natgillin/translations-raw huggingface dataset:
- Just after an injection, your muscles may feel tense or very weak - as though you are having a relapse. 
- Takoj po injiciranju boste morda občutili napetost ali izjemno slabotnost v mišicah - kot da se je bolezen ponovila.
This is what causes the symptoms of MS. Avonex seems to work by stopping your body's defence system from attacking the myelin. 
Kaže, da zdravilo Avonex deluje tako, da onemogoči obrambnemu sistemu vašega telesa, da bi napadel mielin.
Excipient(s) with known effect For the full list of excipients, see section 6.1. 
Pomožna(e) snov(i) z znanim učinkom: Za celoten seznam pomožnih snovi glejte poglavje 6.1.
With one hand, stretch the skin around the injection site. 
Z eno roko napnite kožo okoli mesta injiciranja.
Make sure the cap is intact and has not been opened. 
Preverite, da je pokrovček nepoškodovan in da ni bil odprt.
Patient-time is the sum of individual units of time that the patient in the study has been exposed to AVONEX before experiencing the adverse reaction. 
Produkt števila bolnikov in časa je seštevek posameznih enot časa, ko je bil bolnik v študiji izpostavljen zdravilu AVONEX, preden je imel neželeni pojav.
Other medicines and AVONEX 
Druga zdravila in zdravilo AVONEX
- Patients with a history of hypersensitivity to natural or recombinant interferon beta or to any excipients listed in section 6.1. 
- Pri bolnikih, ki so že imeli preobčutljivostno reakcijo na naravni ali rekombinantni interferon-β ali katero koli pomožno snov, navedeno v poglavju 6.1.
The syringe will not empty. 
Injekcijska brizga se ne bo izpraznila.
Uncommon (≥1/1, 000 to <1/100 patient-years); Rare (≥1/10, 000 to <1/1,000 patient-years); Very rare (<1/10,000 patient-years); 
Občasni (≥1/1.000 do <1/100 bolnikov-let); Redki (≥1/10.000 do <1/1.000 bolnikov-let); Zelo redki (<1/10.000 bolnikov-let);
Check the blister tray contains one pre-filled syringe and one injection needle (see picture “Contents of the plastic tray”). 
Preverite, ali ovoj vsebuje eno napolnjeno injekcijsko brizgo in eno injekcijsko iglo (glejte sliko „Vsebina plastičnega ovoja“).
3 Give the injection 
3 Dajte injekcijo.
Keep the skin stretched tightly or squeeze the skin around the injection site, and pull out the needle. 
Izvlecite iglo Držite kožo tesno napeto ali pa kožo okoli mesta vboda stiskajte in izvlecite iglo.
This is a specially designed holder to help you with injecting Avonex. 
To je posebej zasnovano držalo, ki vam bo v pomoč pri injiciranju zdravila Avonex.
Your doctor may want to check your blood pressure, blood (platelet count) and the function of your kidneys. 
Zdravnik bo morda želel spremljati vaš krvni tlak, krvno sliko (število krvnih ploščic) in delovanje vaših ledvic.
- Feeling faint: Your first injection of Avonex may be given by your doctor. 
- Občutek šibkosti: Prvo injekcijo zdravila Avonex vam mora injicirati zdravnik.
• Use a different injection site each week. 
• Vsak teden uporabite drugo mesto injiciranja.
Tip: Do not press the blue activation button at the same time. 
Nasvet: modrega sprožilnega gumba ne pritisnite sočasno.
AVONEX should be administered with caution to patients with previous or current depressive disorders, in particular to those with antecedents of suicidal ideation (see section 4.3). 
Previdnost pri dajanju zdravila AVONEX je potrebna pri bolnikih s preteklimi ali trenutno prisotnimi depresivnimi motnjami, zlasti tistimi, ki so povezane s samomorilnimi nagnjenji (glejte poglavje 4.3).
Prompt treatment of nephrotic syndrome is required and discontinuation of treatment with AVONEX should be considered. 
Zdravljenje nefrotskega sindroma je potrebno hitro začeti in razmisliti je potrebno o prenehanju zdravljenja z zdravilom AVONEX.
It is for a single use only. 
Primeren je samo za enkratno uporabo.
Side effects seen in clinical trials 
Neželeni učinki, opaženi v kliničnih preskušanjih
Interferons have been reported to reduce the activity of hepatic cytochrome P450-dependent enzymes in humans and animals. 
