natgillin/translations-raw huggingface dataset:
For storage conditions of the reconstituted medicine, see 'Handling instructions' at the end of this package leaflet. 
Za pogoje shranjevanja rekonstituiranega zdravila glejte poglavje »Navodila za ravnanje« na koncu tega navodila za uporabo.
Use with other cyanide antidotes 
Uporaba z drugimi antidoti za cianid
The effectiveness of hydroxocobalamin was examined in a controlled study in cyanide-poisoned adult dogs. 
Učinkovitost hidroksokobalamina so ugotavljali v nadzorovani študiji na odraslih psih, zastrupljenih s cianidom.
Because the reconstituted solution is a dark red solution, some insoluble particles may not be seen. 
Rekonstituirana raztopina je temno rdeča, zato morda nekateri netopni delci niso vidni.
The pharmacokinetics of total cobalamins-(III) in this population may be affected by the body's cyanide load, since cyanocobalamin was reported to exhibit a 2-3 times lower half-life than total cobalamins-(III) in healthy volunteers. 
Na farmakokinetiko skupnih kobalaminov-(III) pri teh bolnikih lahko vpliva obremenitev telesa s cianidom, saj so poročali, da je razpolovni čas cianokobalamina 2- do 3-krat krajši kot razpolovni čas skupnih kobalaminov-(III) pri zdravih prostovoljcih.
Where neurological assessment over time was possible, (96 patients of the 171 patients who presented with neurological symptoms prior to hydroxocobalamin administration), 51 (53%) patients receiving hydroxocobalamin showed improvement or a complete restoration. 
Od bolnikov, pri katerih je bila ocena nevrološkega stanja po zdravljenju mogoča (96 od 171 bolnikov, ki so pred uporabo hidroksokobalamina imeli nevrološke simptome), je pri 51 bolnikih (53%), ki so prejeli hidroksokobalamin, prišlo do izboljšanja ali popolnega okrevanja.
In the setting of multiple casualties such as terrorism or chemical disaster, panic symptoms including tachypnoea and vomiting may mimic early cyanide poisoning signs. 
Pri nesrečah z več žrtvami, kot so teroristični napadi ali kemijske nesreče, so lahko simptomi panike, vključno s tahipnejo in bruhanjem, podobni zgodnjim znakom zastrupitve s cianidom.
Pharmacotherapeutic group: Antidotes, ATC code: V03AB33 
FARMAKOLOŠKE LASTNOSTI 5.1 Farmakodinamične lastnosti Farmakoterapevtska skupina: Antidoti, oznaka ATC: V03AB33
If there is clinical suspicion of cyanide poisoning, it is strongly recommended that Cyanokit be administered without delay. 
Če obstaja klinični sum na zastrupitev s cianidom, je močno priporočeno uporabiti zdravilo Cyanokit brez odlašanja.
The mean total amount of cobalamins-(III) excreted in urine during the collection period of 72 hours was approximately 60% of a 5 g dose and approximately 50% of a 10 g dose of Cyanokit. 
Povprečna skupna količina kobalaminov-(III), izločenih z urinom v 72-urnem obdobju zbiranja, je bila pri 5-gramskem odmerku zdravila Cyanokit približno 60%, pri 10-gramskem pa približno 50%.
As physical and chemical incompatibilities were observed with a number of selected medicinal products that are frequently used in resuscitation efforts, these and other medicinal products must not be administered simultaneously in the same intravenous line as hydroxocobalamin. 
Ker so pri številnih izbranih zdravilih, ki se pogosto uporabljajo pri oživljanju, opazili fizikalne in kemijske inkompatibilnosti, se ta in druga zdravila ne smejo dajati sočasno po isti intravenski liniji kot hidroksokobalamin.
• Acute renal failure with acute tubular necrosis, renal impairment, urine calcium oxalate crystals present (see section 4.4). 
• Akutna odpoved ledvic z akutno tubularno nekrozo, okvaro ledvic in prisotnostjo kristalov kalcijevega oksalata v urinu (glejte poglavje 4.4).
- burn assessement. 
oceno opeklin.
Doses as high as 15 g have been administered without reported specific dose related adverse reactions. 
Odmerke do 15 g so aplicirali brez specifičnih neželenih učinkov, odvisnih od odmerka.
Cyanokit may interfere with the assessment as it causes red coloration of the skin. 
Zdravilo Cyanokit lahko vpliva na oceno, saj povzroča rdeče obarvanje kože.
