natgillin/translations-raw huggingface dataset:
Clinical monitoring is indicated, with possible dosage adjustment of amlodipine during the treatment with the inducer and after its withdrawal.
Indicirano je klinično spremljanje z morebitno prilagoditvijo odmerka amlodipina med zdravljenjem z induktorjem in po njegovi prekinitvi.
Very rarely, ACE inhibitors have been associated with a syndrome that starts with cholestatic jaundice or hepatitis and progresses to fulminant necrosis and (sometimes) death.
Zaviralci ACE so bili zelo redko povezani s sindromom, ki se začne s holestatskim ikterusom ali hepatitisom ter napreduje v fulminantno nekrozo in (včasih) smrt.
Weight increase, Weight decrease
Povečanje telesne teže, zmanjšanje telesne teže
The antihypertensive effect of lisinopril usually ensues 1 hour after administration and peaks after 6 hours.
Antihipertenzivni učinek lizinoprila se navadno pojavi eno uro po uporabi in je največji po šestih urah.
• Hypersensitivity to amlodipine or to any other dihydropyridine derivatives.
• Preobčutljivost za amlodipin ali katere koli druge derivate dihidropiridina.
For Lisonorm (new lisinopril 10mg/ amlodipine 5mg combination), a positive benefit/risk ratio had not been established given that the initial bioequivalence study submitted was not conducted with the appropriate control, and that preliminary results of a new bioequivalence study (No.67289) did not allow a full assessment of the benefit risk ratio.
Za zdravilo Lisonorm (nova kombinacija 10 mg lizinoprila/5 mg amlodipina) razmerje med koristmi in tveganji ni bilo ustrezno ugotovljeno, saj prvotno predložena študija biološke enakovrednosti ni bila izvedena v skladu z ustreznim nadzorom, predhodni rezultati nove študije biološke enakovrednosti (št. 67289) pa ne omogočajo popolne ocene razmerja med koristmi in tveganji.
The use of ACE inhibitors is not recommended during the first trimester of pregnancy and they are contraindicated in the second and third trimester.
Uporaba zaviralcev ACE v prvem trimesečju nosečnosti ni priporočljiva, v drugem in tretjem trimesečju pa je njihova uporaba kontraindicirana.
Symptomatic treatment (placing the patient in a supine position, monitoring - and when necessary, support - of cardiac function, blood pressure, fluid and electrolyte balance) is recommended.
Priporoča se simptomatsko zdravljenje (bolnik naj leži na hrbtu, spremljanje (in po potrebi podpora) srčnega delovanja, krvnega tlaka, ravnovesja tekočine in elektrolitov).
Where swelling is confined to the face, lips and extremities, it usually resolves spontaneously; nevertheless, antihistamines may be useful in relieving symptoms.
Kadar je otekanje omejeno na obraz, ustnice in ude, navadno izgine spontano, vendar pa bodo za lajšanje simptomov morda kljub temu primerni antihistaminiki.
Like all medicines, Lisonorm can cause side effects, although not everybody gets them.
Kot vsa zdravila ima lahko tudi zdravilo Lisonorm neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
Abrupt discontinuation of lisinopril treatment is not associated with any substantial rebound effect (blood pressure elevation).
Takojšnja prekinitev zdravljenja z lizinoprilom ni povezana z nobenim posledičnim povratnim učinkom (zvišanjem krvnega tlaka).
No precise dosage recommendations have been established for such cases and, therefore, this medicinal product should be administered with caution to patients with hepatic impairment.
Za take primere niso določili nobenih natančnih priporočil za odmerjanje, zato je treba to zdravilo pri bolnikih z jetrno okvaro uporabljati previdno.
Pharmacokinetic parameters (AUC, Cmax, tmax, half-life) were not different from those observed after administration of the individual components separately.
Farmakokinetični parametri (AUC, Cmax, tmax, razpolovni čas) se niso razlikovali od parametrov, ki so jih opazili po dajanju posameznih zdravilnih učinkovin v monoterapiji.
Lisinopril does not bind to plasma proteins other than ACE; it is not metabolized in the organism and is excreted unchanged in the urine.
Lizinopril se ne veže na druge beljakovine v plazmi razen na ACE; organizem ga ne presnovi, zato se v urinu izloča nespremenjen.
