natgillin/translations-raw huggingface dataset:
Patients with rare hereditary problems of fructose intolerance, galactose intolerance, the Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicinal product. 
Bolniki z redko dedno intoleranco za fruktozo, intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze, malabsorpcijo glukoze/galaktoze ali insuficienco saharaze-izomaltaze ne smejo jemati tega zdravila.
• FIT 1: A three-year study of 2,027 patients who had at least one baseline vertebral (compression) fracture. 
• FIT 1: Triletna študija pri 2.027 bolnicah, ki so imele ob začetku študije vsaj en (kompresijski) zlom vretenca.
Therefore, caution should be used when these medicines are taken at the same time as VANTAVO. 
Zato je potrebna previdnost, kadar ta zdravila uporabljate istočasno kot zdravilo VANTAVO.
As well as your treatment with VANTAVO, your doctor may suggest you make changes to your lifestyle to help your condition, such as: 
Poleg zdravljenja z zdravilom VANTAVO vam zdravnik lahko svetuje nekaj sprememb v načinu življenja, ki pomagajo pri vaši bolezni.
However, there have been rare reports of symptomatic hypocalcaemia, which have occasionally been severe and often occurred in patients with predisposing conditions (e.g. hypoparathyroidism, vitamin D deficiency and calcium malabsorption) (see section 4.8). 
Obstajajo pa redka poročila o simptomatski hipokalciemiji, ki je bila občasno huda in do katere je pogosto prišlo pri bolnikih s predisponirajočimi motnjami (npr. hipoparatiroidizem, pomanjkanje vitamina D in malabsorpcija kalcija) (glejte poglavje 4.8).
If left untreated, however, it can result in broken bones. 
Če se je ne zdravi, lahko povzroči zlome kosti.
Urine and serum calcium should be monitored in these patients. 
Pri teh bolnikih je treba nadzorovati kalcij v urinu in serumu.
In studies, rats given high doses showed an increased incidence of incomplete foetal ossification. 
Študije na podganah, ki so prejemale velike odmerke, so pokazale zvišano pojavnost nepopolne osifikacije pri plodu.
Stopping smoking Smoking appears to increase the rate at which you lose bone and, therefore, may increase your risk of broken bones. 
Kaže, da kajenje poveča hitrost, s katero izgubljate kostno maso in zato povečuje tveganje za zlome.
The following instructions should be followed exactly in order to minimise the risk of oesophageal irritation and related adverse reactions (see section 4.4): 
Dosledno je treba upoštevati naslednja navodila, da se zmanjša tveganje za draženje požiralnika in s tem povezane neželene učinke (glejte poglavje 4.4):
Osteonecrosis of the jaw, generally associated with tooth extraction and/or local infection (including osteomyelitis), has been reported in patients with cancer who are receiving treatment regimens including primarily intravenously administered bisphosphonates. 
O osteonekrozi čeljusti, navadno povezani z ekstrakcijo zoba in /ali lokalno okužbo (vključno z osteomielitisom), so poročali pri bolnikih z rakom, ki so kot del zdravljenja prejemali predvsem intravensko aplicirane bisfosfonate.
Eating a balanced diet Your doctor can advise you about your diet or whether you should take any dietary supplements. 
Uravnotežena prehrana Zdravnik vam lahko svetuje o prehrani ali morebitni uporabi prehranskih dodatkov.
Do not make yourself vomit, and do not lie down. 
Ne smete izzvati bruhanja in ne smete se uleči.
Preclinical studies show that alendronate that is not deposited in bone is rapidly excreted in the urine. 
Predklinične študije kažejo, da se alendronat, ki se ne odlaga v kosti, hitro izloči z urinom.
In patients with known Barrett's oesophagus, prescribers should consider the benefits and potential risks of alendronate on an individual patient basis. 
Pri bolnikih z Barrettovim požiralnikom morajo zdravniki pretehtati koristi in možna tveganja alendronata pri vsakem bolniku posebej.
Osteonecrosis of the external auditory canal 
Osteonekroza zunanjega slušnega kanala
Contact your doctor if you experience pain, weakness or discomfort in your thigh, hip or groin as this may be an early indication of a possible fracture of the thigh bone, 
Posvetujte se z zdravnikom, če občutite bolečine, šibkost ali nelagodje v stegnu, kolku ali dimljah, saj so to lahko zgodnji znaki možnega zloma stegnenice.
