natgillin/translations-raw huggingface dataset:
In a double blind multicenter, parallel group study, enoxaparin sodium 2,000 IU (20 mg) or 4,000 IU (40 mg) once a day SC was compared to placebo in the prophylaxis of DVT in medical patients with severely restricted mobility during acute illness (defined as walking distance of <10 meters for ≤3 days). 
V dvojno slepi, multicentrični študiji vzporednih skupin so natrijev enoksaparinat v odmerkih 2.000 i.e. (20 mg) ali 4.000 i.e. (40 mg) enkrat na dan subkutano primerjali s placebom za profilakso GVT pri nekirurških bolnikih z zelo omejeno mobilnostjo med akutno boleznijo (opredeljeno kot prehojena razdalja < 10 metrov ≤ 3 dni).
Injection site nodules* (inflammatory nodules, which were not cystic enclosure of enoxaparin). 
• Vozliči* na mestu injiciranja (vnetni vozliči, ki niso bili cistični skupki enoksaparina).
Spinal/epidural anaesthesia or lumbar puncture must not be performed within 24 hours of administration of enoxaparin sodium at therapeutic doses (see also section 4.3). 
Spinalne/epiduralne anestezije ali lumbalne punkcije se ne sme opraviti v 24 urah po uporabi terapevtskih odmerkov natrijevega enoksaparinata (glejte poglavje 4.3).
• History of immune mediated heparin-induced thrombocytopenia (HIT) within the past 100 days or in the presence of circulating antibodies (see also section 4.4 ); 
• Anamnezo imunske, s heparinom izzvane trombocitopenije (HIT) v zadnjih 100 dneh ali prisotnost protiteles v obtoku (glejte tudi poglavje 4.4).
After 12 hours of the enoxaparin sodium injection, protamine administration may not be required. 
Če je od injiciranja natrijevega enoksaparinata minilo več kot 12 ur, utegne biti uporaba protamina nepotrebna.
This is by injection into your vein. 
Dobili ga boste z injekcijo v veno.
• For the prevention of thrombus formation in the extra corporeal circulation during haemodialysis, it is administered through the arterial line of a dialysis circuit. 
• Za preprečevanje nastanka strdkov v zunajtelesnem obtoku med hemodializo se daje skozi arterijsko linijo v dializni obtok.
For the prophylaxis of venous thrombo-embolic disease following surgery, treatment of DVT and PE, treatment of unstable angina and NSTEMI, enoxaparin sodium should be administered by SC injection. 
Za profilakso venske trombembolične bolezni po operaciji, za zdravljenje GVT in PE ter za zdravljenje nestabilne angine pektoris in NSTEMI je treba natrijev enoksaparinat injicirati subkutano.
• Stop blood clots forming in the tubes of your dialysis machine (used for people with severe kidney problems). 
Preprečitev nastajanja krvnih strdkov v cevkah dializne naprave (uporablja se pri osebah, ki imajo hude težave z ledvicami).
• Other medicinal products affecting haemostasis such as: - Platelet aggregation inhibitors including acetylsalicylic acid used at antiaggregant dose (cardioprotection), clopidogrel, ticlopidine, and glycoprotein IIb/IIIa antagonists indicated in acute coronary syndrome due to the risk of bleeding, - Dextran 40, - Systemic glucocorticoids. 
• Druga zdravila, ki vplivajo na hemostazo, na primer: - zaviralci agregacije trombocitov, vključno z acetilsalicilno kislino v antiagregacijskih odmerkih (zaščita srca), klopidogrel, tiklopidin in antagonisti glikoproteina IIb/IIIa, ki so indicirani pri akutnem koronarnem sindromu, zaradi tveganja za krvavitve,
• If you have any sign of blockage of a blood vessel by a blood clot such as: - cramping pain, redness, warmth, or swelling in one of your legs - these are symptoms of deep vein thrombosis - breathlessness, chest pain, fainting or coughing up blood - these are symptoms of a pulmonary embolism 
• Če imate kakršen koli znak zamašitve žile s krvnim strdkom, na primer: - krčevite bolečine, pordelost, toploto ali oteklost ene noge - to so simptomi globoke venske
Enoxaparin sodium has no or negligible influence on the ability to drive and use machines. 
