natgillin/translations-raw huggingface dataset:
Due to the hydrochlorothiazide contained in Irbesartan/Hydrochlorothiazide Teva, if you drink alcohol while on treatment with this medicine, you may have an increased feeling of dizziness on standing up, specially when getting up from a sitting position. 
Če med zdravljenjem z zdravilom Irbesartan/hidroklorotiazid Teva uživate alkoholne pijače, lahko hidroklorotiazid, ki ga vsebuje zdravilo Irbesartan/hidroklorotiazid Teva, povzroči omotico v stoječem položaju, še posebej po vstajanju iz sedečega položaja.
As for any combination of two active substances, side effects associated with each individual component cannot be excluded. 
V vsakem kombiniranem zdravilu lahko neželene učinke povzroči vsaka od učinkovin, ki jih zdravilo vsebuje.
The use of Irbesartan/Hydrochlorothiazide Teva during breast feeding is not recommended. 
Uporaba zdravila Irbesartan/hidroklrotiazid Teva med dojenjem ni priporočljiva.
Irbesartan/Hydrochlorothiazide Teva 150 mg/12.5 mg film-coated tablets Irbesartan/Hydrochlorothiazide Teva 300 mg/12.5 mg film-coated tablets Irbesartan/Hydrochlorothiazide Teva 300 mg/25 mg film-coated tablets 
Irbesartan/hidroklorotiazid Teva 150 mg/12,5 mg filmsko obložene tablete Irbesartan/hidroklorotiazid Teva 300 mg/12,5 mg filmsko obložene tablete Irbesartan/hidroklorotiazid Teva 300 mg/25 mg filmsko obložene tablete
Blood and lymphatic system disorders: 
Bolezni krvi in limfatičnega sistema neznana trombocitopenija
Pharmacotherapeutic group: angiotensin-II antagonists, combinations ATC code: C09D A04 
Farmakoterapevtska skupina: antagonisti angiotenzina II, kombinacije
The administration of a non-steroidal anti-inflammatory drug may reduce the diuretic, natriuretic and antihypertensive effects of thiazide diuretics in some patients; 
Pri nekaterih bolnikih se lahko med hkratnim jemanjem nesteroidnih protivnetnih zdravil zmanjša diuretski, natriuretski in antihipertenzijski učinek tiazidnih diuretikov.
Pack size of 50x1 film coated tablet in unit dose blisters. 
Perforirani pretisni omot z enkratnimi odmerki po 50x1 filmsko obloženo tableto.
(95% CI: 1.23-1.35) for BCC and 3.98 (95% CI: 3.68-4.31) for SCC. 
Veliki odmerki hidroklorotiazida (kumulativno ≥ 50.000 mg) so bili povezani s prilagojenim razmerjem obetov (OR) 1,29 (95-odstotni IZ: 1,23-1,35) za bazalnocelični karcinom in 3,98 (95-odstotni IZ: 3,68-4,31) za ploščatocelični karcinom.
Transient blurred vision, xanthopsia, acute myopia and secondary acute angle-closure glaucoma 
Očesne bolezni neznana prehodno zamegljen vid, ksantopsija, akutna kratkovidnost in sekundarni akutni glavkom z zaprtim zakotjem
In non clinical safety studies, high doses of irbesartan (≥ 250 mg/kg/day in rats and ≥ 100 mg/kg/day in macaques) 
V predkliničnih varnostnih študijah so veliki odmerki irbesartana (≥ 250 mg/kg/dan pri podganah in ≥ 100 mg/kg/dan pri opicah) povzročili zmanjšanje parametrov rdečih krvnih celic (eritrociti, hemoglobin, hematokrit).
Irbesartan/Hydrochlorothiazide Teva will usually be prescribed by your doctor when your previous treatment for high blood pressure did not provide appropriate blood pressure reduction. 
Zdravnik vam je zdravilo Irbesartan/hidroklorotiazid Teva predpisal zato, ker se med dosedanjim zdravljenjem zvišanega krvnega tlaka ta ni dovolj znižal.
