natgillin/translations-raw huggingface dataset:
Do not take Jentadueto if any of the above applies to you. 
Če imate karkoli od naštetega, ne vzemite zdravila Jentadueto.
Number of Subjects 
DRUGI PODATKI
Pancreatitis rare # 
Bulozni pemfigoid
Daily 
občasno
Severe infections may lead to kidney problems, which can put you at risk for lactic acidosis (see 'Warnings and precautions'). 
Hude okužbe lahko privedejo do težav z ledvicami, kar lahko predstavlja tveganje za nastanek laktacidoze (glejte 'Opozorila in previdnostni ukrepi'); - če ste izgubili veliko vode (dehidracija), npr. zaradi dolgotrajne ali hude driske ali večkratnega zaporednega bruhanja.
common 
pogosti
Body Mass Index (BMI) 
Indeks telesne mase
No teratogenic effects were observed in rabbits at > 1,000 times human exposure. 
Pri kuncih preko 1.000-krat večja izpostavljenost kot za človeka ni bila povezana s teratogenimi učinki.
Liver, kidneys, stomach, reproductive organs, thymus, spleen, and lymph nodes were target organs of toxicity in Cynomolgus monkeys at more than 450 times human exposure. 
Pri opicah vrste Cynomolgus so se pri izpostavljenosti, ki je bila preko 450-krat večja kot pri človeku, pokazali kot tarčni organi za toksične učinke: jetra, ledvice, želodec, reproduktivni organi, timus, vranica in limfni vozli.
Combination requiring precautions for use 
B. NAVODILO ZA UPORABO
Invented name Strength Pharmaceutical Form Route of Administration Packaging 
Izmišljeno ime jakost farmacevtska oblika pot uporabe ovojnina velikost pakiranja
14 October 2016 EMA/610687/2016 EMEA/H/C/004080 
14. oktober 2016 EMA/610687/2016 EMEA/H/C/004080
The company had not yet responded to the questions at the time of the withdrawal. 
Družba v času umika še ni odgovorila na zastavljena vprašanja.
The application was withdrawn after the CHMP had evaluated the initial documentation provided by the company and formulated a list of questions. 
Vlogo so umaknili po tem, ko je CHMP ocenil začetno dokumentacijo, ki jo je predložila družba, in oblikoval seznam vprašanj.
This upsets the essential functions that keep the cells alive, and kills the bacteria. 
S tem ovira funkcije, ki so bistvenega pomena za preživetje teh celic, kar posledično uniči bakterije.
• gynaecological infections; 
• ginekoloških okužb;
• community-acquired pneumonia (infection of the lungs caught away from hospital); 
• zunajbolnišnične pljučnice (okužbe pljuč, s katero se bolnik okuži zunaj bolnišnice);
Because Ertapenem Hospira was developed as a generic medicine, the company presented the results of studies to show the quality of the medicine. 
Ker je bilo zdravilo Ertapenem Hospira razvito kot generično zdravilo, je družba predstavila rezultate študij, ki dokazujejo kakovost zdravila.
It was to be available as a vial containing a powder which is dissolved before use to make up a solution for infusion (drip) into a vein. 
Na voljo naj bi bilo v obliki vial s praškom, ki se pred uporabo raztopi za pripravo raztopine za infundiranje (kapalne infuzije) v veno.
The CHMP had concerns about the choice of the starting materials for making the active substance, the process used to manufacture the medicine, the method for testing the purity of the medicine and the medicine's shelf life. 
Odbor CHMP je imel zadržke glede izbire začetnega materiala za izdelavo zdravilne učinkovine, uporabljenega postopka za izdelavo zdravila, metode preskušanja čistosti zdravila in roka uporabnosti zdravila.
On 13 September 2016, Hospira UK Limited officially notified the Committee for Medicinal Products for Human Use (CHMP) that it wishes to withdraw its application for a marketing authorisation for Ertapenem Hospira, for the treatment of certain infections and for the prevention of infection in colorectal surgery. 
Družba Hospira UK Limited je dne 13. septembra 2016 uradno obvestila Odbor za zdravila za uporabo v humani medicini (CHMP), da želi umakniti vlogo za pridobitev dovoljenja za promet z zdravilom Ertapenem Hospira, namenjenim zdravljenju določenih okužb in preprečevanju okužb pri kolorektalnih kirurških posegih.
