natgillin/translations-raw huggingface dataset:
• if they drink alcohol 
• ki uživajo alkohol.
(see section 4.3) 
(glejte poglavje 4.4).
• Tingling or numbness around the lips and mouth. 
• Ščemenje ali otrplost okoli ustnic in ust.
Results through 48 weeks of treatment are provided below. 
Rezultati po 48 tednih zdravljenja so navedeni v nadaljevanju.
Data from this small number further analysed by GSS subgroups need to be interpreted with caution. 
Podatke o tem majhnem številu bolnikov je potrebno, pri nadaljni analizi po podskupinah GSS, interpretirati previdno.
• Feeling tired 
• Utrujenost.
Study performed with amprenavir. 
Študija izvedena z amprenavirjem.
The decrease of (R-) methadone (active enantiomer) is not expected to be clinically significant. 
Za zmanjšanje (R-) metadona (aktivni enantiomer) ni pričakovano, da bo klinično pomembno.
• methadone (a heroin substitute) 
• metadon (nadomestek heroina)
(listed in section 6), or to ritonavir. 
(navedeno v poglavju 6) ali ritonavir.
• fluticasone propionate and similar medicines used to treat asthma, unless considered essential. 
• flutikazonpropionat in podobna zdravila za zdravljenje astme, razen če je nujno potrebno.
79 % of subjects received greater than 48 weeks of exposure. 
79 % bolnikov je bilo zdravljenju izpostavljenih več kot 48 tednov.
No dose recommendation can be made for children and adolescents with hepatic impairment as no studies have been conducted in these age groups. 
Za odmerke pri otrocih in mladostnikih z okvaro jeter ni mogoče dati priporočil, ker študije v teh starostnih skupinah niso bile izvedene.
Week 48 AAUCMB (n) 
Teden 48 AAUCMB (n)
These symptoms are probably caused by the body's immune system becoming stronger, so that the body starts to fight these infections. 
Ti simptomi so verjetno posledica okrepitve telesnega imunskega sistema, ko se telo lahko začne boriti s temi okužbami.
Following completion of the 48 week treatment period, subjects at European and Canadian sites were eligible to participate in a study extension to Week 144 maintaining their treatment regimen as per the original randomisation. 
Po koncu 48-tedenskega obdobja zdravljenja so lahko preiskovanci na evropskih in kanadskih raziskovalnih mestih sodelovali v nadaljevanju študije do 144. tedna, pri čemer so ohranili shemo zdravljenja po prvotni randomizaciji.
• warfarin and other medicines that stop blood clotting 
• varfarin in druga zdravila za preprečevanje nastajanja krvnih strdkov
If you forget to take a dose of Telzir, take it as soon as you remember and then continue your treatment as before. 
Če ste pozabili vzeti odmerek zdravila Telzir, ga vzemite takoj, ko se spomnite, nato pa nadaljujte z jemanjem zdravila kot pred tem.
Do not take Telzir: 
Ne jemljite zdravila Telzir:
Severe and life-threatening skin reactions, including Stevens-Johnson syndrome, were reported in less than 1% of patients included in the clinical development programme. 
O hudih in smrtno nevarnih kožnih reakcijah, vključno s Stevens-Johnsonovim sindromom, so poročali pri manj kot 1% bolnikov, ki so bili vključeni v klinični razvojni program.
You must check the list of medicines under 'Don't take Telzir' at the beginning of section 2 of this leaflet. 
Preverite seznam teh zdravil pod 'Ne jemljite zdravila Telzir' na začetku poglavja 2 tega navodila.
Significant ↓ APV expected 
Signifikantno  APV pričakovano
Resistance patterns were similar to those observed in adults. 
Vzorci odpornosti so bili podobni kot pri odraslih.
It is very important that you take the full daily dose of Telzir and ritonavir as prescribed by your doctor. 
Zelo pomembno je, da vzamete celoten dnevni odmerek zdravila Telzir in ritonavirja, kot vam je predpisal zdravnik.
Throw away the bottle 28 days after first opening it, but do not throw away any medicines via wastewater or household waste. 
Plastenko 28 dni po prvem odprtju zavrzite, vendar zdravila ne smete zavreči v odpadne vode ali med gospodinjske odpadke.
