natgillin/translations-raw huggingface dataset:
EU/1/08/483/001 10 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/002 30 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/003 60 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/004 120 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/005 180 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/006 360 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/019 10 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/020 30 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/021 60 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/022 120 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/023 180 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/024 360 film-coated tablets (PCTFE/PVC/Alu) 
EU/1/08/483/001 10 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/002 30 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/003 60 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/004 120 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/005 180 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/006 360 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/019 10 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/020 30 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/021 60 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/022 120 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/023 180 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/024 360 filmsko obloženih tablet (PCTFE/PVC/Alu)
There may be an increased risk of angioedema in patients concomitantly taking ACE inhibitors. 
Kombinacija z zaviralci angiotenzinske konvertaze Pri bolnikih, ki sočasno jemljejo zaviralce angitenzinske konvertaze, je lahko prisotno povečano tveganje za angioedem (glejte poglavje 4.8).
EU/1/08/483/016 120 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/017 180 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/018 360 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/034 120 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/035 180 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/036 360 film-coated tablets (PCTFE/PVC/Alu) 
EU/1/08/483/016 120 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/017 180 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/018 360 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/034 120 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/035 180 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/036 360 filmsko obloženih tablet (PCTFE/PVC/Alu)
Skin disorders 
Kožne spremembe
EU/1/08/483/013 120 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/014 180 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/015 360 film-coated tablets (PA/Alu/PVC/Alu) EU/1/08/483/031 120 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/032 180 film-coated tablets (PCTFE/PVC/Alu) EU/1/08/483/033 360 film-coated tablets (PCTFE/PVC/Alu) 
EU/1/08/483/013 120 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/014 180 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/015 360 filmsko obloženih tablet (PA/Alu/PVC/Alu) EU/1/08/483/031 120 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/032 180 filmsko obloženih tablet (PCTFE/PVC/Alu) EU/1/08/483/033 360 filmsko obloženih tablet (PCTFE/PVC/Alu)
Oedema peripheral 
Žilne bolezni občasni periferni edemi
PARTICULARS TO APPEAR ON THE OUTER PACKAGING 
Izgled zdravila Zomarist in vsebina pakiranja
Diarrhoea, flatulence 
Bolezni živčevja pogosti omotičnost, tremor
Elimination Following oral administration of [ 
Izločanje Po peroralni aplikaciji s
Nervous system disorders Common 
Bolezni živčevja pogosti omotičnost občasni glavobol
- For patients inadequately controlled at their maximal tolerated dose of metformin monotherapy: The starting dose of Zomarist should provide vildagliptin as 50 mg twice daily (100 mg total daily dose) plus the dose of metformin already being taken. 
Z začetnim odmerkom zdravila Zomarist naj bolnik prejme po 50 mg vildagliptina dvakrat na dan (kar pomeni celotni dnevni odmerek 100 mg vildagliptina) in tolikšen odmerek metformina, kot ga je prejemal do tedaj.
Infections and infestations Very rare 
Bolezni prebavil pogosti navzea
Acute or chronic disease which may cause tissue hypoxia, such as: cardiac or respiratory failure, recent myocardial infarction, shock. 
Infekcijske in parazitske bolezni zelo redki okužba zgornjih dihal zelo redki nazofaringitis Presnovne in prehranske motnje občasni hipoglikemija
{Name and address} <{tel}> <{fax}> <{e-mail}> 
{Ime in naslov} <{tel.}> <{fax}> <{e-mail}>
A list of questions highlighting the issues to be discussed during this procedure was finalised on the 19th of March, 2008. 
Seznam vprašanj, ki izpostavlja zadržke, o katerih je treba razpravljati med tem postopkom, je bil dokončan dne 19. marca 2008.
Consequently, these 7 samples should have been excluded from the final calculation. 
Zaradi tega bi bilo treba teh sedem vzorcev izločiti iz končnih izračunov.
You may need to read it again 
Morda ga boste želeli ponovno prebrati.
This reduction remained until the conclusion of the study at week 24. 