Natrijev enoksaparinat nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
Nervous system disorders • Common: Headache* 
Bolezni živčevja • Pogosti: Glavobol*
Therefore, for patients on enoxaparin sodium, the PCI was to be performed on enoxaparin sodium (no switch) using the regimen established in previous studies i.e. no additional dosing, if last SC administration given less than 8 hours before balloon inflation, IV bolus of 30 IU/ kg (0.3 mg/kg) enoxaparin sodium, if the last SC administration given more than 8 hours before balloon inflation. 
Zato je morala biti za bolnike na natrijevem enoksaparinatu PKI narejena na natrijevem enoksaparinatu (brez menjave) in po shemi, oblikovani v predhodnih študijah - tj. brez dodatnega odmerjanja, če je bila zadnja subkutana uporaba manj kot 8 ur pred balonskim širjenjem, in intravenski bolus 30 i.e./kg (0,3 mg/kg) natrijevega enoksaparinata, če je bila zadnja subkutana uporaba več kot 8 ur pred balonskim širjenjem.
A 3,000 IU (30 mg) IV bolus immediately followed by a 100 IU/kg (1 mg/kg) SC every 12 hours provided initial maximum anti-Xa activity level of 1.16 IU/mL (n=16) and average exposure corresponding to 88% of steady-state levels. 
Intravenski bolus 3.000 i.e. (30 mg), ki mu je takoj sledila subkutana uporaba 100 i.e./kg (1 mg/kg) na 12 ur, je dosegel uvodno največjo raven aktivnosti anti-Xa 1,16 i.e./ml (n = 16) in povprečno izpostavljenost, ki je ustrezala 88 % tiste v stanju dinamičnega ravnovesja.
After repeated SC administration of 4,000 IU (40 mg) once daily and 150 IU/kg (1.5 mg/kg) once daily regimens in healthy volunteers, the steady-state is reached on day 2 with an average exposure ratio about 15% higher than after a single dose. 
Po ponavljajoči se subkutani uporabi 4.000 i.e. (40 mg) enkrat na dan in 150 i.e./kg (1,5 mg/kg) enkrat na dan pri zdravih prostovoljcih je stanje dinamičnega ravnovesja doseženo 2. dan, povprečno razmerje izpostavljenosti pa je približno 15 % večje kot po enkratnem odmerku.
The following medicinal products may be administered with caution concomitantly with enoxaparin sodium: 
Sočasna uporaba, ki zahteva previdnost: Naslednja zdravila se lahko previdno uporabijo sočasno z natrijevim enoksaparinatom:
• The usual dose is 75 IU (0.75 mg) for every kilogram of your weight, every 12 hours. 
• Običajen odmerek je 75 i.e. (0,75 mg) na kilogram telesne mase na 12 ur.
Enoxaparin sodium has shown no mutagenic activity based on in vitro tests, including the Ames test, mouse lymphoma cell forward mutation test, and no clastogenic activity based on an in vitro human lymphocyte chromosomal aberration test, and the in vivo rat bone marrow chromosomal aberration test. 
Natrijev enoksaparinat v testiranjih in vitro (vključno z Amesovim testom in testom naprednih mutacij na mišjih limfomskih celicah) ni pokazal mutagenosti; prav tako na podlagi in vitro testa kromosomskih aberacij človeških limfocitov ter in vitro testa kromosomskih aberacij na podganjem kostnem mozgu ni pokazal klastogenosti.
Enoxaparin sodium may be safely administered with normal saline solution (0.9%) or 5% dextrose in water. 
