natgillin/translations-raw huggingface dataset:
How is Rituzena used? 
Kako se zdravilo Rituzena uporablja?
In GPA and MPA, destroying the B cells lowers the production of antibodies thought to play an important role in attacking the blood vessels and causing 
Pri Wegenerjevi granulomatozi in mikroskopskem poliangiitisu se z uničenjem celic B zniža tvorba protiteles, ki naj bi imela pomembno vlogo pri napadanju krvnih žil in povzročanju vnetja.
The company that markets Rituzena will provide doctors and patients using the medicine for noncancer conditions with educational material including information on the need to give the medicine where facilities for resuscitation are available and on the risk of infection, including PML. 
Družba, ki trži zdravilo Rituzena, bo za zdravnike in bolnike, ki uporabljajo zdravilo za nerakave bolezni, pripravila izobraževalno gradivo, v katerem bo opisano, da je zdravilo treba dajati v ustanovah, kjer je na voljo oprema za oživljanje, in da obstaja tveganje okužbe, vključno s progresivno multifokalno levkoencefalopatijo (PML).
Rituzena is a ‘biosimilar medicine'. 
Zdravilo Rituzena je „podobno biološko zdravilo“.
When rituximab attaches to CD20, it causes the death of B cells, which helps in lymphoma and CLL, where B cells have become cancerous. 
Rituksimab z vezavo na CD20 povzroči odmrtje celic B, kar pripomore k zdravljenju limfoma in kronične limfocitne levkemije, pri kateri so celice B postale rakaste.
For the full list of side effects reported with Rituzena, see the package leaflet. 
Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Rituzena, glejte navodilo za uporabo.
For practical information about using Rituzena, patients should read the package leaflet or contact their 
Za praktične informacije o uporabi zdravila Rituzena naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
Laboratory studies comparing Rituzena with MabThera have shown that the active substance in Rituzena is highly similar to that in MabThera in terms of structure, purity and biological activity. 
Laboratorijske študije, v katerih so zdravilo Rituzena primerjali z zdravilom MabThera, so pokazale, da je zdravilna učinkovina zdravila Rituzena po zgradbi, čistosti in biološkem delovanju zelo podobna zdravilni učinkovini v zdravilu MabThera.
In addition, Rituzena has been compared with MabThera given into a vein in a main study involving 372 patients with active rheumatoid arthritis (an inflammatory disease). 
Poleg tega so zdravilo Rituzena v glavni študiji, v katero je bilo vključenih 372 bolnikov z aktivnim revmatoidnim artritisom (vnetno boleznijo), primerjali z zdravilom MabThera, injiciranim v veno.
Rituzena is a medicine used in adults to treat the following blood cancers and inflammatory conditions: • follicular lymphoma and diffuse large B cell non-Hodgkin's lymphoma (two types of non-Hodgkin's 
• folikularnega limfoma in difuznega velikoceličnega B ne-Hodgkinovega limfoma (dveh vrst neHodgkinovega limfoma, tj. krvnega raka);
Studies have also shown that giving Rituzena produces similar levels of the active substance in the 
Študije so pokazale tudi, da zdravilo Rituzena vzpostavi podobne ravni zdravilne učinkovine v telesu kot zdravilo MabThera.
Rituzena can only be obtained with a prescription. 
Predpisovanje in izdaja zdravila je le na recept.
Further treatment should be symptomatic. 
Nadaljnje zdravljenje naj bo simptomatsko.
If this applies to you, use appropriate contraception to avoid the possibility of an unplanned pregnancy. 
Če to velja za vas, uporabljajte ustrezno kontracepcijo, da preprečite možnost nenačrtovane nosečnosti.
- if you retain water (fluid retention) or have heart failure problems in particular if you are over 75 years old. 
- če zadržujete vodo (zastajanje tekočine) ali imate težave s srčnim popuščanjem, zlasti če ste starejši od 75 let.
Overall no additional risk of accumulation is to be assumed in such patients. 
Na splošno pri takih bolnikih ni treba predvideti dodatnega tveganja akumulacije.
Distribution The estimated volume of distribution in humans is 0.25 L/kg. 
Porazdelitev Ocenjeni volumen porazdelitve pri človeku je 0,25 l/kg.
