natgillin/translations-raw huggingface dataset:
Women should use an effective contraceptive method whilst taking Chenodeoxycholic acid Leadiant. 
Ženske morajo uporabljati učinkovito kontracepcijsko metodo, medtem ko jemljejo henodeoksiholno kislino.
The doctor should provide information on the dose to be received according to the weight of the child. 
Zdravnik mora zagotoviti informacije o prejetem odmerku, glede na telesno maso otroka.
In patients with CTX, no interaction studies with chenodeoxycholic acid and concomitantly administered medicinal products have been performed. 
Pri bolnikih z CTX niso izvedli nobenih študij medsebojnega delovanja s henodeoksiholno kislino in sočasno uporabljenimi zdravili.
It is recommended that this suspension is prepared by the pharmacy and instructions given to the parent on how to administer the suspension. 
Priporočljivo je, da suspenzijo pripravi farmacevt, ki staršem posreduje navodila o odmerjanju suspenzije.
Chenodeoxycholic acid has no or negligible influence on the ability to drive and use machines. 
Henodeoksiholna kislino nima ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
The starting dose in children is 5 mg/kg/day in three divided doses. 
Začetni odmerek pri otrocih je 5 mg/kg/dan v treh deljenih odmerkih.
In the pivotal study CDCA-STUK-15-001 treatment of CTX patients with chenodeoxycholic acid 7501000 mg/day in adults or 5-15 mg/kg/day in infants and children was associated with statistically significant decreases in mean serum levels of cholestanol from baseline to post-baseline in the overall population and in the two subgroups of patients aged < 21 years or ≥ 21 years at first treatment. 
V ključni študiji CDCA-STUK-15-001 je zdravljenje bolnikov s CTX z henodeoksiholno kislino z odmerkom 750-1000 mg/dan pri odraslih ali 5-15 mg/kg/dan pri dojenčkih in otrocih povezana s statistično pomembnim znižanjem povprečnega seruma holestanola od izhodišča do post-izhodišča v celotni populaciji in v dveh podskupinah bolnikov, starih <21 let ali ≥21 let na prvem zdravljenju.
Vitamin D and PTH levels decreased from baseline to both post-treatment visits and mean pyruvate levels decrease from baseline to the first post-treatment visit. 
Ravni vitamina D in koncentracije PTH so se zmanjšale od izhodišča pri obeh naknadnih obiskih po zdravljenju in povprečne ravni piruvata so se znižale od izhodišča pri prvem obisku po zdravljenju.
Chenodeoxycholic acid Leadiant should be used under medical supervision. 
Zdravilo Henodeoksiholinska kislina Leadiant je treba uporabljati pod zdravniškim nadzorom.
Chenodeoxycholic acid is not recommended during pregnancy and in women of childbearing potential not using contraception. 
Uporaba henodeoksiholne kisline ni priporočena med nosečnostjo in pri ženskah v rodni dobi, ki ne uporabljajo kontracepcije.
None of the patients had treatment-related adverse events and chenodeoxycholic acid exhibited a satisfactory safety profile in relation to routine safety laboratory parameters (haematology and clinical chemistry). 
Nobeden od bolnikov ni imel neželenih učinkov povezanih z zdravljenjem in henodeoksiholna kislina je imela zadovoljiv varnostni profil v povezavi z rutinskimi varnostnimi laboratorijskimi parametri
In contrast, Lithocholic acid sulfate conjugation in humans prevents the overt hepatotoxicity, as seen in animal toxicity species after repeat dosing. 
V nasprotju s tem konjugacija sulfata litoholne kisline pri ljudeh preprečuje očitno hepatotoksičnost, kot je razvidno iz vrste toksičnosti na živalih po zdravljenju.
The starting dose will be calculated at 5 mg per kg per day. 
Začetni odmerek se izračuna po 5 mg na kg na dan.
This instance of hepatic adverse reactions in an infant presented with multiple confounders, such as concomitant parechovirus infection, co-administration of medicinal products known to affect liver function (acyclovir and phenobarbital) and presence of hyperbilirubinemia at birth. 
Ta primer neželenih učinkov na jetra pri dojenčku je bil prisoten s številnimi motečimi dejavniki, kot so sočasna okužba s parehovirusom, sočasna uporaba zdravil, ki vplivajo na delovanje jeter (aciklovir in fenobarbital) in prisotnost hiperbilirubinemije ob rojstvu.
