natgillin/translations-raw huggingface dataset:
• he/she has a close contact such as a household member who has a weakened immune system, 
• je otrok v tesnem stiku z družinskim članom, ki ima oslabljen imunski sistem, npr. z bolnikom z rakom ali bolnikom, ki jemlje zdravila, ki bi lahko oslabila imunski sistem; • ima otrok kakršnekoli težave s prebavili;
In three comparative controlled trials, the immune response elicited by Rotarix liquid formulation was comparable to the one elicited by Rotarix lyophilised formulation. 
Rotarix primerljiv z imunskim odzivom po aplikaciji liofilizirane oblike cepiva Rotarix.
B. PACKAGE LEAFLET 
B. Priprava tube
Remove the oral applicator from the transfer adapter 
Peroralni aplikator odstranite iz nastavka za prenos.
• flatulence 
-Urtikarija
• children with a rare inherited illness called Severe Combined Immunodeficiency (SCID) may have an inflamed stomach or gut (gastroenteritis) and pass the vaccine virus in their stools. 
(SCID), lahko dobijo vnetje želodca ali črevesja (gastroenteritis) in izločajo virus iz cepiva z blatom.
NAME OF THE MEDICINAL PRODUCT Rotarix powder and solvent for oral suspension Rotavirus vaccine, live 
Navodilo za uporabo Rotarix prašek in vehikel za peroralno suspenzijo cepivo proti rotavirusom, živo
Gastrointestinal disorders 
(gastroenteritis katerekoli jakosti).
Oral administration only 
Samo za peroralno uporabo
- The other ingredients in Rotarix are: sucrose (see also section 2, Rotarix contains sucrose), Di sodium Adipate, Dulbecco's Modified Eagle Medium (DMEM), sterile water What Rotarix looks like and contents of the pack Oral suspension in pre-filled oral applicator. 
*Pridobljen na Vero celicah - Pomožne snovi cepiva Rotarix so: Prašek: dekstran, saharoza, sorbitol, (glejte tudi poglavje 2, Cepivo Rotarix vsebuje saharozo in sorbitol), aminokisline, Dulbekov spremenjeni nujni medij (DMEM - »Dulbecco's Modified Eagle Medium«) Vehikel: kalcijev karbonat, ksantanski gumi, voda za injekcije Izgled cepiva Rotarix in vsebina pakiranja Prašek in vehikel za peroralno suspenzijo Cepivo Rotarix je na voljo v enoodmerni steklenički z belkastim praškom in v ločenem z vehiklom napolnjenem peroralnem aplikatorju, ki vsebuje počasi usedajočo se belo usedlino in brezbarven supernatant.
Transfer adapter 
Nastavek za prenos
All G1P[8] 
< 3 leta vsi G1P[8]
Intussusception 
Odmerjanje
(see section 4.4) 
Sevi z genotipom P[4]
Age range 
Starostni razpon
NAME OF THE MEDICINAL PRODUCT Rotarix oral suspension in pre-filled oral applicator Rotavirus vaccine, live 
Rotarix peroralna suspenzija v napolnjenem peroralnem aplikatorju Cepivo proti rotavirusom, živo
A white deposit and clear supernatant is observed upon storage of the oral applicator containing the solvent. 
Med shranjevanjem se v peroralnem aplikatorju z vehiklom pojavi bela usedlina in bister supernatant.
2nd year of life Rotarix N=2,554 Placebo N=1,294 Vaccine efficacy (%) against any and severe rotavirus gastro-enteritis [95% CI] 
Drugo leto življenja Rotarix n=2.554 Placebo n=1.294
10 x 5 single dose tubes connected by a bar 1 dose (1.5 ml) 
10 x 5 enoodmernih tub, povezanih s ploščico
These data should be interpreted with caution # The numbers of cases, on which the estimates of efficacy against G4P[8] were based, were very small (1 case in the Rotarix group and 2 cases in the placebo group) A pooled analysis of five efficacy studies*, showed a 71.4% (95% CI: 20.1;91.1) efficacy against severe rotavirus gastro-enteritis (Vesikari score ≥11) caused by rotavirus G2P[4] genotype during the first year of life. 
