natgillin/translations-raw huggingface dataset:
The European Medicines Agency noted that Votubia has been shown to reduce the size of the brain tumours in adults and children with tuberous sclerosis and that this is expected to reduce the signs and symptoms of SEGA such as seizures, hydrocephalus (accumulation of fluid in the brain), and increased pressure within the brain.
Evropska agencija za zdravila je menila, da je bilo dokazano, da zdravilo Votubia zmanjšuje velikost možganskih tumorjev pri odraslih in otrocih s tuberozno sklerozo, s čimer naj bi pripomoglo k zmanjšanju znakov in simptomov subependimskega gigantoceličnega astrocitoma, kot so epileptični napadi, hidrocefalus (nabiranje tekočine v možganih) in povišan tlak v možganih.
For more information about using Votubia, see the package leaflet or contact your doctor or pharmacist.
Za več informacij glede uporabe zdravila Votubia glejte navodilo za uporabo ali se posvetujte z zdravnikom ali farmacevtom.
The second study involved 117 patients (including 20 children aged below 3 years) and compared Votubia with placebo (a dummy treatment).
V drugi študiji je sodelovalo 117 bolnikov (vključno z 20 otroki, mlajšimi od treh let), v njej pa so zdravilo Votubia primerjali s placebom (zdravilom brez zdravilne učinkovine).
In SEGA caused by tuberous sclerosis, Votubia has been studied in two main studies: the first study involved 28 adults and children aged three years and above.
Zdravilo Votubia so pri bolnikih s subependimskim gigantoceličnim astrocitomom, ki ga povzroča tuberozna skleroza, proučevali v dveh glavnih študijah: v prvo je bilo vključenih 28 odraslih in otrok, starejših od treh let.
The side effects of the medicine were considered to be manageable and were generally mild or moderate.
Neželeni učinki tega zdravila, ki so na splošno blagi ali zmerni, so bili ocenjeni kot obvladljivi.
The benefits of Votubia as an add-on treatment of partial onset seizures related to tuberous sclerosis that have not been sufficiently controlled by other treatments have been shown in one main study.
Koristi zdravila Votubia kot dodatka k zdravljenju napadov parcialnega izvora, povezanih s tuberozno sklerozo, ki niso bili ustrezno uravnani z drugimi zdravljenji, so bile predstavljene v eni glavni študiji.
• subependymal giant cell astrocytoma (SEGA), a benign tumour of the brain, where it is used in adults and children whose brain tumour cannot be surgically removed;
• subependimskega gigantoceličnega astrocitoma (SEGA), tj. benignega možganskega tumorja, pri odraslih in otrocih, pri katerih tumorjev ni mogoče odstraniti s kirurškim posegom;
For SEGA, and for use as add-on treatment of seizures, the starting dose depends on the body surface area (calculated using the patient's height and weight) and the patient's age, but the doctor will adjust the dose based on the patient's blood levels of the medicine and how well the patient tolerates the medicine.
Začetni odmerek pri subependimskem gigantoceličnem astrocitomu in kadar se uporablja kot dodatek k zdravljenju je odvisen od bolnikove telesne površine (izračunane na podlagi njegove telesne višine in mase) in bolnikove starosti, vendar ga zdravnik lahko prilagodi glede na koncentracijo zdravila v krvi bolnika in glede na to, kako dobro ga ta prenaša.
The main measure of effectiveness was the proportion of patients who responded to treatment and whose kidney tumour shrank by at least half, which was seen in 42% of patients (33 out of 79) treated with Votubia, compared with none of the 39 patients who received placebo.
Glavno merilo učinkovitosti je bil delež bolnikov, ki so se odzvali na zdravljenje in katerih ledvični tumor se je zmanjšal vsaj za polovico, kar je bilo opaženo pri 42 % (33 od 79) bolnikov, zdravljenih z zdravilom Votubia, medtem ko med 39 bolniki, ki so prejemali placebo, do tega ni prišlo pri nobenem bolniku.
Starting doses may need to be reduced, or treatment avoided, in patients with reduced liver function, depending on how severe this is and on the patient's age and the condition they are being treated for.
Pri bolnikih z okvaro delovanja jeter bo začetni odmerek morda treba zmanjšati ali se zdravljenju izogniti, odvisno od resnosti težave ter od starosti in stanja bolnika, zaradi katerega se zdravi.