Ertapenem attaches to certain proteins on the surface of the bacteria cells. 
Ertapenem se pripoji na določene beljakovine na površini bakterijskih celic.
Ertapenem Hospira was expected to be used in adults and children aged over 3 months to treat the following infections, if caused by bacteria likely to be killed by ertapenem: 
Zdravilo Ertapenem Hospira naj bi se uporabljalo pri odraslih in otrocih, starejših od treh mesecev, za zdravljenje okužb, kadar so te povzročene z bakterijami, ki naj bi jih ertapenem uničil, in sicer naslednjih:
• foot infections in diabetes patients. 
• okužb stopal pri bolnikih s sladkorno boleznijo.
Ertapenem Hospira was also expected to be used to prevent infection at the site of colorectal surgery (surgery in the lower part of the bowel, including the rectum and anus). 
Zdravilo Ertapenem Hospira naj bi se uporabljalo tudi za preprečevanje okužbe na mestu kolorektalnega kirurškega posega (kirurškega posega na spodnjem delu črevesja, vključno z danko in zadnjikom).
At the time of the withdrawal, the CHMP was of the opinion that the company had not addressed its concerns and the quality of Ertapenem Hospira had not been demonstrated. 
Zato je v času umika menil, da družba ni obravnavala izraženih zadržkov in da kakovost zdravila Ertapenem Hospira ni bila dokazana.
Ertapenem can work on a range of different bacteria. 
Ertapenem lahko učinkuje na različne bakterije.
This means that Ertapenem Hospira was intended to be similar to a ‘reference medicine' already authorised in the European Union called Invanz. 
To pomeni, da naj bi bilo zdravilo Ertapenem Hospira podobno „referenčnemu zdravilu“, ki je že odobreno v Evropski uniji (EU), in sicer zdravilu Invanz.
Based on the review of the data, at the time of the withdrawal, the CHMP had some concerns and was of the provisional opinion that Ertapenem Hospira could not have been approved for the treatment of infections and for the prevention of infection in colorectal surgery. 
Na podlagi pregleda podatkov je Odbor v času umika izrazil določene zadržke in je začasno menil, da zdravila Ertapenem Hospira ni mogoče odobriti za zdravljenje okužb in za preprečevanje okužb pri kolorektalnih kirurških posegih.
No further studies were carried out because Ertapenem Hospira is a generic medicine that is given by infusion and contains the same active substance as the reference medicine, Invanz. 
Niso pa bile opravljene nobene dodatne študije, saj je zdravilo Ertapenem Hospira generično zdravilo, ki se daje z infundiranjem in vsebuje enako zdravilno učinkovino kot referenčno zdravilo Invanz.
The active substance in Ertapenem Hospira and Invanz, ertapenem, belongs to a group of antibiotics known as ‘carbapenems'. 
Zdravilna učinkovina v zdravilu Ertapenem Hospira, ertapenem, spada v skupino antibiotikov, imenovano „karbapenemi“.
Ertapenem Hospira was developed as a ‘generic medicine'. 
Zdravilo Ertapenem Hospira je bilo razvito kot „generično zdravilo“.
Ertapenem Hospira is an antibiotic medicine that contains the active substance ertapenem. 
Ertapenem Hospira je antibiotično zdravilo, ki vsebuje zdravilno učinkovino ertapenem.
In its letter notifying the Agency of the withdrawal of the application, the company stated that the withdrawal of the application is based on commercial reasons following an evaluation of the current market situation. 
Družba je v dopisu, s katerim agencijo obvešča o umiku vloge, navedla, da se je za umik vloge za zdravilo Ertapenem Hospira odločila zaradi poslovnih razlogov po ovrednotenju trenutnih razmer na trgu.
Ertapenem Hospira is expected to work in the same way as the reference medicine, Invanz. 
Zdravilo Ertapenem Hospira naj bi delovalo na enak način kot referenčno zdravilo Invanz.
How does Ertapenem Hospira work? 
Kako zdravilo Ertapenem Hospira deluje?
What was Ertapenem Hospira expected to be used for? 
Za kaj naj bi se zdravilo Ertapenem Hospira uporabljalo?
What is Ertapenem Hospira? 
Kaj je zdravilo Ertapenem Hospira?
