natgillin/translations-raw huggingface dataset:
After oral administration of 50 mg the mean Cmax =21.5±9.0 ng/ml; range 13.2-35.8 ng/ml (77.5±32.4 nmol/L).> 
Po peroralni aplikaciji 50 mg je povprečna Cmax = 21,5 ± 9,0 ng/ml; razpon 13,2 - 35,8 ng/ml (77,5 ± 32,4 nmol/l).>
Doses can be increased with 10 mg - 25 mg every 3 - 7 days as tolerated. 
Odmerke je mogoče povečati po 10 mg ali 25 mg na vsake 3 do 7 dni, kot jih bolnik prenaša.
Amitriptyline for enuresis should not be combined with an anticholinergic drug. 
Za zdravljenje enureze amitriptilina ni dovoljeno kombinirati z drugimi antiholinergiki.
The score line facilitates breaking of the retard tablet into 3 parts. 
Razdelilna zareza olajša lomljenje tablete s podaljšanim sproščanjem na 3 dele.
If you have any further questions on the use of this product, ask your doctor or pharmacist. 
Če imate dodatna vprašanja o uporabi tega zdravila, se posvetujte z zdravnikom ali farmacevtom.
• if you have heart problems such as disturbances in heart rhythm which are seen on an electrocardiogram (ECG), heart block, or coronary artery disease 
• če imate težave s srcem, kot so motnje srčnega ritma, kar je vidno na elektrokardiogramu
Dose to be administered 1-1½ hours before bedtime. 
Odmerek je treba dati 1 - 1,5 ure pred spanjem.
METHOD OF ADMINISTRATION Solution for i.v. 
POSTOPEK UPORABE raztopina za i.v.
After peroral administration of 50 mg the mean Cmax = 30.95±9.61 ng/ml; range 10.85-45.70 ng/ml (111.57±34.64 nmol/l; range 39.06-164.52 nmol/l). 
Po peroralni aplikaciji 50 mg je povprečna Cmax = 30,95 ± 9,61 ng/ml; razpon 10,85 - 45,70 ng/ml (111,57 ± 34,64 nmol/l; razpon 39,06164,52 nmol/l).
The recommended initial dose is 50 mg in the evening. 
Priporočeni začetni odmerek je 50 mg zvečer.
The antidepressant effect usually sets in after 2-4 weeks; the sedative action is not delayed. 
Antidepresivni učinek običajno nastopi po 2 do 4 tednih; sedativno delovanje ni zakasnjeno.
Anticholinergic agents: Tricyclic antidepressants may potentiate the effects of these drugs on the eye, central nervous system, bowel and bladder; concomitant use of these should be avoided due to an increased risk of paralytic ileus, hyperpyrexia, etc. 
Antiholinergična zdravila: Triciklični antidepresivi lahko okrepijo učinke teh zdravil na oko, osrednje živčevje, črevesje in mehur; sočasni uporabi se je treba izogibati zaradi povečanega tveganja za paralitični ileus, hiperpireksijo itd.
• aged 11 years and above: 25 mg - 50 mg. 
• stare 11 let in več: 25 mg - 50 mg.
If you have any further questions on the use of this prodcut, ask your doctor, pharmacist or nurse. 
Če imate dodatna vprašanja o uporabi tega zdravila, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
The noradrenaline, sodium and the NMDA effects are mechanisms known to be involved in the maintenance of neuropathic pain, chronic tension type headache prophylaxis and migraine prophylaxis. 
Za noradrenalin, natrij in NMDA je znano, da sodelujejo pri vzdrževanju nevropatske bolečine, preprečevanju kroničnega glavobola tenzijskega tipa in preprečevanju migrene.
An increased risk of bone fractures has been observed in patients taking this type of medicines. 
Pri bolnikih, ki so jemali to vrsto zdravil, so opazili povečano tveganje za zlome kosti.
• thioridazine (used to treat schizophrenia) 
• tioridazin (uporablja se za zdravljenje shizofrenije)
Weakened patients, patients with cerebral or cardiac impairment, as well as patients with poor circulation, breathing problems, impaired liver function or advanced renal impairment a dose reduction is recommended. 
