natgillin/translations-raw huggingface dataset:
Data were inconclusive with regards to the indication for O. rhinotracheale, but it was concluded that on the basis of well established use and as there have been no reports of adverse events, including suspected lack of expected efficacy, the current dosage could be considered to be safe and effective. 
Podatki glede indikacije za O. rhinotracheale niso omogočali dokončnih zaključkov, vendar je bilo sklenjeno, da se lahko na podlagi dobro uveljavljene uporabe, in ker ni nobenih poročil o neželenih učinkih, vključno z domnevno manjšo učinkovitostjo od pričakovane, sedanji odmerki štejejo za varne in učinkovite.
Formed from a polyester/polyethylene/aluminium/polyethylene or a polyester/ polyethylene/aluminium/ionomer laminate. 
Vrečka iz poliestra/polietilena/aluminija/polietilena ali iz poliester/ polietilen/aluminij/ionomer laminata.
In case of severe infections the medication period may be prolonged for a maximum of 8 consecutive days as determined by the attending veterinary surgeon. 
Pri hudih okužbah se lahko obdobje zdravljenja podaljša na največ 8 zaporednih dni, kot to odloči lečeči veterinar.
During preparation and administration of the medicated drinking water, skin contact with the product and inhalation of dust particles should be avoided. 
Med pripravljanjem in dajanjem pitne vode z zdravilom se je treba izogibati stiku kože z zdravilom in vdihavanju prašnih delcev.
Especially cell-division and the formation of the cell wall are impaired. 
Posebno oslabljeni sta pri tem celična delitev in nastajanje celične stene.
It is recommended to prepare a concentrated pre-solution - approximately 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required. 
Priporočljivo je pripraviti koncentrirano predraztopino - približno 100 gramov zdravila na liter pitne vode -, ki se jo po potrebi redči na terapevtske koncentracije.
Tetracycline resistance is usually acquired by means of plasmids or other mobile elements (e.g. conjugative transposones). 
Odpornost na tetraciklin se običajno pridobi s pomočjo plazmidov ali drugih mobilnih elementov (npr. konjugativnih transpozonov).
However, it is accepted that levels of resistance to tetracyclines reported in literature cannot be directly extrapolated to doxycycline, and that the greater liposolubility of doxycycline may explain why in vitro susceptibility of organisms has been maintained despite the emerging resistance to tetracycline. 
Vendar pa velja, da ravni odpornosti na tetracikline, o katerih so poročali v literaturi, ni mogoče neposredno ekstrapolirati na doksiciklin ter da lahko večja topnost doksiciklina v maščobi pojasni, zakaj se je občutljivost organizmov in vitro ohranila kljub pojavljajoči se odpornosti na tetraciklin.
In order to obtain the correct dosage the concentration of doxycycline has to be adjusted accordingly. 
Za pravilen odmerek je treba prilagajati koncentracijo doksiciklina.
There have been no data to indicate increasing levels of resistance and the relevance of cross resistance between doxycycline and older tetracyclines was also discussed but again data were insufficient to enable firm conclusions to be reached. 
Nobeni podatki niso kazali na povečane ravni odpornosti, razpravljali pa so tudi o pomenu navzkrižne odpornosti med doksiciklinom in starejšimi tetraciklini, vendar tudi tukaj podatki niso zadostovali za sklepanje zanesljivih zaključkov.
Published data related to existing levels of resistance to doxycycline in target pathogens was also submitted. 
Predloženi so bili tudi objavljeni podatki v zvezi z obstoječimi ravnmi odpornosti na doksiciklin pri ciljnih patogenih.
PROHIBITION OF SALE, SUPPLY AND/OR USE To be completed nationally 
PREPOVED PRODAJE, OSKRBE IN/ALI UPORABE Izpolni država članica
From these data it may be predicted that doxycycline concentrations would exceed the MIC in the target tissue for the majority of the named pathogens in pigs. 
Na podlagi teh podatkov je mogoče sklepati, da bi koncentracije doksiciklina presegle vrednost MIC v ciljnem tkivu za večino imenovanih patogenov pri prašičih.
In the event of eye or skin contact, rinse the affected area with large amounts of clean water and if irritation occurs, seek medical attention. 
