natgillin/translations-raw huggingface dataset:
In anaesthetised rabbits, hydroxocobalamin exerted haemodynamic effects (increased mean arterial blood pressure and total peripheral resistance, decreased cardiac output) related to its nitric oxidescavenging property.
Pri anesteziranih kuncih je imel hidroksokobalamin hemodinamične učinke (zvišan povprečni arterijski krvni tlak in skupni periferni upor, zmanjšan srčni iztis), povezane z njegovo lastnostjo odstranjevanja dušikovega oksida.
Interference with burn assessment
Motenje ocenjevanja stopnje opeklin
Simultaneous administration of hydroxocobalamin and blood products (whole blood, packed red cells, platelet concentrate and fresh frozen plasma) through the same intravenous line is not recommended.
Sočasna uporaba hidroksokobalamina in krvnih izdelkov (polne krvi, koncentrata eritrocitov, koncentrata trombocitov in sveže zamrznjene plazme) po isti intravenski liniji ni priporočena.
Because of its deep red colour, hydroxocobalamin has the potential to interfere with determination of laboratory parameters (e.g. clinical chemistry, haematology, coagulation, and urine parameters).
Hidroksokobalamin je temno rdeč, zato lahko moti določanje laboratorijskih parametrov (npr. parametrov klinične kemije, hematologije, koagulacije in urina).
Among 144 patients not in initial cardiac arrest whose outcomes were known, 118 (82%) survived.
Od 144 bolnikov, za katere je izid znan in ki niso imeli srčnega zastoja, jih je preživelo 118 (82%).
The Cyanokit vial is to be rocked or inverted for at least 1 minute to mix the solution.
Vialo z zdravilom Cyanokit je treba zibati ali obračati vsaj 1 minuto, da se raztopina premeša.
Histopathology revealed brain lesions that were consistent with cyanide-induced hypoxia.
Histopatološke preiskave so pokazale možganske lezije, značilne za hipoksijo, ki jo povzroča cianid.
Sodium chloride 9 mg/mL (N=17)
Natrijev klorid 9 mg/ml (N=17)
The 75 mg/kg and 150 mg/kg doses are approximately equivalent to 5 g and 10 g of hydroxocobalamin, respectively, in humans, not only on a body weight basis but also on Cmax basis of hydroxocobalamin [total cobalamins-(III), see section 5.2].
Odmerek 75 mg/kg približno ustreza odmerku 5 g hidroksokobalamina pri človeku, 150 mg/kg pa 10 g hidroksokobalamina, ne le na podlagi telesne mase, ampak tudi na podlagi vrednosti Cmax [skupni kobalamini-(III), glejte poglavje 5.2].
If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 6 hours at 2°C to 8°C.
Če se zdravilo ne uporabi takoj, je za čas in pogoje shranjevanja raztopine pred uporabo odgovoren uporabnik, ti pa normalno ne smejo biti daljši kot 6 ur pri 2 °C do 8 °C.
Because of its deep red color, hydroxocobalamin may cause haemodialysis machines to shut down due to an erroneous detection of a ‘blood leak'.
Zaradi svoje temno rdeče barve lahko hidroksokobalamin povzroči, da se aparature za hemodializo izklopijo zaradi napačne zaznave „iztekanja krvi“.
What Cyanokit is and what it is used for What you need to know before Cyanokit is used How Cyanokit is used
Kaj je zdravilo Cyanokit in za kaj ga uporabljamo Kaj morate vedeti pred uporabo zdravila Cyanokit Kako uporabljati zdravilo Cyanokit Možni neželeni učinki
A total of 347 subjects were exposed to hydroxocobalamin in clinical studies.
V kliničnih študijah so hidroksokobalaminu izpostavili skupaj 347 oseb.
Dose-proportional pharmacokinetics were observed following single dose intravenous administration of 2.5 to 10 g of Cyanokit in healthy volunteers.
Farmakokinetika po intravenski uporabi enkratnega odmerka 2,5 do 10 g zdravila Cyanokit pri zdravih prostovoljcih je bila odvisna od odmerka.
Depending upon the severity of the poisoning and the clinical response, a second dose may be administered
Glede na stopnjo zastrupitve in klinični odziv lahko dajete naslednji odmerek.
The Cyanokit vial is to be rocked or inverted for at least 30 seconds to mix the solution.
Vialo z zdravilom Cyanokit je treba zibati ali obračati vsaj 30 sekund, da se raztopina premeša.