Colestyramine and Colestipol resins 
Holestiramin in holestipol
If you accidentally miss a daily dose, just take the next dose as normal. 
Če ste pozabili vzeti zdravilo Irbesartan/hidroklorotiazid Teva Če ste pozabili vzeti dnevni odmerek, vzemite le naslednji predvideni odmerek ob običajnem času.
Adverse reactions reported with the use of irbesartan alone General disorders and administration site conditions: 
Neželeni učinki, o katerih so poročali pri uporabi irbesartana samega Splošne težave in spremembe na mestu aplikacije občasni bolečina v prsnem košu
Although equivocal evidence for a genotoxic or carcinogenic effect was found in some experimental models, the extensive human experience with hydrochlorothiazide has failed to show an association between its use and an increase in neoplasms. 
Na nekaj eksperimentalnih modelih so opazili genotoksično in karcinogeno delovanje hidroklorotiazida, vendar pa dokazi niso zanesljivi.
Undesirable effects where the frequency is not known are: headache, ringing in the ears, cough, taste disturbance, indigestion, pain in joints and muscles, liver function abnormal and impaired kidney function, increased level of potassium in your blood and allergic reactions such as rash, hives, swelling of the face, lips, mouth, tongue or throat. 
Neželeni učinki, katerih pogostnost ni znana, so: glavobol, zvonenje v ušesih, kašelj, motnje okušanja, prebavne motnje, bolečine v sklepih in mišicah,
Antidiabetic medicinal products (oral agents and insulins) Dosage adjustment of the antidiabetic medicinal product may be required (see section 4.4); 
Morda bo treba prilagoditi odmerek antidiabetika (glejte poglavje 4.4).
Drug substance 
SEZNAM POMOŽNIH SNOVI
Irbesartan/Hydrochlorothiazide Teva 150 mg/12.5 mg 
Irbesartan/hidroklorotiazid Teva 150 mg/12,5 mg
Valsartan 
ŠKATLA
When measured by ambulatory blood pressure monitoring, the trough to peak effects of irbesartan/hydrochlorothiazide 150 mg/12.5 mg were 100 %. 
Med 24-urnim merjenjem krvnega tlaka pri bolnikih, ki so prejemali kombinacijo irbesartana in hidroklorotiazida 150 mg/12,5 mg, je bilo razmerje med najmanjšim in največjim učinkom 100 %.
The degree to which hydrochlorothiazide is removed by haemodialysis has not been established. 
Koliko hidroklorotiazida se izloči s hemodializo,
The combination of irbesartan and hydrochlorothiazide has been rarely associated with symptomatic hypotension in hypertensive patients without other risk factors for hypotension. 
Simptomatska hipotenzija se pri bolnikih z zvišanim krvnim tlakom, ki jemljejo kombinacijo irbesartana in hidroklorotiazida, nimajo pa drugih dejavnikov tveganja za hipotenzijo, pojavi le redko.
Given their similar pharmacodynamic properties, these results are also relevant for other ACE- inhibitors and angiotensin II receptor blockers. 
Ti izsledki so pomembni tudi za druge zaviralce ACE in blokatorje receptorjev angiotenzina II, ker so njihove farmakodinamične lastnosti podobne.
In clinical studies, the pharmacokinetic of irbesartan is not affected by hydrochlorothiazide. 
Dodatni podatki o medsebojnem delovanju z irbesartanom V kliničnih študijah hidroklorotiazid ni vplival na farmakokinetiko irbesartana.
Syncope, hypotension, tachycardia, oedema 
Srčne bolezni občasni sinkopa, hipotenzija, tahikardija edem
There is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists. 
Pri bolnikih z obojestransko zožitvijo ledvičnih arterij ali zožitvijo arterije delujoče ledvice se med jemanjem zaviralcev angiotenzinske konvertaze ali antagonistov angiotenzina II zveča nevarnost pojava hude hipotenzije in motnje v ledvičnem delovanju.
There were 0.6 % and 0 % of patients with hypotension and 2.8 % and 3.1 % of patients with dizziness as adverse reactions reported in the combination and monotherapy groups, respectively. 
