natgillin/translations-raw huggingface dataset:
When switching from a treatment regimen with an intermediate or long-acting insulin to a regimen with ABASAGLAR, a change of the dose of the basal insulin may be required and the concomitant antidiabetic treatment may need to be adjusted (dose and timing of additional regular insulins or fastacting insulin analogues or the dose of oral antidiabetic medicinal products). 
Pri prehodu s srednjedolgo- ali dolgodelujočega insulina na zdravljenje z zdravilom ABASAGLAR utegneta biti potrebna sprememba odmerka bazalnega insulina in prilagoditev sočasnega antidiabetičnega zdravljenja (odmerek in časovni razpored dodatnih običajnih insulinov ali hitrodelujočih insulinskih analogov oz. odmerek peroralnih antidiabetikov).
ABASAGLAR with alcohol 
- pitje alkohola,
Adolescents and children aged 2 years and older The safety and efficacy of insulin glargine have been established in adolescents and children aged 2 years and older (see section 5.1). 
Varnost in učinkovitost insulina glargin sta bili ugotovljeni pri mladostnikih in otrocih, starih 2 leti in starejših (glejte poglavje 5.1).
The prolonged duration of action of insulin glargine is dependent on its injection into subcutaneous tissue. 
Podaljšano delovanje insulina glargin je povezano s tem, da je injiciran v podkožno tkivo.
Severe allergic reactions (rare, may affect up to 1 in 1,000 people) - the signs may include large-scale skin reactions (rash and itching all over the body), severe swelling of skin or mucous membranes (angiooedema), shortness of breath, a fall in blood pressure with rapid heartbeat and sweating. 
Hude alergijske reakcije (redke, lahko se pojavijo pri največ 1 od 1.000 bolnikov) - znaki lahko vključujejo obsežne kožne reakcije (izpuščaj in srbenje po celem telesu), hudo oteklino kože ali sluznic
Hypoglycaemia (very common), in general the most frequent adverse reaction of insulin therapy, may occur if the insulin dose is too high in relation to the insulin requirement (see section 4.4). 
Hipoglikemija (zelo pogosta), na splošno najpogostejši neželeni učinek zdravljenja z insulinom, se lahko pojavi, če je odmerek insulina prevelik glede na potrebo po insulinu (glejte poglavje 4.4).
Do not store ABASAGLAR next to the freezer compartment or a freezer pack. 
Zdravila ABASAGLAR ne shranjujte v bližini zamrzovalnega razdelka ali zamrzovalnega vložka.
Examples of symptoms that tell you that your blood sugar level is falling too much or too fast: sweating, clammy skin, anxiety, fast heart beat, high blood pressure, palpitations and irregular heartbeat. 
Primeri simptomov, ki vam povedo, da se je krvni sladkor znižal preveč ali prehitro, so: znojenje, vlažna in lepljiva koža, tesnoba, hiter srčni utrip, visok krvni tlak, razbijanje srca in nereden srčni utrip.
In each case, it may be necessary to adjust your insulin dose to avoid blood sugar levels that are either too low or too high. 
V vsakem primeru utegne biti potrebna prilagoditev odmerka insulina, da bi se izognili prenizki ali previsoki koncentraciji krvnega sladkorja.
Factors increasing the susceptibility to hypoglycaemia require particularly close monitoring and may necessitate dose adjustment. 
V primeru dejavnikov, ki povečujejo nagnjenost k hipoglikemiji, mora biti nadzor posebej natančen; potrebna utegne biti prilagoditev odmerka.
Problems with the insulin pen? 
Imate težave z insulinskim peresnikom?
Based on your life-style and the results of your blood sugar (glucose) tests and your previous insulin usage, your doctor will: 
Vaš zdravnik bo, glede na vaš način življenja, izvide meritev vašega krvnega sladkorja (glukoze) in prejšnjo uporabo insulina:
How to recognise your ABASAGLAR KwikPen: 
Kako prepoznati peresnik ABASAGLAR KwikPen:
The ORIGIN (Outcome Reduction with Initial Glargine INtervention) study was a multicenter, randomised, 2x2 factorial design study conducted in 12,537 participants at high cardiovascular (CV) risk with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) (12% of participants) or type 2 diabetes mellitus treated with ≤1 antidiabetic oral agent (88% of participants). 
