natgillin/translations-raw huggingface dataset:
Increased plasma concentrations were, however, observed in individual subjects. 
Pri posameznikih so opazili zvišane koncentracije zdravila v plazmi.
On the outer package you can write the date and time you applied the patch. 
Na zunanjo ovojnino lahko zapišete datum in uro namestitve.
While waiting for the doctor, keep the person awake by talking to or shaking her/him now and then. 
Medtem ko čakate na zdravnika poizkusite obdržati bolnika v budnem stanju tako, da se z njim pogovarjate, ga občasno stresite.
They have high affinity to opioid receptors with relatively low intrinsic activity and therefore partially antagonise the analgesic effect of fentanyl and may induce withdrawal symptoms in opioid dependant patients (see also section 4.4). 
Ker imajo visoko afiniteto za opioidne receptorje z zelo nizko intrinzično aktivnostjo tako delno nasprotujejo analgetičnemu učinku fentanila in lahko povzročijo pojav odtegnitvenih simptomov (glejte poglavje 4.4).
The painkiller, fentanyl, slowly passes from the patch, through the skin and into the body. 
Analgetik fentanil počasi prehaja iz obliža skozi kožo v telo.
Patients with myasthenia gravis 
Bolniki z miastenijo gravis
respiratory depression, apnoea. 
respiratorna depresija, apneja
Regarding breast-feeding, section 4.6 of the proposed SPC reads: “Fentanyl is excreted into breast milk and may cause sedation and respiratory depression in the breastfed infant. 
V zvezi z dojenjem se poglavje 4.6 predlaganega povzetka glavnih značilnosti zdravila glasi: „Fentanil se izloča v materino mleko in utegne povzročati sedacijo in respiratorno depresijo pri dojenih dojenčkih.
General disorders and administration site conditions Rare: 
Splošne motnje in težave na mestu aplikacije Redki:
The need to perform a bioequivalence study with the highest strength and a valid study with replicate design was discussed. 
Obravnavana je bila potreba po izvedbi bioekvivalenčne študije z največjo jakostjo in veljavne študije na podlagi ponovitvenega načrta.
Both the lowest effective fentanyl concentration and the concentration causing adverse reactions will increase with the development of increasing tolerance. 
Najnižja učinkovita koncentracija fentanila in koncentracija pri kateri nastopijo možni neželeni učinki se lahko pri razvoju tolerance zvišata.
When changing over from oral or parenteral opioids to fentanyl treatment, the initial dosage should be calculated as follows: 
Ob prehodu s peroralnih ali parenteralnih opioidov na zdravljenje s fentanilom izračunajte začetni odmerek, kot je opisano v nadaljevanju:
Patients with fever/external heat 
Zvišana telesna temperatura/zunanji viri toplote
Switching from other opioids 
Prehod iz drugega zdravljenja z opioidi
Finally, regarding the demonstration of bioequivalence, the discussions pertained to the deviations to the guideline “Note for guidance on modified release oral and trans-dermal dosage forms: section II: pharmacokinetic and clinical evaluation- (CPMP/EWP/280/96)”. 
Razprava v zvezi z dokazovanjem bioekvivalence se je nanašala na odstopanje od smernice „Navodila za peroralne in transdermalne farmacevtske oblike s prirejenim sproščanjem: poglavje II: farmakokinetično in klinično vrednotenje (CPMP/EWP/280/96)“.
However, studies of fentanyl transdermal patch in elderly patients demonstrated fentanyl pharmacokinetics which did not differ significantly from young patients although serum concentrations tended to be higher. 
Študije transdermalnih obližev fentanila pri starejših bolnikih so pokazale, da farmakokinetika fentanila ni bila bistveno drugačna kot pri mlajših bolnikih, čeprav so koncentracije v serumu bile višje.
Psychiatric disorders Very common: somnolence. 
Psihiatrične motnje Zelo pogosti: zaspanost Pogosti:
About 9 % of the dose is recovered in the faeces, primarily as metabolites. 
V blatu se izloči približno 9 % odmerka, zlasti v obliki presnovkov.
Fentanyl-ratiopharm should be used with caution in patients who may be particularly susceptible to the intracranial effects of CO2 retention such as those with evidence of increased intracranial pressure, impaired consciousness or coma. 
