natgillin/translations-raw huggingface dataset:
When Seroquel XR administered once daily is compared to the same total daily dose of immediate-release quetiapine fumarate (Seroquel immediate release) administered twice daily, the area under the plasma concentration-time curve (AUC) is equivalent, but the maximum plasma concentration (Cmax) is 13% lower at steady state.
Če primerjamo uporabo zdravila Seroquel SR enkrat na dan z enakim celotnim dnevnim odmerkom kvetiapinijevega fumarata s takojšnjim sproščanjem (zdravilo Seroquel), uporabljenim dvakrat na dan, je površina pod krivuljo koncentracije v plazmi po času (AUC)
Overdose could lead to QT-prolongation, seizures, status epilepticus, rhabdomyolysis, respiratory depression, urinary retention, confusion, delirium and/or agitation, coma and death.
Preveliko odmerjanje lahko vodi do podaljšanja intervala QT, konvulzij, statusa epilepticusa, rabdomiolize, depresije dihanja,
Seroquel can be administered with or without food.
Zdravilo Seroquel lahko bolniki jemljejo s hrano ali brez.
Depression in bipolar disorder is associated with an increased risk of suicidal thoughts, self-harm and suicide (suicide-related events).
Samomor/samomorilne misli ali klinično poslabšanje: Depresija je povezana z večjim tveganjem za pojav samomorilnih misli, samopoškodovanja in samomorilnosti (s samomorom povezani dogodki).
• Increase in the amount of a hormone called prolactin, in the blood.
• zvišanje koncentracije hormona, imenovanega prolaktin, v krvi.
Do not take Seroquel XR if you are taking any of the following medicines:
Ne jemljite zdravila Seroquel SR, če jemljete katero od naštetih zdravil:
Seroquel data in combination with divalproex or lithium in acute moderate to severe manic episodes at 3 and 6 weeks is limited; however, combination therapy was well tolerated.
Podatki o uporabi zdravila Seroquel v kombinaciji z valproatom ali litijem pri zdravljenju akutnih zmernih do hudih maničnih epizod po 3 in 6 tednih so omejeni; kombinirano zdravljenje pa so bolniki dobro prenašali.
The mean quetiapine plasma clearance decreases with approximately 25% in persons with known hepatic impairment (stable alcoholcirrhosis).
Povprečni plazemski očistek kvetiapina se pri bolnikih z znano okvaro jeter (stabilna alkoholna ciroza) zmanjša za približno 25 %.
Somnolence and dizziness:
Zaspanost in omotica:
Prolactin levels (patients < 18 years of age): >20 ug/L (>869.56 pmol/L) males; >26 ug/L (>1130.428 pmol/L) females at any time.
Koncentracija prolaktina (bolniki, stari < 18 let): > 20 µg/l (> 869,56 pmol/l) moški, > 26 µg/l (> 1130,428 pmol/l) ženske kadarkoli.
Based on clinical trial adverse event reports of blood creatine phosphokinase increase not associated with neuroleptic malignant syndrome 15.
Zvišanje krvnih vrednosti kreatin fosfokinaze, ki ni povezana z malignim nevroleptičnim sindromom.
Longer term relapse prevention trials had an open label period (ranging from 4 to 36 weeks) during which patients were treated with quetiapine, followed by a randomized withdrawal period during which patients were randomized to quetiapine or placebo.
36 tednov); med odprtim obdobjem so bolniki prejemali kvetiapin, sledilo pa je randomizirano obdobje odtegnitve, med katerim so bolnike randomizirali na kvetiapin ali placebo.
Elevations in serum triglyceride levels 10,30
Presnovne in prehranske motnje zvišanje koncentracije trigliceridov v serumu 10,30
Cytochrome P450 (CYP) 3A4 is the enzyme that is primarily responsible for the cytochrome P450 mediated metabolism of quetiapine.
Citokrom P450 (CYP) 3A4 je encim, ki je primarno odgovoren za presnovo kvetiapina s citokromom
(22) Decreased haemoglobin to ≤13 g/dL (8.07 mmol/L) males, ≤12 g/dL (7.45 mmol/L) females on at least one occasion occurred in 11% of quetiapine patients in all trials including open label extensions.
(21) Glejte poglavje 5.1 (22) Znižanje hemoglobina na ≤ 13 g/dl (8,07 mmol/l) pri moških in ≤ 12 g/dl (7,45 mmol/l) pri ženskah se je vsaj enkrat pojavilo pri 11% bolnikov, ki so prejemali kvetiapin v vseh preskušanjih vključno z odprtimi deli preizkušanj.
