natgillin/translations-raw huggingface dataset:
Linagliptin and its main metabolite did not show a genotoxic potential. 
Linagliptin in njegov glavni presnovek nista delovala genotoksično.
Stop taking Jentadueto and contact a doctor or the nearest hospital immediately if you experience some of the symptoms of lactic acidosis, as this condition may lead to coma. 
Takoj prenehajte jemati zdravilo Jentadueto in se obrnite na zdravnika ali najbližjo bolnišnico, če se pojavijo nekateri od simptomov laktacidoze, saj lahko to stanje vodi v komo.
Metformin hydrochloride is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. 
Metforminijev klorid je bigvanid z antihiperglikemičnim učinkom, ki zmanjšuje osnovno in postprandialno glukozo v plazmi.
Some patients experienced rash (frequency uncommon), hives (urticaria; frequency rare), and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing (angioedema; frequency rare). 
Pri nekaterih bolnikih so se pojavili izpuščaj (pogostnost občasna), koprivnica (urtikarija; pogostnost redka) in otekanje obraza, ustnic, jezika in grla, kar lahko otežuje dihanje ali požiranje (angioedem; pogostnost redka).
Difference from placebo (adjusted mean) (95% CI) 
Razlika v primerjavi s placebom (prilagojena srednja vrednost) (95-odstotni IZ)
If you need to have major surgery you must stop taking Jentadueto during and for some time after the procedure. 
Če morate na večji kirurški poseg, morate v času posega in še nekaj časa po tem prenehati z jemanjem zdravila Jentadueto.
Sulphonylureas: 
Sulfonilsečnine:
D-55216 Ingelheim am Rhein, Germany. 
D-55216 Ingelheim am Rhein, Nemčija.
Jentadueto has no or negligible influence on the ability to drive and use machines. 
Zdravilo Jentadueto nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
* Based on lipase elevations >3xULN observed in clinical trials # Based on Linagliptin cardiovascular and renal safety study (CARMELINA), see also below Adverse reactions reported in patients who received metformin as monotherapy and that were not observed in patients receiving Jentadueto. 
* Na podlagi zvišanja ravni lipaze > 3 x ULN, opaženega pri kliničnih preskušanjih Na podlagi Študije o srčno-žilni in ledvični varnosti linagliptina (CARMELINA), glejte spodaj Neželeni učinki, o katerih so poročali pri bolnikih, ki so jemali metformin kot monoterapijo, in niso bili opaženi pri bolnikih, ki so jemali zdravilo Jentadueto.
Jentadueto may cause a very rare (may affect up to 1 user in 10,000), but very serious side effect called lactic acidosis (see section ‘Warnings and precautions'). 
Zdravilo Jentadueto lahko povzroči zelo redek (pojavi se lahko pri do 1 od 10.000 bolnikov), a zelo resen neželeni učinek, imenovan laktacidoza (glejte poglavje "Opozorila in previdnostni ukrepi").
Linagliptin is an inhibitor of the enzyme DPP-4 (Dipeptidyl peptidase 4) an enzyme which is involved in the inactivation of the incretin hormones GLP-1 and GIP (glucagon-like peptide-1, glucosedependent insulinotropic polypeptide). 
Linagliptin je zaviralec DPP-4 (dipeptidil-peptidaze 4), encima, ki sodeluje pri inaktivaciji dveh inkretinskih hormonov GLP-1 in GIP (glukagonu podoben peptid 1, od glukoze odvisni insulinotropni polipeptid).
Adults with normal renal function (GFR ≥90 ml/min) The dose of antihyperglycaemic therapy with Jentadueto should be individualised on the basis of the patient's current regimen, effectiveness, and tolerability, while not exceeding the maximum recommended daily dose of 5 mg linagliptin plus 2,000 mg of metformin hydrochloride. 
Odrasli z normalnim delovanjem ledvic (GFR ≥ 90 ml/min) Odmerek za antihiperglikemično zdravljenje z zdravilom Jentadueto je treba individualno prilagoditi bolnikovemu obstoječemu režimu zdravljenja, učinkovitosti in prenašanju, ne da bi prekoračili največji priporočeni dnevni odmerek, ki je 5 mg linagliptina in 2000 mg metforminijevega klorida.
Some patients have experienced inflammation of the pancreas (pancreatitis; frequency rare, may affect up to 1 in 1000 people). 