Your doctor or health care professional will give you Cyanokit by infusion into a vein. 
Zdravnik ali zdravstveno osebje vam bodo zdravilo Cyanokit infundirali v veno.
What you need to know before Cyanokit is used 
Kaj morate vedeti pred uporabo zdravila Cyanokit
Interference with laboratory tests 
Motenje laboratorijskih preiskav
Out of the 20 paediatric patients without initial cardiac arrest, 18 (90%) survived, of whom 4 with sequelae. 
Od 20 pediatričnih bolnikov, ki niso imeli srčnega zastoja, jih je preživelo 18 (90 %), med njimi 4 s posledicami.
Aspartate aminotransferase (AST) 
Sečna kislina Aspartataminotransferaza (AST)
This kit does not contain diluent. 
Komplet ne vsebuje topila.
The action of hydroxocobalamin in the treatment of cyanide poisoning is based on its ability to tightly bind cyanide ions. 
Delovanje hidroksokobalamina pri zdravljenju zastrupitve s cianidom temelji na njegovi zmožnosti močne vezave cianidnih ionov.
When normalized for body weight, male and female subjects revealed no major differences in plasma and urinary pharmacokinetic parameters of free and total cobalamins-(III) following the administration of 5 g or 10 g Cyanokit. 
Pri normalizaciji na telesno maso pri moških in ženskah ni bilo pomembnih razlik pri plazemskih in urinskih farmakokinetičnih parametrih prostih in skupnih kobalaminov-(III) po uporabi 5 g ali 10 g zdravila Cyanokit.
For the purpose of ambulatory use, Cyanokit may be exposed during short periods to the temperature variations of 
Pri ambulantni uporabi se lahko zdravilo Cyanokit za kratek čas izpostavi naslednjim temperaturnim območjem:
The safety of administering other cyanide antidotes simultaneously with Cyanokit has not been established (see section 6.2). 
Varnost sočasne uporabe drugih antidotov proti cianidu in zdravila Cyanokit ni ugotovljena (glejte poglavje 6.2).
Cyanokit may cause red discolouration of the plasma, which may cause artificial elevation or reduction in the levels of certain laboratory parameters (see section 4.4). 
Zdravilo Cyanokit lahko povzroči rdeče obarvanje plazme, ki lahko umetno zviša ali zniža ravni nekaterih laboratorijskih parametrov (glejte poglavje 4.4).
In the presence of the above signs, treatment with Cyanokit must not be delayed to obtain a plasma lactate concentration. 
Če so prisotni zgoraj navedeni znaki, se zdravljenja z zdravilom Cyanokit ne sme odlašati zaradi določanja koncentracije laktata v plazmi.
Creatine kinase (CK) Creatine kinase isoenzym MB (CKMB) 
Kreatin-kinaza (CK) Kreatin-kinaza izoencim MB (CKMB)
The mean age of the paediatric patients was about six years and the mean dose of hydroxocobalamin was about 120 mg/kg body weight. 
Povprečna starost pediatričnih bolnikov je bila približno 6 let, povprečen odmerek hidroksokobalamina pa približno 120 mg/kg telesne mase.
You will have the first infusion of Cyanokit over 15 minutes. 
Prvo infundiranje zdravila Cyanokit bo trajalo 15 minut.
Consideration must be given to decontamination measures based on the route of exposure. 
Glede na pot izpostavitve je treba poskrbeti tudi za dekontaminacijske ukrepe.
Subsequent dose 
Naslednji odmerek
Each pack contains two vials (each vial packed in one cardboard box), two sterile transfer devices, one sterile intravenous infusion set and one sterile short catheter for administration to children. 
V enem pakiranju sta po dve viali (vsaka viala je pakirana v kartonsko škatlo), dve sterilni napravi za prenos, en sterilen komplet za intravensko infundiranje in en sterilen kratek kateter za uporabo pri otrocih.
Not all smoke inhalation victims necessarily will have cyanide poisoning, but may present with burns, trauma, and exposure to additional toxic substances aggravating the clinical picture. 
Ni nujno, da so vse žrtve vdihavanja dima zastrupljene s cianidom, vendar opekline, poškodbe in izpostavljenost drugim strupenim snovem lahko poslabšajo klinično sliko.
Furthermore, in 34 patients with known cyanide concentrations above the lethal threshold (≥ 100 µmol/L), 21 (62%) survived following treatment with hydroxocobalamin. 
