natgillin/translations-raw huggingface dataset:
• Dizziness or a severe sense of feeling sleepy.
• omotica ali občutek hude zaspanosti.
Formal interaction studies with commonly used cardiovascular medicinal products have not been performed.
Formalne študije medsebojnega delovanja s pogosto uporabljanimi srčno-žilnimi zdravili niso bile izvedene.
Your doctor may suggest you reduce the dose gradually before stopping treatment.
Zdravnik vam bo morda svetoval, da pred opustitvijo zdravila odmerek zmanjšujete postopoma.
An increased risk cannot be excluded for other antipsychotics or other patient populations.
Večjega tveganja ni mogoče izključiti za druga antipsihotična zdravila ali druge populacije bolnikov.
• You have had a stroke, especially if you are elderly
• ste imeli možgansko kap, zlasti če ste starejši,
The available evidence from placebo-controlled clinical trials is presented in sections 4.4, 4.8, 5.1 and 5.2.
Ugotovitve s placebom kontroliranih kliničnih preskušanj so predstavljene v poglavjih 4.4, 4.8, 5.1 in 5.2.
Your doctor may ask you to have blood tests from time to time.
Zdravnik vas bo zato morda občasno napotil na preiskavo krvi.
Lipid changes should be managed as clinically appropriate.
Spremembe lipidov naj bodo zdravljene, kot je klinično primerno.
These conditions can be caused by this type of medicine.
Te znake lahko povzroči ta skupina zdravil.
Efficacy and safety has not been evaluated in patients over 65 years with depressive episodes in the framework of bipolar disorder.
Učinkovitost in varnost nista ocenjeni pri bolnikih, starejših od 65 let, z depresivnimi epizodami v okviru bipolarne motnje.
Approximately 73% of the radioactivity is excreted in the urine and 21% in the faeces.
Približno 73 % radioaktivnosti se izloči v urinu in 21 % v blatu.
For these patients, the mean maximum decrease in hemoglobin at any time was -1.50 g/dL.
Pri teh bolnikih, je bilo povprečno največje znižanje hemoglobina kadarkoli -1,50 g/dl.
• Some medicines for HIV.
• nekatera zdravila za zdravljenje HIV,
• Feeling more hungry
• občutek večje lakote,
Some side effects are only seen when a blood test is taken.
Nekateri neželeni učinki se lahko odkrijejo le s preiskavo krvi.
This Summary of Product Characteristics, labelling and package leaflet is the outcome of the referral procedure to which this Commission decision relates.
Ta Povzetek glavnih značilnosti zdravila, Ovojnina in Navodilo za uporabo so rezultat napotitvenega postopka, s katerim je povezana odločitev Komisije.
The recommended daily dose is 300 mg.
Priporočeni dnevni odmerek je 300 mg.
Therefore, patients should be advised to exercise caution until they are familiar with the potential effects of the medication.
Zato je treba bolnikom naročiti, naj bodo previdni, dokler ne spoznajo možnih učinkov zdravila.
Contact your doctor or nearest hospital straight away.
Takoj pojdite do svojega zdravnika ali v najbližjo bolnišnico.
• Increased appetite
• povečan apetit,
In patients who develop these symptoms, increasing the dose may be detrimental.
Bolnikom, ki se jim pojavijo ti simptomi, lahko povečanje odmerka škoduje.
There is no specific antidote to quetiapine.
Specifičnega antidota za kvetiapin ni.
• Schizophrenia: where you may hear or feel things that are not there, believe things that are not true or feel unusually suspicious, anxious, confused, guilty, tense or depressed.
• shizofrenije: ko lahko slišite ali zaznavate stvari, ki jih ni, verjamete v stvari, ki niso resnične ali se počutite nenavadno sumničave, zaskrbljene, zmedene, krive, napete ali depresivne.
You may find it helpful to tell a relative or close friend that you are depressed, and ask them to read this leaflet.
Morda bi bilo koristno, če za težave z depresijo poveste sorodniku ali dobremu prijatelju, in ga prosite, da prebere to navodilo.
The maintenance dose (daily dose) will depend on your illness and needs but will usually be between 150 mg and 800 mg.
