natgillin/translations-raw huggingface dataset:
Thrombocytopenia and anaemia occur less often and are seldom seen without a preceding leukopenia. 
Trombocitopenija in anemija se pojavita manj pogosto in sta redko opaženi brez predhodne levkopenije.
OTHER SPECIAL WARNING(S), IF NECESSARY Cytotoxic: Handle with caution. 
DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA Citotoksično: ravnajte previdno.
It is important that you use the correct dosing syringe for your medicine. 
Pomembno je, da za zdravilo uporabite pravilno brizgo za odmerjanje.
- antiretroviral medicines (those that inhibit or destroy a retrovirus such as HIV), e.g. didanosine, 
- protiretrovirusna zdravila (ki zavirajo ali uničujejo retroviruse, kot je HIV), npr. didanozin,
Severe hepatic impairment (Child-Pugh classification C). 
Huda jetrna okvara (stopnje C po Child-Pughovi klasifikaciji).
The posology should be based on the patient's body weight (kg). 
Odmerjanje je treba določiti na podlagi bolnikove telesne mase (kg).
Although there is no evidence of an age effect on the pharmacokinetic-pharmacodynamic relationship, elderly patients may be more sensitive to the effects of hydroxycarbamide and therefore consideration should be given to starting with a lower initial dose and more cautious dose escalation. 
Čeprav ni dokazov o vplivu starosti na farmakokinetično-farmakodinamično razmerje, so lahko starejši bolniki občutljivejši za učinke hidroksikarbamida, zato je treba premisliti o uvedbi nižjega začetnega odmerka in previdnejšem stopnjevanju odmerka.
Spillages must be wiped immediately. 
Razlito zdravilo je treba takoj pobrisati.
Live vaccines are not recommended in immunosuppressed patients. 
Živa cepiva niso priporočljiva za imunsko ogrožene bolnike.
Some cells become abnormal, rigid and take a crescent or sickle shape which leads to anaemia. 
Nekatere celice postanejo nenormalne, toge in dobijo obliko polmeseca ali srpa, kar povzroči anemijo.
Erythrocytic abnormalities; megaloblastic erythropoiesis, which is selflimiting, is often seen early in the course of hydroxycarbamide therapy. 
Nepravilnosti eritrocitov; megaloblastna eritropoeza, ki je samoomejujoča, se pogosto opazi zgodaj med zdravljenjem s hidroksikarbamidom.
The patient should be instructed to immediately contact a doctor in case of suspected pregnancy. 
Bolniku oziroma bolnici je treba naročiti, naj v primeru suma na nosečnost o tem nemudoma obvesti zdravnika.
For male patients taking Xromi, if your partner becomes pregnant or plans to become pregnant, your doctor will discuss with you the potential benefits and risks of continuing using Xromi. 
Velja za moške bolnike, ki jemljejo zdravilo Xromi: če partnerica zanosi ali načrtuje nosečnost, se bo zdravnik z vami pogovoril o možnih koristih in tveganjih nadaljevanja zdravljenja z zdravilom Xromi.
This study used a non-inferiority trial design with a primary endpoint of TCD velocity at 24 months, controlling for baseline (enrollment) values. 
V tej študiji je bilo uporabljeno preskušanje neinferiornosti s primarno končno točko hitrosti TCD pri 24 mesecih, pri čemer so se preverjale osnovne (vhodne) vrednosti.
However, a lack of increase in MCV, HbF, or both, is not an indication to discontinue therapy if the patient responds clinically (e.g. decreased incidence of pain or hospitalisation). 
Če se MCV in/ali HbF ne povečata, to ni znak za prekinitev zdravljenja, če se bolnik klinično odziva (npr. manjša pogostnost bolečine ali manj hospitalizacij).
- Depending on these results your doctor may change your dose of Xromi. 
- Zdravnik bo glede na te rezultate morda spremenil vaš odmerek zdravila Xromi.
Prior to launch of Xromi in each Member State the Marketing Authorisation Holder (MAH) must agree about the content and format of the educational programme, including communication media, distribution modalities, and any other aspects of the programme, with the National Competent Authority. 
