natgillin/translations-raw huggingface dataset:
The combination of valsartan/HCTZ was generally well-tolerated and the adverse event and adverse drug reaction profiles were consistent with the pharmaceutical class. 
Kombinacijo valsartana/hidroklorotiazida so bolniki na splošno dobro prenašali, profili neželenih učinkov in reakcij na zdravilo pa so bili v skladu s farmacevtskim razredom.
Whilst there is no controlled epidemiological data on the risk with Angiotensin II Receptor Inhibitors (AIIRAs), similar risks may exist for this class of drugs. 
Čeprav ni na voljo podatkov glede tveganja pri uporabi antagonistov angiotenzina II iz kontroliranih epidemioloških študij, lahko podobno tveganje obstaja tudi za to skupino zdravil.
Patients with severe chronic heart failure or other conditions with stimulation of the reninangiotensin-aldosterone-system 
Bolniki s hudim kroničnim srčnim popuščanjem ali z drugimi boleznimi, pri katerih je stimuliran sistem renin-angiotenzin-aldosteron
Hence it cannot be excluded that because of the inhibition of the renin-angiotensin-aldosterone system the application of Diovan Comp as well may be associated with impairment of the renal function. 
Iz tega razloga ni mogoče izključiti, da bi bila zaradi zaviranja sistema renin-angiotenzin-aldosteron tudi uporaba zdravila Diovan Comp povezana z motenim delovanjem ledvic.
Increase of dosage of probenecid or sulfinpyrazone may be necessary. 
Včasih je treba zvišati odmerjanje probenecida ali sulfinpirazona.
• anti-cholinergic medicines, such as atropine or biperiden 
• antiholinergična zdravila, kot sta atropin ali biperiden
ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORMS, STRENGTHS OF THE MEDICINAL PRODUCTS, ROUTES OF ADMINISTRATION, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES 
DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, PREDLAGATELJEV, IMETNIKOV DOVOLJENJA ZA PROMETZ ZDRAVILOM V DRŽAVAH ČLANICAH
In rats, maternally toxic doses of valsartan (600 mg/kg/day) during the last days of gestation and lactation led to lower survival, lower weight gain and delayed development (pinna detachment and ear-canal opening) in the offspring (see section 4.6). 
Pri podganah so odmerki, toksični za mater, (600 mg/kg/dan) v zadnjih dneh brejosti in med dojenjem povzročili zmanjšano preživetje, nižjo telesno maso, upočasnitev razvoja (neprirasel uhelj in odprt ušesni kanal) (glejte poglavje 4.6) pri potomstvu.
These medicinal products may potentiate the effect of hydrochlorothiazide on serum potassium (see section 4.4). 
Ta zdravila lahko okrepijo delovanje hidroklorotiazida na koncentracijo kalija v serumu (glejte poglavje 4.4).
According with CHMP recommendation, have been included interaction with valsartan and interaction with hydroclortiazide. 
V skladu s priporočili CHMP sta bili vključeni medsebojno delovanje z valsartanom in medsebojno delovanje s hidroklorotiazidom.
• lung infection; breathlessness 
• pljučna okužba; zadihanost
This will help you to get the best results and lower the risk of side effects. 
Tako bodo rezultati najboljši in tveganje neželenih učinkov najmanjše.
As for any patient receiving diuretic therapy, periodic determination of serum electrolytes should be performed at appropriate intervals. 
Kot pri vsakem bolniku, ki prejema diuretike, je treba občasno v ustreznih intervalih določati koncentracije elektrolitov v serumu.
Section 4.4 - Special Warnings and Precautions for Use 
Poglavje 4.4 - Posebna opozorila in previdnostni ukrepi
• if you have severe heart disease. 
• če imate hudo srčno bolezen.
Non-steroidal anti-inflammatory medicines (NSAIDs), including selective COX-2 inhibitors, acetylsalicylic acid >3 g/day), and non-selective NSAIDs NSAIDS can attenuate the antihypertensive effect of both angiotensin II antagonists and hydrochlorothiazide when administered simultaneously. 