Vzdrževalni odmerek (dnevni odmerek) bo odvisen od vaše bolezni in potreb, a praviloma je odmerek med 150 mg in 800 mg.
All prolonged-release tablets are capsule shaped and marked with XR and the strength.
Vse tablete s podaljšanim sproščanjem so kapsulaste oblike in označene z oznako »XR« in jakostjo.
There are no data from long-term studies to demonstrate Seroquel's effectiveness in preventing subsequent manic or depressive episodes.
Ni podatkov iz dolgotrajnih študij, ki bi pokazali učinkovitost zdravila Seroquel pri preprečevanju poznejših maničnih ali depresivnih epizod.
Individual patients may benefit from a 600 mg dose.
Posameznim bolnikom lahko koristi odmerek 600 mg.
• You can take your tablets with or without food.
• Tablete lahko jemljete s hrano ali brez.
In laboratory animals at a clinically relevant exposure level the following deviations were seen, which as yet have not been confirmed in long-term clinical research:
Pri laboratorijskih živalih so ob klinično pomembni ravni izpostavljenosti opažali naslednje odklone, ki pa v dolgoročnih kliničnih raziskavah doslej še niso bili potrjeni:
If you notice any of these symptoms seek medical advice immediately.
Če opazite katerega od teh simptomov nemudoma poiščite zdravniško pomoč.
As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs.
Ker se prvih nekaj tednov zdravljenja ali dlje zdravstveno stanje morda še ne bo izboljšalo, je potrebno bolnike skrbno nadzirati, vse dokler ne pride do izboljšanja.
Do not drive or use any tools or machines until you know how the tablets affect you.
Ne vozite in ne upravljajte strojev, dokler ne veste, kako te tablete vplivajo na vas.
An increase in LDL cholesterol of ≥30 mg/dL
Povečanje LDL holesterola ≥ 30 mg/dl
Mechanism of action:
Mehanizem delovanja:
Physostigmine may be used if there are no ECG aberrations.
Fizostigmin se lahko uporablja le, če ni nobenih motenj EKG.
Most cases of severe neutropenia have occurred within a couple of months of starting therapy with quetiapine.
Večina primerov hude nevtropenije se je pojavila v nekaj mesecih po začetku zdravljenja s kvetiapinom.
CARTON AND LABEL FOR BOTTLE
ŠKATLA IN NALEPKA ZA PLASTENKO
However, based on all available data, a definite conclusion cannot be drawn.
Kljub temu dokončnega sklepa, na podlagi vseh podatkov ki so na voljo, ni mogoče narediti.
Therefore, patients should be advised not to drive or operate machinery, until individual susceptibility to this is known.
Zato je potrebno bolnikom svetovati, da ne vozijo ali upravljajo s stroji, dokler ni znana njihova individualna dovzetnost za ta učinek.
Mean change among patients who had this increase was 41.7 mg/dL (≥1.07 mmol/L).
Povprečna sprememba pri bolnikih, ki imajo to povečanje je bila 41,7 mg/dl (≥ 1,07 mmol/l).
(8) Based on >7% increase in body weight from baseline.
(8) Na podlagi >7 % povečanja telesne mase v primerjavi z izhodiščem.
Dose adjustments may be necessary in these patients (see section 4.2).
Pri teh bolnikih utegnejo biti potrebne prilagoditve odmerka (glejte poglavje 4.2).
It is important that the lowest effective dose is used for maintenance therapy.
Pomembno je, da za vzdrževalno zdravljenje uporabimo najnižji še učinkovit odmerek zdravila.
As a consequence of this interaction, lower plasma concentrations can occur, which could affect the efficacy of quetiapine therapy.
Kot posledica tega medsebojnega delovanja lahko pride do nižjih plazemskih koncentracij, kar lahko vpliva na učinkovitost zdravljenja s kvetiapinom.
Based on very limited data from published reports on quetiapine excretion into human breast milk, excretion of quetiapine at therapeutic doses appears to be inconsistent.
Na podlagi zelo omejenih podatkov iz objavljenih poročil o izločanju kvetiapina v materino mleko pri človeku kaže, da je izločanje kvetiapina v terapevtskih odmerkih nekonsistentno.
• Walking, talking , eating or other activities while you are asleep.
