natgillin/translations-raw huggingface dataset:
Depending on individual patient response, a lower dose of amitriptyline should be considered if a strong CYP2D6 inhibitor (e.g. bupropion, quinidine, fluoxetine, paroxetine) is added to amitriptyline treatment (see section 4.5). 
Glede na odziv bolnika je treba razmisliti o nižjem odmerku amitriptilina, če se zdravljenju z amitriptilinom doda močan zaviralec CYP2D6 (npr. bupropion, kinidin, fluoksetin, paroksetin) (glejte poglavje 4.5).
• diuretics (“water tablets” e.g. furosemide) 
• diuretiki (tablete za odvajanje vode, npr. furosemid)
Use caution when using amitriptyline and methadone concomitantly due to a potential for additive effects on the QT interval and increased risk of serious cardiovascular effects. 
Pri sočasni uporabi amitriptilina in metadona je potrebna previdnost zaradi možnih aditivnih učinkov na interval QT in povečanega tveganja za resne kardiovaskularne učinke.
As with other tricyclic antidepressants, amitriptyline should not be given to patients receiving monoamine oxidase inhibitors (MAOIs). 
Tako kot drugih tricikličnih antidepresivih se tudi amitriptilina ne sme dajati bolnikom, ki prejemajo zaviralce MAO.
Bed-wetting at night Your doctor will evaluate if the treatment should be continued after 3 months. 
Zdravnik bo ocenil, ali naj po 3 mesecih nadaljujete zdravljenje.
X contains less than 1 mmol sodium (23 mg) per dose, i.e. essentially ‘sodium- free'. 
To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni ‘brez natrija'.
administration of 40-60 mg amitriptyline hydrochloride was 10.1-27.8 h and of 15 mg 15.5-19.5 h. In elderly subjects the half-life is prolonged. 
aplikaciji 40 - 60 mg amitriptilinijevega klorida je bil 10,1 - 27,8 ure in za 15 mg 15,5 - 19,5 ure za odmerek po 15 mg.
Patients with liver diseases or people known as “poor metabolisers” usually receive lower doses. 
Bolniki z boleznijo jeter ali bolniki s »slabo presnovo« običajno prejmejo manjše odmerke zdravila.
The score line facilitates breaking of the tablet into 4 equal doses. 
Razdelilna zareza olajša lomljenje tablete na 4 enake dele.
• medicines used to treat some mental illnesses (e.g. pimozide and sertindole) 
• zdravila za zdravljenje nekaterih duševnih bolezni (npr. pimozid in sertindol)
• Anticholinergic drugs such as certain medicines to treat Parkinsons disease and gastrointerstinal disorders (e.g. atropine, hyoscyamine) 
• antiholinergiki, kot so nekatera zdravila za zdravljenje Parkinsonove bolezni in prebavnih motenj (npr. atropin, hiosciamin)
Neuropathic pain, chronic tension type headache and migraine prophylaxis Your doctor will adjust the medication according to your symptoms and your response to the treatment. 
Nevropatska bolečina, preprečevanje kroničnega glavobola tenzijskega tipa in preprečevanje migrene Zdravnik bo odmerek zdravila prilagodil glede na simptome pri vas in vaš odziv na zdravljenje.
• if you are taking medicines known as monoamine oxidase inhibitors (MAOIs) 
• če jemljete zdravila, imenovana zaviralci monoaminooksidaze (MAO)
• phenytoin and carbamazepine (used to treat epilepsy) 
• fenitoin in karbamazepin (uporabljata se za zdravljenje epilepsije)
The apparent volume of distribution (Vd)β estimated after intravenous administration is 1221±280 l; range 769-1702 l (16±3 l/kg). 
Navidezni volumen porazdelitve (Vd)β, ocenjen po intravenski uporabi, je 1221 l ± 280 l; razpon 7691702 l (16 ± 3 l/kg).
Other metabolites such as cis- and trans-10-hydroxyamitriptyline and cis- and trans-10-hydroxynortriptyline have the same profile as nortriptyline but is considerably weaker. 
