natgillin/translations-raw huggingface dataset:
Like other immunosuppressants, ciclosporin increases the risk of developing lymphomas and other malignancies, particularly those of the skin. 
Tako kot drugi imunosupresivi tudi ciklosporin povečuje tveganje za razvoj limfoma in drugih malignih bolezni, še posebno malignih bolezni kože.
Like other immunosuppressants, ciclosporin predisposes patients to the development of a variety of bacterial, fungal, parasitic and viral infections, often with opportunistic pathogens. 
Tako kot drugi imunosupresivi tudi ciklosporin poveča nagnjenost bolnikov k razvoju različnih bakterijskih, glivičnih, parazitskih in virusnih okužb, pogosto z oportunističnimi patogeni.
Sandimmun oral solution should be diluted in a glass (not plastic) container with cold chocolate drink, milk, fruit juice or cola immediately before being taken, stirred well and drunk at once. 
Peroralno raztopino Sandimmun je treba tik pred zaužitjem razredčiti v steklenem (ne plastičnem) kozarcu s hladnim čokoladnim napitkom, mlekom, sadnim sokom ali kolo, jo dobro premešati in takoj izpiti.
Sandimmun suppresses the immune system and may also affect your body's ability to fight against infection. 
Zdravilo Sandimmun zavira imunski sistem v telesu in lahko oslabi obrambno sposobnost telesa proti okužbam.
The medicine will be diluted before use with saline or 5% glucose and then given to you by slow infusion. 
Zdravilo je treba razredčiti s fiziološko raztopino soli ali s 5-odstotno raztopino glukoze, prejeli pa ga boste s počasno infuzijo.
• Kidney problems which may greatly reduce the amount of urine you produce. 
• okvara ledvic, zaradi katere lahko pride do močno zmanjšanega izločanjem urina;
High blood pressure. 
• visok krvni tlak
• Migraine or severe headache often with feeling and being sick (nausea, vomiting) and being sensitive to light. 
• migrena ali hud glavobol, pogosto z občutkom slabosti (z navzeo), z bruhanjem in s preobčutljivostjo na svetlobo
A slight precipitate that may occur during storage does not affect the efficacy and safety of the drug. 
Med shranjevanjem se lahko pojavi manjša količina usedline, vendar ta ne vpliva na učinkovitost in varnost zdravila.
Before initiation of treatment a reliable baseline level of renal function should be established by at least two measurements. 
Pred začetkom zdravljenja je treba določiti zanesljive vrednosti izhodiščne stopnje ledvične funkcije z najmanj dvema meritvama.
• If you have an autoimmune disease, in which your body's immune response attacks your body's own cells, Sandimmun stops this immune reaction. 
• Če imate avtoimunsko bolezen, pri kateri vaš lasten imunski odziv napada celice vašega telesa, zdravilo Sandimmun zavira imunsko reakcijo pri taki bolezni.
More frequent checks are necessary when the Sandimmun dose is increased, or concomitant treatment with an NSAID is initiated or its dosage increased. 
Pogostejše meritve so potrebne v času višanja odmerka zdravila Sandimmun ali uvajanja sočasnega zdravljenja z nesteroidnim protivnetnim zdravilom oziroma višanja njegovega odmerka.
A treatment regimen containing multiple immunosuppressants (including ciclosporin) should therefore be used with caution as this could lead to lymphoproliferative disorders and solid organ tumours, some with reported fatalities. 
Iz tega razloga je pri uporabi shem zdravljenja, ki vsebujejo več imunosupresivov (vključno s ciklosporinom) potrebna previdnost, saj tako zdravljenje lahko povzroča limfoproliferativne bolezni in tumorje čvrstih organov, ki so se po poročilih v nekaterih primerih končali s smrtjo.
50 ml amber glass bottles with an aluminium cap and rubber stopper. 
50-mililitrska steklenica iz rjavega stekla z aluminijasto zaporko in gumijastim zamaškom.
If you are being treated for Behçet`s uveitis, your doctor will monitor you particularly carefully if you have neurological symptoms (for example: increased forgetfulness, personality changes noticed over time, psychiatric or mood disorders, burning sensation in limbs, decreased sensation in limbs, tingling sensation in limbs, weakness of limbs, walking disturbances, headache with or without nausea and vomiting, vision disturbances including restricted movement of eyeball). 
