natgillin/translations-raw huggingface dataset:
The CVMP concluded that the benefits of Zolvix exceed the risks for the approved indications and recommended that Zolvix be given a marketing authorisation.
CVMP je zaključil, da so koristi zdravila Zolvix večje od z njim povezanih tveganj, kadar se uporablja za odobrene indikacije, in priporočil, da se zanj odobri dovoljenje za promet.
Helminths, also known as nematodes, are worm-like parasites that live in the gut of animals.
Helminti, znani tudi kot gliste, so glistam podobni zajedavci, ki živijo v črevesju živali.
The studies showed that Zolvix is effective against infections of all of the major gastrointestinal nematodes, including effectiveness against strains of parasites resistant to the currently available broad-spectrum anthelmintics.
Študije so pokazale, da je zdravilo Zolvix učinkovito proti okužbam vseh pomembnejših želodčnočrevesnih glist, vključno s sevi zajedavcev, ki so odporni na trenutno razpoložljive širokospektralne antihelmintike.
Zolvix is a medicine that contains the active substance monepantel.
Zolvix je zdravilo, ki vsebuje zdravilno učinkovino monepantel.
What is the risk associated with Zolvix?
Kakšna tveganja so povezana z zdravilom Zolvix?
Zolvix is not authorised for use in lactating animals producing milk for human consumption.
Zdravilo Zolvix ni odobreno za uporabo pri živalih v laktaciji, katerih mleko je namenjeno prehrani ljudi.
Monepantel blocks part of a receptor, the nicotinic acetylcholine receptor, that is specific to the nematodes.
Monepantel zavira del receptorja, nikotinski acetilholinski receptor, ki je značilen za gliste.
Why has Zolvix been approved?
Zakaj je bilo zdravilo Zolvix odobreno?
In case of accidental spillage onto skin or into eyes, the area should be washed immediately with water.
Če pride do nenamernega razlitja po koži ali če zdravilo pride v stik z očmi, izpostavljene dele takoj izperite z vodo.
In case of accidental ingestion medical advice should be sought immediately and the package leaflet or the label shown to the doctor.
V primeru nenamernega zaužitja se takoj posvetujte z zdravnikom in mu pokažite navodilo za uporabo ali ovojnino.
Zolvix is effective against a wide range of worm species.
Zdravilo Zolvix je učinkovito proti številnim vrstam zajedavcev.
Monepantel is effective against nematodes resistant to other anthelmintics.
Monepantel je učinkovit pri glistah, ki so odporne na druge antihelmintike.
What is Zolvix used for?
Za kaj se zdravilo Zolvix uporablja?
How has Zolvix been studied?
Kako je bilo zdravilo Zolvix raziskano?
The New Zealand study and some additional studies compared the effectiveness of Zolvix to other anthelmintics.
V študiji na Novi Zelandiji in nekaterih dodatnih študijah so primerjali učinkovitost zdravila Zolvix z drugimi antihelmintiki Učinkovitost zdravila Zolvix so v študijah merili s prisotnostjo jajčec zajedavcev v ovčjih iztrebkih ob različnih trenutkih med preskusi.
How does Zolvix work?
Kako zdravilo Zolvix deluje?
The user must not eat, drink or smoke whilst handling the product and hands and exposed skin should be washed after handling the product.
Uporabnik med rokovanjem z zdravilom ne sme jesti, piti ali kaditi.
Monepantel, is an anthelmintic, a substance that is active against helminths.
Monepantel je antihelmintik, tj. snov, ki učinkuje proti helmintom.
What is Zolvix?
Kaj je zdravilo Zolvix?
CONCLUSIONS ON THE GRANTING OF THE CONDITIONAL MARKETING AUTHORISATION PRESENTED BY THE EUROPEAN MEDICINES AGENCY
PRILOGA IV SKLEPNE UGOTOVITVE O PRIDOBITVI POGOJNEGA DOVOLJENJA ZA PROMET Z ZDRAVILOM, KI JIH JE PREDSTAVILA EVROPSKA AGENCIJA ZA ZDRAVILA
ATC vet code: QP54AB52.
