natgillin/translations-raw huggingface dataset:
Gastric acid suppression during treatment with esomeprazole and other PPIs might decrease or increase the absorption of medicinal products with a gastric pH dependent absorption.
Zavrtje izločanja želodčne kisline med zdravljenjem z esomeprazolom in drugimi zaviralci protonske črpalke lahko zmanjša ali poveča absorpcijo zdravil, katerih absorpcija je odvisna od pH v želodcu.
As a precautionary measure, it is preferable to avoid the use of Nexium Control during pregnancy.
Zaradi previdnosti je bolje, da se zdravila Nexium Control med nosečnostjo ne uporablja.
• They have significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis or melaena and when gastric ulcer is suspected or present, malignancy should be excluded as treatment with esomeprazole may alleviate symptoms and delay diagnosis.
• v primeru izrazitega in nenamernega hujšanja, ponavljajočega se bruhanja, disfagije, hematemeze ali melene in pri sumu na želodčni ulkus ali ugotovljenem želodčnem ulkusu; v takšnem primeru je treba izključiti maligno bolezen, kajti zdravljenje z esomeprazolom lahko ublaži simptome in zapozni postavitev diagnoze.
If affected, you should not drive or use machines.
Če imate takšne neželene učinke, ne upravljajte vozil ali strojev.
Studies evaluating concomitant administration of esomeprazole and either naproxen or rofecoxib did not identify any clinically relevant pharmacokinetic interactions during short-term studies.
Študije sočasne uporabe esomeprazola z naproksenom ali rofekoksibom med kratkotrajnimi študijami niso pokazale klinično pomembnih farmakokinetičnih medsebojnih delovanj.
Results from studies in healthy subjects have shown a pharmacokinetic (PK)/pharmacodynamic (PD) interaction between clopidogrel (300 mg loading dose/75 mg daily maintenance dose) and esomeprazole (40 mg orally daily) resulting in decreased exposure to the active metabolite of clopidogrel by an average of 40%, and resulting in decreased maximum inhibition of (ADP induced) platelet aggregation by an average of 14%.
Rezultati študije pri zdravih preiskovancih so pokazali farmakokinetično (FK)/farmakodinamično (FD) medsebojno delovanje med klopidogrelom (300 mg polnilni odmerek/75 mg dnevni vzdrževalni odmerek) in esomeprazolom (40 mg na dan peroralno), ki je zmanjšalo izpostavljenost aktivnemu presnovku klopidogrela za povprečno 40 % in je posledično zmanjšalo največje zavrtje (z ADP inducirane) agregacije trombocitov za povprečno 14 %.
Hepatobiliary disorders increased liver enzymes hepatitis with or without jaundice hepatic failure, hepatic encephalopathy in patients with pre-existing liver disease
Bolezni jeter, žolčnika in žolčevodov zvišanje jetrnih encimov hepatitis z zlatenico ali brez nje odpoved jeter, hepatična encefalopatija pri bolnikih s predobstoječo boleznijo jeter
• Reddening of the skin with blisters or peeling.
• pordelost kože z mehurji ali lupljenjem.
• They are aged over 55 years with new or recently changed symptoms.
• če so starejši od 55 let in se jim pojavijo novi simptomi ali so se jim simptomi nedavno spremenili.
If you forget to take Nexium Control
Če ste pozabili vzeti zdravilo Nexium Control
• Try to lose weight.
• poskusite zmanjšati telesno maso;
After repeated administration with 20 mg esomeprazole once daily for five days, mean peak acid output after pentagastrin stimulation is decreased 90% when measured 6-7 hours after dosing on day five.
Po večkratni uporabi 20 mg esomeprazola enkrat na dan pet dni se povprečno največje izločanje kisline po stimulaciji s pentagastrinom, merjeno peti dan od 6 do 7 ur po odmerku, zmanjša za 90 %.
• An infection called “thrush” which can affect the gut and is caused by a fungus.
• okužba, ki jo imenujemo "gobice" in lahko prizadene črevo; povzročajo jo glivice
• Digoxin (used for heart problems)
• digoksin (uporablja se za zdravljenje težav s srcem)
The normal symptoms of reflux are a painful sensation in the chest rising up to your throat (heartburn) and a sour taste in the mouth (acid regurgitation).
Običajni simptomi refluksa so bolečina v prsnem košu, ki se širi proti žrelu (zgaga) in kisel okus v ustih (vračanje kisline).
