natgillin/translations-raw huggingface dataset:
As all three studies were poorly documented (e.g. relevant information of diagnostic procedures, microbiology, clinical observations etc were missing) therefore the results can not be interpreted properly.
Ker so bile vse tri študije slabo dokumentirane (npr. manjkali so ustrezni podatki o diagnostičnih postopkih, mikrobiologiji, kliničnih ugotovitvah itn.), rezultatov ni možno pravilno razlagati.
2320 Hoogstraten BELGIUM
2320 Hoogstraten BELGIJA
25250 Bellpuig (Lerida) SPAIN
25250 Bellpuig (Lerida) ŠPANIJA
The uptake of medicated water is dependant on the clinical conditions of the birds.
Vnos medicirane vode je odvisen od kliničnega stanja ptic.
9140 Temse BELGIUM
9140 Temse BELGIJA
Romania INDUSTRIA ITAILIANA
Romunija INDUSTRIA ITAILIANA
One response was received after the given deadline for submission and therefore was not accepted and the CVMP performed its assessment without considering the product specific data.
En odgovor je bil prejet po postavljenem roku za predložitev, zato ni bil sprejet, CVMP pa je opravil oceno brez upoštevanja podatkov v zvezi s tem zdravilom.
Romania VMD Berendonk 74
Romunija VMD Berendonk 74
Bulgaria Biovet AD 39 Petar Rakov Str.
Bolgarija Biovet AD 39 Petar Rakov Str.
03-176 Warszawa POLAND
03-176 Warszawa POLJSKA
Medicated drinking water should be freshly prepared every 24 hours.
Vsakih 24 ur je treba pripraviti svežo medicirano pitno vodo.
This was the only study submitted in support of the O. rhinotracheale claim.
To je bila edina študija, predložena v podporo trditvi glede O. rhinotracheale.
The study was run in 2 phases, a pilot phase determining the optimal infectious dose followed by a confirmatory phase.
Študija je bila izvedena v dveh fazah, v pilotski fazi so določili optimalni infektivni odmerek, sledila pa je potrditvena faza.
s.r.o., Višňová 2/484, 140 00 Praha 4, Czech Republic
s.r.o., Višňová 2/484, 140 00 Praha 4, Češka republika
V.M.D.n.v./ s.a. Hoge Muew 900 2370 Arendonk BELGIUM
V.M.D.n.v./ s.a. Hoge Muew 900 2370 Arendonk BELGIJA
The procedure involved 179 veterinary medicinal products authorised or pending authorisation in different Member States of the European Union (see Annex I).
Postopek je zajel 179 zdravil za uporabo v veterinarski medicini, ki so že odobrena ali v postopku odobritve v državah članicah Evropske unije (glejte Dodatek I).
2600 Antwerpen BELGIUM
2600 Antwerpen BELGIJA
To ensure a correct dosage body weight should be determined as accurately as possible.
Za zagotovitev pravilnega odmerka je treba čim natančneje določiti telesno maso.
• the CVMP considered that the use of doxycycline hyclate was well established.
• CVMP je menil, da je uporaba doksiciklinijevega hiklata dobro uveljavljena.
It is recommended to prepare a concentrated pre-solution - approximately 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required.
Priporočljivo je, da se pripravi koncentrirana vnaprej pripravljena raztopina - približno 100 gramov zdravila na liter pitne vode - in se po potrebi dodatno redči do terapevtskih koncentracij.
The latest resistance rates of E. coli isolated from chickens is reported for Germany in a range of 19.3-37% (Wallmann et al, 2007)5.
Zadnji podatki o stopnjah odpornosti E. coli, izolirane iz piščancev, so iz Nemčije in so v razponu 19,3-37 % (Wallmann et al, 2007)5.
30625 Hannover GERMANY
30625 Hannover NEMČIJA
Univete SA Rua D. Jerónimo Osório, 5
Portugalska Univete SA Rua D. Jerónimo Osório, 5
Romania S.C. VIM SPECTRUM SRL 409 Sighisoarei Targu Mures ROMANIA
Romunija S.C. VIM SPECTRUM SRL 409 Sighisoarei Targu Mures ROMUNIJA
06516 CARROS FRANCE
06516 CARROS FRANCIJA
Székesfehérvár HUNGARY
Székesfehérvár MADŽARSKA
The other studies provide with indicative support for the target dose, since a subjective primary endpoint - clinical improvement - was used, and since these studies were poorly documented.
