natgillin/translations-raw huggingface dataset:
Your doctor will use blood tests and/or an ultrasound machine to check when this is.
Vaš zdravnik bo s krvnimi preiskavami in/ali ultrazvočnim pregledom ugotovil nastop želenega stanja.
Follitropin alfa should be given at a dose of 150 IU three times a week, concomitantly with hCG, for a minimum of 4 months.
Folitropin alfa se mora dajati v odmerku 150 i.e., trikrat na teden, sočasno s hCG, najmanj štiri mesece.
Such patients are unresponsive to follitropin alfa/hCG therapy.
Takšni bolniki se na zdravljenje s folitropinom alfa/hCG ne odzivajo.
Driving and using machines It is not expected that this medicine will affect your ability to drive and use machines.
Ne pričakuje se, da bi zdravilo vplivalo na sposobnost vožnje ali upravljanja strojev.
• Your dose of Bemfola may be increased every 7 or every 14 days by 37.5 to 75 IU, until you get the desired response.
• Vaš odmerek zdravila Bemfola se lahko poveča vsakih 7 ali 14 dni za 37,5 do 75 i.e., dokler ne boste dosegli želenega odziva.
Before you start using your pre-filled pen
Preden začnete uporabljati svoj napolnjeni injekcijski peresnik
• Give yourself the injection around the same time each day.
• Zdravilo si injicirajte vsak dan ob približno istem času.
If your doctor decides to try Bemfola treatment, to monitor the treatment, they may ask you to provide semen for analysis 4 to 6 months after starting treatment.
Če se zdravnik odloči, da vas bo poskusil zdraviti z zdravilom Bemfola, vas bo za spremljanje vašega zdravljenja štiri do šest mesecev po začetku zdravljenja prosil za vzorce sperme za analizo.
• primary ovarian failure;
• primarna odpoved jajčnikov;
Severe OHSS (including associated symptomatology) (see section 4.4)
hud OHSS (vključno s povezanimi simptomi) (glejte poglavje 4.4)
Use the prefilled pen only once then it should be disposed of in a safe manner.
Napolnjeni injekcijski peresnik uporabite samo enkrat, potem pa ga na varen način zavrzite.
After the injection
Po injiciranju
Do not use Bemfola
Ne uporabljajte zdravila Bemfola
• gynaecological haemorrhages of unknown aetiology;
• ginekološka krvavitev neznane etiologije;
• Allergic reactions such as rash, red skin, hives, swelling of your face with difficulty breathing can sometimes be serious.
• Alergijske reakcije, kot so izpuščaj, pordela koža, koprivnica in oteklost obraza s težavami pri dihanju, so včasih lahko resne.
Follitropin alfa should not be used when an effective response cannot be obtained.
Folitropina alfa ne smete uporabljati, kadar ni mogoče doseči učinkovitega odziva.
What Bemfola is and what it is used for What you need to know before you use Bemfola How to use Bemfola
Kaj je zdravilo Bemfola in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Bemfola Kako uporabljati zdravilo Bemfola
• The first injection of Bemfola should be given under supervision of your doctor.
• Prvo injekcijo zdravila Bemfola si morate dati pod nadzorom zdravnika.
Turn the dosage knob until your prescribed dose is in line with the display window.
Obračajte gumb za nastavitev odmerka, dokler vaš predpisani odmerek ni uravnan z okencem za prikaz odmerka.
Comparative clinical trials have shown that on average patients require a lower cumulative dose and shorter treatment duration with follitropin alfa compared with urinary FSH.
Primerjalna klinična preskušanja so pokazala, da potrebuje bolnik v povprečju nižji skupni odmerek in krajše trajanje zdravljenja s folitropinom alfa kot z urinarnim FSH.
Down-regulation with a gonadotropin-releasing hormone (GnRH) agonist or antagonist is now commonly used in order to suppress the endogenous LH surge and to control tonic levels of LH.
Negativna povratna regulacija z agonistom ali antagonistom gonadotropin sproščajočega hormona (GnRH) se danes že običajno uporablja za zaviranje porasta endogenega LH in za kontroliranje toničnih ravni LH.
Clinical assessment of follitropin alfa indicates that its daily doses, regimens of administration and treatment monitoring procedures should not be different from those currently used for urinary FSH-containing medicinal products.
da njegovi dnevni odmerki, režim uporabe in postopki nadzorovanja zdravljenja ne bi smeli biti drugačni od tistih, ki se trenutno uporabljajo za zdravila z urinarnim FSH.