This is because the capsule contains coated pellets, which stop the medicine from being broken down by the acid in your stomach.
Kapsula namreč vsebuje obložena zrnca, ki preprečijo, da bi kislina v želodcu razgradila zdravilo.
• They have jaundice or severe liver disease.
• če imajo zlatenico ali hudo bolezen jeter.
• Effects on your stomach or gut: diarrhoea, stomach ache, constipation, wind (flatulence).
• učinki na želodec ali črevo: driska, bolečine v trebuhu, zaprtost, vetrovi (flatulenca)
This medicine is used in adults for the short-term treatment of reflux symptoms (for example, heartburn and acid regurgitation).
To zdravilo se uporablja pri odraslih za kratkotrajno zdravljenje simptomov refluksa (npr. zgage in vračanja kisline).
Concomitant administration of 40 mg esomeprazole resulted in a 13% increase in trough plasma levels of phenytoin in epileptic patients.
Sočasna uporaba 40 mg esomeprazola je pri bolnikih z epilepsijo povečala koncentracijo fenitoina v plazmi za 13 %.
Medicinal products known to induce CYP2C19 or CYP3A4 or both (such as rifampicin and St. John's wort (Hypericum perforatum)) may lead to decreased esomeprazole serum levels by increasing the esomeprazole metabolism.
Zdravila, ki inducirajo CYP2C19, CYP3A4 ali oba (npr. rifampicin in šentjanževka (Hypericum perforatum)), lahko zmanjšajo koncentracijo esomeprazola v serumu, ker povečajo njegovo presnovo.
• You begin to vomit food or blood, which may appear as dark coffee grounds in your vomit.
• bruhanje hrane ali krvi; ta je lahko opazna kot temna, kavi podobna zrna v izbruhani vsebini,
Musculoskeletal and connective tissue disorders arthralgia, myalgia muscular weakness
Bolezni mišičnoskeletnega sistema in vezivnega tkiva artralgija, mialgija mišična šibkost
What you need to know before you take Nexium Control
Kaj morate vedeti, preden boste vzeli zdravilo Nexium Control
Aluminium blister.
Aluminijasti pretisni omot.
You may need to take the capsules for 2-3 days in a row before you feel better.
Morda boste morali kapsule jemati 2 ali 3 dni zapored, preden se boste počutili bolje.
The liquid with the pellets should be drunk immediately or within 30 minutes.
Vodo je treba mešati, dokler se tableta ne razpusti, tekočino z zrnci pa je treba popiti takoj ali v 30 minutah.
This is because the tablet contains coated pellets, which stop the medicine from being broken down by the acid in your stomach.
Tableta namreč vsebuje obložena zrnca, ki preprečijo, da bi kislina v želodcu razgradila zdravilo.
EU/1/13/860/001 7 gastro-resistant tablets EU/1/13/860/002 14 gastro-resistant tablets
EU/1/13/860/001 7 gastrorezistentnih tablet EU/1/13/860/002 14 gastrorezistentnih tablet
• You have severe kidney problems.
• imate hudo okvaro ledvic,
• You are aged over 55 years and have new or recently changed reflux symptoms or need to take a non-prescription indigestion or heartburn remedy treatment every day.
• ste starejši od 55 let in se vam pojavijo novi simptomi refluksa ali se vam takšni simptomi v zadnjem času spremenijo ali vsak dan jemljete zdravila proti težavam z želodcem ali zgago, ki ste jih dobili brez recepta,
In a study in healthy subjects, there was a decreased exposure by almost 40% of the active metabolite of clopidogrel when a fixed dose combination of esomeprazole 20 mg + acetylsalicylic acid 81 mg was given with clopidogrel compared to clopidogrel alone.
V študiji pri zdravih preiskovancih se je izpostavljenost aktivnemu presnovku klopidogrela v primeru uporabe fiksnega odmerka kombinacije 20 mg esomeprazola in 81 mg acetilsalicilne kisline skupaj s klopidogrelom zmanjšala za skoraj 40 % v primerjavi z uporabo samega klopidogrela.
Immune system disorders hypersensitivity reactions e.g. fever, angioedema and anaphylactic reaction/shock
Bolezni imunskega sistema preobčutljivostne reakcije, npr. zvišana telesna temperatura, angioedem in anafilaktična reakcija/šok
Take one tablet once a day.
