natgillin/translations-raw huggingface dataset:
On 28 April 2016 EMA completed a review of the known risk of pneumonia (lung infection) in patients who take inhaled corticosteroid medicines to treat chronic obstructive pulmonary disease (COPD).
Dne 28. aprila 2016 je agencija EMA zaključila pregled znanega tveganja za pljučnico (okužbo pljuč) pri bolnikih, ki prejemajo inhalacijska kortikosteroidna zdravila za zdravljenje kronične obstruktivne pljučne bolezni (KOPB).
The CHMP's opinion was then sent to the European Commission, which issued a final legally-binding decision valid throughout the EU.
Mnenje odbora CHMP je bilo nato posredovano Evropski komisiji, ki je izdala pravno zavezujoč sklep, veljaven v vsej EU.
When taken by inhalation they attach to receptors in the airways and cause a reduction in lung inflammation, which makes breathing easier.
Pri inhalaciji se pritrdijo na receptorje v dihalnih poteh in zavrejo pljučno vnetje, s čimer postane dihanje lažje.
• Following a review of the available data, EMA has confirmed the risk of pneumonia with inhaled corticosteroids (ICS) in patients with COPD.
• Po pregledu razpoložljivih podatkov je agencija EMA potrdila tveganje za pljučnico pri uporabi inhalacijskih kortikosteroidov (IKS) pri bolnikih s KOPB.
The PRAC recommendations were sent to the Committee for Medicinal Products for Human Use (CHMP), which adopted the Agency's opinion.
Priporočila odbora PRAC so bila poslana Odboru za zdravila za uporabo v humani medicini (CHMP), ki je sprejel končno mnenje agencije.
• Healthcare professionals should remain vigilant for the possible development of pneumonia in patients with COPD as the clinical features of such infections overlap with the symptoms of COPD exacerbations.
• Pri bolnikih s KOPB naj zdravstveni delavci ostanejo pozorni na morebiten razvoj pljučnice, saj se klinične značilnosti takih okužb prekrivajo s simptomi poslabšanj KOPB.
The review has been carried out by the Pharmacovigilance Risk Assessment Committee (PRAC), the Committee responsible for the evaluation of safety issues for human medicines, which made a set of recommendations.
Pregled je opravil Odbor za oceno tveganja na področju farmakovigilance (PRAC), ki je odgovoren za presojo varnostnih vprašanj o zdravilih za uporabo v humani medicini, in podal več priporočil.
The evidence did not confirm any differences in risk between products.
Dokazi niso potrdili razlik v tveganju med zdravili.
Corticosteroid inhalers are widely used in the European Union (EU) to treat COPD and pneumonia is a common side effect of such treatment.
Inhalacijski kortikosteroidi se v Evropski uniji (EU) pogosto uporabljajo za zdravljenje KOPB.
The review did not find any conclusive evidence of differences in this risk for different products.
Pregled ni prinesel prepričljivih dokazov o razlikah v tveganju med različnimi zdravili.
Review finds no differences between products in risk of pneumonia
Pregled ni pokazal razlik med zdravili glede tveganja za pljučnico.
There is no conclusive clinical evidence for intra-class differences in the magnitude of the risk among ICS products.
Za razlike med velikostmi tveganja med zdravili iz skupine IKS ni nobenih trdnih kliničnih dokazov.
Both populations received multivitamin supplements.
Obe populaciji sta prejemali multivitaminske dodatke.
It is not known whether these findings translate into long-term clinical benefits.
Ni znano, ali te ugotovitve pomenijo dolgoročno klinično korist.
Diverticulitis.
Divertikulitis.
The capsule should be swallowed with water.
Kapsulo je treba pogoltniti z vodo.
Lack of interactions
Odsotnost interakcij
It has not been demonstrated that the effect on HbA1c is independent from weight reduction.
Ni dokazano, da bi bil vpliv na HbA1c neodvisen od zmanjšanja telesne mase.
Date of latest renewal: 17 June 2008
Datum zadnjega podaljšanja dovoljenja za promet: 17. junij 2008
Therefore orlistat treatment should only be initiated after careful consideration of the possible impact in these patients.