Druge študije kažejo podporo ciljnemu odmerku, ker so uporabili subjektivno primarno merilo izida - klinično izboljšanje - in ker so bile te študije slabo dokumentirane.
Budapest Ottó u. 14, Hungary
Budapest Ottó u. 14, Madžarska
Maxx Pharma OÜ Kaluri tee 5
Estonija Maxx Pharma OÜ Kaluri tee 5
ZA Le Patis 78120 Rambouillet FRANCE
ZA Le Patis 78120 Rambouillet FRANCIJA
Residue studies were mainly conducted in chickens.
Študije ostankov so bile predvsem izvedene pri piščancih.
831 02 Bratislava SLOVENIA
831 02 Bratislava SLOVAŠKA
Hungary Animal-Med Kft. 1029 Budapest
Madžarska Animal-Med Kft. 1029 Budapest
Bulgaria Farmavet OOD 40 Otec Paisij Str.
Bolgarija Farmavet OOD 40 Otec Paisij Str.
Romania CEVA PHYLAXIA VETERINARY
Romunija CEVA PHYLAXIA VETERINARY
Only the above mentioned nineteen responses that contained full dossiers developed in accordance with the Article 12(3) of Directive 2001/82/EC were considered of adequate quality for the purpose of answering to the specific issues raised.
Samo zgoraj omenjeni devetnajsti odgovori, ki so vsebovali popolno dokumentacijo, pripravljeno v skladu s členom 12(3) Direktive 2001/82/ES, so se šteli za zadostne kakovosti, da so odgovorili na posamezna postavljena vprašanja.
The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours.
Dnevna količina se doda v pitno vodo tako, da živali zaužijejo celotno zdravilo v 24 urah.
Viale Corassori 62 41100 Modena ITALY
Viale Corassori 62 41100 Modena ITALIJA
Verovskava 57 1000 Ljubljana SLOVENIA
Verovškova 57 1000 Ljubljana SLOVENIJA
The data made available indicated that the concerned veterinary medicinal products are authorised or pending authorisations via different marketing authorisation procedures (mutual recognition procedures or national procedures) and under various legal bases (full, generic and informed consent).
Predloženi podatki so kazali, da so zadevna zdravila za uporabo v veterinarski medicini odobrena ali v postopku odobritve po različnih postopkih pridobitve dovoljenja za promet z zdravilom (postopki z medsebojnim priznavanjem ali nacionalni postopki) in na različnih pravnih podlagah (popolnih, generičnih in s prostovoljnim soglasjem).
Skierniewice POLAND
Skierniewice POLJSKA
It was noted that some parts of the data submitted were identical but were submitted by different MAHs.
Ugotovljeno je bilo, da so nekateri deli predloženih podatkov enaki, vendar so jih predložili različni imetniki dovoljenj za promet z zdravilom.
The results indicated that doxycycline effectively improved the clinical performance of the chickens and reduced gradually mortality.
Rezultati so pokazali, da je doksiciklin učinkovito izboljšali klinično zmogljivost piščancev in postopoma zmanjšal smrtnost.
Obviously no attempts were made to determine the actual dose in chickens.
Jasno je, da poskusov določitve dejanskega odmerka pri piščancih ni bilo.
De Adelaar BV Hosterweg 26a 5811 Ccastenray THE
De Adelaar BV Hosterweg 26a 5811 Ccastenray NIZOZEMSKA
Treatment duration was five consecutive days in all studies.
V vseh študijah je bilo trajanje zdravljenja 5 zaporednih dni.
Hungary V.M.D.
Madžarska V.M.D.
To support the efficacy of the products concerned altogether 11 original proprietary studies were submitted by the Applicants/Marketing Authorisation Holders including 3 experimental infection studies and 8 clinical field studies.
V podporo učinkovitosti zadevnih zdravil so predlagatelji/imetniki dovoljenj za promet z zdravilom predložili enajst izvirnih lastniških študij, ki so obsegale tri študije z eksperimentalno okužbo in osem kliničnih terenskih študij.
The data packages submitted consist of bibliographic data available in the public domain and proprietary data.
Predloženi sklopi podatkov obsegajo bibliografske podatke, ki so javno dostopni, in pravno zaščitene podatke.
In some studies the residue depletion kinetics of doxycycline were not demonstrated because tissue residues were detected at one or two time points after drug withdrawal only.
V nekaterih študijah kinetika izločanja ostankov doksiciklina ni bila dokazana, ker so ostanke v tkivu zaznali le enkrat ali dvakrat po prekinitvi uporabe zdravila.
