natgillin/translations-raw huggingface dataset:
Atazanavir and fluconazole concentrations were not significantly modified when atazanavir /ritonavir was coadministered with fluconazole.
Pri sočasni uporabi atazanavirja/ritonavirja in flukonazola se koncentracije atazanavirja in flukonazola niso pomembneje spremenile.
What Atazanavir Krka looks like and contents of the pack Atazanavir Krka 150 mg hard capsules
Izgled zdravila Atazanavir Krka in vsebina pakiranja Atazanavir Krka 150 mg trde kapsule
a Mean baseline CD4 cell count was 214 cells/mm3 (range 2 to 810 cells/mm3) and mean baseline plasma HIV-1 RNA was
a Srednje število celic CD4 v izhodišču je bilo 214 celic/mm3 (razpon od 2 do 810 celic/mm3), srednja vrednost plazemske
During postpartum:
Poporodno obdobje:
Indinavir is also associated with indirect (unconjugated) hyperbilirubinaemia due to inhibition of UGT.
Tudi indinavir je povezan z zvišanjem indirektnega (nekonjugiranega) bilirubina v krvi zaradi zavrtja
shellac black ferric oxide (E172)
šelak črni železov oksid (E172)
↔ Atazanavir ↔ Ritonavir
Atazanavir/ritonavir b
common: rash; uncommon: erythemia multiformea,b, toxic skin eruptionsa,b, drug rash with eosinophilia and systemic symptoms (DRESS) syndrome a,b angioedemaa, urticaria, alopecia, pruritus; rare: Stevens-Johnson syndrome a,b
(DRESS)a,b, angioedema, urtikarija, alopecija, pruritus; redki: Stevens-Johnsonov sindroma,b, vezikobulozen izpuščaj, ekcem,
Voriconazole AUC ↓33% (↓42% Voriconazole cmax ↓10% (↓22% Voriconazole cmin ↓39% (↓49%
Vorikonazol AUC ↓33 % (↓42 % ↓22 %) Vorikonazol Cmax ↓10 % (↓22 % ↓4 %) Vorikonazol Cmin ↓39 % (↓49 % ↓28 %)
Elbasvir 50 mg once daily (atazanavir 300 mg/ ritonavir 100 mg once daily)
Elbasvir 50 mg enkrat na dan (atazanavir 300 mg/ ritonavir 100 mg enkrat na dan)
INFORMATION IN BRAILLE Atazanavir Krka 200 mg
PODATKI V BRAILLOVI PISAVI Atazanavir Krka 200 mg
Atazanavir Krka is an antiviral (or antiretroviral) medicine.
Kaj je zdravilo Atazanavir Krka in za kaj ga uporabljamo Zdravilo Atazanavir Krka je zdravilo, ki deluje proti virusom (ali retrovirusom).
At high doses that lead to high drug exposures, jaundice due to indirect (unconjugated) hyperbilirubinaemia (without associated liver function test changes) or PR interval prolongations may be observed (see sections 4.4 and 4.8).
Pri velikih odmerkih, ki povzročijo veliko izpostavljenost zdravilu, se lahko pojavita zlatenica, ki je posledica indirektne (nekonjugirane) hiperbilirubinemije (brez spremljajočih sprememb testov jetrnih funkcij),
diltiazem, systemic lidocaine, verapamil) - atorvastatin, pravastatin, and fluvastatin (used to lower blood cholesterol) - salmeterol (used to treat asthma) - cyclosporin, tacrolimus, and sirolimus (medicines to decrease the effects of body's immune system) - certain antibiotics (rifabutin, clarithromycin) - ketoconazole, itraconazole, and voriconazole (antifungals) - warfarin (anticoagulant, used to reduce the blood clots) - carbamazepine, phenytoin, phenobarbital, lamotrigine (antiepileptics) - irinotecan (used to treat cancer) - sedative agents (e.g. midazolam administered by injection) - buprenorphine (used to treat opioid addiction and pain).
