natgillin/translations-raw huggingface dataset:
The following additional risk minimisation measures are necessary for the safe and effective use of the product:
Za varno in učinkovito uporabo zdravila so nujni naslednji dodatni ukrepi za zmanjševanje tveganj: Izobraževalno gradivo za zdravstvene delavce, ki bo omogočalo usposabljanje za ustrezno uporabo zdravila in zmanjševanje tveganj ter ki bo zajemalo ključne elemente za:
• Remove the scarred surface of the cornea
• odstranil zabrazgotinjeno površino roženice • jo zamenjal z zdravilom Holoclar
OTHER SPECIAL WARNING(S), IF NECESSARY Potentially infected biological material.
DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA
Conjunctival haemorrhage, eye haemorrhage, corneal epithelium defect, eye pain, glaucoma/intraocular pressure increased, ulcerative keratitis
glavkom/zvišan očesni tlak, ulcerozni keratitis pogosti adhezija veznice, hiperemija veznice, edem roženice, perforacija roženice, draženje očesa, fotofobija občasni
• Severe dry eye.
• huda oblika suhega očesa
Eye disorders
(šarenico) očesa.
It is the rim surrounding the coloured centre (iris) of your eye.
To je obroč, ki obkroža obarvano sredino
Syncope vasovagal
Bolezni živčevja vazovagalna sinkopa občasni
Pharmacotherapeutic group: Ophthalmologicals, other ophthalmologicals, ATC code: S01XA19 Mechanism of action and pharmacodynamic effects The mechanism of action of Holoclar is the replacement of corneal epithelium and lost limbal stem cells in patients in which the limbus has been destroyed by ocular burns.
Mehanizem delovanja zdravila Holoclar je nadomestitev roženičnega epitelija in izgubljenih limbusnih matičnih celic pri bolnikih, pri katerih je bil limbus uničen ob opeklini očesa.
MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS SCREW-CAP CONTAINER
PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA MANJŠIH STIČNIH
The recommended dose of Holoclar is 79,000 - 316,000 cells/cm², corresponding to 1 cm² of product/cm² of defect.
79.000 - 316.000 celic/cm˛, kar ustreza 1 cm˛ zdravila/cm˛ okvare.
MANUFACTURER OF THE BIOLOGICAL ACTIVE SUBSTANCE AND MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
Ime in naslov izdelovalca, odgovornega za sproščanje serij
Pregnancy and breast-feeding
- tveganje za glavkom in blefaritis
Infections and infestations
Klinična učinkovitost in varnost
• Increased pressure in the eye (glaucoma)
• zvišan očesni tlak (glavkom) • bolečina v očesu
SPECIFIC OBLIGATION TO COMPLETE POSTAUTHORISATION MEASURES FOR THE CONDITIONAL MARKETING AUTHORISATION
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z
In small children this can be 4 to 6 times per day.
Pri majhnih otrocih je to lahko 4- do 6-krat na dan.
Make sure that there are at least 3 hours between two doses.
Prepričajte se, da so minile najmanj tri ure med dvema odmerkoma.
Your doctor will tell you the amount of granules you should take.
Vaš zdravnik vam bo povedal, kakšno količino zrnc morate vzeti.
A risk to the newborns/infants cannot be excluded.
Tveganja pri novorojenčkih/dojenčkih ni mogoče izključiti.
The patient recovered within 48 hours after symptomatic treatment.
Bolnik si je opomogel v 48 urah po simptomatičnem zdravljenju.
It is especially important to tell your doctor if you are taking medicines containing:
Zlasti pomembno je, da obvestite svojega zdravnika, če jemljete zdravila, ki vsebujejo:
Take the correct amount as prescribed by your doctor.
Vzemite pravilno količino, kot vam jo je predpisal vaš zdravnik;
The effect of food on absorption is unknown.
Učinek hrane na absorpcijo ni znan.
To measure the dose:
Za odmerjanje odmerka:
The total daily dose should be divided into equal amounts and given with each meal or feeding (e.g. 4-6 times per day in small children).
Celokupni dnevni odmerek naj se razdeli na enake dele in se daje z vsakim obrokom ali hranjenjem (npr. 4-6 krat dnevno pri majhnih otrocih).