Podatki kažejo, da interferoni zmanjšujejo aktivnost encimov, odvisnih od jetrnega citokroma P450, pri ljudeh in živalih.
Infections and infestations not known injection site abscess1 
Infekcijske in parazitske bolezni neznana absces na mestu injiciranja1
If you use alcohol wipes, hold one on the injection site. 
Če uporabljate alkoholno krpico, jo držite na mestu vboda.
Tell your doctor as they may be signs of a possible kidney problem. 
To povejte zdravniku, saj so to lahko znaki težav z ledvicami.
The estimated risk of a second event was 50% in three years and 39% in two years in the placebo group and 35% (three years) and 21% (two years) in the AVONEX group. 
Ocenjeno tveganje drugega dogodka je bilo 50 % v treh letih in 39 % v dveh letih za bolnike, zdravljene s placebom, in 35 % (tri leta) ter
If you have been told to gradually increase your dose of Avonex, you may need to use an Avostartclip titration kit provided by your doctor. 
Če vam je bilo naročeno, da postopoma povečujete svoj odmerek zdravila Avonex, boste morda morali uporabiti komplet za titriranje Avostartclip, ki vam ga bo priskrbel zdravnik.
These include MHC Class I, Mx protein, 2' / 5'-oligoadenylate synthetase, β2-microglobulin, and neopterin. 
I, protein Mx, 2' / 5' - oligoadenilat ligazo, β2 mikroglobulin in neopterin.
Where to inject 
Kam injicirati
The instructions on how to inject yourself are at the end of this leaflet (see section 7, How to inject AVONEX). 
Navodila za injiciranje zdravila so na koncu teh navodil (glejte poglavje 7, Kako injicirati zdravilo AVONEX).
Disability progression was measured as an increase in the Expanded Disability Status Scale (EDSS) of 1.0 point, sustained for at least six months. 
Napredovanje prizadetosti se je merilo kot dvig na razširjeni lestvici prizadetosti (EDSS) za 1,0 točke.
5 Check the liquid 
5 Preverite tekočino.
10 seconds. 
1,0 točke.
Avonex and allergic reactions. 
Zdravilo Avonex in alergijske reakcije.
Avonex can be used during breast-feeding. 
Zdravilo Avonex se lahko uporablja med dojenjem.
• Firmly press the body of the pen down onto the skin to release the safety lock. 
• Čvrsto pritisnite ohišje napolnjenega injekcijskega peresnika na kožo, da sprostite varnostno zaporo.
B. Preparing the injection 
B. Priprava injekcije
- Blood clots in the small blood vessels that can affect your kidneys (thrombotic thrombocytopenic purpura or haemolytic uremic syndrome). 
- Krvni strdki v majhnih krvnih žilah, ki lahko vplivajo na delovanje ledvic (trombotična trombocitopenična purpura ali hemolitično-uremični sindrom).
Your doctor will tell you how long you need to keep using Avonex. 
Zdravnik vam bo povedal, kako dolgo morate uporabljati zdravilo Avonex.
As you keep using your injections, the flu-like symptoms gradually decrease. 
Z nadaljevanjem uporabe injekcij postajajo gripi podobni simptomi postopoma blažji.
If you have a preferred day for using Avonex, talk to your doctor about managing the dose, to get back to your preferred day. 
Če imate dan, na katerega najraje uporabljate zdravilo Avonex, se z zdravnikom pogovorite o načinu odmerjanja, ki bi omogočil vrnitev na dan, ki ste si ga določili.
Flu-like symptoms associated with AVONEX therapy may prove stressful to patients with underlying cardiac conditions. 
Gripi podobni simptomi, ki so povezani z zdravljenjem z zdravilom AVONEX, so lahko stresni za bolnike s srčnimi boleznimi.
The injection site should be varied each week. 
Mesto injiciranje je potrebno zamenjati vsak teden.
Flu-like symptoms tend to be most prominent at the initiation of therapy and decrease in frequency with continued treatment. 
Gripi podobni simptomi so običajno najbolj izraženi na začetku zdravljenja, z nadaljnjim zdravljenjem pa njihova pogostnost upada.
Psychiatric disorders common not known depression (see section 4.4), insomnia suicide, psychosis, anxiety, confusion, emotional lability 
Psihiatrične motnje pogosti neznana depresija (glejte poglavje 4.4), nespečnost samomor, psihoza, anksioznost, zmedenost,
The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal. 
