natgillin/translations-raw huggingface dataset:
This dose may be adjusted, or treatment may be delayed depending on your blood cell counts and on your general condition. 
Ta odmerek lahko prilagodimo ali zdravljenje odložimo, odvisno od vašega števila krvnih celic ter vašega splošnega stanja.
Before each infusion you will have samples of your blood taken to evaluate if you have sufficient kidney and liver function and to check that you have enough blood cells to receive Pemetrexed Pfizer. 
Pred vsako infuzijo vam bomo odvzeli vzorce krvi za vrednotenje delovanja vaših ledvic in jeter ter oceno, ali imate dovolj krvnih celic za prejemanje zdravila Pemetreksed Pfizer.
The efficacy analyses using PQ population are consistent with the analyses for the ITT population and support the non-inferiority of AC versus GC. 
Analiza učinkovitosti z uporabo PK populacije je skladna z analizo NZ populacije in podpira prednost AC proti GC.
A total of 213 patients (48.3%) completed ≥ 6 cycles and a total of 103 patients (23.4%) completed ≥ 10 cycles of treatment with pemetrexed. 
Skupno 213 bolnikov (48,3 %) je zaključilo ≥ 6 ciklov in skupno 103 bolniki (23,4 %) so zaključili ≥ 10 ciklov zdravljenja s pemetreksedom.
Of the randomised patients, 44.9% had a complete/partial response and 51.9% had a response of stable disease to pemetrexed plus cisplatin induction. 
Izmed naključno izbranih bolnikov jih je 44,9 % doseglo popoln/delen odziv in 51,9 % jih je doseglo odziv stabilne bolezni na pemetreksed in indukcijsko zdravilo cisplatina.
At the time of this final survival analysis, 28.7% of patients were alive or lost to follow up on the pemetrexed arm versus 21.7% on the placebo arm. 
V času te končne analize preživetja je bilo živih ali ni bilo na voljo za nadaljnje spremljanje 28,7 % bolnikov v kraku pemetreksed v primerjavi z 21,7 % v kraku s placebom.
Pain, redness, swelling or sores in your mouth Nausea 
Bolečina, rdečina, otekanje ali rane v vaših ustih Slabost
Most of the patients in whom these events have been observed had pre-existing cardiovascular risk factors. 
Večina bolnikov, pri katerih so take dogodke opažali, je imela v preteklosti srčnožilne dejavnike tveganja.
Progression-free survival (months) 
Preživetje brez napredovanja (meseci)
If you would like to father a child during the treatment or in the 6 months following receipt of treatment, seek advice from your doctor or pharmacist. 
Če bi radi med zdravljenjem ali v 6 mesecih po zdravljenju spočeli otroka, se pogovorite s svojim zdravnikom ali farmacevtom.
Due to the increased thrombotic risk in patients with cancer, the use of anticoagulation treatment is frequent. 
Zaradi povečanega tveganja za trombozo pri bolnikih z rakavim obolenjem pogosto uporabljamo antikoagulacijsko zdravljenje.
A total of 169 patients (47.1%) completed ≥ 6 cycles maintenance treatment with pemetrexed, representing at least 10 total cycles of pemetrexed. 
Skupno je 169 bolnikov (47,1 %) zaključilo ≥ 6 ciklov vzdrževalnega zdravljenja s pemetreksedom, kar predstavlja vsaj 10 polnih ciklov pemetrekseda.
If you are also receiving cisplatin, your doctor will make sure that you are properly hydrated and receive appropriate treatment before and after receiving cisplatin to prevent vomiting. 
Če prejemate tudi cisplatin, bo zdravnik pred prejemanjem cisplatina in po njem preveril, ali ste ustrezno hidrirani ter da prejemate ustrezno zdravljenje za preprečevanje bruhanja.
This medicine is for single use only; any unused solution must be disposed of in accordance with local requirement. 
To zdravilo je namenjeno samo enkratni uporabi, morebitno neporabljeno raztopino je treba odstraniti v skladu z lokalnim predpisom.
Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu 
Podrobne informacije o tem zdravilu so dostopne na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu
Patients must also receive an intramuscular injection of vitamin B12 (1,000 micrograms) in the week preceding the first dose of pemetrexed and once every three cycles thereafter. 
