natgillin/translations-raw huggingface dataset:
Therefore, it is recommended to clean and disinfect bird houses where the vaccine was administered after completion of the finishing or rearing period.
Zato se po zakolu živali ali po koncu reje priporoča čiščenje in razkuževanje ptičjih hiš, v katerih je bilo cepivo razpršeno.
When adding Poulvac E. coli to drinking water a sufficient amount to supply one dose of reconstituted vaccine for every chicken should be added to as much water as is consumed by the chickens in three hours.
Kadar se cepivo Poulvac E. coli daje s pitno vodo, mora biti količini vode, ki jo piščanci popijejo v treh urah, dodana takšna količina, da se zagotovi en odmerek pripravljenega cepiva na vsako ptico.
Other information about Poulvac E. coli:
Druge informacije o zdravilu Poulvac E. coli
Why is Poulvac E. coli approved?
Zakaj je bilo zdravilo Poulvac E. coli odobreno?
How does Poulvac E. coli work?
Kako zdravilo Poulvac E. coli deluje?
How is Poulvac E. coli used?
Za kaj se zdravilo Poulvac E. coli uporablja?
MA (EU) number (Invented) name Strength Pharmaceutical Form Route of Administration Immediate Packaging Pack size EU/1/16/1139/001 OCALIVA
Številka EU Zaščiteno ime
Meropenem has been authorised in the EU since the 1990s.
Meropenem je v EU odobren od devetdesetih let prejšnjega stoletja.
Further information on Vabomere can be found on the Agency's website: ema.europa.eu/medicines/human/EPAR/Vabomere.
Več informacij o zdravilu Vabomere je na voljo na spletni strani agencije: ema.europa.eu/medicines/human/EPAR/Vabomere.
Vabomere (meropenem / vaborbactam)
Vabomere (meropenem/vaborbaktam)
What measures are being taken to ensure the safe and effective use of Vabomere?
Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Vabomere?
The Agency decided that Vabomere's benefits are greater than its risks and it can be authorised for use in the EU.
Zaključila je, da so koristi zdravila Vabomere večje od z njim povezanih tveganj in da se lahko odobri za uporabo v EU.
As for all medicines, data on the use of Vabomere are continuously monitored.
Tako kot za vsako zdravilo se tudi podatki o uporabi zdravila Vabomere stalno spremljajo.
Other information about Vabomere
Druge informacije o zdravilu Vabomere
Vabomere was found effective at treating infections in two studies.
Zdravilo Vabomere se je izkazalo za učinkovito pri zdravljenju okužb v dveh študijah.
Why is Vabomere authorised in the EU?
Zakaj je zdravilo Vabomere odobreno v EU?
Side effects reported with Vabomere are carefully evaluated and any necessary action taken to protect patients.
Neželeni učinki, o katerih so poročali pri zdravilu Vabomere, se skrbno ovrednotijo in po potrebi se sprejmejo ukrepi za zaščito bolnikov.
What is Vabomere and what is it used for?
Kaj je zdravilo Vabomere in za kaj se uporablja?
It can also be used for infections caused by Gram-negative bacteria when other treatments might not work.
Uporablja se lahko tudi za zdravljenje okužb, ki jih povzročijo gramnegativne bakterije, kadar druge oblike zdravljenja niso učinkovite.
Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Vabomere have been included in the summary of product characteristics and the package leaflet.
Priporočila in previdnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Vabomere upoštevati zdravstveni delavci in bolniki, so vključeni v povzetek glavnih značilnosti zdravila in navodilo za uporabo.
Tests for bacteria in the urine found that 67% (128 out of 192) of patients treated with Vabomere were cured, compared with 58% (105 out of 182) of patients treated with piperacillin and tazobactam.
Pri testiranju na bakterije v urinu je bilo ugotovljeno, da je bilo ozdravljenih 67 % (128 od 192) bolnikov, ki so bili zdravljeni z zdravilom Vabomere, v primerjavi z 58 % (105 od 182) bolnikov, ki so se zdravili s piperacilinom in tazobaktamom.
What are the risks associated with Vabomere?
Kakšna tveganja so povezana z zdravilom Vabomere?