Zdravljenje z orlistatom je treba zato pričeti po skrbnem premisleku glede možnega vpliva na te bolnike.
Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.
Navadno ti simptomi izginejo, če nadaljujete zdravljenje in vzdržujete priporočeno dieto.
4.5 Interaction with other medicinal products and other forms of interaction
4.5 Medsebojno delovanje z drugimi zdravili in druge oblike interakcij Ciklosporin
This can lead to a decrease of immunosuppressive efficacy.
To lahko zmanjša imunosupresivno učinkovitost.
Do not take a double dose.
Odmerka ne smete podvojiti.
• Medicines to treat HIV.
• zdravil za zdravljenje okužbe s HIV;
The undigested fat cannot be absorbed and is eliminated by your body.
Neprebavljena maščoba se ne more absorbirati in se iz telesa izloči.
You may ask your doctor for advice.
Za nasvet povprašajte zdravnika;
In patients receiving amiodarone treatment, the clinical relevance of this effect remains unknown but may become clinically relevant in some cases.
Pri bolnikih, ki jemljejo amiodaron, klinični pomen tega učinka še ni znan, lahko pa postane klinično pomemben v nekaterih primerih.
Xenical has been studied in long-term clinical studies of up to 4 years duration.
Zdravilo Xenical so preskušali v dolgotrajnih kliničnih študijah, ki so potekale do 4 let.
This is important as using more than one medicine at the same time can strengthen or weaken the effects of the medicines.
To je pomembno, ker se lahko med hkratnim jemanjem več zdravil poveča ali zmanjša njihov učinek.
Xenical with food and drink
Zdravilo Xenical skupaj s hrano in pijačo
Please contact your doctor if you think that the frequency and/or severity of the convulsions have changed when taking Xenical together with antiepileptic drugs.
Prosimo, obrnite se na svojega zdravnika, če menite, da se je pogostost in/ali resnost konvulzij spremenila, ko ste sočasno jemali zdravilo Xenical in antiepileptike.
Upper respiratory infection Lower respiratory infection
okužba zgornjih dihal okužba spodnjih dihal
These symptoms are generally mild, occur at the beginning of treatment and are particularly experienced after meals containing high levels of fat.
Ti simptomi so navadno blagi, pojavijo se na začetku zdravljenja in so še posebej izraženi po obrokih, ki vsebujejo veliko maščob.
• The active substance is orlistat.
• Zdravilna učinkovina je orlistat.
Increase in liver transaminases and in alkaline phosphatase.
Povečanje vrednosti jetrnih transaminaz in alkalne fosfataze.
• Iodine salts and/or levothyroxine.
• jodovih soli in/ali levotiroksina.
See Chapter 2, take special care with Xenical.
Glejte poglavje 2, Bodite posebno pozorni pri jemanju zdravila Xenical.
The volume of distribution cannot be determined because the drug is minimally absorbed and has no defined systemic pharmacokinetics.
Porazdelitvenega volumna ni mogoče določiti, ker se absorbira le neznatna količina zdravila, in ker nima opredeljene sistemske farmakokinetike.
• if you have chronic malabsorption syndrome (insufficient absorption of nutrients from alimentary tract),
• če imate kronični malabsorpcijski sindrom (nezadostna absorpcija hranil iz prebavil),
Approximately 97 % of the administered dose was excreted in faeces and 83 % of that as unchanged orlistat.
Približno 97 % vnesenega odmerka se izloči z blatom, od tega 83 % kot nespremenjen orlistat.
Therefore the combination is not recommended (see section 4.4).
Kombinacije zato ne priporočamo (glejte poglavje 4.4).
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 29 July 1998
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum pridobitve dovoljenja za promet: 29. julij 1998
Ciclosporin blood levels should be monitored until stabilised.
Koncentracije ciklosporina v krvi je treba spremljati, dokler se ne uravnovesijo.
Skin blistering (including blisters that burst).
Kožni mehurji (vključno z mehurji, ki pokajo).
The absence of these interactions has been demonstrated in specific drug-drug-interaction studies.
Odsotnost teh interakcij so dokazali v specifičnih interakcijskih študijah zdravilo-zdravilo.
