natgillin/translations-raw huggingface dataset:
Physicians are recommended to follow current national and/or international consensus documents regarding the treatment of anthrax. 
Zdravniki naj upoštevajo veljavne nacionalne in/ali mednarodne dokumente o soglasju glede zdravljenja antraksa.
The plasma protein binding of ciprofloxacin is situated between 16% and 28% and is not dependent on the concentration and pH (determined by means of ultrafiltration). 
Vezava ciprofloksacina na beljakovine v plazmi je med 16 in 28 % ter ni odvisna od koncentracije in pH (določeno z ultrafiltracijo).
Use only clear solutions and undamaged containers. 
Uporabite samo bistro raztopino in nepoškodovane vsebnike.
The above-mentioned substances are converted by a specific enzyme (CYP1A2). 
Zgoraj omenjene učinkovine presnavlja poseben encim (CYP1A2).
Teratogenic effects have not been observed in animal experimental research. 
V raziskavah na živalih niso ugotovili teratogenih učinkov.
When photosensibility occurs the treatment must be discontinued. 
Če se pojavi fotosenzibilnost, je treba zdravljenje prekiniti.
• increased skin sensitivity to sunlight or UV light. 
• Povečana občutljivost kože na sončno ali ultravijolično svetlobo.
An overdose of 12 g has been reported to lead to mild symptoms of toxicity. 
Poročali so o odmerku 12 g, ki je privedel do blagih simptomov zastrupitve.
The frequency of side effects is classified into the following categories: Very common in more than 1 in 10 patients 
Pogostnost neželenih učinkov je razvrščena v naslednje skupine: Zelo pogosti pri več kot 1 od 10 bolnikov
• cyclosporine (used to prevent rejection reactions after organ transplantations). 
• Ciklosporin (uporablja se za preprečevanje reakcij zavrnitve po presaditvi organov).
These reactions may occcur particularly when the infusion time is 30 minutes or less. 
Te reakcije se lahko pojavijo predvsem takrat, kadar je čas infundiranja 30 minut ali manj.
The MIC of the Bacillus anthrax strain that was applied in this study was 0.08 µg/ml. 
MIK za sev bakterije Bacillus anthrax, uporabljen v tej študiji, je bila 0,08 µg/ml.
If one of the above-mentioned situations is applicable to you, your doctor may decide to prescribe you another medicine or to adjust the dose of Ciprofloxacin Kabi or the other medicine. 
Če se kateri od zgoraj naštetih primerov nanaša na vas, se bo zdravnik morda odločil, da vam predpiše drugo zdravilo ali da vam prilagodi odmerek zdravila Ciprofloxacin Kabi ali drugega zdravila.
• allergic reactions after the first administration of this medicine. 
• Alergijske reakcije po prvi uporabi zdravila.
If you are older than 65 years your doctor may prescribe you a dose based on your kidney function and severity of disease. 
Če ste starejši od 65 let, vam bo zdravnik odmerek predpisal na podlagi delovanja ledvic in resnosti bolezni.
These reactions occur more frequently when the infusion time is 30 minutes or less. 
Te reakcije so pogostejše, če je čas infundiranja 30 minut ali manj.
You should avoid long exposure to strong sunlight, sunlamps or other sources of UV radiation. 
Izogibajte se dolgi izpostavljenosti močni sončni svetlobi, solarijem ali drugim virom ultravijoličnega sevanja.
As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable. 
Posvetujte se s strokovnjakom v primeru, ko lokalna prevalence rezistence to zahteva, če je vprašljiva uporabnost učinkovine pri vsaj nekaterih tipih okužb.
Medical practice in the treatment of complicated UTI's with ciprofloxacin has developed and changed since the time of first licensing in 1987 and the proposed dosing is in line with current medical practice (5) and supported by the published literature. 
Zdravstvena praksa zdravljenja zapletenih okužb sečil s ciprofloksacinom se je razvila in spremenila od tiste, ki je veljala v času prve podelitve licence leta 1987, predlagano odmerjanje pa je usklajeno s trenutno medicinsko prakso (5) in ga podpira tudi objavljena literatura.
Compatibility with these solutions has been proven in the dilution range of 1+1 and 1+4, corresponding to ciprofloxacin concentrations of 0.4 to 1 mg/ml. 
