natgillin/translations-raw huggingface dataset:
NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Idacio 40 mg injection adalimumab 
IME ZDRAVILA IN POT(I) UPORABE Idacio 40 mg injekcija adalimumab s.c.
Table 18: Proportion of patientsa achieving HiSCRb at weeks 24 and 36 after treatment reassignment from weekly adalimumab at week 12 
Preglednica 18: Delež bolnikova, ki so dosegli klinični odziv (HiSCR)b v 24. in 36. tednu po spremembi zdravljenja v 12. tednu po jemanju adalimumaba vsak teden Placebo (ukinitev zdravljenja) N = 73
Storage information 
Navodila za shranjevanje
HS Study I 
Študija HS I
Idacio contains sodium 
Zdravilo Idacio vsebuje natrij
It is recommended that the conduct and results of these tests are recorded in the patient reminder card. Prescribers are reminded of the risk of false negative tuberculin skin test results, especially in patients who are severely ill or immunocompromised. 
Zdravniki se morajo zavedati tveganja za lažno negativne izvide tuberkulinskega kožnega testa, zlasti pri hudo bolnih ali imunsko oslabelih bolnikih.
ACR 20 Week 52 62.6% 54.4% 72.8% Week 104 56.0% 49.3% 69.4% ACR 50 Week 52 45.9% 41.2% 61.6% < 0.001 < 0.001 0.317 Week 104 42.8% 36.9% 59.0% < 0.001 < 0.001 0.162 ACR 70 Week 52 27.2% 25.9% 45.5% < 0.001 < 0.001 0.656 Week 104 28.4% 28.1% 46.6% < 0.001 < 0.001 0.864 a. p-value is from the pairwise comparison of methotrexate monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test. b. p-value is from the pairwise comparison of adalimumab monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test c. p-value is from the pairwise comparison of adalimumab monotherapy and methotrexate monotherapy using the Mann-Whitney U test 
52. teden 27,2 % 25,9 % 45,5 % < 0,001 < 0,001 0,656 104. teden 28,4 % 28,1 % 46,6 % < 0,001 < 0,001 0,864 a. Vrednost p se nanaša na parno primerjavo monoterapije z metotreksatom in kombinirane terapije z adalimumabom/metotreksatom z Mann-Whitneyevim testom U. b. Vrednost p se nanaša na parno primerjavo monoterapije z adalimumabom in kombinirane terapije z adalimumabom/metotreksatom z Mann-Whitneyevim testom U. c. Vrednost p se nanaša na parno primerjavo monoterapije z adalimumabom in monoterapije z metotreksatom z Mann-Whitneyevim testom U.
Following the administration of 24 mg/m2 (up to a maximum of 40 mg) subcutaneously every other week to patients with enthesitis-related arthritis who were 6 to 17 years, the mean trough steady-state (values measured at week 24) serum adalimumab concentrations were 8.8 ± 6.6 μg/mL for adalimumab without concomitant methotrexate and 11.8 ± 4.3 μg/mL with concomitant methotrexate. 
Po dajanju 24 mg/m2 (do največ 40 mg) subkutano vsak drugi teden bolnikom z artritisom, povezanim z entezitisom, ki so bili stari od 6 do 17 let, je bila povprečna najmanjša koncentracija adalimumaba v serumu v stanju dinamičnega ravnovesja (vrednost merjena v 24. tednu) 8,8 ± 6,6 μg/ml med uporabo adalimumaba brez metotreksata in 11,8 ± 4,3 μg/ml med sočasno uporabo metotreksata.
• The name on the pre-filled pen says Idacio (Figure I). 
• je na injekcijskem peresniku ime Idacio (Slika I).
Do not use this medicine after the expiry date which is stated on the label /carton after EXP. 
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki/škatli poleg oznake “EXP”.
Table 22: Proportion of patientsa achieving HiSCRb at weeks 24 and 36 after treatment reassignment from weekly adalimumab at week 12 
Preglednica 22: Delež bolnikova, ki so dosegli klinični odziv (HiSCR)b v 24. in 36. tednu po spremembi zdravljenja na jemanje adalimumaba vsak teden v 12. tednu Placebo (ukinitev zdravljenja) N = 73
Adalimumab was assessed in a multicenter, randomised, double-blind clinical trial designed to evaluate the efficacy and safety of induction and maintenance treatment with doses dependent on body weight (< 40 kg or ≥ 40 kg) in 192 paediatric subjects between the ages of 6 and 17 (inclusive) years, with moderate to severe Crohn´s disease (CD) defined as Paediatric Crohn's Disease Activity Index (PCDAI) score > 30. 
