natgillin/translations-raw huggingface dataset:
Slowly and gently push the plunger down to gently squirt the medicine into the inside of your cheek and swallow it. DO NOT forcefully push down the plunger, or squirt the medicine to the back of your mouth or throat, as you may choke. 
Bata NE potiskajte navzdol s silo in zdravila NE brizgajte v zadnji del ust ali žrelo, saj se lahko zadušite.
The myelosuppressive activity may be potentiated by previous or concomitant radiotherapy or cytotoxic therapy. 
Predhodna ali hkratna radioterapija ali citotoksična terapija lahko okrepi mielosupresivno delovanje.
The active substance is hydroxycarbamide. 
Učinkovina je hidroksikarbamid.
As renal excretion is a pathway of elimination, consideration should be given to decreasing the dose of hydroxycarbamide in patients with renal impairment. 
Ledvična okvara Ker je ledvično izločanje glavna pot izločanja, je treba pri bolnikih z ledvično okvaro razmisliti o zmanjšanju odmerka hidroksikarbamida.
Severe anaemia must be corrected with whole blood replacement before initiating therapy with hydroxycarbamide. 
Pred začetkom zdravljenja s hidroksikarbamidom je treba hudo anemijo odpraviti s transfuzijo polne krvi.
Each pack contains one bottle, a bottle adaptor and two dosing syringes (a red syringe graduated to 3 ml and a white syringe graduated to 12 ml). 
Eno pakiranje vsebuje eno steklenico, nastavek za steklenico in dve brizgi za odmerjanje (rdeča brizga je označena z lestvico do 3 ml in bela brizga je označena z lestvico do 12 ml).
How to store Xromi 
Shranjevanje zdravila Xromi
- if you have extreme tiredness, weakness and shortness of breath, which may be symptoms of a lack of red blood cells (anaemia). 
- če ste izredno utrujeni, slabotni in zadihani, saj so to lahko simptomi pomanjkanja rdečih krvničk (anemije), - če hitro zakrvavite ali dobite modrice, saj sta to lahko simptoma nizke ravni trombocitov v krvi, - če imate okvaro jeter (morda bo potrebno dodatno spremljanje),
- Keep the bottle tightly closed to prevent spoilage of the medicine and reduce the risk of accidental spillage. 
Da bo zdravilo ostalo nedotaknjeno in da zmanjšate tveganje nenamernega razlitja, naj bo steklenica tesno zaprta.
In a comparative bioavailability study in healthy adult volunteers (n=28), 500 mg of hydroxycarbamide oral solution was demonstrated to be bioequivalent to the reference 500 mg capsule, with respect to both the peak concentration and area under the curve. 
da je 500 mg peroralne raztopine hidroksikarbamida bioekvivalentnih referenčni 500-miligramski kapsuli, in sicer tako glede najvišje koncentracije kot površine pod krivuljo.
Let the syringe dry completely before you use that syringe again for dosing. 
Pred ponovnim odmerjanjem brizgo posušite do suhega.
The other ingredients are xanthan gum, sucralose (E955), strawberry flavour, methyl parahydroxybenzoate (E218), sodium hydroxide, and purified water. 
Druge sestavine zdravila so ksantanski gumi, sukraloza (E955), aroma jagode,
P value1 
Pvredno st1
Also rates of acute chest syndrome were decreased in those taking hydroxycarbamide when compared with those taking placebo; RR 0.44 (95% CI 0.28 to 0.68) (p < 0.001). 
zmanjšala tudi pogostnost akutnega sindroma bolečine v prsih; RR 0,44 (95-odstotni interval zaupanja: od 0,28 do 0,68) (p < 0,001).
Patients with normal (CrCl> 90 ml/min), mild (CrCl 60-89 ml/min), moderate (CrCl 3059 ml/min), severe (CrCl 15-29 ml/min) renal impairment, and End Stage Renal Disease (CrCL < 15 ml/min) received hydroxycarbamide as a single dose of 15 mg/kg body weight. 
(CrCl 30-59 ml/min) in hudo (CrCl 15-29 ml/min) ledvično okvaro ter končno odpovedjo ledvic
disease and it may cause treatment failure and toxicities (in some cases fatal) in HIV patients (see sections 4.3 and 4.5). 
