natgillin/translations-raw huggingface dataset:
1 See inflammatory gastrointestinal disorders warning in section 4.4
1 Glejte opozorilo o vnetnih gastrointestinalnih motnjah v poglavju 4.4
The potential risk of Sevelamer carbonate Winthrop during human pregnancy is unknown.
Možno tveganje zdravila Sevelamerijev karbonat Winthrop med nosečnostjo pri človeku ni znano.
Most of adverse reactions reported were gastrointestinal in nature.
Večina neželenih učinkov, je bila gastrointestinalne narave.
Increased levels of serum phosphorus can lead to hard deposits in your body called calcification.
Povišane ravni fosforja v serumu lahko povzročijo trde depozite v telesu, kar se imenuje kalcifikacija.
Genzyme Ireland Ltd. IDA Industrial Park Old Kilmeaden Road Waterford
Izdelovalec Genzyme Ireland Ltd. IDA Industrial Park Old Kilmeaden Road Waterford
Each bottle contains 30 tablets or 180 tablets.
Ena plastenka vsebuje 30 tablet ali 180 tablet.
Date of first authorisation: 15 January 2015 Date of latest renewal:
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve: 15. januar 2015
The sachet has to be discarded after 24 hours of opening.
Vrečico je treba zavreči v roku 24 ur po odprtju.
The recommended starting dose of this medicine for adults and elderly is 2.4-4.8g per day equally divided over three meals.
Priporočeni začetni odmerek tega zdravila pri odraslih in pri starejših je 2,4-4,8 g na dan, ki ga enakomerno razdelite med tri obroke.
In rats and dogs, sevelamer reduced absorption of fat soluble vitamins D, E and K (coagulation factors), and folic acid.
Pri podganah in psih je sevelamer zmanjšal absorpcijo v maščobi topnih vitaminov D, E in K (koagulacijski dejavniki) in folne kisline.
For paediatric patients with a <1.2 BSA (m2), the oral suspension should be administered, as tablet formulations were not tested in this population and therefore are not appropriate for this population.
Pediatrični bolniki s telesno površino < 1,2 m2 morajo zdravilo dobiti v peroralni suspenziji, ker tablete v tej populaciji niso preizkušene in zato zanjo niso primerne.
Do not use this medicine after the expiry date stated on the bottle and/or carton after “EXP”.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na steklenici in škatli poleg oznake „EXP“.
o Discard sachets of powder that have been opened for more than 24 hours.
o Vrečice praška, ki so bile odprte več kot 24 ur, zavrzite.
It is unknown whether Sevelamer carbonate Winthrop is excreted in breast milk and may affect your baby.
Ni znano, ali se zdravilo Sevelamerijev karbonat Winthrop izloča v materino mleko in tako morda vpliva na vašega otroka.
Your doctor can rather prescribe sevelamer carbonate powder for oral suspension.
Morda vam bo zdravnik raje predpisal prašek sevelamerijevega karbonata v oralni suspenziji
Sevelamer carbonate should only be given to pregnant women if clearly needed and after a careful risk/benefit analysis has been conducted for both the mother and the foetus.
Sevelamerijev karbonat naj nosečnice uporabljajo le, če ga nujno potrebujejo, in po skrbni presoji razmerja med koristmi in tveganjem za mater in zarodek.
• If you are taking medicines for heart rhythm problems or for epilepsy, you should consult your doctor when taking Sevelamer carbonate Winthrop.
• Če jemljete zdravila zaradi težav s srčnim ritmom ali zaradi epilepsije, se o jemanju zdravila Sevelamerijev karbonat Winthrop posvetujte z zdravnikom.
For children, the powder is preferred, as tablets are not appropriate for this population.
Pri otrocih ima prašek prednost, ker tablete za to populacijo niso primerne.
Paediatric dose based on BSA (m2)
Pediatrično odmerjanje na podlagi telesne površine (m2)
The most serious adverse reactions are hypersensitivity (very rare frequency), intestinal obstruction (not known frequency), ileus/subileus (not known frequency), intestinal perforation (not known frequency), serious inflammatory gastrointestinal disorders associated with the presence of sevelamer crystals (not known frequency).
Najbolj hudi neželeni učinki so preobčutljivost (zelo redki), obstrukcija črevesa (neznana pogostnost), ileus/subileus (neznana pogostnost), perforacija črevesa (neznana pogostnost), resne vnetne gastrointestinalne motnje povezane s prisotnostjo sevelamerijevih kristalov (neznana pogostnost).