Nesteroidna protivnetna zdravila (NSAIDs), vključno s selektivnimi zaviralci COX-2, z acetilsalicilno kislino >3 g/dan in z neselektivnimi nesteroidnimi protivnetnimi zdravili (NSAIDs) Sočasna uporaba nesteroidnih protivnetnih zdravil lahko zmanjša antihipertenzivni učinek tako antagonistov angiotenzina II kot hidroklorotiazida.
cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol) 
ciamemazin, sulpirid, sultoprid, amisulprid, tiaprid, pimozid, haloperidol, droperidol),
Pharmacotherapeutic group: Angiotensin II antagonists and diuretics, valsartan and diuretics; ATC code: C09D A03. 
Farmakoterapevtska skupina: antagonisti angiotenzina II in diuretiki, valsartan in diuretiki, oznaka ATC: C09DA03
• the level of bilirubin increased in blood (which can, in severe cases, trigger yellow skin and eyes) 
• zvišana raven bilirubina v krvi (ki v hujših primerih lahko povzroči rumene oči in kožo)
• other medicines to lower your blood pressure, such as beta blockers or methyldopa, or medicines that tighten your blood vessels or stimulate your heart, such as noradrenaline or adrenaline 
• druga zdravila za zniževanje krvnega tlaka, kot so zaviralci adrenergičnih receptorjev beta ali metildopa, ali zdravila, ki zožijo krvne žile ali spodbujajo delovanje srca, kot sta noradrenalin ali adrenalin
However, these tests were performed separately with valsartan and hydrochlorothiazide, and produced no evidence of mutagenicity, chromosomal breakage or carcinogenicity. 
Vendar pa so te teste opravili ločeno z valsartanom in s hidroklorotiazidom in pri tem niso opažali nobenih znakov mutagenosti, lomljenja kromosomov ali karcinogenosti.
Method of administration Diovan Comp can be taken with or without food and should be administered with water. 
Način uporabe Zdravilo Diovan Comp je mogoče jemati s hrano ali brez nje, treba pa ga je zaužiti z vodo.
• skin peeling 
• luščenje kože
Like all medicines, Diovan Comp can cause side effects, although not everybody gets them. 
Kot vsa zdravila ima lahko tudi zdravilo Diovan Comp neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
• some antibiotics (tetracyclines), anaesthetics and sedatives 
• nekateri antibiotiki (tetraciklini), anestetiki in pomirjevala
Aortic and mitral valve stenosis, hypertrophic obstructive cardiomyopathy As with all other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or hypertrophic obstructive cardiomyopathy (HOCM). 
Stenoza aortne in mitralne zaklopke, hipertrofična obstruktivna kardiomiopatija Kot pri uporabi drugih vazodilatatorjev je potrebna posebna pozornost pri bolnikih z aortno ali mitralno stenozo ali s hipertrofično obstruktivno kardiomiopatijo (hypertrophic obstructive cardiomyopathy - HOCM).
For hydrochlorotiazide, >95% of the absorbed dose being excreted as unchanged compound in the urine. 
Po peroralni uporabi se več kot 95 % absorbiranega odmerka hidroklorotiazida izloči v nespremenjeni obliki z urinom.
Regarding the highest dose only, the CHMP agreed the following: “If no relevant additional effect is seen with Diovan Comp 320 mg/25 mg after 8 weeks, treatment with an additional or alternative antihypertensive medicinal product should be considered (see section 5.1)”. 
Samo v zvezi z najvišjim odmerkom je CHMP sprejel sledeče: „Če po 8 tednih ni opažen pomemben dodatni učinek zdravila Diovan Comp 320 mg/25 mg, je treba razmisliti o uporabi dodatnega ali alternativnega antihipertenzivnega zdravila (glejte poglavje 5.1)
In patients with mild to moderate hepatic impairment without cholestasis the dose of valsartan should not exceed 80 mg (see section 4.4). 
Pri bolnikih z blago do zmerno okvaro jeter brez holestaze odmerek valsartana ne sme presegati 80 mg (glejte poglavje 4.4).
• constipation, discomfort of the stomach or bowels, liver disorders (yellow skin or eyes) 
• obstipacija, bolečine v želodcu ali črevesju, bolezni jeter (rumena koža ali oči)
These doses in rats (600 mg/kg/day) are approximately 18 times the maximum recommended human dose on a mg/m2 basis (calculations assume an oral dose of 320 mg/day and a 60-kg patient). 
Ti odmerki pri podganah (600 mg/kg/dan) so približno 18-krat večji od največjega priporočenega odmerka za ljudi na osnovi mg/m2 (izračun predvideva peroralni odmerek 320 mg/dan in 60-kg bolnika).