Če prejemate zdravilo zaradi Behçetovega uveitisa, vas bo zdravnik še posebej skrbno pregledoval glede nevroloških simptomov (kot so: povečana pozabljivost, osebnostne spremembe, ki jih opazite sčasoma, psihiatrične motnje ali motnje razpoloženja, žgoč občutek v okončinah, zmanjšana občutljivost v okončinah, mravljinčenje v okončinah, oslabelost okončin, motnje hoje, glavobol z občutkom slabosti in bruhanjem ali brez njih, motnje vida, vključno z omejeno gibljivostjo očesa).
This effect is often reversible with ciclosporin dose reduction. 
Ta učinek je po znižanju odmerka ciklosporina pogosto reverzibilen.
Once satisfactory response is achieved, Sandimmun may be discontinued and subsequent relapse managed with re-introduction of Sandimmun at the previous effective dose. 
Ko pride do zadovoljivega odziva, je mogoče zdravilo Sandimmun ukiniti, nadaljnje recidive pa zdraviti s ponovno uvedbo zdravila v odmerku, ki je bil prej učinkovit.
Less than 1% of the administered dose is removed by dialysis. 
Z dializo se izloči manj kot 1 % danega odmerka.
Many side effects associated with ciclosporin therapy are dose-dependent and responsive to dose reduction. 
Številni neželeni učinki ciklosporina so odvisni od odmerka in se odzivajo na znižanje odmerka.
Co-administration of ciclosporin significantly increases blood levels of everolimus and sirolimus. 
Sočasna uporaba ciklosporina pomembno zviša koncentraciji everolimusa in sirolimusa v krvi.
This is because this medicine contains alcohol (see section below “Sandimmun contains ethanol”). 
To je pomembno zato, ker zdravilo vsebuje alkohol (glejte poglavje v nadaljevanju "Zdravilo Sandimmun vsebuje etanol").
Your doctor may give you magnesium supplements to take, especially just after your operation if you have had a transplant. 
Zdravnik vam bo morda svetoval uživanje nadomestkov z magnezijem, zlasti v obdobju takoj po operaciji, če ste prejeli presadek.
Various agents are known to either increase or decrease plasma or whole blood ciclosporin levels usually by inhibition or induction of enzymes involved in the metabolism of ciclosporin, in particular CYP3A4. 
Za različna zdravila je znano, da bodisi zvišajo ali znižajo koncentracijo ciklosporina v plazmi ali polni krvi, običajno tako, da zavirajo ali inducirajo encime, ki sodelujejo pri presnovi ciklosporina, posebno encima CYP3A4.
Sandimmun prevents rejection of transplanted organs by blocking the development of certain cells which would normally attack the transplanted tissue. 
Zdravilo Sandimmun preprečuje zavrnitev presajenega organa tako, da zavira razvoj posebnih celic, ki bi sicer napadle presajeno tkivo.
Elderly population (age 65 years and above) Experience with Sandimmun in the elderly is limited. 
Populacija starejših (starih 65 let ali več) Izkušnje z zdravilom Sandimmun pri starejših bolnikih so omejene.
This is equivalent to nearly 15 ml beer or 5 ml wine per dose. 
Ta količina ustreza približno 15 ml piva oziroma 5 ml vina na odmerek.
PHARMACEUTICAL FORM Concentrate for solution for infusion Clear, brown-yellow oleaginous concentrate. 
FARMACEVTSKA OBLIKA koncentrat za raztopino za infundiranje Bister, rjavo rumen oljni koncentrat.
Keep taking Sandimmun for as long as your doctor tells you. 
Zdravilo Sandimmun jemljite tako dolgo, kot vam naroči zdravnik.
This depends on your body weight and what you are being given the medicine for. 
Odmerek je odvisen od vaše telesne mase in stanja, zaradi katerega prejemate zdravilo.
A 500 mg dose of Sandimmun contains 500 mg ethanol, equivalent to nearly 15 ml beer or 5 ml wine. 
500-miligramski odmerek zdravila Sandimmun vsebuje 500 mg etanola, kar ustreza skoraj 15 ml piva ali 5 ml vina.
Never change your dose yourself, unless a doctor has told you to. 
Odmerka si nikdar ne znižajte sami, če vam tako ne naroči zdravnik.
Neoplasms benign, malignant and unspecified (including cysts and polyps) Patients receiving immunosuppressive therapies, including ciclosporin and ciclosporin containing regimens, are at increased risk of developing lymphomas or lymphoproliferative disorders and other malignancies, particularly of the skin. 