The suspension is white to off-white in colour. 
Suspenzija je bele do sivo bele barve.
Children less than 6 years of age Telzir is not recommended for children less than 6 years old. 
Otroci, mlajši od 6 let Zdravilo Telzir ni priporočljivo za otroke, mlajše od 6 let.
Let them dry completely before you use them again. 
Pred ponovno uporabo morata biti popolnoma suha.
On rare occasions, these muscle disorders have been serious (rhabdomyolysis). 
V redkih primerih so bile te mišične težave hude (rabdomioliza).
Please refer to the relevant product information for these medications (see section 4.5). 
Prosimo glejte relevantne informacije o zdravilih za ta zdravila (glejte poglavje 4.5).
33-38 kg Oral suspension 
33-38 kg Peroralna suspenzija
• Skin rashes (red, raised or itchy) - if the skin rash is severe, you may have to stop taking this medicine 
• Kožni izpuščaj (rdeč, privzdignjen ali srbeč) - če je kožni izpuščaj hud, bo zdravljenje s tem zdravilom morda treba prekiniti.
Like all medicines, this medicine can cause side effects, but not everyone gets them. 
Kot vsa zdravila ima lahko tudi to zdravilo neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
Tell your doctor or pharmacist if you're taking or have recently taken any other medicinesthese include herbal medicines or other medicines you bought without a prescription. 
Obvestite svojega zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali boste začeli jemati katerokoli zdravilo - vključno z zdravili iz zelišč in drugimi zdravili, ki ste jih dobili brez recepta.
• Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached. 
• ob vsakršni spremembi sistema za obvladanje tveganj, zlasti kadar jr tovrstna sprememba posledica prejema novih informacij, ki lahko vplivajo do znatne spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmajševanjem tveganja).
Hertfordshire SG12 0DJ United Kingdom 
Hertfordshire SG12 0DJ Velika Britanija
• The active substance is fosamprenavir. 
• Učinkovina je fosamprenavir.
• If you have a known allergy to medicines containing sulphonamide. 
• Če ste alergični na zdravila, ki vsebujejo sulfonamide.
A 75 % reduction of the standard rifabutin dose (i.e. to 150 mg every other day) is recommended. 
Priporočeno je 75 % zmanjšanje standardnega odmerka rifabutina (na 150 mg vsak drug dan).
What Telzir is and what it is used for 
Kaj je zdravilo Telzir in za kaj ga uporabljamo
Therefore, no recommendations can be made in this patient population. 
Zato se tega zdravila ne priporoča pri tej skupini bolnikov.
High doses (> 200 mg/day) of ketoconazole or itraconazole are not recommended. 
Visoki odmerki (> 200 mg/dan) ketokonazola ali itrakonazola niso priporočeni.
The dose recommendations for this population therefore take into account the observed food effect (see section 4.2). 
Priporočila za odmerjanje za to populacijo upoštevajo opaženi učinek hrane (glejte poglavje 4.2).
Women who are HIV-positive must not breast-feed because HIV infection can be passed on to the baby in breast milk. 
HIV-pozitivne ženske ne smejo dojiti, saj se okužba z virusom HIV lahko z mlekom prenese na dojenega otroka.
Amprenavir exposure unchanged when compared to historical data. 
Izpostavljenost amprenavirju je bila nespremenjena v primerjavi s preteklimi podatki.
Most of the adverse reactions below were reported from three large clinical studies in adults, where the adverse events were of at least moderate intensity (Grade 2 or more) occurring in at least 1% of patients and reported by investigators as being attributable to the medicinal products used in the studies. 
O večini neželenih učinkov, navedenih v nadaljevanju, so poročali v treh obsežnih kliničnih študijah pri odraslih, kjer so bili neželeni učinki vsaj zmerne intenzitete (stopnje 2 ali več), ki so se pojavili pri vsaj 1 % bolnikov, in so jih raziskovalci pripisali zdravilom, uporabljenim v študijah.
Children less than 6 years of age 
Otroci, mlajši od 6 let
• Flare up of old infections 
• ponovitev starih okužb
These ingredients may cause allergic reactions (sometimes delayed). 
Ti dve pomožni snovi lahko povzročita alergijske reakcije (lahko zapoznele).