Natrijev enoksaparinat lahko varno daste s fiziološko raztopino (0,9 % raztopino natrijevega klorida) ali 5 % glukozo v vodi.
Enoxaparin sodium should be used with caution in patients with hepatic impairment due to an increased potential for bleeding. 
Natrijev enoksaparinat je treba pri bolnikih z okvaro jeter uporabljati previdno, ker imajo večjo možnost za krvavitve.
It is advised that the trade name and batch number of the product you are using are recorded by your healthcare professional. 
Priporočljivo je, da zdravnik zabeleži ime in številko serije zdravila, ki ga uporabljate.
- Changing from treatment with direct oral anticoagulant to Thorinane Stop taking direct oral anticoagulant. 
- Prehod z zdravljenja z neposrednim peroralnim antikoagulansom na zdravilo Thorinane Nehajte jemati neposredni peroralni antikoagulans.
Each mL contains 100 mg enoxaparin sodium. 
En ml vsebuje 100 mg natrijevega enoksaparinata.
• Common: Haemorrhage, haemorrhagic anaemia*, thrombocytopenia, thrombocytosis 
• Pogosti: Krvavitev, hemoragična anemija*, trombocitopenija, trombocitoza
What Thorinane contains - The active substance is enoxaparin sodium. 
Kaj vsebuje zdravilo Thorinane - Zdravilna učinkovina je natrijev enoksaparinat.
• Treat blood clots that are in your blood 
• Zdravljenje krvnih strdkov v vaši krvi
• Uncommon: Hepatocellular liver injury * 
• Občasni: Hepatocelularna okvara jeter*
Detailed information is available on the website of the European Medicines Agency http://www.ema.europa.eu. 
Podrobne informacije so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu
Although no dose adjustment is recommended in patients with moderate (creatinine clearance 3050 mL/min) and mild (creatinine clearance 50-80 mL/min) renal impairment, careful clinical monitoring is advised. 
Čeprav pri bolnikih z zmerno (očistek kreatinina 30-50 ml/min) ali blago (očistek kreatinina 50-80 ml/min) okvaro ledvic odmerka ni treba prilagoditi, je priporočljivo natančno klinično spremljanje.
For all indications except STEMI, no dose reduction is necessary in the elderly patients, unless kidney function is impaired (see below “renal impairment” and section 4.4). 
Starejšim bolnikom odmerka ni treba zmanjšati za nobeno indikacijo razen za STEMI; izjema so bolniki, ki imajo okvarjeno delovanje ledvic (glejte spodaj "Okvara ledvic" in poglavje 4.4).
4) Carefully pull off the needle cap from the syringe. 
4) Z brizge previdno snemite pokrovček igle.
To obtain a 300 IU/mL (3 mg/mL) solution, using a 6,000 IU (60 mg) enoxaparin sodium pre-filled syringe, it is recommended to use a 50 mL infusion bag (i.e. using either normal saline solution (0.9%) or 5% dextrose in water) as follows: 
Za pripravo raztopine 300 i.e./ml (3 mg/ml) z uporabo napolnjene injekcijske brizge s 6.000 i.e. (60 mg) natrijevega enoksaparinata je priporočljivo uporabiti 50-ml infuzijsko vrečko (tj. z uporabo fiziološke raztopine (0,9 % raztopine natrijevega klorida) ali 5 % raztopine glukoze v vodi) takole: Iz infuzijske vrečke z brizgo odvzemite 30 ml in to tekočino zavrzite.
In patients with severe renal impairment (creatinine clearance 15-30 mL/min), since exposure of enoxaparin sodium is significantly increased, a dosage adjustment is recommended for therapeutic and prophylactic dosage ranges (see section 4.2). 
Ker so bolniki s hudo okvaro ledvic (očistek kreatinina < 15-30 ml/min) pomembno bolj izpostavljeni natrijevemu enoksaparinatu, jim je priporočljivo prilagoditi terapevtske in profilaktične odmerke (glejte poglavje 4.2).
