natgillin/translations-raw huggingface dataset:
Do not take Atacand Plus if: you are allergic (hypersensitive) to candesartan cilexetil or hydrochlorothiazide or any of the other ingredients of Atacand Plus (see section 6).
Ne jemljite zdravila Atacand Plus: - če ste alergični (preobčutljivi) na cileksetilkandesartanat ali hidroklorotiazid ali na katerokoli sestavino zdravila Atacand Plus (glejte poglavje 6).
Hydrochlorothiazide is excreted in human milk in small amounts.
Hidroklorotiazid se pri človeku izloča v materinem mleku v majhni količini.
There is no indication of serious or exaggerated first dose hypotension or rebound effect after cessation of treatment.
Ni znakov, da bi se po prvem odmerku pojavila resna ali čezmerna hipotenzija, ali da bi se po prenehanju zdravljenja pojavil povratni učinek ("rebound").
It helps your body to get rid of water and salts like sodium in your urine.
Telesu pomaga z urinom izločiti vodo in soli, kot je natrij.
Calcium or Vitamin D supplements.
• Dodatke kalcija ali vitamina D.
Patients received candesartan or placebo with other antihypertensive treatment added as needed.
Bolniki so prejemali kandesartan ali placebo ter so jim dodali druge antihipertenzive, kot je bilo potrebno.
Very rare Renal impairment, including renal failure in susceptible patients (see section 4.4)
Bolezni sečil zelo redki okvara ledvic, vključno z odpovedjo ledvic pri občutljivih bolnikih (glejte poglavje 4.4)
Worsening of existing lupus erythaematosus-like reactions or appearance of unusual skin reactions.
• Poslabšanje obstoječih, eritematoznemu lupusu podobnih reakcij ali pojav nenavadnih kožnih reakcij.
During long-term therapy, reduced peripheral resistance contributes to the blood pressure reduction.
Med dolgotrajnim zdravljenjem zmanjšanje perifernega upora pripomore k znižanju krvnega tlaka.
If calcium supplements or Vitamin D must be prescribed, serum calcium levels should be monitored and the dose adjusted accordingly.
Če je treba predpisati dodatke kalcija ali vitamin D, je treba koncentracijo kalcija v serumu kontrolirati in odmerek ustrezno prilagoditi.
Angiotensin II is the primary vasoactive hormone of the renin-angiotensin-aldosterone system and plays a role in the pathophysiology of hypertension and other cardiovascular disorders.
Angiotenzin II je primarni vazoaktivni hormon sistema renin-angiotenzin-aldosteron in ima vlogo v patofiziologiji hipertenzije in drugih kardiovaskularnih bolezni.
Atacand Plus may cause increased sensitivity of the skin to sun.
Zdravilo Atacand Plus lahko poveča občutljivost kože za sonce.
Atacand Plus can affect the way some other medicines work and some medicines can have an effect on Atacand Plus.
Zdravilo Atacand Plus lahko vpliva na delovanje nekaterih drugih zdravil in nekatera druga zdravila lahko vplivajo na zdravilo Atacand Plus.
There were 26.7 events per 1000 patient-years in the candesartan group versus 30.0 events per 1000 patientyears in the control group (relative risk 0.89, 95% CI 0.75 to 1.06, p=0.19).
V skupini s kandesartanom so zabeležili 26,7 dogodka na 1000 bolnik-let, v kontrolni skupini pa 30,0 dogodkov na 1000 bolnik-let (relativno tveganje 0,89, 95 % IZ 0,75-1,06, p = 0,19).
Water tablets (diuretics).
• Tablete za odvajanje vode (diuretike).
At the doses contained in Atacand Plus, only minimal effects were observed.
Med uporabo odmerkov, ki jih vsebuje zdravilo Atacand Plus, so opažali le minimalne učinke.
Whilst there is no controlled epidemiological data on the risk with AIIRAs, similar risks may exist for this class of drugs.
O tveganju z ARAII ni kontroliranih epidemioloških podatkov, vendar lahko s to skupino zdravil obstajajo podobna tveganja.
A reduction in your red or white blood cells or platelets.
• Zmanjšanje števila rdečih ali belih krvnih celic ali trombocitov.