C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z ZDRAVILOM Zahteve glede predložitve rednega posodobljenega poročila o varnosti zdravila za to zdravilo so določene v seznamu referenčnih datumov EU (seznamu EURD), opredeljenem v členu 107c(7)
The right hand pages have the information you will need to use Avonex Pen properly. 
Strani na desni strani vsebujejo informacije, ki jih boste potrebovali za pravilno uporabo svojega napolnjenega injekcijskega peresnika Avonex Pen.
• Continue to hold the pen on your skin and count slowly for a full 
• Še naprej držite napolnjen injekcijski peresnik na kožo in počasi štejte do polnih 10 sekund.
Endocrine disorders not known hypothyroidism, hyperthyroidism 
Bolezni endokrinega sistema neznana hipotiroidizem, hipertiroidizem
The pharmacokinetic profile of AVONEX has been investigated indirectly with an assay that measures interferon antiviral activity. 
Farmakokinetični profil zdravila AVONEX je bil preučen posredno, z analizo, ki je merila protivirusno aktivnost interferonov.
Your pack of Avonex already includes a needle for injection. 
Vaš zavoj zdravila Avonex že vsebuje injekcijsko iglo.
This might happen several weeks to several years after starting Avonex. 
To se lahko pojavi nekaj tednov do nekaj let po začetku zdravljenja z zdravilom Avonex.
Side effects seen in clinical trials. 
Neželeni učinki, opaženi v kliničnih preskušanjih.
If you have problems handling the syringe, talk to your doctor about using a syringe grip. 
Če imate težave pri rokovanju z injekcijsko brizgo, se pogovorite z zdravnikom glede uporabe ročaja za injekcijsko brizgo.
There are more details on how to inject using the Avonex Pen: In the fold-out section at the back of this leaflet. 
Več podrobnosti o injiciranju z napolnjenim injekcijskim peresnikom Avonex Pen: v zloženem delu na hrbtni strani tega navodila.
Treatment should be initiated under supervision of a physician experienced in the treatment of the disease. 
4.2 Odmerjanje in način uporabe Zdravljenje naj se začne pod nadzorom zdravnika, ki ima izkušnje z zdravljenjem te bolezni.
If you miss an injection 
Če ste pozabili injicirati
Effects of the injection 
Učinki injekcije
muscle spasticity, hypoesthesia neurological symptoms, syncope3, hypertonia, dizziness, paraesthesia, seizures, migraine 
spastičnost mišic, hipestezija nevrološki simptomi, sinkopa3, hipertonija, omotica, parestezije, napadi, migrena
Make sure the windows of the pen are visible. 
Prepričajte se, da so okna napolnjenega injekcijskega peresnika vidna.
Patients should be advised to immediately report any symptoms of depression and/or suicidal ideation to their prescribing physician. 
Bolnikom, ki se zdravijo, naročite, naj zdravnika takoj obvestijo o vseh morebitnih simptomih depresije in/ali samomorilnih mislih.
AVONEX is indicated for the treatment of 
Zdravilo AVONEX je indicirano za zdravljenje
If you are new to Avonex, your doctor may advise you to gradually increase your dose so that you can adjust to the effects of Avonex before taking the full dose. 
V kolikor še niste uporabljali zdravila Avonex, vam lahko zdravnik svetuje, da postopoma povečujete vaš odmerek, zato da se lahko, preden uporabite celotni odmerek, navadite na učinke zdravila Avonex.
Avonex is made by: 
Zdravilo Avonex izdeluje:
Multiple sclerosis is linked to nerve (brain or spinal cord) damage. 
Kako deluje zdravilo AVONEX Multipla skleroza je povezana s poškodbo živcev (možganski živci ali živci hrbtenjače).
Nephrotic Syndrome: Cases of nephrotic syndrome with different underlying nephropathies including collapsing focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranoproliferative glomerulonephritis (MPGN) and membranous glomerulopathy (MGN) have been reported during treatment with interferon-beta products. 
Nefrotski sindrom: Med zdravljenjem z zdravili, ki vsebujejo interferon beta, so poročali o primerih nefrotskega sindroma z različnimi osnovnimi nefropatijami, vključno s kolapsno fokalno segmentno glomerulosklerozo (FSGS, collapsing focal segmental glomerulosclerosis), boleznijo minimalnih sprememb (MCD, minimal change disease), membranoproliferativnim glomerulonefritisom (MPGN, membranoproliferative glomerulonephritis) in membransko glomerulopatijo (MGN, membranous glomerulopathy).