Treatment of these patients with Sevelamer carbonate Winthrop should only be initiated after careful benefit/risk assessment.
Zdravljenje takšnih bolnikov z zdravilom Sevelamerijev karbonat Winthrop se sme začeti le po skrbnem pretehtanju koristi in tveganj.
Ciclosporin, mycophenolate mofetil and tacrolimus in transplant patients
Ciklosporin, mikofenolat mofetil in takrolimus pri bolnikih po presaditvi
Crystal deposit intestine1
Preiskave depozit kristalov v črevesu1
The highest dose in this study was 4.5 g/kg/day (human equivalent dose 2 times the maximum clinical trial dose of 13 g/day, based on a comparison of relative BSA).
Najvišji odmerek v tej študiji je bil 4,5 g/kg/dan (primerjalni odmerek pri človeku je dvakrat večji od največjega odmerka v kliničnem preskušanju, ki je 13 g/dan, na osnovi relativne površine telesa).
Each carton contains 90 sachets and a dosing spoon to measure the 0.4 g dose of powder.
Vsaka škatla vsebuje 90 vrečic in odmerno žličko, s katero se odmeri 0,4 g praška.
• The effects of medicines such as ciclosporin, mycophenolate mofetil and tacrolimus (medicines used to suppress the immune system) may be reduced by Sevelamer carbonate Winthrop.
• Učinke zdravil kot so ciklosporin, mikofenolat mofetil in takrolimus (zdravila, ki zavirajo odziv imunskega sistema), lahko zdravilo Sevelamerijev karbonat Winthrop zmanjša.
Stopping Sevelamer carbonate Winthrop would lead to important consequences such as calcification in the blood vessels.
Prenehanje jemanja zdravila Sevelamerijev karbonat Winthrop bi imelo pomembne posledice, na primer kalcifikacije v žilah.
Children/adolescents (>6 years of age and a BSA of >0.75m2) The recommended starting dose of sevelamer carbonate for children is between 2.4 g and 4.8 g per day based on the patient's BSA category.
Otroci/mladostniki (stari > 6 let in s telesno površino > 0,75 m2) Priporočeni začetni odmerek sevelamerijevega karbonata za otroke je od 2,4 g do 4,8 g na dan na podlagi kategorije bolnikove telesne površine.
If you consider stopping your Sevelamer carbonate Winthrop treatment, contact your doctor or pharmacist first.
Če razmišljate o prenehanju jemanja zdravila Sevelamerijev karbonat Winthrop, se najprej posvetujte z zdravnikom ali farmacevtom.
Adverse reactions that occurred during clinical trials or that were spontaneously reported from postmarketing experience are listed by frequency in the table below.
Neželeni učinki ki so se pojavili med kliničnimi študijami in ki so bili spontano poročani med izkušnjami v obdobju trženja so po pogostnosti našteti v spodnji preglednici.
Reduced levels of ciclosporin, mycophenolate mofetil and tacrolimus have been reported in transplant patients when co-administered with sevelamer hydrochloride without any clinical consequences (e.g., graft rejection).
Pri bolnikih po presaditvi so poročali o znižanih ravneh ciklosporina, mikofenolat mofetila in takrolimusa pri sočasnem dajanju s sevelamerijevim kloridom, kar pa ni imelo kliničnih posledic (npr. zavrnitve presadka).
- The other ingredients are microcrystalline cellulose, sodium chloride, zinc stearate, hypromellose (E464), diacetylated monoglycerides, iron oxide black (E172), isopropyl alcohol, propylene glycol and hypromellose (E464).
- Pomožne snovi so mikrokristalna celuloza, natrijev klorid, cinkov stearat, hipromeloza (E464), diacetilirani monogliceridi, črn železov oksid (E172), izopropil alkohol, propilenglikol in hipromelozo (E464).
Sevelamer carbonate Winthrop film-coated tablets are white to off-white tablets with SC800 imprinted on one side.
Sevelamerijev karbonat Winthrop filmsko obložene tablete so bele do skoraj bele tablete z natisom SC800 vtisnjenim na eni strani.
PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON - CARTON OF 60 or 90 SACHETS
PODATKI NA ZUNANJI OVOJNINI ŠKATLA - ŠKATLA S 60 ALI 90 VREČICAMI
Consequently, sevelamer carbonate should not be taken simultaneously with ciprofloxacin.
Zato se sevelamerijev karbonat ne sme jemati istočasno s ciprofloksacinom.
• if you have active inflammation of the bowel
• če imate aktivno vnetje črevesa
What Sevelamer carbonate Winthrop is and what it is used for 2.
Kaj je zdravilo Sevelamerijev karbonat Winthrop in za kaj ga uporabljamo 2.
• cases of itching,
• primeri srbečice,
Take Sevelamer carbonate Winthrop after your meal or with food.
Zdravilo Sevelamerijev karbonat Winthrop vzemite po obroku ali s hrano.
Sanofi-Aventis Deutschland GmbH
Deutschland Sanofi-Aventis Deutschland GmbH
• Sevelamer carbonate Winthrop should not be taken at the same time as ciprofloxacin (an antibiotic).
• Zdravila Sevelamerijev karbonat Winthrop ne smete jemati sočasno s ciprofloksacinom (antibiotik).
• if you have problems with motility (movement) in your stomach and bowel
• če imate težave z motiliteto (giblivostjo) trebuha in črevesa
The safety of sevelamer (as either carbonate and hydrochloride salts) has been investigated in numerous clinical trials involving a total of 969 haemodialysis patients with treatment duration of 4 to 50 weeks (724 patients treated with sevelamer hydrochloride and 245 with sevelamer carbonate), 97 peritoneal dialysis patients with treatment duration of 12 weeks (all treated with sevelamer hydrochloride) and 128 patients with CKD not on dialysis with treatment duration of 8 to 12 weeks (79 patients treatment with sevelamer hydrochloride and 49 with sevelamer carbonate).
Varnost sevelamera (bodisi kot karbonata in kloridne soli) je bila raziskana v številnih kliničnih preskušanjih, ki so zajela skupaj 969 bolnikov na hemodializi, pri katerih je zdravljenje trajalo med 4 do 50 tednov (724 bolnikov, zdravljenih s sevelamerijevim kloridom in 245 s sevelamerijevim karbonatom), 97 bolnikov na peritonealni dializi, pri katerih je zdravljenje trajalo 12 tednov (vsi zdravljeni s sevelamerijevim kloridom) in 128 bolnikih s KBL, ki niso na dializi, pri katerih je zdravljenje trajalo med 8 do 12 tednov (79 bolnikov, zdravljenih s sevelamerijevim kloridom, in 49 s sevelamerijevim karbonatom).
Each sachet of 2.4 g of powder is to be dispersed in 60 ml of water prior to administration (see section 6.6).
Vsako vrečico po 2,4 g praška je treba pred uporabo raztopiti v 60 ml vode (glejte poglavje 6.6).
Sevelamer carbonate Winthrop powder should not be heated (e.g. microwave) or added to heated foods or liquids.
Praška zdravila Sevelamerijev karbonat Winthrop naj se ne segreva (npr. mikrovalovna pečica) ali dodaja v ogreto hrano ali tekočino.
The most frequently occurring (≥5% of patients) adverse reactions were all in the gastrointestinal disorders system organ class: nausea (very common), vomiting (very common), upper abdominal pain (very common), constipation (very common), diarrhea (common), dyspepsia (common) and flatulence (common).
Najpogostejši neželeni učinki (≥ 5 % bolnikov) so bili vsi v organskem sistemu bolezni prebavil: navzea (zelo pogosti), bruhanje (zelo pogosti), bolečine v zgornjem delu trebuha (zelo pogosti), zaprtost (zelo pogosti), diareja (pogosti), dispepsija (pogosti) in flatulenca (pogosti).
• Medicines treating heartburn and reflux from your stomach or oesophagus, such as omeprazole, pantoprazole, or lansoprazole, known as “proton pump inhibitors”, may reduce the efficacy of Sevelamer carbonate Winthrop.
• Zdravila za zdravljenje zgage in vračanja kisline (refluksa) iz želodca ali požiralnika, ki jih imenujemo "zaviralci protonske črpalke" in med katere spadajo na primer omeprazol, pantoprazol in lansoprazol, lahko zmanjšajo učinkovitost zdravila Sevelamerijev karbonat Winthrop.
The recommended starting dose of Sevelamer carbonate Winthrop for children is based on their height and weight (used to calculate body surface area by your physician).
