natgillin/translations-raw huggingface dataset:
Each spray delivers 27.5 micrograms of fluticasone furoate. 
Pri enem vpihu se sprosti 27,5 mikrogramov flutikazonfuroata.
It is best to store your Avamys nasal spray upright. 
Pršilo za nos Avamys je najbolje shranjevati v pokončnem položaju.
- If you get any side effects, talk to your doctor or pharmacist or nurse. 
- Če opazite katerikoli neželeni učinek, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
Very rare side effects (may affect up to 1 in 10,000 people) • Small holes (perforations) in the ridge inside the nose that separates the nostrils. 
• majhne luknjice (perforacije) v nosni pregradi, ki ločuje nosnici.
There are no data with intranasal fluticasone furoate in patients with hepatic impairment. 
Pri bolnikih z okvaro jeter ni podatkov o nazalni uporabi flutikazonfuroata.
Avamys nasal spray is for administration by the intranasal route only. 
Pršilo za nos Avamys je namenjeno le za nazalno uporabo.
If you get any side effects talk to your doctor, pharmacist or nurse. 
Če opazite katerikoli neželeni učinek, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
Once adequate control of symptoms is achieved, dose reduction to one spray actuation in each nostril (total daily dose 55 micrograms) may be effective for maintenance. 
Ko je dosežen zadosten nadzor simptomov, je zdravljenje možno vzdrževati že z enim vpihom v vsako nosnico (skupni dnevni odmerek 55 mikrogramov).
Avamys 27.5 micrograms/spray nasal spray suspension Fluticasone furoate 
Avamys 27,5 mikrogramov/vpih pršilo za nos, suspenzija flutikazonfuroat
Fluticasone furoate nasal spray 110 micrograms once daily significantly improved nasal symptoms as well as patients' perception of overall response to therapy compared to placebo in three studies. 
Celoletni alergijski rinitis pri odraslih in mladostnikih V primerjavi s placebom je flutikazonfuroat v obliki pršila za nos v odmerku 110 mikrogramov enkrat na dan v vseh treh študijah pomembno izboljšal tako nosne simptome kot tudi bolnikov vtis o celotnem odzivu na zdravljenje.
Avamys 27.5 micrograms per spray nasal spray suspension Fluticasone furoate 
Avamys 27, 5 mikrogramov na vpih pršilo za nos, suspenzija flutikazonfuroat
In perennial allergic rhinitis, fluticasone furoate nasal spray 55 micrograms once daily exhibited a more consistent efficacy profile than fluticasone furoate nasal spray 110 micrograms once daily over 4 weeks' treatment. 
Pri celoletnem alergijskem rinitisu je bil v času 4-tedenskega zdravljenja profil učinkovitosti flutikazonfuroata v obliki pršila za nos v odmerku 55 mikrogramov enkrat na dan doslednejši kot pri uporabi flutikazonfuroata v obliki pršila za nos v odmerku 110 mikrogramov enkrat na dan. Post hoc analiza po 6 in 12 tednih v isti študiji, kot tudi 6-tedenska študija varnosti osi hipotalamus-hipofizanadledvični žlezi, podpirata učinkovitost flutikazonfuroata v obliki pršila za nos v odmerku 110 mikrogramov enkrat na dan.
You must prepare the nasal spray: 
Pršilo za nos morate pripraviti:
AVAMYS 27.5 micrograms/spray, nasal spray suspension 
AVAMYS 27,5 mikrogramov/vpih pršilo za nos, suspenzija
Renal Impairment No dose adjustment is required in this population (see section 5.2). 
Okvara ledvic Pri bolnikih z okvaro ledvic odmerka ni treba prilagajati (glejte poglavje 5.2).
Growth retardation has been reported in children receiving nasal corticosteroids. 
Pri otrocih, ki so prejemali nazalne kortikosteroide, je bil opisan zaostanek v rasti.
Distribution 
Porazdelitev:
In the majority of patients fluticasone furoate is not quantifiable (< 10 pg/ml) following intranasal dosing of 110 micrograms once daily. 
Po nazalnem odmerku 110 mikrogramov enkrat na dan flutikazonfuroata pri večini bolnikov ni možno meriti (< 10 pg/ml).
The intranasal device should be shaken before use. 
Pred uporabo je treba pršilnik dobro pretresti.
There was no evidence for higher quantifiable levels of fluticasone furoate in younger children (less than 6 years of age). 
