natgillin/translations-raw huggingface dataset:
The main measure of effectiveness was based on improvements in patients' forced expiratory volumes (FEV1, the maximum volume of air a person can breathe out in one second).
Glavno merilo za učinkovitost je temeljilo na izboljšanju forsiranega ekspiracijskega volumna (FEV1 - največja prostornina zraka, ki ga lahko bolnik izdihne v eni sekundi).
In the second study, the main measure of effectiveness was how the patients rated their respiratory symptoms on a standard scale for cystic fibrosis.
V drugi študiji je bilo glavno merilo učinkovitosti, kako so bolniki ocenili svoje dihalne simptome na standardni lestvici za cistično fibrozo.
A third main study involving 268 patients (including 59 children from six to 17 years of age) compared Cayston with another inhaled antibiotic (tobramycin nebuliser solution).
Tretja glavna študija, ki je vključevala 268 bolnikov (vključno z 59 otroki, starimi od šest do 17 let), je primerjala zdravilo Cayston z drugim inhalacijskim antibiotikom (inhalacijska raztopino za nebulator s tobramicinom).
In patients with cystic fibrosis, P. aeruginosa infections usually start in the first 10 years of life and can cause long-term lung problems.
Pri bolnikih s cistično fibrozo se okužbe z bakterijo P. aeruginosa običajno začnejo v prvih desetih letih življenja in lahko povzročajo dolgotrajne težave v pljučih.
This leads to problems with the digestion and absorption of food, resulting in poor growth, and long-term infection and inflammation of the lungs because of excess mucus not being cleared away.
To povzroči težave s prebavo in absorpcijo hrane, kar privede do upočasnjene rasti, ter dolgotrajno okužbo in vnetje pljuč zaradi kopičenja čezmerne sluzi.
It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Cayston.
Pojasnjuje, kako je Odbor za zdravila za uporabo v humani medicini (CHMP) ocenil zdravilo Cayston, na podlagi česar je oblikoval mnenje za odobritev dovoljenja za promet z njim in priporočila glede pogojev njegove uporabe.
Cayston must not be used in people who are hypersensitive (allergic) to aztreonam or any of the other ingredients.
Zdravila Cayston ne smejo uporabljati osebe, ki utegnejo biti preobčutljive za (alergične na) aztreonam ali katero koli drugo sestavino zdravila.
The full EPAR for Cayston can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Cayston je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Because the number of patients with bacterial lung infection in cystic fibrosis is low, the disease is considered ‘rare', and Cayston was designated an ‘orphan medicine' (a medicine used in rare diseases) on 21 June 2004.
Ker je bolnikov s cistično fibrozo, ki imajo bakterijsko pljučno okužbo, malo, velja bolezen za redko, zato je bilo zdravilo Cayston 21. junija 2004 določeno kot „zdravilo sirota“ (zdravilo, ki se uporablja pri redkih boleznih).
In the first study, the main measure of effectiveness was how long it took before the patients needed other antibiotics by inhalation or injection into a vein.
Glavno merilo učinkovitosti v prvi študiji je bil čas, preden je bolnik potreboval druge inhalacijske ali intravenozne antibiotike.
If the doctor thinks that further treatment cycles with Cayston are needed after the first course, a gap of four weeks is recommended after every four-week treatment cycle with Cayston.
Če zdravnik meni, da so po prvem ciklu zdravljenja z zdravilom Cayston potrebni nadaljnji cikli zdravljenja, je priporočen štiritedenski premor po vsakem štiritedenskem ciklu z zdravilom Cayston.
It contains the active substance aztreonam.
Vsebuje zdravilno učinkovino aztreonam.
For the full list of all side effects reported with Cayston, see the package leaflet.
Za celoten seznam vseh neželenih učinkov, o katerih so poročali pri uporabi zdravila Cayston, glejte navodilo za uporabo.
What is the risk associated with Cayston?
Kakšna tveganja so povezana z zdravilom Cayston?
In the first study, the patients who received Cayston required other antibiotics after 92 days, compared with 71 days for the patients who received placebo.
V eni študiji so bolniki, ki so prejemali zdravilo Cayston, druge antibiotike potrebovali po 92 dneh, bolniki, ki so prejemali placebo pa po 71 dneh.