Amlodipine, however, is highly protein-bound and, therefore, dialysis is not likely to be of benefit (see section 4.4.)
Amlodipin pa se v veliki meri veže na beljakovine, zato dializa verjetno ni koristna (glejte poglavje 4.4).
Appropriate measures include the subcutaneous administration of 0.3-0.5 mg adrenaline epinephrine or the slow intravenous administration of 0.1 mg adrenaline, followed by glucocorticoids and antihistamines, with simultaneous monitoring of vital functions.
Ustrezni ukrepi vključujejo subkutano dajanje 0,3-0,5 mg adrenalina ali počasno intravensko dajanje 0,1 mg adrenalina, čemur sledi dajanje glukokortikoidov in antihistaminikov, pri čemer se sočasno spremljajo vitalne funkcije.
Oliguria/Anuria
Oligurija/anurija
Therefore, concomitant administration should be carefully considered and only undertaken with increased caution and regular monitoring of both serum potassium levels and renal function.
Zato je treba skrbno razmisliti o sočasnem dajanju, ki se lahko izvaja samo ob povečani pozornosti in rednem spremljanju ravni kalija v serumu in ledvičnega delovanja.
In case of serious hypotension, the lower extremities should be elevated, and when intravenous administration of fluid does not elicit sufficient response, supportive treatment added-on with administration of peripheral vasopressor agents may be necessary, unless contraindicated.
Če se pojavi huda hipotenzija, je treba dvigniti spodnje ude, in kadar intravensko dajanje tekočine ne sproži zadostnega odziva, bo morda treba dodati tudi podporno zdravljenje s perifernimi vazopresorji, razen če je to kontraindicirano.
• anaesthetics, used in surgery or some dental procedures.
• anestetiki, ki se uporabljajo pri kirurških in nekaterih zobozdravstvenih posegih.
Amlodipine may dilate coronary vessels (arteries and arterioles); it improves oxygen supply to the myocardium both in intact and in ischaemic regions.
Amlodipin lahko razširi koronarne žile (arterije in arteriole); izboljša dovod kisika v nepoškodovane in ishemične regije miokardija.
In controlled clinical trials conducted in diabetic patients, no changes of blood glucose level and no increase in the incidence of hypoglycaemia were ascertained.
V nadzorovanih kliničnih preskušanjih, ki so se opravila pri bolnikih s sladkorno boleznijo, niso ugotovili nobenih sprememb ravni glukoze v krvi in nobenega zvečanja incidence hipoglikemije.
Overall, the CHMP considered that the applicant had responded adequately by providing the results of an additional study, BES No.67289, and had demonstrated formal proof of bioequivalence.
Odbor za zdravila za uporabo v humani medicini (CHMP) je menil, da se je predlagatelj ustrezno odzval z zagotovitvijo rezultatov dodatne študije biološke enakovrednosti št. 67289 in predložil uradni dokaz biološke enakovrednosti zdravil.
Take special care with LISONORM You should check with your doctor before taking this medicine if you: - have heart problems
Bodite posebno pozorni pri uporabi zdravila LISONORM Pred jemanjem tega zdravila se posvetujte z zdravnikom, če: - imate težave s srcem, - imate težave z ledvicami,
Adverse reactions were usually mild, transient and rarely warranted the discontinuation of treatment with Lisonorm .
Neželeni učinki so bili navadno blagi, prehodni in so redko povzročili prekinitev zdravljenja z zdravilom Lisonorm.
Consequently, Lisonorm is contraindicated in pregnancy (see section 4.3).
Zato je zdravilo Lisonorm v nosečnosti kontraindicirano (glejte poglavje 4.3).
Immune system disorders Very rare
Bolezni imunskega sistema Zelo redki
6.4 Special precautions for storage Store below 25°C
6.4 Posebna navodila za shranjevanje Shranjujte pri temperaturi do 25 °C.
• immunosuppressants, used to prevent transplant rejection
• imunosupresivna zdravila, ki se uporabljajo za preprečevanje zavrnitve presadkov,
In addition to its direct blood pressure lowering effect, lisinopril mitigates albuminuria by modifying the haemodynamic conditions and tissue structure in the renal glomeruli.
Poleg njegovega neposrednega učinka zniževanja krvnega tlaka lizinopril ublaži albuminurijo, saj spremeni hemodinamične pogoje in tkivno strukturo v ledvičnih glomerulih.
