natgillin/translations-raw huggingface dataset:
• Anxiety, nervousness, panic disorder (recurring panic attacks), confusion, depression, abnormal dreams, sleep disorders, sleepiness, memory impairment,
• zaskrbljenost, živčnost, panična motnja (ponavljajoči napadi panike), zmedenost, depresija, nenormalne sanje, motnje spanja, zaspanost, motnje spomina
Use in patients with renal impairment and haemodialysis patients No initial dosage adjustment is necessary in patients with moderate renal impairment (i.e. creatinine clearance 30-50 ml/min).
Uporaba pri bolnikih z okvaro ledvic in bolnikih na hemodializi Bolnikom z zmerno okvaro ledvic (to je s kreatininskim očistkom 30-50 ml/min) začetnega odmerka ni treba prilagoditi.
Thiazide therapy may precipitate hyperuricemia and/or gout in certain patients.
Zdravljenje s tiazidi lahko pri nekaterih bolnikih povzroči hiperurikemijo in/ali protin.
If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias.
Če je bolnik vzel tudi digitalis, lahko hipokaliemija izzove srčne aritmije.
Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hours, respectively.
Povprečne najvišje koncentracije losartana in njegovega aktivnega presnovka so dosežene po 1 oz. 3-4 urah.
Cozaar Comp Forte 100 mg/25 mg filmdragerade tabletter United Kingdom COZAAR-COMP 50/12.5MG FILM COATED TABLETS United Kingdom COZAAR-COMP 100/25MG FILM COATED TABLETS United Kingdom COZAAR-Comp
Cozaar Comp Forte 100 mg/25 mg filmdragerade tabletter Velika Britanija COZAAR-COMP 50/12.5MG FILM COATED TABLETS Velika Britanija COZAAR-COMP 100/25MG FILM COATED TABLETS Velika Britanija COZAAR-Comp
Losartan should be used with caution in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.
Losartan je treba pri bolnikih z obojestranskim zožanjem ledvične arterije ali zožanjem arterije ene same delujoče ledvice previdno uporabljati.
Symptomatic hypotension, especially after the first dose, may occur in patients who are volumeand/or sodium-depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or vomiting.
Simptomatska hipotenzija, posebej po prvem odmerku, se lahko pojavi pri bolnikih z zmanjšanim intravaskularnim volumnom in/ali zmanjšano količino natrija zaradi zdravljenja z velikimi odmerki diuretikov, diete z omejitvijo količine soli v hrani, driske ali bruhanja).
• Frequent urination including at night, abnormal kidney function including inflammation of the kidneys, urinary infection, sugar in the urine,
• pogosto uriniranje (tudi ponoči), nenormalno delovanje ledvic, vključno z vnetjem ledvic, vnetjem mehurja in sečnice, sladkor v urinu
The occurrence of hypotension was dose related in these heart failure patients.
Pojav hipotenzije je bil pri teh bolnikih s srčnim popuščanjem odvisen od odmerka.
- The scope of the referral was the harmonisation of the Summaries of Products Characteristics, labelling and package leaflet.
- je bil okvir napotitvenega postopka uskladitev povzetkov glavnih značilnosti zdravila, označevanja in navodil za uporabo,
If you forget to take Cozaar Comp
Če ste pozabili vzeti zdravilo Cozaar Comp
Pharmacotherapeutic group: Combination containing an angiotensin II-receptor(type AT1)-antagonist and a thiazide diuretic, Antihypertensive, ATC code: C09DA01
Farmakoterapevtska skupina: kombinacija antagonista angiotenzina II (tipa AT1) in tiazidnega diuretika, antihipertenziv
Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively.
Holestiraminske in kolestipolne smole v enkratnem odmerku vežejo hidroklorotiazid in zmanjšajo njegovo absorpcijo iz prebavnega trakta, in sicer holestiraminske smole za do 85 %, kolestipolne pa za do 43 %.
• Treatment of hypertension in patients whose blood pressure is not adequately controlled on losartan or hydrochlorothiazide.
• zdravljenje hipertenzije pri bolnikih, katerih krvnega tlaka ni mogoče primerno nadzorovati z losartanom ali hidroklorotiazidom.
• Blurred vision, burning or stinging in the eyes, conjunctivitis, worsening eyesight, seeing things in yellow,
• zamegljen vid, pekoč občutek ali občutek zbadanja v očeh, vnetje očesne veznice, slabši vid, videnje stvari v rumeni barvi
Blood and lymphatic system disorders Uncommon: Anaemia, Henoch-Schönlein purpura, ecchymosis, haemolysis
Bolezni krvi in limfatičnega sistema občasne: anemija, Henoch-Schönleinova purpura, ekhimoza, hemoliza
Light yellow, oval film-coated tablets marked 747 on one side and plain on the other.
