natgillin/translations-raw huggingface dataset:
EPZ104057 (HEAT study) was a randomised, double-blind, placebo-matched, 96 week, multi-centre study with the primary objective of evaluating the relative efficacy of abacavir/lamivudine (ABC/3TC, 600mg/300mg) and tenofovir /emtricitabine (TDF/FTC, 300mg/200mg), each given once-daily in combination with lopinavir/ritonavir (LPV/r, 800mg/200mg) in HIV-infected, therapy-naive adults. 
Njen primarni cilj je bila ocena relativne učinkovitosti zdravljenja z abakavirjem/lamivudinom (ABC/3TC, 600 mg/300 mg) ter tenofovirjem/emtricitabinom (TDF/FTC, 300 mg/200 mg).
The M184V or M184I variants arise in HIV-1 infected patients treated with lamivudine-containing antiretroviral therapy. 
Protivirusno zdravljenje glede na genotipsko/fenotipsko odpornost Odpornost in vivo (bolniki, ki še niso bili zdravljeni) Pri z virusom HIV-1 okuženih bolnikih, ki so se zdravili s protiretrovirusnim zdravljenjem, ki je vsebovalo lamivudin, sta se pojavili varianti M184V ali M184I.
Elderly: 
Starostniki:
Rare side effects that may show up in blood tests are: • increase in an enzyme called amylase. 
Redek neželeni učinek, ki se lahko pokaže v preiskavah krvi, je:
• presence of skin rash; OR 
• izpuščaj na koži;
ABC/3TC FDC QD (n=94) 
ABC/3TC + EFV (n =192)
The metabolites and unchanged abacavir account for about 83% of the administered abacavir dose in the urine. 
Približno 83 % prejetega odmerka abakavirja se izloči v obliki presnovkov ali v nespremenjeni obliki z urinom, ostanek se izloči z blatom.
Abacavir-resistant isolates of HIV-1 have been selected in-vitro in wild-type strain HIV-1 (HXB2) and are associated with specific genotypic changes in the RT codon region (codons M184V, K65R, L74V and Y115). 
Povezani so bili s specifičnimi genotipskimi spremembami kodonskega področja (kodoni M184V, K65R, L74V and Y115) RT. Selekcija za mutacijo M184V se je pojavila prva in je povzročila 2-kratno povečanje IC50.
• development of 1 or more symptom from at least 2 of the following groups: - Fever - Shortness of breath, sore throat or cough - Nausea or vomiting or diarrhoea or abdominal pain - Extreme tiredness or achiness or general ill feeling 
povišana telesna temperatura težko dihanje, vnetje žrela ali kašelj navzea ali bruhanje ali driska ali bolečine v trebuhu izredna utrujenost ali bolečnost ali splošno slabo počutje
Overall response (stratified by baseline HIV-1 RNA) Response by Baseline HIV-1 RNA <100,000 c/ml Response by Baseline HIV-1 RNA ≥100,000 c/ml 
RNA < 100.000 kopij/ml Odziv po izhodiščni HIV-1
Uncommon: Neutropenia and anaemia (both occasionally severe), thrombocytopenia Very rare: Pure red cell aplasia 
Občasni: nevtropenija in anemija (občasno obe hudi),
Therapy-naïve patients 
Predhodno še nezdravljeni bolniki
For patients receiving lamivudine 300 mg once daily, the terminal intracellular half-life of lamivudine-TP was prolonged to 16-19 hours, compared to the plasma lamivudine half-life of 5-7 hours. 
+ 32%, Cmax24,ss + 99% in Ctrough + 18%) kot pri režimu odmerjanja 300 mg dvakrat na dan.Pri bolnikih, ki so prejemali lamivudin v odmerku 300 mg enkrat dnevno, je bil terminalni znotrajcelični razpolovni čas lamivudin-TP 16-19 ur, razpolovni čas lamivudina v plazmi pa 5-7 ur.
Common side effects These may affect up to 1 in 10 people: 
Pojavijo se lahko pri največ 1 od 10 bolnikov:
The proportion of treatment-experienced patients in the CAL30001 study with HIVRNA <50 copies/mL at Week 48 by genotypic sensitivity score in optimized background therapy (OBT) are tabulated The impact of major IAS-USA defined mutations to abacavir or lamivudine and multi-NRTI resistance associated mutations to the number of baseline mutations on response was also evaluated. 