Benigne, maligne in neopredeljene novotvorbe (vključno s cistami in polipi) Pri bolnikih, ki prejemajo imunosupresivno zdravljenje, vključno s ciklosporinom in shemami zdravljenja, ki vsebujejo ciklosporin, obstaja povečano tveganje za razvoj limfoma ali drugih limfoproliferativnih bolezni in drugih malignih bolezni, posebno malignih bolezni kože.
Forced emesis and gastric lavage may be of value within the first few hours after oral intake. 
Izzivanje bruhanja in izpiranje želodca sta lahko koristna v prvih nekaj urah po zaužitju.
Before and during treatment with Sandimmun, tell your doctor straight away: 
Pred in med zdravljenjem z zdravilom Sandimmun morate takoj obvestiti zdravnika:
In patients with nephrotic syndrome treated with immunosuppressants (including ciclosporin), the occurrence of malignancies (including Hodgkin's lymphoma) has occasionally been reported. 
Pri bolnikih z nefrotskim sindromom, zdravljenih z imunosupresivi (vključno s ciklosporinom), so občasno poročali o razvoju malignih bolezni (vključno s Hodgkinovim limfomom).
• Nerve problems with numbness or tingling in fingers and toes. 
• prizadetost živcev z odrevenelostjo ali mravljinčenjem v prstih rok in nog
In the 78-week mouse study, at doses of 1, 4, and 16 mg/kg/day, evidence of a statistically significant trend was found for lymphocytic lymphomas in females, and the incidence of hepatocellular carcinomas in mid-dose males significantly exceeded the control value. 
V raziskavi na miših, ki je trajala 78 tednov in pri kateri so živalim dajali 1, 4 in 16 mg/kg/dan, so ugotovili statistično značilen trend pojavljanja limfocitnega limfoma pri samicah in statistično značilno večjo pogostost pojavljanja hepatocelularnega karcinoma pri samcih, ki so dobivali srednje visoke odmerke, kot v kontrolni skupini.
Prophylactic administration of an antihistamine (H1 + H2 blocker) prior to Sandimmun concentrate for solution for infusion has also been successfully employed to prevent the occurrence of anaphylactoid reactions. 
Tudi s profilaktično uporabo antihistaminikov (antagonistov receptorjev H1 in H2) pred odmerjanjem zdravila Sandimmun koncentrat za raztopino za infundiranje so uspešno preprečevali pojavljanje anafilaktoidnih reakcij.
Since Sandimmun has been reported to induce a reversible slight increase in blood lipids, it is advisable to perform lipid determinations before treatment and after the first month of therapy. 
Poročali so, da zdravilo Sandimmun povzroča manjše reverzibilno zvišanje koncentracije lipidov v krvi, zato je priporočljivo določanje koncentracije lipidov pred zdravljenjem in en mesec po začetku zdravljenja.
Ciclosporin may reduce the clearance of digoxin, colchicine, HMG-CoA reductase inhibitors (statins) and etoposide. 
Ciklosporin lahko zmanjša očistek digoksina, kolchicina, zaviralcev reduktaze HMG-CoA (statinov)
Sandimmun 50 mg/ml concentrate for solution for infusion contains around 34% v/v ethanol (27.8% m/v ethanol). 
Sandimmun 50 mg/ml koncentrat za raztopino za infundiranje vsebuje približno 34 % volumskega deleža etanola (kar je 27,8 % masnega deleža).
For maintenance treatment, doses have to be titrated individually to the lowest effective level, and should not exceed 5 mg/kg/day. 
Za vzdrževalno zdravljenje je treba odmerek pri vsakem posameznem bolniku titrirati do najnižje še učinkovite ravni, pri čemer ne sme presegati 5 mg/kg/dan.
Your doctor will carry out regular blood tests and may change your dose if necessary. 
Zdravnik bo redno izvajal krvne preiskave in vam po potrebi prilagodil odmerek zdravila.
The determination of bilirubin and parameters that assess hepatic function are required prior to starting therapy and close monitoring during treatment is recommended. 
Pred začetkom zdravljenja je treba določiti vrednost bilirubina in parametrov za oceno jetrne funkcije, med zdravljenjem pa je priporočeno skrbno spremljanje navedenih parametrov.