Bolniki s posebnimi dejavniki tveganji Pri oslabelih, bolnikih z možgansko ali srčno okvaro in pri bolnikih s slabo prekrvavitvijo, težavami z dihanjem, okvaro jeter ali napredovalo okvaro ledvic se priporoča zmanjšanje odmerka.
• children aged 11 years and above: 25 mg - 50 mg daily 
• otroci, stari 11 let in več: 25 mg - 50 mg na dan
Bone marrow depression, agranulocytosis, leucopenia, eosinophilia, thrombocytopenia. 
Bolezni krvi in limfatičnega sistema redki depresija kostnega mozga, agranulocitoza, levkopenija, eozinofilija, trombocitopenija.
• the treatment of neuropathic pain in adults 
• zdravljenje nevropatske bolečine pri odraslih
Common (> 1/100, < 1/10); 
Pogosti (> 1/100, < 1/10);
Amitriptyline should be used with caution in patients receiving SSRIs (see sections 4.2 and 4.5). 
Pri bolnikih, ki prejemajo selektivne zaviralce ponovnega privzema serotonina, je treba amitriptilin uporabljati previdno (glejte poglavji 4.2 in 4.5).
Children are especially susceptible to cardiotoxicity and seizures. 
Za kardiotoksičnost in epileptične napade so dovzetni predvsem otroci.
Other isozymes involved in the metabolism of amitriptyline are CYP3A4, CYP1A2 and CYP2C9. 
Drugi izoencimi, ki sodelujejo pri presnovi amitriptilina, so CYP3A4, CYP1A2 in CYP2C9.
When stopping therapy the drug should be gradually withdrawn during several weeks. 
Pri prenehanju zdravljenja je treba odmerek zdravila zmanjševati postopno več tednov.
• ritonavir (used to treat HIV) 
• ritonavir (uporablja se za zdravljenje okužb z virusom HIV)
Other Cytochrome P450 inhibitors: Cimetidine, methylphenidate and calcium-channel blockers (e.g. diltiazem and verapamil) may increase plasma levels of tricyclic antidepressants and accompanying toxicity. 
Drugi zaviralci citokroma P450: Cimetidin, metilfenidat in zaviralci kalcijevih kanalčkov (npr. diltiazem in verapamil) lahko povečajo ravni tricikličnih antidepresivov v plazmi in posledično njihovo toksičnost.
If you were given more X then you should 
Če ste dobili večji odmerek zdravila X, kot bi smeli
• aged 6 to 10 years: 10 mg - 20 mg daily. 
• stare od 6 do 10 let: 10 mg - 20 mg na dan.
<[Saroten and associated names 75 mg, modified release tablets] When the modified-release tablets are administered in the evening the concentration of amitriptyline is highest late in the night and decreases during the day whilst the concentration of nortriptyline is constant around the clock and thus predominates during daytime.> 
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem] Pri dajanju tablet s prirejenim sproščanjem zvečer je koncentracija amitriptilina največja pozno ponoči, nato pa se čez dan zmanjšuje, medtem ko je koncentracija nortriptilina konstantna 24 ur in prevladuje tekom dneva.>
• schizophrenia 
• shizofrenijo
Any degree of heart block or disorders of cardiac rhythm and coronary artery insufficiency. 
Nedavno preboleli miokardni infarkt; katera koli stopnja srčnega bloka ali motnje srčnega ritma in koronarna insuficienca.
The daily dosage is in general between 1and 3 ampoules of 2 ml (equivalent to 50-150 mg amitriptyline hydrochloride/day). 
Dnevni odmerek je običajno 1 do 3 ampule po 2 ml (kar ustreza 50 - 150 mg amitriptilinijevega klorida na dan).
Close supervision of patients and in particular those at high risk should accompany drug therapy especially in early treatment and following dose changes. 
Pri zdravljenju s tem zdravilom je treba na začetku in po spremembah odmerka bolnike skrbno nadzorovati, predvsem tiste, pri katerih obstaja veliko tveganje.
The metabolism is subject to genetic polymorphism (CYP2D6 and CYP2C19) (see section 4.2). 
Presnova je odvisna od genetskega polimorfizma (CYP2D6 in CYP2C19) (glejte poglavje 4.2).
Cases of QT interval prolongation and arrhythmia have been reported during the post-marketing period. 
V obdobju trženja so poročali o podaljšanju intervala QT in aritmijah.
Secure an IV access. 
Zagotovitev i.v.