What benefits of Vabomere have been shown in studies?
Kakšne koristi je zdravilo Vabomere izkazalo v študijah?
The European Medicines Agency noted that there were limited options for treating infections with bacteria that carry beta-lactamases.
Evropska agencija za zdravila je ugotovila, da obstajajo omejene možnosti za zdravljenje okužb z bakterijami, ki prenašajo beta-laktamaze.
An overview of Vabomere and why it is authorised in the EU
Pregled zdravila Vabomere in zakaj je odobreno v EU
It works by interfering with the activity of certain proteins that bacteria need to build their cell walls.
Deluje tako, da ovira delovanje določenih beljakovin, ki jih bakterije potrebujejo za gradnjo svojih celičnih sten.
Fewer patients treated with Vabomere (14%) died within 4 weeks compared with those receiving best available antibiotic treatment (26%).
V štirih tednih je umrlo manj bolnikov, ki so bili zdravljeni z zdravilom Vabomere (14 %), v primerjavi z bolniki, ki so prejeli najboljše razpoložljivo zdravljenje z antibiotiki (26 %).
Vabomere is an antibiotic used in adults to treat the following infections, including when they have spread into the blood (bacteraemia):
Zdravilo Vabomere je antibiotik, ki se uporablja pri odraslih za zdravljenje naslednjih okužb, tudi če so se baterije razširile v kri (bakteriemija):
• complicated abdominal infections of the tissues and organs in the belly (intra-abdominal infections);
• zapletenih okužb tkiv in organov v trebuhu (intraabdominalnih okužb);
This action weakens the bacterial cell walls which can then collapse, ultimately causing the bacteria to die.
S tem oslabi bakterijske celične stene, ki lahko zato propadejo, zaradi česar bakterije sčasoma odmrejo.
The active substances in Vabomere, meropenem and vaborbactam, work in different ways.
Učinkovini zdravila Vabomere, meropenem in vaborbaktam, delujeta na različna načina.
However, the Agency recognised that Vabomere cannot deal with all types of bacteria resistant to meropenem.
Vendar je agencija prepoznala, da zdravilo Vabomere ne more uničiti vseh vrst bakterij, odpornih na meropenem.
Of those treated with Vabomere, overall 60% (21 out of 35) of patients were cured, compared with 32% (6 out of 19) of patients receiving best available antibiotic treatment.
Med bolniki, ki so bili zdravljeni z zdravilom Vabomere, jih je ozdravilo skupno 60 % (21 od 35), v primerjavi z 32 % (6 od 19) bolnikov, ki so prejemali najboljše razpoložljivo zdravljenje z antibiotikom.
Vabomere was compared with the doctor's choice of the best available antibiotic treatment.
Zdravilo Vabomere so primerjali z najboljšim razpoložljivim zdravljenjem z antibiotikom po izbiri zdravnika.
The most common side effects with Vabomere (which may affect up to 1 in 10 people) are headache, diarrhoea, inflammation of the vein around the infusion site and nausea (feeling sick).
Najpogostejši neželeni učinki zdravila Vabomere (ki lahko prizadenejo več kot 1 osebo od 10) so glavobol, driska, vnetje vene okoli mesta infundiranja in navzeja (slabost).
These enzymes break down beta-lactam antibiotics such as meropenem and stop them from working.
Ti encimi razgrajujejo betalaktamske antibiotike, kot je meropenem, in jim preprečijo delovanje.
Vabomere must not be used in patients who are hypersensitive (allergic) to any carbapenem antibiotic or in patients who have had a severe allergic reaction to the broader class of beta-lactam antibiotics (such as penicillins and cephalosporins).
Zdravilo Vabomere se ne sme uporabljati pri bolnikih, ki so preobčutljivi za (alergični na) kateri koli karbapenemski antibiotik ali pri bolnikih, ki so imeli hudo alergijsko reakcijo na širši razred betalaktamskih antibiotikov (kot so penicilini in cefalosporini).
Meropenem belongs to the carbapenem class of antibiotics, which belongs to the wider group of antibiotics known as beta-lactams.