- atorvastatin, pravastatin in fluvastatin (zdravila za zniževanje holesterola v krvi), - salmeterol (zdravilo za zdravljenje astme), - ciklosporin, takrolimus in sirolimus (zdravila, ki zavirajo imunski sistem), - nekateri antibiotiki (rifabutin, klaritromicin), - ketokonazol, itrakonazol in vorikonazol (antimikotiki),
How to take Atazanavir Krka
Kako jemati zdravilo Atazanavir Krka
The Summary of Product Characteristics for ritonavir must be consulted before initiation of therapy with Atazanavir Krka and ritonavir.
Pred začetkom zdravljenja z zdravilom Atazanavir Krka in ritonavirjem je treba prebrati povzetek glavnih značilnosti ritonavirja.
Treatment- Experienced atazanavir Capsules/ritonavir (300 mg/100 mg once daily) n=25
Zdravljenje bolnikov, ki so že prejemali atazanavir v obliki kapsul/ritonavir (300 mg/100 mg enkrat na dan) n = 25
Based on data obtained with other boosted PIs and ketoconazole, where ketoconazole AUC showed a 3-fold increase, atazanavir /ritonavir is expected to increase ketoconazole or itraconazole concentrations.
Na osnovi podatkov, pridobljenih pri uporabi drugih okrepljenih zaviralcev proteaz in ketokonazola, kjer se je vrednost AUC ketokonazola povečala za
INFORMATION IN BRAILLE Atazanavir Krka 300 mg
PODATKI V BRAILLOVI PISAVI Atazanavir Krka 300 mg
ANTIFUNGALS Ketoconazole 200 mg once daily (atazanavir 400 mg once daily)
Ketokonazol 200 mg enkrat na dan (atazanavir 400 mg enkrat na dan)
Co-administration of Atazanavir Krka with other hormonal contraceptives or oral contraceptives containing progestogens other than norgestimate or norethindrone has not been studied, and therefore should be avoided (see section 4.5).
Sočasne uporabe zdravila Atazanavir Krka z drugimi hormonskimi kontraceptivi ali peroralnimi kontraceptivi, ki vsebujejo druge gestagene kot norgestimat ali noretindron, niso raziskovali.
Co-administration with atazanavir with ritonavir warrants clinical monitoring for sedation and cognitive effects.
Pri sočasni uporabi atazanavirja z ritonavirjem je potreben klinični nadzor
Cmin ng/mLb
Cmin ng/mlb geometrična sredina (KV %)
Atazanavir Krka with ritonavir must not be used in patients with moderate to severe hepatic impairment (see sections 4.3, 4.4 and 5.2).
Zdravila Atazanavir Krka se z ritonavirjem ne sme uporabljati pri bolnikih z zmerno do hudo okvaro jeter (glejte poglavja 4.3, 4.4 in 5.2).
Atazanavir Krka contains lactose monohydrate
Zdravilo Atazanavir Krka vsebuje laktozo monohidrat
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia
IME IN NASLOV IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenija
INFORMATION IN BRAILLE Atazanavir Krka 150 mg
PODATKI V BRAILLOVI PISAVI Atazanavir Krka 150 mg
Atazanavir Krka 150 mg hard capsules
Atazanavir Krka 150 mg trde kapsule
MARKETING AUTHORISATION HOLDER KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia
IMETNIK DOVOLJENJA ZA PROMET Z ZDRAVILOM KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenija
Atazanavir Krka 300 mg hard capsules
Atazanavir Krka 300 mg trde kapsule
PULMONARY ARTERIAL HYPERTENSION PDE5 Inhibitors
Zaviralci PDE5 Sildenafil
Atazanavir Krka is contraindicated in patients with severe hepatic insufficiency (see sections 4.2, 4.4 and 5.2).
Uporaba zdravila Atazanavir Krka je kontraindicirana pri bolnikih s hudo insuficienco jeter (glejte poglavja 4.2, 4.4 in 5.2).
uncommon: nephrolithiasis a, haematuria, proteinuria, pollakiuria, interstitial nephritis; chronic kidney diseasea rare: kidney pain
občasni: nefrolitiazaa, hematurija, proteinurija, polakisurija, intersticijski nefritis, kronična ledvična bolezena; redki: bolečina v ledvicah
Atazanavir Krka 200 mg hard capsules Each hard capsule contains 200 mg atazanavir (as sulphate).