This medical product should be used with caution in patients with convulsive disorders, urinary retention, prostatic hypertrophy, hyperthyroidism, paranoid symptomatology and advanced hepatic or cardiovascular disease, pylorus stenosis and paralytic ileus. 
Bolniki s konvulzijami, zastojem seča, hipertrofijo prostate, hipertiroidizmom, paranoidnimi simptomi in napredovalo boleznijo jeter ali srčno-žilno boleznijo, stenozo pilorusa in paralitičnim ileusom morajo to zdravilo uporabljati previdno.
Drugs which prolong the QT-interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide and sertindole), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants. 
Zdravila, ki podaljšajo interval QT, vključno z antiaritmiki, kot je kinidin, antihistaminikoma astemizolom in terfenadinom, nekaterimi antipsihotiki (zlasti pimozid in sertindol), cisaprid,
- Attacks of intermittent blurring of vision, rainbow vision, and eye pain. 
• izmenični napadi zamegljenega vida, mavrični krogi okrog izvorov svetlobe in bolečine v očesu
• abnormality in the heart's rhythm, or heartbeat pattern 
• nenormalen srčni ritem ali srčni utrip
Doses above 100 mg should be used with caution. 
Odmerke, večje od 100 mg, je treba uporabljati previdno.
• monoamine oxidase inhibitors (MAOIs) e.g. phenelzine, iproniazid, isocarboxazid, nialamide or tranylcypromine (used to treat depression) or selegiline (used to treat Parkinson's disease). 
• zaviralci monoaminooksidaze npr. fenelzin, iproniazid, izokarboksazid, nialamid ali tranilcipromin (uporabljajo se za zdravljenje depresije) ali selegilin (uporablja se za zdravljenje Parkinsonove bolezni).
Not known Hepatitis. 
neznana pogostnost hepatitis
Consider gastric lavage only if within one hour of a potentially fatal overdose. 
Izpiranje želodca je smiselno opraviti le v prvi uri prevelikega odmerka, ki je lahko smrten.
• cimetidine (used to treat stomach ulcers) 
• cimetidin (uporablja se za zdravljenje želodčnih razjed)
In vitro the metabolism of amitriptyline proceeds mainly by demethylation (CYP2C19, CYP3A) and hydroxylation (CYP2D6) followed by conjugation with glucuronic acid. 
Presnova amitriptilina in vitro poteka pretežno z demetilacijo (CYP2C19, CYP3A) in hidroksilacijo (CYP2D6), katerima sledi konjugacija z glukuronsko kislino.
Treatment of the following will be decided on a case by case basis: - Wide QRS-intervals, cardiac failure and ventricular arrhythmias - Circulatory failure - Hypotension - Hyperthermia - Convulsions - Metabolic acidosis. 
Zdravljenje naslednjih stanj se razlikuje od primera do primera: - razširjeni interval QT, srčna odpoved in ventrikualrne aritmije - cirkulatorni kolaps - hipotenzija - hipertermija - konvulzije - metabolna acidoza
• if you have taken MAOIs within the last 14 days 
• če ste v zadnjih 14 dneh jemali zaviralce monoaminooksidaze
Polymorphism The metabolism is subject to genetic polymorphism (CYP2D6 and CYP2C19) (see section 4.2). 
Polimorfizem Presnova je odvisna od genetskega polimorfizma (CYP2D6 in CYP2C19) (glejte poglavje 4.2).
Suicidal thoughts and behaviours may also develop during early treatment with antidepressants for disorders other than depression; the same precautions observed when treating patients with depression should therefore be followed when treating patients with enuresis. 
V zgodnjem obdobju zdravljenja z antidepresivi za druge motnje kot depresijo se lahko pojavijo samomorilne misli in samomorilno vedenje, zato je treba pri zdravljenju bolnikov z enurezo upoštevati enake previdnostne ukrepe kot pri zdravljenju bolnikov z depresijo.
In vitro the metabolism of amitriptyline proceeds mainly by demethylation (CYP2C19, CYP3A4) and hydroxylation (CYP2D6) followed by conjugation with glucuronic acid. 
Presnova amitriptilina in vitro poteka pretežno z demetilacijo (CYP2C19, CYP3A4) in hidroksilacijo (CYP2D6), katerima sledi konjugacija z glukuronsko kislino.