Svetlo rumene, ovalne filmsko obložene tablete z oznako 747 na eni strani in brez oznake na drugi strani.
For patients who do not respond adequately to Cozaar Comp 50 mg/12.5 mg, the dosage may be increased to one tablet of Cozaar Comp 100 mg/25 mg (losartan 100 mg/ HCTZ 25 mg) once daily.
Pri bolnikih, ki se na zdravilo Cozaar Comp 50 mg/12,5 mg ne odzivajo ustrezno, lahko odmerek povečate na eno tableto Cozaar Comp 100 mg/25 mg (losartan 100 mg/HCTZ 25 mg) enkrat na dan.
Cytotoxic agents (eg cyclophosphamide, methotrexate) Thiazides may reduce the renal excretion of cytotoxic medicinal products and potentiate their myelosuppressive effects.
Citotoksična zdravila (npr. ciklofosfamid, metotreksat) Tiazidi lahko zmanjšajo izločanje citotoksičnih zdravil skozi ledvice in okrepijo njihove mielosupresivne učinke.
NAME OF THE MEDICINAL PRODUCT Cozaar Comp and associated names (see Annex I) 50 mg/12.5 mg film-coated tablets Cozaar Comp and associated names (see Annex I) 100 mg/12.5 mg film-coated tablets Cozaar Comp and associated names (see Annex I) 100 mg/25 mg film-coated tablets [To be implemented nationally]
Cozaar Comp in povezana imena (glejte Dodatek I) 50 mg/12,5 mg filmsko obložene tablete Cozaar Comp in povezana imena (glejte Dodatek I) 100 mg/12,5 mg filmsko obložene tablete Cozaar Comp in povezana imena (glejte Dodatek I) 100 mg/25 mg filmsko obložene tablete [Izpolni država članica]
HYZAAR (Losartan/Hydrochlorothiazide) Luxembourg COZAAR PLUS FORTE 100 MG/25 MG Luxembourg COZAAR PLUS 50 MG/12,5 MG Luxembourg LOORTAN PLUS FORTE 100 mg/25 mg Luxembourg LOORTAN PLUS 50 mg/12,5 mg Malta
HYZAAR (Losartan/Hydrochlorothiazide) Luksemburg COZAAR PLUS FORTE 100 MG/25 MG Luksemburg COZAAR PLUS 50 MG/12,5 MG Luksemburg LOORTAN PLUS FORTE 100 mg/25 mg Luksemburg LOORTAN PLUS 50 mg/12,5 mg Madžarska Hyzaar 50/12.5 mg
After the discontinuation of losartan,PRA and angiotensin II values fell within 3 days to the baseline values.
Po prekinitvi zdravljenja z losartanom so aktivnost renina v plazmi in vrednosti angiotenzina II v 3 dneh padle na začetne vrednosti.
• Pins and needles or similar sensations, pain in the extremities, trembling, migraine, fainting,
• mravljinčenje ali podobni občutki, bolečine v udih, tresenje, migrena, omedlevica
The data available do not show that a first line therapy with the FDC is of advantage as compared to a stepwise approach within the approved indication.
Razpoložljivi podatki ne kažejo, da bi imelo v okviru odobrene indikacije zdravljenje prve izbire s fiksno kombinacijo odmerkov prednosti v primerjavi s pristopom k zdravljenju po korakih.
Increase of the bioavailability to thiazide-type diuretics by decreasing gastrointestinal motility and stomach emptying rate.
Povečanje biološke uporabnosti tiazidnih diuretikov zaradi zmanjšane motilitete prebavil in hitrosti praznjenja želodca.
Therefore Cozaar Comp is contraindicated in patients with severe hepatic impairment (see sections 4.2, 4.3 and 5.2).
Zato je zdravilo Cozaar Comp pri bolnikih s hudo jetrno okvaro kontraindicirano (glejte poglavja 4.2, 4.3 in 5.2).
Cozaar Comp 100/12.5 (losartan 100 mg/ HCTZ 12.5 mg) is available for those patients titrated to 100 mg of Cozaar Comp who require additional blood pressure control.
