natgillin/translations-raw huggingface dataset:
Plasma clearance decreases markedly at high doses; it falls from approximately 40 l/kg/day at the dose of 600 mg/day to about 8 l/kg/day at the dose of 2,400 mg. Clearance is decreased after repeated administration of stiripentol, probably due to inhibition of the cytochrome P450 isoenzymes responsible for its metabolism.
Pri velikih odmerkih se plazemski očistek zelo zmanjša; pade iz približno 40 l/kg/dan pri odmerku 600 mg/dan na približno 8 l/kg/dan pri odmerku 2.400 mg. Očistek se zmanjša po ponavljajočem dajanju stiripentola, verjetno zaradi zaviranja izoencimov citokroma P450, ki so odgovorni za presnovo stiripentola.
Growth rate of children
Hitrost rasti otroka
Stiripentol potentiates the efficacy of other anticonvulsants, such as carbamazepine, sodium valproate, phenytoin, phenobarbital and many benzodiazepines, as the result of pharmacokinetic interactions.
Stiripentol zveča učinkovitost ostalih antikonvulzivov (npr. karbamazepina, natrijevega valproata, fenitoina, fenobarbitala in številnih benzodiazepinov) kot posledica farmakokinetičnih interakcij.
As a result, no pharmacokinetic metabolic drug interaction between stiripentol and levetiracetam is anticipated.
Posledično ne pričakujemo farmakokinetične presnovne interakcije med stiripentolom in levetiracetamom.
In rodent models, stiripentol appears to increase brain levels of gamma-aminobutyric acid (GABA) - the major inhibitory neurotransmitter in mammalian brain.
Pri podganah stiripentol zviša ravni gama-aminomaslene kisline (GABA) v možganih, ki je poglavitni inhibitorni nevrotransmiter v možganih sesalcev.
No data on exposed pregnancies are available.
Ni na voljo podatkov od nosečnic, ki so bile izpostavljene zdravilu.
If you have the impression that the effect of this medicine is too strong or too weak, talk to your child's doctor or pharmacist.
Če menite, da je učinek zdravila Diacomit premočan ali prešibak, se posvetujte z otrokovim zdravnikom ali farmacevtom.
How to take the Diacomit capsules
Kako jemati zdravilo Diacomit kapsule
Increased risk of dose-dependent adverse reactions such as rhabdomyolysis (decreased hepatic metabolism of cholesterol-lowering medicinal product).
Povečano tveganje neželenih učinkov, ki so odvisni od odmerka, npr. rabdomioliza (zmanjšana jetrna presnova zdravil za znižanje ravni holesterola).
Likewise, the effect of stiripentol on their metabolism is not known.
Podobno tudi ni poznan vpliv stiripentola na njihovo presnovo.
Your child should always take these capsules exactly as your child's doctor has told you.
Vaš otrok mora jemati te kapsule natančno po navodilih otrokovega zdravnika.
For these children the use of stiripentol will be done under the close supervision of the doctor.
Uporaba stiripentola pri teh otrocih poteka pod skrbnim zdravnikovim nadzorom.
The pivotal clinical studies did not include children below 3 years old.
V ključne klinične študije zdravila Diacomit niso bili vključeni otroci, mlajši od 3 let.
In the event of an abnormal blood count or liver function test finding, the clinical decision for continuing use or adjusting the dose of stiripentol in conjunction with adjusting the doses of clobazam and valproate needs to be made on an individual patient basis taking into consideration the potential clinical benefits and risks (see section 4.4).
Če je rezultat krvne slike ali preiskave jetrne funkcije nenormalen, mora biti klinična odločitev o nadaljevanju uporabe oz. prilagoditvi odmerka stiripentola in odmerkov klobazama ter valproata sprejeta glede na posameznega bolnika ob upoštevanju potencialnih koristnih učinkov in tveganj (glejte poglavje 4.4).
Biocodex, 1 avenue Blaise Pascal - F-60000 Beauvais - France
Biocodex, 1 avenue Blaise Pascal - F-60000 Beauvais - Francija
• hyperkinesis (exaggerated movements);
• hiperkinezija (čezmerni gibi);
Stiripentol is an inhibitor of the enzymes CYP2C19, CYP3A4 and CYP2D6 and may markedly increase the plasma concentrations of substances metabolised by these enzymes and increase the risk of adverse reactions (see section 4.5).
