natgillin/translations-raw huggingface dataset:
What Daptomycin Hospira contains - The active substance is daptomycin. 
Kaj vsebuje zdravilo Daptomicin Hospira - Učinkovina je daptomicin.
The pharmacokinetics of daptomycin in paediatric subjects was evaluated in 3 single-dose pharmacokinetic studies. 
Farmakokinetiko daptomicina pri pediatričnih bolnikih so ocenili v 3 farmakokinetičnih študijah z enim odmerkom.
Please inform your doctor that you are on treatment with Daptomycin Hospira. 
Zdravniku povejte, da se zdravite z zdravilom Daptomicin Hospira.
Daptomycin administration was associated with minimal to mild degenerative/regenerative changes in skeletal muscle in the rat and dog. 
Dajanje daptomicina je bilo pri podganah in psih povezano z minimalnimi do blagimi degenerativnimi/regenerativnimi spremembami skeletnih mišic.
However, daptomycin can cross the placenta in pregnant rats (see section 5.2). 
Vendar pa daptomicin pri brejih podganah lahko prehaja skozi placento (glejte poglavje 5.2).
1 to <2 years (N=30) 
1 do < 2 leti (N = 30)
The pharmacokinetics of daptomycin in patients with severe hepatic impairment (Child-Pugh C classification) have not been evaluated. 
Farmakokinetike daptomicina pri bolnikih s hudo okvaro jeter (razred C po lestvici Child-Pugh) niso ovrednotili.
Hypertension, hypotension Uncommon: Flushes 
hipertenzija, hipotenzija občasni:
The combined storage time (reconstituted solution in vial and diluted solution in infusion bag) at 25°C must not exceed 12 hours (24 hours if refrigerated). 
Skupni čas shranjevanja (rekonstituirana raztopina v viali in razredčena raztopina v infuzijski vrečki) pri 25 °C ne sme presegati 12 ur (ali 24 ur v primeru shranjevanja v hladilniku).
No clinical data on pregnancies are available for daptomycin. 
Za daptomicin ni na voljo nobenih kliničnih podatkov o nosečnostih.
Anticoagulant activity in patients receiving daptomycin and warfarin should be monitored for the first several days after therapy with Daptomycin Hospira is initiated. 
Pri bolnikih, ki prejemajo daptomicin in varfarin, je treba prvih nekaj dni po uvedbi zdravila Daptomicin Hospira spremljati njihovo antikoagulantno aktivnost.
Sodium hydroxide Citric acid 
natrijev hidroksid citronska kislina
The polypropylene flip off cap should be removed to expose the central portion of the rubber stopper. 
Snemljivo zaporko iz polipropilena morate odstraniti, da razkrijete osrednji del gumijastega zamaška.
Based on pharmacokinetic data and modelling, the daptomycin AUC during the first day after administration of a 6 mg/kg dose to adult patients on HD or CAPD was 2-fold higher than that observed in adult patients with normal renal function who received the same dose. 
Glede na farmakokinetične podatke in modeliranje je bila vrednost AUC daptomicina prvi dan po uporabi odmerka 6 mg/kg pri odraslih bolnikih na HD ali CAPD dvakrat večja kot pri odraslih bolnikih z normalnim delovanjem ledvic, ki so prejeli enak odmerek.
- That daptomycin susceptibility testing needs Ca in the testing medium and testing methods with mediums providing consistent Ca concentrations are recommended. 
- da mora biti pri testiranju občutljivosti za daptomicin v testnem mediju prisoten kalcij in da so priporočljive testne metode, ki zagotavljajo stalno koncentracijo kalcija v testnem mediju.
Deep-seated infections 
Globoke okužbe
Population 
ITT populacija
Daptomycin Hospira given as 2-minute intravenous injection (adult patients only) 
Zdravilo Daptomicin Hospira za dajanje v obliki 2-minutne intravenske injekcije (samo odrasli bolniki)
The possibility of erroneous results may be minimised by drawing samples for PT or INR testing near the time of trough plasma concentrations of daptomycin (see section 
Možnost napačnih rezultatov lahko zmanjšamo tako, da vzorce za določitev PČ ali INR odvzamemo približno v času, ko so koncentracije daptomicina v plazmi najnižje (glejte poglavje 4.4).
Release the syringe plunger and allow the syringe plunger to equalise the pressure before removing the syringe from the vial. 