The most common side effects with Cayston (seen in more than 1 patient in 10) are wheezing, cough, pharyngolaryngeal pain (pain in the throat and voice box), nasal congestion (blocked nose), dyspnoea (difficulty breathing) and fever.
Najpogostejši neželeni učinki zdravila Cayston (opaženi pri več kot 1 bolniku od 10) so sopenje, kašelj, faringolaringalna bolečina (bolečina v grlu in govornem aparatu), zamašen nos in povišana telesna temperatura.
It looked at how well the lungs worked, the amount of P. aeruginosa bacteria in the patients' mucus and their respiratory symptoms.
Proučevali so, kako dobro pljuča delujejo, količino bakterije P. aeruginosa v bolnikovi sluzi in dihalne simptome.
Cayston is to be used with a nebuliser (a special machine that changes the solution into an aerosol that the patient can breathe in).
Zdravilo Cayston se mora uporabljati s pomočjo nebulatorja (posebne priprave, ki raztopino spremeni v aerosol, ki ga lahko bolnik vdihava).
Why has Cayston been approved?
Zakaj je bilo zdravilo Cayston odobreno?
In the second study, respiratory symptoms improved in the patients who received Cayston, compared with the patients who received placebo.
Druga študija je pokazala, da so se dihalni simptomi izboljšali pri bolnikih, ki so prejemali zdravilo Cayston, v primerjavi s tistimi, ki so prejemali placebo.
If the patient takes multiple inhaled treatments the bronchodilator should always be taken first, followed by a mucolytic (a medicine to make mucus thinner) and Cayston last.
Če bolnik prejema več inhalacijskih oblik zdravljenja, je treba najprej vedno uporabiti bronhodilatator, čemur sledi mukolitik (zdravilo za redčenje sluzi) in nazadnje zdravilo Cayston.
Cayston was compared with placebo (a dummy treatment) in two main studies involving a total of 375 patients with cystic fibrosis who had long-term lung infection due to P.aeruginosa, most of whom were adults.
Zdravilo Cayston so primerjali s placebom (zdravilom brez zdravilne učinkovine) v dveh glavnih študijah, v kateri je bilo skupaj vključeno 375 bolnikov s cistično fibrozo, ki so imeli dolgotrajno pljučno okužbo s P. aeruginosa in od katerih je bila večina odraslih.
The CHMP concluded that there was an unmet medical need for new antibiotics in patients with cystic fibrosis, since many of these patients have already developed resistance to other antibiotics by the time they reach adulthood, and because P. aeruginosa lung infections are a cause of severe health problems in patients with cystic fibrosis.
Odbor za zdravila za uporabo v humani medicini (CHMP) je ugotovil, da je obstajala potreba po novem antibiotiku za zdravljenje bolnikov s cistično fibrozo, saj številni bolniki do odrasle dobe že razvijejo odpornost na druge antibiotike, pljučne okužbe, ki jih povzroča bakterija P. aeruginosa, pa so vzrok za hude zdravstvene težave pri bolnikih s cistično fibrozo.
Cystic fibrosis is an inherited disease that affects the cells that secret mucus in the lungs and the cells that secret digestive juices from the glands in the gut and pancreas.
Cistična fibroza je dedna bolezen, ki prizadene celice v pljučih, ki izločajo sluz, in celice, ki izločajo prebavne sokove iz žlez v črevesju ter trebušni slinavki.
In cystic fibrosis, the patient's lungs produce too much thick mucus, which allows bacteria to grow more easily.
Pri cistični fibrozi v bolnikovih pljučih nastaja preveč goste sluzi, ki bakterijam omogoča lažjo rast.
The third study showed that Cayston compared favourably with the comparator antibiotic: after four weeks of treatment, the increase in FEV1 adjusted for age, height and sex was 8.35% with Cayston and 0.55% with the comparator; after three treatment cycles, the increase with Cayston was 2.05% compared with a decrease of 0.66% with the comparator.
Tretja študija je pokazala, da je bilo zdravilo Cayston boljše kot primerjalni antibiotik: po štirih tednih zdravljenja je bilo povečanje FEV1, prilagojeno glede na starost, telesno višino in spol, 8,35 % pri zdravilu Cayston in 0,55 % pri primerjalnem zdravilu.
