natgillin/translations-raw huggingface dataset:
Somnambulism and related reactions such as sleep talking and sleep related eating disorder
somnambuliz em in podobne reakcije, npr. govorjenje med spanjem ali s spanjem povezana motnja hranjenja
In the continuation phase in two of these studies, it was demonstrated that long-term treatment, of patients who responded on Seroquel IR 300 or 600 mg, was efficacious compared to placebo treatment with respect to depressive symptoms, but not with regard to manic symptoms.
V nadaljevalni fazi dveh od teh študij je bilo dokazano, da je dolgotrajno zdravljenje bolnikov, ki so se odzvali na zdravilo Seroquel 300 mg ali 600 mg, učinkovito v primerjavi s placebom, kar zadeva simptome depresije, ne pa, kar zadeva simptome manije.
Less than 1% of patients had an increase to a prolactin level >100 ug/L.
Pri manj kot 1 % bolnikov se je koncentracija prolaktina zvišala na > 100 ug/l.
• Seroquel XR can be affected by food and you should therefore take your tablets at least one hour before a meal or prior to bedtime.
• Hrana lahko vpliva na zdravilo Seroquel SR, zato morate vzeti tableto s podaljšanim sproščanjem vsaj eno uro pred obrokom ali pred spanjem.
Given its primary central nervous system effects, quetiapine may interfere with activities requiring mental alertness.
Zaradi svojih primarnih učinkov na osrednji živčni sistem lahko kvetiapin vpliva na dejavnosti, ki zahtevajo pozornost.
The following studies were conducted with Seroquel XR as monotherapy treatment, however Seroquel XR is only indicated for use as add-on therapy:
Naslednje študije so bile izvedene z zdravilom Seroquel SR kot monoterapijo, vendar je zdravilo Seroquel SR indicirano le za uporabo kot dodatno zdravilo:
Weight should be monitored regularly.
Redno je treba kontrolirati telesno maso.
Patients should be observed for signs and symptoms of infection and neutrophil counts followed (until they exceed 1.5 X 109/L) (see section 5.1).
Bolnike je potrebno spremljati glede znakov in simptomov okužbe ter jim kontrolirati število nevtrofilcev (dokler ne preseže 1,5 x 109/l) (glejte poglavje 5.1).
QT Prolongation:
Podaljšanje intervala QT:
Severe Neutropenia and agranulocytosis:
Huda nevtropenija in agranulocitoza:
This could increase the occurrence of accidental injury (fall), especially in the elderly population.
To lahko poveča pojavljanje naključnih poškodb (padci), zlasti pri starejših bolnikih.
This effect occurred in the presence of overt maternal effects such as reduced body weight gain.
Ta učinek se je pojavil v prisotnosti manifestnih učinkov pri samicah-materah, npr. zmanjšanega pridobivanja telesne mase.
Whilst the prevention of absorption in overdose has not been investigated, gastric lavage can be indicated in severe poisonings and if possible to perform within one hour of ingestion.
Čeprav možnosti preprečevanja absorpcije prevelikih odmerkov niso preučevali, lahko razmislimo tudi o možnosti uporabe praznjenja želodca pri hudih zastupitvah in ga izvesti, če je mogoče, v eni uri po zaužitju.
This increase in clearance reduced systemic quetiapine exposure (as measured by AUC) to an average of 13% of the exposure during administration of quetiapine alone; although a greater effect was seen in some patients.
To povečanje očistka je zmanjšalo sistemsko izpostavljenost kvetiapinu (izmerjeno z AUC) v povprečju na 13-% izpostavljenost glede na uporabo samega kvetiapina; pri nekaterih bolnikih so opazili še večji učinek.
Quetiapine and norquetiapine have no appreciable affinity at benzodiazepine receptors but high affinity at histaminergic and adrenergic alpha1 receptors, moderate affinity at adrenergic alpha2 receptors and moderate to high affinity at several muscarinic receptors.
Kvetiapin in norkvetiapin nimata upoštevanja vredne afinitete za benzodiazepinske receptorje, imata pa veliko afiniteto za histaminergične receptorje in adrenergične receptorje alfa 1, zmerno afiniteto za adrenergične receptorje alfa 2 ter zmerno do veliko afiniteto za več muskarinskih receptorjev.
An increase in LDL cholesterol of ≥30 mg/dL (≥0.769 mmol/L) has been very commonly observed.