Adalimumab je bil ocenjen v multicentrični, randomizirani, dvojno slepi klinični študiji, ki je bila zasnovana za oceno učinkovitosti in varnosti uvodnega in vzdrževalnega zdravljenja z odmerki, odvisnimi od telesne mase (< 40 mg ali ≥ 40 mg) pri 192 pediatričnih bolnikih med 6. in 17.
Idacio is indicated for treatment of moderately to severely active Crohn's disease, in adult patients who have not responded despite a full and adequate course of therapy with a corticosteroid and/or an immunosuppressant; or who are intolerant to or have medical contraindications for such therapies. 
Zdravilo Idacio je indicirano za zdravljenje zmerno do hudo aktivne Crohnove bolezni pri odraslih bolnikih, ki se ne odzovejo na popoln in ustrezen ciklus zdravljenja s kortikosteroidom in/ali imunosupresivom, ali pa takšnega zdravljenja ne prenesejo oz. imajo zanj medicinske kontraindikacije.
When needed (for example when you are travelling), Idacio may be stored at room temperature (up to 25°C) for a maximum period of 14 days - be sure to protect it from light. 
Če je potrebno (na primer kadar potujete), lahko zdravilo Idacio hranite pri sobni temperaturi (do 25 °C) za največ 14 dni - zagotovite, da bo zaščiteno pred svetlobo.
Following the administration of 0.8 mg/kg (up to a maximum of 40 mg) subcutaneously every other week to paediatric patients with chronic plaque psoriasis, the mean ± SD steady-state adalimumab trough concentration was approximately 7.4 ± 5.8 µg/mL (79% CV). 
Po dajanju adalimumaba 0,8 mg/kg (do največ 40 mg) subkutano vsak drugi teden pediatričnim bolnikom s kronično psoriazo v plakih, so bile povprečne koncentracije adalimumaba v stanju dinamičnega ravnovesja približno 7,4 ± 5,8 µg/ml (79 % KV).
Adalimumab 40 mg every other week N = 70 
Adalimumab 40 mg vsak drugi teden N = 70
Each box of Idacio pre-filled syringe comes with two or six syringes. 
V vsaki škatli zdravila Idacio napolnjene injekcijske brizge sta dve ali šest injekcijskih brizg.
It is important that you tell your doctor if your child has symptoms of infections, e.g. fever, wounds, feeling tired, dental problems (see “Warnings and precautions”). 
Pomembno je, da zdravniku poveste, če ima vaš otrok simptome okužb, npr. zvišano telesno temperaturo, rane, občutek utrujenosti ali težave z zobmi (glejte "Opozorila in previdnostni ukrepi").
For patients who develop the signs and symptoms such as fever, malaise, weight loss, sweats, cough, dyspnoea, and/or pulmonary infiltrates or other serious systemic illness with or without concomitant shock an invasive fungal infection should be suspected and administration of Idacio should be promptly discontinued. 
Če se bolniku pojavijo znaki ali simptomi, kot so npr. zvišana telesna temperatura, splošno slabo počutje, hujšanje, znojenje, kašelj, dispneja in/ali pljučni infiltrati ali druga resna sistemska bolezen (s spremljajočim šokom ali brez njega), je treba posumiti na invazivno glivično okužbo.
Contents of the pack and other information What Idacio contains 
VSEBINA PAKIRANJA IN DODATNE INFORMACIJE Kaj vsebuje zdravilo Idacio - Učinkovina je adalimumab.
• Do not use an Idacio pre-filled pen that has been frozen or left in direct sunlight. 
• Zdravila Idacio napolnjen injekcijski peresnik ne uporabljajte, če je bil injekcijski peresnik zamrznjen ali dlje časa izpostavljen neposredni sončni svetlobi.
Idacio is used to treat severe plaque psoriasis in children and adolescents aged 4 to 17 years for whom medicines applied to the skin and treatment with UV light have either not worked very well or are not suitable. 
Zdravilo Idacio se uporablja za zdravljenje hude luskavice v plakih pri otrocih in mladostnikih, starih od 4 do 17 let, pri katerih zdravila, ki se nanašajo na kožo in zdravljenje z UV svetlobo nista dovolj dobro delovala ali pa nista primerna.
506 (62.2)b a Percent of patients achieving PASI75 response was calculated as centeradjusted rate b p<0.001, adalimumab vs. placebo 
506 (62,2)b Odstotek bolnikov, ki so dosegli odziv PASI 75, je bil izračunan kot delež, korigiran za center.