It is important that the diagnosis is made early and treatment is initiated immediately to improve the survival and the clinical outcome.
Pomembno je, da se diagnoza postavi zgodaj in da se zdravljenje takoj prične, saj se s tem izboljša preživetje in klinični izid.
You should take a dose as soon as possible with your next meal.
Vzemite odmerek takoj, ko je možno, z naslednjim obrokom.
The safety and efficacy of doses in excess of 20 g/day have not been established.
Varnost in učinkovitost odmerkov, večjih od 20 g/dan, še ni bila dokazana.
Date of first authorisation: 31 July 2013 Date of latest renewal: 23 March 2018
Datum zadnjega podaljšanja: 23. marec 2018
Talk to your doctor for the details.
O podrobnostih se pogovorite s svojim zdravnikom.
If you mix them with food, it is important that you take it immediately.
Če jih zmešate s hrano, je pomembno, da jih zaužijete takoj.
This will keep the granules from producing any taste.
Tako zrnca ne bodo razvila okusa.
Lucane Pharma 172 rue de Charonne 75011 Paris France
Lucane Pharma 172 rue de Charonne 75011 Pariz Francija
Common depression, irritability
Pogosti depresija, razdražljivost
The elimination half-life was estimated to be 0.8 hours.
Ocenjeno je bilo, da je razpolovni čas izločanja 0,8 ure.
If this happens you will develop symptoms such as feeling sick (nausea), being sick (vomiting), confusion and will need to get urgent medical help.
Če pride do tega, se bodo pojavili simptomi, kot so siljenje na bruhanje (navzea), bruhanje, zmedenost, in potrebovali boste nujno medicinsko pomoč.
• 9.9 - 13.0 g/m2/day in children weighing more than 20 kg, adolescents and adults.
• 9,9-13,0 g/m2/dan pri otrocih, ki tehtajo več kot 20 kg, ter pri mladostnikih in odraslih.
Nitrogen is a building block of proteins, which are an essential part of the food we eat.
Dušik je gradnik beljakovin, ki so bistveni del naše prehrane.
If caloric supplementation is indicated, a protein-free product is recommended.
Če je indicirano kalorično dopolnjevanje prehrane, priporočamo izdelke brez beljakovin.
Talk to your doctor or pharmacist if you need 3 or more grams daily for a prolonged period, especially if you have been advised to follow a low salt (sodium) diet.
Posvetujte se z zdravnikom ali farmacevtom, če potrebujete 3 ali več gramov dnevno v daljšem časovnem obdobju, , še posebno če so vam svetovali dieto z manjšim vnosom soli (natrija)
She recovered following dose reduction except for recurrent pancreatitis episodes that eventually prompted treatment discontinuation.
Po zmanjšanju odmerka je okrevala, z izjemo ponavljajočih se epizod pankreatitisa, zaradi katerih so zdravljenje končno prekinili.
In the event of an overdose, the treatment should be discontinued and supportive measures be instituted.
V primeru prevelikega odmerjanja je treba nemudoma prekiniti z zdravljenjem in izvesti podporne ukrepe.
Haemodialysis or peritoneal dialysis may be beneficial.
Hemodializa ali peritonealna dializa sta lahko koristni.
• Pour granules directly into the spoon as shown by the picture (on the outer carton and at the end of/page 2 of this leaflet)
• zrnca stresite neposredno na žličko, kot kaže slika (na zunanji ovojnini in na koncu strani 2 tega navodila);
It is indicated in all patients with neonatal-onset disease (complete enzyme deficiencies, presenting within the first 28 days of life).
Indicirano je pri vseh bolnikih, pri katerih se bolezen pojavi v neonatalnem obdobju (popolno pomanjkanje encimov, ki se pokaže v prvih 28 dneh življenja).
• suffer from congestive heart failure (a type of heart disease where the heart cannot pump enough blood around the body) or a decrease in your kidney function.
• imate kongestivno srčno popuščanje (vrsta srčnega obolenja, pri kateri srce ne more črpati zadostne količine krvi po telesu) ali če imate zmanjšano delovanje ledvic;
Distribution The volume of distribution of phenylbutyrate is 0.2 l/kg.
Porazdelitev Volumen porazdelitve fenilbutirata je 0,2 l/kg.
Patients with neonatal-onset disease had a high incidence of mental retardation.