(See section 4.4).
(glejte poglavje 4.4).
Elevations in total cholesterol (predominantly LDL cholesterol) Decreases in HDL cholesterol 17,30,
Presnovne in prehranske motnje zvišanje koncentracije trigliceridov v serumu zvišanje celotnega holesterola (pretežno holesterola LDL) znižanje holesterola HDL 17,30,
• A combination of high temperature (fever), sweating, stiff muscles, feeling very drowsy or faint (a disorder called “neuroleptic malignant syndrome).”
• kombinacija zvišane telesne temperature (vročina), znojenja, togih mišic, občutka hude zaspanosti ali omedlevice (to motnjo imenujemo »nevroleptični maligni sindrom«),
Seroquel tablets contain lactose.
Tablete zdravila Seroquel vsebujejo laktozo.
(6) Fasting blood glucose ≥126 mg/dL(≥7.0 mmol/L) or a non fasting blood glucose ≥200 mg/dL (≥11.1 mmol/L) on at least one occasion.
(6) Glukoza v krvi na tešče ≥ 126 mg/dl (≥7,0 mmol/l) ali glukoza v krvi, ki ni izmerjena na tešče, ≥ 200 mg/dl (≥11,1 mmol/l) vsaj enkrat.
The total daily dose for the first four days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4).
Skupni dnevni odmerki prve štiri dni zdravljenja so 50 mg (1. dan), 100 mg (2. dan), 200 mg (3. dan) in 300 mg (4. dan).
The dose can be increased in increments of 50 mg/day to an effective dose, depending on the clinical response and tolerability of the individual patient.
Odmerek je mogoče povečevati po 50 mg/dan do učinkovitega odmerka, odvisno od bolnikovega individualnega kliničnega odziva in prenašanja.
It is also not recommended to consume grapefruit juice while on quetiapine therapy.
Prav tako med zdravljenjem s kvetiapinom ni priporočljivo piti grenivkinega soka.
• A serious blistering condition of the skin, mouth, eyes and genitals (Stevens-Johnson syndrome)
• resne kožne reakcije z mehurjastimi izpuščaji na koži, ustih, očeh in genitalijah (Stevens
In short-term, placebo-controlled clinical trials in schizophrenia and bipolar mania the aggregated incidence of extrapyramidal symptoms was similar to placebo (schizophrenia: 7.8% for quetiapine and 8.0% for placebo; bipolar mania: 11.2% for quetiapine and 11.4% for placebo).
Klinična varnost V kratkotrajnih, s placebom kontroliranih kliničnih preskušanjih pri shizofreniji in bipolarni maniji je bila skupna incidenca ekstrapiramidnih simptomov podobna kot pri placebu (shizofrenija: 7,8 % s kvetiapinom, 8,0 % s placebom; bipolarna manija: 11,2 % s kvetiapinom in 11,4 % s placebom).
The same precautions observed when treating patients with major depressive episodes should therefore be observed when treating patients with other psychiatric disorders.
Zato je treba pri zdravljenju drugih psihiatričnih motenj upoštevati enake previdnostne ukrepe kot pri zdravljenju velikih depresivnih epizod.
Constipation and intestinal obstruction have been reported with quetiapine (see section 4.8 Undesirable effects).
Med uporabo kvetiapina sta bili opisani zaprtost in zapora črevesa (glejte poglavje 4.8 Neželeni učinki).
Seizure 1, Restless legs syndrome, Tardive dyskinesia 1, 5,
dizartrija konvulzije 1, sindrom nemirnih nog, zapoznela (tardivna) diskinezija 1,
However in two 10-week placebocontrolled quetiapine studies in the same patient population (n=710); mean age: 83 years; range: 56-99 years) the incidence of mortality in quetiapine treated patients was 5.5% versus 3.2% in the placebo group.
Toda v dveh 10tedenskih s placebom kontroliranih študijah kvetiapina pri isti populaciji bolnikov (n = 710, povprečna starost 83 let, razpon 56-99 let) je bila incidenca umrljivosti med prejemniki kvetiapina 5,5 % in v skupini s placebom 3,2 %.
• Do not drink grapefruit juice while you are taking Seroquel.
• Ne pijte grenivkinega soka medtem, ko se zdravite z zdravilom Seroquel.