• infections in the abdomen; 
• trebušnih okužb;
Frequency not known (cannot be estimated from the available data) 
Pogostnost neznana (ni mogoče oceniti iz razpoložljivih podatkov)
The safety database from these studies comprises 923 patients. 
Podatkovna baza o varnosti iz teh študij zajema 923 bolnikov.
- if you have active cancer. 
- če imate aktivnega raka.
• Information on pregnancy prevention. 
• podatke o preprečevanju nosečnosti.
Treatment consists of careful observation and initiation of appropriate supportive measures. 
Zdravljenje je sestavljeno iz skrbnega opazovanja in uvedbe ustreznih podpornih ukrepov.
Avoid touching your nose, eyes, and other parts of the body. 
Ne dotikajte se nosu, oči in drugih delov telesa.
Your doctor may need to supervise you more closely. 
Morda vas bo moral zdravnik bolj skrbno spremljati.
(1) Open the flap on the left end. 
(1) Odprite zavihek na levem koncu.
You can take them with meals or between meals. 
Lahko jih jemljete med obrokom ali med dvema obrokoma.
It is important to talk to your doctor if you think you have an infection. 
Pomembno je, da se posvetujte z zdravnikom, če menite, da imate okužbo.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 22 August 2017 
Datum prve odobritve: 22. avgust 2017
Your doctor will give you guidance on appropriate methods of contraception. 
Zdravnik vam bo dal navodila za ustrezne metode kontracepcije.
Efficacy in patients with high disease activity 
Učinkovitost pri bolnikih z veliko aktivnostjo bolezni
Your doctor will tell you what to do if you have to take these medicines. 
Zdravnik vam bo povedal, kaj morate storiti, če jemljete ta zdravila.
If this is not the case, your treatment will be delayed. 
Če niso, bo zdravljenje preloženo.
For details, see Tables 1 and 2 below. 
Za podrobnosti glejte spodnji preglednici 1 in 2.
The primary objective of this study was safety, while efficacy endpoints were exploratory. 
Primarni cilj te študije je bila varnost, medtem ko so bili opazovani dogodki glede učinkovitosti eksplorativni.
- if you are HIV positive, meaning you are infected with the human immunodeficiency virus (HIV). 
- če ste HIV pozitivni, to pomeni, da ste okuženi z virusom humane imunske pomanjkljivosti (HIV).
Your doctor will decide if you need to stop treatment or not. 
Zdravnik bo odločil, ali morate zdravljenje ustaviti ali ne.
Criteria for initiating and continuing therapy 
Kriteriji za uvedbo in nadaljevanje terapije
Example: if you start your treatment mid April, you take your tablets as shown. 
Primer: če zdravljenje začnete sredi aprila, tablete jemljete, kot je prikazano.
Table 3 Clinical outcomes in the CLARITY study (96 weeks) 
Preglednica 3 Klinični izidi študije CLARITY (96 tednov)
The tablets can be taken independent of food intake. 
Tablete se lahko jemlje neodvisno od vnosa hrane.
There can be overlaps in the effect on your immune system. 
Lahko pride do prekrivanj v učinku na vaš imunski sistem.
Your doctor will decide the best treatment options for you. 
Zdravnik bo odločil o najboljših možnostih zdravljenja za vas.
R-Pharm Germany GmbH Heinrich-Mack-Strasse 35 89257 Illertissen Germany 
R-Pharm Germany GmbH Heinrich-Mack-Strasse 35 89257 Illertissen Nemčija
PML is a serious condition that may lead to severe disability or death. 
PML je resno stanje, ki lahko povzroči hudo prizadetost ali smrt.
This however does not result in any drug accumulation after once daily dosing as this half-life only accounts for a small portion of the AUC. 
Vendar pa to ne povzroči kopičenja zdravila po odmerjanju enkrat na dan, saj predstavlja ta razpolovna doba le majhen delež AUC.
Once you have completed the 2 treatment courses over 2 years, your doctor will continue to monitor your health for another 2 years, in which you do not need to take the medicine. 
Ko boste zaključili 2 ciklusa zdravljenja v 2 letih, bo zdravnik vaše zdravje spremljal še nadaljnji 2 leti, v katerih vam ne bo treba jemati zdravila.
Swallow them without chewing. 
Pogoltnite jih brez žvečenja.
Grade 4 lymphopenia was seen in less than 1% of the patients. 