The most favourable results were obtained at the highest dose tested, i.e. 1000 ppm corresponding to 196 mg/kg body weight for 5 days.
Najugodnejše rezultate so dobili pri največjem preskušenem odmerku, tj. 1 000 ppm, kar ustreza 196 mg/kg telesne mase za 5 dni.
Nine responses were with generic dossiers developed in accordance with the Article 13 of Directive 2001/82/EC.
Devet odgovorov je vsebovalo generično dokumentacijo, ki je bila pripravljena v skladu členom 13 Direktive 2001/82/ES.
There was no documented evidence indicating a new risk associated with the use of doxycycline in poultry in relation to lack of efficacy.
Ni bilo dokumentiranih dokazov o novem tveganju, povezanem z uporabo doksiciklina pri perutnini v zvezi z neučinkovitostjo.
Riudoms 43330 (Tarragona) SPAIN
Riudoms 43330 (Tarragona) ŠPANIJA
Therefore the product should be used for the treatment of infections caused by E. coli only after susceptibility testing has been carried out.
Zato je treba zdravilo uporabljati za zdravljenje okužb z E. coli šele po izvedenem testu občutljivosti.
Despite the deficiencies in the submitted studies and lack of data for some indications and dosages on the basis of well established use and the lack of any new pharmacovigilance information in relation to lack of efficacy it can be concluded that the current dosages and indications for the doxycycline containing products can be considered safe and effective.
Kljub pomanjkljivostim predloženih študij, pomanjkanju podatkov za določene indikacije in odmerke na podlagi dobro uveljavljene rabe ter odsotnosti novih farmakovigilančnih podatkov v zvezi z neučinkovitostjo se lahko zaključi, da so trenutni odmerki in indikacije za zdravila, ki vsebujejo doksiciklin, varni in učinkoviti.
Bulgaria Farma Sis OOD 4 San Stefano Str.
Bolgarija Farma Sis OOD 4 San Stefano Str.
As regards Escherichia coli infections, three publications of experimental model studies (George et al., 19772; Goren et al., 19883, Velkers et al., 20054) and one clinical efficacy study were presented.
V zvezi z okužbami z Escherichia coli so bile predložene tri objave študij eksperimentalnih modelov (George et al., 19772; Goren et al., 19883, Velkers et al., 20054) in ena klinična študija učinkovitosti.
However the article of George et al. (1977)2 does not include sufficient information (body weights and water consumption) to calculate the daily actual dose intake of the study animals.
Vendar v prispevku George et al. (1977)2 ni dovolj informacij (glede telesne mase in porabe vode) za izračun dejanskega dnevnega vnesenega odmerka pri proučevanih živalih.
Nutri-Biomed Hellas LTD 1,V.Hugo &Chlois Metamorfosi Attikis 14452 Athens GREECE
Nutri-Biomed Hellas LTD 1,V.Hugo &Chlois Metamorfosi Attikis 14452 Athens GRČIJA
Romania PHARMATEKA BT 1046 Budapest
Romunija PHARMATEKA BT 1046 Budapest
Trei Bio pharmaceutical division, Industria Italiana Integratori Trei
Slovaška Trei Bio pharmaceutical division, Industria Italiana Integratori Trei
Arendonk BELGIUM
Arendonk BELGIJA
POL.IND.MECANOV A, NAVES 27-28 25191 LLEIDA SPAIN
POL.IND.MECANOV A, NAVES 27-28 25191 LLEIDA ŠPANIJA
2370 Arendonk BELGIUM
2370 Arendonk BELGIJA
It is primiraly a bacteriostatic antibiotic and has its main mechanism of action on inhibition of protein synthesis.
Doksiciklin je predvsem bakteriostatičen antibiotik, njegov glavni mehanizem delovanja pa je zaviranje sinteze beljakovin.
Doxycycline is a tetracycline derivative with uses similar to those of tetracycline.
Doksiciklin je tetraciklinski derivat, ki ga uporabljamo podobno kot tetraciklin.
Laboratoires Biove 3 rue de Lorraine 62510 Arques FRANCE
Francija Laboratoires Biove 3 rue de Lorraine 62510 Arques
1093 Budapest HUNGARY
1093 Budapest MADŽARSKA
In particular, information about the study conditions (medical history of the study site, housing and feeding conditions, light/dark cycle) as well as the treatment schedule (medication ad libitum for 24 hours/ pulse medication) was missing or very limited.
