natgillin/translations-raw huggingface dataset:
For the full list of side effects of Remicade, see the package leaflet. 
Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Remicade, glejte navodilo za uporabo.
Remicade contains the active substance infliximab. 
Zdravilo Remicade vsebuje učinkovino infliksimab.
• psoriasis (a disease causing red, scaly patches on the skin). 
• psoriazo (boleznijo, ki povzroča rdeče, luskaste zaplate na koži).
How is Remicade used? 
Kako se zdravilo Remicade uporablja?
• rheumatoid arthritis (an immune system disease causing inflammation of the joints). 
• revmatoidnim artritisom (boleznijo imunskega sistema, ki povzroča vnetje sklepov).
Remicade is given as an infusion lasting one or two hours. 
Zdravilo Remicade se daje v obliki eno- ali dvourne infuzije.
• ankylosing spondylitis (a disease causing inflammation and pain in the joints of the spine); 
• ankilozirajočim spondilitisom (boleznijo, ki povzroča vnetje in bolečine v sklepih v hrbtenici);
• psoriatic arthritis (a disease causing red, scaly patches on the skin and inflammation of the joints); 
• psoriatičnim artritisom (boleznijo, ki povzroča nastajanje rdečih in luskinastih zaplat na koži in vnetje sklepov);
(Invented) name Strength 
(Izmišljeno) ime
Date of first authorisation: 23 April 2014 Date of latest renewal: 18 December 2018 
Datum prve odobritve: 23. april 2014 Datum zadnjega podaljšanja: 18. december 2018
Some patients had more than one amputation. 
Nekateri bolniki so imeli več kot eno amputacijo.
The mean age was 63 years and 64% were male. 
Povprečna starost je bila 63 let, 64% je bilo moških.
Vital status was obtained for 99.6% of subjects across the studies. 
Podatke o vitalnem statusu so v okviru obeh študij pridobili pri 99,6% preiskovancev.
Take the medicine pack with you. 
Škatlo z zdravilom vzemite s seboj.
• If you forget to take a dose, take it as soon as you remember. 
• Če ste pozabili vzeti odmerek, ga vzemite takoj, ko se spomnite.
Not known (freqency cannot be estimated from the available data) 
Neznana pogostnost (pogostnosti ni mogoče oceniti iz razpoložljivih podatkov)
• if you drink alcohol to excess (either every day or from time to time) 
• če prekomerno uživate alkohol (bodisi vsakodnevno ali samo občasno)
Do not store above 30°C. 
Shranjujte pri temperaturi do 30C.
The percentage of minor and major amputations is based on the highest level amputation for each patient. 
Odstotek manjših in večjih amputacij temelji na največji ravni amputacije pri posameznem bolniku.
• about what you can do to prevent dehydration (see section 4 for signs of dehydration). 
• kaj lahko storite, da boste preprečili dehidracijo (glejte poglavje 4 za znake dehidracije).
The mean Vd ranged between 63-276 litres. 
Povprečni Vd je znašal 63-276 litrov.
Note: Incidence is based on the number of patients with at least one amputation, and not the total number of amputation events. 
Opomba: Incidenca temelji na številu bolnikov z najmaj eno amputacijo in ne na celotnem številu amputacij.
A patient's follow-up is calculated from Day 1 to the first amputation event date. 
Trajanje spremljanja bolnika je računano od 1. dne v študiji do datuma prve amputacije.
17% of patients were Hispanic. 
17% bolnikov je bilo latinskoameriškega izvora.
In patients at increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.g. every 3-6 months. 
Pri bolnikih s povečanim tveganjem dodatnega napredovanja okvare ledvic in pri starejših je treba delovanje ledvic oceniti pogosteje, na primer vsake 3--6 mesecev.
canagliflozin N = 5,790 
kanagliflozin N = 5.790
The effect of being homozygote (UGT1A9*3/*3, frequency < 0.1%) is probably more marked, but has not been investigated. 
Verjetno je učinek večji, če je posameznik homozigot (UGT1A9*3/*3, pogostnost < 0,1%), vendar tega niso preiskovali.
Severe allergic reaction (rare, may affect up to 1 in 1,000 people) Possible signs of severe allergic reaction may include: 
Huda alergijska reakcija (redko, pojavi se lahko pri največ 1 od 1.000 bolnikov) Možni znaki hude alergijske reakcije lahko vključujejo:
The amputation results for the Integrated CANVAS Program are shown in table 2. 
