natgillin/translations-raw huggingface dataset:
The risk for hypokalaemia may be increased in patients with cirrhosis of the liver, in patients experiencing brisk diuresis, in patients with an inadequate oral intake of electrolytes and in patients receiving concomitant therapy with corticosteroids or adrenocorticotropic hormone (ACTH).
Tveganje hipokaliemije se lahko poveča pri bolnikih s cirozo jeter, bolnikih, ki se jim pojavi hitra diureza, bolnikih, ki ne uživajo dovolj elektrolitov, in tistih, ki sočasno dobivajo kortikosteroide ali adrenokortikotropni hormon (ACTH).
In hypertensive patients, Atacand Plus results in a dose-dependent and long-lasting reduction in arterial blood pressure without reflex increase in heart rate.
Pri hipertenzivnih bolnikih zdravilo Atacand Plus od odmerka odvisno in dolgotrajno zniža arterijski krvni tlak brez refleksnega povečanja srčne frekvence.
This effect of hydrochlorothiazide seems to be less evident when combined with candesartan cilexetil.
Kaže, da je ta učinek hidroklorotiazida manj opazen med kombinirano uporabo s cileksetilkandesartanatom.
Thiazides may reduce the renal excretion of cytotoxic medicinal products (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Tiazidi lahko zmanjšajo ledvično izločanje citotoksičnih zdravil (npr. ciklofosfamida, metotreksata) in povečajo njihove mielosupresivne učinke.
Breathing difficulties (including lung inflammation and fluid in the lungs).
• Težko dihanje (vključno z vnetjem pljuč in tekočino v pljučih).
Currently there are no data on the use of candesartan cilexetil/hydrochlorothiazide in patients with renal disease/nephropathy, reduced left ventricular function/congestive heart failure and post myocardial infarction.
Trenutno ni podatkov o uporabi cileksetilkandesartanata/hidroklorotiazida pri bolnikih z boleznijo ledvic/nefropatijo, zmanjšanim delovanjem levega prekata/srčnim popuščanjem ali po miokardnem infarktu.
Anticholinergic agents such as atropine and biperiden.
• Antiholinergična zdravila, kakršni sta npr. atropin in biperiden.
Cases of photosensitivity reactions have been reported during use of thiazide diuretics (see section 4.8).
Med uporabo tiazidnih diuretikov so poročali o fotosenzibilnostnih reakcijah (glejte poglavje 4.8).
Treatment with a thiazide diuretic may impair glucose tolerance.
Zdravljenje s tiazidnim diuretikom lahko poslabša toleranco za glukozo.
Thiazides should be discontinued before carrying out tests for parathyroid function.
Tiazide je treba nehati uporabljati pred preiskavami delovanja obščitnic.
Use of candesartan and hydrochlorothiazide with lithium is not recommended.
Uporaba kandesartana in hidroklorotiazida skupaj z litijem ni priporočljiva.
cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperiodol)
ciamemazin, sulpirid, sultoprid, amisulprid, tiaprid, pimozid, haloperidol, droperidol).
Candesartan caused a reduction of red blood cell parameters (erythrocytes, haemoglobin, haematocrit).
Kandesartan je povzročil zmanjšanje eritrocitnih parametrov (eritrociti, hemoglobin, hematokrit).
Concomitant treatment with cyclosporine may increase the risk of hyperuricaemia and gout-type complications.
Sočasno zdravljenje s ciklosporinom lahko poveča tveganje hiperurikemije in zapletov protinske vrste.
Candesartan can not be removed by haemodialysis.
Kandesartana ni mogoče odstraniti s hemodializo.
Anticholinergic agents (e.g. atropine, biperiden) may increase the bioavailability of thiazide-type diuretics by decreasing gastrointestinal motility and stomach emptying rate.
Antiholinergiki (npr. atropin, biperiden) lahko povečajo biološko uporabnost tiazidnih diuretikov, ker zmanjšajo gastrointestinalno motiliteto in hitrost praznjenja želodca.
Treatment with candesartan cilexetil may cause hyperkalaemia, especially in the presence of heart failure and/or renal impairment.