V skupini, ki je prejemala kombinacijo učinkovin so pri 0,6 % bolnikov poročali o pojavu hipotenzije in pri 2,8 % bolnikov o pojavu omotice.
Adequate monitoring of serum potassium in patients at risk is recommended. 
Pri ogroženih bolnikih je priporočeno spremljanje serumske vrednosti kalija.
Irbesartan/Hydrochlorothiazide Teva 300 mg/12.5 mg 
Irbesartan/hidroklorotiazid Teva 300 mg/12,5 mg
Rare cases of allergic skin reactions (rash, urticaria), as well as localised swelling of the face, lips and/or tongue have been reported in patients taking irbesartan. 
koprivnica) in lokaliziranih oteklinah obraza, ustnic in/ali jezika.
Increases in blood urea nitrogen (BUN), creatinine and creatine kinase Decreases in serum potassium and sodium 
kreatinina in kreatin-kinaze občasni znižanje vrednosti serumskega kalija in natrija
Unless continued AIIRAs therapy is considered essential, patients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancy. 
Pri bolnicah, ki načrtujejo nosečnost, je treba čim prej preiti na alternativno antihipertenzivno zdravljenje z uveljavljenim varnostnim profilom za uporabo v nosečnosti; razen če se oceni, da je nadaljnje zdravljenje z antagonisti angiotenzina II nujno.
Irbesartan/Hydrochlorothiazide Teva is unlikely to affect your ability to drive or use machines. 
Možnost, da bi zdravilo Irbesartan/hidroklorotiazid Teva vplivalo na sposobnost za upravljanje vozil in strojev je majhna.
Thiazides may increase the risk of adverse effects caused by amantadine. 
Zaradi uporabe tiazidnih diuretikov se zveča nevarnost pojava neželenih učinkov amantadina.
Based on its pharmacodynamic properties, Irbesartan/Hydrochlorothiazide Teva is unlikely to affect the ability to drive and use machines. 
4.7 Vpliv na sposobnost vožnje in upravljanja s stroji Na osnovi farmakodinamičnih lastnosti je malo verjetno, da bi zdravilo Irbesartan/hidroklorotiazid Teva vplivalo na sposobnost vožnje in upravljanja s stroji.
Respiratory distress (including pneumonitis and pulmonary oedema) 
Bolezni dihal, prsnega koša in mediastinalnega prostora neznana respiratorni distres (vključno s pljučnico in pljučnim edemom)
Each film-coated tablet contains 300 mg irbesartan and 25 mg hydrochlorothiazide 
Vsaka filmsko obložena tableta vsebuje 300 mg irbesartana in 25 mg hidroklorotiazida.
if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren. 
če imate hudo okvaro jeter ali ledvic če imate težave z odvajanjem seča če je zdravnik ugotovil, da imate stalno zvečano koncentracijo kalcija ali zmanjšano koncentracijo kalija v krvi če imate sladkorno bolezen ali okvarjeno delovanje ledvic in se zdravite z zdravilom za znižanje krvnega tlaka, ki vsebuje aliskiren
Thiazide diuretics may increase serum calcium levels due to decreased excretion. 
Tiazidni diuretiki lahko zmanjšajo izločanje kalcija in tako zvišajo njegovo serumsko koncentracijo.
Co-administration of thiazide diuretics may increase the incidence of hypersensitivity reactions to allopurinol; 
Med sočasnim zdravljenjem s tiazidnimi diuretiki so lahko preobčutljivostne reakcije na alopurinol pogostejše.
DATE OF REVISION OF THE TEXT 
DATUM PRIDOBITVE DOVOLJENJA ZA PROMET Z ZDRAVILOM
Furthermore, irbesartan induced hyperplasia/hypertrophy of the juxtaglomerular cells (in rats at ≥ 90 mg/kg/day, in macaques at ≥ 10 mg/kg/day). 