Cayston is used to suppress long-term lung infection caused by P. aeruginosa bacteria in adults and children aged six years or older with cystic fibrosis.
Zdravilo Cayston se uporablja za zaviranje dolgotrajne pljučne okužbe, ki jo povzroči bakterija P. Aeruginosa pri odraslih bolnikih in otrocih (starih 6 let ali več) s cistično fibrozo.
An improvement in lung function was also seen in children aged six to 17 years, both after four weeks of treatment and after three treatment cycles.
Izboljšanje pljučnega delovanja so po štirih tednih in treh ciklih zdravljenja opazili tudi pri otrocih, starih od šest do 17 let.
The active substance in Cayston, aztreonam, is an antibiotic that belongs to the group ‘beta-lactams'.
Zdravilna učinkovina v zdravilu Cayston, aztreonam, je antibiotik, ki spada v skupino betalaktamov.
In Cayston, aztreonam is available as a ‘lysine salt', which makes it possible for the antibiotic to be breathed directly into the lungs without causing irritation.
Aztreonam je od osemdesetih let prejšnjega stoletja na voljo v obliki injekcije kot „argininska sol“ V zdravilu Cayston je aztreonam na voljo kot „lizinska sol“, ki omogoča, da se antibiotik vdihne neposredno v pljuča, ne da bi to povzročilo draženja.
Cayston is a powder and solvent that are made up into a nebuliser solution.
Zdravilo Cayston je prašek in vehikel za pripravo raztopine za nebulator.
In cystic fibrosis these secretions become thick, blocking the airways and the flow of digestive juices.
Pri cistični fibrozi ti izločki postanejo zgoščeni, kar zapira dihala in pretok prebavnih sokov.
An additional study compared four weeks of Cayston with placebo in patients with mild lung disease due to cystic fibrosis.
V dodatni študiji so primerjali štiritedensko dajanje zdravila Cayston s placebom pri bolnikih z zmernim pljučnim obolenjem, ki je posledica cistične fibroze.
How has Cayston been studied?
Kako je bilo zdravilo Cayston raziskano?
How does Cayston work?
Kako zdravilo Cayston deluje?
What is Cayston used for?
Za kaj se zdravilo Cayston uporablja?
What is Cayston?
Kaj je zdravilo Cayston?
Cayston was more effective than placebo at suppressing lung infection caused by P. aeruginosa bacteria in patients with cystic fibrosis.
Zdravilo Cayston je bilo pri zaviranju kronične pljučne okužbe, ki jo povzroči bakterija P. aeruginosa, pri odraslih bolnikih s cistično fibrozo učinkovitejše od placeba.
A bronchodilator (a medicine that widens the airways in the lungs) should be used before each dose of Cayston.
Pred vsakim odmerkom zdravila Cayston je treba vzeti bronhodilator (zdravilo, ki širi dihalne poti v pljučih).
How is Cayston used?
Kako se zdravilo Cayston uporablja?
It works by attaching to proteins on the surface of the P. aeruginosa bacteria.
Deluje tako, da se veže na beljakovine na površini bakterije P. aeruginosa, kar bakteriji onemogoči gradnjo celičnih sten zaradi česar odmrejo.
Date of first authorisation: 4 January 2007 Date of latest renewal: 21 November 2011
Datum prve odobritve: 4. januar 2007 Datum zadnjega podaljšanja: 21. november 2011
It contains important information reminding you how to take ADROVANCE properly.
Ta vsebuje pomembne informacije, ki vas spomnijo, kako pravilno jemati zdravilo ADROVANCE.
Therefore, caution should be used when these medicines are taken at the same time as ADROVANCE.
Zato je potrebna previdnost, kadar ta zdravila uporabljate istočasno kot zdravilo ADROVANCE.
Children and adolescents ADROVANCE should not be given to children and adolescents less than 18 years of age.
Otroci in mladostniki Zdravila ADROVANCE se ne sme dajati otrokom in mladostnikom, mlajšim od 18 let.
Since it is not known how long you should take ADROVANCE, you should discuss the need to stay on this medicine with your doctor periodically to determine if ADROVANCE is still right for you.
Ker ni znano, kako dolgo je treba jemati zdravilo ADROVANCE, se morate glede nadaljevanja zdravljenja s tem zdravilom redno posvetovati z zdravnikom, ki bo odločil, ali je zdravljenje z zdravilom ADROVANCE za vas še vedno primerno.