In rats, pigment deposition in the thyroid gland has been observed; in cynomolgus monkeys thyroid follicular cell hypertrophy, a lowering in plasma T3 levels, decreased haemoglobin concentration and a decrease of red and white blood cell count have been observed; and in dogs lens opacity and cataracts.
Pri opicah vrste Cynomolgus so opazili hipertrofijo folikularnih celic ščitnice, znižanje koncentracije T3 v plazmi, znižanje koncentracije hemoglobina ter zmanjšanje števila eritrocitov in levkocitov.
(11) Cholesterol ≥240 mg/dL (≥6.2064 mmol/L) (patients ≥18 years of age) or ≥200 mg/dL (≥5.172 mmol/L) (patients <18 years of age) on at least one occasion.
(11) Holesterol ≥ 240 mg/dl (≥ 6,2064 mmol/l) (bolniki, stari ≥ 18 let) ali ≥ 200 mg/dl (≥ 5,172 mmol/l) (bolniki, stari < 18 let) vsaj v enem primeru.
(4) As with other antipsychotics with alpha1 adrenergic blocking activity, quetiapine may commonly induce orthostatic hypotension, associated with dizziness, tachycardia and, in some patients, syncope, especially during the initial dose-titration period.
(4) Tako kot druga antipsihotična zdravila, ki delujejo tudi kot blokatorji adrenergičnih receptorjev alfa1, tudi kvetiapin pogosto povzroči ortostatsko hipotenzijo, ki je povezana z omotico, tahikardijo in pri nekaterih bolnikih s sinkopo.
For patients who were randomized to quetiapine, the mean weight gain during the open label period was 2.56 kg, and by week 48 of the randomized period, the mean weight gain was 3.22 kg, compared to open label baseline.
randomiziranih na kvetiapin, je bilo povprečno povečanje telesne mase med odprtim obdobjem 2,56 kg, do 48. tedna randomiziranega obdobja pa je bilo povprečno povečanje telesne mase 3,22 kg v primerjavi z izhodiščem odprtega obdobja.
Concomitant administration of cytochrome P450 3A4 inhibitors, such as HIV-protease inhibitors, azoleantifungal agents, erythromycin, clarithromycin and nefazodone, is contraindicated.
Kontradicirana je sočasna uporaba z zaviralci citokroma P450 3A4, kot so zaviralci proteaz HIV, protiglivična zdravila iz skupine azolov, eritromicin, klaritromicin in nefazodon (glejte tudi poglavje
If it is almost time to take the next dose, wait until then.
Če ste pozabili vzeti odmerek, ga vzemite, čim se spomnite, razen, če je že skoraj čas za naslednjo tableto, v tem primeru počakajte do takrat.
In a clinical trial to evaluate the cataractogenic potential of Seroquel (200-800 mg/day) versus risperidone (2-8 mg/day) in patients with schizophrenia or schizoaffective disorder, the percentage of patients with increased lens opacity grade was not higher in Seroquel (4%) compared with risperidone (10%), for patients with at least 21 months of exposure.
Katarakte/zamotnitev očesne leče V kliničnih preskušanjih, kjer so ocenjevali vpliv zdravila Seroquel (200-800 mg/dan) na nastanek katarakte, v primerjavi z risperidonom (2-8 mg/dan) pri bolnikih s shizofrenijo ali shizofrenimi motnjami, odstotek bolnikov s povečano stopnjo motnosti očesne leče, pri zdravilu Seroquel ni bil višji (4%) v primerjavi z risperidonom (10 %) pri bolnikih, ki so zdravilo prejemali vsaj 21 mesecev.
• You have diabetes or have a risk of getting diabetes.
• ste kdaj doživeli napad krčev (konvulzije), • imate sladkorno bolezen ali pa povečano tveganje za nastanek sladkorne bolezni.
• If you are allergic (hypersensitive) to quetiapine or any of the other ingredients of Seroquel (see section 6: Further information)
• če ste alergični na (preobčutljivi za) kvetiapin ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
Seroquel XR dose can be adjusted depending on clinical response and tolerability of the individual patient within the dose range of 300 mg to 800 mg/day.
Odmerek zdravila Seroquel SR je mogoče prilagoditi glede na klinični odziv in prenašanje posameznega bolnika v razponu od 300 do 800 mg/dan.
No data is available about the incidence of seizures in patients with a history of seizure disorder.
Podatkov o incidenci konvulzij pri bolnikih z anamnezo konvulzivne motnje ni.