Pred prihodom zdravila Xromi na trg v posamezni državi članici se mora imetnik dovoljenja za promet z zdravilom s pristojnim nacionalnim organom dogovoriti glede vsebine in oblike izobraževalnega programa, vključno s sredstvi obveščanja, načini razdeljevanja in vsemi drugimi vidiki programa.
The educational programme is aimed to ensure the safe and effective use of the product, to minimise the risks listed below and to reduce the burden of adverse reactions with Xromi. 
Namen izobraževalnega programa je zagotoviti varno in učinkovito uporabo zdravila ter zmanjšati spodaj našteta tveganja in breme neželenih učinkov zdravila Xromi.
Remove the bottle cap (figure 1) and push the adaptor firmly into the top of the bottle and leave in place for future doses (figure 2). 
Odstranite pokrovček steklenice (slika 1) in nastavek močno potisnite na vrh steklenice ter ga pustite nameščenega za naslednje odmerke (slika 2).
In adults without swallowing difficulties, solid oral formulations may be more appropriate and convenient. 
Za odrasle osebe brez težav pri požiranju so lahko primernejše in priročnejše trdne peroralne oblike zdravila.
Dose was reduced by 50% for bone marrow toxicity. 
Odmerek se je v primeru toksičnosti za kostni mozeg zmanjšal za 50 %.
Number of events / patient/ year 
Število primerov/bolnikov/le to
Hold the syringe under water and move the plunger up and down several times to make sure the inside of the syringe is clean. 
Brizgo držite pod vodo ter bat večkrat premaknite gor in dol, da bo notranjost brizge čista.
The patient information pack should contain: 
Paket gradiva z informacijami za bolnika mora vsebovati:
In adults, the urinary recovery of unchanged drug is reported to be approximately 37% of the oral dose when renal function is normal. 
Pri odraslih so poročali, da izmerjeno nespremenjeno zdravilo v urinu znaša približno 37 % peroralnega odmerka, če ledvice normalno delujejo.
The list is presented by system organ class, MedDRA preferred term, and frequency using the following frequency categories: very common (≥ 1/10), common (≥ 1/100, < 1/10), uncommon (≥ 
Seznam je razčlenjen glede na organski sistem, imena, ki jih predpisuje MedDRA, in pogostnost, pri čemer so bile uporabljene naslednje pogostnosti: zelo pogosti (≥ 1/10), pogosti (≥ 1/100, < 1/10),
Very common: may affect more than 1 in 10 people - Absence or low amount of sperm in the semen (azoospermia or oligospermia). 
Zelo pogosti: pojavijo se lahko pri več kot 1 od 10 bolnikov - odsotnost ali nizka količina semenčic v spermi (azoospermija ali oligospermija)
Xromi may be taken with or after meals at any time of the day but patients should standardise the method of administration and time of day. 
Bolnik lahko vzame zdravilo Xromi med obrokom ali po njem v katerem koli delu dneva, vendar mora standardizirati način dajanja in čas jemanja zdravila.
You may be more sensitive to the effects of Xromi and your doctor may need to give you a lower dose. 
Morda ste bolj občutljivejši za učinke zdravila Xromi, zato vam bo zdravnik morda moral predpisati nižji odmerek.
Low fixed dose hydroxycarbamide in children with Sickle Cell Disease (Jain et al 2012) 
Nizek fiksni odmerek hidroksikarbamida pri otrocih s srpastoceličnim sindromom (Jain et al 2012)
The MAH shall ensure that in each Member State where Xromi is marketed, all healthcare professionals and patients/carers who are expected to prescribe and use Xromi have access to/are provided with the following educational package to be disseminated through professional bodies: 
Imetnik dovoljenja za promet z zdravilom zagotovi, da bodo v vsaki državi članici, kjer se zdravilo Xromi trži, vsi zdravstveni delavci in bolniki/skrbniki, za katere se pričakuje, da bodo predpisovali in uporabljali zdravilo Xromi, imeli dostop ali prejeli naslednji paket izobraževalnega gradiva, ki ga bodo razdeljevali strokovni organi:
B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (See Annex I: Summary of Product Characteristics, section 4.2). 
B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE Predpisovanje in izdaja zdravila je le na recept s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
Wash the syringe with cold or warm tap water and rinse well. 
Brizgo umijte s hladno ali toplo vodo iz pipe in jo dobro splaknite.
