natgillin/translations-raw huggingface dataset:
Insufficient numbers of older patients have been evaluated in clinical studies to determine whether they respond differently than younger patients.
V kliničnih študijah niso preučili zadostnega števila starejših bolnikov, da bi lahko ugotovili, ali se ti odzivajo drugače od mlajših bolnikov.
• Once you start taking Stocrin, look out for:
• Ko začnete jemati zdravilo Stocrin, bodite pozorni na:
It is important to take precautions to avoid infecting other people through sexual contact or blood transfer.
Pomembno je, da ste previdni in se izogibate okužbi drugih ljudi s spolnim stikom ali prenosom krvi.
• It is recommended that the tablet be swallowed whole with water.
• Priporočamo, da tableto pogoltnete celo, z vodo.
Stocrin with food and drink
Zdravilo Stocrin skupaj s hrano in pijačo
• if you are allergic to efavirenz or any of the other ingredients of this medicine (listed in section 6).
• če ste alergični na efavirenz ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
ATC code: J05A G03
Oznaka ATC: J05A G03
rare photoallergic dermatitis
redki fotoalergijski dermatitis
Do not take Stocrin:
Ne jemljite zdravila Stocrin:
Do not use this medicine after the expiry date which is stated on the bottle and on the carton after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na plastenki in na škatli poleg oznake "EXP".
If you have severe liver disease, do not take Stocrin (see Section 2, Do not take Stocrin).
Če imate hudo bolezen jeter, ne jemljite zdravila Stocrin (glejte poglavje 2, Ne jemljite zdravila Stocrin).
Although not studied, a similar decrease in voxilaprevir exposure is anticipated.
Čeprav ni bilo preučevano, se pričakuje podobno zmanjšanje v izpostavljenosti voksilaprevirju.
In controlled trials the frequency of specific serious psychiatric events were:
V nadzorovanih preskušanjih je bila pogostnost določenih resnih psihiatričnih neželenih učinkov sledeča:
Skin and subcutaneous tissue disorders very common rash (11.6 %)*
Bolezni kože in podkožja zelo pogosti izpuščaj (11,6 %)*
For bottles: 3 years
Za plastenke: 3 leta
Efavirenz is highly bound (approximately 99.5 - 99.75 %) to human plasma proteins, predominantly albumin.
Efavirenz se močno veže (približno 99,5 - 99,75 %) na človeške plazemske beljakovine, predvsem na albumin.
• The dose for Stocrin may need to be increased or decreased if you are also taking certain medicines (see Other medicines and Stocrin).
• Odmerek zdravila Stocrin bo morda treba povečati ali zmanjšati v primeru, da jemljete še kakšna druga zdravila (glejte Druga zdravila in zdravilo Stocrin).
• if your doctor has told you that you have high or low levels of electrolytes such as potassium or magnesium in your blood.
• če vam je zdravnik povedal, da imate visok ali nizek nivo elektrolitov, kot sta kalij ali magnezij, v krvi.
• if you have severe liver disease.
• če imate hudo bolezen jeter.
What Stocrin is and what it is used for
Kaj je zdravilo Stocrin in za kaj ga uporabljamo
Your doctor has prescribed Stocrin for you because you have HIV infection.
Zdravnik vam je predpisal zdravilo Stocrin, ker ste okuženi z virusom HIV.
• Stocrin oral solution may be taken with or without food.
• Peroralno raztopino Stocrin lahko vzamete s hrano ali brez nje.
• Before giving the dose of the oral solution make sure that the patient is sitting or standing upright.
• Pred dajanjem odmerka peroralne raztopine se prepričajte, da je bolnik v sedečem ali stoječem položaju.
Effects on drug levels Mean percent change in AUC, Cmax, Cmin with confidence intervals if available (mechanism)
Učinki na koncentracije učinkovin Srednja sprememba AUC, Cmax, Cmin z intervali zaupanja, če so na voljo (mehanizem)
When treating HIV infection, it is not always possible to tell whether some of the unwanted effects are caused by Stocrin or by other medicines that you are taking at the same time, or by the HIV disease itself.
Pri zdravljenju okužbe s HIV je včasih težko reči, ali se nekateri neželeni učinki pojavijo zaradi zdravila Stocrin, drugih zdravil, ki jih jemljete sočasno, ali zaradi bolezni HIV same.
