natgillin/translations-raw huggingface dataset:
In patients with type 2 diabetes mellitus, LUSDUNA can also be given together with oral antidiabetic medicinal products.
Pri bolnikih s sladkorno boleznijo tipa 2 se zdravilo LUSDUNA lahko uporablja skupaj s peroralnimi antidiabetiki.
Don't use your pen if it has been removed from the refrigerator for more than 28 days.
Injekcijskega peresnika ne uporabljajte, če ste ga iz hladilnika vzeli pred več kot 28 dnevi.
The patient's ability to concentrate and react may be impaired as a result of hypoglycaemia or hyperglycaemia or, for example, as a result of visual impairment.
Bolnikova zmožnost koncentracije in reagiranja se lahko poslabša zaradi hipoglikemije ali hiperglikemije ali npr. zaradi okvare vida.
You may need to talk about: - the availability of your insulin in the country you are visiting, - supplies of insulin, syringes etc., - correct storage of your insulin while travelling, - timing of meals and insulin administration while travelling, - the possible effects of changing to different time zones, - possible new health risks in the countries to be visited, - what you should do in emergency situations when you feel unwell or become ill.
Med drugim se boste morali z njim pogovoriti o: - razpoložljivosti svojega insulina v državi, v katero se odpravljate, - zalogah insulina, injekcijskih brizg itd., - pravilnem shranjevanju insulina med potovanjem, - časovnem razporedu obrokov in dajanja insulina na potovanju, - možnih vplivih spremembe časovnih pasov, - možnih novih zdravstvenih tveganjih v državah, ki jih boste obiskali, - ukrepih v nujnih primerih, če se ne počutite dobro ali zbolite.
• Do not put it back in the refrigerator or freeze.
• Ne dajajte ga nazaj v hladilnik in ga ne zamrznite.
Deliver the dose by pressing the injection button until you see 0 and a green stripe appears in the window.
Odmerek injicirajte tako, da pritiskate gumb za injiciranje, dokler ne zagledate 0 in se v okencu pokaže zelena črta.
OUTER CARTON (with blue box) multipack - 10 (2 x 5)
ZUNANJA ŠKATLA (z modrim okencem) multi pakiranje - 10 (2 x 5)
Check the cartridge to make sure the insulin is clear, colourless and free of particles.
Preverite vložek in se prepričajte, da je insulin bister, brezbarven in brez delcev.
Mean dose of insulin glargine by study end was 0.42 U/kg.
Povprečni odmerek insulina glargin je bil na koncu študije 0,42 enot/kg.
The Nexvue pen delivers LUSDUNA in increments of 1 unit up to a maximum single dose of 60 units.
Injekcijski peresnik Nexvue omogoča povečevanje odmerkov zdravila LUSDUNA po 1 enoto do največjega enkratnega odmerka 60 enot.
This medicinal product contains less than 1 mmol (23 mg) sodium per dose, i.e., essentially “sodium-free”.
To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni "brez natrija".
Insulin glargine did not alter the relative risk for CV disease and CV mortality when compared to standard of care.
Insulin glargin v primerjavi s standardnim zdravljenjem ni spremenil relativnega tveganja za CV bolezni ali CV umrljivost.
It is advisable to test your blood sugar immediately after taking glucose to check that you really have hypoglycaemia.
Takoj po zaužitju glukoze je priporočljivo izmeriti krvni sladkor, da preverite, ali gre res za hipoglikemijo.
There were no differences between insulin glargine and standard care for the two co-primary outcomes; for any component endpoint comprising these outcomes; for all-cause mortality; or for the composite microvascular outcome.
Med insulinom glargin in standardnim zdravljenjem ni bilo razlik glede obeh soprimarnih izidov, glede nobene komponente opazovanega dogodka, ki je obsegal te izide, glede umrljivosti zaradi vseh vzrokov ali glede sestavljenega mikrovaskularnega izida.
Every time you inject you need to do a small test dose to make sure your pen is working.
Pred vsakim injiciranjem morate opraviti preizkus z majhnim testnim odmerkom, da se prepričate, če injekcijski peresnik deluje.
LUSDUNA and medicinal products containing insulin glargine 300 units/mL are not bioequivalent and are not directly interchangeable.