Združena analiza petih študij* kaže, da je bila med prvim letom življenja učinkovitost proti hudemu rotavirusnemu gastroenteritisu (Vesikari ≥ 11), ki ga povzroča genotip G2P[4] rotavirusa 71,4
• Hold for at least 30 seconds. 
• Držite vsaj 30 sekund.
Drinking alcohol may make these effects worse. 
Pitje alkohola lahko te učinke poslabša.
Adults and Children: 
Odrasli in otroci:
{Name and Address} <{tel}> <{fax}> <{e-mail}> 
{Ime in naslov} {tel.} {faks} {e-pošta}
If your pain gets worse 
Če se bolečina poslabša
You may need urgent medical treatment. 
Morda boste potrebovali nujno zdravniško pomoč.
If this happens, do not drive or use any tools or machines. 
Če se to zgodi, ne vozite ali uporabljajte orodij ali strojev.
How quickly will the patches work? 
Kako hitro bodo obliži delovali?
- see below for more information 
- več informacij najdete spodaj
• You are elderly - you may be more sensitive to the effects of this medicine. 
• če ste starejši - lahko boste bolj občutljivi za učinke tega zdravila
The tendency of tolerance development varies widely among individuals. 
Nagnjenost k razvoju tolerance je med posamezniki zelo različna.
Reference: Adapted from 1) Foley KM. 
Referenci: povzeto po 1) Foley KM.
Your doctor will talk to you about this. 
Zdravnik vam bo svetoval glede tega.
• The same place twice in a row. 
• isto mesto dvakrat zaporedoma.
Symptoms and signs 
Simptomi in znaki
In the next 12 hours, these analgesics should be provided based on clinical need. 
V naslednjih 12 urah je treba te analgetike dajati glede na klinične potrebe.
• If you have been using them for some time your body may have got used to them. 
• Če ste obliže uporabljali že dalj časa, se je vaše telo lahko navadilo nanje.
Use a new area of skin on: 
Uporabite nov predel kože:
Effects on somatic development and behaviour of the offspring were not observed. 
Vpliva na somatski razvoj in vedenje potomcev niso opazili.
• If you are using more than one patch, change all your patches at the same time. 
• Če uporabljate več kot en obliž, vse obliže zamenjajte ob istem času.
• Reduced consciousness or loss of consciousness. 
• Zmanjšana stopnja zavesti ali izguba zavesti.
This includes medicines that you buy without a prescription or herbal medicines. 
To vključuje tudi zdravila, ki jih kupite brez recepta ali zdravila rastlinskega izvora.
Adequate body temperature and fluid intake should be maintained. 
Vzdrževati je treba ustrezno telesno temperaturo in vnos tekočin.
Children 2 to 16 years old 
Otroci, stari od 2 do 16 let
• You have ever abused or been dependent on alcohol, prescription medicines or illegal drugs. 
• če ste kadar koli zlorabljali ali bili odvisni od alkohola, zdravil na recept ali prepovedanih drog.
• Your child's upper back 
• zgornji del hrbta vašega otroka.
• If you need to clean the skin, just use cold water 
• Če morate kožo umiti, uporabite hladno vodo.
• You should change your patch every third day, unless your doctor has told you differently. 
• Obliž morate zamenjati vsak tretji dan, razen če vam zdravnik ne naroči drugače.
Instead, clip the hair as close to the skin as possible. 
Namesto tega dlake postrizite s škarjami čim bližje koži.
It may harm them, even if their signs of illness are the same as yours 
Njim bi lahko celo škodovalo, čeprav imajo znake bolezni, podobne vašim.
• You can also swim while wearing the patch, but: 
• Med uporabo obliža lahko tudi plavate, vendar:
• It is important that your child does not remove the patch and put it in their mouth as this could be life threatening or even fatal. 
• Pomembno je, da vaš otrok obliža ne odstrani in ga da v usta, saj bi to lahko bilo življenjsko nevarno ali celo smrtno.
Do not drive while using this medicine until you know how it affects you. 
Ne vozite, dokler uporabljate to zdravilo in ne veste, kako vpliva na vas.
After an increase in dose, it may take up to 6 days for the patient to reach equilibrium on the new dose level. 
Po povečanju odmerka lahko traja do 6 dni, da bolnik na novem odmerku doseže ravnovesje.
Both the minimum effective concentration and the toxic concentration increase with tolerance. 