Hidroksikarbamid se pri okužbi z virusom HIV ne sme uporabljati v kombinaciji s protiretrovirusnimi zdravili, saj lahko pri bolnikih, okuženih z virusom HIV, povzroči neuspešno zdravljenje in toksičnosti (v nekaterih primerih s smrtnim izidom) (glejte poglavji 4.3 in 4.5).
Close monitoring of blood parameters is advised in patients with hepatic impairment. 
Pri bolnikih z jetrno okvaro se priporoča natančno spremljanje krvnih parametrov.
2,000/μL to 4,000/μL) is achieved, up to a maximum of 35 mg/kg/day. 
• povečevanje odmerka se nadaljuje, dokler ni dosežena blaga mielosupresija (absolutno število nevtrofilcev je od 2.000/μl do 4.000/μl), in sicer do največjega dnevnega odmerka 35 mg/kg,
- Isolated cases of malignant disease of blood cells (leukaemia) 
- posamezni primeri malignih bolezni krvnih celic (levkemija) - kožni rak pri starejših bolnikih - virusne okužbe s parvovirusom B19
Any unused product should be disposed of in accordance with local requirements. 
Neuporabljeno zdravilo zavrzite v skladu z lokalnimi predpisi.
• A patient/carer guide 
• vodnik za bolnike/skrbnike.
Embryotoxicity manifesting as decreased foetal viability, reduced live litter sizes, and developmental delays has been reported in species including mice, hamsters, cats, dogs, and monkeys at doses comparable to human doses. 
Pri določenih vrstah živali, vključno z mišmi, hrčki, mačkami, psi in opicami, so pri odmerkih, primerljivih z odmerki pri človeku, poročali o embriotoksičnosti, ki se je izražala kot zmanjšanje viabilnosti plodu, zmanjšano število živih mladičev v leglu in upočasnitve razvoja.
Use in elderly 
Uporaba pri starejših osebah
The total body clearance of hydroxycarbamide in adult patients with Sickle Cell Disease is 0.17L/h/kg. 
Izločanje Celotni telesni očistek hidroksikarbamida pri odraslih bolnikih s srpastoceličnim sindromom je
Hepatotoxicity and hepatic failure resulting in death were reported during post-marketing surveillance in HIV-infected patients treated with hydroxycarbamide and other antiretroviral medicinal products. 
Med spremljanjem v obdobju trženja zdravila so pri bolnikih, ki so okuženi z virusom HIV in so se zdravili s hidroksikarbamidom in drugimi protiretrovirusnimi zdravili, poročali o smrti zaradi hepatotoksičnosti in odpovedi jeter.
Patients who have received irradiation therapy in the past may have an exacerbation of post irradiation erythema when hydroxycarbamide is given. 
Pri bolnikih, ki so bili v preteklosti zdravljeni z obsevanjem, se lahko pri uporabi hidroksikarbamida poslabša eritem po obsevanju.
Strawberry flavour Methyl parahydroxybenzoate (E218) Sodium hydroxide (E524) Purified water 
metilparahidroksibenzoat (E218), natrijev hidroksid in prečiščena voda.
Rare 
neznačilna
Each pack contains one bottle, an HDPE bottle adaptor and 2 polyethylene dosing syringes (a red syringe graduated to 3 ml and a white syringe graduated to 12 ml). 
Eno pakiranje vsebuje eno steklenico, nastavek za steklenico iz HDPE in 2 brizgi za odmerjanje iz polietilena (rdeča brizga je označena z lestvico do 3 ml in bela brizga je označena z lestvico do
Acute mucocutaneous toxicity has been reported in patients receiving hydroxycarbamide at a dosage several times greater than that recommended. 
Pri bolnikih, ki so prejemali hidroksikarbamid v nekajkrat višjih odmerkih od priporočenega, so poročali o akutni mukokutani toksičnosti.
A clinical response to treatment with hydroxycarbamide may take 3-6 months and therefore, a 6month trial on the maximum tolerated dose is required prior to considering discontinuation due to treatment failure (whether due to lack of adherence or failure to respond to therapy). 
zato je pred morebitno prekinitvijo jemanja zdravila zaradi neuspešnega zdravljenja (bodisi zaradi slabše adherence bodisi zaradi neodzivanja na zdravljenje) potrebno šestmesečno preskušanje najvišjega dovoljenega odmerka.
• Patient information pack 
• paket gradiv z informacijami za bolnika.