Pri mlajših otrocih (mlajših od 6 let) niso poročali o višjih merljivih vrednostih flutikazonfuroata.
Onset of action has been observed as early as 8 hours after initial administration. 
Začetek delovanja so opazili že 8 ur po prvi uporabi, vendar pa se največja korist lahko pokaže šele nekaj dni po začetku zdravljenja.
Growth retardation has been reported in children receiving nasal corticosteroids at licensed doses. 
Pri otrocih, ki so se zdravili s priporočenimi odmerki nazalnih kortikosteroidov, so poročali o zaostanku v rasti.
Nasal use. 
nazalna uporaba
There is a step-by-step guide to using the nasal spray after Section 6 of this leaflet. 
Na koncu poglavja 6 tega besedila je podrobno navodilo za uporabo pršila za nos.
Hepatic impairment 
Bolezni živčevja Pogosti glavobol
Glucose anhydrous Dispersible cellulose Polysorbate 80 
6.1 Seznam pomožnih snovi brezvodna glukoza disperzibilna celuloza polisorbat 80 benzalkonijev klorid dinatrijev edetat prečiščena voda
Each spray actuation delivers 27.5 micrograms of fluticasone furoate. 
KAKOVOSTNA IN KOLIČINSKA SESTAVA Pri enem vpihu se sprosti 27,5 mikrogramov flutikazonfuroata.
Reporting of side effects 
Poročanje neželenih učinkov
Uncommon side effects (may affect up to 1 in 100 people) • Pain, burning, irritation, soreness or dryness in the inside of the nose. 
• bolečina, pekoč občutek, draženje, bolečnost ali suhost v notranjosti nosu.
How to store Avamys 
Shranjevanje zdravila Avamys
Rhinalgia, nasal discomfort (including nasal burning, nasal irritation, and nasal soreness), nasal dryness. 
Občasni rinalgija, težave v nosu (vključno s pekočim občutkom v nosu, draženjem nosu in bolečnostjo nosu), suhost nosu
How much to use 
Način uporabe
Laboratoire GlaxoSmithKline Tél. 
France Laboratoire GlaxoSmithKline
• Always keep the cap on the nasal spray when you are not using it. 
• Kadar pršila za nos ne uporabljate, naj bo na njem vedno nameščen pokrovček.
It may harm them, even if their signs of illness seem the same as yours. 
Njim bi lahko celo škodovalo, čeprav imajo znake bolezni, podobne vašim.
STEP-BY-STEP GUIDE TO USING THE NASAL SPRAY 
NAVODILO ZA UPORABO PRŠILA ZA NOS
What Avamys contains The active substance is fluticasone furoate. 
Zdravilna učinkovina je flutikazonfuroat.
It will damage the nasal spray 
S tem boste namreč poškodovali pršilo za nos.
Invented name Pharmaceutical form 
Izmišljeno ime Farmacevtska oblika
The study was not considered further as it contained insufficient detail. 
Ta študija se ni dodatno obravnavala, ker je vsebovala premalo podrobnosti.
OVERALL SUMMARY OF THE SCIENTIFIC CONCLUSIONS 1. 
SPLOŠNI POVZETEK ZNANSTVENIH ZAKLJUČKOV 1.
All validity criteria of the guideline were fulfilled. 
Izpolnjena so bila vsa merila veljavnosti iz smernice.
It is not clear to what extent a population recovery may have occurred at the end of the test period. 
Ni jasno, v kakšnem obsegu je do konca preskusa lahko prišlo do obnovitve populacije.
The difference in DT50 and DT90 values are relative small. 
Razlike med vrednostmi DT50 in DT90 so sorazmerno majhne.
Only two data points are available, i.e. the start and end of the study, where unfortunately no precise level of concentration recovery was reported (less than 20%). 
Na voljo sta samo dve podatkovni točki, tj. začetek in konec študije brez navedbe točnega izkoristka koncentracij (manj od 20 %).
2.3.4 Microorganisms 
2.3.4 Mikroorganizmi
The number and variation in the soil types are considered acceptable. 
Število vrst zemlje in razlike med njimi se štejejo za sprejemljive.
GROUNDS FOR RECOMMENDATION OF THE GRANTING OF A MARKETING AUTHORISATION 
PODLAGA ZA PRIPOROČILO ODOBRITVE DOVOLJENJA ZA PROMET Z ZDRAVILOM
Assessment of the environmental risk 
Ocena tveganja za okolje
This is a major reason why the EU (EMEA/CVMP) has made the testing of cyanobacteria mandatory for all antibiotics. 