- if you have a heart disorder, such as abnormal electrical signal called prolongation of the QT interval.
če imate motnjo v delovanju srca, kot je nenormalen električni signal, ki se imenuje podaljšanje intervala QT.
The durability of the response was similar to that seen in adult patients.
Trajanje odziva je bilo podobno tistemu, ki so ga opazili pri odraslih bolnikih.
S.E.M., standard error of the mean.
S.N.P., standardna napaka povprečja.
Expected: ↓ Voxilaprevir
Pričakovano: ↓ voksilaprevir
If you are pregnant, you should take Stocrin only if you and your doctor decide it is clearly needed.
Če ste noseči, lahko zdravilo Stocrin jemljete le, če se z zdravnikom skupaj odločita, da je to nujno potrebno.
Do not put the syringe in a dishwasher.
Brizge ne perite v pomivalnem stroju.
Frequency is defined using the following convention: very common (≥ 1/10); common (≥ 1/100, < 1/10); uncommon (≥ 1/1,000, < 1/100); rare (≥ 1/10,000, < 1/1,000); or very rare (< 1/10,000).
Pogostnost je definirana z uporabo sledečega dogovora: zelo pogosti (≥ 1/10); pogosti (≥ 1/100, < 1/10); občasni (≥ 1/1.000, < 1/100); redki (≥ 1/10.000, < 1/1.000) ali zelo redki (< 1/10.000).
Other medicines and Stocrin
Druga zdravila in zdravilo Stocrin
- if you have a history of liver disease, including active chronic hepatitis.
če ste v preteklosti imeli bolezen jeter, vključno z aktivnim kroničnim hepatitisom.
- severe disturbances of electrolyte balance e.g. hypokalaemia or hypomagnesaemia.
- hudo motnjo elektrolitskega ravnotežja, npr. hipokaliemijo ali hipomagnezemijo.
• if you have a heart condition, such as changes in the rhythm or rate of the heart beat, a slow heart beat, or severe heart disease.
• če imate bolezen srca, kot so sprememba ritma ali hitrosti bitja srca, počasen srčni utrip ali hudo bolezen srca.
, neurosis
, nevroza
‡, suicide attempt, suicide ideation, catatonia*
‡, poskus samomora, misli na samomor, katatonija*
Table 2: Interactions between efavirenz and other medicinal products in adults
Preglednica 2: Interakcije med efavirenzem in drugimi zdravili pri odraslih
If parts of the syringe are not clean, repeat the cleaning instructions.
Če brizga ni očiščena, postopek ponovite.
- any signs of skin rash.
kateri koli znak kožnega izpuščaja.
If available, 90 % or 95 % confidence intervals are shown in parentheses.
90-odstotni ali 95-odstotni intervali zaupanja so prikazani v oklepajih, če so na voljo.
• Stocrin must be taken with other medicines that act against the HIV virus.
• Zdravilo Stocrin je treba jemati skupaj z drugimi zdravili, ki delujejo proti virusu HIV.
Similar elevations were seen in patients treated with control regimens (5 % after long-term treatment).
Podobna povišanja so opazili tudi pri bolnikih na kontrolnem režimu (5 % po dolgotrajnem zdravljenju).
Although nervous system symptoms are difficult for young children to report, they appear to be less frequent in children and were generally mild.
Čeprav majhni otroci težko poročajo o simptomih živčnega sistema, se zdi, da so le-ti pri otrocih manj pogosti in večinoma blagi.
Taking Stocrin on an empty stomach may reduce the undesirable effects.
Jemanje zdravila Stocrin na tešče lahko zmanjša neželene učinke.
Not recommended, as the exposure to both PIs is expected to be significantly decreased.
Ne priporočamo, ker lahko pričakujemo, da bi s tem pomembno zmanjšali izpostavitev obema ZP.
You must not take Stocrin with certain medicines.
Zdravila Stocrin ne smete jemati skupaj z določenimi zdravili.
Taking these medicines with Stocrin could create the potential for serious and/or life-threatening side-effects or stop Stocrin from working properly.
Jemanje teh zdravil skupaj z zdravilom Stocrin bi lahko povzročilo resne in/ali življenjsko nevarne neželene učinke ali preprečilo pravilno delovanje zdravila Stocrin.
Therefore, efavirenz should not be given to children less than 3 years of age.
Zato se efavirenza ne sme dati otrokom, mlajšim od 3 let.
