natgillin/translations-raw huggingface dataset:
What is Zubrin?
Kaj je zdravilo Zubrin?
How has the effectiveness of Zubrin been studied?
Kako je bilo zdravilo Zubrin raziskano?
Zubrin contains the active substance tepoxalin.
Zdravilo Zubrin vsebuje zdravilno učinkovino tepoksalin.
How does Zubrin work?
Kako zdravilo Zubrin deluje?
15 to 21 days
15 do 21 dni
The CVMP can accept:
CVMP lahko sprejme:
This effect is transient.
Ta učinek je prehoden.
The elimination half-life was 22 hours.
Razpolovni čas je bil 22 ur.
See the environmental properties section.
Glejte poglavje o okoljskih lastnostih.
In particular its activity has been demonstrated against the following micro-organism:
Dokazana je aktivnost proti naslednjim mikroorganizmom:
The majority of the marketing authorisations have been approved via national procedures.
Večina dovoljenj za promet z zdravilom je bila odobrena po nacionalnih postopkih.
Applicable to both species:
Velja za obe živalski vrsti:
Soya-bean oil (as stated in the Ph.Eur)
Sojino olje (kakor je navedeno v Ph. Eur)
However, marketing authorisations were also granted via two separate Mutual Recognition Procedures with Italy and Ireland as the Reference Member States.
Vendar so bila dovoljenja za promet z zdravilom odobrena tudi po dveh ločenih postopkih z medsebojnim priznavanjem, v katerih sta bili Italija in Irska referenčni državi članici.
ATCvet code: QJ01FA91.
Oznaka ATC vet: QJ01FA91.
It would give warning that there could be other components (such as other cereals) that could produce the same effect, since the reason for this loss of activity has not been explained in the submission and remained unknown.
To opozarja na možnost, da lahko druge sestavine (kot so druge žitarice) povzročijo enak učinek, ker razlog za to zmanjšanje aktivnosti ni razložen v prijavi in ostaja neznan.
The primary route of environmental exposure is from manure applied to agricultural land as fertilizer.
Primarna pot okoljske izpostavljenosti je prek gnoja, ki se nanese na kmetijske površine kot gnojilo.
2800 Lyngby Denmark
2800 Lyngby Danska
CVMP can also accept the proposed dose in both pigs and rabbits as these are in accordance with those used in the experimental and field studies.
CVMP lahko sprejme tudi predlagani odmerek za prašiče in kunce, saj je skladen z odmerki, uporabljenimi v eksperimentalnih in terenskih študijah.
The uptake of medicated feed depends on the clinical condition of the animals.
Vnos zdravilne krmne mešanice je odvisen od kliničnega stanja živali.
4.2 Indications for Use, Specifying the Target Species: in some Member States the product is indicated for rabbits and in others not.
4.2 Indikacije za uporabo pri ciljnih živalskih vrstah: v nekaterih državah članicah je zdravilo indicirano za kunce, v nekaterih pa ne.
However the bulk of tilmicosin is excreted unchanged.
Vendar pa se večina tilmikozina izloči v nespremenjeni obliki.
• Two sentences should be added in point 4.9: in accordance with the information provided, it has been observed that before incorporation into the finished feed, it was performed a previous mix with a suitable amount of feed.
• dva stavka se dodata v poglavje 4.9: V skladu s predloženimi podatki je bilo ugotovljeno, da se pred dodajanjem v končano krmo opravi predhodno mešanje s primerno količino krme.
Rabbits were approved as target species only in Austria, Belgium, Italy and Luxembourg for Pulmotil 200 Vet premix.
Kunci so bili kot ciljna živalska vrsta odobreni le v Avstriji, Belgiji, Italiji in Luksemburgu za zdravilo Pulmotil 200 Vet premix.
Besides, temperature in the pelleting conditions have not exceeded 75 ºC;
Poleg tega temperature pri peletiranju niso presegle 75 °C;
Where the indications in rabbits are restricted to respiratory infections, the CVMP can accept this claim.
Kadar so indikacije pri kuncih omejene na okužbe dihal, lahko CVMP sprejme to zahtevo.
SPECIAL STORAGE CONDITIONS Store in a dry place.
POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte na suhem mestu.
4.9 Amount to be administered and administered route: the recommended amount to be administered and the treatment duration vary amount the Member States.
4.9 Odmerjanje in pot uporabe: priporočena količina za uporabo in trajanje zdravljenja se razlikujeta med državami članicami.
Macrolides appear to enhance phagocyte killing of bacteria.
Izgleda, da makrolidi pospešijo fagocitno uničevanje bakterij.
Tilmicosin plasma concentrations decreased to 0.1 µg/ml within 2 hours and to 0.02 µg/ml after 8 hours.
Koncentracije tilmikozina v plazmi so se znižale na 0,1 µg/ml v 2 urah ter na 0,02 µg/ml po 8 urah.
Biotransformation: Several metabolites are formed, the predominant one being identified as T1.
Biološka transformacija: Nastane več presnovkov, prevladujočega pa imenujemo T1.
• Indication for pigs: delete the microorganism Haemophilus parasuis;
• indikacija za prašiče: brisanje mikroorganizma Haemophilus parasuis;
In relation to ‘shelf life after incorporation into meal or pelleted feed', CVMP cannot accept the Marketing Authorisation Holders' proposal “ 3 months, except for medicated feed containing 30% wheat in which case the validity is reduced to 1 month”.
V zvezi z „rokom uporabnosti po dodajanju v obrok ali peletirano hrano“ CVMP ne more sprejeti predloga imetnikov dovoljenja za promet z zdravilom, tj. „3 mesece, razen za medicinirano krmo, ki vsebuje 30 % pšenice, kjer se rok skrajša na 1 mesec“.
The CVMP has assessed for the preventive use a pilot study, four dose determination studies and 12 field trial reports.
CVMP je s področja preventivne uporabe ocenil pilotno študijo, štiri študije določitve odmerka in 12 poročil o terenskih preskušanjih.
In relation to the pathogens involved the microorganism Haemophilus parasuis should be removed.
V zvezi z vpletenimi patogenimi mikroorganizmi je treba izbrisati mikroorganizem Haemophilus parasuis.
Lung concentrations increased rapidly between days 2 and 4 but no significant changes were obtained following four days of dosing.
Koncentracije v pljučih se hitro povečujejo od 2. do 4. dne, po 4 dneh odmerjanja pa ni več pomembnih razlik.
Pigs: 21 days Rabbits: 4 days
Prašiči: 21 dni Kunci: 4 dni
Pulmotil VET Premix for medicated feeding stuff is currently registered in 19 EU Member States with three different strengths (40g, 100g and 200g per kg) available.
Zdravilo Pulmotil VET Premix za medicirano krmo je trenutno registrirano v 19 državah članicah EU, pri čemer so na voljo tri jakosti (40 g, 100 g in 200 g na kg).
Read the package leaflet on reverse of the bag before use.
Pred uporabo preberite navodilo na zadnji strani vreče.
• The inclusion rate in feed established at the tables (4.9) would differ on each product strength;
• stopnja dodajanja v krmo na podlagi preglednic (4.9) se razlikuje pri vsaki posamezni jakosti zdravila;
• Modify the special precautions to be taken by the person administering the veterinary medicinal product to animals;
• popravek poglavja Posebni previdnostni ukrepi, ki jih mora izvajati oseba, ki živalim daje zdravilo;
PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: antibacterials for systemic use, macrolides.
Farmakoterapevtska skupina: protibakterijska zdravila za sistemsko uporabo, makrolidi.
Although tilmicosin appears to have an acceptable stability through 3 months at 25 ºC in meal type feeds, in pelleted feeds the behaviour is not the same.
Čeprav se zdi, da ima tilmikozin sprejemljivo stabilnost 3 mesece pri 25 °C v krmi, oblikovani v obrok, pa v peletirani hrani njegovo obnašanje ni enako.
- Do not handle the product if you are allergic to ingredients in the product.
- Na ravnajte z zdravilom, če ste alergični na njegove sestavine.
This product can be incorporated into pelleted feed, preconditioned for the minimum time-period at a temperature not exceeding 75°C.
To zdravilo lahko vmešate v peletirano krmo, predoblikovano za najkrajše časovno obdobje pri temperaturi, ki ne presega 75 °C.