Bolniki morajo prejeti tudi intramuskularno injekcijo vitamina B12 (1.000 mikrogramov) v tednu pred prvim odmerkom pemetrekseda in enkrat vsake tri cikluse zatem.
a Statistically significant for non-inferiority, with the entire confidence interval for HR well below the 1.17645 non-inferiority margin (p < 0.001). 
Statistično pomembna za prednost, s celotnim intervalom zaupanja za RT znatno pod 1,17645 mejo prednosti (p < 0,001).
Patients must receive adequate anti-emetic treatment and appropriate hydration prior to and/or after receiving cisplatin (see also cisplatin Summary of Product Characteristics for specific dosing advice). 
Bolniki morajo prejeti zadostno antiemetično zdravljenje, pred in/ali po prejemanju cisplatina jih moramo tudi ustrezno hidrirati (glejte tudi Povzetek glavnih značilnosti zdravila cisplatin za posebne nasvete o odmerjanju).
The risk is increased in subjects who are already immunosuppressed by their underlying disease. 
Tveganje je povečano pri ljudeh, ki imajo že zaradi svoje osnovne bolezni oslabljeno delovanje imunskega sistema.
In clinical studies, patients with creatinine clearance of ≥ 45 ml/min required no dose adjustments other than those recommended for all patients. 
V kliničnih študijah bolniki z očistkom kreatinina ≥ 45 ml/min niso potrebovali prilagajanja odmerkov, razen tistih prilagoditev, ki jih priporočamo za vse bolnike.
Results from in vitro studies with human liver microsomes indicated that pemetrexed would not be predicted to cause clinically significant inhibition of the metabolic clearance of medicinal products metabolised by CYP3A, CYP2D6, CYP2C9, and CYP1A2. 
Izsledki študij in vitro s človeškimi jetrnimi mikrosomi so pokazali, da za pemetreksed ne pričakujemo, da bi povzročil klinično pomembno zaviranje presnovnega očistka zdravil, ki se presnavljajo s CYP3A, CYP2D6, CYP2C9 in CYP1A2.
Myelosuppression is usually the dose-limiting toxicity. 
Mielosupresija običajno predstavlja toksičnost za omejitev odmerka.
Therefore, all patients treated with pemetrexed must be instructed to take folic acid and vitamin B12 as a prophylactic measure to reduce treatment-related toxicity (see section 4.2). 
Zato moramo vsem bolnikom, zdravljenim s pemetreksedom, naročiti, naj jemljejo folno kislino in vitamin B12 kot preprečevalni ukrep za zmanjšanje toksičnosti, povezane z zdravljenjem (glejte poglavje 4.2).
**In the pemetrexed /cisplatin arm, randomised and treated (N=225) and fully supplemented (N=167). 
**V veji zdravljenja s pemetreksed/cisplatinom, randomizirani in zdravljeni (N = 225) ter s popolnim dopolnjevanjem (N = 167).
The analysis of the impact of NSCLC histology on overall survival demonstrated clinically relevant differences in survival according to histology, see table below. 
Analiza vpliva histologije NSCLC na skupno preživetje je pokazala klinično ustrezne razlike v preživetju glede na histologijo, glejte preglednico spodaj.
Alkaline phosphatase (ALP), aspartate aminotransferase (AST or SGOT), and alanine aminotransferase (ALT or SGPT) should be ≤ 3-times upper limit of normal. 
Alkalna fosfataza (AF), aspartatna aminotransferaza (AST ali SGOT) in alaninska aminotransferaza (ALT ali SGPT) morajo biti ≤ 3-kratnik zgornje meje normalnih vrednosti.
Pemetrexed solutions are for single use only. 
Raztopine pemetrekseda so namenjene samo enkratni uporabi.
Pemetrexed is mainly eliminated unchanged renally by tubular secretion and to a lesser extent by glomerular filtration. 
Pemetreksed se izloča predvsem preko ledvic nespremenjen s tubulno sekrecijo in v manjšem obsegu z glomerulno filtracijo.
Very common 
Zelo Pogosto
Most of the patients in whom these events have been observed had preexisting cardiovascular risk factors (see section 4.8). 
Večina bolnikov, pri katerih so take dogodke opažali, je imela v preteklosti srčnožilne dejavnike tveganja (glejte poglavje 4.8).