• have been told you have trouble absorbing minerals in your stomach or intestines 
• če so vam povedali, da imate težave z absorpcijo mineralov v želodcu ali črevesju (sindrom malabsorpcije),
Although these usually hurt, breaks in the bones of the spine may go unnoticed until they cause height loss. 
Kljub temu, da so zlomi običajno boleči, pa se zgodi, da se zlomov hrbtenice ne opazi, vse dokler ne povzročijo zmanjšanja telesne višine.
The risk of severe oesophageal adverse reactions appears to be greater in patients who fail to take alendronate properly and/or who continue to take alendronate after developing symptoms suggestive of oesophageal irritation. 
Kaže, da je tveganje za resne neželene učinke v požiralniku večje pri bolnikih, ki alendronata ne jemljejo pravilno in/ali nadaljujejo z jemanjem tudi po pojavu simptomov, ki kažejo na razdraženost požiralnika.
It is important that you take VANTAVO for as long as your doctor prescribes the medicine. 
Pomembno je, da zdravilo VANTAVO jemljete tako dolgo, kot vam je predpisal zdravnik.
Rare hypersensitivity reactions including urticaria and angioedema 
Redki preobčutljivostne reakcije, vključno s koprivnico in angioedemom
Concentrations of alendronate in plasma following therapeutic oral doses are too low for analytical detection (< 5 ng/ml). 
Plazemske koncentracije alendronata po peroralnih terapevtskih odmerkih so za analitsko določitev prenizke (< 5 ng/ml).
Due to the positive effects of alendronate in increasing bone mineral, decreases in serum calcium and phosphate may occur especially in patients taking glucocorticoids in whom calcium absorption may be decreased. 
Ker ima alendronat pozitiven vpliv na povečanje mineralov v kosteh, se lahko pojavijo znižanja serumskega kalcija in fosfata, predvsem pri bolnikih, ki jemljejo glukokortikoide in imajo lahko zmanjšano absorpcijo kalcija.
There are no or limited amount of data from the use of alendronate in pregnant women. 
Podatkov o uporabi alendronata pri nosečnicah ni oziroma jih je malo.
Alendronate prevents the loss of bone that occurs in women after they have been through the menopause, and helps to rebuild bone. 
Alendronat preprečuje izgubo kostne mase, do katere pride pri ženskah po menopavzi, in pomaga pri ponovni gradnji kosti.
These could be signs of bone damage in the jaw (osteonecrosis) generally associated with delayed healing and infection, often following tooth extraction. 
To so lahko znaki poškodbe čeljustne kosti (osteonekroze), ki je običajno povezana z zapoznelim zdravljenjem in okužbo, ki se pogosto pojavi po izdrtju zoba.
Remember, take VANTAVO once each week on that same day for as long as your doctor prescribes it. 
Zapomnite si - zdravilo VANTAVO je treba vzeti le enkrat na teden, vedno na isti dan v tednu, tako dolgo, kot vam ga je predpisal zdravnik.
Choose the day of the week that best fits your schedule. 
Izberite dan v tednu, ki vam najbolj ustreza.
200 ml) , so that VANTAVO is adequately absorbed. 
(in ne manj kot 200 ml), da se zdravilo VANTAVO zadostno absorbira.
• taste disturbance. 
• motnje okusa
• symptoms of low blood calcium levels including muscle cramps or spasms and/or tingling sensation in the fingers or around the mouth, 
• simptomi nizke ravni kalcija v krvi, vključno z mišičnimi krči ali spazmom in/ali mravljinčenjem v prstih ali okrog ust
When radioactive vitamin D3 was administered to healthy subjects, the mean urinary excretion of radioactivity after 48 hours was 2.4 %, and the mean faecal excretion of radioactivity after 4 days was 4.9 %. 
Pri zdravih preiskovancih, ki so dobili radioaktivni vitamin D3, se je z urinom po 48 urah izločilo povprečno 2,4 % radioaktivnosti, povprečno izločanje radioaktivnosti z blatom po 4 dneh pa je bilo 4,9 %.
For patients who develop osteonecrosis of the jaw while on bisphosphonate therapy, dental surgery may exacerbate the condition. 
Bolnikom, pri katerih med zdravljenjem z bisfosfonati pride do osteonekroze čeljusti, lahko zobozdravniški kirurški poseg stanje še poslabša.