If the oedematous swelling involves the tongue, glottis or larynx, or it is likely to cause airway obstruction; emergency treatment should be initiated promptly.
Če edematozna oteklina vključuje jezik, glotis ali grlo ali je verjetno, da povzroča obstrukcijo dihal, je treba takoj uvesti nujno zdravljenje.
What Lisonorm is and what it is used for Before you take Lisonorm How to take Lisonorm Possible side effects
Kaj je zdravilo Lisonorm in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Lisonorm Kako jemati zdravilo Lisonorm Možni neželeni učinki
Following oral administration, peak plasma concentrations occur after approximately 6 hours; its bioavailability is 29 %.
Po peroralni uporabi so koncentracije v plazmi največje po približno šestih urah, biološka uporabnost lizinoprila pa je 29-odstotna.
In patients with renal impairment, changes in amlodipine plasma concentrations are not correlated with degree of renal impairment.
Pri bolnikih z ledvično okvaro spremembe koncentracije amlodipina v plazmi niso v korelaciji s stopnjo ledvične okvare.
The 90% confidence intervals calculated for AUC(0-t), AUC(0-inf) and Cmax were within the range of 0.8-1.25 for both components (lisinopril and amlodipine).
90odstotni intervali zaupanja, izračunani za AUC(0-t), AUC(0-nes) in Cmax, so bili za obe sestavini (lizinopril in amlodipin) v okviru 0,8-1,25.
As expected in this type of medicinal product, headache was the most commonly reported adverse event.
Kot je mogoče pričakovati za to vrsto zdravila, je bil najpogosteje prijavljeni neželeni učinek glavobol.
An Article 29 referral procedure was initiated due to concerns raised by the CZ and LV on the potential serious risk to public health regarding insufficient proof of bioequivalence since the Applicant did not use the originator´s products (Aulin Gel) as reference treatments but used monocomponent-containing generics in the originally submitted bioequivalence study.
Napotitveni postopek v skladu s členom 29 sta zaradi zadržkov sprožili CZ in LV zaradi možnega tveganja za javno zdravje na podlagi nezadostnih dokazov o biološki enakovrednosti, saj predlagatelj v prvotno predloženi študiji o biološki enakovrednosti ni uporabil originatornega zdravila (Aulin Gel) kot referenčnega zdravila, ampak je namesto tega uporabil generično zdravilo z eno samo učinkovino (monokomponentno).
Store below 25°C.
Shranjujte pri temperaturi do 25°C!
Tricyclic antidepressants/antipsychotics/anaesthetics/narcotics: Concomitant use with ACE inhibitors may result in further reduction of blood pressure (see section 4.4).
Triciklični antidepresivi/antipsihotiki/anestetiki/narkotiki: Sočasna uporaba z zaviralci ACE lahko povzroči nadaljnje znižanje krvnega tlaka (glejte poglavje 4.4).
• medicines used to treat bacterial (rifampicin), HIV (ritonavir) or fungal infections (ketoconazole).
• zdravila, ki se uporabljajo za zdravljenje bakterijskih okužb (rifampicin), okužb s HIV (ritonavir) in glivičnih okužb (ketokonazol),
• Hereditary or idiopathic angioedema (see section 4.4).
• Dedni ali idiopatični angioedem (glejte poglavje 4.4).
Amlodipine clearance tends to be lower with resulting increase in AUC and elimination half-life in the elderly.
Očistek amlodipina je manjši, kar povzroči povečanje AUC in eliminacijskega razpolovnega časa pri starejših bolnikih.
Amlodipine reduces the tone of smooth muscle in arterioles and hence the peripheral vascular resistance which lowers systemic blood pressure.
Amlodipin zmanjša tonus gladkih mišic v arteriolah, zato se zmanjša periferni vaskularni upor, kar zmanjša sistemski krvni tlak.
Lisinopril (n=68)
Lizinopril (n = 68)
Intestinal angioedema should be included in the differential diagnosis of patients on ACE inhibitors presenting with abdominal pain.
Črevesni angioedem je treba vključiti v diferencialno diagnozo bolnikov, ki jemljejo zaviralci ACE in imajo abdominalno bolečino.