Withdrawals from treatment due to adverse events were similar with candesartan cilexetil/hydrochlorothiazide (2.3-3.3%) and placebo (2.7-4.3%).
Delež umikov zaradi neželenih učinkov je bil s cileksetilkandesartanatom/hidroklorotiazidom (2,3-3,3 %) in placebom (2,7-4,3 %) podoben.
Atacand Plus once daily provides effective and smooth blood pressure reduction over 24 hours, with little difference between maximum and trough effects during the dosing interval.
Zdravilo Atacand Plus enkrat na dan zagotavlja učinkovito in enakomerno 24-urno znižanje krvnega tlaka z majhno razliko med največjim in najmanjšim učinkom med odmernim intervalom.
However, the blood pressure response and the incidence of adverse events are similar after a given dose of Atacand Plus in young and elderly patients (see section 4.2).
Toda odziv krvnega tlaka in incidenca neželenih učinkov sta po določenem odmerku zdravila Atacand Plus pri mladih in starejših bolnikih podobna (glejte poglavje
If re-administration of treatment is essential, it is recommended to protect areas exposed to the sun or to artificial UVA radiation.
Če se izkaže, da je ponovna uporaba zdravila nujna, je priporočljivo zaščititi predele, izpostavljene soncu ali umetni svetlobi UVA.
Your doctor will normally advise you to stop taking Atacand Plus before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Atacand Plus.
Zdravnik vam bo praviloma svetoval, da nehajte jemati zdravilo Atacand Plus, preden zanosite ali čim ugotovite, da ste noseči, in vam bo namesto zdravila Atacand Plus predpisal neko drugo zdravilo.
An increased or reduced amount of potassium in your blood, especially if you already have kidney problems or heart failure.
Zvišanje ali znižanje kalija v krvi, zlasti če že imate težave z ledvicami ali srčno popuščanje.
you have persistently high levels of calcium in your blood.
- če imate trajno visok kalcij v krvi.
Back pain, pain in joints and muscles.
• Bolečine v hrbtu, bolečine v sklepih in mišicah.
you are vomiting, have recently had severe vomiting, or have diarrhoea.
- če bruhate, ste pred kratkim močno bruhali ali imate drisko.
The main manifestation of an overdose of hydrochlorothiazide is acute loss of fluid and electrolytes.
Glavni znak prevelikega odmerjanja hidroklorotiazida je akutna izguba tekočine in elektrolitov.
Since there is no effect on the degradation of kinins, or on the metabolism of other substances, such as substance P, AIIRAs are unlikely to be associated with cough.
Ker ARAII ne vplivajo na razgradnjo kininov ali na presnovo drugih snovi, npr. snovi P, ni verjetno, da bi jih spremljal kašelj.
It is not known to what extent hydrochlorothiazide is removed by haemodialysis.
Ni znano, v kolikšni meri hemodializa odstrani hidroklorotiazid.
The usual dose of Atacand Plus is one tablet once a day Swallow the tablet with a drink of water.
Običajen odmerek zdravila Atacand Plus je ena tableta enkrat na dan. Tableto zaužijte s kozarcem vode.
Like all medicines, Atacand Plus can cause side effects, although not everybody gets them.
Kot vsa zdravila ima lahko tudi zdravilo Atacand Plus neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
you have heart, liver or kidney problems.
- če imate težave s srcem, jetri ali ledvicami.
WHAT ATACAND PLUS IS AND WHAT IT IS USED FOR
KAJ JE ZDRAVILO ATACAND PLUS IN ZA KAJ GA UPORABLJAMO
Total plasma clearance of candesartan is about 0.37 ml/min/kg, with a renal clearance of about 0.19 ml/min/kg.
Celotni plazemski očistek kandesartana je približno 0,37 ml/min/kg, njegov ledvični očistek pa je približno 0,19 ml/min/kg.
The addition of hydrochlorothiazide did not significantly affect the outcome of foetal development studies in rats, mice or rabbits (see section 4.6).
Dodatek hidroklorotiazida ni bistveno vplival na izid v študijah razvoja plodov pri podganah, miših ali kuncih (glejte poglavje
• Hydrochlorothiazide belongs to a group of medicines called diuretics (water tablets).
• Hidroklorotiazid spada v skupino zdravil, imenovanih diuretiki (tablete za odvajanje vode).