Nekateri bolniki so imeli vnetje trebušne slinavke (pankreatitis; pogostnost redka, pojavi se lahko pri največ 1 od 1.000 bolnikov).
If you forget to take Jentadueto 
Če ste pozabili vzeti zdravilo Jentadueto
Furthermore GLP-1 also reduces glucagon secretion from pancreatic alpha cells, resulting in a reduction in hepatic glucose output. 
GLP-1 poleg tega zmanjša izločanje glukagona iz celic alfa trebušne slinavke, kar zmanjša nastajanje glukoze v jetrih.
Hypoglycaemia is not identified as adverse reaction for linagliptin, metformin, or linagliptin plus metformin. 
Hipoglikemija ni opredeljena kot neželeni učinek linagliptina, metformina ali linagliptina in metformina.
Co-administration of a high-fat meal with linagliptin prolonged the time to reach Cmax by 2 hours and lowered Cmax by 15%, but no influence on AUC 0-72h was observed. 
Pri sočasnem obroku z veliko vsebnostjo maščob se je čas do dosežene Cmax podaljšal za dve uri, vrednost Cmax pa je bila za 15 % manjša, vendar vpliva na AUC0-72h niso opazili.
If you stop taking Jentadueto 
Če ste prenehali jemati zdravilo Jentadueto
Plasma concentrations of linagliptin decline in a triphasic manner with a long terminal half-life (terminal half-life for linagliptin more than 100 hours), that is mostly related to the saturable, tight binding of linagliptin to DPP-4 and does not contribute to the accumulation of the active substance. 
Plazemska koncentracija linagliptina se manjša v treh fazah in z dolgim končnim razpolovnim časom (ki za to zdravilo znaša več kot 100 ur), ki je pretežno posledica nasičene, tesne vezave linagliptina na DPP-4 in ne povečuje kopičenja zdravilne učinkovine.
Non-clinical reproduction studies did not indicate an additive teratogenic effect attributed to the coadministration of linagliptin and metformin. 
Neklinične študije o razmnoževanju ne kažejo na aditivni teratogeni učinek, ki bi ga lahko pripisali sočasnemu dajanju linagliptina in metformina.
At more than 100 times human exposure, irritation of the stomach was the major finding in these monkeys. 
Pri izpostavljenosti, ki je več kot 100-krat presegala določeno za človeka, je bil glavni izvid v teh opisih dražeč učinek v želodcu.
Caution is therefore advised, especially in patients with renal impairment, when these drugs are coadministered with metformin, as metformin plasma concentration may increase. 
Tako je priporočena previdnost pri sočasni uporabi metformina z navedenimi zdravili, še zlasti pri bolnikih z ledvično okvaro, saj lahko pride do povečanja koncentracije metformina v plazmi.
After repeated doses of 500 mg twice daily for 7 days in paediatric patients the peak plasma concentration (Cmax) and systemic exposure (AUC0-t) were reduced by approximately 33% and 40%, respectively compared to diabetic adults who received repeated doses of 500 mg twice daily for 14 days. 
Po ponovljenih odmerkih po 500 mg, ki so jih dajali dvakrat na dan 7 dni pediatričnim bolnikom, sta bili največja koncentracija v plazmi (Cmax) in sistemska izpostavljenost (AUC0-t) za približno 33 % oziroma 40 % manjši v primerjavi z vrednostmi pri odraslih bolnikih s sladkorno boleznijo, ki so prejemali ponovljene odmerke po 500 mg dvakrat na dan 14 dni.
Some patients have experienced allergic reactions (frequency rare), which may be serious, including wheezing and shortness of breath (bronchial hyperreactivity; frequency uncommon (may affect up to 1 in 100 people)). 
Nekateri bolniki so imeli alergijske reakcije (pogostnost redka), ki so lahko resne, vključno s piskanjem v pljučih in zasoplostjo (bronhialna hiperreaktivnost; pogostnost občasna (pojavi se lahko pri največ 1 od 100 bolnikov)).
No metabolites have been identified in humans. 
Pri ljudeh niso identificirali nobenih presnovkov.
Glucocorticoids (given by systemic and local routes), beta-2-agonists, and diuretics have intrinsic hyperglycaemic activity. 
Kombinacije, pri katerih je potrebna previdnost Glukokortikoidi (pri sistemski in lokalni uporabi), agonisti beta-2 in diuretiki imajo intrinzično hiperglikemično delovanje.
