natgillin/translations-raw huggingface dataset:
• Salicylates (e.g. aspirin).
• salicilate (npr. aspirin),
Concomitant use of rifampicin and repaglinide might therefore induce a need for repaglinide dose adjustment which should be based on carefully monitored blood glucose concentrations at both initiation of rifampicin treatment (acute inhibition), following dosing (mixed inhibition and induction), withdrawal (induction alone) and up to approximately two weeks after withdrawal of rifampicin where the inductive effect of rifampicin is no longer present.
Zaradi sočasne uporabe rifampicina in repaglinida lahko torej pride do potrebe po prilagajanju odmerka repaglinida, ki bi moralo temeljiti na pazljivem spremljanju vrednosti glukoze v krvi tako ob uvedbi zdravljenja z rifampicinom (akutna inhibicija), ob nadaljnjem odmerjanju (mešana inhibicija in indukcija) kot tudi ob ukinitvi (samo indukcija) in še do približno dva tedna po ukinitvi rifampicina, ko indukcijskega učinka rifampicina ni več.
Alcohol can change the ability of Repaglinide Teva to reduce the blood sugar.
Alkohol lahko spremeni sposobnost zdravila Repaglinid Teva, da zniža sladkor v krvi.
Eight percent of one dose of repaglinide is excreted through the kidneys and total plasma clearance of the product is decreased in patients with renal impairment.
Osem odstotkov posameznega odmerka repaglinida se izloči skozi ledvice in celotni plazemski očistek zdravila je pri bolnikih z okvaro ledvic zmanjšan.
Trials investigating the combination with other insulin secretagogues have not been performed.
Raziskav, ki bi proučile kombinacijo z drugimi sekretagogi insulina, ni bilo.
When repaglinide was given 24 hours after the last rifampicin dose, an 80% reduction of the repaglinide AUC was observed (effect of induction alone).
Če so dali repaglinid 24 ur po zadnjem odmerku rifampicina, so opazili 80% zmanjšanje AUC repaglinida (učinek samo indukcije).
As insulin sensitivity is increased in diabetic patients with renal impairment, caution is advised when titrating these patients.
Ker je občutljivost za insulin pri diabetikih z okvaro ledvic večja, je prilagajanje pri teh bolnikih treba opraviti previdno.
If you take more Repaglinide Teva than you should If you take too many tablets, your blood sugar may become too low, leading to a hypo.
Če ste vzeli večji odmerek zdravila Repaglinid Teva, kot bi smeli Če vzamete preveč tablet, se vam lahko sladkor v krvi preveč zniža, kar lahko vodi do hipe.
The warning signs of a hypo may come on suddenly and can include: cold sweat; cool pale skin; headache; rapid heart beat; feeling sick; feeling very hungry; temporary changes in vision; drowsiness; unusual tiredness and weakness; nervousness or tremor; feeling anxious; feeling confused; difficulty in concentrating.
Opozorilni znaki hipe se lahko pojavijo nenadoma in lahko obsegajo: hladno znojenje, hladno in bledo kožo, glavobol, hitro bitje srca, občutek slabosti, hudo lakoto, prehodne spremembe vida, zaspanost, nenavadno utrujenost in šibkost, živčnost ali tresenje, občutek tesnobe, občutek zmedenosti,
The warning signs of too high blood sugar appear gradually.
Opozorilni znaki previsokega krvnega sladkorja se pojavijo postopoma in lahko obsegajo:
Short-term administration of repaglinide may be sufficient during periods of transient loss of control in type 2 diabetic patients usually controlled well on diet.
Kratkotrajna uporaba repaglinida lahko zadošča v obdobjih prehodne izgube nadzora nad sladkorno boleznijo 2 pri bolnikih, pri katerih je bolezen ponavadi dobro urejena z dieto.
Mechanism of action Repaglinide is a short-acting oral secretagogue.
Repaglinid je kratkodelujoči peroralni sekretagog.
The elevated insulin levels did not persist beyond the time of the meal challenge.
Zvečana koncentracija insulina ni trajala dlje kot je potreben čas za presnovo obroka.
Repaglinide can be given in combination with metformin, when the blood glucose is insufficiently controlled with metformin alone.
Repaglinid je mogoče uporabiti v kombinaciji z metforminom, kadar glukoza v krvi ni zadostno urejena samo z metforminom.
Repaglinide should only be prescribed if poor blood glucose control and symptoms of diabetes persist despite adequate attempts at dieting, exercise and weight reduction.