V preglednici so za študijo CAL30001 prikazani deleži že zdravljenih bolnikov, ki so imeli 48. teden HIV-RNA < 50 kopij/ml, po genotipski občutljivosti pri optimiziranem osnovnem zdravljenju.
ANTICONVULSANTS Phenobarbital/Abacavir 
ANTIEPILEPTIKI fenobarbital/abakavir
• headache 
• driska;
You should immediately contact your doctor if you think you are having a hypersensitivity reaction to Kivexa. 
Če mislite, da imate preobčutljivostno reakcijo na zdravilo Kivexa, se morate nemudoma posvetovati s svojim zdravnikom.
Write your doctor's details below: 
Nemudoma se posvetujte z zdravnikom:
• stiffness in the joints 
• togost sklepov;
infection 
Bolezni živčevja
At week 48, a lower rate of virologic response was observed for ABC/3TC compared to TDF/FTC (point estimate for the treatment difference: 11.6%, 95% CI: 2.2, 21.1). 
Po 48 tednih so s shemo ABC/3TC ugotovili manjši delež virološkega odziva kot s TDF/FTC
• cough 
Ziagen).
Contact your doctor immediately: 1 if you get a skin rash, OR 2 if you get symptoms from at least 2 of the following groups: fever shortness of breath, sore throat or cough nausea or vomiting, diarrhoea or abdominal pain severe tiredness or achiness, or generally feeling ill. 
1 če se vam pojavi izpuščaj na koži ALI 2 če se vam pojavijo simptomi iz vsaj 2 od naslednjih skupin:
Elderly 
diareja
This should take approximately 30 minutes. 
To traja približno 30 minut.
This is done by your doctor or a nurse, who will also monitor you during that time. 
To stori zdravnik ali medicinska sestra, ki vas med tem tudi nadzoruje.
The majority of these events were reported as either mild or moderate. 
O teh dogodkih so večinoma poročali kot o blagih ali zmernih.
Adults > 30 years 
Odrasli > 30 let
Clinical safety and efficacy 
Klinična varnost in učinkovitost
It is especially important to tell your doctor if you are taking medicines containing any of the following active substances: 
Še posebej pomembno je, da zdravnika obvestite, če jemljete zdravila, ki vsebujejo katero od naslednjih zdravilnih učinkovin:
It has similar immunostimulatory effects as natural MDP. 
Ima podobne imunostimulativne učinke kot naravni MDP.
This includes medicines that may be obtained without a prescription. 
To velja tudi za zdravila, ki jih lahko dobite brez recepta.
Supportive measures should be based on institutional guidelines and the clinical symptoms observed. 
Podporni ukrepi morajo temeljiti na institucionalnih smernicah in opaženih kliničnih simptomih.
Date of first authorisation: 6 March 2009 Date of latest renewal: 20 February 2019 
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve: 6. marec 2009 Datum zadnjega podaljšanja: 20. februar 2019
Do not use this medicine if you notice any visible signs of deterioration. 
Tega zdravila ne uporabljajte, če opazite kakršne koli vidne znake kvarjenja.
The safety and efficacy of mifamurtide in children aged 0 to 2 years have not been established. 
Varnost in učinkovitost mifamurtida pri otrocih, starih od 0 do 2 let, nista bili dokazani.
Therefore, there are not sufficient data to recommend the use of MEPACT in patients > 30 years of age. 
Zato ne obstajajo zadostni podatki, da bi lahko priporočili uporabo zdravila MEPACT pri bolnikih, starejših od 30 let.
Dose and duration of treatment 
Odmerjanje in trajanje zdravljenja
Specific studies addressing reproductive function, perinatal toxicity and carcinogenic potential have not been performed. 
Posebne študije glede reproduktivne funkcije, perinatalne toksičnosti in karcinogenega potenciala niso bile izvedene.
Safety and efficacy have been assessed in studies of patients 2 to 30 years of age at initial diagnosis (see section 5.1). 
Varnost in učinkovitost sta bili ocenjeni v študijah pri bolnikih, starih od 2 do 30 let ob prvotni diagnozi (glejte poglavje 5.1).
In the event of such an overdose, contact your doctor or nearest hospital. 
V primeru prevelikega odmerka se obrnite na zdravnika ali najbližjo bolnišnico.