It should be noted that the Telzir oral suspension has not been evaluated clinically in adults and that the adverse reaction profile detailed in this section is based on the experience in adults with the Telzir film coated tablets. 
Poudariti je potrebno, da peroralna suspenzija Telzir klinično na odraslih bolnikih ni bila ovrednotena in da profil neželenih reakcij, ki so navedeni v tem poglavju, temelji na izkušnjah s filmsko obloženimi tabletami Telzir pri odraslih.
Please read the information on ‘Other side effects of combination therapy for HIV' in section 4 of this leaflet. 
Preberite informacije pod ' Drugi neželeni učinki kombiniranega zdravljenja okužbe z virusom HIV' v poglavju 4 tega navodila.
Only 22% of the original population of the KLEAN study was enrolled in the study extension. 
V nadaljevanje študije je bilo vključene le 22 % prvotne populacije študije KLEAN.
You may also be allergic to Telzir. 
V tem primeru ste lahko alergični tudi na zdravilo Telzir.
• if you are allergic to fosamprenavir, amprenavir or any of the other ingredients of this medicine 
• če ste alergični na fosamprenavir, amprenavir ali katerokoli drugo sestavino tega zdravila
Patients aged 12 to 18 N=40 
Bolniki starosti 12 do 18 (leta) N=40
The potential for cross-sensitivity between medicinal products in the sulphonamide class and fosamprenavir is unknown. 
Možnost za navzkrižno občutljivost med zdravili v sulfonamidni skupini in fosamprenavirjem ni poznana.
Protease is an enzyme produced by HIV which enables the virus to multiply in white blood cells (CD4 cells) in your blood. 
Proteaza je encim virusa HIV, ki virusu omogoča razmnoževanje v belih krvnih celicah (celice CD4) v krvi.
Your dose of Telzir may need to be changed if you are taking • etravirine (used to treat HIV infection) 
Vaš odmerek zdravila Telzir bo morda potrebno spremeniti, če jemljete • etravirin (uporabljamo ga za zdravljenje okužb z virusom HIV)
Patients with renal impairment have not been specifically studied. 
Bolnikov z okvaro ledvic niso posebej preučevali.
• if their immune systems are very weak 
• ki imajo zelo oslabel imunski sistem.
Possible ↓ or ↑ of antithrombotic effect. 
Možno  ali  antitrombotičnega učinka.
All Patients, RD=F Analysis2 
Vsi bolniki, RD=F analiza n (%)
Patients aged 6 to 11 N=30 
Bolniki starosti 6 do 11 (leta) N=30
What you need to know before you take Telzir 
Kaj morate vedeti, preden boste vzeli zdravilo Telzir
Greater effects may be expected when fluticasone propionate is inhaled. 
Večji učinki so lahko pričakovani, če je flutikazon propionat inhaliran.
If you have moderate or severe liver disease the dose of Telzir has to be lowered. 
Če imate zmerno ali hudo bolezen jeter je potrebno odmerek zdravila Telzir znižati.
The MAH shall perform the required pharmacovigilance activities and interventions detailed in the agreed RMP presented in Module 1.8.2 of the Marketing Authorisation and any agreed subsequent updates of the RMP. 
Imetnik dovoljenja za promet z zdravilom bo izvedel zahtevane farmakovigilančne aktivnosti in ukrepe, podrobno opisane v,sprejetem RMP, predloženem v modulu 1.8.2 dovoljenja za promet z zdravilom, in vseh nadaljnjih posodobitvah RMP.
Amprenavir is a competitive inhibitor of the HIV-1 protease. 
Amprenavir je kompetitivni zaviralec proteaze virusa HIV-1.
It is not known whether amprenavir can be removed by peritoneal dialysis or haemodialysis. 
Ni znano, ali se lahko fosamprenavir odstrani s pomočjo peritonealne dialize ali hemodialize.
Pravastatin or fluvastatin are recommended because their metabolism is not dependent on CYP 3A4 and interactions are not expected with protease inhibitors. 
Priporočena sta pravastatin ali fluvastatin, ker njun metabolizem ne temelji na CYP 3A4 in interakcije s zaviralci proteaz niso pričakovane.
