natgillin/translations-raw huggingface dataset:
Treatment duration was five consecutive days in all studies. 
V vseh študijah je bilo trajanje zdravljenja 5 zaporednih dni.
Hungary V.M.D. 
Madžarska V.M.D.
To support the efficacy of the products concerned altogether 11 original proprietary studies were submitted by the Applicants/Marketing Authorisation Holders including 3 experimental infection studies and 8 clinical field studies. 
V podporo učinkovitosti zadevnih zdravil so predlagatelji/imetniki dovoljenj za promet z zdravilom predložili enajst izvirnih lastniških študij, ki so obsegale tri študije z eksperimentalno okužbo in osem kliničnih terenskih študij.
The data packages submitted consist of bibliographic data available in the public domain and proprietary data. 
Predloženi sklopi podatkov obsegajo bibliografske podatke, ki so javno dostopni, in pravno zaščitene podatke.
In some studies the residue depletion kinetics of doxycycline were not demonstrated because tissue residues were detected at one or two time points after drug withdrawal only. 
V nekaterih študijah kinetika izločanja ostankov doksiciklina ni bila dokazana, ker so ostanke v tkivu zaznali le enkrat ali dvakrat po prekinitvi uporabe zdravila.
The most favourable results were obtained at the highest dose tested, i.e. 1000 ppm corresponding to 196 mg/kg body weight for 5 days. 
Najugodnejše rezultate so dobili pri največjem preskušenem odmerku, tj. 1 000 ppm, kar ustreza 196 mg/kg telesne mase za 5 dni.
Nine responses were with generic dossiers developed in accordance with the Article 13 of Directive 2001/82/EC. 
Devet odgovorov je vsebovalo generično dokumentacijo, ki je bila pripravljena v skladu členom 13 Direktive 2001/82/ES.
There was no documented evidence indicating a new risk associated with the use of doxycycline in poultry in relation to lack of efficacy. 
Ni bilo dokumentiranih dokazov o novem tveganju, povezanem z uporabo doksiciklina pri perutnini v zvezi z neučinkovitostjo.
Riudoms 43330 (Tarragona) SPAIN 
Riudoms 43330 (Tarragona) ŠPANIJA
Therefore the product should be used for the treatment of infections caused by E. coli only after susceptibility testing has been carried out. 
Zato je treba zdravilo uporabljati za zdravljenje okužb z E. coli šele po izvedenem testu občutljivosti.
Despite the deficiencies in the submitted studies and lack of data for some indications and dosages on the basis of well established use and the lack of any new pharmacovigilance information in relation to lack of efficacy it can be concluded that the current dosages and indications for the doxycycline containing products can be considered safe and effective. 
Kljub pomanjkljivostim predloženih študij, pomanjkanju podatkov za določene indikacije in odmerke na podlagi dobro uveljavljene rabe ter odsotnosti novih farmakovigilančnih podatkov v zvezi z neučinkovitostjo se lahko zaključi, da so trenutni odmerki in indikacije za zdravila, ki vsebujejo doksiciklin, varni in učinkoviti.
Bulgaria Farma Sis OOD 4 San Stefano Str. 
Bolgarija Farma Sis OOD 4 San Stefano Str.
As regards Escherichia coli infections, three publications of experimental model studies (George et al., 19772; Goren et al., 19883, Velkers et al., 20054) and one clinical efficacy study were presented. 
V zvezi z okužbami z Escherichia coli so bile predložene tri objave študij eksperimentalnih modelov (George et al., 19772; Goren et al., 19883, Velkers et al., 20054) in ena klinična študija učinkovitosti.
However the article of George et al. (1977)2 does not include sufficient information (body weights and water consumption) to calculate the daily actual dose intake of the study animals. 
Vendar v prispevku George et al. (1977)2 ni dovolj informacij (glede telesne mase in porabe vode) za izračun dejanskega dnevnega vnesenega odmerka pri proučevanih živalih.
