natgillin/translations-raw huggingface dataset:
• Sulphonamides (also called sulpha medicines) e.g. sulfamethoxazole - an antibiotic used to treat urinary infections, and sulfasalazine - used to treat Crohn's disease, ulcerative colitis and rheumatoid arthritis 
• sulfonamidi (imenovani tudi sulfa-zdravila), npr. sulfametoksazol - antibiotik, ki se uporablja za zdravljenje okužb sečil, in sulfasalazin - uporablja se za zdravljenje Crohnove bolezni, ulceroznega kolitisa in revmatoidnega artritisa;
Fortacin may also come into contact with other mucous membranes such as your, or your partner's, mouth, nose and throat, causing them to feel slightly numb for a short while. 
Zdravilo Fortacin lahko pride v stik tudi z drugimi sluznicami, na primer ust, nosu in žrela vas ali vaše partnerke, kar za kratek čas povzroči rahlo omrtvelost.
A study in rats showed that Fortacin caused a reduction in sperm motility. 
V študiji na podganah so zabeležili, da je zdravilo Fortacin povzročilo zmanjšanje gibljivosti semenčic.
Patients allergic to paraaminobenzoic acid derivatives (procaine, tetracaine, benzocaine, etc.) have not shown cross sensitivity to lidocaine and/or prilocaine; however, Fortacin should be used with caution in patients with a history (or partner with a history) of sensitivities to medicinal products, especially if the aetiologic medicinal product is uncertain. 
Pri bolnikih, ki so alergični na derivate paraaminobenzojske kisline (prokain, tetrakain, benzokain itd.), niso zabeležili navzkrižne občutljivosti na lidokain in/ali prilokain; vendar je potrebna previdnost pri uporabi zdravila Fortacin pri bolnikih (ali njihovih partnerkah) s preobčutljivostmi na zdravila v anamnezi, zlasti kadar etiologija zdravila ni znana.
If contact with the eye occurs, immediately rinse the eye with water or sodium chloride solution and protect it until sensation returns. 
Če pride do stika z očmi, prizadeto oko takoj izperite z vodo ali raztopino natrijevega klorida ter oko zaščitite, dokler se čut ne povrne.
Prilocaine was not genotoxic and the carcinogenic potential of prilocaine has not been studied. 
Prilokain Prilokain ni bil genotoksičen in karcinogeni potencial prilokaina ni bil raziskan.
As this medicine is applied to the surface of the head of the penis the risk of overdose is low. 
Ker se to zdravilo nanese na površino glavice penisa, je tveganje za preveliko odmerjanje nizko.
Caution is advised in case of severe hepatic impairment (see section 4.4). 
V primeru hude jetrne okvare je potrebna previdnost (glejte poglavje 4.4).
Patients on anti-arrhythmic medicinal products class III (e.g. amiodarone) should be treated with caution. 
Pri zdravljenju bolnikov, ki prejemajo antiaritmike razreda III (npr. amiodaron), je potrebna previdnost.
Following intravenous administration, the steady state volume of distribution of prilocaine is 0.7 to 4.4 L/kg. 
Po intravenskem dajanju je volumen porazdelitve v stanju dinamičnega ravnovesja 0,7 do 4,4 l/kg.
Although the systemic availability of prilocaine by cutaneous absorption of Fortacin is low, caution should be exercised in patients with anaemia, congenital or acquired methaemoglobinaemia or patients on concomitant therapy known to produce such conditions. 
Čeprav je sistemska razpoložljivost prilokaina z dermalno absorpcijo zdravila Fortacin nizka, je potrebna previdnost pri bolnikih z anemijo, prirojeno ali pridobljeno methemoglobinemijo in pri bolnikih, ki prejemajo sočasno zdravljenje, za katerega je znano, da povzroča takšna stanja.
Embryotoxicity was observed in rabbits at doses toxic to the mother. 
Embriotoksičnost so opazili pri kuncih pri odmerkih, toksičnih za mater.
• Benzocaine - a local anaesthetic used to treat pain and itching 
• benzokain - lokalni anestetik, ki se uporablja za zdravljenje bolečin in srbenja;
In vitro interaction studies with topical antifungal (clotrimazole, econazole, imidazole, nystatin, miconazole, ketoconazole), antibacterial (clindamycin, metronidazole) and antiviral medicinal products (acyclovir), showed no effect on antimicrobial activity. 