Povečanje LDL holesterola ≥ 30 mg/dl (≥ 0,769 mmol/l) je bilo opisano v zelo pogostih primerih.
When Seroquel XR is being taken to treat major depressive episodes in major depressive disorder, it will be taken in addition to another drug being used to treat this illness.
Če je zdravilo Seroquel SR uporabljeno za zdravljenje velikih depresivnih epizod pri veliki depresivni motnji, ga je treba jemati kot dodatek k nekemu drugemu zdravilu, namenjenemu zdravljenju te bolezni.
• You will take your tablets once a day.
• Tablete s podaljšanim sproščanjem boste jemali enkrat na dan.
Furthermore, the long-term safety implications of treatment with quetiapine on growth and maturation have not been studied beyond 26 weeks.
Poleg tega, dolgoročne varnostne posledice zdravljenja s kvetiapinom za rast in dozorevanje niso raziskane, če zdravljenje traja več kot 26 tednov.
Quetiapine should be used with caution in patients with known cardiovascular disease, cerebrovascular disease, or other conditions predisposing to hypotension.
Kvetiapin je treba uporabljati previdno pri bolnikih z znanimi srčno-žilnimi boleznimi, možganskožilnimi boleznimi in drugimi stanji, ki povzročajo nagnjenost k hipotenziji.
The incidences of ADRs associated with quetiapine therapy, are tabulated below (Table 1) according to the format recommended by the Council for International Organizations of Medical Sciences (CIOMS III Working Group; 1995).
Pogostnost pojavljanja neželenih učinkov, povezanih z uporabo kvetiapina, je navedena v spodnji preglednici (Preglednica 1) v skladu z obliko, ki jo priporoča Council for International Organizations of Medical Sciences (Delovna skupina CIOMS III 1995).
Effects related to elevated prolactin levels were seen in rats, although these are not directly relevant to humans (see section 5.3 preclinical data).
Pri podganah so ugotovili učinke, povezane z zvišanjem prolaktina, vendar ti niso neposredno relevantni za človeka (glejte poglavje 5.3, Predklinični podatki).
dizziness, and irritability.
bruhanje, omotico in razdražljivost.
There have been reports of false positive results in enzyme immunoassays for methadone and tricyclic antidepressants in patients who have taken quetiapine.
Poročajo o lažno pozitivnih rezultatih encimskih preiskav (EIA) za določanje metadona in tricikličnih antidepresivov pri bolnikih, ki so prejemali kvetiapin.
The usual effective dose is in the range of 400 to 800 mg/day.
Običajno učinkovit odmerek je med 400 do 800 mg na dan.
The use of quetiapine has been associated with the development of akathisia, characterised by a subjectively unpleasant or distressing restlessness and need to move often accompanied by an inability to sit or stand still.
Uporabo kvetiapina je spremljal pojav akatizije, za katero sta značilna subjektivno neprijeten ali zoprn nemir ter potreba po gibanju, pogosto hkrati z bolnikovo nezmožnostjo, da bi stal ali sedel pri miru.
Agranulocytosis26
agranulocitoz a26
Do not use physostigmine in case of dysrhythmias, any degree of heart block or QRS-widening.
Fizostigmin se ne sme uporabljati v primeru disaritmij, katerih koli stopenj srčnega bloka ali razširitve
In a third short-term placebo-controlled monotherapy trial with Seroquel XR in children and adolescent patients (10-17 years of age) with bipolar depression, efficacy was not demonstrated.
Tretje kratkotrajno, s placebom kontrolirano preskušanje monoterapije z zdravilom Seroquel SR pri otrocih in mladostnikih (starih od 10 do 17 let) z bipolarno depresijo ni dokazalo učinkovitosti.
When Seroquel XR is compared to Seroquel immediate release, the norquetiapine metabolite AUC is 18% lower.
Ko primerjamo zdravilo Seroquel SR z zdravilom Seroquel je AUC za norkvetiapinijev metabolit 18 % nižji.
About 45% of the patient population had an additional diagnosis of ADHD.
Približno 45 % te populacije bolnikov je imelo dodatno diagnozo ADHD (motnje s pomanjkanjem pozornosti in hiperaktivnostjo).
In pre-clinical tests predictive of EPS, quetiapine is unlike typical antipsychotics and has an atypical profile.