Zdravilo LUSDUNA in zdravila, ki vsebujejo insulin glargin 300 enot/ml, niso bioekvivalentna in niso neposredno medsebojno zamenljiva.
Pens in use must not be stored in the refrigerator.
Injekcijskih peresnikov, ki so v uporabi, se ne sme shranjevati v hladilniku.
Insulin overdose may lead to severe and sometimes long-term and life-threatening hypoglycaemia.
Preveliko odmerjanje insulina lahko povzroči hudo ter včasih dolgotrajno in življenjsko nevarno hipoglikemijo.
Before first use, the pen must be stored at room temperature for 1 to 2 hours to allow it to warm up.
Pred prvo uporabo mora biti injekcijski peresnik 1 do 2 uri na sobni temperaturi, da se segreje.
Press to inject into the air
Pritisnite, da boste injicirali v zrak
Factors increasing the susceptibility to hypoglycaemia require particularly close monitoring and may necessitate dose adjustment.
V primeru dejavnikov, ki povečujejo dovzetnost za hipoglikemijo, je potrebno posebno skrbno spremljanje in morda prilagoditev odmerka.
Pre-filled pens in use or carried as a spare may be stored for a maximum of 28 days up to 30°C and away from direct heat and direct light.
Napolnjene injekcijske peresnike, ki jih uporabljate ali nosite s seboj za rezervo, lahko shranjujete največ 28 dni pri temperaturi do 30 °C in zaščitene pred neposredno vročino in svetlobo.
Thirst, increased need to urinate, tiredness, dry skin, reddening of the face, loss of appetite, low blood pressure, fast heartbeat, and glucose and ketone bodies in urine.
Žeja, pogostejša potreba po uriniranju, utrujenost, suha koža, pordelost obraza, izguba apetita, nizek krvni tlak, hitro bitje srca ter prisotnost glukoze in ketonskih teles v urinu.
Generally, the greater and more rapid the decline in blood glucose, the more marked is the phenomenon of counter-regulation and its symptoms (see section 4.4).
Praviloma so pojav protiregulacije in njegovi simptomi toliko izrazitejši, kolikor večje in hitrejše je znižanje koncentracije glukoze v krvi (glejte poglavje 4.4).
Severe allergic reactions (rare, may affect up to 1 in 1,000 people) - the signs may include largescale skin reactions (rash and itching all over the body), severe swelling of skin or mucous membranes (angioedema), shortness of breath, a fall in blood pressure with rapid heartbeat and sweating.
Hude alergijske reakcije (redke, pojavijo se lahko pri največ 1 od 1.000 bolnikov) - znaki lahko vključujejo obsežne kožne reakcije (izpuščaj in srbenje po celem telesu), hudo oteklost kože ali sluznic (angioedem), kratko sapo, padec krvnega tlaka s hitrim bitjem srca in znojenje.
Always check you have the right pen.
Vedno preverite, da imate pravi injekcijski peresnik.
Such reactions to insulin (including insulin glargine) or the excipients may, for example, be associated with generalised skin reactions, angio-oedema, bronchospasm, hypotension and shock, and may be life-threatening.
Takšne reakcije na insulin (tudi na insulin glargin) ali pomožne snovi so lahko na primer povezane z generaliziranimi kožnimi reakcijami, angioedemom, bronhospazmom, hipotenzijo in šokom, ter so lahko življenjsko nevarne.
Insulin and its analogues lower blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production.
Insulin in njegovi analogi zmanjšajo koncentracijo glukoze v krvi s spodbujanjem perifernega privzema glukoze, zlasti v skeletnih mišicah in maščevju, in z zaviranjem nastajanja glukoze v jetrih.
Empty pens must never be reused and must be properly discarded.
Praznih injekcijskih peresnikov se ne sme nikoli ponovno uporabiti in jih je treba ustrezno zavreči.
Pharmacotherapeutic group: Drugs used in diabetes, insulins and analogues for injection, long-acting.
Farmakoterapevtska skupina: zdravila za zdravljenje diabetesa, insulini za injiciranje z dolgotrajnim delovanjem in analogi.
Empty pens must not be re-filled and must be properly discarded.
Praznih peresnikov se ne sme ponovno polniti in jih je treba ustrezno zavreči.