Z amputacijami povezani rezultati v integriranem programu CANVAS so prikazani v preglednici 2.
However, if it is time for the next dose, skip the missed dose. 
Če pa je že čas za naslednji odmerek, izpustite pozabljeni odmerek.
Vokanamet is not recommended for children and adolescents under 18 years, because data are not available in these patients. 
Pri otrocih in mladostnikih, ki so stari manj kot 18 let, uporaba zdravila Vokanamet ni priporočljiva, ker ni razpoložljivih podatkov o uporabi pri teh bolnikih.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking or continuing to take this medicine. 
Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo ali preden nadaljujete z jemanjem tega zdravila.
• if you have type 1 diabetes because Vokanamet should not be used to treat this condition. 
• če imate sladkorno bolezen tipa 1, saj se za zdravljenje te bolezni zdravila Vokanamet ne sme uporabljati.
Component of a 3 bottle multipack, can not be sold separately. 
Sestavni del skupnega pakiranja s 3 škatlami, ki se jih ne sme izdajati posamezno.
What Vokanamet is and what it is used for 
Kaj je zdravilo Vokanamet in za kaj ga uporabljamo
An eGFR should be assessed before initiation of treatment with metformin containing products and at least annually thereafter. 
Vrednost eGFR je treba oceniti pred uvedbo zdravljenja z zdravili, ki vsebujejo metformin, nato pa vsaj enkrat letno.
As an underlying mechanism has not been established, risk factors, apart from general risk factors, for amputation are unknown. 
Osnovnega mehanizma niso ugotovili, zato dejavniki tveganja za amputacije (razen splošnih dejavnikov tveganja) niso znani.
• Swallow the tablet whole with water. 
• Tableto pogoltnite celo skupaj z vodo.
As precautionary measures, consideration should be given to carefully monitoring patients with a higher risk for amputation events and counselling patients about the importance of routine preventative foot care and maintaining adequate hydration. 
Iz previdnosti je treba razmisliti o skrbnem spremljanju bolnikov z večjim tveganjem za dogodke, ki vodijo do amputacije, in opozarjanju bolnikov na pomembnost rutinske preventivne nege stopal in vzdrževanja zadostne hidracije.
Treatment with Vokanamet may be restarted when the ketone values are normal and the patient's condition has stabilised. 
Zdravljenje z zdravilom Vokanamet je mogoče ponovno uvesti, ko so vrednosti ketonov normalne is se bolnikovo stanje stabilizira.
Patients in CANVAS and CANVAS-R were followed for an average of 5.7 and 2.1 years, respectively. 
Bolnike v študijah CANVAS in CANVAS-R so v povprečju spremljali 5,7 oziroma 2,1 let.
• in muscle, by increasing insulin sensitivity, improving peripheral glucose uptake and utilisation 
• v mišicah poveča občutljivost za insulin, izboljša periferni privzem in koriščenje glukoze
• swelling of the face, lips, mouth, tongue, or throat that may lead to difficulty breathing or swallowing. 
• otekanje obraza, ustnic, ust, jezika, grla, zaradi česar je lahko oteženo dihanje ali požiranje.
Patients had an overall mean age of 59.5 years (range 21 years to 96 years), with 3,135 patients ≥ 65 years of age and 513 patients ≥ 75 years of age. 
Povprečna starost vseh bolnikov je bila 59,5 let (od 21 do 96 let), pri čemer je bilo 3.135 bolnikov starih najmanj 65 let, 513 bolnikov pa najmanj 75 let.
Secondary endpoints within a sequential conditional hypothesis testing were all-cause mortality and cardiovascular mortality. 
Sekundarna opazovana dogodka s sekvenčnim pogojnim testiranjem hipotez sta bila umrljivost iz kateregakoli vzroka in kardiovaskularna umrljivost.
These studies were multicenter, multi-national, randomised, double-blind, parallel group, with similar inclusion and exclusion criteria and patient populations. 
Gre za multicentrični, mednarodni, randomizirani, dvojno slepi študiji z vzporedno primerjavo zdravljenih skupin, ki imata med seboj podobne vključitvene in izključitvene kriterije in zajemata podobni populaciji bolnikov.
Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption, which may very rarely result in clinically significant vitamin B12 deficiency (e.g., megaloblastic anaemia). 