Fentanyl-ratiopharm uporabljajte še posebej previdno pri bolnikih, občutljivih na učinke intrakranialnega zadrževanja ogljikovega dioksida, na primer pri tistih, pri katerih so se v preteklosti že pojavili povišan intrakranialni pritisk, stanje zmanjšane zavesti ali koma.
Oral administration of ritonavir (one of the most potent CYP3A4 inhibitors) reduced the clearance of intravenous fentanyl by two thirds and doubled the halflife. 
Peroralna aplikacija ritonavira (eden najmočnejših zaviralcev encima CYP3A4) je zmanjšala očistek intravensko danega fentanila za dve tretjini in podvojila razpolovni čas.
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER 
Ime in naslov imetnika dovoljenja za promet:
Uncommon: tremor, paraesthesia, speech disorder. 
tremor, paraestezija, motnje govora
What Fentanyl-ratiopharm is and what it is used for Before you use Fentanyl-ratiopharm How to use Fentanyl-ratiopharm Possible side effects 
Kaj je zdravilo Fentanyl-ratiopharm in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Fentanyl-ratiopharm Kako jemati zdravilo Fentanyl-ratiopharm Možni neželeni učinki
The Composite foil containing the following layers from outside to inside: coated Kraft paper, low density polyethylene foil, aluminium foil, Surlyn (thermoplastic ethylene-methacrylic acid copolymer). 
Sestava plasti od zunaj na vznoter: kraft papir, polietilenska folija nizke gostote, folija iz aluminija, Surlyn (termoplastični kisli etilenmetakrilni kopolimer).
The patches should not be cut into smaller parts, because the quality, efficacy and safety of such divided patches have not been demonstrated. 
Transdermalnih obližev ne smete razrezati na manjše kose, ker podatkov o kvaliteti, učinkovitosti in varnosti tako deljenih obližev ni.
If these medicines are taken together this may enhance their toxicity. 
Ta zdravila lahko povečajo toksičnost zdravljenja.
Chronic pulmonary disease 
Kronična pljučna bolezen
Biotransformation 
Biološka transformacija:
The concomitant use of buprenorphine, nalbuphine or pentazocine is not recommended. 
Ne priporočamo sočasne uporabe buprenorfina, nalbufina ali pentazocina.
Itraconazole (a potent CYP3A4 inhibitor) at 200 mg/day given orally for four days had no significant effect on the pharmacokinetics of intravenous fentanyl. 
Peroralna uporaba itrakonazola (močnega zaviralca encima CYP3A4) v dnevnih odmerkih 200 mg in v trajanju 4 dni ni znatno vplivala na farmakokinetiko intravensko uporabljenega fentanila.
Other signs and symptoms of overdose are drowsiness, low body temperature, slow heart rate, decreased muscle tone, deep sedation, loss of muscle co-ordination, constriction of the pupils and convulsions. 
Drugi znaki in simptomi prevelikega odmerjanja so zaspanost, nizka telesna temperature, počasen utrip srca, zmanjšan tonus mišic, globoka sedacija, izguba koordinacije delovanja mišic, zoženje zenic in krči.
Uncommon: tachycardia, bradycardia. 
tahikardija, bradikardija
- If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. 
- Če katerikoli neželeni učinek postane resen ali, če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, obvestite svojega zdravnika ali farmacevta.
After the first application of Fentanyl-ratiopharm, serum fentanyl concentrations increase gradually, generally levelling off between 12 and 24 hours, and remaining relatively constant for the remainder of the 72-hour application period. 
Po prvi uporabi obližev Fentanyl-ratiopharm koncentracija zdravila v serumu počasi narašča, po 12 do 24 urah se stabilizira in ostane razmeroma stabilna še ves preostali čas 72-urnega obdobja uporabe.
If you wish to interrupt or stop the treatment, you should always talk to your doctor about the reasons for discontinuation and your continued treatment. 
Če želite zdravljenje prekiniti ali ustaviti, se o razlogih za to vedno predhodno posvetujte s svojim zdravnikom.
Simultaneous use of Fentanyl-ratiopharm and alcoholic beverages increases the risk of severe adverse reactions, and may cause breathing difficulties, a fall of blood pressure, profound sedation and coma. 