Important information about some of the ingredients of LUSDUNA This medicine contains less than 1 mmol (23 mg) sodium per dose, i.e. it is essentially ‘sodium-free'.
Pomembne informacije o nekaterih sestavinah zdravila LUSDUNA To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na odmerek, kar v bistvu pomeni "brez natrija".
Hypoglycaemia (very common), in general the most frequent adverse reaction of insulin therapy, may occur if the insulin dose is too high in relation to the insulin requirement (see section 4.4).
Hipoglikemija (zelo pogosta), na splošno najpogostejši neželeni učinek pri zdravljenju z insulinom, se lahko pojavi, če je odmerek insulina prevelik glede na potrebo po insulinu (glejte poglavje 4.4).
One hundred forty three of the patients treated with insulin glargine in this study continued treatment with insulin glargine in an uncontrolled extension study with mean duration of follow-up of 2 years.
Stotriinštirideset bolnikov, ki so v tej študiji prejemali insulin glargin, je zdravljenje z njim nadaljevalo v nekontrolirani podaljšani študiji, v kateri je povprečno spremljanje trajalo 2 leti.
INTERMEDIATE CARTON (without blue box) component of a multipack - 5 pens
VMESNA ŠKATLA (brez modrega okenca) del multi pakiranja - 5 peresnikov
In clinical studies, subgroup analyses based on age and gender did not indicate any difference in safety and efficacy in insulin glargine-treated patients compared to the entire study population.
Analize podskupin po starosti in spolu v kliničnih študijah niso pokazale razlik glede varnosti in učinkovitosti pri bolnikih, zdravljenih z insulinom glargin, v primerjavi s celotno raziskovano populacijo.
If you have proliferative retinopathy (an eye disease related to diabetes) severe hypoglycaemic attacks may cause temporary loss of vision.
Če imate proliferativno retinopatijo (očesno bolezen, povezano s sladkorno boleznijo), lahko hude hipoglikemije povzročijo prehodno izgubo vida.
Other medicines and LUSDUNA
Druga zdravila in zdravilo LUSDUNA
In such a case, you may develop severe hypoglycaemia (and even faint) before you are aware of the problem.
V takšnem primeru se lahko pojavi huda hipoglikemija (in celo nezavest), še preden se sploh zaveste, da je kaj narobe.
After the injection Be careful not to stick your finger with the needle.
Po injiciranju Pazite, da se z iglo ne zbodete v prste.
The primary aim of demonstrating non-inferiority of insulin glargine to NPH in all hypoglycaemia was not met and there was a trend to an increase of hypoglycaemic events with insulin glargine [insulin glargine: NPH rate ratio (95 % CI) = 1.18 (0.97-1.44)].
Primarni cilj, dokazati neinferiornost insulina glargin v primerjavi z insulinom NPH pri vseh hipoglikemijah, ni bil dosežen in opazen je bil trend povečanja hipoglikemičnih dogodkov z insulinom glargin [razmerje deležev insulin glargin:NPH (95 % IZ) = 1,18 (0,97-1,44)].
OUTER CARTON - Packs of 1 and 5
ZUNANJA ŠKATLA - pakiranja po 1 in po 5
If you inject your insulin too often at the same skin site, fatty tissue under the skin at this site may either shrink (lipoatrophy, may affect up to 1 in 100 people) or thicken (lipohypertrophy).
Če si insulin prepogosto injicirate na isto mesto, se podkožno maščevje na tem mestu lahko skrči (lipoatrofija, pojavi se lahko pri največ 1 od 100 bolnikov) ali zadebeli (lipohipertrofija).
In case of insufficient glucose control or a tendency to hyper- or hypoglycaemic episodes, the patient's adherence to the prescribed treatment regimen, injection sites and proper injection technique and all other relevant factors must be reviewed before dose adjustment is considered.
V primeru nezadostne urejenosti glukoze ali nagnjenosti k hiper- ali hipoglikemijam, je treba pred spreminjanjem odmerka preveriti, kako se bolnik drži predpisane sheme zdravljenja, mesta injiciranja in ustrezne tehnike injiciranja ter vse druge dejavnike, ki spadajo zraven.