Haemolytic anaemia (anaemia due to destruction of red blood cells) Hepatitis (inflammation of the liver) 
Hemolitična anemija (slabokrvnost zaradi propada rdečih krvnih celic) Hepatitis (vnetje jeter)
In the event of suspected overdose, patients should be monitored with blood counts and should receive supportive therapy as necessary. 
V primeru suma na preveliko odmerjanje moramo spremljati bolnikovo krvno sliko, po potrebi naj prejema podporno zdravljenje.
Extravasation should be managed by local standard practice as with other non-vesicants. 
Ob ekstravazaciji ukrepajte skladno z lokalno ustaljeno prakso kot pri drugih učinkovinah, ki niso mehurjevci.
• Fever or infection (common): if you have a temperature of 38ºC or greater, sweating or other signs of infection (since you might have less white blood cells than normal which is very common). 
• Povišana telesna temperatura ali okužba (pogosto): če se pojavi temperatura 38 ºC ali višja, znojenje ali drugi znaki okužbe (ker imate lahko manj belih krvničk kot normalno, kar je zelo pogosto).
If you have an accumulation of fluid around your lungs, your doctor may decide to remove the fluid before giving you Pemetrexed Pfizer. 
Če se vam okrog pljuč nabira tekočina, se bo zdravnik morda odločil tekočino pred dajanjem zdravila Pemetreksed Pfizer odstraniti.
It is a white to either light yellow or green-yellow lyophilised powder. 
Je bel do bodisi svetlo rumen bodisi zeleno-rumen liofiliziran prašek.
75% of previous dose 
75% predhodnega odmerka 75% predhodnega odmerka
**** Combined term includes increased serum/blood creatinine, decreased glomerular filtration rate, renal failure and renal/genitourinary- other. 
**** Skupni izraz vključuje povišan kreatinin v serumu/krvi, znižano stopnjo glomerulne filtracije, ledvično odpoved in ledvice/sečila - drugo.
Pemetrexed total systemic clearance is 91.8 ml/min and the elimination half-life from plasma is 3.5 hours in patients with normal renal function (creatinine clearance of 90 ml/min). 
Celotni sistemski očistek pemetrekseda je 91,8 ml/min, razpolovni čas izločanja iz plazme je 3,5 ur pri bolnikih z normalnim ledvičnim delovanjem (očistek kreatinina 90 ml/min).
A significant increase in the incidence of possibly study-medicinal product-related Grade 3/4 neutropenia was observed with longer exposure to pemetrexed (≤6 cycles: 3.3%, >6 cycles: 6.4%: p=0.046). 
Znatno povečanje pojavnosti nevtropenije stopnje 3/4, ki je lahko povezano s preučevanim zdravilom, so opazili pri dolgotrajnejši izpostavljenosti pemetreksedu (≤ 6 ciklov: 3,3 %, > 6 ciklov: 6,4 %: p=0,046).
Fatigue (tiredness) 
Utrujenost (izčrpanost)
Clinically relevant toxicities with respect to gender were similar to the overall population in patients receiving pemetrexed plus cisplatin. 
Klinično pomembne toksičnosti glede na spol so bile podobne v celotni populaciji pri bolnikih, ki so prejemali pemetreksed skupaj s cisplatinom.
The dose of Pemetrexed Pfizer is 500 milligrams for every square metre of your body's surface area. 
Odmerek zdravila Pemetreksed Pfizer je 500 miligramov za vsak kvadratni meter površine vašega telesa.
The primary analysis of this study was performed on the population of all patients randomly assigned to a treatment arm who received study drug (randomised and treated). 
Primarno analizo te študije so opravili na populaciji vseh bolnikov, ki so bili naključno dodeljeni v vejo zdravljenja, kjer so prejemali zdravilo v preskušanju (randomizirani in zdravljeni).
Pancytopenia- combined low counts of white cells, red cells and platelets Radiation pneumonitis (scarring of the air sacs of the lung associated with radiation therapy) may occur in patients who are also treated with radiation either before, during or after their pemetrexed therapy. 
Pancitopenija - skupno nizko število belih krvnih celic, rdečih krvnih celic in trombocitov Radiacijska pljučnica (brazgotinjenje pljučnih mešičkov, povezano z obsevanjem) se lahko pojavi pri bolnikih, ki so zdravljeni tudi z obsevanjem pred, med ali po zdravljenju s pemetreksedom.