Stiripentol je zaviralec encimov CYP2C19 in CYP3A4 in CYP2D6 ter lahko bistveno zviša plazemske koncentracije zdravil, ki se presnavljajo preko teh dveh encimov lahko poveča tveganje neželenih učinkov (glejte poglavje 4.5).
The most common side effects with stiripentol are anorexia, weight loss, insomnia, drowsiness, ataxia, hypotonia and dystonia.
Najpogostejši neželeni učinki stiripentola so anoreksija, zmanjšanje telesne mase, nespečnost, zaspanost, ataksija, hipotonija in distonija.
What you need to know before your child takes Diacomit
Kaj morate vedeti, preden bo vaš otrok vzel zdravilo Diacomit
• double vision when used in combination with the antiepileptic medicine carbamazepine;
• dvojni vid, če se zdravilo Diacomit uporabi v kombinaciji s karbamazepinom (zdravilom proti epilepsiji);
This medicine contains less than 1 mmol sodium (23 mg) per sachet, that is to say essentially ‘sodium-free'.
To zdravilo vsebuje manj kot 1 mmol (23 mg) natrija na vrečico, kar v bistvu pomeni »brez natrija«.
Systemic exposure to stiripentol increases markedly compared to dose proportionality.
Sistemska izpostavljenost stiripentolu se povečuje veliko hitreje kot sorazmerno z odmerkom.
Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, foetal development, parturition or postnatal development at non-maternotoxic doses (see section 5.3).
Študije na živalih za odmerke, ki niso toksični za brejo samico, ne kažejo neposrednih ali posrednih škodljivih vplivov na nosečnost, razvoj plodu, porod ali postnatalni razvoj (glejte poglavje 5.3).
60 sachets
60 vrečic
Data are limited about the use of stiripentol under 12 months of age.
Podatki o uporabi stiripentola pri otrocih, mlajših od 12 mesecev, so omejeni.
Undesirable combinations (to be avoided unless strictly necessary) - Rye ergot alkaloids (ergotamine, dihydroergotamine) Ergotism with possibility of necrosis of the extremities (inhibition of hepatic elimination of rye ergot).
Neželene kombinacije (kombinacije, ki se jim je treba izogniti, če ni absolutno nujno) - Alkaloidi rženega rožička (ergotamin, dihidroergotamin) Ergotizem z možno nekrozo okončin (zaviranje izločanja alkaloidov rženega rožička preko jeter).
11121 Prague 1
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It should always be taken in combination with clobazam and valproate under the direction of a doctor.
To zdravilo mora otrok vedno jemati v kombinaciji s klobazomom in valproatiom po navodilih zdravnika.
Increased plasma benzodiazepine levels may occur via decreased hepatic metabolism leading to excessive sedation.
Zaradi zmanjšane presnove v jetrih lahko pride do zvišanih plazemskih koncentracij benzodiazepina, kar povzroči prekomerno sedacijo.
90 sachets
90 vrečic
It is used in conjunction with clobazam and valproate (other antiepileptic medicines) to treat a certain form of epilepsy called severe myoclonic epilepsy in infancy (Dravet's syndrome), which affects children.
Uporablja se sočasno s klobazamom in valproatom (drugi zdravili proti epilepsiji) za zdravljenje posebne oblike epilepsije, ki jo imenujemo huda mioklonična epilepsija v otroštvu (Dravetov sindrom).
Raised γ-GT
Preiskave zvišane ravni γ-GT
Stiripentol powder for oral suspension in sachet contains aspartame, a source of phenylalanine.
Stiripentol v obliki praška za peroralno suspenzijo v vrečici vsebuje aspartam, ki je vir fenilalanina.
In the absence of human studies on excretion in breast milk, and given that stiripentol passes freely from plasma into milk in the goat, breast-feeding is not recommended during treatment.
Študije o izločanju v materino mleko pri ljudeh niso bile opravljene, vendar stiripentol prosto prehaja iz plazme v mleko pri kozah, zato dojenje med zdravljenjem ni priporočljivo.
Potential medicinal product interactions affecting stiripentol
Možne interakcije, ki vplivajo na stiripentol
The hard capsules are supplied in plastic bottles containing 30, 60 or 90 capsules in cardboard cartons.
Trde kapsule so pakirane v plastenke s 30, 60 ali 90 kapsulami.
This medicine contains sorbitol: 2.4 mg in each 250mg-sachet and 4.8 mg in each 500mg-sachet.