Meropenem spada v skupino karbapenemskih antibiotikov, ki so uvrščeni v širšo skupino antibiotikov, znanih kot beta-laktami.
By blocking the action of these enzymes, vaborbactam allows meropenem to act against bacteria that would otherwise be resistant to it.
Vaborbaktam z zaviranjem delovanja teh encimov omogoča meropenemu, da deluje proti bakterijam, ki bi sicer bile nanj odporne.
The second study involved patients with complicated urinary tract infection (including kidney infection), complicated intra-abdominal infections, lung infections caught in hospital and bacteraemia.
V drugo študijo so bili vključeni bolniki z zapletenimi okužbami sečil (vključno z okužbo ledvic), zapletenimi intraabdominalnimi okužbami, okužbami pljuč, pridobljenimi v bolnišnici, in bakteriemijo.
The first study, involving patients with complicated urinary tract infection (including kidney infection), compared Vabomere with a combination of piperacillin (another beta-lactam antibiotic) and tazobactam (a beta-lactamase inhibitor).
V prvi študiji, v katero so bili vključeni bolniki z zapletenimi okužbami sečil (vključno z okužbo ledvic), so primerjali zdravilo Vabomere s kombinacijo piperacilina (drugega betalaktamskega antibiotika) in tazobaktama (zaviralca beta-laktamaze).
How is Vabomere used?
Kako se zdravilo Vabomere uporablja?
It is given every 8 hours and the duration of treatment depends on the type of infection and its severity.
Injicira se vsakih osem ur, trajanje zdravljenja pa je odvisno od vrste in resnosti okužbe Za več informacij glede uporabe zdravila Vabomere glejte navodilo za uporabo ali se posvetujte z zdravnikom ali farmacevtom.
No special concerns about side effects have been raised by the addition of vaborbactam to meropenem.
Zaradi neželenih učinkov, ki bi jih povzročilo dodajanje vaborbaktama meropenemu, ni izrazila nobenega posebnega pomisleka.
Vaborbactam allows meropenem to work in many such infections by blocking certain beta-lactamases.
Vaborbaktam omogoča meropenemu, da v številnih takih okužbah deluje z zaviranjem določenih beta-laktamaz.
Vabomere contains the active substances meropenem and vaborbactam.
Zdravilo Vabomere vsebuje učinkovini meropenem in vaborbaktam.
Vaborbactam is a beta-lactamase inhibitor, which means that it blocks the action of bacterial enzymes called beta-lactamases.
Vaborbaktam je zaviralec beta-laktamaze, kar pomeni, da v telesu zavira delovanje bakterijskih encimov, imenovanih beta-laktamaze.
• complicated (difficult-to-treat) infections of the urinary tract, including kidneys;
• zapletenih (težko ozdravljivih) okužb sečil, vključno z ledvicami;
For the full list of side effects of Vabomere, see the package leaflet.
Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Vabomere, glejte navodilo za uporabo.
Vabomere can only be obtained with a prescription.
Predpisovanje in izdaja zdravila je le na recept.
Vabomere is given by infusion (drip) into a vein over 3 hours.
Zdravilo Vabomere se daje kot triurna (kapalna) infuzija v veno.
• lung infections caught in hospital (hospital-acquired pneumonia), including ventilator-associated pneumonia (pneumonia caught from a ventilator, which is a machine that helps a patient to breathe).
• okužb pljuč, pridobljenih v bolnišnici (bolnišnična pljučnica), vključno z ventilatorsko pljučnico
How does Vabomere work?
Kako zdravilo Vabomere deluje?
A risk to newborns/infants cannot be excluded.
Tveganja za novorojenčke/otroke ni mogoče izključiti.
• Swallow the tablet whole with at least a half glass of water.
• Tableto pogoltnite celo, z najmanj pol kozarca vode.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 23 April 2014
Datum prve odobritve: 23. april 2014
• Try to take it at the same times each day.
• Poskušajte jemati tableto vsak dan ob istem času.
Multiple dose study: Data are restricted to one study.
Študija večkratnih odmerkov: Podatki se nanašajo na eno študijo.
• medicines that contain alcohol.
• zdravila, ki vsebujejo alkohol.