Drugi presnovki, kot so cis- in trans-10-hidroksiamitriptilin ter cis- in trans-10-hidroksinortriptilin, imajo enak profil kot nortriptilin, a so dosti bolj šibki.
• enlarged prostate 
• povečano prostato
Adrenergic neurone blockers: Tricyclic antidepressants may counteract the antihypertensive effects of centrally acting antihypertensives such as guanethidine, betanidine, reserpine, clonidine and methyldopa. 
Zaviralci adrenergičnih nevronov: Triciklični antidepresivi lahko izničijo antihipertenzivne učinke centralno delujočih antihipertenzivov, kot so gvanetidin, betanidin, reserpin, klonidin in metildopa.
• methadone (used to treat pain and for detoxification) 
• metadon (uporablja se za lajšanje bolečin in za razstrupljevanje)
• adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (these may be present in cough or cold medicine, and in some anaesthetics) 
• adrenalin, efedrin, izoprenalin, noradrenalin, fenilefrin in fenilpropanolamin (prisotni so lahko v zdravilih proti kašlju ali prehladu in v nekaterih anestetikih)
Regular reassessment is recommended to confirm that continuation of the treatment remains appropriate for the patient. 
Za potrditev primernosti zdravljenja za bolnika, se priporočajo redne ponovne ocene zdravljenja.
Discontinuation of treatment 
Prenehanje zdravljenja
The analgesic effect is normally seen after 2 - 4 weeks of dosing. 
Analgetični učinek je običajno opazen po 2 do 4 tednih zdravljenja.
Electrolyte disturbances (hypokalaemia, hyperkalaemia, hypomagnesaemia) are known to be conditions increasing the proarrythmic risk. 
Znano je, da motnje v ravnovesju elektrolitov (hipokaliemija, hiperkaliemija, hipomagneziemija) povečajo tveganje za aritmije.
If you use antidepressants such as Selective Serotonin Re-uptake Inhibitors (SSRIs), your doctor might consider to changing the dose of your medicine (see also section 2 Other medicines and X and section 3) 
Če uporabljate antidepresive, kot so selektivni zaviralci ponovnega privzema serotonina (SSRI), se lahko zdravnik odloči, da vam spremeni odmerek zdravila (glejte tudi poglavje 2, »Druga zdravila in zdravilo X« in poglavje 3)
This medicine should only be prescribed by doctors with expertise in treating patients with persistent bed-wetting. 
To zdravilo lahko predpiše samo zdravnik z izkušnjami pri zdravljenju bolnikov s trdovratnim močenjem postelje.
Read all of this leaflet carefully before this medicine is administered to you because it contains important information for you. 
Preden vam bodo dali to zdravilo, natančno preberite navodilo, ker vsebuje za vas pomembne podatke!
Tramadol: Concomitant use of tramadol (a CYP2D6 substrate) and tricyclic antidepressants (TCAs), such as amitriptyline increases the risk for seizures and serotonin syndrome. 
Tramadol: Sočasna uporaba tramadola (substrat CYP2D6) in tricikličnih antidepresivov (TCA), kot je amitriptilin, poveča tveganje za epileptične napade in serotoninski sindrom.
In the case of acute surgery, the anaesthetist should be informed about the treatment of amitriptyline. 
V primeru nujnega kirurškega posega morate anesteziologa obvestiti, da se zdravite z amitriptilinom.
Doses above 75 mg should be used with caution. 
Odmerke, večje od 75 mg, je treba uporabljati previdno.
Amitriptyline may induce side effects similar to other tricyclic antidepressants. 
Amitriptilin lahko povzroči neželene učinke, podobne tistim pri drugih tricikličnih antidepresivih.
The daily dose may be increased up to 100 mg - 150 mg, depending on individual patient response and tolerability. 
Dnevni odmerek se lahko povečuje do 100 mg - 150 mg, odvisno od odziva posameznega bolnika in prenašanja zdravila.
Amitriptyline reduced the pregnancy rate in rats (see section 5.3). 
Pri podganah je amitriptilin zmanjšal stopnjo brejosti (glejte poglavje 5.3).
X can also be injected into a big muscle (i.m. 
Zdravilo X se lahko injicira tudi v veliko mišico (i.m.