Following absorption, vitamin D3 enters the blood as part of chylomicrons. 
Po absorpciji vitamin D3 vstopi v kri kot del hilomikronov.
In a clinical study of healthy adults a 4,000 IU daily dose of vitamin D3 for up to five months was not associated with hypercalciuria or hypercalcaemia. 
V klinični študiji pri zdravih odraslih vitamin D3, ki so ga preiskovanci jemali do 5 mesecev v odmerku 4.000 i.e. dnevno, ni bil povezan s hiperkalciurijo ali hiperkalciemijo.
Frequency in Clinical Trials was similar in the medicinal product and placebo group. 
V kliničnih preskušanjih je bila pogostnost v skupini, ki je prejemala zdravilo, podobna kot v skupini, ki je prejemala placebo.
However, the incidences of decreases in serum calcium to < 8.0 mg/dl (2.0 mmol/l) and serum phosphate to  2.0 mg/dl (0.65 mmol/l) were similar in both treatment groups. 
Pojavnosti znižanja serumskega kalcija na < 8,0 mg/dl (2,0 mmol/l) in serumskega fosfata na ≤ 2,0 mg/dl (0,65 mmol/l) pa sta bili v obeh skupinah podobni.
Vitamin D3 may increase the magnitude of hypercalcaemia and/or hypercalciuria when administered to patients with disease associated with unregulated overproduction of calcitriol (e.g. leukaemia, lymphoma, sarcoidosis). 
Vitamin D3 lahko poveča hiperkalciemijo in/ali hiperkalciurijo, če ga jemljejo bolniki z boleznimi, povezanimi z neuravnoteženim prekomernim izločanjem kalcitriola (npr. levkemijo, limfomom, sarkoidozo).
• unusual fracture of the thigh bone particularly in patients on long-term treatment for osteoporosis may occur rarely. 
• redko se lahko pojavijo neobičajni zlomi stegnenice, še posebno pri bolnikih, ki so na dolgotrajnem zdravljenju osteoporoze.
As we get older our skin makes less vitamin D. Too little vitamin D may lead to bone loss and osteoporosis. 
S staranjem tvori naša koža manj vitamina D. Pomanjkanje vitamina D lahko vodi v izgubo kostnine in osteoporozo.
Osteoporosis is defined as bone mineral density (BMD) of the spine or hip 2.5 standard deviations (SD) below the mean value of a normal young population or as a previous fragility fracture, irrespective of BMD. 
Osteoporoza je opredeljena z zmanjšanjem mineralne kostne gostote (MKG) hrbtenice ali kolka za 2,5 standardni deviaciji (SD) pod povprečje za normalno mlado populacijo ali populacijo s predhodnimi zlomi krhkih kosti ne glede na MKG.
5) If you develop difficulty or pain upon swallowing, chest pain, or new or worsening heartburn, stop taking VANTAVO and contact your doctor. 
5) Če se pojavijo težave ali bolečine pri požiranju, bolečine v prsih, zgaga ali če se težave z zgago stopnjujejo, prenehajte jemati zdravilo VANTAVO in se posvetujte z zdravnikom.
The impact of variables such as time between cessation of bisphosphonate therapy to conception, the particular bisphosphonate used, and the route of administration (intravenous versus oral) on the risk has not been studied. 
Vpliva spremenljivk, kot so čas od prenehanja zdravljenja z bisfosfonati do zanositve, kateri bisfosfonat se jemlje ter način uporabe (intravenska oz. peroralna), na tveganje niso preučevali.
What VANTAVO is and what it is used for What you need to know before you take VANTAVO How to take VANTAVO 
Kaj je zdravilo VANTAVO in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo VANTAVO Kako jemati zdravilo VANTAVO Možni neželeni učinki
In this study alendronate daily reduced the incidence of  1 new vertebral fracture by 47 % (alendronate 7.9 % vs. placebo 15.0 %). 
V tej študiji je dnevno zdravljenje z alendronatom zmanjšalo pojavnost enega ali več novih zlomov vretenc za 47 % (alendronat 7,9 % v primerjavi s placebom 15,0 %).