Zdravljenje s cileksetilkandesartanatom lahko povzroči hiperkaliemijo, zlasti če ima bolnik srčno popuščanje in/ali okvaro ledvic.
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Pri bolnikih z okvarjenim delovanjem jeter ali progresivno boleznijo jeter je treba tiazide uporabljati previdno, kajti že majhne spremembe ravnovesja tekočine in elektrolitov lahko sprožijo jetrno komo.
If this happens to you, contact your doctor immediately.
Če se to zgodi, se morate nemudoma posvetovati z zdravnikom.
These work together to lower your blood pressure.
Ti skupaj pomagata znižati krvni tlak.
• Treatment of essential hypertension in adult patients whose blood pressure is not optimally controlled with candesartan cilexetil or hydrochlorothiazide monotherapy.
• zdravljenje esencialne hipertenzije pri odraslih bolnikih, ki krvnega tlaka nimajo optimalno urejenega z monoterapijo s cileksetilkandesartanatom ali hidroklorotiazidom.
A severe rash, that develops quickly, with blistering or peeling of the skin and possibly blistering in the mouth.
• Hud izpuščaj, ki nastane hitro in ga spremlja nastajanje mehurjev ali lupljenje kože in lahko tudi nastajanje mehurjev v ustih.
The use of AIIRAs is not recommended during the first trimester of pregnancy (see section 4.4).
ARAII ni priporočljivo uporabljati v prvem trimesečju nosečnosti (glejte poglavje 4.4).
Compounds which have been investigated in clinical pharmacokinetic studies include warfarin, digoxin, oral contraceptives (i.e. ethinylestradiol/levonorgestrel), glibenclamide and nifedipine.
Med učinkovinami, ki so jih raziskali v kliničnih farmakokinetičnih študijah, so varfarin, digoksin, peroralni kontraceptivi (tj. etinilestradiol/levonorgestrel), glibenklamid in nifedipin.
Difficulty in sleeping, depression, being restless.
• Težave s spanjem, depresija, nemir.
Addition of hydrochlorothiazide potentiates the nephrotoxicity of candesartan.
Dodatek hidroklorotiazida poveča nefrotoksičnost kandesartana.
Hydrochlorothiazide decreases plasma volume and extracellular fluid and reduces cardiac output and blood pressure.
Hidroklorotiazid zmanjša volumen plazme in zunajcelične tekočine ter minutni volumen srca in krvni tlak.
In patients with intravascular volume and/or sodium depletion symptomatic hypotension may occur, as described for other agents acting on the renin-angiotensin-aldosterone system.
Bolnikom s pomanjkanjem intravaskularnega volumna in/ali pomanjkanjem natrija se lahko pojavi simptomatska hipotenzija, tako kot je opisano pri drugih zdravilih, ki delujejo na sistem reninangiotenzin-aldosteron.
Atacand Plus can be taken with or without food.
• Zdravilo Atacand Plus lahko vzamete s hrano ali brez nje.
What Atacand Plus looks like and contents of the pack [To be completed nationally]
Izgled zdravila Atacand Plus in vsebina pakiranja [Izpolni država članica]
If this is not sufficient, plasma volume should be increased by infusion of isotonic saline solution.
Če to ne zadošča, je treba povečati volumen plazme z infuzijo, npr. z infuzijo fiziološke raztopine.
There is no clinically significant interaction between hydrochlorothiazide and food.
Med hidroklorotiazidom in hrano ni klinično pomembnih interakcij.
Medicinal products that affect the renin-angiotensin-aldosterone system, including angiotensin II receptor antagonists (AIIRAs), may increase blood urea and serum creatinine in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.
Zdravila, ki vplivajo na sistem renin-angiotenzin-aldosteron, vključno z antagonisti receptorjev angiotenzina II (ARAII), lahko pri bolnikih z bilateralno stenozo ledvične arterije ali stenozo arterije ene same ledvice povečajo koncentracijo sečnine v krvi in kreatinina v serumu.
What Atacand Plus is and what it is used for Before you take Atacand Plus How to take Atacand Plus Possible side effects
Kaj je zdravilo Atacand Plus in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Atacand Plus Kako jemati zdravilo Atacand Plus Možni neželeni učinki
Damage to blood vessels causing red or purple dots in the skin.