Združljivost s temi raztopinami so dokazali pri redčenju 1+1 in 1+4, kar ustreza koncentracijam ciprofloksacina 0,4 do 1 mg/ml.
These may be manifested as local skin reactions, which rapidly disappear after the infusion has been completed. 
Kažejo se lahko kot lokalne kožne reakcije, ki po koncu infundiranja hitro izginejo.
• certain lower respiratory tract infections including pneumonia 
• določenih okužbah spodnjih dihal vključno s pljučnico
Osteomyelitis: 
Osteomielitis:
Antiperistaltics are contraindicated. 
Antiperistaltiki so kontraindicirani.
very common common uncommon rare very rare, including isolated reports 
zelo pogosti pogosti občasni redki zelo redki, vključno s posameznimi primeri
The reconstituted solution is clear and colourless. 
Rekonstituirana raztopina je bistra in brezbarvna.
Average duration of treatment can be 4-6 weeks. 
Povprečno trajanje zdravljenja je 4 - 6 tednov.
Prior to initiation of therapy, bacteriological sensitivity tests should be conducted. 
Pred začetkom zdravljenja je treba opraviti bakteriološke teste občutljivosti.
With respect to the maximal dose, the applicant reviewed 6 clinical studies addressing the safety and efficacy of the proposed high dose ciprofloxacin treatment regimens in critically ill patients. 
Kar se tiče najvišjega odmerka, je vlagatelj pregledal 6 kliničnih raziskav, ki so preučevale varnost in učinkovitost predlaganih načinov zdravljenja z visokimi odmerki ciprofloksacina pri kritično bolnih bolnikih.
Unless compatibility is proven, the solution for infusion should always be administered separately (see also section 6.2). 
Če združljivost ni dokazana, je treba raztopino za injiciranje vedno uporabljati posebej (glejte tudi poglavje 6.2).
Medicines should not be disposed via wastewater or household waste. 
Zdravila ne smete odvreči v odpadne vode ali med gospodinjske odpadke.
During the growth phase of bacteria, a partial rolling up and unfolding of chromosomes takes place. 
Med fazo bakterijske rasti pride do delnega zvitja in razvitja kromosomov.
See leaflet for further information. 
Glejte navodilo za uporabo za nadaljnje informacije.
• myastenia gravis (a particular type of muscle weakness). 
• Miastenija gravis (posebna vrsta mišične šibkosti).
From a microbiological point of view, the product should be used immediately. 
Zaradi možne mikrobiološke kontaminacije je treba raztopino uporabiti takoj.
OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF CIPROFLOXACIN KABI AND ASSOCIATED NAMES (see Annex I) 
SPLOŠNI POVZETEK ZNANSTVENEGA VREDNOTENJA ZDRAVILA CIPROFLOXACIN KABI IN Z NJIM POVEZANIH IMEN (glejte Dodatek I)
Therefore, the serum creatinine concentration must be checked regularly (twice per week) in these patients. 
Pri takšnih bolnikih je zato treba redno (dvakrat na teden) kontrolirati koncentracijo kreatinina.
Other information: 
Druge informacije:
Ciprofloxacin Kabi is an antibiotic. 
Ciprofloxacin Kabi je antibiotik.
Using other medicines If Ciprofloxacin Kabi and one of the following medicines are given at the same time, special care should be taken: 
Uporaba drugih zdravil Če se zdravilo Ciprofloxacin Kabi in eno od naslednjih zdravil uporabljata sočasno, je treba biti posebno previden:
Fresenius Kabi AB SE-75174 Uppsala Sweden 
Fresenius Kabi AB SE-75174 Uppsala Švedska
altered vision such as double vision (diplopia) and seeing all objects in a certain colour (chromatopsia) 
spremembe vida, npr. dvojni vid (diplopija) ali videnje vseh stvari v določeni barvi (kromatopsija)
In order to avoid treatment failure and emergence of resistance it is a prerequisite that patient's compliance and dosing need to be adequate. 
Da bi se izognili pojavu odpornosti in neuspehu pri zdravljenju, sta predpogoja za zdravljenje primerno sodelovanje bolnika in ustrezno odmerjanje.
Characteristics in patients: 
Značilnosti pri bolnikih:
• crystalluria (presence of crystals in the urine with discomfort when passing urine). 