The following risk factors should be considered when evaluating an individual's risk of developing osteonecrosis of the jaw: 
Pri oceni posameznikovega tveganja za razvoj osteonekroze čeljusti je treba upoštevati naslednje dejavnike tveganja:
See your doctor immediately if you notice any of the following side effects, which may be serious, and for which you may need urgent medical treatment: 
Če opazite kateri koli izmed spodaj navedenih neželenih učinkov, ki je lahko resen, in zaradi katerega boste mogoče potrebovali nujno medicinsko oskrbo, takoj obiščite zdravnika:
It is important to maintain good oral hygiene when being treated with VANTAVO. 
Pomembno je, da med zdravljenjem z zdravilom VANTAVO vzdržujete dobro ustno higieno.
VANTAVO must be taken with water only (not mineral water) at least 30 minutes before the first food, beverage, or medicinal product (including antacids, calcium supplements and vitamins) of the day. 
Zdravilo VANTAVO je treba vzeti izključno z navadno vodo (ne z mineralno vodo) najmanj 30 minut pred prvim dnevnim obrokom hrane in pijače ali zaužitjem drugih zdravil (vključno z antacidi, pripravki kalcija in vitamini).
• allergic reactions such as hives; swelling of the face, lips, tongue and/or throat, possibly causing difficulty breathing or swallowing; severe skin reactions. 
• alergijske reakcije, kot so koprivnica, otekanje obraza, ustnic, jezika in/ali žrela, ki lahko otežuje dihanje ali požiranje, hude kožne reakcije
There were no differences in mean serum calcium, phosphate, or 24-hour urine calcium between treatment groups. 
Med skupinama ni bilo razlik v povprečni vrednosti serumskega kalcija, serumskega fosfata ali kalcija v 24-urnem urinu.
Results are insufficient to support the use of alendronate sodium in paediatric patients with osteogenesis imperfecta. 
Rezultati, ki bi podprli uporabo natrijevega alendronata pri pediatričnih bolnikih z imperfektno osteogenezo, so pomanjkljivi.
Lesser amounts are distributed to adipose and muscle tissue and stored as vitamin D3 at these sites for later release into the circulation. 
Manjše količine se porazdelijo v maščevje in mišičje, kjer se kot vitamin D3 uskladiščijo za poznejše sproščanje v obtok.
VANTAVO should not be used during pregnancy. 
Zdravila VANTAVO se med nosečnostjo ne sme uporabljati.
In the absence of adequate sunlight exposure, vitamin D3 is an essential dietary nutrient. 
V primeru nezadostne izpostavljenosti soncu, je vitamin D3 treba vnesti s hrano.
• your doctor has told you that you have Barrett's oesophagus (a condition associated with changes in the cells that line the lower oesophagus), 
• če vam je zdravnik povedal, da imate Barrettov požiralnik (stanje, povezano s spremembami sluznice v spodnjem delu požiralnika),
When you get out of bed on the day you have chosen, and before taking your first food, drink or other medicines, swallow (do not crush or chew the tablet or allow it to dissolve in your mouth) one VANTAVO tablet with a full glass of water (not mineral water). 
Ko na izbrani dan zjutraj vstanete in še preden pojeste prvo hrano ali popijete prvo pijačo ali vzamete katero koli drugo zdravilo, pogoltnite (ne zdrobite, ne žvečite in ne raztapljajte v ustih) eno tableto VANTAVO s polnim kozarcem vode (ne z mineralno vodo).
Severe vitamin D deficiency may cause muscle weakness which can lead to falls and a greater risk of fractures. 
Hudo pomanjkanje vitamina D lahko povzroči mišično oslabelost, zaradi česar se poveča verjetnost padcev in tveganje za zlome.
It is likely that calcium supplements, antacids, and some oral medicines will interfere with the absorption of VANTAVO if taken at the same time. 
Dodatki kalcija, antacidi in nekatera zdravila, ki jih zaužijete, lahko motijo absorpcijo zdravila VANTAVO, če jih vzamete istočasno.
Since Non Steroidal Anti-Inflammatory Drug (NSAID) use is associated with gastrointestinal irritation, caution should be used during concomitant use with alendronate. 
Ker so nesteroidna protivnetna zdravila (NSAR-i) povezana z draženjem prebavil, moramo biti pri sočasni uporabi z alendronatom previdni.
In clinical studies, asymptomatic, mild and transient decreases in serum calcium and phosphate were observed in approximately 18 % and 10 %, respectively, of patients taking alendronate 10 mg/day versus approximately 12 % and 3 % of those taking placebo. 