Although LUSDUNA contains the same active substance as other medicines containing insulin glargine 300 units/ml, these medicines are not interchangeable.
Čeprav zdravilo LUSDUNA vsebuje isto učinkovino kot druga zdravila, ki vsebujejo 300 enot/ml insulina glargin, ta zdravila niso medsebojno zamenljiva.
It is very important that you dial the dose your healthcare provider recommended.
Zelo pomembno je, da nastavite odmerek, ki vam ga je svetoval zdravnik.
Very rare side-effects (may affect up to1 in 10,000 people) In very rare cases, dysgeusia (taste disorders) and myalgia (muscular pain) can occur.
Zelo redki neželeni učinki (pojavijo se lahko pri največ 1 od 10.000 bolnikov) V zelo redkih primerih se lahko pojavijo motnje okušanja (disgevzija) in bolečine v mišicah (mialgija).
Before using Nexvue, the instructions for use included in the pack must be read carefully (see section 6.6).
Pred uporabo injekcijskega peresnika Nexvue je treba natančno prebrati navodila za njegovo uporabo, ki so priložena v pakiranju (glejte poglavje 6.6).
Insulin glargine is a human insulin analogue designed to have a low solubility at neutral pH.
Insulin glargin je analog humanega insulina, zasnovan tako, da je pri nevtralnem pH slabo topen.
Read about this in the Package leaflet supplied in every carton.
O tem si preberite v navodilu za uporabo, priloženem v vsaki škatli.
In addition, under the influence of sympatholytic medicinal products such as beta-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counter-regulation may be reduced or absent.
Poleg tega se lahko pod vplivom simpatikolitičnih zdravil, kot so zaviralci adrenergičnih receptorjev beta, klonidin, gvanetidin in reserpin, znaki adrenergične protiregulacije zmanjšajo ali izginejo.
Due to more sustained basal insulin supply with insulin glargine, less nocturnal but more early morning hypoglycaemia can be expected.
Zaradi enakomernejšega sproščanja bazalnega insulina pri insulinu glargin se lahko pričakuje manj nočnih, a več zgodnjih jutranjih hipoglikemij.
IGF-1 receptor binding: The affinity of insulin glargine for the human IGF-1 receptor is approximately 5 to 8-fold greater than that of human insulin (but approximately 70 to 80-fold lower than the one of IGF-1), whereas M1 and M2 bind the IGF-1 receptor with slightly lower affinity compared to human insulin.
Vezava na receptorje za IGF-1: Afiniteta insulina glargin za človeški receptor IGF-1 je približno 5- do 8-krat večja kot afiniteta humanega insulina (vendar približno 70- do 80-krat manjša kot afiniteta IGF-1), presnovka M1 in M2 pa se na receptor za IGF-1 vežeta z nekoliko manjšo afiniteto kot humani insulin.
Prolonged or severe hypoglycaemic episodes may be life-threatening.
Dolgotrajne ali hude hipoglikemije so lahko življenjsko nevarne.
You need to see the window clearly during the injection.
Med injiciranjem morate okence jasno videti.
Diabetes mellitus is a disease where your body does not produce enough insulin to control the level of blood sugar.
Sladkorna bolezen je bolezen, pri kateri v telesu ne nastaja dovolj insulina, da bi lahko uravnal koncentracijo sladkorja v krvi.
Animal data do not indicate reproductive toxicity.
Podatki na živalih ne kažejo na vpliv na sposobnost razmnoževanja.
In the following situations, the management of your diabetes may require a lot of care (for example, adjustment to insulin dose, blood and urine tests): - If you are ill or have a major injury then your blood sugar level may increase (hyperglycaemia).
V naslednjih primerih lahko obvladovanje sladkorne bolezni zahteva posebno skrb (na primer prilagoditev odmerka insulina, preiskave krvi in urina): - Če zbolite ali imate kakšno večjo poškodbo, se vam koncentracija krvnega sladkorja lahko zviša
Insulin glargine injected once daily will reach steady state levels in 2-4 days after the first dose.
Insulin glargin, injiciran enkrat na dan, doseže koncentracijo v stanju dinamičnega ravnovesja od 2 do 4 dni po prvem odmerku.
Store in a refrigerator (2°C - 8°C).