V predkliničnih testih, ki napovedujejo EPU (ekstrapiramidne neželene učinke), se kvetiapin razlikuje od tipičnih antipsihotikov in ima atipičen profil.
• Feeling sleepy (this may go away with time, as you keep taking Seroquel) (may lead to falls).
• občutek zaspanosti (ta lahko sčasoma mine, ko nadaljujete jemanje zdravila Seroquel ) (lahko povzroči padce),
Both in mania and schizophrenia higher doses resulted in numerically lower response rates.
Tako pri maniji kot pri shizofreniji so večji odmerki dosegli številsko manjše deleže odziva.
Concomitant use of quetiapine with a strong hepatic enzyme inducer such as carbamazepine or phenytoin substantially decreases quetiapine plasma concentrations, which could affect the efficacy of quetiapine therapy.
Sočasna uporaba kvetiapina in močnih induktorjev jetrnih encimov, kot sta karbamazepin ali fenitoin, bistveno zmanjša plazemske koncentracije kvetiapina, kar lahko vpliva na učinkovitost zdravljenja s kvetiapinom.
The rate of dose titration of Seroquel XR may need to be slower, and the daily therapeutic dose lower, than that used in younger patients.
Potrebno utegne biti počasnejše titriranje zdravila Seroquel SR, dnevni terapevtski odmerek pa je lahko nižji kot pri mlajših bolnikih.
• Severe rash, blisters, or red patches on the skin.
• hud izpuščaj, mehurji ali rdeče lise po koži,
Quetiapine and norquetiapine exhibit affinity for brain serotonin (5HT2) and dopamine D1- and D2- receptors.
Kvetiapin in norkvetiapin imata afiniteto za možganske receptorje za serotonin (5HT2) in dopamin (D1 in D2).
The primary outcome variable in the placebo-controlled trial was change from baseline to final assessment in the PANSS total score.
Primarna spremenljivka izida v preskušanju, kontroliranem s placebom, je bila sprememba celotnega seštevka po PANSS od izhodišča do končne ocene.
A placebo-controlled trial evaluating fixed doses of quetiapine across the range of 75 to 750 mg/day showed no evidence of an increase in EPS or the use of concomitant anticholinergics.
V nadzorovanem preskušanju s placebom z ustaljenimi odmerki kvetiapina v območju od 75 do 750 mg/dan niso dokazali povečanja EPS ali sočasne uporabe antiholinergikov.
You should not take Seroquel during pregnancy unless this has been discussed with your doctor.
Ne jemljite zdravila Seroquel med nosečnostjo, razen če se o tem niste pogovorili s svojim zdravnikom.
Seroquel XR achieves peak quetiapine and norquetiapine plasma concentrations at approximately 6 hours after administration (Tmax).
Zdravilo Seroquel SR doseže vrh koncentracije kvetiapina in norkvetiapina v plazmi približno 6 ur po uporabi (tmax).
Clinical manifestations include hyperthermia, altered mental status, muscular rigidity, autonomic instability, and increased creatine phosphokinase.
Klinični znaki sindroma so hipertermija, spremembe psihičnega statusa, mišična togost, avtonomna nestabilnost in povečane vrednosti kreatin-fosfokinaze.
(31) See Section 4.6.
(31) Glejte poglavje 4.6.
Increased appetite, blood glucose increased to hyperglycaemic levels 6, 30
povečanje telesne mase povečan apetit, zvišanje glukoze v krvi do hiperglikemične ravni 6, 30
In addition, these conditions may be co-morbid with major depressive episodes.
Ta stanja so lahko dodatno prisotna poleg velikih depresivnih epizod.
Bipolar Disorder
Bipolarna motnja
• Feeling weak.
• občutek šibkosti,
This may make you feel dizzy or faint (may lead to falls).
Posledici sta lahko omotica ali omedlevica (lahko povzroči padce).
• Unpleasant sensations in the legs (also called restless legs syndrome).
• neprijeten občutek v nogah (tako imenovan sindrom nemirnih nog),
9/L.
celic/l.
If signs and symptoms of tardive dyskinesia appear, dose reduction or discontinuation of quetiapine should be considered.
Če se pojavijo znaki in simptomi zapoznele diskinezije, je treba razmisliti o zmanjšanju odmerka ali prekinitvi uporabe kvetiapina.