To zmanjšanje se je ohranilo do konca študije v 24. tednu.
Treatment should be symptomatic. 
Zdravljenje mora biti simptomatsko.
Treatment should not be restarted until the woman is completely mobilised. 
Zdravljenja se ne sme znova začeti, dokler ni ženska povsem mobilizirana.
The presented frequencies should be interpreted in that light: 
Navedene pogostnosti je treba tolmačiti v tej luči:
These are not always serious, but they may need to be treated. 
Takšni strdki niso vedno resni, lahko pa zahtevajo zdravljenje.
Do not take a double dose to make up for a forgotten tablet. 
Ne vzemite dvojnega odmerka, da bi nadomestili pozabljeno tableto.
- KLIM/PD/11/USA study: 
- študija KLIM/PD/11/USA:
HRT may add to this risk. 
HNZ lahko prispeva k temu tveganju.
See a doctor as soon as possible. 
Čim prej pojdite k zdravniku.
Conditions which need supervision 
Stanja, ki zahtevajo nadzor
The occurrence of such an event is more likely in the first year of HRT than later. 
Takšni dogodki so verjetnejši v prvem letu HNZ kot pozneje.
The referral under article 29(4) of directive 2001/83/EC was notified to the CHMP on March 3rd, 2008 as Germany and France did not consider the application acceptable. 
Napotitveni postopek v skladu s členom 29(4) Direktive 2001/83/ES so pri CHMP prijavili dne 3. marca 2008, ker Nemčija in Francija vloge nista imeli za sprejemljivo.
B-1070 Brussel Belgium 
B-1070 Brussel Belgija
A-1010 Vienna Austria 
A-1010 Vienna Avstrija
Your doctor will tell you when you can start treatment again. 
Zdravnik vam bo povedal, kdaj spet lahko začnete z zdravljenjem.
This means that the doses of E2 and NETA are decreased by 50% and 80%, respectively. 
To pomeni, da sta odmerka E2 in NETA manjša za 50 % in 80 %.
Reasons for immediate withdrawal of therapy 
Razlogi za takojšnjo opustitev zdravljenja
For instructions on the use of the calendar pack, see “USER INSTRUCTIONS” at the end of the package leaflet. 
Za navodila za uporabo koledarskega pakiranja, glejte "NAVODILO ZA UPORABNICO" na koncu besedila.
• Probable dementia (For further information, see section 4.4) 
• verjetna demenca (za dodatne informacije glejte poglavje 4.4).
You may need to stop taking these tablets 4 to 6 weeks before the operation, to reduce the risk of a blood clot. 
Morda boste morali od 4 do 6 tednov pred operacijo nehati jemati te tablete, da boste zmanjšali tveganje za nastanek krvnega strdka.
It may harm them, even if their symptoms are the same as yours 
Njim bi lahko celo škodovalo, čeprav imajo znake bolezni, podobne vašim.
Free T4 and free T3 concentrations are unaltered. 
Koncentraciji prostega T4 in T3 se ne spremenita.
The half-life of 17β-estradiol is about 15 hours. 
Razpolovni čas 17β-estradiola je približno 15 ur.
The pharmacokinetics in the elderly has not been studied. 
Farmakokinetika pri starejših osebah ni raziskana.
Endometrial Safety 
Endometrijska varnost
Also go for regular health check, including mammography. 
Opravljajte tudi redne zdravstvene preglede, vključno z mamografijo.
Free or biological active hormone concentrations are unchanged. 
Koncentracije prostih ali biološko aktivnih hormonov se ne spremenijo.
(Invented) Name Strength 
Izmišljeno ime Jakost
The two issues discussed were as follows: 
V razpravi sta bila obravnavana naslednja dva zadržka:
Your doctor will tell you how often you should go for periodic check-ups, taking into account your general state of health. 
Zdravnik vam bo tudi povedal, kako pogosto morate prihajati na redne preglede; pri tem bo upošteval vaše splošno zdravstveno stanje.
According to calculations from the trial data, it is estimated that: 
Z izračuni na podlagi podatkov iz preskušanja ocenjujejo, da:
Tip out the next tablet. 