If the solution comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water (see section 6.6). 
Če raztopina pride v stik s kožo ali sluznico, jo takoj in temeljito umijte z milom in vodo (glejte poglavje 6.6).
In children, the fraction of hydroxycarbamide excreted unchanged into the urine comprised about 50%. 
Pri otrocih je delež nespremenjenega hidroksikarbamida, ki se je izločil v urin, znašal približno 50 %.
The largest difference in the pharmacokinetic profile was a trend towards a shorter time to peak concentration following ingestion of the liquid compared with the capsule, but that difference did not reach statistical significance (0.74 versus 0.97 hours, p = 0.14). 
Največja razlika v farmakokinetičnem profilu je bil trend v smeri krajšega časa, v katerem se najvišja koncentracija doseže po zaužitju tekočine, v primerjavi s časom po zaužitju kapsule, vendar ta razlika ni bila statistično pomembna (0,74 proti 0,97 ure, p = 0,14).
There are no data that support specific dose adjustments in patients with hepatic impairment. 
Ni podatkov, ki bi podpirali posebno prilagajanje odmerka pri bolnikih z jetrno okvaro.
A total of 299 participants were randomised; 152 to hydroxycarbamide and 147 to matching placebo. 
299 udeležencev; 152 jih je prejemalo hidroksikarbamid in 147 ujemajoči se placebo.
Severe renal impairment (CrCl < 30 ml/min). 
Huda ledvična okvara (CrCl < 30 ml/min).
The maximum dose is 35 mg/kg/day. 
Največji dnevni odmerek je 35 mg/kg.
Leukaemia, skin cancers (in elderly patients) 
neznana levkemija, kožni rak (pri starejših bolnikih)
Immediate treatment consists of gastric lavage, followed by supportive therapy for the cardiorespiratory systems if required. 
Takojšne zdravljenje obsega gastrično lavažo, ki ji po potrebi sledi podporna terapija za kardiorespiratorni sistem.
Xromi should only be given to you by a specialist doctor who is experienced in treating blood problems. 
Zdravilo Xromi vam lahko predpiše samo zdravnik specialist, ki ima izkušnje z zdravljenjem težav s krvjo.
In adult cancer patients, hydroxycarbamide was eliminated with a half-life of approximately 2-3 hours. 
Pri odraslih bolnikih z rakom se je hidroksikarbamid izločil z razpolovnim časom približno 2-3 ure.
Take the medicine pack and this leaflet with you. 
S seboj vzemite pakiranje zdravila in ta navodila za uporabo.
Rarely leg ulcers and very rarely systemic lupus erythematosus have been reported. 
Redko so poročali o ulkusih na nogah, zelo redko pa o sistemskem eritematoznem lupusu.
Hydroxycarbamide is unequivocally genotoxic and although conventional long-term carcinogenicity studies have not been conducted, hydroxycarbamide is presumed to be a transspecies carcinogen which implies a carcinogenic risk to humans. 
Hidroksikarbamid je nedvoumno genotoksičen, in čeprav konvencionalne dolgoročne študije karcinogenosti niso bile izvedene, domnevajo, da je karcinogen za različne vrste, kar nakazuje na karcinogeno tveganje za človeka.
• Physician educational material 
• izobraževalno gradivo za zdravnike,
This possibility should be carefully considered before administering this medicinal product to male or female patients who may contemplate conception. 
O tej možnosti je treba temeljito premisliti, preden se to zdravilo daje bolnikom in bolnicam, ki razmišljajo o spočetju otroka.
The study reported 16 patients out of 22 (73%) did not require any hospitalisation for painful episodes when treated with hydroxycarbamide as compared with only 3 of 22 (14%) when treated with placebo. 
Študija je pokazala, da 16 od 22 bolnikov (73 %) med zdravljenjem s hidroksikarbamidom ni potrebovalo nobene hospitalizacije zaradi bolečinskih epizod, medtem ko v skupini, ki se je zdravila s placebom, hospitalizacije niso potrebovali le 3 od 22 bolnikov (14 %).
Xromi will decrease the number of painful crises as well as the need for hospitalisation as a result of the disease. 
Zdravilo zmanjša število bolečih kriz in potrebo po hospitalizaciji zaradi bolezni.