Whereas 7-keto-lithocholic acid can be formed partially in the colon and also in the liver to chenodeoxycholic acid and ursodeoxycholic acid (3α-, 7ß-di-hydroxycholanic acid), lithocholic acid is absorbed to a small extent only and is thus largely lost with faeces. 
Medtem ko se 7-keto litoholna kislina lahko v debelem črevesu in tudi v jetrih delno tvori v henodeoksiholno kislino in ursodeoksiholno kislino (3α-, 7β-di-hidroksiholanska kislina), se litoholna kislina absorbira le v majhni meri in se zato v veliki meri izgubi z blatom.
Ciclosporin and sirolimus 
Ciklosporin in sirolimus
After reabsorption in the intestine, the bile acid is nearly completely conjugated to the amino acids glycine and taurine and then excreted again in the bile. 
Po reabsorpciji v črevesju se žolčna kislina skoraj popolnoma združi v aminokislini glicin in tavrin in se nato ponovno izloči v žolč.
The mean levels of 7α-hydroxy-4-cholesten-3one significantly decreased from baseline to post-baseline Visits 1 and 2. 
Povprečne ravni 7α-hidroksi-4holesten-3-on so se bistveno znižale od izhodiščne vrednosti, po začetku študije pri naknadnem prvem in drugem obisku.
Oral contraceptives may affect the way in which Chenodeoxycholic acid Leadiant works making it less effective. 
Peroralni kontraceptivi lahko vplivajo na način delovanja zdravila Henodeoksiholna kislina Leadiant, zaradi česar je manj učinkovito.
Adverse reactions in patients (both adults and children) receiving Chenodeoxycholic acid are generally mild to moderate in severity; the main reactions observed are given in the table below. 
Povzetek varnostnega profila Neželeni učinki pri bolnikih (tako odrasli in otroci), ki so prejemali henodeoksiholno kislino so na splošno blagi do zmerni; glavni opaženi učinki so navedeni v spodnji preglednici.
For infants and children who cannot swallow capsules, the capsules may be carefully opened and the content added to sodium bicarbonate solution 8.4%, see section 6.6. 
Za dojenčke in otroke, ki ne morejo pogoltniti kapsul, lahko kapsule previdno odpremo in vsebino dodamo raztopini natrijevega bikarbonata 8,4%, glejte poglavje 6.6.
The infant's liver function normalised upon temporarily stopping treatment with Chenodeoxycholic acid. 
Delovanje jeter dojenčka se je normalizirajo po začasni prekinitvi zdravljenja z henodeoksiholno kislino.
Deconjugation results in the free bile acid, oxidation in the 7-keto-lithocholic acid and lithocholic acid (3α-hydroxycholanic acid) is formed by elimination of the 7-hydroxy group. 
Dekonjugacija vodi v prosto žolčno kislino, oksidacija v 7-keto-litoholno kislino in litoholna kislina (3α-hidroksiholanska kislina) se tvori z odcepitvijo 7-hidroksilne skupine.
Patients with a rare condition known as cerebrotendinous xanthomatosis (CTX) cannot produce chenodeoxycholic acid and this causes a buildup of fatty deposits in various areas of the body. 
Bolniki z redko motnjo, znano kot cerebrotendinoznaksantomatoza (CTX) ne morejo proizvesti henodeoksiholne kisline, kar povzroča kopičenje maščobnih oblog na različnih delih telesa.
If it is necessary to take a medicinal product containing one of these active substances it should be taken either 2 hours before or after taking chenodeoxycholic acid. 
Če morate vzeti zdravilo, ki vsebuje eno izmed teh učinkovin, jih je treba jemati bodisi 2 uri pred ali po jemanju henodeoksiholne kisline.
100 hard capsules 
100 trdih kapsul
Chenodeoxycholic acid is an endogenous bile acid used for replacement therapy and it is anticipated to have no effects on fertility at therapeutic doses. 
Henodeoksiholna kislina je endogena žolčna kislina, ki se uporablja za nadomestno zdravljenje in je pričakovati, da ne vpliva na plodnost pri terapevtskih odmerkih.
Rodent and primate toxicity species lack efficient-sulfating capacity for conjugation of lithocholic acid, and therefore have shown hepatotoxicity. 
Toksičnost za glodalce in primate ima premalo sulfatne zmogljivosti za konjugacijo litoholne kisline, zato se je pojavila hepatotoksičnost.
Capsule contents: maize starch, magnesium stearate, silica colloidal anhydrous, water, 
Vsebina kapsule: koruzni škrob, magnezijev stearat, koloidni brezvodni silicijev dioksid, , voda,
Ciclosporin has been shown to reduce the synthesis of chenodeoxycholic acid by inhibition of CYP27A1 and increasing the activity of HMG CoA reductase. 