Od 34 bolnikov, pri katerih so bile koncentracije cianida nad pragom smrtnega odmerka (≥ 100 µmol/l), jih je po zdravljenju s hidroksokobalaminom preživelo 21 (62 %).
For adults, the initial dose is 5 g. For children, it is 70 mg/kg body weight, up to a maximum dose of 5 g. If you need a second infusion, you will have it over 15 minutes to 2 hours. 
Začetni odmerek za odrasle je 5 g. Za otroke je 70 mg/kg telesne mase, do največjega odmerka 5 g. Če potrebujete drugo infundiranje, bo trajalo 15 minut do 2 uri.
Therefore, as a precaution, after Cyanokit administration, regular monitoring of renal function (including blood urea nitrogen and serum creatinine) should be performed until 7 days after drug onset. 
Zato je zaradi previdnosti potrebno po dajanju zdravila Cyanokit redno spremljanje delovanja ledvic (vključno z dušikomsečnine v krvi in kreatininom v serumu) do 7 dni po uvedbi zdravila.
• breathing difficulties 
• težave pri dihanju
It must not be shaken as shaking the vial may cause foam and therefore may make checking reconstitution less easy. 
Viale ne smete pretresati, ker se zaradi pretresanja lahko ustvari pena, zaradi česar se težje vidi, ali je rekonstitucija uspela.
Allergic reactions including angioneurotic oedema, skin eruption, urticaria and pruritus. 
Alergijske reakcije, vključno z angionevrotičnim edemom, kožnim izpuščajem, urtikarijo in pruritusom.
Sources of cyanide poisoning include hydrogen cyanide and its salts, cyanogens, including cyanogenic plants, aliphatic nitriles, or prolonged exposure to sodium nitroprusside. 
Med viri zastrupitve s cianidom so vodikov cianid in njegove soli, cianogeni, vključno s cianogenimi rastlinami, alifatskimi nitrili ali dolgotrajno izpostavljenostjo natrijevemu nitroprusidu.
Initial dose of Cyanokit is administered as an intravenous infusion over 15 minutes. 
Začetni odmerek zdravila Cyanokit se daje v obliki 15-minutne intravenske infuzije.
In anaesthetised rabbits, hydroxocobalamin exerted haemodynamic effects (increased mean arterial blood pressure and total peripheral resistance, decreased cardiac output) related to its nitric oxidescavenging property. 
Pri anesteziranih kuncih je imel hidroksokobalamin hemodinamične učinke (zvišan povprečni arterijski krvni tlak in skupni periferni upor, zmanjšan srčni iztis), povezane z njegovo lastnostjo odstranjevanja dušikovega oksida.
Interference with burn assessment 
Motenje ocenjevanja stopnje opeklin
Simultaneous administration of hydroxocobalamin and blood products (whole blood, packed red cells, platelet concentrate and fresh frozen plasma) through the same intravenous line is not recommended. 
Sočasna uporaba hidroksokobalamina in krvnih izdelkov (polne krvi, koncentrata eritrocitov, koncentrata trombocitov in sveže zamrznjene plazme) po isti intravenski liniji ni priporočena.
Because of its deep red colour, hydroxocobalamin has the potential to interfere with determination of laboratory parameters (e.g. clinical chemistry, haematology, coagulation, and urine parameters). 
Hidroksokobalamin je temno rdeč, zato lahko moti določanje laboratorijskih parametrov (npr. parametrov klinične kemije, hematologije, koagulacije in urina).
Among 144 patients not in initial cardiac arrest whose outcomes were known, 118 (82%) survived. 
Od 144 bolnikov, za katere je izid znan in ki niso imeli srčnega zastoja, jih je preživelo 118 (82%).
The Cyanokit vial is to be rocked or inverted for at least 1 minute to mix the solution. 
Vialo z zdravilom Cyanokit je treba zibati ali obračati vsaj 1 minuto, da se raztopina premeša.
Histopathology revealed brain lesions that were consistent with cyanide-induced hypoxia. 
Histopatološke preiskave so pokazale možganske lezije, značilne za hipoksijo, ki jo povzroča cianid.
Sodium chloride 9 mg/mL (N=17) 
Natrijev klorid 9 mg/ml (N=17)
The 75 mg/kg and 150 mg/kg doses are approximately equivalent to 5 g and 10 g of hydroxocobalamin, respectively, in humans, not only on a body weight basis but also on Cmax basis of hydroxocobalamin [total cobalamins-(III), see section 5.2]. 