• uncontrolled movements 
• nenadzorovane gibe
Unless prescribed otherwise adults will receive half an ampoule up to 2 ampoules (1 to 4 ml solution for injection, equivalent to 25 to 100 mg amitriptyline hydrochloride per day) in several single injections of no more than 25 mg amitriptyline hydrochloride. 
Če ni predpisano drugače, prejme odrasel bolnik od pol ampule do 2 ampuli (1 do 4 ml raztopine za injiciranje, kar ustreza od 25 do 100 mg amitriptilinijevega klorida na dan) v več posameznih injekcijah po največ 25 mg amitriptilinijevega klorida.
• medicines to treat irregular heartbeats (e.g. quinidine and sotalol) 
• zdravila za zdravljenje nepravilnega bitja srca (npr. kinidin in sotalol)
• movement disorders (involuntary movements or decreased movements) 
• motnje gibanja (nehoteni gibi ali zmanjšano gibanje)
Not known Anorexia, elevation or lowering of blood sugar levels. 
Presnovne in prehranske motnje redki zmanjšan apetit neznana pogostnost anoreksija, zvišanje ali znižanje ravni krvnega sladkorja
The dosing scheme and treatment duration given for the oral formulation should be followed from henceforward. 
V tem obdobju je treba upoštevati shemo odmerjanja in trajanje zdravljenja za peroralno obliko.
Reduced renal function This medicinal product can be given in usual doses to patients with renal failure. 
To zdravilo se lahko bolnikom z ledvično odpovedjo daje v običajnih odmerkih.
If you receive doses above 75 mg daily, your doctor may need to do more frequent follow-up with you. 
Če prejemate odmerke večje od 75 mg na dan, bodo morda potrebni pogostejši zdravniški pregledi.
Consider to monitor TCA plasma levels, whenever a TCA is to be co-administered with another drug known to be an inhibitor of CYP2D6. 
Razmislite o spremljanju ravni TCA v plazmi, ko se TCA dajejo sočasno z drugim zdravilom, za katerega je znano,
Pharmacotherapeutic group 
Farmakoterapevtska skupina
Longer half-lives and decreased oral (Clo) clearance values due to a reduced rate of metabolism have been demonstrated in elderly patients. 
Pri starejših bolnikih so bile razpolovne dobe daljše, vrednosti peroralnega (Clo) očistka pa zmanjšane zaradi zmanjšane hitrosti presnove.
Amitriptyline hydrochloride 
amitriptilinijev klorid
Initially 25 mg 2 times daily (50 mg daily). 
Začetni odmerek je 25 mg dvakrat na dan (50 mg na dan).
• cisapride (used to treat certain types of indigestion) 
• cisaprid (uporablja se za zdravljenje prebavnih težav)
The excretion proceeds mainly with urine. 
Izločanje poteka pretežno s sečem.
If you receive doses in the range of 100 mg - 150 mg in the evening, your doctor may need to do more frequent follow-up with you. 
Če prejemate odmerke od 100 mg - 150 mg zvečer, bodo morda potrebni pogostejši zdravniški pregledi.
What you need to know before you are given Saroten solution for injection How you will be given X 
Kaj je zdravilo X in za kaj ga uporabljamo Kaj morate vedeti, preden vam bodo dali zdravilo Saroten raztopina za injiciranje Kako boste prejeli zdravilo X
Depending on your response to the medicine, your doctor may gradually increase the dose to 150 mg in the evening. 
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča do 150 mg zvečer.
• acute increase of pressure in the eye 
• akutno zvišanje očesnega tlaka
Elderly patients Longer half-lives values due to a reduced rate of metabolism have been demonstrated in elderly patients. 
Starejši bolniki Pri starejših bolnikih so bile razpolovne dobe daljše zaradi zmanjšane hitrosti presnove.
<[Saroten and associated names prolonged-release capsules, hard ] Film-coated tablets 
<[Saroten in povezana imena trde kapsule s podaljšanim sproščanjem] Filmsko obložene tablete
<[Saroten and associated names 75 mg, modified release tablets] Amitriptyline hydrochloride> 
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem] amitriptilinijev klorid>
• Neuropathic pain in adults 
• nevropatske bolečine pri odraslih
For amitriptyline only limited clinical data are available regarding exposed pregnancies. 