Limfopenijo 4. stopnje so opazili pri manj kot 1 % bolnikov.
Re-initiation of therapy after year 4 has not been studied. 
Ponovne uvedbe zdravljenja po 4. letu niso preučili.
Fructose intolerance 
Fruktozna intoleranca
When you receive your supply of medicine, check that you have the correct number of tablets. 
Ko boste prejeli zalogo zdravil, preverite, ali imate pravo število tablet.
Oral herpes, dermatomal herpes zoster. 
oralni herpes, dermatomalni herpes zoster
Wash your hands thoroughly with soap and water. 
Roke si temeljito umijte z milom in vodo.
Live or live attenuated vaccines 
Živa ali živa oslabljena cepiva
• 2 and 6 months after start of treatment in each treatment year. 
• 2 in 6 mesecev po začetku zdravljenja v vsakem letu zdravljenja.
Concomitant treatment is not recommended. 
Sočasno zdravljenje ni priporočljivo.
Take the tablet(s) at about the same time each day. 
Tableto(i) vzemite vsak dan ob približno istem času.
Example: if you weigh 85 kg and are about to start treatment week 1, you will be given 8 tablets. 
Primer: če tehtate 85 kg in boste začeli s 1. tednom zdravljenja, boste dobili 8 tablet.
- certain types of vaccines (live and live attenuated vaccines). 
- nekaterimi vrstami cepiv (na primer živa ali živa oslabljena cepiva).
If your daily dose is 2 tablets, take them at the same time. 
Če sta vaš dnevni odmerek 2 tableti, ju vzemite istočasno.
Push the tray back into the carton. 
Nosilec potisnite nazaj v škatlo.
Infection with human immunodeficiency virus (HIV). 
Okužba z virusom humane imunske pomanjkljivosti (HIV).
- if you are pregnant or breast-feeding (see also 'Pregnancy and breast-feeding'). 
- če ste noseči ali dojite (glejte tudi 'Nosečnost in dojenje').
If you miss a dose and do not remember it until the following day 
Če izpustite odmerek in se tega ne spomnite do naslednjega dne
1 tablet 4 tablets 5 tablets 6 tablets 7 tablets 8 tablets 
1 tableta 4 tablete 5 tablet 6 tablet 7 tablet 8 tablet
Push (text to indicate the two hooks that have to be pressed for opening) QR code to be included www.mavenclad-instructions.com 
Pritisnite (besedilo, ki označuje dva zatiča, ki ju je treba pritisniti, da se nosilec odpre) Vključi se koda QR www.mavenclad-instructions.com
• Additional risk minimisation measures 
• • Dodatni ukrepi za zmanjševanje tveganj
Harderian gland tumours are not considered to be of clinical relevance, as humans do not have comparable anatomical structures. 
Tumorji Harderjeve žleze ne veljajo za klinično pomembne, saj ljudje nimajo primerljivih anatomskih struktur.
An effect on disability progression could not be shown in either subgroup. 
Učinka na napredovanje prizadetosti ni bilo možno prikazati v nobeni podskupini.
You will need to wait between 4 and 6 weeks for the vaccination to take effect. 
Morali boste počakati od 4 do 6 tednov, da bo cepivo začelo učinkovati.
OTHER SPECIAL WARNING, IF NECESSARY Cytotoxic: Handle with caution. 
DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA Citotoksično: ravnajte previdno.
Contact with skin should be limited. 
Stik s kožo morate omejiti.
Talk to your doctor if you have previously had cancer. 
Povejte zdravniku, če ste imeli raka.
Use of MAVENCLAD is not recommended in patients below the age of 18 years, because it has not been investigated in this age group. 
Uporaba zdravila MAVENCLAD se ne priporoča pri bolnikih, mlajših od 18 let, ker v tej starostni skupini ni bila raziskana.
• Guidance for patient's monitoring during the treatment; 
• vodnik za spremljanje bolnika med zdravljenjem;
- if you have moderate or severe kidney problems. 
- če imate zmerne ali hude težave z ledvicami.
MS is a disease in which inflammation destroys the protective sheath around the nerves. 
MS je bolezen, pri kateri vnetje uniči zaščitni ovoj okoli živcev.
• patients with 2 or more relapses in the previous year, whether on DMD treatment or not. 