Dolgotrajno zdravljenje z metforminom je povezano z zmanjšanjem absorpcije vitamina B12, kar pa le zelo redko povzroči klinično pomembno pomanjkanje vitamina B12 (npr. megaloblastno anemijo).
All-cause mortality 
Umrljivost iz kateregakoli vzroka
What you need to know before you take Vokanamet 
Kaj morate vedeti, preden boste vzeli zdravilo Vokanamet
Stop taking this medicine immediately and contact a doctor or the nearest hospital straight away (see section 2). 
Takoj prenehajte jemati to zdravilo in nemudoma obvestite zdravnika ali koga v najbližji bolnišnici (glejte poglavje 2).
Active-controlled studies 
Študije nadzorovane z učinkovino
In addition, in such patients greater decreases in eGFR were reported (see sections 4.2 and 4.8). 
Poleg tega so pri teh bolnikih poročali tudi o večjem zmanjšanju eGFR (glejte poglavji 4.2 in 4.8).
The maximum daily dose of metformin should preferably be divided into 2-3 daily doses. 
Najbolje je, da se največji dnevni odmerek metformina je razdeli v 2-3 dnevne odmerke.
Necrotising fasciitis of the perineum (Fournier's gangrene) 
Nekrotizirajoči fasciitis presredka(Fournierova gangrena)
Sixty-six percent of subjects had a history of established cardiovascular disease, with 56% having a history of coronary disease, 19% with cerebrovascular disease, and 21% with peripheral vascular disease; 14% had a history of heart failure. 
Šestinšestdeset odstotkov preiskovancev je imelo v anamnezi ugotovljeno kardiovaskularno bolezen, pri čemer jih je imelo 56% v anamnezi koronarno bolezen, 19% cerebrovaskularno bolezen in 21% bolezen perifernega žilja, 14% pa jih je imelo v anamnezi srčno popuščanje.
For study results with respect to combination of therapies, effects on glycaemic control and cardiovascular events, and the populations studied, see sections 4.4, 4.5 and 5.1. 
Za rezultate študij glede na kombinacije zdravil, učinke na urejenost glikemije in kardiovaskularne dogodke ter preiskovane populacije glejte poglavja 4.4, 4.5 in 5.1.
Combinations requiring precautions for use 
Kombinacije, pri katerih so potrebni previdnostni ukrepi
In controlled clinical studies, Cmax did not exceed 5 μg/mL, even at maximum doses. 
V nadzorovanih kliničnih študijah Cmax tudi pri najvišjih odmerkih ni presegal 5 µg/ml.
• reduced body temperature and heartbeat 
• znižano telesno temperaturo in počasen srčni utrip
In the CANVAS Program, median duration of the infection was longer in the canagliflozin group compared to the placebo group. 
V programu CANVAS je bila mediana trajanja okužbe daljša v skupini, ki je prejemala kanagliflozin kot v skupini s placebom.
At baseline, patients were treated with one or more antidiabetic medications including metformin (77%), insulin (50%), and sulfonylurea (43%). 
Ob izhodišču so bolniki prejemali enega ali več antidiabetikov, vključno z metforminom (77%), insulinom (50%) in sulfonilsečnino (43%).
You may need more frequent blood glucose and kidney function tests, or your doctor may need to adjust the dose of Vokanamet. 
Morda boste morali pogosteje opravljati preiskave glukoze v krvi in delovanje ledvic, zdravnik pa bo morda moral prilagoditi odmerek zdravila Vokanamet.
Multiple amputations (some involving both lower limbs) were observed infrequently and in similar proportions in both treatment groups. 
Več amputacij pri enem bolniku (v nekaterih primerih odstranitev obeh spodnjih okončin) so opazili le redko in v podobnih deležih pri obeh zdravljenih skupinah.
The imbalance occurred as early as the first 26 weeks of therapy. 
Razlike so se pojavile že po prvih 26 tednih zdravljenja.
The primary endpoint in the CANVAS Program was the time to first occurrence of a MACE. 
Primarni opazovani dogodek v programu CANVAS je bil čas do prvega pojava pomembnega kardiovaskularnega neželenega dogodka (MACE).
58% of patients were male. 
Oseminpetdeset odstotkov (58%) bolnikov je bilo moškega spola.
Gastrointestinal symptoms such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite occur most frequently during initiation of therapy and resolve spontaneously in most cases. 