Študije medsebojnega delovanja in vitro z lokalnimi antimikotiki (klotrimazol, ekonazol, imidazol, nistatin, mikonazol, ketokonazol), antibakteriki (klindamicin, metronidazol) in antivirotiki (aciklovir) niso pokazale vpliva na protimikrobno delovanje.
In a study of pregnant rats receiving a combination of lidocaine and prilocaine during organogenesis, no effects on embryonic/foetal development were observed. 
V študiji brejih podgan, ki so med organogenezo prejemale kombinacijo lidokaina in prilokaina, niso opazili nobenih učinkov na razvoj zarodka/ploda.
In Fortacin-treated subjects, IELT and IPE scores increased at the first measured timepoint. 
Pri preiskovancih, ki so prejemali zdravilo Fortacin, so se rezultati IELT in IPE povišali pri prvi izmerjeni časovni točki.
The recommended dose is 3 actuations applied to cover the glans penis. 
Priporočen odmerek je 3 potiske, s katerimi se prekrije glavico penisa.
Hypoaesthesia of male genital, erectile dysfunction, genital burning sensation 
Hipestezija moških spolovil, erektilna disfunkcija, pekoč občutek spolovil
• discomfort in the anus and rectum 
• neprijeten občutek v anusu in rektumu
In an in vitro study of rats Fortacin has shown a reduction in sperm motility when 22.5 mg lidocaine and 7.5 mg prilocaine (i.e. the amount in 1 human dose) was in direct contact with rat sperm. 
V študiji in vitro pri podganah je zdravilo Fortacin zmanjšalo gibljivost semenčic, kadar je bil odmerek 22,5 mg lidokaina in 7,5 mg prilokaina (tj. količina 1 odmerka pri človeku) v neposrednem stiku s podganjo spermo.
You must throw away the container 12 weeks after you first use it. 
12 tednov po prvi uporabi morate vsebnik zavreči.
Lidocaine is reported to be 66% bound by plasma proteins, including alpha-1-acid glycoprotein. 
Lidokain se veže na plazemske beljakovine (66 %), vključno z alfa-1-kislim glikoproteinom.
• Sodium nitroprusside, isosorbide dinitrate - used to treat high blood pressure and heart failure 
• natrijev nitroprusid, izosorbid dinitrat - uporabljata se za zdravljenje visokega krvnega tlaka in srčne odpovedi;
Clinical trials have shown Fortacin to increase the intra-vaginal ejaculatory latency time (IELT), increase control over ejaculation and reduce the feelings of distress in patients with premature ejaculation as measured by the Index of Premature Ejaculation (IPE). 
V kliničnih preskušanjih so zabeležili, da zdravilo Fortacin poveča trajanje intravaginalne ejakulacijske latence (IELT), poveča nadzor nad ejakulacijo ter zmanjša občutek osebne stiske pri bolnikih s prezgodnjo ejakulacijo, kar so izmerili z indeksom prezgodnje ejakulacije (Index of Premature
• Glyceryl trinitrate (GTN, nitroglycerin), isosorbide mononitrate, erythrityl tetranitrate, pentaerythritol tetranitrate and other nitrate and nitrite medicines - used to treat angina (chest pain caused by the heart) 
• glicerin trinitrat (GTN, nitroglicerin), izosorbid mononitrat, eritritil tetranitrat, pentaeritritol tetranitrat in druga zdravila, ki vsebujejo nitrate in nitrite - uporabljajo se za zdravljenje angine pektoris (bolečine v prsih, ki jo povzroča srce);
Prilocaine in high doses may cause an increase in the methaemoglobin level particularly in conjunction with methaemoglobin-inducing agents (e.g. sulphonamides). 
Visoki odmerki prilokaina lahko povzročijo zvišanje ravni methemoglobina, zlasti skupaj s snovmi, ki povečujejo koncentracije methamoglobina (npr. sulfonamidi).
In a carcinogenicity study of rats exposed to 2,6-xylidine in utero, postnatally and throughout their lifetime, tumours in the nasal cavity, subcutaneous tumours and liver tumours were observed. 
V študiji karcinogenosti pri podganah, izpostavljenih 2,6-ksilidinu in utero po povrženju in skozi celotno življenjsko dobo, so opazili tumorje v nosni votlini,
There are no adequate data from the use of lidocaine and prilocaine on fertility in humans. 