If required, the available dose range can be exploited. 
Če je potrebno, je treba določiti razpon odmerkov.
Thoughts of suicide and worsening of your depression If you are depressed, you can sometimes have thoughts of harming or killing themselves. 
Če ste depresivni, vas lahko včasih obdajajo misli, da bi se poškodovali ali naredili samomor.
Potential for amitriptyline to affect other medicinal products 
Možnost vpliva amitriptilina na delovanje drugih zdravil
Do not give flumazenil to reverse benzodiazepine toxicity in mixed overdoses. 
Za zmanjšanje toksičnosti benzodiazepinov se ne sme uporabljati flumazenila v prevelikih odmerkih.
Nervous system disorders Very common Somnolence, tremor, dizziness, headache, drowsiness, speech disorder (dysarthria). 
Bolezni živčevja zelo pogosti somnolenca, tremor, omotica, glavobol, dremavost, motnja govora (disartrija)
Caution is also advised for co-administration of amitriptyline and diuretics inducing hypokalaemia (e.g. furosemide) 
Previdnost je potrebna tudi pri sočasnem dajanju amitriptilina in diuretikov, ki inducirajo hipokaliemijo (npr. furosemid).
Take this medicine 1-1½ hours before bedtime. 
Zdravilo je treba vzeti 1-1,5 ure pred spanjem.
Tricyclic antidepressants and neuroleptics mutually inhibit the metabolism of each other; this may lead to a lowered convulsion threshold, and seizures. 
Triciklični antidepresivi in nevroleptiki lahko svojo presnovo vzajemno zavirajo; to lahko povzroči nižji prag za konvulzije in epileptične napade.
Those parts currently not needed can be stored in the reservoir of the tablet box. 
Dele, ki jih trenutno ne potrebujete, lahko shranite v predalček škatle za tablete.
Steady state plasma levels of amitriptyline + nortriptyline are reached within a week for most patients, and in steady state the plasma level comprises approximately equal parts of amitriptyline and nortriptyline around the clock following treatment with conventional tablets 3 times a day. 
Plazemska koncentracija amitriptilina + nortriptilina v stanju dinamičnega ravnovesja je pri večini bolnikov dosežena v enem tednu, plazemska koncentracija v stanju dinamičnega ravnovesja po 24 urah je pri zdravljenju z običajnimi tabletami trikrat na dan.v približno enakih delih sestavljena iz amitriptilina in nortriptilina.
• halofantrine (used to treat malaria) 
• halofantrin (uporablja se za zdravljenje malarije)
Do not stop the treatment without consulting your doctor first. 
Ne prenehajte uporabljati zdravila, ne da bi se posvetovali z zdravnikom.
• narrow angle glaucoma (loss of vision due to abnormally high pressure in the eye) 
• glavkom ozkega zakotja (izgubo vida zaradi nenormalno visokega tlaka v očesu)
Depending on your response to the medicine, your doctor may gradually increase the dose. 
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča.
The dosage therefore can be increased in 25 mg amitriptyline hydrochloride steps>. 
Odmerek se lahko zato povečuje postopno po 25 mg amitriptilinijevega klorida.>
Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucraseisomaltase insufficiency should not receive this medicine.> 
Bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali pomanjkanjem saharoza-izomaltaze ne smejo jemati tega zdravila.>
If you have taken this medicine during the last part of the pregnancy, the newborn may have withdrawal symptoms such as irritability, increased muscle tension, tremor, irregular breathing, poor drinking, loud crying, urinary retention, and constipation. 
Če ste to zdravilo jemali v zadnjem obdobju nosečnosti, se bodo mordapri novorojenčku pojavili odtegnitveni simptomi, kot so razdražljivost, povečana mišična napetost, tremor, neredno dihanje, slabo pitje, glasno jokanje, zastajanje seča in zaprtje.
If necessary, the dose can be increased by 25 mg every other day up to 150 mg daily divided into two doses. 
Po potrebi se lahko odmerek poveča po 25 mg vsak drugi dan do 150 mg na dan, razdeljeno na dva odmerka.
Do not give this medicine to children and adolescents aged below 18 years for these treatments, as safety and efficacy have not been established in this age group. 