Gastrointestinalni simptomi, kot so navzea, bruhanje, diareja, bolečine v trebuhu in izguba apetita, se najpogosteje pojavljajo ob začetku zdravljenja in v večini primerov spontano izzvenijo.
If Fournier's gangrene is suspected, Vokanamet should be discontinued and prompt treatment (including antibiotics and surgical debridement) should be instituted. 
Če obstaja sum na Fournierovo gangreno, je treba zdravilo Vokanamet ukiniti in uvesti takojšnje zdravljenje (vključno z antibiotiki in kirurško odstranitvijo prizadetega tkiva).
These symptoms could be a sign of a rare but serious or even life-threatening infection, called necrotising fasciitis of the perineum or Fournier's gangrene which destroys the tissue under the skin. 
Ti simptomi so lahko znak redke, vendar resne ali celo življenjsko nevarne okužbe, ki se imenuje nekrotizirajoči fasciitis presredka ali Fournierova gangrena, ki uniči tkivo pod kožo.
Metformin is excreted unchanged in the urine. 
Metformin se izloča z urinom v nespremenjeni obliki.
• lower limb amputations (mainly of the toe) especially if you are at high risk of heart disease. 
• amputacije spodnjih okončin (večinoma prstov na nogah), še posebej, če imate večje tveganje za bolezni srca
OUTER CARTON FOR 1 COMPONENT OF MULTIPACK (WITHOUT BLUE BOX) 
ZUNANJA ŠKATLA ENEGA DELA SKUPNEGA PAKIRANJA (BREZ PODATKOV V MODREM OKENCU)
• It is important to check your feet regularly and adhere to any other advice regarding foot care and adequate hydration given by your healthcare professional. 
• Pomembno je, da si redno pregledujete stopala in upoštevate nasvete zdravstvenih delavcev o negi stopal in vzdrževanju zadostne količine telesnih tekočin (hidracije).
In in vitro studies, canagliflozin neither inhibited cytochrome P450 CYP1A2, CYP2A6, CYP2C19, CYP2D6, or CYP2E1, CYP2B6, CYP2C8, CYP2C9, nor induced CYP1A2, CYP2C19, CYP2B6, 
V in vitro študijah kanagliflozin pri odmerkih, višjih od terapevtskih, ni niti zaviral izoencimov citokroma P450 CYP1A2,CYP2A6, CYP2C19, CYP2D6, ali CYP2E1, CYP2B6, CYP2C8, CYP2C9, niti induciral CYP1A2, CYP2C19, CYP2B6, CYP3A4.
Regardless of treatment with canagliflozin or placebo, the risk of amputation was highest in patients with a baseline history of prior amputation, peripheral vascular disease, and neuropathy. 
Ne glede na zdravljenje s kanagliflozinom ali placebom je bilo tveganje za amputacijo največje pri bolnikih, ki so imeli ob izhodišču anamnezo predhodne amputacije, bolezen perifernega žilja in nevropatijo.
Renal function eGFR should be assessed before treatment initiation and regularly thereafter (see section 4.2). 
Delovanje ledvic eGFR je treba oceniti pred uvedbo zdravljenja, nato pa v rednih presledkih (glejte poglavje 4.2).
The risk of lower limb amputation was not dose-dependent. 
Tveganje za amputacijo spodnje okončine ni bilo odvisno od velikosti odmerka.
The Leydig cell tumours are associated with an increase in luteinising hormone (LH), which is a known mechanism of Leydig cell tumour formation in rats. 
Tumorji Leydigovih celic so povezani zvišanjem koncentracije luteinizirajočega hormona (LH), kar je že znan mehanizem tvorbe tumorja Leydigovih celic pri podganah.
See section 4.4 and description of AR below. 
Glejte poglavje 4.4 in opis neželenega učinka spodaj.
Patients with baseline HbA1c > 10% to ≤ 12% 
Bolniki z izhodiščno koncentracijo HbA1c od > 10% do ≤ 12%
Both improvement in glycaemic control and reduction of cardiovascular morbidity and mortality are an integral part of the treatment of type 2 diabetes. 
Tako izboljševanje urejenosti glikemije kot zmanjševanje obolevnosti in mortalnosti zaradi kardiovaskularnih bolezni sta bistvena elementa zdravljenja sladkorne bolezni tipa 2.