In the event of an overdose, it is recommended that appropriate supportive treatment be initiated. 
V primeru prevelikega odmerka se priporoča uvedba ustreznega podpornega zdravljenja.
Do not use MEPACT: - if you are allergic to mifamurtide or any of the other ingredients of this medicine (listed in section 6). 
Ne uporabljajte zdravila MEPACT: - če ste alergični na mifamurtid ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
It is not recommended to give this medicine to children below the age of 2 years because information on how safe and how well this medicine works is not available for this age group. 
Tega zdravila ni priporočljivo uporabljati pri otrocih, mlajših od 2 let, saj podatki o varnosti in učinkovitosti tega zdravila pri tej starostni skupini niso na voljo.
The second episode involved multiple grand mal seizures over the course of days. 
Druga epizoda je vključevala več grand mal napadov čez cel dan.
If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby, ask your doctor for advice before taking this medicine. 
Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujete s svojim zdravnikom, preden vzamete to zdravilo.
Frequency groupings are defined according to the following convention: very common (≥ 1/10), common (≥ 1/100 to < 1/10), not known (cannot be estimated from the available data). 
Skupine pogostnosti so opredeljene skladno z naslednjim dogovorom: zelo pogosti ( 1/10), pogosti ( 1/100 do < 1/10), neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov).
During this time the liposomes are formed spontaneously (figure 2). 
V tem času samodejno nastajajo liposomi (slika 2).
None of the patients treated in the osteosarcoma studies were 65 years or older and in the phase III randomised study, only patients up to the age of 30 years were included. 
Nobeden od bolnikov, ki so se zdravili v okviru študij o osteosarkomu, ni bil star 65 let ali več, v randomizirano študijo III. faze pa so bili vključeni le bolniki, mlajši od 30 let.
There were no results from general toxicity studies that suggested harmful effects on male or female reproductive organs. 
Študije splošne toksičnosti niso dale nobenih rezultatov, ki bi kazali na škodljive učinke na moške ali ženske reproduktivne organe.
The excretion of mifamurtide in milk has not been studied in animals. 
Izločanje mifamurtida v mleko ni bilo raziskano pri živalih.
Adverse reactions are classified according to system organ class and frequency. 
Neželeni učinki so razvrščeni glede na organski sistem in pogostnost.
The liposomes were phagocytosed by cells of the reticuloendothelial system. 
Liposome so fagocitirale celice retikuloendotelijskega sistema.
If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 6 hours at room temperature. 
Če ni uporabljeno takoj, je za čas shranjevanja in pogoje pred uporabo odgovoren uporabnik, ta čas pa običajno ne sme preseči 6 ur pri sobni temperaturi.
Mifamurtide was not mutagenic and did not cause teratogenic effects in rats and rabbits. 
Mifamurtid ni bil mutagen in ni povzročil teratogenih učinkov pri podganah in kuncih.
Do not use this medicine after the expiry date which is stated on the vial label and the carton after “EXP”. 
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki na viali in škatli poleg oznake »EXP«.
Materials provided in each package 
Materiali, priloženi v vsakem pakiranju
In 2 of 4 patients with lung metastases, radioactivity was associated with lung metastases. 
Pri 2 od 4 bolnikov s pljučnimi metastazami je bila radioaktivnost povezana s pljučnimi metastazami.
MEPACT has a moderate influence on the ability to drive and use machines. 
Zdravilo MEPACT ima zmeren vpliv na sposobnost vožnje in upravljanja strojev.
Pharmacotherapeutic group: Immunostimulants, Other immunostimulants, ATC code: L03AX15 
Farmakoterapevtska skupina: Zdravila za spodbujanje imunske odzivnosti, Drugi imunostimulanti, oznaka ATC: L03AX15
Detailed information on warnings and precautions relating to side effects that could occur while you are taking the medicine is presented in section 4. 
Podrobne informacije o opozorilih in previdnostnih ukrepih, povezanih z neželenimi učinki, ki se lahko pojavijo med zdravljenjem s tem zdravilom, so navedene v poglavju 4.
What MEPACT is and what it is used for 
Kaj je zdravilo MEPACT in za kaj ga uporabljamo
MEPACT has not been tested in pregnant women. 
Zdravilo MEPACT ni bilo preizkušeno pri nosečnicah.