Vzemite eno tableto enkrat na dan. Ne prekoračite tega odmerka.
Take one capsule once a day.
Vzemite eno kapsulo enkrat na dan. Ne prekoračite tega odmerka.
• Rash, possibly with pain in the joints.
• izpuščaj, lahko z bolečino v sklepih
Reproductive system and breast disorders gynaecomastia
Motnje reprodukcije in dojk ginekomastija
General disorders and administration site disorders malaise, increased sweating
Splošne težave in spremembe na mestu aplikacije splošno slabo počutje, močnejše znojenje
• Voriconazole (used to treat infections caused by a fungus) and clarithromycin (used to treat infections).
• vorikonazol (uporablja se za zdravljenje glivičnih okužb) in klaritromicin (uporablja se za zdravljenje okužb).
About 80% of nights were heartburn free during all time periods and 90% of nights were heartburn free by week 2 of each clinical study, compared to 72.4 - 78.3% for placebo.
V obeh kliničnih študijah je bilo približno 80 % vseh noči brez zgage v vseh časovnih obdobjih, po 2 tednih pa je bilo 90 % noči brez zgage v primerjavi z 72,4-78,3% v skupini s placebom.
• Benign growths (polyps) in the stomach.
• benigni polipi v želodcu
Concomitant administration of 40 mg esomeprazole to warfarin-treated patients in a clinical study showed that coagulation times were within the accepted range.
Pri bolnikih, ki so v klinični študiji hkrati dobivali 40 mg esomeprazola in varfarin, so ugotovili koagulacijske čase v sprejemljivem razponu.
Decreased gastric acidity due to any means including PPIs, increases gastric counts of bacteria normally present in the gastrointestinal tract.
Če se kislost v želodcu zmanjša zaradi kakršnegakoli vzroka, vključno z zaviralci protonske črpalke, se v želodcu poveča število bakterij, ki so običajno prisotne v prebavilih.
- If you are taking a medicine containing nelfinavir (used to treat HIV infection).
- Če jemljete kakšno zdravilo, ki vsebuje nelfinavir (uporablja se za zdravljenje okužbe s HIV).
Omeprazole has been reported to interact with some protease inhibitors.
Opisano je, da omeprazol medsebojno deluje z nekaterimi zaviralci proteaz.
The capsules must not be chewed, crushed or opened.
Kapsul se ne sme žvečiti, zdrobiti ali odpreti.
For short-term treatment of reflux symptoms (heartburn, acid regurgitation) in adults, aged 18 or over.
Za kratkotrajno zdravljenje simptomov refluksa (zgage, vračanja kisline) pri odraslih, starejših od 18 let.
Nexium Control is available in a pack size of 14 gastro-resistant hard capsules in high-density polyethylene (HDPE) bottles with an induction seal closure and child resistant closure.
Zdravilo Nexium Control je na voljo v pakiranju s 14 trdimi gastrorezistentnimi kapsulami v plastenkah iz polietilena visoke gostote (HDPE) z indukcijsko zaporko s tesnilom in za otroke varno zaporko.
Nexium Control is indicated for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults.
Zdravilo Nexium Control je indicirano za kratkotrajno zdravljenje simptomov refluksa (npr. zgage in regurgitacije kisline) pri odraslih.
As a precaution, concomitant use of esomeprazole and clopidogrel should be discouraged.
Zaradi previdnosti naj esomeprazola in klopidogrela ne bi uporabljali sočasno.
• Citalopram, imipramine or clomipramine (used to treat depression)
• citalopram, imipramin ali klomipramin (uporabljajo se za zdravljenje depresije)
The tablets must not be chewed or crushed.
Tablet se ne sme žvečiti ali zdrobiti.
It is important for you to give information about your medicine at this time.
V takšnem primeru je pomembno, da zdravnika obvestite, da jemljete to zdravilo.
• Sudden wheezing, swelling of your lips, tongue and throat, rash, fainting, or difficulties in swallowing (severe allergic reaction, seen rarely).
• nenadno piskajoče dihanje, oteklost ustnic, jezika in žrela, izpuščaj, omedlevico ali težave s požiranjem (huda alergijska reakcija, pojavi se redko)
Medicinal products which induce CYP2C19 and/or CYP3A4
Zdravila, ki inducirajo CYP2C19 in/ali CYP3A4
A light pink, oblong, biconvex, film-coated, gastro-resistant tablet of 14 mm x 7 mm engraved with ‘20 mG' on one side and ‘A/EH' on the other side.