• kidney injuries such as acute kidney impairment and urine crystals.
• poškodbe ledvic, kot je akutna okvara ledvic in kristali v urinu
• Animal pharmacology
• Farmakologija pri živalih
Urine colouration may last up to 35 days after administration of Cyanokit.
Obarvanje urina lahko traja do 35 dni po uporabi zdravila Cyanokit.
Of these 347 subjects, 245 patients had suspected exposure to cyanide at the time of hydroxocobalamin administration.
Med temi 347 osebami je pri 245 bolnikih v času uporabe hidroksokobalamina obstajal sum na izpostavljenost cianidu.
Combination with another cyanide antidote: Chemical incompatibility was observed with sodium thiosulfate and sodium nitrite.
Kombiniranje z drugimi antidoti proti cianidu: Kemijsko inkompatibilnost so opazili pri natrijevem tiosulfatu in natrijevem nitritu.
Treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of seizures.
Pri zdravljenju zastrupitve s cianidom je treba takoj poskrbeti za prehodnost dihalnih poti, ustrezno oksigenacijo in hidracijo, kardiovaskularno podporo in obravnavanje epileptičnih napadov.
Common signs and symptoms of cyanide poisoning include: nausea, vomiting, headache, altered mental status (e.g. confusion, disorientation), chest tightness, dyspnoea, tachypnoea or hyperpnoea (early), bradypnoea or apnoea (late), hypertension (early) or hypotension (late), cardiovascular collapse, seizures or coma, mydriasis, and plasma lactate concentration > 8 mmol/L.
Med pogostimi znaki in simptomi zastrupitve s cianidom so: navzea, bruhanje, glavobol, sprememba duševnega stanja (npr. zmedenost, dezorientiranost), tiščanje v prsnem košu, dispneja, tahipneja ali hiperpneja (zgodaj), bradipneja ali apneja (pozno), hipertenzija (zgodaj) ali hipotenzija (pozno), kardiovaskularni kolaps, epileptični napadi ali koma, midriaza in koncentracija laktata v plazmi > 8 mmol/l.
They will have to take it into account before treating you with Cyanokit.
To bodo upoštevali pred zdravljenjem z zdravilom Cyanokit.
Hydroxocobalamin will lower blood cyanide concentrations.
Hidroksokobalamin zniža koncentracijo cianida v krvi.
Your doctor will recommend you to stop breast-feeding after treatment with Cyanokit.
Zdravnik vam bo priporočil, da po zdravljenju z zdravilom Cyanokit prenehate dojiti.
MEDICAL OR HEALTH CARE PROFESSIONALS EDUCATIONAL STICKER
INFORMATIVNA NALEPKA ZA ZDRAVNIKE ALI ZDRAVSTVENO OSEBJE
The intravenous infusion set provided in the kit must then be used as it includes an appropriate filter and is to be primed with the reconstituted solution.
Uporabiti je treba priložen komplet za intravensko infundiranje, ker vsebuje ustrezen filter, komplet za intravensko infundiranje pa je treba napolniti z rekonstituirano raztopino.
One transfer device.
Ena naprava za prenos.
• transport in the desert (4 days submitted to temperatures ranging from 5 to 60°C) and
• prevoz v puščavi (4 dni izpostavljenosti temperaturam od 5 °C do 60 °C) in
If blood products (whole blood, packed red cells, platelet concentrate and fresh frozen plasma) and hydroxocobalamin are administered simultaneously, use of separate intravenous lines (preferably on contralateral extremities) is recommended.
Če sočasno uporabljate krvne izdelke (polno kri, koncentrat eritrocitov, koncentrat trombocitov in sveže zamrznjeno plazmo) in hidroksokobalamin, je priporočena uporaba ločenih intravenskih linij (po možnosti na nasprotnih okončinah).
Urine colouration may last up to 35 days after administration of Cyanokit (see section 4.4).
Obarvanje urina lahko traja do 35 dni po uporabi zdravila Cyanokit (glejte poglavje 4.4).
Cyanokit may interfere with burn assessment (red coloration of the skin) and laboratory tests and may lead to shut down of haemodialysis machines (see SmPC).”
Zdravilo Cyanokit lahko moti ocenjevanje stopnje opeklin (povzroči rdeče obarvanje kože) in rezultate laboratorijskih preiskav in lahko povzroči, da se aparature za hemodializo izklopijo (glejte povzetek glavnih značilnosti zdravila).”
