natgillin/translations-raw huggingface dataset:
For males and females • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
• preobčutljivost na učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1.
In women undergoing fertility treatment there may be a slightly higher chance of a miscarriage.
Pri ženskah, ki se zdravijo zaradi neplodnosti, lahko obstaja nekoliko povečana verjetnost spontanega splava.
What Fertavid looks like and contents of the pack
Izgled zdravila Fertavid in vsebina pakiranja
Fertavid cartridges are not designed to allow any other drug to be mixed in the cartridges.
Vložki Fertavid niso namenjeni za mešanje katerega koli drugega zdravila v vložku.
In more severe cases symptoms may include enlargement of the ovaries, accumulation of fluid in the abdomen and/or chest (which may cause sudden weight gain due to fluid buildup) and the occurrence of blood clots in the circulation.
V hujših primerih lahko pride do povečanja jajčnikov, nabiranja tekočine v trebuhu in/ali v prsnem košu (ki lahko povzroči nenadno povečanje telesne mase zaradi zastajanja tekočine) in pojava krvnih strdkov v obtoku.
When ultrasound assessment indicates the presence of at least three follicles of 16-20 mm, and there is evidence of a good oestradiol response (plasma levels of about 300-400 picograms/mL (1,000-1,300 pmol/L) for each follicle with a diameter greater than 18 mm), the final phase of maturation of the follicles is induced by administration of hCG. Oocyte retrieval is performed 34-35 hours later.
Če ultrazvočna preiskava pokaže najmanj tri prisotne folikle s premerom 16 do 20 mm, in če se tudi vrednosti estradiola ustrezno povečajo (plazemske koncentracije približno 300 do 400 pikogramov/ml (1.000 do 1.300 pmol/l) za vsak folikel s premerom večjim od 18 mm), sprožite končno fazo zorenja folikla s hCG. Oocite odvzamite 34 do 35 ur pozneje.
If there is no ovarian response, the daily dose is then gradually increased until follicle growth and/or plasma oestradiol levels indicate an adequate pharmacodynamic response.
Če ni odziva jajčnikov, dnevni odmerek počasi povečujte, dokler rast folikla in/ali plazemske koncentracije estradiola ne pokažejo zadostnega farmakodinamičnega odziva.
If you inject yourself with Fertavid, follow the instructions for use in the next section, to give Fertavid properly and with minimal discomfort.
Če si boste sami injicirali zdravilo Fertavid, upoštevajte navodila za uporabo, ki so podana v naslednjem poglavju, da si boste zdravilo Fertavid dali pravilno in z najmanj neugodja.
In that case hCG should be withheld and pregnancy should be avoided to prevent multiple gestations.
V tem primeru je treba zdravljenje s hCG opustiti in poskrbeti, da ženska ne zanosi, da ne pride do večplodne nosečnosti.
Pack of 1, 5 or 10 vials.
Pakiranja po 1, 5 ali 10 vial.
The dosage should, therefore, be adjusted individually depending on the ovarian response.
Zato mora biti odmerjanje individualno, odvisno od odziva jajčnikov.
It is unlikely that Fertavid is passed into breast milk.
Malo verjetno je, da bi zdravilo Fertavid prehajalo v materino mleko.
• Controlled ovarian hyperstimulation to induce the development of multiple follicles in medically assisted reproduction programs [e.g. in vitro fertilisation/embryo transfer (IVF/ET), gamete intra-fallopian transfer (GIFT) and intracytoplasmic sperm injection (ICSI)].
• nadzorovana hiperstimulacija jajčnikov, da se sproži razvoj multiplih foliklov pri programih oploditve z biomedicinsko pomočjo [npr. zunajtelesna oploditev/prenos zarodka (IVF/ET), prenos gamete v jajcevod (GIFT) ter intracitoplazemske injekcije sperme (ICSI)].
If you use more Fertavid than you should
Če ste uporabili večji odmerek zdravila Fertavid, kot bi smeli
The starting dose is maintained for at least seven days.
Začetni odmerek mora ženska prejemati najmanj sedem dni.
Step 2 - The injection site
Drugi korak - mesto injiciranja
Increased FSH blood levels are a sign of damage to the testicles.
Zvišane vrednosti FSH v krvi so znak okvare mod.