Sočasno uživanje alkohola in uporaba obližev Fentanyl-ratiopharm poveča tveganje za hude neželene učinke, ki lahko povzročijo težave s dihanjem, padec krvnega tlaka, globoko sedacijo in komo.
Fentanyl-ratiopharm should not be used during pregnancy and breast-feeding unless clearly necessary. 
Obliži Fentanylratiopharm se med nosečnostjo in dojenjem ne uporabljajo razen, če je to nujno potrebno.
Studies have shown that almost all patients, despite treatment with a fentanyl patch, require supplemental treatment with potent rapid-release medicinal products to arrest breakthrough pain. 
Študije so pokazale, da je skoraj pri vseh bolnikih, kljub zdravljenju z obliži fentanila, v primeru t. i. "preboja bolečine", potrebno dodatno zdravljenje z močnimi, hitro delujočimi zdravili proti bolečinam.
MAO-inhibitors have been reported to increase the effect of narcotic analgesics, especially in patients with cardiac failure. 
Zaviralci monoaminooksidaze (MAO-inhibitorji) povečajo učinek narkotičnih analgetikov, še posebej pri bolnikih z boleznimi srca.
In very elderly or weak patients, it is not recommended to initiate an opioid treatment with Fentanylratiopharm, due to their known susceptibility to opioid treatments. 
Pri zelo starih ali šibkih bolnikih zdravljenje z obliži Fentanyl-ratiopharm ni priporočljivo zaradi njihove občutljivosti na zdravljenje z opioidnimi analgetiki.
Each transdermal patch is packed in a separate sachet. 
Transdermalni obliži so pakirani posamezno v zaščitne blazinice.
Skin rash and skin reddening will usually disappear within one day after the patch has been removed. 
Kožni izpuščaj in rdečica kože ponavadi izgineta dan po odstranitvi obliža.
The CNS depressants mentioned above include: - opioids - anxiolytics and tranquilizers - hypnotics - general anaesthetics - phenothiazines - skeletal muscle relaxants - sedating antihistamines - alcoholic beverages 
Zaviralci osrednjega živčnega sistema omenjeni zgoraj vključujejo: - opioide - anksiolitike - hipnotike - splošne anestetike - fenotiazine - mišične relaksante - sedativne antihistaminike - in alkoholne pijače
The symptoms of fentanyl overdose are an extension of its pharmacological actions, e.g. lethargy, coma, respiratory depression with Cheyne-Stokes respiration and/or cyanosis. 
Znaki prevelikega odmerjanja so povečani farmakološki učinki fentanila, kot so stupor, koma, respiratorna depresija s Cheyne-Stokesovim dihanjem in/ali cianoza.
For all practical purposes by the second 72-hour application, a steady state serum concentration is reached and is maintained during subsequent applications of a patch of the same size. 
Po 72urni uporabi je v serumu doseženo stanje dinamičnega ravnovesja, ki se vzdržuje z nadaljno uporabo obližev enake velikosti.
In addition, the CHMP recommends including the following information in section 4.4 of the SPC: 
Nadalje CHMP predlaga, da se v poglavje 4.4 povzetka glavnih značilnosti zdravila vključi naslednja informacija:
If any of the following serious, very rare side effects occur your should discontinue treatment and immediately contact your doctor or visit a hospital: severe respiratory depression (severe breathlessness, rattling breath) or complete block of the digestion channel (convulsive pain, vomiting, flatulence). 
Če opazite katere koli od naštetih resnih, zelo redkih neželenih učinkov, takoj prenehajte z zdravljenjem in o tem nemudoma obvestite svojega zdravnika ali nemudoma obiščite najbližjo bolnišnico: omejeno sposobnost dihanja (huda depresija dihanja) ali zaporo prebavnega trakta (krče z bolečinami, bruhanje, napenjanje in plini).
Transdermal fentanyl release (micrograms/h) 
Transdermalno sproščanje fentanila (mikrogrami/h)
Signs of toxicity are deep sedation, ataxia, miosis, convulsions and respiratory depression, which is the main symptom. 
Znaki zastrupitve so globoka sedacija, ataksija, mioza, epileptični napadi in respiratorna depresija, ki je najpomembnejši simptom.
Directly after removal from the pack and the release liner, the patch is applied to a non-hairy area of skin on the upper body (chest, back, upper arm). 