Repaglinid se sme predpisati le, če se slaba urejenost glukoze v krvi in simptomi sladkorne bolezni nadaljujejo kljub ustrezni dieti, telesni dejavnosti in zmanjšanju telesne mase.
Doses are usually taken within 15 minutes of the meal, but the time may vary from immediately preceding the meal to as long as 30 minutes before the meal.
Odmerek se ponavadi vzame v 15 minutah pred obrokom, vendar se ta čas lahko razlikuje od tik pred obrokom do 30 minut pred njim.
• If the acid level in your blood is raised (diabetic ketoacidosis).
• če imate zvišano koncentracijo kislin v krvi (diabetična ketoacidoza),
The plasma elimination half-life is approximately one hour.
Plazemski razpolovni čas izločanja znaša približno 1
Children and adolescents Do not take this medicine if you are under 18 years of age.
Bolniki, mlajši od 18 let, tega zdravila ne smejo jemati.
• Clarithromycin, trimethoprim, rifampicin (antibiotic medicines).
• klaritromicin, trimetoprim, rifampicin (antibiotiki),
The use of repaglinide might be associated with an increased incidence of acute coronary syndrome (e.g. myocardial infarction), see sections 4.8 and 5.1.
Uporabo repaglinida lahko spremlja večja pogostnost akutnega koronarnega sindroma (npr. miokardni infarkt), glejte poglavji 4.8 in 5.1.
• Beta blockers (used to treat high blood pressure or heart conditions).
• zaviralce beta (uporabljajo se za zdravljenje visokega krvnega tlaka ali bolezni srca),
The concomitant use of gemfibrozil and repaglinide is contraindicated (see section 4.3).
Sočasna uporaba gemfibrozila in repaglinida je kontraindicirana (glejte poglavje 4.3).
β-blocking medicinal products may mask the symptoms of hypoglycaemia.
Zaviralci β lahko prikrijejo simptome hipoglikemije.
• Nonsteroidal anti-inflammatory drugs (NSAID) (a type of painkillers).
• nesteroidna protivnetna zdravila (NSAID) (vrsta zdravil proti bolečinam),
Rifampicin, a potent inducer of CYP3A4, but also CYP2C8, acts both as an inducer and inhibitor of the metabolism of repaglinide.
Rifampicin, močan induktor CYP3A4, pa tudi CYP2C8, deluje kot induktor in inhibitor presnove repaglinida.
When these medications are administered to or withdrawn from a patient receiving repaglinide, the patient should be observed closely for changes in glycaemic control.
Ob uvedbi ali ukinitvi zdravljenja s temi zdravili pri bolniku, ki jemlje repaglinid, je treba bolnika natančno spremljati, da bi odkrili spremembe v urejenosti glikemije.
The effect of ketoconazole, a prototype of potent and competitive inhibitors of CYP3A4, on the pharmacokinetics of repaglinide has been studied in healthy subjects.
Vpliv ketokonazola (prototipnega močnega in kompetitivnega zaviralca CYP3A4) na farmakokinetiko repaglinida so raziskali pri zdravih preiskovancih.
30 tablets 90 tablets 120 tablets 270 tablets 360 tablets
30 tablet 90 tablet 120 tablet 270 tablet 360 tablet
It has not been studied in these age groups.
V teh starostnih skupinah zdravilo namreč ni bilo raziskano.
Repaglinide exposure is increased in patients with hepatic insufficiency and in the elderly type 2 diabetic patients.
Izpostavljenost repaglinidu je zvečana pri bolnikih z insuficienco jeter in starejših bolnikih s sladkorno boleznijo tipa 2.
If your blood sugar is low or you feel a hypo coming on: eat glucose tablets or a high sugar snack or drink, then rest.
Če se vam sladkor v krvi preveč zniža ali čutite, da se vam pojavlja hipa: zaužijte tablete glukoze ali prigrizek, ki vsebuje veliko sladkorja in nato počivajte.
• If you exercise less than usual.
• ste manj telesno dejavni kot ponavadi.
Repaglinide Teva is available in pack sizes of 30, 90, 120, 270 and 360 tablets.
Zdravilo Repaglinid Teva je na voljo v pakiranjih po 30, 90, 120, 270 in 360 tablet.
Repaglinide closes ATP-dependent potassium channels in the β-cell membrane via a target protein different from other secretagogues.
Repaglinid v membrani celic β zapre od ATP-odvisne kalijeve kanale, in sicer prek tarčne beljakovine, ki je druga kot pri ostalih sekretagogih.