Study Number/ Treatment Regimens n % (95 % C.I.
Številka študije/ režimi zdravljenja n % (95-odstotni IZ
Remove the plunger rod from the barrel and thoroughly rinse both parts with warm running water.
Odstranite bat brizge in temeljito sperite oba dela brizge pod toplo tekočo vodo.
What you need to know before you take Stocrin
Kaj morate vedeti, preden boste vzeli zdravilo Stocrin
Adults and children aged 5 years or more
Odrasli in otroci stari 5 let ali več
Hold the bottle and the syringe firmly in one hand and with the other hand pull back the plunger slightly beyond the mark for the dose required.
Z eno roko trdno primite plastenko in brizgo ter z drugo roko potegnite bat brizge malo čez oznako za želeni odmerek.
As a result, the amounts of Stocrin or other medicines in your blood may be affected.
Posledično se lahko spremeni količina zdravila Stocrin ali drugih zdravil v krvi.
Repeat until there are no bubbles in the syringe.
To ponavljajte dokler so v brizgi mehurčki.
• You can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy.
• Med jemanjem tega zdravila lahko še vedno prenesete okužbo s HIV na druge, čeprav učinkovito protiretrovirusno zdravljenje to tveganje zmanjša.
- if you have a history of mental illness, including depression, or of substance or alcohol abuse.
če ste v preteklosti imeli duševno bolezen, vključno z depresijo, ali bili odvisni od substanc ali alkohola.
Efavirenz oral solution may be taken with or without food (see section 5.2).
Efavirenz peroralna raztopina se lahko jemlje s hrano ali brez nje (glejte poglavje 5.2).
The starting dose of efavirenz was the equivalent of a 600 mg dose (adjusted from calculated body size based on weight).
Začetni odmerek efavirenza je bil ekvivalenten 600 mg (prilagojen glede na izračunano velikost telesa na podlagi telesne mase).
Efavirenz is a non-competitive inhibitor of HIV-1 reverse transcriptase (RT) and does not significantly inhibit HIV-2 RT or cellular DNA polymerases (, ,  or ).
Efavirenz je nekompetitivni zaviralec reverzne transkriptaze (RT) HIV-1 in ne zavira pomembno RT HIV-2 ali celičnih polimeraz DNA (, ,  ali ).
C.I., confidence interval.
IZ, interval zaupanja d
Very common (affects more than 1 user in 10) - skin rash
Zelo pogosti (pojavijo se pri več kot 1 od 10 bolnikov) - kožni izpuščaj
• The dose for children weighing less than 40 kg is calculated by body weight and is taken once daily as shown below:
• Odmerek za otroke, ki tehtajo manj kot 40 kg, je izračunan glede na telesno maso in se ga vzame enkrat na dan, kakor je prikazano v naslednji tabeli:
Allow the parts to dry completely prior to reassembly.
Oba dela brizge osušite, preden ju ponovno združite.
It is recommended that STOCRIN be taken on an empty stomach.
Priporočamo, da se zdravilo STOCRIN jemlje na prazen želodec.
Efavirenz has a relatively long terminal half-life of at least 52 hours after single doses and 40 - 55 hours after multiple doses.
Efavirenz ima relativno dolg končni razpolovni čas: vsaj 52 ur po enkratnem odmerku in 40 do 55 ur po večkratnih odmerkih.
Lopinavir concentrations:
Koncentracije lopinavirja:
If Stocrin is started because your current treatment has not prevented the virus from multiplying, another medicine you have not taken before must be started at the same time.
Če boste začeli z jemanjem zdravila Stocrin zato, ker dosedanji način zdravljenja ni preprečil razmnoževanja virusa, morate hkrati začeti jemati tudi drugo protivirusno zdravilo, ki ga do sedaj še niste jemali.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze-galaktoze ne smejo jemati tega zdravila.
Evidence exists indicating that efavirenz may have altered pharmacokinetics in very young children.
Obstajajo dokazi, ki kažejo na spremenjeno farmakokinetiko efavirenza pri zelo malih otrocih.
Five of these NNRTI-resistant isolates were found to have K103N or a valine-to-isoleucine substitution at position 108 (V108I) in RT. Three of the efavirenz treatment failure isolates tested remained sensitive to efavirenz in cell culture and were also sensitive to nevirapine and delavirdine.