• hoja, govorjenje, uživanje hrane ali druge dejavnosti med spanjem,
Metabolic syndrome29
metabolični sindrom29
In both studies, patients with known lack of response to Seroquel were excluded.
Iz obeh študij so bili izključeni bolniki, za katere je bilo znano, da se ne odzovejo na zdravilo Seroquel.
Occurs predominantly during the early weeks of treatment in adults.
Pojavi se pretežno v prvih tednih zdravljenja pri odraslih.
This pack contains:
To pakiranje vsebuje:
For 3Day Starterpack pack size of 8 tablets is registered and for 4-Day Starterpack pack size of 10 tablets is registered.
Za 3-dnevno začetno pakiranje je registrirano pakiranje po 8 tablet in za 4-dnevno začetno pakiranje je registrirano pakiranje po 10 tablet.
(≥0.769 mmol/L) has been very commonly observed.
(≥ 0,769 mmol/l) je bilo opisano v zelo pogostih primerih.
Neutropenia 1
nevtropenija 1
• Body temperature decreased (hypothermia).
• znižana telesna temperatura (hipotermija),
Worsening in these parameters should be managed as clinically appropriate (see also section 4.8).
Poslabšanje teh parametrov je treba obravnavati, kot je klinično ustrezno (glejte tudi poglavje 4.8).
• Menstrual disorder.
• menstruacijske motnje,
In cases of quetiapine overdose, refractory hypotension should be treated with appropriate measures such as intravenous fluids and/or sympathomimetic agents.
V primerih prevelikega odmerjanja kvetiapina je treba refraktarno hipotenzijo zdraviti z ustreznimi ukrepi, npr. intravenskimi tekočinami in/ali simpatikomimetičnimi zdravili.
The administration of activated charcoal should be considered.
Lahko razmislimo tudi o uporabi aktivnega oglja.
The proportion of randomized patients over 75 years of age was 19%.
Delež randomiziranih bolnikov, starejših od 75 let, je bil
The following side effects have been seen more often in children and adolescents or have not been seen in adults:
Naslednji neželeni učinki so bili pri otrocih in mladostnikih pogostejši ali pri odraslih niso bili ugotovljeni:
Quetiapine is active in tests for antipsychotic activity, such as conditioned avoidance.
Kvetiapin je aktiven v testih antipsihotičnega delovanja, npr. pogojevanem izogibanju.
• Medicines that can cause constipation.
• zdravila, ki lahko povzročijo zaprtost.
This is further supported by the data from a positron emission tomography (PET) study, which identified that for quetiapine, 5HT2- and D2-receptor occupancy are maintained for up to 12 hours.
To dodatno podpirajo podatki študije s pozitronsko emisijsko tomografijo (PET), kjer so ugotovili, da so receptorji 5HT2 in D2 zasedeni s kvetiapinom do 12 ur.
These effects were apparent at maternal exposure levels similar or slightly above those in humans at the maximal therapeutic dose.
Ti učinki so bili opazni pri izpostavljenosti samic-mater, ki je bila podobna ali rahlo večja od izpostavljenosti pri človeku ob največjem terapevtskem odmerku.
(25) Based upon the increased rate of vomiting in elderly patients (≥65 years of age).
(25) Na podlagi večje pogostnosti bruhanja med starejšimi bolniki (starimi ≥ 65 let).
These elevations were usually reversible on continued quetiapine treatment.
Ta zvišanja so bila med nadaljevanjem zdravljenja s kvetiapinom ponavadi reverzibilna.
• Rapid swelling of the skin, usually around the eyes, lips and throat (angioedema).
• hitro otekanje kože, običajno okoli oči, ustnic in grla (angioedem),
Pharmacotherapeutic group: Antipsychotics ATC code: N05A H04
Farmakoterapevtska skupina: antipsihotiki Oznaka ATC: N05A H04
• Do not stop taking your tablets even if you feel better, unless your doctor tells you.
• Tudi če se počutite bolje, ne nehajte jemati tablet razen, če vam tega ne naroči zdravnik.
• Thoughts of suicide and worsening of your depression.
• razmišljanje o samomoru ali poslabšanje depresije,
The efficacy and safety of Seroquel was studied in a 3-week placebo controlled study for the treatment of mania (n= 284 patients from the US, aged 10-17).
