natgillin/translations-raw huggingface dataset:
What Cystadane is and what it is used for What do you need to know before you take Cystadane How to take Cystadane 
Kaj je zdravilo Cystadane in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Cystadane Kako jemati zdravilo Cystadane Možni neželeni učinki
The recommended dose in children and adults is 100mg/kg/day divided in 2 dosesper day. 
Priporočeni odmerek pri otrocih in odraslih je 100 mg/kg/dan, razdeljen na 2 odmerka.
Uncommon: agitation, irritability 
Občasne: agitiranost, razdražljivost
Do not use this medicine after the expiry date which is stated on the bottle label and the carton after EXP. 
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini steklenice in škatli poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
It is not known whether betaine anhydrous is excreted in human milk (although its metabolic precursor, choline, occurs at high levels in human milk). 
Ni znano, ali se brezvodni betain izloča v materino mleko (čeprav se njegov presnovni prekurzor, holin, v materinem mleku pojavlja v visokih koncentracijah).
Methionine level can be related to swelling in the brain (cerebral swelling), which may affect up to 1 in 100 people (frequency uncommon). 
Raven metionina je lahko povezana z oteklino možganov (cerebralna oteklina), ki se lahko pojavi pri 1 od 100 bolnikov (občasna pogostnost).
Most of these patients were also receiving other treatments such as vitamin B6 (pyridoxine), vitamin B12 (cobalamin) and folate with variable biochemical responses. 
Večina teh bolnikov je prejemala tudi druga zdravila, na primer vitamin B6 (piridoksin), vitamin B12 (kobalamin) in folat, z variabilnimi biokemičnimi odzivi.
- If symptoms of cerebral oedema recur after re-introduction of treatment then betaine anhydrous therapy should be discontinued indefinitely. 
- Če se po ponovni uvedbi zdravljenja simptomi možganskega edema spet pojavijo, je treba zdravljenje z brezvodnim betainom za vedno opustiti.
If you stop taking Cystadane 
Če ste prenehali jemati zdravilo Cystadane
Cystadane contains betaine anhydrous which is intended to be an adjunctive treatment of homocystinuria, an inherited (genetic) disease where the amino acid methionine cannot be broken down completely by the body. 
Zdravilo Cystadane vsebuje brezvodni betain, ki je namenjen dodatnemu zdravljenju homocistinurije, podedovane (genetske) bolezni, pri kateri telo ne more razgraditi aminokisline metionina.
180 g of oral powder. 
180 g peroralnega praška.
Mix the measured dose of powder with water, juice, milk, formula or food until completely dissolved and ingest immediately after mixing. 
Zmešajte izmerjen odmerek praška z vodo, sadnim sokom, mlekom, formulo ali hrano, da se bo popolnoma raztopil, in ga po mešanju takoj zaužijte.
Cystadane has no or negligible influence on the ability to drive and use machines. 
Zdravilo Cystadane nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
To minimise the risk of potential drug interactions, it is advisable to leave 30 minutes between the intake of betaine anhydrous and amino acids mixtures and/or medicinal products containing vigabatrin and GABA analogues (see section 4.5). 
Da se nevarnost možnih interakcij med zdravili čim bolj zmanjša, priporočamo, naj med zaužitjem brezvodnega betaina in mešanic aminokislin ali zdravil, ki vsebujejo vigabatrin in analoge GABA ali obojega, mine 30 minut (glejte poglavje 4.5).
Do not take Cystadane If you are allergic to betaine anhydrous. 
Ne jemljite zdravila Cystadane če ste vi ali vaš otrok alergični na brezvodni betain.
If you are treated with Cystadane and with an amino-acid mixture and if you need to take other medicines at the same time, leave 30 minutes between the intake (see “section “Other medicines and Cystadane”). 
Če se zdravite z zdravilom Cystadane in z mešanico aminokislin in morate istočasno jemati še druga zdravila, druga zdravila vzemite šele pol ure ali več po tistem, ko vzamete Cystadane in mešanico aminokislin (glejte poglavje »Druga zdravila in zdravilo Cystadane«).
Because of lack of data, caution should be exercised when prescribing Cystadane to breast-feeding women. 
Zaradi pomanjkanja podatkov je pri predpisovanju zdravila Cystadane doječim materam potrebna previdnost.