The recommended Idacio dose for patients with plaque psoriasis from 4 to 17 years of age is based on body weight (Table 3). 
Priporočeni odmerek zdravila Idacio pri bolnikih s psoriazo v plakih, starih od 4 do 17 let, temelji na telesni masi (preglednica 3).
NAME OF THE MEDICINAL PRODUCT Idacio 40 mg/0.8 mL solution for injection for paediatric use 
IME ZDRAVILA Idacio 40 mg/0,8 ml raztopina za injiciranje za pediatrično uporabo
Glucocorticoids, salicylates, nonsteroidal anti-inflammatory drugs, or analgesics can be continued during treatment with Idacio. 
Med zdravljenjem z zdravilom Idacio je mogoče nadaljevati z uporabo glukokortikoidov, salicilatov, nesteroidnih protivnetnih zdravil ali analgetikov.
You are advised to avoid becoming pregnant and must use adequate contraception while using Idacio and for at least 5 months after the last Idacio injection. 
Svetujemo vam, da preprečite nosečnost in uporabljate ustrezno kontracepcijsko zaščito, dokler uporabljate zdravilo Idacio in še 5 mesecev po zadnjem injiciranju zdravila Idacio.
Idacio dose for paediatric patients with plaque psoriasis 
Odmerjanje zdravila Idacio pri pediatričnih bolnikih s psoriazo v plakih
Idacio is used to treat psoriatic arthritis in adults. 
Zdravilo Idacio se uporablja za zdravljenje psoriatičnega artritisa pri odraslih.
≥30% Reduction in skin painb N = 109 
suppurativa (HiSCR)a ≥ 30 % zmanjšanje bolečine N = 109
Idacio is available as a vial, a pre-filled syringe and as a pre-filled pen. 
Zdravilo Idacio je lahko na voljo kot viala, napolnjena injekcijska brizga in napolnjen injekcijski peresnik.
PGA: Clear/minimalc a MTX = methotrexate b P=0.027, adalimumab 0.8 mg/kg versus MTX c P=0.083, adalimumaa 0.8 mg/kg versus MTX 
P = 0,027, adalimumab 0,8 mg/kg v primerjavi z MTX c P = 0,083, adalimumab 0,8 mg/kg v primerjavi z MTX
A 40 mg pre-filled syringe and a 40 mg pre-filled pen are also available for use. 
Za uporabo sta na voljo tudi 40 mg napolnjena injekcijska brizga in 40 mg napolnjen injekcijski peresnik.
The recommended Idacio dose is 80 mg at week 0 followed by 40 mg every other week starting at week 1 via subcutaneous injection. 
Priporočeni odmerek zdravila Idacio je 80 mg v 0. tednu, ki mu sledi 40 mg vsak drugi teden z začetkom v 1. tednu, v obliki subkutane injekcije.
Erosion score 
Disease Activity Score)
NAME OF THE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION Idacio 40 mg/0.8 mL injection adalimumab 
IME ZDRAVILA IN POT(I) UPORABE Idacio 40 mg/0,8 ml injekcija adalimumab s.c.
Adalimumab 40 mg weekly N = 70 
Adalimumab 40 mg vsak teden N = 70
Idacio is administered via subcutaneous injection. 
Zdravilo Idacio se uporablja kot subkutana injekcija.
Patients should be instructed to seek medical advice if signs/symptoms suggestive of a tuberculosis infection (e.g. persistent cough, wasting/weight loss, low grade fever, listlessness) occur during or after therapy with Idacio. 
Bolnikom je treba naročiti, naj poiščejo zdravniško pomoč, če med zdravljenjem z zdravilom Idacio ali po njem doživijo znake/simptome, ki nakazujejo tuberkulozno okužbo (npr. trdovraten kašelj, hujšanje/izgubljanje teže, nekoliko zvišano telesno temperaturo, ravnodušnost).
5.2 Clean the injection site with an alcohol pad and throw the pad away. 
5.2 Kožo na mestu injiciranja obrišite z zložencem, prepojenim z alkoholom, in ga zavrzite.
The recommended dose of Idacio for patients with polyarticular juvenile idiopathic arthritis from 2 years of age is based on body weight (Table 1). 
Priporočeni odmerek zdravila Idacio pri bolnikih s poliartikularnim juvenilnim idiopatskim artritisom, starih 2 leti in več, temelji na telesni masi (preglednica 1).