It is important to keep taking Atacand Plus every day.
Pomembno je, da zdravilo Atacand Plus vzamete vsak dan.
Postural hypotension may become aggravated by simultaneous intake of alcohol, barbiturates or anaesthetics.
Posturalno hipotenzijo lahko poslabša sočasno uživanje alkohola ali barbituratov ali uporaba anestetikov.
Hydrochlorothiazide may increase the risk of acute renal insufficiency especially with high doses of iodinated contrast media.
Hidroklorotiazid lahko poveča tveganje akutne insuficience ledvic, zlasti ob velikih odmerkih kontrastnih sredstev z jodom.
Angiotensin II Receptor Antagonists (AIIRAs):
Antagonisti receptorjev angiotenzina II (ARAII):
This medicinal product does not require any special temperature storage conditions.
• Za shranjevanje zdravila niso potrebna posebna navodila glede temperature.
Therefore, the use of Atacand Plus is not recommended until this condition has been corrected.
Zato zdravila Atacand Plus ni priporočljivo uporabiti, dokler se to stanje ne odpravi.
Based on in vitro data, no interaction would be expected to occur in vivo with medicinal products whose metabolism is dependent upon cytochrome P450 isoenzymes CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 or CYP3A4.
Glede na podatke in vitro ni pričakovati medsebojnega delovanja in vivo z zdravili, katerih presnova je odvisna od izoencimov CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 ali CYP3A4 citokroma P450.
The pharmacokinetics in patients undergoing haemodialysis were similar to those in patients with severe renal impairment.
Farmakokinetika pri bolnikih na hemodializi je bila podobna k bolnikih s hudo okvaro ledvic.
If you are going to have an operation, tell your doctor or dentist that you are taking Atacand Plus.
Če imate predvideno kakšno operacijo oz. poseg, morate zdravniku ali zobozdravniku povedati, da jemljete zdravilo Atacand Plus.
After administration of a single dose of Atacand Plus, onset of the antihypertensive effect generally occurs within 2 hours.
Po uporabi enkratnega odmerka zdravila Atacand Plus se antihipertenzivni učinek praviloma začne v 2 urah.
Amantadine (for the treatment of Parkinson's disease or for serious infections caused by viruses).
• Amantadin (za zdravljenje Parkinsonove bolezni ali resnih virusnih okužb).
you are more than 3 months pregnant (it is also better to avoid Atacand Plus in early pregnancy - see pregnancy section).
- če ste noseči več kot 3 mesece (zdravilu Atacand Plus se je bolje izogniti tudi v zgodnji nosečnosti - glejte poglavje o nosečnosti).
An increased amount of cholesterol, sugar or uric acid in your blood.
Zvišanje holesterola, sladkorja ali sečne kisline v krvi.
Atacand Plus and associated names (see Annex I) 8 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 16 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 32 mg/12.5 mg tablets Atacand Plus and associated names (see Annex I) 32 mg/25 mg tablets
Atacand Plus in z njim povezana imena (glejte Dodatek I) 8 mg/12,5 mg tablete Atacand Plus in z njim povezana imena (glejte Dodatek I) 16 mg/12,5 mg tablete Atacand Plus in z njim povezana imena (glejte Dodatek I) 32 mg/12,5 mg tablete Atacand Plus in z njim povezana imena (glejte Dodatek I) 32 mg/25 mg tablete
Hydrochlorothiazide inhibits the active reabsorption of sodium, mainly in the distal kidney tubules, and promotes the excretion of sodium, chloride and water.
Hidroklorotiazid zavira aktivno reabsorpcijo natrija, predvsem v distalnih ledvičnih tubulih, in spodbuja izločanje natrija, klorida in vode.
Candesartan cilexetil/hydrochlorothiazide is similarly effective in patients irrespective of age and gender.
Kombinacija cileksetilkandesartanat/hidroklorotiazid je pri bolnikih podobno učinkovita ne glede na starost in spol.
In double-blind, randomised studies, the incidence of adverse events, especially cough, was lower during treatment with Atacand Plus than during treatment with combinations of ACE inhibitors and hydrochlorothiazide.