Atazanavir Krka 200 mg trde kapsule Ena trda kapsula vsebuje 200 mg atazanavirja (v obliki sulfata).
HIV RNA <50 copies/ml, % All patientsd
HIV RNA < 50 kopij/ml, % a Vsi bolniki
administered with atazanavir.
Kapsule Atazanavir
When given with atazanavir, the recommended dose of rifabutin is 150 mg 3 times per week on set days (for example MondayWednesday-Friday).
150 mg 3-krat na teden na določene dneve (na primer ponedeljek-sreda-petek).
If the combination of Atazanavir Krka with a proton pump inhibitor is judged unavoidable, close clinical monitoring is recommended in combination with an increase in the dose of Atazanavir Krka to 400 mg with 100 mg of ritonavir; doses of proton pump inhibitors comparable to omeprazole 20 mg should not be exceeded.
Če je sočasna uporaba zdravila Atazanavir Krka in zaviralca protonske črpalke nujna, priporočamo skrben klinični nadzor in povečanje odmerka zdravila Atazanavir Krka na 400 mg skupaj s 100 mg ritonavirja.
293 (n=14b)
293 (n = 14
Co-administration of atazanavir and elbasvir/grazoprevir is contraindicated because of a significant increase in grazoprevir plasma concentrations and an associated potential increase in the risk of ALT elevations (see section
Sočasna uporaba atazanavirja in elbasvirja/grazoprevirja je kontraindicirana zaradi pričakovanega povečanja koncentracij grazoprevirja v plazmi in s tem povezanega možnega večjega tveganja za zvišanje vrednosti ALT (glejte poglavje 4.3).
In HIV-infected adult patients (n=33, combined studies) the mean half-life within a dosing interval for atazanavir was 12 hours at steady state following a dose of 300 mg daily with ritonavir 100 mg once daily with a light meal.
kombinirane študije), je bil srednji razpolovni čas znotraj odmernega intervala atazanavirja v stanju dinamičnega ravnovesja 12 ur po uporabi 300 mg na dan s 100 mg ritonavirja enkrat na dan z lahkim obrokom.
flatulence (wind), dry mouth, abdominal distension - angioedema (severe swelling of the skin and other tissues most often the lips or the eyes) - alopecia (unusual hair loss or thinning), pruritus (itching) - muscle atrophy (muscle shrinkage), arthralgia (joint pain), myalgia (aching muscles)
- angioedem (hudo otekanje kože in drugih tkiv, najpogosteje ustnic ali oči); - alopecija (neobičajno izpadanje ali redčenje las), pruritus (srbenje); - atrofija mišic (zmanjšanje mišične mase), artralgija (bolečina v sklepu), mialgija (bolečine v mišicah); - intersticijski nefritis (vnetje ledvic), hematurija (kri v urinu), proteinurija (presežek beljakovin v urinu), polakisurija (pogostejše uriniranje);
Study 045 is a randomised, multicenter trial comparing atazanavir /ritonavir (300/100 mg once daily) and atazanavir /saquinavir (400/1,200 mg once daily), to lopinavir + ritonavir (400/100 mg fixed dose combination twice daily), each in combination with tenofovir disoproxil (see sections 4.5 and 4.8) and one NRTI, in patients with virologic failure on two or more prior regimens containing at least one PI, NRTI, and NNRTI.
ritonavirjem (400/100 mg v fiksni kombinaciji v odmerku dvakrat na dan), vse v kombinaciji z dizoproksiltenofovirjevim fumaratom (glejte poglavji 4.5 in 4.8) in enim NRTI-jem pri bolnikih z virusnim neodzivom pri dveh ali več predhodnih shemah, ki so obsegale vsaj en zaviralec proteaz, NRTI in NNRTI.
How to store Atazanavir Krka
Shranjevanje zdravila Atazanavir Krka
Table 4.
3- do 4-krat.
Atazanavir Krka 150 mg hard capsules Each hard capsule contains 150 mg atazanavir (as sulphate).