Tako minimalna učinkovita koncentracija kot tudi toksična koncentracija s toleranco naraščata.
• Use each patch once only 
• Vsak obliž uporabite le enkrat.
Dosage must not be increased in intervals of less than 72 hours. 
Odmerka se ne sme povečevati v intervalih, krajših od 72 ur.
This may occur within the recommended dose. 
To se lahko pojavi tudi pri jemanju priporočenega odmerka.
• Seeing, feeling, hearing, or smelling things that are not there (hallucinations) 
• videnje, čutenje, slišanje ali vohanje stvari, ki jih ni (halucinacije)
NEJM 1985; 313 (2): 84-95 and 2) McPherson ML. 
NEJM 1985; 313 (2): 84-95 in 2) McPherson ML. Introduction to opioid conversion calculations.
• Feeling cold 
• občutek mraza
Its primary therapeutic actions are analgesia and sedation. 
Njegova glavna terapevtska učinka sta analgezija in sedacija.
How long will you use the patches for? 
Kako dolgo boste uporabljali obliže?
• Loss of memory 
• izguba spomina
• Difficulty getting and keeping an erection (impotence) or problems having sex 
• težave z vzpostavitvijo in ohranjanjem erekcije (impotenca) ali težave pri spolnosti
The risk of side effects increases if you are taking medicines such as certain antidepressants. 
Tveganje za pojav neželenih učinkov se poveča, če jemljete zdravila, kot so nekateri antidepresivi.
An optimal therapeutic concentration range of fentanyl can therefore not be established. 
Zaradi tega optimalne terapevtske koncentracije ne moremo določiti.
In such circumstances, the patient must be closely monitored. 
Bolnika je treba skrbno spremljati.
Drug dependence and potential for abuse 
Odvisnost od zdravila in možnost zlorabe
• Each patch is sealed in its own sachet 
• Vsak obliž je zavarjen v svojo vrečico.
Depending on the additional analgesic needs and the pain status of the child, it may be decided to increase the dose. 
Odvisno od dodatnih potreb po analgeziji in izraženosti bolečine pri otroku se je mogoče odločiti za povečanje odmerka.
• If you stop using the patches, don't start again without asking your doctor first. 
• Če obliže prenehate uporabljati, jih ne začnite ponovno uporabljati ne da bi se pred tem najprej posvetovali z vašim zdravnikom.
• Do not take the patch out of its sachet until you are ready to use it 
• Obliža ne vzemite iz vrečice, dokler niste pripravljeni, da ga boste uporabili.
Everyday activities while using the patches 
Vsakodnevne aktivnosti med uporabo obliža
• There is enough medicine in each patch to last 3 days (72 hours). 
• V vsakem obližu je dovolj zdravila, da zadostuje za 3 dni (72 ur).
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION <Date of first authorisation: {DD month YYYY}> <Date of latest renewal: {DD month YYYY}> 
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum prve odobritve: {DD. mesec LLLL} Datum zadnjega podaljšanja: {DD. mesec LLLL}
Eighty of the children were aged 2 to 6 years, inclusive. 
Osemdeset otrok je bilo starih 2 do 6 let.
Step 1: Preparing the skin 
1. korak: Priprava kože
A mutagenic risk for the use of therapeutic doses seems unlikely since effects appeared only at high concentrations. 
Tveganje mutagenih učinkov se zdi pri uporabi terapevtskih odmerkov malo verjetno, saj so se učinki pojavili samo pri velikih koncentracijah.
Fentanyl can be abused in a manner similar to other opioid agonists. 
Fentanil je možno zlorabiti na podoben način kot ostale opioidne agoniste.
• Your doctor may give you other painkillers as well for the first day or so 
• Vaš zdravnik vam utegne dati še dodatna protibolečinska zdravila za prvi dan ali dva.
Standard reproductive and developmental toxicity studies have been carried out using parenteral administration of fentanyl. 
Standardne študije reproduktivne in razvojne toksičnosti so opravili s parenteralnim dajanjem fentanila.
4.5 Interaction with other medicinal products and other forms of interaction 
4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Interakcije, povezane s farmakodinamiko
The adverse reactions are presented by System Organ Class and in order of decreasing seriousness within each frequency category. 