In the event of bone marrow suppression, haematological recovery usually occurs within two weeks of withdrawal of hydroxycarbamide. 
V primeru supresije kostnega mozga pride do hematološkega okrevanja običajno v dveh tednih od prekinitve jemanja hidroksikarbamida.
Very common reversible oligo- and azoo-spermia have been observed in man, although these disorders are also associated with the underlying disease. 
Pri ljudeh so opazili zelo pogoste reverzibilne primere oligospermije in azoospermije, čeprav sta ti bolezni povezani tudi z osnovno boleznijo.
The sickle cells also get stuck in blood vessels, blocking blood flow. 
Srpaste celice se lahko tudi zataknejo v krvnih žilah in ovirajo pretok krvi.
What Xromi is and what it is used for What you need to know before you take Xromi How to take Xromi 
Kaj je zdravilo Xromi in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Xromi Kako jemati zdravilo Xromi
Syringes should be rinsed and washed with cold or warm water and dried completely before the next use. 
Brizgi je treba pred naslednjo uporabo splakniti in umiti s hladno ali toplo vodo ter posušiti do suhega.
If you have kidney disease 
Če imate ledvično okvaro
The estimated volume of distribution of hydroxycarbamide approximates total body water. 
Ocenjeni volumen porazdelitve hidroksikarbamida je približno enak celotni količini vode v telesu.
Rare: may affect up to 1 in 1000 people 
Redki: pojavijo se lahko pri največ 1 od 1.000 bolnikov
In a single dose study in children with Sickle Cell Disease, the mean half-life was reported to be 1.7 hours. 
V študiji enkratnega odmerka pri otrocih s srpastoceličnim sindromom so poročali o povprečnem razpolovnem času 1,7 ure.
Pharmacotherapeutic group: Antineoplastic agents, other antineoplastic agents, ATC code: L01XX05. 
Farmakoterapevtska skupina: zdravila z delovanjem na novotvorbe, druga zdravila z delovanjem na novotvorbe, oznaka ATC: L01XX05.
Repeat the above for each dose as instructed by your doctor or pharmacist. 
Za vsak odmerek ponovite zgoraj opisani postopek, kot vam je naročil zdravnik ali farmacevt.
Although the mechanism of action has not yet been clearly defined, hydroxycarbamide appears to act by interfering with synthesis of DNA by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or protein. 
Čeprav njegov mehanizem delovanja še ni jasno opredeljen, se predvideva, da deluje tako, da posega v sintezo DNA, ker deluje kot inhibitor ribonukleotid-reduktaze, ne da bi posegal v sintezo ribonukleinske kisline ali beljakovin.
Teratogenic effects manifested as partially ossified cranial bones, absence of eye sockets, hydrocephaly, bipartite sternebrae, and missing lumbar vertebrae. 
Teratogeni učinki so se izražali kot delno osificirane lobanjske kosti, odsotnost očesnih votlin, hidrocefalija, dvodelne sternebrae in manjkajoča ledvena vretenca.
If you get any of the following side effects, talk to your doctor or go to hospital immediately: 
Če opazite katerega koli izmed naslednjih neželenih učinkov, se takoj posvetujte z zdravnikom ali pojdite v bolnišnico:
Other medicines and Xromi 
Druga zdravila in zdravilo Xromi
The macrocytosis may mask the incidental development of folic acid deficiency; regular determinations of serum folic acid are recommended. 
Makrocitoza lahko prikrije naključno pomanjkanje folne kisline; priporočljivo je redno določanje folne kisline v serumu.
Hydroxycarbamide therapy can then be re-initiated at a lower dose (see section 4.2). 
Nato se lahko zdravljenje s hidroksikarbamidom ponovno začne z nižjim odmerkom (glejte poglavje 4.2).
Anyone handling hydroxycarbamide should wash their hands before and after administering a dose. 
Vsak, ki rokuje s hidroksikarbamidom, si mora pred dajanjem odmerka in po njem umiti roke.
In patients with a creatinine clearance (CrCl) ≤ 60 ml/min the initial hydroxycarbamide dose should be decreased by 50%. 
Pri bolnikih z očistkom kreatinina (CrCl) ≤ 60 ml/min je treba začetni odmerek hidroksikarbamida znižati za 50 %.