Študija ORIGIN (izboljšanje izida z začetnim dajanjem glargina) je bila multicentrična, randomizirana študija s faktorskim načrtom, opravljena na 12.537 preiskovancih z velikim srčno-žilnim (SŽ) tveganjem z moteno glukozo na tešče (IFG) ali moteno glukozno toleranco (IGT) (12 % preiskovancev) ali diabetesom tipa 2, zdravljenim z ≤1 peroralnim antidiabetikom (88 %
The signs may include reddening, unusually intense pain when injecting, itching, hives, swelling or inflammation. 
Znaki lahko vključujejo pordelost, nenavadno močno bolečino pri injiciranju, srbenje, koprivnico, otekanje ali vnetje.
If your blood sugar is too low (hypoglycaemia), follow the guidance for hypoglycaemia (see box at the end of this leaflet). 
Če imate prenizek krvni sladkor (hipoglikemijo), upoštevajte navodila za ravnanje v primeru hipoglikemije (glejte okvir na koncu tega navodila).
KwikPen Multipack: 10 (2 packs of 5) pens of 3 mL. 
Peresnik KwikPen Večje pakiranje: 10 (2 x 5) peresnikov po 3 ml
The prolonged effect of subcutaneous insulin glargine may delay recovery from hypoglycaemia. 
Podaljšani učinek subkutanega insulina glargin lahko upočasni okrevanje po hipoglikemiji.
The instructions for using the pen must be followed carefully for loading the cartridge, attaching the needle, and administering the insulin injection. 
Navodila za uporabo peresnika morate natančno upoštevati, ko vstavljate vložek, pritrjujete iglo in dajete injekcijo insulina.
With improved metabolic control and resulting increase in insulin sensitivity a further adjustment in dose regimen may become necessary. 
Zaradi boljše urejenosti presnove in večje občutljivosti za insulin utegne biti potrebna nadaljnja prilagoditev odmerka.
You may need to talk about: - the availability of your insulin in the country you are visiting, - supplies of insulin etc. 
Med vprašanji, o katerih se boste morali pogovoriti, so: - dosegljivost vašega insulina v državi, v katero se odpravljate, - zaloge insulina itd., - pravilno shranjevanje insulina med potovanjem,
Beta-blockers, clonidine, lithium salts or alcohol may either potentiate or weaken the blood-glucose lowering effect of insulin. 
Zaviralci adrenergičnih receptorjev beta, klonidin, litijeve soli ali alkohol lahko učinek znižanja glukoze v krvi pri insulinu bodisi stopnjujejo ali oslabijo.
These cartridges are for use with a Lilly 3 mL pen only. 
Ti vložki so namenjeni izključno uporabi s 3-ml peresnikom Lilly.
Injection sites must be rotated within a given injection area from one injection to the next. 
Mesto injiciranja na posameznem predelu je treba od injekcije do injekcije krožno menjati.
The rates of severe hypoglycaemia (affected participants per 100 participant years of exposure) were 1.05 for insulin glargine and 0.30 for standard care group and the rates of confirmed non-severe hypoglycaemia were 7.71 for insulin glargine and 2.44 for standard care group. 
udeleženskih let izpostavljenosti) sta bili 1,05 v skupini z insulinom glargin in 0,30 v skupini s standardnim zdravljenjem, stopnji potrjene hipoglikemije, ki ni bila huda, pa sta bili 7,71 v skupini z insulinom glargin in 2,44 v skupini s stanrdadnim zdravljenjem.
• Wipe the rubber seal with a swab. 
• Gumijasto zaporko obrišite z zložencem.
• Change (rotate) your injection site for each injection. 
• Za vsako injiciranje spremenite (rotirajte) mesto injiciranja.
Do not dilute it. Mixing or diluting may change the action of ABASAGLAR. 
Ne redčite ga. Mešanje ali redčenje lahko spremeni delovanje zdravila ABASAGLAR.
Do not use if it is cloudy, coloured, or has particles or clumps in it. 
Ne uporabljajte zdravila, če je motno, obarvano ali če vsebuje delce ali grudice.
In vitro studies indicate that the affinity of insulin glargine and its metabolites M1 and M2 for the human insulin receptor is similar to the one of human insulin. 
