natgillin/translations-raw huggingface dataset:
Subsequent injections of Ceplene may be self-administered at home by a patient who demonstrates a good understanding of necessary precautions and who has demonstrated adequate injection skills. 
Nadaljnje injiciranje zdravila Ceplene lahko izvaja bolnik sam doma, če ustrezno razume potrebne previdnostne ukrepe in izkazuje zadovoljivo spretnost ravnanja z injekcijo.
Always inject IL-2 first. 
Vedno najprej injicirajte IL-2.
It is used together with low doses of interleukin-2 (IL-2), another medicine which helps the immune system to fight diseases like cancer. 
Uporablja se skupaj z majhnim odmerkom interlevkina-2 (IL-2), zdravila, ki prav tako pomaga imunskemu sistemu v boju proti bolezni, kot je rak.
Hypotension (low blood pressure) may occur very commonly and may lead to light-headedness and fainting. 
Hipotenzija (nizek krvni tlak) se lahko pojavi zelo pogosto in lahko povzroči omotičnost in omedlevico.
No carcinogenicity studies have been performed on Ceplene. 
Študij kancerogenosti z zdravilom Ceplene niso izvedli.
Plasma histamine concentrations were highly variable and were considerably higher in the groups of patients with moderate or severe hepatic impairment (medians 10 and 5 times the normal volunteers respectively). 
Plazemske koncentracije histamina so se zelo spreminjale in so bile bistveno višje pri skupinah bolnikov z zmernimi ali hudimi jetrnimi okvarami (mediani sta bili 10- oziroma 5-krat višji kot pri zdravih prostovoljcih).
Ceplene and low dose IL-2 have been investigated in other clinical studies at different doses (1 mg histamine dihydrochloride twice a day) and with different dose regimens of low-dose IL-2 and interferon-alfa. 
Zdravilo Ceplene in majhne odmerke IL-2 so preučevali tudi v drugih kliničnih študijah z različnimi odmerki (1 mg histaminijevega diklorida dvakrat na dan) in z drugimi režimi odmerjanja z majhnimi odmerki IL-2 in interferonom alfa.
• Constipation, swollen stomach, inflamed mouth 
• zaprtost, otečen trebuh, vneta usta
It has been noted that neuromuscular blocking agents, narcotic analgesics, and various contrast media can induce the release of endogenous histamine; therefore in patients undergoing diagnostic or surgical procedures, the additive effect of Ceplene treatment should be considered prior to the procedure (see section 4.4). 
Opaženo je bilo, da lahko zaviralci živčno-mišičnega prenosa, narkotični analgetiki in različna kontrastna sredstva inducirajo sproščanje endogenega histamina, zato je pri bolnikih, napotenih na diagnostične ali kirurške postopke, treba upoštevati dodatni učinek zdravljenja z zdravilom Ceplene pred postopkom (glejte poglavje 4.4).
The solution must be clear and colourless. 
Raztopina mora biti bistra in brezbarvna.
IL-2 16 400 IU/kg followed by 0.5 mL Ceplene. 
IL-2 16.400 i.e/kg, čemur sledi 0,5 mL zdravila Ceplene.
• Drying-out of the body (dehydration) 
• izguba vode iz telesa (dehidracija)
Treatment cycles 
Cikli zdravljenja
To prepare a dose of Ceplene you will need the following: 1 vial of Ceplene solution (0.5 mL) 1 sterile graduated syringe with needle 1 alcohol wipe 
Za pripravo odmerka zdravila Ceplene boste potrebovali: 1 vialo raztopine zdravila Ceplene (0,5 mL) 1 sterilno kalibrirano brizgo z iglo 1 alkoholno krpico
If you are not sure about how to give yourself the injection or you have any questions, please ask your doctor or nurse for help. 
Če niste prepričani o tem, kako si samoinjicirati zdravilo, ali imate kakršna koli vprašanja, se po pomoč obrnite na zdravnika ali medicinsko sestro.
The needle must be inserted under the skin, but not into any blood vessels below the skin. 
Igla mora biti pod kožo, vendar ne v žili v podkožju.
Patient monitoring during subsequent treatment days or cycles should be performed as long as the patient continues to experience significant changes in vital signs during administration of Ceplene. 
Spremljanje bolnikov med nadaljnjim zdravljenjem v ciklu ali med naslednjimi cikli naj poteka, dokler se pri bolniku pojavljajo bistvene spremembe v življenjskih znakih med uporabo zdravila Ceplene.