• bolnike z 2 recidivoma ali več v preteklem letu, bodisi zdravljenih z DMD ali ne.
How to take your medicine 
Kako jemati to zdravilo
The estimated terminal half-life for a typical patient from the population pharmacokinetic analysis is approximately 1 day. 
Ocenjena končna razpolovna doba za običajnega bolnika iz populacijske farmakokinetične analize je približno 1 dan.
Have a glass of water ready and make sure your hands are clean and dry before taking the tablet(s). 
Pripravite kozarec vode in se prepričajte, da imate čiste in suhe roke, preden vzamete tableto(-i).
Consultation with a haematologist is advised. 
Priporočljivo se je posvetovati s hematologom.
Patients with hereditary problems of fructose intolerance should not take this medicinal product. 
Bolniki z dedno intoleranco za fruktozo ne smejo jemati tega zdravila.
500 cells/mm³, it should be actively monitored until values increase again. 
500 celic/mm³, je treba število limfocitov aktivno spremljati, dokler vrednost znova ne zraste.
Careful monitoring of haematological parameters is recommended in such cases. 
V teh primerih se priporoča skrbno nadziranje hematoloških parametrov.
(3) Pull the tray out until it stops. 
(3) Izvlecite nosilec, dokler se ne zaustavi.
Very rare side effect - may affect up to 1 in 10,000 people - tuberculosis 
Zelo redki neželeni učinki - pojavijo se lahko pri največ 1 od 10.000 bolnikov - tuberkuloza
If such signs and symptoms occur, antiinfective treatment should be initiated as clinically indicated. 
Če se pojavijo takšni znaki in simptomi, je treba uvesti zdravljenje okužbe glede na klinično indikacijo.
Make sure you know how many tablets are contained in the package. 
Prepričajte se, da veste, koliko tablet vsebuje pakiranje.
Patients were required to have at least 1 relapse in the previous 12 months. 
Bolniki so morali imeti vsaj 1 recidiv v zadnjih 12 mesecih.
If you have taken more tablets than you should, contact your doctor immediately. 
Če ste vzeli več tablet kot bi smeli, takoj obvestite zdravnika.
Effects on the kidneys were also seen in mice. 
Učinke na ledvice so opazili tudi pri miših.
Example: if you have to take 8 tablets, you would take 2 tablets on Day 1, Day 2, Day 3, then 1 tablet on Day 4 and Day 5. 
Primer: če morate vzeti 8 tablet, bi vzeli 2 tableti 1. dan, 2. dan, 3. dan, in nato 1 tableto 4. dan in 5. dan.
Rash, alopecia. 
izpuščaj, alopecija
Clinically relevant interactions with inhibitors of P-gp are not expected. 
Klinično pomembne interakcije z inhibitorji P-gp niso pričakovane.
Vaccination with live or attenuated live vaccines should be avoided during and after cladribine treatment as long as the patient's white blood cell counts are not within normal limits. 
Cepljenju z živimi ali živimi oslabljenimi cepivi se moramo med in po zdravljenju s kladribinom izogibati, dokler bolnikovo število belih krvnih celic ni znotraj normalnih meja.
Concomitant use of other oral medicinal products 
Sočasna uporaba drugih peroralnih zdravil
Patients with secondary progressive MS were excluded in the CLARITY study. 
Bolniki s sekundarno progresivno MS so bili izključeni iz študije CLARITY.
Pack sizes of 1, 4, 5, 6, 7 or 8 tablets. 
Velikosti pakiranja 1, 4, 5, 6, 7 ali 8 tablet.
These may be the symptoms of a rare brain disorder caused by infection and called progressive multifocal leukoencephalopathy (PML). 
Lahko gre za simptome redke bolezni možganov, povzročene z okužbo, ki se imenuje progresivna multifokalna levkoencefalopatija (PML).
In the left column of the table below find the row that fits your body weight (in kg), and then check the number of tablets that should be in the pack(s) for the treatment week you will be starting. 
V levem stolpcu spodnje preglednice poiščite vrstico, ki ustreza vaši telesni masi (v kg), in nato preverite število tablet, ki mora biti v pakiranju(-jih) za teden zdravljenja, ki ga boste začeli.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. 
Če vam je zdravnik povedal, da imate intoleranco za nekatere sladkorje, se pred uporabo tega zdravila posvetujte z zdravnikom.