Experience with betaine anhydrous therapy in patients with renal insufficiency or non-alcoholic hepatic steatosis has demonstrated no need to adapt the dose regimen of Cystadane. 
Izkušnje z zdravljenjem z brezvodnim betainom pri bolnikih z insuficienco ledvic ali nealkoholno steatozo jeter so pokazale, da pri teh bolnikih sheme odmerjanja zdravila Cystadane ni treba prilagajati.
Caution should be exercised with up-titrating doses for patients with CBS deficiency due to the risk for hypermethioninaemia. 
Pri titriranju odmerka navzgor pri bolnikih s pomanjkanjem CBS je potrebna previdnost zaradi tveganja za hipermetioninemijo.
If you are taking amino-acid mixture or medicines such as vigabatrin or Gaba analogues (medicine used to treat epilepsy), please tell your doctor as they might interact with your treatment with Cystadane. 
Če jemljete mešanico aminokislin ali zdravila, kakršna sta vigabatrin ali zdravila z zdravilnimi učinkovinami, podobnimi GABA (zdravilo za zdravljenje epilepsije), to povejte zdravniku, ker bi ta zdravila lahko vplivala na vaše zdravljenje z zdravilom Cystadane.
Uncommon: brain oedema* 
Občasna: možganski edem*
Monitoring plasma homocysteine levels has demonstrated that the onset of action of betaine anhydrous occurred within several days and that a steady-state response was achieved within one month. 
S spremljanjem koncentracije homocisteina v plazmi so pokazali, da brezvodni betain začne delovati čez nekaj dni in da se odziv v stanju dinamičnega ravnovesja doseže v enem mesecu.
The use of Cystadane together with other treatments such as vitamin B6, vitamin B12, folate and a specific diet aims to reduce the elevated homocysteine levels in your body. 
Cilj uporabe zdravila Cystadane skupaj z drugimi zdravili in vrstami zdravljenja, kot so vitamin B6, vitamin B12, folat in posebna dieta, je znižanje zvišane koncentracije homocisteina v vašem telesu.
• take a heaped spoonful of powder out of the bottle 
• Vzemite zvrhano merilno žličko praška iz steklenice.
Based on in vitro data, betaine anhydrous might interact with amino acids mixtures and medicinal products containing vigabatrin and GABA analogues. 
Na podlagi podatkov, pridobljenih in vitro, bi se lahko pojavile interakcije brezvodnega betaina z mešanicami aminokislin in zdravil, ki vsebujejo vigabatrin in analoge GABA.
Betaine anhydrous acts as a methyl group donor in the remethylation of homocysteine to methionine in patients with homocystinuria. 
Brezvodni betain deluje kot donator metilnih skupin pri ponovnem metiliranju homocisteina v metionin pri bolnikih s homocistinurijo.
Driving and using machines Cystadane has no or negligible influence on the ability to drive and use machines. 
Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Cystadane nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
Cystadane treatment should be supervised by a physician experienced in the treatment of patients with homocystinuria. 
Zdravljenje z zdravilom Cystadane naj nadzoruje zdravnik, ki ima izkušnje z zdravljenjem bolnikov s homocistinurijo.
Each pack contains 1 bottle with 180 g of powder and three measuring spoons. 
Vsaka škatlica vsebuje 1 plastenko s 180 g praška in tri merilne žličke.
Description of selected adverse reactions *Uncommon cases of severe cerebral oedema and hypermethioninemia were reported within 2 weeks to 6 months of starting betaine anhydrous therapy in patients with CBS deficiency, with complete recovery after treatment discontinuation. 
Opis izbranih neželenih učinkov * Pri bolnikih s pomanjkanjem CBS so poročali o občasnih primerih težkega možganskega edema in hipermetioninemije 2 tednih do 6 mesecih o začetku zdravljenja z brezvodnim betainom; po prekinitvi zdravljenja so bolniki povsem okrevali.
Cystadane should be used as supplement to other therapies such as vitamin B6 (pyridoxine), vitamin B12 (cobalamin), folate and a specific diet. 
Zdravilo Cystadane naj se uporablja kot dodatek drugim zdravilom, na primer vitaminu B6 (piridoksin), vitaminu B12 (kobalamin), folatu in posebni dieti.