Sprostite bat injekcijske brizge in pustite, da bat injekcijske brizge izenači tlak, preden injekcijsko brizgo odstranite iz viale.
In adult patients, this dose is given directly into your blood stream (into a vein), either as an infusion lasting about 30 minutes or as an injection lasting about 2 minutes. 
Odrasli bolniki prejmete ta odmerek neposredno v krvni obtok (v veno), bodisi v obliki infuzije, ki traja okrog 30 minut, bodisi v obliki injekcije, ki traja približno 2 minuti.
The overall therapeutic response rate also was similar for the daptomycin and SOC treatment arms for infections caused by MRSA, MSSA and Streptococcus pyogenes (see table below; ME population); response rates were > 94% for both treatment arms across these common pathogens. 
Tudi skupna stopnja terapevtskega odziva pri okužbah z bakterijami MRSA, MSSA in Streptococcus pyogenes je bila v skupini z daptomicinom podobna kot v skupini s standardno oskrbo (glejte preglednico spodaj, podatki populacije za mikrobiološko oceno primernih bolnikov): pri vseh običajnih patogenih je bila stopnja odziva v obeh študijskih skupinah > 94 %.
Following administration of a single 4 mg/kg or 6 mg/kg intravenous dose of daptomycin over a 30-minute period to adult subjects with various degrees of renal impairment, total daptomycin clearance (CL) decreased and systemic exposure (AUC) increased as renal function (creatinine clearance) decreased. 
Po 30-minutnem dajanju enkratnega intravenskega odmerka 4 mg/kg ali 6 mg/kg daptomicina odraslim osebam z različnimi stopnjami okvare ledvic se je z zmanjševanjem delovanja ledvic (očistka kreatinina) celotni očistek daptomicina zmanjševal, sistemska izpostavljenost (AUC) pa povečevala.
In paediatric patients under 7 years old receiving a 9-12 mg/kg dose, daptomycin should be administered over 60 minutes (see sections 4.2 and 5.2). 
Pediatričnim bolnikom, mlajšim od 7 let, ki prejemajo odmerek 9-12 mg/kg, je treba daptomicin dati v 60 minutah (glejte poglavji 4.2 in 5.2).
Common: 
občasni:
On the second day after administration of a 6 mg/kg dose to HD and CAPD adult patients the daptomycin AUC was approximately 1.3-fold higher than that observed after a second 6 mg/kg dose in adult patients with normal renal function. 
Drugi dan po dajanju odmerka 6 mg/kg odraslim bolnikom na HD ali CAPD je bila njihova vrednost AUC daptomicina približno 1,3krat večja kot pri odraslih bolnikih z normalnim delovanjem ledvic po drugem odmerku 6 mg/kg.
No preservative or bacteriostatic agent is present in this product. 
To zdravilo ne vsebuje konzervansov ali bakteriostatikov.
Sodium hydroxide (for pH adjustment) Citric acid (solubiliser/stabiliser) 
6.1 Seznam pomožnih snovi natrijev hidroksid (za uravnavanje pH) citronska kislina (sredstvo za raztapljanje/stabilizator)
Gender No clinically significant gender-related differences in daptomycin pharmacokinetics have been observed. 
V farmakokinetiki daptomicina niso opazili nikakršnih klinično pomembnih razlik, povezanih s spolom.
The specific cell surface component directly targeted has not been identified. 
Specifične strukture celične površine, na katero daptomicin neposredno deluje, niso ugotovili.
Replace needle with a new needle for the intravenous injection. 
Injekcijsko iglo zamenjajte z novo iglo za intravensko injiciranje.
<Date of first authorisation: 22-March-2017> <Date of latest renewal: {DD month YYYY}> 
Datum prve odobritve: 22. marec 2017
Daptomycin is primarily cleared by renal filtration and so plasma levels may be increased during co-administration with medicinal products that reduce renal filtration (e.g. NSAIDs and COX-2 inhibitors). 
Daptomicin se primarno izloča z ledvično filtracijo, torej lahko sočasna uporaba zdravil, ki zavirajo ledvično filtracijo (npr. nesteroidna protivnetna zdravila in zaviralci COX-2), povzroči zvišanje njegovih ravni v plazmi.
Creatine phosphokinase (CPK) levels must be measured at baseline and at regular intervals (at least weekly) during treatment (see section 4.4). 