Bolniki z neonatalnim pojavom bolezni so imeli visoko pojavnost umske zaostalosti.
These medicines may change the effect of PHEBURANE and you will need more frequent blood tests.
Ta zdravila lahko spremenijo delovanje zdravila PHEBURANE in boste morali pogosteje na krvne preiskave.
• 450 - 600 mg/kg/day in neonates, infants and children weighing less than 20 kg
• 450-600 mg/kg/dan pri novorojenčkih, dojenčkih in otrocih, ki tehtajo manj kot 20 kg,
• valproate (an antiepileptic medicine),
• valproat (zdravilo proti epilepsiji)
These rare disorders are due to a deficiency of certain liver enzymes which are necessary to eliminate waste nitrogen in the form of ammonia.
Do teh redkih motenj prihaja zaradi pomanjkanja določenih encimov v jetrih, ki so potrebni za odstranjevanje odpadnega dušika v obliki amoniaka.
Plasma glutamine should be maintained at levels less than 1,000 μmol/L.
Plazemske koncentracije glutamina je treba vzdrževati pod 1000 µmol/l.
• worsening of existing neurological conditions.
• težave s spominom • poslabšanje obstoječih nevroloških stanj
If you need laboratory tests, it is important to remind your doctor that you are taking PHEBURANE, since sodium phenylbutyrate may interfere with certain laboratory test results (such as blood electrolytes or protein, or liver function tests)
Če boste morali opraviti laboratorijske preiskave, je pomembno, da opomnite svojega zdravnika, da jemljete zdravilo PHEBURANE, ker lahko natrijev fenilbutirat vpliva na rezultate nekaterih laboratorijskih preiskav (kot so npr. elektroliti ali beljakovine v krvi ali pa vrednosti jetrnih preiskav).
If you experience any of these symptoms, you should immediately contact your doctor or the nearest hospital emergency department for supportive treatment.
Če pri sebi opazite katerega teh simptomov, nemudoma obvestite svojega zdravnika ali najbližjo nujno medicinsko pomoč za podporno zdravljenje.
This should be taken into account if you have diabetes mellitus.
To morate upoštevati, če imate sladkorno bolezen.
If this occurs, please discuss it with your doctor, because the absence of your period may be caused by pregnancy (see ‘Pregnancy and breast-feeding' section above) or by menopause.
Če se to zgodi, se posvetujete s svojim zdravnikom, ker lahko izostanek menstruacije pomeni, da ste noseči (glejte poglavje „Nosečnost in dojenje“ zgoraj).
• disorientation,
• dezorientiranost
Very common side effects (may affect more than 1 in 10 people): irregular menstrual periods and stopping of menstrual periods in fertile women.
Zelo pogosti neželeni učinki (pojavijo se lahko pri več kot 1 od 10 bolnikov): neredna menstruacija in izostanek menstruacije pri plodnih ženskah.
You will need to take this medicine and to follow a diet throughout your life.
To zdravilo in posebno prehrano boste potrebovali celo življenje.
If you are sexually active and your period stops altogether, do not assume that this is caused by PHEBURANE.
Če ste spolno dejavni in vam menstruacija izostane, ne domnevajte, da gre za učinke zdravila PHEBURANE.
<1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Pogostnost neželenih učinkov je opredeljena kot zelo pogosti (≥1/10), pogosti (≥1/100 do <1/10), občasni (≥1/1.000 do <1/100), redki (≥ 1/10.000 do < 1/1 000), zelo redki (< 1/10 000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
Women of childbearing potential must use effective contraception during treatment.
Ženske v rodni dobi morajo med zdravljenjem uporabljati učinkovito kontracepcijo.
If persistent vomiting occurs, you should contact your doctor immediately.
Če pride do trdovratnega bruhanja, nemudoma obvestite svojega zdravnika.
• are allergic to sodium phenylbutyrate or any of the other ingredients of this medicine (listed in section 6).
• če ste alergični na natrijev fenilbutirat ali katero koli sestavino tega zdravila (navedeno v poglavju 6);
Phenylacetate is also hydrolysed by esterases in liver and blood.
Fenilacetat hidrolizirajo tudi esteraze v jetrih in krvi.