Maximum concentrations were reached in 30 minutes, being the Cmax obtained of 0.35 µg/ml.
Najvišje koncentracije so bile po 30 minutah, pri čemer je bil Cmax 0,35 µg/ml.
Shelf life after first opening the immediate packaging: 3 months is not included in the Marketing Authorisation Holders' proposal, but it is part of the marketing authorisation in 3 Member States.
Rok uporabnosti po prvem odpiranju stične ovojnine: 3 mesece; ni vključen v predlogu imetnikov dovoljenja za promet z zdravilom, vendar je vključen v dovoljenju za promet z zdravilom v 3 državah članicah.
The main sections of disharmony of the existing SPCs (non exhaustive) are:
Poglavitna poglavja neskladnosti v obstoječih povzetkih glavnih značilnosti zdravila so (med drugim):
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with national requirements.
Vsako neporabljeno zdravilo za uporabo v veterinarski medicini ali odpadne snovi, ki nastanejo iz teh zdravil, je treba odstraniti v skladu z lokalnimi predpisi.
In very rare cases, feed intake may decrease (including feed refusal) in animals receiving medicated feed.
V zelo redkih primerih so pri živalih, ki so prejemale zdravilno krmno mešanico, opazili zmanjšan vnos krme (vključno z odklanjanjem).
To ensure thorough dispersion of the product, it should first be mixed with a suitable quantity of feed before incorporation into the finished feed.
Da zagotovite temeljito porazdelitev zdravila, ga morate najprej vmešati v primerno količino krmne mešanice in šele nato v končno krmno mešanico.
For the treatment use, the field trial reports included in the two European Clinical Field Trials Programme (9 field trial in the first phase and 10 field trial in the second phase) and two additional field trial reports were assessed.
S področja terapevtske uporabe je CVMP ocenil poročila o terenskih preskušanjih, vključenih v dve seriji preskušanj v okviru evropskega programa kliničnih terenskih preskušanj (9 terenskih preskušanj v prvi fazi in 10 terenskih preskušanj v drugi fazi), in dve dodatni poročili o terenskih preskušanjih.
• Contraindications: include a new statement in relation to the hypersensitivity to tilmicosin;
• kontraindikacije: vključitev nove izjave v zvezi s preobčutljivostjo za tilmikozin;
As to where the SPC in Austria and Italy include indications that cover enteric disease caused by Clostridia, CVMP concludes that no data have been provided in support of this claim.
V zvezi s tem, kje so v povzetku glavnih značilnosti zdravila v Avstriji in Italiji vključene enteričnih bolezni, ki jih povzročajo klostridiji, CVMP meni, da niso bili predloženi nobeni podatki, ki bi podprli to zahtevo.
LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTHS OF THE VETERINARY MEDICINAL PRODUCTS, ANIMAL SPECIES, ROUTE OF ADMINISTRATION, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATE
DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA ZA UPORABO V VETERINARSKI MEDICINI , ŽIVALSKIH VRST, POTI UPORABE IN IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
It is also distributed in the liver and kidney tissues.
Porazdeli se tudi v tkiva jeter in ledvic.
When mixing the veterinary medicinal product and handling the medicated feed, direct contact with eyes, skin and mucous membranes should be avoided.
Pri mešanju zdravila za uporabo v veterinarski medicini in ravnanju z zdravilno krmno mešanico preprečite stik zdravila z očmi, kožo in sluznicami.
STATEMENT OF ACTIVE AND OTHER SUBSTANCES Active substance:
NAVEDBA ZDRAVILNE(IH) UČINKOVIN(E) IN DRUGIH SNOVI
The CVMP has assessed a PK/PD approach to support use in respiratory disease in rabbit and one clinical trial, as well as bibliographic and pharmacovigilance data provided by the
CVMP je ocenil farmakokinetični/farmakodinamični pristop za podporo uporabe pri boleznih dihal pri kuncih, eno klinično preskušanje ter bibliografske in farmakovigilančne podatke, ki so jih predložili imetniki dovoljenja za promet z zdravilom.