Patients had to be treated in hospital for a minimum of 2 days and a maximum of 8 days, until clinical stabilization, revascularization procedures or hospital discharge. 
V obeh skupinah so bolniki prejemali tudi 100 do 325 mg acetilsalicilne kisline enkrat na dan. Bolniki so se morali zdraviti v bolnišnici najmanj 2 dni in največ 8 dni, dokler se klinično stanje ni stabiliziralo, ni bila izvedena revaskularizacija ali bolnik ni bil odpuščen iz bolnišnice.
Enoxaparin sodium pharmacokinetics appeared similar than control population, after a single 25 IU, 50 IU or 100 IU/kg (0.25, 0.50 or 1.0 mg/kg) IV dose however, AUC was two-fold higher than control. 
Farmakokinetika natrijevega enoksaparinata je bila po enkratnih intravenskih odmerkih 25 i.e., 50 i.e. ali 100 i.e./kg (0,25, 0,50 ali 1,0 mg/kg) podobna kot v kontrolni populaciji, toda AUC je bila dvakrat večja kot v kontrolni populaciji.
For patients with creatinine clearance [15-30 mL/minute], additional considerations are necessary because elimination of enoxaparin sodium is more prolonged (see section 4.2). 
Pri bolnikih z očistkom kreatinina od 15 do 30 ml/min je potreben dodaten preudarek, ker je odstranjevanje natrijevega enoksaparinata dolgotrajnejše (glejte poglavje 4.2).
Prevention of venous thromboembolic disease associated with surgery 
Preprečevanje venske tromboembolične bolezni, povezane z operacijami
Your doctor may request you perform a blood test to check your platelet count. 
Zdravnik vas lahko pošlje na preiskavo krvi za kontrolo števila trombocitov.
• Your doctor or nurse will normally give you Thorinane. 
• Običajno vam bo zdravilo Thorinane dal zdravnik ali medicinska sestra.
In a study conducted in patients with advanced cirrhosis treated with enoxaparin sodium 4,000 IU (40 mg) once daily, a decrease in maximum anti-Xa activity was associated with an increase in the severity of hepatic impairment (assessed by Child-Pugh categories). 
V raziskavi bolnikov z napredovalo cirozo, zdravljenih s 4.000 i.e. (40 mg) natrijevega enoksaparinata enkrat na dan, je bila hujša okvara jeter (ocenjena s kategorijami po Child-Pughu) povezana z zmanjšanjem največje aktivnosti anti-Xa.
Inject the complete contents of the 6,000 IU (60 mg) enoxaparin sodium pre-filled syringe into the 20 mL remaining in the bag. 
Injicirajte celotno vsebino napolnjene injekcijske brizge s 6.000 i.e. (60 mg) natrijevega enoksaparinata v 20 ml, ki so preostali v vrečki.
When used as prophylactic treatment, enoxaparin sodium does not significantly affect the aPTT. 
Če je natrijev enoksaparinat uporabljen za profilaktično zdravljenje, nima pomembnega vpliva na aPTČ.
• you have endocarditis (an infection of the inner lining of the heart) 
• če imate endokarditis (okužbo notranje plasti srčne stene) • če ste kdaj imeli razjedo na želodcu
After repeated SC 150 IU/kg (1.5 mg/kg) once daily dosing, mean AUC of anti-Xa activity is marginally higher at steady state in obese healthy volunteers (BMI 30-48 kg/m2) compared to non-obese control subjects, while maximum plasma anti-Xa activity level is not increased. 
Po večkratni subkutani uporabi 150 i.e./kg (1,5 mg/kg) enkrat na dan je povprečna AUC aktivnosti antiXa v stanju dinamičnega ravnovesja pri debelih zdravih prostovoljcih (ITM 30-48 kg/m2) malenkostno večja kot pri nedebelih kontrolnih osebah, največja raven aktivnosti anti-Xa v plazmi pa ni povečana.