If a daily dose consists of two tablets, both tablets are taken together as a single dose. 
Če sestavljata dnevni odmerek dve tableti, se obe tableti vzameta skupaj, kot en odmerek.
The bioavailability of 10 mg oral cladribine was approximately 40%. 
Biološka uporabnost 10 mg peroralnega kladribina je bila približno 40 %.
• A reminder to carefully consider data on blood count monitoring and screening for latent infections before starting the treatment; 
• opomnik, da je treba natančno upoštevati podatke o spremljanju krvne slike in presejalnem pregledu zaradi latentnih okužb pred začetkom zdravljenja;
- Thoroughly wash your hands after handling the tablets. 
- Temeljito si operite roke, potem ko ste rokovali s tabletami.
In the overall study population, the median age was 39 years (range 18 to 65), and the female to male ratio was approximately 2:1. 
V celotni preiskovani populaciji je bila mediana starosti 39 let (razpon 18 do 65), pri čemer je bilo razmerje med ženskami in moškimi približno 2:1.
Your immune system must have recovered before you can be vaccinated, and blood tests will check this. 
Vaš imunski sistem mora najprej okrevati, preden ste lahko cepljeni, in da se to ugotovi, je potrebna krvna preiskava.
Place your hand under the blister pack and push 1 or 2 tablet(s) into your hand, according to your prescribed dose. 
Roko namestite pod pretisni omot in potisnite 1 ali 2 tableti v dlan, skladno s predpisanim odmerkom.
Because of these expression levels, cells of the innate immune system are less affected than cells of the adaptive immune system. 
Zaradi teh ekspresijskih ravni so celice naravnega imunskega sistema prizadete manj kot celice prilagojenega imunskega sistema.
There is no known specific antidote to an overdose of cladribine. 
Ni znanega specifičnega antidota za preveliko odmerjanje kladribina.
Pharmacotherapeutic group: Selective Immunosuppressants, ATC code: L04AA40 
Farmakoterapevtska skupina: Zdravila za selektivno zaviranje imunske odzivnosti, oznaka ATC: L04AA40
Particular attention is recommended for patients who have no history of exposure to varicella zoster virus. 
Posebna pozornost se priporoča pri bolnikih, ki v anamnezi nimajo izpostavljenosti virusu varicella zoster.
Although cladribine may have a potential for genotoxicity, long-term data in mice and monkeys did not provide any evidence of a relevant increased carcinogenicity risk in humans. 
Čeprav je kladribin potencialno genotoksičen, dolgoročni podatki pri miših in opicah niso dali nobenih dokazov o relevantnem povečanem tveganju za rakotvornost pri ljudeh.
Each pack contains 1, 4, 5, 6, 7 or 8 tablets in a blister, sealed in a cardboard wallet and fixed in a child-resistant carton. 
Vsako pakiranje vsebuje 1, 4, 5, 6, 7 ali 8 tablet v pretisnem omotu, zaprtem v kartonski zgibanki in pritrjenem v za otroke varni škatli.
As a precautionary measure, you should follow standard cancer screening recommendations, as advised by your doctor. 
Zato morate kot previdnostni ukrep upoštevati standardne smernice glede presejalnih pregledov za raka, ki vam jih svetuje vaš zdravnik.
The following definitions apply to the frequency terminology used hereafter: 
V nadaljevanju se uporabljajo naslednje navedbe pogostnosti:
A small study in cancer patients has shown a cerebrospinal fluid/plasma concentration ratio of approximately 0.25. 
Majhna študija na bolnikih z rakom je pokazala razmerje koncentracije v cerebrospinalni tekočini/plazmi približno 0,25.
- Do not leave your tablet(s) exposed on surfaces, for example on a table, or handle the tablet longer than necessary. 
- Tablet(e) ne puščajte izpostavljenih(e) na površini, na primer na mizi, in s tableto ne rokujte dlje časa, kot je to potrebno.
If this is not possible, dose reduction to the minimum mandatory dose of medicinal products containing these compounds, separation in the timing of administration and careful patient monitoring is recommended. 
Če to ni možno, se priporoča zmanjšanje odmerka na najmanjši potrebni odmerek zdravila, ki vsebuje te spojine, časovni razmik med dajanjem enega in drugega zdravila in skrbno nadziranje bolnika.