4.11 Withdrawal period(s): for pigs the withdrawal period granted for the product varies among the Member States from 7 to 21 days before slaughter
4.11 Karenca: odobrena karenca za zdravilo pri prašičih se razlikuje med državami članicami in znaša od 7 do 21 dni pred zakolom.
The CVMP recommends that further changes to the SPC proposed by the Marketing Authorisation Holders are made:
CVMP priporoča, da se v povzetek glavnih značilnosti zdravila, ki so ga predlagali imetniki dovoljenja za promet z zdravilom, vnesejo naslednje spremembe:
• The description of the nature and composition of immediate packaging should be harmonised.
• opis vrste ovojnine in vsebine stične ovojnine je treba uskladiti.
OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF PULMOTIL VET PREMIX
SPLOŠNI POVZETEK ZNANSTVENEGA VREDNOTENJA ZDRAVILA PULMOTIL VET PREMIX
It is noted in relation to the list of excipients, that the difference in formulations of the different product strengths should be resolved by the use of separate SPCs per product strength;
V zvezi s seznamom pomožnih snovi je treba poudariti, da je treba razlike med formulacijami različnih jakosti zdravila odpraviti z uporabo ločenih povzetkov glavnih značilnosti zdravila za vsako posamezno jakost zdravila;
Shelf life of the veterinary medicinal product as packaged for sale: the proposed 2 years is acceptable.
Rok uporabnosti zdravila v pakiranju za prodajo: predlagani rok 2 leti je sprejemljiv.
- The efficacy against infections caused by Haemophilus parasuis in pigs has not been substantiated; - Contraindications should include a statement in relation to the hypersensitivity to tilmicosin; - Due to the likely variability (time, geographical) in the occurrence of the resistance of bacteria for tilmicosin, bacteriological sampling and susceptibility testing are recommended; - The special precautions to be taken by the person administering the veterinary medicinal product to animals need modification; - Information should be provided on pre-mixing before pelleting and pelleting temperature; - The inclusion rate in feed established would differ for each product strength; - The reference to rice hulls should be removed; - The shelf life after first opening of the immediate packaging should be added; - The proven shelf life after incorporation into meal or pelleted feed is 1 month; - The description of the nature and composition of immediate packaging should be harmonised; - The complete SPC should be harmonised in the framework of this referral procedure,
- učinkovitost proti okužbam, ki jih pri prašičih povzroča Haemophilus parasuis, ni utemeljena; - kontraindikacije morajo vsebovati izjavo v zvezi s preobčutljivostjo za tilmikozin; - zaradi verjetne (časovne, geografske) variabilnosti pojavljanja odpornosti bakterij proti tilmikozinu se priporoča odvzem bakteriološkega vzorca in preverjanje občutljivosti; - poglavje Posebni previdnostni ukrepi, ki jih mora izvajati oseba, ki živalim daje zdravilo, je treba popraviti; - vstaviti je treba podatke o predmešanju pred peletiranjem in o temperaturi peletiranja; - stopnja dodajanja v krmo se razlikuje pri vsaki posamezni jakosti zdravila; - odstraniti je treba sklic na luščine riža; - dodati je treba rok uporabnosti po prvem odpiranju stične ovojnine; - dokazani rok uporabnosti po dodajanju v obrok ali peletirano hrano je 1 mesec; - opis vrste ovojnine in vsebine stične ovojnine je treba uskladiti; - celoten povzetek glavnih značilnosti zdravila je treba uskladiti v okviru tega napotitvenega postopka,
- To avoid exposure during preparation of the medicated feed, wear overalls, safety glasses, impervious gloves and wear either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator to European Standard EN140 with a filter to EN143.
uporabite varnostna očala in nepropustne rokavice ter bodisi polovično masko z respiratorjem za enkratno uporabo, skladno z evropskim standardom EN149, bodisi respirator za večkratno uporabo, skladen z evropskim standardom EN140, ki ima nameščen filter, skladen z EN143.
The Marketing Authorisation Holders submitted at the request of CVMP: - an exhaustive list of differences between the SPCs of the product authorized in the member states; - a proposal for a harmonised product information (SPC, labelling and package leaflet), taking into account the latest guidance; - the available relevant data substantiating such proposed harmonised product information.
