natgillin/translations-raw huggingface dataset:
The requirements for submission of PSURs for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal. 
(seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES, in vseh kasnejših posodobitvah, objavljenih na evropskem spletnem portalu o zdravilih.
Spherox is an autologous medicinal product and must not be given to any other patient than the donor. 
Zdravilo Spherox je avtologno zdravilo in se ne sme dajati nobenemu drugemu bolniku razen darovalcu.
Physical activity should be resumed as recommended by the physician. 
S telesno dejavnostjo mora bolnik začeti tako, kot priporoča zdravnik.
The spheroids self-adhere within 20 minutes onto the defect ground. 
Sferoidi se po 20 minutah samodejno prilepijo na površino poškodbe.
• pain of the front knee or kneecap 
• bolečina sprednjega dela kolena ali pogačice;
Cartilage tissue is present in every joint as a hard smooth layer on the surface of bone ends. 
Hrustančno tkivo je prisotno v vsakem sklepu kot trda gladka plast na površini konca kosti.
If Spherox is appropriate for you, the doctor takes a small cartilage sample from your joint. 
Če je zdravilo Spherox za vas primerno, zdravnik odvzame majhen vzorec hrustanca iz vašega sklepa.
Any unused product or waste material should be disposed in accordance with local requirements. 
Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
Afterwards, the surgical wound can be closed without any additional cover of the treated area (e.g. periosteal flap), or any fixation of spheroids by using fibrin glue. 
Potem je mogoče kirurško rano zapreti brez dodatnega pokrivanja zdravljenega območja (npr. periostalnega režnja) in brez kakršnega koli fiksiranja sferoidov s fibrinskim lepilom.
4.5 Interaction with other medicinal products and other forms of interaction 
4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Študij medsebojnega delovanja niso izvedli.
For intraarticular use. 
Za intraartikularno uporabo
No signs of inflammation, synovitis, infections, rejection, hypertrophy or immune toxicity, tumourigenicity or biodistribution were observed. 
Opaženih ni bilo nobenih znakov vnetja, sinovitisa, okužb, zavrnitve, hipertrofije ali imunske toksičnosti ter tumorogenosti ali biološke porazdelitve.
The applicator is delivered with an application device (sterile injection syringe). 
Aplikator je dobavljen z napravo za aplikacijo (sterilno injekcijsko brizgo).
• you are infected with HIV (the virus that causes AIDS), hepatitits B virus or with hepatitis C 
• če ste okuženi z virusom HIV (virusom, ki povzroča AIDS), virusom hepatitisa B ali virusom hepatitisa C.
The treatment of defect sizes up to 10 cm2 is eligible for single as well as adjacent defects (combined area). 
Zdravljenje poškodb velikosti do 10 cm2 je upravičeno za posamične in sosednje poškodbe (združeno območje).
The marketing authorisation holder (MAH) shall submit the first PSUR for this product within 6 months following authorisation. 
Imetnik dovoljenja za promet z zdravilom mora prvo PSUR za to zdravilo predložiti v 6 mesecih po pridobitvi dovoljenja za promet.
Mainly, patients were treated with cartilage defects in knee. 
Večinoma so bili zdravljeni bolniki s poškodbami hrustanca v kolenu.
Name and address of the manufacturer of the biological active substance 
Ime in naslov izdelovalca biološke učinkovine
This is usually done as keyhole surgery through very small incisions (cuts), using a special instrument to look inside the knee (arthroscopy). 
To je običajno opravljeno z endoskopsko operacijo, ki poteka prek zelo majhnih incizij (rezov) s posebnim instrumentom za pogled v notranjost kolena (z artroskopijo).
Visit 1: Evaluation of the cartilage defect, sample and blood taking 
Prvi obisk: ocena poškodbe hrustanca, odvzem vzorca in krvi
Follow the rehabilitation program, strictly, after implantation. 
Rehabilitacijski program Po vsaditvi strogo upoštevajte rehabilitacijski program.
Further patient scores, e.g. the International Knee Documentation Committee (IKDC; subjective evaluation of the knee) and the Lysholm score showed after 12, 24, 36, 48 and 60 months also a significant improvement in comparison to the value before treatment. 