In case of exposure during pregnancy, clinical data are not sufficient to exclude a teratogenic effect of follitropin alfa.
Klinični podatki pri nosečnicah, izpostavljenih zdravilu, ne zadoščajo za izključitev teratogenih učinkov folitropina alfa.
The safety and efficacy of follitropin alfa in elderly patients have not been established.
Varnost in učinkovitost folitropina alfa pri starejših bolnikih nista bili dokazani.
Follitropin alfa is indicated for use in infertility (see section 4.1).
Plodnost Folitropin alfa je indiciran za uporabo pri neplodnosti (glejte poglavje 4.1).
Push in the dosage knob slowly and continuously until it stops, and the dose bar has disappeared.
Počasi in neprekinjeno potiskajte gumb za nastavitev odmerka navznoter, dokler se ne zaustavi in črtica za odmerjanje izgine.
Getting your pre-filled pen ready for injection 4.
Priprava vašega napolnjenega injekcijskega peresnika za injiciranje 4.
Store in a refrigerator.
POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte v hladilniku.
If a patient fails to respond adequately after 4 weeks of treatment, that cycle should be abandoned and the patient should undergo further evaluation after which she may recommence treatment at a higher starting dose than in the abandoned cycle.
Če pri bolnici ni zadovoljivega odziva na zdravljenje po štirih tednih, se mora ta ciklus zdravljenja opustiti, bolnico ponovno oceniti, nato pa bo morda morala ponovno zdravljenje začeti z večjim začetnim odmerkom kot v opuščenem ciklusu.
After the withdrawal of the needle: clean the skin with an alcohol swab using a circular motion.
Po odstranitvi igle: s krožnimi gibi očistite kožo z alkoholnim zložencem.
• Bemfola is presented as a clear, colourless liquid for injection in a pre-filled pen (injection).
• Zdravilo Bemfola je na voljo v obliki bistre, brezbarvne tekočine za injiciranje v napolnjenem injekcijskem peresniku (injekciji).
In patients undergoing ovulation induction, the incidence of a multiple pregnancy is increased compared with natural conception.
Pri bolnicah v postopku indukcije ovulacije je pogostnost večplodne nosečnosti v primerjavi z naravno zanositvijo povečana.
When undergoing assisted reproductive technology or stimulation of your ovaries to produce eggs, you are more likely to have a miscarriage than the average woman.
Splav Pri postopkih asistirane reprodukcije ali stimulacije jajčnikov za tvorbo jajčec je bolj verjetno, da bo prišlo do splava kot pri povprečnih ženskah.
• together with another medicine called “lutropin alfa” (“luteinising hormone” or LH) to help release an egg from the ovary (ovulation) in women that are not ovulating because their body is producing very little gonadotropins (FSH and LH).
• skupaj z drugim zdravilom, ki se imenuje „lutropin alfa“ („luteinizirajoči hormon“ ali LH) in pomaga pri sproščanju jajčeca iz jajčnika (ovulaciji) pri tistih ženskah, ki nimajo ovulacije, ker njihovo telo proizvaja zelo malo gonadotropinov (FSH in LH);
When using Bemfola, you have a higher risk of being pregnant with more than one child at the same time (“multiple pregnancy”, mostly twins), than if you conceive naturally.
Pri uporabi zdravila Bemfola je tveganje za nosečnost z več plodi večja („večplodna nosečnost“, običajno dvojčki) kot pri naravni zanositvi.
No direct comparison of follitropin alfa/LH versus human menopausal gonadotropin (hMG) has been performed.
Neposredna primerjava med folitropinom alfa/LH in humanim menopavzalnim gonadotropinom (hMG) ni bila izvedena.
• If you are a man: with damaged testicles that cannot be healed.
- Če ste moški: z nepopravljivo poškodbo testisov.
Thromboembolism may occur very rarely, usually associated with severe OHSS (see section 4.4).
Trombembolizem se lahko pojavi zelo redko, običajno v povezavi s hudim OHSS (glejte poglavje 4.4).
Do not throw away any medicines via your sink, toilet or in your household waste.
Zdravila ne smete zavreči v odtok, straniščno školjko ali med gospodinjske odpadke.
4.7 Effects on ability to drive and use machines Follitropin alfa is expected to have no or negligible influence on the ability to drive and use machines.