Talk to your doctor before stopping this treatment. 
Posvetujte se s svojim zdravnikom, preden prekinete to zdravljenje.
Artificial sweeteners have no effect. 
Umetna sladila nimajo takšnega učinka.
Your doctor will check whether Tandemact is working 3 to 6 months after you start taking it. 
Zdravnik bo preveril ali zdravilo Tandemact deluje, 3 do 6 mesecev po tem, ko začnete jemati zdravilo.
In healthy persons, the minimum effective oral dose is approximately 0.6 mg. 
Pri zdravih osebah je najmanjši učinkoviti peroralni odmerek približno 0,6 mg.
- if you are already taking other medicines for the treatment of diabetes. 
- če že jemljete druga zdravila za zdravljenje sladkorne bolezni.
However, this did not lead to an increase in mortality in this study. 
Vendar pa v tej študiji to ni povzročilo povečane smrtnosti.
This check should be repeated at intervals. 
Ta pregled je treba ponavljati v rednih časovnih presledkih.
There was no relevant accumulation. 
Ni bilo nobenega pomembnega kopičenja.
These problems generally get better after you stop taking Tandemact. 
Te težave se običajno izboljšajo, ko prenehate jemati zdravilo Tandemact.
Your doctor will tell you the dose to take or if necessary to change to a different dose. 
Zdravnik vam bo povedal kakšen odmerek vzemite ali, če je potrebno, da odmerek spremenite.
The maximum reported dose of 120 mg/day for four days, then 180 mg/day for seven days was not associated with any symptoms. 
Najvišji poročani odmerek 120 mg/dan štiri dni, zatem pa 180 mg/dan sedem dni, ni bil povezan s kakimi simptomi.
Children and adolescents Use in children and adolescents under 18 years is not recommended. 
Otroci in mladostniki Uporabe pri otrocih in mladostnikih, mlajših od 18 let ne priporočamo.
- if you have a problem with your liver. 
- če imate težave s srcem.
Via Crosa 86, 28065 Cerano (NO) Italy 
Via Crosa 86, 28065 Cerano (NO) Italija
Do not throw away any medicines via waste water or household waste. 
Zdravila ne smete odvreči v odpadno vode ali med gospodinjske odpadke.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 08 January 2007 
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve: 08. januar 2007 Datum zadnjega podaljšanja: 09. september 2016
Tandemact is contraindicated in patients with: 
Zdravilo Tandemact je kontraindicirano pri:
In particular, patients have experienced the following serious side effects: 
V glavnem so se pri bolnikih pojavili naslednji resni neželeni učinki:
Tandemact should be used every day to work properly. 
Zdravilo Tandemact je treba jemati vsak dan, da bi delovalo pravilno.
These can also hide the signs of hypoglycaemia, so special care is needed when taking these medicines 
Ta zdravila lahko tudi prikrijejo znake hipoglikemije, zato je potrebna posebna pozornost pri jemanju teh zdravil.
Do not use Tandemact if you are pregnant. 
Ne jemljite zdravila Tandemact, če ste noseči.
The tablets should be swallowed with a glass of water. 
Tablete je treba pogoltniti s kozarcem vode.
In case of (severe) overdose hospitalisation in an intensive care department is indicated. 
V primeru (resnega) prevelikega odmerka je indicirana hospitalizacija v oddelku za intenzivno nego.
Symptoms can almost always be promptly controlled by immediate intake of carbohydrates (sugar). 
Simptomi so lahko skoraj vedno takoj pod nadzorom s takojšnjim zaužitjem ogljikovih hidratov (sladkorja).
It is important to know what symptoms to expect when hypoglycaemia (low blood sugar) occurs. 
Pomembno je vedeti, katere simptome lahko pričakujete, ko se pojavi hipoglikemija (nizka raven sladkorja v krvi).
The recommended dose of Tandemact is one tablet taken once daily. 
Priporočeni odmerek zdravila Tandemact je ena tableta vzeta enkrat dnevno.
In clinical studies, patients have taken pioglitazone at higher than the recommended highest dose of 45 mg daily. 
V kliničnih študijah so bolniki jemali pioglitazon v višjem od najvišjega priporočenega odmerka 45 mg na dan.