• Prizadetost žil, ki povzroči rdeče ali vijoličaste pege na koži.
When Atacand Plus is used in patients with impaired renal function, a periodic monitoring of potassium, creatinine and uric acid levels is recommended.
Med uporabo zdravila Atacand Plus pri bolnikih z okvarjenim delovanjem ledvic so priporočljive redne kontrole kalija, kreatinina in sečne kisline.
Respiratory infection.
• Okužba dihal.
Concomitant administration of candesartan cilexetil and hydrochlorothiazide has no clinically significant effect on the pharmacokinetics of either medicinal product.
Sočasna uporaba cileksetilkandesartanata in hidroklorotiazida ni klinično pomembno vplivala na farmakokinetiko enega ali drugega zdravila.
Foetotoxicity has been observed in late pregnancy with candesartan.
Pri kandesartanu so med pozno nosečnostjo opažali fetotoksičnost.
Medicines to lower your cholesterol, such as colestipol or cholestyramine.
• Zdravila za znižanje holesterola, npr. holestipol ali holestiramin.
The antagonism of the AT1 receptors results in dose related increases in plasma renin levels, angiotensin I and angiotensin II levels, and a decrease in plasma aldosterone concentration.
Posledica antagonizma na receptorjih AT1 je z odmerkom povezano povečanje plazemske koncentracije renina, angiotenzina I in angiotenzina II ter zmanjšanje plazemske koncentracije aldosterona.
Patients with primary hyperaldosteronism generally will not respond to antihypertensive agents acting through inhibition of the renin-angiotensin-aldosterone system.
Bolniki s primarnim aldosteronizmom se praviloma ne odzovejo na antihipertenzivna zdravila, ki zavirajo sistem renin-angiotenzin-aldosteron.
Based on pharmacological considerations, the main manifestation of an overdose of candesartan cilexetil is likely to be symptomatic hypotension and dizziness.
Na podlagi farmakologije sta najverjetnejša glavna znaka prevelikega odmerjanja cileksetilkandesartanata simptomatska hipotenzija in omotica.
If the combination proves necessary, careful monitoring of serum lithium levels is recommended.
Če je takšna kombinacija potrebna, je priporočljivo natančno kontrolirati koncentracijo litija v serumu.
Some of the side effects of Atacand Plus are caused by candesartan cilexetil and some are caused by hydrochlorothiazide.
Nekatere neželene učinke zdravila Atacand Plus povzroči cileksetilkandesartanat, nekatere pa hidroklorotiazid.
Refractory hypokalaemia and hypercalcaemia.
Refraktarna hipokaliemija in hiperkalciemija.
Infants whose mothers have taken AIIRAs should be closely observed for hypotension (see sections 4.3 and 4.4).
Dojenčke mater, ki so prejemale ARAII, je treba natančno kontrolirati glede hipotenzije (glejte tudi poglavji 4.3 in 4.4).
The bioavailability may decrease in patients with cardiac failure and pronounced oedema.
Biološka uporabnost se lahko zmanjša pri bolnikih s srčnim popuščanjem in izrazitimi edemi.
In preclinical safety studies candesartan itself had effects on the kidneys and on red cell parameters at high doses in mice, rats, dogs and monkeys.
V predkliničnih študijah varnosti so veliki odmerki kandesartana samega pri miših, podganah, psih in opicah vplivali na ledvice in eritrocitne parametre.
Rare (affects less than 1 user in 1,000)
Zelo redki (pojavijo se pri manj kot 1 bolniku od 10.000 bolnikov)
Exposure to AIIRA therapy during the second and third trimesters is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalaemia) (see section 5.3).
Znano je, da ima izpostavljenost ARAII v drugem in tretjem trimesečju pri človeku toksične učinke na plod (zmanjšano delovanje ledvic, oligohidramnij, zapoznela osifikacija lobanje) in novorojenčka (odpoved ledvic, hipotenzija, hiperkaliemija) (glejte poglavje 5.3).
The terminal half-life (t½) of candesartan is approximately 9 hours.
Terminalni razpolovni čas (t1/2) kandesartana je približno 9 ur.