This occurred in 35% of patients (27 out of 78 patients) treated with Votubia, compared with none of the 39 patients who received placebo.
Do tega je prišlo pri 35 % (27 od 78) bolnikov, zdravljenih z zdravilom Votubia, medtem ko med 39 bolniki, ki so prejemali placebo, do tega ni prišlo pri nobenem bolniku.
The medicine is also used as an add-on treatment in patients from 2 years of age with seizures (fits) related to tuberous sclerosis that have not responded to other treatments.
Zdravilo se uporablja tudi kot dodatek k zdravljenju pri bolnikih od drugega leta starosti z napadi, povezanimi s tuberozno sklerozo, ki se niso odzvali na druga zdravljenja.
The active substance in Votubia, everolimus, is an anti-tumour medicine that acts by blocking an enzyme called ‘mammalian target of rapamycin' (mTOR), which has increased activity in tumour cells of patients with SEGA or renal angiomyolipoma.
Zdravilna učinkovina zdravila Votubia, everolimus, je protitumorsko zdravilo, ki deluje tako, da zavira delovanje encima, imenovanega „tarča rapamicina pri sesalcih“(mTOR), ki v tumorskih celicah pri bolnikih s subependimskim gigantoceličnim astrocitomom ali ledvičnim angiomiolipomom deluje s povečanim delovanjem.
For the full list of all side effects reported with Votubia, see the package leaflet.
Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Votubia, glejte navodilo za uporabo.
How is Votubia used?
Kako se zdravilo Votubia uporablja?
How does Votubia work?
Kako zdravilo Votubia deluje?
Overall, the patients given Votubia had a 29 and 40% reduction respectively in the number of seizures during treatment, compared with a 15% reduction in those given placebo.
Pri bolnikih, ki so prejemali zdravilo Votubia, je med zdravljenjem prišlo do 29 % oziroma 40 % zmanjšanja števila napadov, v primerjavi s 15 % zmanjšanjem števila napadov pri tistih, ki so jemali placebo.
• renal angiomyolipoma, a benign tumour of the kidneys, where it is used in adults who are at risk of complications but who do not require immediate surgery.
• ledvičnega angiomiolipoma, tj. benignega tumorja ledvic, pri odraslih, ki so izpostavljeni tveganju za pojav zapletov, vendar takojšnji kirurški poseg pri njih ni potreben.
Votubia has been shown to be effective at treating patients with SEGA and renal angiomyolipoma by shrinking the volume of the tumours.
Zdravilo Votubia se je izkazalo kot učinkovito pri zdravljenju bolnikov s subependimskim gigantoceličnim astrocitomom in ledvičnim angiomiolipomom, saj je vplivalo na zmanjšanje velikosti tumorjev.
Although surgery remains the standard treatment for this condition, Votubia is expected to benefit patients whose tumour cannot be operated on. Votubia has also been shown to reduce the size of kidney tumours in patients with renal angiomyolipoma and has been shown to be beneficial as an add-on treatment in the management of partial-onset seizures related to tuberous sclerosis that have not sufficiently responded to other therapy.
Čeprav se ta bolezen običajno zdravi s kirurškim posegom, se pričakuje, da bo zdravilo Votubia koristilo bolnikom, pri katerih tumorja ni mogoče operirati.
This estimate has not been independently verified.
Ta ocena ni bila neodvisno preverjena.
Some of these cases required hospitalisation.
V nekaterih primerih je bila potrebna hospitalizacija.
Also the situation is dynamic and may change as new cases arise.
Prav tako je situacija dinamična in se lahko spremeni z odkritjem novih primerov.
• Avoid contact with eyes.
• Preprečite stik z očmi.
Maintaining the status quo
Ohranjanje statusa quo
Secondly, re-formulation would necessitate new quality, safety and efficacy studies, which might not be feasible.
Drugič, reformulacija bi zahtevala nove raziskave kakovosti, varnosti in učinkovitosti, ki morda niso izvedljive.