The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal. 
• Redno posodobljena poročila o varnosti zdravila (PSUR) Zahteve glede predložitve rednega posodobljenega poročila o varnosti zdravila so določene v seznamu referenčnih datumov EU (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES, in vseh kasnejših posodobitvah, objavljenih na evropskem spletnem portalu o zdravilih.
2 In very rare cases mild hypersensitivity reactions may develop into serious reactions with dyspnoea, fall in blood pressure and sometimes shock. 
2 V zelo redkih primerih se lahko blage preobčutljivostne reakcije razvijejo v resne reakcije z dispnejo, padcem krvnega tlaka in včasih šokom.
What Tandemact is and what it is used for 
Kaj je zdravilo Tandemact in za kaj ga uporabljamo
You must tell your doctor if you are, you think you may be pregnant or are planning to have a baby. 
Svojemu zdravniku povejte, če menite, da ste noseči ali načrtujete zanositev.
Your blood sugar could fall below the normal level. 
Krvni sladkor lahko pade pod normalno raven.
Pharmacokinetics in five non-diabetic patients after bile duct surgery were similar to those in healthy persons. 
Farmakokinetika pri petih nediabetičnih bolnikih po operaciji žolčevoda je bila podobna tisti pri zdravih ljudeh.
The tablets are taken orally shortly before or with the first main meal. 
Tablete se jemljejo peroralno neposredno pred ali s prvim glavnim obrokom.
Based on the experience with glimepiride and with other sulphonylureas the following interactions have to be mentioned. 
Na podlagi izkušenj z glimepiridom in drugimi sulfonilsečninami, je treba omeniti naslednja medsebojna delovanja.
It is known from other sulphonylureas that, despite initially successful countermeasures, hypoglycaemia may recur. 
Iz uporabe drugih sulfonilsečnin je znano, da se lahko kljub prvotno uspešnim protiukrepom, hipoglikemija ponovno pojavi.
Patients who experience visual disturbance should be cautious when driving or using machines. 
Bolniki, ki imajo izkušnjo z motnjo vida bi morali biti previdni pri vožnji ali upravljanju s stroji.
very rare very rare hypersensitivity and allergic reactions3 
zelo redki zelo redki preobčutljivost in alergijske reakcije3
For this reason, other medicinal products should only be taken with Tandemact with the knowledge (or at the prescription) of the doctor. 
Zato se lahko druga zdravila jemljejo skupaj z zdravilom Tandemact zgolj ob vednosti (ali po navodilu) zdravnika.
Glimepiride has a very low distribution volume (approximately 8.8 litres) which is roughly equal to the albumin distribution space, high protein binding (> 99%), and a low clearance (approximately 48 mL/min). 
Glimepirid ima zelo nizek volumen porazdelitve (približno 8,8 litrov), kar je približno enako površini porazdelitve albumina, visoko vezavo na beljakovine (99%) in nizek očistek (približno 48 ml/min).
Ask your doctor or pharmacist for more information if you are not sure how to recognise this and what you should do if you experience the symptoms. 
Vprašajte svojega zdravnika ali farmacevta za dodatne informacije, če niste prepričani, kako prepoznati to stanje in kaj morate storiti, če se pojavijo simptomi.
In diabetic patients, good metabolic control over 24 hours can be achieved with a single daily dose. 
Pri diabetikih je mogoče dobro 24-urno presnovno urejenost doseči z enim samim odmerkom na dan.
Pharmacokinetics were similar in males and females, as well as in young and elderly (above 65 years) patients. 
Farmakokinetike so bile podobne pri moških in ženskah ter pri mlajših in starejših (nad 65 let) bolnikih.
Although in very rare cases fatal outcome has been reported, causal relationship has not been established. 
Čeprav so poročali o zelo redkih primerih s smrtnim izidom, vzročna povezanost ni bila ugotovljena.
What you need to know before you take Tandemact 
Kaj morate vedeti, preden boste vzeli zdravilo Tandemact
Comparison of single and multiple once-daily dosing revealed no significant differences in pharmacokinetics, and the intra-individual variability was very low. 
Primerjava med jemanjem odmerkov enkrat in večkrat na dan ni pokazala nobenih pomembnih razlik v farmakokinetiki, intraindividualna variabilnost pa je bila zelo nizka.