Tega zdravila ne dajajte otrokom in mladostnikom, mlajšim od 18 let, ker pri tej starostni skupini varnost in učinkovitost nista bili dokazani.
After prolonged administration, abrupt cessation of therapy may produce withdrawal symptoms such as headache, malaise, insomnia and irritability. 
Po daljši uporabi lahko nenadno prenehanje zdravljenja povzroči odtegnitvene simptome, kot so glavobol, splošno slabo počutje, nespečnost in razdražljivost.
In the listing below the following convention is used: MedDRA system organ class / preferred term Very common (> 1/10); 
V spodnji preglednici je uporabljen naslednji dogovor: Organski sistemi/prednostni izraz po MedDRA;
Known poor metabolisers of CYP2D6 or CYP2C19 
Znani slabi presnavljalci s CYP2D6 ali CYP2C19
Cytochrome P450 inhibitors of CYP2D6 
Zaviralci citokroma P450 CYP2D6
paresthesia, ataxia. 
• driska, bruhanje
• epilepsy, a history of convulsions or fits 
• epilepsijo, konvulzije ali krče v anamnezi
CNS depressants: Amitriptyline may enhance the sedative effects of alcohol, barbiturates and other CNS depressants. 
Zaviralci osrednjega živčevja: Amitriptilin lahko poveča sedativne učinke alkohola, barbituratov in drugih zaviralcev osrednjega živčevja.
• rifampicin (to treat infections) 
• rifampicin (uporablja se za zdravljenje okužb)
All the metabolites have less anticholinergic activity than amitriptyline and nortriptyline. 
Vsi presnovki imajo šibkejše antiholinergično delovanje kot amitriptilin in nortriptilin.
Cytochrome P450 inducers: Oral contraceptives, rifampicin, phenytoin, barbiturates, carbamazepine and St. John's Wort (Hypericum perforatum) may increase the metabolism of tricyclic antidepressants and result in lowered plasma levels of tricyclic antidepressants and reduced antidepressant response. 
Induktorji citokroma P450: Peroralni kontraceptivi, rifampicin, fenitoin, barbiturati, karbamazepin in šentjanževka (Hypericum perforatum) lahko povečajo presnovo tricikličnih antidepresivov in povzročijo zmanjšanje ravni tricikličnih antidepresivov v plazmi in zmanjšan odziv na antidepresive.
The daily dose may be increased up to 100 mg - 150 mg divided into two doses, depending on individual patient response and tolerability. 
Dnevni odmerek se lahko povečuje do 100 mg - 150 mg, razdeljeno na dva odmerka, odvisno od odziva posameznega bolnika in prenašanja.
Patients with a history of suicide-related events, or those exhibiting a significant degree of suicidal ideation prior to commencement of treatment, are known to be at greater risk of suicidal thoughts or suicide attempts, and should receive careful monitoring during treatment. 
Znano je, da je tveganje za samomorilne misli ali poskuse samomora pri bolnikih z anamnezo s samomorom povezanih dogodkov, in pri bolnikih, ki kažejo samomorilno mišljenje že pred začetkom zdravljenja, večje, zato jih je treba med zdravljenjem skrbno nadzirati.
Check urea and electrolytes-look for low potassium and monitor urine output. 
Preverjanje vrednosti sečnine in elektrolitov - posebna pozornost glede nizkih vrednosti kalija in izločanja urina.
injection 
injiciranje
Examine for clinical features. 
Klinični pregled.
NAME OF THE MEDICINAL PRODUCT Saroten and associated names 2 ml, 50 mg solution for injection 
IME ZDRAVILA Saroten in povezana imena 2 ml, 50 mg raztopina za injiciranje
• St. John´s Wort (hypericum perforatum) - a herbal remedy used for depression 
• šentjanževka (Hypericum perforatum) - rastlinski pripravek, ki se uporablja za zdravljenje depresije
<[Saroten and associated names prolonged-release capsules, hard ] When the prolonged-release capsules are administered in the evening the concentration of amitriptyline is highest late in the night and decreases during the day whilst the concentration of nortriptyline is constant around the clock and thus predominates during daytime. 