Za ciklosporin je dokazano, da zmanjša sintezo henodeoksiholne kisline z inhibicijo CYP27A1 in poveča aktivnost HMG CoA reduktaze.
In rhesus monkey and baboon studies it was demonstrated that chenodeoxycholic acid dose to pregnant animals (at 5-120 mg/kg/day for rhesus monkey; at 18-38 mg/kg/day for baboons) produced liver pathology in the developing foetus. 
Študije z rezus opicami in pavijani so pokazale, da je odmerek henodeoksiholne kisline pri brejih živalih (pri odmerku 5-120 mg/kg/dan pri rezus opicah; pri odmerku 18-38 mg/kg/dan pri pavijanih) povzročil patologijo jeter pri razvijajočem zarodku.
Reduced production of cholesterol: reduces serum cholestanol (action on HMG CoA reductase). 
Manjša produkcija holesterola: zmanjša serum holestanol (učinek na HMG CoA reduktazo).
A pharmacy label should be placed on the bottle and include the patient's name, dosing instructions, use by date, name of medicinal product and any other required information to be in compliance with local pharmacy regulations. 
datum uporabe, ime zdravila, in vse druge potrebne informacije v skladu z lokalnimi predpisi v lekarni.
Chenodeoxycholic acid is indicated for the treatment of inborn errors of primary bile acid synthesis due to sterol 27 hydroxylase deficiency (presenting as cerebrotendinous xanthomatosis (CTX)) in infants, children and adolescents aged 1 month to 18 years and adults. 
Henodeoksiholna kislina je indicirana za zdravljenje prirojenih napak sinteze primarnih žolčnih kislin zaradi pomanjkanja sterol 27-hidroksilaze (se kaže kot cerebrotendinozna ksantomatoza (CTX)) pri dojenčkih, otrocih in mladostnikih, starih od 1 meseca do 18 let in odraslih.
The lowest dose of chenodeoxycholic acid that effectively reduces the serum cholestanol and/or urine bile alcohols levels to within the normal range should be chosen. 
Treba je izbrati najnižji odmerek henodeoksiholne kisline, ki učinkovito zmanjšuje ravni seruma holestanol in/ali ravni žolčnih alkoholov v urinu v mejah normale.
Reduced production of atypical bile alcohols and bile acids: through restoration of feedback inhibition of primary bile acid synthesis (action on CYP7A1) 
Manjša produkcija atipičnih žolčnih alkoholov in žolčnih kislin: z obnavljanjem povratne inhibicije primarne sinteze žolčne kisline (učinek na CYP7A1).
If your doctor considers it necessary for you to take ciclosporin, sirolimus or phenobarbital they will closely monitor the results of blood and urine tests and adjust the dose of Chenodeoxycholic acid Leadiant if necessary. 
Če zdravnik meni, da morate jemati ciklosporin, sirolimus ali fenobarbital, bo pozorno spremljal rezultate preiskav krvi in urina ter prilagodil odmerek henodeoksiholne kisline, če je potrebno.
In CTX, deficiency of chenodeoxycholic acid causes a lack of feedback of cholesterol 7 alpha hydroxylase (CYP7A1) and HMG CoA reductase, causing increased production of atypical bile acids, bile alcohols and cholestanol that lead to the pathological consequences of the condition. 
Pri CTX, pomanjkanje henodeoksiholne kisline povzroča premajhno odzivnost holesterola 7-alfa hidroksilaze (CYP7A1) in HMG Co A reduktaze, kar povzroča povečano produkcijo netipičnih žolčnih kislin, žolčnih alkoholov in holestanola, ki vodijo do patoloških posledic.
Oral contraceptives therefore may worsen the underlying deficiency and counteract the effectiveness of chenodeoxycholic acid in CTX. 
Peroralni kontraceptivi lahko zato poslabšajo prisotno pomanjkljivost in preprečijo učinkovitost henodeoksiholne kisline pri bolnikih s CTX.
MedDRA System Organ Class Preferred term 
MedDRA podatkovna baza glede na organske sisteme prednostni izraz pogostost
Urinary bile level alcohol levels decreased. 
Količina žolčnega alkohola v urinu se je znižala.
Increases in bone mineral density (Z-score) were observed at lumbar spine at both post-treatment visits and at total hip at post-treatment at post-treatment Visit 2. 