Pričakuje se, da folitropin alfa nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja strojev.
The prevalence of ectopic pregnancy after ART was reported to be higher than in the general population.
Poročali so o višji prevalenci zunajmaternične nosečnosti po ART kot pri splošni populaciji.
Comparison with historical data suggests that the ovulation rate obtained with follitropin alfa/LH is similar to that obtained with hMG.
Primerjava z dosedanjimi podatki nakazuje, da je delež ovulacij, doseženih s folitropinom alfa/LH, podoben tistemu, ki ga dosežemo s hMG.
Still holding the pen upright, push the dosage knob in until the activation bar with the small arrow disappears.
Medtem, ko injekcijski peresnik držite navzgor, potiskajte gumb za nastavitev odmerka navznoter, dokler črta za aktivacijo z majhno puščico ne izgine.
• Bemfola is intended to be given by injection just under the skin (subcutaneously).
• Zdravilo Bemfola se daje v obliki injekcije tik pod kožo (subkutano).
* recombinant human follicle stimulating hormone (r-hFSH) produced in Chinese Hamster Ovary (CHO) cells by recombinant DNA technology.
* rekombinantni humani folikle stimulirajoči hormon (r-hFSH), pridobljen iz celic jajčnika kitajskega hrčka (Chinese Hamster Ovary - CHO) z uporabo tehnologije rekombinantne DNK.
Patients undergoing stimulation of follicular growth, whether as treatment for anovulatory infertility or ART procedures, may experience ovarian enlargement or develop hyperstimulation.
Pri bolnicah v postopku stimulacije folikularne rasti, bodisi kot zdravljenje anovulacijske neplodnosti bodisi v postopkih ART, se lahko povečajo jajčniki ali se razvije hiperstimulacija.
• The maximum daily dose of Bemfola is usually not higher than 225 IU (0.375 mL).
• Največji dnevni odmerek zdravila Bemfola običajno ne presega 225 i.e. (0,375 ml).
Impaired fertility has been reported in rats exposed to pharmacological doses of follitropin alfa (≥ 40 IU/kg/day) for extended periods, through reduced fecundity.
O okvarah plodnosti so poročali pri podganah, ki so bile daljše obdobje izpostavljene farmakološkim odmerkom folitropina alfa (≥ 40 i.e./kg/dan), in sicer v obliki zmanjšane plodnosti.
• When your eggs are ready, you will be given a single injection of 250 micrograms “recombinant hCG” (r-hCG, an hCG made in a laboratory by a special recombinant DNA technique), or
• Ko so jajčeca pripravljena, boste prejeli eno injekcijo z 250 mikrogrami „rekombinantnega hCG“ (r-hCG, v laboratoriju izdelan hCG s posebno tehnologijo rekombinantne DNK), ali
Treatment is continued until adequate follicular development has been achieved (as assessed by monitoring of serum estrogen concentrations and/or ultrasound examination), with the dose adjusted according to the patient's response, to usually not higher than 450 IU daily.
Zdravljenje se nadaljuje, dokler ni dosežen zadosten folikularni razvoj (kar se oceni s spremljanjem serumske koncentracije estrogena in/ali ultrazvočnim pregledom), tako da se odmerek prilagaja odzivu bolnice in običajno ni večji od 450 i.e. na dan. Na splošno je zadosten folikularni razvoj v povprečju dosežen do desetega dneva zdravljenja (razpon 5 do
In clinical trials, patients with severe FSH and LH deficiency were defined by an endogenous serum LH level < 1.2 IU/L as measured in a central laboratory.
V kliničnih preskušanjih so določili bolnice s hudim pomanjkanjem FSH in LH na podlagi serumske ravni endogenega LH < 1,2 i.e./l, izmerjene v centralnem laboratoriju.
For example, after two weeks of GnRH agonist treatment, 150 to 225 IU Bemfola is administered for 7 days.
Na primer, po dveh tednih zdravljenja z agonistom GnRH se sedem dni daje 150 do 225 i.e. zdravila Bemfola.
Treatment in men Immune system disorders Very rare:
Bolezni imunskega sistema Zelo redki:
For instructions on the administration with the pre-filled pen, see section 6.6 and the package leaflet.
Za navodilo o dajanju zdravila z napolnjenim injekcijskim peresnikom glejte poglavje 6.6 in navodilo za uporabo.