Cyanide poisoning may be caused by exposure to smoke from household and industrial fires, breathing or swallowing cyanide, or contact with cyanide on skin.
Zastrupitev s cianidom lahko povzroči izpostavljenost dimu pri požarih v gospodinjstvu in industriji, vdihovanje ali zaužitje cianida ali stik s cianidom prek kože.
Each pack contains one vial packed in one cardboard box, one sterile transfer device, one sterile intravenous infusion set and one sterile short catheter for administration to children.
V enem pakiranju je ena viala, pakirana v eno kartonsko škatlo, ena sterilna naprava za prenos, en sterilen komplet za intravensko infundiranje in en sterilen kratek kateter za uporabo pri otrocih.
Each hydroxocobalamin molecule can bind one cyanide ion by substituting the hydroxo ligand linked to the trivalent cobalt ion to form cyanocobalamin.
Vsaka molekula hidroksokobalamina lahko veže en cianidni ion ob substituciji hidrokso-liganda, ki je vezan na trivalentni kobaltov ion, pri čemer nastane cianokobalamin.
However, skin lesions, oedema, and pain are highly suggestive of burns.
Vendar so za opekline zelo značilne kožne lezije, edem in bolečina.
However, hydroxocobalamin because of its deep red colour may interfere with the performance of haemodialysis machines (see section 4.4).
Vendar pa lahko hidroksokobalamin zaradi svoje temno rdeče barve moti delovanje aparatur za hemodializo (glejte poglavje 4.4).
In the absence of data in breast-fed infants, breast-feeding discontinuation is recommended after receiving Cyanokit.
Ker ni na voljo podatkov pri dojenih otrocih, se po uporabi zdravila Cyanokit priporoča prekinitev dojenja.
Physical incompatibility (particle formation) was observed with the mixture of hydroxocobalamin reconstituted solution and the following medicinal products: diazepam, dobutamine, dopamine, fentanyl, nitroglycerin, pentobarbital, phenytoin sodium, propofol and thiopental.
Fizikalno inkompatibilnost (nastanek delcev) so opazili pri mešanju rekonstituirane raztopine hidroksokobalamina in naslednjih zdravil: diazepam, dobutamin, dopamin, fentanil, nitroglicerin, pentobarbital, natrijev fenitoin, propofol in tiopental.
However, if a cyanide blood level determination is planned, it is recommended to draw the blood sample before initiation of treatment with Cyanokit.
Če pa se načrtuje določanje ravni cianida v krvi, je priporočeno odvzeti vzorec krvi pred začetkom zdravljenja z zdravilom Cyanokit.
In cyanide-poisoned patients, hydroxocobalamin is expected to bind cyanide to form cyanocobalamin, which is excreted in the urine.
Pri bolnikih, zastrupljenih s cianidom, je pričakovati, da bo hidroksokobalamin vezal cianid, pri čemer bo nastal cianokobalamin, ki se izloča z urinom.
Smoke inhalation
Vdihavanje dima
• The active substance is hydroxocobalamin.
• Zdravilna učinkovina je hidroksokobalamin.
monitoring of renal function: Cyanokit may lead to kidney failure and urine crystals.
spremljanje delovanja ledvic: zdravilo Cyanokit lahko povzroči odpoved ledvic in kristale v urinu.
• most patients will experience a reversible red colouration of the skin and membranes lining body cavities (mucous membranes) that may last up to 15 days after administration of Cyanokit.
• pri večini bolnikov se bo pojavilo reverzibilno rdeče obarvanje kože in sluznic telesnih votlin, ki lahko traja do 15 dni po uporabi zdravila Cyanokit
The liver and kidney were found to be the major target organs.
Ugotovili so, da sta glavna ciljna organa jetra in ledvice.
Breathing and chest problems
Težave pri dihanju in težave v prsnem košu
If a cyanide blood level determination is planned, it is recommended to draw the blood sample before initiation of treatment with Cyanokit.
Če se načrtuje določanje ravni cianida v krvi, je priporočeno odvzeti vzorec krvi pred začetkom zdravljenja z zdravilom Cyanokit.
• The other ingredient is hydrochloric acid (for pH adjustment).
• Druga sestavina zdravila je klorovodikova kislina (za uravnavanje pH).
Detailed information for your doctor or other health care professional regarding simultaneous administration of Cyanokit with other medicines can be found at the end of this package leaflet (see 'Handling instructions').