Neželeni učinki so navedeni po organskih sistemih in padajoči resnosti znotraj vsake kategorije pogostnosti.
Change the patch again after 3 days (72 hours) as usual. 
Obliž ponovno zamenjajte po 3 dneh (72 urah) kot običajno.
• You have pain which lasts only for a short period, such as sudden pain or pain after having an operation 
• če imate bolečine, ki trajajo le krajše obdobje, npr. nenadna bolečina ali bolečina po kirurškem posegu,
• You have ever had persistent headaches or a head injury 
• če ste kadar koli imeli vztrajne glavobole ali poškodbo glave
Abuse or intentional misuse of DUROGESIC may result in overdose and/or death. 
Zloraba ali namerna napačna uporaba zdravila DUROGESIC lahko vodi v prekomerno odmerjanje in/ali smrt.
Opioids may cause hypotension, especially in patients with acute hypovolaemia. 
Opioidi lahko povzročijo hipotenzijo, še posebno pri bolnikih z akutno hipovolemijo.
This may result in increased serum concentrations (see section 5.2) and the patient should be monitored closely. 
To lahko privede do zvečanja serumskih koncentracij (glejte poglavje 5.2), zato je treba bolnika skrbno spremljati.
• Make sure that the patch will be covered by loose clothing and not stuck under a tight or elasticated band 
• Poskrbite, da bo obliž nameščen pod ohlapnimi oblačili in ne pod tesnim ali elastičnim trakom.
Alternative routes of administration (oral, parenteral) should be considered. 
Razmisliti je treba o drugih načinih uporabe (peroralna, parenteralna).
Studies in animals have shown some reproductive toxicity (see section 5.3). 
Študije na živalih so pokazale nekaj reprodukcijske toksičnosti (glejte poglavje 5.3).
The patches help relieve pain that is very bad and long-lasting: 
Obliži pomagajo lajšati hude in dolgotrajne bolečine:
• Watch your child very closely for 48 hours after: - The first patch has been put on - A higher dose patch has been put on 
• Otroke je treba zelo pozorno spremljati 48 ur po: - prvi namestitvi obliža
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine. 
Če ste noseči ali dojite, menite da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo.
In a study on pre- and postnatal development the survival rate of offspring was significantly reduced at doses which slightly reduced maternal weight. 
V študiji pre- in postnatalnega razvoja je bila stopnja preživetja mladičev pomembno zmanjšana pri odmerkih, ki so nekoliko zmanjšali telesno maso samice.
Soaps, oils, lotions, or any other agent that might irritate the skin or alter its characteristics should not be used. 
Mila, olj, losjonov ali drugih sredstev, ki bi lahko razdražila kožo in spremenila njene lastnosti, se ne sme uporabiti.
The average bioavailability of fentanyl after application of the transdermal patch is 92%. 
Povprečna biološka uporabnost fentanila po aplikaciji transdermalnega obliža je 92%.
It should be noted that this conversion schedule for children only applies to the switch from oral morphine (or its equivalent) to DUROGESIC patches. 
Upoštevati je treba, da ta shema preračunavanja za otroke velja le v primeru prehoda s peroralnega morfina (ali njegovega ekvivalenta) na transdermalne obliže DUROGESIC.
In a study in cancer patients treated with transdermal fentanyl, plasma protein binding was on average 95% (range 77-100%). 
V študiji pri bolnikih z rakom, ki so prejemali fentanil transdermalno, je bila povprečna vezava na plazemske beljakovine 95 % (od 77 do 100 %).
• Always change your patch at the same time of day every 3 Days (72 hours). 
• Obliž vedno zamenjajte ob istem času vsake 3 dni (72 ur).
Adjusting for body weight, clearance (L/h/kg) appears to be approximately 80% higher in children 2 to 5 years old and 25% higher in children 6 to 10 years old when compared to children 11 to 16 years old, who are expected to have a similar clearance as adults. 
Očistek (l/h/kg), ob upoštevanju telesne mase, je približno 80% večji pri otrocih, starih 2 do 5 let, in za 25% večji pri otrocih, starih 6 do 10 let, kot pri otrocih, starih 11 do 16 let, pri katerih se pričakuje podoben očistek kot pri odraslih.