Twisting of the ovary could cause the blood flow to the ovary to be cut off.
Zasukanje jajčnika lahko povzroči prekinitev dotoka krvi v jajčnik.
Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, section 4.2.)
Predpisovanje in izdaja zdravila je le na recept s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
It is unlikely that follitropin beta is excreted in human milk due to its high molecular weight.
Izločanje folitropina beta v materino mleko je malo verjetno zaradi njegove velike molekulske mase.
The first injection with Fertavid should be performed under direct medical supervision.
Prvo injekcijo zdravila Fertavid morajo bolniki prejeti pod neposrednim zdravniškim nadzorom.
Intravascular thrombosis, which may originate in venous or arterial vessels, can result in reduced blood flow to vital organs or the extremities.
Tromboza v žilah (bodisi venskih ali arterijskih) lahko zmanjša dotok krvi v življenjsko pomembne organe ali v okončine.
Do not mix Fertavid with any other medicines.
Zdravila Fertavid ne smete mešati z drugimi zdravili.
Place a needle on a syringe and pierce the needle through the rubber stopper of the vial (a).
Na brizgo namestite iglo in z njo prebodite gumijasto zaporko na viali (a).
Table 2: Results of study 37,609 (randomized, group comparative clinical study comparing safety and efficacy of follitropin beta with urinary FSH in ovulation induction).
Preglednica 2: Izsledki Študije 37.609 (randomizirana primerjalna klinična študija v kateri so varnost in učinkovitost zdravila Fertavid primerjali z urinskim FSH pri indukciji ovulacije).
These side effects are not considered to be related to the use of Fertavid, but to Assisted Reproductive Technology (ART) or subsequent pregnancy.
Ti neželeni učinki ne veljajo za z zdravilom Fertavid povezane neželene učinke, temveč za povezane s postopki oploditve z biomedicinsko pomočjo ali s poznejšo nosečnostjo.
Clinical signs and symptoms of severe OHSS are large ovarian cysts, acute abdominal pain, ascites, pleural effusion, hydrothorax, dyspnoea, oliguria, haematological abnormalities and weight gain.
Klinični znaki in simptomi hudega OHSS so velike ciste na jajčnikih, akutna bolečina v trebuhu, ascites, plevralni izliv, hidrotoraks, dispneja, oligurija, hematološke nepravilnosti in povečanje telesne mase.
Concomitant use of Fertavid and clomifene citrate may enhance the follicular response.
Sočasna uporaba zdravila Fertavid in klomifenijevega citrata lahko poveča odziv foliklov.
You should vary the injection site a little with each injection.
Za vsako naslednjo injekcijo malo spremenite mesto vboda.
For patient convenience, Fertavid may be stored at or below 25ºC by the patient for a single period of not more than 3 months.
Zaradi lažje uporabe lahko bolnik zdravilo Fertavid shranjuje pri temperaturi do 25 ºC, vendar ne več kot 3 mesece.
This serious medical condition is called ovarian hyperstimulation syndrome (OHSS).
To resno stanje imenujemo sindrom hiperstimulacije jajčnikov (OHSS).
In rare instances, venous or arterial thromboembolism may occur in association with OHSS.
V redkih primerih se v povezavi z OHSS lahko pojavi venska ali arterijska trombembolija.
Table 1: Results of study 37,608 (randomized, group comparative clinical study comparing safety and efficacy of follitropin beta with urinary FSH in controlled ovarian stimulation).
Preglednica 1: Izsledki Študije 37.608 (randomizirana primerjalna klinična študija v kateri so varnost in učinkovitost zdravila Fertavid primerjali z urinskim FSH pri nadzorovani stimulaciji jajčnikov).
This requires ultrasound assessment of follicular development.
To zahteva oceno razvoja foliklov z ultrazvokom.
Pull the syringe out quickly and apply pressure to the injection site with a swab containing disinfectant.
Injekcijsko iglo hitro izvlecite in na mesto vboda pritisnite tampon, prepojen z razkužilom.
Before starting to use this medicine, tell your doctor if you:
Preden začnete uporabljati to zdravilo, morate zdravnika obvestiti:
Due to the relatively long elimination half-life, repeated administration of the same dose will lead to plasma concentrations of FSH that are approximately 1.5-2.5 times higher than after single dose administration.