Iztresite naslednjo tableto.
• Difficulty breathing. 
• težko dihanje.
There is no evidence that HRT improves processes of remembering, learning and judging (cognitive function). 
Ni dokazov, da HNZ izboljšuje zmožnost za pomnjenje, učenje in presojanje (kognitivne funkcije).
The class “disordered proliferative” used in study KLIM/PD/7/USA is not well defined and not usually recognized. 
Razred „moteni proliferativni“, ki so ga uporabili v študiji KLIM/PD/7/USA, ni dobro definiran in se ga navadno ne priznava.
The absolute risks calculated from the MWS and the WHI trial are presented below: 
Absolutna tveganja, izračunana na podlagi preskušanj MWS in WHI, so prikazana spodaj:
• Migraine (see “Stop taking Activelle” in section 2) 
• migrena (glejte “Nehajte jemati zdravilo Activelle” v poglavju 2)
The MWS has estimated, from the known average incidence of breast cancer in developed countries, that: 
V preskušanju MWS so na podlagi znane povprečne incidence raka na dojki v razvitih državah ocenili, da:
Other factors that also increase the risk of stroke are: 
Drugi dejavniki, ki prav tako povečujejo tveganje za možgansko kap, so:
Post-marketing experience is subject to underreporting especially with regard to trivial and well known adverse drug reactions. 
Pomarketinške izkušnje so podvržene pomanjkljivemu prijavljanju, zlasti kar zadeva trivialne in dobro znane neželene reakcije na zdravilo.
Women should be advised what changes in their breasts should be reported to their doctor or nurse (see section below “Breast cancer”). 
Ženskam je treba povedati, o kakšnih spremembah na dojkah morajo obvestiti svojega zdravnika ali medicinsko sestro (glejte poglavje ''Rak na dojki'', spodaj).
If you need a blood test, tell your doctor that you are taking Activelle, since oestrogen can affect the results of certain laboratory tests. 
Če morate opraviti kakšno preiskavo krvi, zdravniku povejte, da jemljete zdravilo Activelle, kajti estrogen lahko vpliva na izvide nekaterih laboratorijskih preiskav.
Your doctor may then want to follow your treatment up more closely. 
Zdravnik bo morda natančneje spremljal vaše zdravljenje.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines including medicines obtained without a prescription, herbal medicines or other natural products. 
Obvestite svojega zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katero koli zdravilo; to velja tudi za zdravila, ki ste jih dobili brez recepta, za zdravila rastlinskega izvora in druge naravne izdelke.
It should be noted that sample size was very small (22 to 29 women), and no 95% confidence intervals for the incidence of hyperplasia are stated. 
Upoštevati je treba, da so bili vzorci zelo majhni (22 do 29 žensk) in da 95 % interval zaupanja za pojavnost hiperplazije ni bil naveden.
QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains: 
KAKOVOSTNA IN KOLIČINSKA SESTAVA Ena filmsko obložena tableta vsebuje:
There is no conclusive evidence for improvement of cognitive function. 
O izboljšanju kognitivne funkcije ni dokončnih dokazov.
• If bleeding carries on for more than the first few months 
• se krvavitve nadaljujejo več kot prvih nekaj mesecev,
The terminal half-life of NET is about 911 hours. 
Terminalni razpolovni čas NET je približno 9-11 ur.
Summary of CHMP Opinion 
Povzetek mnenja CHMP
Using other medicines Some medicines may reduce the effects of Activelle: 
Nekatera zdravila lahko zmanjšajo učinke zdravila Activelle:
• Depression or worsening of existing depression 
• depresija ali poslabšanje obstoječe depresije
To be able to detect a breast tumour as early as possible, it is important to regularly check your breasts for any changes and to discuss any changes with your doctor. 
Da bi tumor na dojki odkrili čim prej, je zelo pomembno, da si redno sami pregledujete dojke in se o vseh morebitnih spremembah posvetujete z zdravnikom.
OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF ACTIVELLE AND ASSOCIATED NAMES (SEE ANNEX I) 
SPLOŠNI POVZETEK ZNANSTVENEGA VREDNOTENJA ZDRAVILA ACTIVELLE IN Z NJIM POVEZANIH IMEN (GLEJTE DODATEK I)
Medicines should not be disposed of via waste water or household waste. 
Zdravila ne smete odvreči v odpadne vode ali med gospodinjske odpadke.
NET binds to SHBG (36%) and to albumin (61%). 
NET se veže na SHBG (36 %) in albumin (61 %).
If you have any close relative (mother, sister, maternal or paternal grandmother), who has suffered from serious illness, e.g. blood clot or breast cancer, you might also be at increased risk. 
Če imate bližnjo sorodnico (mamo, sestro, staro mamo po materini ali očetovi strani), ki je imela kakšno resno bolezen, npr. krvni strdek ali raka na dojki, ste tudi vi lahko bolj ogroženi.
The reporting rate of these spontaneous adverse drug reactions is very rare (<1/10,000 patient years). 
Delež prijav teh spontanih neželenih reakcij na zdravilo je zelo nizek (< 1/10.000 bolnic-let).
As in all postoperative patients, scrupulous attention should be given to prophylactic measures to prevent VTE following surgery. 
Tako kot pri vseh pooperacijskih bolnikih je treba posebno pozornost nameniti profilaktičnim ukrepom za preprečitev VTE po operacijah.
The experience of treating women older than 65 years is limited. 
Izkušnje z zdravljenjem žensk po 65. letu so omejene.
Before initiating or reinstituting HRT, a complete personal and family medical history should be taken. 
Pred začetkom ali ponovno uvedbo HNZ je treba vzeti popolno osebno in družinsko zdravstveno anamnezo.
A new combination should not induce a higher frequency of hyperplasia as compared to the recently authorised combinations. 
Nova kombinacija ne sme povzročiti večje pojavnosti hiperplazije kot nedavno odobrene kombinacije.
Remember to take only one tablet once a day. 
Jemljite samo eno tableto enkrat na dan.
Before you start taking Activelle, your doctor will inform you about the risks and benefits of the treatment (see also section 4, “Other side effects of combined HRT”). 
Pred začetkom jemanja zdravila Activelle vas bo zdravnik seznanil s tveganji in koristmi tega zdravljenja (glejte tudi poglavje 4, "Drugi neželeni učinki kombiniranega HNZ").
Relief of menopausal symptoms is achieved during the first few weeks of treatment. 
Olajšanje menopavznih simptomov se pokaže v prvih tednih zdravljenja.
ANNEX II SCIENTIFIC CONCLUSIONS AND GROUNDS PRESENTED BY THE EMEA 
DODATEK II ZNANSTVENI ZAKLJUČKI IN PODLAGA, KI JIH JE PREDSTAVILA EVROPSKA AGENCIJA ZA ZDRAVILA
Your doctor will explain the effects of stopping treatment and discuss other possibilities with you. 
Pojasnil vam bo, kakšni so učinki, če zdravilo nehate jemati, in se bo z vami pogovoril o drugih možnosti.
Investigations, including mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual. 
Preiskave, vključno z mamografijo, je treba opravljati v skladu z veljavno presejalno prakso in jih prilagoditi kliničnim potrebam posameznice.
• If you have epilepsy or asthma 
• če imate epilepsijo ali astmo,
It circulates bound to SHBG (37%) and to albumin (61%), while only approximately 1-2% is unbound. 
Kroži vezan na SHBG (37 %) in albumin (61 %); nevezanega je samo približno 1-2 %.
• If you have otosclerosis (hearing loss sometimes linked to pregnancy). 
• če imate otosklerozo (slabšanje sluha, včasih povezano z nosečnostjo).
Riverside Business Park Boulevard International BE-1070 Brussels Belgium 
Riverside Business Park Boulevard International BE-1070 Brussels Belgija pelliculés
• Drinking too much alcohol 
• čezmerno pitje alkoholnih pijač,
If the patient has forgotten to take a tablet, the tablet should be taken as soon as possible within the next twelve hours. 