- the Committee assessed the information provided by the Marketing Authorisation Holders in response to the list of questions agreed by the Committee on 16 June 2004 and the additional information provided on 12 July 2005;
- Odbor je ovrednotil podatke, ki so jih predložili imetniki dovoljenja za promet kot odgovor na seznam vprašanj, o katerih se je Odbor sporazumel 16. junija 2004, in dodatne podatke, ki so bili predloženi 12. julija 2005;
Other combinations of measures would theoretically be possible, but would not present significant additional benefits to risk management, and they are therefore not discussed.
Druge kombinacije ukrepov bi teoretično bile možne, vendar ne predstavljajo znatnih dodatnih koristi k upravljanju tveganja, zato o njih ni bilo razprave.
OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF MICOTIL (see Annex I)
ZAKLJUČNI POVZETEK ZNANSTVENEGA VREDNOTENJA ZDRAVILA MICOTIL (glejte Dodatek I)
• Ensure that animals are properly restrained, including those in the vicinity.
• Zagotovite, da je žival ustrezno zadržana, prav tako morajo biti zadržane živali v bližini.
They tend to be physically active and involved in handling animals every day.
So telesno dejavni in ravnajo z živalmi vsak dan.
90027 Bernolakova, Slovak Republic
90027 Bernolakova, Slovaška
D-35396 Gießen
D-35396 Gießen Nemčija
Cattle and calves up to 2 years of age;
Govedo in teleta do 2 let starosti;
Harmonised, stringent user safety warnings would include:
Usklajena obvezna varnostna opozorila za uporabnike bi vključevala:
Survival rates are greatly improved by the correct medical intervention.
Stopnjo preživetja zelo izboljša pravilna zdravniška pomoč.
In addition this measure would bear a high risk of being ignored.
Poleg tega bi ta ukrep povečal tveganje ignoriranja ukrepa.
A statement in a frame with yellow background colour, saying:
Izjava v okvirju z rumeno podlago in naslednjim besedilom:
Accurate weighing of lambs is important to avoid overdosage.
Natančno tehtanje jagenj je pomembno, da preprečite prekomerno odmerjanje.
It is evident that accidental injections may occur, but normally the volume injected is low.
Razvidno je, da do nenamernega injiciranja lahko pride, vendar je običajno injicirani volumen majhen.
Stawki no. 2, 21 pietro 00-193 Warsaw Poland
Stawki no. 2, 21 pietro 00-193 Warsaw Poljska
The product has a relatively long history of use with few questions over its effectiveness in the field.
Zdravilo ima v praksi relativno dolgo zgodovino uporabe z le nekaj dvomi o njegovi učinkovitosti.
Under paragraph 5.1 “Pharmacodynamic properties”
Pod točko 5.1 „Farmakodinamične lastnosti“
As tilmicosin persists in tissues for several days, the cardiovascular system should be closely monitored and supportive treatment provided.
Ker tilmikozin vztraja v tkivih več dni, je potrebno srčno-žilni sistem skrbno nadzorovati in nuditi podporno zdravljenje.
ANNEX IV CONDITIONS OF THE MARKETING AUTHORISATION
DODATEK IV POGOJI DOVOLJENJA ZA PROMET
- The educational measures for the user are a prerequisite to ensure appropriate adherence to the safety warnings.
- Izobraževalni ukrepi za uporabnike so predpogoj za zagotovitev primerne doslednosti pri upoštevanju varnostnih opozoril.
Under paragraph 4.4 “Special warnings for each target species”
Pod točko 4,4 „Posebna opozorila za vsako ciljno živalsko vrsto“
Cattle Sheep (over 15kg)
Govedo Ovce (težje od 15 kg)
In total 520 human exposures were reported since 1999, of which 509 were accidental.
Skupno so od leta 1999 poročali o 520 izpostavitvah človeka, od tega je bilo 509 izpostavitev nenamernih.
Do not inject lambs weighing less than 15 kg, since there is a real risk of overdose toxicity.
Ne injicirajte jagnjem lažjim od 15 kg, saj obstaja resnično tveganje toksičnosti čezmernega odmerka.
In the opinion of the CVMP, this is not a solution in view of the potential risk of accidental fatalities in human beings.
Po mnenju CVMP to ni rešitev zaradi potencialnega tveganja nezgodnih smrtnih primerov pri ljudeh.
“Special precautions to be taken by the person administering the medicinal product to animals”
„Posebni varnostni ukrepi, ki jih mora izvajati oseba, ki daje zdravilo živalim“
Of these 509 reports, 214 cases related to non-injection exposures, and 295 to injection exposures, with minor needle scratches being the most common.