Therapeutic monitoring
Nadzorovanje zdravljenja
Manifestations of neurotoxicity were predominantly somnolence, fatigue and light-headedness.
Znaki nevrotoksičnosti so bili predvsem somnolenca, utrujenost in omotičnost.
• Tap the spoon once on a table to give a horizontal level of granules and continue filling if necessary
• enkrat potolcite z žličko po mizi, da se bodo zrnca vodoravno poravnala in po potrebi nadaljujte polnjenje.
• probenecid (for treatment of hyperuricaemia, high levels of uric acid in the blood, associated with gout)
• probenecid (za zdravljenje hiperurikemije, visokih ravni sečne kisline v krvi, ki so povezane s protinom).
Adverse reactions mainly involved the reproductive and gastrointestinal system.
Neželeni učinki so prizadeli predvsem reproduktivni in prebavni sistem.
The daily dose should be individually adjusted according to the patient's protein tolerance and the daily dietary protein intake needed to promote growth and development.
Dnevni odmerek je treba prilagoditi individualno glede na bolnikovo toleranco za beljakovine in na potreben dnevni vnos beljakovin za pospeševanje rasti in razvoja.
Each carton contains 1 bottle.
Vsaka škatlica vsebuje 1 plastenko.
PHEBURANE will not prevent the occurrence of an acute excess of ammonia in the blood, a condition which usually constitutes a medical emergency.
Zdravilo PHEBURANE ne prepreči nastanka akutnega presežka amonijaka v krvi, stanja, ki običajno pomeni nujno medicinsko pomoč.
• PHEBURANE is not recommended for the management of acute hyperammonaemia, which is a medical emergency.
• Zdravila PHEBURANE ne priporočajo za zdravljenje akutne hiperamonemije, ki je medicinski nujen primer.
Less frequent manifestations were confusion, headache, dysgeusia, hypoacusis, disorientation, impaired memory and exacerbation of a pre-existing neuropathy.
Manj pogosti znaki nevrotoksičnosti pa so bili zmedenost, glavobol, disgevsija, hipakuza, dezorientacija, poslabšanje spomina in poslabšanje že obstoječih nevropatij.
Reversal of pre-existing neurologic impairment is not likely to occur with treatment, and neurologic deterioration may continue in some patients.
Z zdravljenjem ni verjetno, da bi prišlo do izboljšanja obstoječih nevroloških motenj, pri nekaterih bolnikih pa se lahko tudi nadaljuje slabšanje nevroloških stanj.
Do not use PHEBURANE after the expiry date which is stated on the carton and the bottle label after EXP.
Zdravila PHEBURANE ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in nalepki na plastenki poleg oznake “EXP”.
PHEBURANE may be required life-long unless orthotropic liver transplantation is elected.
Zdravljenje z zdravilom PHEBURANE je lahko potrebno celo življenje, če ne pride do odločitve za ortotopično presaditev jeter.
• Lines on the spoon indicate the amount (in gram of sodium phenylbutyrate).
• črtice na žlički prikazujejo količino (v gramih natrijevega fenilbutirata).
In patients diagnosed during gestation and treated prior to any episode of hyperammonaemic encephalopathy, survival was 100 %, but even in these patients, many subsequently demonstrated cognitive impairment or other neurologic deficits.
Pri bolnikih, katerim so diagnozo postavili v času nosečnosti in so bili zdravljeni pred epizodo hiperamoniemične encefalopatije, je bilo preživetje 100 %, toda tudi pri velikem deležu teh bolnikov so kasneje odkrili kognitivne motnje ali druge nevrološke pomanjkljivosti.
One case of overdose occurred in a 5-month old infant with an accidental single dose of 10 g (1370 mg/kg).
Do prevelikega odmerjanja je prišlo pri petmesečnem dojenčku z naključnim zaužitjem enkratnega odmerka 10 g (1 370 mg/kg).
You must follow this diet carefully.
Navodila glede prehrane morate zelo skrbno upoštevati.
The usual total daily dose of sodium phenylbutyrate in clinical experience is:
Običajni celokupni dnevni odmerek natrijevega fenilbutirata je po kliničnih izkušnjah:
Pharmacotherapeutic group: Other alimentary tract and metabolism products, various alimentary tract and metabolism products, ATC code: A16AX03.