Ni zadostnih podatkov o vplivu uporabe lidokaina in prilokaina na plodnost pri ljudeh.
The prilocaine metabolite o-toluidine has genotoxic potential in vitro. 
o-toluidin, ima genotoksičen potencial in vitro.
If you use more Fortacin than you should 
Če ste uporabili večji odmerek zdravila Fortacin, kot bi smeli:
One third of the glans penis should be covered with each actuation. 
Z vsakim potiskom je treba prekriti eno tretjino glavice penisa.
The clinical relevance of tumour findings in relation to short-term/intermittent use of lidocaine in humans is unknown. 
Klinični pomen opaženih tumorjev v povezavi s kratkoročno/občasno uporabo lidokaina pri ljudeh ni znan.
Within each frequency grouping, adverse reactions are presented in order of decreasing incidence. 
V razvrstitvah pogostnosti so neželeni učinki navedeni po padajoči resnosti.
The lidocaine metabolite 2,6-xylidine has genotoxic potential in vitro. 
2,6-ksilidin ima genotoksičen potencial in vitro.
If you or your sexual partner get any side effects, talk to your doctor or pharmacist. 
Če vi ali vaša spolna partnerka opazite kateri koli neželeni učinek, se posvetujte z zdravnikom ali farmacevtom.
The efficacy of Fortacin was demonstrated in two multi-centre, multinational, randomised, double-blind, placebo controlled studies, both followed by an open-label phase. 
randomiziranih, dvojno slepih, s placebom kontroliranih študijah, ki jima je sledila odprta faza.
The effectiveness of Fortacin in treating PE was assessed by measuring IELT and the co primary endpoints of ejaculatory control, sexual satisfaction, and distress using the IPE. 
Učinkovitost zdravila Fortacin pri zdravljenju prezgodnje ejakulacije so ocenili z merjenjem IELT in soprimarnih končnih točk nadzora nad ejakulacijo, zadovoljstva s spolnim odnosom in osebne stiske z uporabo IPE.
There is no relevant use of Fortacin in the paediatric population for the indication of treatment of primary premature ejaculation in adult men. 
Ustrezne uporabe zdravila Fortacin pri pediatrični populaciji za indikacijo zdravljenja primarne prezgodnje ejakulacije pri odraslih moških ni.
Prilocaine is rapidly metabolised in both the liver, by cytochrome P450, and in the kidneys by amidases. 
Prilokain se hitro presnovi v jetrih s citokromom P450 in v ledvicah z amidazo.
• a high temperature 
Povišana telesna temperatura
Uncommon Vaginal candidiasis 
Vaginalna kandidiaza
Clinical studies have not been performed in patients with impaired renal function, however due to its method of administration and very low systemic absorption, no dosage adjustment is required. 
Pri bolnikih z okvarjenim delovanjem ledvic klinične študije niso bile izvedene, vendar zaradi načina uporabe in zelo nizke sistemske absorpcije prilagajanje odmerkov ni potrebno.
The postnatal survival time of the offspring of rats treated during pregnancy and lactation with a dose toxic to the mother was shown to be reduced. 
Zabeležili so skrajšani čas preživetja po povrženju potomcev podgan, ki so prejemale zdravljenje med brejostjo in laktacijo z odmerkom, toksičnim za mater.
Fortacin may reduce the possibility of pregnancy, but is not a reliable contraceptive. 
Plodnost Zdravilo Fortacin lahko zmanjša možnost zanositve, vendar ni zanesljiv kontraceptiv.
• local irritation of the throat (if inhaled) 
• lokalno draženje žrela (pri vdihavanju);
Lidocaine is excreted in the urine mainly as metabolites, with only a small proportion excreted unchanged. 
Lidokain se izloča z urinom v glavnem v obliki presnovkov, le majhen delež pa se izloči v nespremenjeni obliki.
Prilocaine is reported to be 55% bound to plasma proteins, including alpha-1-acid glycoprotein. 
Prilokain se veže na plazemske beljakovine (55 %), vključno z alfa-1-kislim glikoproteinom.
Fortacin is a colourless to light yellow cutaneous spray, solution in an aluminium spray container with metering valve. 
Zdravilo Fortacin je brezbarvna do svetlo rumena raztopina za dermalno pršilo v aluminijastem vsebniku s pršilom z odmernim ventilom.