Študije in vitro kažejo, da je afiniteta insulina glargina in njegovih presnovkov M1 in M2 za človeške insulinske receptorje podobna afiniteti humanega insulina.
• To prime your pen, turn the dose knob to select 2 units. 
• Zavrtite gumb za odmerjanje tako, da izberete 2 enoti.
Monitor your blood glucose as instructed by your healthcare professional. 
Spremljajte raven glukoze v krvi, kot vam je naročil zdravnik.
How to handle ABASAGLAR KwikPen 
Kako ravnati s peresnikom ABASAGLAR KwikPen
In patients with hepatic impairment, insulin requirements may be diminished due to reduced capacity for gluconeogenesis and reduced insulin metabolism. 
Bolnikom z okvaro jeter se lahko potreba po insulinu zmanjša zaradi zmanjšane zmožnosti za glukoneogenezo in zmanjšane presnove insulina.
Treatment of diabetes mellitus in adults, adolescents and children aged 2 years and above. 
Zdravljenje diabetesa mellitusa pri odraslih, mladostnikih in otrocih, starih 2 leti in več.
The instructions for using the insulin pen are provided with your insulin pen. 
Navodila za uporabo insulinskega peresnika so priložena vašemu insulinskemu peresniku.
How to use ABASAGLAR 
Kako uporabljati zdravilo ABASAGLAR
ABASAGLAR is available in packs containing 5 pre-filled pens and in multipacks comprising 2 cartons, each containing 5 pre-filled pens. 
Na voljo so pakiranja po 5 napolnjenih peresnikov in večja pakiranja , ki vsebujejo 2 pakiranji, eno pakiranje vsebuje 5 napolnjenih peresnikov.
The primary activity of insulin, including insulin glargine, is regulation of glucose metabolism. 
Temeljno delovanje insulina, tudi insulina glargin, je uravnavanje presnove glukoze.
No metabolic effects of ingested insulin glargine on the breast-fed newborn/infant are anticipated since insulin glargine as a peptide is digested into amino acids in the human gastrointestinal tract. 
Presnovnih učinkov zaužitega insulina glargin na dojenega novorojenčka/dojenčka ni pričakovati, ker se insulin glargin kot peptid v človeških prebavilih prebavi v aminokisline.
Cases of cardiac failure have been reported when pioglitazone was used in combination with insulin, especially in patients with risk factors for development of cardiac heart failure. 
Pri uporabi kombinacije pioglitazona in inzulina poročajo o primerih srčnega popuščanja, predvsem pri bolnikih z dejavniki tveganja za razvoj srčnega popuščanja.
Serious hypoglycaemia may cause brain damage and may be life-threatening. 
Huda hipoglikemija lahko povzroči poškodbo možganov in je lahko smrtno nevarna.
If you think you may have a problem with ABASAGLAR KwikPen, consult your doctor, pharmacist or nurse. 
Če se vam zdi, da imate težave s peresnikom ABASAGLAR KwikPen, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
Make sure that neither alcohol nor other disinfectants or other substances contaminate the insulin. 
Poskrbeti morate, da insulina ne bodo onesnažili alkohol, druga dezinfekcijska sredstva ali kakšne druge snovi.
A number of substances affect glucose metabolism and may require dose adjustment of insulin glargine. 
Na presnovo glukoze vplivajo številna zdravila in potrebna utegne biti prilagoditev odmerka insulina glargin.
Switch from twice daily NPH insulin to ABASAGLAR To reduce the risk of nocturnal and early morning hypoglycaemia, patients who are changing their basal insulin regimen from a twice daily NPH insulin to a once daily regimen with ABASAGLAR should reduce their daily dose of basal insulin by 20-30 % during the first weeks of treatment. 
Prehod z insulina NPH dvakrat na dan na zdravilo ABASAGLAR Bolniki, ki z insulina NPH dvakrat na dan preidejo na zdravilo ABASAGLAR enkrat na dan, morajo za zmanjšanje nevarnosti nočne in zgodnje jutranje hipoglikemije dnevni odmerek bazalnega insulina v prvih tednih zdravljenja zmanjšati za 20 do 30%.
• Unscrew the capped needle and dispose of it as directed by your healthcare professional. 
Odvijte iglo s pokrovčkom in jo zavrzite v skladu z navodili vašega zdravstvenega delavca.