Pri petih od teh na NNRTI-je rezistentnih izolatov so našli substitucijo K103N ali substitucijo valin-v-izolevcin na položaju 108 (V108I) na RT. Trije od teh testiranih izolatov iz neuspešnega zdravljenja z efavirenzem so ostali občutljivi na efavirenz v celični kulturi in so bili občutljivi tudi na nevirapin in delavirdin.
In addition, your doctor may prescribe a higher dose of Stocrin.
Poleg tega vam bo zdravnik morda predpisal večji odmerek zdravila Stocrin.
It contains: lactose monohydrate.
Zdravilo vsebuje laktozo monohidrat.
In the long-term study (006), 1 % of patients in each treatment arm discontinued because of liver or biliary system disorders.
V dolgoročni študiji (006) je 1 % bolnikov v vsakem kraku prekinilo zdravljenje zaradi motenj v delovanju jeter, žolčnika ali žolčevodov.
If air bubbles appear in the syringe, keep the bottle upside down and slowly push in the plunger and pull it back again.
Če se v brizgi pojavijo zračni mehurčki, obdržite plastenko obrnjeno narobe in počasi potisnite bat brizge gor in nazaj dol.
Patients with a history of psychiatric disorders appear to be at greater risk of these serious psychiatric adverse reactions with frequencies of each of the above events ranging from 0.3 % for manic reactions to 2.0 % for both severe depression and suicidal ideation.
Kaže, da obstaja pri bolnikih, ki so v preteklosti že imeli psihiatrične motnje, večje tveganje za te resne psihiatrične neželene učinke, pri čemer pogostnost vsakega od zgoraj navedenih neželenih učinkov znaša od 0,3 % za manične reakcije do 2,0 % za hudo obliko depresije in za misli na samomor.
13 to < 15 15 to < 20 20 to < 25 25 to < 32.5 32.5 to < 40  Stocrin 50 mg, 200 mg and 600 mg film-coated tablets are available.
13 do < 15 15 do < 20 20 do < 25 25 do < 32,5 32,5 do < 40 * Na voljo so Stocrin 50 mg, 200 mg in 600 mg filmsko obložene tablete.
Cmax: ↓ 24 % (↓ 18 to ↓ 30) These changes are not considered clinically significant.
Cmax: ↓ 24 % (↓ 18 do ↓ 30) Ti spremembi se ne smatrata za klinično pomembni.
• On first use, the bottle adapter must be fitted into the neck of the bottle.
• Pri prvi uporabi mora biti nastavek nameščen na vrat plastenke.
The free concentration of efavirenz required for 90 to 95 % inhibition of wild type or zidovudine-resistant laboratory and clinical isolates in vitro ranged from 0.46 to 6.8 nM in lymphoblastoid cell lines, peripheral blood mononuclear cells (PBMCs) and macrophage/monocyte cultures.
Koncentracija prostega efavirenza, potrebna za 90 % do 95 % in vitro inhibicijo laboratorijskih in kliničnih izolatov divjega tipa ali tistih, ki so rezistentni na zidovudin, je bila v območju od 0,46 do 6,8 nM, in sicer v limfoblastoidnih celičnih linijah, perifernih krvnih enojedrnih celicah (PBMC) in v kulturah makrofagov/monocitov.
- signs of dizziness, difficulty sleeping, drowsiness, difficulty concentrating or abnormal dreaming.
znake omotice, oteženo spanje, zaspanost, težave s koncentracijo ali nenormalne sanje.
cells/mm 3 (S.E.M.
celic/mm 3 (S.N.P.
Diarrhoea occurred in children who took Stocrin oral solution and nelfinavir in combination with other antiretroviral medicines.
Driska se je pojavila pri otrocih, ki so jemali peroralno raztopino Stocrin in nelfinavir v kombinaciji z drugimi protiretrovirusnimi zdravili.
In a single-dose study, half life was doubled in the single patient with severe hepatic impairment (Child-Pugh Class C), indicating a potential for a much greater degree of accumulation.
V študiji z enkratnim odmerjanjem je bil pri edinem bolniku s hudo jetrno okvaro (razred C po Child Pugh-u) razpolovni čas dvakrat daljši, kar kaže na možnost veliko večje akumulacije.
The net effect of co-administration is not clear.
Skupni učinek sočasne uporabe ni jasen.