Irbesartan je povzročil hiperplazijo/hipertrofijo jukstaglomerulnih celic (pri podganah po odmerku ≥
Pancreatitis, anorexia, diarrhoea, constipation, gastric irritation, sialadenitis, loss of appetite 
draženje želodca, vnetje žleze slinavke, izguba apetita
Irbesartan/Hydrochlorothiazide Teva 300 mg/25 mg film-coated tablets are pink to dark pink, film coated capsule shaped tablet. 
Irbesartan/hidroklorotiazid Teva 300 mg/25 mg filmsko obložene tablete so rožnate do temno rožnate filmsko obložene tablete v obliki kapsul.
Aplastic anaemia, bone marrow depression, neutopenia/agranulocytosis, haemolytic anaemia, leucopenia, thrombocytopenia 
Bolezni krvi in limfatičnega sistema neznana aplastična anemija, zavora delovanja kostnega mozga, nevtopenija/agranulocitoza,
However, another angiotensin-II antagonist affected fertility parameters in animal studies when given alone. 
V študijah na živalih so ugotovili, da drugi antagonist angiotenzina II vpliva na plodnost.
The trough to peak effects measured by cuff during office visits were 68 % and 76 % for irbesartan/hydrochlorothiazide 150 mg/12.5 mg and irbesartan/hydrochlorothiazide 300 mg/12.5 mg, respectively. 
Pri merjenju z manšeto v ambulanti je bilo pri bolnikih, ki so jemali kombinacijo irbesartana in hidroklorotiazida 150 mg/12,5 mg, to razmerje 68 %, pri tistih, ki so dobivali kombinacijo irbesartana in hidroklorotiazida 300 mg/12,5 mg, pa 76 %.
Keep this leaflet. 
PRETISNI OMOT
Each film-coated tablet contains 150 mg irbesartan and 12.5 mg hydrochlorothiazide 
Vsaka filmsko obložena tableta vsebuje 150 mg irbesartana in 12,5 mg hidroklorotiazida.
Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin converting enzyme inhibitors. 
Med sočasno uporabo litija in zaviralcev angiotenzinske konvertaze so opazili reverzibilno zvečanje serumske koncentracije litija in toksičnost.
NDEA 
Dojenje
The combination of 300 mg irbesartan and 12.5 mg hydrochlorothiazide resulted in an overall placebo-subtracted systolic/diastolic reductions of up to 13.6/11.5 mmHg. 
Med kombiniranim zdravljenjem s 300 mg irbesartana in 12,5 mg hidroklorotiazida se je sistolični krvni tlak znižal do 13,6 mmHg, diastolični pa do 11,5 mmHg bolj kot po uporabi placeba.
Antigout medicinal products 
Pogoji dovoljenja za promet z zdravilom
Increases in cholesterol and triglyceride levels have been associated with thiazide diuretic therapy; however at the 12.5 mg dose contained in the irbesartan and hydrochlorothiazide combination, minimal or no effects were reported. 
Pri bolnikih, ki so jemali po 12,5 mg hidroklorotiazida, kolikor ga vsebuje kombinacija irbesartana in hidroklorotiazida, je bil ta učinek zelo majhen ali pa ga sploh ni bilo.
The addition of 12.5 mg hydrochlorothiazide to 300 mg irbesartan once daily in patients not adequately controlled on 300 mg irbesartan alone resulted in further placebo-corrected diastolic blood pressure reductions at trough (24 hours post-dosing) of 6.1 mmHg. 
Diastolični krvni tlak se je pri bolnikih, pri katerih zdravljenje s 300 mg irbesartana ni bilo dovolj učinkovito in so začeli jemati tudi po 12,5 mg hidroklorotiazida enkrat na dan, 24 ur po zaužitju odmerka znižal za povprečno 6,1 mmHg bolj kot po uporabi placeba.
A total of 697 patients were randomised in a 2:1 ratio to either irbesartan/hydrochlorothiazide 150 mg/12.5 mg or to irbesartan 150 mg and systemically force-titrated (before assessing the response to the lower dose) after one week to irbesartan/hydrochlorothiazide 300 mg/25 mg or irbesartan 300 mg, respectively. 