Dose Knob with green ring 
Gumb za odmerjanje z zelenim obročem
ABASAGLAR"). 
preiskovancev).
• Push the capped needle straight onto the pen and twist the needle on until it is tight. 
• Potisnite iglo s pokrovčkom naravnost v peresnik in trdno privijte iglo.
Lipodystrophy may occur at the injection site and delay local insulin absorption. 
Na injekcijskem mestu se lahko pojavi lipodistrofija in upočasni lokalno absorpcijo insulina.
Solution for injection (injection) in pre-filled pen (KwikPen) Clear, colourless solution. 
raztopina za injiciranje (injekcija) v napolnjenem injekcijskem peresniku (KwikPen) Bistra, brezbarvna raztopina.
For more information, see the box at the end of this leaflet. 
Za več informacij glejte okvir na koncu tega navodila za uporabo.
- The other ingredients are: zinc oxide, metacresol, glycerol, sodium hydroxide (see section 2 “Important information about some of the ingredients of ABASAGLAR”), hydrochloric acid and water for injections. 
- Druge sestavine zdravila so: cinkov oksid, metakrezol, glicerol, natrijev hidroksid (glejte poglavje 2 "Pomembne informacije o nekaterih sestavinah zdravila ABASAGLAR"), klorovodikova kislina in voda za injekcije.
ABASAGLAR KwikPen is a pre-filled disposable pen containing insulin glargine. 
ABASAGLAR KwikPen je napolnjen peresnik za enkratno uporabo, ki vsebuje insulin glargin.
ABASAGLAR should not be administered intravenously. 
Zdravila ABASAGLAR se ne sme dajati intravensko.
A marked change in glycaemic control may cause temporary visual impairment, due to temporary alteration in the turgidity and refractive index of the lens. 
Izrazita sprememba glikemične urejenosti lahko prehodno poslabša vid zaradi prehodno spremenjenega turgorja in lomnega količnika leče.
Rare side effects (may affect up to 1 in 1,000 people) 
Redko poročani neželeni učinki (pojavijo se lahko pri največ 1 od 1.000 bolnikov)
Do not stop ABASAGLAR without speaking to a doctor, who will tell you what needs to be done. 
ABASAGLAR, ne da bi se pogovorili z zdravnikom.
Tap the cartridge holder gently to collect air bubbles at the top. 
Nežno potrepljajte držalo vložka, tako da se bodo zračni mehurčki nabrali na vrhu.
No new safety signals were seen during this extended treatment with insulin glargine. 
Med tem podaljšanim zdravljenjem z insulinom glargin niso odkrili nobenih novih varnostnih signalov.
• ABASAGLAR KwikPen 
• Peresnik ABASAGLAR KwikPen
ABASAGLAR is administered subcutaneously. 
Zdravilo ABASAGLAR se daje subkutano.
ABASAGLAR contains insulin glargine, an insulin analogue and has a prolonged duration of action. 
Zdravilo ABASAGLAR vsebuje insulin glargin, insulinski analog s podaljšanim delovanjem.
The pen should be used as recommended in the information provided with the device. 
Peresnik morate uporabljati, kot je priporočeno v informacijah, priloženih pripomočku.
Lipohypertrophy 
Lipohipertrofija
Insulin glargine has a long and steady blood-sugar-lowering action. 
Insulin glargin znižuje krvni sladkor dolgo in enakomerno.
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity to reproduction. 
Predklinični podatki na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih se odmerkih, genotoksičnosti, kancerogenega potenciala in vpliva na sposobnost razmnoževanja ne kažejo posebnega tveganja za človeka.
Refer to the instructions for using the pen. 
Glejte navodila za uporabo peresnika.
To reduce the risk of hypoglycemia, patients who are changing their basal insulin regimen from an insulin regimen with once daily insulin glargine 300 units/ml to a once daily regimen with ABASAGLAR should reduce their dose by approximately 20%. 
Bolniki, ki spremenijo svoj režim z bazalnim insulinom tako, da z insulina glargina 300 enot/ml enkrat na dan preidejo na zdravilo ABASAGLAR enkrat na dan, morajo za zmanjšanje nevarnosti hipoglikemije svoj odmerek insulina zmanjšati za približno 20%.
Do not refrigerate or freeze. 
Ne shranjujte v hladilniku in ne zamrzujte.