• Swollen hands, ankles or feet (peripheral oedema) 
• otečene dlani, gležnji ali stopala (periferni edem)
6.6 Special precautions for disposal and other handling Instructions for disposal: 
6.6 Posebni varnostni ukrepi za odstranjevanje Navodila za odstranjevanje:
If there is hair, do not shave it (shaving irritates the skin). 
Če so na koži dlake, jih ne brijte (britje draži kožo).
• Make a note of the day, date and time you apply a patch, to remind you when you need to change your patch. 
• Zapišite si dan, datum in čas, ko ste si obliž namestili, da boste vedeli, kdaj morate obliž zamenjati.
• Slow heart beat (bradycardia) or low blood pressure 
• počasnejše bitje srca (bradikardija) ali nizek krvni tlak
• You have a condition called ‘myasthenia gravis' in which muscles become weak and tire easily. 
• če imate bolezen, imenovano miastenija gravis, pri kateri mišice postanejo šibke in se hitro utrudijo
Following a 72-hour patch application, the mean fentanyl half-life ranges from 20 to 27 hours. 
Po 72 urni aplikaciji je povprečni razpolovni čas 20-27 ur.
However, your doctor may still prescribe extra painkillers from time to time 
Kljub temu vam bo zdravnik morda od časa do časa predpisal dodatna protibolečinska zdravila.
• You have ever had a brain tumour 
• če ste kadar koli imeli možganski tumor
A carcinogenicity study (daily subcutaneous injections of fentanyl hydrochloride for two years in Sprague Dawley rats) did not induce any findings indicative of oncogenic potential. 
V študiji kancerogenosti (dnevne podkožne injekcije fentanilijevega klorida v obdobju dveh let pri podganah Sprague Dawley) ni bilo ugotovitev, ki bi kazale na onkogeni potencial.
• Blue colour to the skin caused by low oxygen in the blood (cyanosis) 
• modro obarvanje kože zaradi pomanjkanja kisika v krvi (cianoza)
• You have ever had problems with your heart, liver, kidneys, or low blood pressure 
• če ste kadar koli imeli težave s srcem, jetri, ledvicami ali nizek krvni tlak
DUROGESIC should not be used in children aged less than 2 years because the safety and efficacy have not been established. 
Zdravilo DUROGESIC se ne sme uporabljati pri otrocih, mlajših od 2 let, ker varnost in učinkovitost še nista bili dokazani.
The pharmacokinetics of transdermal fentanyl do not change with repeated application. 
Farmakokinetika transdermalnega fentanila se s ponavljajočimi aplikacijami ne spremeni.
Other factors to be considered are the current general condition and medical status of the patient, including body size, age, and extent of debilitation as well as degree of opioid tolerance. 
Upoštevati je treba tudi trenutno splošno in zdravstveno stanje bolnika, vključno z velikostjo, starostjo, obsegom prizadetosti in stopnjo tolerance na opioide.
* the assigned frequency (uncommon) is based on analyses of incidence including only adult and paediatric clinical study subjects with non-cancer pain. 
*dodeljena pogostnost (občasni) temelji na analizi pogostnosti, v katero so vključili samo odrasle in pediatrične preiskovance z bolečinami, ki niso bile povezane z rakavimi obolenji.
• You can shower or bathe while wearing a patch, but do not scrub the patch itself 
• Med uporabo obliža se lahko tuširate ali kopate, vendar samega obliža ne drgnite.
<[To be completed nationally]> <Other sources of information> <Detailed information on this medicine is available on the website of {name of MS Agency (link)}> 
Drugi viri informacij <Podrobne informacije o zdravilu so objavljene na spletni strani {ime agencije v državi članici (povezava)}
Fentanyl accumulates in skeletal muscle and fat and is released slowly into blood. 
Fentanil se akumulira v skeletnih mišicah in maščobi ter se počasi sprošča v kri.
• If you are very late changing your patch, you should talk to your doctor because you might need some extra painkillers, but do not apply an extra patch. 
• Če ste pri zamenjavi obliža zelo pozni, obvestite zdravnika, ker boste morda potrebovali dodatna protibolečinska zdravila, vendar si dodatnega obliža ne namestite.