Atazanavir Krka 150 mg trde kapsule Ena trda kapsula vsebuje 150 mg atazanavirja (v obliki sulfata).
300 mg tenofovir disoproxil fumarate is equivalent to 245 mg tenofovir disoproxil
Z dizoproksiltenofovirjevim fumaratom v odmerku 300 mg enkrat na dan (kar ustreza 245 mg dizoproksiltenofovirata)
Atazanavir Krka 300 mg hard capsules Each hard capsule contains 300 mg atazanavir (as sulphate).
Atazanavir Krka 300 mg trde kapsule Ena trda kapsula vsebuje 300 mg atazanavirja (v obliki sulfata).
Norbuprenorphine AUC ↑105% Norbuprenorphine cmax ↑61% Norbuprenorphine cmin ↑101%
Norbuprenorfin AUC ↑105 % Norbuprenorfin Cmax ↑61 % Norbuprenorfin Cmin ↑101 % Mehanizem interakcije je zaviranje CYP3A4 in UGT1A1.
In antiretroviral experienced adult patients
Odrasli bolniki, ki se predhodno še niso zdravili s protiretrovirusnimi zdravili
Due to CYP3A4 inhibition by atazanavir, concentrations of quetiapine are expected to increase.
Pri sočasni uporabi z atazanavirjem se zaradi zavrtja CYP3A4 lahko koncentracije teh imunosupresivov povečajo.
a Atazanavir peak concentrations and AUCs were found to be approximately 26-40% higher during the postpartum period (4
a Najvišje koncentracije atazanavirja in vrednosti AUC so bile po porodu (4-12 tednov) za približno od 26 do 40 % višje od vrednosti, predhodno ugotovljenih pri z virusom HIV okuženih bolnicah, ki niso bile noseče.
Tenofovir disoproxil fumarate 300 mg once daily (atazanavir 300 mg once daily with ritonavir 100 mg once daily)
Dizoproksiltenofovirjev fumarat 300 mg enkrat na dan (atazanavir 300 mg enkrat na dan z ritonavirjem 100 mg enkrat na dan)
For patients who are taking tenofovir disoproxil, if atazanavir/ritonavir with both tenofovir disoproxil and an H2receptor antagonist are coadministered, a dose increase of atazanavir to 400 mg with 100 mg of ritonavir is recommended.
Pri bolnikih, ki se zdravijo z dizoproksiltenofovirat če se sočasno uporablja atazanavir/ritonavir v kombinaciji z obema, dizoproksiltenofoviratom in antagonistom histaminskih receptorjev H2, je priporočljivo, da se odmerek
Hepatic impairment
- glavobol;
Through 96 weeks of treatment, mean HIV RNA changes from baseline for atazanavir + ritonavir and lopinavir + ritonavir met criteria for non-inferiority based on observed cases.
ritonavir in lopinavir + ritonavir zadostile merilom neinferiornosti na podlagi opazovanih primerov.
NAME OF THE MEDICINAL PRODUCT Atazanavir Krka 200 mg hard capsules atazanavir
IME ZDRAVILA Atazanavir Krka 200 mg trde kapsule atazanavir
Hard gelatine capsule (capsule), size no. 1.
Trda želatinasta kapsula (kapsula), velikost št. 1.
Atazanavir Krka capsules must be taken with ritonavir and have to be taken with food.
Krka je treba jemati skupaj z ritonavirjem in skupaj s hrano.