Effects of insulin glargine (once daily) on diabetic retinopathy were evaluated in an open-label 5 year NPH-controlled study (NPH given bid) in 1024 type 2 diabetic patients in which progression of retinopathy by 3 or more steps on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale was investigated by fundus photography. 
kontrolirani študiji (NPH apliciran dvakrat na dan) pri 1.024 bolnikih z diabetesom tipa 2, pri katerih so napredek retinopatije za tri ali več stopenj po lestvici ETDRS (Early Treatment Diabetic Retinopathy Study) preiskovali s slikanjem očesnega ozadja.
Beta-blockers like other sympatholytic medicines (such as clonidine, guanethidine, and reserpine) may weaken or suppress entirely the first warning symptoms which help you to recognise a hypoglycaemia. 
Zaviralci adrenergičnih receptorjev beta lahko, tako kot druga simpatikolitična zdravila (kot so klonidin, gvanetidin in reserpin), oslabijo ali popolnoma preprečijo prve opozorilne simptome, ki vam pomagajo prepoznati hipoglikemijo.
- inject the amount left in your pen and then use a new pen to give the rest of your dose, or 
- injicirate preostalo količino insulina iz peresnika, nato pa za dajanje preostanka svojega odmerka uporabite nov peresnik, ali pa - vzamete nov peresnik in si injicirate celoten odmerek.
• Do not freeze ABASAGLAR. 
• Ne zamrzujte zdravila ABASAGLAR.
Examples include: - you inject too much insulin, - you miss meals or delay them, - you do not eat enough, or eat food containing less carbohydrate than normal (sugar and substances similar to sugar are called carbohydrates; however, artificial sweeteners are NOT 
- izpustite obroke ali jih imate prepozno, - ne jeste dovolj ali uživate hrano, ki vsebuje manj ogljikovih hidratov kot normalno (sladkor in sladkorju podobne snovi imenujemo ogljikovi hidrati; toda umetna sladila NISO ogljikovi hidrati), - izgubljate ogljikove hidrate zaradi bruhanja ali driske,
Patients with high insulin doses because of antibodies to human insulin may experience an improved insulin response with ABASAGLAR. 
Pri bolnikih, ki zaradi protiteles proti humanemu insulinu potrebujejo velike odmerke insulina, se lahko pri jemanju zdravila ABASAGLAR odziv na insulin izboljša.
Read carefully the "ABASAGLAR KwikPen Instructions for Use" included with this package leaflet. 
Natančno preberite Navodila za uporabo peresnika ABASAGLAR KwikPen, ki so vključena v to navodilo.
Disposing of pens and needles 
Odlaganje peresnikov in igel
Tell a doctor straight away if you notice signs of severe allergic reaction. 
Če opazite znake hude alergijske reakcije, takoj obvestite zdravnika.
Cartridges in use (in the insulin pen) or carried as a spare may be stored for a maximum of 28 days up to 30°C and away from direct heat or direct light. 
Vložki, ki so v uporabi Vložke v uporabi (v insulinskem peresniku) ali vložke, ki jih imate pri sebi za rezervo, lahko shranjujete največ 28 dni pri temperaturi do 30 °C in zaščitene pred neposredno toploto in svetlobo.
You can give yourself multiple doses using one pen. 
Z uporabo enega peresnika si lahko date več odmerkov.
At the last on-treatment visit, there was a mean increase in body weight from baseline of 1.4 kg in the insulin glargine group and a mean decrease of 0.8 kg in the standard care group. 
Ob zadnjem obisku med zdravljenjem se je telesna masa od izhodišča v skupini z insulinom glargin povprečno povečala za 1,4 kg, in v skupini s standardnim zdravljenjem povprečno zmanjšala za
In clinical pharmacology studies, intravenous insulin glargine and human insulin have been shown to be equipotent when given at the same doses. 
Klinične farmakološke študije so dokazale, da sta intravensko uporabljena insulin glargin in humani insulin v enakih odmerkih ekvipotentna.
Packs of 5 pens and multipacks containing 10 (2 packs of 5) pens . 
Na voljo so pakiranja po 5 peresnikov in večja pakiranja, ki vsebujejo 10 peresnikov (2 pakiranji po 5
Shelf life after first use 
Rok uporabnosti po prvi uporabi
Close metabolic monitoring is recommended during the switch and in the initial weeks thereafter. 