- if you have problems with your enzyme called Glucose-6-phosphodehydrogenase since it can decrease your red cells. 
- če imate težave z encimom, imenovanim glukoza-6-fosfodehidrogenaza, ker lahko le-ta zmanjša število rdečih krvnih telesc.
This study showed an increase in reports of heart failure; however this did not lead to an increase in mortality in this study. 
Študija je pokazala povečano število poročil o srčnem popuščanju; vendar pa v tej študiji to ni povzročilo povečane smrtnosti.
Although the hydroxy metabolite of glimepiride caused a small but significant decrease in serum glucose in healthy persons, it accounts for only a minor part of the total effect. 
Čeprav je hidroksi-presnovek glimepirida povzročil majhno, a pomembno znižanje glukoze v serumu zdravih ljudi, to predstavlja le manjši del celotnega učinka zdravila.
There have been no formal interaction studies for Tandemact, however, the concomitant use of the active substances in patients in clinical use has not resulted in any unexpected interactions. 
Formalne raziskave o interakcijah za zdravilo Tandemact niso bile narejene, vendar sočasno jemanje učinkovin pri bolnikih pri klinični uporabi ni povzročilo nobenih nepričakovanih interakcij.
Take Tandemact daily as prescribed. 
Jemljite zdravilo Tandemact vsak dan, kakor vam je predpisano.
There may be an increased possibility of becoming pregnant because you may ovulate again when you take Tandemact. 
Obstaja lahko povečana možnost zanositve, saj lahko pride do ponovne ovulacije, ko vzamete zdravilo Tandemact.
6 Elevation of liver enzymes may occur. 
6 Jetrni encimi se lahko zvišajo.
The safety and efficacy of Tandemact in children and adolescents under 18 years of age have not been established. 
Varnost in učinkovitost zdravila Tandemact pri otrocih in mladostnikih, mlajših od 18 let, še nista bili dokazani.
These findings were observed across species at plasma concentrations  4 times the clinical exposure. 
Te ugotovitve so potrdila opažanja pri vseh vrstah pri plazemskih koncentracijah  4-kratne plazemske koncentracije pri klinični izpostavitvi.
After ingestion of an overdose of glimepiride, hypoglycaemia may occur, lasting from 12 to 72 hours, and may recur after initial recovery. 
Po zaužitju prevelikega odmerka glimepirida se lahko pojavi hipoglikemija, ki traja od 12 do 72 ur in se lahko po navideznem okrevanju ponovi.
very rare very rare 
zelo redki zelo redki
After high doses, slightly longer half-lives were noted. 
Po višjih odmerkih so bili opaženi malce daljši razpolovni časi.
Other medicines and Tandemact 
Druga zdravila in zdravilo Tandemact
- if you have a special type of diabetic eye disease called macular oedema (swelling of the back of the eye), talk to your doctor if you notice any change to your vision. 
- če imate posebno obliko diabetične očesne bolezni imenovano makularni edem (otekanje zadnjega dela očesa), če opazite kakršnokoli spremembo vida, se posvetujte z zdravnikom.
Your blood sugar level can be increased by taking sugar. 
Raven sladkorja v krvi se lahko poveča tako, da vzamete sladkor.
very rare very rare allergic vasculitis2 
zelo redki zelo redki alergijski vaskulitis2
In the latter (covering embryotoxicity, teratogenicity and developmental toxicity), undesirable effects observed were considered to be secondary to the hypoglycaemic effects induced by the compound in dams and in offspring. 
Pri slednjem (ki zajema embriotoksičnost, teratogenost in razvojno toksičnost) so bili opaženi neželeni učinki sekundarni hipoglikemičnim učinkom, ki jih je sestavina povzročila pri samicah in potomcih.
Your doctor may take blood tests to monitor your blood cell levels and liver function. 
Zdravnik se lahko odloči za krvne preiskave, da preveri raven krvnih celic in delovanje jeter.
Immune system disorders allergic shock2 
Bolezni imunskega sistema alergijski šok2
Severe hypoglycaemia or prolonged hypoglycaemia, only temporarily controlled by the usual amounts of sugar, require immediate medical treatment and occasionally hospitalisation. 