Zaradi relativno dolgega razpolovnega časa izločanja vodi ponovno dajanje enakega odmerka do plazemskih koncentracij FSH, ki so približno 1,5- do 2,5-krat večje od koncentracij po enkratnem odmerku.
Due to the relatively long elimination halflife, repeated administration of the same dose will lead to plasma concentrations of FSH that are approximately 1.5-2.5 times higher than after single dose administration.
Zaradi relativno dolgega razpolovnega časa izločanja vodi ponovno dajanje enakega odmerka do plazemskih koncentracij FSH, ki so približno 1,5 do 2,5-krat večje od koncentracij po enkratnem odmerku.
If there is no ovarian response, the daily dose will then be gradually increased until follicle growth and/or plasma oestradiol levels indicate a proper response.
Če ne bo nobenega odziva jajčnikov, vam bo zdravnik postopoma povečeval dnevni odmerek, dokler rast folikla in/ali plazemska koncentracija estradiola ne bosta pokazali primernega odziva.
Step 1 - Preparing the syringe
Prvi korak - priprava brizge
Fertavid is used to treat infertility in any of the following situations:
Zdravilo Fertavid uporabljamo za zdravljenje neplodnosti v katerem koli od naslednjih primerov:
It is available in packs of 1, 5 or 10 vials.
Na voljo je v steklenih vialah, pakiranih po 1, 5 ali 10 vial.
In women who do not ovulate and do not respond to treatment with clomifene citrate, Fertavid can be used to cause ovulation.
Pri ženskah, ki nimajo ovulacije in pri katerih je bilo zdravljenje s klomifenijevim citratom neuspešno, uporabljamo zdravilo Fertavid za sprožitev ovulacije.
If you are breast-feeding, tell your doctor before using Fertavid.
Če dojite, morate to povedati zdravniku, preden začnete uporabljati zdravilo Fertavid.
This dose is continued for at least seven days.
Prejemali ga boste najmanj sedem dni.
Follow current clinical practice for reducing the risk of OHSS during Assisted Reproductive Technology (ART).
Za zmanjšanje tveganja za nastanek OHSS med postopkom oploditve z biomedicinsko pomočjo (ART) je treba slediti trenutni klinični praksi.
• Malformations of the reproductive organs incompatible with pregnancy.
• malformacije spolnih organov, ki preprečujejo nosečnost,
Fertavid can be given either alone, or, to prevent premature luteinisation, in combination with a GnRH agonist or antagonist.
Zdravilo Fertavid lahko dajete kot monoterapijo ali v kombinaciji z agonistom ali antagonistom GnRH za preprečitev prezgodnje luteinizacije.
Fertavid may affect milk production.
Zdravilo Fertavid lahko vpliva na nastajanje materinega mleka.
If you inject yourself with Fertavid, follow the instructions carefully to give Fertavid properly and with minimal discomfort.
Če si boste sami injicirali zdravilo Fertavid, upoštevajte navodila, da si boste zdravilo Fertavid dali pravilno in z najmanj neugodja.
In males Fertavid is used in the treatment of deficient spermatogenesis due to hypogonadotrophic hypogonadism.
Pri moških uporabljamo zdravilo Fertavid za zdravljenje zmanjšane spermatogeneze zaradi hipogonadotropnega hipogonadizma.
Medical conditions that contraindicate pregnancy should also be evaluated before starting treatment with Fertavid.
Pred začetkom zdravljenja z zdravilom Fertavid je treba oceniti tudi bolezenska stanja, pri katerih je nosečnost kontraindicirana.
Fertavid solution for injection comes in a glass vial.
Raztopina za injiciranje Fertavid je v stekleni viali.
Local reactions at the site of injection include: bruising, pain, redness, swelling and itching 3.
Med lokalne reakcije na mestu injiciranja sodijo: modrice, bolečine, pordelost, otekanje in srbenje.
The very first injection of Fertavid should only be given in the presence of a doctor or nurse.
Prvo injekcijo zdravila Fertavid smete prejeti le pod nadzorom zdravnika ali medicinske sestre.
Step 7 - Removing the syringe
Sedmi korak - odstranjevanje igle
Using the pen injector, injection of Fertavid can be carried out by the patient, provided that proper instructions are given by the physician.