It should be administered as adjuvant therapy following resection: twice weekly at least 3 days apart for 12 weeks, followed by once-weekly treatments for an additional 24 weeks for a total of 48 infusions in 36 weeks. 
Uporabljati ga je treba kot adjuvantno zdravljenje po operacijski odstranitvi: dvakrat tedensko z najmanj 3-dnevnim vmesnim presledkom v obdobju 12 tednov, nato pa enkrat tedensko še dodatnih 24 tednov, skupno 48 infuzij v 36 tednih.
However, no specific subset analyses for efficacy are available in patients < 18 years of age and ≥ 18 years of age. 
Vendar pa za bolnike, stare < 18 let in ≥ 18 let, ni na voljo nobenih posebnih analiz učinkovitosti po podskupinah.
If you stop using MEPACT 
Če ste prenehali uporabljati zdravilo MEPACT
It stimulates your immune system to help your body kill tumour cells. 
Zdravilo spodbuja imunski sistem, da le-ta telesu pomaga uničevati tumorske celice.
The schedule of your MEPACT treatments can be adjusted to fit with your chemotherapy schedule. 
Urnik zdravljenja z zdravilom MEPACT se lahko prilagodi vašemu urniku kemoterapije.
In sensitive species (rabbit and dog) the highest daily dose of liposomal mifamurtide that did not cause adverse effects was 0.1 mg/kg, corresponding to 1.2 and 2 mg/m2, respectively. 
Pri občutljivih vrstah (kuncih in psih) je največji dnevni odmerek liposomskega mifamurtida, ki ni povzročil neželenih učinkov, znašal 0,1 mg/kg, kar ustreza 1,2 oz. 2 mg/m2.
Takeda France SAS Immeuble Pacific 11-13 Cours Valmy 92800 - Puteaux France 
Takeda France SAS Immeuble Pacific 11-13 Cours Valmy 92800 - Puteaux Francija
Mifamurtide treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of osteosarcoma. 
Zdravljenje z mifamurtidom morajo uvesti in nadzorovati zdravniki specialisti, ki imajo izkušnje z diagnosticiranjem in zdravljenjem osteosarkoma.
It can also be administered as an outpatient. 
Prejemate ga lahko tudi kot ambulantni bolnik.
The mean area under the curve (AUC) was 17.0 ± 4.86 h x nM and Cmax (maximum concentration) was 15.7 ± 3.72 nM. 
Povprečna površina pod krivuljo (AUC) je bila 17,0 ± 4,86 h x nM, vrednost Cmax (največja koncentracija) pa 15,7 ± 3,72 nM.
It may be difficult to distinguish allergic reactions from exaggerated inflammatory responses, but patients should be monitored for signs of allergic reactions. 
Med alergijskimi reakcijami in povečanimi vnetnimi odzivi je težko razlikovati, vendar pa je treba bolnike nadzirati glede pojava znakov alergijskih reakcij.
MEPACT is used to treat osteosarcoma (bone cancer) in children, adolescents and young adults (between 2 and 30 years). 
Zdravilo MEPACT uporabljamo za zdravljenje osteosarkoma (kostnega raka) pri otrocih, mladostnikih in mladih odraslih (starih od 2 leti do 30 let).
MEPACT contains the active substance mifamurtide, similar to a component of the cell wall of certain bacteria. 
Zdravilo MEPACT vsebuje učinkovino mifamurtid, ki je podobna sestavini celične stene nekaterih bakterij.
Dehydration, Hypokalaemia, Decreased appetite 
Dehidracija, Hipokaliemija, Zmanjšan apetit
Other medicines and MEPACT 
Druga zdravila in zdravilo MEPACT
MTP-PE is a specific ligand of NOD2, a receptor found primarily on monocytes, dendritic cells and macrophages. 
MTP-PE je specifičen ligand NOD2, receptorja, ki ga najdemo predvsem na monocitih, dendritičnih celicah in makrofagih.
- corticosteroids, used to treat inflammations, allergies or asthma. 
- kortikosteroide, ki se uporabljajo za zdravljenje vnetij, alergij ali astme.
Materials required but not provided: 
Potrebni materiali, ki niso priloženi:
Cyanosis, Palpitations 
Cianoza, Palpitacije
The filter and syringe must not be removed from the vial. 
Filtra in brizge ne smete odstraniti iz viale.