Leucocytes decreased 17.8 Platelets decreased 
Znižani levkociti 17,8 Znižani trombociti
Creatinine elevation Creatinine clearance decreased** 
Povišan kreatinin 10,7 Znižan očistek kreatinina**
Each pack contains one glass vial of 100 mg, 500 mg or 1,000 mg pemetrexed. 
Vsako pakiranje vsebuje eno stekleno vialo s 100 mg, 500 mg ali 1.000 mg pemetrekseda.
Large cell (N = 153) 
Velike celice (N = 153)
Dose adjustments at the start of a subsequent cycle should be based on nadir haematologic counts or maximum non-haematologic toxicity from the preceding cycle of therapy. 
Prilagajanja odmerkov na začetku naslednjega ciklusa naj temeljijo na najnižjih hematoloških vrednostih ali na največji nehematološki toksičnosti iz predhodnega ciklusa zdravljenja.
Pemetrexed must only be administered under the supervision of a physician qualified in the use of anti-cancer chemotherapy. 
Pemetreksed smemo dajati le pod nadzorom zdravnika, usposobljenega za uporabo kemoterapije za zdravljenje raka.
Men are advised not to father a child during and up to 6 months following treatment with pemetrexed and should therefore use effective contraception during treatment with pemetrexed and for up to 6 months afterwards. 
Moškim odsvetujemo, da bi v času zdravljenja s pemetreksedom ter do 6 mesecev po zdravljenju s tem zdravilom spočeli otroka, zato naj v času zdravljenja s pemetreksedom ter do 6 mesecev po zdravljenju s tem zdravilom uporabljajo učinkovito kontracepcijo.
Store below 30°C 
Shranjujte pri temperaturi do 30 °C.
Thus, drainage of third-space fluid collection prior to pemetrexed treatment should be considered, but may not be necessary. 
Zato je pred zdravljenjem s pemetreskedom vredno premisliti o drenaži tekočine tretjega prostora, čeprav to morda ni potrebno.
* Refer to National Cancer Institute CTC version 2 for each grade of toxicity except the term “creatinine clearance decreased”. 
* Glejte CTC Nacionalnega inštituta za rakava obolenja, različico 2, za vsako stopnjo toksičnosti, razen izraza “znižan očistek kreatinina”.
Your doctor may decide to change the dose or delay treating you depending on your general condition and if your blood cell counts are too low. 
Zdravnik se bo morda odločil spremeniti odmerek ali odložiti zdravljenje, odvisno od vašega splošnega stanja, ter ob prenizkem številu krvnih celic.
A hospital pharmacist, nurse or doctor will have mixed the Pemetrexed Pfizer powder with water for injections and 5% glucose solution for injection before it is given to you. 
Bolnišnični farmacevt, medicinska sestra ali zdravnik bo prašek Pemetreksed Pfizer, preden ga boste prejeli, zmešal z vodo za injekcije in 5-odstotno raztopino glukoze za injiciranje.
Patients received a median of 5 cycles of maintenance treatment with pemetrexed and 3.5 cycles of placebo. 
Bolniki so dobili povprečno 5 ciklov vzdrževalnega zdravljenja s pemetreksedom in 3,5 cikle placeba.
All patients received study therapy as initial treatment for locally advanced or metastatic NSCLC and patients in both treatment groups were fully supplemented with folic acid and vitamin B12. 
Vsi bolniki so prejemali študijsko terapijo kot začetno zdravljenje za lokalno napredovali ali metastatski nedrobnocelični karcinom pljuč in bolniki v obeh skupinah zdravljenja so prejemali popolno dopolnilo s folno kislino in vitaminom B12.
• 95% CI for median 
• 95 % IZ za mediano
Treatment with pemetrexed should be discontinued if a patient experiences any haematologic or nonhaematologic Grade 3 or 4 toxicity after 2 dose reductions or immediately if Grade 3 or 4 neurotoxicity is observed. 
Zdravljenje spemetreksedom moramo prekiniti, če bolnik izkusi kakršnokoli hematološko ali nehematološko toksičnost stopnje 3 ali 4 po 2 znižanjih odmerka ali nemudoma, če opazimo nevrološko toksičnost stopnje 3 ali 4.
It must be administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle. 
Dajati ga je treba kot 10-minutno intravensko infuzijo prvi dan vsakega 21-dnevnega ciklusa.