Ob stiku z očmi ali kožo mesto sperite z veliko količino čiste vode in, če pride do razdraženosti, poiščite zdravniško pomoč.
The Marketing Authorisation Holder provided persuasive argument that in the field differentiation between Pasteurellosis and O. rhinotracheale in poultry could be readily achieved. 
Imetnik dovoljenja za promet z zdravilom je predstavil prepričljiv argument, da bi bilo mogoče na terenu pri piščancih hitro doseči diferenciacijo med Pasteurellosis in O. rhinotracheale.
As eradication of the target pathogens may not be achieved, medication should therefore be combined with good management practices, e.g. good hygiene, proper ventilation, no overstocking. 
Ker izkoreninjenja ciljnih patogenov ni vedno mogoče doseči, je treba zdravljenje zato združiti z dobro prakso upravljanja, npr. z dobro higieno, pravilnim prezračevanjem in preprečevanjem prenapolnjenosti vzrejnega objekta.
There are no changes to the dosing regimen being proposed for either chickens or pigs therefore there will be no increased exposure of the environment to doxycycline. 
Ker niti pri piščancih niti pri prašičih niso predlagane nobene spremembe pri režimu odmerjanja, tudi okolje doksiciklinu ne bo izpostavljeno v večji meri.
These antibiotics have a broad spectrum of antimicrobial activity, sharing the same basic structure of polycyclic naphthacenecarboxamide. 
Ti antibiotiki imajo širok spekter protimikrobnega delovanja, z isto osnovno strukturo, kot jo imajo policiklični naftacenkarboksamidi.
DATE OF REVISION OF THE TEXT To be completed nationally 
DATUM REVIZIJE BESEDILA Izpolni država članica
If suspected adverse reactions occur, treatment should be discontinued. 
Ob sumu na neželene reakcije je treba zdravljenje prekiniti.
Avoid direct contact with skin and eyes when handling the product to prevent sensitisation and contact dermatitis. 
Pri delu z izdelkom se izogibajte neposrednemu stiku s kožo in očmi, da ne pride do preobčutljivosti in kontaktnega dermatitisa.
Doxycycline increases the action of anticoagulants. 
Doksiciklin povečuje delovanje antikoagulantov.
These warnings have been broadened to take account of resistance to tetracyclines recognised in isolates from pigs. 
Ta opozorila so nekoliko razširili, tako da vključujejo tudi odpornost na tetracikline, ki so jo odkrili v izolatih iz prašičev.
Keep the bag tightly closed after first opening in order to protect from moisture. 
Po prvem odprtju vrečko hranite tesno zaprto, da zagotovite zaščito pred vlago.
LABELLING 10 x 100 g 
OZNAČEVANJE 10 x 100 g
Do not use within 4 weeks of onset of the laying period. 
Ne uporabljati 4 tedne pred začetkom obdobja nesnosti.
MANUFACTURER'S BATCH NUMBER Lot{number} 
IZDELOVALČEVA ŠTEVILKA SERIJE Lot {številka}
Doxycycline has a low affinity for forming complexes with calcium and studies have demonstrated that doxycycline scarcely affects skeleton formation. 
Doksiciklin ima nizko afiniteto za tvorjenje kompleksov s kalcijem in študije so pokazale, da doksiciklin redko vpliva na oblikovanje okostja.
- Eggs: Not authorised for use in laying birds producing eggs for human consumption. 
- Jajca: Ni dovoljeno za uporabo pri pticah nesnicah jajc za prehrano ljudi.
Due to the greater liposolubility and greater facility to pass through cell membranes (in comparison to tetracycline), doxycycline retains a certain degree of efficacy against microorganisms with acquired resistance to tetracyclines. 
Zaradi večje topnosti v lipidih in večje zmožnosti za prehod skozi celične membrane (v primerjavi s tetraciklini), doksiciklin proti mikroorganizmom, ki so pridobili odpornost proti tetraciklinom, ohranja določeno stopnjo učinkovitosti.
List of the names, pharmaceutical form(s), strength of the veterinary medicinal products, animal species, route of administration, applicant/marketing authorisation holder in the member states 
Seznam imen, farmacevtskih oblik, jakosti zdravila za uporabo v veterinarski medicini, živalskih vrst, poti uporabe in imetnikov dovoljenja za promet z zdravilom v državah članicah
Doxycycline is listed as a “highly important antimicrobial” for human use, and “critically important” for veterinary use according to the WHO criteria, 2007. 