• Yellowing of the skin and eyes (jaundice).
• porumenelost kože in očesnih beločnic (zlatenica),
In post-marketing, QT prolongation was reported with quetiapine at the therapeutic doses (see Section 4.8) and in overdose (see Section 4.9).
V obdobju po prihodu zdravila na trg so ugotovili podaljšanje QT pri terapevtskih odmerkih (glejte poglavje 4.8) in pri prevelikem odmerjanju (glejte poglavje 4.9).
Treatment with quetiapine should be reassessed in patients with suspected cardiomyopathy or myocarditis.
Pri bolnikih s sumom na kardiomiopatijo ali miokarditis je treba zdravljenje s kvetiapinom ponovno pretehtati.
Quetiapine is well absorbed following oral administration.
Kvetiapin se po peroralni uporabi dobro absorbira.
(7) An increase in the rate of dysphagia with quetiapine vs. placebo was only observed in the clinical trials in bipolar depression.
(7) Pogostejše pojavljanje disfagije med uporabo kvetiapina v primerjavi s placebom so zabeležili samo v kliničnih preskušanjih pri bipolarni depresiji.
Not known (frequency cannot be estimated from the available data)
Neznana pogostnost: pogostnosti iz razpoložljivih podatkov ni mogoče oceniti • kožni izpuščaj z nepravilnimi rdečimi pikami po koži (multiformni eritem),
If you are having a urine drug screen, taking Seroquel may cause positive results for methadone or certain drugs for depression called tricyclic antidepressants (TCAs) when some test methods are used, even though you may not be taking methadone or TCAs.
Če vam bodo pregledali urin za določanje vsebnosti zdravil, lahko jemanje zdravila Seroquel povzroči lažno pozitivne rezultate za metadon ali zdravila za zdravljenje depresije imenovana triciklični antidepresivi.
(9) The following withdrawal symptoms have been observed most frequently in acute placebo-controlled, monotherapy clinical trials, which evaluated discontinuation symptoms: insomnia, nausea, headache, diarrhoea, vomiting,
(9) V akutnem, s placebom kontroliranem preskušanju (monoterapija), kateri je ocenjeval odtegnitvene simptome, so opazili naslednje odtegnitvene simptome: nespečnost, slabost, glavobol, diarejo,
• Do not split, chew or crush the tablets.
• Tablet s podaljšanim sproščanjem ne lomite, ne žvečite in ne drobite.
In a 6-week, randomised, study of lithium and SEROQUEL XR versus placebo and SEROQUEL XR in adult patients with acute mania, the difference in YMRS mean improvement between the lithium add-on group and the placebo add-on group was 2.8 points and the difference in % responders (defined as 50% improvement from baseline on the YMRS) was 11% (79% in the lithium add-on group vs. 68% in the placebo add-on group).
Seroquel SR, pri odraslih bolnikih z akutno manijo, je bila razlika v povprečnem izboljšanju po lestvici YMRS med skupino z dodatkom litija in skupino z dodatkom placeba 2,8 točke, razlika v odstotku odzivnih bolnikov (odzivnost je bila opredeljena kot 50 % izboljšanje v primerjavi z izhodiščnim YMRS) pa je bila 11 % (79 % v skupini z dodatkom litija in 68 % v skupini z dodatkom placeba).
With respect to weight gain, when adjusting for normal growth over the longer term, an increase of at least 0.5 standard deviation from baseline in Body Mass Index (BMI) was used as a measure of a clinically significant change; 18.3% of patients who were treated with quetiapine for at least 26 weeks met this criterion.
Kar zadeva povečanje telesne mase, je bila v primeru korekcije za normalno rast v daljšem obdobju kot mera klinično pomembne spremembe uporabljeno povečanje za vsaj 0,5 standardnega odklona od izhodiščnega indeksa telesne mase (ITM);
somnolence headache, Extrapyramidal symptoms1, 21
zaspanost glavobol, ekstrapiramidn i simptomi1, 21
In controlled clinical trials there was no difference in the incidence of seizures in patients treated with quetiapine or placebo.
V kontroliranih kliničnih preskušanjih se incidenca konvulzij med prejemniki kvetiapina in placeba ni razlikovala.
• Take your tablets without food (at least one hour before a meal or at bedtime, your doctor will tell you when.
• Ne jemljite tablet s podaljšanim sproščanjem sočasno s hrano (vzemite jih vsaj eno uro pred obrokom ali pred spanjem.