To je glavni razlog, da je EU (EMEA/CVMP) za vse antibiotike uvedla obvezno preskušanje na cianobakterijah.
11-12 Pol. Ind. La Borda 08140 Caldes de Montbui SPAIN 
La Borda 08140 Caldes de Montbui ŠPANIJA
The growth rates are unlikely to have been exponential, and therefore the tests are likely to have been conducted under sub-optimal sensitivity. 
Hitrosti rasti verjetno niso bile eksponentne, zato so bili preskusi verjetno opravljeni z občutljivostjo, ki je pod optimalno.
The correlation between measured parameters and dry weight of biomass should have been reported. 
Moralo bi se navesti ujemanje med izmerjenimi parametri in suho maso biomase.
ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTH OF THE VETERINARY MEDICINAL PRODUCT, ANIMAL SPECIES, ROUTE OF ADMINISTRATION, APPLICANT IN THE MEMBER STATES 
DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVIL ZA UPORABO V VETERINARSKI MEDICINI, ŽIVALSKIH VRST, POTI UPORABE IN PREDLAGATELJEV V DRŽAVAH ČLANICAH
The soil characteristics and resulting DT50 and DT90 values were: DT50: 141, 103, 99 and 149 days; DT90: 469, 342, 330 and 495 days. 
Pridobljene vrednosti DT50 in DT90, ki so značilne za prst, so bile: DT50: 141, 103, 99 in 149 dni; DT90: 469, 342, 330 in 495 dni.
If a less conservative approach is taken, the geometric mean of the four DT50 values could be used, i.e. 121 days. 
Če izberemo manj konzervativen pristop, lahko uporabimo geometrično povprečje štirih vrednosti DT50, tj. 121 dni.
The valid Summary of Product Characteristics, labelling and package leaflet are the final versions achieved during the Coordination group procedure. 
Veljavni povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo so končne različice, dogovorjene med postopkom Usklajevalne skupine.
With the existing disappearance data it would be necessary to use a time-weighted-average approach. 
Z obstoječimi podatki o razgradnji je treba uporabiti pristop tehtanega povprečja v določenem časovnem intervalu.
Antibiotics are likely to be toxic to algae and cyanobacteria. 
Antibiotiki so verjetno toksični za alge in cianobakterije.
No further consideration is made to the data of the green algae as this was more than 50 times less sensitive to enrofloxacin. 
Podatki za zelene alge se nadalje niso obravnavali, saj so te več kot 50-krat manj občutljive na enrofloksacin.
The calculations for the minor species turkeys were not considered further in this referral as the risk in any case will be lower. 
Izračuni za purane kot skupine MUMS se v tem napotitvenem postopku niso obravnavali, saj bo tveganje v vsakem primeru manjše.
The Committee recognised that the design of the study had deficiencies but agreed that the results can be used for the PEC calculations. 
Odbor priznava, da ima zasnova študije napake, vendar se strinja, da se lahko rezultati uporabijo za izračune PKO.
The Koc was calculated as 110,885 l kg/1(geometric mean). 
Izračunali so Koc 110 885 l kg/1(geometrično povprečje).
The product is intended to be used for the treatment of diseases of the respiratory and alimentary tracts of bacterial or mycoplasmal origin in chickens and turkeys. 
Zdravilo je namenjeno zdravljenju bolezni dihal in prebavil, ki jih povzročijo bakterije ali mikoplazme pri kokoših in puranih.
The study by Robinson et al 2005 is, overall, a well reported scientific paper, which has been published in a well established international peer reviewed Journal. 
Študija Robinsona et al. (2005) je na splošno dobro napisan znanstveni prispevek, ki je bil objavljen v dobro uveljavljeni mednarodni recenzirani reviji.
A comprehensive set of data needed to conduct an environmental risk assessment according to the VICH and CVMP guidelines was provided. 
Predložen je bil obsežen niz podatkov, ki so potrebni za ocene tveganja za okolje v skladu s smernicami VICH in CVMP.
The submitted environmental risk assessment report is based on new studies initiated by the applicant and on bibliographical data extracted from peer reviewed journals. 
Predloženo poročilo ocene tveganja za okolje temelji na novih študijah, ki jih je začel predlagatelj izvajati, ter na bibliografskih podatkih iz recenziranih revij.
The EC50 values for M. aeruginosa and P. subcapitata were 49 and 3,100 µg/l, respectively. 