(Z-score) ledvene hrbtenice so opazili pri obeh obiskih po zdravljenju in v celotnem kolku po zdravljenju na drugem obisku.
Dose calculation (Children 1-12yr, adolescents 12-18yr and adults) chenodeoxycholic acid 10 mg/mL suspension 
Izračun odmerka (otroci 1-12 let, najstniki 12-18 let in odrasli) suspenzije henodeoksiholne kisline 10 mg/ml za bolnika
Two intrauterine deaths in a mother with CTX have been reported in the literature. 
Literatura navaja dve intrauterini smrti pri materah s CTX.
The pharmacy should provide oral dose syringes of appropriate volume and grading for administering the suspension. 
Lekarna vam mora zagotoviti brizge za peroralni odmerek z ustrezno prostornino in lestvico za odmerjanje suspenzije.
This being an approval under exceptional circumstances and pursuant to Article 14(8) of Regulation (EC) No 726/2004, the MAH shall conduct, within the stated timeframe, the following measures: 
726/2004, mora imetnik dovoljenja za promet v določenem časovnem okviru izvesti naslednje ukrepe:
Exogenous chenodeoxycholic acid is used as replacement therapy to restore the feedback inhibition lost due to the deficiency/absence of endogenous chenodeoxycholic acid. 
Eksogena henodeoksiholna kislina se uporablja za nadomestno zdravljenje za obnavljanje povratne inhibicije, do katere je prišlo zaradi pomanjkanja/odsotnosti endogenske henodeoksiholne kisline.
The maximum dose for children is 15 mg per kg per day. 
Največji odmerek za otroke je 15 mg na kg na dan.
Colestipol and antacid medicinal products 
Holestipol in antacidi
During the initiation of therapy and dose adjustment, serum cholestanol levels and/or urine bile alcohols should be monitored every 3 months till metabolic control and then annually. 
V začetku zdravljenja in po prilagoditvi odmerka je treba na vsake 3 mesece spremljati vrednosti seruma holestanola in/ali urina žolčnih alkoholov do presnovne urejenosti in nato vsako leto.
The dose range in children is 5-15 mg/kg per day. 
Razpon odmerka pri otrocih je 5-15 mg/kg na dan.
Concomitant administration of chenodeoxycholic acid with phenobarbital increases HMG CoA reductase and thus counteracts one of the pharmacodynamics effects of chenodeoxycholic acid in CTX. 
Sočasna uporaba henodeoksiholne kisline s fenobarbitalom povečuje HMG CoA reduktazo in s tem preprečuje enega od farmakodinamičnih učinkov henodeoksiholne kisline pri bolnikih s CTX.
No data are available for patients with hepatic impairment. 
Ni podatkov za bolnike z okvaro ledvic.
Chenodeoxycholic acid capsules can be taken without regards to food. 
Kapsule henodeoksiholne kisline se lahko jemljejo ne glede na hrano.
In CTX, a defect in the CYP27A1 gene results in a deficient mitochondrial sterol 27-hydroxylase enzyme. 
CTX napaka v genu CYP27A1 povzroča pomanjkanje mitohondrijskega encima sterol 27hidroksilaze.
In the intestine Chenodeoxycholic acid and its glycine or taurine conjugate are decomposed by bacteria. 
V črevesu se henodeoksiholna kislina in vezana glicin ali tavrin razgradita z bakterijami.
The primary pharmacodynamic effects of chenodeoxycholic acid are: 1. 
Primarni farmakodinamični učinki henodeoksiholne kisline so:
The following medicines may affect the levels of Chenodeoxycholic acid Leadiant: 
Naslednja zdravila lahko vplivajo na raven henodeoksiholne kisline:
Reduced production of cholestanol: reduces serum cholestanol (action on HMG CoA reductase and CYP7A1). 
Manjša produkcija holestanola: zmanjša serum holestanol (učinek na HMG CoA reduktazo in CYP7A1).
After treatment with chenodeoxycholic acid, the endogenous synthesis of the primary bile acids, cholic acid and chenodeoxycholic acid, is inhibited. 
Po zdravljenju z henodeoksiholno kislino se pojavi inhibicija endogenske sinteze primarnih žolčnih kislin, holne kisline in henodeoksiholne kisline.
Chenodeoxycholic acid is an endogenous bile acid in humans, which is tightly regulated by its secretion into bile via exporter pumps and detoxification by sulfation. 