Vrednost kreatin-fosfokinaze (CPK) je treba izmeriti pred začetkom zdravljenja in nato v rednih presledkih med zdravljenjem (vsaj enkrat na teden) (glejte poglavje 4.4).
Very rare serious side effects (may affect up to 1 in 10,000 people) A hypersensitivity reaction (serious allergic reaction including anaphylaxis, angioedema, drug rash with eosinophilia and systemic symptoms (DRESS)) has been reported, in some cases during administration of daptomycin. 
Zelo redki resni neželeni učinki (pojavijo se lahko pri največ 1 od 10.000 bolnikov) Poročali so o preobčutljivostni reakciji (resni alergijski reakciji, ki vključuje anafilaksijo, angioedem, z zdravilom povezan izpuščaj z eozinofilijo in sistemskimi simptomi (DRESS - Drug Reaction with Eosinophilia and Systemic Symptoms)), v nekaterih primerih med dajanjem daptomicina.
Uncommon: Supraventricular tachycardia, extrasystole 
supraventrikularna tahikardija, ekstrasistole
There is limited experience regarding concomitant administration of daptomycin with other medicinal products that may trigger myopathy (e.g. HMG-CoA reductase inhibitors). 
Izkušnje glede sočasne uporabe daptomicina z drugimi zdravili, ki lahko povzročijo miopatijo (na primer z zaviralci reduktaze HMG-CoA), so omejene.
Blood and lymphatic system disorders 
Bolezni krvi in limfatičnega sistema pogosti:
What you need to know before you are given Daptomycin Hospira 
Kaj morate vedeti, preden boste uporabili zdravilo Daptomicin Hospira
Before removing the needle from the vial, pull the plunger all the way back to the end of the syringe barrel in order to remove all of the solution from the inverted vial. 
Preden injekcijsko iglo izvlečete iz viale, potegnite bat povsem do konca tulca injekcijske brizge tako, da lahko iz obrnjene viale odstranite celotno raztopino.
The site of metabolism has not been identified. 
Mesta presnove niso ugotovili.
7-11 years (N=19) 
7-11 let (N = 19)
In paediatric patients under 7 years old receiving a 9-12 mg/kg dose, daptomycin should be administered over 60 minutes. 
Pediatričnim bolnikom, mlajšim od 7 let, ki prejemajo odmerek 9-12 mg/kg, je treba daptomicin dati v 60 minutah.
Dosage Regimen 
Režim odmerjanja
Differences in Success n/N (%) 
Razlike v spešnosti n/N (%)
Age Range 12-17 years (N=6) 7-11 years (N=2) 
12-17 let (N = 6) 7-11 let (N = 2)
If you experience these symptoms, tell your doctor or nurse straight away. 
Če opazite navedene simptome, takoj obvestite svojega zdravnika ali medicinsko sestro.
Obesity In obese subjects with Body Mass Index (BMI) >40 kg/m2 but with creatinine clearance >70 ml/min, the 
Debelost Pri debelih preskušancih z indeksom telesne mase (ITM) > 40 kg/m2 in očistkom kreatinina >
For the 2-minute intravenous injection, the storage time of the reconstituted solution in the vial (see section 6.6) at 25°C must not exceed 12 hours (or 48 hours at 2°C-8°C). 
Pri 2-minutni intravenski injekciji čas shranjevanja rekonstituirane raztopine v viali (glejte poglavje 6.6) pri 25 °C ne sme presegati 12 ur (ali 48 ur pri 2 °C - 8 °C).
Daptomycin administered as a 2-minute intravenous injection also exhibited dose proportional pharmacokinetics in the approved therapeutic dose range of 4 to 6 mg/kg. 
Tudi farmakokinetika daptomicina, danega v obliki 2-minutne intravenske injekcije, je v razponu odobrenih terapevtskih odmerkov od 4 do 6 mg/kg sorazmerna z odmerkom.
Renal impairment Daptomycin is eliminated primarily by the kidney. 
Okvara ledvic Daptomicin se izloča primarno preko ledvic.
The dosage regimen for daptomycin in paediatric patients with renal impairment has not been established. 
Režim odmerjanja daptomicina pri pediatričnih bolnikih z okvaro ledvic ni bil določen.
12-17 years (N=13) 
12-17 let (N = 13)
After reconstitution: Chemical and physical in-use stability of the reconstituted solution in the vial has been demonstrated for 12 hours at 25°C and up to 48 hours at 2°C - 8°C. 
