natgillin/translations-raw huggingface dataset:
Indinavir AUC: ↓ 32 % Indinavir Cmin: ↓ 40 % (Relative to Indinavir 800 mg TID alone) 
AUC indinavirja: ↓ 32 % Cmin indinavirja: ↓ 40 % (glede na samostojno uporabljen 800 mg TID)
ANTIASTHMATIC Theophylline 250 mg SD (Indinavir 800 mg TID) 
ANTIASTMATIKI Teofilin 250 mg SD (indinavir 800 mg TID)
The bottle contains desiccant canisters that should remain in the bottle. 
V plastenki je sušilno sredstvo, ki mora v njej tudi ostati.
Adverse reactions have also been reported during post-marketing experience* as they are derived from spontaneous reports, incidences cannot be determined. 
O neželenih učinkih so poročali tudi v obdobju trženja*.
Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4). 
Vendar pa je čas do razvoja bolezni različen, pri čemer se le te lahko pojavijo več mesecev po začetku zdravljenja (glejte poglavje 4.4).
CRIXIVAN 400 mg hard capsules are supplied in HDPE bottles with a polypropylene cap and a foil seal containing 90 or 180 capsules. 
CRIXIVAN 400 mg trde kapsule so na voljo v HDPE plastenkah s polipropilenskim zamaškom in zaščitno folijo.
• dexamethasone - used to stop swelling (inflammation) 
• deksametazon - za preprečevanje otekanja (vnetja)
Indinavir AUC and Cmin: ↔ (Relative to Indinavir 800 mg TID alone*) 
AUC in Cmin indinavirja: ↔ (glede na samostojno uporabljen 800 mg TID*)
Saquinavir AUC:  620 % Saquinavir Cmin:  450 % (Relative to saquinavir 800 mg SD (soft gel formulation) alone) 
AUC sakvinavirja:  620 % Cmin sakvinavirja:  450 % (glede na samostojni sakvinavir 800 mg SD (formulacija z mehkim gelom))
Vardenafil dose should not exceed a maximum of 2.5 mg in a 72-hour period when given with a boosted protease inhibitor. 
Kadar se vardenafil daje skupaj z okrepljenim zaviralcem proteaze, njegov odmerek v 72-ih urah ne sme preseči maksimalnega odmerka 2,5 mg.
CRIXIVAN 200 mg - packs of 180, 270 and 360 capsules - Bottle label 
CRIXIVAN 200 mg - pakiranje po 180, 270 in 360 kapsul - nalepka na plastenki
At steady state following a dose regimen of 800 mg every 8 hours, HIV-seropositive adult patients in one study achieved geometric means of: AUC0-8h of 27,813 nM*h (90 % confidence interval = 22,185, 34,869), peak plasma concentrations 11,144 nM (90 % confidence interval = 9,192, 13,512) and plasma concentrations at 8 hours post dose 211 nM (90 % confidence interval = 163, 
V stanju dinamičnega ravnovesja po jemanju 800 mg odmerkov vsakih 8 ur so bile v raziskavi pri HIV-seropozitivnih bolnikih dosežene naslednje geometrične srednje vrednosti: AUC0-8h 27.813 nM*h (90 % interval zaupanja = 22.185, 34.869), najvišje plazemske koncentracije 11.144 nM (90 % interval zaupanja = 9.192, 13.512) in plazemske koncentracije 8 ur po zaužitju zdravila 211 nM (90 % interval zaupanja = 163, 274).
Indinavir Cmin: ↑ 118 % (Relative to Indinavir 800 mg TID alone) 
Cmin indinavirja: ↑ 118 % (glede na samostojno uporabljen 800 mg TID)
The metabolism of indinavir is mediated by the cytochrome P450 enzyme CYP3A4. 
Presnova indinavirja poteka preko encima CYP3A4 citokromskega sistema P450.
Indinavir and fluconazole can be co-administered without dose adjustment. 
Indinavir in flukonazol se lahko uporabljata sočasno brez prilagajanja odmerka.
A dose increase of indinavir to 1,000 mg every 8 hours should be considered if given with nevirapine. 
Če se indinavir daje skupaj z nevirapinom, je treba razmisliti o povečanju odmerka indinavirja na 1.000 mg na vsakih 8 ur.
Medicinal product resistance 
Rezistenca na zdravilo
• indigestion or diarrhoea 
• prebavne težave ali driska
See Section 3 below for information on how to take CRIXIVAN. 