To zdravilo vsebuje sorbitol: 2,4 mg v vsaki 250-mg vrečici in 4,8 mg v vsaki 500-mg vrečici.
Studies in the rat on fertility and general reproductive performance and on pre- and postnatal development were uneventful except for a minor reduction in the survival of pups nursed by mothers exhibiting toxic responses to stiripentol at a dose of 800 mg/kg/day (see section 4.6).
Pri podganah študije plodnosti, splošne sposobnosti razmnoževanja ter prenatalnega in postnatalnega razvoja niso pokazale učinkov, razen manjšega zmanjšanja preživetja mladičev, ki so jih dojile samice s toksičnim odzivom na stiripentol v odmerku 800 mg/kg/dan (glejte poglavje 4.6).
Stiripentol, the active ingredient of Diacomit, belongs to a group of medicines called antiepileptics.
Zdravilo Diacomit, ki vsebuje učinkovino stiripentol, spada v skupino antiepileptikov.
• rash, skin allergy, urticaria (pinkish, itchy swellings on the skin);
• izpuščaj, kožna alergija, urtikarija (rožnata, srbeča oteklina na koži);
Based on the clinical observations in this group of patients, there is no evidence to suggest that a change in topiramate dose and dosage schedules is needed if coadministered with stiripentol.
Pri kliničnem opazovanju v tej skupini bolnikov niso našli dokazov za spremembo odmerka topamirata oz. načrta odmerjanja pri sočasnem dajanju s stiripentolom.
As a consequence, it is recommended that children between 6 months and 3 years of age are carefully monitored whilst on Diacomit therapy.
Zato je priporočljivo natančno spremljanje otrok, starih od 6 mesecev do 3 let, ki se zdravijo z zdravilom Diacomit.
The initiation of adjunctive therapy with stiripentol should be undertaken gradually using upwards dose escalation to reach the recommended dose of 50 mg/kg/day administered in conjunction with clobazam and valproate.
Dopolnilno zdravljenje s stiripentolom uvajate postopno tako, da odmerke počasi večate do priporočene vrednosti, tj. 50 mg/kg/dan, skupaj z klobazamom in valproatom.
The second effect of stiripentol is mainly based on metabolic inhibition of several isoenzymes, in particular CYP450 3A4 and 2C19, involved in the hepatic metabolism of other anti-epileptic medicines.
Drugi učinek stiripentola temelji predvsem na presnovnem zaviranju več izoencimov, zlasti CYP450 3A4 in 2C19, ki sodelujeta pri presnovi drugih zdravil proti epilepsiji v jetrih.
Despite the absence of comprehensive pharmacology data on potential drug interactions, the following advice regarding modification of the dose and dosage schedules of other anti-epileptic medicinal products administered in conjunction with stiripentol is provided based on clinical experience.
Čeprav ni obsežnih farmakoloških podatkov o možnih interakcijah zdravila, so na osnovi kliničnih izkušenj predlagani naslednji ukrepi za spremembo odmerkov in načrtov odmerjanja drugih zdravil proti epilepsiji, ki se uporabljajo sočasno s stiripentolom.
Inhibition of CYP450 isoenzyme CYP2C19 and CYP3A4 may provoke pharmacokinetic interactions (inhibition of their hepatic metabolism) with phenobarbital, primidone, phenytoin, carbamazepine, clobazam (see section 4.2), valproate (see section 4.2), diazepam (enhanced myorelaxation), ethosuximide, and tiagabine.
Zaviranje CYP450 izoencimov CYP2C19 in CYP3A4 lahko povzroči farmakokinetične interakcije (zaviranje njihove presnove v jetrih) s fenobarbitalom, primidonom, fenitoinom, karbamazepinom, klobazamom (glejte poglavje 4.2), valproatom (glejte poglavje 4.2), diazepamom (povečana miorelaksacija), etosuksimidom in tiagabinom.
These capsules should be swallowed whole with water.
Kapsule je treba pogoltniti cele z vodo.
At therapeutic concentrations, stiripentol significantly inhibits several CYP450 isoenzymes: for example, CYP2C19, CYP2D6 and CYP3A4.
V terapevtskih koncentracijah stiripentol znatno zavira več izoencimov CYP450: na primer CYP2C19, CYP2D6 in CYP3A4.
Size 0, white capsule
trde kapsule bele kapsule velikosti 0
Stiripentol should not be taken with milk or dairy products (yoghurt, soft cream cheese, etc.), carbonated drinks, fruit juice or food and drinks that contain caffeine or theophylline.