Mean reductions from baseline in HbA1c were generally greater for patients with higher baseline HbA1c values. 
Srednje znižanje ravni HbA1c v primerjavi z izhodiščno ravnijo je bilo večinoma večje pri bolnikih z višjo izhodiščno ravnijo HbA1c.
Absolute bioavailability of a 500 mg or 850 mg metformin hydrochloride tablet is approximately 50-60% in healthy subjects. 
Absolutna biološka uporabnost tablete po 500 mg ali 850 mg metforminijevega klorida je pri zdravih preizkušancih približno 50 do 60 %.
In addition the pharmacokinetic characteristics of linagliptin were found to be similar in dedicated phase I studies in Japanese, Chinese and Caucasian healthy subjects and African American type 2 diabetes patients. 
Poleg tega so bile farmakokinetične značilnosti linagliptina podobne tudi v namenskih študijah I. faze, ki so zajele zdrave Japonce, Kitajce in belce ter Američane afriškega izvora s sladkorno boleznijo tipa 2.
Adverse reactions reported in all clinical trials with the linagliptin+metformin combination or the use of the monocomponents (linagliptin or metformin) in clinical trials or from post-marketing experience are shown below according to system organ class. 
Neželeni učinki, o katerih so poročali v vseh kliničnih preskušanjih s kombinacijo linagliptina z metaforminom ali pri uporabi monokomponent (linagliptina ali metformina) v kliničnih preskušanjih oziroma na podlagi izkušenj po začetku trženja, so spodaj prikazani po organski sistemih.
Linagliptin concentrations in this study were within the range of values previously observed in younger type 2 diabetes patients. 
V njej so bile koncentracije linagliptina znotraj razpona vrednosti, ki so jih prej izmerili pri mlajših bolnikih s sladkorno boleznijo tipa 2.
If you take more Jentadueto tablets than you should have, you may experience lactic acidosis. 
Če ste vzeli večji odmerek zdravila Jentadueto, kot bi smeli, lahko pride do laktacidoze.
Hypoglycaemia (frequency very common (may affect more than 1 in 10 people)) is an identified side effect for the combination of Jentadueto plus sulphonylurea and for the combination Jentadueto plus insulin. 
Hipoglikemija (pogostnost: zelo pogosto (pojavi se lahko pri več kot 1 od 10 bolnikov)) je znan neželeni učinek kombinacije zdravila Jentadueto in sulfonilsečnine ter kombinacije zdravila Jentadueto in insulina.
Plasma protein binding of linagliptin is concentration-dependent, decreasing from about 99% at 1 nmol/l to 75-89% at ≥ 30 nmol/l, reflecting saturation of binding to DPP-4 with increasing concentration of linagliptin At high concentrations, where DPP-4 is fully saturated, 70-80% of linagliptin was bound to other plasma proteins than DPP-4, hence 20-30% were unbound in plasma. 
Vezava linagliptina na beljakovine v plazmi je odvisna od koncentracije in se zmanjša od približno 99 % pri 1 nmol/l na 75 do 89 % pri ≥ 30 nmol/l, kar priča o zasičenosti vezave na DPP-4 pri večanju koncentracije linagliptina.Pri velikih koncentracijah, pri katerih je DPP-4 povsem zasičen, se je 70 do 80 % linagliptina vezalo še na druge beljakovine v plazmi poleg DPP-4, zato ga je bilo 20 do 30 % nevezanega v plazmi.
The incidence of hypoglycaemia was similar across treatment groups (placebo 1.4%, linagliptin 5 mg 0%, metformin 2.1%, and linagliptin 2.5 mg plus metformin twice daily 1.4%). 
Pojavnost hipoglikemije je bila v skupinah podobna (placebo 1,4 %, linagliptin 5 mg 0 %, metformin 2,1 % in linagliptin 2,5 mg + metformin dvakrat na dan 1,4 %).
Incretins are secreted at a low basal level throughout the day and levels rise immediately after meal intake. 
Inkretini se v majhni količini izločajo ves dan, tik po jedi pa se njihova raven zviša.
Linagliptin as add-on therapy in elderly (age ≥ 70 years) with type 2 diabetes The efficacy and safety of linagliptin in elderly (age ≥ 70 years) with type 2 diabetes was evaluated in a double-blind study of 24 weeks duration. 