If you forget to take Stocrin
Če ste pozabili vzeti zdravilo Stocrin
Although cross-resistance of efavirenz with PIs has not been documented, there are at present insufficient data on the efficacy of subsequent use of PI based combination therapy after failure of regimens containing STOCRIN.
Čeprav navzkrižna rezistenca efavirenza z ZP ni dokumentirana, trenutno nimamo dovolj podatkov o učinkovitosti uporabe kombiniranega zdravljenja, ki vključuje ZP, po neuspelem zdravljenju z režimom, ki je vključeval tudi zdravilo STOCRIN.
The dose of Stocrin oral solution in mg is not the same as for Stocrin film-coated tablets.
Odmerek peroralne raztopine Stocrin v mg ni enak kot odmerek pri filmsko obloženih tabletah Stocrin.
What Stocrin is and what it is used for What you need to know before you take Stocrin How to take Stocrin
Kaj je zdravilo Stocrin in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Stocrin Kako jemati zdravilo Stocrin Možni neželeni učinki
The pharmacokinetics of efavirenz in paediatric patients were similar to adults.
Farmakokinetika efavirenza pri pediatričnih bolnikih je bila podobna kot pri odraslih.
Stocrin taken in combination with other antiretroviral medicines reduces the amount of the virus in the blood.
Zdravilo Stocrin v kombinaciji z drugimi protiretrovirusnimi zdravili zmanjšuje količino virusa v krvi.
In the subset of 6 children aged 3 - 5 who were compliant with their drug regimen, the mean AUC was 147 M·h, which was 23 % lower than expected.
V podskupini 6 otrok, starih 3 - 5 let, ki so zdravilo dobivali v skladu z navodili, je bil povprečni AUC 147 M∙h, kar je bilo 23 % manj od pričakovanega.
In HIV-1 infected patients (n = 9) who received efavirenz 200 to 600 mg once daily for at least one month, cerebrospinal fluid concentrations ranged from 0.26 to 1.19 % (mean 0.69 %) of the corresponding plasma concentration.
Pri bolnikih, okuženih s HIV-1 (n = 9), ki so vsaj en mesec dobivali 200 do 600 mg efavirenza enkrat na dan, je bila njegova koncentracija v cerebrospinalni tekočini v območju od 0,26 do 1,19 % (povprečno 0,69 %) ustrezne plazemske koncentracije.
• Stocrin should never be used alone to treat HIV.
• Za zdravljenje HIV ne smete nikoli uporabljati zdravila Stocrin samega.
Immunosuppressants such as cyclosporine, sirolimus, or tacrolimus (medicines used to prevent organ transplant rejection): when you start or stop taking Stocrin, your doctor will closely monitor your plasma levels of the immunosuppressant and may need to adjust its dose.
Imunosupresive, kot so ciklosporin, sirolimus ali takrolimus (zdravila za preprečitev zavrnitve presajenega organa): ko boste začeli ali prenehali jemati zdravilo Stocrin, bo zdravnik skrbno nadzoroval količino imunosupresiva v plazmi in bo morda moral prilagoditi njegov odmerek.
90 % confidence intervals unless otherwise noted.
90-odstotni intervali zaupanja, razen če ni drugače navedeno 95-odstotni intervali zaupanja
Nervous system symptoms of moderate-to-severe intensity were experienced by 19 % (severe 2.0 %) of patients compared to 9 % (severe 1 %) of patients receiving control regimens.
Zmerni do hudi simptomi živčnega sistema so se pojavili pri 19 % bolnikov (hudi pri 2,0 %), v primerjavi z 9 % bolnikov (hudi pri 1 %) na kontrolnem režimu.
Interactions between efavirenz and protease inhibitors, antiretroviral agents other than protease inhibitors and other non-antiretroviral medicinal products are listed in Table 2 below (increase is indicated as “↑”, decrease as “↓”, no change as “↔”, and once every 8 or 12 hours as “q8h” or “q12h”).
Interakcije med efavirenzem in zaviralci proteaze, protiretrovirusnimi učinkovinami, ki niso zaviralci proteaze, in drugimi neprotiretrovirusnimi zdravili so navedene v preglednici 2 spodaj (povečanje je označeno z znakom "↑", zmanjšanje z "↓", brez spremembe z "↔", ter enkrat na 8 ur oz. 12 ur z oznako "q8h" oz. "q12h").