ADROVANCE has no or negligible direct influence on the ability to drive and use machines.
Zdravilo ADROVANCE nima neposrednega vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
The need for continued treatment should be re-evaluated periodically based on the benefits and potential risks of ADROVANCE on an individual patient basis, particularly after 5 or more years of use.
Potrebo po nadaljevanju zdravljenja z zdravilom ADROVANCE je treba ponovno periodično oceniti glede na koristi in tveganja za posameznega bolnika, še posebno po 5 letih ali več uporabe.
If you take more ADROVANCE than you should If you take too many tablets by mistake, drink a full glass of milk and contact your doctor immediately.
Če ste vzeli večji odmerek zdravila ADROVANCE, kot bi smeli Če po pomoti vzamete preveč tablet, popijte poln kozarec mleka in nemudoma pokličite zdravnika.
Due to the nature of the disease process in osteoporosis, ADROVANCE is intended for long-term use.
Zaradi narave bolezenskega procesa osteoporoze je zdravilo ADROVANCE namenjeno za dolgotrajno uporabo.
The safety and efficacy of ADROVANCE in children less than 18 years of age have not been established.
Varnost in učinkovitost zdravila ADROVANCE pri otrocih, mlajših od 18 let, nista bili dokazani.
• Patients should not lie down for at least 30 minutes after taking ADROVANCE and until after the first food of the day.
• Bolnik se ne sme uleči še vsaj 30 minut po zaužitju tablete ADROVANCE in dokler ne zaužije prvega dnevnega obroka hrane.
It is important to maintain good oral hygiene when being treated with ADROVANCE.
Pomembno je, da med zdravljenjem z zdravilom ADROVANCE vzdržujete dobro ustno higieno.
What ADROVANCE is and what it is used for What you need to know before you take ADROVANCE How to take ADROVANCE Possible side effects
Kaj je zdravilo ADROVANCE in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo ADROVANCE Kako jemati zdravilo ADROVANCE Možni neželeni učinki
ADROVANCE is only intended for use in postmenopausal women and therefore it should not be used during pregnancy or in breast-feeding women.
Zdravilo ADROVANCE je namenjeno le ženskam po menopavzi, zato se ga ne sme uporabljati v času nosečnosti ali dojenja.
Hypocalcaemia must be corrected before initiating therapy with ADROVANCE (see section 4.3).
Hipokalciemijo je treba korigirati pred začetkom zdravljenja z zdravilom ADROVANCE (glejte poglavje 4.3).
What you need to know before you take ADROVANCE
Kaj morate vedeti preden boste vzeli zdravilo ADROVANCE
As well as your treatment with ADROVANCE, your doctor may suggest you make changes to your lifestyle to help your condition, such as:
Poleg zdravljenja z zdravilom ADROVANCE vam zdravnik lahko svetuje nekaj sprememb v načinu življenja, ki pomagajo pri vaši bolezni.
ADROVANCE should not be used during pregnancy.
Zdravila ADROVANCE se med nosečnostjo ne sme uporabljati.
• ADROVANCE should only be swallowed after getting up for the day with a full glass of water (not less than 200 ml).
• Bolnik mora zdravilo ADROVANCE pogoltniti zjutraj, ko vstane, s polnim kozarcem vode (ne manj kot 200 ml).
An Instruction Card is included in the carton for ADROVANCE.
V škatli zdravila ADROVANCE je priložena kartica z navodili.
• Patients should only swallow ADROVANCE whole.
• Bolnik mora pogoltniti celo tableto ADROVANCE.
4) Do not take ADROVANCE at bedtime or before getting up for the day.
4) Zdravila ADROVANCE ne jemljite zvečer ali preden zjutraj vstanete.
Remember, take ADROVANCE once each week on that same day for as long as your doctor prescribes it.
Zapomnite si - zdravilo ADROVANCE je treba vzeti le enkrat na teden, vedno na isti dan v tednu, tako dolgo, kot vam ga je predpisal zdravnik.
Other medicines and ADROVANCE
Druga zdravila in zdravilo ADROVANCE
5) If you develop difficulty or pain upon swallowing, chest pain, or new or worsening heartburn, stop taking ADROVANCE and contact your doctor.