Drugi vprašalniki za bolnike, npr. vprašalnik mednarodnega odbora za dokumentacijo kolenskega sklepa (IKDC - International Knee Documentation Committee, namenjen subjektivni oceni kolena) in vprašalnik po Lysholmu, so po 12, 24, 36, 48 in 60 mesecih prav tako pokazali znatno izboljšanje v primerjavi z vrednostmi pred zdravljenjem.
Patients with local inflammations or acute as well as recent bone or joint infections should be temporarily deferred until the recovery from the infection is documented. 
Previdnostni ukrepi Zdravljenje bolnikov z lokalnim vnetjem ali akutnimi in nedavnimi okužbami kosti ali sklepov je treba začasno odložiti, dokler ni dokazano, da je okužba ozdravljena.
Spherox is not recommended in children or adolescents below 18 years. 
Zdravilo Spherox ni priporočljivo za otroke ali mladostnike, stare manj kot 18 let.
Very important: Carefully comply with the recommendations of your doctor and physical therapist. 
Zelo pomembno: Priporočila svojega zdravnika ali fizioterapevta skrbno upoštevajte.
Be very careful when bending and putting weight on your treated joint. 
Pri upogibanju in obremenjevanju zdravljenega sklepa bodite zelo previdni.
There are no data on possible effects of Spherox treatment on fertility. 
Podatkov o možnih učinkih zdravljenja z zdravilom Spherox na plodnost pri človeku ni.
Twenty-five patients were treated with 10-30 spheroids/cm² defect, 25 with 40-70 spheroids/cm² defect and 25 with 3-7 spheroids/cm² defect. 
Petindvajset bolnikov je bilo zdravljenih z 1030 sferoidi/cm² poškodbe, 25 s 40-70 sferoidi/cm² poškodbe in 25 s 3-7 sferoidi/cm² poškodbe.
Spherox can only be implanted by a specialist doctor in a medical facility and must only be used in the patient for whom it has been prepared. 
Zdravilo Spherox lahko vsadi le zdravnik specialist v zdravstveni ustanovi in je lahko uporabljeno le za bolnika, za katerega je pripravljeno.
Store between 1 °C and 10 °C, do not freeze, do not irradiate, do not open the outer packaging before use to prevent microbial contamination. 
POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte pri temperaturi med 1 °C in 10 °C, ne zamrzujte, ne obsevajte, ne odpirajte zunanje ovojnine pred uporabo, da preprečite okužbe z mikrobi.
Adverse reactions related to the surgical procedure: 
Neželeni učinki, povezani s kirurškim postopkom:
• Measures to ensure the traceability of the product and guarantee the identification of: patient data; diagnosis leading to the treatment; information on biopsy including date of the operation, adverse events reported during the procedure and quality of the biopsy; information on the implant, including all in-process controls and final product controls. 
• ukrepe za zagotavljanje sledljivosti zdravila in zagotovilo o prepoznavanju: podatkov o bolniku; diagnoze, ki je vzrok za zdravljenje; informacij o biopsiji, vključno z datumom operacije; neželenih učinkov, o katerih so poročali med postopkom, in kakovostjo biopsije; informacij o implantatu, vključno z vsemi kontrolami med postopkom in kontrolami končnega zdravila.
The surgical procedure will have a major influence on your ability to drive and use machines. 
Kirurški poseg bo pomembno vplival na vašo sposobnost vožnje in upravljanja strojev.
Your doctor or physical therapist will advise you. 
Svetoval vam bo vaš zdravnik ali fizioterapevt.
The objective of the study is to compare the efficacy and safety of the treatment of cartilage defects (1 to less than 4 cm2) at the femoral condyle of the knee joint with Spherox and microfracture treatment over a period of 5 years. 
Cilj študije je primerjava učinkovitosti in varnosti zdravljenja poškodb hrustanca (velikosti od 1 do manj kot 4 cm2) na femoralnem kondilu kolenskega sklepa z zdravilom Spherox in zdravljenja takih poškodb z mikrofrakturiranjem v obdobju 5 let.
Even if the cartilage sample has already been taken, it may happen that you cannot be treated with Spherox. 
Tudi če je bil vzorec hrustanca že odvzet, se lahko zgodi, da ne boste mogli biti zdravljeni z zdravilom Spherox.