Zdravilo CRIXIVAN skupaj s hrano in pijačo Za informacije, kako jemati zdravilo CRIXIVAN, glejte poglavje 3.
The capsules are semi-translucent white and coded ‘CRIXIVAN 400 mg' in green. 
Kapsule so polprosojne, bele, z oznako ‘CRIXIVAN 400 mg' zelene barve.
Indinavir Cmin: ↑ 49 % (Relative to Indinavir 800 mg TID alone) 
Cmin indinavirja: ↑ 49 % (glede na samostojno uporabljen 800 mg TID)
Interaction with indinavir/ritonavir not studied Decreased indinavir concentrations and increased rifabutin concentrations are expected. 
Pričakujejo se zmanjšane koncentracije indinavirja in povečane koncentracije rifabutina.
Indinavir AUC and Cmin:  (Relative to Indinavir 400 mg SD alone) 
AUC in Cmin indinavirja:  (glede na samostojno uporabljen 400 mg SD)
Indinavir and sulphamethoxazole/ trimethoprim can be coadministered without dose adjustment. 
Indinavir in sulfametoksazol/trimetopri m se lahko uporabljajo sočasno brez prilagajanja odmerka.
CRIXIVAN 400 mg - packs of 90 and 180 capsules - Bottle label 
CRIXIVAN 400 mg - pakiranje po 90 in 180 kapsul - škatla
Capsule shell: gelatin titanium dioxide (E 171) printing ink: indigo carmine (E 132). 
Ovojnica kapsule želatina titanov dioksid (E 171) črnilo za potiskanje: indigo karmin (E 132)
Anticoagulation parameters should be monitored when warfarin is coadministered with indinavir/ritonavir. 
Kadar se varfarin uporablja sočasno z indinavirjem/ritonavirjem, je treba spremljati antikoagulacijske parametre.
Medical management in patients with one or more episodes of nephrolithiasis must include adequate hydration and may include temporary interruption of therapy (e.g., 1 to 3 days) during the acute episode of nephrolithiasis or discontinuation of therapy. 
Če se pojavijo znaki in simptomi ledvičnih kamnov, vključno z bolečinami v ledvenem predelu in s hematurijo (vključno z mikrohematurijo) ali brez nje, lahko razmislimo o začasni prekinitvi zdravljenja (npr. za 1-3 dni) med akutnimi napadi zaradi ledvičnih kamnov ali o prenehanju zdravljenja.
Sildenafil dose should not exceed a maximum of 25 mg in a 48-hour period in patients receiving concomitant indinavir therapy. 
Pri bolnikih, ki sočasno prejemajo indinavir, odmerek sildenafila v 48-ih urah ne sme preseči maksimalnega odmerka 25 mg.
Didanosine enteric-coated 400 mg SD (Indinavir 800 mg SD) 
Gastrorezistentni didanozin 400 mg SD (indinavir 800 mg SD)
Coadministration of CRIXIVAN with tadalafil is likely to result in an increase of tadalafil by competitive inhibition of metabolism. 
Verjetno je, da bo sočasna uporaba zdravila CRIXIVAN in tadalfila povzročila povečanje ravni tadalfila zaradi kompetitivnega zaviranja presnove.
• vomiting 
• vetrovi
Indinavir is rapidly absorbed in the fasted state with a time to peak plasma concentration of 0.8 hours ± 0.3 hours (mean ± S.D.). 
Najvišjo plazemsko koncentracijo doseže po 0,8 ure  0,3 ure (povprečje  S.D.).
CRIXIVAN 200 mg - packs of 180, 270 and 360 capsules - Outer carton 
CRIXIVAN 200 mg - pakiranje po 180, 270 in 360 kapsul - škatla
A greater than dose-proportional increase in indinavir plasma concentrations was observed over the 200 - 800 mg dose range. 
Pri odmerkih med 200 in 800 mg so opazili večje plazemske koncentracije, kot bi bilo to sorazmerno z odmerkom.
Indinavir Cmin:  (Relative to Indinavir 1,000 mg TID alone) 
Cmin indinavirja:  (glede na samostojno uporabljen 1000 mg TID)
printing ink: titanium dioxide (E 171), indigo carmine (E 132) and iron oxide (E 172). 