Recommended dose 
Priporočeni odmerek
Animal studies showed reproductive toxicity but only at maternotoxic doses, and did not indicate direct harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3). 
Študije na živalih so pokazale reproduktivno toksičnost, vendar le pri uporabi odmerkov, toksičnih za mater, in ne nakazujejo neposrednih škodljivih vplivov na nosečnost, razvoj zarodka/ploda, porod ali postnatalni razvoj (glejte poglavje 5.3).
Other medicines and Ceplene 
Druga zdravila in zdravilo Ceplene
Patients with renal impairment may be more sensitive to the blood pressure lowering effects of Ceplene. 
Bolniki z ledvično okvaro so lahko bolj občutljivi na zniževanje krvnega tlaka, ki ga povzroči zdravilo Ceplene.
• The other ingredients are water for injections and sodium chloride, and it may also contain sodium hydroxide and/or hydrochloric acid for pH adjustment. 
• Druge sestavine zdravila so voda za injekcije in natrijev klorid, zdravilo pa lahko vsebuje tudi natrijev hidroksid in/ali klorovodikovo kislino za uravnavanje pH.
Histamine is eliminated by metabolism in kidney, liver and other tissues. 
Histamin se iz organizma izloča s presnavljanjem v ledvicah, jetrih in drugih tkivih.
• Sensation of spinning (vertigo) 
• občutek vrtoglavice (vertigo)
Certain medicines used for an operation (for example neuromuscular blocking medicines and narcotic pain-killers) or dyes used for certain Xrays may interfere with this medicine. 
Določena zdravila, ki se uporabljajo pri operacijah (na primer zdravila za zaviranje živčno-mišičnega prenosa in narkotična protibolečinska zdravila) ali določena barvila za uporabo pri rentgenskem slikanju, lahko vplivajo na delovanje tega zdravila.
1 Take 1 vial out of the carton. 
Iz škatle vzemite 1 vialo.
The role of Ceplene is to protect lymphocytes, in particular NK cells and T cells, which are responsible for the immune-mediated destruction of residual leukaemic cells. 
Vloga zdravila Ceplene je zaščititi limfocite, zlasti celice ubijalke (NK celice) in T celice, ki so odgovorne za imunsko uničevanje preostalih levkemičnih celic.
Slightly pull back the plunger. 
Bat potegnite rahlo nazaj.
Double check the vial label to make sure you are using the correct medicine. 
Ponovno preverite nalepko na viali in se prepričajte, ali uporabljate pravo zdravilo.
H2 receptor antagonists with imidazole structures similar to histamine, e.g., cimetidine, systemic steroids and clonidine, must not be used during treatment with Ceplene (see section 4.3). 
Antagonistov receptorjev H2 z imidazolnimi strukturami, podobnimi histaminu, na primer cimetidina, sistemskih steroidov in klonidina, med zdravljenjem z zdravilom Ceplene ne smemo uporabljati (glejte poglavje 4.3).
Ceplene must be injected slowly in the layer of tissue just under the skin (subcutaneously), over a period of approximately 5 to 15 minutes. 
Zdravilo Ceplene je treba injicirati počasi, v plast tkiva neposredno pod kožo (subkutano), v času trajanja od približno 5 do 15 minut.
Rapid injection can cause a drop in your blood pressure and make you feel faint or even pass out. 
Hitro injiciranje lahko povzroči padec krvnega tlaka, zaradi česar lahko občutite omotico ali se celo onesvestite.
Each 0.5 mL Ceplene dose is injected slowly, over 5-15 minutes. 
Vsak 0,5 mL odmerek zdravila Ceplene se injicira počasi, in sicer v 5-15 minutah.
• Accumulation of fluid in the body especially in the legs (oedema) 
• zadrževanje tekočine v telesu, zlasti v nogah (edem)
What Ceplene is and what it is used for What you need to know before you use Ceplene How to use Ceplene 
Kaj je zdravilo Ceplene in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Ceplene Kako uporabljati zdravilo Ceplene Možni neželeni učinki
Patients showed a higher degree of variability with respect to systemic exposure as compared to healthy subjects. 
Pri bolnikih se je pokazala večja stopnja variabilnosti zaradi sistemske izpostavljenosti v primerjavi z zdravimi prostovoljci.
Where appropriate, consideration should be made to providing concomitant treatment with a proton pump inhibitor. 