If you are a parent or care giver administering the medicine, wash your hands before and after administering a dose. 
Če ste starš ali skrbnik, ki daje zdravilo, si pred dajanjem odmerka in po njem umijte roke.
Other known pharmacological effects of hydroxycarbamide which may contribute to its beneficial effects in Sickle Cell Disease include decrease of neutrophils, improved deformability of sickled cells, and altered adhesion of red blood cells to the endothelium. 
Drugi znani farmakološki učinki hidroksikarbamida, ki utegnejo prispevati k njegovim koristnim učinkom pri srpastoceličnem sindromu, so znižanje števila nevtrofilcev, boljša deformabilnost srpastih celic in spremenjena adhezijo rdečih krvničk na endotel.
The volume of distribution following oral dosing of hydroxycarbamide is approximately equal to total body water: adult values of 0.48 - 0.90 L/kg have been reported, whilst in children a population estimate of 0.7 L/kg has been reported. 
Volumen porazdelitve po peroralnem odmerjanju hidroksikarbamida je približno enak celotni količini vode v telesu: pri odraslih so poročali o vrednostih 0,48-0,90 l/kg, pri otrocih pa so poročali o populacijski oceni 0,7 l/kg.
Both male and female patients should be advised to use contraceptive measures before and during treatment with hydroxycarbamide. 
Bolnikom in bolnicam je treba svetovati, naj pred in med zdravljenjem s hidroksikarbamidom uporabljajo kontracepcijo.
Hydroxycarbamide may also delay plasma iron clearance and reduce the rate of iron utilisation by erythrocytes but it does not appear to alter the red blood cell survival time. 
Hidroksikarbamid lahko tudi upočasni plazemski očistek železa in zmanjša stopnjo uporabe železa za nastajanje eritrocitov, vendar se zdi, da ne spremeni časa preživetja rdečih krvničk.
Pregnancy (see section 4.6) 
Nosečnost (glejte poglavje 4.6).
The anaemia commonly observed has mainly been due to an infection with Parvovirus or a splenic sequestration. 
Pogosto opažena anemija je v glavnem posledica okužbe s parvovirusom ali sekvestracije vranice.
HbF interferes with the polymerisation of HbS (sickle haemoglobin) and thus impedes the sickling of red blood cell. 
HbF ovira polimerizacijo HbS (srpastega hemoglobina) in tako preprečuje nastanek srpaste oblike rdeče krvničke.
It is unknown whether this leukaemogenic effect is secondary to hydroxycarbamide or associated with the patient's underlying disease. 
Ni znano, ali je levkemogeni učinek posledica hidroksikarbamida ali pa je povezan z bolnikovo osnovno boleznijo.
If neutropenia or thrombocytopenia occurs, hydroxycarbamide dosing should be temporarily withheld and full blood cell count with white cell differential should be monitored weekly. 
Če se pojavi nevtropenija ali trombocitopenija, je treba odmerjanje hidroksikarbamida začasno prekiniti in tedensko spremljati število vseh krvnih celic,
Toxicology studies have also demonstrated testicular atrophy with decreased spermatogenesis and sperm count in rats and decreased testis weight and reduced sperm counts in mice as well. 
Toksikološke študije so prav tako dokazale atrofijo mod z zmanjšano spermatogenezo in zmanjšanim številom semenčic pri podganah ter zmanjšano maso testisov in zmanjšano število semenčic pri miših.
To decrease the risk of exposure, parents and care givers should wear disposable gloves when handling hydroxycarbamide. 
Za zmanjšanje tveganja izpostavljenosti morajo starši in skrbniki pri rokovanju s hidroksikarbamidom nositi rokavice za enkratno uporabo.
Clear, colourless to pale yellow viscous liquid. 
Bistra, brezbarvna do bledo rumena viskozna tekočina.
The patient's antibody response to vaccines may be decreased. 
Bolnikov odziv protiteles na cepivo je lahko zmanjšan.
The usual starting dose for adults, adolescents and children over the age of 2 years is 15 mg/kg each day and the usual maintenance dose is between 20-25 mg/kg. 
