natgillin/translations-raw huggingface dataset:
In Ph+ ALL patients, there is clinical experience of co-administering imatinib with chemotherapy (see section 5.1), but drug-drug interactions between imatinib and chemotherapy regimens are not well characterised. 
obstajajo (glejte poglavje 5.1), pa interakcije med imatinibom in posameznimi kemoterapevtskimi shemami niso dobro opredeljene.
EU/1/13/825/003 24 capsules EU/1/13/825/004 48 capsules EU/1/13/825/019 60 capsules EU/1/13/825/005 96 capsules EU/1/13/825/006 120 capsules EU/1/13/825/007 180 capsules 
EU/1/13/825/003 24 kapsul EU/1/13/825/004 48 kapsul EU/1/13/825/019 60 kapsul EU/1/13/825/005 96 kapsul EU/1/13/825/006 120 kapsul EU/1/13/825/007 180 kapsul
Hard capsule of size 3 with light yellow cap and light yellow body imprinted with “50 mg” in black ink. 
Trda kapsula velikosti 3 s svetlo rumenim pokrovčkom in svetlo rumenim telesom kapsule s črnim napisom “50 mg”.
(24 h), day 1, Ara-C 1 g/m2 i.v. 
(24 ur), 1. dan, Ara-C 1 g/m2 i.v.
In addition, gastric antral vascular ectasia (GAVE), a rare cause of gastrointestinal haemorrhage, has been reported in post-marketing experience in patients with CML, ALL and other diseases (see section 4.8). 
Poleg tega so v okviru izkušenj v obdobju trženja zdravila pri bolnikih s KML, ALL in drugimi boleznimi poročali o žilnih ektazijah antruma želodca (GAVE - gastric antral vascular ectasia) redkem vzroku gastrointestinalne krvavitve (glejte poglavje 4.8).
EU/1/13/825/015 10 tablets EU/1/13/825/016 30 tablets EU/1/13/825/017 60 tablets EU/1/13/825/018 90 tablets 
EU/1/13/825/015 10 tablet EU/1/13/825/016 30 tablet EU/1/13/825/017 60 tablet EU/1/13/825/018 90 tablet
Active substances that may have their plasma concentration altered by imatinib: 
Učinkovine, katerih plazemske koncentracije lahko imatinib spremeni:
Your doctor will tell you exactly how many capsules of Imatinib Actavis to take. 
Zdravnik vam bo natančno povedal, koliko kapsul zdravila Imatinib Actavis morate jemati.
If your daily dose is 800 mg (2 tablets), you should take one tablet in the morning and a second in the evening. 
Če je vaš dnevni odmerek 800 mg (2 tableti), morate vzeti eno tableto zjutraj in drugo zvečer.
Pack sizes: The capsules are supplied in aluminium blister packs of 30 or 90 capsules. 
Kapsule so na voljo v aluminiastih pretisnih omotih, pakiranih po 30 ali 90 kapsul.
However, always take this medicine exactly as your doctor or pharmacist has told you. 
Seveda pri jemanju tega zdravila natančno upoštevajte navodila svojega zdravnika ali farmacevta.
In vivo the compound shows anti-tumour activity as a single agent in animal models using Bcr-Abl positive tumour cells. 
In vivo spojina kaže protitumorsko aktivnost, če se uporablja kot edino sredstvo, v živalskih modelih z
Each film-coated tablet contains 0.75 mg lecithin (soya) (E322) For the full list of excipients, see section 6.1. 
Ena filmsko obložena tableta vsebuje 0,75 mg sojin lecitin (E322).
Iron oxide yellow (E172) Titanium dioxide (E171) Iron oxide red (E172) Lecithin (soya) (E322) Xanthan gum (E415) 
(E171), rdeči železov oksid (E172), sojin lecitin (E322), ksantanski gumi (E415).
In the 2-year rat carcinogenicity study administration of imatinib at 15, 30 and 60 mg/kg/day resulted in a statistically significant reduction in the longevity of males at 60 mg/kg/day and females at ≥ 30 mg/kg/day. 
60 mg/kg/dan povzročilo statistično značilno skrajšanje življenjske dobe samcev pri 60 mg/kg/dan in samic pri ≥ 30 mg/kg/dan.