The assessment of the ‘overall KOOS' for the ITT population showed that both treatments yielded a statistically significant improvement relative to baseline (day before arthroscopy). 
Ocena „skupne vrednosti KOOS“ za populacijo ITT je pokazala, da je bilo glede na izhodišče (dan pred artroskopijo) pri obeh zdravljenjih doseženo statistično pomembno izboljšanje.
A GLP-compliant examination of biodistribution and tumourigenicity in NSG mice showed no signs of biodistribution and/or migration from implanted human spheroids. 
Pregled biološke porazdelitve in tumorogenosti v skladu z dobro laboratorijsko prakso pri NSG miših ni pokazal nobenih znakov biološke porazdelitve in/ali migracije iz implantiranih humanih sferoidov.
What you need to know before you are given Spherox 3. 
Kaj morate vedeti, preden boste prejeli zdravilo Spherox 3.
Strictly follow the advice of your doctor or physical therapist. 
Strogo upoštevajte nasvet vašega zdravnika ali fizioterapevta.
IKDC subscores as well as results from the IKDC Current Health Assessment Form and the modified Lysholm score also revealed overall improvements from baseline in both treatment groups with numerically slightly better results in the Spherox group but with no statistical significance. 
Podvrednosti IKDC in rezultati obrazca IKDC za trenutno oceno zdravja (Current Health Assessment Form) ter prilagojena vrednost po Lysholmu so pri obeh skupinah zdravljenja tudi pokazali skupno izboljšanje v primerjavi z izhodiščem, pri čemer so bili rezultati nekoliko boljši v skupini zdravljenja z zdravilom Spherox, vendar razlika ni bila statistično pomembna.
Do not use Spherox if 
Zdravila Spherox ne uporabljajte, če
They are then expected to repair the defect with healthy and functional cartilage over time. 
Pričakuje se, da bodo z zdravim in funkcionalnim hrustancem sčasoma popravili poškodbo.
They are transported in a clear colourless solution. 
Transportirani so v bistri brezbarvni raztopini.
The mean patient age was 34 years (range 19 to 48 years) with a mean body mass index (BMI) of 25.2. 
Povprečna starost bolnikov je znašala 34 let (v razponu od 19 do 48 let), povprečni indeks njihove telesne mase (BMI) pa 25,2.
Untreated bone oedema corresponding with the cartilage defect to be treated may adversely affect the success of the procedure. 
Nezdravljeni kostni edem, ki ustreza poškodbi hrustanca, predvidenega za zdravljenje, lahko negativno vpliva na uspeh postopka.
Also, during the rehabilitation period, the ability to drive and use machines may be restricted due to reduced mobility. 
Tudi v obdobju rehabilitacije je zaradi zmanjšane mobilnosti ta sposobnost vožnje in upravljanja strojev lahko omejena.
The MAH shall ensure that in each Member State where Spherox is marketed, all surgeons and other health professionals who are expected to prescribe and administer the product have access to the educational materials including: 
Imetnik dovoljenja za promet z zdravilom mora poskrbeti, da imajo v vsaki državi članici, v kateri se zdravilo Spherox trži, vsi kirurgi in drugi zdravstveni delavci, za katere se pričakuje, da bodo predpisovali in dajali zdravilo, dostop do izobraževalnega gradiva, ki vključuje:
• blood clot in a deep vein (symptoms: e.g. swelling, pain, increased warmth in the affected area) 
• krvni strdek v globoki veni (simptomi: npr. otekanje, bolečina, občutek povečane toplote na prizadetem območju).
• partial or complete detachment of the tissue beneath the bone and surrounding cartilage 
• delna ali popolna oddvojitev tkiva pod kostjo in sosednjim hrustancem;
Side effects appearing after the implantation of Spherox are mostly related to the surgery. 
Neželeni učinki, ki se pojavijo po vsaditvi zdravila Spherox, so večinoma povezani z operacijo.
• Advanced osteoarthritis of the affected joint (exceeding grade II according to Kellgren and 
• Napredovali osteoartritis prizadetega sklepa (ki presega stopnjo II po Kellgrenu in Lawrenceu).
Due to the nature and intended clinical use of Spherox, conventional studies on pharmacokinetics, absorption, distribution, metabolism, and elimination are not applicable. 