<[Saroten in povezana imena trde kapsule s podaljšanim sproščanjem] Pri dajanju kapsul s podaljšanim sproščanjem zvečer je koncentracija amitriptilina največja pozno ponoči, nato pa se čez dan zmanjšuje, medtem ko je koncentracija nortriptilina konstantna 24 ur in prevladuje tekom dneva.>
The dosage therefore can be increased in 25 mg amitriptyline hydrochloride steps. 
Odmerek se lahko zato povečuje postopno po 25 mg amitriptilinijevega klorida.
The mean absolute oral bioavailability is 53% (Fabs = 0.527±0.123; range 0.219-0.756). 
Povprečna absolutna biološka uporabnost je 53 % (Fabs = 0,527 ± 0,123; razpon
- A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG). 
• težava s srcem, imenovana »podaljšanje intervala QT« (to je vidno na elektrokardiogramu,
• diabetes as you might need and adjustment of your antidiabetic medicine. 
• sladkorno bolezen, saj bo morda treba prilagoditi odmerke vaših zdravil za zdravljenje sladkorne bolezni.
• severe heart disease 
• hudo bolezen srca
Oral administration of tablets results in maximum serum levels in about 4 hours. 
Maksimalne koncentracije v serumu so bile dosežene v približno 4 urah po peroralni uporabi tablet.
The tablets are swallowed with water independent of meals.> 
Tablete pogoltnite cele z vodo, ne glede na obroke hrane.>
If your doctor has told you that you have intolerance to some sugars, contact your doctor before taking this medicine.> 
Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred uporabo tega zdravila posvetujte s svojim zdravnikom.>
Potential of other medicinal products to affect amitriptyline 
Možnost vpliva drugih zdravil na delovanje amitriptilina
Your doctor will decide when and how to stop your treatment to avoid any unpleasant symptoms that might occur if it is stopped abruptly (e.g. headache, feeling unwell, sleeplessness and irritability). 
Zdravnik se bo odločil, kdaj in kako boste prenehali zdravljenje, da se prepreči pojav morebitnih neprijetnih simptomov, ki se lahko pojavijo pri nenadnem prenehanju (npr. glavobol, slabo počutje, nespečnost in razdražljivost).
• medicines to treat fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole) 
• zdravila za zdravljenje glivičnih okužb (npr. flukonazol, terbinafin, ketokonazol in itrakonazol)
Not known (cannot be estimated from the available data). 
Neznana (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti).
Warnings and precautions Talk to your doctor or pharmacist before taking X. 
Opozorila in previdnostni ukrepi Preden prejmete zdravilo X, se posvetujte z zdravnikom ali farmacevtom.
Amitriptyline is a sedative drug. 
Amitriptilin je pomirjevalo.
Do not use this medicine after the expiry date which is stated on the label afterr EXP. 
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
<[Saroten and associated names 75 mg, modified release tablets] In contrast to the tablet serum curves which show a distinct initial peak, the modified release tablets curves rise slowly to a plateau level with lower concentrations than the peak of the tablet curves. 
<[Saroten in povezana imena 75 mg, tablete s prirejenim sproščanjem] V nasprotju s krivuljami serumske koncentracije za tablete, ki kažejo izrazit začetni vrh, se krivulje tablet s prirejenim sproščanjem počasi dvigajo do platoja, kjer so koncentracije nižje, kot je vrh krivulj za tablete.
Usually the X is added to a solution for infusion. 
Običajno se zdravilo X doda k raztopini za infundiranje.
If your doctor has told you that you have intolerance to some sugars, contact your doctor before taking this medicine. 
Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred uporabo tega zdravila posvetujte s svojim zdravnikom.
Amitriptyline and the main metabolite nortriptyline pass across the placental barrier. 
Amitriptilin in njegov glavni presnovek nortriptilin prehajata skozi placento.
The mean systemic clearance (Cls) is 51.5 ±13.8 l/h, range 25.6-71.8 l/h. 
Povprečni sistemski očistek (Cls) je 51,5 ± 13,8 l/h, razpon 25,6 - 71,8 l/h.