Xenical reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. You should therefore follow your doctor's advice in taking a well balanced diet rich in fruit and vegetables.
Zdravilo Xenical zmanjša absorpcijo pripravkov nekaterih v maščobi topnih hranil, zlasti beta karotena in vitamina E, zato morate upoštevati zdravnikov nasvet o uravnovešeni prehrani z veliko sadja in zelenjave.
The primary endpoint was the change in body mass index (BMI) from baseline to the end of the study.
Primarni cilj študije je bila sprememba v indeksu telesne mase (ITM) od začetka do zaključka študije.
Common side effects (affects 1 to 10 users in 100)
Pogosti neželeni učinki (prizadenejo 1 do 10 od 100 uporabnikov)
Increases in the levels of some liver enzymes may be found in blood tests.
Zvišana raven nekaterih jetrnih encimov pri krvnih testih.
The reason for this difference is that the five 2-year studies included a 4-week diet and placebo lead-in period during which patients lost on average 2.6 kg prior to commencing treatment.
Razlog za to je razlika, da je pet 2 leti trajajočih študij vključevalo uvajalno obdobje 4 tednov diete in placeba, v katerem so bolniki v povprečju izgubili 2,6 kg pred začetkom zdravljenja.
This means you will usually take one capsule at breakfast time, one capsule at lunch time and one capsule at dinner time.
To pomeni, da boste običajno vzeli trikrat po eno kapsulo (pri zajtrku, kosilu in večerji).
The vast majority of patients receiving up to four full years of treatment with orlistat in clinical studies had vitamin A, D, E and K and beta-carotene levels that stayed within normal range.
V kliničnih študijah je velika večina bolnikov, ki so se zdravili z orlistatom do štirih let, imela ravni vitaminov A, D, E in K ter beta karotena v normalnem območju.
Inform your doctor whether you suffer from problems with your kidney.
Zdravniku povejte, če imate težave z ledvicami.
Doses of orlistat above 120 mg three times daily have not been shown to provide additional benefit.
Odmerki orlistata, večji od 120 mg trikrat na dan, niso pokazali dodatne terapevtske koristi.
Xenical attaches to the enzymes in your digestive system (lipases) and blocks them from breaking down some of the fat you have eaten during your meal.
Zdravilo Xenical se veže na encime v prebavnem sistemu (lipaze) in jim prepreči, da bi razgradili nekaj maščobe, ki ste jo zaužili med obrokom.
The results were significantly superior in the orlistat group (difference in BMI of 0.86 kg/m2 in favour of orlistat).
Rezultati so bili signifikantno boljši v skupini, ki je prejemala orlistat (razlika v ITM za 0,86 kg/m2 v prid orlistatu).
Do not change the prescribed dose yourself unless your doctor tells you to.
Odmerka ne spreminjajte, če vam tega ni svetoval zdravnik.
This leaflet was last revised in <{MM/YYYY}> <{month YYYY}>.
Navodilo je bilo nazadnje revidirano {MM/LLLL}.
• Medicines for depression, psychiatric disorders or anxiousness
• zdravil za zdravljenje depresije, psihiatričnih bolezni in tesnobe.
Some fatal cases or cases requiring liver transplantation have been reported.
ki so se končali s smrtjo ali primerih, ki so zahtevali presaditev jeter.
If you forget to take your medicine at any time, take it as soon as you remember provided this is within one hour of your last meal, then continue to take it at the usual times.
Če ste pozabili vzeti zdravilo, ga vzemite takoj, ko se spomnite, če od zadnjega obroka hrane ni preteklo več kot eno uro.
The use of orlistat may be associated with renal stones in patients suffering from chronic kidney disease.
Uporaba orlistata je lahko povezana z nastankom ledvičnih kamnov pri bolnikih, ki imajo kronično ledvično bolezen.
Other medicines and Xenical
Druga zdravila in zdravilo Xenical
To gain optimal benefit, avoid the intake of food containing fat between meals, such as biscuits, chocolate and savoury snacks.
Učinek zdravila je najboljši, če med glavnimi obroki ne uživate živil, ki vsebujejo maščobe, kot so piškoti, čokolada in drugi prigrizki.