• If you have a hypo that makes you pass out, or a lot of hypos, talk to your doctor.
• Če doživite hipo, zaradi katere se onesvestite, ali doživljate veliko hip, se posvetujte z zdravnikom.
When symptoms of hypoglycaemia have disappeared or when blood sugar levels are stabilised continue Repaglinide Teva treatment.
Ko simptomi hipoglikemije izginejo ali se raven sladkorja v krvi ustali, nadaljujte zdravljenje z zdravilom Repaglinid Teva.
• If you have type 1 diabetes.
• če imate sladkorno bolezen tipa 1,
Contact a doctor immediately.
Takoj kontaktirajte svojega zdravnika.
You can take Repaglinide Teva with metformin, another medicine for diabetes, if your doctor prescribes it.
Zdravilo Repaglinid Teva lahko vzamete z metforminom, drugim zdravilom za zdravljenje sladkorne bolezni, če vam zdravnik tako predpiše.
What Repaglinide Teva is and what it is used for What you need to know before you take Repaglinide Teva How to take Repaglinide Teva Possible side effects
Kaj je zdravilo Repaglinid Teva in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Repaglinid Teva Kako jemati zdravilo Repaglinid Teva
• Octreotide (used to treat cancer).
• oktreotid (uporablja se za zdravljenje raka),
Repaglinide Teva with alcohol
Zdravilo Repaglinid Teva skupaj z alkoholom
Repaglinide has been shown to lower the blood sugar, which helps to prevent complications from your diabetes.
Zdravilo Repaglinid Teva dokazano znižuje vrednost krvnega sladkorja, kar pomaga preprečiti razvoj zapletov zaradi sladkorne bolezni.
The following substances may reduce the hypoglycaemic effect of repaglinide: Oral contraceptives, rifampicin, barbiturates, carbamazepine, thiazides, corticosteroids, danazol, thyroid hormones and sympathomimetics.
Naslednje snovi lahko zmanjšajo hipoglikemični učinek repaglinida: peroralni kontraceptivi, rifampicin, barbiturati, karbamazepin, tiazidi, kortikosteroidi, danazol,
Repaglinide Teva is not recommended in patients with moderate liver disease.
Uporaba zdravila Repaglinid Teva ni priporočljiva za bolnike z zmerno boleznijo jeter.
Clinical data in healthy volunteers support CYP2C8 as being the most important enzyme involved in repaglinide metabolism with CYP3A4 playing a minor role, but the relative contribution of CYP3A4 can be increased if CYP2C8 is inhibited.
Klinični podatki pridobljeni na zdravih prostovoljcih potrjujejo domnevo, da je CYP2C8 najbolj pomemben encim pri presnovi repaglinida in da ima CYP3A4 manjšo vlogo, vendar pa se relativen prispevek CYP3A4 lahko poveča, kadar je CYP2C8 inhibiran.
There is no reason to suspect cross-allergenicity with sulphonylurea due to the difference in chemical structure.
Navzkrižnih alergijskih reakcij z derivati sulfonilsečnine zaradi različne kemične zgradbe ni pričakovati.
Dosage adjustment of these compounds when co-administered with repaglinide is therefore not necessary.
Zato prilagoditev odmerjanja teh zdravil med sočasno uporabo z repaglinidom ni potrebna.
Your doctor will work out your dose.
Zdravnik vam bo priporočil odmerek.
Method of administration Repaglinide should be taken before main meals (i.e. preprandially).
Bolnik mora repaglinid vzeti pred glavnimi obroki (tj. predprandialno).
• Ciclosporin (used to suppress the immune system).
• ciklosporin (uporablja se za zavrtje imunskega sistema),
• Itraconazole, ketokonazole (antifungal medicines).
• itrakonazol, ketokonazol (zdravila proti glivicam),
After reaching a maximum, the plasma level decreases rapidly.
Potem, ko doseže največjo vrednost, se plazemska koncentracija hitro zmanjša.
• Hypersensitivity (such as rash, itchy skin, reddening of the skin, swelling of the skin)
• preobčutljivost (npr. izpuščaj, srbeča koža, pordelost kože, oteklost kože)
Patients receiving other oral hypoglycaemic medicinal products Patients can be transferred directly from other oral hypoglycaemic medicinal products to repaglinide.
Bolniki, ki dobivajo druge peroralne antidiabetike Bolniki lahko preidejo na repaglinid neposredno z drugih peroralnih antidiabetikov.