Vrednost EC50 za M. aeruginosa je bila 49, za P. subcapitata pa 3,100 µg/l.
Risk characterisation is calculated from the risk quotient (RQ), which should be less than 1 in all taxonomic levels to consider that enrofloxacin does not represent a risk to the environment. 
Opis tveganja se izračuna iz količnika tveganja (KT), ki mora biti nižji od 1 za vse taksonomske ravni, da se šteje, da enrofloksacin ne pomeni tveganja za okolje.
The geometric mean of these two EC50 values is 15.9 µg/l. 
Geometrično povprečje teh dveh vrednosti EC50 je 15,9 µg/l.
Other data are taken from peer reviewed articles published in the open literature. 
Drugi podatki so bili vzeti iz recenziranih člankov, objavljenih v dostopni literaturi.
If one assumes a worst case situation, then the highest DT50 should be used for further assessment (e.g. PECSoil-plateau calculations). 
Če si predstavljamo najslabšo situacijo, lahko za nadaljnjo oceno (npr. izračun PKOzemlja-plato) uporabimo največjo vrednost DT50.
In particular the adequacy of the data provided in respect to the environmental risk assessment regarding these two points was questioned. 
Predvsem je obstajal dvom glede zadostnosti podatkov, predloženih pri oceni tveganja za okolje.
The seeds were placed in a natural sandy soil containing the test item at nominal concentrations of 10, 31.6, 100, 316 and 1000 mg enrofloxacin/kg dry soil (cucumber, lettuce, mung bean, oat and wheat) and 3, 12, 48, 192 and 768 mg enrofloxacin/kg dry soil (rye), respectively. 
Semena so položili v naravno peščeno zemljo, ki je vsebovala preskušano snov v nazivnih koncentracijah 10, 31,6, 100, 316 in 1 000 mg enrofloksacina/kg suhe prsti (kumara, zelena solata, fižol, oves in pšenica) oziroma 3, 12, 48, 192 in 768 mg enrofloksacina/kg suhe zemlje(rž).
Application of the CVMP guideline Environmental Impact Assessment for Veterinary Medicinal Products in support of the VICH guidelines GL6 and GL38 results in an estimate of PECsurfacewater of 0.019 µg/l. 
Z uporabo smernice CVMP za oceno vpliva zdravil za uporabo v veterinarski medicini na okolje ob smernicah VICH GL6 in GL38 dobimo oceno PKOpovršinska voda 0,019 µg/l.
A conservative PNEC value could hence be established at 10 µg/l. 
Lahko se določi konzervativna vrednost PKBU 10 µg/l.
The disappearance of non-labelled enrofloxacin was investigated according to OECD guideline 307 in four soils with different content of organic carbon and clay and pH values. 
Razpadanje neoznačenega enrofloksacina so preiskali skladno s smernico OECD 307 v štirih vzorcih zemlje z različno vsebnostjo organskega ogljika in gline ter različnimi vrednostmi pH.
Given the uncertainty of the fate and disappearance of enrofloxacin during the course of the test, the CVMP cannot support using the nominal concentrations for the establishment of EC50 values. 
CVMP glede na negotovost usode in razgradnjo enrofloksacina med preskusom ne more podpreti uporabe nazivnih koncentracij za določitev vrednosti EC50.
For the treatment of salmonellosis treatment should be extended to 5 days. 
Zdravljenje salmoneloze naj se podaljša na
The following test species were used: Cucumis sativus (cucumber), Lactuca sativa (lettuce), Phaseolus aureus (mung bean), Avena sativa (oat), Triticum aestivum (wheat) and Secale cereale (rye). 
Uporabili so naslednje preskusne vrste: Cucumis sativus (kumara), Lactuca sativa (zelena solata), Phaseolus aureus (fižol), Avena sativa (oves), Triticum aestivum (pšenica) in Secale cereale (rž).
The CVMP agrees that the applicant has met all the requirements for the plant toxicity evaluation, i.e. new toxicity data and the use of the PECsoil-plateau based on new degradation studies. 
CVMP se strinja, da je predlagatelj izpolnil vse zahteve za vrednotenje toksičnosti za rastline, tj. nove podatke o toksičnosti in uporabo vrednosti PKOzemlja-plato na podlagi novih študij razkroja.
Enro-K 10% Oral Solution contains 100 mg enrofloxacin as active ingredient per 1 ml product. 
Enro-K 10 % peroralna raztopina vsebuje 100 mg enrofloksacina kot zdravilne učinkovine na 1 ml zdravila.