Although these studies are not conclusive, there is no evidence of interference of mifamurtide with the anti-tumour effects of chemotherapy and vice versa. 
Te študije sicer ne dajejo dokončnega odgovora, vendar pa ni dokazov, da bi mifamurtid vplival na protitumorske učinke kemoterapije in obratno.
MTP-PE is a potent activator of monocytes and macrophages. 
MTP-PE je močan aktivator monocitov in makrofagov.
The exact mechanism by which mifamurtide activation of monocytes and macrophages leads to anti-tumour activity in animals and humans is not yet known. 
Natančen mehanizem, s katerim mifamurtid aktivira monocite in makrofage, kar vodi v protitumorno aktivnost pri živalih in ljudeh, še ni znan.
Do not refrigerate or freeze the solution. 
Suspenzije ne shranjujte v hladilniku in je ne zamrzujte.
If a severe respiratory reaction occurs, administration of mifamurtide should be discontinued and appropriate treatment initiated. 
Če pride do hude respiratorne reakcije, je treba uporabo mifamurtida prekiniti in uvesti ustrezno zdravljenje.
Although hearing loss may be attributable to ototoxic chemotherapy, like cisplatin, it is unclear whether MEPACT in conjunction with multi-agent chemotherapy may increase hearing loss. 
Čeprav je izgubo sluha mogoče pripisati ototoksični kemoterapiji, kot je cisplatin, ni jasno, ali lahko zdravilo MEPACT skupaj s polikemoterapijo poveča izgubo sluha.
Instructions for preparation of MEPACT for intravenous infusion 
Navodila za pripravo zdravila MEPACT za intravensko infundiranje
It will be given to you twice a week (at least three days apart) for the first 12 weeks, then once a week for 24 more weeks. 
V prvih 12 tednih zdravljenja ga boste prejeli dvakrat na teden (z vsaj tridnevnim vmesnim presledkom), v nadaljnjih 24 tednih zdravljenja pa enkrat na teden.
It is not necessary to interrupt your schedule of MEPACT if your chemotherapy is delayed; you should complete 36 weeks (9 months) of treatment with MEPACT without an interruption. 
Urnika zdravljenja z zdravilom MEPACT ni treba spreminjati, če se vaša kemoterapija prestavi Zdravljenje z zdravilom MEPACT je treba zaključiti v 36 tednih (9 mesecih) brez prekinitve.
The safety of liposomal mifamurtide has been assessed in more than 700 patients with various kinds and stages of cancer and in 21 healthy adult subjects (see section 4.8). 
Varnost liposomskega mifamurtida je bila ocenjena pri več kot 700 bolnikih z različnimi vrstami raka v različnih stadijih ter pri 21 zdravih odraslih preiskovancih (glejte poglavje 4.8).
Chemical and physical stability has been demonstrated for 6 hours up to 25 ºC. 
Ugotovljena je bila kemijska in fizikalna stabilnost 6 ur pri temperaturi do 25 ºC.
Contact your doctor immediately: - if you have continuing fever or chills more than 8 hours after your dose of MEPACT, 
Zdravnika takoj obvestite: - če imate zvišano telesno temperaturo ali mrzlico neprekinjeno več kot 8 ur po odmerku zdravila
MEPACT will be administered only under the supervision of a specialist physician. 
Zdravilo MEPACT boste prejeli pod nadzorom zdravnika specialista.
On the basis of the scientific conclusions for mifamurtide the CHMP is of the opinion that the benefit-risk balance of the medicinal product(s) containing mifamurtide is unchanged subject to the proposed changes to the product information. 
Na podlagi znanstvenih zaključkov za mifamurtid odbor CHMP meni, da je razmerje med koristjo in tveganjem zdravil(-a), ki vsebuje(-jo) mifamurtid nespremenjeno ob upoštevanju predlaganih sprememb v informacijah o zdravilu.
These data indicate that neither total nor free mifamurtide accumulated during the treatment period. 
Ti podatki kažejo, da se med zdravljenjem ni kopičil ne skupni ne prosti mifamurtid.
• 1 vial of MEPACT (mifamurtide) 
• 1 viala zdravila MEPACT (mifamurtid)
if you have a history of inflammatory or autoimmune disease or have been treated with corticosteroids or other medicines that may affect your immune system. 