Oznaka ATC vet: QP54AB52.
The tablets should not be divided.
Tablet se ne sme deliti.
The use in these animals is not recommended.
Uporaba pri teh živalih ni priporočljiva.
If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth.
Če pes tablete ne vzame prostovoljno, mu jo lahko daste tudi s hrano ali direktno v gobec.
However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed.
Vendar je pri teh občutljivih pasmah (ki lahko vključujejo, toda niso nujno omejene na kolije in sorodne pasme) treba strogo upoštevati priporočeni odmerek.
Therefore, the use of this product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species in order to limit the possibility of a future selection for resistance.
Zato bi morala uporaba tega zdravila temeljiti na oceni vsakega posameznega primera in na lokalnih epidemioloških podatkih o trenutni občutljivosti ciljnih vrst, da se omeji možnost nadaljnje selekcije glede odpornosti.
Treatment schedule:
Shema zdravljenja:
Each tablet strength is available in pack sizes of 1, 3 or 6 tablets.
Tablete posamezne jakosti so na voljo v pakiranjih po 1, 3 ali 6 tablet.
Parasite resistance to any particular class of parasiticides may develop following the frequent, repeated use of a product of that class.
Odpornost parazitov na kateri koli razred antiparazitika se lahko razvije po pogosti, ponavljajoči se uporabi zdravila tistega razreda.
The treatment schedule should be based on veterinary diagnosis, the local epidemiological situation and/or the epidemiological situation of other areas the dog has visited or is going to visit.
Shema zdravljenja mora temeljiti na veterinarski diagnozi, lokalni epidemiološki situaciji oziroma epidemiološki situaciji na drugih območjih, ki jih je ali jih bo pes obiskal.
However, accidental administration to dogs infected with adult heartworms should not pose safety concerns.
Vendar nenamerno dajanje zdravila psom, okuženih z odraslimi srčnimi glistami, ne bi smelo predstavljati pomislekov glede varnosti.
Dogs in areas endemic for heartworm (or those which have travelled to endemic areas) may be infected with adult heartworms.
Psi na območjih, ki so endemična za srčne gliste (ali tisti, ki so potovali na endemična območja), so lahko okuženi z odraslimi srčnimi glistami.
For dogs with, or at risk from, mixed external and internal parasitic infestations.
Za pse, ki imajo oziroma so izpostavljeni tveganju mešanih zunanjih in notranjih parazitskih infestacij.
To prevent children from accessing the product, only one chewable tablet at a time should be removed from the blister pack and only when required.
Da bi preprečili otrokom dostop do zdravila, se mora iz pretisnega omota vzeti le ena žvečljiva tableta naenkrat in samo kadar je to potrebno.
Method of administration Tablets can be administered with or without food.
Način uporabe Tablete lahko dajemo s hrano ali brez nje.
This results in flaccid paralysis and eventual death of parasites exposed to the drug.
Posledica tega je flakcidna paraliza in posledično smrt parazitov izpostavljenih zdravilu.
Appropriate combination of tablets
Primerna kombinacija tablet
Ticks and fleas need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious parasite-borne diseases cannot be excluded.
Klopi in bolhe se morajo začeti hraniti na gostitelju, da so izpostavljeni sarolanerju, zato prenos infekcijskih bolezni, ki so prenosljive s paraziti, ni izključen.
Pyrantel embonate is poorly absorbed and the absorbed portion has a tmax of 1.5 hours and half-life of 7.7 hours.
Pirantelijev embonat se slabo absorbira in absorbirani del ima tmax 1,5 ure ter razpolovno dobo 7,7 ur.
Colorants: Sunset Yellow FCF (E110), Allura Red (E129), Indigo Carmine (E132).
Barvila: sončno rumeno FCF (E110), allura rdeče (E129), indigotin (E132).
Moxidectin is a second-generation macrocyclic lactone of the milbemycin family.
Moksidektin je makrociklični lakton druge generacije iz skupine milbemicina.