• The usual dose is 150 IU (1.5 mg) for every kilogram of your weight each day or 100 IU (1 mg) for every kilogram of your weight twice a day. 
• Običajen odmerek je 150 i.e. (1,5 mg) na kilogram telesne mase na dan ali 100 i.e. (1 mg) na kilogram telesne mase dvakrat na dan.
Use of enoxaparin sodium in patients with a history of immune mediated HIT within the past 100 days or in the presence of circulating antibodies is contraindicated (see section 4.3). 
Uporaba natrijevega enoksaparinata je kontraindicirana pri bolnikih, ki imajo v anamnezi imunsko HIT v zadnjih 100 dneh, ali imajo protitelesa v obtoku (glejte poglavje 4.3).
For acute STEMI, treatment is to be initiated with a single IV bolus injection immediately followed by a SC injection. 
• Zdravljenje akutnega STEMI je treba začeti z eno intravensko bolusno injekcijo, ki ji neposredno sledi subkutana injekcija.
Major bleeding were respectively 1.7% in the enoxaparin sodium 150 IU/kg (1.5 mg/kg) once a day group, 1.3% in the enoxaparin sodium 100 IU/kg (1 mg/kg) twice a day group and 2.1% in the heparin group. 
Večjih krvavitev je bilo v skupini s 150 i.e./kg (1,5 mg/kg) natrijevega enoksaparinata enkrat na dan 1,7 %, v skupini s 100 i.e./kg (1 mg/kg) natrijevega enoksaparinata dvakrat na dan 1,3 % in v skupini s heparinom 2,1 %.
Enoxaparin sodium is administered by deep SC injection. 
Natrijev enoksaparinat se daje z globoko subkutano injekcijo.
Patients receiving the twice daily doses (i.e. 75 IU/kg (0.75 mg/kg) twice daily or 100 IU/kg (1 mg/kg) twice-daily) should omit the second enoxaparin sodium dose to allow a sufficient delay 
Bolniki, ki prejemajo odmerke dvakrat na dan (tj. 75 i.e./kg (0,75 mg/kg) dvakrat na dan ali 100 i.e./kg (1 mg/kg) dvakrat na dan), morajo izpustiti drugi odmerek natrijevega enoksaparinata, da se zagotovi zadosten presledek med namestitvijo ali odstranitvijo katetra.
Depending on when you were last given Thorinane, your doctor may decide to give an additional dose of Thorinane before a PCI operation. 
Pri bolnikih, ki so jim opravili poseg, imenovan perkutana koronarna intervencija (PKI): Odvisno od tega, kdaj ste nazadnje dobili zdravilo Thorinane, se zdravnik lahko odloči za dodaten odmerek zdravila Thorinane pred PKI.
The Thorinane pre-filled syringes are for single dose use only. 
Napolnjene injekcijske brizge zdravila Thorinane vsebujejo en sam odmerek.
- The pre-filled syringe is intended for single use only. 
- Napolnjena injekcijska brizga je samo za enkratno uporabo.
If the last SC administration was given more than 8 hours before balloon inflation, an IV bolus of 30 IU/kg (0.3 mg/kg) enoxaparin sodium should be administered. 
Če je bil zadnji subkutani odmerek uporabljen več kot 8 ur pred balonskim širjenjem, je treba dati intravenski bolus 30 i.e./kg (0,3 mg/kg) natrijevega
The rate of the 30 day composite endpoint of death, myocardial re-infarction or intracranial haemorrhage (a measure of net clinical benefit) was significantly lower (p<0.0001) in the enoxaparin sodium group (10.1%) as compared to the heparin group (12.2%), representing a 17% relative risk reduction in favour of treatment with enoxaparin sodium. 