Henodeoksiholna kislina je endogena žolčna kislina pri ljudeh, ki se tesno regulira z izločanjem v žolč preko črpalk in razstrupljanja s sulfatiranjem.
In two-non interventional studies with chenodeoxycholic acid, a total of 14 paediatric patients with CTX were treated with Chenodeoxycholic acid: 1 infant (0 to < 2 years), 6 children (2 to < 12 years) and 7 adolescents (12 to < 18 years). 
CTX zdravljenih s henodeoksiholno kislino: 1 otrok (0 do <2 leti), 6 otrok (2 do <12 let) in 7
A small portion of chenodeoxycholic acid is excreted with faeces. 
Majhen del henodeoksiholne kisline se izloči z blatom.
What you need to know before you take Chenodeoxycholic acid Leadiant 3. 
Kaj morate vedeti, preden boste vzeli zdravilo Henodeoksiholna kislina Leadiant 3.
It is not known if Chenodeoxycholic acid Leadiant passes into breast milk. 
Ni znano ali henodeoksiholna kislina prehaja v materino mleko.
Chenodeoxycholic acid should not be administered together with colestipol or antacid medicinal products containing aluminium hydroxide and/or smectite (aluminium oxide) since these preparations bind the active substance of chenodeoxycholic acid in the intestine and thus prevent its reabsorption and efficacy. 
Henodeoksiholne kisline se ne sme uporabljati skupaj s holestipolom ali antacidi, ki vsebujejo aluminijev hidroksid in/ali smektit (aluminijev oksid), saj ta zdravila vežejo henodeoksiholno kislino v črevesju in tako preprečijo resorpcijo in učinkovitost.
The total daily dose = 10 kg x 15 mg/kg = 150 mg 
Celotni dnevni odmerek = 10 kg x 15 mg/kg = 150 mg
What you need to know before you take Chenodeoxycholic acid Leadiant Do not take Chenodeoxycholic acid Leadiant 
Kaj morate vedeti, preden boste vzeli zdravilo Henodeoksiholna kislina Leadiant Ne jemljite zdravila Henodeoksiholna kislina Leadiant
Chenodeoxycholic acid Leadiant is not expected to affect your ability to drive or use machines. 
Henodeoksiholna kislina naj ne bi vplivala na vašo sposobnost vožnje ali upravljanja s stroji.
Co-administration of chenodeoxycholic acid with ciclosporin or sirolimus should be avoided. 
Izogniti se je treba sočasni uporabi henodeoksiholne kisline s ciklosporinom ali sirolimusom.
What Chenodeoxycholic acid Leadiant is and what it is used for 2. 
Kaj je zdravilo Henodeoksiholna kislina Leadiant in za kaj ga uporabljamo 2.
After the initiation period, cholestanol, urine bile alcohols and liver function should be determined annually, at a minimum, and the dose adjusted accordingly. 
Po začetnem obdobju je treba holestanol, žolčne alkohole v urinu in delovanje jeter preverjati najmanj letno in odmerek ustrezno prilagoditi.
Constipation not known 
Bolezni prebavil zaprtje ni znano
Chenodeoxycholic acid should not be administered together with colestyramine as it binds chenodeoxycholic acid in the intestine and thus prevents its reabsorption and efficacy. 
Henodeoksiholne kisline se ne sme uporabljati skupaj z holestiraminom, saj veže henodeoksiholno kislino v črevesju in tako preprečuje njeno reabsorpcijo in učinkovitost.
Pathological effects on adrenals and kidneys were also seen in rhesus monkey foetuses. 
Pri zarodkih rezus opice so opazili tudi patološke učinke na nadledvične žleze in ledvice.
Two pregnancies in mothers with CTX resulted in premature infants with evidence of intrauterine growth retardation also reported in the literature. 
Literatura navaja dve nosečnosti pri materah s CTX, ki sta imeli za posledico nedonošenčka z znaki intrauterinega zaostajanja rasti.
Chenodeoxycholic acid Leadiant capsules contain a substance called chenodeoxycholic acid. 
Kapsule zdravila Henodeoksiholna kislina Leadiant vsebujejo snov, imenovano henodeoksiholna kislina.
Chenodeoxycholic acid Leadiant capsules treats CTX by replacing the chenodeoxycholic acid, which prevents the build-up of the fatty deposits. 
Kapsule zdravila Henodeoksiholna kislina Leadiant zdravijo CTX z zamenjavo henodeoksiholne kisline, ki preprečuje kopičenje maščobnih oblog.
Chenodeoxycholic acid Leadiant is unlikely to cause serious side effects. 