• The dose of Vokanamet is one tablet twice a day.
• Odmerek zdravila Vokanamet je ena tableta dvakrat na dan.
Consumption of alcohol and medicinal products containing alcohol should be avoided.
Uživanju alkohola in zdravil, ki vsebujejo alkohol, se je treba izogibati.
It is important that you follow your doctor's instructions carefully.
Zelo pomembno je, da se skrbno držite navodil svojega zdravnika.
ATC code: A10BD16.
Oznaka ATC: A10BD16.
• It is best to take your tablet with a meal.
• Tableto je najbolje vzeti ob obroku.
In both cases, treatment with Vokanamet may be restarted once the patient's condition has stabilised.
V obeh primerih se lahko zdravljenje z zdravilom Vokanamet ponovno uvede, ko je stanje bolnikov stabilizirano.
Tablets are to be swallowed whole.
Tablete je treba pogoltniti cele.
See section “Warning and precautions”.
Glejte poglavje “Opozorila in previdnostni ukrepi”.
As an underlying mechanism has not been established, risk factors, apart from general risk factors, for amputation are unknown.
Osnovnega mehanizma niso ugotovili, zato razen splošnih dejavnikov tveganja dejavniki tveganja za amputacije niso znani.
The red blood cells most likely represent a secondary compartment of distribution.
Eritrociti najverjetneje predstavljajo sekundarni predelek porazdelitve.
How much to take
Koliko zdravila je potrebno vzeti
16% of patients were Hispanic.
16% bolnikov je bilo latinskoameriškega izvora.
• difficulty in breathing
• težave z dihanjem
More information is given below in "Other medicines and Vokanamet".
Več podatkov lahko najdete spodaj pod naslovom "Druga zdravila in zdravilo Vokanamet".
After an oral dose, the non-absorbed fraction recovered in faeces was 20-30%.
Po peroralnem odmerjanju je neabsorbirani delež v blatu znašal 20-30%.
• if you are allergic to canagliflozin, metformin or any of the other ingredients of this medicine (listed in section 6)
• če ste alergični na kanagliflozin, metformin ali katero koli sestavino tega zdravila (navedeno v poglavju 6)
Do not use this medicine after the expiry date which is stated on the bottle and carton after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na plastenki in na škatli poleg oznake "EXP".
For the list of excipients, see section 6.1.
Za celoten seznam pomožnih snovi glejte poglavje 6.1.
Following an oral dose, the apparent terminal elimination half-life is approximately 6.5 hours.
Po peroralnem odmerku je navidezni končni razpolovni čas izločanja približno 6,5 ur.
If no adequate strength of Vokanamet is available, individual monocomponents should be used instead of the fixed dose combination.
Če ni na voljo ustrezna jakost zdravila Vokanamet, je treba namesto fiksne kombinacije uporabiti posamične monokomponente.
• if you have a severe infection
• če prebolevate hudo okužbo
Metformin is excreted into human breast milk in small amounts.
Metformin se izloča v materino mleko v majhnih količinah.
• if you are on medicines to lower your blood pressure (anti-hypertensives) or have ever had low blood pressure (hypotension).
• če jemljete zdravila za zniževanje krvnega tlaka (antihipertenzive) in ste imeli že kdaj znižan krvni tlak (hipotenzijo).
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking or continuing to take this medicine.
Nosečnost in dojenje Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo ali preden nadaljujete z jemanjem tega zdravila.
The safety and efficacy of Vokanamet in children under 18 years of age have not been established.
Varnost in učinkovitost zdravila Vokanamet pri otrocih, mlajših od 18 let, še nista bili dokazani.
• medicines which increase urine production (diuretics)
• zdravila, ki povečajo nastajanje urina (duiretiki)
If any of the above applies to you, talk to your doctor for further instructions.
Če kar koli od zgoraj navedenega velja za vas, se za neč navodil posvetujte z zdravnikom.
When this happens, sugar (glucose) builds up in the blood.
Če pride do tega, se koncentracija sladkorja (glukoze) v krvi zviša.
The effect of Vokanamet on fertility in humans has not been studied.
Vpliva zdravila Vokanamet na plodnost pri ljudeh niso preučevali.