The starting dose of repaglinide is 0.5 mg, taken before main meals; titration is according to blood glucose response as for monotherapy.
Začetni odmerek repaglinida je 0,5 mg pred glavnimi obroki; prilagajanje odmerka poteka glede na odziv glukoze v krvi, tako kot pri monoterapiji.
Repaglinide is also indicated in combination with metformin in adults with type 2 diabetes mellitus who are not satisfactorily controlled on metformin alone.
Uporaba repaglinida je indicirana tudi v kombinaciji z metforminom pri odraslih bolnikih s sladkorno boleznijo tipa 2, ki niso zadovoljivo urejeni samo z metforminom.
Seven days pre-treatment with rifampicin (600 mg), followed by co-administration of repaglinide (a single dose of 4 mg) at day seven resulted in a 50% lower AUC (effect of a combined induction and inhibition).
Pri sedemdnevnem pred-zdravljenju z rifampicinom (600 mg), ki mu je sedmi dan sledil odmerek repaglinida (v enkratnem odmerku 4 mg) sedmi dan, se je AUC znižala za 50% (učinek kombinacije indukcije in inhibicije).
• Danazol (used to treat breast cysts and endometriosis).
• danazol (uporablja se za zdravljenje cist na dojkah in endometrioze),
• Steroids (anabolic steroids and corticosteroids - used for anemia or to treat inflammation).
• steroide (anabolne steroide in kortikosteroide za zdravljenje anemije ali vnetja),
Repaglinide Teva is used to control type 2 diabetes in adults as an add-on to diet and exercise: treatment is usually started if diet, exercise and weight reduction alone have not been able to control (or lower) your blood sugar.
Zdravilo Repaglinid Teva se uporablja za obvladovanje sladkorne bolezni tipa 2 pri odraslih bolnikih kot dodatek k dieti in telesni dejavnosti: zdravljenje je treba začeti, če dieta, telesna dejavnost in zmanjšanje telesne mase same ne uspejo obvladati (ali znižati) vaše koncentracije sladkorja v krvi.
• Severe liver problems, abnormal liver function such as increased liver enzymes in your blood.
• hude težave z jetri, moteno delovanje jeter, zvišani jetrni encimi v krvi
No significant effect on the glucose level in healthy volunteers was observed.
Pri zdravih prostovoljcih niso opažali pomembnega vpliva na koncentracijo glukoze.
Other medicines and Repaglinide Teva
Druga zdravila in zdravilo Repaglinid Teva
If you stop taking Repaglinide Teva
Če prenehate jemati zdravilo Repaglinid Teva
Repaglinide Teva should be taken with caution.
Zdravilo Repaglinid Teva morate previdno uporabljati;
Hepatic impairment No clinical studies have been conducted in patients with hepatic insufficiency.
Klinične študije pri bolnikih z jetrno insuficienco niso bilo izvedene.
This lack of pharmacodynamic effect was observed with a sub-therapeutic dose of repaglinide.
Tako odsotnost farmakodinamskega učinka so opazili pri odmerkih repaglinida, ki so nižji od terapevtskih.
Hypersensitivity reactions of the skin may occur as erythema, itching, rashes and urticaria.
Preobčutljivostne kožne reakcije se lahko pojavijo kot eritem, srbenje, izpuščaj ali urtikarija.
It cannot be excluded that other inducers, e.g. phenytoin, carbamazepine, phenobarbital, St John's wort, may have a similar effect.
Ni mogoče izključiti, da imajo podoben učinek tudi drugi induktorji, kot so fenitoin, karbamazepin, fenobarbital in šentjanževka.
The AUC (SD) after 2 mg single dose exposure (4 mg in patients with hepatic insufficiency) was 31.4 ng/ml x hr (28.3) in healthy volunteers, 304.9 ng/ml x hr (228.0) in patients with hepatic insufficiency, and 117.9 ng/ml x hr (83.8) in the elderly type 2 diabetic patients.
AUC (SD) po posamičnem odmerku 2 mg (4 mg pri bolnikih z insuficienco jeter) je bila 31,4 ng/ml x ura (28,3) pri zdravih prostovoljcih, 304,9 ng/ml x ura (228,0) pri bolnikih z insuficienco jeter in 117,9 ng/ml x ura (83,8) pri starejših bolnikih s sladkorno boleznijo tipa 2.
Pack sizes: 30, 90, 120, 270 and 360 tablets.