Na voljo je malo kliničnih podatkov o izpostavljenosti amitriptilinu med nosečnostjo.
• increased pressure in the eye ball 
• zvišan tlak v zrklu
<[Saroten and associated names prolonged-release capsules, hard] X contains sucrose 
<[Saroten in povezana imena trde kapsule s podaljšanim sproščanjem] Zdravilo X vsebuje saharozo
Arrhythmia. 
hipokaliemija.
Take the container of this medicine with you if you go to a doctor or hospital. 
K zdravniku ali v bolnišnico vzemite tudi škatlo tega zdravila.
6.3 Shelf life [To be completed nationally] 6.4 Special precautions for storage [To be completed nationally] 6.5 Nature and contents of container [To be completed nationally] 6.6 Special precautions for disposal No special requirements for disposal. 
6.6 Posebni varnostni ukrepi za odstranjevanje Ni posebnih zahtev za odstranjevanje.
Pharmacotherapeutic group: Antidepressants - Non-selective monoamine reuptake inhibitor (tricyclic antidepressant) 
Antidepresivi - neselektivni zaviralci privzema monoaminov (triciklični antidepresivi)
What you need to know before you take X 3. 
Kaj morate vedeti, preden boste vzeli zdravilo X Ne jemljite zdravila X:
• difficulties passing urine 
• težave z uriniranjem
Cardiac arrhythmias and severe hypotension are likely to occur with high dosage. 
Pri velikih odmerkih se lahko pojavijo srčne aritmije in huda hipotenzija.
Depending on the response to the medicine, your doctor may gradually increase the dose to 150 mg per day divided in two doses. 
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča do 150 mg na dan, razdeljeno na dva odmerka.
The mean systemic clearance (Cls) is 39.24±10.18 L/h, range 24.53-53.73 L/h. 
Povprečni sistemski očistek (Cls) je 39,24 ± 10,18 l/h, razpon 24,53 - 53,73 l/h.
X can be added to an infusion or injected into a big muscle. 
Zdravilo X se lahko doda infuziji ali injicira v veliko mišico (i.m.
• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. 
• zdravljenje nočne enureze pri otrocih, starih 6 let in več, ko je bila organska patologija, vključno s spino bifido in podobnimi stanji, izključena in ki se niso odzvali na zdravljenje z zdravili, vključno s spazmolitiki in vazopresinu sorodnimi zdravili, ali druga zdravljenja brez zdravil.
If you receive doses in the range of 100 mg - 150 mg, your doctor may need to do more frequent follow-up with you. 
Če prejemate odmerke od 100 mg - 150 mg, bodo morda potrebni pogostejši zdravniški pregledi.
Intravenous infusion 
Intravensko infundiranje
Film-coated tablets <[Saroten and associated names 10 mg film-coated tablets, Saroten and associated names 25 mg filmcoated tablets] 
Filmsko obložene tablete <[Saroten in povezana imena 10 mg filmsko obložene tablete, Saroten in povezana imena 25 mg filmsko obložene tablete]
• heart muscle disease 
• obolenje srčne mišice
The appropriate formulation/strength should be selected for the starting doses and any subsequent dose increases. 
Za začetne odmerke in vsa nadaljnja zvečanja odmerkov je treba izbrati ustrezno obliko/jakost zdravila.
<[Saroten and associated names 50 mg film-coated tablets] Saroten and associated names 50 mg film-coated tablets are dividable tablets with three score lines. 
<[Saroten in povezana imena 50 mg filmsko obložene tablete] Zdravilo Saroten in povezana imena 50 mg filmsko obložene tablete so deljive tablete s tremi razdelilnimi zarezami.
In patients with the rare condition of shallow anterior chamber and narrow chamber angle, attacks of acute glaucoma due to dilation of the pupil may be provoked. 
Pri bolnikih z redko boleznijo plitvega sprednjega prekata očesa in ozkega zakotja lahko zaradi razširjenja zenic povzroči akutni glavkom.
Your doctor will give you Saroten solution for injection. 
Zdravilo Saroten raztopino za injiciranje vam bo dal zdravnik.
Other isozymes involved are CYP1A2 and CYP2C9. 
Druga dva izoencima, ki sodelujeta pri presnovi sta CYP1A2 in CYP2C9.