Late detection of homocystinuria in symptomatic state is responsible for residual morbidity due to irreversible damage to connective tissue (ophtalmological, skeletal) that cannot be corrected by further therapy. 
Pozno odkritje homocistinurije, ko je bolezen že v simptomatskem stadiju, je odgovorno za rezidualno obolevnost zaradi ireverzibilnih okvar vezivnega tkiva (oftalmoloških, skeletnih), ki jih nadaljnje zdravljenje ne more popraviti.
HDPE bottles with a child resistant closure. 
Plastenke iz HDPE s pokrovčkom z za otroke varno zaporko.
EXP Shelf life after the first opening: 3 months. 
EXP Rok uporabnosti po prvem odpiranju: 3 mesece.
Absorption The absolute bioavailability of betaine anhydrous has not been determined. 
Absolutne biološke uporabnosti brezvodnega betaina niso ugotovili.
180 g of oral powder and three measuring spoons. 
180 g peroralnega praška in tri merilne žličke.
BOTTLE LABEL 
NALEPKA NA STEKLENICI
A. MANUFACTURERs RESPONSIBLE FOR BATCH RELEASE 
A. IZDELOVALCI, ODGOVORNI ZA SPROŠČANJE SERIJ
Each carton contains one bottle and three measuring spoons. 
Škatla vsebuje eno plastenko in tri merilne žličke.
If you notice side effects like headaches, vomiting or a change in your vision and you are of the homocystinuria subtype called CBS (cystathionine beta-synthase deficiency), please contact your doctor immediately, they could be signs of a swelling in the brain (cerebral oedema). 
Če opazite neželene učinke, kot so glavoboli, bruhanje ali spremembe vida, in imate podtip homocistinurije, ki je posledica pomanjkanja encima CBS (cistationin beta-sintaze), se nemudoma obrnite na svojega zdravnika, ker bi to lahko bili znaki možganske otekline (cerebralnega edema).
Lightly shake the bottle before opening. 
• Rahlo pretresite steklenico, preden jo odprete.
This will give the following doses: small measure 100 mg, middle size measure 150 mg and large measure 1 g of betaine anhydrous. 
Tako boste dobili naslednje odmerke: mala merilna žlička 100 mg, srednja merilna žlička 150 mg in velika merilna žlička 1 g brezvodnega betaina.
How to take Cystadane 
Kako jemati zdravilo Cystadane
It is recommended that a heaped measuring spoon is removed from the bottle and a flat surface e.g. base of a knife is drawn across the top of the measure. 
Priporočamo, da iz plastenke vzamete zvrhano merilno žličko praška, nato pa čeznjo potegnite z ravno površino, na primer z noževim rezilom.
Long-term carcinogenicity and reproductive toxicity studies have not been conducted on betaine anhydrous. 
Dolgoročnih študij kancerogenosti in vpliva na sposobnost razmnoževanja z brezvodnim betainom niso opravili.
Medicinal product subject to restricted medical prescription (see annex I: Summary of Product Characteristics, section 4.2) 
Predpisovanje in izdaja zdravila je le na recept s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
Gastrointestinal disorders like diarrhoea, nausea, vomiting, stomach discomfort and inflammation of the tongue may occur uncommonly (may affect up to 1 in 100 people). 
Prebavne motnje kot so driska, navzea, bruhanje, nelagodje v trebuhu in vnetje jezika se lahko pojavijo občasno (pri 1 od 100 bolnikov).
In CBS-deficient patients without dietary restriction of methionine, excessive accumulation of methionine has been observed. 
Pri bolnikih s pomanjkanjem CBS brez omejitve vnosa metionina s hrano so opazili čezmerno kopičenje metionina.
Betaine anhydrous has also been shown to increase plasma methionine and S-adenosyl methionine (SAM) levels in patients with MTHFR deficiency and cbl defects. 
Pokazali so tudi, da brezvodni betain zvišuje koncentracijo metionina in S-adenozilmetionina (SAM) v plazmi pri bolnikih s pomanjkanjem MTHFR in napakami cbl.
What Cystadane contains - The active substance is betaine anhydrous. 
Kaj vsebuje zdravilo Cystadane - Zdravilna učinkovina je brezvodni betain.