Uncommon Mood altered, Sleep disturbances
Spremenjeno razpoloženje, motnje spanja
• diuretics (used to reduce fluid retention)
• diuretiki (za zmanjševanje zadrževanja tekočine),
During a controlled clinical study (n=195), the incidence of adverse reactions was not higher in subjects receiving both active substances concomitantly than in patients on monotherapy.
Med nadzorovano klinično študijo (n = 195) incidenca neželenih učinkov pri preizkovancih, ki so sočasno prejemali obe zdravilni učinkovini, ni bila večja kot pri preizkovancih na monoterapiji.
10 mg/5 mg tablets oral use
10 mg/5 mg tablete peroralna uporaba
SPECIAL STORAGE CONDITIONS Store below 25 °C.
POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte pri temperaturi do 25 °C!
If you forget to take Lisonorm
Če ste pozabili vzeti zdravilo Lisonorm
CYP3A4 inhibitors: A study in elderly patients has shown that diltiazem inhibits the metabolism of amlodipine, probably via CYP3A4 (plasma concentration increases by approximately 50% and the effect of amlodipine is increased).
Zaviralci CYP3A4: Študija pri starejših bolnikih je pokazala, da diltiazem zavira presnovo amlodipina, verjetno prek encima CYP3A4 (koncentracija v plazmi se zveča za približno 50 %, zveča pa se tudi učinek amlodipina).
The time to reach peak plasma concentrations (tmax) of amlodipine is similar in elderly and younger subjects.
Čas, potreben za doseganje največje koncentracije amlodipina v plazmi, (tmax) je pri starejših in mlajših bolnikih podoben.
Lisonorm is not recommended for breast-feeding mothers, as lisinopril may be excreted in human milk (see section 4.3).
Zdravilo Lisonorm se ne priporoča pri doječih materah, saj se lahko lizinopril izloča v materino mleko (glejte poglavje 4.3).
Patients planning pregnancy Lisonorm should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancy.
Pri bolnicah, ki načrtujejo nosečnost, je treba čim prej preiti na alternativno antihipertenzivno zdravljenje z uveljavljenim varnostnim profilom za uporabo v nosečnosti.
Oedema, Fatigue
Edem, utrujenost
• anticonvulsants (such as carbamazepine, phenobarbital and phenytoin), used to treat epilepsy
• antikonvulzivi (kot so karbamazepin, fenobarbital in fenitoin), ki se uporabljajo za zdravljenje epilepsije,
Pancreatitis, Gastritis, Gingival hyperplasia
Pankreatitis, gastritis, gingivalna hiperplazija
In such cases, Lisonorm should be discontinued immediately and the patient kept under close medical supervision until complete and sustained resolution of symptoms has occurred.
V takih primerih je treba uporabo zdravila Lisonorm takoj prekiniti in bolnika skrbno zdravniško nadzorovati, dokler simptomi popolnoma ne izginejo.
Lisinopril mitigates the kaliuretic effect of diuretics.
Lizinopril ublaži kalijuretične učinke diuretikov.
Other antihypertensives: Concomitant use of these agents may increase the hypotensive effects of Lisonorm .
Drugi antihipertenzivi: Sočasna uporaba teh snovi lahko poveča hipotenzivne učinke zdravila Lisonorm.
Aortic and mitral stenosis, obstructive hypertrophic cardiomyopathy As with all vasodilators, Lisonorm should be administered with caution to patients with obstruction in the outflow tract of the left ventricle and with stenosis of mitral valve.
Aortna in mitralna stenoza, obstrukcijska hipertrofična kardiomiopatija Kot pri vseh vazodilatatorjih je treba zdravilo Lisonorm uporabljati previdno pri bolnikih z obstrukcijo v izhodnem traktu levega prekata in stenozo mitralne zaklopke.
Dyspnoea, Rhinitis
Dispneja, rinitis
Bronchospasm, Allergic alveolitis/Eosinophilic pneumonia, Sinusitis
Bronhospazem, alergijski alveolitis/eozinofilna pnevmonija, sinuzitis
Adverse reactions were consistent with those reported previously with amlodipine and/or lisinopril.
Neželeni učinki so bili skladni s tistimi, o katerih so že prej poročali pri amlodipinu in/ali lizinoprilu.
Impotence, Gynaecomastia
Impotenca, ginekomastija
If hypotension occurs, the patient should be placed in a supine position and intravenous fluid replacement (intravenous infusion of physiologic saline) should be administered if necessary.