Po rekonstituciji: kemijsko in fizikalno stabilnost rekonstituirane raztopine v viali med uporabo so dokazali za 12 ur pri 25 °C in do 48 ur pri 2 °C - 8 °C.
Daptomycin pharmacokinetics are generally linear and time-independent at doses of 4 to 12 mg/kg administered as a single daily dose by 30-minute intravenous infusion for up to 14 days in healthy adult volunteers. 
Farmakokinetika daptomicina je v odmerkih od 4 do 12 mg/kg, ki so jih zdravi odrasli prostovoljci prejemali v enkratnem dnevnem odmerku s 30-minutno intravensko infuzijo do 14 dni, v splošnem linearna in neodvisna od časa.
The success rates in RIE patients are shown in the table below. 
Spodnja preglednica prikazuje stopnje uspešnosti pri bolnikih z RIE.
If you think you may be allergic, ask your doctor or nurse for advice. 
Če menite, da bi lahko bili alergični, se posvetujte z zdravnikom ali medicinsko sestro.
Less frequently reported, but more serious, adverse reactions include hypersensitivity reactions, eosinophilic pneumonia (occasionally presenting as organising pneumonia), drug rash with eosinophilia and systemic symptoms (DRESS), angioedema and rhabdomyolysis. 
Neželeni učinki, o katerih so poročali manj pogosto, a so resnejši, vključujejo preobčutljivostne reakcije, eozinofilno pljučnico (ki se občasno kaže kot organizirajoča pljučnica), z zdravilom povezan izpuščaj z eozinofilijo in sistemskimi simptomi (DRESS - Drug Reaction with Eosinophilia and Systemic Symptoms), angioedem in rabdomiolizo.
The reconstituted solution should then be injected intravenously slowly over 2 minutes. 
Rekonstituirano raztopino morate nato 2 minuti počasi intravensko injicirati.
Recurrence of eosinophilic pneumonia upon re-exposure has been reported. 
Po ponovni izpostavljenosti zdravilu so poročali o ponovitvi eozinofilne pljučnice.
Paediatric patients 7 to 17 years old should receive daptomycin infused over 30 minutes. 
Pediatričnim bolnikom, starim od 7 do 17 let, je treba daptomicin infundirati 30 minut.
Daptomycin is excreted primarily by the kidneys. 
Daptomicin se izloča primarno preko ledvic.
The reconstituted and diluted solution should then be infused intravenously over 30 or 60 minutes as directed in section 4.2. 
Rekonstituirano in razredčeno raztopino morate nato intravensko infundirati 30 ali 60 minut, kot je navedeno v poglavju 4.2.
Daptomycin Hospira should not be used more frequently than once a day. 
Zdravila Daptomycin Hospira se ne sme odmerjati več kot enkrat na dan.
Uncommon: Dyspepsia, glossitis 
dispepsija, glositis
The safety and efficacy of daptomycin was evaluated in paediatric patients aged 1 to 17 years (Study DAP-PEDBAC-11-02) with bacteraemia caused by Staphylococcus aureus. 
Varnost in učinkovitost daptomicina so ocenili pri pediatričnih bolnikih, starih od 1 do 17 let (študija DAP-PEDBAC-11-02) z bakteriemijo zaradi bakterije Staphylococcus aureus.
AUC0-∞ daptomycin was significantly increased (mean 42% higher) compared with non-obese matched controls. 
70 ml/min je bila vrednost AUC0-∞ daptomicina znatno višja (v povprečju za 42 % višja) v primerjavi s primerljivimi kontrolnimi preskušanci z normalno telesno maso.
The pharmacokinetics of daptomycin is not altered in subjects with moderate hepatic impairment (Child-Pugh B classification of hepatic impairment) compared with healthy volunteers matched for gender, age and weight following a single 4 mg/kg dose. 
Po dajanju enkratnih odmerkov 4 mg/kg se farmakokinetika daptomicina pri preskušancih z zmerno okvaro jeter (razred B po razvrstitvi okvare jeter po lestvici Child-Pugh) ni spremenila v primerjavi z zdravimi prostovoljci, primerljivimi glede na spol, starost in telesno maso.
- Known or suspected RIE due to Staphylococcus aureus: daptomycin 6mg/kg is administered once every 24 hours. 