Date of first authorisation: 17/09/2019
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum pridobitve dovoljenja za promet: 17/09/2019
Pyrantel is eliminated through faeces and the small absorbed portion is eliminated mainly via urine.
Pirantel se izloča z blatom in majhen absorbirani del se v glavnem izloči z urinom.
Macrocyclic lactones including moxidectin have been shown to be substrates for p-glycoprotein.
Pokazalo se je, da so makrociklični laktoni, vključno z moksidektinom substrati za p-glikoprotein.
The prandial state of the dogs does not affect the extent of absorption of sarolaner and moxidectin.
Hranjenje psov ne vpliva na obseg absorpcije sarolanerja in moksidektina.
In this fixed combination, moxidectin and pyrantel provide complementary anthelmintic efficacy through distinct mechanisms of action.
V tej fiksni kombinaciji moksidektin in pirantel zagotavljata dodatno antihelmintično učinkovitost z drugačnimi mehanizmi delovanja.
Manufacturer responsible for batch release: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt 68723 Baden-Wuerttemberg GERMANY
Proizvajalec odgovoren za sproščanje serij: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt 68723 Baden-Wuerttemberg NEMČIJA
In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 1.25 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian.
Zaradi pomanjkanja podatkov, mora zdravljenje mladičev, mlajših od 8 tednov starosti oziroma psov, lažjih od 1,25 kg temeljiti na oceni razmerja korist/tveganje odgovornega veterinarja.
To minimise the risk of resistance selection, it is recommended that dogs should be checked for both circulating antigens and blood microfilariae at the beginning of each season of preventative treatment.
Za zmanjševanje tveganja za selekcijo glede odpornosti, se priporoča, da pse pred pričetkom vsakega obdobja preventivnega zdravljenja testira tako za antigene kot za mikrofilarije v krvnem obtoku.
Pyrantel is a nicotinic acetylcholine (ACh) channel receptor (nAChR) agonist.
Pirantel je nikotin acetilholinski (ACh) agonist kanalskega receptorja (nAChR).
In the absence of the risk of mixed co-infestation, a narrower spectrum parasiticide should be used.
Če ne obstaja tveganje za hkratno mešano infestacijo, je treba uporabiti ožji spekter antiparazitika.
EU/2/19/243/001-018
ŠTEVILKA(E) DOVOLJENJ(A) ZA PROMET EU/2/19/243/001-018
Maintenance of the efficacy of macrocyclic lactones is critical for Dirofilaria immitis control.
Vzdrževanje učinkovitosti makrocikličnih laktonov je ključnega pomena za nadzor okuženosti z Dirofilaria immitis.
pyrantel (as embonate) (mg)
pirantel (kot embonat) (mg)
It is recommended that heartworm prevention treatment should be continued until at least 1 month after the last exposure to mosquitoes.
Priporočljivo je, da se s preventivnim zdravljenjem srčnih glist nadaljuje vsaj 1 mesec po zadnji izpostavljenosti živali komarjem.
This veterinary medicinal product is not effective against adult D. immitis.
To zdravilo za uporabo v veterinarski medicini ne učinkuje na odraslo obliko D. immitis.
The accidental ingestion of the product may potentially result in adverse effects, such as transient excitatory neurological signs.
Nenamerno zaužitje zdravila lahko povzroči neželene učinke, kot so prehodni ekscitacijski nevrološki znaki.
In particular, both active substances contribute to the overall efficacy against the gastrointestinal nematodes Ancylostoma caninum and Toxocara canis.
Predvsem obe učinkovini prispevata k splošni učinkovitosti proti gastrointestinalnim nematodom Ancylostoma caninum in Toxocara canis.
When the product replaces another lungworm or heartworm preventive product, the first dose of the product should be given within a month of the last dose of the former veterinary medicinal product.
Kadar z zdravilom zamenjamo drugo preventivno zdravilo proti pljučni ali srčni glistavosti, moramo prvi odmerek zdravila dati v obdobju znotraj enega meseca po zadnjem dajanju prejšnjega zdravila za uporabo v veterinarski medicini.