Idacio is used to treat ulcerative colitis in adults. 
Zdravilo Idacio se uporablja za zdravljenje ulceroznega kolitisa pri odraslih.
• Keep all components of the Idacio Vial Kit and the sharps disposal container out of reach and sight of children. 
• Pripomočke zdravila Idacio komplet z vialo in zbiralnik za ostre predmete shranjujte nedosegljivo otrokom.
Idacio 40 mg/0.8 mL solution for injection for paediatric use adalimumab 
Idacio 40 mg/0,8 ml raztopina za injiciranje za pediatrično uporabo adalimumab
What Idacio contains 
Kaj vsebuje zdravilo Idacio
The combination of adalimumab as well as other TNF-antagonists and anakinra or abatacept is not recommended based upon the possible increased risk for infections, including serious infections and other potential pharmacological interactions. 
Kombinacija adalimumaba in tudi drugih TNF antagonistov in anakinre ali abatacepta ni priporočljiva, saj temelji na možnosti, da poveča tveganje za okužbo, vključno z resnimi okužbami in ostalimi potencialnimi farmakološkimi interakcijami.
JSN score 2.0 (1.2-2.8) 1.3 (0.5-2.1) a p-value is from the pairwise comparison of methotrexate monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test. b p-value is from the pairwise comparison of adalimumab monotherapy and adalimumab/methotrexate combination therapy using the Mann-Whitney U test c p-value is from the pairwise comparison of adalimumab monotherapy and methotrexate monotherapy using the Mann-Whitney U test 
a Vrednost p se nanaša na parno primerjavo monoterapije z metotreksatom in kombinirane terapije z adalimumabom/metotreksatom z Mann-Whitneyevim testom U. b Vrednost p se nanaša na parno primerjavo monoterapije z adalimumabom in kombinirane terapije z adalimumabom/metotreksatom z Mann-Whitneyevim testom U. c Vrednost p se nanaša na parno primerjavo monoterapije z adalimumabom in monoterapije z metotreksatom z Mann-Whitneyevim testom U.
• If needed, for example when traveling, the Idacio Vial Kit can be stored at room temperature for up to 14 days. 
• Po potrebi lahko zdravilo Idacio komplet z vialo shranjujete pri sobni temperaturi do 14 dni, če na primer potujete.
When needed (for example when you are travelling), a single Idacio pre-filled syringe may be stored at room temperature (up to 25°C) for a maximum period of 14 days - be sure to protect it from light. 
Če je potrebno (na primer kadar potujete), lahko posamezno napolnjeno injekcijsko brizgo Idacio hranite pri sobni temperaturi (do 25 ºC) za največ 14 dni - zagotovite, da bo zaščitena pred svetlobo.
Your healthcare provider should show you how to prepare and inject Idacio properly using the pre-filled syringe before you use it for the first time. 
Vaš zdravstveni delavec vam mora pokazati kako pravilno pripraviti in injicirati zdravilo Idacio preden boste napolnjeno injekcijsko brizgo prvič uporabili.
Table 18 Ps Study II (CHAMPION) efficacy results at 16 weeks Placebo N=53 n (%) 
b p < 0,001, adalimumab v primerjavi s placebom Preglednica 18: Študija pri psoriazi II (CHAMPION) Rezultati učinkovitosti po 16 tednih placebo n = 53 n (%)
If these medicines do not work well enough, your child will be given Idacio to treat his/her polyarticular juvenile idiopathic arthritis or enthesitis-related arthritis. 
Če ta zdravila ne delujejo dovolj dobro, bo vaš otrok za zdravljenje poliartikularnega juvenilnega idiopatskega artritisa ali artritisa, povezanega z entezitisom dobil zdravilo Idacio.
4.5 Place the syringe on a clean, flat surface. 
4.5 Injekcijsko brizgo položite na čisto, ravno površino.
Idacio is used to treat moderate to severe plaque psoriasis in adults. 
Zdravilo Idacio se uporablja za zdravljenje zmerne do hude luskavice (psoriaze) v plakih pri odraslih.
• Store the Idacio Vial Kit in a refrigerator between 2°C to 8°C. 
• Zdravilo Idacio komplet z vialo shranjujte v hladilniku pri temperaturi med 2 °C in 8 °C.
• Store the Idacio Vial Kit in its original box to protect it from light. 
• Zdravilo Idacio komplet z vialo shranjujte v originalni ovojnini za zagotovitev zaščite pred svetlobo.
Your child is advised to avoid becoming pregnant and must use adequate contraception while using Idacio and for at least 5 months after the last Idacio injection. 