Zdravilo Henodeoksiholna kislina Leadiant običajno ne povzroči resnih neželenih učinkov.
The divided dose when given three times a day = 15 mg = 5 mg 
Razdeljen odmerek pri dajanju trikrat na dan = 15 mg = 5 mg
The active substance will be dissolved in the sodium bicarbonate solution and as not all the contents of the capsule will be dissolved it appears as a mixture. 
Celotna vsebina kapsule se ne bo raztopila, zaradi česar bo videti kot mešanica.
Package leaflet: Information for the user Chenodeoxycholic acid Leadiant 250 mg hard capsules chenodeoxycholic acid This medicine is subject to additional monitoring. 
Navodilo za uporabo Henodeoksiholna kislina Leadiant 250 mg trde kapsule henodeoksiholna kislina Za to zdravilo se izvaja dodatno spremljanje varnosti.
Elderly patients (≥ 65 years) 
Posebne skupine bolnikov Starejši bolniki (≥ 65 let) Prilagajanje odmerka ni potrebno.
Where the dose calculated is not a multiple of 250 mg, the nearest dose below the maximum of 15 mg/kg/day should be selected, provided that is sufficient to normalise serum cholestanol and/or urine bile alcohols. 
Kjer izračunan odmerek ni večkratnik 250 mg, je treba izbrati najbližji odmerek, manjši od največ 15 mg/kg/dan, pod pogojem,
The divided dose when given three times a day = 150 mg = 50 mg 
Razdeljen odmerek pri dajanju trikrat na dan = 150 mg = 50 mg
It is not recommended to take Chenodeoxycholic acid Leadiant during pregnancy and breast-feeding. 
Jemanje henodeoksiholne kisline med nosečnostjo in dojenjem ni priporočljivo.
The net result is a total bile acid pool that is severely deficient in chenodeoxycholic acid but relatively enriched with cholic acid. 
Skupni rezultat je zbir čiste žolčne kisline s hudim pomanjkanjem henodeoksiholne kisline, vendar z veliko holne kisline.
For babies, children and those who cannot swallow capsules and/or need to take a dose below 250 mg, a capsule may be opened and the contents mixed with 8.4% sodium bicarbonate solution. 
Za dojenčke, otroke in tiste, ki ne morejo pogoltniti kapsule in/ali morajo vzeti odmerek pod 250 mg lahko kapsule odprete in vsebino zmešate z raztopino 8,4 % natrijevega bikarbonata.
Dose calculation (Infants 1month-1yr) chenodeoxycholic acid 5 mg/mL suspension Daily dose: 
Izračun odmerka (otroci 1 mesec-1 leto) suspenzije henodeoksiholne kisline 5 mg/ml za bolnika Dnevni odmerek:
One instance of mild intermittent constipation occurred in an adult and another instance occurred in a child. One instance of hepatic adverse reactions occurred in a two week old infant diagnosed with CTX and is discussed in the section below. 
En primer neželenih učinkov na jetra se je pojavil pri dvotedenskem dojenčku z diagnozo CTX in je obravnavan v nadaljevanju.
Exogenous replacement with Chenodeoxycholic acid inhibits CYP7A1 (via nuclear receptor, FXR) and HMG CoA reductase, thus restoring the feedback inhibition. 
Eksogena zamenjava s henodeoksiholno kislino inhibira CYP7A1 (prek jedrskega receptorja, FXR) in HMG CoA
What Chenodeoxycholic acid Leadiant is and what it is used for 
Kaj je zdravilo Henodeoksiholna kislina Leadiant in za kaj ga uporabljamo
Chenodeoxycholic acid Leadiant 250 mg hard capsules 
Henodeoksiholna kislina Leadiant 250 mg trde kapsule
The administration of oral contraceptives reduces the pool size of chenodeoxycholic acid. 
Dajanje peroralnih kontraceptivov zmanjša velikost vzorcev henodeoksiholne kisline.
10 kg patient on a dose of 15 mg/kg of chenodeoxycholic acid. 
Bolnik z maso 10 kg za odmerek 15 mg/kg henodeoksiholne kisline.
3 kg patient on a dose of 5 mg/kg of chenodeoxycholic acid. 
Bolnik z maso 3 kg za odmerek 5 mg/kg henodeoksiholne kisline.
Chenodeoxycholic acid should be taken either one hour before cholestyramine or 4-6 hours after. 
morate vzeti henodeoksiholno kislino eno uro pred holestiraminom ali 4-6 ur kasneje.