• Serious liver problems both with and without yellowing of the eyes or skin, nausea (feeling sick), loss of appetite, dark coloured urine, swelling of the face, feet, hands and/or the whole body. 
• resne težave z jetri z in brez porumenevanja oči ali kože, z navzeo (občutkom slabosti), z izgubo apetita, s temno obarvanim urinom in z otekanjem v obraz, stopala, roke in/ali celo telo
Rifampicin induces ciclosporin intestinal and liver metabolism. 
Rifampicin inducira presnovo ciklosporina v črevesju in jetrih.
Co-administration of ciclosporin with bosentan is not recommended (see above subsection “Drugs that decrease ciclosporin levels” and section 4.3). 
Sočasna uporaba ciklosporina in bosentana ni priporočena (glejte zgoraj podpoglavje "Zdravila, ki znižujejo koncentracijo ciklosporina" in poglavje 4.3).
It prevents rejection of transplanted organs by blocking the development of certain cells which would normally attack the transplanted tissue. 
Zdravilo preprečuje zavrnitev presajenega organa tako, da zavira razvoj določenih celic, ki bi sicer napadle presajeno tkivo.
It is a potent immunosuppressive agent, which in animals prolongs survival of allogeneic transplants of skin, heart, kidney, pancreas, bone marrow, small intestine or lung. 
To je močno imunosupresivno sredstvo, za katerega so v raziskavah na živalih dokazali, da podaljša preživetje alogenih presadkov kože, srca, ledvic, trebušne slinavke, kostnega mozga, tankega črevesa in pljuč.
In 15 renal transplant patients aged 3 -16 years, ciclosporin whole blood clearance after intravenous administration of Sandimmun was 10.6±3.7 ml/min/kg (assay: Cyclo-trac specific RIA). 
Pri 15 bolnikih s presajeno ledvico, starih 3-16 let, je po intravenskem odmerjanju zdravila Sandimmun znašal očistek ciklosporina iz krvi 10,6±3,7 ml/min/kg (analizna metoda: Cyclo-trac specifičen radioimunski test).
Ciclosporin enhances the risk of hyperkalaemia, especially in patients with renal dysfunction. 
Ciklosporin povečuje tveganje za nastanek hiperkaliemije, zlasti pri bolnikih z okvarjenim delovanjem ledvic.
Pregnancy Animal studies have shown reproductive toxicity in rats and rabbits. 
Študije na živalih so pokazale vpliv na sposobnost razmnoževanja pri podganah in kuncih.
Polyethoxylated castor oil: 650 mg/ml. 
Makrogolglicerol ricinolat: 650 mg/ml.
Combination with products containing Hypericum perforatum (St John´s Wort) (see section 4.5). 
Kombinacija s pripravki, ki vsebujejo Hypericum perforatum (šentjanževko) (glejte poglavje 4.5).
If you take more Sandimmun than you should 
Če ste prejeli večji odmerek zdravila Sandimmun, kot bi smeli
Solid organ transplantation 
Presaditev čvrstih organov
This may be harmful in alcoholic patients and should be taken into account in pregnant or breast-feeding women, in patients presenting with liver disease or epilepsy, or if the patients is a child. 
ki so odvisni od alkohola, pozornost pa je potrebna tudi pri nosečnicah in doječih materah, bolnikih z boleznijo jeter ali epilepsijo in v primeru, da je bolnik še otrok.
Oral doses of ciclosporin of up to 10 g (about 150 mg/kg) have been tolerated with relatively minor clinical consequences, such as vomiting, drowsiness, headache, tachycardia and in a few patients moderately severe, reversible impairment of renal function. 
(približno 150 mg/kg) so ljudje prenašali s sorazmerno malo pomembnimi kliničnimi posledicami, kot so bruhanje, zaspanost, glavobol, tahikardija in pri nekaj bolnikih zmerno huda, reverzibilna okvara delovanja ledvic.
To do this, your doctor may need to do some blood tests. 
V ta namen pa morate opraviti nekaj krvnih preiskav.
It is a clear, yellow to yellow-brownish liquid with a small amount of very fine sediment. 
Bistra rumena do rjavo rumena tekočina z manjšo količino zelo fine usedline.
4.1 Therapeutic indications 
4.1 Terapevtske indikacije Indikacije pri presaditvah
If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 
Če imate dodatna vprašanja o uporabi zdravila, se posvetujte s svojim zdravnikom ali farmacevtom.