Daunorubicin 30 mg/m2 i.v., days 1-3, 15-16; VCR 2 mg total dose i.v., days 1, 8, 15, 22; CP 750 mg/m2 i.v., days 1, 8; prednisone 60 mg/m2 oral, days 1-7, 15-21; IDA 9 mg/m2 oral, days 1-28; MTX 
VCR skupni odmerek 2 mg i.v., 1., 8., 15., 22. dan; CP 750 mg/m2 i.v., 1., 8. dan; prednizon 60 mg/m2 peroralno, 1.-7., 15.-21. dan; IDA 9 mg/m2 peroralno, 1.-28. dan;
EU/1/13/825/008 10 tablets EU/1/13/825/009 20 tablets EU/1/13/825/010 30 tablets EU/1/13/825/011 60 tablets EU/1/13/825/012 90 tablets EU/1/13/825/013 120 tablets EU/1/13/825/014 180 tablets 
EU/1/13/825/008 10 tablet EU/1/13/825/009 20 tablet EU/1/13/825/010 30 tablet EU/1/13/825/011 60 tablet EU/1/13/825/012 90 tablet EU/1/13/825/013 120 tablet EU/1/13/825/014 180 tablet
8 Some fatal cases of hepatic failure and of hepatic necrosis have been reported. 
8 Poročali so o nekaj primerih odpovedi jeter in nekroze jeter s smrtnim izidom.
ANC < 1.0 x 109/L and/or platelets < 50 x 109/L 
ANC < 1,0 x 109/l in/ali koncentracija trombocitov < 50 x 109/l
Triple IT therapy (age-adjusted): days 1 and 22 
zdravljenje (prilagojeno na starost): 8. in 15. dan
Imatinib Actavis 100 mg film-coated tablets Each film-coated tablet contains 100 mg imatinib (as mesilate). 
Imatinib Actavis 100 mg filmsko obložene tablete Ena filmsko obložena tableta vsebuje 100 mg imatiniba (v obliki mesilata).
- Pelvic pain sometimes with nausea and vomiting, with unexpected vaginal bleeding, feeling dizzy or fainting due to low blood pressure (signs of problems with your ovaries or womb). 
- bolečine v medenici, včasih z občutkom slabosti s siljenjem na bruhanje in bruhanjem, z nepričakovano krvavitvijo iz nožnice, omotičnost ali izguba zavesti zaradi nizkega krvnega tlaka (znaki težav z jajčniki ali maternico),
How to take Imatinib Actavis 
Kako jemati zdravilo Imatinib Actavis
Caution should be used when taking imatinib with protease inhibitors, azole antifungals, certain macrolides (see section 4.5), CYP3A4 substrates with a narrow therapeutic window (e.g. cyclosporine, pimozide, tacrolimus, sirolimus, ergotamine, diergotamine, fentanyl, alfentanil, terfenadine, bortezomib, docetaxel, quinidine) or warfarin and other coumarin derivatives (see section 4.5). 
Previdnost je potrebna pri uporabi imatiniba z zaviralci proteaze, anolnimi antimikotiki, določenimi makrolidi (glejte poglavje 4.5), s substrati CYP3A4 z ozkim terapevtskim oknom (na primer s ciklosporinom, pimozidom, takrolimusom, sirolimusom, ergotaminom, diergotaminom, fentanilom, alfentanilom, terfenadinom, bortezomibom, docetakselom, kinidinom) ali z varfarinom in drugimi derivati kumarina (glejte poglavje 4.5).
EU/1/13/825/020 10 capsules EU/1/13/825/021 30 capsules EU/1/13/825/022 60 capsules EU/1/13/825/023 90 capsules 
EU/1/13/825/020 10 kapsul EU/1/13/825/021 30 kapsul EU/1/13/825/022 60 kapsul EU/1/13/825/023 90 kapsul
The dose is 800 mg per day (2 capsules), to be taken as one capsule in the morning and a second capsule in the evening. 
Odmerek je 800 mg na dan (2 kapsuli), ki ga vzamete kot eno kapsulo zjutraj in drugo kapsulo zvečer.
If your daily dose is 800 mg (8 tablets), you should take 4 tablets in the morning and 4 tablets in the evening. 
Če je vaš dnevni odmerek 800 mg (8 tablet), morate vzeti 4 tablete zjutraj in 4 tablete zvečer.
Pack sizes: The capsules are supplied in aluminium blister packs of 10, 30, 60, or 90 capsules. 