Cap: titanium dioxide (E171), yellow ferric oxide (E172), red ferric oxide (E172), black ferric oxide (E172), gelatine and ink (shellac, titanium dioxide (E171), potassium hydroxide
Kapica: titanov dioksid (E171), rumeni železov oksid (E172), rdeči železov oksid (E172), črni železov oksid (E172), želatina in črnilo (šelak, titanov dioksid (E171), kalijev hidroksid)
Uncommon (may affect up to 1 in 100 people): - peripheral neuropathy (numbness, weakness, tingling or pain in the arms and legs) - hypersensitivity (allergic reaction) - asthenia (unusual tiredness or weakness) - weight decreased, weight gain, anorexia (loss of appetite), appetite increased - depression, anxiety, sleep disorder - disorientation, amnesia (loss of memory), dizziness, somnolence (sleepiness), abnormal dream - syncope (fainting), hypertension (high blood pressure) - dyspnoea (shortness of breath) - pancreatitis (inflammation of the pancreas), gastritis (inflammation of the stomach), stomatitis,
- dezorientiranost, amnezija (izguba spomina), omotica, somnolenca (zaspanost), neobičajne sanje; - sinkopa (omedlevica), hipertenzija (visok krvni tlak); - dispneja (oteženo dihanje); - pankreatitis (vnetje trebušne slinavke), gastritis (vnetje želodca), aftozni stomatitis (razjede in vnetje v ustih), paragevzija (motnje okusa), flatulenca (vetrovi), suha usta, napet trebuh;
If the co-administration of Atazanavir Krka with an NNRTI is required, an increase in the dose of both Atazanavir Krka and ritonavir to 400 mg and 200 mg, respectively, in combination with efavirenz could be considered with close clinical monitoring.
Če je potrebno sočasno zdravljenje z zdravilom Atazanavir Krka in z nenukleozidnim zaviralcem reverzne transkriptaze (NNRTI; “non-nucleoside reverse transcriptase inhibitor”), je v primeru sočasne uporabe efavirenza treba razmisliti o povečanju odmerka zdravila Atazanavir Krka do 400 mg in povečanju odmerka ritonavirja do 200 mg, pri čemer je potreben skrben klinični nadzor.
If an oral contraceptive is administered with atazanavir/ritonavir, it is recommended that the oral contraceptive contain at least 30 μg of ethinyloestradiol and that the patient be reminded of strict compliance with this contraceptive dosing regimen.
Če se peroralni kontraceptiv uporablja skupaj z atazanavirjem/ritonavirjem je priporočljivo, da peroralni kontraceptiv vsebuje vsaj
Patients should not breast-feed while taking Atazanavir Krka.
Bolnice med zdravljenjem z zdravilom Atazanavir Krka ne smejo dojiti.
MARKETING AUTHORISATION NUMBER(S) EU/1/19/1353/003 30 hard capsules EU/1/19/1353/004 90 (3 x 30) hard capsules
EU/1/19/1353/004 90 (3 x 30) trdih kapsul
NAME OF THE MEDICINAL PRODUCT Atazanavir Krka 300 mg hard capsules atazanavir
IME ZDRAVILA Atazanavir Krka 300 mg trde kapsule atazanavir
HDPE tablet container with child-resistant tamper evident PP with desiccant closure: 30 hard capsules and 90 (3 x 30) hard capsules, in a box.
Atazanavir Krka 300 mg trde kapsule Vsebnik za tablete iz HDPE z za otroke varno polipropilensko zaporko s sušilnim sredstvom, ki je ni mogoče odpreti brez vidnih poškodb: 30 trdih kapsul in 90 (3 x 30) trdih kapsul, v škatli.
Atazanavir Krka with ritonavir is contraindicated in patients with moderate hepatic insufficiency (see sections 4.2, 4.4 and 5.2).
Uporaba zdravila Atazanavir Krka z ritonavirjem je kontraindicirana pri bolnikih z zmerno insuficienco jeter (glejte poglavja 4.2, 4.4 in 5.2).
Hard gelatine capsule, size no. 1.
Trda želatinasta kapsula, velikost št. 1.
Treatment-Naive atazanavir Capsules/ritonavir (300 mg/100 mg once daily) n=16
Zdravljenje bolnikov, ki še niso prejemali atazanavirja v obliki kapsul/ritonavirja (300 mg/100 mg enkrat na dan) n = 16
Musculoskeletal and connective tissue disorders uncommon: muscle atrophy, arthralgia, myalgia; rare: myopathy
občasni: atrofija mišic, artralgija, mialgija;
The mechanism of interaction is decreased solubility of atazanavir as intra-gastric pH increases with proton pump inhibitors.
Mehanizem interakcije je zmanjšana topnost atazanavirja zaradi zvišanja vrednosti pH
These are listed under Do not take Atazanavir Krka, at the start of Section 2.