Svetlorožnata, podolgovata, bikonveksna filmsko obložena gastrorezistentna tableta velikosti 14 mm x 7 mm z vtisnjeno oznako "20 mG" na eni strani in "A/EH" na drugi strani.
Keep this medicine in the original package in order to protect from moisture.
Zdravilo shranjujte v originalni ovojnini za zagotovitev zaščite pred vlago.
As a precautionary measure, you should preferably avoid the use of Nexium Control during pregnancy.
Zaradi previdnosti je priporočljivo, da se jemanju zdravila Nexium Control med nosečnostjo izognete.
SCLE after previous treatment with a proton pump inhibitor may increase the risk of SCLE with other proton pump inhibitors.
Subakutni kožni eritematozni lupus po predhodnem zdravljenju z zaviralcem protonske črpalke lahko poveča tveganje za pojav subkutanega kožnega eritematoznega lupusa z drugimi zaviralci protonske črpalke.
Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H
V močno kislem okolju sekretornih kanalčkov parietalnih celic se koncentrira in pretvori v aktivno obliko ter zavira encim H
• Atazanavir, saquinavir (used to treat HIV infection)
• atazanavir, sakvinavir (uporabljata se za zdravljenje okužbe s HIV)
Concomitant administration of esomeprazole and a combined inhibitor of CYP2C19 and CYP3A4 may result in more than doubling of the esomeprazole exposure.
Sočasna uporaba esomeprazola in kakšnega kombiniranega zaviralca CYP2C19 in CYP3A4 lahko več kot podvoji izpostavljenost esomeprazolu.
The major metabolites of esomeprazole have no effect on gastric acid secretion.
Glavni presnovki esomeprazola ne vplivajo na izločanje želodčne kisline.
However, post-marketing, a few isolated cases of elevated INR of clinical significance have been reported during concomitant treatment.
Po prihodu zdravila na trg pa so med takšnim sočasnim zdravljenjem ugotovili nekaj posameznih primerov klinično pomembnega zvišanja INR.
Inconsistent data on the clinical implications of this PK/PD interaction in terms of major cardiovascular events have been reported from both observational and clinical studies.
Opazovalne in klinične študije so dale neskladne podatke o kliničnih posledicah tega farmakokinetičnega/farmakodinamičnega medsebojnega delovanja, kar zadeva pomembne kardiovaskularne dogodke.
Nexium Control has a low likelihood of affecting your ability to drive or use machines.
Malo je verjetno, da bi zdravilo Nexium Control vplivalo na sposobnost upravljanja vozil in strojev.
What Nexium Control looks like and contents of the pack Nexium Control 20 mg gastro-resistant hard capsules are approximately 11 x 5 mm capsules with a clear body, and an amethyst cap imprinted with “NEXIUM 20 MG” in white.
Izgled zdravila Nexium Control in vsebina pakiranja Zdravilo Nexium Control 20 mg kapsule so trde gastrorezistentne kapsule, velike približno 11 x 5 mm, s prozornim telesom in pokrovčkom vijolične barve z natisnjeno oznako "NEXIUM 20MG" v beli barvi.
Nexium Control contains the active substance esomeprazole.
Zdravilo Nexium Control vsebuje učinkovino esomeprazol.
• Erlotinib (used to treat cancer)
• erlotinib (uporablja se za zdravljenje raka)
Single doses of 80 mg esomeprazole were uneventful.
Enkratni odmerki 80 mg esomeprazola niso povzročili simptomov.
You may need to take the tablets for 2-3 days in a row before you feel better.
Morda boste morali tablete jemati 2 ali 3 dni zapored, preden se boste počutili bolje.
Respiratory, thoracic and mediastinal disorders bronchospasm
Bolezni dihal, prsnega koša in mediastinalnega prostora bronhospazem
Capsule approximately 11 x 5 mm, with a clear body, and an amethyst cap imprinted with “NEXIUM 20 MG” in white.
Kapsula, velika približno 11 x 5 mm, s prozornim telesom in pokrovčkom vijolične barve z natisnjeno oznako ''NEXIUM 20 MG'' v beli barvi.