Renal clearance of ritonavir is also negligible, therefore the impact of renal impairment on amprenavir and ritonavir elimination should be minimal 
Ledvični očistek ritonavirja je prav tako zanemarljiv; torej je vpliv okvare ledvic na izločanje amprenavirja in ritonavirja minimalen.
ITT-E observed analysis 
ITT-E opazovana analiza
Osteonecrosis: cases of osteonecrosis have been reported, particularly in patients with generally acknowledged risk factors, advanced HIV disease or long-term exposure to CART. 
Osteonekroza: Opisani so bili primeri osteonekroze, še zlasti pri bolnikih s splošno znanimi dejavniki tveganja, napredovalo boleznijo HIV ali dolgotrajno izpostavljenostjo CART.
Pull out the syringe plunger until the first portion of your full dose is withdrawn. 
Izvlecite bat odmerne brizge dokler odmerne brizge ne napolnite s prvim delom vašega celotnega odmerka.
(Ritonavir 100 mg capsules twice daily for 7 days) 
(ritonavir 100 mg kapsule dvakrat dnevno 7 dni)
The mean AAUCMBs (log10 c/ml) in the ITT (E) population (Observed analysis) at 48 weeks (primary end-point) and other efficacy outcomes by subgroup are described in the tables below: 
Srednje vrednosti AAUCMB (log10 c/ml) v vključeni (izpostavljeni) populaciji (opazovana analiza) v 48 tednih (primarna končna točka) in drugi rezultati učinkovitosti po podskupini so predstavljeni v spodnjih preglednicah:
For any information about this medicinal product please contact the local representative of the Marketing Authorisation Holder. 
Za vse morebitne nadaljnje informacije o tem zdravilu se lahko obrnete na predstavništvo imetnika dovoljenja za promet z zdravilom:
People may be more likely to get this condition: 
Pojav tega stanja je verjetnejši pri bolnikih:
• Problems with your bones. 
• težave s kostmi.
Telzir oral suspension is the recommended option for the most accurate dosing in children based on body weight. 
Zdravilo Telzir peroralna suspenzija predstavlja priporočeno možnost za najbolj natančno odmerjanje pri otrocih glede na njihovo telesno maso.
The efficacy and safety of these therapies with fosamprenavir and ritonavir has not been established. 
Učinkovitost in varnost tovrstnih zdravljenj sočasno s fosamprenavirjem in ritonavirjem ni bila dokazana.
You will need extra check-ups, including blood tests, while you're taking your medication. 
Med zdravljenjem bodo potrebne dodatne preiskave, vključno s preiskavami krvi.
In rats exposed pre- and post-natally to fosamprenavir, pups showed impaired physical and functional development and reduced growth. 
Pri podganah, ko so bile pre- in postnatalno izpostavljene fosamprenavirju, so mladiči kazali okrnjen fizični in funkcionalni razvoj in zaostajanje v rasti.
No comparative studies have been undertaken in children or adolescents. 
Primerjalnih študij, ki bi vključevale otroke ali mladostnike, niso izvedli.
• doses of rifabutin greater than 150 mg every other day (an antibiotic) 
• rifabutin v odmerkih, večjih od 150 mg vsak drugi dan (antibiotik)
During attempts to overcome the decreased exposure by increasing the dose of other protease inhibitors with ritonavir, a high frequency of liver reactions was seen. 
Med poskusi, da bi presegli zmanjšano izpostavljenost s povečanjem odmerka drugih zaviralcev proteaze z ritonavirjem, so opazili večjo pogostnost jetrnih reakcij.
According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended. 
Skladno s zadnjimi smernicami za zdravljenje, se sočasna terapija s zaviralci proteaz na splošno ne priporoča.
Ritonavir induces CYP3A4, CYP1A2, CYP2C9 and glucuronosyl transferase. 
Ritonavir inducira CYP3A4, CYP1A2, CYP2C9 in glukuronozil transferazo.
If you forget to take Telzir 
Če ste pozabili vzeti zdravilo Telzir
See section ‘Other medicines and Telzir'. 
Glejte poglavje 'Druga zdravila in zdravilo Telzir'.
However, only 65 % of patients were receiving a PI based regimen at study entry. 
Vendar pa je ob vstopu v študijo zdravljenje le pri 65 % bolnikov temeljilo na PI.