Kadar je potrebno, lahko razmislite o sočasnem zdravljenju z zaviralci protonske črpalke.
Ceplene is available in pack sizes of 14 vials. 
Zdravilo Ceplene je na voljo v škatlah s 14 vialami.
You will start your treatment with Ceplene in the clinic under supervision of a doctor. 
Zdravljenje z zdravilom Ceplene boste pričeli v bolnišnici pod nadzorom zdravnika.
Your doctor may want to increase the time you take to complete your injection, or change your dose. 
Morda bo zdravnik podaljšal čas injiciranja ali spremenil odmerek zdravila.
• Feeling your own heart beat (palpitations) 
• občutenje lastnega srčnega utripa (palpitacije)
Patients with a prior history of autoimmune disease (including systemic lupus, inflammatory bowel disease, psoriasis and rheumatoid arthritis) should be treated with caution. 
Bolnike z avtoimunimi boleznimi v anamnezi (vključno s sistemskim lupusom, vnetno črevesno boleznijo, psoriazo in revmatoidnim artritisom) je treba zdraviti previdno.
There have been 2 clinical studies to evaluate the use of Ceplene in the maintenance of remission in adult AML patients. 
Izvedeni sta bili dve klinični študiji za ovrednotenje uporabe zdravila Ceplene pri vzdrževanju remisije pri odraslih bolnikih z akutno mieloično levkemijo.
• H2 blockers such as cimetidine, ranitidine, famotidine or nizatidine. 
• Antagonisti H2, kot so cimetidin, ranitidin, famotidin ali nizatidin.
INSTRUCTIONS FOR INJECTION 
NAVODILA ZA INJICIRANJE
If significant hypotension or related symptoms are observed in subsequent treatment cycles, dose reduction should be initiated and if required, administered in hospital until responses to treatment allow for home administration. 
Če se pri bolniku med zdravljenjem v naslednjih ciklih očitno pojavi hipotenzija ali povezani simptomi, je treba ustrezno zmanjšati odmerek zdravila in po potrebi zdravilo injicirati v bolnišnici, dokler odziv na zdravljenje ne omogoči uporabe zdravila doma.
The randomised phase 3 trial (0201) compared Ceplene+IL-2 treatment to no treatment in 261 patients in first remission (CR1) and in another 59 patients in subsequent remission after relapse (CR>1). 
V randomiziranem preskušanju faze 3 (0201) so primerjali sočasno zdravljenje z zdravilom Ceplene in IL-2 s stanjem brez zdravljenja pri 261 bolnikih v prvi remisiji (CR1), v drugem preskušanju pa 59 bolnikov v ponovni remisiji po relapsu (CR>1).
Your doctor may advise you that it is appropriate to use a syringe pump to regulate the injection of Ceplene. 
Zdravnik vam lahko priporoča uporabo črpalke za brizgo za uravnavanje injiciranja zdravila Ceplene.
Decide where you will inject Ceplene. 
Izberite mesto, kamor boste injicirali zdravilo Ceplene.
The mechanism by which Ceplene improves the anti-leukaemic function of lymphocytes in AML is not completely established; it is considered to be by inhibition of reactive oxygen species (ROS or ‘oxygen free radicals'), which are synthesised by monocytes/macrophages and granulocytes. 
Mehanizem, s katerim zdravilo Ceplene izboljšuje protilevkemično delovanje limfocitov pri akutni mieloični levkemiji, še ni v celoti dognan, vendar naj bi zaviral reaktivne kisikove vrste (ROSreactive oxygen species ali kisikovi prosti radikali), ki jih sintetizirajo monociti/makrofagi in granulociti.
The active substance in Ceplene is histamine dihydrochloride; it is identical to a naturally occurring substance in the body. 
Učinkovina v zdravilu Ceplene je histaminijev diklorid, ki je popolnoma enak kot snov, ki je naravno prisotna v človeškem telesu.
Ceplene is used in adult patients, together with IL-2, to treat a particular type of leukaemia called acute myeloid leukaemia (AML) which is a cancer of blood forming cells in the bone marrow. 
Zdravilo Ceplene se uporablja pri odraslih bolnikih skupaj z IL-2 za zdravljenje specifične vrste levkemije, imenovane akutna mieloična levkemija (AML), ki je rak matičnih krvotvornih celic v kostnem mozgu.
Ceplene must not be mixed with any other products and must not be diluted. 