Delež sestavljenega opazovanega dogodka smrti, ponovnega miokardnega infarkta ali intrakranialne krvavitve (mera neto klinične koristi) v 30 dneh je bil v skupini z natrijevim enoksaparinatom značilno manjši (10,1 %) kot v skupini s heparinom (12,2 %) (p < 0,0001), kar pomeni 17 % relativno zmanjšanje tveganja v korist zdravljenja z natrijevim enoksaparinatom.
The incidence of major bleeding at 30 days was significantly higher (p<0.0001) in the enoxaparin sodium group (2.1%) versus the heparin group (1.4%). 
Incidenca večjih krvavitev je bila po 30 dneh v skupini z natrijevim enoksaparinatom značilno večja (2,1 %, p < 0,0001) kot v skupini s heparinom (1,4 %).
How to give yourself an injection of Thorinane 
Kako si sami injicirate zdravilo Thorinane
Thorinane contains the active substance called enoxaparin sodium that is a low molecular weight heparin (LMWH). 
Zdravilo Thorinane vsebuje zdravilno učinkovino natrijev enoksaparinat, ki je nizkomolekularni heparin (NMH).
For patients with creatinine clearance [15-30] mL/min, consider doubling the timing of puncture/catheter placement or removal to at least 48 hours. 
Pri bolnikih z očistkom kreatinina od 15 do 30 ml/min pride v poštev podvojitev časa do punkcije/namestitve ali odstranitve katetra na vsaj 48 ur.
Do not rub the injection site after administration. 
Mesta injiciranja po injiciranju ne drgnite.
2) Stopping blood clots from forming in your blood. 
2) Preprečuje nastanek krvnih strdkov v krvi.
At doses used for prophylaxis of venous thromboembolism, enoxaparin sodium does not influence bleeding time and global blood coagulation tests significantly, nor does it affect platelet aggregation or binding of fibrinogen to platelets. 
V odmerkih, uporabljanih za profilakso venske trombembolije, natrijev enoksaparinat ne vpliva pomembno na čas krvavitve in preiskave celotne koagulacije krvi.
After dilution the solution should be used within 8 hours. 
Raztopino po redčenju porabite v 8 urah.
Enoxaparin sodium is a low clearance drug with a mean anti-Xa plasma clearance of 0.74 L/h after a 150 IU /kg (1.5 mg/kg) 6-hour IV infusion. 
Natrijev enoksaparinat je zdravilo z majhnim očistkom; povprečni očistek anti-Xa iz plazme po 6-urni intravenski infuziji 150 i.e./kg (1,5 mg/kg) je 0,74 l/h.
• In patients at moderate risk of thromboembolism, the recommended dose of enoxaparin sodium is 2,000 IU (20 mg) once daily by subcutaneous (SC) injection. 
• Za bolnike z zmernim tveganjem za trombembolijo je priporočeni odmerek natrijevega enoksaparinata 2.000 i.e. (20 mg) enkrat na dan v subkutani injekciji.
• For treatment of unstable angina and NSTEMI, the recommended dose of enoxaparin sodium is 100 IU/kg (1 mg/kg) every 12 hours by SC injection administered in combination with antiplatelet therapy. 
• Za zdravljenje nestabilne angine pektoris in NSTEMI je priporočeni odmerek natrijevega enoksaparinata 100 i.e./kg (1 mg/kg) na 12 ur v subkutani injekciji, dani v kombinaciji z antiagregacijskim zdravljenjem.
Method of administration Thorinane should not be administered by the intramuscular route. 
Način uporabe Zdravila Thorinane se ne sme injicirati intramuskularno.
For the initial 3,000 IU (30 mg) bolus, using an enoxaparin sodium graduated pre-filled syringe, expel the excessive volume to retain only 3,000 IU (30 mg) in the syringe. 
Za injiciranje začetnega bolusa 3.000 i.e. (30 mg) natrijevega enoksaparinata z graduirano napolnjeno injekcijsko brizgo iztisnite odvečno količino, tako da bo v brizgi ostalo le 3.000 i.e. (30 mg).