5) Če se pojavijo težave ali bolečine pri požiranju, bolečine v prsih, zgaga ali če se težave z zgago stopnjujejo, prenehajte jemati zdravilo ADROVANCE in se posvetujte z zdravnikom.
When you get out of bed on the day you have chosen, and before taking your first food, drink or other medicines, swallow (do not crush or chew the tablet or allow it to dissolve in your mouth) one ADROVANCE tablet with a full glass of water (not mineral water).
Ko na izbrani dan zjutraj vstanete in še preden pojeste prvo hrano ali popijete prvo pijačo ali vzamete katero koli drugo zdravilo, pogoltnite (ne zdrobite, ne žvečite in ne raztapljajte v ustih) eno tableto ADROVANCE s polnim kozarcem vode (ne z mineralno vodo).
It is likely that calcium supplements, antacids, and some oral medicines will interfere with the absorption of ADROVANCE if taken at the same time.
Dodatki kalcija, antacidi in nekatera zdravila, ki jih zaužijete, lahko motijo absorpcijo zdravila ADROVANCE, če jih vzamete istočasno.
Patients should be instructed that if they miss a dose of ADROVANCE they should take one tablet on the morning after they remember.
Bolnikom je treba naročiti, naj v primeru, da pozabijo vzeti odmerek zdravila ADROVANCE, vzamejo eno tableto zjutraj potem, ko se spomnijo.
ADROVANCE must be taken with water only (not mineral water) at least 30 minutes before the first food, beverage, or medicinal product (including antacids, calcium supplements and vitamins) of the day.
Zdravilo ADROVANCE je treba vzeti izključno z navadno vodo (ne z mineralno vodo) najmanj 30 minut pred prvim dnevnim obrokom hrane in pijače ali zaužitjem drugih zdravil (vključno z antacidi, pripravki kalcija in vitamini).
Take one ADROVANCE tablet once a week.
Vzemite eno tableto ADROVANCE enkrat na teden.
6) After swallowing your ADROVANCE tablet, wait at least 30 minutes before taking your first food, drink, or other medicine of the day, including antacids, calcium supplements and vitamins.
6) Ko pogoltnete tableto ADROVANCE, vsaj še 30 minut počakajte, preden zaužijete prvo hrano, pijačo ali katero koli drugo zdravilo, vključno z antacidi, dodatki kalcija in vitamini.
5 How to store ADROVANCE Contents of the pack and other information
Shranjevanje zdravila ADROVANCE Vsebina pakiranja in dodatne informacije
• if you are allergic to alendronic acid, colecalciferol or any of the other ingredients of this medicine (listed in section 6),
• če ste alergični na alendronsko kislino, holekalciferol ali katero koli sestavino tega zdravila
You may be advised to have a dental check-up before starting treatment with ADROVANCE.
Zdravnik vam bo lahko pred začetkom zdravljenja z zdravilom ADROVANCE svetoval zobozdravniški pregled.
Patients may experience certain adverse reactions (for example blurred vision, dizziness and severe bone muscle or joint pain (see section 4.8)) that may influence the ability to drive and use machines.
Pri bolnikih se lahko pojavijo določeni neželeni učinki (npr. zamegljen vid, omotica in hude bolečine v kosteh, mišicah ali sklepih (glejte poglavje 4.8)), ki lahko vplivajo na sposobnost vožnje in upravljanja strojev.
Do not take ADROVANCE
Ne jemljite zdravila ADROVANCE
If you forget to take ADROVANCE
Če ste pozabili vzeti zdravilo ADROVANCE
What ADROVANCE looks like and contents of the pack
Izgled zdravila ADROVANCE in vsebina pakiranja
What ADROVANCE is and what it is used for
Kaj je zdravilo ADROVANCE in za kaj ga uporabljamo
If you miss a dose, take only one ADROVANCE tablet on the morning after you remember.
Če pozabite vzeti odmerek, vzemite le eno tableto ADROVANCE naslednje jutro, potem ko se spomnite.
Irritation, inflammation or ulceration of the gullet (oesophagus - the tube that connects your mouth with your stomach) often with symptoms of chest pain, heartburn, or difficulty or pain upon swallowing may occur, especially if patients do not drink a full glass of water and/or if they lie down less than 30 minutes after taking ADROVANCE.