In shorter-term placebo controlled clinical studies of patients with major depressive episodes in bipolar disorder an increased risk of suicide-related events was observed in young adult patients (younger than 25 years of age) who were treated with quetiapine as compared to those treated with placebo (3.0% vs. 0%, respectively).
V kratkotrajnih s placebom kontroliranih kliničnih študijah bolnikov s hudimi obdobji depresije pri bipolarni motnji so ugotovili večje tveganje s samomorom povezanih dogodkov pri mladih odraslih bolnikih (mlajših od 25 let), ki so prejemali kvetiapin (3,0 %), kot pri tistih, ki so prejemali placebo
Quetiapine was administered twice-daily totalling 400 mg to 800 mg a day as combination therapy to lithium or valproate.
Kvetiapin so uporabljali dvakrat na dan v skupnem odmerku od 400 do 800 mg na dan, kot kombinirano terapijo z litijem ali valproatom.
What Seroquel XR is and what it is used for What you need to know before you take Seroquel XR How to take Seroquel XR
Kaj je zdravilo Seroquel SR in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Seroquel SR Kako jemati zdravilo Seroquel SR
A fever, flu-like symptoms, sore throat, or any other infection, as this could be a result of a very low white blood cell count, which may require Seroquel XR to be stopped and/or treatment to be given.
• zvišano telesno temperaturo, gripi podobne simptome, vneto žrelo ali kakšno drugo okužbo, kajti to je lahko posledica zelo majhnega števila belih krvnih celic; morda boste morali nehati jemati zdravilo Seroquel SR in/ali boste potrebovali zdravljenje.
Day 1
Preglednica 1
Drug withdrawal syndrome neonatal31
puerperija in perinatalnem obdobju neonatalni odtegnitveni sindrom31
A meta analysis of placebo controlled clinical trials of antidepressant drugs in adult patients with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo in patients less than 25 years old.
Metaanaliza s placebom nadzorovanih kliničnih preskušanj antidepresivov pri odraslih bolnikih s psihiatričnimi motnjami je pokazala, da pri bolnikih, mlajših od 25 let, pri uporabi antidepresivov obstaja večje tveganje za pojav samomorilnega vedenja kot pri uporabi placeba.
In vitro investigations established that CYP3A4 is the primary enzyme responsible for cytochrome P450 mediated metabolism of quetiapine.
Raziskave in vitro kažejo, da je CYP3A4 glavni encim, odgovoren za presnovo kvetiapina s citokromom P450.
QT prolongation 1,12
QT 1,12, 18
Do not take Seroquel XR if the above applies to you.
Ne jemljite zdravila Seroquel SR, če kaj od zgoraj naštetega velja za vas.
Do not take Seroquel if the above applies to you.
Ne jemljite zdravila Seroquel, če kaj od zgoraj naštetega velja za vas.
A fever, flu-like symptoms, sore throat, or any other infection, as this could be a result of a very low white blood cell count, which may require Seroquel to be stopped and/or treatment to be given.
• zvišano telesno temperaturo, gripi podobne simptome, vneto žrelo ali kakšno drugo okužbo, kajti to je lahko posledica zelo majhnega števila belih krvnih celic; morda boste morali nehati jemati zdravilo Seroquel in/ali boste potrebovali zdravljenje.
Quetiapine treatment was associated with dose-related decreases in thyroid hormone levels.
Zdravljenje s kvetiapinom je bilo povezano z odmerkom, povezanim znižanjem koncentracije ščitničnih hormonov.
QT Prolongation
Podaljšanje intervala QT
• Epilepsy medicines (like phenytoin or carbamazepine).
• zdravila za zdravljenje epilepsije (kot sta fenitoin ali karbamazepin), • zdravila za zdravljenje visokega krvnega tlaka,
If you forget to take a dose of Seroquel
Če ste pozabili vzeti zdravilo Seroquel
The dose may be adjusted depending on clinical response and tolerability of the individual patient, within the range of 300 to 800 mg/day administered twice daily.
Odmerek je mogoče prilagoditi glede na klinični odziv in prenašanje posameznega bolnika v razponu od 300 do 800 mg/dan dvakrat dnevno.
• Difficulty in passing urine.
• težave pri požiranju,
Withdrawal (dis continuation) symptoms 1,9
Splošne težave in spremembe na mestu aplikacije odtegnitveni (prekinitveni) simptomi 1,9
Read all of this leaflet carefully before you start taking this medicine.