Ovojnica kapsule želatina titanov dioksid (E171) črnilo za potiskanje: titanov dioksid (E 171), indigo karmin (E 132) in železov oksid (E 172)
What CRIXIVAN contains 
Kaj vsebuje zdravilo CRIXIVAN
Recommendations concerning co-administration 
Priporočila o sočasnem dajanju
Indinavir and theophylline can be co-administered without dose adjustment. 
Indinavir in teofilin se lahko uporabljata sočasno brez prilagajanja odmerka.
Indinavir and methadone can be co-administered without dose adjustment. 
Indinavir in metadon se lahko uporabljata sočasno brez prilagajanja odmerka.
An increased incidence of nephrolithiasis has been observed in patients with underlying liver disorders when treated with indinavir. 
Pri bolnikih z že obstoječimi motnjami v delovanju jeter so opazili povečano pojavnost ledvičnih kamnov, ko so bili zdravljeni z indinavirjem.
Vardenafil dose should not exceed a maximum of 2.5 mg in a 24-hour period in patients receiving concomitant indinavir therapy. 
Pri bolnikih, ki sočasno prejemajo indinavir, odmerek vardenafila v 24-ih urah ne sme preseči maksimalnega odmerka 2,5 mg.
Interaction with indinavir/ritonavir not studied Morphine levels may be decreased due to induction of glucuronidation by coadministered ritonavir. 
Ravni morfina se lahko znižajo zaradi indukcije glukuronidacije, ki jo povzroča sočasno uporabljen ritonavir.
Anhydrous lactose. 
Brezvodna laktoza.
Theophylline AUC and Cmin: ↔ 
AUC in Cmin teofilina: ↔
The capsules are semi-translucent white and coded ‘CRIXIVAN 200 mg' on them in blue. 
Kapsule so polprosojne, bele, z oznako ‘CRIXIVAN 200 mg' modre barve.
It is important that you take CRIXIVAN exactly as your doctor tells you to - he or she will tell you how long you should take your medicine. 
Zdravnik vam bo povedal, kako dolgo morate jemati zdravilo.
Cases of interstitial nephritis with medullary calcification and cortical atrophy have been observed in patients with asymptomatic severe leucocyturia (> 100 cells/high power field). 
Pri bolnikih s hudo asimptomatsko levkociturijo (>100 celic/ vidno polje mikroskopa pri veliki povečavi) so opazili primere intersticijskega nefritisa s kalcifikacijo medule in atrofijo korteksa.
Saquinavir 1,200 mg SD (soft gel capsule formulation) (Indinavir 800 mg TID) 
Sakvinavir 1200 mg SD (formulacija kapsule z mehkim gelom) (indinavir 800 mg TID)
CRIXIVAN and oral midazolam should not be coadministered (see section 4.3). 
Zdravilo CRIXIVAN in peroralni midazolam se ne smeta dajati sočasno (glejte poglavje 4.3).
What CRIXIVAN is 
Kaj je zdravilo CRIXIVAN
Very common asthenia/fatigue, taste perversion, abdominal pain. 
Splošne težave in spremembe na mestu aplikacije zelo pogosti utrujenost/šibkost, motnje okušanja, bolečine v trebuhu
Saquinavir 800 mg SD (soft gel capsule formulation) (Indinavir 800 mg TID) 
Sakvinavir 800 mg SD (formulacija kapsule z mehkim gelom) (indinavir 800 mg TID)
Anti-Mycobacterial Isoniazid 300 mg QD (Indinavir 800 mg TID) 
Antimikobakterijska zdravila Izoniazid 300 mg QD (indinavir 800 mg TID)
Blood and lymphatic system disorders 
Bolezni krvi in limfatičnega sistema zelo pogosti neznana*
Coadministration of CRIXIVAN with vardenafil is likely to result in an increase of vardenafil by competitive inhibition of metabolism. 
Verjetno je, da bo sočasna uporaba zdravila CRIXIVAN in vardenafila povzročila povečanje ravni vardenafila zaradi kompetitivnega zaviranja presnove.
This means you will take a total of twelve 200 mg capsules (2400 mg) each day. 
To pomeni, da boste vzeli skupaj dvanajst 200 mg kapsul (2.400 mg) vsak dan.
Frequency Adverse reactions CRIXIVAN 
Neželeni učinki CRIXIVAN
CRIXIVAN 200 mg hard capsules 
CRIXIVAN 200 mg trde kapsule
Decreases in methadone AUC has been observed with other ritonavir-boosted protease inhibitors. 