Farmakoterapevtska skupina: druga zdravila za bolezni prebavil in presnove, razna zdravila za bolezni prebavil in presnove, oznaka ATC: A16AX03.
Micronucleus test results indicate that sodium phenylbutyrate was considered not to have produced any clastogenic effect in rats treated at toxic or non-toxic dose levels (examined 24 and 48 hours after a single oral administration of 878 to 2800 mg/kg).
Rezultati mikronukleusnega preskusa kažejo, da natrijev fenilbutirat ni proizvedel klastogenih učinkov pri podganah, katerim je bil dajan v toksičnih in netoksičnih odmerkih (preverjano po 24 in 48 urah po enkratnem peroralnem odmerku 878 do 2 800 mg/kg).
You should take PHEBURANE with each meal or feeding.
Zdravilo PHEBURANE morate vzeti ob vsakem obroku oz. prehranjevanju.
There have been published reports of hyperammonaemia being induced by haloperidol and by valproate.
Objavljena so poročila o hiperamonemiji, sproženi s haloperidolom in z valproatom.
Common syncope, headache
Pogosti sinkopa, glavobol
Do not use PHEBURANE if you are breast-feeding, because this medicine can pass into the breast milk and may harm your baby.
Ne jemljite zdravila PHEBURANE, če dojite, ker lahko prehaja v mleko in lahko škoduje vašemu otroku.
Sodium phenylbutyrate was negative in 2 mutagenicity tests, i.e. the Ames test and the micronucleus test.
Natrijev fenilbutirat je dal negativne rezultate v dveh preskusih mutagenosti, tj. v Amesovem preskusu in v mikronukleusnem preskusu.
Their cognitive performance remained relatively stable during phenylbutyrate therapy.
Njihove kognitivne sposobnosti pa so med zdravljenjem z fenilbutiratom ostajale sorazmerno stabilne.
Contents of the pack and other information What PHEBURANE contains
Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo PHEBURANE
• This medicinal product contains 768 mg sucrose per gram.
• To zdravilo vsebuje 768 mg saharoze na gram.
With haemodialysis, use of alternative waste nitrogen excretion pathways (sodium phenylbutyrate, sodium benzoate and sodium phenylacetate), dietary protein restriction, and, in some cases, essential amino acid supplementation, the survival rate in newborns diagnosed after birth (but within the first month of life) increased to almost 80 % with most deaths occurring during an episode of acute hyperammonaemic encephalopathy.
S hemodializo, uporabo alternativnih poti izločanja odpadnega dušika (natrijev fenilbutirat, natrijev benzoat in natrijev fenilacetat), omejevanjem prehranskega vnosa beljakovin in (v določenih primerih) dopolnili esencialnih aminokislin se je stopnja preživetja pri novorojenčkih s postavitvijo diagnoze v prvem mesecu življenja povečala na skoraj 80 %, pri čemer do večine smrti pride med epizodo hiperamoniemične encefalopatije.
Pheburane is contra-indicated during pregnancy (see section 4.3).
Zdravilo Pheburane je kontraindicirano v nosečnosti (glejte poglavje 4.3).
In clinical trials with sodium phenylbutyrate, 56 % of the patients experienced at least one adverse event and 78 % of these adverse events were considered as not related to sodium phenylbutyrate.
V kliničnih preskušanjih z natrijevim fenilbutiratom je 56 % bolnikov doživelo najmanj en neželeni učinek, vendar se za 78 % teh neželenih učinkovšteje, da niso povezani z natrijevim fenilbutirat.
The mean time to peak concentration was 1 hour and the mean peak concentration 195 μg/ml.
Povprečni čas do najvišje koncentracije je bil 1 ura, povprečna najvišja koncentracija pa 195 µg/ml.
It is also indicated in patients with late-onset disease (partial enzyme deficiencies, presenting after the first month of life) who have a history of hyperammonaemic encephalopathy.
Indicirano je tudi pri bolnikih, pri katerih se bolezen pojavi s t.i. zakasnjenim pojavom (delno pomanjkanje encimov, ki se pokaže po prvem mesecu življenja) in imajo anamnezo hiperamonemične encefalopatije.
• have decreased kidney or liver function, since PHEBURANE is eliminated from the body through the kidney and liver.