Yellow iron oxide (E172)
Črta želatina rumeni železov oksid (E172)
Medicinal products metabolised by CYP2C19
Zdravila, ki se presnavljajo s CYP2C19
The secondary endpoint of complete resolution of heartburn, defined as no heartburn on the patient's diary card for 7 consecutive days, was statistically significant at both week 1 (10.0% - 15.2% vs placebo 0.9% - 2.4%, p = 0.014, p<0.001) and week 2 (25.2% - 35.7% vs placebo 3.4% - 9.0%, p<0.001).
Sekundarni opazovani dogodek, popolno prenehanje zgage, opredeljen kot odsotnost zgage v bolnikovem dnevniku 7 zaporednih dni, je bil statistično pomemben po enem tednu (10,0-15,2 % v primerjavi s placebom 0,9-2,4 %, p = 0,014, p < 0,001) in po 2 tednih (25,2-35,7 % v primerjavi s placebom 3,4-9,0 %, p < 0,001).
Esomeprazole is completely eliminated from plasma between doses with no tendency for accumulation during once-daily administration.
Esomeprazol se med odmerki povsem odstrani iz plazme in se med uporabo enkrat na dan ne kopiči.
Posology The recommended dose is 20 mg esomeprazole (one tablet) per day.
Odmerjanje Priporočeni odmerek je 20 mg esomeprazola (ena tableta) na dan.
Alternatively, the tablet can be dispersed in half a glass of non-carbonated water.
Tablete je možno tudi raztopiti v pol kozarca negazirane vode.
The investigators also found esomeprazole to be significantly more effective than placebo in resolving acid regurgitation (58.5% - 63.6% vs placebo 28.3% - 37.4%) during the week 2 evaluation.
Med dvotedenskim vrednotenjem so raziskovalci prav tako ugotovili, da je esomeprazol pomembno učinkovitejši od placeba pri prenehanju regurgitacije kisline (58,5-63,6 % v primerjavi s placebom 28,3-37,4 %).
This may cause you symptoms such as a painful sensation in the chest rising up to your throat (heartburn) and a sour taste in the mouth (acid regurgitation).
Posledica so lahko simptomi, npr. bolečina v prsnem košu, ki se širi proti žrelu (zgaga) ali kisel okus v ustih (vračanje kisline).
Do not take Nexium Control
Ne jemljite zdravila Nexium Control
Esomeprazole is metabolised by CYP2C19 and CYP3A4.
Esomeprazol se presnavlja s CYP2C19 in CYP3A4.
Posology The recommended dose is 20 mg esomeprazole (one capsule) per day.
Odmerjanje Priporočeni odmerek je 20 mg esomeprazola (ena kapsula) na dan.
Nervous system disorders headache dizziness, paraesthesia, somnolence taste disturbance
Bolezni živčevja glavobol omotica, parestezije, zaspanost motnje okušanja
• If your reflux symptoms get worse or do not improve after taking this medicine for 14 days in a row, you should consult a doctor.
• Če se vam simptomi refluksa poslabšajo ali ne izboljšajo po jemanju tega zdravila 14 dni zapored, se posvetujte z zdravnikom.
May take 2-3 days for full effect.
Lahko traja 2-3 dni, preden zdravilo začne popolnoma delovati.
Do not use this medicine after the expiry date which is stated on the carton and the bottle after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli ali plastenki poleg oznake ''Uporabno do'' ali "EXP".
Both the Rand S-isomer of omeprazole have similar pharmacodynamic activity.
Farmakodinamično delovanje R- in S-izomera omeprazola je podobno.
cramps, tremor and changes in heart rhythm (arrhythmias).
tresenje in motnje srčnega ritma (aritmije).
• Dry mouth.
• suhost ust
• You pass black stools (blood-stained faeces).
• iztrebljanje črnega (krvavo obarvanega) blata,
• Joint pain (arthralgia) or muscle pain (myalgia).
• bolečine v sklepih (artralgija) ali mišicah (mialgija)
• Ketoconazole and itraconazole (used to treat infections caused by a fungus).
• ketokonazol in itrakonazol (uporabljata se za zdravljenje glivičnih okužb)
Co-administration of omeprazole (40 mg once daily) with atazanavir 300 mg/ritonavir 100 mg to healthy volunteers resulted in a substantial reduction in atazanavir exposure (approximately 75% decrease in AUC, Cmax, and Cmin).
Sočasna uporaba omeprazola (40 mg enkrat na dan) s 300 mg atazanavirja/100 mg ritonavirja je pri zdravih prostovoljcih bistveno zmanjšala izpostavljenost atazanavirju (približno 75 % zmanjšanje AUC, Cmax in Cmin).