Stiripentol se ne sme jemati z mlekom ali mlečnimi izdelki (jogurt, sir za mazanje itn.), gaziranimi pijačami, sadnim sokom ali živili in pijačami, ki vsebujejo kofein ali teofilin.
B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (see Annex I: Summary of Product Characteristics, section 4.2).
Predpisovanje in izdaja zdravila je le s posebnim režimom (glejte PrilogoI: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
• raised levels of liver enzymes, especially when given with either of the antiepileptic medicines carbamazepine and sodium valproate;
• zvišane ravni jetrnih encimov, zlasti pri sočasnem dajanju s karbamazepinom ali natrijevim valproatom - zdraviloma proti epilepsiji;
• if your child is allergic to stiripentol or to any of the other ingredients of Diacomit (listed in section 6).
• če je vaš otrok alergičen na stiripentol ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
• abnormal liver function test.
• nenormalne vrednosti jetrnih testov.
The daily dosage of clobazam and/or valproate should be reduced according to the onset of side effects whilst on stiripentol therapy (see section 4.2).
Dnevno odmerjanje klobazama ali valproata ali obojega je treba znižati, če se pojavijo neželeni učinki med zdravljenjem s stiripentolom (glejte poglavje 4.2).
Boxes of 30, 60 and 90 sachets.
Škatle s 30, 60 in 90 vrečicami.
Povidone (K29/32) Sodium starch glycolate (type A) Magnesium stearate
Povidon (K29/32) Natrijev karboksimetilškrob (tip A) Magnezijev stearat
Diacomit contains aspartame, glucose, sorbitol and sodium This medicine contains 2.5 mg aspartame in each 250mg-sachet and 5 mg each 500mg-sachet.
Diacomit vsebuje aspartam, glukozo, sorbitol in natrij To zdravilo vsebuje 2,5 mg aspartama v vsaki 250-mg vrečici in 5 mg v vsaki 500-mg vrečici.Aspartam je vir fenilalanina.
• Because of the frequency of gastrointestinal side effects with Diacomit, clobazam and valproate, such as anorexia, loss of appetite, vomiting, your child's growth rate should be carefully monitored.
• zaradi pogostnosti gastrointestinalnih neželenih učinkov zdravila Diacomit, klobazama in valproata, kot so anoreksija, izguba apetita in bruhanje, je treba skrbno spremljati hitrost rasti otroka.
Most stiripentol is excreted via the kidney.
Večina stiripentola se izloči preko ledvic.
The clinical decision for use of Diacomit in children with SMEI less than 3 years of age needs to be made on an individual patient basis taking into consideration the potential clinical benefits and risks (see section 4.2).
Klinična odločitev za uporabo zdravila Diacomit pri otrocih s SMEI, ki so mlajši od 3 let, mora biti sprejeta glede na posameznega bolnika ob upoštevanju potencialnih koristnih učinkov in tveganj (glejte poglavje 4.2).
The clinical decision for use of stiripentol in pregnancy needs to be made on an individual patient basis taking into consideration the potential clinical benefits and risks.
Klinična odločitev za uporabo stiripentola med nosečnostjo mora biti sprejeta glede na posamezno bolnico ob upoštevanju potencialnih koristnih učinkov in tveganj.
Aggressiveness, irritability, behaviour disorders, opposing behaviour, hyperexcitability, sleep disorders
Psihiatrične motnje nespečnost agresivnost, razdražljivost, vedenjske motnje, nasprotujoče obnašanje, hiperekscitabilnost, motnje spanja
Capsule core
Notranjost kapsul
For the interaction of stiripentol with food, see section 4.5.
Za informacije o interakcijah stiripentola s hrano glejte poglavje 4.5.
• The capsule shell is made of gelatine, titanium dioxide (E171).
• Ovojnica kapsule je izdelana iz želatine in titanovega dioksida (E171).
Do NOT take Diacomit with milk or dairy products (yoghurt, soft cream cheeses, etc), fruit juice, fizzy drinks or food and drinks that contain caffeine or theophylline (for example cola, chocolate, coffee, tea and energy drinks).
Jemanje zdravila Diacomit skupaj s hrano in pijačo Zdravila Diacomit NE jemljite z mlekom in mlečnimi izdelki (jogurti, siri za mazanje itd), sadnim sokom, gaziranimi pijačami ali živili in pijačami, ki vsebujejo kofein ali teofilin (npr. kola, čokolada, kava, čaj in energijski napitki).