Doksiciklin je po merilih SZO iz leta 2007 naveden kot „zelo pomembno protimikrobno sredstvo“ za uporabo pri ljudeh in „kritično pomemben“ za veterinarsko uporabo.
Risk Assessment 
Ocena tveganja
In addition, in the absence of any adverse pharmacovigilance data indicating suspected lack of expected efficacy, it is considered that revision of the dose rate and regimen is not justified. 
Poleg tega se v odsotnosti kakršnih koli farmakovigilančnih podatkov o neželenih učinkih, ki bi kazali na domnevno manjšo učinkovitost od pričakovane, pregled odmerka in režima odmerjanja šteje kot neutemeljen.
At the time of the Article 35 referral, there was no documented evidence in relation to suspected lack of expected efficacy of doxycycline products in chickens. 
V času napotitve v skladu s členom 35 niso bili dokumentirani nobeni dokazi glede domnevno manjše učinkovitosti zdravil z doksiciklinom od pričakovane pri piščancih.
Food-borne, direct as well as environmental transmission of resistant microorganisms (resistant determinants) has to be considered a risk related to the use of the product despite the fact that quantification of transmission of zoonotic agents and horizontal transfer of resistance genes between animal and human bacteria is extremely difficult in vivo (F. J. Angulo et al., 2004)4. 
Prenos s hrano ter neposredni in okoljski prenos odpornih mikroorganizmov (odporne determinante) je treba upoštevati kot tveganje, povezano z uporabo zdravila, ne glede na dejstvo, da je kvantifikacija in vivo prenosa povzročiteljev zoonoze ter horizontalnega prenosa genov odpornosti med živalskimi in človeškimi bakterijami zelo težavna (F. J. Angulo et al., 2004)4.
Pharmacotherapeutic group: Antibacterial - Tetracycline. 
Farmakoterapevtska skupina: Protibakterijsko zdravilo - tetraciklin.
If you develop symptoms following exposure such as skin rash, you should seek medical advice and show this warning to the physician. 
Če se po izpostavljenosti pojavijo simptomi, kot so izpuščaji na koži, morate poiskati zdravniško pomoč in toopozorilo pokazati zdravniku.
Pigs: - Meat and offal: 4 days 
Prašiči: - meso in organi: 4 dni
Wear impermeable gloves (e.g. rubber or latex) and an appropriate dust mask (e.g. disposable half-mask respirator conforming to European Standard EN149) when applying the product. 
Nosite pri uporabi zdravila nepremočljive rokavice (npr. iz gume ali lateksa) in ustrezno masko (npr. respirator za enkratno uporabo s pol-obrazno masko v skladu z evropskim standardom EN149).
Precipitation will occur in an alkaline solution. 
V alkalnih raztopinah pride do precipitacije.
From 24 h up to 96 h after start of treatment the doxycycline plasma concentrations exceeded 2 µg/ml. 
Od 24 h do 96 ur po začetku zdravljenja so koncentracije doksiciklina presegale 2 µg/ml.
Shelf-life after first opening the packaging: 9 months. 
Rok uporabnosti po prvem odpiranju ovojnine: 9 mescev.
In addition, no evidence from pharmacovigilance of serious risk has been demonstrated to be associated with the current dosing regimens for chickens or pigs and as such they can be maintained. 
Prav tako ni nobenih farmakovigilančnih dokazov, ki bi kazali na resno tveganje, povezano s trenutnim režimom odmerjanja za piščance ali prašiče, kar pomeni, da se tak režim odmerjanja lahko ohrani.
In the absence of specific studies the use of the product is not recommended during pregnancy or lactation. 
Ker ni na razpolago ustreznih študij, se uporaba zdravila med nosečnostjo ali dojenjem ne priporoča.
The following formula can be used to calculate the concentration of the product in drinking water: 
Za izračun koncentracije zdravila v pitni vodi se lahko uporabi naslednjo formulo:
Bousquet et al. 19973 provides evidence of minimum inhibitory concentrations (MICs) of doxycycline against: P. multocida of 0.13 - 2.0 µg/ml (55 strains), A. pleuropneumoniae 0.25 - 2.0 µg/ml (59 strains), M. hyponeumoniae 0.016 - 2 µg/ml (26 strains). 