Po enem tednu zdravljenja so odmerek sistematično povečali (pred ovrednotenjem odziva na nižji odmerek) na irbesartan/hidroklorotiazid 300 mg/25 mg oziroma irbesartan 300 mg.
• Irbesartan/Hydrochlorothiazide Teva 300 mg/12.5 mg may be administered in patients insufficiently controlled by irbesartan 300 mg or by Irbesartan/Hydrochlorothiazide Teva 150 mg/12.5 mg. 
• Zdravilo Irbesartan/hidroklorotiazid Teva 300 mg/12,5 mg je namenjeno bolnikom, pri katerih se krvni tlak med zdravljenjem s 300 mg irbesartana ali z zdravilom Irbesartan/hidroklorotiazid Teva 150 mg/12,5 mg ni dovolj znižal.
Following oral or intravenous administration of 14C irbesartan, 80-85% of the circulating plasma radioactivity is attributable to unchanged irbesartan. 
C je v obtoku 80 do 85 % nespremenjene učinkovine.
Each film-coated tablet contains 300 mg irbesartan and 12.5 mg hydrochlorothiazide 
Vsaka filmsko obložena tableta vsebuje 300 mg irbesartana in 12,5 mg hidroklorotiazida.
Irbesartan/Hydrochlorothiazide Teva 300 mg/25 mg film-coated tablets irbesartan/hydrochlorothiazide 
Irbesartan/hidroklorotiazid Teva 300 mg/25 mg filmsko obložene tablete irbesartan/hidroklorotiazid
Food does not affect the bioavailability of irbesartan/hydrochlorothiazide. 
Sočasno uživanje hrane na biološko uporabnost kombinacije irbesartana in hidroklorotiazida ne vpliva.
Although not specifically studied with irbesartan/hydrochlorothiazide, rebound hypertension has not been seen with either irbesartan or hydrochlorothiazide. 
Posebnih študij s kombinacijo irbesartana in hidroklorotiazida ni, kljub temu pa povratnega zvišanja krvnega tlaka pri bolnikih, ki so jemali bodisi irbesartan bodisi hidroklorotiazid, po prenehanju jemanja zdravila niso opazili.
Tablet coating for 300 mg/25 mg strength: hypromellose, titanium dioxide, polyethylene glycol 6000 (macrogol), polyethylene glycol 400 (macrogol), iron oxide red, Indigotine (Indigo carmine aluminium lake FD&C blue #2) and iron oxide black. 
(makrogol), polietilenglikol 400 (makrogol), rdeči železov oksid, indigotin (indigo karmin luminijevo rdeče FD&C modro #2), črni železov oksid.
Exacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazide diuretics. 
Pri bolnikih, ki jemljejo tiazidne diuretike, so opazili eksacerbacijo ali aktivacijo sistemskega eritematoznega lupusa.
Each Irbesartan/Hydrochlorothiazide Teva 300 mg/25 mg film-coated tablet contains 300 mg irbesartan and 25 mg hydrochlorothiazide. 
Vsaka Irbesartan/ hidroklorotiazid Teva 300 mg/25 mg filmsko obložena tableta vsebuje 300 mg irbesartana in 25 mg hidroklorotiazida.
What Irbesartan/Hydrochlorothiazide Teva looks like and contents of the pack 
Izgled zdravila Irbesartan/hidroklorotiazid Teva in vsebina pakiranja
Irbesartan/hydrochlorothiazide combination 
Kombinacija irbesartan/hidroklorotiazid:
Microcrystalline cellulose Croscarmellose sodium Colloidal anhydrous silica Magnesium stearate 
premreženi natrijev karmelozat, koloidni brezvodni silicijev dioksid, magnezijev stearat.
Irbesartan/Hydrochlorothiazide Teva 300 mg/25 mg film-coated tablets Each film-coated tablet contains 300 mg of irbesartan and 25 mg of hydrochlorothiazide. 