• if your child has ever experienced attacks of delirium (a mental state with confusion,
• če je vaš otrok kdaj imel napade delirija (duševno stanje zmedenosti, vznemirjenosti, nemira in halucinacij).
As a consequence, it is recommended that children between 6 months and 3 years of age are carefully monitored whilst on stiripentol therapy.
Zato je priporočljivo natančno spremljanje otrok, starih od 6 mesecev do 3 let, ki se zdravijo stiripentolom.
- If you have any further questions, ask your child's doctor or pharmacist.
- Če imate dodatna vprašanja, se posvetujte z otrokovim zdravnikom ali farmacevtom.
Titanium dioxide (E171) Erythrosine (E127) Indigotine (E132)
Titanov dioksid (E 171) Eritrozin (E127) Indigotin (E132)
Anorexia, loss of appetite, weight loss
Presnovne in prehranske motnje anoreksija, izguba apetita, zmanjšanje telesne mase
Each sachet contains 5 mg of aspartame, 1,000 mg of glucose liquid spray and 4.8 mg of sorbitol.
Vsaka vrečica vsebuje 5 mg aspartama, 1000 mg glukoze, pripravljene z razprševalnim sušenjem, in 4,8 mg sorbitola.
Stiripentol is not recommended for use in patients with impaired hepatic and/or renal function (see section 4.4).
Uporaba stiripentola ni priporočljiva pri bolnikih z okvarjenim delovanjem jeter ali ledvic ali obojim (glejte poglavje 4.4).
If you have any further questions on the use of this product, ask your child's doctor or pharmacist.
Če imate dodatna vprašanja o uporabi zdravila, se posvetujte z otrokovim zdravnikom ali s farmacevtom.
• The other ingredients of the capsule are povidone K29/32, sodium starch glycolate type A and magnesium stearate.
• Pomožne snovi v kapsuli so: povidon K29/32, natrijev karboksimetilškrob tipa A in magnezijev stearat.
These substances should not be used in conjunction with stiripentol in the management of Dravet's syndrome.
Teh snovi se pri obravnavi Dravetovega sindroma ne sme uporabiti sočasno s stiripentolom.
The clinical decision for use of stiripentol in children with SMEI less than 3 years of age needs to be made on an individual patient basis taking into consideration the potential clinical benefits and risks.
Klinična odločitev za uporabo stiripentola pri otrocih s SMEI, ki so mlajši od 3 let, mora biti sprejeta glede na posameznega bolnika ob upoštevanju potencialnih koristnih učinkov in tveganj.
Your child should always take the contents of each sachet exactly as your child's doctor has told you.
Vaš otrok mora vzeti vsebino vrečice natančno po navodilih otrokovega zdravnika.
Levetiracetam does not undergo hepatic metabolism to a major extent.
Levetiracetam se večinoma ne presnavlja v jetrih.
- Effects on other antiepileptic drugs (AEDs)
- Učinki na druga zdravila proti epilepsiji
Biocodex,7 avenue Gallieni - F-94250 Gentilly - France Tel: + 33 1 41 24 30 00 - e-mail: webar@biocodex.fr
Biocodex, 7 avenue Gallieni - F-94250 Gentilly - Francija Tel: + 33 1 41 24 30 00 - E-pošta: webar@biocodex.fr
Blood and lymphatic system disorders
Bolezni krvi in limfatičnega sistema nevtropenija trombocitopenija*
- Immunosuppressants (tacrolimus, cyclosporine, sirolimus) Raised blood levels of immunosuppressants (decreased hepatic metabolism).
Zdravila za zaviranje imunske odzivnosti (takrolimus, ciklosporin, sirolimus) Zvišane koncentracije zdravil za zaviranje imunske odzivnosti v krvi (zmanjšana presnova v jetrih).
The pivotal clinical evaluation of stiripentol was in children of 3 years of age and over with SMEI.
Ključne raziskave uporabe stiripentola so bile opravljene pri otrocih starih 3 leta in več, ki so imeli SMEI.
Given the frequency of gastrointestinal adverse reactions to treatment with stiripentol and valproate (anorexia, loss of appetite, nausea, vomiting), the growth rate of children under this combination of treatment should be carefully monitored.