Thiazides, including hydrochlorothiazide, can cause fluid or electrolyte imbalance (hypercalcaemia, hypokalaemia, hyponatraemia, hypomagnesaemia and hypochloraemic alkalosis).
Tiazidi, vključno s hidroklorotiazidom, lahko povzročijo neravnovesje tekočine ali elektrolitov (hiperkalciemijo, hipokaliemijo, hiponatriemijo, hipomagneziemijo in hipokloremično alkalozo).
When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6).
Zdravljenje z ARAII je treba končati takoj po ugotovitvi nosečnosti in uvesti drugo zdravljenje, če je to primerno (glejte poglavji 4.3 in 4.6).
Hydrochlorothiazide The terminal t½ of hydrochlorothiazide is prolonged in patients with renal impairment.
Hidroklorotiazid Terminalni t1/2 hidroklorotiazida je pri bolnikih z okvaro ledvic podaljšan.
Thiazide may increase the risk of adverse effects caused by amantadine.
Tiazidi lahko povečajo tveganje neželenih učinkov amantadina.
Tingling or prickling in your arms or legs.
• Mravljinčenje v rokah ali nogah.
It contains two active ingredients: candesartan cilexetil and hydrochlorothiazide.
Vsebuje dve zdravilni učinkovini: cileksetilkandesartanat in hidroklorotiazid.
Dose titration with the individual components (candesartan cilexetil and hydrochlorothiazide) is recommended.
Priporočljivo je titriranje odmerka s posameznima sestavinama (cileksetilkandesartanatom in hidroklorotiazidom).
Concomitant use of Atacand Plus and potassium-sparing diuretics, potassium supplements or salt substitutes or other medicinal products that may increase serum potassium levels (e.g. heparin sodium) may lead to increases in serum potassium.
Sočasna uporaba zdravila Atacand Plus in diuretikov, ki varčujejo s kalijem, dodatkov kalija, nadomestkov soli ali drugih zdravil, ki lahko povečajo koncentracijo kalija v serumu (npr. natrijevega heparinata), lahko hipertenzivnim bolnikom poveča koncentracije kalija v serumu.
Thiazide diuretics may decrease the urinary calcium excretion and may cause intermittent and slightly increased serum calcium concentrations.
Tiazidni diuretiki lahko zmanjšajo izločanje kalcija v urinu in lahko povzročijo intermitentno in rahlo povečanje koncentracije kalcija v serumu.
Your doctor may prescribe Atacand Plus if your blood pressure has not been properly controlled by candesartan cilexetil or hydrochlorothiazide alone.
Zdravnik vam lahko predpiše zdravilo Atacand Plus, če vam krvnega tlaka ni bilo mogoče ustrezno urediti s samim cileksetilkandesartanatom ali hidroklorotiazidom.
Amphotericin (for the treatment of fungal infections).
• Amfotericin (za zdravljenje glivičnih okužb).
In clinical trials with candesartan cilexetil/hydrochlorothiazide, adverse reactions were limited to those that were reported previously with candesartan cilexetil and/or hydrochlorothiazide.
V kliničnih preskušanjih s cileksetilkandesartanatom/hidroklorotiazidom so bili neželeni učinki omejeni na tiste, ki so bili že pred tem opisani s cileksetilkandesartanatom in/ali hidroklorotiazidom.
• Class III antiarrhythmics (e.g. amiodarone, sotalol, dofetilide, ibutilide)
• antiaritmiki iz skupine III (kot so npr. amiodaron, sotalol, dofetilid, ibutilid).
In a pooled analysis of clinical trial data of hypertensive patients, adverse reactions with candesartan cilexetil were defined based on an incidence of adverse events with candesartan cilexetil at least 1% higher than the incidence seen with placebo.
V skupni analizi podatkov kliničnih preskušanj pri hipertenzivnih bolnikih so bili neželeni učinki s cileksetilkandesartanatom opredeljeni kot incidenca neželenih učinkov s cileksetilkandesartanatom, vsaj 1 % večja od tiste s placebom.
This is because Atacand Plus, when combined with some anaesthetics, may cause a drop in blood pressure.