As ciprofloxacin represents only 2% of the total outcome of the enrofloxacin metabolism in chickens it is assumed that any potential risk of metabolites is encompassed by using the total residue approach assuming that the total dose is excreted as parent compound or as metabolites with a toxicity that is similar to the parent compound. 
Ker predstavlja ciprofloksacin le 2 % skupne presnove enrofloksacina pri kokoših, se šteje, da so vsa možna tveganja presnovkov zajeta s pristopom vseh ostankov pri predpostavki, da se celotni odmerek izloči kot izhodna spojina ali kot presnovki s toksičnostjo, podobno izhodni spojini.
The applicant provided an environmental risk assessment for Enro-K 10% Oral Solution that followed in general the established guidelines and recommendations. 
Predlagatelj je predložil oceno tveganja zdravila Enro-K 10 % peroralna raztopina za okolje, v katerem je na splošno upošteval uveljavljene smernice in priporočila.
The CVMP concludes from the new studies provided that the applicant has met the requirements for the plant toxicity evaluation. 
CVMP na podlagi predloženih novih študij zaključi, da je predlagatelj izpolnil zahteve za vrednotenje toksičnosti za rastline.
For all species tested a clear concentration dependent effect occurred and EC50 and NOEC values were found in the range of 124 to 435 and less than 10 to 100 mg/kg, respectively. 
Pri vseh preskušanih vrstah se je pojavil jasen, od koncentracije odvisen učinek, vrednost EC50 je bila določena v razponu od 124 do 435 mg/kg, vrednost NOEC pa v razponu od manj kot 10 do 100 mg/kg.
From this data it can be concluded that there would be no risk at environmental concentrations 10 times the PECsoil value established above (542.9 µg/kg). 
Iz teh podatkov je mogoče zaključiti, da pri okoljskih koncentracijah 10-kratnika zgoraj določene vrednosti PKOprst (542,9 µg/kg) tveganja ni.
A study taken from the open literature, Knapp et al (2005)4, indicated that exposure is very low. 
Študija Knapp et al. (2005)4iz dostopne literature kaže, da je izpostavljenost zelo majhna.
The EC50 for nitrogen transformation was estimated to be above 29 mg/kg soil. 
Vrednost EC50 za preobrazbo dušika je bila ocenjena na nad 29 mg/kg prsti.
However, the data for the test on cyanobacteria Microcystis aeruginosa does not meet validity criteria required in OECD guideline 201. 
Vendar podatki preskusa na cianobakteriji Microcystis aeruginosa ne izpolnjujejo meril veljavnosti, ki jih predpisuje smernica OECD 201, saj ni prikazan koeficient variacije (KV).
Enro-K 10% Oral Solution 
Enro-K 10 % peroralna raztopina Peroralna raztopina
Using the current guidelines the calculated PECsoil-plateau is 542.9 µg/kg. 
Če uporabimo trenutne smernice, je izračunana vrednost PKOzemlja-plato 542,9 µg/kg.
During the decentralised procedure concerns were raised that Enro-K 10% Oral Solution may present a potential serious risk to the environment regarding risk to blue-green algae and to terrestrial plants. 
Med decentraliziranim postopkom so se pojavili zadržki, da bi lahko zdravilo Enro-K 10 % peroralna raztopina lahko pomenila resno tveganje za okolje glede na modrozelene alge in kopenske rastline.
A study, taken from the open literature, Boxall et al (2006)3, was also provided. 
Predložena je bila tudi študija Boxalla et al. (2006)3 iz dostopne literature.
The effect of enrofloxacin on nitrogen transformation by soil organisms was investigated according to OECD guidelines 216 and EU Test Method C.21. 
Učinek enrofloksacina na preobrazbo dušika z organizmi v zemlji so raziskali v skladu s smernico OECD 216 in preskusno metodo EU C.21.
The CVMP therefore concludes that the objections raised by Germany should not prevent the granting of a Marketing Authorisation and that the dossier as submitted in the referral procedure fulfils the necessary requirements with regards to the risk assessment for cyanobacteria (blue-green algae) and terrestrial plants. 
CVMP zato meni, da zadržki, ki jih je sprožila Nemčija, ne smejo preprečiti odobritve dovoljenja za promet z zdravilom ter da dokumentacija, predložena v napotitvenem postopku, izpolnjuje potrebne zahteve glede ocene tveganja za cianobakterije (modrozelene alge) ter kopenske rastline.