Cozaar Comp 100 mg/12,5 mg (losartan 100 mg/HCTZ 12,5 mg) je na voljo za bolnike, ki ob zdravljenju z zdravilom Cozaar 100 mg potrebujejo dodaten nadzor krvnega tlaka.
Cozaar Comp is indicated for the treatment of essential hypertension in patients whose blood pressure is not adequately controlled on losartan or hydrochlorothiazide alone.
Zdravilo Cozaar Comp je indicirano za zdravljenje esencialne hipertenzije pri bolnikih, pri katerih krvni tlak samo z losartanom ali samo s hidroklorotiazidom ni ustrezno nadzorovan.
Administration of losartan blocks all the physiologically relevant actions of angiotensin II and through inhibition of aldosterone could tend to attenuate the potassium loss associated with the diuretic.
Losartan zavira vse fiziološko pomembne učinke angiotenzina II in preko inhibicije aldosterona lahko zmanjša izgubo kalija, ki jo povzroči diuretik.
• Sore throat, breathlessness, bronchitis, pneumonia, water on the lungs (which causes difficulty breathing), nosebleed, runny nose, congestion,
• boleče grlo, zasoplost, bronhitis, pljučnica, voda v pljučih (ki otežuje dihanje), krvavitev iz nosu, smrkanje, zamašen nos
• if you have heart failure
• če imate srčno popuščanje.
The treatment with a thiazide may influence the glucose tolerance.
Zdravljenje s tiazidi lahko poslabša toleranco za glukozo.
Dose titration with the individual components (losartan and hydrochlorothiazide) is recommended.
Priporočamo titriranje odmerkov s posameznima učinkovinama (losartanom in hidroklorotiazidom).
Losartan and hydrochlorothiazide is not for use as initial therapy, but in patients whose blood pressure is not adequately controlled by losartan potassium or hydrochlorothiazide alone.
Kombinacija losartana in hidroklorotiazida ni namenjena za začetno zdravljenje, ampak bolnikom, pri katerih krvni tlak samo z losartanom ali samo s hidroklorotiazidom ni ustrezno nadzorovan.
Common: Hyperkalaemia, mild reduction of haematocrit and haemoglobin Uncommon: Mild increase in urea and creatinine serum levels Very rare: Increase in hepatic enzymes and bilirubin.
Preiskave pogoste: hiperkaliemija, blago znižan hematokrit in hemoglobin občasne: blago zvišanje sečnine v serumu in kreatinina v serumu zelo redke: zvišanje jetrnih encimov in bilirubina
The usual maintenance dose of Cozaar Comp is one tablet of Cozaar Comp 50 mg/12.5 mg (losartan 50 mg/HCTZ 12.5 mg) once daily.
Običajni vzdrževalni odmerek zdravila Cozaar Comp je ena tableta Cozaar Comp 50 mg/12,5 mg (losartan 50 mg/HCTZ 12,5 mg) enkrat na dan.
In nondiabetic hypertensive patients with proteinuria, the administration of losartan potassium significantly reduces proteinuria, fractional excretion of albumin and IgG.
Pri hipertonikih, ki nimajo sladkorne bolezni, imajo pa proteinurijo, dajanje losartana pomembno zmanjša proteinurijo, frakcijsko izločanje albumina in IgG.
• Class Ia antiarrythmics (eg quinidine, hydroquinidine, disopyramide).
• antiaritmiki razreda Ia (npr. kinidin, hidrokinidin, disopiramid)
If goal blood pressure (<140/90 mmHg) was not reached, hydrochlorothiazide (12.5 mg) was added first and, if needed, the dose of losartan or atenolol was then increased to 100 mg once daily.
Če ciljnega krvnega tlaka (< 140/90 mmHg) niso dosegli, so najprej dodali hidroklorotiazid (12,5 mg), potem pa so, če je bilo potrebno, povečali odmerek losartana ali atenolola na 100 mg enkrat na dan. Za doseg ciljnega krvnega tlaka so, če je bilo potrebno, dodali še druge antihipertenzive, razen zaviralcev ACE, antagonistov angiotenzina II ali beta zaviralcev.
During the administration of losartan the removal of the angiotensin II negative feedback on renin secretion leads to increased plasma-renin activity (PRA).
Med dajanjem losartana odsotnost negativne povratne zveze angiotenzina II na izločanje renina povzroči povečano aktivnost renina v plazmi.
Exacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazides.
Pri uporabi tiazidov so poročali tudi o poslabšanju ali aktivaciji sistemskega eritematoznega lupusa.
If you become pregnant while on Cozaar Comp, tell your doctor immediately.