For about 2/3 of all cases, cessation of quetiapine treatment was associated with a reversal of the effects on total and free T4, irrespective of the duration of treatment.
V približno 2/3 vseh primerov je učinek na celotni in prosti T4 po prenehanju zdravljenja s kvetiapinom izginil, ne glede na trajanje zdravljenja.
Possible risk factors for neutropenia include pre-existing low white blood cell count (WBC) and history of drug induced neutropenia.
Med možnimi dejavniki tveganja za nevtropenijo sta že prisotno manjše število belih krvnih celic in predhodna, z zdravili povzročena nevtropenija.
Effect on Urine Drug Screens
Vpliv na urinske teste
The mean dose of Seroquel XR during the randomised phase was 177 mg/day.
Povprečni odmerek zdravila Seroquel SR med randomizirano fazo je bil 177 mg/dan.
Based on shifts above clinically significant thresholds (adapted from the National Institutes of Health criteria) or increases >20 mmHg for systolic or >10 mmHg for diastolic blood pressure at any time in two acute (3-6 weeks) placebo-controlled trials in children and adolescents.
Na podlagi sprememb nad klinično pomembnimi pragi (prirejeno po merilih National Institutes of Health) ali zvišanja sistoličnega tlaka > 20 mmHg ali diastoličnega tlaka > 10 mmHg kadarkoli v dveh akutnih (3- do 6-tedenskih) s placebom kontroliranih preskušanjih pri otrocih in mladostnikih.
The same side effects that may occur in adults may also occur in children and adolescents.
Enaki neželeni učinki, ki se lahko pojavijo pri odraslih, se lahko pojavijo tudi pri otrocih in mladostnikih.
During an extended post-treatment follow-up phase of the bipolar depression trial, there were two additional suicide related events in two patients; one of these patients was on quetiapine at the time of the event.
V fazi podaljšanega spremljanja po zdravljenju v preskušanju pri bipolarni depresiji so zabeležili dva dodatna s samomorom povezana dogodka pri dveh bolnikih; eden od obeh bolnikov je v času dogodka prejemal kvetiapin.
• The active substance is quetiapine.
• Zdravilna učinkovina je kvetiapin.
Anaphylactic reaction5
anafilaktična reakcija5
What Seroquel is and what it is used for
Kaj je zdravilo Seroquel in za kaj ga uporabljamo
Tablet coating: hypromellose, macrogol, titanium dioxide (E171).
Obloga tablete: hipromeloza, makrogol, titanov dioksid (E171).
As with other antipsychotics, caution is recommended when treating patients with a history of seizures (see Section 4.8).
Tako kot pri drugih antipsihotičnih zdravilih je priporočljiva previdnost pri zdravljenju bolnikov z anamnezo konvulzij (glejte poglavje 4.8).
• Thioridazine or Lithium (other anti-psychotic medicines).
• tioridazin ali litij (drugi antipsihotični zdravili),
For preventing recurrence in bipolar disorder
Za preprečevanje ponavljanja epizod bipolarne motnje
NAME OF THE MARKETING AUTHORISATION HOLDER AstraZeneca
IME IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM AstraZeneca
In cases of severe signs, the possibility of multiple drug involvement should be considered, and intensive care procedures are recommended, including establishing and maintaining a patent airway, ensuring adequate oxygenation and ventilation, and monitoring and support of the cardiovascular system.
Priporočljivi so postopki intenzivne terapije, vključno z vzpostavitvijo in vzdrževanjem prehodnih dihalnih poti, zagotovitvijo ustrezne oksigenacije in ventilacije ter nadziranjem in podporo srčno-žilnega sistema.
Your doctor may continue to prescribe Seroquel even when you are feeling better.
Zdravnik vam lahko še naprej predpiše zdravilo Seroquel, tudi če se počutite bolje.
Hyperglycaemia and/ or development or exacerbation of diabetes occasionally associated with ketoacidosis or coma has been reported rarely, including some fatal cases (see section 4.8).
Redko so poročali o hiperglikemiji in/ali pojavu ali poslabšanju sladkorne bolezni, občasno s ketoacidozo ali komo, vključno z nekaj smrtnimi primeri (glejte poglavje 4.8).
From animal studies it appears that quetiapine can induce cytochrome P450 enzymes.
Študije na živalih kažejo, da lahko kvetiapin inducira encime citokroma P450.