Irbesartan/hidroklorotiazid Teva 300 mg/25 mg filmsko obložene tablete Vsaka filmsko obložena tableta vsebuje 300 mg irbesartana in 25 mg hidroklorotiazida.
Irbesartan/Hydrochlorothiazide Teva 150 mg/12.5 mg film-coated tablets irbesartan/hydrochlorothiazide 
Irbesartan/hidroklorotiazid Teva 150 mg/12,5 mg filmsko obložene tablete irbesartan/hidroklorotiazid
• Irbesartan/Hydrochlorothiazide Teva 300 mg/25 mg may be administered in patients insufficiently controlled by Irbesartan/Hydrochlorothiazide Teva 300 mg/12.5 mg. 
• Zdravilo Irbesartan/hidroklorotiazid Teva 300 mg/25 mg je namenjeno bolnikom, pri katerih se krvni tlak med zdravljenjem z zdravilom Irbesartan/hidroklorotiazid Teva 300 mg/12,5 mg ni dovolj znižal.
Irbesartan/Hydrochlorothiazide Teva 150 mg/12.5 mg film-coated tablets Each film-coated tablet contains 150 mg of irbesartan and 12.5 mg of hydrochlorothiazide. 
Irbesartan/hidroklorotiazid Teva 150 mg/12,5 mg filmsko obložene tablete Vsaka filmsko obložena tableta vsebuje 150 mg irbesartana in 12,5 mg hidroklorotiazida.
Nausea/vomiting Diarrhoea Dyspepsia, dysgeusia 
Bolezni prebavil pogosti navzea/bruhanje občasni driska neznana dispepsija, paragevzija
Polyethylene Glycol 6000 (Macrogol) Polyethylene Glycol 400 (Macrogol) Iron Oxide Red 
6000 (makrogol), polietilenglikol 400 (makrogol), rdeči železov oksid, rumeni železov oksid,
Other medicines and Irbesartan/Hydrochlorothiazide Teva 
Shranjevanje zdravila Irbesartan/hidroklorotiazid Teva
Protect your skin from sun exposure and UV rays while taking Irbesartan/Hydrochlorothiazide Teva 
Med jemanjem zdravila Irbesartan/hidroklorotiazid Teva zaščitite kožo pred izpostavljenostjo soncu in UV-žarkom.
The two active ingredients in Irbesartan/Hydrochlorothiazide Teva work together to lower blood pressure further than if either was given alone. 
Zdravilni učinkovini v zdravilu Irbesartan/hidroklorotiazid Teva znižujeta krvnitlak, in to še bolj kot če bi jemali vsako učinkovino posebej.
Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. 
Če se intraokularni tlak kljub temu ne zniža, bo morda treba razmisliti o takojšnjem zdravljenju z zdravili ali kirurškem posegu.
Each Irbesartan/Hydrochlorothiazide Teva 150 mg/12.5 mg film-coated tablet contains 150 mg irbesartan and 12.5 mg hydrochlorothiazide. 
Vsaka Irbesartan/hidroklorotiazid Teva 150 mg/12,5 mg filmsko obložena tableta vsebuje 150 mg irbesartana in 12,5 mg hidroklorotiazida.
Additional information on individual components: in addition to the adverse reactions listed above for the combination product, other adverse reactions previously reported with one of the individual components may be potential adverse reactions with Irbesartan/Hydrochlorothiazide Teva. 
Dodatni podatki o posameznih učinkovinah: poleg zgoraj naštetih neželenih učinkov, ki se lahko pojavijo med uporabo kombiniranega zdravila, se utegnejo med jemanjem zdravila
Adequate monitoring of serum potassium in patients at risk is recommended (see section 
Pri bolnikih s povečanim tveganjem je priporočljivo nadzirati vrednosti kalija v serumu (glejte poglavje 4.4).
Interstitial nephritis, renal dysfunction 
Bolezni sečil neznana intersticijski nefritis, motnje delovanja ledvic
Irbesartan/Hydrochlorothiazide Teva 300 mg/12.5 mg film-coated tablets Each film-coated tablet contains 300 mg of irbesartan and 12.5 mg of hydrochlorothiazide. 