Učinkovitost in varnost zdravila Seroquel so raziskali v 3-tedenski, s placebom kontrolirani študiji za zdravljenje manije (n = 284 bolnikov v ZDA, starih od 10 do 17 let).
Other psychiatric conditions for which quetiapine is prescribed can also be associated with an increased risk of suicide related events.
Druga psihiatrična stanja za katere se predpisuje kvetiapin so lahko tudi povezana s povečanjem tveganja za dogodke, povezane s samomorom.
The incidence of these reactions had decreased significantly after 1 week post-discontinuation.
Incidenca simptomov se je signifikantno zmanjšala po enem tednu po odtegnitvi.
There was no difference in magnitude of effect between the patients who received 300 mg Seroquel IR and those who received 600 mg dose.
Velikost učinka se ni razlikovala med bolniki, ki so dobivali 300 mg zdravila Seroquel, in tistimi, ki so dobivali odmerek 600 mg.
Note: The frequency is consistent to that observed in adults, but might be associated with different clinical implications in children and adolescents as compared to adults.
Opomba: Pogostnost se ujema z ugotovljeno pri odraslih, toda pri otrocih in mladostnikih ima lahko drugačne klinične posledice kot pri odraslih.
• Mania: where you may feel very excited, elated, agitated, enthusiastic or hyperactive or have poor judgment including being aggressive or disruptive.
• manije: ko se lahko počutite vzhičene, pretirano vesele, polne zanosa, entuziazma, ste hiperaktivni ali zmožni slabe presoje, vključno z agresivnostjo ali razdražljivostjo.
• Changes in the amount of certain fats (triglycerides and total cholesterol)
• spremembe koncentracije določenih maščob v krvi (trigliceridov in celokupnega holesterola).
The long-term efficacy of Seroquel IR in prevention of schizophrenic relapses has not been verified in blinded clinical trials.
Dolgoročna učinkovitost zdravila Seroquel za preprečevanje recidivov shizofrenije ni preverjena v slepljenih kliničnih preskušanjih.
Your doctor will decide on your starting dose.
Zdravnik bo odločil, kolikšen začetni odmerek potrebujete.
The effects of quetiapine on human fertility have not been assessed.
Učinki kvetiapina na plodnost pri človeku niso ugotovljeni.
Hypersensitivity (including allergic skin reactions)
Bolezni imunskega sistema preobčutljivost (vključno z alergijskimi kožnimi reakcijami)
These effects are related to elevated prolactin levels and not directly relevant to humans because of species differences in hormonal control of reproduction.
Ti učinki so povezani z zvišano koncentracijo prolaktina in za človeka niso neposredno pomembni zaradi razlik v hormonskem nadzoru reprodukcije med vrstama.
• Decrease in the amount of red blood cells
• zmanjšanje števila rdečih krvnih celic,
Confirmation of questionable immunoassay screening results by an appropriate chromatographic technique is recommended.
Priporoča se potrditev rezultatov encimskih preiskav s primerno kromatografsko tehniko.
Based on individual patient evaluation, if dose increase to 300 mg/day is required this should not be prior to Day 22 of treatment.
Če je na podlagi ocene posameznega bolnika odmerek treba povečati na 300 mg/dan, se tega ne sme narediti prej kot 22. dan zdravljenja.
Given the primary central nervous system effects of quetiapine, quetiapine should be used with caution in combination with other centrally acting medicinal products and alcohol.
Glede na primarne učinke kvetiapina na osrednji živčni sistem moramo biti previdni pri uporabi kvetiapina v kombinaciji z drugimi zdravili s centralnim delovanjem in pitjem alkohola.
• treatment of bipolar disorder:
• zdravljenje bipolarne motnje:
• Vomiting (mainly in the elderly).
• bruhanje (predvsem pri starejših),
The incidence of reciprocal, potentially clinically significant shifts of both T3 or T4 and TSH in these trials were rare, and the observed changes in thyroid hormone levels were not associated with clinically symptomatic hypothyroidism.
Incidenca recipročnih, potencialno klinično pomembnih sprememb T3 ali T4 in TSH je bila v teh preskušanjih majhna in opažene spremembe koncentracije ščitničnih hormonov niso bile povezane s klinično simptomatskim hipotiroidizmom.