V primeru hude ali podaljšane hipoglikemije, ki jo je moč le začasno nadzirati z običajnimi količinami sladkorja, je potrebno takojšnje zdravljenje in včasih hospitalizacija.
Rare (may affect up to 1 in 1,000 people) - noticeable changes in blood 
Redki (pojavijo se lahko pri največ 1 od 1.000 bolnikov) - opazne spremembe v krvi
Two metabolites - most probably resulting from hepatic metabolism (major enzyme is CYP2C9) - were identified both in urine and faeces: the hydroxy derivative and the carboxy derivative. 
Dva metabolita - verjetno zaradi jetrne presnove (glavni encim je CYP2C9) - sta bila najdena tako v urinu kot tudi v blatu: hidroksi-derivat in karboksi-derivat.
Cross allergenicity with sulphonylureas, sulphonamides or related substances is possible. 
Možna je navzkrižna alergenost s sulfonilsečninami, sulfonamidi ali sorodnimi snovmi.
Tell your doctor or pharmacist if you are taking any of these. 
Obvestite zdravnika ali farmacevta, če jemljete katero od teh zdravil.
If you have a serious allergic reaction, including hives and swelling of the face, lips, tongue, or throat that may cause difficulty in breathing or swallowing stop taking this medicine and talk to your doctor immediately. 
Če imate resno alergijsko reakcijo, ki vključuje koprivnico in otekanje obraza, ustnic, jezika ali grla, ki lahko povzroča težave z dihanjem ali požiranjem, takoj prenehajte z jemanjem tega zdravila in se nemudoma pogovorite s svojim zdravnikom.
This is particularly important in those who have reduced or absent awareness of the warnings of hypoglycaemia or have frequent episodes of hypoglycaemia. 
To je posebej pomembno pri bolnikih z zmanjšanim ali odsotnim zaznavanjem opozorilnih znakov hipoglikemije in pri tistih, ki imajo pogoste hipoglikemije.
In particular when treating hypoglycaemia due to accidental intake of Tandemact in infants and young children, the dose of glucose given must be carefully controlled to avoid the possibility of producing dangerous hyperglycaemia. 
Zlasti pri zdravljenju hipoglikemije zaradi akcidentalnega zaužitja zdravila Tandemact pri dojenčkih in majhnih otrocih, je treba odmerek glukoze skrbno nadzirati, da bi se izognili možnosti za pojav nevarne hiperglikemije.
Tandemact helps control the level of sugar in your blood when you have type 2 diabetes by increasing the amount of insulin available and helping your body make better use of it. 
Zdravilo Tandemact pomaga nadzorovati raven sladkorja v krvi, če imate sladkorno bolezen tipa 2, in sicer tako, da povečuje količino insulina, ki je na voljo in telesu pomaga bolje izkoristiti insulin.
As with other sulphonylureas this effect is based on an increase of responsiveness of the pancreatic beta cells to the physiological glucose stimulus. 
Tako kot pri drugih sulfonilsečninah ta učinek temelji na izboljšani odzivnosti pankreatičnih celic beta na fiziološki glukozni stimulus.
In light of age-related risks (especially bladder cancer, fractures and heart failure), the balance of benefits and risks should be considered carefully both before and during treatment in the elderly. 
Glede na s starostjo povezana tveganja (zlasti rak mehurja, zlomi in srčno popuščanje), je treba pri starejših ravnovesje med koristmi in tveganji skrbno pretehtati pred in med zdravljenjem.
The following statements reflect the pharmacokinetic properties of the individual active substances of Tandemact. 
Naslednje ugotovitve odražajo farmakokinetične lastnosti individualnih učinkovin v zdravilu Tandemact.
This type 2 diabetes usually develops in adulthood where the body either does not produce enough insulin (a hormone that controls blood sugar levels), or cannot effectively use the insulin it produces. 
Sladkorna bolezen tipa 2 se običajno razvije v odrasli dobi, ko telo ali ne proizvaja dovolj insulina (hormon, ki nadzira raven sladkorja v krvi) ali pa ne more učinkovito uporabiti proizvedenega insulina.
However if you miss a dose, skip the missed dose and just carry on with the next dose as normal. 