Linagliptin kot dodatno zdravilo pri starejših (starost ≥ 70 let) s sladkorno boleznijo tipa 2 Učinkovitost in varnost linagliptina so pri starejših (starost ≥ 70 let) s sladkorno boleznijo tipa 2 ocenili v dvojno slepi študiji, ki je trajala 24 tednov.
Strong pseudo-allergic reactions were observed in dogs at medium doses, secondarily causing cardiovascular changes, which were considered dog-specific. 
Pri psih so po dajanju srednje velikih odmerkov opazili izrazite psevdoalergijske reakcije s sekundarnimi učinki na srce in ožilje, ki so veljale za specifične pri psih.
Linagliptin glucose-dependently increases insulin secretion and lowers glucagon secretion thus resulting in an overall improvement in the glucose homeostasis. 
Linagliptin odvisno od ravni glukoze poveča izločanje insulina in zmanjša izločanje glukagona ter tako skupno izboljša homeostazo glukoze.
When Jentadueto is used with a sulphonylurea medicine or with insulin, low blood sugar can occur and your doctor may reduce the dose of your sulphonylurea or insulin. 
Pri uporabi zdravila Jentadueto hkrati s sulfonilsečnino ali insulinom pa se lahko raven krvnega sladkorja zniža na premajhno vrednost, zato lahko vaš zdravnik zmanjša odmerek sulfonilsečnine ali insulina.
The risk of developing lactic acidosis is also increased with uncontrolled diabetes, serious infections, prolonged fasting or alcohol intake, dehydration(see further information below), liver problems and any medical conditions in which a part of the body has a reduced supply of oxygen (such as acute severe heart disease). 
Tveganje za razvoj laktacidoze je večje tudi ob sočasni nenadzorovani sladkorni bolezni, resnih okužbah, dolgotrajnem postenju ali čezmernem uživanju alkohola, dehidraciji (glejte dodatne informacije spodaj), težavah z jetri ali katerih koli bolezenskih stanjih, pri katerih je oskrba dela telesa s kisikom zmanjšana (na primer akutna huda bolezen srca).
(1) reduction of hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis, (2) in muscle, by increasing insulin sensitivity, improving peripheral glucose uptake and utilisation, 
(1) z zaviranjem glukoneogeneze in glikogenolize zmanjša nastajanje glukoze v jetrih; (2) v mišicah, s povečanjem občutljivosti za insulin, izboljša periferno porabo in utilizacijo glukoze; (3) upočasni absorpcijo glukoze v črevesju.
After a median follow up of 2.2 years, linagliptin, when added to standard of care, did not increase the risk of major adverse cardiovascular events or renal outcome events. 
Po mediani spremljanja 2,2 leti, linagliptin ni povečal tveganja za hude neželene srčno-žilne dogodke ali ledvične izide, kadar je bil dodan standarni terapiji.
Avoid excessive alcohol intake while taking Jentadueto since this may increase the risk of lactic acidosis (see section ‘Warnings and precautions'). 
Med jemanjem zdravila Jentadueto ne uživajte čezmernih količin alkohola, saj lahko to poveča tveganje za laktacidozo (glejte poglavje "Opozorila in previdnostni ukrepi").
When linagliptin was added to a sulphonylurea on a background of metformin, the incidence of hypoglycaemia was increased over that of placebo. 
Če so linagliptin dodali k sulfonilsečnini ob osnovnem zdravljenju z metforminom, je bila pojavnost hipoglikemije večja kot pri placebu.
Administration of Jentadueto 2.5/1,000 mg with food resulted in no change in overall exposure of linagliptin. 
Po dajanju zdravila Jentadueto po 2.5/1.000 mg s hrano se skupna izpostavljenost linagliptinu ni spremenila.
Linagliptin in combination with metformin and insulin A 24-week placebo-controlled study was conducted to evaluate the efficacy and safety of linagliptin (5 mg once daily) added to insulin with or without metformin. 
Linagliptin v kombinaciji z metforminom in insulinom V s placebom nadzorovani 24-tedenski študiji so ocenili učinkovitost in varnost linagliptina (5 mg enkrat na dan), dodanega h insulinu z ali brez metformina.
In moderate renal impairment, a moderate increase in exposure of about 1.7 fold was observed compared with control. 
Pri zmerni ledvični okvari je bila izpostavljenost v primerjavi s kontrolo zmerno povečana, in sicer za 1,7-krat.