Priporočeni začetni odmerek zdravila Sevelamerijev karbonat Winthrop za otroke temelji na njihovi telesni višini in telesni masi (ta dva podatka zdravnik uporabi za izračun telesne površine).
Sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, has been given to normal healthy volunteers in doses of up to 14 grams per day for eight days with no adverse reactions.
Sevelamerijev klorid, ki vsebuje enako učinkovino kot sevelamerijev karbonat, so dajali zdravim prostovoljcem v odmerkih do 14 gramov na dan za osem dni brez pojava neželenih učinkov.
• major gastrointestinal tract surgery
• velika operacija gastrointestinalnega trakta
Deficits in skeletal ossification were observed in several locations in foetuses of female rats dosed with sevelamer at intermediate and high doses (human equivalent dose less than the maximum clinical trial dose of 14.4 g).
Primanjkljaje skeletalne osifikacije so opazili na več mestih pri fetusu podganjih samic s srednjimi in visokimi odmerki sevelamera (primerjalni odmerek pri človeku je manj kot je največji odmerek v kliničnem preskušanju, ki je 14,4 g).
Do not heat Sevelamer carbonate Winthrop powder (e.g. microwave) or add to hot foods or liquids.
Praška zdravila Sevelamerijev karbonat Winthrop ne segrevajte (npr. mikrovalovna pečica) ali dodajte v vročo hrano ali tekočino.
Studies in animals have shown that sevelamer did not impair fertility in male or female rats at exposures at a human equivalent dose 2 times the maximum clinical trial dose of 13 g/day, based on a comparison of relative BSA.
Študije na živalih so pokazale, da sevelamer ne vpliva na plodnost pri samcih in samičkah podgan pri izpostavljenosti primerjalnemu odmerku pri človeku, dvakrat večjemu od največjega odmerka pri kliničnem preskušanju 13 g/dan, na osnovi relativne površine telesa.
In some cases where Sevelamer carbonate Winthrop should be taken at the same time as another medicine, your doctor may advise you to take this medicine 1 hour before or 3 hours after Sevelamer carbonate Winthrop intake.
V nekaterih primerih, ko je treba zdravilo Sevelamerijev karbonat Winthrop vzeti sočasno z drugim zdravilom, vam bo zdravnik morda svetoval, da vzamete drugo zdravilo 1 uro pred ali 3 ure po vnosu zdravila Sevelamer carbonate Winthrop.
180 film-coated tablets
FARMACEVTSKA OBLIKA IN VSEBINA 180 filmsko obloženih tablet
Patients with CKD may develop hypocalcaemia or hypercalcaemia.
Pri bolnikih s KBL lahko pride do hipokalcemije ali hiperkalcemije..
Constipation can be an early symptom of serious gastrointestinal adverse reactions.
Zaprtost je lahko zgodnji znak hudih neželenih učinkov v prebavilih.
Sevelamer carbonate Winthrop is unlikely to affect your ability to drive or to use machines.
Ni verjetno, da bi zdravilo Sevelamerijev karbonat Winthrop vplivalo na vašo sposobnost vožnje in upravljanja strojev.
Initially, your doctor will check the levels of phosphorus in your blood every 2-4 weeks and may adjust the dose of Sevelamer carbonate Winthrop when necessary to reach an adequate phosphate level.
Vaš zdravnik bo na začetku zdravljenja vsake 2 - 4 tedne preverjal ravni fosforja v vaši krvi in po potrebi prilagodil odmerek zdravila Sevelamer carbonate Winthrop, če bo to treba zaradi doseganja ustrezne ravni fosfata.
• if you have swallowing problems.
• če imate težave s požiranjem.
(Instructions for presentation with dosing spoon) The sachet has to be discarded after 24 hours of opening
(Navodila za obliko z odmerno žličko) Zavrzite vrečico v roku 24 ur po odprtju.
In pregnant rabbits given oral doses of sevelamer hydrochloride by gavage during organogenesis, an increase of early resorptions occurred in the high-dose group (human equivalent dose twice the maximum clinical trial dose).
Pri brejih kunčjih samicah, ki so dobivale peroralne odmerke sevelamerijevega klorida z gavažo v času organogeneze, je prišlo do zgodnje resorpcije v skupini, ki je dobivala visoke odmerke (primerjalni odmerek pri človeku je dvakrat večji od največjega odmerka v kliničnem preskušanju).