Če pa pozabite vzeti odmerek, preskočite pozabljeni odmerek in nadaljujte z naslednjim odmerkom kot sicer.
This is a serious reaction which may occur uncommonly (≥ 1/1,000 to < 1/100) (see section 4.4). 
To je resna reakcija, ki se lahko pojavi občasno (≥ 1/1.000 do < 1/100) (glejte poglavje 4.4).
Takeda Ireland Limited, Bray Business Park, Kilruddery, County Wicklow, Ireland Delpharm Novara S.r.l., Via Crosa, 86, 28065 Cerano (NO), Italy Takeda GmbH, Production Site Oranienburg, Lehnitzstrasse 70 - 98, 16515 Oranienburg, Germany 
Takeda Ireland Limited, Bray Business Park, Kilruddery, County Wicklow, Irska Delpharm Novara S.r.l., Via Crosa, 86, 28065 Cerano (NO), Italija Takeda GmbH, Production Site, Oranienburg, Lehnitzstrasse 70 - 98, 16515 Oranienburg, Nemčija
Epidemiological studies have also suggested a small increased risk of bladder cancer in diabetic patients treated with pioglitazone, although not all studies identified a statistically significant increased risk. 
Tudi epidemiološke študije, kažejo malo večje tveganje za rak mehurja pri bolnikih s sladkorno boleznijo zdravljenih s pioglitazonom, čeprav pri vseh študijah povečanje tveganja ni bilo statistično signifikantno
Patients should be observed for signs and symptoms of heart failure, weight gain or oedema; particularly those with reduced cardiac reserve. 
Bolnike je treba opazovati glede znakov in simptomov srčnega popuščanja, povišanja telesne mase ali edemov; posebno tiste z zmanjšano srčno rezervo.
Risk related to glimepiride 
Tveganje, povezano z glimepiridom
There are no adequate data from the use of glimepiride in pregnant women. 
Ni zadostnih podatkov o uporabi glimepirida pri nosečnicah.
5 Gastro-intestinal complaints are very rare and seldom lead to discontinuation of therapy. 
5 Bolezni prebavil so zelo redke in redko povzročijo prekinitev zdravljenja.
No increase in mortality from heart failure was observed. 
Dviga smrtnosti zaradi srčnega popuščanja niso opazili.
When you take Tandemact, your blood sugar could fall below the normal level (hypoglycaemia). 
Ko boste vzeli zdravilo Tandemact, lahko krvni sladkor pade pod normalno raven (hipoglikemija).
In very rare cases, impairment of liver function (e.g. with cholestasis and jaundice) may develop, as well as hepatitis which may progress to liver failure. 
V zelo redkih primerih se lahko razvije okvara delovanja jeter (npr. s holestazo in zlatenico) ter hepatitis, ki lahko napreduje v odpoved jeter.
Do not use Tandemact if you are breastfeeding or are planning to breast-feed (see section “Do not take Tandemact”). 
Ne jemljite zdravila Tandemact če dojite ali nameravate dojiti (glejte poglavje “Ne jemljite zdravila Tandemact”).
Takeda GmbH Production Site Oranienburg Lehnitzstrasse 70 - 98 16515 Oranienburg, Germany 
Takeda GmbH Production Site Oranienburg Lehnitzstrasse 70 - 98, 16515 Oranienburg, Nemčija
14 tablets 28 tablets 30 tablets 50 tablets 90 tablets 98 tablets 
14 tablet 28 tablet 30 tablet 50 tablet 90 tablet 98 tablet
The recommended dose is one tablet taken once daily shortly before or with the first main meal. 
Priporočeni odmerek je ena tableta dnevno neposredno pred ali s prvim glavnim obrokom.
Food intake has no relevant influence on absorption, only absorption rate is slightly diminished. 
Vnos hrane nima pomembnega vpliva na absorpcijo, deloma se zniža hitrost absorpcije.
In animals, glimepiride is excreted in milk. 
Pri živalih se glimepirid izloča v mleku.
8 Oedema was reported in 6-9% of patients treated with pioglitazone over one year in controlled clinical trials. 
8 O edemih so poročali pri 6-9% bolnikov, zdravljenih s pioglitazonom leto dni v kontroliranih kliničnih preskušanjih.