Od teh 509 poročil je bilo 214 primerov povezanih z izpostavitvijo brez injiciranja in 295 primerov povezanih z izpostavitvijo z injiciranjem, pri čemer so bile najpogostejše manjše praske z iglo.
Discussion of risk management options
Razpravljanje o možnostih upravljanja tveganja
INJECTION OF THIS DRUG IN HUMANS HAS BEEN ASSOCIATED WITH FATALITIES.
INJICIRANJE TEGA ZDRAVILA V ČLOVEKA JE POVEZANO S SMRTNIMI PRIMERI.
Nevertheless, it is necessary to put in practice some measures to reduce the risks of accidental self-injection.
Kljub temu je treba v praksi začeti uresničevati nekatere ukrepe za zmanjšanje tveganja nenamernega samoinjiciranja.
Additional data were provided in relation to 4 studies on the likely action mechanism of tilmicosin on the heart function and on possible remedial measures.
Predloženi so bili podatki v zvezi s 4 raziskavami o verjetnem mehanizmu delovanja tilmikozina na srce in o možnih ukrepih za zdravljenje.
ANNEX II SCIENTIFIC CONCLUSIONS AND GROUNDS FOR AMENDMENT OF THE SUMMARY OF PRODUCT CHARACTERISTICS PRESENTED BY THE EMEA
DODATEK II ZNANSTVENI ZAKLJUČKI IN PODLAGE ZA DOPOLNITEV POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA, KI JIH ZASTOPA EMEA
Withdrawal of the product from the market in the EU
Umik zdravila iz prometa v EU
However, evidence based data to demonstrate the benefits of Micotil relative to other authorised antibacterials has not been provided.
Vendar podatki na osnovi dokazov, s katerimi bi bile prikazane koristi zdravila Micotil relativno na ostala odobrena protibakterijska sredstva, niso bili predloženi.
However, it is not possible on the basis of available evidence, to estimate a dose without adverse effects in human beings.
Vendar na podlagi dostopnih dokazov ni možno oceniti odmerka brez neželenih učinkov pri človeku.
Given the diversity of farming conditions throughout the different EU Member States concerned by the referral, the various capabilities of farmers in the EU Member States concerned, as well as the recent trends in farming of more suckler animals and scarcity of labour in some EU Member States, the CVMP does not concur with the view of the representative of the MAHs that all ‘professional' farmers may be regarded as experienced and competent.
Glede na raznolikost pogojev kmetovanja po državah članicah EU, ki jih zadeva postopek napotitve, različne zmogljivosti kmetov v zadevnih članicah EU ter nedavne trende v pretežnejši reji dojilj in pomanjkanje dela v nekaterih državah članicah EU, CVMP ne soglaša s pogledom predstavnika imetnikov dovoljenj za promet, da imamo lahko vse „profesionalne“ kmete za izkušene in usposobljene.
Tilmicosin was found to dosedependently reduce ICa amplitude with an IC50 value of 26.75 µM.
Ugotovili so, da tilmikozin v odvisnosti od odmerka zmanjša amplitudo ICa z vrednostjo IC50 26,75 uM.
Very rarely the volume is higher than 1-2 ml and it is improbable that a fatality will occur.
Zelo redko je volumen večji od 1-2 ml in smrtni primeri niso verjetni.
The risk : benefit analysis for Micotil is rather complex and various risk management proposals must be carefully considered.
Analiza tveganja in koristi zdravila Micotil je precej zapletena, zato je treba natančno upoštevati različne predloge upravljanja s tveganjem.
Veterinary surgeons have specific training in drug safety, clinical medicine, animal husbandry, restraining and handling of animals.
Veterinarji so specifično usposobljeni na področjih varnosti zdravil, klinične medicine, živinoreje, zadržanja in ravnanja z živalmi.
Single dose All sheep indications and pneumonia in cattle:
En odmerek Vse indikacije pri ovcah in pljučnica pri govedu:
It is appreciated that this action would reduce the therapeutic armoury available for the effective treatment of diseases in animals.
Ocenjeno je bilo, da bi ta ukrep zmanjšal terapevtske možnosti za učinkovito zdravljenje bolezni pri živalih.