Pregnancy loss
Izguba nosečnosti
• together with another medicine called “human chorionic gonadotropin” (hCG) to help produce sperm in men that are infertile due to a low level of certain hormones.
• skupaj z zdravilom, ki se imenuje „humani horionski gonadotropin“ (hCG) in pomaga pri tvorsperme pri tistih moških, ki so neplodni zaradi nizke ravni nekaterih hormonov.
Bemfola treatment seldom causes severe OHSS unless the medicine that is used for final follicular maturation (containing human chorionic gonadotropin, hCG) is administered.
Zdravljenje z zdravilom Bemfola redko povzroči hud OHSS, razen če se daje zdravilo, ki se uporablja za spodbuditev končnega folikularnega zorenja (ki vsebuje humani horionski gonadotropin - hCG).
When undergoing assisted reproductive technology the risk of having a multiple pregnancy is related to your age, the quality and the number of fertilised eggs or embryos placed inside you.
Pri uporabi postopkov asistirane reprodukcije je tveganje za večplodno nosečnost povezano z vašo starostjo in kakovostjo ter številom oplojenih prenesenih jajčec ali embrijev.
Thromboembolism may occur very rarely (see section 4.4).
Trombembolizem se lahko pojavi zelo redko (glejte poglavje 4.4).
Mild or moderate OHSS (including associated symptomatology)
blag do zmeren OHSS (vključno s povezanimi simptomi)
In adult men, Bemfola is used:
Pri odraslih moških se zdravilo Bemfola uporablja:
Serious side effects in men and women
Resni neželeni učinki pri moških in ženskah
Before opening and within its shelf life, the medicinal product may be removed from the refrigerator, and without being refrigerated again, may be stored for up to 3 months at or below 25°C.
Pred odprtjem in v času roka uporabnosti se lahko zdravilo vzame iz hladilnika in se shranjuje zunaj njega do tri mesece pri temperaturi do 25 °C.
In women whose endogenous gonadotropin secretion is suppressed, follitropin alfa has nevertheless been shown to effectively stimulate follicular development and steroidogenesis, despite unmeasurable LH levels.
Pri ženskah z zavrtim izločanjem endogenega gonadotropina se je izkazalo, da folitropin alfa učinkovito spodbuja razvoj foliklov in steroidogenezo, kljub nemerljivim ravnem LH.
Other side effects in men
Drugi neželeni učinki pri moških
Exacerbation or aggravation of asthma Skin and subcutaneous tissue disorders Common:
ponovni izbruhi ali poslabšanje astme Bolezni kože in podkožja Pogosti:
Do not throw any medicines away via wastewater or household waste.
Zdravila ne smete odvreči v odpadne vode ali med gospodinjske odpadke.
The following symptomatology may be observed in severe cases of OHSS: abdominal pain, abdominal distension, severe ovarian enlargement, weight gain, dyspnoea, oliguria and gastrointestinal symptoms including nausea, vomiting and diarrhoea.
V hudih primerih OHSS lahko opazimo naslednje znake: bolečine v trebuhu, povečanje trebuha, hudo povečanje jajčnikov, pridobivanje telesne mase, dispneo, oligurijo in gastrointestinalne znake, vključno s slabostjo, bruhanjem in drisko.
• Follitropin alfa in association with a luteinising hormone (LH) preparation is recommended for the stimulation of follicular development in women with severe LH and FSH deficiency.
• Folitropin alfa se priporoča skupaj z luteinizirajočim hormonom (LH) za spodbujanje razvoja foliklov pri ženskah s hudim pomanjkanjem LH in FSH.
If an excessive response is obtained, treatment should be stopped and hCG withheld.
Če pride do pretiranega odziva, se mora zdravljenje prekiniti in opustiti dajanje hCG.
If you forget to use Bemfola, do not take a double dose to make up for a forgotten dose.
Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
Then Bemfola is started approximately two weeks after start of agonist treatment.
Nato se približno dva tedna po začetku zdravljenja z agonistom začne zdravljenje z zdravilom Bemfola.
• The usual dose of Bemfola is 150 IU (0.25 mL) together with hCG.
• Običajni odmerek zdravila Bemfola je 150 i.e. (0,25 ml) skupaj s hCG.
Very rarely, severe OHSS may be complicated by ovarian torsion or thromboembolic events such as pulmonary embolism, ischaemic stroke or myocardial infarction.