Pri zaviralcih proteaze, okrepljenih z ritonavirjem, so opazili zmanjšanje AUC metadona.
Careful monitoring of serum levels or therapeutic effects is recommended when these medicines are concomitantly administered with indinavir/ritonavir. 
Kadar se ta zdravila uporabljajo sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje ravni v serumu ali terapevtskih učinkov.
This means you will take a total of two 400 mg capsules (800 mg) each day. 
To pomeni, da boste vzeli skupaj dve 400 mg kapsuli (800 mg) vsak dan.
CRIXIVAN 400 mg hard capsules 
CRIXIVAN 400 mg trde kapsule
CRIXIVAN with ritonavir and oral midazolam should not be coadministered (see section 4.3). 
Zdravilo CRIXIVAN z ritonavirjem in peroralni midazolam se ne smeta dajati sočasno (glejte poglavje 4.3).
This is because these foods stop your body being able to take in as much CRIXIVAN and it will not work as well. 
Takšna hrana namreč zmanjšuje absorpcijo zdravila CRIXIVAN in s tem njegovo učinkovitost.
This means you will take a total of four 200 mg capsules (800 mg) each day. 
To pomeni, da boste vzeli skupaj štiri 200 mg kapsule (800 mg) vsak dan.
Coadministration of CRIXIVAN with sildenafil is likely to result in an increase of sildenafil by competitive inhibition of metabolism. 
Verjetno je, da bo sočasna uporaba zdravila CRIXIVAN in sildenafila povzročila povečanje ravni sildenafila zaradi kompetitivnega zaviranja presnove.
Careful monitoring of therapeutic and adverse effects is recommended when erythromycin or itraconazole are concomitantly administered with indinavir/ritonavir. 
Kadar se eritromicin in itrakonazol uporabljata sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
Two clinical trials in 41 paediatric patients (4 to 15 years of age) were designed to characterise the safety, antiretroviral activity, and pharmacokinetics of indinavir in combination with stavudine and lamivudine. 
Da bi označili varnost, protiretrovirusno aktivnost in farmakokinetiko indinavirja v kombinaciji s stavudinom in lamivudinom pri pediatričnih bolnikih, so oblikovali dve klinični raziskavi, ki vključujeta 41 pediatričnih bolnikov (starih 4 do 15 let).
Indinavir Cmin:  (Relative to Indinavir 800 mg TID alone) 
Cmin indinavirja:  (glede na samostojno uporabljen 800 mg TID)
An increase in thyroidal weight and thyroidal follicular cell hyperplasia, due to an increase in thyroxine clearance, was seen in rats treated with indinavir at doses  160 mg/kg/day. 
Pri podganah, ki so jih zdravili z indinavirjem v odmerkih ≥ 160 mg/kg/dan, je zaradi povečanja očistka tiroksina prišlo do povečanja mase ščitnice in do hiperplazije folikularnih celic ščitnice.
Fluconazole 400 mg QD (Indinavir 1,000 mg TID) 
Antimikotiki Flukonazol 400 mg QD (indinavir 1000 mg TID)
This means you will take a total of six 400 mg capsules (2400 mg) each day. 
To pomeni, da boste vzeli skupaj šest 400 mg kapsul (2.400 mg) vsak dan.
CRIXIVAN 200 mg hard capsules indinavir 
CRIXIVAN 200 mg trde kapsule indinavir
Indinavir and cimetidine can be co-administered without dose adjustment. 
Indinavir in cimetidin se lahko uporabljata sočasno brez prilagajanja odmerka.
Alternatively, CRIXIVAN may be administered with a low-fat, light meal. 
Izjemoma se ga lahko jemlje skupaj z lahkim obrokom z malo maščobami.
Inform your doctor as soon as possible if you develop severe muscle pain or weakness. 
Če se pojavijo hude bolečine v mišicah ali mišična oslabelost, se takoj, ko je mogoče, posvetujte z zdravnikom.
CRIXIVAN 400 mg hard capsules Indinavir 
CRIXIVAN 400 mg trde kapsule indinavir
Efavirenz AUC and Cmin : ↔ 
AUC in Cmin efavirenza: ↔
Tadalafil dose should not exceed a maximum of 10 mg in a 72 hour period in patients receiving concomitant indinavir therapy. 