Če bolnica pozabi vzeti tableto, jo mora vzeti čim prej v naslednjih dvanajstih urah.
The acute toxicity of estrogens is low. 
Akutna toksičnost estrogenov je majhna.
Bleeding and/or spotting appeared in 11 to 15% of the women during the first six months of treatment. 
Krvavitve in/ali krvavkast izcedek so se v prvih šestih mesecih zdravljenja pojavili pri 11 do 15 % žensk.
• Allergic reaction (hypersensitivity) 
• alergijska reakcija (preobčutljivost)
In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk. 
Pri vsaki bolnici je treba tveganja in koristi natančno oceniti vsaj enkrat na leto; HNZ se sme nadaljevati le, dokler koristi odtehtajo tveganja.
As well as regular check-ups with your doctor, be sure to: 
Poleg rednih pregledov pri zdravniku ne pozabite:
However, a majority of CHMP members endorsed the applicant/MAH's approach to provide a very low dose alternative of combined continuous HRT. 
Vendar pa je večina članov CHMP podprla pristop predlagatelja/imetnika dovoljenja za promet, ki je želel priskrbeti alternativen zelo nizek odmerek zdravila za kontinuirano kombinirano HNZ.
Before you start treatment and regularly during treatment, your doctor will evaluate whether Activelle is a suitable treatment for you. 
Pred začetkom zdravljenja in redno med zdravljenjem bo ocenil, ali je zdravilo Activelle (še) primerno za vas.
Therapy should be discontinued in case a contra-indication (see section 4.3) is discovered and in the following situations: 
Zdravljenje je treba prekiniti, če odkrijete kakšno kontraindikacijo (glejte poglavje 4.3) in v primeru:
The number of additional cases of breast cancer in women who use HRT is broadly similar for women who start HRT irrespective of age at start of use (between the ages of 45-65) (see section 4.4). 
Število dodatnih primerov raka na dojki pri ženskah, ki uporabljajo HNZ, je na splošno podobno pri ženskah, ki začnejo HNZ, ne glede na starost na začetku uporabe (v starosti od 45 do 65 let) (glejte poglavje 4.4).
How to take the first tablet Break the plastic tab and tip out the first tablet. 
Uporaba prve tablete Odlomite plastično zaporo in iztresite prvo tableto.
- The proportion of proliferative endometrium (71%) was higher, on the contrary the proportion of atrophic endometrium was lower (19%) than expected for a continuous combination. 
- Delež proliferacijskega endometrija (71 %) je bil večji, v nasprotju s tem pa je bil delež atropičnega endometrija nižji (19 %) od vrednosti, pričakovane za kombinacijo za kontinuirano uporabo.
Post marketing experience: 
Pomarketinške izkušnje
ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTH OF THE MEDICINAL PRODUCTS, ROUTE OF ADMINISTRATION, APPLICANTS / MARKETING AUTHORISATION HOLDER IN THE MEMBER STATES 
DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, PREDLAGATELJEV / IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
• If bleeding continues after stopping HRT. 
• se krvavitve nadaljujejo po prenehanju uporabe HNZ.
Your doctor should aim to prescribe the lowest dose for the shortest time that gives you relief from your symptoms. 
Zdravnik si mora prizadevati, da vam predpiše najnižji odmerek, ki zagotavlja ublažitev simptomov, za najkrajši čas.
The most important metabolites are isomers of 5α-dihydro-NET and of tetrahydro-NET, which are excreted mainly in the urine as sulfate or glucuronide conjugates. 
Najpomembnejši presnovki so izomeri 5α-dihidro-NET in tetrahidro-NET, ki se v glavnem izločijo v urinu kot sulfatni ali glukuronidni konjugati.
Using Activelle with food and drink The tablets can be taken with or without food and drink. 
Jemanje zdravila Activelle skupaj s hrano in pijačo Tableto lahko vzamete ne glede na obroke ali pijačo.