The veterinary medicinal product kills newly emerged fleas on the dog before they can lay eggs and therefore it prevents environmental flea contamination in areas to which the dog has access.
To zdravilo za uporabo v veterinarski medicini ubije bolhe, ki pridejo na psa po dajanju zdravila, preden bi lahko izlegle jajčeca in tako prepreči onesnaženje okolja z bolhami na področjih, do katerih ima pes dostop.
Simparica Trio chewable tablets sarolaner (mg)
Simparica Trio žvečljive tablete sarolaner (mg)
Fleas on the animal prior to administration are killed within 8 hours.
Bolhe, ki so že na živali pred dajanjem zdravila so ubite v 8 urah.
− For the prevention of heartworm disease (Dirofilaria immitis);
− Za preprečevanje obolenja srčne glistavosti (Dirofilaria immitis);
− The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
− Zdravilo se lahko uporablja kot del strategije zdravljenja za nadzor alergijskega dermatitisa, ki ga povzročajo bolhe (flea allergy dermatitis - FAD).
After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient ataxia and/or muscle fasciculation were observed.
Po enkratnem dajanju 5-krat večjega odmerka od največjega priporočenega odmerka zdravila, so se pri teh občutljivih pasmah psov pojavili prehodna ataksija in/ali mišične fascikulacije.
The tablets are packaged in aluminium foil/foil blisters packaged into an outer carton box.
Tablete so pakirane v aluminijaste folija/folija pretisne omote pakirane v zunanjo kartonsko škatlo.
Therefore, during treatment with the veterinary medicinal product, other products that can inhibit pglycoprotein (e.g. cyclosporine, ketoconazole, spinosad, verapamil) should only be used concomitantly according to the benefit-risk assessment of the responsible veterinarian.
Zato je treba med zdravljenjem z zdravilom za uporabo v veterinarski medicini sočasno uporabljati druga zdravila, ki lahko zavirajo p-glikoprotein (npr. ciklosporin, ketokonazol, spinosad, verapamil) le v skladu z oceno razmerja korist/tveganje odgovornega veterinarja.
If based on veterinarian opinion re-administration(s) of the product is required, any subsequent administration(s) must follow the minimum 1-month interval schedule.
Če je na podlagi veterinarskega mnenja potrebna ponovna uporaba zdravila, mora vsaki naslednji uporabi slediti najmanj 1-mesečni razmik.
Pharmacotherapeutic group: antiparasitic products, moxidectin combinations.
Farmakoterapevtska skupina: antiparazitiki, moksidektin, kombinacije.
In endemic areas, dogs should receive lungworm and/or heartworm preventive treatments at monthly intervals.
Na endemičnih območjih morajo psi v mesečnih intervalih prejemati preventivna zdravljenja proti pljučni in/ali srčni glistavosti.
A single administration also prevents lungworm disease (by reducing the immature adults (L5) of A. vasorum) and heartworm disease (D. immitis) for one month.
Enkratni odmerek zdravila preprečuje tudi bolezen pljučne glistavosti (z zmanjševanjem nezrelih odraslih nematod (L5) A. vasorum) in bolezen srčne gliste (D. immitis) za en mesec.
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or label to the physician.
V primeru nenamernega zaužitja, se takoj posvetujete z zdravnikom in mu pokažite navodilo za uporabo ali ovojnino.
Only negative animals should be treated.
Zdraviti je treba le živali, ki so bile po testiranju negativne.
Following receptor binding, the channel opens to allow the influx of cations resulting in a depolarization and excitatory effects on nematode muscle, ultimately leading to spastic paralysis of the worm and death.
Po vezavi na receptorje se kanal odpre, da omogoči dotok kationov, kar povzroči depolarizacijo in ekscitatorne učinke na mišici nematodov, kar vodi do spastične paralize črva in smrti.
No adverse reactions were observed in 8-weeks old healthy puppies administered with up to 5 times the maximum recommended dose for 7 consecutive monthly administrations.
Nobenih neželenih učinkov niso opazili pri pasjih mladičih 8 tednov starih, zdravljenih z do 5-krat večjim odmerkom od največjega priporočenega odmerka, pri dajanju 7 mesecev zapored.