Če jemljete zdravilo Cozaar Comp in zanosite, se takoj posvetujte z zdravnikom.
Electrolyte imbalances are common in patients with renal impairment, with or without diabetes, and should be addressed.
Pri bolnikih z okvaro ledvic, s sladkorno boleznijo ali brez nje, so pogosta elektrolitska neravnovesja, ki jih je potrebno urediti.
The active substances are losartan potassium and hydrochlorothiazide.
Zdravilni učinkovini sta kalijev losartanat in hidroklorotiazid.
Belgium Merck Sharp & Dohme BVChaussée de Waterloo 1135 - B-1180 Brussels
Merck Sharp & Dohme BVChaussée de Waterloo 1135 - B1180 Bruselj
the CHMP has recommended the amendment of the Marketing Authorisation(s) for which the Summary of Product Characteristics, labelling and package leaflet are set out in Annex III for Cozaar Comp. and associated names (see Annex I).
je CHMP za zdravilo Cozaar Comp. in z njim povezana imena (glejte Dodatek I) priporočil spremembo dovoljenj za promet z zdravilom, katerih povzetek glavnih značilnosti zdravila, označevanje in navodila za uporabo so opredeljeni v Dodatku III.
As with any antihypertensive agents, excessive blood pressure decrease in patients with ischaemic cardiovascular and cerebrovascular disease could result in a myocardial infarction or stroke.
Koronarna srčna bolezen in možganskožilna bolezen Tako kot pri drugih antihipertenzivih lahko preveliko znižanje krvnega tlaka pri bolnikih z ishemično srčnožilno in možganskožilno boleznijo povzroči miokardni infarkt ali možgansko kap.
Neither losartan nor the active metabolite can be removed by hemodialysis.
S hemodializo ne moremo odstraniti niti losartana niti njegovega aktivnega presnovka.
Musculoskeletal and connective tissue disorders Common: Muscle cramp, back pain, leg pain, myalgia Uncommon: Arm pain, joint swelling, knee pain, musculoskeletal pain, shoulder pain, stiffness, arthralgia, arthritis, coxalgia, fibromyalgia, muscle weakness
Bolezni mišično-skeletnega sistema in vezivnega tkiva pogoste: mišični krči, bolečina v hrbtu, bolečina v nogi, mialgija občasne: boleča roka, otekel sklep, boleče koleno, mišično-skeletne bolečine, bolečine v rami, okornost, artralgija, artritis, bolečina v kolku, fibromialgija, šibkost mišic
Periodic monitoring of serum potassium and ECG is recommended when Losartan/hydrochlorothiazide is administered with medicinal products affected by serum potassium disturbances (e.g. digitalis glycosides and antiarrhythmics) and with the following torsades de pointes
Zdravila, na katera vplivajo spremenjene vrednosti kalija v serumu Periodično spremljanje vrednosti kalija v serumu in EKG priporočamo, kadar se losartan/hidroklorotiazid uporablja z zdravili, na katera vplivajo spremembe količine kalija v serumu (npr. glikozidi digitalisa in antiaritmiki), in z naslednjimi zdravili, ki povzročajo torsades de pointes ventrikularno tahikardijo (vključno z nekaterimi antiaritmiki), katere glavni povzročitelj je hipokaliemija:
Merck Sharp & Dohme Ltd., Hertfordshire Road, Hoddesdon, Hertfordshire, EN11 9BU, United Kingdom
Merck Sharp & Dohme Ltd., Hertfordshire Road, Hoddesdon, Hertfordshire, EN11 9BU, Velika Britanija
Use in patients with intravascular volume depletion Volume and /or sodium depletion should be corrected prior to administration of Losartan/HCTZ tablets.
Uporaba pri bolnikih z zmanjšanim intravaskularnim volumnom Pred uporabo tablet losartan/HCTZ je treba pozdraviti zmanjšanje intravaskularnega volumna in/ali količine natrija.
Patients should be rehydrated before the administration.
Bolnike je treba pred uporabo jodovega kontrastnega sredstva rehidrirati.
The diuretic action of HCTZ reduces plasma volume, with consequent increase in plasma renin activity, increase in adolsterone secretion, increase in urinary K+ and HCO-3 loss, and decrease in plasma K+.
Diuretični učinek HCTZ zmanjša prostornino plazme, kar posledično poveča aktivnost plazemskega renina, sekrecijo aldosterona, izgubo K+ in HCO-3 v urinu ter zmanjša koncentracijo K+ v plazmi.