ELANCO ELLAS Messogion 335 Av, 15231 Athens Greece
ELANCO ELLAS Messogion 335 Av, 15231 Athens Grčija
In view of the benefits afforded by the product as set out above and on the basis of the evidence provided by the representative of the MAHs the CVMP is of the opinion that this approach is however not proportionate.
Ob upoštevanju koristnih učinkov zdravila, ki so opredeljeni zgoraj, in na podlagi dokazov, ki jih je predložil predstavnik imetnikov dovoljenj za promet, je CVMP mnenja, da ta pristop ni sorazmeren.
Boehringer Ingelheim Vetmedica GmbH Binger Strasse 173 55216 Ingelheim Germany
Boehringer Ingelheim Vetmedica GmbH Binger Strasse 173 55216 Ingelheim Nemčija
Administration of dobutamine should also be considered due to its positive inotropic effects although it does not influence tachycardia.
Upoštevati je treba tudi možnost dajanja dobutamina zaradi njegovih pozitivnih inotropnih učinkov, čeprav ne vpliva na tahikardijo.
DO NOT GIVE ADRENALIN OR BETA-ADRENERGIC ANTAGONISTS SUCH AS PROPRANOLOL.
NE DAJAJTE ADRENALINA ALI ZAVIRALCEV BETA-ADRENERGIČNIH RECEPTORJEV, KOT JE PROPRANOLOL.
As the dosage of the product in adult sheep is typically 1-5 ml and in adult cattle is typically 15-20 ml, it is difficult to accurately estimate the incidence of human reactions or fatalities.
Ker je odmerek zdravila pri odraslih ovcah ponavadi 1-5 ml, pri odraslem govedu pa ponavadi 15-20 ml, je težko natančno oceniti pojavnost reakcij in smrtnih primerov pri ljudeh.
These results suggest that intravenous epinephrine may be contraindicated.
Ti rezultati kažejo, da je intravensko dajanje epinefrina morda kontraindicirano.
RG21 6XA United Kingdom
RG21 6XA Združeno kraljestvo
Overall, the CVMP considers the risks inherent to this option would be the lowest.
Na podlagi vsega naštetega CVMP smatra, da bodo tveganja pri tej možnosti najmanjša.
Additional recommendation to any of the options 3. to 5. regarding limitation of the volume of Micotil to be held per syringe or of maximum pack size or re-formulation of the product
Dodatna priporočila k možnostim 3 do 5 glede omejitev volumna zdravila Micotil na brizgo, največjega pakiranja ali reformulacije zdravila
Such cardiotoxic effects have also been observed in human beings (mainly after intentional injection but in 2 known cases outside the EU after accidental injection of Micotil).
Te kardiotoksične učinke so opazili tudi pri ljudeh (predvsem po namernem injiciranju, vendar tudi v 2 znanih primerih nenamernega injiciranja zdravila Micotil izven EU).
The benefits of treatment with Micotil include that the animal is treated with an effective antibacterial.
Korist zdravljenja z zdravilom Micotil je med drugim tudi, da se žival zdravi z učinkovitim protibakterijskim sredstvom.
Evidence from investigations of 13 occurrences of intentional intramuscular injection suggests that 60% of people who received 10 to 12 ml of Micotil died.
Raziskava 13 primerov namernega intramuskularnega injiciranja kaže, da umre 60 % oseb, ki prejmejo 10 do 12 ml zdravila Micotil.
Apply a cold pack (not ice directly) to the injection site.
Na mesto vbrizganja položite hladen obkladek (ledu ne polagajte neposredno).
While reducing the maximum amount available for accidental injection of the user, this measure would increase the chances for accidental exposure of human beings.
Kljub zmanjšanju največje količine, ki bi bila uporabniku na voljo za nenamerno injiciranje, bi ta ukrep povečal verjetnosti nenamerne izpostavitve ljudi.
Tilmicosin is an antimicrobial substance that is not used in human medicine and resistance in human bacteria to tilmicosin is very low (source: DANMAP).
Tilmikozin je protimikrobno sredstvo, ki se v humani medicini ne uporablja in je odpornost pri bakterijah človeka zelo redka (vir: DANMAP).
Do not inject more than 20 ml per injection site.
Ne vbrizgajte več kot 20 ml pripravka na enem mestu vbrizganja.