Avtor Bousquet et al. 19973 predstavlja dokaze o minimalnih inhibitornih koncentracijah (MIC) doksiciklina proti: P. multocida 0,13-2,0 µg/ml (55 sevov), A. pleuropneumoniae 0,25-2,0 µg/ml (59 sevov), M. hyopneumoniae 0,016-2 µg/ml (26 sevov).
6.4 Storage precautions 
6.4 Previdnostni ukrepi pri shranjevanju
The majority of the data quoted related to tetracycline resistance generally, and it was noted that resistance to doxycycline specifically was less commonly documented. 
Večina navedenih podatkov se je nanašala predvsem na odpornost na tetraciklin in ugotovljeno je bilo, da je odpornost na doksiciklin redkeje dokumentirana.
Do not use in case of hypersensitivity to the active substance or to any of excipients. 
Ne uporabljajte v primeru preobčutljivosti na zdravilno učinkovino ali na katero koli pomožno snov.
Poultry tolerate double overdoses of doxycycline (40 mg/kg body weight) without any clinical effect. 
Perutnina prenaša dvakraten odmerek doksiciklina (40 mg/kg) brez kakršnega koli kliničnega učinka.
The Marketing Authorisation Holder submitted a body of literature references which supported a prediction that when administered at the proposed dose rate, doxycycline concentration in the relevant tissues would exceed the MIC for most target pathogens. 
Imetnik dovoljenja za promet z zdravilom je predložil sklop literature, ki potrjuje pričakovanje, da bi pri uporabi predlaganega odmerka koncentracija doksiciklina v zadevnih tkivih presegla vrednost MIC za večino ciljnih patogenov.
Interactions with other medicinal products and other forms of interaction Do not combine with antibiotics that are bactericidal like penicillins or cephalosporins. 
Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Ne kombinirajte z antibiotiki, ki so baktericidni, kot so penicilini ali cefalosporini.
LABEL TEXT SINGLE SACHETS/BAGS 
BESEDILO ZA OZNAKE ENOJNIH VREČK
In pig pathogens resistance against doxycycline may also vary; especially susceptibility figures of A. pleuropneumoniae may differ from country to country and even farm to farm. 
Tudi pri prašičih lahko odpornost patogenov na doksiciklin niha; predvsem vrednosti za občutljivost A. pleuropneumoniae se lahko od države do države in celo od kmetije do kmetije razlikujejo.
Prescription only medicine - To be completed nationally. 
Zdravilo samo na veterinarski recept - Izpolni država članica .
Four resistance mechanisms acquired by microorganisms against tetracyclines in general have been reported: Decreased accumulation of tetracyclines (decreased permeability of the bacterial cell wall and active efflux), protein protection of the bacterial ribosome, enzymatic inactivation of the antibiotic and rRNA mutations (preventing the tetracycline binding to ribosome). 
Kar se pridobljene odpornosti mikroorganizmov proti tetraciklinu tiče, so poročali o štirih splošnih mehanizmih: Zmanjšano kopičenje tetraciklinov (zmanjšana prepustnost bakterijske celične stene in aktivni iztok), proteinska zaščita bakterijskega ribosoma, encimska inaktivacija antibiotika in rRNA mutacije (ki preprečujejo, da se tetraciklini vežejo na ribosom).
Composition per gram product: Active Substance: 
Sestava na gram izdelka: Aktivna snov:
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years Shelf-life after first opening the immediate packaging: 9 months Shelf-life after dilution or reconstitution according to directions: After reconstitution with water, any product remaining after 24 hours should be discarded. 
Rok uporabnosti zdravila za uporabo v veterinarski medicini v pakiranju za prodajo: 3 leta Rok uporabnosti po prvem odpiranju stične ovojnine: 9 mescev Rok uporabnosti po razredčenju ali rekonstituciji v skladu z navodili: Po rekonstituciji z vodo je treba po 24 urah preostanek izdelka zavreči.
PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGE Aluminium Foil Sachet 100g (packed per 10) 
PODATKI NA ZUNANJI OVOJNINI torbica iz aluminijeve folije 100g (pakirano po 10)
For O. rhinotracheale, no therapeutic dose could be confirmed. 