Zdravila Ceplene ne smete mešati z nobenim drugim zdravilom in ga ne razredčevati.
The European Medicines Agency will review any new information on this medicine every year and this package leaflet will be updated as necessary. 
Evropska agencija za zdravila bo vsako leto ponovno pregledala vse nove podatke o tem zdravilu.
If the patient experiences a significant change in vital signs, the physician should evaluate the status of the patient and continue to monitor vital signs; these patients should be monitored during subsequent treatments. 
Če se pri bolniku pojavijo bistvene spremembe v življenjskih znakih, mora zdravnik oceniti status bolnika in nadaljevati nadzor življenjskih znakov.
Push the plunger of the syringe down to inject air into the vial. 
Bat brizge potisnite navzdol, tako da boste zrak iztisnili v vialo.
• a history of auto-immune disease (a disease where the immune system attacks the body's own cells or tissues, such as systemic lupus, rheumatoid arthritis, inflammatory bowel disease or psoriasis). 
• avtoimunske bolezni v preteklosti (bolezen, pri kateri imunski sistem napada lastne telesne celice ali tkiva, kot je na primer sistemski lupus, revmatoidni artritis, vnetne črevesne bolezni ali psoriaza).
Dosing volumes based on patient weight are provided in Table 3 below. 
Odmerni volumni, glede na telesno maso bolnika, so navedeni v Preglednici 3 spodaj.
Interleukin-2 (IL-2) 
Interlevkin-2 (IL-2)
Use an alcohol wipe to clean the rubber part of the stopper. 
Z alkoholno krpico očistite gumijasti del zaporke.
The usual time for administering a 0.5 mL Ceplene dose is 5 minutes. 
Običajni čas za injiciranje 0,5 mL zdravila Ceplene je 5 minut.
This is to be returned to the pharmacist for disposal. 
To vrnite farmacevtu, ki bo zdravilo varno odstranil.
For further instructions on how to inject this medicine yourself, please read the section “INSTRUCTIONS FOR SELF-INJECTION OF CEPLENE” at the end of this leaflet. 
Nadaljnja navodila za samoinjiciranje zdravila preberite v poglavju „NAVODILA ZA SAMOINJICIRANJE ZDRAVILA CEPLENE“ na koncu teh navodil za uporabo.
Subcutaneous use only. 
Samo za subkutano uporabo.
Patients with all degrees of hepatic impairment may have tachycardia or hypotension for 30-60 minutes after Ceplene+IL-2 administration. 
Pri bolnikih z različnimi stopnjami jetrnih okvar se lahko za 30-60 minut po uporabi zdravila Ceplene+IL-2 pojavi tahikardija ali hipotenzija.
• Inflammation of the stomach (gastritis) 
• vnetje želodca (gastritis)
Ceplene should not be injected into the same anatomic region as IL-2. 
Zdravilo Ceplene ne sme biti injicirano na isto anatomsko mesto kot IL-2.
If not, use another vial and inform your doctor or pharmacist. 
Če ni, uporabite drugo vialo in o tem obvestite zdravnika ali farmacevta.
In the peri-post natal development study, high doses of histamine dihydrochloride caused maternal toxicity, and the offspring showed toxicity during lactation (fewer live pups at day 21 compared to lactation at day 4) but not after weaning. 
Razvojne med- in postnatalne študije so pokazale, da visoki odmerki histaminijevega diklorida povzročajo toksičnost pri materi ter da se pri potomcih v obdobju sesanja kažejo znaki toksičnosti (manj živih mladičev v 21. dnevu sesanja, v primerjavi s 4 dnevom), vendar ne več v obdobju, ko nehajo sesati.
• If you are receiving one of the following medicines: - Steroids such as prednisone and dexamethasone. 
• če jemljete katero od navedenih zdravil: - steroide, kot je prednizon in deksametazon.
Do not drive or use machines within one hour after receiving a Ceplene injection as it may reduce blood pressure causing dizziness, light-headedness and blurred vision. 
Ne vozite in ne upravljajte strojev v času ene ure po uporabi zdravila Ceplene, saj lahko to povzroči znižanje krvnega tlaka in omotičnost, lahko glavo ter zamegljen vid, kar lahko vpliva na vašo sposobnost upravljanja vozil in strojev.
Injections should be preferably administered in a supervised setting in the presence of an adult family member, friend, or other care provider who is capable of responding appropriately should signs or symptoms of hypotension occur. 