<[Saroten and associated names 75 mg, modified release tablets, Saroten and associated names 2 ml, 50 mg solution for injection] 
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem, Saroten in povezana imena 2 ml, 50 mg raztopina za injiciranje] amitriptilinijev klorid>
• sedatives (e.g. babiturates) 
• pomirjevala (npr. babiturati)
An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome. 
Nočna enureza Pred uvedbo zdravljenja z amitriptilinom je treba narediti EKG, da se izključi sindrom podaljšanega intervala QT.
Depending on your response to the medicine, your doctor may gradually increase the dose to a total daily dose of 100 mg divided in two doses. 
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča do skupnega dnevnega odmerka 100 mg, razdeljenega na dva odmerka.
• particular forms of abnormal heart rhythm (so called torsades de pointes) 
• določene oblike nenormalnega srčnega ritma (t.i. torsade de pointes) • alergijsko vnetje pljučnih mešičkov in pljučnega tkiva
The recommended daily dose is 25 mg - 75 mg. 
Priporočeni dnevni odmerek je 25 mg - 75 mg.
• An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome 
• Pred uvedbo zdravljenja z amitriptilinom je treba narediti EKG, da se izključi sindrom podaljšanega intervala QT.
Unless prescribed otherwise, adult patients receive 1 ampoule Saroten 2 ml (50 mg amitriptyline hydrochloride) in 250 to 500 ml sodium chloride solution 0.9% for 2-3 hours as a drip infusion under control of blood pressure and ECG. 
Če ni predpisano drugače, prejme odrasel bolnik 1 ampulo zdravila Saroten 2 ml (50 mg amitriptilinijevega klorida) v 250 do 500 ml 0,9 % raztopine natrijevega klorida v obliki 2 do 3urne kapalne infuzije.
Saroten and associated names (see Annex I) 25 mg prolonged-release capsules, hard Amitriptyline Saroten and associated names (see Annex I) 50 mg prolonged-release capsules, hard Amitriptyline Saroten and associated names (see Annex I) 75 mg modified-release tablet Amitriptyline hydrochloride 
Saroten in povezana imena (glejte Prilogo I) 25 mg trde kapsule s podaljšanim sproščanjem amitriptilin Saroten in povezana imena (glejte Prilogo I) 50 mg trde kapsule s podaljšanim sproščanjem amitriptilin Saroten in povezana imena (glejte Prilogo I) 75 mg tablete s prirejenim sproščanjem amitriptilinijev klorid
• swelling of the salivary glands 
• otekle žleze slinavke
Those parts currently not needed can be stored in the reservoir of the tablet box (under the slide of the closure), until the next administration.> 
Deli, ki trenutno niso potrebni, se lahko do naslednjega dajanja shranijo v predalčku škatle za tablete (pod drsnim delom zaporke).>
• Bed-wetting at night in children aged 6 years and above, only when organic causes, such as spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including muscle relaxants and desmopressin. 
• nočnega močenja postelje pri otrocih, starih 6 let in več, pri katerih so bili organski vzroki, kot sta spina bifida in podobna stanja, izključeni in ki se niso odzvali na zdravljenje z zdravili, tudi z mišičnimi relaksanti in dezmopresinom, in druga zdravljenja brez zdravil.
• blue discolouration of the skin 
• pomodrelost kože
Clinically relevant interactions may be expected with concomitant use of amitriptyline and strong CYP3A4 inhibitors such as ketoconazole, itraconazole and ritonavir. 
Pri sočasni uporabi amitriptilina in močnih zaviralcev CYP3A4, kot so ketokonazol, itrakonazol in ritonavir, so možne klinično pomembne interakcije.
Package leaflet: Information for the patient Saroten and associated names 2 ml, 50 mg solution for injection Amitriptyline hydrochloride 
Navodilo za uporabo Saroten in povezana imena 2 ml, 50 mg raztopina za injiciranje amitriptilinijev klorid
Unless prescribed otherwise adults will receive their daily dosages in 250 to 500 ml sodium chloride solution 0.9% for 2-3 hours as a drip infusion under control of blood pressure and ECG. 
Če ni predpisano drugače, prejmejo odrasli dnevne odmerke v 250 do 500 ml 0,9 % raztopine natrijevega klorida v obliki 2 do 3-urne kapalne infuzije.