Pharmacotherapeutic group: Analgesics, Opioids, phenylpiperidine derivatives, ATC code: N02AB03 
Farmakoterapevtska skupina: opioidi; derivati fenilpiperidina Oznaka ATC: N02AB03
You should also tell your pharmacist that you are using DUROGESIC if you buy any medicines from your pharmacy. 
Tudi farmacevtu morate povedati, da uporabljate zdravilo DUROGESIC, če boste v lekarni kupili katero koli zdravilo.
Opioid withdrawal symptoms are possible in some patients after conversion or dose adjustment. 
Opioidni odtegnitveni simptomi so pri nekaterih bolnikih možni po zamenjavi zdravila ali prilagoditvi odmerka.
• Do not stick a patch on straight after a hot bath or shower 
• Obliža si ne namestite takoj po vroči kopeli ali tušu.
Reversal of the narcotic effect may result in acute onset of pain and release of catecholamines. 
Odprava narkotičnega učinka lahko povzroči akuten pojav bolečin in sproščanje kateholaminov.
Avoid touching the adhesive side of the patch. 
Izogibajte se dotikanju lepljive strani obliža.
Fentanyl crosses the blood-brain barrier easily. 
Fentanil zlahka prehaja skozi krvno-možgansko bariero.
Bear in mind that a sticky patch (unused or used) could be tempting to a child and if it sticks to a child's skin or they put it in their mouth, the result may be fatal. 
Ne pozabite, da je lepljiv obliž (neuporabljen ali uporabljen) lahko privlačen za otroka in, če se prilepi na otrokovo kožo ali ga otrok da v usta, lahko povzroči smrt.
• After this, the patch should help to relieve pain continuously so that you can stop taking other painkillers. 
• Potem bi obliž moral odpravljati bolečino nepretrgano in boste lahko prenehali jemati druga protibolečinska zdravila.
The expiry date refers to the last date of that month. 
Datum uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
After intravenous administration, fentanyl mean total clearance values across studies range in general between 34 and 66 L/h. 
Po intravenskem injiciranju so bile skupne povprečne vrednosti očistka fentanila med študijami v splošnem med 34 in 66 l/h.
• Decreased feeling or sensitivity, especially in the skin (hypoaesthesia) 
• zmanjšana občutljivost na dražljaje, zlasti v koži (hipestezija)
This leaflet was last revised in <{MM/YYYY}> <{month YYYY}>. 
Navodilo je bilo nazadnje revidirano dne <{MM/LLLL}> <{mesec LLLL}>
Initial dosage selection 
Izbira začetnega odmerka
This is usually mild and disappears after you have removed the patch. 
To je običajno blago in izzveni, ko odstranite obliž.
• Areas that you move a lot (joints), skin that is irritated or with cuts. 
• območja, ki jih zelo veliko premikate (sklepi), razdraženo kožo ali kožo z vrezninami.
• Every so often check that the patch remains stuck to the skin. 
• Vsake toliko časa preverite, da obliž ostane dobro prilepljen na kožo.
• You are allergic to fentanyl or any of the other ingredients of this medicine (listed in section 6) 
• če ste alergični na fentanil ali katero koli sestavino tega zdravila (navedeno v poglavju 6),
Therefore, your child might need to use other painkillers as well until the patches become effective. 
Zato bo vaš otrok morda potreboval dodatna protibolečinska zdravila, dokler obliž ne začne delovati v celoti.
Children aged 16 years and above Follow adult dosage. 
Otroci, stari 16 let in starejši Upoštevajte odmerjanje za odrasle.
• If a patch falls off before it needs changing, stick a new one on straight away and make note of the day and time. 
• Če se vam obliž odlepi, preden je čas za zamenjavo, si takoj namestite novega in zabeležite dan in čas.
Due to accumulation, the AUC and Cmax values over a dosing interval at steady state are approximately 40% higher than after a single application. 
Zaradi akumulacije sta vrednosti AUC in Cmax med celotnim intervalom odmerjanja v dinamičnem ravnovesju približno za 40% večji kot po enkratni aplikaciji.
DUROGESIC has not been studied in children under 2 years of age. 
Zdravila DUROGESIC niso preučevali pri otrocih, mlajših od 2 let.
Apply the patch to the skin by applying light pressure with the palm of the hand for about 30 seconds. 
Obliž prilepimo na kožo tako, da ga z dlanjo pritiskamo na kožo približno 30 sekund.