Injiciranje zdravila naj poteka v nadzorovanem okolju, v prisotnosti odraslega družinskega člana, prijatelja ali drugega skrbnika, sposobnega ustrezno reagirati v primeru pojava znakov ali simptomov hipotenzije pri bolniku.
Place the pre-prepared syringes containing IL-2, Ceplene and an opened alcohol wipe where you can reach them. 
Pripravljeni brizgi z IL-2 in zdravilom Ceplene ter odprto alkoholno krpico položite tako, da jih lahko dosežete.
Interleukin-2 (IL-2) is commercially available as a recombinant IL-2; aldesleukin. 
Interlevkin-2 (IL-2) je komercialno dostopen kot rekombinantni IL-2; aldeslevkin.
• Pain in limbs and back pain 
• bolečine v okončinah in v hrbtu
Use only clear and colourless solution. 
Uporabite samo bistro in brezbarvno raztopino.
Make sure that the area of the skin you select is exposed. 
Prepričajte se, da je izbrano mesto dovolj razkrito.
They are used to inhibit activity of the immune system (immunosuppressant) and to reduce inflammation (see above “Do not use Ceplene”). 
Ti se uporabljajo za zaviranje delovanja imunskega sistema (imunosupresiv) in za zmanjšanje vnetja (glejte poglavje zgoraj „Ne uporabljajte zdravila Ceplene“).
Caution should be used for patients with any of the following: symptomatic peripheral arterial disease, past or present peptic or oesophageal ulcer disease with a history of bleeding, clinically significant renal disease and stroke within the last 12 months. 
Posebna previdnost je potrebna pri bolnikih, pri katerih se pojavlja simptomatska periferna arterijska bolezen, ki so imeli ali imajo peptično razjedo ali razjede požiralnika s krvavitvami v anamnezi, klinično pomembne ledvične bolezni in kap v zadnjih 12 mesecih.
• Infections of the upper breathing (respiratory) tract 
• okužbe zgornjih dihalnih (respiratornih) poti
Patients with cardiac disease should be evaluated for ventricular ejection fraction and wall function by echocardiography or nuclear medicine stress test and then treated with caution. 
Pri bolnikih s srčnimi boleznimi je treba ustrezno oceniti iztisni delež levega prekata in delovanje srčne stene z elektrokardiografom ali stresnim testom nuklearne medicine, pri zdravljenju pa je potrebna previdnost.
Tricyclic anti-depressants may have H1 and H2 receptor blocking properties and should be avoided. 
Triciklični antidepresivi lahko imajo lastnosti antagonistov receptorjev H1 in H2 in se jim je zato treba izogibati.
Ceplene must be injected 1 to 3 minutes later. 
Zdravilo Ceplene se injicira 1 do 3 minute kasneje.
Women of childbearing potential and sexually active men must use effective methods of contraception during treatment with Ceplene and IL-2. 
Ženske v rodni dobi in spolno aktivni moški morajo med zdravljenjem z zdravilom Ceplene in IL-2 uporabljati učinkovito kontracepcijo.
Dispose of the syringe in the puncture-proof container as instructed. 
Brizgo odvrzite v poseben zabojnik v skladu z navodili.
It is not known whether Ceplene appears in breast milk. 
Ni znano, ali se zdravilo Ceplene pojavlja v mleku doječe matere.
They are used for angina and heart beat disorders. 
Uporabljajo se za zdravljenje angine pektoris in motenj srčnega utripa.
Administration of Ceplene or IL-2 by rapid infusion or into vascular spaces, at higher doses than the approved ones, may exaggerate the adverse reactions associated with Ceplene. 
Uporaba zdravila Ceplene ali IL-2 po hitrem injiciranju ali injiciranju v žilni prostor v višjih odmerkih kot so priporočeni, lahko stopnjuje neželene učinke, povezane z uporabo zdravila Ceplene.
For patients experiencing grade 3 and 4 (including hypotension, arrhythmia) toxicities - treatment should be discontinued until the event is resolved. 
Za bolnike, pri katerih se pojavlja 3. in 4. stopnja toksičnosti (vključno s hipotenzijo, aritmijo) - zdravljenje je treba prekiniti, dokler dogodki ne izzvenijo.
• Joint and muscle pain (arthralgia and myalgia) 
• bolečine v sklepih in mišicah (artralgija in mialgija)
• Headache and dizziness 
• glavobol in omotičnost
• Decrease in the number of red blood cells (anaemia) 
• upad števila rdečih krvnih celic (anemija)
It is unknown whether histamine is excreted in human breast milk. 