Patients should be regularly monitored for acute tubular necrosis, decreased renal function and signs and symptoms of nephrogenic diabetes insipidus (e.g. hypernatraemia). 
Redno je treba spremljati, ali so se pri bolnikih pojavili akutna tubulna nekroza, zmanjšano delovanje ledvic ter znaki in simptomi nefrogenega diabetesa insipidusa (npr. hipernatriemija).
If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 
Če imate kakršna koli dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom ali s farmacevtom.
Pemetrexed is transported into cells by both the reduced folate carrier and membrane folate binding protein transport systems. 
Pemetreksed pride v celice s prenašalcem reduciranega folata in tudi preko membranskih transportnih sistemov folat vezavne beljakovine.
Preparation and administration precautions: As with other potentially toxic anti-cancer agents, care should be exercised in the handling and preparation of pemetrexed infusion solutions. 
Previdnostni ukrepi pri pripravi in dajanju: Kot pri drugih potencialno toksičnih učinkovinah za zdravljenje raka je potrebna previdnost pri ravnanju z raztopinami pemetrekseda za infundiranje ter pripravi teh raztopin.
CTC a Grade 
Stopnja CTC
Prior chemotherapy did not include pemetrexed. 
Predhodna kemoterapija ni vključevala pemetrekseda.
As a result, concomitant use of live attenuated vaccines is not recommended (see sections 4.3 and 4.5). 
Zato odsvetujemo uporabo živih oslabljenih cepiv (glejte poglavji 4.3 in 4.5).
Pemetrexed Pfizer is for intravenous use. 
Zdravilo Pemetreksed Pfizer je za intravensko uporabo.
The separation between the treatment arms was achieved by improvement in lung function in the pemetrexed /cisplatin arm and deterioration of lung function over time in the control arm. 
Razlikovanje med vejama zdravljenja je bilo doseženo z izboljšanjem delovanja pljuč v veji zdravljenja s pemetreksed/cisplatinom in poslabšanjem pljučnega delovanja s časom v kontrolni veji preskušanja.
Hypernatraemia - increased sodium in blood Inflammation of the skin, mainly of the lower limb with swelling, pain and redness 
Hipernatriemija - zvišana raven natrija v krvi Vnetje kože, večinoma spodnjih okončin, z otekanjem, bolečino in pordelostjo
If particulate matter is observed, do not administer. 
Če opazite trdne delce, te viale ne uporabite.
In a study conducted in beagle dog by intravenous bolus injection for 9 months, testicular findings (degeneration/necrosis of the seminiferous epithelium) have been observed. 
V 9-mesečni študiji, ki so jo izvedli na psih pasme beagle tako, da so jim dajali intravenske injekcije v bolusu, so opazovali spremembe na testisih (degeneracija/nekroza seminifernega epitelija).
Kidney: abnormal blood tests 
Ledvice: nenormalne vrednosti krvnih testov
An insufficient number of patients have been studied with creatinine clearance of below 45 ml/min. 
Zadostnega števila bolnikov z očistkom kreatinina pod 45 ml/min niso preučili.
If you currently have or have previously had problems with your kidneys, talk to your doctor or hospital pharmacist as you may not be able to receive Pemetrexed Pfizer. 
Če imate ali ste imeli težave z ledvicami, se pogovorite z zdravnikom ali bolnišničnim farmacevtom, ker morda ne boste mogli prejeti zdravila Pemetreksed Pfizer.
In vitro studies have shown that pemetrexed behaves as a multi-targeted antifolate by inhibiting thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotides. 
Študije in vitro so pokazale, da se pemetreksed vede kot večtarčni antifolat z zaviranjem timidilatne sintaze (TS), dihidrofolatne reduktaze (DHFR) in glicinamidne ribonukleotidne formiltransferaze (GARFT), ki so ključni od folata odvisni encimi za de novo biosintezo timidinskih in purinskih nukleotidov.
75% of previous dose (both pemetrexed and cisplatin) 
75 % predhodnega odmerka (obehpemetrekseda in cisplatina)
Therefore, the use of pemetrexed in patients with creatinine clearance of <45 ml/min is not recommended (see section 4.2). 
Zato uporabe pemetrekseda pri bolnikih z očistkom kreatinina < 45 ml/min ne priporočamo (glejte poglavje 4.2).