Skin ulcer, oral, nail and skin hyperpigmentation, dry skin, alopecia 
Bolezni kože in podkožja pogosti kožni ulkus, oralna hiperpigmentacija ter hiperpigmentacija nohtov in kože, suha koža, alopecija občasni izpuščaj redki ulkusi na nogah zelo redki sistemski in kožni eritematozni lupus
Hydroxycarbamide is cytotoxic. 
Hidroksikarbamid je citotoksičen.
What you need to know before you take Xromi 
Kaj morate vedeti, preden boste vzeli zdravilo Xromi Ne jemljite zdravila Xromi:
Xromi can make you feel drowsy. 
Zdravilo Xromi lahko povzroči zaspanost.
Contents of the pack and other information 
Shranjevanje zdravila Xromi Vsebina pakiranja in dodatne informacije
Please contact your doctor immediately if you think you may be pregnant. 
Če menite, da bi lahko bili noseči, o tem nemudoma obvestite zdravnika.
60 children (aged 5-18 years) with three or more blood transfusions or vaso-occlusive crises requiring hospitalisation per year, were randomised to fixed dose 10 mg/mg per day hydroxycarbamide (n=30) or to a matched placebo (n=30). 
zaradi katerih je bila potrebna hospitalizacija, randomizirali za prejemanje fiksnega dnevnega odmerka 10 mg/mg hidroksikarbamida (n = 30) ali ujemajočega se placeba (n = 30).
An increase in HbF and a decrease in absolute neutrophil count were reported in the hydroxycarbamide group. 
V skupini, ki je prejemala hidroksikarbamid, so poročali o zvišanju ravni HbF in zmanjšanju absolutnega števila nevtrofilcev.
Skin cancer has been reported in patients receiving long term hydroxycarbamide. 
Pri bolnikih, ki prejemajo dolgotrajno zdravljenje s hidroksikarbamidom, so poročali o kožnem raku.
In keeping with the mechanism of action of hydroxycarbamide, the MSH study also showed a statistically significant increase in HbF (mean difference 3.9% (95% CI 2.69 to 5.11 (p < 0.0001)) and haemoglobin levels (mean difference 0.6 g/dL (95% CI 0.28 to 0.92, p < 0.0014) and a decrease in haemolytic markers in the groups treated with hydroxycarbamide. 
Študija MSH je v skladu z mehanizmom delovanja hidroksikarbamida prav tako pokazala statistično pomembno zvišanje ravni HbF (povprečna razlika 3,9 % (95-odstotni interval zaupanja: od 2,69 do
NAME OF THE MEDICINAL PRODUCT Xromi 100 mg/ml oral solution hydroxycarbamide 
Xromi 100 mg/ml peroralna raztopina hidroksikarbamid
Talk to your doctor, pharmacist or nurse before taking Xromi: 
Pred začetkom jemanja zdravila Xromi se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro:
It appears that nitroxyl, the corresponding carboxylic acid and nitric oxide are metabolites: Urea has also been shown to be a metabolite of hydroxycarbamide. 
Kaže, da so presnovki nitroksil, ustrezna karboksilna kislina in dušikov oksid.
Blood and lymphatic system disorders 
Bolezni krvi in limfatičnega sistema zelo pogosti depresija kostnega mozga,
Uncommon: may affect up to 1 in 100 people - Itching red eruption of the skin (rash) - Diarrhoea - Vomiting 
Občasni: pojavijo se lahko pri največ 1 od 100 bolnikov - srbeči rdeči kožni izpuščaj (izpuščaj)
There was a statistically significant difference between the hydroxycarbamide group and placebo group in the mean annual crisis rate (all crises), mean difference -2.80 (95% CI -4.74 to -0.86) (p = 0.005), and for crises requiring hospitalisation, mean difference -1.50 (95% CI -2.58 to -0.42) (p = 0.007). 
2,80 (95-odstotni interval zaupanja: od -4,74 do -0,86) (p = 0,005) in glede kriz, v katerih je bila potrebna hospitalizacija: povprečna razlika -1,50 (95-odstotni interval zaupanja: od -2,58 do -0,42) (p = 0,007).
- Inflammation or ulceration of the mouth 
- driska - bruhanje - vnetje ali razjede v ustih - zvišane vrednosti jetrnih encimov
Thrombocytopenia, anaemia 
retikulocitopenijo, makrocitozo pogosti trombocitopenija, anemija
These vasculitic toxicities were reported most often in patients with a history of, or currently receiving, interferon therapy (see section 4.4). 