Odmerek 75 mg/kg približno ustreza odmerku 5 g hidroksokobalamina pri človeku, 150 mg/kg pa 10 g hidroksokobalamina, ne le na podlagi telesne mase, ampak tudi na podlagi vrednosti Cmax [skupni kobalamini-(III), glejte poglavje 5.2].
If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 6 hours at 2°C to 8°C. 
Če se zdravilo ne uporabi takoj, je za čas in pogoje shranjevanja raztopine pred uporabo odgovoren uporabnik, ti pa normalno ne smejo biti daljši kot 6 ur pri 2 °C do 8 °C.
Because of its deep red color, hydroxocobalamin may cause haemodialysis machines to shut down due to an erroneous detection of a ‘blood leak'. 
Zaradi svoje temno rdeče barve lahko hidroksokobalamin povzroči, da se aparature za hemodializo izklopijo zaradi napačne zaznave „iztekanja krvi“.
What Cyanokit is and what it is used for What you need to know before Cyanokit is used How Cyanokit is used 
Kaj je zdravilo Cyanokit in za kaj ga uporabljamo Kaj morate vedeti pred uporabo zdravila Cyanokit Kako uporabljati zdravilo Cyanokit Možni neželeni učinki
A total of 347 subjects were exposed to hydroxocobalamin in clinical studies. 
V kliničnih študijah so hidroksokobalaminu izpostavili skupaj 347 oseb.
Dose-proportional pharmacokinetics were observed following single dose intravenous administration of 2.5 to 10 g of Cyanokit in healthy volunteers. 
Farmakokinetika po intravenski uporabi enkratnega odmerka 2,5 do 10 g zdravila Cyanokit pri zdravih prostovoljcih je bila odvisna od odmerka.
Depending upon the severity of the poisoning and the clinical response, a second dose may be administered 
Glede na stopnjo zastrupitve in klinični odziv lahko dajete naslednji odmerek.
The Cyanokit vial is to be rocked or inverted for at least 30 seconds to mix the solution. 
Vialo z zdravilom Cyanokit je treba zibati ali obračati vsaj 30 sekund, da se raztopina premeša.
• kidney injuries such as acute kidney impairment and urine crystals. 
• poškodbe ledvic, kot je akutna okvara ledvic in kristali v urinu
• Animal pharmacology 
• Farmakologija pri živalih
Urine colouration may last up to 35 days after administration of Cyanokit. 
Obarvanje urina lahko traja do 35 dni po uporabi zdravila Cyanokit.
Of these 347 subjects, 245 patients had suspected exposure to cyanide at the time of hydroxocobalamin administration. 
Med temi 347 osebami je pri 245 bolnikih v času uporabe hidroksokobalamina obstajal sum na izpostavljenost cianidu.
Combination with another cyanide antidote: Chemical incompatibility was observed with sodium thiosulfate and sodium nitrite. 
Kombiniranje z drugimi antidoti proti cianidu: Kemijsko inkompatibilnost so opazili pri natrijevem tiosulfatu in natrijevem nitritu.
Treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of seizures. 
Pri zdravljenju zastrupitve s cianidom je treba takoj poskrbeti za prehodnost dihalnih poti, ustrezno oksigenacijo in hidracijo, kardiovaskularno podporo in obravnavanje epileptičnih napadov.
Common signs and symptoms of cyanide poisoning include: nausea, vomiting, headache, altered mental status (e.g. confusion, disorientation), chest tightness, dyspnoea, tachypnoea or hyperpnoea (early), bradypnoea or apnoea (late), hypertension (early) or hypotension (late), cardiovascular collapse, seizures or coma, mydriasis, and plasma lactate concentration > 8 mmol/L. 
Med pogostimi znaki in simptomi zastrupitve s cianidom so: navzea, bruhanje, glavobol, sprememba duševnega stanja (npr. zmedenost, dezorientiranost), tiščanje v prsnem košu, dispneja, tahipneja ali hiperpneja (zgodaj), bradipneja ali apneja (pozno), hipertenzija (zgodaj) ali hipotenzija (pozno), kardiovaskularni kolaps, epileptični napadi ali koma, midriaza in koncentracija laktata v plazmi > 8 mmol/l.
They will have to take it into account before treating you with Cyanokit. 
To bodo upoštevali pred zdravljenjem z zdravilom Cyanokit.
