uporabljamo
Each vial of Xiapex and sterile solvent for reconstitution should only be used for a single injection. 
Vsako vialo zdravila Xiapex in sterilni vehikel za rekonstitucijo se lahko uporabi le za eno injekcijo.
N (%) of Recurrent Joints in Each Intervalb 
N (%) sklepov s ponovitvij o za vsak interval b
Different Fingers, Both PIPs (n=72) 
Različna prsta, oba PIP (n = 72)
Anaphylactic reaction was reported in a patient previously treated with Xiapex (1 case). 
O anafilaktični reakciji so poročali pri bolniku, predhodno zdravljenemu z zdravilom Xiapex (1 primer).
Your doctor will take care to avoid injecting into tendons, nerves or blood vessels. 
Zdravnik bo pri tem pazil, da ne bo injiciral v kite, živce ali krvne žile.
If your finger is still not able to straighten during a follow-up visit with your doctor, you may need additional treatments with Xiapex which may be administered approximately 4 weeks after the first treatment. 
Če svojega prsta med kontrolnim pregledom ne boste mogli iztegniti, boste morda potrebovali dodatna zdravljenja z zdravilom Xiapex, ki se ga lahko daje v razmaku 4 tedne po prvem zdravljenju.
It is not known whether collagenase clostridium histolyticum is excreted in human milk. 
Ni znano, ali se kolagenaza clostridium histolyticum izloča v materino mleko.
Adverse reactions reported from the clinical programme are those that occurred in the Phase 3 double-blind placebo-controlled studies. 
Neželeni učinki, o katerih so poročali iz kliničnega programa, so tisti, ki so se zgodili v dvojno slepih, s placebom nadzorovanih študijah 3. faze.
• Gently pull your penis away from your body to its full length and hold the stretch for 
• Penis nežno povlecite stran od telesa do celotne dolžine in ga držite iztegnjenega 30 sekund.
Clinically meaningful improvement in hand function as determined by the URAM (Unite´ Rhumatologique des Affections de la Main) score was observed at Day 31 (-11.3) and Day 61 (-12.3). 
Klinično pomembno izboljšanje funkcije roke, določeno po lestvici URAM (Unite´ Rhumatologique des Affections de la Main), so opazili na 31. dan
Store in a refrigerator at 2ºC-8ºC. 
Shranjujte v hladilniku pri 2 ºC-8 ºC.
No patients had quantifiable plasma levels 15 minutes after modelling of plaque on Day 3 (i.e., 24 hours after Injection 2 on Day 2). 
Noben od bolnikov 15 minut po modeliranju plaka 3. dan (tj. 24 ur po 2. injekciji 2. dan) ni imel merljivih ravni v plazmi.
Tendon rupture or other serious injury to the injected finger/hand in the treatment of Dupuytren's contracture 
Ruptura kite ali druge resne poškodbe na zdravljenem prstu/zdravljeni roki pri zdravljenju Dupuytrenove kontrakture