O teh toksičnih vaskulitisih so najpogosteje poročali pri bolnikih, ki so bili v preteklosti ali v času terapije zdravljeni z interferonom
Two dosing syringes (a red syringe graduated to 3 ml and a white syringe graduated to 12 ml) are provided for accurate measurement of the prescribed dose of the oral solution. 
Za natančno odmerjanje predpisanega odmerka peroralne raztopine sta priloženi dve brizgi (rdeča brizga je označena z lestvico do 3 ml in bela brizga je označena z lestvico do 12 ml).
You should protect your skin from the sun and regularly inspect your skin yourself during the treatment and after discontinuation of the therapy with hydroxycarbamide. 
Med zdravljenjem in po prenehanju zdravljenja s hidroksikarbamidom si morate kožo zaščititi pred soncem in si jo redno pregledovati.
Infections and infestations 
Preiskave in pregledi
To minimise air bubbles, the bottle should not be shaken prior to dosing. 
Pred dajanjem odmerka ne pretresite steklenice, da čim bolj omejite nastanek zračnih mehurčkov.
o Teratogenicity and male fertility; Need for contraception; Breast feeding; o Growth follow-up in children; - Key signs and symptoms of serious adverse reactions; - Information on crisis or infections; When to seek urgent attention from the health care provider 
o okvara ledvic in/ali jeter, o teratogenost in plodnost moških, potreba po kontracepciji, dojenje, o spremljanje rasti otrok;
You should not take Xromi if you have severe kidney disease. 
Če imate hudo ledvično okvaro, ne smete jemati zdravila Xromi.
Leg ulcers 
Ulysses House
Cutaneous vasculitic toxicities including vasculitic ulcerations and gangrene have occurred in patients with myeloproliferative disorders during therapy with hydroxycarbamide. 
Pri bolnikih z mieloproliferativnimi motnjami so se med zdravljenjem s hidroksikarbamidom pojavili toksični kožni vaskulitisi, vključno z vaskulitičnimi ulkusi in gangreno.
Elevated liver enzymes, Hepatotoxicity 
Bolezni jeter, žolčnika in žolčevodov občasni zvišane vrednosti jetrnih encimov, hepatotoksičnost
Put on disposable hand gloves before handling Xromi. 
Pred rokovanjem z zdravilom Xromi nataknite rokavice za enkratno uporabo.
The Guide for healthcare professionals shall contain the following key elements: - Indication, dosage and dose adjustment; - Description of safe handling of Xromi, including the risk of medication error due to the use of two different dosing syringes; - Warnings about important risks associated with using Xromi: o Switching patients from capsule and tablet to liquid formulation; o Haematological toxicity, use of other myelosuppressive agent or radiation therapy; o Concomitant use of nucleoside analogue reverse transcriptase inhibitors; o Skin ulceration and vasculitis, leg ulcers; o Long-term safety, in particular the development of malignancies (leukaemia, skin cancer); o Teratogenicity and male fertility; Need for contraception; Breast feeding; o Adverse drug reactions most frequently reported; - Follow-up of patients treated with Xromi: o Haematological follow-up and dose adjustment; o Follow-up of patients with renal and/or hepatic impairment; o Growth follow-up in children; 
o prehod bolnikov s kapsul in tablet na tekočo obliko zdravila, o hematološka toksičnost, uporaba drugih mielosupresivnih zdravil ali radioterapije, o sočasna uporaba analogov nukleozidnih zaviralcev reverzne transkriptaze, o kožni ulkusi in vaskulitis, ulkusi na nogah,
In all clinical studies, there was a significant increase in 
Pri vseh kliničnih študijah so po uporabi hidroksikarbamida opazili znaten porast HbF v primerjavi z izhodiščem.
Hydroxycarbamide can cause foetal harm when administered to a pregnant woman. 
Če se hidroksikarbamid da nosečnici, lahko škoduje plodu.
Adverse reactions affecting the skin and subcutaneous tissue such as darkening of the skin nail beds, dry skin, skin ulcers, and alopecia tend to occur following several years of long-term daily maintenance therapy. 
kožni ulkusi in alopecija, se običajno pojavijo po več letih dolgotrajne vsakodnevne vzdrževalne terapije.
Hydroxycarbamide is an orally active antineoplastic agent. 
Mehanizem delovanja Hidroksikarbamid je peroralno aktivno zdravilo z delovanjem na novotvorbe.