Imetniki dovoljenja za promet z zdravilom so na zahtevo CVMP predložili: - popoln seznam razlik med povzetki glavnih značilnosti zdravila, ki so odobreni v državah članicah; - osnutek usklajenih informacij o zdravilu (povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo) ob upoštevanju najnovejših priporočil; - razpoložljive zadevne podatke, ki utemeljujejo tako predlagane usklajene informacije o zdravilu.
The highest concentration in the serum (0.23 ±0.08 µg/ml) was recorded on day 10 of medication, but concentrations above the limit of quantification (0.10 µg/ml) were not found in 3 out of 20 animals examined.
Najvišjo koncentracijo v serumu (0,23 ± 0,08 µg/ml) so ugotovili 10. dan zdravljenja, vendar koncentracije nad mejo kvantifikacije (0,10 µg/ml) niso bile zaznane pri 3 od 20 preiskanih živalih.
In conclusion, the recommended shelf life after incorporation into meal or pelleted feed for both target species is 1 month.
Zato je priporočeni rok uporabnosti po dodajanju v obrok ali peletirano hrano za obe ciljni živalski vrsti 1 mesec.
• The shelf life after first opening of the immediate packaging should be added;
• dodati je treba rok uporabnosti po prvem odpiranju stične ovojnine;
Having considered the grounds for referral and the response provided by the Marketing Authorisation Holders, the CVMP concludes that the benefit/risk balance of the products is positive for use in both pigs and rabbits subject to the recommended changes of Summary of the Product Characteristics and product information (Annex III).
Ob upoštevanju podlage za napotitveni postopek ter odgovora imetnikov dovoljenja za promet z zdravilom CVMP meni, da je razmerje med koristmi in tveganji zdravila pozitivno za uporabo pri prašičih in kuncih ob upoštevanju priporočenih sprememb povzetka glavnih značilnosti zdravila in informacij o zdravilu (Dodatek 1).
After 5 days of treatment with medicated feed at a dosage of 200 ppm of Pulmotil, tilmicosin concentrations in lung tissues were of 192 ± 103 µg/g.
Po 5 dneh zdravljenja z zdravilno krmno mešanico z odmerkom 200 ppm zdravila Pulmotil so bile koncentracije tilmikozina v pljučnem tkivu 192 ± 103 µg/g.
The Marketing Authorisation Holders' proposal to harmonise the withdrawal period for both species, on the basis of the pivotal residue studies presented can be accepted:
CVMP lahko sprejme predlog imetnikov dovoljenja za promet z zdravilom, da se karenci za obe živalski vrsti uskladita na podlagi predloženih ključnih študij ostankov:
METHOD AND ROUTE(S) OF ADMINISTRATION In-feed use.
NAČIN IN POT(I) UPORABE ZDRAVILA Za v krmo.
Horses fed with tilmicosin medicated feeds may present signs of toxicity with lethargy, anorexia, reduction of feed consumption, loose stools, colic, distension of the abdomen and death.
Pri konjih, ki zaužijejo krmne mešanice s tilmikozinom, se lahko pojavijo znaki toksičnosti z letargijo, anoreksijo, zmanjšanim vnosom krme, redkejšimi iztrebki, koliko, distenzijo abdomna in poginom.
Pharmaceutical form Strength
Farmacevtska oblika
• Include a new statement in relation to the prudent use: due to the likely variability (time, geographical) in the occurrence of the resistance of bacteria for tilmicosin, bacteriological sampling and susceptibility testing are recommended;
• vključitev nove izjave v zvezi s preudarno rabo: Zaradi verjetne (časovne, geografske) variabilnosti pojavljanja odpornosti bakterij proti tilmikozinu se priporoča odvzem bakteriološkega vzorca in preverjanje občutljivosti;
In respect of the benefit/risk balance for target species rabbit, the CVMP considers that benefit/risk balance is positive: - notwithstanding the fact that the clinical field study using dosage of the product have some shortcomings, the pre-clinical studies and the recent MICs data suggest the effective dosage in feed is 12.5 mg/kg for 7 days in the prevention and treatment of respiratory disease caused by Pasteurella multocida and Bordetella bronchiseptica in rabbits; - rabbit is minor species, with specific problems on availability of authorised veterinary products; - the history of use and the various management steps now set out in the harmonised SPC (bacteriological sampling and susceptibility testing are recommended).