Anticonvulsants (carbamazepine, phenobarbital) should be used with caution. 
Antiepileptike (karbamazepin, fenobarbital) je potrebno uporabljati previdno.
AAUCMB Observed Analysis 
Opazovana analiza AAUCMB
Co-administration of amprenavir with grapefruit juice was not associated with clinically significant changes in plasma amprenavir pharmacokinetics. 
Dajanje amprenavirja skupaj s sokom grenivke ni bilo povezano s klinično pomembnimi spremembami farmakokinetičnih lastnosti amprenavirja v plazmi.
Frequencies are defined as: Very common (≥ 1/10), Common (≥ 1/100 to < 1/10), Uncommon (≥ 1/1,000 to < 1/100), Rare (≥ 1/10,000 to < 1/1,000) or Very rare (< 1/10,000), or Not known. 
Pogostnost je navedena v skladu z naslednjim dogovorom: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do, < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000) in zelo redki (< 1/10.000), ali neznane pogostnosti.
It is recommended that phenytoin plasma concentrations be monitored and phenytoin dose increased as appropriate. 
Priporočeno je, da se kontrolirajo plazemske koncentracije fenitoina in da se po potrebi odmerek fenitotina poveča.
In some patients taking antiretroviral medicines including protease inhibitors, there have been reports of increased sugar in the blood and diabetes getting worse. 
Pri nekaterih bolnikih, ki so jemali protiretrovirusna zdravila, vključno z zaviralci proteaz, so poročali o zvišanju vrednosti krvnega sladkorja in poslabšanju sladkorne bolezni.
The effects of high fluticasone systemic exposure on ritonavir plasma levels are unknown. 
Učinki visoke sistemske izpostavljenosti flutikazonu na plazemske koncentracije ritonavirja so neznani.
Fluticasone propionate 50 µg intranasal 4 times daily) for 7 days 
flutikazon propionat 50 µg intranazalno 4-krat dnevno 7 dni
• lidocaine given by injection 
• lidokain v obliki injekcij
TRICYCLIC ANTIDEPRESSANTS 
TRICIKLIČNI ANTIDEPRESIVI
HIV can become resistant to anti-HIV medicines. 
Virus HIV lahko postane odporen na zdravila za zdravljenje okužbe z virusom HIV.
The inducing effect may persist for at least 2 weeks after cessation of treatment with St John's wort. 
Inducirajoči učinek lahko vztraja še najmanj 2 tedna po opustitvi zdravljenja s pripravki, ki vsebujejo šentjanževko.
It is recommended that HIV-infected women must not breast-feed under any circumstances to avoid transmission of HIV. 
Priporočljivo je, da ženske okužene z virusom HIV v nobenem primeru ne dojijo, saj s tem preprečijo prenos virusa HIV.
Adverse reactions are listed by MedDRA system organ class and absolute frequency. 
Neželeni učinki so navedeni v skladu z MedDRA klasifikacijo navajanja organskih sistemov in absolutne pogostnosti.
It is not known whether the ingredients in Telzir can also pass into your breast milk. 
Ni znano ali sestavine zdravila Telzir prehajajo v materino mleko.
2RD=F: Rebound or discontinuation equal failure analysis which is equivalent to TLOVR. 
2RD = F: Analiza "preobrat ali prenehanje, kar je enako neuspehu", in je enakovredno TLOVR.
If overdose occurs, the patient should be monitored for evidence of toxicity (see section 4.8) and standard supportive treatment applied as necessary. 
V primeru prevelikega odmerka je potrebno bolnika nadzirati glede znakov toksičnosti (glejte poglavje 4.8) in po potrebi zagotoviti običajno podporno terapijo.
The decrease in amprenavir AUC can result in virological failure and resistance development. 
Zmanjšanje AUC amprenavirja ima lahko za posledico virološko odpoved in razvoj rezistence.
Both of these studies compared fosamprenavir/ritonavir with lopinavir / ritonavir. 
Obe študiji sta primerjali kombinacijo fosmaprenavir/ritonavir s kombinacijo lopinavir/ritonavir.
This adjusted dose has not been evaluated in a clinical study and has been derived from extrapolation (see section 5.2). 