Če se pojavi hipotenzija, je treba bolnika položiti v ležeč položaj na hrbet in po potrebi uvesti nadomeščanje z intravensko tekočino (intravensko infundiranje fiziološke raztopine).
No teratogenic effects of lisinopril were seen in mice, rats and rabbits given doses that were 55 times, 33 times and 0.15 times, respectively, the maximum recommended human daily dose.
Pri miših, podganah in zajcih niso opazili nobenih teratogenih učinkov, pri čemer so bili odmerki 55-, 33- oziroma 0,15-krat večji od največjega priporočenega dnevnega odmerka pri človeku.
Fertility was not affected in female and male rats in doses up to 300 mg/kg (33 times the maximum recommended human daily dose when compared on a body surface area).
Pri podganjih samicah in samcih plodnost ni bila prizadeta pri odmerkih do 300 mg/kg (33-kratni največji priporočeni dnevni odmerek pri človeku glede na telesno površino).
Pharmacokinetic parameters were calculated for amlodipine and lisinopril by the means of Bioequiv 3.5 software using a model independent approach.
Za amlodipin in lizinopril so bili z uporabo programske opreme Bioequiv 3.5, ki uporablja od vzorca neodvisen pristop, izračunani farmakokinetični parametri.
Diuretics: When a diuretic is added to the therapy of a patient receiving Lisonorm the antihypertensive effect is usually additive (see section 4.4).
Diuretiki: Kadar se zdravljenju bolnika, ki prejema zdravilo Lisonorm, doda diuretik, se antihipertenzivni učinek navadno poveča (glejte poglavje 4.4).
Characteristically, the cough is nonproductive, persistent and resolves after discontinuation of therapy.
Najpogosteje je neproduktiven, perzistenten in po prenehanju zdravljenja izgine.
In line with the regulatory requirements (CHMP/EWP/191583/2005), a formal proof of bioequivalence, evidence of a wide therapeutic experience, and an adequately established benefit/risk ratio should be demonstrated for new fixed dose combination products claiming substitution indication.
V skladu s pravnimi predpisi (CHMP/EWP/191583/2005) so za nova zdravila s točno določenim odmerkom učinkovin, za katera se zahteva nadomestno indiciranje, potrebni uradni dokaz biološke enakovrednosti, dokaz o obsežnih izkušnjah z zdravljenjem in ustrezno ugotovljeno razmerje med koristmi in tveganji.
The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.
Razdelilna zareza je namenjena delitvi tablete za lažje požiranje in ne delitvi na enaka odmerka.
Amlodipine exerts antianginal effect through the dilation of peripheral arterioles as well as through reduction of cardiac afterload, without resulting in reflex tachycardia, and accordingly, energy consumption and oxygen demand of cardiac muscle decrease.
Antianginozni učinek amlodipina povzročata dilatacija perifernih arteriol in zmanjšanje srčnega bremena, ne da bi se ob tem pojavile refleksna tahikardija in poraba energije ter potreba po kisiku zaradi zmanjšanja srčne mišice.
Lisonorm 10mg/5mg 10 mg/5 mg tablets oral use
Lisonorm 10mg/5mg 10 mg/5 mg tablete peroralna uporaba
Substantial decrease in blood pressure and hence symptomatic hypotension can occur in patients with volume and/or sodium depletion resulting from diuretic therapy, fluid loss of other origin such as excessive diaphoresis, prolonged vomiting and/or diarrhoea (see section 4.2).
Veliko znižanje krvnega tlaka in posledična simptomatska hipotenzija se lahko pojavita pri bolnikih z zmanjšanjem prostornine in/ali znižanjem natrija, ki jo povzročijo zdravljenje z diuretiki, izguba tekočine drugega izvora, kot je čezmerna diaforeza, dolgotrajno bruhanje in/ali driska (glejte poglavje 4.2).
Once daily dosing of amlodipine reduces the blood pressure of hypertensive patients both in the supine and standing position throughout the 24-hour interval.
Odmerjanje amlodipina enkrat na dan zniža krvi tlak bolnikov s hipertenzijo v ležečem in stoječem položaju v štiriindvajseturnem presledku.
Antacids decrease the bioavailability of the concomitant use of ACE inhibitors.