Shranjujte v hladilniku (2 °C -8 °C).
Throw away the needle safely, as instructed by your doctor, pharmacist or nurse.
Igle varno zavrzite, kot vam je naročil zdravnik, farmacevt ali medicinska sestra.
In patients with proliferative retinopathy, particularly if not treated with photocoagulation, severe hypoglycaemic episodes may result in transient amaurosis.
Pri bolnikih s proliferativno retinopatijo, zlasti če ni zdravljena s fotokoagulacijo, lahko hude hipoglikemije povzročijo prehodno slepoto.
Driving and using machines Your ability to concentrate or react may be reduced if: - you have hypoglycaemia (low blood sugar levels), - you have hyperglycaemia (high blood sugar levels), - you have problems with your sight.
Vpliv na sposobnost upravljanja vozil in strojev Vaša sposobnost koncentracije in reagiranja se lahko zmanjša: - če imate hipoglikemijo (nizko koncentracijo krvnega sladkorja), - če imate hiperglikemijo (visoko koncentracijo krvnega sladkorja), - če imate težave z vidom.
Name and address of the manufacturer(s) responsible for batch release N.V. Organon
Ime in naslov izdelovalca (izdelovalcev), odgovornega (odgovornih) za sproščanje serij N.V.
If you use more than one type of medicine, make sure you have the right medicine before injecting.
Če uporabljate več kot eno vrsto zdravil, se pred injiciranjem vedno prepričajte, da imate pravo zdravilo.
You can give from 1 to 60 units in a single injection.
Z enkratnim injiciranjem lahko daste od 1 do 60 enot.
At baseline, participants had a median HbA1c value of 6.4 % and median on-treatment HbA1c values ranged from 5.9 to 6.4 % in the insulin glargine group, and 6.2 % to 6.6 % in the standard care group throughout the duration of follow-up.
Med zdravljenjem je bila mediana vrednost HbA1c v skupini z insulinom glargin od 5,9 % do 6,4 % in v skupini s standardnim zdravljenjem od 6,2 % do 6,6 % v celotnem obdobju spremljanja.
Serious hypoglycaemia may cause a heart attack or brain damage and may be life-threatening.
Huda hipoglikemija lahko povzroči srčni infarkt ali poškodbo možganov in je lahko življenjsko nevarna.
Dose adjustment may also be required, for example, if the patient's weight or life-style changes, change of timing of insulin dose or other circumstances arise that increase susceptibility to hypo- or hyperglycaemia (see section 4.4).
Prilagoditev odmerka bo morda potrebna tudi, če se npr. spremenijo bolnikova telesna masa ali življenjski slog, čas aplikacije odmerka insulina, ali se pojavijo druge okoliščine, ki povečajo dovzetnost za hipo- ali hiperglikemijo (glejte poglavje 4.4).
• Your pen is usable for up to 28 days after removal from the refrigerator.
• Injekcijski peresnik lahko uporabljate do 28 dni po tem, ko ste ga vzeli iz hladilnika.
Insulin glargine was administered once daily at bedtime and NPH human insulin was administered once or twice daily.
Insulin glargin so prejeli enkrat na dan pred spanjem, humani insulin NPH pa enkrat ali dvakrat na dan.
Intravenous administration of the usual subcutaneous dose could result in severe hypoglycaemia.
Intravenska uporaba običajnega subkutanega odmerka lahko povzroči hudo hipoglikemijo.
In a randomised, controlled clinical study, paediatric patients (age range 6 to 15 years) with type 1 diabetes (n=349) were treated for 28 weeks with a basal-bolus insulin regimen where regular human insulin was used before each meal.
V randomizirani, kontrolirani klinični študiji so pediatrične bolnike (stare od 6 do 15 let) s sladkorno boleznijo tipa 1 (n = 349) 28 tednov zdravili z bazalno-bolusno insulinsko shemo, v kateri so pred vsakim obrokom prejeli običajni humani insulin.
Glycohaemoglobin and glucose variabilities were comparable in both treatment groups.
Glikirani hemoglobin in variabilnost glukoze sta bila med terapevtskima skupinama primerljiva.
If it does not work with a new needle, you will need to speak to your doctor or nurse.