Pri bolnikih, ki sočasno prejemajo indinavir, odmerek tadalfila v 72-ih urah ne sme preseči maksimalnega odmerka 10 mg.
Indinavir AUC24hr:220 % Indinavir Cmin:↑ 24-fold (Relative to Indinavir 800 mg TID alone*) Ritonavir AUC24hr:  
AUC24 h indinavirja:  220 % Cmin indinavirja: ↑ 24-krat (glede na samostojno uporabljen 800 mg TID*)
Interaction with indinavir/ritonavir not studied Ritonavir induces glucuronidation and as a result is expected to decrease the plasma concentrations of atovaquone. 
Ritonavir inducira glukuronidacijo, zato se pričakuje zmanjšana koncentracija atovakona v plazmi.
Always take this medicine exactly as your doctor, pharmacist or nurse has told you. 
Pri jemanju tega zdravila natančno upoštevajte navodila zdravnika ali farmacevta.
• dry mouth 
• odrevenelost ust
Dose reduction of CRIXIVAN to 600 mg every 8 hours is recommended with administering itraconazole concurrently. 
Pri sočasni uporabi z itrakonazolom se priporoča zmanjšanje odmerka zdravila CRIXIVAN na 600 mg na vsakih 8 ur.
Interaction with indinavir/ritonavir not studied Ritonavir may modify P-glycoprotein mediated fexofenadine efflux when coadministered resulting in increased concentrations of fexofenadine. 
Ritonavir lahko ob sočasnem dajanju spremeni izliv feksofenadina, ki ga povzroča Pglikoprotein, kar povzroča povečane koncentracije feksofenadina.
Saquinavir 600 mg SD (hard gel capsule formulation) (Indinavir 800 mg TID) 
Sakvinavir 600 mg SD (formulacija kapsule s trdim gelom) (indinavir 800 mg TID)
Careful monitoring of therapeutic and adverse effects is recommended when these medicines are concomitantly administered with indinavir. 
Kadar se ta zdravila uporabljajo sočasno z indinavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
Indinavir and NRTIs can be co-administered without dose adjustment. 
Indinavir in zaviralci NRT se lahko uporabljajo sočasno brez prilagajanja odmerka.
Medicinal product interactions 
FARMACEVTSKI PODATKI
A dose reduction of ketoconazole should be considered when coadministered with indinavir/ritonavir. 
Pri sočasnem dajanju z indinavirjem/ritonavirjem je treba razmisliti o zmanjšanju odmerka ketokonazola.
Indinavir AUC24hr: 178 % Indinavir Cmin:11-fold; (Relative to Indinavir 800 mg TID alone*) Ritonavir AUC:  72 % Ritonavir Cmin:  62 % 
AUC24 h indinavirja:  178 % Cmin indinavirja:  11-krat (glede na samostojno uporabljen 800 mg TID*)
Careful monitoring of therapeutic and adverse effects is recommended when morphine is concomitantly administered with indinavir/ritonavir. 
Kadar se morfin uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
CRIXIVAN 200 mg hard capsules are supplied in HDPE bottles with a polypropylene cap and a foil seal containing 180, 270 or 360 capsules. 
CRIXIVAN 200 mg trde kapsule so na voljo v HDPE plastenkah s polipropilenskim zamaškom in zaščitno folijo.
• Do not take CRIXIVAN with food that is high in calories, fat and protein. 
• Ne jemljite zdravila CRIXIVAN z visokokaloričnim obrokom, bogatim z maščobami in proteini, ker to zmanjšuje zmožnost absorpcije zdravila v telesu in s tem njegovo učinkovitost.
Caution is warranted and therapeutic concentration monitoring is recommended for quinidine when coadministered with CRIXIVAN. 
Kadar se kinidin daje sočasno z zdravilom CRIXIVAN, je treba biti previden in spremljati terapevtsko koncentracijo.
ANTIHISTAMINES Fexofenadine 
ANIHISTAMINIKI Feksofenadin
Indinavir AUC24hr:68 % Indinavir Cmin: ↑ 10-fold (Relative to Indinavir 800 mg TID alone*) Ritonavir AUC24hr:  
AUC24 h indinavirja:  68 % Cmin indinavirja: ↑ 10-krat (glede na samostojno uporabljen 800 mg TID*)
How to store CRIXIVAN 
Shranjevanje zdravila CRIXIVAN
Careful monitoring of therapeutic and adverse effects is recommended when carbamazepine is concomitantly administered with indinavir/ritonavir. 