EFV, efavirenz; ZDV, zidovudine; 3TC, lamivudine; IDV, indinavir; NRTI, nucleoside reverse transcriptase inhibitor; NFV, nelfinavir.
EFV, efavirenz; ZDV, zidovudin; 3TC, lamivudin; IDV, indinavir; NRTI, zaviralec nukleozidne reverzne transkriptaze; NFV, nelfinavir.
Tests may show: - increased liver enzymes in the blood - increased triglycerides (fatty acids) in the blood
Testi lahko pokažejo: - povišane vrednosti jetrnih encimov v krvi - povišane vrednosti trigliceridov (maščobnih kislin) v krvi
In clinical controlled trials, frequently reported adverse reactions included, but were not limited to: dizziness, insomnia, somnolence, impaired concentration and abnormal dreaming.
V nadzorovanih kliničnih preizkušanjih so pogosto poročani neželeni učinki vključevali tudi (vendar ne samo): omotico, nespečnost, zaspanost, motnje koncentracije in nenormalne sanje.
Put the tip of the syringe just inside the mouth, pointing it towards the cheek.
Konico brizge postavite v usta tako, da je usmerjena proti licu.
Information regarding post-marketing surveillance These adverse reactions were identified through post-marketing surveillance; however, the frequencies were determined using data from 16 clinical trials (n=3,969).
Te neželene učinke so odkrili med spremljanjem zdravila na trgu; vendar pa so bile pogostnosti določene z uporabo podatkov iz 16 kliničnih preskušanj (n = 3.969).
The safety and efficacy of efavirenz in children below the age of 3 years or weighing less than 13 kg have not yet been established.
Varnost in učinkovitost efavirenza pri otrocih, mlajših od 3 let ali lažjih od 13 kg, še nista bili dokazani.
cells/mm (S.E.M.
celic/mm (S.N.P.
The pattern of amino acid substitutions in RT associated with resistance to efavirenz was independent of the other antiviral medicinal products used in combination with efavirenz.
Struktura aminokislinskih substitucij na RT, ki so bile povezane z rezistenco na efavirenz, ni bila odvisna od uporabe drugih protivirusnih zdravil v kombinaciji z efavirenzem.
Patients taking drugs that are known to prolong the QTc interval (proarrhythmic).
Bolniki, ki jemljejo zdravila, za katera je znano, da podaljšajo interval QTc (proaritmično delovanje).
The mean CD4 cell counts were increased by 63  34.5 cells/mm
Povprečno število CD4 celic pa se je od osnovne vrednosti povečalo za 63 ± 34,5 celic/mm
OUTER CARTON AND LABEL TEXT FOR BOTTLE PACK
BESEDILO NA ŠKATLI IN NALEPKI ZA PLASTENKO
uncommon hepatitis acute rare hepatic failure
občasni akutni hepatitis redki odpoved jeter
*lower than recommended doses, similar findings are expected with recommended doses.
*nižji od priporočenih odmerkov, podobno pričakujemo pri priporočenih odmerkih darunavir:
Hormonal contraceptive, such as birth control pills, an injected contraceptive (for example, Depo-Provera), or a contraceptive implant (for example, Implanon): you must also use a reliable barrier method of contraception (see Pregnancy, breast-feeding and fertility).
Hormonske kontraceptive, kot so kontracepcijske tablete, kontraceptivi v obliki injekcij (na primer Depo-Provera) ali kontracepcijski vsadki (na primer Implanon): uporabljati morate tudi zanesljivo mehansko obliko kontracepcije (glejte Nosečnost, dojenje in plodnost).
Reported rates of recurrent rash following a switch from nevirapine to efavirenz therapy, primarily based on retrospective cohort data from published literature, range from 13 to 18 %, comparable to the rate observed in patients treated with efavirenz in clinical studies.
Delež ponovitev izpuščaja po zamenjavi zdravljenja z nevirapinom z zdravljenjem z efavirenzem, o katerem so poročali in ki temelji na podatkih iz retrospektivnih kohortnih študij iz objavljene literature, znaša od 13 do 18 %, kar je primerljivo z deležem, ki so ga opazili pri bolnikih, ki so se z efavirenzem zdravili v kliničnih študijah.
Rash was more common in children than in adults treated with Stocrin.
Izpuščaj se je pojavljal bolj pogosto pri otrocih kakor pri odraslih, zdravljenih z zdravilom Stocrin.