Kapsule so na voljo v aluminiastih pretisnih omotih, pakiranih po 10, 30, 60 ali 90 kapsul.
Imatinib Actavis 50 mg hard capsules Al/PVC/Aclar blister. 
Imatinib Actavis 50 mg trde kapsule Pretisni omoti iz Al/PVC/Aclar.
Liver dysfunction 
Disfunkcija jeter
(24 h), days 1, 15; 6-MP 25 mg/m2 oral, days 1-20 
(24 ur), 1., 15. dan; 6-MP 25 mg/m2 peroralno, 1.-20. dan konsolidacijska terapija II, IV
Evaluation by a cardiology specialist, performance of an echocardiogram and determination of serum troponin should therefore be considered in patients with HES/CEL, and in patients with MDS/MPD associated with high eosinophil levels before imatinib is administered. 
Zato je pri bolnikih s HES/CEL in bolnikih z velikimi koncentracijami eozinofilcev v povezavi z MDS/MPD pred uporabo imatiniba potrebno razmisliti o pregledu pri specialistu kardiologu, izvedbi ehokardiograma in določitvi serumskega troponina.
Imatinib Actavis 400 mg hard capsules Al/PVC-PVDC blister. 
Imatinib Actavis 400 mg trde kapsule Pretisni omoti iz Al/PVC/PVDC.
The adult patients reported in the published literature were treated with either 400 mg (4 cases) or 800 mg (1 case) imatinib daily. 
Odrasli bolniki, o katerih so pisali v objavljeni literaturi, so bili zdravljeni z odmerki bodisi 400 mg (v 4 primerih) ali pa 800 mg (v 1 primeru) zdravila Imatinib Actavis na dan. Do odziva je prišlo pri petih (5) bolnikih, pri 3 do popolnega in pri 2 do delnega.
Resume treatment with imatinib at previous dose (i.e. before severe adverse reaction). 
Spet začnite zdravljenje z zdravilom imatinibom s prejšnjim odmerkom (t.j.
Hard capsule of size 1 with light orange cap and light orange body imprinted with “100 mg” in black ink. 
Trda kapsula velikosti 1 s svetlo oranžnim pokrovčkom in svetlo oranžnim telesom kapsule s črnim napisom “100 mg”.
(3 h), days 1-4; mitoxantrone 10 mg/m2 i.v. 
(3 ure), 1.-4. dan; mitoksantron 10 mg/m2 i.v.
Induction therapy II CP 1 g/m2 i.v. 
Dan indukcijsko zdravljenje II CP 1 g/m2 i.v.
If your daily dose is 800 mg (2 capsules), you should take one capsule in the morning and a second capsule in the evening. 
Če je vaš dnevni odmerek 800 mg (2 kapsuli), morate vzeti eno kapsulo zjutraj in drugo kapsulo zvečer.
Herpes zoster, herpes simplex, nasopharyngitis, pneumonia1, sinusitis, cellulitis, upper respiratory tract infection, influenza, urinary tract infection, gastroenteritis, sepsis 
Preglednica 1 Preglednica neželenih učinkov Infekcijske in parazitske bolezni občasni herpes zoster, herpes simpleks, nazofaringitis, pljučnica1, sinuzitis, flegmona, okužba zgornjih dihal, gripa, okužba sečil, gastroenteritis, sepsa redki glivične okužbe
Imatinib Actavis 100 mg hard capsules Al/PVC/Aclar blister. 
Imatinib Actavis 100 mg trde kapsule Pretisni omoti iz Al/PVC/Aclar.
The dose is 800 mg per day (2 tablets), to be taken as one tablet in the morning and a second tablet in the evening. 
Odmerek je 800 mg na dan (2 tableti), ki ga vzamete kot 1 tableto zjutraj in eno tableto zvečer.
- Pain or swelling in your abdomen, flatulence, heartburn or constipation. 
- bolečine v trebuhu ali napihnjen trebuh, vetrovi, zgaga ali zapeka,
OTHER 
In
In the study in patients with unresectable and/or metastatic GIST, grade 3 and 4 anaemia was reported in 5.4% and 0.7% of patients, respectively, and may have been related to gastrointestinal or intratumoural bleeding in at least some of these patients. 