Za vašega otroka je priporočljivo, da ne zanosi in uporablja ustrezno kontracepcijsko zaščito, dokler uporablja zdravilo Idacio in še 5 mesecev po zadnjem injiciranju zdravila Idacio.
Adalimumab has been studied in rheumatoid arthritis, polyarticular juvenile idiopathic arthritis and psoriatic arthritis patients taking adalimumab as monotherapy and those taking concomitant methotrexate. 
4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Adalimumab so raziskali pri bolnikih z revmatoidnim artritisom, poliartikularnim juvenilnim idiopatskim artritisom in psoriatičnim artritisom, ki so adalimumab jemali kot monoterapijo, kot pri tistih, ki so ga jemali hkrati z metotreksatom.
If you become pregnant, you should see your doctor. 
Če zanosite, je potrebno obiskati zdravnika.
In adult patients with hidradenitis suppurativa, a dose of 160 mg adalimumab on week 0 followed by 80 mg on week 2 achieved serum adalimumab trough concentrations of approximately 7 to 8 μg/mL at week 2 and week 4. 
Pri odraslih bolnikih s hidradenitis suppurativa doseže odmerek 160 mg adalimumaba na 0. teden, ki mu sledi 80 mg adalimumaba 2. teden, najnižjo koncentracijo adalimumaba v serumu pred naslednjim odmerkom približno 7 do 8 µg/ml v 2. tednu in v 4. tednu.
QUALITATIVE AND QUANTITATIVE COMPOSITION Idacio 40 mg solution for injection in pre-filled syringe Each 0.8 ml single dose pre-filled syringe contains 40 mg of adalimumab. 
KAKOVOSTNA IN KOLIČINSKA SESTAVA Idacio 40 mg raztopina za injiciranje v napolnjeni injekcijski brizgi Ena 0,8 ml enoodmerna napolnjena injekcijska brizga vsebuje 40 mg adalimumaba.
Table 24 Maintenance of clinical remission and response (percent of patients) Placebo 
Preglednica 24: Vzdrževanje klinične remisije in odziva (odstotek bolnikov)
Table 23 Maintenance of clinical remission and response (percent of patients) Placebo 
Preglednica 23 Vzdrževanje klinične remisije in odziv (Odstotek bolnikov)
The recommended Idacio induction dose regimen for adult patients with moderate to severe ulcerative colitis is 160 mg at week 0 (given as four 40 mg injections in one day or as two 40 mg injections per day for two consecutive days) and 80 mg at week 2 (given as two 40 mg injections in one day). 
Priporočena shema odmerjanja zdravila Idacio med indukcijo je pri odraslih bolnikih z zmerno do hudo aktivnim ulceroznim kolitisom 160 mg 0. teden (aplicirano kot štiri 40 mg injekcije v enem dnevu ali kot dve 40 mg injekciji na dan dva dni zapored) in 80 mg 2. teden (aplicirano kot dve 40 mg injekciji v enem dnevu).
Your healthcare provider should show you how to prepare and inject Idacio properly using the vial kit before you use it for the first time. 
Vaš zdravstveni delavec vam mora pokazati kako pravilno pripraviti in injicirati zdravilo Idacio preden boste komplet z vialo prvič uporabili.
A loading dose of 160 mg adalimumab on week 0 followed by 80 mg adalimumab on week 2 achieves serum adalimumab trough concentrations of approximately 12 µg/mL during the induction period. 
Polnilni odmerek 160 mg adalimumaba na 0. teden, ki mu sledi 80 mg adalimumaba 2. teden, doseže med obdobjem indukcije najmanjšo koncentracijo v serumu približno 12 µg/ml.
The recommended Idacio dose regimen for adult patients with hidradenitis suppurativa (HS) is 160 mg initially at day 1 (given as four 40 mg injections in one day or as two 40 mg injections per day for two consecutive days), followed by 80 mg two weeks later at day 15 (given as two 40 mg injections in one day). 
Priporočena shema odmerjanja zdravila Idacio pri odraslih bolnikih s hidradenitis suppurativa (HS) je 160 mg na 1. dan (aplicirano v obliki štirih 40 mg injiciranj na dan ali z dvema 40 mg injiciranjema na dan, dva dni zapored), ki mu sledi 80 mg dva tedna kasneje na 15. dan (aplicirano v obliki dveh 40 mg injiciranj v enem dnevu).
• Hold the syringe upward and pull the needle cap straight off (Figure N). 