The concentrate for solution for infusion contains 50 mg/ml. 
Koncentrat za raztopino za infundiranje vsebuje 50 mg/ml.
Treatment with Sandimmun should be initiated within 12 hours before surgery at a dose of 10 to 15 mg/kg given in 2 divided doses. 
Zdravljenje z zdravilom Sandimmun je treba začeti v roku 12 ur pred kirurškim posegom, in sicer v odmerku 10 do 15 mg/kg v dveh deljenih odmerkih.
Lymphadenopathy which persists despite improvement in disease activity should be examined by biopsy as a precautionary measure to ensure the absence of lymphoma. 
Če limfadenopatija vztraja kljub izboljšanju simptomov bolezni, je zaradi previdnosti potrebna biopsija za potrditev, da ne gre za limfom.
• Excessive hair growth. 
• prekomerna poraščenost
Do not take Sandimmun: 
Ne jemljite zdravila Sandimmun:
If Sandimmun is used to initiate therapy, the recommended daily dose is 12.5 to 15 mg/kg given in 2 divided doses, starting on the day before transplantation. 
Če bolnik za začetno zdravljenje prejema zdravilo Sandimmun, je priporočeni dnevni odmerek 12,5 do 15 mg/kg v dveh deljenih odmerkih, jemati pa naj ga začne en dan pred presaditvijo.
If you get high blood pressure during treatment and it cannot be controlled, Sandimmun should be stopped by your doctor. 
Če med zdravljenjem pride do visokega krvnega tlaka, ki se ga ne da urediti, vam mora zdravnik ukiniti zdravljenje z zdravilom Sandimmun.
Sandimmun oral solution and soft gelatin capsules are bioequivalent. 
Sandimmun peroralna raztopina in mehke želatinske kapsule so med seboj biološko enakovredne.
Administration of ciclosporin 3 hours after lercanidipine yielded no change of the lercanidipine AUC, but the ciclosporin AUC was increased by 27%. 
Pri odmerjanju ciklosporina 3 ure po odmerjanju lerkadipina se AUC lerkadipina ni spremenila, AUC ciklosporina pa se je povečala za 27 %.
The 4-ml syringe is used to measure doses greater than 1 ml and up to 4 ml (each graduation of 0.1 ml corresponds to 10 mg of ciclosporin). 
4-mililitrska brizga je primerna za pripravljanje odmerkov od 1 ml naprej do največ 4 ml (vsaka oznaka za 0,1 ml ustreza 10 mg ciklosporina).
The hepatocellular carcinomas and pancreatic islet cell adenomas were not dose related. 
Hepatocelularni karcinom in adenom pankreasnih otočkov pri poskusnih živalih nista bila odvisna od višine odmerka.
Renal toxicity should be monitored when initiating ciclosporin use together with active substances that increase ciclosporin levels or with substances that exhibit nephrotoxic synergy (see section 4.5). 
Toksično delovanje na ledvice je treba spremljati na začetku uporabe ciklosporina skupaj z učinkovinami, ki zvišujejo koncentracijo ciklosporina, ali s snovmi s sinergističnim toksičnim delovanjem na ledvice (glejte poglavje 4.5).
If you forget to take Sandimmun 
Če ste pozabili vzeti zdravilo Sandimmun
Azitromycin increases ciclosporin levels by around 20%. 
Azitromicin zviša koncentracijo ciklosporina za približno 20 %.
If NSAIDs with a low first-pass effect (e.g. acetylsalicylic acid) are given together with ciclosporin, no increase in their bioavailability is to be expected. 
Pri sočasnem jemanju ciklosporina in nesteroidnih protivnetnih zdravil z majhnim obsegom metabolizma prvega prehoda (na primer acetilsalicilne kisline) ne gre pričakovati povečanja njihove biološke uporabnosti.
Do not stop taking Sandimmun unless your doctor tells you to. 
Ne prenehajte jemati zdravila Sandimmun, razen če vam tako naroči zdravnik.
Sandimmun contains ethanol 
Zdravilo Sandimmun vsebuje etanol
Most reports included patients with significant co-morbidities, underlying conditions and other confounding factors including infectious complications and co-medications with hepatotoxic potential. 