Z uporabo peresnika lahko zdravilo Fertavid injicira bolnik, če od zdravnika dobi ustrezna navodila.
How to use Fertavid
Kako uporabljati zdravilo Fertavid
• Tumours of the ovary, breast, uterus, testis, pituitary or hypothalamus.
• tumorji jajčnikov, dojk, maternice, testisov, hipofize ali hipotalamusa,
Multiple Pregnancy or birth defects
Večplodna nosečnost ali prirojene napake
There are great inter- and intra-individual variations in the response of the ovaries to exogenous gonadotrophins.
Ker obstajajo velike inter- in intra- individualne razlike v odzivu jajčnikov na eksogene gonadotropine, ni mogoče določiti enotne sheme odmerjanja.
In addition, before starting to use this medicine, tell your doctor if you:
Poleg tega morate pred začetkom uporabe tega zdravila zdravnika obvestiti:
• blood vessel problems (thrombophlebitis)
• težave s krvnimi žilami (tromboflebitis),
• have uncontrolled pituitary gland or hypothalamic problems
• če imate neobvladane težave z žlezo ščitnico ali hipotalamusom,
The solution for injection contains the active substance follitropin beta, produced by genetic engineering of a Chinese hamster ovary (CHO) cell line.
Raztopina za injiciranje vsebuje učinkovino folitropin beta, pridobljeno s pomočjo genetskega inženiringa z uporabo ovarijskih celic kitajskega hrčka (Chinese hamster ovary, CHO).
Store at 2°C - 8°C (in a refrigerator).
Shranjujte med 2 °C - 8 °C (v hladilniku).
Storage by the pharmacist Store at 2°C - 8°C (in a refrigerator).
Shranjevanje v lekarni Shranjujte med 2 °C - 8 °C (v hladilniku).
OHSS causes fluid to build up suddenly in your stomach and chest areas and can cause blood clots to form.
Ta sindrom povzroči hitro kopičenje tekočine v trebuhu in prsnem košu in lahko povzroči nastanek krvnih strdkov.
Furthermore Fertavid can be used to promote multiple follicular development in medically assisted reproduction programs [e.g. in vitro fertilisation/embryo transfer (IVF/ET), gamete intrafallopian transfer (GIFT) and intracytoplasmic sperm injection (ICSI)].
Zdravilo Fertavid se uporablja tudi za pospeševanje razvoja večih foliklov pri programih oploditve z biomedicinsko pomočjo (npr. pri zunajtelesni oploditvi/prenosu zarodka (IVF/ET), prenosu gamete v jajcevod (GIFT) in pri intracitoplazemski injekciji sperme (ICSI)).
Solution for injection 1 cartridge
raztopina za injiciranje 1 vložek
Children There is no relevant use of Fertavid in children.
Otroci Pri otrocih zdravilo Fertavid nima ustrezne uporabe.
In addition, ectopic pregnancy, miscarriage and multiple gestations have been reported.
Poleg tega so poročali tudi o zunajmaternični nosečnosti, splavu in večplodnih nosečnostih.
Fertavid solution for injection contains follitropin beta, a hormone known as follicle-stimulating hormone (FSH).
Fertavid raztopina za injiciranje vsebuje folitropin beta, hormon, ki je poznan kot folikle stimulirajoči hormon (FSH).
A few taps at the injection site will stimulate tiny nerve endings and help reduce discomfort when the needle goes in. Wash your hands and swab the injection site with disinfectant (for example chlorohexidine 0.5%) to remove any surface bacteria.
Umijte si roke in mesto vboda obrišite z razkužilom (na primer z 0,5-odstotnim klorheksidinom), da odstranite bakterije s površine kože.
The daily dose is then maintained until pre-ovulatory conditions are reached.
Takšen odmerek nato vzdržujte, dokler ne ustvarite predovulacijskih pogojev.
Dosage in women
Odmerjanje pri ženskah
• blockage in your lungs (pulmonary embolus)
• zaporo pljučnih žil (pljučno embolijo),
After intramuscular administration of Fertavid, the maximum FSH concentrations are higher and reached earlier in men as compared to women.
Po intramuskularnem dajanju se pri moških maksimalne koncentracije FSH pojavijo hitreje, njihova vrednost pa je večja kot pri ženskah.
If you forget a dose do not use a double dose to make up for a missed dose.
Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
To monitor the risk of OHSS, ultrasonographic assessments of follicular development should be performed prior to treatment and at regular intervals during treatment; the concurrent determination of serum oestradiol levels may also be useful.
Za spremljanje tveganja za OHSS je treba razvoj foliklov ocenjevati z ultrazvočnimi preiskavami pred zdravljenjem in v rednih presledkih med zdravljenjem.
• have ovarian cysts or enlarged ovaries not caused by polycystic ovarian syndrome (PCOS)
• če imate ciste na jajčnikih ali povečane jajčnike, ki niso posledica sindroma policističnih jajčnikov (PCOS),
Dosage in men
Odmerjanje pri moških
The solution for injection contains the active substance follitropin beta, produced by genetic engineering of a Chinese hamster ovary (CHO) cell line, in a concentration of 833 IU/mL aqueous solution.
Raztopina za injiciranje vsebuje učinkovino folitropin beta, pridobljeno s pomočjo genetskega inženiringa z uporabo ovarijskih celic kitajskega hrčka (Chinese hamster ovary, CHO), v koncentraciji 833 i.e./ml vodne raztopine.
• have ever had ovarian hyperstimulation syndrome OHSS
• če ste kdaj imeli sindrom hiperstimulacije jajčnikov (OHSS),
OHSS is a medical event distinct from uncomplicated ovarian enlargement.
Sindrom hiperstimulacije jajčnikov (Ovarian Hyperstimulation Syndrome - OHSS) OHSS je medicinski zaplet, ki se razlikuje od nezapletenega povečanja jajčnikov.
Clinical signs and symptoms of mild and moderate OHSS are abdominal pain, nausea, diarrhoea, mild to moderate enlargement of ovaries and ovarian cysts.
Klinični znaki in simptomi blagega in zmernega OHSS so bolečine v trebuhu, navzea, driska, blago do zmerno povečanje jajčnikov in ciste na jajčnikih.
The separate instructions for using the pen must be followed carefully.
Navodila za uporabo peresnika, ki so na voljo posebej, morate natančno upoštevati.
Pregnancy outside the uterus (an ectopic pregnancy), miscarriage and multiple pregnancies have also been reported.
Poročali so o zunajmaternični nosečnosti (ektopični nosečnosti), spontanih splavih in večplodnih nosečnostih.
• have malformations of the sexual organs which make a normal pregnancy impossible
• če imate razvojne nepravilnosti spolnih organov, ki preprečujejo normalno nosečnost,
Subcutaneous injection of Fertavid may be carried out by patient or partner, provided that proper instructions are given by the physician.
Subkutane injekcije zdravila Fertavid si lahko dajejo bolniki sami, ali jim jih dajejo njihovi partnerji, če jih zdravnik pred tem ustrezno pouči.
What Fertavid contains
Kaj vsebuje zdravilo Fertavid
Transient liver function test abnormalities suggestive of hepatic dysfunction with or without morphologic changes on liver biopsy have also been reported in association with OHSS.
V povezavi z OHSS so poročali tudi o prehodnih nenormalnih rezultatih preiskav delovanja jeter, ki so nakazovale moteno delovanje jeter, in sicer s spremljajočimi morfološkimi spremembami na biopsiji jeter ali brez.
When using a GnRH agonist, a higher total treatment dose of Fertavid may be required to achieve an adequate follicular response.
Pri uporabi agonista GnRh bo morda potreben večji odmerek zdravila Fertavid za ustrezen folikularni odziv.
In rare instances, thromboembolism has been associated with follitropin beta/hCG therapy as with other gonadotrophins.
Tako kot zdravljenje z drugimi gonadotropini je bilo tudi zdravljenje s folitropinom beta/hCG v redkih primerih povezano s tromboembolizmom.
• Each cartridge contains the active substance follitropin beta, a hormone known as folliclestimulating hormone (FSH) in a strength of 833 IU/mL aqueous solution.
• En vložek vsebuje učinkovino folitropin beta, hormon, ki je poznan pod imenom folikle stimulirajoči hormon (FSH), z jakostjo 833 i.e./ml vodne raztopine.
Ovarian Torsion
Torzija jajčnikov
Spontaneous Abortion
Spontani splav
• have ovaries that do not work because of a condition called primary ovarian failure
• če vaši jajčniki ne delujejo zaradi bolezni, ki ji pravimo primarna odpoved jajčnikov,
It is available in packs of 1 cartridge.