Oligospermia, azoospermia 
Motnje reprodukcije in dojk zelo pogosti oligospermija, azoospermija neznana amenoreja
- if you have a liver disease (additional monitoring may be needed) - if you have a kidney disease (the dose may be adjusted) - if you have leg ulcers - if you have a known lack of vitamin B12 or folate 
- če imate ulkuse na nogah, - če imate znano pomanjkanje vitamina B12 ali folatov.
Full blood cell count with white cell differential and reticulocyte count should be monitored every 2 weeks for the first 2 months following treatment initiation. 
Prva dva meseca po začetku zdravljenja je treba število vseh krvnih celic, vključno z diferencialno belo krvno sliko in številom retikulocitov,
Gastrointestinal disturbances, gastrointestinal ulcer, severe hypomagnesaemia 
Bolezni prebavil pogosti navzea, zaprtost občasni stomatitis, driska, bruhanje neznana prebavne motnje, gastrointestinalna razjeda, huda hipomagneziemija
Posology 
Razpon
Range 
SERIJ
Hydroxycarbamide administered to male rats at 60 mg/kg body weight/day (about double the recommended usual maximum dose in humans) produced testicular atrophy, decreased spermatogenesis and significantly reduced their ability to impregnate females. 
(približno dvakratni odmerek priporočenega najvišjega odmerka za človeka), je povzročil atrofijo mod, zmanjšanje spermatogeneze in bistveno zmanjšano sposobnost za oploditev samic.
Mean corpuscular haemoglobin concentration (MCHC) (%) 
Povprečna koncentracija neznačilna hemoglobina v eritrocitu (MCHC)
- if you take antiretroviral medicines for the treatment of Human Immunodeficiency Virus (HIV), 
- če ste noseči ali dojite (glejte poglavje „Nosečnost, dojenje in plodnost“), - če jemljete protiretrovirusna zdravila za zdravljenje virusa humane imunske pomanjkljivosti
Stomatitis, diarrhoea, vomiting 
Bolezni živčevja pogosti glavobol, omotica
Platelets (×109/L) 
Trombociti (× 109/l) 443,2 ± 189,1
- Inflammation of the skin causing red scaly patches and possibly occurring together with pain in the joints 
Zelo redki: pojavijo se lahko pri največ 1 od 10.000 bolnikov - vnetje kože, ki povzroča nastajanje rdečih, luskastih zaplat in se lahko pojavlja skupaj z bolečinami v sklepih
Speak to your doctor if you are concerned by any of these side effects. 
Če ste zaskrbljeni zaradi katerega od teh neželenih učinkov, se posvetujte z zdravnikom.
After 18 months of treatment, there was a significant difference in the number of vaso-occlusive crises between the hydroxycarbamide group and placebo group, mean difference 
P-vrednost je za primerjavo med skupinama s hidroksikarbamidom oziroma placebom pri 18 mesecih.
Reproductive system and breast disorders 
Ženske v rodni dobi/kontracepcija pri moških in ženskah
In a randomised, double-blind, placebo controlled study conducted in a tertiary hospital in India, 
V randomizirani, dvojno slepi, s placebom kontrolirani študiji v terciarni bolnišnici v Indiji so 60 otrok (starih 5-18 let), ki so na leto imeli tri ali več transfuzije krvi ali vazookluzivne krize,
Package leaflet: Information for the user Xromi 100 mg/ml oral solution hydroxycarbamide Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. 
Pred začetkom jemanja zdravila natančno preberite navodilo, ker vsebuje za vas pomembne podatke!
Intravenous administration should not be protracted over more than 2 hours. 
Z intravenskim dajanjem se ne sme odlašati več kot dve uri.
The use of television monitor systems to monitor the patients is recommended. 
Priporočljiva je uporaba sistemov s televizijskim monitorjem za spremljanje bolnikov.
ICRP-30 data 
Podatki ICRP-30
Email: quality@idb-radiopharmacy.com 
E-pošta: quality@idb-radiopharmacy.com
The ART is defined as the end of production. 
ART je določen kot konec izdelave.
Precautions with respect to relatives, carers and hospital staff are provided in section 6.6. 
Previdnostni ukrepi, namenjeni sorodnikom, negovalcem in bolnišničnemu osebju, so navedeni v poglavju 6.6.
Effects of the respiration were slight and variable. 
Učinki na dihanje so bili rahli in spremenljivi.