V kliničnih študijah so opazili asimptomatska, blaga in prehodna znižanja serumskega kalcija in fosfata: pri bolnikih, ki so jemali alendronat 10 mg/dan, za približno 18 % oz. 10 %, pri bolnikih, ki so jemali placebo, pa za približno 12 % oz. 3 %.
Uncommon eye inflammation (uveitis, scleritis, or episcleritis) 
Občasni vnetje oči (uveitis, skleritis ali episkleritis)
This adverse reaction was identified through post-marketing surveillance. 
Ta neželeni učinek so opažali v obdobju trženja.
Insufficiency is associated with negative calcium balance, bone loss, and increased risk of skeletal fracture. 
Pri pomanjkanju pride do negativne bilance kalcija, izgube kostnine in povečanja tveganja za zlome kosti.
6) After swallowing your VANTAVO tablet, wait at least 30 minutes before taking your first food, drink, or other medicine of the day, including antacids, calcium supplements and vitamins. 
6) Ko pogoltnete tableto VANTAVO, vsaj še 30 minut počakajte, preden zaužijete prvo hrano, pijačo ali katero koli drugo zdravilo, vključno z antacidi, dodatki kalcija in vitamini.
How to take VANTAVO tablets 
Kako jemati tablete VANTAVO
What you need to know before you take VANTAVO 
Kaj morate vedeti, preden boste vzeli zdravilo VANTAVO
Patients should be instructed that if they miss a dose of VANTAVO they should take one tablet on the morning after they remember. 
Bolnikom je treba naročiti, naj v primeru, da pozabijo vzeti odmerek zdravila VANTAVO, vzamejo eno tableto zjutraj potem, ko se spomnijo.
During bisphosphonate treatment, all patients should be encouraged to maintain good oral hygiene, receive routine dental check-ups, and report any oral symptoms such as dental mobility, pain, or swelling. 
Med zdravljenjem z bisfosfonati je treba bolnike spodbujati, da vzdržujejo dobro ustno higieno, da redno hodijo na zobozdravniške preglede in da poročajo o kakršnih koli simptomih v ustih, kot so majavost zob, bolečina ali otekanje.
Vitamin D3 is produced in the skin by conversion of 7-dehydrocholesterol to vitamin D3 by ultraviolet light. 
Vitamin D3 se tvori v koži s pretvorbo 7-dehidroholesterola v vitamin D3 z ultravijolično svetlobo.
• transient flu-like symptoms, such as aching muscles, generally feeling unwell and sometimes with fever usually at the start of treatment, 
• prehodni gripi podobni simptomi, kot npr. bolečine v mišicah, splošno slabo počutje in včasih zvišana telesna temperatura, običajno ob začetku zdravljenja
Additional supplementation with vitamin D should be considered on an individual basis taking into account any vitamin D intake from vitamins and dietary supplements. 
O jemanju dodatkov vitamina D je treba presoditi pri vsakem bolniku posebej, pri tem pa upoštevati vnos vitamina D z vitamini in prehrano.
4) Do not take VANTAVO at bedtime or before getting up for the day. 
4) Zdravila VANTAVO ne jemljite zvečer ali preden zjutraj vstanete.
In severe cases, deficiency results in secondary hyperparathyroidism, hypophosphataemia, proximal muscle weakness and osteomalacia, further increasing the risk of falls and fractures in osteoporotic individuals. 
Pri hudem pomanjkanju se pojavi sekundarni hiperparatiroidizem, hipofosfatemija, oslabelost proksimalnih mišic in osteomalacija, kar še bolj poveča tveganje za padce in zlome pri bolnikih z osteoporozo.
Circulating vitamin D3 is bound to vitamin D-binding protein. 
Vitamin D3 v obtoku je vezan na vitamin D-vezavno beljakovino.
The principal action of 1,25-dihydroxyvitamin D3 is to increase intestinal absorption of both calcium and phosphate as well as regulate serum calcium, renal calcium and phosphate excretion, bone formation and bone resorption. 
Glavni učinek 1,25-dihidroksivitamina D3 je povečanje absorpcije kalcija in fosfata v črevesju, uravnava pa tudi količino kalcija v serumu, izločanje kalcija in fosfata skozi ledvice ter tvorbo in resorpcijo kosti.