• Metoclopramide - used to treat feelings of sickness (nausea) and vomiting, including in patients with migraine 
• metoklopramid - uporablja se za zdravljenje občutka slabosti (navzea) in bruhanja, vključno pri bolnikih z migrenami;
Severe neurological symptoms (convulsions, CNS depression) must be treated symptomatically by respiratory support and the administration of anticonvulsive medicinal products. 
Hujše nevrološke simptome (konvulzije, depresijo osrednjega živčnega sistema) je treba zdraviti simptomatsko z umetno ventilacijo in dajanjem antiepileptikov.
Aluminium spray container with metering valve. 
Aluminijast vsebnik s pršilom z odmernim ventilom.
Male volunteers had maximum plasma concentrations of lidocaine which were less than 4% of toxic levels, and prilocaine which were less than 0.4% of toxic levels, after repeat dosing. 
Moški prostovoljci so imeli po ponavljajočih se odmerkih najvišje ravni lidokaina v plazmi, ki so bile nižje od 4 % toksičnih ravni, in največje ravni prilokaina v plazmi, ki so bile nižje od 0,4 % toksičnih ravni.
In serious cases of overdose, symptoms may include fits, low blood pressure, slowed breathing, stopped breathing and altered heart beat. 
V hujših primerih prevelikega odmerjanja lahko med simptome spadajo krči, nizek krvni tlak,
Effect on fertility 
Vpliv na plodnost
• discomfort or itching in the vulva and vagina 
• neprijeten občutek ali srbenje v vulvi in nožnici.
Lidocaine can cross the blood brain barrier and the placenta and is distributed in breast milk. 
Lidokain prehaja skozi krvnomožgansko pregrado in placento ter se izloča v materino mleko.
Men satisfying the International Society for Sexual Medicine (ISSM) criteria for premature ejaculation (PE) who had a baseline IELT ≤ 1 minutes in at least 2 of the first 3 sexual encounters during screening were eligible to enrol. 
V študiji so lahko sodelovali moški, ki so izpolnjevali merila Mednarodnega združenja za spolno medicino (International Society for Sexual Medicine, ISSM) glede prezgodnje ejakulacije (PE) z začetno vrednostjo trajanja intravaginalne ejakulacijske latence (IELT) ≤ 1 minuta pri vsaj 2 od prvih 3
The clinical relevance of tumour findings in respect of short-term/intermittent use of prilocaine in humans is unknown. 
Klinični pomen opaženih tumorjev v povezavi s kratkoročno/občasno uporabo prilokaina pri ljudeh ni znan.
Prilocaine is excreted in the urine mainly as its metabolites, with only a small proportion excreted unchanged. 
Prilokain se izloča z urinom v glavnem v obliki presnovkov, le majhen delež pa se izloči v nespremenjeni obliki.
• medicines for high blood pressure and to regulate your heart rhythm (so-called beta blockers) 
• zdravila proti visokemu krvnemu tlaku in zdravila za uravnavanje srčnega ritma (t. i.
Ask your pharmacist if you are unsure. 
Če niste prepričani, vprašajte svojega farmacevta.
Systemic exposure to lidocaine and prilocaine and their metabolites (respectively 2,6-xylidine and o-toluidine), is low following application to the glans penis in male patients and application to the cervix/vagina fornices in female subjects, at doses higher than recommended. 
Sistemska izpostavljenost lidokainu in prilokainu ter njunim presnovkom (2,6-ksilidin in o-toluidin) je po nanosu na glavico penisa pri moških bolnikih in po nanosu na forniks materničnega vratu/nožnice pri ženskih preiskovancih pri odmerkih, višjih od priporočenih, nizka.
After 5 minutes any excess spray should be wiped off prior to intercourse. 
Po 5 minutah je treba vse odvečno pršilo pred spolnim odnosom obrisati.
- The active substances are lidocaine and prilocaine. 
- Učinkovini sta lidokain in prilokain.
Fortacin sprayed onto a damaged tympanic membrane may cause ototoxicity of the middle ear. 
Če se zdravilo Fortacin razprši na poškodovan ušesni bobnič, lahko to povzroči ototoksičnost srednjega ušesa.
These adverse reactions caused discontinuation of treatment in 0.2% and 0.5% of patients, respectively. 