Zaradi lastnosti zdravila Spherox in njegove klinične uporabe običajne študije farmakokinetike, absorpcije, porazdelitve, presnove in izločanja niso smiselne.
Prior to launch of Spherox in each Member State, the Marketing Authorisation Holder (MAH) must agree about the content and format of the training programme and the controlled distribution programme, including communication media, distribution modalities and any other aspects of the programme, with the National Competent Authority. 
Pred prihodom zdravila Spherox na trg v posamezni državi članici se mora imetnik dovoljenja za promet z zdravilom s pristojnim nacionalnim organom dogovoriti o vsebini in obliki programa usposabljanja in programa nadzorovanega razdeljevanja, vključno s sredstvi obveščanja, načini razdeljevanja in vsemi drugimi vidiki programa.
Driving cars and using machines may be limited during the rehabilitation period. 
V rehabilitacijskem obdobju bosta vožnja in upravljanje strojev morda omejeni.
Autologous chondrocyte implantation (ACI) is based on the extraction of the patient's own chondrocytes isolated from healthy cartilage, their culture in vitro and their subsequent implantation into the cartilage defect. 
Implantacija avtolognih hondrocitov (ACI- Autologous chondrocyte implantation) temelji na ekstrakciji bolnikovih lastnih hondrocitov, izoliranih iz zdravega hrustanca, njihovi vzgoji in vitro ter njihovi kasnejši implantaciji v poškodovan hrustanec.
Spherox is not recommended for pregnant or breast-feeding women, as it is applied during surgery. 
Zdravilo Spherox ni priporočljivo za ženske, ki so noseče ali dojijo, saj je dano med operacijo.
• Forms for documentation 
• obrazce za dokumentacijo.
The MAH shall ensure that in each Member State where Spherox is marketed, a system aimed to control access to the product beyond the level of control ensured by routine risk minimisation measures. 
Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da je v vsaki državi članici, v kateri se zdravilo Spherox trži, vzpostavljen sistem nadzorovanega dostopa do zdravila, ki je obsežnejši od nadzora, zagotovljenega z rednimi ukrepi za zmanjševanje tveganj.
On the first visit, the doctor will evaluate your cartilage defect during an exploratory operation. 
Ob prvem obisku bo zdravnik z raziskovalno operacijo ocenil poškodbo hrustanca pri vas.
Too early and vigorous activity may compromise the grafting and the durability of clinical benefit from Spherox. 
Dejavnosti, ki se jih bolnik loti prekmalu in preveč intenzivno, lahko ogrozijo presadek in trajanje kliničnih koristi zdravila Spherox.
If the manufacturing of spheroids has failed or if the release criteria are not fulfilled, e.g. due to insufficient biopsy quality, the medicinal product cannot be delivered. 
Primeri, pri katerih dobava zdravila Spherox ni mogoča Če proizvodnja sferoidov ni uspešna ali če niso izpolnjeni pogoji sprostitve, npr. zaradi nezadostne kakovosti biopsije, zdravila ni mogoče dobaviti.
• swelling due to obstructed flow of tissue fluid via the lymph vessels 
• otekanje zaradi oviranega pretoka tkivne tekočine prek limfnih žil.
In a sheep study, also no biodistribution was observed after injection of spheroids into the knee joint. 
Tudi v študiji, ki je vključevala ovce, biološka porazdelitev po vbrizganju sferoidov v kolenski sklep ni bila opažena.
• increase in size of the cartilage cells, softening of cartilage, disorder of bone formation, death of bone tissue, bone formation outside the skeleton. 
• povečana velikost celic hrustanca; mehčanje hrustanca, motnje nastajanja kosti, odmiranje kostnega tkiva, nastajanje kosti zunaj okostja.
CO.DON AG Warthestraße 21 14513 Teltow Germany 
CO.DON AG, Warthestraße 21, 14513 Teltow, Nemčija
As Spherox is used to repair cartilage defects of the joint and is therefore implanted during a surgical procedure, it is not recommended for use in pregnant or breast-feeding women. 
Ker se zdravilo Spherox uporablja za popravljanje poškodb sklepnega hrustanca in je implantirano med kirurškim posegom, ni priporočljivo za uporabo pri ženskah, ki so noseče ali dojijo.