The use of Cozaar Comp is contra-indicated during the 2nd and 3rd trimester of pregnancy (see section 4.3 and 4.4).
Uporaba zdravila Cozaar je kontraindicirana v 2. in 3. trimesečju nosečnosti (glejte poglavji 4.3 in
• Hives, itching, inflammation of the skin, rash, redness of the skin, sensitivity to light, dry skin, flushing, sweating, hair loss,
• koprivnica, srbenje, vnetje na koži, izpuščaj, rdečina na koži, občutljivost na svetlobo, suha koža, zardevanje, potenje, izpadanje las
Uncommon: Agranulocytosis, aplastic anaemia, haemolytic anaemia, leukopenia, purpura, thrombocytopenia
Občasne: agranulocitoza, aplastična anemija, hemolitična anemija, levkopenija, purpura, trombocitopenija
Always take Cozaar Comp exactly as your doctor has instructed you.
Zdravilo Cozaar Comp poskusite jemati tako, kot vam je predpisal zdravnik.
The renin-aldosterone link is mediated by angiotensin II and therefore coadministration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with thiazide diuretics.
Zanko renin-aldosteron uravnava angiotenzin II, zato sočasna uporaba antagonista receptorjev angiotenzina II zaustavi izgubo kalija, povezano s tiazidnimi diuretiki.
• Weakness, tiredness, chest pain,
• slabotnost, urujenost, bolečina v prsnem košu
• Muscle pain or cramps, leg pain, back pain,
• bolečine v mišicah, mišični krči, bolečine v nogah, bolečine v hrbtu
The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity and increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium.
Z diuretičnim učinkom hidroklorotiazid zmanjša volumen plazme, poveča reninsko aktivnost v plazmi ter poveča izločanje aldosterona, s posledičnim povečanjem kalija v urinu in zmanjšanjem bikarbonata, in zmanjša količino kalija v serumu.
Film coated tablets
Filmsko obložene tablete.
Angiooedema
Angioedem
• Insomnia, headache, dizziness,
• nespečnost, glavobol, omotica
Luxembourg Merck Sharp & Dohme BVChaussée de Waterloo 1135 - B-1180 Brussels, Belgium
Luksemburg Merck Sharp & Dohme BVChaussée de Waterloo 1135 - B1180 Bruselj, Belgija
Iodine Contrast Media
Jodirano kontrastno sredstvo
Merck Sharp & Dohme Limited Hertford Road, Hoddesdon, Herts EN11 9BU, United Kingdom
Velika Britanija Merck Sharp & Dohme Limited Hertford Road, Hoddesdon, Herts EN11 9BU, Velika Britanija
As with other drugs that affect the renin-angiotensin-aldosterone system, increases in blood urea and serum creatinine have also been reported in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney; these changes in renal function may be reversible upon discontinuation of therapy.
Tako kot pri drugih zdravilih, ki vplivajo na sistem renin-angiotenzin-aldosteron, so pri bolnikih z obojestranskim zožanjem ledvične arterije ali zožanjem arterije ene same delujoče ledvice poročali o zvišanju sečnine v krvi in zvišanju kreatinina v serumu.
Losartan and hydrochlorothiazide tablets are not recommended for haemodialysis patients.
Kombinacije losartan/HCTZ ne priporočamo bolnikom na hemodializi.
Cozaar Comp 100 mg/12.5 mg also contain: white color concentrate [or the individual ingredients of the concentrate: hydroxypropyl cellulose (E463), hypromellose (E464) and titanium dioxide (E171)] and carnauba wax (E903).
Cozaar Comp 100 mg/12,5 mg vsebuje tudi: koncentrat bele barve [ali posamezne sestavine koncentrata: hidroksipropilcelulozo (E463), hipromelozo (E464) in titanov dioksid (E171)] in karnauba vosek (E903).
The CHMP considered that the following warnings should be included in the SPC in all MSs: Haemodialysis; Black patients; Obstructive valvular disease; Surgery/anaesthesia.
Poglavje 4.4 Posebna opozorila in previdnostni ukrepi CHMP je menil, da je treba v vseh različicah povzetka glavnih značilnosti zdravila vključiti naslednja opozorila: hemodializa; črni bolniki; obstruktivna bolezen srčnih zaklopk; kirurški poseg/anestezija.
Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.
Hidroklorotiazid prehaja placento, vendar ne prehaja krvno-možganske bariere.
Dosage adjustment of uricosuric medicinal products may be necessary since hydrochlorothiazide may raise the level of serum uric acid.