Za okužbo z O. rhinotracheale ni bilo mogoče potrditi terapevtskega odmerka.
Do not combine with antibiotics that are bacteriocidal e.g. penicillins or cephalosporins. 
Ne kombinirajte z antibiotiki, ki so baktericidni, kot so penicilini ali cefalosporini.
If you know you are allergic to the tetracycline class of antibiotics, special care should be taken when handling this product or the medicated solution. 
Če veste, da ste alergični na tetraciklinske antibiotike, je pri rokovanju z zdravilom ali s pripravljeno raztopino potrebna posebna previdnost .
The precautions to limit the development of resistance, which were recommended by CVMP during the Article 35 referral, have been included in section 4.5 of the SPC. 
Obvladovanje tveganja ali ukrepi za zmanjševanje tveganja Previdnostni ukrepi za zmanjševanje razvoja odpornosti, ki jih je priporočil CVMP med postopkom napotitve v skladu s členom 35, so bili vključeni v poglavje 4.5 povzetka glavnih značilnosti zdravila.
2 Bousquet et al. 1998, Pharmacokinetics of doxycycline in pigs following oral administration in feed Vet.Res. 
2 Bousquet et al. (1998): Pharmacokinetics of doxycycline in pigs following oral administration in feed.
Any unused veterinary medicinal product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements. 
Vse neporabljeno veterinarsko zdravilo ali odpadke, ki nastanejo iz tega veterinarskega zdravila, je treba odstraniti v skladu z lokalnimi predpisi.
PACKAGE SIZE 100 g (250 g, 500 g, 1 kg) 
VELIKOST PAKIRANJA 100 g (250 g, 500 g, 1 kg)
Doxycycline is primarily a bacteriostatic drug. 
Doksiciklin je predvsem bakteriostatično zdravilo.
To be completed nationally 
Izpolni država članica
Doxycycline is absorbed in the stomach and the first part of the duodenum. 
Doksiciklin se absorbira v želodcu in začetnem delu dvanajstnika.
Compared to the older tetracyclines the absorption of doxycycline is less affected by the presence of bivalent cations in food. 
V primerjavi s starejšimi tetraciklini ima prisotnost dvovalentnih kationov v hrani manj vpliva na absorpcijo doksiciklina.
Administration orally with the drinking water. 
Daje se oralno s pitno vodo.
Wash hands and contaminated skin immediately after handling the product. 
Po delu s proizvodom si takoj umijte roke in kontaminirano kožo.
TARGET SPECIES Pigs and chickens (broiler, pullet, breeder). 
CILJNE ŽIVALSKE VRSTE Prašiči in piščanci (brojler, kokoška, rejnica).
Significantly no cross resistance was observed between oxytetracycline and doxycycline. 
Pomembno je tudi, da ni bila opažena nobena navzkrižna odpornost med oksitetraciklinom in doksiciklinom.
= .... mg product per l drinking water 
= .... mg izdelka na l pitne vode
6 The ARBAO-II study, Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries form year 2002-2004, Acta Veterinaria Scandinavica 50(19) (2008) 
6 The ARBAO-II study, Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries form year 2002-2004.
Respiratory tract tissue: plasma ratios of 1.3 (healthy lungs), 1.9 (pneumonic lungs) and 2.3 (nasal mucosa) have been reported for doxycycline. 
Tkivo v dihalnem traktu: za doksiciklin navajajo razmerja v plazmi 1,3 (zdrava pljuča), 1,9 (pneumonična pljuča) in 2.3 (sluznica v nosu).
Carton box for the 10x100 grams Alufoil sachets with label for 100 gram sachets and leaflet 
Škatla za 10x100 gramske vrečke iz aluminijeve folije z oznako za 100 gramske vrečke in navodilo za uporabo
METHOD AND ROUTE(S) OF ADMINISTRATION To be administered orally in the drinking water. 
NAČIN IN POT(I) UPORABE Daje se peroralno v pitni vodi.