The valsartan - hydrochlorothiazide combination was not tested for mutagenicity, chromosomal breakage or carcinogenicity, since there is no evidence of interaction between the two substances. 
Kombinacije valsartan - hidroklorotiazid niso testirali glede mutagenosti, povzročanja lomljenja kromosomov ali karcinogenosti, ker ni bilo nobenih znakov za interakcije med obema učinkovinama.
Hydrochlorothiazide is excreted in human milk. 
Hidroklorotiazid se pri človeku izloča v materino mleko.
Reduction in serum potassium occurred more frequently in patients given 25 mg hydrochlorothiazide than in those given 12.5 mg hydrochlorothiazide. 
Do znižanja koncentracije kalija v serumu je prišlo bolj pogosto pri bolnikih, ki so jemali 25 mg hidroklorotiazida, kot pri tistih, ki so jemali 12,5 mg hidroklorotiazida.
Abrupt withdrawal of valsartan has not been associated with rebound hypertension or other adverse clinical events. 
Po nenadni prekinitvi jemanja valsartana ni prišlo do povratne hipertenzije ali drugih neželenih kliničnih dogodkov.
The antihypertensive effect is substantially present within 2 weeks. 
Do znatnega antihipertenzivnega učinka pride v 2 tednih.
mizolastin, pentamidine, sparfloxacine, terfenadine, vincamine i.v.) 
mizolastin, pentamidin, sparfloksacin, terfenadin, vinkamin i.v.
Food decreases exposure (as measured by AUC) to valsartan by about 40% and peak plasma concentration (Cmax) by about 50%, although from about 8 h post dosing plasma valsartan concentrations are similar for the fed and fasted groups. 
Hrana zmanjša izpostavljenost valsartanu (merjeno z AUC) za okrog 40 % in njegovo najvišjo koncentracijo v plazmi (Cmax) za okrog 50 %, vendar pa je od približno 8. ure po odmerjanju koncentracija valsartana v plazmi približno enaka pri skupini preiskovancev, ki so jedli, in pri tistih, ki so vzeli zdravilo na tešče.
Patients were randomised to one of 3 doses of valsartan (160, 320 and 640 mg/od) and treated for 30 weeks. 
Bolniki so bili randomizirani v eno od 3 skupin z odmerki valsartana 160, 320 ali 640 mg enkrat na dan, ki so jih prejemali 30 tednov.
Table 3: Frequency of adverse reactions with hydrochlorothiazide Hydrochlorothiazide has been extensively prescribed for many years, frequently in higher doses than those administered with Diovan Comp. 
Pogostnosti neželenih učinkov hidroklorotiazida Hidroklorotiazid že več let široko predpisujejo, pogosto v odmerkih, ki so večji od odmerkov pri uporabi zdravila Diovan Comp.
The CHMP agreed on including in the harmonised PI interaction of Diovan Comp with: Metformin and iodine contrast agents. 
CHMP se je strinjal, da se v usklajene podatke o zdravilu vključi medsebojno delovanje zdravila Diovan Comp z: metforminom in jodnimi kontrastnimi sredstvi.
Diovan Comp may increase the effects of other agents with antihypertensive properties (e.g. ACEI, beta blockers, calcium channel blockers). 
Zdravilo Diovan Comp lahko poveča učinek drugih zdravil z antihipertenzivnim delovanjem (na primer zaviralcev ACE, zaviralcev adrenergičnih receptorjev beta, zaviralcev kalcijevih kanalčkov).
The mode of action of thiazides is through inhibition of the Na+Cl- symporter perhaps by competing for the Cl- site, thereby affecting electrolyte reabsorption mechanisms:directly increasing sodium and chloride excretion to an approximately equal extent, and indirectly by this diuretic action reducing plasma volume, with consequent increases in plasma renin activity, aldosterone secretion and urinary potassium loss, and a decrease in serum potassium. 
Tiazidi delujejo tako, da verjetno tekmujejo za vezavno mesto za Cl- ione na skupnem prenašalcu Na+ in Cl- ionov in ga na ta način zavirajo, s tem pa vplivajo na mehanizme reabsorpcije elektrolitov: neposredno povečajo izločanje natrija in klorida v približno enaki meri, posredno pa s takim diuretičnim delovanjem zmanjšajo volumen plazme, s tem povzročijo zvišanje delovanja renina v plazmi, izločanje aldosterona in izgubljanje kalija z urinom ter znižano koncentracijo kalija v serumu.