Great care is necessary if amitriptyline is administered to hyperthyroid patients or to those receiving thyroid medication, since cardiac arrhythmias may develop. 
Pri dajanju amitriptilina bolnikom s hipertirozo ali bolnikom, ki prejemajo zdravila za zdravljenje ščitnice, je potrebna velika previdnost, saj lahko pride do srčnih aritmij.
• hypersensitivity inflammation of heart muscle 
• preobčutljivostno vnetje srčne mišice
Severe liver disease. 
Huda bolezen jeter.
Lowered consciousness progressing into coma. 
zmanjšana zavest, ki napreduje v komo, depresija dihanja.
• medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics) 
• zdravila za zdravljenje nekaterih bolezni srca (npr. zaviralci beta in antiaritmiki)
This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis. 
To zdravilo smejo predpisovati samo zdravniki z izkušnjami pri obravnavi trdovratne enureze.
CYP2D6 inhibitors: The CYP2D6 isozyme can be inhibited by a variety of drugs, e.g. neuroleptics, serotonin reuptake inhibitors, beta blockers, and antiarrhythmics. 
Zaviralci CYP2D6: Izoencim CYP2D6 lahko zavirajo številna zdravila, npr. nevroleptiki, zaviralci ponovnega privzema serotonina, zaviralci adrenergičnih receptorjev beta in antiaritmiki.
The mechanism of action also includes ion-channel blocking effects on sodium, potassium and NMDA channel at both central and spinal cord level. 
Mehanizem delovanja vključuje tudi zaviralni učinek ionskih kanalov na kanale natrija, kalija in
Thioridazine: Co-administration of amitriptyline and thioridazine (CYP2D6 substrate) should be avoided due to inhibition of thioridazine metabolism and consequently increased risk of cardiac side effects 
Tioridazin: Sočasnemu dajanju amitriptilina in tioridazina (substrat CYP2D6) se je treba izogibati zaradi zaviranja presnove tioridazina in posledično povečanega tveganja za neželene učinke na srce.
It is advisable to review all antihypertensive therapy during treatment with tricyclic antidepressants. 
Med zdravljenjem s tricikličnimi antidepresivi je priporočljivo spremljati antihipertenzivno zdravljenje.
The antidepressant and analgesic effects usually set in after 2-4 weeks; the sedative action is not delayed. 
Antidepresivni in analgetični učinki običajno nastopijo po 2 do 4 tednih; sedativno delovanje ni zakasnjeno.
Daily doses above 100 mg should be used with caution. 
Dnevne odmerke, večje od 100 mg, je treba uporabljati previdno.
• increased sensitivity to sunlight 
• večja občutljivost na sončno svetlobo • povečanje dojk pri moških
The antidepressant effect usually sets in after 2 - 4 weeks. 
Trajanje zdravljenja Antidepresivni učinek običajno nastopi po 2 - 4 tednih.
The recommended initial dose is 25 mg two times daily. 
Priporočeni začetni odmerek je 25 mg dvakrat na dan.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucosegalactose malabsorption should not receive this medicine. 
Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
Patients (and caregivers of patients) should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present. 
Bolnike (in njihove negovalce) je treba opozoriti, da je potreben nadzor glede kliničnega poslabšanja, samomorilnega vedenja ali misli,
The daily dosage is in general between 1 and 3 ampoules of 2 ml (equivalent to 50-150 mg amitriptyline hydrochloride/day, equivalent to 44.2 - 132.6 mg amitriptyline/day). 
Dnevni odmerek je običajno 1 do 3 ampule po 2 ml (kar ustreza 50 - 150 mg amitriptilinijevega klorida na dan, kar ustreza 44,2 - 132,6 mg amitriptilina na dan).
• Suicidal thoughts and behaviours may also develop during early treatment with antidepressants for disorders other than depression; the same precautions observed when treating patients with depression should therefore be followed when treating patients with enuresis 
• V zgodnjem obdobju zdravljenja z antidepresivi za druge motnje kot depresijo se lahko pojavijo samomorilne misli in vedenje, zato je treba pri zdravljenju bolnikov z enurezo upoštevati iste previdnostne ukrepe kot pri zdravljenju bolnikov z depresijo.