V kombinaciji z nekaterimi anestetiki namreč zdravilo Atacand Plus lahko povzroči padec krvnega tlaka.
you have persistently low levels of potassium in your blood.
- če imate trajno nizek kalij v krvi.
Candesartan and hydrochlorothiazide both show genotoxic activity at very high concentrations/doses.
Kandesartan in hidroklorotiazid v zelo velikih koncentracijah/odmerkih oba delujeta genotoksično.
In patients with mild to moderate renal impairment, Cmax and AUC of candesartan increased during repeated dosing by approximately 50% and 70%, respectively, but the terminal t½ was not altered, compared to patients with normal renal function.
Pri bolnikih z blago do zmerno okvaro ledvic sta se Cmax in AUC kandesartana med večkratnim odmerjanjem povečali za približno 50 % (Cmax) in 70 % (AUC), terminalni t1/2 pa se ni spremenil v primerjavi z bolniki z normalnim delovanjem ledvic.
In individual case reports of overdose (of up to 672 mg candesartan cilexetil) patient recovery was uneventful.
Opisani so posamezni primeri prevelikega odmerjanja (do 672 mg cileksetilkandesartanata).
Atacand Plus is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Če želite dojiti, vam bo zdravnik najbrž izbral drugo zdravilo, še zlasti če je vaš otrok novorojenček ali je bil rojen prezgodaj.
Metformin should be used with caution because of the risk of lactic acidosis induced by possible functional renal failure linked to hydrochlorothiazide.
Metformin je treba uporabljati previdno: zaradi možne funkcijske odpovedi ledvic, povezane s hidroklorotiazidom, namreč obstaja tveganje laktacidoze.
Atacand Plus is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Če ste noseči več kot 3 mesece, pa ga sploh ne smete jemati, kajti njegovo jemanje po tretjem mesecu nosečnosti lahko otroku resno škoduje.
The use of Atacand Plus during breast-feeding is not recommended.
Uporaba zdravila Atacand Plus med obdobjem dojenja ni priporočljiva.
Periodic determination of serum electrolytes should be performed at appropriate intervals.
V ustreznih presledkih so potrebne redne kontrole elektrolitov v serumu.
Atacand Plus is contraindicated in patients with severe renal impairment (creatinine clearance < 30 ml/min/1.73 m2 BSA) (see section 4.3).
Zdravilo Atacand Plus je kontraindicirano pri bolnikih s hudo okvaro ledvic (očistek kreatinina < 30 ml/min/1,73 m2 telesne površine) (glejte poglavje 4.3).
Diuretic-induced hypokalaemia and hypomagnesaemia predisposes to the potential cardiotoxic effects of digitalis glycosides and antiarrhythmics.
Z diuretiki povzročena hipokaliemija in hipomagneziemija povečujeta nagnjenost h kardiotoksičnim učinkom digitalisnih glikozidov in antiaritmičnih zdravil.
The potassium depleting effect of hydrochlorothiazide could be expected to be potentiated by other medicinal products associated with potassium loss and hypokalaemia (e.g. other kaliuretic diuretics, laxatives, amphotericin, carbenoxolone, penicillin G sodium, salicylic acid derivates, steroids, ACTH).
Hidroklorotiazid izplavlja kalij in ta učinek lahko stopnjuje sočasna uporaba drugih zdravil, ki jih spremljata izgubljanje kalija in hipokaliemija (npr. drugih kaliuretičnih diuretikov, odvajal, amfotericina, karbenoksolona, natrijevega benzilpenicilinata, derivatov salicilne kisline, steroidov, ACTH).
Steroids such as prednisolone.
• Steroide, npr. prednizolon.
Should exposure to AIIRAs have occurred from the second trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Če od drugega trimesečja nosečnosti naprej pride do izpostavljenosti ARAII, je priporočljivo z ultrazvokom preveriti delovanje ledvic in lobanjo.
If you forget to take use Atacand Plus Do not take a double dose to make up for a forgotten tablet.
Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnjo tableto.
Based on the pharmacological mechanism of action of hydrochlorothiazide its use during the second and third trimesters may compromise foeto-placental perfusion and may cause foetal and neonatal effects like icterus, disturbance of electrolyte balance and thrombocytopenia.