If no relevant additional effect is seen with Diovan Comp 320 mg/25 mg after 8 weeks, treatment with an additional or alternative antihypertensive medicinal product should be considered (see section 5.1). 
Če po 8 tednih uporabe zdravila Diovan Comp 320 mg/25 mg ni opaziti ustreznega dodatnega učinka, je treba razmisliti o uvedbi dodatnega ali drugega antihipertenzivnega zdravila (glejte poglavje 5.1).
There is no data available on the use of valsartan in patients with severe hepatic dysfunction (see section 4.3). 
Razpoložljivih podatkov o uporabi valsartana pri bolnikih s hudo motnjo delovanja jeter ni (glejte poglavje 4.3).
Based on the pharmacological mechanism of action of hydrochlorothiazide its use during the second and third trimester may compromise foeto-placental perfusion and may cause foetal and neonatal effects like icterus, disturbance of electrolyte balance and thrombocytopenia. 
Glede na farmakološki mehanizem delovanja hidroklorotiazida lahko njegova uporaba v drugem in tretjem trimesečju ogroža fetoplacentarni krvni obtok in pri plodu in novorojenčku povzroči učinke, kot so ikterus, motnje v ravnovesju elektrolitov in trombocitopenijo.
• medicines to increase blood sugar levels, such as diazoxide 
• zdravila, ki zvišajo raven sladkorja v krvi, kot je diazoksid
− Refractory hypokalaemia, hyponatraemia, hypercalcaemia, and symptomatic hyperuricaemia. 
- Refraktarna hipokaliemija, hiponatriemija, hiperkalciemija in simptomatska hiperurikemija.
Thiazides may reduce urinary calcium excretion and cause an intermittent and slight elevation of serum calcium in the absence of known disorders of calcium metabolism. 
Tiazidi lahko zmanjšujejo izločanje kalcija z urinom in povzročajo občasno rahlo zvišanje koncentracije kalcija v serumu brez znanih motenj metabolizma kalcija.
− Severe renal impairment (creatinine clearance <30 ml/min), anuria. 
- Huda okvara ledvic (očistek kreatinina <30 ml/min), anurija.
No findings emerged that would exclude the use of therapeutic doses in man. 
Ugotovili niso ničesar, kar bi govorilo proti uporabi terapevtskih odmerkov pri ljudeh.
The data from the 2 factorial and 6 non-responders phase III clinical trials, demonstrate that valsartan administered in combination with HCTZ is effective in reducing BP in patients with essential hypertension without any added concern for safety and tolerability. 
Podatki iz dveh kliničnih preskušanj III. faze z odzivnimi bolniki in šestih kliničnih preskušanj III. faze z neodzivnimi bolniki dokazujejo, da je valsartan, dan v kombinaciji s hidroklorotiazidom, učinkovit pri zniževanju krvnega tlaka pri bolnikih z esencialno hipertenzijo in da ob tem ni nikakršnih dodatnih zadržkov glede varnosti in prenašanja zdravila.
Valsartan is an orally active and specific angiotensin II (Ang II) receptor antagonist. 
Valsartan je peroralno aktiven, močan in specifičen antagonist receptorjev angiotenzina II.
Digoxin and indomethacin could interact with the hydrochlorothiazide component of Diovan Comp (see interactions related to hydrochlorothiazide). 
Z digoksinom in indometacinom bi lahko prišlo do interakcij s hidroklorotiazidno sestavino zdravila Diovan Comp (glejte interakcije v zvezi s hidroklorotiazidom).
• dehydration (with symptoms of thirst, dry mouth and tongue, infrequent urination, dark colored urine, dry skin) 
• dehidracija (s simptomi žeje, suhih ust in jezika, poredkim mokrenjem, temno obarvanostjo urina in suho kožo)
The systemic availability of hydrochlorothiazide is reduced by about 30% when co-administered with valsartan. 
Sistemska biološka uporabnost hidroklorotiazida je pri sočasni uporabi valsartana manjša za približno 30 %.
How to store Diovan Comp Further information 
Shranjevanje zdravila Diovan Comp Dodatne informacije
Renal clearance of hydrochlorothiazide is composed of passive filtration and active secretion into the renal tubule. 
Ledvični očistek hidroklorotiazida je sestavljen iz pasivne filtracije in aktivne sekrecije v ledvični tubul.