Composition per gram product Active Substance: 
Sestava na gram izdelka Aktivna snov:
In human medicine, doxycycline is the treatment of choice for the treatment of acute tracheobronchitis, acute bronchitis and acute bronchiolitis caused by primary bacterial infections (Mycoplasma pneumoniae, Chlamydia pneumoniae) and bacterial superinfections (Pneumococci, Haemophilus spp.). 
V humani medicini je doksiciklin zdravilo izbire za zdravljenje akutnega traheobronhitisa, akutnega bronhitisa in akutnega bronhiolitisa, ki ga povzročajo primarne bakterijske okužbe (Mycoplasma pneumoniae, Chlamydia pneumoniae) in sekundarne bakterijske okužbe (pnevmokoki, Haemophilus spp).
The chicken residue depletion data submitted allowed the setting of meat withdrawal periods in chickens. 
Predloženi podatki o izločanju ostankov pri piščancih so omogočili določitev karence za meso pri piščancih.
Do not use in animals with an impaired liver function. 
Ne uporabljajte pri živalih z okvaro jeter.
In response to this the Marketing Authorisation Holder submitted PSUR data covering the past 5 years. 
V odgovor je imetnik dovoljenja za promet z zdravilom predložil dopolnjeno redno poročilo o varnosti zdravila (PSUR), ki je zajemalo zadnjih pet let.
For the treatment of P. multocida, a dosage regimen of 10 mg/kg body weight for 4 or 5 days was agreed. 
Za zdravljenje okužb zaradi P. multocida je bil dogovorjen režim odmerjanja 10 mg/kg telesne mase 4 ali 5 dni.
Doxycycline is a broad-spectrum antibiotic, active against a large number of Gram-positive and Gramnegative, aerobe and anaerobe micro-organisms, Mycoplasmata, Chlamydiae and Rickettsia. 
Doksiciklin je antibiotik širokega spektra, učinkovit za obsežno skupino Gram-pozitivnih in Gramnegativnih, aerobnih in anaerobnih mikroorganizmov, kot so Mycoplasmata, Chlamydiae in Rickettsia.
In addition the Marketing Authorisation Holder submitted Periodic Safety Update Report (PSUR) data which indicated that no adverse events in chickens, including suspected lack of expected efficacy, has been reported for the past 5 years in the European Union. 
Poleg tega je imetnik dovoljenja za promet z zdravilom predložil dopolnjeno redno poročilo o varnosti zdravila (PSUR), ki je kazalo, da v zadnjih petih letih v Evropski uniji niso poročali o nobenih neželenih učinkih pri piščancih, vključno z domnevno manjšo učinkovitostjo od pričakovane.
Doxycycline is scarcely metabolised. 
Doksiciklin se komajda metabolizira.
Sachets of 100g, 250g, 500g and 1 kg and 10x 100g in a carton box. 
Vrečke s 100g, 250g, 500g in 1 kg in 10x 100g v kartonski škatli.
There have been no reports of adverse events in pigs, including suspected lack of expected efficacy, during the last 5 years. 
V zadnjih petih letih ni bilo nobenih poročil o neželenih učinkih pri prašičih, vključno z domnevno manjšo učinkovitostjo od pričakovane.
Chickens: Where clinical disease is present in the flock, to reduce mortality, morbidity, and clinical signs and to reduce lesions due to Pasteurellosis caused by Pasteurella multocida or to reduce morbidity and lesions in respiratory infections caused by Ornithobacterium rhinotracheale (ORT). 
Piščanci: kjer je v jati prisotno klinično obolenje, da se zmanjša smrtnost, obolevnost in klinične znake in da se zmanjša poškodbe zaradi pasteureloze, ki jo povzroča Pasteurella multocida, ali pa da se zmanjša morbidnost in poškodbe zaradi okužb dihal, ki jih povzroča Ornithobacterium rhinotracheale (ORT).
It was identified at the time of the Article 35 referral for water soluble powders and oral solutions containing doxycycline hyclate that a high resistance rate to tetracyclines existed in E. coli isolated from chickens (De Jong et al, 2009)5. 
V času napotitve v skladu s členom 35 je bilo za v vodi topne praške in peroralne raztopine, ki vsebujejo doksiciklinijev hiklat, ugotovljeno, da je obstajala visoka stopnja odpornosti na tetracikline pri bakteriji E.coli, izolirani iz piščancev (De Jong et al., 2009)5.