- Dokazan RIE zaradi Staphylococcus aureus ali sum nanj: daptomicin dajemo v odmerku 6 mg/kg vsakih 24 ur.
The Marketing Authorisation Holder shall ensure that all laboratories expected to perform Daptomycin Hospira susceptibility testing are provided with: - Summary of Product Characteristics - Laboratory susceptibility testing leaflet 
Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da bodo vsi laboratoriji, ki bodo predvidoma izvajali testiranja občutljivosti, prejeli: - povzetek glavnih značilnosti zdravila, - letak za laboratorije s pojasnili glede testiranja na občutljivost.
These limitations of the patients population treated should be taken into account when deciding to use daptomycin. 
Pri odločanju o uporabi daptomicina je treba upoštevati navedene omejitve pri zdravljeni skupini bolnikov.
For the 30-minute intravenous infusion, the combined storage time (reconstituted solution in vial and diluted solution in infusion bag; see section 6.6) at 25°C must not exceed 12 hours (or 24 at 2°C-8°C). 
Pri 30-minutni intravenski infuziji skupni čas shranjevanja (rekonstituirana raztopina v viali in razredčena raztopina v infuzijski vrečki: glejte poglavje 6.6) pri 25 °C ne sme presegati 12 ur (ali 24 ur pri 2 °C - 8 °C).
Frequency not known: frequency cannot be estimated from the available data Antibacterial-associated colitis, including pseudomembranous colitis (severe or persistent diarrhoea containing blood and/or mucus, associated with abdominal pain or fever), easy bruising, bleeding gums, or nosebleeds. 
Neznana pogostnost: pogostnosti iz razpoložljivih podatkov ni mogoče oceniti Z antibiotiki povezan kolitis, vključno s psevdomembranskim kolitisom (huda ali trdovratna driska, ki vsebuje kri in/ali sluz, povezana z bolečinami v trebuhu in zvišano telesno temperaturo), hiter pojav modric, krvaveče dlesni ali krvavitve iz nosu.
A total of 81 subjects were treated in the study, including 55 subjects who received daptomycin and 26 subjects who received standard-of-care. 
V študiji je bilo zdravljenih skupno 81 bolnikov, od katerih jih je 55 prejemalo daptomicin in
After a single 4, 8, or 10 mg/kg dose of daptomycin, total clearance and elimination half-life of daptomycin in children 2-6 years of age were similar at different doses; total clearance was higher and elimination half-life was shorter than in adolescents. 
Po enkratnem odmerku 4, 8 ali 10 mg/kg daptomicina sta bila celotni očistek in eliminacijski razpolovni čas daptomicina pri otrocih v starosti od 2 do 6 let ob različnih odmerkih podobna; celotni očistek je bil večji, eliminacijski razpolovni čas pa krajši kot pri mladostnikih.
Hold the vial by the vial neck, tilt the vial and swirl vial contents until the product is completely reconstituted. 
Vialo držite za vrat, nato jo nagnite in vrtite njeno vsebino, dokler zdravilo ni popolnoma rekonstituirano.
Read the package leaflet before use. 
intravenska uporaba Pred uporabo preberite priloženo navodilo!
- Adult and paediatric (1 to 17 years of age) patients withStaphylococcus aureus bacteraemia (SAB). 
- pri odraslih in pediatričnih bolnikih (starih od 1 do 17 let) z bakteriemijo Staphylococcus aureus (SAB).
Not known*: Eosinophilic pneumonia 1**, cough 
eozinofilna pljučnica 1**, kašelj
Daptomycin Hospira is therefore not indicated for the treatment of pneumonia. 
Daptomicin zato ni indiciran za zdravljenje pljučnice.
Limb pain, serum creatine phosphokinase (CPK) increased 
bolečine v okončinah, zvišane vrednosti kreatin-fosfokinaze (CPK) v serumu občasni:
Not known*: Acute generalised exanthematous pustulosis 
akutna generalizirana eksantematozna pustuloza
The reconstituted solution should then be injected intravenously slowly over 2 minutes as directed in section 4.2. 
Rekonstituirano raztopino morate nato 2 minuti počasi intravensko injicirati, kot je navedeno v poglavju 4.2.