Takoj potem, ko odstranite ovojnino, morate transdermalni obliž namestiti na neporaščeno kožo na zgornjem delu telesa (prsni koš, hrbet, nadlahet).
By combining several transdermal patches, a fentanyl release rate of over 100 micrograms/h can be achieved. 
S kombinacijo večih transdermalnih obližev lahko dosežemo hitrost sproščanja fentanila prek 100 mikrogramov/h.
ANNEX II SCIENTIFIC CONCLUSIONS AND GROUNDS FOR AMENDMENT OF THE SUMMARY(IES) OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET PRESENTED BY THE EMEA 
DODATEK II ZNANSTVENI ZAKLJUČKI IN PODLAGA ZA DOPOLNILO POVZETKA(OV) GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJA IN NAVODILA ZA UPORABO, KI JIH JE PREDSTAVILA EVROPSKA AGENCIJA ZA ZDRAVILA
Therefore, fentanyl should not be used within 14 days after discontinuation of treatment with MAO-inhibitors. 
Zato fentanila ne uporabljajte 14 dni po ukinitvi zdravljenja z zaviralci monoaminooksidaze.
4.6 Pregnancy and lactation 
Nosečnost in dojenje
Fentanyl is metabolized primarily in the liver via CYP3A4. 
Fentanil se presnavlja predvsem v jetrih z encimom CYP3A4.
Like all medicines, Fentanyl-ratiopharm can cause side effects, although not everybody gets them. 
MOŽNI NEŽELENI UČINKI Kot vsa zdravila imajo lahko tudi obliži Fentanyl-ratiopharm neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
If this should occur - remove the patches and contact a doctor immediately. 
V tem primeru je treba obliž takoj odstraniti in o tem obvestiti zdravnika.
Patients with hepatic or renal impairment should be observed carefully and the dose reduced if necessary (see section 4.4). 
Bolnike z okvaro jeter ali ledvic je treba skrbno opazovati in odmerek po potrebi zmanjšati (glejte poglavje 4.4).
If traces of the transdermal patch remain on the skin after its removal, these can be cleaned off using copious amounts of soap and water. 
Ostanke obliža na koži po odstranitvi lahko odstranimo s pomočjo zadostne količine vode in mila.
This applies, for example, to: - medicines used for treating anxiety (tranquillisers) - medicines used for treating depression (antidepressants) - medicines used for treating psychological disorders (neuroleptics) - anaesthetics, if you think you are going to have an anaesthetic, tell the doctor or dentist that you are using Fentanyl-ratiopharm - medicines used for treating sleep disorders (hypnotics, sedatives) - medicines used for treating allergies or travel sickness (antihistamines/antiemetics) - other strong-acting painkillers (opioids) - alcohol 
Med ta zdravila sodijo: - zdravila za zdravljenje anksioznosti (pomirjevala) - zdravila za zdravljenje depresije (antidepresivi) - zdravila za zdravljenje psiholoških bolezni (nevroleptiki) - anestetiki, če boste podvrženi posegu za katerega bo potrebna anestezija, svojemu zdravniku ali zobozdravniku povejte, da uporabljate obliže Fentanyl-ratiopharm - zdravila proti nespečnosti (hipnotiki, pomirjevala) - zdravila proti alergijam ali potovalni bolezni (antihistaminiki/antiemetiki) - močna zdravila proti bolečinam (opioidi) - in alkoholne pijače
No alcohol or other solvents must be used for cleaning, as these may penetrate the skin due to the effect of the patch. 
Alkohola in drugih topil zato ne smemo uporabiti, ker lahko zaradi prejšnjega delovanja obliža le ta prehajata v kožo.
Prolonged use of Fentanyl-ratiopharm can cause physical dependence. 
Pri dolgotrajni uporabi obližev Fentanyl-ratiopharm se lahko pojavi psihična odvisnost.
The first of these are transient and their cause should be investigated if symptoms persist. 
Prvi le teh so prehodni, v kolikor pa ne izzvenijo je potrebno raziskati druge morebitne vzroke njihovega nastanka.
The concomitant use of other CNS depressants may produce additive depressant effects and hypoventilation, hypotension as well as profound sedation or coma may occur. 