Antacidi zmanjšajo biološko uporabnost sočasno uporabljenih zaviralcev ACE.
Angioedema accompanied by laryngeal oedema is potentially fatal.
Angioedem v kombinaciji z laringealnim edemom je potencialno smrten.
DATE OF REVISION OF THE TEXT [To be completed nationally]
DATUM ZADNJE REVIZIJE BESEDILA [Izpolni država članica.]
Calcium channel blocking activity, for example elicits direct arterial dilation accompanied by sodium and water retention.
Blokiranje kalcijevih kanalčkov na primer sproži neposredno arterijsko dilatacijo, ki jo spremlja retencija natrija in vode.
Amlodipine is slowly and almost completely absorbed from the gastrointestinal tract following oral administration.
Amlodipin se po peroralni uporabi počasi in skoraj popolnoma absorbira iz gastrointestinalnega trakta.
The angioedema was diagnosed by procedures including CT scan, or ultrasound or at surgery and symptoms resolved after stopping the ACE inhibitor.
Angioedem so diagnosticirali s postopki, ki vključujejo slikanje CT ali ultrazvok, ali pri kirurškem posegu, simptomi pa so izginili po prekinitvi uporabe zaviralca ACE.
If a medicinal product that affects potassium levels is to be prescribed in combination with lisinopril, monitoring of potassium serum levels is advised.
Če je treba zdravilo, ki vpliva na raven kalija, predpisati v kombinaciji z lizinoprilom, se priporoča spremljanje ravni kalija v serumu.
Children and adolescents Lisonorm is not recommended for use in children below age 18 due to a lack of data on safety and efficacy.
Zaradi pomanjkanja podatkov o varnosti in učinkovitosti se uporaba zdravila Lisonorm ne priporoča pri otrocih, mlajših od 18 let.
In hyperglycaemic patients, lisinopril contributes to the restoration of impaired endothelial function.
Pri hiperglikemičnih bolnikih lizinopril prispeva k ponovni vzpostavitvi okvarjenega endotelijskega delovanja.
• lithium, antipsychotics, used to treat mental disorders
• litij, antipsihotiki, ki se uporabljajo za zdravljenje duševnih motenj,
This medicinal product is authorised in the Member States of the EEA under the following names: {Name of the Member State} {Name of the medicinal product} [See Annex I - To be completed nationally]
Zdravilo je pridobilo dovoljenje za promet v državah članicah EGP pod naslednjimi imeni: {Ime države članice} {Ime zdravila} [Glejte Dodatek I - Izpolni država članica.]
Insomnia, Mood altered
Nespečnost, spremenjeno razpoloženje
It inhibits the influx of calcium into myocardial and vascular smooth muscle cells through the inhibition of slow calcium ion channels of the cell membranes.
Zavira dotok kalcija v miokardne in vaskularne gladke mišice, saj zavira počasne kanalčke kalcijevih ionov v celičnih membranah.
The geometric mean ratios, 90% confidence intervals and corresponding intra-individual CVs for Cmax, AUC0-t and AUC0-∞ for amlodipine and lisinopril were also presented.
Predstavljeni so bili tudi geometrično povprečno razmerje, 90-odstotni intervali zaupanja in pripadajoči intraindividualni CV-ji za Cmax AUC0-t in AUC0-∞ za amlodipin in lizinopril.
Packs contain 30 tablets in white, opaque PVC/PE/PVDC-aluminium blisters.
Pakiranje vsebuje 30 tablet v belih, neprozornih pretisnih omotih iz PVC/PE/PVDC/aluminija.
• Hypersensitivity to lisinopril or to any other angiotensin converting enzyme (ACE) inhibitor.
• Preobčutljivost za lizinopril ali kateri koli drugi zaviralec angiotenzinske konvertaze (ACE).
Non-steroidal anti-inflammatory drugs (NSAIDs): Chronic administration of NSAIDs, including high-dosed acetylsalicylic acid ≥ 3 g/day, may reduce the antihypertensive effect of an ACE inhibitor.
Nesteroidna protivnetna zdravila: Kronična uporaba nesteroidnih protivnetnih zdravil, vključno z velikim odmerki acetilsalicilne kisline ≥ 3 g/dan, lahko zmanjša antihipertenzivni učinek zaviralca ACE.