Each syringe is packed in a sealed plastic tray, which also contains one injection needle for intramuscular use. 
Vsaka injekcijska brizga je zapakirana v zaprtem plastičnem ovoju, ki vsebuje tudi eno injekcijsko iglo za intramuskularno uporabo.
Transient episodes of hypertonia and/or severe muscular weakness that prevent voluntary movements may occur at any time during treatment. 
napadi hipertonije in/ali hude mišične šibkosti, ki preprečujejo hotne gibe.
A double-blind randomised dose comparison study of 802 relapsing MS patients (AVONEX 30 micrograms n=402, AVONEX 60 micrograms n=400) has shown no statistically significant differences or trends between the 30 micrograms and the 60 micrograms doses of AVONEX in clinical and general MRI parameters. 
Randomizirana, dvojno slepa študija primerjave odmerkov, pri kateri sta sodelovala 802 bolnika s ponavljajočo se MS (zdravilo AVONEX 30 mikrogramov n=402, zdravilo AVONEX 60 mikrogramov n=400) pri kliničnih in splošnih MRI parametrih ni pokazala statistično pomembnih razlik ali trendov med 30 mikrogramskimi in 60 mikrogramskimi odmerki zdravila AVONEX.
Each pre-filled syringe of AVONEX contains a single dose only. 
Vsaka napolnjena injekcijska brizga zdravila AVONEX vsebuje samo en odmerek.
Patients with an EDSS of 1.0 to 3.5 at entry were included in the clinical trial. 
V klinično študijo so bili vključeni bolniki, ki so pri vstopu v študijo imeli EDSS od 1 do 3,5.
If you have decided to start treatment with Avonex, your doctor may provide you with an Avostartclip titration kit. 
V kolikor ste se odločili za pričetek zdravljenja z zdravilom Avonex, vam lahko zdravnik priskrbi komplet za titriranje Avostartclip.
4 Check the injector shield is extended correctly 
4 Preverite, ali je zaščita injektorja pravilno razširjena.
There are more details on how to inject Avonex at the end of this leaflet. 
Več podrobnosti o injiciranju zdravila Avonex je na koncu tega navodila.
• Firmly press until you hear a “click” to seal the needle. 
• Čvrsto pritiskajte, dokler ne zaslišite klika, ki pomeni, da je igla zaprta.
The highest incidence of adverse reactions associated with AVONEX therapy is related to flu-like symptoms. 
Največja incidenca neželenih pojavov v zvezi s terapijo z zdravilom AVONEX je povezana z gripi podobnimi simptomi.
Check the liquid in the syringe 
Preverite tekočino v injekcijski brizgi
Your doctor may provide you with an Avostartclip titration kit which enables you to gradually increase your dose at the start of treatment to help limit flu-like symptoms. 
Zdravnik vam lahko priskrbi komplet za titriranje Avostartclip, ki omogoča postopno povečevanje odmerka na začetku zdravljenja, kar pomaga pri blaženju gripi podobnih simptomov.
Some people find that after using Avonex Pen, they feel like they have flu. 
Nekateri ljudje se po uporabi napolnjenega injekcijskega peresnika Avonex Pen počutijo, kot da imajo gripo.
Do not use AVONEX: 
Ne uporabljajte zdravila AVONEX:
Blood and lymphatic system disorders not known rare pancytopenia, thrombocytopenia thrombotic microangiopathy including thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome* 
Bolezni krvi in limfatičnega sistema neznana redki pancitopenija, trombocitopenija trombotična mikroangiopatija, vključno s trombotično trombocitopenično purpuro/hemolitično-uremičnim sindromom*
Avonex and allergic reactions 
Zdravilo Avonex in alergijske reakcije
Do NOT use Avonex if you notice: 
NE uporabljajte zdravila Avonex, če opazite:
Press the needle onto the syringe. 
Iglo potisnite na injekcijsko brizgo.
C. Giving the injection 
C. Dajanje injekcije
Common (≥1/100 to <1/10 patient-years); 
Pogosti (≥1/100 do <1/10 bolnikov-let);
Avonex works best when you use it at the same time, once a week, on a regular basis. 
Učinki zdravila Avonex so najboljši, če ga uporabljate redno, ob istem času, enkrat tedensko.