Injekcijsko brizgo držite obrnjeno navzgor in odstranite pokrovček na injekcijski igli (Slika N).
In adult patients with uveitis, a loading dose of 80 mg adalimumab on week 0 followed by 40 mg adalimumab every other week starting at week 1, resulted in mean steady-state concentrations of approximately 8 to 10 µg/mL. 
Pri odraslih bolnikih z uveitisom je polnilni odmerek 80 mg adalimumaba v 0. tednu, ki mu je sledil odmerek 40 mg adalimumaba vsak drugi teden z začetkom v 1. tednu, povzročil srednjo koncentracijo v stanju dinamičnega ravnovesja približno 8 do 10 µg/ml.
Your healthcare provider should show you how to prepare and inject Idacio properly using the pre-filled pen before you use it for the first time. 
Vaš zdravstveni delavec vam pokazati, kako pravilno pripraviti in injicirati zdravilo Idacio preden boste napolnjen injekcijsko peresnik prvič uporabili.
Adalimumab treated patients showed statistically significant improvements at week 26 compared with placebo in the DLQI. 
Pri bolnikih, zdravljenih z adalimumabom, je prišlo do statistično značilnega izboljšanja dermatološkega indeksa kakovosti življenja (DLQI) po 26 tednih v primerjavi s placebom.
Available data suggest that clinical response is usually achieved within 12 weeks of treatment. 
Podatki, ki so na voljo, kažejo, da je klinični odziv po navadi dosežen v 12 tednih zdravljenja.
Solution for injection 2 pre-filled syringes 2 alcohol pads 6 pre-filled syringes 6 alcohol pads 
raztopina za injiciranje 2 napolnjeni injekcijski brizgi 2 alkoholna zloženca 6 napolnjenih injekcijskih brizg 6 alkoholnih zložencev
There is no relevant use of Idacio in children aged less than 2 years in this indication. 
Uporaba zdravila Idacio pri otrocih, mlajših od 2 let, za to indikacijo ni primerna.
• Lift the pre-filled pen from your skin (Figure Q). 
• Injekcijski peresnik odmaknite od kože (Slika Q).
Following the administration of 24 mg/m2 (up to a maximum of 40 mg) subcutaneously every other week to patients with polyarticular juvenile idiopathic arthritis (JIA) who were 4 to 17 years the mean trough steady-state (values measured from week 20 to 48) serum adalimumab concentration was 5.6 ± 5.6 µg/mL (102% CV) for adalimumab without concomitant methotrexate and 10.9 ± 5.2 µg/mL (47.7% CV) with concomitant methotrexate. 
Po uporabi 24 mg/m2 (do največ 40 mg) subkutano vsak drugi teden pri bolnikih s poliartikularnim juvenilnim idiopatskim artritisom (pJIA), ki so bili stari od 4 do 17 let, je bila povprečna najmanjša koncentracija adalimumaba v serumu v stanju dinamičnega ravnovesja (vrednosti merjene od 20. do 48.tedna) med uporabo adalimumaba brez metotreksata 5,6 ± 5,6 µg/ml (koeficient variacije 102 %) in med uporabo z metotreksatom 10,9 ± 5,2 µg/ml (koeficient variacije 47,7 %).
Idacio should be used with caution in patients with mild heart failure (NYHA class I/II). 
Pri bolnikih z blagim srčnim popuščanjem (razred I/II po NYHA) je treba zdravilo Idacio uporabljati previdno.
Idacio dose for paediatric patients with uveitis 
Odmerjanje zdravila Idacio pri pediatričnih bolnikih z uveitisom
In patients who have been exposed to tuberculosis and patients who have travelled in areas of high risk of tuberculosis or endemic mycoses, such as histoplasmosis, coccidioidomycosis, or blastomycosis, the risk and benefits of treatment with Idacio should be considered prior to initiating therapy (see Other opportunistic infections). 
Pred začetkom zdravljenja je treba tveganja in koristi zdravljenja z zdravilom Idacio pretehtati pri bolnikih, ki so bili izpostavljeni tuberkulozi, in bolnikih, ki so potovali na območja, kjer obstaja veliko tveganje tuberkuloze ali endemičnih mikoz, npr. histoplazmoze, kokcidioidomikoze ali blastomikoze (glejte Druge oportunistične okužbe).
5.1 Wipe the skin of your injection site with an alcohol pad to clean it (Figure K). 
5.1 Kožo na mestu injiciranja obrišite z zložencem, prepojenim z alkoholom, da jo očistite.