Na voljo je v steklenih vložkih, pakiranih po 1 vložek.
This is produced by recombinant DNA technology, using a Chinese hamster ovary cell line transfected with the human FSH subunit genes.
Pri tem uporabljajo linijo ovarijskih celic kitajskega hrčka, ki jih transfekcirajo z geni humanih podenot FSH.
These are considered to be related to ART or subsequent pregnancy.
Za te velja, da so povezani s postopkom oploditve z biomedicinsko pomočjo ali s posledično nosečnostjo.
If follitropin beta would be excreted in human milk, it would be degraded in the gastrointestinal tract of the child. Follitropin beta may affect milk production.
Če bi se folitropin beta izločal v materino mleko, bi se v prebavilih otroka razgradil.
0.5 mL of solution in 3 mL vial (type I glass) with stopper (chlorobutyl rubber).
0,5 ml raztopine v 3 ml viali (steklo tipa I) z zaporko (iz klorobutilne gume).
Store at or below 25ºC (at room temperature) for a single period of not more than 3 months.
Shranjujte pri temperaturi do 25 ºC (pri sobni temperaturi), vendar ne več kot 3 mesece.
The primary amino acid sequence is identical to that of natural human FSH.
Primarno aminokislinsko zaporedje je enako tistemu v naravnem človeškem FSH, obstajajo pa majhne razlike v strukturi ogljikovodikove verige.
The instructions for using the pen must be followed carefully.
Natančno upoštevajte navodila za uporabo peresnika.
The concurrent determination of serum oestradiol levels may also be useful.
Koristi lahko tudi sočasno določanje koncentracije estradiola v serumu.
Vascular Complications
Žilni zapleti
Do not mix any other drug into the cartridges.
V vložku ne smete mešati nobenega drugega zdravila.
1,025 IU recombinant FSH activity/1.230 mL Net content 900 IU
1.025 i.e. aktivnosti rekombinantnega FSH/1,230 ml Neto vsebina 900 i.e.
Uncommon side effects (may affect up to 1 in 100 people): - Breast complaints (including tenderness) - Diarrhoea, constipation or stomach discomfort - Enlargement of the uterus - Feeling sick - Hypersensitivity reactions (such as rash, redness, hives and itching) - Ovarian cysts or enlargement of the ovaries - Ovarian torsion (twisting of the ovaries) - Vaginal bleeding
Občasni neželeni učinki (pojavijo se lahko pri največ 1 od 100 bolnic): - težave z dojkami (vključno z bolečnostjo) - driska, zaprtje ali nelagodje v želodcu - povečanje maternice - občutek slabosti - preobčutljivostne reakcije (na primer izpuščaj, pordelost, koprivnica in srbenje) - ciste jajčnikov ali povečanje jajčnikov - torzija jajčnikov (zasuk jajčnikov) - krvavitve iz nožnice
Fertavid treatment is then stopped and ovulation will be induced by giving human chorionic gonadotrophin (hCG).
Takrat zdravljenje z zdravilom Fertavid prekinemo in sprožimo ovulacijo z dajanjem humanega horionskega gonadotropina (hCG).
• Undiagnosed vaginal bleeding.
• nepojasnjena krvavitev iz nožnice,
Any unused solution should be discarded.
Morebitno neporabljeno raztopino zavrzite.
Fertavid solution for injection in cartridges has been developed for use in a pen injector called Puregon Pen and should be administered subcutaneously.
Fertavid raztopina za injiciranje v vložkih je bila razvita za uporabo v peresniku Puregon Pen in se uporablja subkutano.
Adherence to the recommended Fertavid dose and treatment regimen and careful monitoring of ovarian response is important to reduce the risk of OHSS.
Za zmanjšanje tveganja za nastanek OHSS je pomembno upoštevanje priporočenega odmerka zdravila Fertavid in režima zdravljenja, ter skrbno spremljanje odziva jajčnikov pri ženski.
• have a tumour of the ovary, breast, uterus, testis or brain (pituitary gland or hypothalamus)
• če imate tumor jajčnikov, dojk, maternice, mod ali možganov (hipofize ali hipotalamusa),