The proposed NOEC values are acceptable and can be used to derive a PNEC value of 100 mg/kg (100,000 µg/kg). 
Predlagane vrednosti NOEC so sprejemljive in se lahko uporabijo za določitev vrednosti PKBU 100 mg/kg (100 000 µg/kg).
Consequently no risk quotient (PEC/PNEC) is derived for cyanobacteria. 
Posledično za cianobakterije ni izpeljanega količnika tveganja (PKO/PKBU).
Overall, the CVMP agreed that enrofloxacin is unlikely to pose any significant risk to ground water. 
Na splošno se CVMP strinja, da enrofloksacin verjetno ne predstavlja bistvenega tveganja za podtalnico.
The Phase I environmental risk assessment following the VICH guideline results in Predicted Environmental Concentrations (PECs) in soil for Enro-K 10% Oral Solution for broiler chickens (10 mg/kg bw/day, for 5 days) above 100 µg/kg, thus requiring a Phase II assessment. 
V I. fazi ocene tveganja za okolje na podlagi smernic VICH so dobljene koncentracije v okolju (PKO) v prsti za zdravilo Enro-K 10 %, peroralna raztopina, pri brojlerjih (10 mg/kg telesne mase /dan, 5 dni) nad 100 µg/kg, kar pomeni, da je potrebna ocena faze II.
Rye was the most sensitive species, with an EC50 of 124 mg/kg. 
Najobčutljivejša vrsta je bila rž z vrednostjo EC50 124 mg/kg.
The geometric mean concentration during exposure was used to estimate a more realistic effect-measure compared to the nominal concentrations as also suggested in OECD 201. 
Za bolj realno oceno mere učinka v primerjavi z nazivnimi koncentracijami je bilo uporabljeno geometrično povprečje koncentracij med izpostavljenostjo, kar priporoča tudi OECD 201.
2.3.Effect studies and calculation of PNEC values 
Študije učinka in izračun vrednosti PKBU
The NOEC for the tested loamy sand field soil was found to be 2.9 mg enrofloxacin per kg soil (dry mass). 
Vrednost NOEC za preskušano zemljo iz ilovnatega peska je bila 2,9 mg enrofloksacina na kg prsti (suha masa).
The application of an assessment factor of 100 leads to a PNEC value of 0.49 µg/l for algae. 
Če uporabimo faktor ocenjevanja 100, dobimo vrednost PKBU za alge 0,49 µg/l.
The proposed EC50 values are acceptable and can be used to derive a PNEC value of 1.24 mg/kg (1240 µg/kg). 
Predlagane vrednosti EC50 so sprejemljive in se lahko uporabijo za določitev vrednosti PKBU 1,24 mg/kg (1 240 µg/kg).
If the geometric mean of DT50 values from the four soils is used, the PECsoil-plateau is 506 µg/kg. 
Če uporabimo geometrično povprečje vrednosti DT50 štirih prsti, je PKOprst-plato 506 µg/kg.
2.1.2 Soil adsorption and desorption A study, published in the peer-reviewed and open literature (Nowara et al 1997)1 indicated that enrofloxacin and other fluoroquinolones are strongly adsorbed to soils with high content in clay minerals of montmorillonite and kaolinite, basically through electrostatic interactions between ionized carboxylated groups of fluoroquinolones and exchangeable cations within clay layers. 
V študiji, ki je bila objavljena v recenzirani in dostopni literaturi (Nowara et al 1997)1, ugotavljajo, da se enrofloksacin in drugi fluorokinoloni močno vežejo na zemljo z visoko vsebnostjo glinenih mineralov montmorilonita in kaolinita, predvsem z elektrostatskimi interakcijami med ioniziranimi karboksiliranimi skupinami fluorokinolonov ter zamenljivimi kationi v glinenih plasteh.
The coefficient of variation (CoV) was not provided, however the relatively narrow span of the 95% confidence interval around the estimated EC50 values qualitatively indicates an acceptable variation in data. 
Kljub temu sorazmerno ozek razpon 95-odstotnega intervala zaupanja okoli ocenjene vrednosti EC50 kvalitativno kaže na sprejemljivo variabilnost podatkov.
Environmental fate studies 
Študije usode v okolju
There was no concentration dependent effect on seedling emergence due to enrofloxacin up to the highest concentration tested. 
Niso opazili od koncentracije enrofloksacina odvisnega učinka na kalitev semen do najvišje preskusne koncentracije.