Nutri-Biomed Hellas LTD 1,V.Hugo &Chlois Metamorfosi Attikis 14452 Athens GREECE 
Nutri-Biomed Hellas LTD 1,V.Hugo &Chlois Metamorfosi Attikis 14452 Athens GRČIJA
Romania PHARMATEKA BT 1046 Budapest 
Romunija PHARMATEKA BT 1046 Budapest
Trei Bio pharmaceutical division, Industria Italiana Integratori Trei 
Slovaška Trei Bio pharmaceutical division, Industria Italiana Integratori Trei
Arendonk BELGIUM 
Arendonk BELGIJA
POL.IND.MECANOV A, NAVES 27-28 25191 LLEIDA SPAIN 
POL.IND.MECANOV A, NAVES 27-28 25191 LLEIDA ŠPANIJA
2370 Arendonk BELGIUM 
2370 Arendonk BELGIJA
It is primiraly a bacteriostatic antibiotic and has its main mechanism of action on inhibition of protein synthesis. 
Doksiciklin je predvsem bakteriostatičen antibiotik, njegov glavni mehanizem delovanja pa je zaviranje sinteze beljakovin.
Doxycycline is a tetracycline derivative with uses similar to those of tetracycline. 
Doksiciklin je tetraciklinski derivat, ki ga uporabljamo podobno kot tetraciklin.
Laboratoires Biove 3 rue de Lorraine 62510 Arques FRANCE 
Francija Laboratoires Biove 3 rue de Lorraine 62510 Arques
1093 Budapest HUNGARY 
1093 Budapest MADŽARSKA
In particular, information about the study conditions (medical history of the study site, housing and feeding conditions, light/dark cycle) as well as the treatment schedule (medication ad libitum for 24 hours/ pulse medication) was missing or very limited. 
Večinoma so manjkale informacije o pogojih študije (medicinska anamneza na mestu študije, pogoji bivanja in krmljenja, ciklusi svetlobe/teme) ter urnik zdravljenja (zdravila ad libitum za 24 ur/pulzno zdravljenje) ali pa so bile te zelo omejene.
PARCELA409-410 25191 Lérida SPAIN 
PARCELA409-410 25191 Lérida ŠPANIJA
List of the names, pharmaceutical forms, strengths of the veterinary medicinal products, animal species, route of administration, indications / withdrawal periods and applicants / marketing authorisation holders in the Member States 
SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI, ŽIVALSKIH VRST, POTI UPORABE, INDIKACIJ/KARENC IN PREDLAGATELJEV/IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
mg/kg/day (pigs) 
mg/kg/dan (prašiči)
However the publication does not provide sufficient information to calculate the actual dose intake of the study animals. 
Vendar objava ne vsebuje dovolj informacij za izračun dejanskega vnosa odmerka pri proučevanih živalih.
10 rue Clement Ader 
Francija Noe 10 rue Clement Ader
Tierarzneimittel Gesellschaft m.b.H.Kaplanstraß e 10 AT 
Avstrija Chevita Tierarzneimittel Gesellschaft m.b.H.Kaplanstraß e 10 AT
However, the publication did not include the necessary information to derive a daily actual dose intake of the study birds. 
Vendar v objavo niso vključili informacij, potrebnih za izpeljavo dnevnega dejanskega vnesenega odmerka pri proučevanih pticah.
47100 Forli ITALY 
47100 Forli ITALIJA
Via Augusta, 302 08017 Barcelona SPAIN 
Via Augusta, 302 08017 Barcelona ŠPANIJA
As regards Pasteurella multocida infection, two experimental studies in broiler chickens were presented, i.e. one publication (Semjen et al., (1998)1, and one proprietary study. 
V zvezi z okužbo s Pasteurella multocida sta bili predstavljeni dve eksperimentalni študiji pri pitovnih piščancih, tj. ena objava (Semjen et al., (1998))1 in ena lastniška študija.
As regards P. multocida infections, results of an experimental model study indicate a treatment dose of 10 mg/kg body weight for 4 or 5 days, but no confirmatory clinical data obtained under commercial conditions has been made available. 
V zvezi z okužbami s P. multocida rezultati študije na poskusnih modelih kažejo terapevtski odmerek 10 mg/kg telesne mase 4 ali 5 dni, vendar potrditveni klinični podatki v komercialnih okoliščinah niso bili na voljo.
Barcelona, 411 08620 San Vicens del Horts SPAIN 
Barcelona, 411 08620 San Vicens del Horts ŠPANIJA
At this dose levels mean plasma doxycycline levels of 3.6 µg/ml (measured on the 2nd treatment day were achieved. 
Pri tej koncentraciji so povprečne ravni doksiciklina v plazmi 3,6 µg/ml (izmerjeno 2. dan zdravljenja).
Hungary Kon-Pharma GmbH. 
Madžarska Kon-Pharma GmbH.
Hungary Phylaxia Pharma Zrt. 