Na voljo so pakiranja po 30, 90, 120, 270 in 360 tablet.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Če imate kakšna dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom ali s farmacevtom.
Special care should be taken when inhibitors of both CYP2C8 and 3A4 are co-administered simultaneously with repaglinide.
Posebna previdnost je potrebna v primerih istočasne aplikacije zaviralcev tako CYP2C8 kot 3A4 hkrati z repaglinidom.
Half-life was prolonged from 1.3 hr to 3.7 hr, resulting in possibly enhanced and prolonged blood glucose-lowering effect of repaglinide, and plasma repaglinide concentration at 7 hr was increased 28.6-fold by gemfibrozil.
Razpolovni čas se je podaljšal z 1,3 na 3,7 ure, kar bi lahko povečalo in podaljšalo učinek repaglinida na zniževanje glukoze v krvi, koncentracija repaglinida v plazmi po 7 urah pa je bila 28,6-krat večja.
Repaglinide is not affected by renal disorders (see section 5.2).
Okvara ledvic Bolezni ledvic ne vplivajo na repaglinid (glejte poglavje 5.2).
Repaglinide is indicated in adults with type 2 diabetes mellitus whose hyperglycaemia can no longer be controlled satisfactorily by diet, weight reduction and exercise.
4.1 Terapevtske indikacije Uporaba repaglinida je indicirana pri odraslih bolnikih s sladkorno boleznijo tipa 2, pri katerih hiperglikemije ni več mogoče zadovoljivo obvladovati z dieto, zmanjšanjem telesne mase in telesno dejavnostjo.
Repaglinide Teva can also be given with metformin, another medicine for diabetes.
Zdravilo Repaglinid Teva se lahko uporablja tudi z metforminom, prav tako zdravilom za zdravljenje sladkorne bolezni.
• Thiazides (diuretics or ‘water pills').
• tiazide (diuretike ali “zdravila za odvajanje vode”),
Store in the original package in order to protect from light.
Zdravilo shranjujte v originalni ovojnini za zaščito pred svetlobo.
Pharmacotherapeutic group: Drugs used in diabetes, other blood glucose lowering drugs, excl. insulins, ATC code: A10BX02
Farmakoterapevtska skupina: Drugi antidiabetiki razen insulinov, oznaka ATC: A10B X02.
Paediatric population No interaction studies have been performed in children and adolescents.
Študij medsebojnega delovanja z drugimi zdravili pri otrocih in mladostnikih niso izvedli.
• Phenytoin, carbamazepine, phenobarbital (used to treat epilepsy).
• fenitoin, karbamazepin, fenobarbital (za zdravljenje epilepsije),
How to store Repaglinide Teva Contents of the pack and other information
Shranjevanje zdravila Repaglinid Teva Vsebina pakiranja in dodatne informacije
Since the safety profile of this combination has not been established with dosages higher than 0.25 mg for repaglinide and 320 mg for trimethoprim, the concomitant use of trimethoprim with repaglinide should be avoided.
Ker varnostni profil te kombinacije zdravil še ni bil ugotovljen za odmerke višje od 0,25 mg za repaglinid in 320 mg za trimetoprim, se je potrebno sočasni uporabi trimetoprima in repaglinida izogibati.
Repaglinide had no clinically relevant effect on the pharmacokinetic properties of digoxin, theophylline or warfarin at steady state, when administered to healthy volunteers.
Repaglinid pri zdravih prostovoljcih ni klinično pomembno vplival na farmakokinetične lastnosti digoksina, teofilina ali varfarina v stanju dinamičnega ravnovesja.
Repaglinide is rapidly absorbed from the gastrointestinal tract, which leads to a rapid increase in the plasma concentration of the active substance.
Repaglinid se hitro absorbira iz prebavil, zato se njegova koncentracija v plazmi hitro zveča.
• If you are under 18 or over 75 years of age.
• če ste mlajši od 18 ali starejši od 75 let, uporaba zdravila Repaglinid Teva ni priporočljiva.
• Sympathomimetics (used to treat asthma).
• simpatikomimetike (uporabljajo se za zdravljenje astme),
If you take gemfibrozil (used to lower increased fat levels in the blood) you should not take Repaglinide Teva.
Če jemljete gemfibrozil (zdravilo za zdravljenje povišanih maščob v krvi) ne jemljite zdravila Repaglinid Teva.
Repaglinide Teva should not be taken if you have a severe liver disease (see Do not take Repaglinide Teva).