In an interaction study in healthy volunteers, concomitant administration of quetiapine (dosage of 25 mg) with ketoconazole, a CYP3A4 inhibitor, caused a 5-to 8-fold increase in the AUC of quetiapine.
V študijah interakcij na zdravih prostovoljcih je sočasna uporaba kvetiapina (odmerek 25 mg) s ketokonazolom, zaviralcem CYP3A4, povzročila 5- do 8-kratni porast AUC kvetiapina.
• A condition (called “metabolic syndrome”) where you may have a combination of 3 or more of the following: an increase in fat around your abdomen, a decrease in “good cholesterol” (HDL-C), an increase in a type of fat in your blood called triglycerides, high blood pressure and an increase in your blood sugar.
• stanje, imenovano metabolni sindrom, pri katerem imate lahko kombinacijo 3 ali več sledečih simptomov: povečanje maščobnih oblog v predelu trebuha, znižanje koncentracije “dobrega“ holesterola (HDL), zvišanje koncentracije vrste maščob v krvi imenovane trigliceridi, visok krvni tlak in zvišan sladkor v krvi,
Patients treated with any antipsychotic agent including quetiapine, should be observed for signs and symptoms of hyperglycaemia, (such as polydipsia, polyuria, polyphagia and weakness) and patients with diabetes mellitus or with risk factors for diabetes mellitus should be monitored regularly for worsening of glucose control.
Bolnike, ki dobivajo katerikoli antipsihotik, vključno s kvetiapinom, je treba spremljati glede znakov in simptomov hiperglikemije (npr. polidipsije, poliurije, polifagije in šibkosti), bolnike, ki imajo sladkorno bolezen ali dejavnike tveganja zanjo, pa redno kontrolirati, da bi odkrili poslabšanje urejenosti glukoze.
Tachycardia Palpitations23
Srčne bolezni tahikardija palpitacije23
Different dosing schedules exist for each indication.
4.2 Odmerjanje in način uporabe Za vsako indikacijo obstajajo različne sheme odmerjanja.
(5) Calculation of Frequency for these ADR's have only been taken from postmarketing data with the immediate release formulation of quetiapine.
(5) Izračuni pogostnosti teh neželenih učinkov zajemajo le podatke pridobljene po prihodu kvetiapina (v obliki s takojšnjim sproščanjem) na trg.
It is important that any change in the inducer is gradual, and if required, replaced with a non-inducer (e.g. sodium valproate).
Pomembno je, da je vsaka sprememba v zdravljenju z induktorjem postopna, in če je treba, lahko induktor nadomestimo z zdravilom, ki ne inducira jetrnih encimov (npr. natrijevim valproatom).
It is recommended that Seroquel XR is taken once daily without food.
Zato se priporoča jemanje zdravila Seroquel SR brez hrane enkrat na dan.
Patients experiencing somnolence of severe intensity may require more frequent contact for a minimum of 2 weeks from onset of somnolence, or until symptoms improve and treatment discontinuation may need to be considered.
Bolniki, ki se jim pojavi zelo izrazita zaspanost, lahko potrebujejo pogostejše preglede vsaj 2 tedna od pojava zaspanosti, ali dokler se simptomi ne izboljšajo; v poštev lahko pride tudi prekinitev zdravljenja.
Given the observed risk for worsening of their metabolic profile, including changes in weight, blood glucose (see hyperglycemia) and lipids, which was seen in clinical studies, patients' metabolic parameters should be assessed at the time of treatment initiation and changes in these parameters should be regularly controlled for during the course of treatment.
Glede na ugotovljeno tveganje za poslabšanje presnovnega stanja, vključno s spremembami telesne mase, glukoze v krvi (glejte Hiperglikemija) in maščob v krvi, ki so ga opažali v kliničnih študijah, je treba bolnikove presnovne parametre oceniti ob uvedbi zdravljenja, njihove spremembe pa redno kontrolirati ves čas zdravljenja.
In a meta-analysis of atypical antipsychotics, it has been reported that elderly patients with dementiarelated psychosis are at an increased risk of death compared to placebo.
V meta-analizi atipičnih antipsihotičnih zdravil so poročali, da je pri starejših bolnikih, ki imajo s psihozo povezano demenco, povečano tveganje za smrt v primerjavi s placebom.
Your doctor may continue to prescribe Seroquel XR even when you feel better.