Your doctor may need to monitor your ciclosporin blood levels more frequently than usual.
Vaš zdravnik bo zato mogoče po potrebi opravil več meritev ravni ciklosporina v krvi kot ponavadi;
For orlistat no clinical data on exposed pregnancies are available.
Klinični podatki nosečnic, ki so bile izpostavljene orlistatu, niso na voljo.
Upon discontinuation of therapy, faecal fat content usually returns to pre-treatment levels, within 48 to 72 hours.
Po končanem zdravljenju se vsebnost maščobe v blatu običajno v 48 do 72 urah povrne na vrednosti pred zdravljenjem.
What Xenical is and what it is used for What you need to know before you take Xenical How to take Xenical
Kaj je zdravilo Xenical in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Xenical Kako jemati zdravilo Xenical
If you take more capsules than you have been told to take, or if someone else accidentally takes your medicine, contact a doctor, pharmacist or hospital as you may need medical attention.
Če ste vzeli večji odmerek zdravila Xenical, kot bi smeli Če ste vzeli več kapsul, kot vam je predpisal zdravnik, ali je kapsule nenamerno zaužila tretja oseba, se posvetujte z zdravnikom, farmacevtom ali pokličite v bolnišnico, ker boste morda potrebovali medicinsko pomoč.
• if you have cholestasis (liver disorder)
• če imate holestazo (motnjo jetrnega delovanja),
Symptoms can include yellowing skin and eyes, itching, dark coloured urine, stomach pain and liver tenderness (indicated by pain under the front of the rib cage on your right hand side), sometimes with loss of appetite.
Simptomi lahko vključujejo porumenelost kože in oči, srbenje, temno obarvan urin, bolečino v trebuhu in otrdela jetra (pojavi se bolečina pod sprednjim delom reber na vaši desni strani), včasih je prisotna tudi izguba teka.
An additional contraceptive method is recommended in case of severe diarrhoea (see section 4.4).
Dodatna kontracepcijska metoda je priporočljiva v primeru hude driske (glejte poglavje 4.4).
Rare occurrence of hypothyroidism and/or reduced control of hypothyroidism may occur.
Redko se lahko pojavi hipotiroidizem in/ali zmanjšana kontrola hipotiroidizma.
Patients should be advised to adhere to the dietary recommendations they are given (see section 4.2).
Bolnikom svetujemo, naj upoštevajo dietna navodila (glejte poglavje 4.2).
Contents of the pack and other information What XENICAL contains
Vsebina pakiranja in dodatne informacije Kaj vsebuje zdravilo Xenical
INFORMATION IN BRAILLE xenical
PODATKI V BRAILLOVI PISAVI xenical
PHARMACEUTICAL FORM AND CONTENTS 21 hard capsules
FARMACEVTSKA OBLIKA IN VSEBINA 21 trdih kapsul
The recommended dose of orlistat is one 120 mg capsule taken with water immediately before, during or up to one hour after each main meal.
Odrasli Priporočeni odmerek orlistata je ena 120-mg kapsula, ki naj jo bolnik vzame z vodo tik pred ali med vsakim glavnim obrokom ali do eno uro po njem.
84 hard capsules
84 trdih kapsul
M1 and M3 have an open beta-lactone ring and extremely weak lipase inhibitory activity (1000 and 2500 fold less than orlistat respectively).
M1 in M3 imata odprt betalaktonski obroč in skrajno šibak zaviralni učinek na lipazo (1000- oziroma 2500-krat šibkejši od orlistata).
This risk is increased in patients with underlying chronic kidney disease and/or volume depletion (see section 4.8).
To tveganje je večje pri bolnikih s kronično ledvično boleznijo in/ali izgubo tekočine (glejte poglavje 4.8).
However, orlistat may indirectly reduce the availability of oral contraceptives and lead to unexpected pregnancies in some individual cases.
Orlistat lahko posredno zmanjša razpoložljivost peroralnih kontraceptivov, kar lahko v posameznih primerih pripelje do nenačrtovane nosečnosti.
Xenical may modify the activity of
Zdravilo Xenical lahko spremeni delovanje:
Please inform your doctor or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed.