Zdravilo Repaglinid Teva ne smejo jemati bolniki s hudo boleznijo jeter (glejte odstavek Ne jemljite zdravila Repaglinid Teva);
Hypoglycaemia Repaglinide, like other insulin secretagogues, is capable of producing hypoglycaemia.
Tako kot drugi sekretagogi insulina lahko tudi repaglinid povzroči hipoglikemijo.
Repaglinide is given preprandially and is titrated individually to optimise glycaemic control.
Odmerjanje Repaglinid se uporablja predprandialno in ga je treba za optimiranje urejenosti glukoze v krvi individualno prilagoditi.
The following substances may enhance and/or prolong the hypoglycaemic effect of repaglinide: Gemfibrozil, clarithromycin, itraconazole, ketokonazole, trimethoprim, ciclosporin, deferasirox, clopidogrel, other antidiabetic substances, monoamine oxidase inhibitors (MAOI), non selective beta blocking substances, angiotensin converting enzyme (ACE)-inhibitors, salicylates, NSAIDs, octreotide, alcohol, and anabolic steroids.
klaritromicin, itrakonazol, ketokonazol, trimetoprim, ciklosporin, deferasiroks, klopidogrel, drugi antidiabetiki, zaviralci monoaminooksidaze (MAOI), neselektivni zaviralci beta, zaviralci angiotenzinske konvertaze (ACE), salicilati, NSAID, oktreotid, alkohol in anabolni steroidi.
• Thyroid products (used to treat low levels of thyroid hormones).
• zdravila za ščitnico (uporabljajo se za zdravljenje nizke ravni ščitničnih hormonov),
Should these symptoms occur, adequate action should be taken to correct the low blood glucose (oral carbohydrates).
je treba ustrezno ukrepati, da bi odpravili nizko glukozo v krvi (zaužitje ogljikovih hidratov).
Repaglinide should be used with caution or be avoided in patients receiving medicinal products which influence repaglinide metabolism (see section 4.5).
Pri bolnikih, ki dobivajo zdravila z vplivom na presnovo repaglinida, morate repaglinid uporabiti previdno ali se mu izogniti (glejte poglavje 4.5).
• Monoamine oxidase inhibitors (MAOI) (used to treat depression).
• zaviralce monoaminooksidaze (zaviralce MAO) (za zdravljenje depresij),
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Co-administration of 100 mg itraconazole, an inhibitor of CYP3A4, has also been studied in healthy volunteers, and increased the AUC by 1.4-fold.
Pri zdravih prostovoljcih so raziskali tudi sočasno uporabo 100 mg itrakonazola, inhibitorja CYP3A4, pri čemer se je AUC zvečal za 1,4-krat.
Repaglinide Teva is an oral antidiabetic medicine containing repaglinide which helps your pancreas produce more insulin and thereby lower your blood sugar (glucose).
Kaj je zdravilo Repaglinid Teva in za kaj ga uporabljamo Zdravilo Repaglinid Teva je peroralni antidiabetik z repaglinidom, ki trebušni slinavki pomaga, da tvori več insulina, in tako znižuje sladkor v krvi (glukozo).
How to take Repaglinide Teva
Kako jemati zdravilo Repaglinid Teva
• If you exercise more than usual.
• jeste več kot ponavadi,
In debilitated or malnourished patients the initial and maintenance dosage should be conservative and careful dose titration is required to avoid hypoglycaemic reactions.
Pri oslabelih in podhranjenih bolnikih mora biti začetno in vzdrževalno odmerjanje konzervativno;
In vitro data indicate that repaglinide is metabolised predominantly by CYP2C8, but also by CYP3A4.
Podatki in vitro raziskav nakazujejo, da se repaglinid presnavlja pretežno z CYP2C8, vendar tudi z
• Gemfibrozil (used to treat high blood fats).
• gemfibrozil (zdravilo za zdravljenje povišanih maščob v krvi),
• If you take too much Repaglinide Teva.
• ste vzeli preveč zdravila Repaglinid Teva,
Co-administration of cimetidine, nifedipine, oestrogen, or simvastatin with repaglinide, all CYP3A4 substrates, did not significantly alter the pharmacokinetic parameters of repaglinide.
Sočasna uporaba drugih snovi, ki se presnavljajo s CYP3A4, npr. cimetidina, nifedipina, estrogena ali simvastatina z repaglinidom, ni pomembno spremenila farmakokinetičnih lastnosti repaglinida.