The veterinary medicinal product has immediate and persistent flea killing activity against new infestations for 5 weeks;
Zdravilo za uporabo v veterinarski medicini ima takojšen in trajen učinek ubijanja bolh nove infestacije vsaj 5 tednov;
For fleas, the onset of efficacy is within 12 to 24 hours of attachment for five weeks after product administration.
Pri bolhah začne zdravilo učinkovati v času od 12 do 24 ur po pritrditvi, v obdobju pet tednov po dajanju zdravila.
Ticks on the animal prior to administration or from new infestations after product administration are killed within 48 hours.
Klopi, ki so že na živali pred dajanjem zdravila ali po ponovni infestaciji po dajanju zdravila, so ubiti v 48 urah.
− For the prevention of angiostrongylosis by reducing the level of infection with immature adult
− Za preprečevanje angiostrongiloze z zmanjševanjem stopnje okužbe z nezrelimi odraslimi (L5)
In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistanceprotein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose.
V laboratorijski študiji so psi z nezadostnim MDR1 -/- (multidrug-resistance-protein 1) zdravilo po dajanju enkratnega peroralnega odmerka, ki je bil 3-krat večji od priporočenega odmerka zdravila dobro prenašali.
A single treatment is efficacious for the treatment of gastrointestinal nematodes.
Enkratno zdravljenje je učinkovito za zdravljenje okužb z gastrointestinalnimi nematodi.
Sarolaner does not interact with known insecticidal binding sites of nicotinic or other GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins, and cyclodienes.
Sarolaner ne deluje medsebojno z znanimi mesti vezave nikotinskih in drugih GABA-ergičnih insekticidov kot so neonikotinoidi, fiproli, milbemicini, avermektini in ciklodieni.
Do not use this veterinary medicinal product after the expiry date which is stated on the carton and blister after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na škatli in pretisnem omotu po {EXP}.
The veterinary medicinal product should be administered at a dose of 1.2-2.4 mg/kg of sarolaner, 0.024-0.048 mg/kg of moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table:
Zdravilo je treba dajati v odmerku 1,2 - 2,4 mg/kg sarolanerja, 0,024 - 0,048 mg/kg moksidektina in 5 - 10 mg/kg pirantela v skladu z naslednjo preglednico:
Sarolaner is active against adult fleas (Ctenocephalides felis and Ctenocephalides canis) as well as several tick species such as Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus.
Sarolaner deluje na odrasle bolhe (Ctenocephalides felis in Ctenocephalides canis) kot tudi na številne vrste klopov kot so Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus in Rhipicephalus sanguineus.
The blister pack should then be returned into the carton immediately after use and the carton should be stored out of the sight and reach of children.
Preostali pretisni omot je treba takoj po dajanju vrniti v škatlo, škatlo pa shranjevati nedosegljivo otrokom.
This interference leads to the opening of the chloride channels on the postsynaptic junction to allow the inflow of chloride ions.
Ta motnja vodi do odprtja kloridnih kanalov na postsinaptičnem stiku, kar poveča prepustnost za kloridne ione.
Prevention of heartworm disease and angiostrongylosis:
Preprečevanje bolezni srčne glistavosti in angiostrongiloze:
After treatment of the nematode infections, further flea and tick treatment should be continued with a mono-active product.
Po zdravljenju okužb z nematodi je treba nadaljevati zdravljenje okužb z bolhami in klopi z zdravilom z eno učinkovino.
Its principal mode of action is interfering with neuromuscular transmission at the level of the glutamate-gated chloride channels and, to a lesser extent, of GABA (gamma amino butyric acid)-gated channels.
Njegov glavni način delovanja je motenje živčno-mišičnega prenosa na ravni glutamat- odvisnih kloridnih kanalov in, v manjši meri, GABA (gama- aminomaslene kisline) odvisnih kanalov.
− For the treatment of flea infestations (Ctenocephalides felis and Ctenocephalides canis).
− Za zdravljenje infestacij z bolhami (Ctenocephalides felis in Ctenocephalides canis).