Madžarska Phylaxia Pharma Zrt.
Therefore, CVMP recommends that the product literature for all concerned products in this procedure should include appropriate prudent use statements in line with what is recommended in the CVMP Guideline on the SPC for antimicrobials (EMEA/CVMP/SAGAM/383441/2005)8 and information on correct administration. 
CVMP zato priporoča, da literatura o vseh zdravilih, ki jih zadeva ta postopek, vsebuje ustrezne izjave o preudarni uporabi v skladu s priporočili Smernice CVMP o povzetku glavnih značilnosti protimikrobnih zdravil (EMEA/CVMP/SAGAM/383441/2005)8 in informacije o pravilni uporabi.
71 08503 GURB - VIC SPAIN 
71 08503 GURB - VIC ŠPANIJA
Armazém nº 21 Casal do Bagulho Granja de Alpriate 2625-607 Vialonga PORTUGAL 
Casal do Bagulho Granja de Alpriate 2625-607 Vialonga PORTUGALSKA
Alternatively, the concentrated solution can be used in a proportional water medicator. 
Drugače se lahko koncentrirana raztopina uporabi v napravi za proporcionalno vmešavanje zdravil.
Romania s.c. romvac company s.a.Şos. 
Romunija s.c. romvac company s.a.Şos.
Bucharest ROMANIA 
Bucharest ROMUNIJA
The use of doxycycline hyclate for all claimed indications in chickens as well as the use of doxycycline hyclate in other poultry species was considered well-established. 
Uporaba doksiciklinijevega hiklata za vse predlagane indikacije pri piščancih ter uporaba doksiciklinijevega hiklata pri drugih vrstah perutnine se šteje za dobro uveljavljeno.
The daily doses administered to chickens ranged between 10.36 mg/kg body weight, 14.47 mg/kg body weight and 25 mg/kg body weight. 
Dnevni odmerki, uporabljeni pri piščancih, so bili v razponu med 10,36 mg/kg telesne mase, 14,47 mg/kg telesne mase in 25 mg/kg telesne mase.
Zoovetvaru uusaru 5 
Estonija Zoovetvaru uusaru 5
Pharmagal s.r.o., Murgašova 5, 949 01 Nitra, Slovak Republic 
Pharmagal s.r.o., Murgašova 5, 949 01 Nitra, Slovaška
Different product formulations were used in the studies containing, doxycycline hyclate/hydrochloride at different concentrations; almost all included acidifiers in the formulation (usually citric acid). 
V študijah so bile uporabljene različne formulacije zdravil, ki so vsebovale doksiciklinijev hiklat/doksiciklinijev hidroklorid v različnih koncentracijah; v skoraj vseh so bila vključena sredstva za zakisanje (po navadi citronska kislina).
Via W. Tobagi n.7 20068 Peschiera Borromeo (Milano) ITALY 
Via W. Tobagi n.7 20068 Peschiera Borromeo (Milano) ITALIJA
The study published by Goren et al. (1988)3 was designed as a dose titration study with doxycycline administered at dosages of 25-1000 ppm in drinking water for 5 consecutive days. 
Študija, ki so jo objavili Goren et al. (1988)3, je bila zasnovana kot študija titracije odmerka, v kateri so doksiciklin dajali 5 zaporednih dni v pitno vodo v razponu odmerkov 25-1 000 ppm.
In the proprietary study, diarrhoea was one of the main clinical symptoms observed in infected untreated animals, which is not considered typical for Pasteurellosis. 
V lastniški študiji je bila eden od glavnih kliničnih simptomov, ki so jih spremljali pri okuženih nezdravljenih živalih, driska, ki pa se ne šteje kot značilen simptom za pasteurelozo.
Czech republic 
Češka republika
However there was no documented evidence for lack of efficacy in the treatment of respiratory infection associated with Mycoplasma gallisepticum with any other of the approved dosage regimens (10-25 mg/kg body weight). 
Ni pa dokumentiranih dokazov o neučinkovitosti pri zdravljenju okužb dihal z Mycoplasma gallisepticum pri nobenem od odobrenih režimov odmerjanja (10-25 mg/kg telesne mase)
DOXYVIT 40% per 3-6 L of drinking water 
DOXYVIT 40 % na 3-6 l pitne vode
One of these studies serve as the confirmatory evidence for the efficacy of this target dose, based on objective parameters such as a significant reduction of the percentage of animals with pathological lesions and total lesion scores typical of the disease and significant reduction in the recovery rate of M. gallisepticum after treatment. 