Podrobne informacije za zdravnika ali drugo zdravstveno osebje o sočasni uporabi zdravila Cyanokit in drugih zdravil so na koncu tega navodila (glejte »Navodila za ravnanje«).
• irregular heart beat
• neredno bitje srca
The presence and extent of cyanide poisoning are often initially unknown.
Zastrupitev s cianidom je pogosto sprva neopažena, njena stopnja pa neznana.
• freezing/defrosting cycles (15 days submitted to temperatures ranging from -20 to 40°C).
• cikli zamrzovanja/odmrzovanja (15 dni izpostavljenosti temperaturam od -20 °C do 40 °C)
Preparation of Cyanokit
Priprava zdravila Cyanokit
Detailed instructions for your doctor or other health care professional on how to prepare the Cyanokit infusion and how to determine the dose can be found at the end of this package leaflet (see 'Handling instructions').
Podrobne informacije za zdravnika ali drugo zdravstveno osebje o pripravi infuzije zdravila Cyanokit in določanju odmerka so na koncu tega navodila (glejte »Navodila za ravnanje«).
Other medicines and Cyanokit
Druga zdravila in zdravilo Cyanokit
Hydroxocobalamin reduced whole blood cyanide concentrations from about 120 nmol/mL to 30-40 nmol/mL by the end of the infusion compared with 70 nmol/mL in dogs receiving sodium chloride 9 mg/mL alone.
Hidroksokobalamin je ob koncu infundiranja zmanjšal celotno koncentracijo cianida v krvi s približno 120 nmol/ml na 30-40 nmol/ml, pri psih, ki so prejemali samo 9 mg/ml natrijevega klorida, pa je koncentracijo zmanjšal na 70 nmol/ml.
Following intravenous administration of Cyanokit, significant binding to plasma proteins and low molecular weight physiological compounds occurs, to form various cobalamin-(III) complexes by replacing the hydroxo ligand.
Po intravenski uporabi zdravila Cyanokit pride do pomembne vezave na beljakovine v plazmi in pojava fizioloških spojin z majhno molsko maso, ki s substitucijo hidrokso liganda tvorijo različne komplekse kobalamina-(III).
Survival of cyanide-poisoned dogs
Preživetje psov, zastrupljenih s cianidom
Swelling, irritation, redness.
Otekanje, iritacija, rdečica.
• Chromaturia: all patients will show a dark red colouration of the urine quite marked during the first three days following administration.
• Kromaturija: pri vseh bolnikih se bo v prvih treh dneh po uporabi pojavilo znatno temno rdeče obarvanje urina.
Read the leaflet for storage conditions in ambulatory use
Za pogoje shranjevanja pri ambulantni uporabi glejte navodilo za uporabo.
If the decision is made to administer another cyanide antidote with Cyanokit, these medicinal products must not be administered concurrently in the same intravenous line (see section 6.2).
Pri odločitvi za uporabo drugega antidota proti cianidu skupaj z zdravilom Cyanokit, se ta zdravila ne smejo dajati sočasno po isti intravenski liniji (glejte poglavje 6.2).
If the decision is made to administer another cyanide antidote with Cyanokit, these medicinal products must not be administered concurrently in the same intravenous line.
Pri odločitvi za uporabo drugega antidota proti cianidu skupaj z zdravilom Cyanokit, se ta zdravila ne smejo dajati sočasno po isti intravenski liniji.
Observed in vitro interferences of hydroxocobalamin with laboratory tests
Opažene motnje hidroksokobalamina pri laboratorijskih preiskavah in vitro
Pleural effusion, dyspnoea, throat tightness, dry throat, chest discomfort.
Bolezni dihal, prsnega koša in mediastinalnega prostora Plevralni izliv, dispneja, stiskanje v grlu, suho grlo, neprijeten občutek v prsnem košu.
Artificially increased*
Motnja ni opažena Umetno zvišan*
Chemical incompatibility was observed with the mixture of hydroxocobalamin reconstituted solution and the following medicinal products: epinephrine, lidocaine hydrochloride, adenosine, atropine, midazolam, ketamin, succinylcholine chloride, amiodarone hydrochloride, sodium bicarbonate, sodium thiosulfate, sodium nitrite, and has been reported with ascorbic acid.
Kemijsko inkompatibilnost so opazili pri mešanju rekonstituirane raztopine hidroksokobalamina in naslednjih zdravil: epinefrin, lidokainijev klorid, adenozin, atropin, midazolam, ketamin, sukcinilholinijev klorid, amiodaronijev klorid, natrijev hidrogenkarbonat, natrijev tiosulfat, natrijev nitrit, o njej pa so poročali pri askorbinski kislini.