MARKETING AUTHORISATION NUMBER(S) EU/1/15/1013/001 
ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET Z ZDRAVILOM EU/1/15/1013/001
(GBq: GigaBecquerel is the unit in which radioactivity is measured). 
(GBq: gigabekerel je enota za merjenje radioaktivnosti).
However, in case of an overdose, you will receive the appropriate treatment. 
Če kljub temu pride do prevelikega odmerjanja, boste prejeli ustrezno zdravljenje.
Also low gamma energy is emitted, for instance at 113 keV (6.2%) and 208 keV (11%). 
Prav tako prihaja do emisije nizkoenergijskih gama žarkov, npr. 113 keV (6,2 %) in 208 keV (11 %).
No gross differentiating changes were found of the tissues demonstrating no evidence of acute damage resulting from the experiment. 
V tkivih niso odkrili večjih diferencialnih sprememb, zato niso našli dokazov o akutnih poškodbah, ki bi nastale zaradi eksperimenta.
This is below the threshold considered acceptable for discharge from the clinic (20 µSv/h). 
Ta stopnja je pod pragom, ki ga upoštevamo za sprejemljivega za odpust s klinike (20 µSv/h).
Activity measurements using an ionization chamber are very sensitive to geometric factors and therefore should be performed only under geometric conditions which have been appropriately validated. 
Meritve aktivnosti z uporabo ionizacijske celice so zelo občutljive na geometrične faktorje in jih je zaradi tega treba izvajati samo pod geometričnimi pogoji, ki so bili primerno validirani.
It appeared that more than 78% of the doses was distributed into liver, bone and spleen. 
Ugotovili so, da se je več kot 78 % odmerkov porazdelilo v jetra, kosti in vranico.
Client code: 
Šifra stranke:
For minimising radiation exposure resulting from repeated exposure, there is no specific recommendation except the strict observance of the above ones. 
Za zmanjšanje izpostavljenosti sevanju, do katere prihaja ob ponavljajoči se izpostavljenosti, ni specifičnih priporočil, z izjemo strogega upoštevanja zgoraj navedenih.
However, a post-exposure interval >1 hour does not preclude the administration and effective action of chelator with reduced efficiency. 
Kljub temu pa interval > 1 ure po izpostavljenosti ne izključuje dajanja in uspešnega delovanja kelatorja z zmanjšano učinkovitostjo.
Fax: +31(0)13 5079 912 
Faks: +31 (0)13 5079 912
Electrocardiograms showed no irregularities in cardiac rhythm or conduction. 
Elektrokardiogrami niso pokazali nepravilnosti v srčnem ritmu ali prevodnosti.
Radiation protection 
Zaščita pred sevanjem
Do not use this medicine after the expiry date and time which are stated on the label after EXP. 
Tega zdravila ne smete uporabljati po datumu in času izteka roka uporabnosti, ki sta navedena na nalepki poleg oznake EXP.
With respect to the distribution pattern in blood it appeared that 2 h after administration 15% of the Lutetium as being present in blood, had entered the blood cells with the remaining 85% still being present in the serum. 
Glede na vzorec porazdelitve v krvi, so ugotovili, da je dve uri po dajanju 15 % lutecija, ki je bil prisoten v krvi, vstopilo v krvne celice, preostalih 85 % pa je bilo še vedno prisotnih v serumu.
8 days from the date of ART (= end of production). 
6.3 Rok uporabnosti 8 dni od datuma ART (= konec izdelave).
No special storage condition required. 
Ni posebnih pogojev za shranjevanje.
The chelating efficacy is greatest immediately or within one hour of exposure when the radionuclide is circulating in or available to tissue fluids and plasma. 
Učinkovitost keliranja je največja takoj ali eno uro po izpostavljenosti, ko radionuklid kroži ali se nahaja v tkivnih tekočinah in plazmi.
In all cases, it is necessary to ensure that the risks of the radiation are less than from the disease itself. 
V vseh primerih je treba zagotoviti, da so tveganja zaradi sevanja manjša od tveganj bolezni same.
These medicines can then be used in medical procedures to carry radioactivity to where it is needed in the body such as sites of tumour cells. 
Ta zdravila je nato mogoče uporabiti v medicinskih postopkih za prenašanje radioaktivnosti v tiste dele telesa, kjer jo potrebujemo, npr. na mesta tumorskih celic.
It will only be administered as a combination. 
Dan bo le v kombinaciji.