Zdravila za zdravljenje protina (probenecid, sulfinpirazon in alopurinol) Morda je treba prilagoditi odmerjanje urikozuričnih zdravil, ker hidroklorotiazid lahko poveča količino sečne kisline v serumu.
Angiotensin II binds to the AT1 receptor found in many tissues (e.g. vascular smooth muscle, adrenal gland, kidneys and the heart)
Angiotenzin II se veže na AT1 receptorje, ki se nahajajo v številnih tkivih (npr. gladkih mišicah krvnih žil, nadledvični žlezi, ledvicah in srcu), in sproži več pomembnih bioloških učinkov, vključno z vazokonstrikcijo in sproščanjem aldosterona.
Because losartan decreases uric acid, losartan in combination with hydrochlorothiazide attenuates the diureticinduced hyperuricemia.
Losartan znižuje koncentracijo sečne kisline v krvi, zato v kombinaciji s hidroklorotiazidom ublaži hiperurikemijo, ki jo povzroči diuretik.
Merck Sharp & Dohme GmbH Donau-City-Straße 6
Merck Sharp & Dohme GmbH Donau-City-Straße 6, 1220 Dunaj Avstrija
• Constipation, wind, stomach upsets, stomach spasms, vomiting, dry mouth, inflammation of a salivary gland, toothache,
• zaprtje, vetrovi, razdražen želodec, krči želodca, bruhanje, suha usta, vnetje žleze slinavke, zobobol
What Cozaar Comp looks like and contents of the pack Cozaar Comp 50 mg/12.5 mg is supplied as scored or unscored film-coated tablets.
Izgled zdravila Cozaar Comp in vsebina pakiranja Cozaar Comp 50 mg/12,5 mg je na voljo v obliki filmsko obloženih tablet z ali brez razdelilne zareze.
Dilutional hyponatraemia may occur in oedematous patients in hot weather.
V vročem vremenu se pri bolnikih z edemi lahko pojavi dilucijska hiponatriemija.
Cozaar Comp 50 mg/12.5 mg Each tablet contains 63.13 mg lactose monohydrate.
Cozaar Comp 50 mg/12,5 mg Vsaka tableta vsebuje 63,13 mg laktoze monohidrata.
Store Cozaar Comp in the original package.
Zdravilo Cozaar Comp shranjujte v originalni ovojnini.
• Cough, upper airway infection, congestion in the nose, sinusitis, sinus disorder,
• kašelj, okužba zgornjih dihal, zamašen nos, vnetje sinusov, težave s sinusi
Uncommon: Hypotension, orthostatic hypotension, sternalgia, angina pectoris, grade II-AV block, cerebrovascular event, myocardial infarction, palpitation, arrhythmias (atrial fibrillations, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation)
stopnje, cerebrovaskularni dogodek, miokardni infarkt, palpitacije, aritmije (atrijska fibrilacija, sinusna bradikardija, tahikardija, ventrikularna tahikardija,fibrilacija ventriklov)
Sweden Merck Sharp & Dohme PO Box 581
Nizozemska Merck Sharp & Dohme PO Box 581
PHARMACEUTICAL FORM AND CONTENTS 4, 7, 10, 14, 20, 28, 30, 50, 56, 84, 98, or 280 film-coated tablets.
FARMACEVTSKA OBLIKA IN VSEBINA 4, 7, 10, 14, 20, 28, 30, 50, 56, 84, 98 ali 280 filmsko obloženih tablet.
Pregnancy and Lactation should be contraindicated and the appropriate wording included in sections 4.3, 4.4 and 4.6 of the SPC, and the relevant sections of the Package Leaflet.
Nosečnost in dojenje je treba kontraindicirati, v poglavja 4.3, 4.4 in 4.6 povzetka glavnih značilnosti zdravila ter ustrezna poglavja navodil za uporabo pa vnesti primerno besedilo.
Coadministration of a thiazide may increase the incidence of hypersensitivity reactions to allopurinol.
Sočasna uporaba tiazida lahko poveča pojavnost preobčutljivostnih reakcij na alopurinol.
The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study was a randomised, triple-blind, active-controlled study in 9193 hypertensive patients aged 55 to 80 years with ECGdocumented left ventricular hypertrophy.
Vključevala je 9.193 hipertenzivnih bolnikov, starih od 55 do 80 let, z EKG-jem potrjeno hipertrofijo levega prekata.
Vascular disorders Uncommon: Vasculitis
Žilne bolezni občasne: vaskulitis