Renal and urinary problems
Težave z ledvicami in urinom
• usual transport (15 days submitted to temperatures ranging from 5 to 40°C)
• običajni prevoz (15 dni izpostavljenosti temperaturam od 5 °C do 40 °C),
What Cyanokit looks like and contents of the pack
Izgled zdravila Cyanokit in vsebina pakiranja
Abdominal discomfort, dyspepsia, diarrhoea, vomiting, nausea, dysphagia.
Neprijeten občutek v trebuhu, dispepsija, diareja, bruhanje, navzea, disfagija.
No special hazard for humans was identified based on conventional studies of single and repeated dose toxicity and genotoxicity.
Običajne študije toksičnosti pri enkratnih in ponavljajočih se odmerkih in genotoksičnosti ne kažejo posebnega tveganja za človeka.
Headache; injection site reaction; peripheral oedema.
Splošne težave in spremembe na mestu aplikacije Glavobol; reakcije na mestu injiciranja; periferni edem.
Mean corpuscular volume (MCV) Leucocytes
Povprečni volumen eritrocitov (MCV) Levkociti
If these temporary conditions have been exceeded, the product should be discarded.
Zdravilo je treba pri prekoračitvi teh začasnih pogojev zavreči.
Cyanokit powder for solution for infusion is a dark red crystalline powder supplied in a glass vial closed with bromobutyl rubber stopper and an aluminium cap with a plastic lid.
Zdravilo Cyanokit prašek za raztopino za infundiranje je temno rdeč kristaliničen prašek, ki je na voljo v stekleni viali, zaprti z zamaškom iz bromobutilne gume in aluminijasto zaporko s plastičnim pokrovom.
Cyanokit is an antidote for the treatment of known or suspected cyanide poisoning in all age ranges.
Zdravilo Cyanokit je protistrup za zdravljenje znane zastrupitve s cianidom ali v primeru suma zastrupitve s cianidom za vse starostne skupine.
Reversible red colouration of the skin and mucous membranes: most patients will experience it up to 15 days after administration of Cyanokit.
Reverzibilno rdeče obarvanje kože in sluznic: pri večini bolnikov se pojavi v do 15 dneh po dajanju zdravila Cyanokit.
* ≥ 10% interference observed on at least one analyser ** Artificially decreased using the diazo method *** Inconsistent results
* ≥ 10 % motnje, opažene pri vsaj enem analizatorju.
Prothrombin time (PT) Quick or INR
Quickov test ali INR
Decrease in the percentage of lymphocytes.
Bolezni krvi in limfatičnega sistema Zmanjšanje odstotka limfocitov.
One intravenous infusion set.
En komplet za intravensko infundiranje.
Monocytes
Monociti
Survival at hour 4 and at day 14 was significantly greater in 75 mg/kg and 150 mg/kg hydroxocobalamin dose groups compared with dogs receiving sodium chloride 9 mg/mL alone:
Preživetje po 4 urah in po 14 dnevu je bilo pri skupinah, ki so prejemale odmerke 75 mg/kg hidroksokobalamina in 150 mg/kg hidroksokobalamina, pomembno večje kot pri psih, ki so prejemali samo 9 mg/ml natrijevega klorida:
All patients will show a dark red colouration of the urine quite marked during the first three days following administration.
Pri vseh bolnikih se bo v prvih treh dneh po uporabi pojavilo znatno temno rdeče obarvanje urina.
Effects on blood cyanide assay
Učinki na preizkus cianida v krvi
The incidence of brain lesions was markedly lower in dogs having received 150 mg/kg hydroxocobalamin than in dogs having received 75 mg/kg hydroxocobalamin or sodium chloride 9 mg/mL.
Pogostnost možganskih lezij je bila pri psih, ki so prejemali 150 mg/kg hidroksokobalamina, znatno manjša kot pri psih, ki so prejemali 75 mg/kg hidroksokobalamina ali 9 mg/ml natrijevega klorida.
Oxalate crystals have been observed in the urine of healthy volunteers given hydroxocobalamin.
V urinu zdravih prostovoljcev, ki so dobili hidroksokobalamin, so opazili oksalatne kristale.