Infectious and non-infectious disorders of the dermis, the hypodermis and/or the subcutaneous tissue have been reported with an unknown frequency (e.g. acute bacterial dermo-hypodermitis, pseudocellulitis, dermatitis). 
Poročali so o nalezljivih in nenalezljivih boleznih dermisa, hipodermisa in/ali podkožja z neznano pogostnostjo (npr. akutni bakterijski dermohipodermitis, psevdocelulitis, dermatitis).
If patients develop non-haematologic toxicities ≥ Grade 3 (excluding neurotoxicity), pemetrexed should be withheld until resolution to less than or equal to the patient's pre-therapy value. 
Če se pri bolnikih razvijejo nehematološke toksičnosti ≥ stopnje 3 (z izjemo nevrološke toksičnosti), moramo dajanje pemetrekseda prekiniti, dokler se vrednosti ne povrnejo na manjše ali enake, kot jih je imel bolnik pred zdravljenjem.
Contact your doctor if you get a severe rash, or itching, or blistering (Stevens-Johnson syndrome or toxic epidermal necrolysis). 
Obvestite svojega zdravnika, če se pojavijo hud izpuščaj, srbenje ali mehurčki (Stevens-Johnsonov sindrom ali toksična epidermalna nekroliza).
Corticosteriods: your doctor will prescribe you steroid tablets (equivalent to 4 milligram of dexamethasone twice a day) that you will need to take on the day before, on the day of, and the day after Pemetrexed Pfizer treatment. 
Kortikosteroidi: vaš zdravnik vam bo predpisal tablete steroidov (ustrezno 4 miligramom deksametazona dvakrat dnevno), ki jih boste morali jemati dan pred zdravljenjem z zdravilom Pemetreksed Pfizer, na dan zdravljenja in na dan po zdravljenju z zdravilom Pemetreksed Pfizer.
The incidence of adverse reactions was evaluated for patients who received ≤6 cycles of pemetrexed maintenance (N=519), and compared to patients who received >6 cycles of pemetrexed (N=281). 
Pojavnost neželenih učinkov so ocenili za bolnike, ki so prejeli ≤ 6 ciklov vzdrževalnega zdravljenja s pemetreksedom (N=519) in jo primerjali z bolniki, ki so prejeli > 6 ciklov pemetrekseda (N=281).
Pre-treatment with dexamethasone (or equivalent) can reduce the incidence and severity of skin reactions (see section 
Predhodno zdravljenje z deksametazonom (ali drugim ustreznim kortikosteroidom) lahko zmanjša incidenco in resnost kožnih reakcij (glejte poglavje 4.2).
AST (SGOT) elevation 
SGOT (AST)
A subgroup analysis was performed on patients who received folic acid and vitamin B12 supplementation during the entire course of study therapy (fully supplemented). 
Analizo podskupin so opravili pri bolnikih, ki so prejemali dopolnilna folno kislino in vitamin B12 celoten čas trajanja zdravljenja v študiji (popolno dopolnjevanje).
Administration of pemetrexed to male mice resulted in reproductive toxicity characterised by reduced fertility rates and testicular atrophy. 
Dajanje pemetrekseda mišjim samcem je povzročilo reproduktivno toksičnost z nižjimi stopnjami plodnosti ter atrofijo testisov.
Cisplatin is also given by infusion into one of your veins, and is given approximately 30 minutes after the infusion of Pemetrexed Pfizer has finished. 
Cisplatin ravno tako dajemo v obliki infuzije v veno, približno 30 minut po zaključku infuzije zdravila Pemetreksed Pfizer.
If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with Pemetrexed Pfizer. 
Če ste bili nedavno cepljeni, prosimo, da o tem obvestite zdravnika, saj lahko to ob uporabi zdravila Pemetreksed Pfizer povzroča škodljive učinke.
Owing to the possibility of pemetrexed treatment causing irreversible infertility (see section 5.3), men are advised to seek counselling on sperm storage before starting treatment. 
Zaradi možnosti, da zdravljenje s pemetreksedom povzroči trajno neplodnost (glejte poglavje 5.3), naj se moški pred začetkom zdravljenja posvetujejo o shranjevanju sperme.
Blood clots in the lung blood vessels (pulmonary embolism) 
Krvni strdki v krvnih žilah v pljučih (pljučna embolija)
Rare cases of anaphylactic shock have been reported. 
Poročali so o redkih primerih anafilaktičnega šoka.