Zdravnik vam lahko še naprej predpiše zdravilo Seroquel SR, tudi če se počutite bolje.
Inappropriate antidiuretic hormone secretion
neustrezno izločanje antidiuretične ga hormona
In individual patients, in the event of tolerance concerns, clinical trials have indicated that dose reduction to a minimum of 200 mg could be considered.
Klinične raziskave so pokazale, da lahko pri posameznih bolnikih, če nas skrbi toleranca, razmislimo o znižanju odmerka na minimalno 200 mg.
• Uncontrollable movements, mainly of your face or tongue.
• nekontrolirani gibi, večinoma obraza ali jezika,
Pancreatitis has been reported in clinical trials and during post marketing experience.
O pankreatitisu so poročali v kliničnih raziskavah in v obdobju po prihodu zdravila na trg.
Interactions: See also section 4.5.
Medsebojno delovanje: Glejte tudi poglavje 4.5.
Caution should be exercised when quetiapine is used concomitantly with medicinal products known to cause electrolyte imbalance or to increase QT interval.
Potrebna je previdnost, če se kvetiapin uporablja sočasno z zdravili, za katere je znano, da povzročijo elektrolitsko neravnovesje ali podaljšajo QT interval.
See section 5.1
Glejte poglavje 5.1.
Seroquel XR with food, drink and alcohol
Zdravilo Seroquel SR skupaj s hrano, pijačo in alkoholom
In open label trials, in patients with schizophrenia, quetiapine was effective in maintaining the clinical improvement during continuation therapy in patients who showed an initial treatment response, suggesting some long-term efficacy.
odprtih preskušanjih pri bolnikih s shizofrenijo je kvetiapin pri bolnikih, ki so se uvodoma odzvali na zdravljenje, učinkovito ohranil klinično izboljšanje med nadaljevanjem zdravljenja, kar nakazuje določeno dolgoročno učinkovitost.
For the treatment of schizophrenia
Za zdravljenje shizofrenije
• You are an elderly person with dementia (loss of brain function).
povzročila druga zdravila, • ste starejša oseba z demenco (poslabšanim delovanjem možganov).
Paediatric Population:
Pediatrična populacija:
• Medicines that have an impact on the way your heart beats, for example, drugs that can cause an imbalance in electrolytes (low levels of potassium or magnesium) such as diuretics (water pills) or certain antibiotics (drugs to treat infections).
• zdravila, ki vplivajo na vaše bitje srca, npr. zdravila, ki lahko povzročijo neravnovesje elektrolitov (nizko koncentracijo kalija ali magnezija); med takšnimi so diuretiki (tablete za odvajanje vode) in nekateri antibiotiki (zdravila za zdravljenje okužb),
Quetiapine demonstrates selectivity for the limbic system by producing depolarisation blockade of the mesolimbic but not the nigrostriatal dopamine-containing neurones following chronic administration.
Kvetiapin je selektiven za limbični sistem; to se kaže po kronični uporabi z depolarizacijsko blokado mezolimbičnih, ne pa nigrostriatnih nevronov, ki vsebujejo dopamin.
Pharmacotherapeutic group: Antipsychotics; Diazepines, oxazepines and thiazepines ATC code: N05A H04
Farmakoterapevtska skupina: antipsihotiki; diazepini, oksazepini in tiazepini Oznaka ATC: N05A H04
Frequency based on adverse event reports of bradycardia and related events in all clinical trials with quetiapine.
Pogostnost temelji na zabeleženih neželenih učinkih bradikardije in povezanih dogodkov v vseh kliničnih preskušanjih s kvetiapinom.
240 tablets
240 tablet
Quetiapine and the active human plasma metabolite, norquetiapine interact with a broad range of neurotransmitter receptors.
Kvetiapin in norkvetiapin, njegov aktivni presnovek v človeški plazmi, delujeta na širok spekter nevrotransmiterskih receptorjev.
(23) These reports often occurred in the setting of tachycardia, dizziness, orthostatic hypotension, and/or underlying cardiac/respiratory disease.
(23) To je bilo pogosto opisano v okoliščinah s tahikardijo, omotico, ortostatsko hipotenzijo in/ali osnovno boleznijo srca oz. dihal.
Distribution: Quetiapine is approximately 83% bound to plasma proteins.
Porazdelitev: Približno 83 % kvetiapina se veže na beljakovine v plazmi.