This is most likely to occur within the first few weeks of treatment.
Pojav tega je najverjetnejši v prvih tednih zdravljenja.
Clinical trials have demonstrated that Seroquel is effective in schizophrenia and mania when given twice a day, although quetiapine has a pharmacokinetic half-life of approximately 7 hours.
Klinična preskušanja so pokazala, da je zdravilo Seroquel pri shizofreniji in maniji učinkovito pri uporabi dvakrat na dan, čeprav je farmakokinetična razpolovna doba kvetiapina približno 7 ur.
In addition, for 25 mg tablets pack size of 6 tablets is registered.
Dodatno je za jakost 25 mg registrirano tudi pakiranje po 6 tablet.
In clinical trials and use in accordance with the SPC, quetiapine was not associated with a persistent increase in absolute QT intervals.
V kliničnih preskušanjih in pri uporabi v skladu z SmPC, kvetiapin ni bil povezan s stalnim povečevanjem absolutnih intervalov QT.
(For cataracts/lens opacities see section 5.1).
(Za katarakte/zamotnitev očesne leče glejte poglavje 5.1).
• Worsening of pre-existing diabetes.
• poslabšanje obstoječe sladkorne bolezni.
Patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicine.
Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorbcijo glukoze/galaktoze ne smejo jemati tega zdravila.
It also blocks the action of dopamine agonists, measured either behaviourally or electrophysiologically, and elevates dopamine metabolite concentrations, a neurochemical index of D2-receptor blockade.
Blokira tudi delovanje agonistov dopamina (merjeno vedenjsko ali elektrofiziološko) in zvišuje koncentracijo presnovkov dopamina, ki so nevrokemični kazalci blokade receptorjev D2.
Approximately 73% of a radiolabelled drug was excreted in the urine and 21% in the faeces with less than 5% of the total radioactivity representing unchanged drug-related material.
Približno 73 % radioaktivno označenega zdravila se izloči v urinu in 21 % v blatu z manj kot 5 % skupne radioaktivnosti, ki predstavlja nespremenjeno snov povezano z zdravilom.
• Allergic reactions that may include raised lumps (weals), swelling of the skin and swelling around the mouth.
• alergijske reakcije, ki lahko vključujejo izbočene otekline (modrice), otekanje kože in predela okoli ust,
The elimination half lives of quetiapine and norquetiapine are approximately 7 and 12 hours, respectively.
Izločanje Razpolovni čas izločanja kvetiapina in norkvetiapina je približno 7 oziroma 12 ur.
Doses greater than 300 mg should be initiated by physicians experienced in treating bipolar disorder.
Odmerke višje od 300 mg lahko uvede zdravnik, ki ima izkušnje z zdravljenjem bipolarne motnje.
during their pregnancy
Motnje v času nosečnosti,
These may be increased when first starting treatment, since these medicines all take time to work, usually about two weeks but sometimes longer.
Po prvi uvedbi zdravljenja z antidepresivi lahko te misli postanejo še hujše, saj ta zdravila začnejo delovati šele čez nekaj časa, običajno čez dva tedna, nekatera pa tudi kasneje.
The symptoms of tardive dyskinesia can worsen or even arise after discontinuation of treatment (see Section 4.8).
Simptomi zapoznele diskinezije se lahko poslabšajo ali celo pojavijo po prenehanju zdravljenja (glejte poglavje 4.8).
Shifts in total T4, free T4, total T3 and free T3 are defined as <0.8 x LLN (pmol/L) and shift in TSH is > 5 mIU/L at any time.
Spremembe celotnega T4, prostega T4, celotnega T3 in prostega T3 so opredeljene kot < 0,8-kratna spodnja normalna meja (pmol/l) in sprememba TSH kot > 5 mIU/l kadarkoli.
During post-marketing experience, some cases were fatal.
V obdobju po prihodu zdravila na trg so se nekateri primeri končali s smrtjo.
Elderly people If you are elderly your doctor may change your dose.
Starejši bolniki Če ste starejši, vam zdravnik lahko spremeni vaš odmerek.