Ni znano ali se histamin med dojenjem izloča v materino mleko.
Ceplene can be administered via an ambulatory infusion syringe pump or by controlled manual subcutaneous injection by syringe with a timer. 
Zdravilo Ceplene se lahko daje z ambulantno infuzijo s črpalno injekcijo ali z nadzorovanim ročnim subkutanim injiciranjem z injekcijo z merilnikom časa.
For CR1 patients, the median duration of leukaemia-free survival increased from 291 days (9.7 months) to 450 days (15 months) after Ceplene/IL-2 versus no maintenance treatment (Intention to Treat [ITT], p=0.01. 
Pri CR1 bolnikih se je po zdravljenju s kombinacijo zdravila Ceplene in IL-2 mediana trajanja preživetja brez levkemije podaljšala z 291 dni (9,7 meseca) na 450 dni (15 mesecev) v primerjavi z bolniki, ki niso prejemali vzdrževalnega zdravljenja (Intention to treat - z namenom zdravljenja [ITT], p=0,01, n=261).
The excretion of histamine in milk has not been studied in animals, but at maternotoxic doses in rats, offspring showed slight toxicity during early lactation (see section 5.3). 
Izločanje histamina v mleko pri živalih ni bilo preučeno, pri podganah pa se je pri uporabi odmerkov, toksičnih za mater, pri potomcih pokazala rahla toksičnost med zgodnjo fazo dojenja (glejte poglavje 5.3).
For patients experiencing grade 1-4 generalised toxic dermatitis -for grade 1 toxicity, the treatment should be delayed for 48 hours or until all symptoms have been resolved. 
Za bolnike, pri katerih se pojavlja 1.-4. stopnja generaliziranega toksičnega dermatitisa - pri 1. stopnji toksičnosti je treba zdravljenje prekiniti za 48 ur ali dokler simptomi ne izginejo.
The number of CR1 patients remaining leukaemia-free for 3 years was 40% after Ceplene+IL-2 versus 26% in patients not receiving this treatment (p=0.01). 
Delež bolnikov iz skupine CR1, ki po zdravljenju z zdravilom Ceplene+IL-2 tri leta niso ponovno oboleli za levkemijo, je bil 40 % v primerjavi s 26 % bolnikov, ki niso prejemali tega zdravljenja (p=0,01).
• Any treatment for high blood pressure (for example thiazide diuretics [bendrofluazide], ACE inhibitors [captopril], calcium antagonists [nifedipine] and alpha-blockers [prazosin]). 
• Katero koli drugo zdravilo za povišan krvni tlak (na primer tiazidni diuretiki [bendrofluazid], zaviralci ACE [kaptopril], kalcijevi antagonisti [nifedipin] ali zaviralci alfa [prazosin].
Table 2: For treatment cycles 4-10 with Ceplene and IL-2, same as for Table 1 above, with the exception of number of cycles and duration of rest periods 
Preglednica 2: Za zdravljenje z zdravilom Ceplene in IL-2 v ciklih 4-10 velja enako, kot je navedeno v zgornji preglednici 1, z izjemo števila ciklov in trajanja obdobja brez zdravljenja.
Cycles w.19 
Cikli t. 19
Doses of Ceplene and IL-2 should be modified as necessary based on individual patient tolerance to treatment. 
Odmerke zdravila Ceplene in IL-2 po potrebi prilagodite toleranci na zdravljenje vsakega posameznega bolnika.
Ceplene with IL-2 will help your immune system attack any remaining cancer cells after a previous cancer treatment. 
Zdravljenje z zdravilom Ceplene v kombinaciji z IL-2 bo vašemu imunskemu sistemu pomagalo napasti preostale rakave celice po predhodnem zdravljenju raka.
• The active substance is histamine dihydrochloride. 
• Učinkovina je histaminijev diklorid.
ROS are known to limit the anti-leukaemic effects of lymphocyte activators such as IL-2, by triggering dysfunction and death by apoptosis in NK cells and T cells. 
Znano je, da kisikove reaktivne vrste (ROS) omejujejo protilevkemične vplive limfocitnih aktivatorjev, kot je IL-2, s sprožanjem disfunkcije in smrti z apoptozo pri celicah ubijalkah (NK) in T celicah.