Med prehodom in v prvih tednih po njem je potreben natančen nadzor presnove.
• Priming your pen means removing the air from the needle and cartridge that may collect during normal use and ensures that the pen is working correctly. 
• Aktivacija zagotovi, da je peresnik pripravljen za uporabo in odstrani zrak, ki se lahko nabere v vložku pri običajni uporabi.
The patient should be advised to read the instructions for use included in the package leaflet carefully before using ABASAGLAR solution for injection in pre-filled pen. 
Bolnikom je treba svetovati, naj pred uporabo zdravila ABASAGLAR raztopina za injiciranje v napolnjenem injekcijskem peresniku natančno preberejo navodila za uporabo na vloženem lističu.
If you think you may have a problem with ABASAGLAR, have it checked by your doctor or pharmacist. 
Če se vam zdi, da imate težave z zdravilom ABASAGLAR, naj ga pregleda vaš zdravnik ali farmacevt.
The ABASAGLAR cartridges are to be used only in conjunction with a Lilly reusable insulin pen (see section 4.4). 
Insulinski peresnik Vložke ABASAGLAR lahko uporabljate samo skupaj z insulinskim injekcijskim peresnikom Lilly za večkratno uporabo (glejte poglavje 4.4).
What ABASAGLAR looks like and contents of the pack 
Izgled zdravila ABASAGLAR in vsebina pakiranja
• Select a new needle. 
Izberite novo iglo.
Insulin administration may cause insulin antibodies to form. 
Uporaba insulina lahko povzroči nastanek insulinskih protiteles.
Medication errors have been reported in which other insulins, particularly short-acting insulins, have been accidentally administered instead of insulin glargine. 
O napakah zdravljenja so poročali, ko so bili drugi insulini, posebno kratko delujoči insulini,
It is completely soluble at the acidic pH of the ABASAGLAR injection solution (pH 4). 
Pri kislem pH raztopine za injiciranje zdravila ABASAGLAR (pH 4) pa je popolnoma topen.
Pens in use must not be stored in the refrigerator. 
Vložkov, ki jih uporabljate, ne smete shranjevati v hladilniku.
Preparing your Pen 
Priprava vašega peresnika
The pen cap must be put back on the pen after each injection in order to protect from light. 
Pokrovček peresnika morate po vsakem injiciranju namestiti nazaj na peresnik, da ga zaščitite pred svetlobo.
ABASAGLAR is used to treat diabetes mellitus in adults, adolescents and children aged 2 years and above. 
Zdravilo ABASAGLAR se uporablja za zdravljenje sladkorne bolezni pri odraslih, mladostnikih in otrocih, starih 2 leti in več.
Read all of this leaflet carefully including the Instructions for Use of the ABASAGLAR KwikPen pre-filled pen, before you start using this medicine because it contains important information for you. 
Pred začetkom uporabe zdravila natančno in v celoti preberite to navodilo, vključno z Navodili za uporabo napolnjenega injekcijskega peresnika ABASAGLAR KwikPen, ker vsebuje za vas pomembne podatke.
Substances that may enhance the blood-glucose-lowering effect and increase susceptibility to hypoglycaemia include oral antidiabetic medicinal products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase (MAO) inhibitors, pentoxifylline, propoxyphene, salicylates, somatostatin anologues and sulphonamide antibiotics. 
Med zdravili, ki lahko stopnjujejo učinek znižanja glukoze v krvi in povečajo nagnjenost k hipoglikemiji, so peroralni antidiabetiki, zaviralci angiotenzinske konvertaze (ACE), dizopiramid, fibrati, fluoksetin, zaviralci monoaminooksidaze (MAO), pentoksifilin, propoksifen, salicilati, analogi somatostatina in sulfonamidni antibiotiki.
Physiological concentrations of endogenous IGF-1 may activate the mitogenicproliferative pathway; however, the therapeutic concentrations found in insulin therapy, including in ABASAGLAR therapy, are considerably lower than the pharmacological concentrations required to activate the IGF-1 pathway. 
Vendar so terapevtske koncentracije med insulinskim zdravljenjem, vključno z zdravljenjem z zdravilom ABASAGLAR, bistveno manjše kot farmakološke koncentracije, potrebne za aktivacijo poti IGF-1.