Biotransformation Betaine anhydrous is a methyl group donor 
Brezvodni betain je donor metilne skupine.
Betaine anhydrous was shown to lower plasma homocysteine levels in the three types of homocystinuria, i.e. CBS deficiency; MTHFR deficiency and cbl defect. 
Pokazali so, da brezvodni betain znižuje koncentracijo homocisteina v plazmi pri treh vrstah homocistinurije, in sicer pri pomanjkanju CBS, pomanjkanju MTHFR in napaki cbl.
Elevated homocysteine plasma levels are associated with cardiovascular events (such as thrombosis), osteoporosis, skeletal abnormalities, and optic lens dislocation. 
Zvišana koncentracija homocisteina v plazmi je povezana s kardiovaskularnimi dogodki, na primer trombozo, z osteoporozo, nenormalnostmi okostja in izpahom očesne leče.
Betaine anhydrous supplementation was shown to improve the metabolic abnormalities in the cerebrospinal fluid of patients with homocystinuria. 
Izkazalo se je, da dodajanje brezvodnega betaina izboljša presnovne nenormalnosti v cerebrospinalni tekočini bolnikov s homocistinurijo.
As cerebral oedema has also been reported in patients with hypermethioninemia, secondary hypermethioninemia due to betaine anhydrous therapy has been postulated as a possible mechanism of action. 
Ker so pri bolnikih s hipermetioninemijo poročali tudi o možganskem edemu, so domnevali, da je možni mehanizem delovanja sekundarna hipermetioninemija zaradi zdravljenja z brezvodnim betainom.
- If you have any further questions, ask your doctor or your pharmacist. 
- Če imate dodatna vprašanja, se posvetujte s svojim zdravnikom ali farmacevtom.
Three measuring spoons (green, blue, pink) dispense 100mg, 150mg or 1g of betaine anhydrous. 
Priložene so tri merilne žličke (zelena, modra, rožnata), s katerimi odmerimo 100 mg, 150 mg ali 1 g brezvodnega betaina.
- If any symptoms of cerebral oedema like morning headaches with vomiting and/or visual changes appear, plasma methionine level and compliance to the diet should be checked and treatment with Cystadane interrupted. 
- Če se pojavijo simptomi možganskega edema, na primer jutranji glavoboli z bruhanjem ali spremembami vida ali oboje, je treba preveriti koncentracijo metionina v plazmi, ugotoviti, ali se bolnik drži diete, in prekiniti zdravljenje z zdravilom Cystadane.
Unopened bottle: 3 years After the first opening: 3 months. 
Neodprta steklenica: 3 leta.
However, the dose should be individually titrated according to plasma levels of homocysteine and methionine. 
Vendar je treba odmerek titrirati glede na ravni homocisteina in metionina za vsakega bolnika posebej.
With a slow elimination rate (mean half life = 14 h, mean total body clearance, CL/F, = 84 ml/h/kg), 
Z majhno hitrostjo izločanja (povprečni razpolovni čas = 14 ur), povprečni celotni telesni očistek, CL/F = 84 ml/h/kg) je ledvični očistek zanemarljiv (5 % celotnega telesnega očistka), če predpostavimo 100-odstotno biološko uporabnost.
It is presented in bottles with child resistant closures. 
Na voljo je v plastenkah s pokrovčkom z za otroke varno zaporko.
Do not take a double dose to make up for forgotten doses. 
Če ste pozabili vzeti zdravilo zdravilo Cystadane Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
Each bottle contains 180 g of powder. 
Ena plastenka vsebuje 180 g praška.
Cystadane 1 g oral powder 
Cystadane 1 g peroralni prašek
Data on a limited number of exposed pregnancies indicate no adverse event of betaine anhydrous on pregnancy or on the health of the foetus/newborn child. To date, no other relevant epidemiologic data are available. 
Podatki, zbrani pri omejenem številu nosečnic, ki so bile izpostavljene zdravilu, ne kažejo na možnost škodljivih vplivov brezvodnega betaina na nosečnost ali zdravje zarodka/novorojenca.
After the first opening of the bottle, the medicine should be used within 3 months. 
Zdravilo morate porabiti v 3 mesecih od takrat, ko plastenko prvič odprete.