Na podlagi farmakološkega mehanizma delovanja hidroklorotiazida obstaja možnost, da ta med drugim in tretjim trimesečjem poslabša fetoplacentno perfuzijo ter pri plodu in novorojenčku povzroči učinke, kot so zlatenica, motnje ravnovesja elektrolitov in trombocitopenija.
In a randomised, double-blind, parallel group clinical study including 1975 randomised patients not optimally controlled on 32 mg candesartan cilexetil once daily, the addition of 12.5 mg or 25 mg hydrochlorothiazide resulted in additional blood pressure reductions.
V randomizirani, dvojno slepi klinični študiji vzporednih skupin s 1975 randomiziranimi bolniki, ki niso bili optimalno urejeni z 32 mg cileksetilkandesartanata enkrat na dan, je dodatek 12,5 mg ali 25 mg hidroklorotiazida povzročil dodatno znižanje krvnega tlaka.
The corresponding changes in patients with severe renal impairment were approximately 50% and 110%, respectively.
Pri bolnikih s hudo okvaro ledvic je bila sprememba Cmax 50 % in AUC 110 %.
The name of your medicine is Atacand Plus.
Vaše zdravilo se imenuje Atacand Plus.
No pharmacokinetic interactions of clinical significance were identified in these studies.
V teh študijah niso ugotovili klinično pomembnih farmakokinetičnih medsebojnih delovanj.
Loop diuretics are preferred to thiazides in this population.
V tej populaciji imajo diuretiki zanke prednost pred tiazidi.
Take special care with Atacand Plus Before you take, or whilst you are taking Atacand Plus, tell your doctor if:
Bodite posebno pozorni pri jemanju zdravila Atacand Plus Preden vzamete zdravilo Atacand Plus in medtem, ko ga jemljete, morate zdravniku povedati: - če imate sladkorno bolezen.
Therefore Atacand Plus should not be given to children.
Zato otroci ne smejo dobivati zdravila Atacand Plus.
Atacand Plus is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
Če ste noseči več kot 3 mesece, pa ga sploh ne smete jemati, ker lahko otroku resno škoduje, če ga jemljete v tem obdobju (glejte poglavje o nosečnosti).
The candesartan cilexetil/hydrochlorothiazide combination 32 mg/25 mg was significantly more effective than the 32 mg/12.5 mg combination, and the overall mean blood pressure reductions were 16/10 mmHg and 13/9 mmHg, respectively.
Kombinacija cileksetilkandesartanat/hidroklorotiazid 32 mg/25 mg je bila značilno učinkovitejša od kombinacije 32 mg/12,5 mg; celotno povprečno znižanje krvnega tlaka s prvo je bilo 16/10 mmHg in z drugo 13/9 mmHg.
It makes your blood vessels relax and widen.
Deluje tako, da sprosti in razširi žile.
AIIRAs should not be initiated during pregnancy.
Med nosečnostjo se ne sme uvesti zdravljenja z ARAII.
The terminal t½ of hydrochlorothiazide is approximately 8 hours.
Terminalni razpolovni čas (t1/2) hidroklorotiazida je približno 8 ur.
• Some antipsychotics (e.g. thioridazine, chlorpromazine, levomepromazine, trifluoperazine,
• nekaterimi antipsihotiki (kot so npr. tioridazin, klorpromazin, levomepromazin, trifluoperazin,
In a double-blind randomised study, Atacand Plus 16 mg/12.5 mg once daily reduced blood pressure significantly more, and controlled significantly more patients, than the combination losartan/hydrochlorothiazide 50 mg/12.5 mg once daily.
V dvojno slepi, randomizirani študiji je zdravilo Atacand Plus 16 mg/12,5 mg enkrat na dan znižalo krvni tlak značilno bolj in je doseglo urejenost stanja pri značilno več bolnikih kot kombinacija losartan/hidroklorotiazid 50 mg/12,5 mg enkrat na dan.
The table below presents adverse reactions with candesartan cilexetil from clinical trials and post marketing experience.
Spodnja preglednica navaja neželene učinke cileksetilkandesartanata iz kliničnih preskušanj in obdobja trženja.