Po zaužitju lahko pride do draženja, vnetja ali razjede požiralnika, pogosto z bolečino v prsnem košu, zgago ali oteženim ali bolečim požiranjem, še posebej, če bolnik ne spije polnega kozarca vode in/ali če se uleže prej kot v 30 minutah po zaužitju zdravila ADROVANCE.
What is ADROVANCE used for?
Za kaj uporabljamo zdravilo ADROVANCE?
The mean half-life of vitamin D3 in the serum following an oral dose of ADROVANCE (70 mg/2,800 IU) is approximately 24 hours.
Povprečni razpolovni čas vitamina D3 v serumu po peroralnem odmerku zdravila ADROVANCE (70 mg/2.800 i.e.) je približno 24 ur.
ADROVANCE is effective only if taken when your stomach is empty.
Zdravilo ADROVANCE je učinkovito samo, če ga vzamete na tešče.
ADROVANCE is not recommended for patients with renal impairment where creatinine clearance is less than 35 ml/min, due to lack of experience.
Bolnikom z okvaro ledvic, pri katerih je kreatininski očistek manjši od 35 ml/min, zdravila ADROVANCE zaradi pomanjkanja izkušenj ne priporočamo.
ADROVANCE is a tablet containing the two active substances, alendronic acid (commonly called alendronate) and colecalciferol known as vitamin D3.
ADROVANCE je tableta, ki vsebuje dve učinkovini: alendronsko kislino (splošno poimenovano alendronat) in holekalciferol oziroma vitamin D3.
ADROVANCE should not be used during breast-feeding.
Zdravila ADROVANCE se med dojenjem ne sme uporabljati.
ADROVANCE is only intended for use in postmenopausal women.
Zdravilo ADROVANCE je namenjeno le ženskam po menopavzi.
How to take ADROVANCE tablets
Kako jemati tablete ADROVANCE
ADROVANCE is not recommended for patients with renal impairment where creatinine clearance is less than 35 ml/min (see section 4.2).
Bolnikom, pri katerih je kreatininski očistek manjši od 35 ml/min, zdravila ADROVANCE ne priporočamo (glejte poglavje 4.2).
Patients received the lower strength (70 mg/2,800 IU) of ADROVANCE (n=350) or FOSAMAX (alendronate) 70 mg (n=332) once a week; additional vitamin D supplements were prohibited.
Bolnice so enkrat tedensko dobivale manjšo jakost (70 mg/2.800 i.e.) zdravila ADROVANCE (n = 350) ali zdravilo FOSAMAX (alendronat) 70 mg (n = 332); jemanje dodatkov vitamina D je bilo prepovedano.
ADROVANCE studies
Študije z zdravilom ADROVANCE
The bioavailability of the 5,600 IU vitamin D3 in ADROVANCE is similar to 5,600 IU vitamin D3 administered alone.
Biološka uporabnost 5.600 i.e. vitamina D3 v zdravilu ADROVANCE je podobna kot pri zaužitju 5.600 i.e. vitamina D3 samega.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Zdravilo ADROVANCE vsebuje laktozo in saharozo Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred jemanjem tega zdravila pogovorite z zdravnikom.
The effect of the lower dose of ADROVANCE (alendronate 70 mg/vitamin D3 2,800 IU) plus an additional 2,800 IU Vitamin D3 for a total of 5,600 IU (the amount of vitamin D3 in the higher dose of ADROVANCE) once weekly was demonstrated in a 24-week, extension study that enrolled 619 osteoporotic post-menopausal women.
Vpliv manjšega odmerka zdravila ADROVANCE (alendronat 70 mg/vitamin D3 2.800 i.e.) in dodatnih 2.800 i.e. vitamina D3, kar pomeni skupaj 5.600 i.e. (količina vitamina D3 v večjem odmerku zdravila ADROVANCE), enkrat tedensko, so ugotavljali v 24-tedenski podaljšani študiji, v katero je bilo vključenih 619 žensk s pomenopavzalno osteoporozo.
The bioavailability of the 2,800 IU vitamin D3 in ADROVANCE is similar to 2,800 IU vitamin D3 administered alone.
Biološka uporabnost 2.800 i.e. vitamina D3 v zdravilu ADROVANCE je podobna kot pri zaužitju 2.800 i.e. vitamina D3 samega.