V dvojno slepih, randomiziranih študijah je bila incidenca neželenih učinkov, zlasti kašlja, manjša med zdravljenjem z zdravilom Atacand Plus kot med zdravljenjem s kombinacijami zaviralcev ACE in hidroklorotiazida.
There were no qualitative new toxic findings with the combination compared to that observed for each component.
Med uporabo kombinacije ni bilo kvalitativno novih izsledkov glede toksičnosti v primerjavi z uporabo vsake posamezne sestavine.
Therefore the use of Atacand Plus is not recommended in this population.
Zato uporaba zdravila Atacand Plus v tej populaciji ni priporočljiva.
Jaundice (yellowing of the skin or the whites of your eyes).
• Zlatenica (porumenelost kože ali očesnih beločnic).
Potassium supplements or salt substitutes containing potassium (medicines that increase the amount of potassium in your blood).
• Dodatke kalija ali nadomestke soli, ki vsebujejo kalij (zdravila, ki povečujejo količino kalija v krvi).
As with any antihypertensive agent, excessive blood pressure decrease in patients with ischaemic heart disease or atherosclerotic cerebrovascular disease could result in a myocardial infarction or stroke.
Kot velja za vsa antihipertenzivna zdravila, lahko čezmerno znižanje krvnega tlaka pri bolnikih z ishemično boleznijo srca ali aterosklerotično cerebrovaskularno boleznijo izzove miokardni infarkt ali možgansko kap.
Concomitant treatment with baclofen, amifostin, tricyclic antidepressants or neuroleptics may lead to enhancement of the antihypertensive effect and may induce hypotension.
Sočasno zdravljenje z baklofenom, amifostinom, tricikličnimi antidepresivi ali nevroleptiki lahko poveča antihipertenzivni učinek in izzove hipotenzijo.
How to store Atacand Plus Further information
Shranjevanje zdravila Atacand Plus Dodatne informacije
Hydrochlorothiazide is rapidly absorbed from the gastrointestinal tract with an absolute bioavailability of approximately 70%.
Hidroklorotiazid se hitro absorbira iz prebavil in njegova absolutna biološka uporabnost je približno 70 %.
6.6 Special precautions for disposal and other handling No special requirements
6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom Ni posebnih zahtev.
In two studies, both including patients with mild to moderate hepatic impairment, there was an increase in the mean AUC of candesartan of approximately 20% in one study and 80% in the other study (see section 4.2).
V dveh študijah, ki sta obe zajeli bolnike z blago do zmerno okvaro jeter, so v eni študiji ugotovili povečanje povprečne AUC kandesartana za približno 20 % in v drugi za približno 80 % (glejte poglavje 4.2).
• Candesartan cilexetil belongs to a group of medicines called angiotensin II receptor antagonists.
• Cileksetilkandesartanat spada v skupino zdravil, imenovanih antagonisti receptorjev angiotenzina II.
Very rarely, hypotension may be severe such that it may warrant the use of intravenous fluids and/or vasopressors.
Zelo redko je lahko hipotenzija tako huda, da mora bolnik dobiti intravensko tekočino in/ali vazopresorska zdravila.
Marked hypercalcaemia may be a sign of hidden hyperparathyroidism.
Izrazita hiperkalciemija je lahko znak prikritega hiperparatiroidizma.
The renal excretion of potassium and magnesium increases dose-dependently, while calcium is reabsorbed to a greater extent.
Ledvično izločanje kalija in magnezija se povečuje od odmerka odvisno, kalcij pa se reabsorbira v večji meri.
Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Če nadaljnje zdravljenje z ARAII ni nujno, je treba bolnice, ki načrtujejo nosečnost, prevesti na druga antihipertenzivna zdravila, ki imajo ugotovljen boljši varnostni profil med nosečnostjo.
When driving vehicles or operating machines, it should be taken into account that occasionally dizziness or weariness may occur during treatment with Atacand Plus.
Pri vožnji in upravljanju s stroji je treba upoštevati, da se lahko med zdravljenjem z zdravilom Atacand Plus občasno pojavi omotica ali utrujenost.
Other medicines that may lead to enhancement of the antihypertensive effect such as baclofen (a medicine for relief of spasticity), amifostin (used in cancer treatment) and some antipsychotic medicines.