- če imate ali ste kdaj imeli vnetno ali avtoimunsko bolezen ali ste se zdravili s kortikosteroidi ali z drugimi zdravili, ki lahko vplivajo na imunski sistem.
A fever with a low white blood cell count (neutropenia) may be a sign of serious infection. 
Zvišana telesna temperatura ob sočasnem zmanjšanju števila belih krvnih celic (nevtropeniji) je lahko znak resne okužbe.
Fever or chills persisting for more than 8 hours after administration of mifamurtide should be evaluated for possible sepsis. 
Pri zvišanju telesne temperature ali mrzlici, ki traja več kot 8 ur po uporabi mifamurtida, je treba presoditi, če gre za možno sepso.
Store in a refrigerator (2 C-8 C). 
Shranjujte v hladilniku (2 C - 8 C).
if you have any allergic reactions to any medicines such as rash, breathlessness and high blood pressure. 
- če imate kakršno koli alergijsko reakcijo na katero koli zdravilo, kot so izpuščaj, težko dihanje in visok krvni tlak.
The majority of patients experience chills, fever and fatigue especially during the first administration of MEPACT. 
Pri večini bolnikov se je pojavila mrzlica, zvišana telesna temperatura in utrujenost, še posebej pri prvi uporabi zdravila MEPACT.
Two patients with pre-existing asthma developed mild to moderate respiratory distress associated with the treatment (see section 4.8). 
Pri dveh bolnikih s predhodno obstoječo astmo se je pojavila blaga do zmerna dihalna stiska, povezana z zdravljenjem (glejte poglavje 4.8).
Regular use of corticosteroids should be avoided when using MEPACT as this may affect the way the medicine works. 
Med zdravljenjem z zdravilom MEPACT se morate izogibati redni uporabi kortikosteroidov, saj ta lahko vpliva na delovanje zdravila.
The liposomal suspension is infused intravenously over about 1 hour. 
Intravensko infundiranje liposomske suspenzije traja približno 1 uro.
abdomen, arm or leg - cough, trouble breathing or rapid breathing - low body temperature - low number of red blood cells 
prsnem košu, trebuhu, rokah ali nogah - kašelj, oteženo dihanje ali hitro dihanje - nizka telesna temperatura - majhno število rdečih krvnih celic
In a separate study in 14 patients, mean serum concentration-time curves of total and free mifamurtide that were assessed after the first infusion of mifamurtide and after a last infusion 11 or 12 weeks later, were almost superimposable and the mean AUC values of the free mifamurtide after the first and last infusion were similar. 
V ločeni študiji, v kateri je sodelovalo 14 bolnikov, so se povprečne krivulje koncentracije skupnega in prostega mifamurtida v serumu v odvisnosti od časa, ki so bile ocenjene po prvi infuziji mifamurtida in po zadnji infuziji 11 ali 12 tednov kasneje, skoraj pokrivale, povprečne vrednosti AUC prostega mifamurtida po prvi in zadnji infuziji pa so bile podobne.
Mifamurtide (muramyl tripeptide phosphatidyl ethanolamine, MTP-PE) is a fully synthetic derivative of muramyl dipeptide (MDP), the smallest naturally-occurring immune stimulatory component of cell walls from Mycobacterium sp. 
Mifamurtid (muramil tripeptid fosfatidil etanolamin, MTP-PE) je povsem sintetičen derivat muramil dipeptida (MDP), najmanjše naravno prisotne sestavine celičnih sten Mycobacterium sp., ki stimulira imunost.
What you need to know before you use MEPACT 
Kaj morate vedeti, preden boste uporabili zdravilo MEPACT
If symptoms are persistent and worsening, administration should be delayed or discontinued. 
Če simptomi ne izginejo in se poslabšajo, je treba uporabo zdravila preložiti ali prekiniti.
A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy should be made taking into account the benefit of breast-feeding to the child and the benefit of mifamurtide therapy to the woman. 
Odločiti se je treba med prenehanjem dojenja in prenehanjem/prekinitvijo zdravljenja z mifamurtidom, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja za mater.
It is used after you have had surgery to remove the tumour and together with chemotherapy to kill remaining cancer cells to reduce the risk of cancer coming back. 
Zdravilo uporabljamo po kirurški odstranitvi tumorja skupaj s kemoterapijo za uničevanje preostalih rakastih celic, da se zmanjša tveganje za ponovitev raka.