Obvestite svojega zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
Treatment with orlistat may potentially impair the absorption of fat-soluble vitamins (A, D, E and K).
Zdravljenje z orlistatom lahko potencialno vpliva na absorpcijo vitaminov, topnih v maščobah (A, D,
If you forget to take XENICAL
Če ste pozabili vzeti zdravilo Xenical
Children Xenical is not intended to be used in children.
Otroci Zdravilo Xenical ni namenjeno zdravljenju otrok.
Based on human and animal studies, any systemic effects attributable to the lipase-inhibiting properties of orlistat should be rapidly reversible.
Izsledki študij pri človeku in živalih kažejo, da morebitni sistemski zaviralni učinki na lipaze, ki jih lahko pripišemo orlistatu, hitro izzvenijo.
42 hard capsules
42 trdih kapsul
It is recommended that the diet should be rich in fruit and vegetables.
Priporočljivo je, da prehrana vsebuje veliko sadja in zelenjave.
In vitro orlistat is > 99 % bound to plasma proteins (lipoproteins and albumin were the major binding proteins).
In vitro se več kot 99 % orlistata veže na beljakovine v plazmi (pretežno na lipoproteine in albumin).
Common: Fatigue
Pogosti: utrujenost
The usual dose of Xenical is one 120 mg capsule taken with each of the three main meals per day.
Običajen odmerek zdravila Xenical je ena 120-mg kapsula ob vsakem od treh glavnih dnevnih obrokov hrane.
You must not breast-feed your infant during treatment with Xenical as it is not known whether Xenical passes into human milk.
Med zdravljenjem z zdravilom Xenical svojega otroka ne smete dojiti, ker ni znano, ali zdravilo prehaja v materino mleko.
The majority of orlistat overdose cases received during post-marketing reported either no adverse events or adverse events that are similar to those reported with recommended dose.
Pri večini primerov prevelikega odmerjanja orlistata, ki so jih opazili v času trženja zdravila, niso poročali o neželenih učinkih ali pa so bili podobni učinkom pri priporočenem odmerjanju.
Very common: Influenza General disorders and administration site conditions
Zelo pogosti: influenca Splošne težave in spremembe na mestu aplikacije
Taking Xenical during pregnancy is not recommended.
Nosečnost in dojenje Jemanje zdravila Xenical med nosečnostjo ni priporočljivo.
The effect of orlistat results in an increase in faecal fat as early as 24 to 48 hours after dosing.
Učinek orlistata se kaže kot zvečanje maščob v blatu in je viden že 24 do 48 ur po jemanju.
As it is not known whether orlistat is secreted into human milk, orlistat is contra-indicated during breast-feeding.
Ni znano, ali orlistat pri ljudeh prehaja v mleko, zato je jemanje orlistata med dojenjem kontraindicirano.
Orlistat minimally partitions into erythrocytes.
Nekaj orlistata prehaja v eritrocite.
Xenical is indicated in the treatment of obesity in conjunction with a low calorie intake diet.
Zdravilo Xenical je indicirano za zdravljenje debelosti ob hkratni nizkokalorični dieti.
The absence of an interaction between oral contraceptives and orlistat has been demonstrated in specific drug-drug interaction studies.
Odsotnost interakcij med peroralnimi kontraceptivi in orlistatom so dokazali v specifičnih interakcijskih študijah zdravilo-zdravilo.
To gain the maximum benefit from Xenical you should follow the nutrition program recommended to you by your doctor.
Da bi bilo zdravilo Xenical čim učinkovitejše, morate natančno upoštevati navodila o načrtovani prehrani, ki vam jo priporoči zdravnik.
The patient should be on a nutritionally balanced, mildly hypocaloric diet that contains approximately 30 % of calories from fat.
Bolnik mora med zdravljenjem uživati uravnovešeno, zmerno nizkokalorično prehrano, v kateri znaša kalorični delež maščob približno 30 %.
Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) and very rare (<1/10,000) including isolated reports.
(≥ 1/1000, < 1/100), redki (≥ 1/10.000, < 1/1000) in zelo redki (< 1/10.000), vključno s posameznimi primeri.
The effect of orlistat in patients with hepatic and/or renal impairment, children and elderly patients has not been studied.