• Kristalurija (prisotnost kristalov v urinu z neudobjem pri uriniranju).
In this case consult your doctor as your urine needs to be tested. 
V tem primeru se posvetujte z zdravnikom, saj je treba preiskati urin.
If these reactions recur or exacerbate during a following infusion no further infusions should be administered. 
Če se te reakcije ponovijo ali poslabšajo pri naslednjem infundiranju, se nadaljnjega infundiranja ne sme opraviti;
Signs of anaemia are a feeling of weakness and in more severe cases breathlessness and pale skin. 
Znaki anemije so občutek šibkosti in pri hujših primerih kratka sapa in bledica.
The enzyme DNA-gyrase plays a crucial role in this process. 
Ključno vlogo v tem dogajanju ima encim DNA-giraza.
All metabolites are active, but in a lesser degree than ciprofloxacin. 
Vsi presnovki so aktivni, vendar manj kot ciprofloksacin.
The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings. 
Trajanje zdravljenje je odvisno od resnosti okužbe, kliničnega odziva in bakterioloških raziskav.
If such reactions occur, a physician must immediately be consulted. 
Če se pojavijo takšne reakcije, se je treba takoj posvetovati z zdravnikom.
There is a linear correlation between dose on the one hand and plasma concentration and AUC on the other. 
Obstaja linearna korelacija med odmerkom na eni strani ter koncentracijo v plazmi in AUC na drugi strani.
In patients with severely impaired renal function (creatinine clearance <30 ml/min) the elimination half-life may be prolonged by a factor of 2. 
Pri bolnikih z zelo okvarjenim delovanjem ledvic (očistek kreatinina < 30 ml/min) je eliminacijski razpolovni čas lahko podaljšan za faktor 2.
Species for which acquired resistance may be a problem Gram-positive aerobes 
Vrste za katere je pridobljena rezistenca lahko problematična
The daily dose of 1200 mg should not however be exceeded. 
Vendar pa dnevni odmerek ne bi smel preseči 1200 mg.
Ciprofloxacin is mainly excreted unchanged. 
Ciprofloksacin se v glavnem izloči nespremenjen.
Central nervous system: 
Centralni živčni sistem:
If necessary, the oral anticoagulant dose should be adjusted as appropriate. 
Če je treba se odmerek antikoagulanta prilagodi po potrebi.
The treatment of acute pulmonary infections in children and adolescents with cystic fibrosis will take 10-14 days. 
Zdravljenje akutnih pljučnih okužb pri otrocih in mladostnikih s cistično fibrozo bo trajalo 10-14 dni.
Rare: photosensibility. 
Redki: fotosenzibilnost.
However the published data presented demonstrated the safety and efficacy of high-dose ciprofloxacin (daily dose of 1200 mg IV [or 1500 mg peroral]) with or without an option to oral switch, in various serious and life threatening infections. 
Kljub temu pa so predloženi podatki pokazali varnost in učinkovitost visokih odmerkov ciprofloksacina (dnevni odmerek 1200 mg intravensko [ali 1500 mg peroralno]) z ali brez možnosti prehoda na peroralno uporabo pri različnih resnih in življenjsko nevarnih okužbah.
This relatively high distribution volume indicates an effective tissue and fluid penetration. 
Sorazmerno velik volumen porazdelitve kaže na učinkovito prodiranje v tkiva in tekočine.
In case of mixed infections with anaerobes ciprofloxacin must be combined with other antibiotics effective against anaerobes. 
V primeru mešanih okužb z anaerobi je treba ciprofloksacin kombinirati z drugimi antibiotiki, učinkovitimi proti anaerobom.
Because the MIC90 for ciprofloxacin of 70 other Bacillus anthrax strains varied between 0.03-0.06 µg/ml, it seems likely that ciprofloxacin would also be effective in other strains than the one that was applied in this study. 
Ker je bila MIK90 ciprofloksacina za 70 drugih sevov bakterije Bacillus anthrax od 0,03 do 0,06 µg/ml, bi bil ciprofloksacin verjetno učinkovit tudi pri drugih sevih od tistega, ki je bil uporabljen v tej študiji.
The bioavailability is lower if antacids that contain aluminium and/or magnesium hydroxide, and calcium and iron salts are used concomitantly. 