If you get breakthrough bleeding or spotting, it is usually nothing to worry about, especially during the first few months of taking HRT. 
Če se vam pojavi vmesna krvavitev ali krvavkast izcedek, to ponavadi ni razlog za skrb, še posebej ne v prvih mesecih uporabe HNZ.
Patients should be told to contact their doctors immediately when they are aware of a potential thromboembolic symptom (e.g. painful swelling of a leg, sudden pain in the chest, dyspnea). 
Bolnicam je treba naročiti, da se morajo takoj posvetovati z zdravnikom, če opazijo možne simptome trombembolije (npr. bolečo oteklost noge, nenadno bolečino v prsih, dispnejo).
Blood clots in the deep veins 
Krvni strdki v globokih venah
Stop taking HRT until your doctor says you can. 
Prenehajte jemati HNZ in ga ne uporabljajte, dokler vam zdravnik ne pove, da ga lahko.
For initiation and continuation of treatment of postmenopausal symptoms, the lowest effective dose for the shortest duration (see also section 4.4) should be used. 
Za uvedbo in nadaljevanje zdravljenja pomenopavznih simptomov je treba uporabiti najmanjši učinkoviti odmerek in ga uporabljati najkrajši možni čas (glejte tudi poglavje 4.4).
There was evidence of a higher incidence of hyperplasia when the progestogen was given every three months compared to when the progestogen was given sequentially every month. 
Prisotni so bili dokazi večje pojavnosti hiperplazije, če so progestogen dajali vsake tri mesece, v primerjavi z dajanjem progestogena sekvenčno vsak mesec.
The Cochrane review (Lethaby et al 2004) and analysis of available observational data (Anderson 2003, Beresford 97, Jain 2000, Hill 2000, Hully 98, MWS 2005, Newcomb 2003, Pike 97, Pukkala 2001, Weiderpass 99) suggest that addition of progestogen for at least 12 days per cycle reduces, but may not completely eliminate, the increased incidence of endometrial cancer caused by unopposed oestrogens; and that combined continuous HRT does not increase the risk of endometrial cancer. 
Pregled, ki ga je izvedel Cochrane (Lethaby et al 2004) in analiza razpoložljivih podatkov o opazovanjih (Anderson 2003, Beresford 97, Jain 2000, Hill 2000, Hully 98, MWS 2005, Newcomb 2003, Pike 97, Pukkala 2001, Weiderpass 99) nakazujejo, da dajanje progestogena vsaj 12 dni na cikel zmanjša, vendar ne odpravi v popolnosti povečane pojavnosti raka endometrija, ki ga povzročajo estrogeni, ki niso modificirani z učinki progestogena, in da kombinirano kontinuirano HNZ ne poveča tveganja raka endometrija.
You may start treatment with Activelle on any convenient day. 
Zdravljenje z zdravilom Activelle lahko začnete kateri koli dan, ki vam ustreza.
Activelle is prescribed for women who have not had their womb removed, and whose periods stopped more than a year ago. 
Zdravilo Activelle je namenjeno ženskam, ki jim maternica ni bila odstranjena in menstruacij nimajo že več kot eno leto.
• If you are allergic (hypersensitive) to estradiol, norethisterone acetate or any of the other ingredients of Activelle (listed in section 6,“Further information”). 
• ste alergični na (preobčutljivi za) estradiol, noretisteronacetat ali katero koli drugo sestavino zdravila Activelle (sestavine so naštete v poglavju 6, "Dodatne informacije"),
Conjugated oestrogens are excreted with the bile, where they are hydrolysed and reabsorbed (enterohepatic circulation), and mainly in urine in biologically inactive form. 
Konjugirani estrogeni se deloma izločijo v žolču, pri čemer se hidrolizirajo in reabsorbirajo (enterohepatični obtok), v glavnem pa v urinu v biološko neaktivni obliki.
On the next day simply move the transparent dial clockwise one space as indicated by the arrow. 
Naslednji dan preprosto premaknite prozorno kazalno ploščico v smeri urnega kazalca za en predalček, kot kaže puščica.