Irbesartan/hidroklorotiazid Teva 300 mg/12,5 mg filmsko obložene tablete Vsaka filmsko obložena tableta vsebuje 300 mg irbesartana in 12,5 mg hidroklorotiazida.
Irbesartan/Hydrochlorothiazide Teva 300 mg/12.5 mg film-coated tablets irbesartan/hydrochlorothiazide 
Irbesartan/hidroklorotiazid Teva 300 mg/12,5 mg filmsko obložene tablete irbesartan/hidroklorotiazid
Each Irbesartan/Hydrochlorothiazide Teva 300 mg/12.5 mg film-coated tablet contains 300 mg irbesartan and 12.5 mg hydrochlorothiazide. 
Vsaka Irbesartan/ hidroklorotiazid Teva 300 mg/12.5 mg filmsko obložena tableta vsebuje 300 mg irbesartana in 12,5 mg hidroklorotiazida.
The MAH must ensure that the manufacturing processes of the drug substances used for their drug products are reviewed for the potential risk of formation of Nnitrosamines and changed as necessary to minimise nitrosamine contamination as much as possible. 
N-nitrozaminov in jih po potrebi spremeniti tako, da se onesnaženje z nitrozamini čim bolj zmanjša.
Non-melanoma skin cancer: Based on available data from epidemiological studies, cumulative dosedependent association between HCTZ and NMSC has been observed (see also sections 4.4 and 5.1). 
Nemelanomski kožni rak: Na podlagi obstoječih podatkov epidemioloških študij so ugotovili, da obstaja razmerje med kumulativnim odmerkom hidroklorotiazida in nemelanomskim kožnim rakom
No dosage adjustment of Irbesartan/Hydrochlorothiazide Teva is necessary in older people. 
Zdravilo Irbesartan/hidroklorotiazid Teva je potrebno zaužiti.
Additional information on hydrochlorothiazide interactions When administered concurrently, the following medicinal products may interact with thiazide diuretics: 
Ob sočasni uporabi se lahko pojavijo interakcije med tiazidnimi diuretiki in naslednjimi zdravili: Alkohol
This medicine has been prescribed for you only. 
Zdravilo je bilo predpisano vam osebno in ga ne smete dajati drugim.
Tablet coating for 150 mg/12.5 mg strength: hypromellose, titanium dioxide, polyethylene glycol 6000 (macrogol), polyethylene glycol 400 (macrogol), iron oxide red, iron oxide yellow and iron oxide black. 
Filmska obloga za jakosti 150 mg/12,5 mg in 300 mg/12,5 mg: hipromeloza titanov dioksid polietilenglikol 6000 (makrogol) polietilenglikol 400 (makrogol)
Additional information on irbesartan interactions 
Dodatni podatki o medsebojnem delovanju s hidroklorotiazidom
Tablet coating for 300 mg/12.5 mg strength: hypromellose, titanium dioxide, polyethylene glycol 6000 (macrogol), polyethylene glycol 400 (macrogol), iron oxide red, iron oxide yellow and iron oxide black. 
Filmska obloga za jakost 300 mg/25 mg: hipromeloza titanov dioksid polietilenglikol 6000 (makrogol) polietilenglikol 400 (makrogol)
Corticosteroids, ACTH Electrolyte depletion, particularly hypokalaemia, may be increased; 
Znižanje elektrolitov, še posebej kalija (hipokaliemija).
Posology 
Zdravila
Cardiac arrhythmias 
hemolitična anemija,
Dosage adjustments of antigout medicinal products may be necessary as hydrochlorothiazide may raise the level of serum uric acid. 
Zdravila za zdravljenje protina Hidroklorotiazid lahko zveča serumsko koncentracijo sečne kisline, zato je treba v takem primeru odmerek zdravil za zdravljenje protina prilagoditi.
Jaundice (intrahepatic cholestatic jaundice) 
Bolezni jeter, žolčnika in žolčevodov neznana zlatenica (intrahepatska holestatska zlatenica)