Hydroxocobalamin will lower blood cyanide concentrations. 
Hidroksokobalamin zniža koncentracijo cianida v krvi.
Your doctor will recommend you to stop breast-feeding after treatment with Cyanokit. 
Zdravnik vam bo priporočil, da po zdravljenju z zdravilom Cyanokit prenehate dojiti.
MEDICAL OR HEALTH CARE PROFESSIONALS EDUCATIONAL STICKER 
INFORMATIVNA NALEPKA ZA ZDRAVNIKE ALI ZDRAVSTVENO OSEBJE
The intravenous infusion set provided in the kit must then be used as it includes an appropriate filter and is to be primed with the reconstituted solution. 
Uporabiti je treba priložen komplet za intravensko infundiranje, ker vsebuje ustrezen filter, komplet za intravensko infundiranje pa je treba napolniti z rekonstituirano raztopino.
One transfer device. 
Ena naprava za prenos.
• transport in the desert (4 days submitted to temperatures ranging from 5 to 60°C) and 
• prevoz v puščavi (4 dni izpostavljenosti temperaturam od 5 °C do 60 °C) in
If blood products (whole blood, packed red cells, platelet concentrate and fresh frozen plasma) and hydroxocobalamin are administered simultaneously, use of separate intravenous lines (preferably on contralateral extremities) is recommended. 
Če sočasno uporabljate krvne izdelke (polno kri, koncentrat eritrocitov, koncentrat trombocitov in sveže zamrznjeno plazmo) in hidroksokobalamin, je priporočena uporaba ločenih intravenskih linij (po možnosti na nasprotnih okončinah).
Urine colouration may last up to 35 days after administration of Cyanokit (see section 4.4). 
Obarvanje urina lahko traja do 35 dni po uporabi zdravila Cyanokit (glejte poglavje 4.4).
Cyanokit may interfere with burn assessment (red coloration of the skin) and laboratory tests and may lead to shut down of haemodialysis machines (see SmPC).” 
Zdravilo Cyanokit lahko moti ocenjevanje stopnje opeklin (povzroči rdeče obarvanje kože) in rezultate laboratorijskih preiskav in lahko povzroči, da se aparature za hemodializo izklopijo (glejte povzetek glavnih značilnosti zdravila).”
Cyanide poisoning may be caused by exposure to smoke from household and industrial fires, breathing or swallowing cyanide, or contact with cyanide on skin. 
Zastrupitev s cianidom lahko povzroči izpostavljenost dimu pri požarih v gospodinjstvu in industriji, vdihovanje ali zaužitje cianida ali stik s cianidom prek kože.
Each pack contains one vial packed in one cardboard box, one sterile transfer device, one sterile intravenous infusion set and one sterile short catheter for administration to children. 
V enem pakiranju je ena viala, pakirana v eno kartonsko škatlo, ena sterilna naprava za prenos, en sterilen komplet za intravensko infundiranje in en sterilen kratek kateter za uporabo pri otrocih.
Each hydroxocobalamin molecule can bind one cyanide ion by substituting the hydroxo ligand linked to the trivalent cobalt ion to form cyanocobalamin. 
Vsaka molekula hidroksokobalamina lahko veže en cianidni ion ob substituciji hidrokso-liganda, ki je vezan na trivalentni kobaltov ion, pri čemer nastane cianokobalamin.
However, skin lesions, oedema, and pain are highly suggestive of burns. 
Vendar so za opekline zelo značilne kožne lezije, edem in bolečina.
However, hydroxocobalamin because of its deep red colour may interfere with the performance of haemodialysis machines (see section 4.4). 
Vendar pa lahko hidroksokobalamin zaradi svoje temno rdeče barve moti delovanje aparatur za hemodializo (glejte poglavje 4.4).
In the absence of data in breast-fed infants, breast-feeding discontinuation is recommended after receiving Cyanokit. 
Ker ni na voljo podatkov pri dojenih otrocih, se po uporabi zdravila Cyanokit priporoča prekinitev dojenja.
Physical incompatibility (particle formation) was observed with the mixture of hydroxocobalamin reconstituted solution and the following medicinal products: diazepam, dobutamine, dopamine, fentanyl, nitroglycerin, pentobarbital, phenytoin sodium, propofol and thiopental. 
Fizikalno inkompatibilnost (nastanek delcev) so opazili pri mešanju rekonstituirane raztopine hidroksokobalamina in naslednjih zdravil: diazepam, dobutamin, dopamin, fentanil, nitroglicerin, pentobarbital, natrijev fenitoin, propofol in tiopental.