Each syringe is packed in a sealed plastic tray. 
Vsaka injekcijska brizga je zapakirana v zapečatenem plastičnem ovoju.
In a post-hoc analysis, those patients with a baseline MRI with at least one Gd-enhancing lesion and nine T2 lesions had a two-year risk of suffering a second event of 56% in the placebo group and 21% in the AVONEX treatment group. 
V post hoc analizi se je pri bolnikih z osnovno mejo MRI z vsaj enim Gd-stopnjevanjem poškodb in devetimi T2 poškodbami pokazala 56 % možnost drugega napada pri bolnikih, zdravljenih s placebom, in 21 % možnost drugega napada pri bolnikih, zdravljenih z zdravilom AVONEX.
Inside the back cover there's a fold-out chart with everything you need to make injections with your Avonex Pen. 
Znotraj hrbtne platnice je zložljiva tabela z vsem, kar potrebujete, da s svojim napolnjenim injekcijskim peresnikom Avonex Pen izvedete injiciranje.
Blood clots in the small blood vessels may occur during your treatment. 
Med zdravljenjem se lahko pojavijo krvni strdki v majhnih krvnih žilah.
Renal and urinary disorders rare nephrotic syndrome, glomerulosclerosis (see section 4.4 ‘special warnings and precautions') 
Bolezni sečil redki nefrotski sindrom, glomeruloskleroza (glejte poglavje 4.4, Posebna opozorila in previdnostni ukrepi)
Avonex Pens are provided in packs of four or twelve for one or three months of injections. 
Napolnjeni injekcijski peresniki Avonex Pen so na voljo v pakiranjih po štiri ali dvanajst za eno- ali trimesečno zalogo injekcij.
If you are using a syringe that has an Avostartclip attached, you will receive a lower dose of Avonex. 
V kolikor uporabljate injekcijsko brizgo s pritrjenim pripomočkom Avostartclip, boste prejeli manjši odmerek zdravila Avonex.
What AVONEX PEN looks like and contents of the pack 
Izgled zdravila AVONEX PEN in vsebina pakiranja
Some people find that after injecting Avonex, they feel like they have flu. 
Nekateri ljudje imajo po injiciranju zdravila Avonex občutek, kot da imajo gripo.
For further details on use, speak with your doctor. 
Za nadaljnje informacije o uporabi se posvetujte z zdravnikom.
Respiratory, thoracic and mediastinal disorders common rare not known rhinorrhoea dyspnoea pulmonary arterial hypertension┼ 
Bolezni dihal, prsnega koša in mediastinalnega prostora pogosti redki neznana rinoreja dispneja pljučna arterijska hipertenzija
If you have trouble handling the Avonex Pen, ask your doctor who may be able to help. 
Če imate težave z uporabo napolnjenega injekcijskega peresnika Avonex Pen, se posvetujte z zdravnikom, ki vam bo lahko pomagal.
The AVOSTARTCLIP titration kit is designed for use with the pre-filled syringe only. 
Komplet za titriranje AVOSTARTCLIP je zasnovan samo za uporabo z napolnjeno injekcijsko brizgo.
The effects of AVONEX in the treatment of MS were also demonstrated in a randomised double-blind study performed with 383 patients (AVONEX n=193, placebo n=190) with a single demyelinating event associated with at least two compatible brain MRI lesions. 
Učinki zdravila AVONEX pri zdravljenju MS so bili prikazani tudi na randomizirani, dvojno slepi študiji, opravljeni na 383 bolnikih (zdravilo AVONEX n=193, placebo n=190), z enim demielinizirajočim napadom, povezanim z vsaj dvema kompatibilnima možganskima MRI poškodbama.
- Pulmonary arterial hypertension: A disease of severe narrowing of the blood vessels in the lungs resulting in high blood pressure in the blood vessels that carry blood from the heart to the lungs. 
- spremembe v rezultatih testov, vključno s spremembami testov delovanja jeter, - pljučna arterijska hipertenzija: bolezen, ki povzroči hudo zoženje krvnih žil v pljučih, katerega posledica je visok krvni tlak v žilah, po katerih kri teče iz srca v pljuča.
Tip: The best area is the upper, outer thigh. 
Nasvet: Najboljši predel je zgornji, zunanji del stegna.
Limited published data suggest that the safety profile in adolescents from 12 to 16 years of age receiving AVONEX 30 micrograms IM once per week is similar to that seen in adults. 