Zaradi hipestezije spolovil je prišlo do prekinitve zdravljenja pri 0,2 % bolnikov in zaradi erektilne disfunkcije pri 0,5 % bolnikov.
Cutaneous spray, solution Colourless to light yellow solution 
dermalno pršilo, raztopina Brezbarvna do svetlo rumena raztopina
Patients or their partner with glucose-6-phosphate dehydrogenase deficiency or congenital or idiopathic methaemoglobinaemia are more susceptible to medicinal product-induced methaemoglobinaemia (see section 4.5). 
Stanja, povezana z anemijo Bolniki ali njihove partnerke s pomanjkanjem glukoza-6-fosfat dehidrogenaze ali prirojeno ali idiopatično methemoglobinemijo so dovzetnejši za methemoglobinemijo zaradi uporabe zdravil (glejte poglavje 4.5).
• Nitrofurantoin - an antibiotic used to treat urinary and kidney infections 
• nitrofurantoin - antibiotik, ki se uporablja za zdravljenje okužb sečil in ledvic;
The following side effects have been reported with Fortacin in male patients: 
Pri uporabi zdravila Fortacin so poročali o naslednjih neželenih učinkih pri moških bolnikih:
Patients hoping to achieve conception should either avoid using Fortacin, or, if it is essential to achieve penetration, should wash the glans penis as thoroughly as possible prior to intercourse. 
Bolniki, ki želijo spočeti otroka, naj se izogibajo uporabi zdravila Fortacin, če je njegova uporaba nujna za dosego penetracije, pa naj si pred spolnim odnosom čim temeljiteje sperejo glavico penisa.
Patients with severe hepatic disease, because of their inability to metabolise local anaesthetics normally, are at greater risk of developing toxic plasma concentrations of lidocaine and prilocaine (see section 4.2). 
Pri bolnikih s hudo jetrno boleznijo obstaja večje tveganje za razvoj toksičnih koncentracij lidokaina in prilokaina v plazmi zaradi nezmožnosti normalne presnove lokalnega anestetika (glejte poglavje 4.2).
Fortacin is indicated for the treatment of lifelong premature ejaculation in adult men. 
Zdravilo Fortacin je indicirano za zdravljenje vseživljenjske prezgodnje ejakulacije pri odraslih moških.
What Fortacin looks like and contents of the pack 
Izgled zdravila Fortacin in vsebina pakiranja
The risk of additional systemic toxicity should be considered when large doses of Fortacin are applied to patients already using other local anaesthetics or structurally related medicinal products, e.g. class I anti-arrhythmics such as mexiletine. 
Pri nanosu večjih količin zdravila Fortacin pri bolnikih, ki že uporabljajo druge lokalne anestetike ali strukturno povezana zdravila, npr. antiaritmike razreda I kot meksiletin, je treba upoštevati tveganje za dodatno sistemsko toksičnost.
Wait 5 minutes then wipe off any excess spray prior to having sexual intercourse. 
Počakajte 5 minut, nato pa pred spolnim odnosom obrišite odvečno pršilo.
There are no or limited amount of data from the use of lidocaine and prilocaine in pregnant women. 
Podatkov o uporabi lidokaina in prilokaina pri nosečnicah ni oziroma so omejeni.
Holding the can upright (valve up), apply 1 dose (3 sprays) of Fortacin to the entire head of the penis, by covering one third with each spray. 
Vsebnik držite navzgor (ventil obrnjen navzgor) in na celotno glavico penisa nanesite 1 odmerek (3 razpršitve) zdravila Fortacin, tako da z vsako razpršitvijo prekrijete eno tretjino.
If some medicine accidentally gets into your eyes or your partner's eyes, rinse them immediately with cold water or saline solution and cover them gently until any effects, such as numbness, wear off. Be aware that normal protective mechanisms, such as blinking, or sensation of a foreign body in the eye, may not occur until the numbness has worn off. 
Če nekaj zdravila po nesreči pride v stik z vašimi očmi ali očmi vaše partnerke, jih takoj izperite s hladno vodo ali fiziološko raztopino in jih nežno prekrijte, dokler učinki, na primer omrtvelost, ne izginejo.
Cutaneous spray, solution 6.5 ml 
dermalno pršilo, raztopina 6,5 ml
Each dose consists of a total of 22.5 mg lidocaine and 7.5 mg prilocaine per application (1 dose is equal to 3 actuations). 