However, if a cyanide blood level determination is planned, it is recommended to draw the blood sample before initiation of treatment with Cyanokit. 
Če pa se načrtuje določanje ravni cianida v krvi, je priporočeno odvzeti vzorec krvi pred začetkom zdravljenja z zdravilom Cyanokit.
In cyanide-poisoned patients, hydroxocobalamin is expected to bind cyanide to form cyanocobalamin, which is excreted in the urine. 
Pri bolnikih, zastrupljenih s cianidom, je pričakovati, da bo hidroksokobalamin vezal cianid, pri čemer bo nastal cianokobalamin, ki se izloča z urinom.
Smoke inhalation 
Vdihavanje dima
• The active substance is hydroxocobalamin. 
• Zdravilna učinkovina je hidroksokobalamin.
monitoring of renal function: Cyanokit may lead to kidney failure and urine crystals. 
spremljanje delovanja ledvic: zdravilo Cyanokit lahko povzroči odpoved ledvic in kristale v urinu.
• most patients will experience a reversible red colouration of the skin and membranes lining body cavities (mucous membranes) that may last up to 15 days after administration of Cyanokit. 
• pri večini bolnikov se bo pojavilo reverzibilno rdeče obarvanje kože in sluznic telesnih votlin, ki lahko traja do 15 dni po uporabi zdravila Cyanokit
The liver and kidney were found to be the major target organs. 
Ugotovili so, da sta glavna ciljna organa jetra in ledvice.
Breathing and chest problems 
Težave pri dihanju in težave v prsnem košu
If a cyanide blood level determination is planned, it is recommended to draw the blood sample before initiation of treatment with Cyanokit. 
Če se načrtuje določanje ravni cianida v krvi, je priporočeno odvzeti vzorec krvi pred začetkom zdravljenja z zdravilom Cyanokit.
• The other ingredient is hydrochloric acid (for pH adjustment). 
• Druga sestavina zdravila je klorovodikova kislina (za uravnavanje pH).
Detailed information for your doctor or other health care professional regarding simultaneous administration of Cyanokit with other medicines can be found at the end of this package leaflet (see 'Handling instructions'). 
Podrobne informacije za zdravnika ali drugo zdravstveno osebje o sočasni uporabi zdravila Cyanokit in drugih zdravil so na koncu tega navodila (glejte »Navodila za ravnanje«).
• irregular heart beat 
• neredno bitje srca
The presence and extent of cyanide poisoning are often initially unknown. 
Zastrupitev s cianidom je pogosto sprva neopažena, njena stopnja pa neznana.
• freezing/defrosting cycles (15 days submitted to temperatures ranging from -20 to 40°C). 
• cikli zamrzovanja/odmrzovanja (15 dni izpostavljenosti temperaturam od -20 °C do 40 °C)
Preparation of Cyanokit 
Priprava zdravila Cyanokit
Detailed instructions for your doctor or other health care professional on how to prepare the Cyanokit infusion and how to determine the dose can be found at the end of this package leaflet (see 'Handling instructions'). 
Podrobne informacije za zdravnika ali drugo zdravstveno osebje o pripravi infuzije zdravila Cyanokit in določanju odmerka so na koncu tega navodila (glejte »Navodila za ravnanje«).
Other medicines and Cyanokit 
Druga zdravila in zdravilo Cyanokit
Hydroxocobalamin reduced whole blood cyanide concentrations from about 120 nmol/mL to 30-40 nmol/mL by the end of the infusion compared with 70 nmol/mL in dogs receiving sodium chloride 9 mg/mL alone. 
Hidroksokobalamin je ob koncu infundiranja zmanjšal celotno koncentracijo cianida v krvi s približno 120 nmol/ml na 30-40 nmol/ml, pri psih, ki so prejemali samo 9 mg/ml natrijevega klorida, pa je koncentracijo zmanjšal na 70 nmol/ml.
Following intravenous administration of Cyanokit, significant binding to plasma proteins and low molecular weight physiological compounds occurs, to form various cobalamin-(III) complexes by replacing the hydroxo ligand. 
Po intravenski uporabi zdravila Cyanokit pride do pomembne vezave na beljakovine v plazmi in pojava fizioloških spojin z majhno molsko maso, ki s substitucijo hidrokso liganda tvorijo različne komplekse kobalamina-(III).