- the scope of the referral was the harmonisation of the Summaries of Products Characteristics, labelling and package leaflet. 
- Predmet napotitve je bil uskladitev povzetkov glavnih značilnosti zdravila, označevanja in navodil za uporabo.
Dose adjustment of the antidiabetic medicinal product may be necessary. 
Včasih je treba prilagoditi odmerjanje antidiabetičnih zdravil.
In addition, the following signs and symptoms may occur due to an overdose of the hydrochlorothiazide component: nausea, somnolence, hypovolaemia, and electrolyte disturbances associated with cardiac arrhythmias and muscle spasms. 
Poleg tega lahko pri prevelikem odmerjanju hidroklorotiazida pride do naslednjih znakov in simptomov: do navzee, somnolence, hipovolemije in do elektrolitskega neravnovesja, povezanega s srčnimi aritmijami in mišičnimi spazmi.
• medicines to treat cancer, such as methotrexate or cyclophosphamide 
• zdravila za zdravljenje raka, kot sta metotreksat in ciklofosfamid
• hives and difficulties in breathing 
• koprivnica in težave z dihanjem
Frequency of adverse reactions with valsartan 
Pogostnosti neželenih učinkov valsartana
The above mentioned effects appear to be due to the pharmacological effects of high valsartan doses (blockade of angiotensin II-induced inhibition of renin release, with stimulation of the reninproducing cells) and also occur with ACE inhibitors. 
Zgoraj opisane učinke pripisujejo farmakološkemu delovanju visokih odmerkov valsartana (preprečevanju zaviranja sproščanja renina, ki ga povzroča angiotenzin II, in stimulaciji celic, v katerih nastaja renin).
In a clinical trial of patients with a history of dry cough during ACE inhibitor therapy, 19.5% of trial subjects receiving valsartan and 19.0% of those receiving a thiazide diuretic experienced cough compared to 68.5% of those treated with an ACE inhibitor (P <0.05). 
V kliničnem preskušanju pri bolnikih, ki so imeli v anamnezi suh kašelj v času zdravljenja z zaviralcem ACE, je do kašlja prišlo pri 19,5 % preiskovancev, ki so dobivali valsartan, pri 19,0 % tistih, ki so prejemali tiazidni diuretik, in pri 68,5 % preiskovancev, ki so dobivali zaviralec ACE (p < 0,05).
Valsartan does not inhibit ACE, also known as kininase II, which converts Ang I to Ang II and degrades bradykinin. 
Valsartan ne zavira angiotenzinske konvertaze ACE (znane tudi kot kininaza II), ki pretvarja angiotenzin I v angiotenzin II in razgrajuje bradikinin.
− Hypersensitivity to valsartan, hydrochlorothiazide, other sulfonamide-derived medicinal products or to any of the excipients. 
- Preobčutljivost za valsartan, hidroklorotiazid, druga sulfonamidna zdravila ali katerokoli pomožno snov.
The AIIR (angiotensin II receptor) antagonists should not be contraindicated during breast-feeding. 
Antagonisti angiotenzin II receptorjev naj ne bodo kontraindicirani med dojenjem.
The CHMP agreed that a greater reduction in both systolic and diastolic BP were seen in the non-responder studies for all strengths from week 4 to week 8 compared to the factorial studies. 
CHMP se je strinjal, da je bilo v primerjavi s študijami z odzivnimi bolniki v študijah z neodzivnimi bolniki opaženo večje znižanje tako sistolnega kot tudi diastolnega krvnega tlaka za vse jakosti od 4. do 8. tedna.
Interactions related to valsartan 
Interakcije v zvezi z valsartanom
Alcohol, anaesthetics and sedatives Potentiation of orthostatic hypotension may occur. 
Alkohol,anestetiki in pomirjevala Lahko pride do okrepljene ortostatske hipotenzije.
During repeated dosing, the maximum reduction in blood pressure with any dose is generally attained within 24 weeks and is sustained during long-term therapy. 
Do največjega znižanja krvnega tlaka po večkratnem odmerjanju pride pri kateremkoli odmerku v 2-4 tednih in to znižanje se med dolgotrajnim zdravljenjem ohranja.
In severely sodium-depleted and/or volume-depleted patients, such as those receiving high doses of diuretics, symptomatic hypotension may occur in rare cases after initiation of therapy with Diovan Comp. 
