Rare: - reduction in red blood cells (anaemia), increase in white blood cells (leucocytosis), alteration of the prothrombin (coagulation factor) values, reduction in blood platelets (thrombocytopenia) with bruises and tendency to bleed, increase in blood platelets (thrombocytosis) - swelling of the limbs and face (peripheral oedema, facial oedema), sudden swelling of the face or throat with difficulties in breathing and/or itching and rash, often as an allergic reaction (angioneurotic oedema), allergic reactions, fever due to the administration of the medicine, serious allergic reaction which causes difficulty in breathing or dizziness (anaphylactic reaction) - increased blood sugar level (hyperglycaemia) - anxieties, nightmares, severe depression, seeing things or hearing voices that do not exist (hallucinations) - reduced taste, altered sensation (paraesthesia), shaking (tremor), spasms/ convulsions (seizures), severe headache (migraine) - altered vision such as double vision (diplopia) and seeing all objects in a certain colour (chromatopsia) - ringing in the ear (tinnitus), transient hearing loss (particularly high frequencies) - increased heart rate (tachycardia) - fainting (syncope), widening of blood vessel (vasodilation) - shortness of breath (dyspnoea), swelling of the voice box (larynx) with difficulties in breathing (larynx oedema) - severe and continuous diarrhoea, possibly with blood and mucus, due to a severe inflammation of the large intestine (pseudo membranous colitis), fungal infection in the mouth (oral moniliasis) - yellowing of the skin or whites of the eyes (icterus), icterus due to a condition where the bile can not flow normally from the liver (cholestatic icterus), liver cell necrosis - increased sensitivity to light (photosensitivity), erythema multiforme and erythema nodusum - muscular pain (myalgia), joint disorder (swollen joints) - acute kidney failure, abnormal kidney function, vaginal secretion due to a fungal infection (vaginal moniliasis), blood in the urine (haematuria), presence of crystals in the urine with discomfort when passing urine (crystalluria), infection of the kidney with blood in the urine, fever and pain in the side (interstitial nephritis)
Redki: - zmanjšanje števila eritrocitov (anemija), povečanje števila levkocitov (levkocitoza), spremembe vrednosti protrombina (koagulacijskega faktorja), zmanjšanje števila trombocitov (trombocitopenija) s podplutbami in nagnjenostjo h krvavitvam, povečanje števila trombocitov (trombocitoza); - otekanje okončin in obraza (periferni edem, edem obraza), nenadno otekanje obraza ali grla s težavami pri dihanju in/ali srbenjem in izpuščajem, pogosto kot alergijska reakcija (angionevrotični edem), alergijske reakcije, zvišana telesna temperatura zaradi uporabe zdravila, resna alergijska reakcija, ki povzroča težave pri dihanju ali omotico (anafilaktična reakcija); - zvišan sladkor v krvi (hiperglikemija); - tesnoba, nočne more, huda depresija, videnje stvari ali slišanje glasov, ki ne obstajajo (halucinacije) - zmanjšan čut okusa, spremenjeno čutenje (parestezija), tresenje (tremor), krči/konvulzije (epileptični napadi), hud glavobol (migrena); - spremembe vida, kot je dvojni vid (diplopija) in videnje predmetov v določeni barvi (kromatopsija); - zvenenje v ušesu (tinitus), prehodna izguba sluha (zlasti visokih frekvenc); - pospešen srčni utrip (tahikardija); - omedlevica (sinkopa), širjenje krvnih žil (vazodilatacija); - zasoplost (dispneja), otekanje grla (larinksa) s težavami pri dihanju (edem grla); - huda in neprekinjena driska, s krvjo in sluzjo ali brez njiju, zaradi hudega vnetja debelega črevesa (psevdomembranski kolitis), glivična okužba v ustih (oralna kandidoza); - porumenelost kože in beločnic (ikterus), zlatenica zaradi bolezni, pri kateri žolč ne more normalno teči iz jeter (holestatski ikterus), nekroza jetrnih celic; - povečana občutljivost za svetlobo (fotosenzitivnost), multiformni eritem in nodozni eritem; - bolečine v mišicah (mialgija), bolezni sklepov (otekanje sklepov); - akutna ledvična odpoved, nenormalno delovanje ledvic, izcedek iz nožnice zaradi glivične okužbe (vaginalna kandidoza), kri v urinu (hematurija), prisotnost kristalov v urinu z neprijetnim občutkom pri uriniranju (kristalurija), vnetje ledvic s krvjo v urinu, zvišano telesno temperaturo in stransko bolečino (intersticijski nefritis); - potenje.