• severe gastrointestinal motility disorders including untreated or severe gastroparesis, retention of gastric contents and abnormal or irregular bowel motion
• hude motnje gastrointestinalnega gibanja vključno z nezdravljeno ali hudo gastroparezo, zadrževanjem vsebine v želodcu in nenormalnim ali nerednim gibanjem črevesa
Cases of serious inflammatory disorders of different parts of the gastrointestinal tract (including serious complications such as haemorrhage, perforation, ulceration, necrosis, colitis and colonic/caecal mass) associated with the presence of sevelamer crystals have been reported (see section 4.8).
V literaturi so bili opisani primeri resnih vnetnih bolezni različnih delov prebavil (vključno z resnimi zapleti, kot so npr. krvavitev, perforacija, ulceracija, nekroza, kolitis in masa v debelem črevesu/cekuumu), povezanih s prisotnostjo kristalov sevelamerja (glejte poglavje 4.8).
• Hypophosphataemia.
• hipofosfatemija
Each film-coated tablet contains 800 mg of sevelamer carbonate.
Vsaka filmsko obložena tableta vsebuje 800 mg sevelamerijevega karbonata.
This medicine does not require any special storage conditions.
To zdravilo ne potrebuje posebnih pogojev shranjevanja.
What Sevelamer carbonate Winthrop is and what it is used for
Kaj je zdravilo Sevelamerijev karbonat Winthrop in za kaj ga uporabljamo
For patients previously on phosphate binders (sevelamer hydrochloride or calcium based), Sevelamer carbonate Winthrop should be given on a gram for gram basis with monitoring of serum phosphorus levels to ensure optimal daily doses.
Bolnikom, ki so prej uživali vezalce fosforja (sevelamerijev klorid ali kalcijev sevelamerat), je treba zdravilo Sevelamerijev karbonat Winthrop dajati na osnovi gram po gram ter pri tem nadzirati ravni fosforja v serumu, da se zagotovijo optimalni dnevni odmerki.
The treatment response during the 2-week FDP was not affected by BSA, in contrast however, no treatment response was observed in pediatric patients with qualifying phosphorus levels <7.0 mg/dL.
Telesna površina ni vplivala na odziv na zdravljenje med 2-tedenskim UFO, niso pa opazili nobenega odziva pri pediatričnih bolnikih s kvalifikacijsko koncentracijo fosforja < 7,0 mg/dl.
Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.
Zdravilo Sevelamerijev karbonat Winthrop je indicirano za nadzor hiperfosfatemije pri odraslih bolnikih, ki prejemajo hemodializo ali peritonealno dializo.
In case of constipation, please inform your doctor or pharmacist if you experience it.
V primeru zaprtosti o tem obvestite svojega zdravnika ali farmacevta.
Sevelamer hydrochloride did not impair the fertility of male or female rats in a dietary administration study in which the females were treated from 14 days prior to mating through gestation and the males were treated for 28 days prior to mating.
Sevelamerijev klorid ni okvaril sposobnosti razmnoževanja podganjih samcev ali samic v študiji z dietnim odmerjanjem, v kateri so bile samice obravnavane 14 dni pred parjenjem in ves čas brejosti, samci pa 28 dni pred parjenjem.
In two randomised, cross over clinical trials, sevelamer carbonate has been shown to be therapeutically equivalent to sevelamer hydrochloride and therefore effective in controlling serum phosphorus in CKD patients on haemodialysis.
V dveh randomiziranih, navzkrižnih kliničnih študijah se je sevelamerijev karbonat pokazal kot terapevtsko enakovreden s sevelamerijevim kloridom in zato učinkovit pri nadziranju fosforja v serumu pri bolnikih s KBL na hemodializi.
Your doctor will check for interactions between Sevelamer carbonate Winthrop and other medicines on a regular basis.
Sevelamerijev karbonat Winthrop Zdravnik bo redno preverjal medsebojno delovanje zdravila Sevelamerijev karbonat Winthrop in ostalih zdravil.
Constipation is a very common side effect.
Zaprtost je zelo pogosti neželeni učinek.
These symptoms can be due to serious inflammatory bowel disease caused by sevelamer crystal deposit in your bowel.
Ti simptomi so lahko posledica odlaganja kristalov sevelamerja v črevesju.