• imate zmanjšano delovanje ledvic ali jeter, ker se zdravilo PHEBURANE odstranjuje iz telesa prek ledvic in jeter.
Plasma levels of ammonia, arginine, essential amino acids (especially branched chain amino acids), carnitine and serum proteins should be maintained within normal limits.
Plazemske koncentracije amoniaka, arginina, esencialnih aminokislin (predvsem aminokislin z razvejano verigo), karnitina in serumskih beljakovin je treba vzdrževati v normalnih mejah.
Results indicate that sodium phenylbutyrate did not induce any mutagenic effects in the Ames test with or without metabolic activation.
Rezultati kažejo, da natrijev fenilbutirat ni sprožil mutagenih učinkov v Amesovem preskusu niti s presnovno aktivacijo niti brez nje.
What PHEBURANE is and what it is used for
Kaj je zdravilo PHEBURANE in za kaj ga uporabljamo
On a molar basis, phenylacetylglutamine is comparable to urea (each containing 2 moles of nitrogen) and therefore provides an alternate vehicle for waste nitrogen excretion.
Po molskih razmerjih je fenilacetilglutamin primerljiv s sečnino (oba vsebujeta 2 mola dušika) in je zato lahko alternativen nosilec za izločanje odpadnega dušika.
In patients with impaired hepatic function the conversion of phenylacetate to phenylacetylglutamine may be relatively slower.
Pri bolnikih z motnjami v delovanju jeter je lahko pretvorba fenilacetata v fenilacetilglutamin sorazmerno počasnejša.
This should be particularly taken into account for those on a low salt diet.
To je treba posebej skrbno upoštevati pri bolnikih na dieti z zmanjšanim vnosom soli.
Only use this measuring spoon to measure out the dose.
Za odmerjanje odmerka uporabljajte le to odmerno žličko.
Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicinal product.
To je treba upoštevati pri bolnikih s sladkorno boleznijo.. Bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali pomanjkanjem saharoza-izomaltaze ne smejo jemati tega zdravila.
PHEBURANE has negligible influence on the ability to drive and use machines.
Zdravilo PHEBURANE ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
PHEBURANE treatment should be supervised by a physician experienced in the treatment of urea cycle disorders.
Zdravljenje z zdravilom PHEBURANE naj nadzoruje zdravnik, ki je izkušen pri zdravljenju motenj ciklusa sečnine.
The majority of the patients who were tested had an IQ in the average to low average/borderline mentally retarded range.
Vrednosti IQ večine bolnikov, ki so bili testirani, so bile v območju povprečja do nizkega povprečja oz. mejnih vrednosti umske zaostalosti.
Corticosteroids may cause the breakdown of body protein and thus increase plasma ammonia levels.
Kortikosteroidi lahko povzročijo razgradnjo telesnih beljakovin in s tem povečanje plazemskih koncentracij amoniaka.
Contains sodium and sucrose.
Vsebuje natrij in saharozo.
A probable case of toxic reaction to sodium phenylbutyrate (450 mg/kg/d) was reported in an 18year old anorectic female patient who developed a metabolic encephalopathy associated with lactic acidosis, severe hypokalaemia, pancytopaenia, peripheral neuropathy, and pancreatitis.
Poročali so o verjetnem primeru toksične reakcije na natrijev febilbutirat (450 mg/kg/d) pri 18-letni anorektični bolnici, pri kateri se je razvila metabolična encefalopatija, povezana z laktično acidozo, težko hipokaliemijo, pancitopenijo, periferno nevropatijo in pankreatitisom.
Previously, neonatal-onset presentation of urea cycle disorders was almost universally fatal within the first year of life, even when treated with peritoneal dialysis and essential amino acids or their nitrogen-free analogues.
Včasih so bile motnje ciklusa sečnine z neonatalnim pojavom skoraj brez izjeme smrtne v prvem letu življenja, navkljub zdravljenju s peritonealno dializo in esencialnimi aminokislinami ali njihovimi analogi brez dušika.
If you forget to take PHEBURANE
Če ste pozabili vzeti zdravilo PHEBURANE
In the table below all adverse reactions are listed below, by system organ class and by frequency.
Neželeni učinki so navedeni v spodnji preglednici, razvrščeni po organskih sistemih in pogostnosti.