V študiji pri bolnikih z neresektabilnimi in/ali metastatskimi GIST so poročali o anemiji 3. in 4. stopnje pri 5,4 % oziroma 0,7 % bolnikov.
For doses of 400 mg and above (see dosage recommendation above) a 400 mg tablet (not divisible) is available. 
Način uporabe Za odmerke 400 mg in več (glejte zgoraj navedeno priporočeno odmerjanje) so na voljo tablete
- Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph-positive ALL). 
- akutno limfoblastno levkemijo s prisotnim kromosomom Philadelphia (Ph pozitivna ALL).
CML in blast crisis and Ph+ ALL (starting dose 600 mg) 
Ph+ ALL (začetni odmerek 600 mg)
Therefore, caution is recommended when administering imatinib with CYP3A4 substrates with a narrow therapeutic window (e.g. cyclosporine, pimozide, tacrolimus, sirolimus, ergotamine, diergotamine, fentanyl, alfentanil, terfenadine, bortezomib, docetaxel and quinidine). 
Zato je pri uporabi imatiniba skupaj s substrati CYP3A4 z ozko terapevtsko širino (na primer s ciklosporinom, pimozidom, takrolimusom, sirolimusom, ergotaminom, diergotaminom, fentanilom, alfentanilom, terfenadinom, bortezomibom, docetakselom in kinidinom) priporočljiva previdnost.
(q 12 h), days 2-3, for 
(na 12 ur), 2.-3.
The dose is 800 mg per day (8 tablets), to be taken as 4 tablets in the morning and 4 tablets in the evening. 
Odmerek je 800 mg na dan (8 tablet), ki ga vzamete kot 4 tablete zjutraj in 4 tablete zvečer.
Imatinib Actavis 50 mg hard capsules Imatinib Actavis 100 mg hard capsules Imatinib Actavis 400 mg hard capsules 
Imatinib Actavis 50 mg trde kapsule Imatinib Actavis 100 mg trde kapsule Imatinib Actavis 400 mg trde kapsule
Posology for DFSP The recommended dose of imatinib is 800 mg/day for adult patients with DFSP. 
Priporočeni odmerek zdravila Imatinib Actavis pri odraslih bolnikih s DFSP je 800 mg/dan.
(1 h), days 28-31, 35-38, 42-45; 6-MP 60 mg/m2 oral, days 26-46 
(1 ura), 28.-31., 35.-38., 42.-45.
Induction therapy CP 1.2 g/m2 i.v. 
indukcijsko zdravljenje CP 1,2 g/m2 i.v.
(24 h), day 1; etoposide 250 mg/m2 i.v. 
(24 ur), 1. dan; etopozid 250 mg/m2 i.v.
- Bruising. 
- srbenje,
Blood creatinine increased, blood creatine phosphokinase increased, blood lactate dehydrogenase increased, blood alkaline phosphatase increased 
Preiskave zelo pogosti zvečanje telesne mase pogosti zmanjšanje telesne mase občasni zvišana vrednost kreatinina v krvi, zvišana vrednost kreatin-kinaze v krvi, zvišana vrednost laktat-dehidrogenaze v krvi, zvišana vrednost alkalne fosfataze v krvi redki zvišana vrednost amilaze v krvi
Pack sizes: The tablets are supplied in aluminium blister packs of 10, 30, 60 or 90 film-coated tablets. 
Tablete so na voljo v aluminiastih pretisnih omotih, pakiranih po 10, 30, 60 ali 90 filmsko obloženih tablet.
Papilloma/carcinoma of the preputial/clitoral gland were noted from 30 mg/kg/day onwards, representing approximately 0.5 or 0.3 times the human daily exposure (based on AUC) at 400 mg/day or 800 mg/day, respectively, and 0.4 times the daily exposure in children (based on AUC) at 340 mg/m2/day. 
Papilome/karcinome prepucijske/klitorisne žleze so opazili pri odmerkih od 30 mg/kg/dan naprej, kar predstavlja približno 0,5-kratnik oziroma 0,3-kratnik dnevne izpostavljenosti človeka (na podlagi
Imatinib Actavis 100 mg film-coated tablets Imatinib Actavis 400 mg film-coated tablets 
Imatinib Actavis 100 mg filmsko obložene tablete Imatinib Actavis 400 mg filmsko obložene tablete
Caution should be taken when administering imatinib with inhibitors of the CYP3A4 family. 