Ena od teh študij velja kot potrditveni dokaz za učinkovitost tega ciljnega odmerka na podlagi objektivnih parametrov, kot so bistveno zmanjšanja odstotka živali s patološkimi lezijami in skupnim točkovanjem lezij, ki je značilno za bolezen, ter bistveno zmanjšanje stopnje izolacije M. gallisepticum po zdravljenju.
Comparison of these infection studies that investigate Colibacillosis was problematic due to considerable differences in the experimental conditions such as the use of different challenge strains and infectious dose levels, different time of treatment initiation, and differences in the chickens (age, weight, and breed) used. 
Primerjava omenjenih študij okužb, v katerih so raziskovali kolibacilozo, je težavna zaradi bistvenih razlik v eksperimentalnih pogojih, kot je uporaba različnih izzivnih sevov in ravni infektivnega odmerka, različnih časov uvedbe zdravljenja in razlik v uporabljenih piščancih (starost, masa, pasma).
The United Kingdom expressed concerns that differences in the posology, dose range, duration of treatment and withdrawal periods established across the European Union for all strengths of water soluble powders and oral solutions containing doxycycline hyclate indicated for use in poultry and intended for administration via drinking water may present a potential serious risk to both animal health and human health, and requested the CVMP to give its opinion on the matter. 
Združeno kraljestvo je izrazilo zadržek, da lahko razlike v odmerjanju, razponih odmerkov, trajanju zdravljenja in karencah, ki veljajo v Evropski uniji za vse jakosti vodotopnih praškov in peroralnih raztopin, ki vsebujejo doksiciklinijev hiklat in so indicirani za uporabo pri perutnini ter za dajanje s pitno vodo, pomenijo možno resno tveganje za zdravje živali in ljudi, zato je zaprosilo CVMP, da poda mnenje glede te zadeve.
Via Colleoni n.15 20041 Agrate Brianza (Milano) ITALY 
Via Colleoni n.15 20041 Agrate Brianza (Milano) ITALIJA
While the data submitted by Applicants/Marketing Authorisation Holders failed to provide sufficient documented evidence to support the established doses for all other indications and species, there was, however, no new information indicating any new risk associated with the use of doxycycline in poultry in relation to lack of efficacy. 
Čeprav podatki, ki so jih predložili predlagatelji/imetniki dovoljenja za promet z zdravilom, niso vsebovali dovolj dokazov v podporo uveljavljenim odmerkom za vse druge indikacije in živalske vrste, ni novih informacij, ki bi kazale novo tveganje, povezano z uporabo doksiciklina pri perutnini v zvezi z neučinkovitostjo.
5530 AD Bladel THE 
5530 AD Bladel NIZOZEMSKA
Sogeval Laboratoires 200 route De Mayenne 53 022 Laval Cedex FRANCE 
Laboratoires 200 route De Mayenne 53 022 Laval Cedex FRANCIJA
A high resistance rate of E. coli, isolated from chickens, against tetracyclines has been documented. 
Ugotovljena je visoka stopnja odpornosti E. coli, izolirane iz piščancev, proti tetraciklinom.
All tetracyclines have a broad spectrum of activity which include Gram-positive and Gram-negative bacteria, chlamydias, rickettsias, mycoplasmas and spirochaetes. 
Vsi tetraciklini imajo širok spekter aktivnosti, ki vključujejo grampozitivne in gramnegativne bakterije, klamidije, rikecije, mikoplazme in spirohete.
Romania S.C. Crida pharm s.r.l 
Romunija S.C. Crida pharm s.r.l
The data submitted for Chlamydiosis were inconclusive and therefore there was insufficient information to support this indication both in chickens and other target species for the currently approved products that are within the scope of this referral procedure. 
Podatki, predloženi za klamidiozo, so bili neprepričljivi, zato je bilo premalo informacij v podporo tej indikaciji pri piščancih in drugih ciljnih živalskih vrstah za trenutno odobrena zdravila, ki so zajeta v obseg tega napotitvenega postopka.
With regard to the E. coli infections in poultry the data submitted was not sufficient. 
Podatki, predloženi v zvezi z okužbami z E. coli pri perutnini, so bili nezadostni.
= .... mg [product name] per l drinking water 
= .... mg zdravila [ime zdravila] na l pitne vode
As eradication of the target pathogens may not be achieved, medication should therefore be combined with good management practices, e.g. good hygiene, proper ventilation, no overstocking. 