• Druga zdravila, ki lahko povečajo antihipertenzivni učinek, npr. baklofen (zdravilo za ublažitev spastičnosti), amifostin (uporablja se za zdravljenje raka) ali nekatere antipsihotike.
Monitoring of potassium should be undertaken as appropriate (see section 4.4).
Koncentracijo kalija je treba kontrolirati, kot je primerno (glejte poglavje 4.4).
Atacand Plus is contraindicated in patients with severe hepatic impairment and/or cholestasis (see section 4.3).
Zdravilo Atacand Plus je kontraindicirano pri bolnikih s hudo okvaro jeter in/ali s holestazo (glejte poglavje 4.3).
you have severe liver disease or biliary obstruction (a problem with the drainage of bile from the gall bladder).
- če imate hudo bolezen jeter ali biliarno obstrukcijo (to je motnja odtekanja žolča iz žolčnika).
The plasma protein binding of hydrochlorothiazide is approximately 60%.
Vezava hidroklorotiazida na beljakovine v plazmi je približno 60 %.
The effects of candesartan cilexetil 8-16 mg (mean dose 12 mg) once daily on cardiovascular morbidity and mortality were evaluated in a randomised clinical trial with 4,937 elderly patients (aged 70-89 years, 21% aged 80 or above) with mild to moderate hypertension followed for a mean of 3.7 years (Study on COgnition and Prognosis in the Elderly).
Učinke odmerkov od 8 do 16 mg cileksetilkandesartanata (povprečni odmerek 12 mg) enkrat na dan na kardiovaskularno obolevnost in umrljivost so ocenili v randomiziranem kliničnem preskušanju 4.937 starejših bolnikov (starih od 70 do 89 let, 21 % starih 80 let ali več) z blago do zmerno hipertenzijo; bolnike so spremljali povprečno 3.7 leta (študija SCOPE; Study on COgnition and Prognosis in the Elderly).
Candesartan and hydrochlorothiazide have additive antihypertensive effects.
Kandesartan in hidroklorotiazid imata aditivne antihipertenzivne učinke.
swelling of the face, lips, tongue and/or throat, which may cause difficulties in swallowing.
• oteklost obraza, ustnic, jezika in/ali žrela, ki lahko povzroči težave pri požiranju.
Hydrochlorothiazide may cause the arterial response to pressor amines (e.g. adrenaline) to decrease but not enough to exclude a pressor effect.
Hidroklorotiazid lahko zmanjša arterijski odziv na presorske amine (npr. adrenalin), vendar ne v tolikšni meri, da bi odpravil presorski učinek.
When AIIRAs are administered simultaneously with non-steroidal anti-inflammatory drugs (NSAIDs) (i.e. selective COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
Če so ARAII uporabljeni sočasno z nesteroidnimi protivnetnimi zdravili (NSAID) (tj. selektivnimi zaviralci COX-2, acetilsalicilno kislino (> 3 g/dan) ali neselektivnimi nesteroidnimi protivnetnimi zdravili), se lahko antihipertenzivni učinek zmanjša.
you have severe kidney problems.
- če imate hude težave z ledvicami.
Marketing Authorisation Holder and Manufacturer [See Annex I - To be completed nationally] {Name and address of the manufacturer} {tel} {fax} {e-mail}
Imetnik dovoljenja za promet in izdelovalec [Glejte Dodatek I - izpolni država članica] {Ime in naslov izdelovalca} {tel.} {faks} {e-pošta}
Data from in vitro and in vivo genotoxicity testing indicate that candesartan and hydrochlorothiazide are unlikely to exert any mutagenic or clastogenic activity under conditions of clinical use.
Podatki testiranja genotoksičnosti in vitro in in vivo kažejo, da ni verjetno, da bi kandesartan in hidroklorotiazid v pogojih klinične uporabe delovala mutageno ali klastogeno.
Periodic monitoring of serum potassium is recommended when Atacand Plus is administered with such medicinal products, and with the following medicinal products that could induce torsades de pointes:
Redne kontrole kalija v serumu so priporočljive, če je zdravilo Atacand Plus uporabljeno s takšnimi zdravil ter z naslednjimi zdravili, ki lahko izzovejo torsades de pointes:
PARTICULARS TO APPEAR ON THE OUTER PACKAGING AND THE IMMEDIATE PACKAGING CARTON FOR BLISTER / CARTON FOR BOTTLE / LABEL FOR BOTTLE
PODATKI NA ZUNANJI OVOJNINI NA PRIMARNI OVOJNINI ŠKATLA ZA PRETISNI OMOT / ŠKATLA ZA STEKLENIČKO / NALEPKA ZA STEKLENIČKO
Thiazides in high doses causing intense diuresis can inhibit the milk production.