PARTICULARS TO APPEAR WITHIN THE OUTER PACKAGING (CARTON) 
PODATKI, KI MORAJO BITI NAVEDENI NA ZUNANJI OVOJNINI (ŠKATLA)
Bone and mineral metabolism Causes of osteoporosis other than oestrogen deficiency and ageing should be considered. 
Presnova kosti in mineralov Poleg pomanjkanja estrogena in staranja je treba upoštevati tudi druge vzroke za osteoporozo.
What VANTAVO looks like and contents of the pack 
Izgled zdravila VANTAVO in vsebina pakiranja
In healthy subjects, oral prednisone (20 mg three times daily for five days) did not produce a clinically meaningful change in oral bioavailability of alendronate (a mean increase ranging from 20 % to 44 %). 
Pri zdravih preiskovancih peroralni prednizon (20 mg trikrat dnevno, pet dni) ni povzročil klinično pomembne spremembe v biološki uporabnosti po peroralni uporabi alendronata (povprečni porast od 20 % do 44 %).
Non-clinical studies with the combination of alendronate and colecalciferol have not been conducted. 
Predklinične študije s kombinacijo alendronata in holekalciferola niso bile izvedene.
While no increased risk was observed in extensive clinical trials with alendronate, there have been rare (post-marketing) reports of gastric and duodenal ulcers, some of which were severe and with complications (see section 4.8). 
Čeprav v obsežnih kliničnih preskušanjih z alendronatom povečanega tveganja niso opazili, so v obdobju trženja zdravila v redkih primerih poročali o razjedah v želodcu in dvanajstniku (nekatere so bile resne in s komplikacijami) (glejte poglavje 4.8).
• a history of dental disease, poor oral hygiene, periodontal disease, invasive dental procedures and poorly fitting dentures 
• anamnezo bolezni zob, slabo ustno higieno, bolezen dlesni, invazivni zobozdravniški poseg in slabo prilegajočo zobno protezo.
Alendronate sodium is a bisphosphonate that inhibits osteoclastic bone resorption with no direct effect on bone formation. 
Natrijev alendronat je bisfosfonat, ki zavira delovanje osteoklastov in s tem kostno resorpcijo, nima pa neposrednega vpliva na proces tvorbe kosti.
Take one tablet once a week. 
Vzemite eno tableto enkrat na teden.
Patients may experience certain adverse reactions (for example, blurred vision, dizziness and severe bone muscle or joint pain (see section 4.8)) that may influence the ability to drive and use machines. 
Pri bolnikih se lahko pojavijo določeni neželeni učinki (npr. zamegljen vid, omotica in hude bolečine v kosteh, mišicah ali sklepih (glejte poglavje 4.8)), ki lahko vplivajo na sposobnost vožnje in upravljanja strojev.
Vitamin D insufficiency develops when both sunlight exposure and dietary intake are inadequate. 
Pomanjkanje vitamina D se pojavi, kadar sta premajhna tako izpostavljenost soncu, kot tudi vnos s hrano.
An Instruction Card is included in the carton for VANTAVO. 
V škatli zdravila VANTAVO je priložena kartica z navodili.
It reduces the risk of vertebral and hip fractures. 
Zmanjša tveganje za zlome hrbtenice in kolka.
At doses far higher than the human therapeutic range, reproductive toxicity has been observed in animal studies. 
Pri odmerkih, ki daleč presegajo terapevtsko območje pri ljudeh, so v študijah na živalih opazili škodljiv vpliv na sposobnost razmnoževanja.
• potency of the bisphosphonate (highest for zoledronic acid), route of administration (see above) 
• jakost bisfosfonatov (največja pri zoledronski kislini), pot uporabe (glejte zgoraj) in kumulativni odmerek,
• stomach or peptic ulcers (sometimes severe or with bleeding), 
• razjede v želodcu ali dvanajstniku (včasih hude ali s krvavitvijo)
Osteonecrosis of the jaw has also been reported in patients with osteoporosis receiving oral bisphosphonates. 
O osteonekrozi čeljusti so poročali tudi pri bolnikih z osteoporozo, ki so prejemali peroralne bisfosfonate.
- Abnormalities of the oesophagus and other factors which delay oesophageal emptying such as stricture or achalasia. 
- Nenormalnosti požiralnika in drugi dejavniki, ki upočasnjujejo praznjenje požiralnika, kot sta zožitev ali ahalazija.