This will lower your chance of having an upset stomach.
S tem boste zmanjšali možnost za draženje želodca.
Ketoacidosis is a condition in which substances called 'ketone bodies' accumulate in the blood and which can lead to diabetic pre-coma.
Ketoacidoza je stanje, pri katerem se snovi, imenovane 'ketonska telesa ' kopičijo v krvi, kar lahko povzroči diabetično predkomo.
• common: a metallic taste (taste disturbance)
• pogosti: kovinski okus (motnja okušanja)
A limited amount of data from the use of metformin in pregnant women does not indicate an increased risk of congenital malformations.
Maloštevilni podatki o uporabi metformina pri nosečnicah ne kažejo na povečano tveganje za prirojene anomalije.
211 patients from the clinical study in older patients participated in a body composition substudy using DXA body composition analysis.
211 bolnikov iz klinične študije s starejšimi bolniki je sodelovalo v podskupini, v kateri so bolnikom analizirali sestavo telesa z metodo DEXA.
These changes are not likely to be clinically relevant.
Navedene spremembe po vsej verjetnosti niso klinično pomembne.
This is because this medicine can affect the way some other medicines work.
To zdravilo namreč lahko vpliva na delovanje nekaterih drugih zdravil, pa tudi nekatera druga zdravila lahko vplivajo na delovanje tega zdravila.
Side effects when taking metformin alone that were not described for canagliflozin:
Neželeni učinki pri jemanju samo metformina, ki jih niso opisovali pri jemanju kanagliflozina:
• Your doctor will prescribe the strength that is right for you.
• Zdravnik vam bo predpisal ustrezno jakost zdravila.
• if you have lost a lot of water from your body (dehydration), e.g. due to long-lasting or severe diarrhoea, or if you have vomited several times in a row
• če ste iz telesa izgubili veliko vode (ste dehidrirani) na primer zaradi dolgotrajne ali hude driske ali če ste večkrat zaporedoma bruhali
• certain medicines for the treatment of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists)
• nekatera zdravila za zdravljenje visokega krvnega tlaka (zaviralci ACE in antagonisti receptorjev angiotenzina II)
Lactic acidosis is a medical emergency and must be treated in a hospital.
Laktacidoza je nujno zdravstveno stanje in jo je treba zdraviti v bolnišnici.
The maximum daily dose of metformin should preferably be divided into 2-3 daily doses.
Najbolje je, da se največji dnevni odmerek metformina je razdeli v 2 do 3 dnevne odmerke.
In addition, in such patients greater decreases in GFR were reported (see sections 4.2 and 4.8).
Poleg tega so pri teh bolnikih poročali tudi o večjem zmanjšanju GFR (glejte poglavji 4.2 in 4.8).
b Gastrointestinal symptoms such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite occur most frequently during initiation of therapy and resolve spontaneously in most cases.
b Gastrointestinalni simptomi, kot so navzea, bruhanje, diareja, bolečine v trebuhu in izguba apetita, se najpogosteje pojavljajo ob začetku zdravljenja in v večini primerov spontano izzvenijo.
The most effective method to remove lactate and metformin is haemodialysis.
Najbolj učinkovit način odstranjevanja laktata in metformina je hemodializa.
There was no notable change in heart rate.
Pri tem ni bilo opazne spremembe srčne frekvence.
The observed pharmacokinetic and pharmacodynamic responses were consistent with those found in adult subjects.
Farmakokinetični in farmakodinamični odgovori so bili skladni z odgovori, ki so jih opazili pri odraslih preiskovancih.
When starting or using such products in combination with Vokanamet, close monitoring of renal function is necessary.
Ob uvedbi ali uporabi teh zdravil v kombinaciji z zdravilom Vokanamet je potrebno skrbno spremljanje delovanja ledvic.
• Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis);
• Vse vrste akutne metabolične acidoze (kot sta laktacidoza, diabetična ketoacidoza).
However, as precautionary measures, consideration should be given to carefully monitoring patients with a higher risk for amputation events and counselling patients about the importance of routine preventative foot care and maintaining adequate hydration.