V zvezi z razmerjem med koristmi in tveganji za ciljno živalsko vrsto kunec CVMP meni, da je to razmerje pozitivno: - kljub dejstvu, da ima klinična terenska študija z uporabo odmerka zdravila določene pomanjkljivosti, predklinične študije in nedavni podatki o najmanjših inhibicijskih koncentracijah (MIK) kažejo, da je za preprečevanje in zdravljenje bolezni dihal pri kuncih, ki jih povzročata Pasteurella multocida in Bordetella bronchiseptica, učinkovito odmerjanje v krmi 12,5 mg/kg v obdobju 7 dni; - kunec je manj pomembna vrsta s posebnimi težavami glede razpoložljivosti odobrenih veterinarskih zdravil; - pretekla uporaba in različne stopnje obravnave se lahko sedaj opredelijo v usklajenem povzetku glavnih značilnosti zdravila (priporočena sta odvzem bakteriološkega vzorca in preverjanje občutljivosti).
Horses or other Equidae, must not be allowed access to feeds containing tilmicosin.
Konji in drugi kopitarji ne smejo imeti dostopa do krmnih mešanic, ki vsebuje tilmikozin.
The maximum concentration in lung tissue (2.59±1.01 µg/ml) was recorded on day 10 of medication.
Najvišja koncentracija v pljučnem tkivu (2,59±1,01 µg/ml) je bila zaznana 10. dan zdravljenja.
Absorption: When administered to pigs via the oral route at a dose of 400 mg tilmicosin/kg feed (equivalent to approximately 21.3 mg tilmicosin/kg bodyweight/day), tilmicosin moves rapidly out of the serum into areas of low pH.
Absorpcija: Pri prašičih tilmikozin po peroralnem dajanju odmerka 400 mg/kg krmne mešanice (enakovredno približno 21,3 mg tilmikozina/kg telesne mase/dan) hitro preide iz seruma v področja z nizkim pH.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary No symptoms of overdose have been seen in pigs fed a ration containing levels of tilmicosin up to 80 mg/kg bodyweight (equivalent to 2000 ppm in the feed or ten times the recommended dose) for 15 days.
4.10 Preveliko odmerjanje (simptomi, nujni ukrepi, protistrupi) (če je potrebno) Pri prašičih, ki so 15 dni prejemali obrok z ravnmi tilmikozina do 80 mg/kg telesne mase (enakovredno 2000 ppm v krmni mešanici ali desetkratniku priporočenega odmerka), niso opazili simptomov prevelikega odmerjanja.
100 g tilmicosin per 1000 g Member State Marketing Authorisation Holder
100 g tilmikozina na 1000 g Država članica Imetnik dovoljenja za promet
Not to be incorporated into feeds containing Bentonite.
Zdravila ne smete vmešati v krmne mešanice, ki vsebujejo bentonit.
This referral was related to the divergent national decisions taking by member states in relation with the SPC of the products Pulmotil 40 VET Premix, Pulmotil 100 VET Premix, Pulmotil 200 VET Premix and associated name, raised by Belgium.
Ta napotitveni postopek je sprožila Belgija in se nanaša na različne nacionalne odločitve držav članic glede povzetkov glavnih značilnosti zdravil Pulmotil 40 VET Premix, Pulmotil 100 VET Premix, Pulmotil 200 VET Premix in z njim povezanih imen.
Inappropriate use of the product may increase the prevalence of bacteria resistant to tilmicosin and may decrease the effectiveness of treatment with tilmicosin related substances.
Posebni previdnostni ukrepi za uporabo pri živalih Neprimerna raba zdravila lahko poveča pogostnost bakterij, odpornih proti tilmikozinu, in zmanjša učinkovitost zdravljenja z zdravili, podobnimi tilmikozinu.
In the event of accidental skin contact, wash thoroughly with soap and water.
V primeru nenamernega stika s kožo temeljito sperite z milom in vodo.
Tilmicosin degrades/declines slowly in the soil.
Tilmikozin v prsti razpada počasi.