Balanitis or balanoposthitis occurred primarily in uncircumcised male patients which in some instances resulted in phimosis and/or circumcision. 
Do balanitisa oziroma balanopostitisa je prihajalo predvsem pri moških bolnikih, ki niso bili obrezani, kar je v nekaterih primerih povzročilo fimozo in/ali vodilo v cirkumcizijo.
Lactic acidosis is a medical emergency and must be treated in a hospital. 
Laktacidoza je urgentno zdravstveno stanje in ga je treba zdraviti v bolnišnici.
Some studies indicate that taking canagliflozin may have contributed to the risk of lower limb amputation (mainly toe and midfoot amputations). 
Nekatere študije kažejo, da lahko jemanje kanagliflozina prispeva k tveganju za amputacije spodnjih okončin (večinoma prstov na nogah in dela stopala).
Temporarily stop taking Vokanamet if you have a condition that may be associated with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal. 
Začasno prenehajte jemati zdravilo Vokanamet, če imate stanje, ki je lahko povezano z dehidracijo (znatna izguba telesnih tekočin), kot je hudo bruhanje, driska, povišana telesna temperatura, izpostavljenost vročini ali, če pijete manj tekočine kot običajno.
Canagliflozin may add to the effect of diuretics and may increase the risk of dehydration and hypotension (see section 4.4). 
Kanagliflozin lahko okrepi delovanje diuretikov in poveča tveganje za dehidracijo in hipotenzijo (glejte poglavje 4.4).
The European Medicines Agency has waived the obligation to submit the results of studies with Vokanamet in all subsets of the paediatric population in type 2 diabetes (see section 4.2 for information on paediatric use). 
Evropska agencija za zdravila je začasno odložila zahtevo za predložitev rezultatov študij z zdravilom Vokanamet za eno ali več podskupin pediatrične populacije pri sladkorni bolezni tipa 2 (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
• Severe renal failure (eGFR < 30 mL/min) (see sections 4.2 and 4.4); 
• Huda ledvična odpoved (eGFR < 30 ml/min ) (glejte poglavji 4.2 in 4.4).
Safety data profiles from individual pivotal studies (including studies in moderately renally impaired patients; older patients [≥ 55 years of age to ≤ 80 years of age]; patients with increased CV-risk) were generally consistent with the adverse reactions identified in this table. 
Profili varnostnih podatkov iz posameznih ključnih študij (vključno s študijami z bolniki z zmerno okvaro ledvic, s starejšimi bolniki [starih od ≥ 50 do ≤ 80 let]; bolnikih s povečanim tveganjem za kardiovaskularne bolezni) so se večinoma ujemali z neželenimi učinki, ki so navedeni v tej preglednici.
The racial distribution of patients who received canagliflozin was 72% White, 16% Asian, 5% Black, and 8% other groups. 
Med bolniki, ki so prejemali kanagliflozin, je bila pripadnost različnim rasam naslednja: 72% bolnikov je bilo bele rase, 16% azijske rase, 5% črne rase, 8% je bilo pripadnikov drugih etničnih skupin.
The effect of concomitant administration of canagliflozin (a weak P-gp inhibitor) on dabigatran etexilate (a P-gp substrate) has not been studied. 
Učinka sočasne uporabe kanagliflozina (šibkega zaviralca P-gp) na dabigatran eteksilat (substrat P-gp) niso preučevali.
Lactic acidosis (very rare, may affect up to 1 in 10,000 people) Vokanamet may cause a very rare but very serious side effect called lactic acidosis (see section “Warnings and precautions”). 
Laktacidoza (zelo redko, pojavi se lahko pri največ 1 od 10.000 bolnikov) Zdravilo Vokanamet lahko povzroči zelo redek a zelo resen neželeni učinek, imenovan laktacidoza (glejte poglavje “Opozorila in previdnostni ukrepi”).
The mean HbA1c at baseline was 8.2% and mean duration of diabetes was 13.5 years. 
Povprečna koncentracija HbA1c ob izhodišču je bila 8,2%, povprečno trajanje sladkorne bolezni pa je bilo 13,5 let.
N = 4,344 
placebo N = 4.344
Lactic acidosis, a very rare but serious metabolic complication, most often occurs at acute worsening of renal function or cardiorespiratory illness or sepsis. 