Ta prilagojeni odmerek ni bil ocenjen v klinični študiji, temveč je bil izpeljan na podlagi ekstrapolacije (glejte poglavje 5.2).
These data were further substantiated by the supportive study APV20003; however, a different dosage regimen than that of study APV29005 was used. 
Te podatke podpira tudi podporna študija APV20003, vendar pa je bil v tej študiji uporabljen drugačen režim odmerjanja kot v študiji APV29005.
Detailed information on this medicinal product is available on the website of the European Medicines Agency (EMA) http://www.ema.europa.eu 
Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila (EMA) http://www.ema.europa.eu/.
Amprenavir-related material was found in rat milk, but it is not known whether amprenavir is excreted in human milk. 
V podganjem mleku so zasledili amprenavirju sorodne snovi, vendar ni znano, ali se amprenavir izloča v materino mleko.
This is very important, as Telzir or ritonavir can strengthen or weaken the effects of other medicines. 
To je zelo pomembno, saj lahko zdravilo Telzir ali ritonavir okrepita ali oslabita učinek drugih zdravil, kar lahko včasih resno ogrozi zdravstveno stanje.
If you have any questions about this information or the advice given: →Talk to your doctor. 
Če imate kakršnokoli vprašanje o teh informacijah ali danih nasvetih: →Posvetujte se s svojim zdravnikom.
If you have any further questions about ritonavir or the other medicines prescribed, please ask your doctor or pharmacist. 
Če imate kakršnokoli dodatno vprašanje o uporabi ritonavirja ali drugih predpisanih zdravil, se posvetujte s svojim zdravnikom ali farmacevtom.
Elderly (over 65 years of age) 
Starostniki (starejši od 65 let)
When Telzir is co-administered with ritonavir, the half-life of amprenavir is increased to 15 - 23 hours. 
Če se zdravilo Telzir daje v kombinaciji z ritonavirjem, se razpolovni čas amprenavirja poveča na 15-23 ur.
Concomitant use is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects (see section 4.4). 
Sočasna uporaba ni priporočena, razen če možne koristi zdravljenja odtehtajo tveganje za sistemske učinke kortikosteroidov (glejte poglavje 4.4).
People with advanced HIV infection (AIDS) have weak immune systems and are more likely to develop serious infections (opportunistic infections). 
Bolniki z napredovalo okužbo z virusom HIV (AIDS) imajo oslabljen imunski sistem in so občutljivejši za pojav resnih okužb (oportunistične okužbe).
There have been reports of muscle pain, tenderness or weakness, particularly with antiretroviral therapy including protease inhibitors and nucleoside analogues. 
Poročali so o bolečinah v mišicah, občutljivosti ali šibkosti mišic, še posebej pri protiretrovirusnemu zdravljenju, ki je vključevalo zaviralce proteaz in nukleozidne analoge.
Efficacy outcomes by subgroups are described in the table below. 
Rezultati učinkovitosti po podskupinah so opisani v spodnji preglednici.
Fosamprenavir is a pro-drug of amprenavir and must not be administered concomitantly with other medicinal products containing amprenavir. 
Fosamprenavir je predzdravilo amprenavirja in se ne sme dajati sočasno z drugimi zdravili, ki vsebujejo amprenavir.
No dosing recommendations can be made for children weighing less than 25 kg. 
Za otroke, ki tehtajo manj kot 25 kg, ni mogoče dati priporočil za odmerjanje.
Most patients with mild or moderate rash can continue Telzir. 
Večina bolnikov z blagim ali zmernim kožnim izpuščajem lahko nadaljuje zdravljenje z zdravilom Telzir.
You may need additional factor VIII to control any bleeding. 
Za nadziranje krvavitev bo morda potrebno dodatno zdravljenje s faktorjem VIII.
This change will decrease the total active substance concentration in the plasma, however the amount of unbound amprenavir, which is the active moiety, is likely to be unchanged. 
Ta sprememba zmanjša skupno plazemsko koncentracijo zdravilne učinkovine, pri čemer količina aktivnega nevezanega amprenavirja verjetno ostane nespremenjena.
You need to know about important signs and symptoms to look out for while you're taking Telzir. 
Poznati morate pomembne znake in simptome in biti med zdravljenjem z zdravilom Telzir pozorni na njihov pojav.