Pri uporabi imatiniba z zaviralci skupine CYP3A4 je potrebna previdnost.
Imatinib Actavis contains lecithin (soya) 
Zdravilo Imatinib Actavis vsebuje sojin lecitin
Printing ink: shellac, black iron oxide (E172), propylene glycol, ammonia solution, potassium hydroxide. 
Tiskarska barva: šelak, črni železov oksid (E172), propilenglikol, raztopina amonijaka, kalijev hidroksid.
days 3-5; MTX 15 mg intrathecal, day 1; methylprednisolone 40 mg intrathecal, day 1 
MTX 15 mg intratekalno, 1.dan; metilprednizolon 40 mg intratekalno, 1. dan
The dose is 800 mg per day (8 capsules), to be taken as 4 capsules in the morning and 4 capsules in the evening. 
Odmerek je 800 mg na dan (8 kapsul), ki ga vzamete kot 4 kapsule zjutraj in 4 kapsule zvečer.
VP-16 (100 mg/m2/day, IV): days 1-5 
VP-16 (100 mg/m2/dan, i.v.
(24 h), day 1, and Ara-C 2 g/m2 i.v. 
(24 ur), 1.dan in Ara-C 2 g/m2 i.v.
Imatinib Actavis 400 mg film-coated tablets EU/1/13/825/015 
Imatinib Actavis 400 mg filmsko obložene tablete EU/1/13/825/015
Round, 9.2 mm in diameter, biconvex dark yellow to brownish film-coated tablet, embossed with company logo on one side and “36” with score line on the other side. 
Okrogla, premera 9,2 mm, temno rumena do rjavkastooranžna bikonveksna filmsko obložena tableta, natisnjena z logotipom podjetja na eni strani in “36” z zarezo na drugi strani.
Remission induction DEX 10 mg/m2 oral, days 6-7, 13-16; VCR 1 mg i.v., days 7, 14; IDA 8 mg/m2 i.v. 
DEX 10 mg/m2 peroralno, 6.-7., 13.-16. dan; VCR 1 mg i.v., 7. in 14. dan;
(1 h) day 1; AraC 60 mg/m2 i.v., days 22-25, 29-32 
Ara-C 60 mg/m2 i.v., 22.-25., 29.-32.
BM = bone marrow, PB = peripheral blood 
PB, brez bolezni zunaj kostnega mozga, razen v vranici in jetrih BM = kostni mozeg, PB = periferna kri
Rash pustular, contusion, sweating increased, urticaria, ecchymosis, increased tendency to bruise, hypotrichosis, skin hypopigmentation, dermatitis exfoliative, onychoclasis, folliculitis, petechiae, psoriasis, purpura, skin hyperpigmentation, bullous eruptions 
nagnjenost k podplutbam, hipotrihoza, hipopigmentacija kože, eksfoliativni dermatitis, lomljenje nohtov, folikulitis, petehije, psoriaza, purpura, hiperpigmentacija kože, bulozne erupcije redki akutna febrilna nevtrofilna dermatoza (Sweetov sindrom), sprememba barve nohtov, angionevrotični edem, mehurčkast izpuščaj, multiformni eritem,
If tolerated, the dose can be increased for lack of efficacy (see sections 4.4 and 5.2). 
Če bolnik odmerek dobro prenaša, ga je mogoče v primeru nezadostnega učinka povečati (glejte poglavji 4.4 in
If your daily dose is 800 mg (16 capsules), you should take 8 capsules in the morning and 8 capsules in the evening. 
Če je vaš dnevni odmerek 800 mg (16 kapsul), morate vzeti 8 kapsul zjutraj in 8 kapsul zvečer.
Imatinib Actavis 100 mg film-coated tablets EU/1/13/825/008 
Imatinib Actavis 100 mg filmsko obložene tablete EU/1/13/825/008
If cytopenia is unrelated to leukaemia, reduce dose of imatinib to 260 mg/m2. 
zmanjšajte odmerek imatiniba na 260 mg/m2.
Oval-shape, biconvex dark yellow to brownish film-coated tablet, embossed with company logo on one side and “37” with score line on the other side. 
Ovalne oblike, temno rumena do rjavkastooranžna bikonveksna filmsko obložena tableta, natisnjena z logotipom podjetja na eni strani in “37” z zarezo na drugi strani.