However, since renal function is known to decline with age, elderly patients may show reduced elimination of enoxaparin sodium (see sections 4.2 and 4.4). 
Ker pa je znano, da se delovanje ledvic s starostjo zmanjšuje, je odstranjevanje natrijevega enoksaparinata pri starejših bolnikih lahko upočasnjeno (glejte poglavji 4.2 in 4.4).
Volume to inject when diluted to a final concentration of 300 IU (3 mg) / mL 
Količina, ki jo je treba injicirati, če je razredčenje opravljeno na končno koncentracijo 300 i.e. (3 mg) / ml
For patients with creatinine clearance [15-30] mL/min, consider doubling the timing of puncture/catheter placement or removal to at least 24 hours. 
Pri bolnikih z očistkom kreatinina od 15 do 30 ml/min pride v poštev podvojitev časa do punkcije/namestitve ali odstranitve katetra na vsaj 24 ur.
Enoxaparin sodium prophylaxis for four weeks after surgery for abdominal or pelvic cancer significantly reduced the incidence of venographically demonstrated thrombosis, as compared with enoxaparin sodium prophylaxis for one week. 
Štiritedenska profilaksa z natrijevim enoksaparinatom po operaciji raka v trebuhu ali medeničnem predelu je v primerjav z enotedensko profilakso z natrijevim enoksaparinatom značilno zmanjšala incidenco venografsko dokazane tromboze.
Talk to your doctor or pharmacist before using Thorinane if: 
Pred uporabo zdravila Thorinane se posvetujte z zdravnikom ali farmacevtom:
• Stop blood clots from forming in your blood in the following situations: o When you have an acute illness and face period of limited mobility o When you have unstable angina (a condition when not enough blood gets to your heart) 
o Če imate akutno bolezen in vas čaka obdobje omejene možnosti gibanja (mobilnosti) o Če imate nestabilno angino pektoris (motnjo, pri kateri v srce ne pride dovolj krvi)
At approximately 3 months following enrolment, the incidence of VTE remained significantly lower in the enoxaparin sodium 4,000 IU (40 mg) treatment group versus the placebo treatment group. 
Približno 3 mesece po vključitvi je ostala incidenca VTE v terapevtski skupini s 4.000 i.e. (40 mg) natrijevega enoksaparinata značilno manjša kot v skupini s placebom.
An increase in exposure of enoxaparin sodium with prophylactic dosages (non-weight adjusted) has been observed in low-weight women (<45 kg) and low-weight men (<57 kg), which may lead to a higher risk of bleeding. 
Pri bolnikih z majhno telesno maso (ženskah < 45 kg in moških < 57 kg) so med profilaktičnim odmerjanjem (neprilagojenim za telesno maso) opažali večjo izpostavljenost natrijevemu enoksaparinatu; to lahko poveča tveganje za krvavitve.
The dose of protamine depends on the dose of enoxaparin sodium injected; 1 mg protamine neutralizes the anticoagulant effect of 100 IU (1 mg) of enoxaparin sodium, if enoxaparin sodium was administered in the previous 8 hours. 
Odmerek protamina je odvisen od odmerka injiciranega natrijevega enoksaparinata; če je bil natrijev enoksaparinat apliciran v zadnjih 8 urah, 1 mg protamina nevtralizira antikoagulantni učinek 100 i.e./kg (1 mg) natrijevega enoksaparinata.
To avoid the possible mixture of enoxaparin sodium with other drugs, the IV access chosen should be flushed with a sufficient amount of saline or dextrose solution prior to and following the IV bolus administration of enoxaparin sodium to clear the port of drug. 
Da boste preprečili možno mešanje natrijevega enoksaparinata z drugimi zdravili, morate intravenski dostop sprati z zadostno količino fiziološke raztopine ali raztopine glukoze, in sicer pred dajanjem intravenskega bolusa natrijevega enoksaparinata in po njem, da boste nastavek očistili zdravila.