Ker izkoreninjenja ciljnih bolezenskih povzročiteljev morda ni možno doseči, je treba zdravilo kombinirati z dobro prakso obvladovanja bolezni, npr. ustrezno higieno, ustreznim prezračevanjem, preprečevanjem naselitve prevelikega števila živali na enoto.
Antimicrobial efficacy as evident from recovery rate of O. rhinotracheale was not confirmed. 
Protimikrobna učinkovitost, ki so jo dokazovali s stopnjo izolacije O. rhinotracheale, ni bila potrjena.
Scientific conclusions and grounds for amendment of the summary of product characteristics 
ZNANSTVENI ZAKLJUČKI IN PODLAGA ZA DOPOLNILO POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA
Meat - 4 days 
meso - 4 dni
Doxycycline was also shown to be superior to chlortetracycline used as positive control. 
Dokazali so, da je doksiciklin boljši od klortetraciklina, ki se je uporabil kot pozitivna kontrola.
CHEMO IBERICA, S.A. Gran Via Carlos III, 98 7ª Edificio Trade 08028 Barcelona SPAIN 
CHEMO IBERICA, S.A. Gran Via Carlos III, 98 7ª Edificio Trade 08028 Barcelona ŠPANIJA
In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted. 
Koncentracijo v pitni vodi bo morda treba prilagoditi tako, da se doseže pravilni odmerek.
Romania PHYLAXIA PHARMA LTD 
Romunija PHYLAXIA PHARMA LTD
Nevertheless as P. multocida was shown to be susceptible to doxycycline with a MIC90 up to 2µg/ml and covered by pharmacokinetic/pharmacodynamic analysis, the inclusion of P. multocida infections in the indication for chickens appears justified. 
Ker pa je bilo dokazano, da je P. multocida občutljiva za doksiciklin z MIK 90 do 2 µg/ml in je bila zajeta v farmakokinetično/farmakodinamično analizo, se zdi vključitev okužb s P. multocida v indikacije za piščance utemeljena.
CEVA Saúde Animal -Produtos farmacêuticos e Imunológicos Lda. 
Portugalska CEVA Saúde Animal -Produtos farmacêuticos e Imunológicos
From the overall data submitted by the Applicants/Marketing Authorisation Holders only nineteen responses were with full dossiers developed in accordance with the Article 12(3) of Directive 2001/82/EC. 
Od vseh podatkov, ki so jih predložili predlagatelji/imetniki dovoljenj za promet z zdravili, je devetnajst odgovorov vsebovalo popolno dokumentacijo, ki je bila pripravljena v skladu členom 12(3) Direktive 2001/82/ES.
Amendments to be included in the relevant sections of the labelling 
DOPOLNILA, KI SE VKLJUČIJO V USTREZNA POGLAVJA OZNAČEVANJA
Therefore, the inclusion of appropriate standard prudent use statements in line with recommendations of the CVMP guideline on the SPC of Antimicrobials and information on correct administration of the products concerned in this referral procedure was considered appropriate; the CVMP has recommended the variation of the Marketing Authorisations and amendments of the relevant sections of the Summary of Product Characteristics, labelling and package leaflet to include as a minimum the information set out in Annex III for the water soluble powders and oral solutions containing doxycycline hyclate indicated for use in poultry and intended for administration via drinking as referred in Annex I of the Opinion. 
Zato se zdi primerno, da se vključijo ustrezne standardne izjave o preudarni rabi v skladu s priporočili Smernic CVMP o povzetku glavnih značilnosti protimikrobnih zdravil in podatkov o pravilni uporabi zdravil, ki jih zadeva ta postopek; je CVMP priporočil spremembo dovoljenj za promet z zdravilom in dopolnitev ustreznih poglavij povzetka glavnih značilnosti zdravila, označevanja in navodila za uporabo, da se vključijo vsaj tiste informacije, določene v Dodatku III za vodotopne praške in peroralne raztopine, ki vsebujejo doksiciklinijev hiklat in so indicirani za uporabo pri perutnini ter dajanju v pitno vodo, kakor je navedeno v Dodatku I mnenja.
It could be argued that doxycycline can be effectively used in the treatment of E. coli infections in broilers provided, however, that susceptibility to doxycycline is confirmed before initiation of treatment. 