Biološka uporabnost je manjša, če so sočasno uporabljeni antacidi, ki vsebujejo aluminijev in/ali magnezijev hidroksid, ali soli kalcija ali železa.
The undesirable effects sometimes occur already after the first administration of ciprofloxacin. 
Neželeni učinki se včasih pojavijo že po prvi uporabi ciprofloksacina.
They may take the form of local skin reactions, such as reddening of the skin, irritation or pain, which usually disappear quickly after termination of the infusion. 
Lahko se pojavijo v obliki lokalnih kožnih reakcij, kot so rdečica kože, razdraženost ali bolečina, ki navadno izginejo hitro po prenehanju infundiranja.
In case of very serious, life-threatening or recurrent infections the dosage can be increased to 400 mg three times daily. 
V primeru zelo resnih, smrtno nevarnih ali ponavljajočih se okužb, je mogoče odmerek zvišati na 400 mg trikrat na dan.
This has to be taken into consideration for patients on a controlled sodium diet. 
To je potrebno upoštevati pri bolnikih, ki so na dieti z malo natrija.
These side effects occur predominantly in patients at risk for certain heart disorders. 
Ti neželeni učinki se večinoma pojavijo pri bolnikih s tveganjem za nekatere srčne bolezni.
Rare: anxiety, nightmares, depression, hallucinations. 
Redki: anksioznost, nočne more, depresija, halucinacije.
• certain anti-inflammatory agents (e.g. ibuprofen, naproxen, but not acetylsalicylic acid), if ciprofloxacin is given in very high doses. 
• Nekatera protivnetna zdravila (npr. ibuprofen, naproksen, toda ne acetilsalicilna kislina), če se ciprofloksacin daje v zelo velikih odmerkih.
The maximum daily dose is 1200 mg. 
Največji dnevni odmerek je 1200 mg.
In this case you should immediately consult your doctor. 
V takem primeru se takoj posvetujte z zdravnikom.
For more details regarding some of the side effects please see Section 2, ‘Take special care with Ciprofloxacin Kabi- During or after treatment'. 
Za več informacij glede nekaterih neželenih učinkov glejte poglavje 2 »Bodite posebno pozorni pri uporabi zdravila Ciprofloxacin Kabi - med zdravljenjem ali po njem«.
Very rare: increment of amylase/lipase levels. 
Zelo redki: povišane vrednosti amilaze/lipaze.
There are however no sufficient clinical data available to draw conclusion about the effectiveness of ciprofloxacin in the treatment of anthrax in humans. 
Vendar pa ni na voljo dovolj kliničnih podatkov, da bi lahko sklepali o učinkovitosti ciprofloksacina za zdravljenje antraksa pri človeku.
Consideration should be given to official guidance on the appropriate use of antibacterial agents. 
Upoštevati je treba veljavne smernice glede ustrezne uporabe in predpisovanja antibiotikov.
To maintain the activity of the fluoroquinolone class, clinicians need to implement an evidence-based approach to antimicrobial selection, particularly a strategy in which the most pharmacodynamically potent fluoroquinolone is matched, on an empiric basis when required, to anticipated bacterial pathogens. 
Da bi ohranili aktivnost fluorokinolonov, morajo klinični zdravniki pri izbiri antimikrobiotikov uporabiti pristop, ki temelji na dokazih, zlasti pa strategijo, pri kateri se za pričakovane bakterijske patogene uporabi, po potrebi tudi na empirični osnovi, farmakodinamično najbolj močan fluorokinolon.
In this case you should immediately consult your doctor, since you may have a severe inflammation of the large intestine (pseudo membranous colitis). 
V takem primeru se takoj posvetujte z zdravnikom, saj imate lahko hudo vnetje debelega črevesa (psevdomembranski kolitis).
Mechanism of resistance: 
Mehanizem rezistence:
Patients receiving ciprofloxacin should be well hydrated and excessive alkalinity of the urine should be avoided. 
Bolniki, ki prejemajo ciprofloksacin morajo biti dobro hidrirani in potrebno se je izogibati prekomerno alkalnemu urinu.
As a result of its mechanism of action, ciprofloxacin does not show cross-resistance with other important, chemically different groups of substances such as beta-lactam antibiotics, aminoglycosides, tetracyclines, macrolides and polypeptides, sulphonamides, trimethoprim and nitrofurantoine. 