Pri hudem OHSS je lahko zelo redek zaplet tudi torzija jajčnikov ali trombembolični dogodki, kot so pljučni embolizem, ishemični cerebrovaskularni insult ali miokardni infarkt.
Women with a history of tubal disease are at risk of ectopic pregnancy, regardless of whether the pregnancy is obtained by spontaneous conception or with fertility treatments.
Pri ženskah z boleznijo jajcevodov v anamnezi obstaja tveganje zunajmaternične nosečnosti ne glede na to, ali pride do zanositve spontano ali z zdravljenjem neplodnosti.
Number of oocytes retrieved
Število pridobljenih oocitov
• to help release an egg from the ovary (ovulation) in women that cannot ovulate and that did not respond to treatment with a medicine called “clomiphene citrate”.
• za pomoč pri sproščanju jajčeca iz jajčnika (ovulaciji) pri tistih ženskah, ki nimajo ovulacije in se ne odzivajo na zdravljenje z zdravilom, ki se imenuje „klomifen citrat“;
Solution for injection 1 pre-filled pen 1 injection needle 1 alcohol swab
raztopina za injiciranje 1 napolnjen injekcijski peresnik 1 injekcijska igla 1 alkoholni zloženec
Treatment should be tailored to the individual patient's response as assessed by measuring follicle size by ultrasound and estrogen response.
Zdravljenje mora biti prilagojeno odzivu posamezne bolnice, ki se oceni z merjenjem velikosti folikla z ultrazvokom in estrogenskim odzivom.
Concomitant use of follitropin alfa with other medicinal products used to stimulate ovulation (e.g. hCG, clomiphene citrate) may potentiate the follicular response, whereas concurrent use of a GnRH agonist or antagonist to induce pituitary desensitisation may increase the dose of follitropin alfa needed to elicit an adequate ovarian response.
Sočasna uporaba folitropina alfa z drugimi zdravili, ki se uporabljajo za stimulacijo ovulacije (npr. hCG, klomifen citrat) lahko potencira folikularani odziv, medtem ko lahko sočasna uporaba agonista ali antagonista GnRH za sprožitev desenzitizacije hipofize poveča odmerek folitropina alfa, ki je potreben za dosego ustreznega odziva jajčnikov.
• If you use Bemfola at the same time as a “gonadotropin-releasing hormone” (GnRH) agonist or antagonist (these medicines reduce your sex hormone levels and stop you ovulating) you may need a higher dose of Bemfola to produce follicles.
• Če uporabljate zdravilo Bemfola z agonisti ali antagonisti „gonadotropin sproščujočega hormona“ (GnRH) (ta zdravila zmanjšajo ravni spolnih hormonov in prekinejo ovulacijo), boste morda potrebovali večji odmerek zdravila Bemfola za tvorbo foliklov.
Injecting the dose
Injiciranje odmerka
Do not push the dosage knob in any further, at this point.
Na tej točki gumba za nastavitev odmerka ne potiskajte več navznoter.
The dose is then adjusted according to your ovarian response.
Odmerek se nato prilagodi glede na odziv vaših jajčnikov.
Therefore, if signs of ovarian hyperstimulation occur such as a serum estradiol level > 5,500 pg/mL or > 20,200 pmol/L and/or ≥ 40 follicles in total, it is recommended that hCG be withheld and the patient be advised to refrain from coitus or to use barrier contraceptive methods for at least 4 days.
Zato je v primeru pojava znakov hiperstimulacije jajčnikov, kot so ravni estradiola v serumu > 5.500 pg/ml ali > 20.200 pmol/l in/ali skupno ≥ 40 foliklov, priporočljivo, da se opusti dajanje hCG in se bolnici svetuje, da se najmanj štiri dni vzdrži spolnih odnosov ali uporablja mehanska kontracepcijska sredstva.
Follitropin alfa must not be used when an effective response cannot be obtained, such as in case of:
Folitropina alfa ne smete uporabljati, kadar ni mogoče doseči učinkovitega odziva, kot so npr.:
• Sacs of fluid within the ovaries (ovarian cysts)
• vrečke s tekočino znotraj jajčnikov (ciste jajčnikov);
Total dose of FSH required (number of FSH 75 IU ampoules) 27.6 ± 10.2 40.7 ± 13.6 Need to increase the dose (%)
Število dni, potrebnih za stimulacijo s FSH Skupni odmerek potrebnega FSH (število ampul FSH 75 i.e.) 27,6 ± 10,2
• Local reactions at the injection site, such as pain, redness, bruising, swelling and/or irritation
• lokalne reakcije na mestu injiciranja, kot so bolečina, pordelost, modrice, oteklina in/ali draženje.