Večinoma so manjkale informacije o pogojih študije (medicinska anamneza na mestu študije, pogoji bivanja in krmljenja, ciklusi svetlobe/teme) ter urnik zdravljenja (zdravila ad libitum za 24 ur/pulzno zdravljenje) ali pa so bile te zelo omejene.
PARCELA409-410 25191 Lérida SPAIN
PARCELA409-410 25191 Lérida ŠPANIJA
List of the names, pharmaceutical forms, strengths of the veterinary medicinal products, animal species, route of administration, indications / withdrawal periods and applicants / marketing authorisation holders in the Member States
SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI, ŽIVALSKIH VRST, POTI UPORABE, INDIKACIJ/KARENC IN PREDLAGATELJEV/IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
mg/kg/day (pigs)
mg/kg/dan (prašiči)
However the publication does not provide sufficient information to calculate the actual dose intake of the study animals.
Vendar objava ne vsebuje dovolj informacij za izračun dejanskega vnosa odmerka pri proučevanih živalih.
10 rue Clement Ader
Francija Noe 10 rue Clement Ader
Tierarzneimittel Gesellschaft m.b.H.Kaplanstraß e 10 AT
Avstrija Chevita Tierarzneimittel Gesellschaft m.b.H.Kaplanstraß e 10 AT
However, the publication did not include the necessary information to derive a daily actual dose intake of the study birds.
Vendar v objavo niso vključili informacij, potrebnih za izpeljavo dnevnega dejanskega vnesenega odmerka pri proučevanih pticah.
47100 Forli ITALY
47100 Forli ITALIJA
Via Augusta, 302 08017 Barcelona SPAIN
Via Augusta, 302 08017 Barcelona ŠPANIJA
As regards Pasteurella multocida infection, two experimental studies in broiler chickens were presented, i.e. one publication (Semjen et al., (1998)1, and one proprietary study.
V zvezi z okužbo s Pasteurella multocida sta bili predstavljeni dve eksperimentalni študiji pri pitovnih piščancih, tj. ena objava (Semjen et al., (1998))1 in ena lastniška študija.
As regards P. multocida infections, results of an experimental model study indicate a treatment dose of 10 mg/kg body weight for 4 or 5 days, but no confirmatory clinical data obtained under commercial conditions has been made available.
V zvezi z okužbami s P. multocida rezultati študije na poskusnih modelih kažejo terapevtski odmerek 10 mg/kg telesne mase 4 ali 5 dni, vendar potrditveni klinični podatki v komercialnih okoliščinah niso bili na voljo.
Barcelona, 411 08620 San Vicens del Horts SPAIN
Barcelona, 411 08620 San Vicens del Horts ŠPANIJA
At this dose levels mean plasma doxycycline levels of 3.6 µg/ml (measured on the 2nd treatment day were achieved.
Pri tej koncentraciji so povprečne ravni doksiciklina v plazmi 3,6 µg/ml (izmerjeno 2. dan zdravljenja).
Hungary Kon-Pharma GmbH.
Madžarska Kon-Pharma GmbH.
Hungary Phylaxia Pharma Zrt.
Madžarska Phylaxia Pharma Zrt.
Therefore, CVMP recommends that the product literature for all concerned products in this procedure should include appropriate prudent use statements in line with what is recommended in the CVMP Guideline on the SPC for antimicrobials (EMEA/CVMP/SAGAM/383441/2005)8 and information on correct administration.
CVMP zato priporoča, da literatura o vseh zdravilih, ki jih zadeva ta postopek, vsebuje ustrezne izjave o preudarni uporabi v skladu s priporočili Smernice CVMP o povzetku glavnih značilnosti protimikrobnih zdravil (EMEA/CVMP/SAGAM/383441/2005)8 in informacije o pravilni uporabi.
71 08503 GURB - VIC SPAIN
71 08503 GURB - VIC ŠPANIJA
Armazém nº 21 Casal do Bagulho Granja de Alpriate 2625-607 Vialonga PORTUGAL
Casal do Bagulho Granja de Alpriate 2625-607 Vialonga PORTUGALSKA
Alternatively, the concentrated solution can be used in a proportional water medicator.
Drugače se lahko koncentrirana raztopina uporabi v napravi za proporcionalno vmešavanje zdravil.
Romania s.c. romvac company s.a.Şos.
Romunija s.c. romvac company s.a.Şos.