En odmerek vsebuje skupno 22,5 mg lidokaina in 7,5 mg prilokaina na nanos (1 odmerek je enak 3 potiskom).
As Fortacin is applied topically to the glans penis the risk of overdose is low. 
Ker se zdravilo Fortacin nanaša lokalno na glavico penisa, je tveganje za preveliko odmerjanje nizko.
• feeling of burning in and around the vagina • reduced feeling in and around the vagina 
• pekoč občutek v nožnici in okrog nje; • zmanjšano čutenje v nožnici in okrog nje.
The following side effects have been reported with Fortacin in female partners: 
Pri uporabi zdravila Fortacin so poročali o naslednjih neželenih učinkih pri partnerkah:
Fortacin provides topical anaesthesia to the glans penis. 
Zdravilo Fortacin zagotavlja lokalno anestezijo glavice penisa.
The steady-state volume of distribution is 1.1 to 2.1 L/kg after intravenous administration. 
Po intravenskem dajanju je volumen porazdelitve v stanju dinamičnega ravnovesja 1,1 do 2,1 l/kg.
Hypersensitivity of the patient or their partner to the active substances or to any of the excipients listed in section 6.1. 
Preobčutljivost bolnika ali njegove partnerke na zdravilni učinkovini ali katero koli pomožno snov,
A residual volume of fluid that is not usable will remain in the container after all doses have been administered. 
Po uporabi vseh odmerkov v vsebniku ostane preostali volumen tekočine, ki je ni več mogoče uporabiti.
PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING SPRAY CONTAINER LABEL 
PODATKI NA PRIMARNI OVOJNINI NALEPKA NA VSEBNIKU S PRŠILOM
Therefore, patients hoping to achieve conception should either avoid using Fortacin, or, if this medicine is essential to achieve penetration, should wash the penis as thoroughly as possible five minutes after Fortacin has been applied, but prior to intercourse. 
Zato naj se bolniki, ki želijo spočeti otroka, izogibajo uporabi zdravila Fortacin, če je uporaba tega zdravila nujna za dosego penetracije, pa naj si pet minut po nanosu zdravila Fortacin, vendar pred spolnim odnosom,
Before initial use, briefly shake the spray container and then prime the pump mechanism by spraying the valve three times into the air. 
Pred prvo uporabo na kratko pretresite vsebnik s pršilom, nato pa črpalni mehanizem aktivirajte tako, da zdravilo trikrat razpršite v zrak.
Fortacin is indicated for the treatment of primary premature ejaculation in adult men. 
Zdravilo Fortacin je indicirano za zdravljenje primarne prezgodnje ejakulacije pri odraslih moških.
• irritation of the skin 
• draženje kože;
Prilocaine crosses the blood-brain barrier and also crosses the placenta. 
Prilokain prehaja skozi krvnomožgansko pregrado in tudi skozi placento.
Plasma levels of these metabolites detected after administration of Fortacin in clinical trials were low in both male and female subjects, even after doses of it many times in excess of the clinical dose were applied. 
Fortacin v kliničnih preskušanjih, so bile nizke pri moških in tudi ženskih preiskovancih celo pri nanosu odmerkov, veliko večjih od kliničnega.
Before each subsequent use, it should be briefly shaken and then the spray container should be re-primed by spraying it once. 
Pred vsako naslednjo uporabo ga je treba na kratko pretresti, znova pa se aktivira z eno razpršitvijo.
Contents of the pack and other information 
Shranjevanje zdravila Fortacin Vsebina pakiranja in dodatne informacije
• vaginal thrush (Candida) infection 
• okužba nožnice (soor) s kandido;
The clinically significant increases in IELT were paralleled by significant differences in the IPE scores (p <0.0001). 
Klinično pomembna povečanja IELT so sovpadala z občutnimi razlikami med rezultati IPE
Each ml of solution contains 150 mg lidocaine and 50 mg prilocaine. 
En ml raztopine vsebuje 150 mg lidokaina in 50 mg prilokaina.
• Tingling of the skin around the mouth and numbness of the tongue 
• omotičnost ali vrtoglavost; • mravljinčenje kože okrog ust in omrtvelost jezika;
First pass metabolism is rapid and extensive and bioavailability is about 35% after oral doses. 
Po peroralnih odmerkih je biološka uporabnost približno 35 %.