Kadar se karbamazepin uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
Combinations of atazanavir with or without ritonavir and Crixivan have not been studied and co-administration of these medicinal products is not recommended due to risk of worsening of these adverse reactions. 
Kombinacij atazanavirja z ritonavirjem ali brez skupaj z zdravilom Crixivan niso preučevali.
Indinavir and isoniazid can be co-administered without dose adjustment. 
Indinavir in izoniazid se lahko uporabljata sočasno brez prilagajanja odmerka.
Careful monitoring of therapeutic and adverse effects is recommended when ketoconazole is concomitantly administered with indinavir/ritonavir. 
Kadar se ketokonazol uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of ketoconazole. 
Indinavir in ritonavir zavirata CYP3A4, zato se pričakuje, da bosta povečala koncentracije ketokonazola v plazmi.
Erythromycin, Itraconazole Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of erythromycin and itraconazole. 
Indinavir in ritonavir zavirata CYP3A4, zato se pričakuje povečana koncentracija eritromicina in itrakonazola v plazmi.
Careful monitoring of therapeutic and adverse effects is recommended when fentanyl is concomitantly administered with indinavir/ritonavir. 
Kadar se fentanil uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of carbamazepine. 
Indinavir in ritonavir zavirata CYP3A4, zato se pričakuje povečana koncentracija karbamazepina v plazmi.
Careful monitoring of therapeutic and adverse effects is recommended when buspirone is concomitantly administered with indinavir/ritonavir. 
Kadar se buspiron uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
 dihydropyridine calcium channel blocker concentration 
 koncentracija blokatorja kalcijevih kanalčkov, dihidropiridinskega tipa
Careful monitoring of therapeutic and adverse effects is recommended when loratidine is concomitantly administered with indinavir/ritonavir. 
Kadar se loratidin uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
8 hours, produced AUC0-8hr values of 27,412 nM*h, peak plasma concentrations of 12,182 nM, and plasma concentrations at 8 hours post dose of 122 nM. 
Pri s HIV okuženih pediatričnih bolnikih so bile pri jemanju trdih kapsul indinavirja v odmerkih 500 mg/m2 vsakih 8 ur AUC0-8h vrednosti 27.412 nM*h, najvišje plazemske koncentracije 12.182 nM, plazemske koncentracije 8 ur po odmerku pa 122 nM. AUC in najvišje plazemske koncentracije so bile večinoma podobne tistim pri s HIV okuženih odraslih, ki so prejemali priporočeni odmerek 800 mg vsakih 8 ur.
Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of fentanyl. 
Indinavir in ritonavir zavirata CYP3A4, zato se pričakuje povečana koncentracija fentanila v plazmi.
*)historical controls 
Iz preteklih kontrolnih raziskav.
Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported to occur in the setting of immune reactivation; however, the reported time to onset is more variable and these events can occur many months after initiation of treatment. 
Poročali so tudi o pojavu avtoimunih bolezni (kot sta Gravesova bolezen in avtoimunski hepatitis) ob imunski reaktivaciji.
Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of loratidine. 
Indinavir in ritonavir zavirata CYP3A4, zato se pričakuje povečana koncentracija loratidina v plazmi.
Interaction study with Lopinavir/ritonavir + rosuvastatin: 
Študija o medsebojnem delovanju med lopinavirjem/ritonavirjem in rosuvastatinom: AUC rosuvastatina  2,08-krat;
Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of buspirone. 
Indinavir in ritonavir zavirata CYP3A4, zato se pričakuje povečana koncentracija buspirona v plazmi.
Careful monitoring of therapeutic and adverse effects is recommended when dexamethasone is concomitantly administered with indinavir/ritonavir. 
Kadar se deksametazon uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.
Interaction with indinavir/ritonavir not studied Indinavir and ritonavir inhibit CYP3A4 and as a result are expected to increase the plasma concentrations of tacrolimus. 
Indinavir in ritonavir zavirata CYP3A4, zato se pričakuje povečana koncentracija takrolimusa v plazmi.
Careful monitoring of therapeutic and adverse effects is recommended when atovaquone is concomitantly administered with indinavir/ritonavir. 
Kadar se atovakon uporablja sočasno z indinavirjem/ritonavirjem, se priporoča skrbno spremljanje terapevtskih in neželenih učinkov.