Bucharest ROMANIA
Bucharest ROMUNIJA
The use of doxycycline hyclate for all claimed indications in chickens as well as the use of doxycycline hyclate in other poultry species was considered well-established.
Uporaba doksiciklinijevega hiklata za vse predlagane indikacije pri piščancih ter uporaba doksiciklinijevega hiklata pri drugih vrstah perutnine se šteje za dobro uveljavljeno.
The daily doses administered to chickens ranged between 10.36 mg/kg body weight, 14.47 mg/kg body weight and 25 mg/kg body weight.
Dnevni odmerki, uporabljeni pri piščancih, so bili v razponu med 10,36 mg/kg telesne mase, 14,47 mg/kg telesne mase in 25 mg/kg telesne mase.
Zoovetvaru uusaru 5
Estonija Zoovetvaru uusaru 5
Pharmagal s.r.o., Murgašova 5, 949 01 Nitra, Slovak Republic
Pharmagal s.r.o., Murgašova 5, 949 01 Nitra, Slovaška
Different product formulations were used in the studies containing, doxycycline hyclate/hydrochloride at different concentrations; almost all included acidifiers in the formulation (usually citric acid).
V študijah so bile uporabljene različne formulacije zdravil, ki so vsebovale doksiciklinijev hiklat/doksiciklinijev hidroklorid v različnih koncentracijah; v skoraj vseh so bila vključena sredstva za zakisanje (po navadi citronska kislina).
Via W. Tobagi n.7 20068 Peschiera Borromeo (Milano) ITALY
Via W. Tobagi n.7 20068 Peschiera Borromeo (Milano) ITALIJA
The study published by Goren et al. (1988)3 was designed as a dose titration study with doxycycline administered at dosages of 25-1000 ppm in drinking water for 5 consecutive days.
Študija, ki so jo objavili Goren et al. (1988)3, je bila zasnovana kot študija titracije odmerka, v kateri so doksiciklin dajali 5 zaporednih dni v pitno vodo v razponu odmerkov 25-1 000 ppm.
In the proprietary study, diarrhoea was one of the main clinical symptoms observed in infected untreated animals, which is not considered typical for Pasteurellosis.
V lastniški študiji je bila eden od glavnih kliničnih simptomov, ki so jih spremljali pri okuženih nezdravljenih živalih, driska, ki pa se ne šteje kot značilen simptom za pasteurelozo.
Czech republic
Češka republika
However there was no documented evidence for lack of efficacy in the treatment of respiratory infection associated with Mycoplasma gallisepticum with any other of the approved dosage regimens (10-25 mg/kg body weight).
Ni pa dokumentiranih dokazov o neučinkovitosti pri zdravljenju okužb dihal z Mycoplasma gallisepticum pri nobenem od odobrenih režimov odmerjanja (10-25 mg/kg telesne mase)
DOXYVIT 40% per 3-6 L of drinking water
DOXYVIT 40 % na 3-6 l pitne vode
One of these studies serve as the confirmatory evidence for the efficacy of this target dose, based on objective parameters such as a significant reduction of the percentage of animals with pathological lesions and total lesion scores typical of the disease and significant reduction in the recovery rate of M. gallisepticum after treatment.
Ena od teh študij velja kot potrditveni dokaz za učinkovitost tega ciljnega odmerka na podlagi objektivnih parametrov, kot so bistveno zmanjšanja odstotka živali s patološkimi lezijami in skupnim točkovanjem lezij, ki je značilno za bolezen, ter bistveno zmanjšanje stopnje izolacije M. gallisepticum po zdravljenju.
Comparison of these infection studies that investigate Colibacillosis was problematic due to considerable differences in the experimental conditions such as the use of different challenge strains and infectious dose levels, different time of treatment initiation, and differences in the chickens (age, weight, and breed) used.
Primerjava omenjenih študij okužb, v katerih so raziskovali kolibacilozo, je težavna zaradi bistvenih razlik v eksperimentalnih pogojih, kot je uporaba različnih izzivnih sevov in ravni infektivnega odmerka, različnih časov uvedbe zdravljenja in razlik v uporabljenih piščancih (starost, masa, pasma).
The United Kingdom expressed concerns that differences in the posology, dose range, duration of treatment and withdrawal periods established across the European Union for all strengths of water soluble powders and oral solutions containing doxycycline hyclate indicated for use in poultry and intended for administration via drinking water may present a potential serious risk to both animal health and human health, and requested the CVMP to give its opinion on the matter.