Pred začetkom jemanja zdravila natančno preberite navodilo, ker vsebuje za vas pomembne podatke!
o For the treatment of moderate to severe manic episodes in bipolar disorder o For the treatment of major depressive episodes in bipolar disorder o For the prevention of recurrence of manic or depressed episodes in patients with bipolar disorder who previously responded to quetiapine treatment.
o za zdravljenje zmernih do hudih maničnih epizod pri bipolarni motnji o za zdravljenje velikih depresivnih epizod pri bipolarni motnji o za preprečevanje ponavljanja epizod manije ali depresije pri bolnikih z bipolarno motnjo,
The pharmacokinetics of lithium were not altered when co-administered with quetiapine.
Farmakokinetika litija se pri sočasnem jemanju s kvetiapinom ne spremeni.
(3) Asymptomatic elevations (shift from normal to > 3X ULN at any time) in serum transaminase (ALT, AST) or gamma-GT-levels have been observed in some patients administered quetiapine.
(3) Pri nekaterih bolnikih, ki so dobivali kvetiapin, so opazili asimptomatsko zvišanje (premik od običajnega do > 3X ULN kadarkoli) serumskih transaminaz (ALT, AST) ali gama-GT.
Seroquel was administered twice-daily totalling 400 mg to 800 mg a day as combination therapy to lithium or valproate.
Zdravilo Seroquel so uporabljali dvakrat na dan v skupnem odmerku od 400 do 800 mg na dan, kot kombinirano terapijo z litijem ali valproatom.
Switching from Seroquel immediate-release tablets:
Prehod z zdravila Seroquel filmsko obložene tablete:
The mean plasma clearance of quetiapine was reduced by 30% to 50% in elderly patients when compared to younger patients.
Povprečni plazemski očistek kvetiapina je bil pri starejših bolnikih za 30 do 50 % manjši kot pri mlajših.
6 x 25 mg film-coated tablets 2 x 100 mg film-coated tablets
6 x 25 mg filmsko obloženih tablet 2 x 100 mg filmsko obloženih tablet
What Seroquel XR looks like and contents of the pack
Izgled zdravila Seroquel SR in vsebina pakiranja
The estimated risks of relapse after 6 months treatments was 14.3% for the Seroquel XR treatment group compared to 68.2% for placebo.
Ocenjeno tveganje recidiva po 6 mesecih zdravljenja je bilo 14,3 % v skupini, ki je dobivala zdravilo Seroquel SR, in
Increases in triglycerides, LDL and total cholesterol, and decreases in HDL cholesterol have been observed in clinical trials with quetiapine (see section 4.8).
V kliničnih preskušanjih s kvetiapinom so opazili porast trigliceridov, LDL in celokupnega holesterola ter znižanje HDL (glejte poglavje 4.8).
(10) Triglycerides ≥200 mg/dL (≥2.258 mmol/L) (patients ≥18 years of age) or ≥150 mg/dL (≥1.694 mmol/L) (patients
(10) Trigliceridi ≥ 200 mg/dl (≥ 2,258 mmol/l) (bolniki, stari ≥ 18 let) ali ≥ 150 mg/dl (≥ 1,694
• Constipation, upset stomach (indigestion).
• zaprtost, težave z želodcem (slaba prebava),
Shifts in eosinophils are defined as >1x 10^9 cells/L at any time.
Premiki so opredeljeni kot zvišanje števila eozinofilcev kadarkoli > 1 x 10
6 blisters of 10 tablets 12 blisters of 5 tablets
6 pretisnih omotov po 10 tablet 12 pretisnih omotov po 5 tablet
In all short-term placebo-controlled monotherapy trials in patients with a baseline neutrophil count ≥1.5 X 109/L, the incidence of at least one occurrence of a shift to neutrophil count <1.5 X 109/L, was 1.9% in patients treated with quetiapine compared to 1.5% in placebo-treated patients.
V vseh kratkotrajnih preskušanjih monoterapije, kontroliranih s placebom, pri bolnikih z izhodiščnim številom nevtrofilcev ≥ 1,5 x 109/l je bila incidenca vsaj ene spremembe števila nevtrofilcev na < 1,5 x 109/l pri bolnikih, zdravljenih s kvetiapinom 1,9 % in 1,5 % pri bolnikih, ki so dobivali placebo.
Interactions See also section 4.5
Medsebojno delovanje Glejte tudi poglavje 4.5.