If this happens you must stop taking Jentadueto and contact a doctor or the nearest hospital immediately, as lactic acidosis may lead to coma. 
V tem primeru morate prenehati jemati zdravilo Jentadueto in se takoj obrniti na zdravnika ali najbližjo bolnišnico, saj lahko laktacidoza vodi v komo.
Patients treated with linagliptin exhibited a significant mean decrease from baseline in body weight compared to a significant weight gain in patients administered glimepiride (-1.39 versus +1.29 kg). 
Pri z linagliptinom zdravljenih bolnikih se je telesna masa v primerjavi z izhodiščnim stanjem pomembno zmanjšala, medtem ko se je pri bolnikih, ki so jemali glimepirid, pomembno povečala (-1,39 v primerjavi s +1,29 kg).
Bioequivalence studies in healthy subjects demonstrated that the Jentadueto (linagliptin/metformin hydrochloride) combination tablets are bioequivalent to co-administration of linagliptin and metformin hydrochloride as individual tablets. 
Bioekvivalenčne študije pri zdravih prostovoljcih so pokazale, da je kombinirano zdravilo Jentadueto (linagliptin/metforminijev klorid) bioekvivalentno sočasno danim posamičnim tabletam linagliptina in metforminijevega klorida.
Glycaemic parameters at final visit (24-week study) for linagliptin and metformin, alone and in combination in patients with type 2 diabetes mellitus inadequately controlled on diet and exercise 
Glikemični parametri na zadnjem obisku (24-tedenska študija) za linagliptin in metformin pri samostojni uporabi in kombinaciji pri bolnikih s sladkorno boleznijo tipa 2 in neustrezno urejeno boleznijo z dieto in telesno aktivnostjo
If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before taking Jentadueto. 
Če ste v dvomih o tem, ali kaj od naštetega velja za vas, se pogovorite s svojim zdravnikom, farmacevtom ali z medicinsko sestro, preden boste vzeli zdravilo Jentadueto.
PHARMACEUTICAL FORM AND CONTENTS 60 x 1 film-coated tablets. 
FARMACEVTSKA OBLIKA IN VSEBINA 60 x 1 filmsko obložena tableta.
One main metabolite with a relative exposure of 13.3% of linagliptin at steady-state was detected which was found to be pharmacologically inactive, and thus does not contribute to the plasma DPP-4 inhibitory activity of linagliptin. 
V stanju dinamičnega ravnovesja so odkrili en glavni presnovek, pri katerem je bila relativna izpostavljenost linagliptinu 13,3 %, ki pa je bil farmakološko neaktiven in ni povečeval zaviralnega delovanja linagliptina na DPP-4 v plazmi.
In rats, effects on reproductive organs, thyroid and the lymphoid organs were seen at more than 1500 times human exposure. 
Pri podganah so odkrili učinke na reproduktivne organe, ščitnico in limfne organe pri izpostavljenosti, ki je bila preko 1.500-krat večja od izpostavljenosti pri človeku.
Lactic acidosis is characterised by acidotic dyspnea, abdominal pain, muscle cramps, asthenia and hypothermia followed by coma. 
Za laktacidozo so značilni acidozna dispneja, bolečina v trebuhu, mišični krči, astenija in hipotermija, ki ji sledi koma.
The mean HbA1c at baseline was 7.15%. 
Povprečna izhodiščna vrednost HbA1c je bila 7,15 %.
For the entire treatment period (median time on treatment 5.9 years) the rate of patients with moderate or severe hypoglycaemia was 6.5% on linagliptin versus 30.9% on glimepiride, severe hypoglycaemia occurred in 0.3% of patients on linagliptin versus 2.2% on glimepiride. 
V celotnem obdobju zdravljenja (mediani čas zdravljenja 5,9 let) je imelo zmerno ali hudo hipoglikemijo 6,5 % bolnikov, ki so jemali linagliptin, in 30,9 % bolnikov, ki so jemali glimepiridin, huda hipoglikemija se je pojavila pri 0,3 % bolnikov, ki so jemali linagliptin, in 2,2 % bolnikov, ki so jemali glimepiridin.
After once daily dosing of 5 mg linagliptin, steady-state plasma concentrations are reached by the third dose. 
Pri dajanju po 5 mg linagliptina enkrat na dan je stanje dinamičnega ravnovesja koncentracije v plazmi doseženo do tretjega odmerka.