The dose is then adjusted according to the ovarian response.
Nato se odmerek prilagodi glede na odziv jajčnikov.
• fibroid tumours of the uterus incompatible with pregnancy;
• fibroidni tumorji maternice, ki niso združljivi z nosečnostjo;
In particular, patients should be evaluated for hypothyroidism, adrenocortical deficiency, hyperprolactinemia and should be treated accordingly.
adrenokortikalno insuficienco in hiperprolaktinemijo ter jih ustrezno zdraviti.
If no liquid splashes out, the pen should not be used.
Če se tekočina iz igle ne iztisne, injekcijskega peresnika ne smete uporabiti.
Reproductive system neoplasms
Novotvorbe reprodukcijskega sistema
Do not push the dosage knob in while attaching the needle.
Ne pritiskajte gumba za nastavitev odmerka, medtem ko nameščate iglo.
There may be a degree of inter-patient variability in response to FSH administration, with a poor response to FSH in some patients and exaggerated response in others.
Razpon odziva na zdravljenje s FSH se lahko med bolniki razlikuje, pri nekaterih bolnikih je odziv na FSH zelo majhen in pri drugih pretiran.
Thromboembolism, (both in association with and separate from OHSS.
trombembolizem, (tako v povezavi z in ločeno od OHSS)
PARTICULARS TO APPEAR ON THE OUTER PACKAGING BOX OF 1, 5 OR 10 PRE-FILLED PENS
PODATKI NA ZUNANJI OVOJNINI ŠKATLA Z 1, 5 ALI 10 NAPOLNJENIH INJEKCIJSKIH PERESNIKOV
Clinical evaluation may reveal hypovolaemia, haemoconcentration, electrolyte imbalances, ascites, haemoperitoneum, pleural effusions, hydrothorax, or acute pulmonary distress.
hemokoncentracijo, elektrolitsko neravnovesje, ascites, hemoperitonej, plevralni izliv, hidrotoraks ali akutno respiratorno stisko.
Given in high doses (≥ 5 IU/kg/day) follitropin alfa caused a decrease in the number of viable foetuses without being teratogenic, and dystocia similar to that observed with urinary menopausal gonadotropin (hMG).
V visokih odmerkih (≥ 5 i.e./kg/dan) je folitropin alfa povzročil zmanjšanje števila živih zarodkov brez teratogenega učinka in distocijo, podobno tisti, ki je bila opažena pri urinarnem menopavznem gonadotropinu (hMG).
The solution should not be administered if it contains particles or is not clear.
Raztopine ne smete uporabiti, če vsebuje delce ali ni bistra.
Independent risk factors for developing OHSS include polycystic ovarian syndrome, high absolute or rapidly rising serum estradiol levels (e.g. > 900 pg/mL or > 3,300 pmol/L in anovulation; > 3,000 pg/mL or > 11,000 pmol/L in ART) and large number of developing ovarian follicles (e.g. > 3 follicles of ≥ 14 mm in diameter in anovulation; ≥ 20 follicles of ≥ 12 mm in diameter in ART).
Neodvisni dejavniki tveganja za razvoj OHSS vključujejo sindrom policističnih jajčnikov, visoke absolutne ali hitro naraščajoče ravni estradiola v serumu (npr. > 900 pg/ml ali > 3.300 pmol/l v anovulaciji; > 3.000 pg/ml ali > 11.000 pmol/l v ART) in veliko število razvijajočih se ovarijskih foliklov (npr. > 3 folikli s premerom ≥ 14 mm v anovulaciji; ≥ 20 foliklov premera ≥ 12 mm v ART).
• Breast development, acne or weight gain.
• razvoj prsi, akne ali pridobivanje telesne mase.
In men deficient in FSH, follitropin alfa administered concomitantly with hCG for at least 4 months induces spermatogenesis.
Pri moških s pomanjkanjem FSH sproži vsaj 4-mesečno dajanje folitropina alfa skupaj s hCG-jem spermatogenezo.
How to use Bemfola
Kako uporabljati zdravilo Bemfola