Druga zdravila in zdravilo Atazanavir Krka Zdravila Atazanavir Krka ne smete jemati z nekaterimi drugimi zdravili, ki so navedena na začetku poglavja 2 pod Ne jemljite zdravila Atazanavir Krka.
Atazanavir Krka 200 mg hard capsules
Atazanavir Krka 200 mg trde kapsule
Norethindrone cmax ↑67% (↑42% Norethindrone cmin ↑262%
Noretindron AUC ↑110 % (↑68 % Noretindron Cmax ↑67 % (↑42 % Noretindron Cmin ↑262 % (↑157 %
Based on these data and because ritonavir is not expected to have a significant impact on the pharmacokinetics of NRTIs, the co-administration of these medicinal products and atazanavir is not expected to significantly alter the exposure of the co-administered medicinal products.
NRTI-jev ne pričakujemo, pri sočasni uporabi teh zdravil in atazanavirja ne pričakujemo,
NAME OF THE MEDICINAL PRODUCT Atazanavir Krka 150 mg hard capsules atazanavir
IME ZDRAVILA Atazanavir Krka 150 mg trde kapsule atazanavir
The decrease in AUC, cmax, and cmin was not mitigated when an increased dose of atazanavir /ritonavir (400/100 mg once daily) was temporally separated from omeprazole by 12 hours.
Če so povečan odmerek atazanavirja/ritonavirja (400/100 mg enkrat na dan) začasno ločili od uporabe omeprazola za 12 ur, se zmanjšanje vrednosti AUC, Cmax, in Cmin ni ublažilo.
(atazanavir 300 mg / ritonavir 100 mg once daily)
(atazanavir 300 mg enkrat na dan z ritonavirjem 100 mg enkrat na dan)
b ATV/RTV with tenofovir disoproxil fumarate/emtricitabine (fixed dose 300 mg/200 mg tablets once daily).
b ATV/RTV skupaj s dizoproksiltenofovirijevim fumaratom/emtricitabinom (fiksni odmerek 300 mg/200 mg tablete enkrat na dan).
Interactions with other medicinal products The combination of Atazanavir Krka with atorvastatin is not recommended (see section 4.5).
Zdravila Atazanavir Krka ni priporočljivo uporabljati v kombinaciji z atorvastatinom (glejte poglavje 4.5).
common: jaundice; uncommon: hepatitis, cholelithiasisa, cholestasisa; rare: hepatosplenomegaly, cholecystitis a
občasni: vnetje jeter, holelitiaza a, holestaza a;
Stop taking Atazanavir Krka and talk to your doctor immediately if you develop a severe rash or a rash with flu-like illness symptoms, blisters, fever, mouth sores, muscle or joint pain, swelling in the face, inflammation of the eye which causes redness (conjunctivitis), painful, warm, or red lumps (nodules).
bolečina v mišicah ali sklepih, otekanje obraza, vnetje oči s posledično rdečino oči (konjunktivitis), boleči, topli ali rdeči vozliči (noduli), zdravilo Atazanavir Krka takoj prenehajte jemati in se nemudoma posvetujte z zdravnikom.
Adverse reactions were consistent between patients who received atazanavir 400 mg once daily and patients who received atazanavir 300 mg with ritonavir 100 mg once daily, except that jaundice and elevated total bilirubin levels were reported more frequently with atazanavir plus ritonavir.
Pri bolnikih, ki so prejemali atazanavir v odmerku 400 mg enkrat na dan, in bolnikih, ki so prejemali zdravilo atazanavir v odmerku 300 mg skupaj z ritonavirjem v odmerku 100 mg enkrat na dan, so bili neželeni učinki primerljivi.
Co-administration of salmeterol and Atazanavir Krka is not recommended (see section 4.5).
Sočasna uporaba salmeterola in zdravila Atazanavir Krka ni priporočljiva (glejte poglavje 4.5).
The mechanism of interaction is decreased solubility of atazanavir as intra-gastric pH increases with H2- blockers.