The dose is 800 mg per day (16 capsules), to be taken as 8 capsules in the morning and 8 capsules in the evening. 
Odmerek je 800 mg na dan (16 kapsul), ki ga vzamete kot 8 kapsul zjutraj in 8 kapsul zvečer.
Imatinib Actavis contains sodium 
Zdravilo Imatinib Actavis vsebuje natrij
Triple IT therapy (age-adjusted): day 1 
metotreksat (prilagojen na starost): SAMO 1. dan trojno i.t.
Gynaecomastia, erectile dysfunction, menorrhagia, menstruation irregular, sexual dysfunction, nipple pain, breast enlargement, scrotal oedema 
Motnje reprodukcije in dojk občasni ginekomastija, erektilna disfunkcija, menoragija, neredne menstrualne krvavitve, motnje spolnih funkcij, boleče bradavice, povečanje dojk, edem skrotuma redki krvavitev v rumeno telesce/krvavitev v ovarijsko cisto
Imatinib Actavis 400 mg hard capsules Each hard capsule contains 400 mg imatinib (as mesilate). 
Imatinib Actavis 400 mg trde kapsule Ena kapsula vsebuje 400 mg imatiniba (v obliki mesilata).
Round, biconvex dark yellow to brownish film-coated tablet, embossed with company logo on one side and “36” with score line on the other side. 
Okrogla, temno rumena do rjavkastooranžna bikonveksna filmsko obložena tableta, natisnjena z logotipom podjetja na eni strani in “36” z zarezo na drugi strani.
The starting dose is 100 mg, to be taken as 2 capsules once a day. 
Začetni odmerek je 100 mg, ki ga vzamete kot 2 kapsuli enkrat na dan.
Oval-shape, 18.6x6.6 mm, biconvex dark yellow to brownish film-coated tablet, embossed with company logo on one side and “37” with score line on the other side. 
Imatinib Actavis 400 mg filmsko obložene tablete Ovalne oblike, velikosti 18,6x6,6 mm, temno rumena do rjavkastooranžna bikonveksna filmsko obložena tableta, natisnjena z logotipom podjetja na eni strani in “37” z zarezo na drugi strani.
Imatinib Actavis 400 mg hard capsules EU/1/13/825/020 
Imatinib Actavis 400 mg trde kapsule EU/1/13/825/020
Imatinib Actavis 50 mg hard capsules EU/1/13/825/001 
Imatinib Actavis 50 mg trde kapsule EU/1/13/825/001
If any of these affect you severely, tell your doctor. 
Če se pri vas kateri od zgoraj navedenih neželenih učinkov pojavi v hujši obliki, obvestite zdravnika.
Excipients 
ciklusih
Plasma pharmacokinetics 
Farmakokinetika imatiniba
The usual starting dose is 600 mg to be taken as one capsule of 400 mg plus 2 capsules of 100 mg once a day. 
Običajni začetni odmerek je 600 mg, ki se vzame kot eno 400 mg kapsulo plus dve 100 mg kapsuli enkrat na dan.
Hypokalaemia, increased appetite, hypophosphataemia, decreased appetite, dehydration, gout, hyperuricaemia, hypercalcaemia, hyperglycaemia, hyponatraemia 
protin, hiperurikemija, hiperkalciemija, hiperglikemija, hiponatriemija redki hiperkaliemija, hipomagneziemija
Clinical studies in Ph+ ALL 
Odmerjanje pri Ph+ ALL pri otrocih
Handling of opened capsules by women of child-bearing potential Since studies in animals have shown reproductive toxicity, and the potential risk for the human foetus is unknown, women of child-bearing potential who open capsules should be advised to handle the contents with caution and avoid skin-eye contact or inhalation (see section 4.6). 
potencialno tveganje za človeški plod pa je neznano, je treba ženskam v rodni dobi svetovati, naj pri odpiranju kapsul pazljivo ravnajo z vsebino in se izogibajo stiku zdravila z očmi preko rok ali vdihavanju zdravila (glejte poglavje 4.6).
Posology for HES/CEL The recommended dose of imatinib is 100 mg/day for adult patients with HES/CEL. 
Priporočeni odmerek zdravila Imatinib Actavis pri odraslih bolnikih s HES/CEL je 100 mg/dan.
Capsule shell: hypromellose, titanium dioxide (E171), yellow iron oxide (E172). 