White crystalline free flowing powder. 
peroralni prašek Bel kristalen sipek peroralni prašek.
Uncommon cases of severe cerebral oedema associated with hypermethioninemia were reported with betaine anhydrous therapy in patients with CBS deficiency (see section 4.8). 
Pri bolnikih s pomanjkanjem CBS so poročali o občasnih primerih težkega možganskega edema, povezanega s hipermetioninemijo, po začetku zdravljenja z brezvodnim betainom (glejte poglavje 4.8).
Three measuring spoons are provided which dispense either 100 mg, 150 mg or 1 g of betaine anhydrous. 
Priložene so tri merilne žličke, s katerimi odmerimo 100 mg, 150 mg in 1 g brezvodnega betaina.
• pass the flat back of a knife over the top of the spoon 
• Potegnite čez merilno žličko z noževim rezilom.
• the middle size blue spoon measures 150 mg of betaine anhydrous powder ; 
• s srednjo žličko odmerite 150 mg betaina v obliki brezvodnega praška;
At high doses, a CNS depressant effect and irritation of the gastrointestinal tract was seen in rats. 
Pri podganah so pri velikih odmerkih ugotovili depresiven učinek na centralno živčevje in draženje prebavil.
In general, adverse reactions seen with betaine anhydrous therapy appeared to be not serious and are mainly related to the gastrointestinal system. 
Na splošno kaže, da neželeni učinki pri zdravljenju z brezvodnim betainom niso resni, in da se povečini našanajo na prebavila.
Gastrointestinal disorders like diarrhoea, glossitis, nausea, stomach discomfort, vomiting and dental disorders may occur uncommonly. 
Občasno se lahko pojavijo prebavne motnje kot so driska, glositis, navzea, nelagodje v trebuhu, bruhanje in bolezni zob.
How to store Cystadane 
Shranjevanje zdravila Cystadane
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum prve odobritve: 15 februar 2007
Shelf life after the first opening: 3 months. 
Rok uporabnosti po prvem odpiranju: 3 mesecev.
Tabulated list of adverse reactions 
Seznam neželenih učinkov v obliki tabele
Talk to your doctor or pharmacist before taking Cystadane. 
Pred začetkom jemanja zdravila Cystadane se posvetujte z zdravnikom ali farmacevtom.
Symptoms of cerebral oedema include morning headaches with vomiting and/or visual changes High increases in plasma methionine levels in a range from 1,000 to 3,000 µM were noted in these patients. 
Pri teh bolnikih so opazili močno zvišanje koncentracije metionina v plazmi, ki je bila med 1.000 in 3.000 µM.
1 g of powder contains 1 g of betaine anhydrous. 
1 g praška vsebuje 1 g brezvodnega betaina.
1 g of oral powder contains 1 g of betaine anhydrous. 
1 g peroralnega praška vsebuje 1 g brezvodnega betaina.
Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu/. 
Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/, kjer so na voljo tudi povezave do drugih spletnih strani o redkih boleznih in zdravljenju.
• the powder left in the spoon is one spoonful 
• V merilni žlički ostane za eno žličko praška.
What Cystadane looks like and contents of the pack Cystadane is a white crystalline free flowing powder. 
Zdravilo Cystadane je bel kristalen sipki prašek.
Cystadane 1 g oral powder Betaine anhydrous 
Cystadane 1 g peroralni prašek brezvodni betain
• the small green spoon measures 100 mg of betaine anhydrous powder; 
• z malo žličko odmerite 100 mg betaina v obliki brezvodnega praška;
Uncommon: diarrhoea, glossitis, nausea, stomach discomfort, vomiting Skin and subcutaneous tissue disorders Uncommon: hair loss, hives, skin odour abnormal Renal and urinary disorders 
Občasne: izpadanje las, koprivnica, nenormalen vonj kože
Contact your doctor or pharmacist before stopping. 
Preden prenehate, se obrnite na zdravnika ali farmacevta.
Homocystinuria is a disease caused by the accumulation of homocysteine which is not converted to cysteine and is characterised by formation of clots in the veins, bone weakness, and skeletal and crystalline lens abnormalities. 
Zanjo je značilno nastajanje strdkov v venah, šibkost kosti in nenormalnosti okostja in očesne leče.