• Cyanide-poisoned patients
• Bolniki, zastrupljeni s cianidom
Because of its deep red colour, hydroxocobalamin has the potential to induce a red colouration of the skin and therefore may interfere with burn assessment.
Hidroksokobalamin je temno rdeč, zato lahko povzroči rdeče obarvanje kože in moti ocenjevanje stopnje opeklin.
Dogs were poisoned by intravenous administration of a lethal dose of potassium cyanide.
Zastrupili so jih z intravenskim odmerjanjem smrtnega odmerka kalijevega cianida.
Cyanide poisoning may result from exposure to smoke from closed space fires, inhalation, ingestion, or dermal exposure.
Zastrupitev s cianidom je lahko posledica izpostavljenosti dimu pri požaru v zaprtem prostoru, vdihavanja, zaužitja ali izpostavljenosti prek kože.
Cyanokit has been administered to this patient.
Ta bolnik je prejel zdravilo Cyanokit.
• fluid in the chest (pleural effusion)
• tekočina v prsnem košu (plevralni izliv)
Initial dose Adults: The initial dose of Cyanokit is 5 g (2 x 100 mL).
Začetni odmerek Odrasli: Začetni odmerek zdravila Cyanokit je 5 g (2 x 100 ml).
The predominant mean half-life of free and total cobalamins-(III) was approximately 26 to 31 hours at the 5 and 10 g dose level.
Pri odmerkih 5 in 10 g je bil prevladujoč povprečni razpolovni čas prostih in skupnih kobalaminov(III) približno 26 do 31 ur.
Administration of hydroxocobalamin was generally associated with a normalisation of blood pressure (systolic blood pressure > 90 mmHg) in 17 of 21 patients (81%) who had low blood pressure (systolic blood pressure > 0 and ≤ 90 mmHg) after exposure to cyanide.
Pri 17 od 21 bolnikov (81%), ki so imeli po izpostavljenosti cianidu nizek krvni tlak (sistolični krvni tlak > 0 in ≤ 90 mmHg), je bila na splošno uporaba hidroksokobalamina povezana z normalizacijo krvnega tlaka (sistolični krvni tlak > 90 mmHg).
Chemical and physical in-use stability of the reconstituted solution with sodium chloride 9 mg/mL (0.9%) has been demonstrated for 6 hours at a temperature between 2°C and 40°C.
Raztopina, rekonstituirana z raztopino natrijevega klorida 9 mg/ml (0,9 %) ostane kemično in fizikalno stabilna 6 ur pri temperaturi od 2 °C do 40 °C.
After reconstitution with 200 mL of diluent, each mL of the reconstituted solution contains 25 mg of hydroxocobalamin.
Po rekonstituciji z 200 ml topila vsebuje en ml rekonstituirane raztopine 25 mg hidroksokobalamina.
Memory impairment; dizziness.
Bolezni živčevja Motnje spomina; omotica.
• symptoms such as headache or dizziness, as they may be due to a rise in blood pressure.
• simptomi, kot so glavobol ali omotica, ker so lahko posledica zvišanja krvnega tlaka; zvišanje krvnega tlaka se pojavlja zlasti ob koncu zdravljenja, krvni tlak pa se navadno vrne na izhodiščno vrednost v nekaj urah
Dogs then received sodium chloride 9 mg/mL, 75 mg/kg or 150 mg/kg hydroxocobalamin, administered intravenously over 7.5 minutes.
Nato so jim v 7,5 minutah intravensko dali 9 mg/ml natrijevega klorida, 75 mg/kg hidroksokobalamina ali 150 mg/kg hidroksokobalamina.
The low molecular weight cobalamins-(III) formed including hydroxocobalamin are termed free cobalamins-(III); the sum of free and protein-bound cobalamins is termed total cobalamins-(III).
Nastali kobalamini-(III) z majhno molsko maso, vključno s hidroksokobalaminom, se imenujejo prosti kobalamini-(III).
Transient, generally asymptomatic, increase in blood pressure may occur in patients receiving hydroxocobalamin.
Pri bolnikih, ki prejemajo hidroksokobalamin, lahko pride do prehodnega, na splošno asimptomatičnega zvišanja krvnega tlaka.
After reconstitution with 100 mL of diluent, each mL of the reconstituted solution contains 25 mg of hydroxocobalamin.
Po rekonstituciji s 100 ml topila vsebuje en ml rekonstituirane raztopine 25 mg hidroksokobalamina.
What Cyanokit contains
Kaj vsebuje zdravilo Cyanokit