Exacerbation of preexisting diabetes
poslabšanje obstoječe sladkorne bolezni
• Breakdown of muscle fibers and pain in muscles (rhabdomyolysis).
• propad mišičnih vlaken in bolečine v mišicah (rabdomioliza),
(18) Incidence of patients who have a QTc shift from <450 msec to ≥450 msec with a ≥30 msec increase.
(18) Pojav bolnikov, ki imajo spremembo QTc iz < 450 msek na ≥ 450 msek z ≥30 msek povečanjem.
• Abnormal dreams and nightmares
• nenavadne sanje in nočna mora,
Seroquel with food, drink and alcohol
Zdravilo Seroquel skupaj s hrano, pijačo in alkoholom
Cardiomyopathy and Myocarditis
Kardiomiopatija in miokarditis
The data showed an additive effect at week 3.
Podatki so v 3. tednu pokazali aditivni učinek.
Seroquel can be used to treat several illnesses, such as:
Zdravilo Seroquel se lahko uporablja za zdravljenje več bolezni, npr.:
• A severe allergic reaction (called anaphylaxis) which may cause difficulty in breathing or shock.
• huda alergijska reakcija (imenovana anafilaksija), ki lahko povzroči težave pri dihanju ali šok,
• Blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing.
• krvni strdki v žilah, zlasti v nogah (simptomi so oteklina, bolečina in rdečina na nogi), ki lahko potujejo skozi krvne žile v pljuča in povzročajo bolečine v prsih ter težave z dihanjem.
• add-on treatment of major depressive episodes in patients with Major Depressive Disorder (MDD) who have had sub-optimal response to antidepressant monotherapy (see Section 5.1).
• kot dodatno zdravljenje velikih depresivnih epizod pri bolnikih z veliko depresivno motnjo (MDD - Major Depressive Disorder), ki so imeli suboptimalni odziv na antidepresivno monoterapijo (glejte poglavje 5.1).
Clinical efficacy:
Klinična učinkovitost:
(32) May occur at or near initiation of treatment and be associated with hypotension and/or syncope.
(32) Lahko se pojavi ob uvedbi zdravljenja ali kmalu po njej in jo lahko spremljata hipotenzija in/ali sinkopa.
Neutropenia should be considered in patients presenting with infection or fever, particularly in the absence of obvious predisposing factor(s), and should be managed as clinically appropriate.
Na nevtropenijo je treba pomisliti pri bolnikih, ki imajo okužbo ali zvišano telesno temperaturo, zlasti če nimajo očitnih predispozicijskih dejavnikov; nevtropenijo je treba obravnavati, kot je klinično primerno.
These data do not establish a causal relationship between quetiapine treatment and death in elderly patients with dementia.
Ti podatki ne dokazujejo vzročne povezanosti med zdravljenjem s kvetiapinom in smrtjo pri starejših bolnikih z demenco.
In comparison, a light meal had no significant effect on the Cmax or AUC of quetiapine.
V primerjavi s tem lahek obrok ni značilno vplival ne na Cmax ne na AUC kvetiapina.
Patients (and caregivers of patients) should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.
Bolnike (in skrbnike bolnikov) je treba opozoriti, da morajo biti pozorni na kakršnokoli klinično poslabšanje, samomorilno vedenje ali razmišljanje in na neobičajne vedenjske spremembe.
A second study did not demonstrate an additive effect at week 6.
Druga študija ni pokazala aditivnega učinka po 6 tednih.
Epinephrine and dopamine should be avoided, since beta stimulation may worsen hypotension in the setting of quetiapine-induced alpha blockade.
Adrenalinu in dopaminu se je treba izogniti, ker lahko beta-stimulacija v primeru alfa-blokade s kvetiapinom poslabša hipotenzijo.
• Sexual dysfunction.
• spolne motnje,
• You know that you have had low levels of white blood cells in the past (which may or may not have been caused by other medicines).
• veste, da ste v preteklosti imeli nizko število belih krvnih celic, ki bi ga lahko ali pa tudi ne,
The average molar dose fraction of free quetiapine and the active human plasma metabolite norquetiapine is <5% excreted in the urine.
Povprečni molarni delež odmerka prostega kvetiapina in norkvetiapina, aktivnega presnovka v človeški plazmi, je < 5 % izločen v urinu.