Pediatrična populacija Malo objavljenih podatkov kaže, da je varnostni profil pri mladostnikih, starih od 12 do 16 let, ki dobivajo zdravilo AVONEX 30 mikrogramov i.m.
Cardiac disorders not known cardiomyopathy, congestive heart failure (see section 4.4), palpitations, arrhythmia, tachycardia 
Srčne bolezni neznana kardiomiopatija, kongestivno srčno popuščanje (glejte poglavje 4.4), palpitacije, aritmija, tahikardija
Treatment with Avonex can help to prevent you from getting worse, although it will not cure MS. 
Zdravljenje z zdravilom Avonex lahko prepreči poslabšanje multiple skleroze, vendar je ne ozdravi.
Natural interferon beta and AVONEX (interferon beta-1a) are glycosylated and have a single N-linked complex carbohydrate moiety. 
Naravni interferon beta in zdravilo AVONEX (interferon beta-1a) sta glikozilirana in imata en N-vezani kompleksen ogljikohidratni del.
Do not stop your Avonex treatment without speaking to your neurologist. 
Ne prenehajte uporabljati zdravila Avonex, ne da se pogovorite z nevrologom.
Caution should be used and close monitoring considered when administering AVONEX to patients with severe renal and hepatic failure and to patients with severe myelosuppression. 
Previdnost in natančno opazovanje sta potrebna pri dajanju zdravila AVONEX bolnikom z resnimi okvarami ledvic in jeter ter bolnikom z resno supresijo kostnega mozga.
• The plastic needle cover will “pop” off. 
• Plastični pokrovček igle se bo odlomil.
Store the AVONEX PEN in the inner carton in order to protect from light (see section 6.5). 
Napolnjen injekcijski peresnik AVONEX PEN shranjujte v notranji škatli za zagotovitev zaščite pred svetlobo (glejte poglavje 6.5).
What AVONEX is and what it is used for 2. 
Kaj je zdravilo AVONEX in za kaj ga uporabljamo 2.
Very common (≥1/10 patient-years); 
Zelo pogosti (≥1/10 bolnikov-let);
Do not twist it. 
Ne sučite ga.
Chronic Toxicity: In a 26-week repeated dose toxicity study in rhesus monkeys by intramuscular route once per week, administered in combination with another immunomodulating agent, an anti CD40 ligand monoclonal antibody, no immune response toward interferon beta-1a and no signs of toxicity were demonstrated. 
Kronična toksičnost: v 26-tedenski študiji toksičnosti s ponavljajočimi odmerki so opicam Rhesus enkrat tedensko intramuskularno dajali zdravilo, v kombinaciji z drugim imunomodulatorjem, anti
• Avonex is injected into a muscle, for example, the upper thigh muscle. 
• Zdravilo Avonex se injicira v mišico, na primer v zgornjo stegensko mišico.
1 Clean the injection site 
1 Očistite mesto injiciranja.
Thrombotic microangiopathy (TMA): Cases of thrombotic microangiopathy, manifested as thrombotic thrombocytopenic purpura (TTP) or haemolytic uraemic syndrome (HUS), including fatal cases, have been reported with interferon beta products. 
Trombotična mikroangiopatija (TMA): Pri zdravilih z interferonom beta so poročali o primerih trombotične mikroangiopatije, ki se je izrazila kot trombotična trombocitopenična purpura (TTP) ali hemolitično-uremični sindrom (HUS), vključno s smrtnimi primeri.
Musculoskeletal and connective tissue disorders common not known muscle cramp, neck pain, myalgia2, arthralgia, pain in extremity, back pain, muscle stiffness, musculoskeletal stiffness systemic lupus erythematosus, muscle weakness, arthritis 
Bolezni mišično-skeletnega sistema in vezivnega tkiva pogosti neznana mišični krči, bolečine v vratu, mialgija2, artralgija, bolečine v udih, bolečine v hrbtu, mišična togost, mišično-skeletna togost sistemski eritematozni lupus, mišična oslabelost, artritis
Use a different injection site each week 
Vsak teden uporabite drugo mesto injiciranja.
Tip: Continue to hold the pen firmly on the skin. 
Nasvet: še naprej čvrsto držite napolnjen injekcijski peresnik na kožo.
Do not lift the pen away from your skin. 
Injekcijskega peresnika ne dvignite s kože.