Sočasna uporaba drugih zaviralcev osrednjega živčnega sistema ima lahko dodaten depresiven učinek in lahko povzroči hipoventilacijo, hipotenzijo in močno sedacijo ali komo.
If you get pregnant during treatment with Fentanyl-ratiopharm, consult your doctor. 
Če med uporabo obližev Fentanyl-ratiopharm zanosite, se o tem posvetujte s svojim zdravnikom.
Fentanyl-ratiopharm is a medicinal product that could be life-threatening to children. 
Obliži Fentanyl-ratiopharm so zdravilo, ki v primeru zaužitja lahko ogrozijo življenje otrok.
Following administration of Fentanyl-ratiopharm, fentanyl is continuously absorbed through the skin over a period of 72 hours. 
Po pritrditvi obliža Fentanyl-ratiopharm se fentanil 72 ur absorbira skozi kožo.
The safety of fentanyl in pregnancy has not been established. 
Varnost uporabe transdermalnih obližev s fentanilom v nosečnosti ni bila potrjena.
Irregular heartbeat, dilated blood vessels, hiccup, water retention in the tissues, feeling cold. 
neredno bitje srca, razširjene krvni žile, kolcanje, zadrževanje vode v tkivih, občutek mraza.
If you forget, then change your patch as soon as you remember. 
Če ste pozabili zamenjati obliž, to storite takoj, ko se na to spomnite.
Breakthrough pain 
“Preboj bolečine”
If you take concomitantly medicines that affect brain function it is more likely that you'll have side effects especially difficulty in breathing. 
Če sočasno uporabljate druga zdravila z delovanjem na osrednji živčni sistem je verjetneje, da se bodo pri vas pojavili neželeni učinki, predvsem težave z dihanjem.
Pay special attention to see that the patch sticks properly at the edges. 
Posebej bodite pozorni na robove obliža, ki morajo biti dobro prilepljeni.
Pack containing 3, 5, 10 or 20 transdermal patches 
Škatle s 3, 5, 10, ali 20 transdermalnimi obliži
Duration of administration 
Trajanje odmerjanja
If you have been using the same dose of Fentanyl-ratiopharm for a longer period of time, your doctor may decide that you are permitted to drive and use dangerous machines. 
Če ste uporabljali transdermalne obliže Fentanyl-ratiopharm že dlje časa, vam vaš zdravnik lahko dovoli vožnjo ali upravljanje strojev.
Other symptoms may be hypothermia, decreased muscle tonus, bradycardia, hypotension. 
Drugi možni znaki so hipotermija, izguba mišične tenzije, bradikardija in hipotenzija.
Data obtained with intravenous fentanyl in patients with renal failure suggest that the volume of distribution of fentanyl may be changed by dialysis. 
Podatki, pridobljeni pri bolnikih z ledvično okvaro, ki so fentanil prejemali intravensko, kažejo, da dializa lahko spremeni volumen porazdelitve fentanila.
As a general rule, the discontinuation of opioid analgesia should be gradual, in order to prevent withdrawal symptoms (nausea, vomiting, diarrhoea, anxiety and muscular tremor). 
Po splošnih pravilih moramo zdravljenje z opioidi ukinjati postopoma, da tako preprečimo pojav odtegnitvenih simptomov (kot so slabost, bruhanje, driska, tesnoba in mišični tremor).
Please fill in date and time when you put your patch on. 
Prosimo zabeležite datum in uro aplikacije obliža.
Patients stabilized on a specific dosage will not necessarily be restricted. 
Bolnikom, ki so stabilizirani na določenem odmerku, ni nujno prepovedati vožnje ali upravljanja strojev.
Eye disorders Very rare: 
Očesne bolezni Zelo redki:
Significant increases in body temperature can potentially increase fentanyl absorption rate. 
Ob znatnem zvišanju telesne temperature se lahko poveča hitrost absorbcije fentanila.
Uncommon: euphoria, amnesia, insomnia, hallucinations, agitation. 
evforija, amnezija, nespečnost, halucinacije, razdražljivost
Any unused medicinal product should be discarded or returned to the pharmacy. 
Neuporabljene obliže je treba zavreči ali vrniti v lekarno.
If patients with renal impairment receive transdermal fentanyl they should be observed carefully for signs of fentanyl toxicity and the dose reduced if necessary. 