Zaradi svojega mehanizma delovanja ciprofloksacin ne kaže navzkrižne odpornosti z drugimi pomembnimi, kemično drugačnimi skupinami snovi, npr. betalaktamskimi antibiotiki, aminoglikozidi, tetraciklini, makrolidi in polipeptidi, sulfonamidi, trimetoprimom in nitrofurantoinom.
If exposure to sunlight or UV light is inevitable you should use sun cream to protect yourself. 
• Če je izpostavljenost sončni ali ultravijolični svetlobi neizogibna, za zaščito uporabite kremo za sončenje.
• feeling depressed or confused after administration of Ciprofloxacin Kabi. 
• Občutek depresije ali zmedenosti po jemanju zdravila Ciprofloxacin Kabi.
Evidence is mounting that suggests a link between inappropriate fluoroquinolone use, development of antimicrobial resistance against the entire fluoroquinolone class, and clinical failure. 
Vse več je dokazov, ki nakazujejo na povezavo med neprimerno uporabo fluorokinolona, razvojem odpornosti mikroorganizmov na celoten razred fluorokinolonov in neuspehom kliničnega zdravljenja.
Paediatric patients: 
Pediatrični bolniki:
ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTHS OF THE MEDICINAL PRODUCTS, ROUTE OF ADMINISTRATION, APPLICANTS MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES 
DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE, PREDLAGATELJEV, IMETNIKOV DOVOLJENJA ZA PROMET V DRŽAVAH ČLANICAH
Anaphylactic/anaphylactoid reactions can in very rare cases develop into life-threatening shock, sometimes even after the first administration of ciprofloxacin. 
Anafilaktične/anafilaktoidne reakcije se lahko v zelo redkih primerih razvijejo v smrtno nevaren šok, včasih celo že po prvi uporabi ciprofloksacina.
If you use one of these medicines together with ciprofloxacin you will be monitored for signs of overdose. 
Če katerega od teh zdravil jemljete sočasno s ciprofloksacinom, vas bodo spremljali za znake prevelikega odmerjanja.
As with all other antibiotics, the patient should be monitored during therapy for the development of resistant strains of initially sensitive bacteria, especially P. aeruginosa and S. aureus (see the relevant statements in section 5.1). 
Tako kot pri zdravljenju z drugimi antibiotiki je treba bolnika med terapijo nadzirati glede pojava odpornih sevov uvodoma občutljivih bakterij, zlasti P. aeruginosa in S. aureus (glejte zadevne navedbe v poglavju 5.1).
Generally, acute and chronic infections (e.g. osteomyelitis and prostatitis, etc), where the causative organism is known to be sensitive to ciprofloxacin, should be treated for at least three days after the signs and symptoms of the infection have disappeared. 
Za akutne in kronične okužbe (tj. osteomielitis in prostatitis, itd.), kjer je znano, da je povzročitelj občutljiv za ciprofloksacin, splošno velja, da jih je treba zdravljenje nadaljevati najmanj tri dni po izginotju znakov in simptomov okužb.
A study on Rhesus-monkeys that were exposed to anthrax by inhalation revealed that 8/9 animals survived the experiment when these animals were treated from 1 day after anthrax exposure with ciprofloxacin twice daily for a period of 30 days. 
Študija na opicah Rhesus, izpostavljenih vdihanemu antraksu, je pokazala, da je 8 od 9 živalih poskus preživelo, če so te živali od 1. dne po izpostavljenosti antraksu zdravili s ciprofloksacinom dvakrat na dan 30 dni.
Unless compatibility is proven, the solution for infusion should always be administered separately. 
Če združljivost ni dokazana, je treba raztopino za injiciranje vedno uporabljati posebej.
In acute and extreme overdosage, reversible kidney damage is seen. 
Pri akutnem in skrajno prevelikem odmerjanju so opazili reverzibilno poškodbo ledvic.
- The applicant submitted in addition to the proposed Summary of Product Characteristics, a proposal for harmonised labelling and package leaflet. 
- Vlagatelj je poleg predloga Povzetka glavnih značilnosti zdravila predložil tudi predlog za usklajeno označevanje in Navodila za uporabo.