Obstajajo utemeljitve, da se lahko doksiciklin učinkovito uporablja za zdravljenje okužb z E. coli pri pitovnih piščancih, vendar je treba pred uvedbo zdravljenja preveriti občutljivost za doksiciklin.
The residue depletion studies presented by the MAHs indicated that the statistical approach6 as recommended by the Committee was used for the establishment of withdrawal periods whenever possible. 
V študijah o izločanju ostankov, ki so jih predložili imetniki dovoljenj za promet z zdravili, so za določitev karenc - kadar je bilo možno - uporabili statistični pristop6 , kar priporoča Odbor.
Advice on correct administration 
NASVET O PRAVILNI UPORABI ZDRAVILA
Special warning(s) 
POSEBNO(A) OPOZORILO(A)
In the confirmatory phase, both the clinical and pathological response to artificial O. rhinotracheale infection was low in un-medicated controls. 
V potrditveni fazi je bil klinični in patološki odziv na umetno okužbo z O. rhinotracheale pri nezdravljenih živalih majhen.
In an experimental setting testing homeopathic medication in the treatment of Colibacillosis in broiler chickens, doxycycline was used for control (Velkers et al., 2005)4. 
V eksperimentalnem okolju so preverjali homeopatsko zdravilo za zdravljenje kolibaciloze pri pitovnih piščancih, za kontrolo pa so uporabili doksiciklin (Velkers et al., 2005)4.
42010 Rio Saliceto (Reggio Emilia) ITALY 
42010 Rio Saliceto (Reggio Emilia) ITALIJA
However, data of the pilot phase indicate that chickens at the highest infectious dose level, treated with doxycycline at a dose of 20 mg/kg per day for 4 days showed a significant reduction in air sac lesions compared to un-medicated controls. 
Vendar podatki iz pilotske faze kažejo, da so piščanci, ki so prejeli največji infektivni odmerek in so bili zdravljeni z odmerkom doksiciklina v višini 20 mg/kg dnevno 4 dni, izkazali pomembno zmanjšanje lezij zračnih vreč v primerjavi z živalmi, ki niso prejele zdravila.
Ornithrobacterium rhinotracheale infection. 
Ornithrobacterium rhinotracheale
Gran Via Carlos III, 98 7ª Edificio Trade 08028 Barcelona SPAIN 
Gran Via Carlos III, 98 7ª Edificio Trade 08028 Barcelona ŠPANIJA
4-7 days with drinking water 
4-5 dni s pitno vodo
Hungary CENAVISA, S.A. Camí Pedra Estela S/N 
Madžarska CENAVISA, S.A. Camí Pedra Estela S/N
INN Strength Pharmaceutical form 
Jakost Farmacevt ska oblika
Slovenia Novartis Veterina d.o.o. 
Slovenija Novartis Veterina d.o.o.
Two residue studies were in turkeys. 
Dve študiji ostankov sta bili izvedeni pri puranih.
Hungary Industria Italiana Integratori TREI S.p.A. 
Madžarska Industria Italiana Integratori TREI S.p.A.
Notwithstanding the fact that no clinical field study was presented to confirm the results obtained under experimental conditions, the use of doxycycline for the treatment of respiratory infections associated with P. multocida appears justified considering the good susceptibility of this pathogen to doxycycline (MIC90 up to 2µg/ml). 
Čeprav za potrditev rezultatov, dobljenih v eksperimentalnih pogojih, ni bila predstavljena klinična terenska študija, izgleda, da je uporaba doksiciklina za zdravljenje okužb dihal, povezanih s P. multocida, utemeljena, če upoštevamo dobro občutljivost tega bolezenskega povzročitelja za doksiciklin (MIK 90 do 2 µg/ml).
Indications: For the prevention and treatment of several bacterial infections. 
indikacije: za preprečevanje in zdravljenje različnih bakterijskih okužb
Via Togliatti n.5 42016 Guastalla (Reggio Emilia) ITALY 
Via Togliatti n.5 42016 Guastalla (Reggio Emilia) ITALIJA
INDUSTRIA ITAILIANA INTEGRATORI TREI SpA Via Affarosa n.4 42010 Rio Saliceto (Reggio Emilia) ITALY 
INDUSTRIA ITAILIANA INTEGRATORI TREI SpA Via Affarosa n.4 42010 Rio Saliceto (Reggio Emilia) ITALIJA
United kingdom 
Združeno kraljestvo
Estonia 
ESTONIJA