Če bolniki z okvarjenim delovanjem ledvic prejemajo transdermalne obliže fentanila, je treba pozorno spremljati znake toksičnosti fentanila in po potrebi zmanjšati odmerek.
The skin area to which the patch is applied should be free of microlesions (e.g. due to irradiation or shaving) and skin irritation. 
Predel kože kamor se namesti obliž ne sme biti poškodovan (mikrolezije zaradi npr. obsevanja ali britja) ali razdražen.
All dosages given in the table are equivalent in analgesic effect to 10 mg parenteral morphine. 
Preglednica 1: Ustrezni analgetični učinek zdravil Vsi, v tabeli navedeni odmerki ustrezajo analgetičnemu učinku 10 mg parenteralnega odmerka morfina.
Fentanyl should only be used during pregnancy when clearly necessary. 
Zato fentanila ne smete uporabljati med nosečnostjo razen, če je nujno potrebno.
headache, visual disturbances), changes in your state of consciousness or loss of consciousness or coma - slow irregular heartbeat (bradyarrhythmias) - myasthenia gravis (a disease causing tiredness and weakness of the muscles) 
(npr. glavobol, motnje vida), motnje stanja zavesti ali izgubo zavesti ali komo - počasen in nepravilen utrip srca - miastenija gravis (bolezen, ki povzroča šibkost mišic in utrujenost)
The dose should be titrated individually until analgesic efficacy is attained. 
Odmerek titrirajte za vsakega posameznega bolnika, dokler ne dosežete analgetičnega učinka.
Absorption 
Absorpcija:
Generalised acute allergic reactions with a fall in the blood pressure and/or difficulty in breathing (anaphylactic reactions), delusional ideas, states of excitement, loss of physical strength, depression, anxiety, confusion, sexual dysfunction, withdrawal symptoms, coordination disturbances, seizures (including clonic and grand mal seizures), diminished visual acuity, impaired respiration (respiratory depression), respiratory arrest (apnoea), painful bloating, block of the digestion channel, urinary bladder pain, passing water less than normal (reduced urine excretion). 
generalizirane alergične reakcije s padcem krvnega tlaka in/ali težko dihanje (anafilaktične reakcije), privide, stanje vzdraženosti, izguba fizične moči, depresija, tesnoba, zmedenost, motnje spolnih funkcij, odtegnitveni znaki, motnje koordinacije, epileptični napadi (klonični in grand mal napadi), zmanjšana ostrina vida, motnje dihanja (depresija dihanja), zastoj dihanja (apnena), boleče napenjanje, zapora prebavnega trakta, bolečine v mehurju, zmanjšano izločanje urina.
Due to limited experience in children under 12 years of age, Fentanyl-ratiopharm should be used in this age group only after careful consideration has been given to the benefit versus risk ratio. 
Zaradi omejenih izkušenj uporabe Fentanyl-ratiopharm pri otrocih mlajših od 12 let ne priporočamo, razen v primerih pazljivega ovrednotenja razmerja med koristmi in tveganji zdravljenja.
It is not recommended to use those together with Fentanyl-ratiopharm. 
Uporaba teh zdravil skupaj z obliži Fentanyl-ratiopharm ni priporočena.
delusional ideas, states of excitement, asthenia, depression, anxiety, confusion, sexual dysfunction, withdrawal symptoms. 
deluzije, stanja vzburjenosti, astenija, depresija, anksioznost, zmedenost, seksualna funkcionalna motnja, simptomi odtegnitve
3 transdermal patches 5 transdermal patches 10 transdermal patches 20 transdermal patches 
3 transdermalni obliži 5 transdermalnih obližev 10 transdermalnih obližev 20 transdermalnih obližev
Due to the polymer matrix and the diffusion of fentanyl through the skin layers, the release rate remains relatively constant. 
Polimerni matriks in difuzija fentanila skozi kožo omogoča sproščanje z razmeroma enakomerno hitrostjo.
Combined use of ritonavir or other potent CYP3A4-inhibitors with transdermal fentanyl is not recommended, unless the patient is carefully observed. 
Sočasna uporaba močnih zaviralcev encima CYP3A4 in transdermalnega fentanila zato ni priporočena razen, če pri bolniku pozorno spremljate znake neželenih učinkov.