Običajni začetni dnevni odmerek za odrasle, mladostnike in otroke, starejše od 2 let, je 15 mg/kg in običajni vzdrževalni odmerek je 2025 mg/kg.
Patients treated with hydroxycarbamide in combination with didanosine, stavudine, and indinavir showed a median decline in CD4 cells of approximately 100/mm3. 
Pri bolnikih, zdravljenih s hidroksikarbamidom v kombinaciji z didanozinom, stavudinom in indinavirjem, so ugotovili mediano upadanja števila celic CD4 za približno 100/mm3.
Gradual dose titration is recommended to avoid more severe bone marrow suppressions (see section 4.2). 
Priporoča se postopno titriranje odmerka za preprečitev hujše supresije kostnega mozga (glejte poglavje 4.2).
Cutaneous vasculitic toxicities 
Toksični kožni vaskulitisi
Discard 12 weeks after first opening. 
Zavrzite 12 tednov po prvem odprtju.
Patients were randomly assigned to receive either hydroxycarbamide first for 6 months, followed by placebo for 6 months, or placebo first, followed by hydroxycarbamide for 6 months. 
Bolniki so bili naključno razvrščeni in so najprej šest mesecev prejemali hidroksikarbamid in nato še šest mesecev placebo, ali pa so najprej šest mesecev prejemali placebo in nato še šest mesecev hidroksikarbamid.
Hydroxycarbamide affects spermatogenesis, and hence oligospermia and azoospermia are very commonly reported. 
Hidroksikarbamid vpliva na spermatogenezo, zato zelo pogosto poročajo o oligospermiji in azoospermiji.
In patients, whose CrCl was below 60 ml/min or patients with End Stage Renal Disease the mean exposure to hydroxycarbamide was approximately 64% higher than in patients with normal renal function. 
Pri bolnikih, pri katerih je bil CrCl manjši od 60 ml/min, ali bolnikih s končno odpovedjo ledvic je bila povprečna izpostavljenost hidroksikarbamidu za približno 64 % večja kot pri bolnikih z normalnim delovanjem ledvic.
the virus which causes AIDS 
(HIV), povzročitelja aidsa.
While in dogs reversible spermatogenic arrest was noted. 
Pri psih so opazili reverzibilni zastoj spermatogeneze.
Patients should be monitored for vital signs, blood and urine chemistry, renal and hepatic function and full blood counts for at least 3 weeks. 
Vsaj tri tedne je treba nadzirati bolnikove vitalne funkcije, kemično sestavo krvi in urina, delovanje ledvic in jeter ter število vseh krvnih celic.
Close monitoring of blood parameters is advised (see section 4.2). 
Priporoča se natančno spremljanje krvnih parametrov (glejte poglavje 4.2).
If you forget to take Xromi Tell your doctor. 
Če ste pozabili vzeti zdravilo Xromi O tem obvestite zdravnika.
Hydroxycarbamide treatment should be supervised by a physician or other healthcare professionals experienced in the management of patients with Sickle Cell Disease. 
Zdravljenje s hidroksikarbamidom mora nadzirati zdravnik ali drug zdravstveni delavec, izkušen v obravnavanju bolnikov s srpastoceličnim sindromom.
Other commonly reported adverse effects also include nausea, constipation, headache, and dizziness. 
Drugi pogosti neželeni učinki vključujejo tudi navzeo, zaprtost, glavobol in omotico.
The morphologic change resembles pernicious anaemia, but is not related to vitamin B12 or folic acid deficiency. 
Morfološka sprememba je podobna perniciozni anemiji, vendar ni povezana s pomanjkanjem vitamina B12 ali folne kisline.
Bone marrow depression is more likely in patients who have previously received radiotherapy or cytotoxic cancer chemotherapeutic medicinal products; hydroxycarbamide should be used cautiously in such patients. 
Depresija kostnega mozga je pogostejša pri bolnikih, ki so predhodno prejemali radioterapijo ali citotoksična kemoterapevtska zdravila za zdravljenje raka; pri teh bolnikih je treba hidroksikarbamid uporabljati previdno.
Male patients should be informed by their healthcare professionals about the possibility of sperm conservation (cryopreservation) before the start of therapy. 
Zdravstveni delavci morajo bolnike pred začetkom terapije obvestiti o možnosti shranjevanja sperme