Mehanizem interakcije je zmanjšana topnost atazanavirja zaradi zvišane vrednosti pH želodčnega soka, ki je posledica uporabe antagonista histaminskih receptorjev H2.
** When compared to rifabutin 150 mg once daily alone.
** Pri primerjavi z uporabo samega rifabutina v odmerku 150 mg enkrat na dan. Skupna vrednost AUC rifabutina in
Talk to your doctor immediately if you get dark (tea-colored) urine, itching, yellowing of your skin or the white part of your eyes, pain around the stomach, pale colored stools or nausea.
(barva čaja), srbenja, rumenega obarvanja kože ali očesnih beločnic, bolečine v trebuhu,
blockers like famotidine and proton pump inhibitors like omeprazole) - medicines to lower blood pressure, to slow heart rate, or to correct heart rhythm (amiodarone,
antacidi, ki jih je treba jemati 1 uro pred zdravilom Atazanavir Krka ali 2 uri po zdravilu Atazanavir Krka, antagonisti histaminskih receptorjev H2, kot je famotidin, in zaviralci protonske črpalke, kot je omeprazol), - zdravila za znižanje zvišanega krvnega tlaka, za upočasnitev srčnega utripa ali za uravnavanje srčnega ritma (amiodaron, diltiazem, sistemski lidokain, verapamil),
Difference estimate [95% CI]
[95 % IZ]
c LPV/RTV with tenofovir disoproxil fumarate/emtricitabine (fixed dose 300 mg/200 mg tablets once daily).
c LPV/RTV skupaj s dizoproksiltenofovirijevim fumaratom/emtricitabinom (fiksni odmerek 300 mg/200 mg tablete enkrat na dan).
At the time voriconazole treatment is required, a patient's CYP2C19 genotype should be performed if feasible.
Kadar je potrebno zdravljenje z vorikonazolom, je treba, če je to možno, določiti bolnikov
c Lopinavir/RTV with tenofovir disoproxil fumarate/emtricitabine (fixed dose 300 mg/200 mg tablets once daily).
c Lopinavir/RTV skupaj z dizoproksiltenofovirjevim fumaratom/emtricitabinom (fiksni odmerek 300 mg/200 mg tablete enkrat na dan).
- If tenofovir disoproxil or an H2-receptor antagonist is needed, a dose increase to Atazanavir Krka
Če je uporaba kombinacije nujna, je potreben skrben klinični nadzor, odmerek atazanavirja pa je treba povečati na
Cap: titanium dioxide (E171), yellow ferric oxide (E172), red ferric oxide (E172), gelatine and ink (shellac, black ferric oxide (E172), potassium hydroxide
Kapica: titanov dioksid (E171), rumeni železov oksid (E172), rdeči železov oksid (E172), želatina in črnilo (šelak, črni železov oksid (E172), kalijev hidroksid)
Hard gelatine capsule (capsule), size no. 0.
Trda želatinasta kapsula (kapsula), velikost št. 0.
Capsule shell of Atazanavir Krka 200 mg hard capsules Body: titanium dioxide (E171) yellow ferric oxide (E172) red ferric oxide (E172) gelatine
Ovojnica kapsule - Atazanavir Krka 200 mg trde kapsule Telo: titanov dioksid (E171) rumeni železov oksid (E172)
HCV Protease Inhibitors Boceprevir 800 mg three times daily (atazanavir 300 mg/ritonavir 100 mg once daily)
Zaviralci proteaze HCV Boceprevir 800 mg trikrat na dan (atazanavir
Co-administration of atazanavir and indinavir is not recommended (see section 4.4).
Sočasne uporabe atazanavirja in indinavirja ne priporočamo (glejte poglavje 4.4).
Absorption: in HIV-infected patients (n=33, combined studies), multiple dosing of atazanavir 300 mg once daily with ritonavir 100 mg once daily with food produced a geometric mean (CV%) for atazanavir, cmax of 4466 (42%) ng/ml, with time to cmax of approximately 2.5 hours.
100 mg enkrat na dan skupaj s hrano geometrijska srednja vrednost Cmax (KV %) atazanavirja 4.466 (42 %) ng/ml.