Ovojnica kapsule: hipromeloza, titanov dioksid (E171), rumeni železov oksid (E172).
The starting dose is 400 mg to be taken as 4 capsules once a day. 
Začetni odmerek je 400 mg, ki ga vzamete kot 4 kapsule enkrat na dan.
The starting dose is 100 mg, to be taken as one tablet of 100 mg once a day. 
Začetni odmerek je 100 mg, ki ga vzamete kot eno 100 mg tableto enkrat na dan.
Migraine, somnolence, syncope, peripheral neuropathy, memory impairment, sciatica, restless leg syndrome, tremor, cerebral haemorrhage 
pogosti omotica, parestezije, motnje okušanja, hipestezije občasni migrena, somnolenca, sinkopa, periferna nevropatija, motnje spomina, išias, sindrom nemirnih nog, tremor, možganska krvavitev redki zvišan intrakranialni tlak, konvulzije, optični nevritis pogostnost neznana: možganski edem*
If you have accidentally taken too many capsules, talk to your doctor straight away. 
Če ste vzeli večji odmerek zdravila Imatinib Actavis, kot bi smeli Če ste pomotoma vzeli preveč kapsul, se nemudoma posvetujte s svojim zdravnikom.
Methotrexate (20 mg/m2/week, PO): days 8, 15, 22, 29, 36, 43, 50 
metotreksat (20 mg/m2/teden, peroralno): 8., 15., 22., 29., 36., 43. in 50. dan vzdrževalno zdravljenje (8-tedenski ciklusi) 6.-12. ciklus
Imatinib Actavis 50 mg hard capsules Each hard capsule contains 50 mg imatinib (as mesilate). 
Imatinib Actavis 50 mg trde kapsule Ena kapsula vsebuje 50 mg imatiniba (v obliki mesilata).
Each film-coated tablet contains 100 mg of imatinib (as mesilate). 
Ena filmsko obložena tableta vsebuje 100 mg imatiniba (v obliki mesilata).
The usual starting dose is 600 mg to be taken as 6 tablets once a day. 
Običajni začetni odmerek je 600 mg, ki se vzame kot 6 tablet enkrat na dan.
- Painful and/or blistering skin lesions - Slowing of growth in children and adolescents. 
- rdečina in/ali otekanje dlani in podplatov, lahko z občutkom mravljinčenja in s pekočo bolečino, - boleče spremembe na koži z ali brez nastanka mehurjev, - upočasnjena rast pri otrocih in mladostnikih.
Ileus/intestinal obstruction*, gastrointestinal perforation*, diverticulitis*, gastric antral vascular ectasia (GAVE)* 
pankreatitis redki kolitis, ileus, vnetna bolezen črevesa pogostnost neznana: ileus/zapora črevesja*, gastrointestinalna perforacija*, divertikulitis*, žilne ektazije antruma želodca (GAVE)*
and/or platelets < 10 x 109/L 
9/l in/ali koncentracija trombocitov < 10 x 109/l
The starting dose is 400 mg, to be taken as 8 capsules once a day. 
Začetni odmerek je 400 mg, ki ga vzamete kot 8 kapsul enkrat na dan.
In the event of recurrence of ANC < 1.0 x 109/L and/or platelets < 50 x 109/L, repeat step 1 and resume imatinib at reduced dose of 260 mg/m2. 
Če se pojav/a ANC < 1,0 x 109/l in/ali koncentracija trombocitov < 50 x 109/l ponovi/ta, ponovite točko 1 in spet začnite zdravljenje z imatinibom z zmanjšanim odmerkom 260 mg/m2.
Severe elevation of transaminases (<5%) or bilirubin (<1%) was seen in CML patients and was usually managed with dose reduction or interruption (the median duration of these episodes was approximately one week). 
Navadno so to urejali z zmanjšanjem odmerka ali s prekinitvijo zdravljenja (mediano trajanje teh epizod je bilo približno en teden).
The starting dose is 400 mg to be taken as 4 tablets once a day. 
Začetni odmerek je 400 mg, ki ga vzamete kot 4 tablete enkrat na dan.
Imatinib Actavis 100 mg hard capsules Each hard capsule contains 100 mg imatinib (as mesilate). 
Imatinib Actavis 100 mg trde kapsule Ena kapsula vsebuje 100 mg imatiniba (v obliki mesilata).