Upoštevati je treba varnostne ukrepe kot so skrbno spremljanje bolnikov z večjim tveganjem za amputacije ter podučitev bolnikov o pomembnosti rutinske nege stopal in vzdrževanju zadostne hidracije.
Some studies indicate that taking canagliflozin may have contributed to the risk of lower limb amputation (mainly toe amputations).
Nekatere študije kažejo, da lahko jemanje kanagliflozina prispeva k tveganju za amputacije spodnjih okončin (večinoma prstov na nogah).
• The strength of Vokanamet that you will take varies depending on your condition and the amount of canagliflozin and metformin needed to control your blood sugar.
• Jakost zdravila Vokanamet, ki ga boste jemali je odvisna od vaše bolezni in od tega, koliko kanagliflozina in metformina potrebujete za uravnavanje koncentracije sladkorja v krvi.
• if you have recently had a heart attack or have severe blood circulation problems, such as ‘shock' or breathing difficulties
• če ste pred nedavnim doživeli srčni infarkt ali če imate resne težave s krvnim obtokom, kot sta šok ali oteženo dihanje
The doctor may decide to temporarily or permanently stop the treatment with Vokanamet.
Zdravnik vam lahko začasno ali trajno ukine zdravljenje z zdravilom Vokanamet.
Other side effects when taking canagliflozin alone: Very common (may affect more than 1 in 10 people)
Drugi neželeni učinki pri jemanju samo kanagliflozina: Zelo pogosti (lahko se pojavijo pri več kot 1 od 10 bolnikov)
After an oral dose of metformin hydrochloride tablet, Cmax is reached in approximately 2.5 hours (Tmax).
Po peroralni aplikaciji tablete z metforminijevim kloridom je Cmax dosežen po približno 2,5 ure (Tmax).
• Severe renal failure (GFR < 30 mL/min) (see sections 4.2 and 4.4);
• Huda ledvična odpoved (GFR < 30 ml/min ) (glejte poglavji 4.2 in 4.4).
Most infections were mild to moderate with no increase in the occurrence of serious adverse reactions.
Večina okužb je bila blagih do zmernih, pogostnost resnih neželenih učinkov pri tem ni bila povečana.
Vokanamet should not be used during pregnancy.
Zdravila Vokanamet se ne sme uporabljati med nosečnostjo.
Vokanamet should be taken orally twice daily with meals to reduce the gastrointestinal undesirable effects associated with metformin.
Zdravilo Vokanamet je treba jemati peroralno dvakrat na dan, z obrokom, da se zmanjša z metforminom povezane gastrointestinalne neželene učinke.
• Hepatic impairment, acute alcohol intoxication, alcoholism (see sections 4.2 and 4.5).
• Okvara jeter, akutna zastrupitev z alkoholom, alkoholizem (glejte poglavji 4.2 in 4.5).
You may already be taking one or more of these to treat your type 2 diabetes.
Morda za zdravljenje sladkorne bolezni tipa 2 že jemljete eno ali več navedenih zdravil.
The patient should be informed and more frequent blood glucose monitoring performed, especially at the beginning of treatment with such medicinal products.
Bolnik mora biti o tem poučen, koncentracijo glukoze v krvi pa je treba meriti pogosteje, še posebej na začetku zdravljenja s temi zdravili.
You may need more frequent blood glucose and kidney function tests, or your doctor may need to adjust the dosage of Vokanamet.
Morda boste morali pogosteje opravljati preiskave glukoze v krvi in delovanje ledvic, zdravnik pa bo morda moral prilagoditi odmerek zdravila Vokanamet.
The blood peak is lower than the plasma peak and appears at approximately the same time.
Največja koncentracija v krvi je manjša od največje koncentracije v plazmi, nastopi pa ob približno istem času.
• It is important to check your feet regularly and adhere to any other advice regarding foot care and adequate hydration given by your health care professional.
• Pomembno je, da si redno pregledujete stopala in upoštevate nasvete zdravstvenih delavcev o negi stopal in vzdrževanju zadostne količine telesnih tekočin (hidracije).
If you stop taking Vokanamet
Če ste prenehali jemati zdravilo Vokanamet