Tiazidi v visokih odmerkih povzročajo intenzivno diurezo in lahko zavrejo nastajanje mleka.
The relative bioavailability of a tablet formulation of candesartan cilexetil compared with the same oral solution is approximately 34% with very little variability.
Relativna biološka uporabnost tablet cileksetilkandesartanata je v primerjavi z isto peroralno raztopino približno 34 % in kaže zelo majhno variabilnost.
The following measures are, however, suggested in case of overdose.
A v primeru prevelikega odmerjanja je predlagano ukrepanje naslednje.
Hypersensitivity to the active substances or to any of the excipients or to sulfonamide derived active substances.
Preobčutljivost za zdravilni učinkovini, katerokoli pomožno snov ali katerokoli sulfonamidno zdravilno učinkovino.
Hydrochlorothiazide is not metabolised and is excreted almost entirely as unchanged drug by glomerular filtration and active tubular secretion.
Hidroklorotiazid se ne presnovi in se izloči skoraj izključno kot nespremenjeno zdravilo z glomerularno filtracijo in aktivno tubularno sekrecijo.
Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
Preobčutljivostne reakcije na hidroklorotiazid se lahko pojavijo tako pri bolnikih z anamnezo alergije ali bronhialne astme kot pri bolnikih brez takšne anamneze, vendar so pri bolnikih s takšno anamnezo verjetnejše.
If this is severe then you may notice weakness, lack of energy, or muscle cramps.
Če je to znižanje hudo, lahko občutite šibkost, pomanjkanje energije ali mišične krče.
If you stop taking Atacand Plus, your blood pressure may increase again.
Če ste prenehali jemati zdravilo Atacand Plus Če prenehate jemati zdravilo Atacand Plus, se vam krvni tlak lahko spet zviša.
you have ever had a disease called systemic lupus erythaematosus (SLE) you have low blood pressure you have ever had a stroke.
- če ste kdaj imeli bolezen, imenovano sistemski eritematozni lupus - če imate nizek krvni tlak.
[See Annex I - To be completed nationally] candesartan cilexetil/hydrochlorothiazide
[Glejte Dodatek I - izpolni država članica] cileksetilkandesartanat/hidroklorotiazid
The table below presents adverse reactions with hydrochlorothiazide monotherapy usually with doses of 25 mg or higher.
Spodnja preglednica navaja neželene učinke monoterapije s hidroklorotiazidom, po navadi z odmerkih 25 mg ali več.
If you take more Atacand Plus than you should If you take more Atacand Plus than prescribed by your doctor, contact a doctor or pharmacist immediately for advice.
Če ste vzeli večji odmerek zdravila Atacand Plus, kot bi smeli Če ste vzeli več zdravila Atacand Plus, kot vam ga je predpisal zdravnik, se nemudoma posvetujte z zdravnikom ali s farmacevtom.
If you are not sure if any of these apply to you, talk to your doctor or pharmacist before taking Atacand Plus.
Če niste prepričani, ali kaj od tega velja za vas, se posvetujte z zdravnikom ali s farmacevtom, preden vzamete zdravilo Atacand Plus.
In elderly subjects (over 65 years), Cmax and AUC of candesartan are increased by approximately 50% and 80%, respectively in comparison to young subjects.
Pri starejših osebah (nad 65 let) se Cmax v primerjavi z mladimi osebami poveča za približno 50 %, AUC pa za približno 80 %.
Summary of product characteristics
POVZETEK GLAVNIH ZNAČILNOSTI ZDRAVILA
In controlled clinical trials comparing candesartan cilexetil with ACE inhibitors, the incidence of cough was lower in patients receiving candesartan cilexetil.
V kontroliranih kliničnih preskušanjih, ki so primerjala kandesartan z zaviralci ACE, je bila incidenca kašlja manjša pri bolnikih, ki so prejemali cileksetilkandesartanat.