Združeno kraljestvo je izrazilo zadržek, da lahko razlike v odmerjanju, razponih odmerkov, trajanju zdravljenja in karencah, ki veljajo v Evropski uniji za vse jakosti vodotopnih praškov in peroralnih raztopin, ki vsebujejo doksiciklinijev hiklat in so indicirani za uporabo pri perutnini ter za dajanje s pitno vodo, pomenijo možno resno tveganje za zdravje živali in ljudi, zato je zaprosilo CVMP, da poda mnenje glede te zadeve.
Via Colleoni n.15 20041 Agrate Brianza (Milano) ITALY
Via Colleoni n.15 20041 Agrate Brianza (Milano) ITALIJA
While the data submitted by Applicants/Marketing Authorisation Holders failed to provide sufficient documented evidence to support the established doses for all other indications and species, there was, however, no new information indicating any new risk associated with the use of doxycycline in poultry in relation to lack of efficacy.
Čeprav podatki, ki so jih predložili predlagatelji/imetniki dovoljenja za promet z zdravilom, niso vsebovali dovolj dokazov v podporo uveljavljenim odmerkom za vse druge indikacije in živalske vrste, ni novih informacij, ki bi kazale novo tveganje, povezano z uporabo doksiciklina pri perutnini v zvezi z neučinkovitostjo.
5530 AD Bladel THE
5530 AD Bladel NIZOZEMSKA
Sogeval Laboratoires 200 route De Mayenne 53 022 Laval Cedex FRANCE
Laboratoires 200 route De Mayenne 53 022 Laval Cedex FRANCIJA
A high resistance rate of E. coli, isolated from chickens, against tetracyclines has been documented.
Ugotovljena je visoka stopnja odpornosti E. coli, izolirane iz piščancev, proti tetraciklinom.
All tetracyclines have a broad spectrum of activity which include Gram-positive and Gram-negative bacteria, chlamydias, rickettsias, mycoplasmas and spirochaetes.
Vsi tetraciklini imajo širok spekter aktivnosti, ki vključujejo grampozitivne in gramnegativne bakterije, klamidije, rikecije, mikoplazme in spirohete.
Romania S.C. Crida pharm s.r.l
Romunija S.C. Crida pharm s.r.l
The data submitted for Chlamydiosis were inconclusive and therefore there was insufficient information to support this indication both in chickens and other target species for the currently approved products that are within the scope of this referral procedure.
Podatki, predloženi za klamidiozo, so bili neprepričljivi, zato je bilo premalo informacij v podporo tej indikaciji pri piščancih in drugih ciljnih živalskih vrstah za trenutno odobrena zdravila, ki so zajeta v obseg tega napotitvenega postopka.
With regard to the E. coli infections in poultry the data submitted was not sufficient.
Podatki, predloženi v zvezi z okužbami z E. coli pri perutnini, so bili nezadostni.
= .... mg [product name] per l drinking water
= .... mg zdravila [ime zdravila] na l pitne vode
As eradication of the target pathogens may not be achieved, medication should therefore be combined with good management practices, e.g. good hygiene, proper ventilation, no overstocking.
Ker izkoreninjenja ciljnih bolezenskih povzročiteljev morda ni možno doseči, je treba zdravilo kombinirati z dobro prakso obvladovanja bolezni, npr. ustrezno higieno, ustreznim prezračevanjem, preprečevanjem naselitve prevelikega števila živali na enoto.
Antimicrobial efficacy as evident from recovery rate of O. rhinotracheale was not confirmed.
Protimikrobna učinkovitost, ki so jo dokazovali s stopnjo izolacije O. rhinotracheale, ni bila potrjena.
Scientific conclusions and grounds for amendment of the summary of product characteristics
ZNANSTVENI ZAKLJUČKI IN PODLAGA ZA DOPOLNILO POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA
Meat - 4 days
meso - 4 dni
Doxycycline was also shown to be superior to chlortetracycline used as positive control.
Dokazali so, da je doksiciklin boljši od klortetraciklina, ki se je uporabil kot pozitivna kontrola.
CHEMO IBERICA, S.A. Gran Via Carlos III, 98 7ª Edificio Trade 08028 Barcelona SPAIN
CHEMO IBERICA, S.A. Gran Via Carlos III, 98 7ª Edificio Trade 08028 Barcelona ŠPANIJA
In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted.
Koncentracijo v pitni vodi bo morda treba prilagoditi tako, da se doseže pravilni odmerek.