Pri bolnikih s hudim pomanjkanjem natrija in/ali hipovolemijo, ki prejemajo velike odmerke diuretikov, lahko v redkih primerih po začetku zdravljenja z zdravilom Diovan Comp pride do simptomatske hipotenzije.
• carbamazepine, a medicine used to treat seizure conditions 
• karbamazepin, zdravilo za zdravljenje epilepsije
When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately and, if appropriate, alternative therapy should be started. 
Ob potrjeni nosečnosti je treba zdravljenje z antagonisti angiotenzina II takoj prekiniti in, če je primerno, začeti alternativno zdravljenje.
• elevation of liver function values 
• zvišane vrednosti jetrnih testov
Regarding the concomitant use of alcohol during administration of Diovan Comp, the statement potentiation of orthostatic hypotension may occur was discussed. 
Glede sočasnega uživanja alkohola med uporabo zdravila Diovan Comp so obravnavali stavek lahko poslabša ortostatsko hipotenzijo.
• swollen face, tongue or pharynx 
• oteklina obraza, jezika ali žrela
Administration of valsartan to patients with hypertension results in reduction of blood pressure without affecting pulse rate. 
Pri bolnikih s hipertenzijo valsartan zniža krvni tlak, ne da bi vplival na srčno frekvenco.
The CHMP, noting that the treatment effects in patients with the higher baseline blood pressure were greater, concluded that a restriction of the use of valsartan/HCTZ 160/25 and 320/25 mg to patients with severely elevated blood pressure is not anymore warranted. 
CHMP je ob upoštevanju, da so bili učinki zdravljenja pri bolnikih z višjo mejno vrednostjo krvnega tlaka večji, zaključil, da omejitev pri uporabi valsartana/hidroklorotiazida 160/25 in 320/25 mg pri bolnikih z občutno povišanim krvnim tlakom ni več utemeljena.
Regarding Hepatic impairment the majority of valsartan is eliminated, mainly as unchanged drug in the bile, by hepatic clearance. 
Kar zadeva okvaro jeter, se večina valsartana izloči preko jeter, v glavnem kot nespremenjeno zdravilo v žolču.
If hypotension occurs, the patient should be placed in the supine position and salt and volume supplementation should be given rapidly. 
Če pride do hipotenzije, je treba bolnika položiti vznak in mu hitro nadomestiti elektrolite in tekočino.
In marmosets, damage was observed in the gastric mucosa (from 30 + 9 mg/kg/d). 
Pri marmozetkah so opažali poškodbe želodčne sluznice (pri odmerkih 30 + 9 mg/kg/dan).
Based on the QRD comments on the Diovan and on the class labelling text regarding the use of AIIRAs during pregnancy the section 4.6 was implemented. 
Na podlagi pripomb v okviru pregleda dokumentov glede kakovosti o zdravilu Diovan in besedila o oznaki skupine glede uporabe antagonistov angiotenzin II receptorjev med nosečnostjo je bilo vstavljeno poglavje 4.6.
The renin-aldosterone link is mediated by angiotensin II, so with co-administration of valsartan the reduction in serum potassium is less pronounced as observed under monotherapy with hydrochlorothiazide. 
Povezavo med reninom in aldosteronom predstavlja angiotenzin II, zato je pri sočasni uporabi valsartana znižanje koncentracije kalija v serumu manj izraženo kot pri monoterapiji s hidroklorotiazidom.
• You can take Diovan Comp with or without food. 
• Zdravilo Diovan Comp je mogoče jemati s hrano ali brez nje.
In case of diuretic-induced dehydration, there is an increased risk of acute renal failure, especially with high doses of the iodine product. 
Pri bolnikih, ki so zaradi jemanja diuretikov dehidrirani, obstaja povečano tveganje za akutno odpoved ledvic, posebno pri uporabi velikih odmerkov jodiranih sredstev.
Concomitant administration with food has been reported to both increase and decrease the systemic availability of hydrochlorothiazide compared with the fasted state. 
Za sočasno jemanje s hrano so zabeležili tako večjo kot tudi manjšo sistemsko uporabnost hidroklorotiazida v primerjavi z jemanjem na tešče.
Other hypersensitivity/allergic reactions including serum sickness 
Bolezni imunskega sistema pogostnost neznana druge preobčutljivostne/alergijske reakcije, vključno s serumsko boleznijo