For the EU the average bovine weight was put on 150 kg (90% of the sales) whereas the average ovine weight was kept at 30 kg.
Za EU je bila upoštevana povprečna telesna masa govedi 150 kg (90 % prodaje), povprečna masa ovac pa je ostala 30 kg.
This option bears the following inherent risk:
Ta možnost predstavlja naslednje tveganje:
Thirdly, re-formulation to a lower strength product might not lead to a tangible risk reduction as the dose causing adverse effects in human beings is not known and is expected to vary depending on the physical condition of the individual.
Tretjič, reformulacija v šibkejšo obliko morda ne bo realno zmanjšala tveganja, saj odmerek, ki povzroča neželene učinke pri ljudeh ni znan, pričakuje pa se, da je odvisen od telesne kondicije posameznika.
Interdigital necrobacillosis in cattle:
Interdigitalna nekrobaciloza pri govedu:
The risk of serious signs of toxicity and death in human beings appear to be linked to plasma concentrations around 5 µg/ml, whereas plasma concentrations of 1-2 µg/ml did not lead to fatalities.
Izgleda, da je tveganje hudih znakov toksičnosti in smrti pri ljudeh povezano s plazemskimi koncentracijami približno 5 µg/ml, plazemske koncentracije 1-2 µg/ml pa niso povzročile smrti.
- the Committee considered the referral made under Article 35 of Directive 2001/82/EC in the interest of the Community regarding user safety for national marketing authorisations for Micotil or variations of that name as listed in Annex I of the opinion;
- Odbor je preučil postopek napotitve po členu 35 Direktive 2001/82/ES v interesu Skupnosti glede varnosti uporabnika v nacionalnih dovoljenjih za promet zdravila Micotil ali variacij tega imena iz Dodatka 1 mnenja;
This option bears the following inherent risks:
Ta možnost predstavlja naslednja tveganja:
Recognising that farming practices in the USA, where the accidental fatalities were reported, differ significantly from farming practices in the EU different risk management approaches between the USA and the EU may be required.
Ob upoštevanju, da se kmetovanje v ZDA, kjer sta bila zabeležena nezgodna smrtna primera, znatno razlikuje od kmetovanja v EU, se bo morda moral pristop k upravljanju tveganja v EU razlikovati od tistega v ZDA.
Bearing the aforesaid in mind, based on the data provided by the representative of the MAHs on world-wide sales of Micotil since 1999 and the 2 cases of accidental fatal injections in human beings reported to date in the USA, the risk of an accidental human fatality may be estimated as less than 1 per 60 million administrations1.
Upoštevajoč navedeno in na podlagi podatkov, ki jih je predložil predstavnik imetnikov dovoljenj za promet, o svetovni prodaji zdravila Micotil od leta 1999 in 2 doslej ugotovljenih primerih nenamernega smrtnega injiciranja v ZDA, je tveganje nezgodne smrti pri ljudeh ocenjeno na manj kot 1 na 60 milijonov odmerjanj1.
Withdraw the required dose from the vial and remove the syringe from the needle.
Odmerite zahtevan odmerek iz viale in snemite brizgo iz igle.
In the two accidental fatalities recorded to date the victims were farmers and in both treatment of the adverse reactions involved use of adrenaline (epinephrine), which is considered as contra-indicated in cases of human exposure to tilmicosin.
V dveh nezgodnih smrtnih primerih ugotovljenih do sedaj, sta bila žrtvi kmeta in v obeh primerih je bil pri zdravljenju neželenih reakcij uporabljen adrenalin (epinefrin), ki je kontraindiciran v primerih človeške izpostavitve tilmikozinu.
Micotil is a single-injection, low volume treatment and therefore has benefits of ease of use, animal welfare and compliance with dosage regimen.
Zdravilo Micotil je za enkratno injiciranje z majhnim volumnom in zato ima koristi enostavne uporabe, blagostanja živali in doslednega upoštevanja sheme uporabe.
A related risk is that certain substances, in particular adrenaline (epinephrine), used in standard emergency treatment in human medicine may exacerbate the effects of tilmicosin.
Povezano tveganje predstavljajo določene snovi, zlasti adrenalin (epinefrin), ki se uporabljajo v standardnem nujnem zdravljenju v humani medicini, ker lahko poslabšajo učinke tilmikozina.