A statistically significant greater proportion of patients with a baseline HbA1c ≥7.0% and treated with linagliptin 5 mg achieved a target HbA1c of <7% compared to placebo. 
Statistično pomembno večji delež bolnikov, zdravljenih z linagliptinom 5 mg in izhodiščno vrednostjo HbA1c ≥ 7,0 %, je v primerjavi s placebom, dosegel ciljno vrednost HbA1c < 7,0 %.
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity to reproduction and development. 
Podatki, ki niso pridobljeni v kliničnih raziskavah na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih odmerkih, genotoksičnosti, kancerogenega potenciala, vpliva na sposobnost razmnoževanja in razvoja ne kažejo posebnega tveganja za človeka.
After oral administration of a 5 mg dose to healthy volunteers or patients, linagliptin was rapidly absorbed, with peak plasma concentrations (median Tmax) occurring 1.5 hours post-dose. 
Po peroralnem dajanju odmerka po 5 mg se je linagliptin pri zdravih prostovoljcih ali bolnikih hitro absorbiral in dosegel največjo plazemsko koncentracijo (mediana Tmax) 1,5 ure po odmerku.
Adverse reactions reported in patients who received linagliptin+metformin alone (as mono-components or in combination) or as add-on to other anti-diabetic therapies in clinical trial and from post-marketing experience 
Neželeni učinki, o katerih so poročali pri bolnikih, ki so prejemali linagliptin in metformin (kot monokomponento ali v kombinaciji) kot samostojno zdravljenje ali kot dodatek drugim zdravljenjem z antidiabetiki pri kliničnem preskušanju in iz izkušenj po začetku trženja
Discontinuation of therapy due to adverse events was comparable in patients who received placebo and metformin to patients treated with linagliptin and metformin (3.8% and 2.9%). 
Pogostnost prekininjenih zdravljenj zaradi neželenih dogodkov je bila pri bolnikih, ki so jemali placebo in metformin, primerljiva s pogostnostjo pri tistih, ki so jemali linagliptin in metformin (3,8 % in 2,9 %).
In placebocontrolled studies, more than 1800 patients were treated with the therapeutic dose of either 2.5 mg linagliptin twice daily (or its bioequivalent of 5 mg linagliptin once daily) in combination with metformin for ≥ 12/24 weeks. 
V s placebom nadzorovanih študijah se je več kot 1800 bolnikov zdravilo s terapevtskimi odmerki po 2,5 mg linagliptina dvakrat na dan (ali z bioekvivalenti po 5 mg linagliptina enkrat na dan) v kombinaciji z metforminom ≥ 12/24 tednov.
Studies in animals have shown excretion of both metformin and linagliptin into milk in lactating rats. 
Študije na živalih so pokazale, da se pri podganah v laktaciji metformin in linagliptin izločata v mleko.
Multiple daily doses of linagliptin had a minimal effect on the steady-state pharmacokinetics of simvastatin, a sensitive CYP3A4 substrate, in healthy subjects. 
Linagliptin je pri dajanju večkratnih dnevnih odmerkov pri zdravih prostovoljcih le minimalno vplival na farmakokinetiko simvastatina, občutljivega substrata za CYP3A4, v stanju dinamičnega ravnovesja.
In addition, linagliptin is not expected to be eliminated to a therapeutically significant degree by hemodialysis or peritoneal dialysis. 
Poleg tega obseg izločanja linagliptina med hemodializo ali peritonealno dializo predvidoma ni terapevtsko pomemben.
Jentadueto is indicated in adults with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control: 
Zdravilo Jentuado je indicirano za zdravljenje odraslih bolnikov s sladkorno boleznijo tipa 2 kot dodatek k dieti in telesni aktivnosti za izboljšanje urejenosti glikemije:
Multiple daily doses of 5 mg linagliptin did not alter the pharmacokinetics of S(-) or R(+) warfarin, a CYP2C9 substrate, administered in a single dose. 
Pri dajanju večkratnih dnevnih odmerkov linagliptina po 5 mg se farmakokinetika varfarina S(-) ali R(+), substrata za CYP2C9, po enkratnem odmerku ni spremenila.
Bottles contain 14, 60 or 180 film-coated tablets. 
Plastenke vsebujejo 14, 60 ali 180 filmsko obloženih tablet.