• Suddenly feeling wheezy or short of breath (bronchospasm).
• nenaden pojav piskajočega ali težkega dihanja (bronhospazem)
Treatment with omeprazole 40 mg once a day had no effect on the exposure of lopinavir (with concomitant ritonavir).
Zdravljenje s 40 mg omeprazola enkrat na dan ni vplivalo na izpostavljenost lopinavirju (sočasno z ritonavirjem).
• The other ingredients are: glycerol monostearate 40-55, hydroxypropylcellulose, hypromellose, magnesium stearate, methacrylic acid - ethyl acrylate copolymer (1:1) dispersion 30 per cent, polysorbate 80, sugar spheres (sucrose and maize starch), talc, triethyl citrate, carmine (E120), indigo carmine (E132), titanium dioxide (E171), yellow iron oxide (E172), erythrosine (E127), allura red AC (E129), povidone K-17, propylene glycol, shellac, sodium hydroxide, and gelatin (see section 2, “Nexium Control contains sucrose”.)
• Druge sestavine zdravila so: glicerilmonostearat 40-55, hidroksipropilceluloza, hipromeloza, magnezijev stearat, metakrilna kislina - etilakrilat, kopolimer (1:1), 30-odstotna disperzija, polisorbat 80, sladkorne kroglice (saharoza in koruzni škrob), smukec, trietilcitrat, karmin (E120), indigo karmin (E132), titanov dioksid (E127), rumeni železov oksid (E172), eritrozin (E127), alura rdeče AC (E129), povidon K-17, propilenglikol, šelak, natrijev hidroksid in želatina (glejte poglavje 2 ''Zdravilo Nexium Control vsebuje saharozo'').
• Tacrolimus (in cases of organ transplantation)
• takrolimus (uporablja se po presaditvi organov)
Following Overall Treatment Evaluation (OTE) of patients at week 2, 78.0-80.7% of patients on esomeprazole 20 mg, compared to 72.4 - 78.3% for placebo, reported their condition as improved.
Po skupni oceni zdravljenja po 2 tednih je 78,0-80,7 % bolnikov, ki so dobivali 20 mg esomeprazola, poročalo o izboljšanem stanju v primerjavi z 72,4-78,3 % v skupini s placebom.
14 gastro-resistant capsules.
14 gastrorezistentnih kapsul
Treatment with omeprazole 20 mg once a day had no effect on the exposure of darunavir (with concomitant ritonavir) and amprenavir (with concomitant ritonavir).
Zdravljenje z 20 mg omeprazola enkrat na dan ni vplivalo na izpostavljenost darunavirju (sočasno z ritonavirjem) in amprenavirju (sočasno z ritonavirjem).
Gastrointestinal disorders abdominal pain, constipation, diarrhoea, flatulence, nausea/ vomiting, fundic gland polyps (benign)
Bolezni prebavil bolečine v trebuhu, zaprtost, driska, flatulenca, navzea/bru -hanje, polipi fundičnih žlez (benigni)
An interaction is observed between clopidogrel and esomeprazole.
Med klopidogrelom in esomeprazolom so ugotovili medsebojno delovanje.
Treatment with esomeprazole 20 mg once a day had no effect on the exposure of amprenavir (with and without concomitant ritonavir).
Zdravljenje z 20 mg esomeprazola enkrat na dan ni vplivalo na izpostavljenost amprenavirju (sočasno z ritonavirjem ali brez njega).
• They have been on continuous symptomatic treatment of indigestion or heartburn for 4 or more weeks.
• če se že 4 tedne ali več neprekinjeno simptomatsko zdravijo težave z želodcem ali zgago.
Time to sustained resolution of heartburn, defined as when 7 consecutive days of no heartburn was first recorded, was significantly shorter in the esomeprazole 20 mg group (39.7% - 48.7% by day 14 vs placebo 11.0% - 20.2%).
Čas do trajnega prenehanja zgage, opredeljen kot 7 zaporednih dni brez zgage od prvega zapisa, je bil pomembno krajši v skupini, ki je dobivala 20 mg esomeprazola (39,7-48,7 % do 14. dneva v primerjavi s placebom 11,0-20,2 %).
If you are overweight or smoke you increase the probability of suffering from heartburn.
Verjetnost zgage se poveča, če imate prekomerno telesno maso ali kadite.