Recordati Rare Diseases Immeuble "Le Wilson" 70, avenue du Général de Gaulle F-92800 Puteaux France 
Recordati Rare Diseases Immeuble “Le Wilson” 70, avenue du Général de Gaulle F - 92800 Puteaux Francija
Marketing Authorisation Holder Recordati Rare Diseases Immeuble “Le Wilson” 70, avenue du General de Gaulle F-92 800 Puteaux France 
Imetnik dovoljenja za promet z zdravilom Recordati Rare Diseases Immeuble “Le Wilson” 70, avenue du Général de Gaulle F - 92800 Puteaux
This overview was last updated in October 2019. 
Povzetek zdravila je bil nazadnje posodobljen oktobra 2019.
A single treatment is required however the full effect may only be seen 28 days later. 
Potrebno je eno samo zdravljenje, vendar pa se lahko učinek v celoti pokaže šele 28 dni pozneje.
Other information about Neptra 
Druge informacije o zdravilu Neptra
The European Medicines Agency decided that Neptra's benefits are greater than its risks and it can be authorised for use in the EU. 
Evropska agencija za zdravila je odločila, da so koristi zdravila Neptra večje od z njim povezanih tveganj in da se lahko odobri za uporabo v EU.
The inside of the ear should be cleaned and dry before treatment. 
Notranjost ušesa je treba pred zdravljenjem očistiti in posušiti.
Further information on Neptra can be found on the Agency's website: ema.europa.eu/medicines/veterinary/EPAR/neptra. 
Nadaljnje informacije o zdravilu Neptra so na voljo na spletni strani agencije: ema.europa.eu/medicines/veterinary/EPAR/neptra.
The contents of one tube are given into each infected ear. 
V vsako okuženo uho se nanese vsebina ene tube.
In case of accidental eye exposure, the eyes should be flushed thoroughly with water for 10 to 15 minutes. 
V primeru nenamernega stika z očmi je treba temeljito izpirati oči z vodo od 10 do 15 minut.
What benefits of Neptra have been shown in studies? 
Kakšne koristi zdravila Neptra so se pokazale v študijah?
Although no potential for skin irritation was indicated by studies, skin contact should be avoided. 
Čeprav študije niso pokazale možnosti draženja kože, se je treba izogibati stiku s kožo.
Neptra received a marketing authorisation valid throughout the EU on 10 December 2019. 
Zdravilo Neptra je pridobilo dovoljenje za promet, veljavno po vsej Evropski uniji, 10/12/2019.
Why is Neptra authorised in the EU? 
Zakaj je zdravilo Neptra odobreno v EU?
This was more effective than the control group of 27 dogs, which received a placebo (dummy treatment) and for which the reduction was 49%. 
To je bilo učinkovitejše kot pri kontrolni skupini 27 psov, ki so prejeli placebo (zdravilo brez učinkovine) in pri katerih se je klinična ocena zmanjšala za 49 %.
Two of the active substances in Neptra, florfenicol and terbinafine, act against possible causes of infection. 
Dve od učinkovin v zdravilu Neptra, florfenikol in terbinafin, učinkujeta proti mogočim vzrokom okužbe.
What are the risks associated with Neptra? 
Kakšna tveganja so povezana z zdravilom Neptra?
The third active substance, mometasone, is a corticosteroid, a medicine that reduces inflammation and pain associated with the infection. 
Tretja učinkovina, mometazon, je kortikosteroid, zdravilo, ki zmanjšuje vnetje in bolečino, ki sta povezana z okužbo.
It is therefore recommended that this medicine is applied only by veterinarians or under their close supervision and that measures are taken to reduce the risk (e.g. wearing safety glasses during treatment, massaging the ear canal well after application to ensure even distribution of product, restraining the dog after application). 
Zato se priporoča, da to zdravilo dajejo samo veterinarji ali da se uporablja pod njihovim neposrednim nadzorom in da se sprejmejo ukrepi za zmanjšanje tveganja (npr. uporaba zaščitnih očal pri dajanju zdravila, dobro masiranje ušesnega kanala po dajanju, da se zagotovi enakomerna porazdelitev zdravila, z omejevanjem gibanja psa po dajanju zdravila).