Glede na pogostnost gastrointestinalnih neželenih učinkov pri zdravljenju s stiripentolom in valproatom (anoreksija, izguba apetita, navzea, bruhanje) je treba ob uporabi omenjene kombinacije zdravljenja skrbno spremljati hitrost rasti otroka.
This warning is not only restricted to medicinal products but also to a considerable number of foods and nutritional products aimed at children: Patient should not drink cola drinks, which contain significant quantities of caffeine or chocolate, which contains trace amounts of theophylline (see section 4.2).
Bolnik ne sme uživati pijače kole, ki vsebuje znatne količine kofeina, ali čokolade, ki vsebuje sledove teofilina (glejte poglavje 4.2).
Size 2 pink capsule
trde kapsule rožnate kapsule velikosti 2
Diacomit is indicated for use in conjunction with clobazam and valproate as adjunctive therapy of refractory generalized tonic-clonic seizures in patients with severe myoclonic epilepsy in infancy (SMEI, Dravet's syndrome) whose seizures are not adequately controlled with clobazam and valproate.
Zdravilo Diacomit se uporablja skupaj s klobazamom in valproatom kot dodatno zdravljenje neodzivnih generaliziranih tonično-kloničnih napadov pri bolnikih s hudo mioklonično epilepsijo v otroštvu (SMEI - severe myoclonic epilepsy in infancy, Dravetov sindrom), kadar krčev ne moremo zadostno nadzorovati s klobazamom in valproatom.
• Your child's liver function should be assessed prior to starting Diacomit and checked every 6
• pred začetkom jemanja zdravila Diacomit je treba pri otroku pregledati delovanje jeter in ga preverjati vsakih 6 mesecev,
Your child must not stop taking this medicine unless the doctor tells you to.
Če je vaš otrok prenehali jemati zdravilo Diacomit Vaš otrok ne sme prenehati jemati tega zdravila, če tega ne naroči zdravnik.
0.11 mg sodium per sachet.
0,11 mg natrija v vsaki vrečici.
• Your child's blood count should be assessed prior to starting Diacomit and checked every 6
• pred začetkom jemanja zdravila Diacomit je treba pregledati otrokovo krvno sliko in jo preverjati vsakih 6 mesecev,
In case of switch between capsule and powder formulation it should be done under the close supervision of the doctor.
Zamenjava kapsul s praškom mora potekati pod strogim nadzorom zdravnika.
• nausea, vomiting;
• slabost, bruhanje;
The population estimate for the absorption rate constant Ka was 2.08 hr-1 (standard deviation of random effect = 122%).
Populacijska ocena za konstanto hitrosti absorpcije Ka je bila 2,08 ur
The impact of macrolides and azole antifungal medicinal products on stiripentol metabolism, that are known to be inhibitors of CYP3A4 and substrates of the same enzyme, is not known.
Vpliv makrolidov in azolnih protiglivičnih zdravil, ki so znani zaviralci CYP3A4 in substrati tega encima, na presnovo stiripentola ni znan.
0.22 mg sodium per sachet.
0,22 mg natrija v vsaki vrečici.
Please consult your child's doctor in the event of any side effects as the doctor may have to adjust the dose of this medicine and the other antiepileptic medicine(s).
Če se pojavijo neželeni učinki, se posvetujte z otrokovim zdravnikom, saj bo morda prilagodil odmerek zdravila Diacomit in drugih zdravil proti epilepsiji.
Caution should be exercised when prescribing to pregnant women and use of efficient methods of contraception is advisable.
Pri predpisovanju zdravila nosečnicam je potrebna previdnost.
7 avenue Gallieni 94250 Gentilly France
7 avenue Gallieni 94250 Gentilly Francija
What Diacomit 500 mg looks like and contents of the pack Diacomit 500 mg hard capsules are white.
Izgled zdravila Diacomit 500 mg in vsebina pakiranja Diacomit 500 mg trde kapsule so bele barve.
In vitro studies suggested that stiripentol phase 1 metabolism is catalyzed by CYP1A2, CYP2C19 and CYP3A4 and possibly other enzymes.
In vitro študije so nakazale, da so pri 1. fazi stiripentol metabolizma katalizatorji CYP1A2, CYP2C19, CYP3A4 in verjetno drugi encimi.
Tel: + 33 1 41 24 30 00 e-mail: webar@biocodex.fr
Tel: + 33 1 41 24 30 00 E-pošta: webar@biocodex.fr