Če ne deluje niti z novo iglo, se boste morali posvetovati z zdravnikom ali medicinsko sestro.
Effects of insulin glargine (once daily) on diabetic retinopathy were evaluated in an open-label 5 year NPH-controlled study (NPH given bid) in 1024 type 2 diabetic patients in which progression of retinopathy by 3 or more steps on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale was investigated by fundus photography.
Učinke insulina glargin (enkrat na dan) na diabetično retinopatijo so ocenili v odprti 5-letni z insulinom NPH nadzorovani študiji (insulin NPH apliciran dvakrat na dan) pri 1.024 bolnikih s sladkorno boleznijo tipa 2, v kateri so napredovanje retinopatije za 3 stopnje ali več po lestvici ETDRS (Early Treatment Diabetic Retinopathy Study) raziskali s slikanjem očesnega ozadja.
Such situations may result in severe hypoglycaemia (and possibly loss of consciousness) prior to the patient's awareness of hypoglycaemia.
V takšnih okoliščinah se huda hipoglikemija (in možna izguba zavesti) lahko pojavi, še preden se bolnik hipoglikemije sploh zave.
In rare cases, the presence of such insulin antibodies may necessitate adjustment of the insulin dose in order to correct a tendency to hyper- or hypoglycaemia (see section 5.1).
V redkih primerih je zaradi prisotnosti takšnih protiteles proti insulinu treba prilagoditi odmerek insulina, da bi odpravili nagnjenost k hiper- ali hipoglikemiji (glejte poglavje 5.1).
• If you use more than one type of medicine, make sure you have the right medicine before
• Če uporabljate več kot eno vrsto zdravil, se pred injiciranjem vedno prepričajte, da imate pravo
No new safety signals were seen during this extended treatment with insulin glargine.
Med tem podaljšanjem zdravljenja z insulinom glargin niso opazili nobenih novih varnostnih signalov.
Sustained carbohydrate intake and observation may be necessary because hypoglycaemia may recur after apparent clinical recovery.
Morda bo potrebno dolgotrajnejše uživanje ogljikovih hidratov in opazovanje, saj se lahko hipoglikemija po navideznem kliničnem izboljšanju ponovi.
The ORIGIN (Outcome Reduction with Initial Glargine INtervention) study was a multicentre, randomised, 2x2 factorial design study conducted in 12,537 participants at high cardiovascular (CV) risk with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) (12 % of participants) or type 2 diabetes mellitus treated with ≤ 1 antidiabetic oral agent (88 % of participants).
Študija ORIGIN (Outcome Reduction with Initial Glargine INtervention) je bila multicentrična, randomizirana študija s faktorskim načrtom 2 x 2, v katero je bilo vključenih 12.537 preskušancev z velikim srčno-žilnim (CV) tveganjem, z nenormalno vrednostjo glukoze na tešče (IFG) ali okvarjeno toleranco za glukozo (IGT) (12 % preskušancev) ali s sladkorno boleznijo tipa 2, zdravljenih z ≤ 1 peroralnim antidiabetičnim zdravilom (88 % preskušancev).
Change the injection site with each injection to help prevent these skin changes.
Mesto injiciranja zamenjajte pri vsakem injiciranju, da boste pomagali preprečiti takšne kožne spremembe.
If not, get a new pen.
Če ni, vzemite nov injekcijski peresnik.
Each pen contains 3 mL of solution for injection, equivalent to 300 units.
En injekcijski peresnik vsebuje 3 ml raztopine za injiciranje, kar ustreza 300 enotam.
Combination of LUSDUNA with pioglitazone
Kombinacija zdravila LUSDUNA in pioglitazona
You should change injection site with each injection following the advice of your doctor.
Mesto injiciranja morate ob vsakem injiciranju menjati, kot vam je naročil zdravnik.
LUSDUNA is a biosimilar medicinal product.
Zdravilo LUSDUNA je podobno biološko zdravilo.
This pen works with most kinds and sizes of pen needles such as those manufactured by Becton, Dickinson & Company and Ypsomed.
S tem injekcijskim peresnikom je mogo e uporabiti ve ino vrst in velikosti igel za injekcijske peresnike, kot so na primer igle, ki jih izdelujeta Becton, Dickinson & Company ter Ypsomed.