Uncommon: Paraesthesia, taste disorder, tremor, eye irritation Not known*: Peripheral neuropathy** 
parestezija, motnje okušanja, tremor, draženje očesa neznana pogostnost*:
Streptococcus dysgalactiae subsp equisimilis* 
Streptococcus dysgalactiae, subsp.
Daptomycin is administered intravenously in 0.9% sodium chloride (see section 6.6). 
Daptomicin dajemo intravensko v 0,9-odstotni raztopini natrijevega klorida (glejte poglavje 6.6).
RIE due to Staphylococcus aureus 
RIE zaradi bakterije Staphylococcus aureus
- cSSTI with concurrent SAB: daptomycin 6 mg/kg is administered once every 24 hours. 
- cSSTI s sočasno SAB: daptomicin dajemo v odmerku 6 mg/kg vsakih 24 ur.
Relative to non-obese subjects daptomycin systemic exposure measured by AUC was about 28% higher in moderately obese subjects (Body Mass Index of 25-40 kg/m2) and 42% higher in extremely obese subjects 
V primerjavi s preskušanci z normalno telesno maso je bila sistemska izpostavljenost daptomicinu, izmerjena kot vrednost AUC, za približno 28 % večja pri zmerno debelih preskušancih (indeks telesne mase 25-40 kg/m2) in za 42 % večja pri zelo debelih preskušancih (indeks telesne mase > 40 kg/m Vendar pa velja, da zgolj na osnovi debelosti prilagajanje odmerka ni potrebno.
It is mixed with a solvent to form a liquid before it is administered. 
Pred uporabo ga je treba zmešati z vehiklom, da nastane tekočina.
Plasma exposures achieved with these doses were consistent with those achieved in the adult cSSTI study (following 4 mg/kg once daily in adults). 
Izpostavljenost v plazmi, dosežena s temi odmerki, je bila skladna z izpostavljenostjo, doseženo v študiji zapletenih okužb kože in mehkih tkiv pri odraslih (po odmerku 4 mg/kg enkrat na dan pri odraslih).
Other medicines and Daptomycin Hospira Tell your doctor or nurse if you are taking, have recently taken or might take any other medicines. 
Obvestite zdravnika ali medicinsko sestro, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katerokoli drugo zdravilo.
Daptomycin undergoes little to no Cytochrome P450 (CYP450)-mediated metabolism. 
Preko citokroma P450 (CYP450) se daptomicin presnavlja le malo ali nič.
Clostridium difficile-associated diarrhoea (CDAD) has been reported with daptomycin (see section 4.8). 
Diareja, ki jo povzroča bakterija Clostridium difficile Pri uporabi daptomicina so poročali o diareji, ki jo povzroča bakterija Clostridium difficile (CDADClostridium difficile-associated diarrhoea) (glejte poglavje 4.8).
An adjustment of daptomycin dose interval is needed for adult patients whose creatinine clearance is <30 ml/min (see sections 4.2 and 5.2). 
Pri odraslih bolnikih z očistkom kreatinina < 30 ml/min je treba prilagoditi interval odmerjanja daptomicina (glejte poglavji 4.2 in 5.2).
Stability of the diluted solution in infusion bags is established as 12 hours at 25°C or 24 hours if stored under refrigeration at 2°C-8°C. 
Razredčena raztopina v infuzijskih vrečkah je stabilna 12 ur pri 25 °C ali 24 ur v primeru shranjevanja v hladilniku pri 2 °C - 8 °C.
After a single 6 mg/kg dose of daptomycin, the clearance and elimination half-life of daptomycin in children 13-24 months of age were similar to children 2-6 years of age who received a single 4-10 mg/kg dose. 
Po enkratnem odmerku 6 mg/kg daptomicina sta bila celotni očistek in eliminacijski razpolovni čas daptomicina pri otrocih, starih od 13 do 24 mesecev, podobna kot pri otrocih, starih od 2 do 6 let, ki so prejeli enkraten odmerek 410 mg/kg.
In adults, daptomycin may be administered intravenously as an infusion over 30 minutes or as an injection over 2 minutes. 
Pri odraslih je daptomicin mogoče aplicirati intravensko v obliki infuzije, ki traja 30 minut, ali v obliki injekcije, ki traja 2 minuti.
The duration of therapy may need to be longer than 14 days in accordance with the perceived risk of complications in the individual patient. 
Glede na pričakovano tveganje za zaplete pri posameznem bolniku je lahko trajanje zdravljenja daljše od 14 dni.