Each tablet contains:
KAKOVOSTNA IN KOLIČINSKA SESTAVA Vsaka tableta vsebuje:
Sarolaner is slowly eliminated from plasma (half-life of approximately 12 days) via biliary excretion and elimination through the faeces with minor contributions of metabolic clearance.
Sarolaner se počasi izloča iz plazme (razpolovna doba je približno 12 dni) z žolčem in blatom z manjšimi prispevki metaboličnega očistka.
The veterinary medicinal product can be used as part of the seasonal treatment of fleas and ticks (replacing treatment with a mono-active flea and tick product) in dogs with diagnosed concurrent gastrointestinal nematode infections.
Zdravilo za uporabo v veterinarski medicini se lahko uporablja pri sezonskem zdravljenju bolh in klopov (zamenjava zdravljenja z zdravilom z eno učinkovino proti bolham in klopom) pri psih, ki imajo hkrati diagnosticirano okužbo z gastrointestinalnimi nematodi.
Sarolaner is readily and rapidly absorbed systemically following oral dosing, reaching maximum concentrations in plasma within 3.5 hours (tmax) after administration with a high bioavailability of 86.7%.
Sarolaner se po peroralnem odmerjanju enostavno in hitro sistemsko absorbira in v 3,5 urah (tmax) po dajanju doseže največje koncentracije v plazmi z visoko biološko uporabnostjo 86,7 %.
The veterinary medicinal product also provides concurrent efficacy for the prevention of heartworm disease and angiostrongylosis.
Zdravilo za uporabo v veterinarski medicini je hkrati tudi učinkovito pri preprečevanju obolenja srčne glistavosti in angiostrongiloze.
Moxidectin is readily and rapidly absorbed systemically following oral dosing, reaching maximum concentrations in plasma within 2.4 hours (tmax) after administration and with 66.9% bioavailability.
Moksidektin se po peroralnem odmerjanju enostavno in hitro sistemsko absorbira in v 2,4 urah (tmax) po dajanju doseže največje koncentracije v plazmi z biološko uporabnostjo 66,9 %.
Pyrantel is active against immature stages (L5) and adults of Toxocara canis, adults of Ancylostoma caninum, Toxascaris leonina and Uncinaria stenocephala.
Pirantel je učinkovit proti nezrelim stopnjam (L5) in odraslim nematodom Toxocara canis, odraslim Ancylostoma caninum, Toxascaris leonina in Uncinaria stenocephala.
Pyrantel mimics the agonist effects of ACh through high affinity binding to subtype specific ionophoric nAChRs in nematodes, while not binding at muscarinic mAChRs.
Pirantel posnema agonistične učinke ACh z visoko afiniteto vezave na specifične podvrste ionofornih receptorjev nAChRs pri nematodih, vendar se ne veže na muskarinske receptorje mAChR.
The safety of the veterinary medicinal product has not been established during pregnancy and lactation or in dogs intended for breeding.
Varnost zdravila v obdobju brejosti in laktacije oziroma pri psih za vzrejo ni bila ugotovljena.
The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-).
Psi z nezadostnim MDR1 -/- (multidrug-resistance-protein 1) so zdravilo dobro prenašali.
Simparica Trio tablets are palatable and readily consumed by the majority of dogs when offered by the owner.
Tablete Simparica Trio so okusne zato jih psi radi sprejmejo od lastnika.
Sarolaner binding to these receptors prevents the uptake of chloride ions by GABA and glutamate gated ion channels, thus resulting in increased nerve stimulation and death of the target parasite.
Sarolaner, ki je vezan na te receptorje, preprečuje prehod kloridnih ionov preko GABA in glutamat odvisnih ionskih kanalov, kar se kaže v povečani živčni stimulaciji in smrti ciljnih parazitov.
The product should only be used in dogs when treatment of ticks / fleas and gastrointestinal nematodes is indicated at the same time.
Zdravilo se sme uporabljati samo pri psih, kadar je hkrati indicirano zdravljenje klopov/bolh in gastrointestinalnih nematodov.