Laktacidoza, zelo redek, a resen presnovni zaplet, se najpogosteje pojavi ob akutnem poslabšanju delovanja ledvic, ob kardiorespiratorni bolezni ali sepsi.
The safety of canagliflozin was evaluated in 18,248 patients with type 2 diabetes, including 13,791 patients treated with canagliflozin in combination with metformin. 
Varnost uporabe kanagliflozina so ocenjevali pri 18.248 bolnikih s sladkorno boleznijo tipa 2, med katerimi je 13.791 bolnikov prejemalo kanagliflozin v kombinaciji z metforminom.
In general, elevations were transient and did not require specific treatment. 
Zvišanja vrednosti kalija v serumu so bila večinoma prehodna in zaradi njih ni bilo potrebno posebno zdravljenje.
Cardiovascular outcomes 
Kardiovaskularni izidi
Table 3: The frequency of metformin adverse reactions identified from clinical study and postmarketing data 
Preglednica 3: Pogostnost neželenih učinkov metformina, ugotovljena iz podatkov klinične študije in izkušenj v obdobju trženja
To assess risk factors for these adverse reactions, a larger pooled analysis (N = 12,441) of patients from 13 controlled phase 3 and phase 4 studies including both doses of canagliflozin was conducted. 
Za oceno dejavnikov tveganja za navedene neželene učinke so izvedli večjo analizo združenih podatkov bolnikov (n = 12.441) iz 13 nadzorovanih študij faze III in faze IV z obema odmerkoma kanagliflozina.
Adults with normal renal function (estimated glomerular filtration rate [eGFR] ≥ 90 mL/min/1.73 m 
Odrasli z normalnim delovanjem ledvic (z ocenjeno glomerulno filtracijo [eGFR] ≥ 90 ml/min/1,73 m
Heart failure requiring hospitalization 
Srčno popuščanje, zaradi katerega je potreben sprejem v bolnišnico
In case of dehydration (severe diarrhoea or vomiting, fever or reduced fluid intake), Vokanamet should be temporarily discontinued and contact with a healthcare professional is recommended. 
V primeru dehidracije (huda driska ali bruhanje, zvišana telesna temperatura ali zmanjšan vnos tekočine) je treba jemanje zdravila Vokanamet začasno prekiniti; priporoča se posvet z zdravstvenim delavcem.
CARTON FOR MULTIPACK COMPRISING 3 PACKS (INCLUDING BLUE BOX) 
ŠKATLA SKUPNEGA PAKIRANJA, KI OBSEGA 3 POSAMEZNA PAKIRANJA (VKLJUČNO S PODATKI V MODREM OKENCU)
The pack sizes are cartons of 20 and 60 tablets, and multipack cartons of 180 tablets (3 bottles containing 60 tablets each). 
Velikosti pakiranj so škatle z 20 ali 60 tabletami in škatle skupnega pakiranja s 180 tabletami (3 plastenke, vsaka s 60 tabletami).
Medicinal products that can acutely impair renal function (such as antihypertensives, diuretics and non-steroidal anti-inflammatory drugs [NSAIDs]) should be initiated with caution in Vokanamettreated patients. 
Zdravila, ki lahko akutno okvarijo delovanje ledvic (kot so antihipertenzivi, diuretiki in nesteroidna protivnetna zdravila), je treba pri bolnikih, ki se zdravijo z zdravilom Vokanamet, uvesti previdno.
Vokanamet may cause a very rare, but very serious side effect called lactic acidosis, particularly if your kidneys are not working properly. 
Zdravilo Vokanamet lahko povzroči zelo redek, a zelo resen neželeni učinek, imenovan laktacidoza, zlasti, če ledvice ne delujejo pravilno.
A paediatric phase 1 study examined the pharmacokinetics and pharmacodynamics of canagliflozin in children and adolescents ≥ 10 to < 18 years of age with type 2 diabetes mellitus. 
V pediatrični študiji faze 1 so preučevali farmakokinetiko in farmakodinamiko kanagliflozina pri otrocih in mladostnikih s sladkorno boleznijo tipa 2, starih ≥ 10 do < 18 let.
Concomitant antidiabetic and atherosclerotic therapies could be adjusted, according to the standard care for these diseases. 
Sočasno odmerjanje antidiabetikov in zdravil za aterosklerozo so smeli prilagoditi skladno z načeli standardne oskrbe pri teh dveh boleznih.