What Spherox is and what it is used for 2. 
Kaj je zdravilo Spherox in za kaj ga uporabljamo 2.
The implantation must be performed during a surgical procedure (preferably an arthroscopy or miniarthrotomy). 
Implantacijo je treba izvesti med kirurškim posegom (najbolje med artroskopijo ali mini artrotomijo).
A spheroid looks like a tiny pearl made of cartilage cells and cartilage material derived from your own body. 
Sferoid je videti kot droben biser iz hrustančnih celic in hrustančnega materiala, ki izvirajo iz vašega lastnega telesa.
C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION 
DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z ZDRAVILOM
• The patient should document the receipt and understanding of the information on the product 
• bolnik mora podpisati, da je prejel informacije o zdravilu in jih razume,
14513 Teltow, Germany Tel.: +49 3328 43460 Fax: +49 3328 434643 E-mail: info@codon.de 
Tel. št.: +49 (0)3328 43 46 0, faks: +49 (0)3328 43 46 43, e-pošta: info@codon.de
Your cartilage cells are extracted from this sample in a laboratory and are then grown to make the spheroids that constitute Spherox. 
V laboratoriju iz tega vzorca pridobijo celice vašega hrustanca in jih nato gojijo za izdelavo sferoidov, ki sestavljajo zdravilo Spherox.
Spherox is cultured and implanted as three-dimensional spheroids. 
Zdravilo Spherox je vzgojeno in implantirano v obliki tridimenzionalnih sferoidov.
The patient's haemostatic functions should be screened prior to surgery. 
Pred operacijo je treba preveriti hemostatične funkcije pri bolniku.
The catheter of the applicator is made of thermoplastic polyurethane, the sealing plug on one side of acrylonitrile butadiene styrene and a silicone stopper on the other side. 
Kateter aplikatorja je izdelan iz termoplastičnega poliuretana, tesnilni čep na eni strani je izdelan iz akrilonitril butadien stirena, na drugi strani pa je silikonski zamašek.
• hypersensitivity (allergy) (symptoms: e.g. skin reactions, low blood pressure, constriction of airways, swollen tongue or throat, weak and rapid pulse, sickness, vomiting, diarrhoea, dizziness, fainting, fever) 
• preobčutljivost (alergija) (simptomi: npr. kožne reakcije, nizek krvni tlak, zoženje dihalnih poti, otekel jezik ali grlo, šibak in hiter srčni utrip, siljenje na bruhanje, bruhanje, driska, omotica,
Spherox is administered to patients by intraarticular implantation. 
Zdravilo Spherox se daje bolnikom z intraartikularno implantacijo.
The spheroids are provided in a pre-filled syringe or an applicator (stem length 150 mm (co.fix 150)). 
Sferoidi so na voljo v napolnjeni injekcijski brizgi ali aplikatorju (dolžina ročice 150 mm (co.fix 150)).
The risk of treatment failure may increase if you do not follow your rehabilitation schedule. 
Če ne boste sledili časovnemu načrtu svojega rehabilitacijskega programa, se tveganje za neuspeh zdravljenja lahko poveča.
Other medicines and Spherox 
Druga zdravila in zdravilo Spherox
Spheroids are spherical aggregates of ex vivo expanded human autologous chondrocytes and selfsynthesized extracellular matrix. 
Sferoidi so sferični skupki ex vivo ekspandiranih humanih avtolognih hondrocitov in samosintetiziranega zunajceličnega matriksa.
Thromboprophylaxis should be administered according to local guidelines. 
Treba je uvesti tromboprofilakso v skladu z lokalnimi smernicami.
Ex vivo produced spheroids were implanted in mice (subcutaneous implantation of cartilage explants with human spheroids) or in minipigs (autologous spheroids implanted in cartilage defects). 
Sferoidi, pripravljeni ex vivo, so bili implantirani v miši (s subkutano implantacijo humanih sferoidov v eksplantate hrustanca) ali v pritlikave prašiče (avtologni sferoidi, implantirani v poškodbe hrustanca).
Locally applied antibiotics or disinfectants may have potential toxicity on articular cartilage and it is not recommended that Spherox comes into direct contact with those substances. 