Management of patients with complicated urinary tract infections (UTIs) currently includes empirical treatment with a broad-spectrum antibiotic (fluoroquinolone), and potential subsequent treatment for 10-14 days based on urine culture and sensitivity. 
Zdravljenje bolnikov z zapletenimi okužbami sečil trenutno obsega empirično zdravljenje z antibiotikom širokega spektra (fluorokinolon) in morebitno naknadno, 10 do 14 dni trajajoče zdravljenje, ki je odvisno od urinske kulture ter občutljivosti.
* MRSA are very likely to be resistant to ciprofloxacin and ciprofloxacin should not be used to treat presumed or known MRSA infections unless the organism is known to be susceptible. 
*Obstaja velika verjetnost, da je MRSA rezistentna na ciprofloksacin in ciprofloksacin se ne sme uporabljati za zdravljenje domnevnih ali znanih okužb z MRSA razen če je mikroorganizem ocenjen za občutljivega.
The renal clearance occurs through glomerular filtration and active tubular secretion. 
Ledvični očistek poteka z glomerulno filtracijo in aktivno tubulnosekrecijo.
The dosage in children with impaired renal and/or hepatic function has not been investigated. 
Odmerjanje pri otrocih z okvarjenim delovanjem ledvic in/ali jeter ni raziskano.
• Do not refrigerate or freeze. 
• Ne shranjujte v hladilniku ali zamrzujte.
Most frequent side effects affect the stomach and intestine, the nervous system and the skin and connective tissue. 
Najpogostejši neželeni učinki prizadenejo želodec in črevo, živčni sistem in kožo ter vezivno tkivo.
• severe and continuous diarrhoea during treatment, possibly with blood and mucus. 
• Huda in trajajoča driska med zdravljenjem, lahko s krvjo ali sluzjo.
• methotrexate (used to treat cancer or suppress the immune system). 
• Metotreksat (za zdravljenje raka ali zaviranje imunskega sistema).
This may increase the effect of glibenclamide (too low blood sugar level). 
To lahko poveča učinek glibenklamida (prenizka koncentracija sladkorja v krvi);
Animal trials have shown that the concurrent administration of very high doses of fluoroquinolones and certain NSAIDs (but not acetylsalicylic acid) may provoke convulsions. 
Poskusi na živalih so pokazali, da lahko sočasna uporaba zelo velikih odmerkov fluorokinolonov in nekaterih nesteroidnih protivnetnih zdravil (vendar ne acetilsalicilne kisline) povzroči konvulzije.
Impaired hepatic function: In case of impaired hepatic function it is not necessary to adjust the dosage. 
Okvarjeno delovanje jeter: V primeru okvarjenega delovanja jeter odmerka ni potrebno prilagoditi.
No data was presented comparing the efficacy, safety or prevention of bacterial resistance using the 800mg maximum IV dose licensed in the UK and the 1200mg IV ciprofloxacin proposed by the applicant. 
Vlagatelj ni predstavil podatkov, ki bi primerjali učinkovitost, varnost ali preprečevanje odpornosti bakterij pri 800 mg največjem intravenskem odmerku, ki so ga odobrili v Združenem kraljestvu, in 1200 mg ciprofloksacina intravensko, ki ga je predlagal vlagatelj.
Ciprofloxacin Kabi cannot be mixed with solutions that are not stable at a pH of approximately 4. 
Ciprofloxacina Kabi ne smemo mešati z raztopinami, ki niso stabilne pri pH približno 4.
• known allergic reaction to ciprofloxacin or any of the other ingredients of Ciprofloxacin Kabi or other medicines of the quinolone type 
• znana alergijska reakcija na ciprofloksacin ali katero koli sestavino zdravila Ciprofloxacin Kabi ali druga zdravila iz skupine kinolonov,
When undesirable effects on the central nervous system, like dizziness, occur, it is prohibited to drive a vehicle or to operate machines. 
Če se pojavijo neželeni učinki na osrednje živčevje, npr. omotica, bolnik ne sme voziti ali upravljati s stroji.
The peak plasma concentration is reached 0.5 - 2 hours after taking 50 - 1000 mg p.o. and varies from 0.3 - 5.9 mg/l. 
Največjo koncentracijo v plazmi doseže od 0,5 do 2 uri po peroralni uporabi od 50 do 1000 mg in sega od 0,3 do 5,9 mg/l.