Učinek orlistata pri bolnikih z jetrno in/ali ledvično okvaro, pri otrocih, mlajših od 12 let, in pri starejših bolnikih ni bil raziskan.
Co-administration of orlistat with ciclosporin is not recommended (see section 4.5).
Sočasno jemanje orlistata s ciklosporinom ni priporočljivo (glejte poglavje 4.5).
It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine site of the gastric and pancreatic lipases.
Njegov terapevtski učinek v želodcu in tankem črevesu temelji na nastanku kovalentne vezi z aktivnim serinskim mestom želodčnih in pankreasnih lipaz.
Xenical is not recommended for people taking acarbose (an anti-diabetic drug used to treat type 2 diabetes mellitus).
Uporaba zdravila Xenical pri ljudeh, ki jemljejo akarbozo (zdravilo, ki se uporablja pri zdravljenju sladkorne bolezni tipa 2), ni priporočljiva.
In the absence of pharmacokinetic interaction studies, the concomitant administration of orlistat with acarbose should be avoided.
Ker farmakokinetične interakcijske študije niso bile opravljene, se je sočasnemu jemanju orlistata z akarbozo potrebno izogibati.
In clinical trials, the decrease in bodyweight with orlistat treatment was less in type II diabetic patients than in non-diabetic patients.
V kliničnih preskušanjih je bilo ob zdravljenju z orlistatom zmanjšanje telesne mase pri bolnikih s sladkorno boleznijo tipa II manjše kot pri bolnikih brez sladkorne bolezni.
Oxalate nephropathy (build up of calcium oxalate which may lead to kidney stones).
Oksalatna nefropatija (kopičenje kalcijevega oksalata, ki lahko privede do nastanka ledvičnih kamnov).
As with any weight-control program, over-consumption of fat and calories may reduce any weight loss effect.
Tako kot pri vseh shujševalnih programih lahko tudi pri tovrstnem čezmerno uživanje maščob in kalorij učinek zdravila izniči.
If you have missed several doses, please inform your doctor and follow the advice given to you.
Če ste pozabili vzeti več kapsul, obvestite zdravnika in ravnajte po njegovem nasvetu.
A decrease in ciclosporin plasma levels has been observed in a drug-drug-interaction study and also reported in several cases, when orlistat was administered concomitantly.
Zmanjšanje plazemske koncentracije ciklosporina so opazili v interakcijski študiji zdravilo-zdravilo, o tem pa so poročali tudi v nekaj primerih, ko so sočasno dajali orlistat.
Xenical can be taken immediately before, during a meal or up to one hour after a meal.
Zdravilo Xenical lahko vzamete tik pred obrokom, med obrokom ali do eno uro po obroku.
In animal reproductive studies, no teratogenic effect was observed.
Pri študijah vpliva na sposobnost za razmnoževanje na živalih teratogenega delovanja niso opazili.
The following table of undesirable effects (first year of treatment) is based on adverse events that occurred at a frequency of > 2 % and with an incidence ≥ 1 % above placebo in clinical trials of 1 and 2 years duration:
Spodnja preglednica neželenih učinkov (prvo leto zdravljenja) prikazuje neželene učinke, ki so se pojavili s pogostnostjo > 2 % in z incidenco ≥ 1 % v primerjavi s placebom v kliničnih preskušanjih,
Co-administration with ciclosporin is not recommended.
Sočasno jemanje s ciklosporinom ni priporočljivo.
The majority of unwanted effects related to the use of Xenical result from its local action in your digestive system.
Vzrok za večino neželenih učinkov zdravila Xenical je njegovo lokalno delovanje v prebavilih.
The incidence of adverse events decreased with prolonged use of orlistat.
Incidenca neželenih učinkov se je z nadaljevanjem zdravljenja z orlistatom zmanjševala.
The difference was driven by the outcome in the group of patients with ≥ 5 % weight loss after 12 weeks of treatment with orlistat representing 19 % of the initial population.
Na razliko je močno vplival rezultat skupine bolnikov z ≥ 5-% izgubo telesne mase po 12 tednih zdravljenja z orlistatom, ki so predstavljali 19 % prvotne populacije.