There was no increased incidence of tumors observed in mice (human equivalent dose 3 times the maximum clinical trial dose).
Pri miših niso opazili povečanja pojavnosti tumorjev (primerjalni odmerek pri človeku 3-krat večji od največjega odmerka v kliničnem preskušanju).
In this case the 0.4 g dose of Sevelamer Carbonate Winthrop powder must be measured using the dosing spoon provided in the carton.
V tem primeru je treba 0,4 g odmerek zdravila Sevelamerijev karbonat Winthrop odmeriti z odmerno žličko, ki se nahaja v škatli.
In two randomised, cross over clinical trials, sevelamer carbonate in both tablet and powder formulations when administered three times per day has been shown to be therapeutically equivalent to sevelamer hydrochloride and therefore effective in controlling serum phosphorus in CKD patients on haemodialysis.
V dveh randomiziranih, navzkrižnih kliničnih študijah se je pri bolnikih, ki so dobivali sevelamerijev karbonat v obliki tablete in praška trikrat na dan, pokazal kot terapevtsko enakovreden s sevelamerijevim kloridom in zato učinkovit pri nadziranju fosforja v serumu pri bolnikih s KBL na hemodializi.
What Sevelamer carbonate Winthrop looks like and contents of the pack
Izgled zdravila Sevelamerijev karbonat Winthrop in vsebina pakiranja
Talk to your doctor who will decide if you can continue the treatment with Sevelamer carbonate Winthrop.
Posvetujte se s svojim zdravnikom, ki bo presodil, ali lahko nadaljujete zdravljenje z zdravilom Sevelamer carbonate Winthrop.
The tablets are packed in high density polyethylene bottles with a child-resistant polypropylene closure and an induction seal.
Tablete so pakirane v polietilenske plastenke visoke gostote z za otroke varnim polipropilenskim pokrovom in induktivno zvarjeno zaporko.
To achieve the correct dose when the sachet has to be divided, please use the dedicated presentation of 0.8 g powder with dosing spoon.
Za dosego ustreznega odmerka, ko je treba vrečico razdeliti, prosimo uporabite temu namenjeno 0,8 g obliko praška z odmerno žličko.
Taking your Sevelamer carbonate Winthrop treatment is important to maintain an appropriate phosphate level in your blood.
Če ste prenehali jemati zdravilo Sevelamerijev karbonat Winthrop Jemanje zdravila Sevelamerijev karbonat Winthrop je pomembno za vzdrževanje ustrezne koncentracije fosfata v krvi.
Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in paediatric patients (>6 years of age and a body surface area (BSA) of >0.75 m2) with chronic kidney disease.
Zdravilo Sevelamerijev karbonat Winthrop je indicirano za obvladovanje hiperfosfatemije pri pediatričnih bolnikih (starih > 6 let in s telesno površino > 0,75 m2) s kronično boleznijo ledvic.
Sevelamer carbonate Winthrop powder for oral suspension is a pale yellow powder supplied in a foil sachet with a heat seal.
Sevelamerijev karbonat Winthrop prašek za peroralno suspenzijo je svetlorumeni prašek, na voljo v termično zvarjeni vrečici iz folije.
Sevelamer carbonate Winthrop must be taken three times per day with meals or snacks.
Zdravilo Sevelamerijev karbonat Winthrop je treba jemati trikrat na dan z obroki ali prigrizki.
• if you have undergone major surgery on your stomach or bowel.
• če ste imeli veliko operacijo trebuha ali črevesa.
Sevelamer carbonate treatment should be reevaluated in patients who develop severe constipation or other severe gastrointestinal symptoms.
Zdravljenje z zdravilom Sevelamerijev karbonat Winthrop je treba znova oceniti pri bolnikih, ki se jim pojavijo huda zaprtost ali kakšni drugi hudi gastrointestinalni simptomi.
Sevelamer carbonate Winthrop must be taken three times per day with meals.
Zdravilo Sevelamerijev karbonat Winthrop je treba jemati trikrat dnevno z obroki.
The anti-arrhythmic medical product should be taken at least one hour before or three hours after Sevelamer carbonate Winthrop, and blood monitoring can be considered.
Antiaritmik mora bolnik vzeti vsaj eno uro pred zdravilom Sevelamerijev karbonat Winthrop ali tri ure po njem; lahko se razmisli o pregledih krvi.