Večina poročil je vključevala bolnike s pomembnimi sočasnimi boleznimi, osnovnimi boleznimi in drugimi begajočimi dejavniki, vključno z zapleti zaradi okužbe in s sočasnim jemanjem zdravil z možnostjo toksičnega delovanja na jetra.
Sandimmun 25 mg soft capsules Sandimmun 50 mg soft capsules Sandimmun 100 mg soft capsules ciclosporin 
Sandimmun 25 mg mehke kapsule Sandimmun 50 mg mehke kapsule Sandimmun 100 mg mehke kapsule ciklosporin
• If you have had an organ transplant, bone marrow and stem cell transplantation, the function of Sandimmun is to control your body's immune system. 
• Če ste prejemnik presajenega organa, kostnega mozga ali presajenih matičnih celic, je naloga zdravila Sandimmun, da zavira imunski sistem vašega organizma.
Treatment of transplant cellular rejection in patients previously receiving other immunosuppressive agents. 
Zdravljenje celičnega zavračanja presadka pri bolnikih, ki so prej že dobivali druga imunosupresivnazdravila.
Special caution is therefore necessary in patients who have previously received preparations containing polyethoxylated castor oil (e.g. a preparation containing Cremophor® EL) by intravenous injection or infusion, and in patients with an allergic predisposition. 
Zato je potrebna posebna pozornost pri bolnikih, ki so že prej prejeli intravensko injekcijo ali infuzijo sredstva, ki vsebuje makrogolglicerol ricinolat (na primer sredstvo, ki vsebuje Cremophor® EL), in pri bolnikih, ki so nagnjeni k alergijskim reakcijam.
What Sandimmun looks like and contents of the pack Sandimmun 25 mg soft capsules are pink and oval. 
Izgled zdravila Sandimmun in vsebina pakiranja Sandimmun 25 mg mehke kapsule so rožnate barve in ovalne oblike.
Within each frequency grouping, adverse drug reactions are presented in order of decreasing seriousness. 
V okviru posamezne kategorije pogostnosti so neželeni učinki navedeni po padajoči resnosti.
The 1-ml syringe is used to measure doses less than or equal to 1 ml (each graduation of 0.05 ml corresponds to 5 mg of ciclosporin). 
1-mililitrska brizga je primerna za pripravljanje odmerkov z volumnom 1 ml ali manj (vsaka oznaka za 0,05 ml ustreza 5 mg ciklosporina).
Treatment of Behçet uveitis with repeated inflammatory attacks involving the retina in patients without neurological manifestations. 
Zdravljenje Behcetovega uveitisa z rekurentnimi vnetji, ki zajemajo mrežnico, pri bolnikih brez nevroloških obolenj.
Effective pre-emptive and therapeutic strategies should be employed, particularly in patients on multiple long-term immunosuppressive therapy. 
Poskrbeti je treba za preventivne in terapevtske ukrepe, še posebno pri bolnikih, ki dolgotrajno prejemajo imunosupresivno zdravljenje z več imunosupresivi.
Prevention of graft rejection following solid organ transplantation. 
Presaditev čvrstih organov Preprečevanje zavračanja presadka po presaditvi čvrstega organa.
Swallow the capsules whole with water. 
Kapsule vzemite iz pretisnega omota in jih pogoltnite cele z nekaj vode.
Special excipients: Ethanol 
Posebne pomožne snovi: etanol
During the concomitant use of a drug that may exhibit nephrotoxic synergy, close monitoring of renal function should be performed. 
Med sočasno uporabo zdravila s sinergističnim toksičnim delovanjem na ledvice je potrebno skrbno spremljanje ledvične funkcije.
Following concomitant administration of ciclosporin and lercanidipine, the AUC of lercanidipine was increased three-fold and the AUC of ciclosporin was increased 21%. 
Pri sočasni uporabi ciklosporina in lerkanidipina se je AUC lerkanidipina trikrat povečala, AUC ciklosporina pa se je povečala za 21 %.
The excretion is primarily biliary, with only 6% of an oral dose excreted in the urine, and with less than 1% in the unchanged form (see sections 4.2 and 4.4). 
Samo 6 % peroralnega odmerka se izloči z urinom in manj kot 1 % v obliki nespremenjenega zdravila (glejte poglavji 4.2 in 4.4).
Drugs that increase ciclosporin levels 
Zdravila, ki zvišujejo koncentracijo ciklosporina
If you stop taking Sandimmun 
Če ste prenehali jemati zdravilo Sandimmun