Lokalno dani antibiotiki ali razkužila so lahko za artikularni hrustanec strupeni in neposredni stik zdravila Spherox s temi snovmi ni priporočljiv.
Spherox contains so-called spheroids that consist of living cartilage cells with a non-cellular portion for the repair of cartilage defects. 
Zdravilo Spherox vsebuje tako imenovane sferoide iz živih hrustančnih celic z neceličnim delom za popravilo poškodb hrustanca.
INFORMATION IN BRAILLE Justification for not including Braille accepted. 
PODATKI V BRAILLOVI PISAVI Sprejeta je utemeljitev, da Braillova pisava ni potrebna.
If possible, concomitant joint problems should be corrected prior to or at the latest at the time of Spherox implantation. 
Če je mogoče, je treba sočasne težave s sklepi odpraviti pred implantacijo zdravila Spherox ali najkasneje v času implantacije.
A tube may contain a maximum of two co.fix 150. 
Tuba lahko vsebuje največ dva aplikatorja co.fix 150.
A. MANUFACTURER OF THE BIOLOGICAL ACTIVE SUBSTANCE AND MANUFACTURER RESPONSIBLE FOR BATCH RELEASE 
IZDELOVALEC BIOLOŠKE ZDRAVILNE UČINKOVINE IN IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJ
CONTENTS BY WEIGHT, BY VOLUME OR BY UNIT {Number of spheroids} sph 
VSEBINA, IZRAŽENA Z MASO, PROSTORNINO ALI ŠTEVILOM ENOT {Število sferoidov} sferoidov
To make the spheroids, a small cartilage sample is taken from part of one of your joints during a minor operation, and then grown in the laboratory to make the medicine. 
Za izdelavo sferoidov je med manjšo operacijo iz dela enega od vaših sklepov odvzetega malo hrustančnega materiala, ki je nato za izdelavo zdravila vzgajan v laboratoriju.
1 syringe in a sterile tube 
1 injekcijska brizga v sterilni tubi.
The safety and efficacy of Spherox in patients with cartilage defects outside the femoral condyle and the patella of the knee have not been established. 
Varnost in učinkovitost zdravila Spherox pri bolnikih s poškodbo hrustanca zunaj femoralnega kondila in pogačice kolena še nista bili dokazani.
METHOD OF ADMINISTRATION For intraarticular use 
POSTOPEK UPORABE za intraartikularno uporabo
Spherox is delivered to the doctor in a container ready for application. 
Zdravilo Spherox je zdravniku dobavljeno v vsebniku in je pripravljeno za uporabo.
Magnetic resonance imaging (MRI) results according to the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring system (0 = worst result; 100 = best result) showed an improvement within the first 60 months from 59.8 at Visit 2 (3 months after treatment) up to 75.0 points in the group of patients treated with 3-7 spheroids/cm² defect, from 64.5 at Visit 2 up to 76.4 points in the dose group of 10-30 spheroids/cm² defect, and from 64.7 at Visit 2 up to 73.6 points in the dose group of 40-70 spheroids/cm² defect. 
Rezultati slikanja z magnetno resonanco (MRI) so glede na sistem točkovanja glede na opazovanje popravljenega tkiva hrustanca z magnetno resonanco (MOCART - Magnetic Resonance Observation of Cartilage Repair Tissue) (0 = najslabši rezultat; 100 = najboljši rezultat) v prvih 60 mesecih pokazali izboljšanje v skupini bolnikov, zdravljenih s 3-7 sferoidi/cm² poškodbe, z 59,8 točke pri drugem obisku (3 mesece po zdravljenju) na 75,0 točke, v skupini bolnikov z odmerkom 1030 sferoidov/cm² poškodbe izboljšanje s 64,5 točke ob drugem obisku na 76,4 točke, v skupini bolnikov z odmerkom 40-70 sferoidov/cm² poškodbe pa izboljšanje s 64,7 točke ob drugem obisku na
Spherox is used to treat defects up to 10 cm² in size. 
Zdravilo Spherox se uporablja za zdravljenje poškodb z velikostjo do 10 cm².
What you need to know before you are given Spherox 
Kaj morate vedeti, preden boste prejeli zdravilo Spherox