natgillin/translations-raw huggingface dataset:
However, plasmaferesis can be recommended (high plasma protein-binding, relatively small volume of distribution).
Priporočljiva pa je lahko plazmafereza (visoka vezavnost plazemskih beljakovin, relativno majhen volumen porazdelitve).
Furthermore, a deterioration of heart failure can occur.
Poleg tega lahko pride do poslabšanja srčnega popuščanja.
In addition, in some cases, the use of nifedipine in order to treat pregnant hypertensive women is necessary.
Poleg tega je v nekaterih primerih uporaba nifedipina pri zdravljenju nosečih hipertenzivnih ženskah potrebna.
In individual cases of concomitant use, neuromuscular block has been observed.
V posameznih primerih sočasne uporabe so opazili nevromuskularni blok.
For the treatment of all grades of hypertension.
Za zdravljenje vseh stopenj hipertenzije.
- if your blood pressure is continuing to rise despite treatment (malignant hypertension).
- Če se vaš krvni tlak kljub zdravljenju še naprej zvišuje (maligna hipertenzija).
This should be considered during treatment of hypertension.
Ta učinek je treba upoštevati pri zdravljenju hipertenzije.
Dosage in case of reduced liver function If your liver function is lower than normal, your doctor can prescribe a lower dosage.
Odmerjanje v primeru motenj delovanja jeter Če je delovanje vaših jeter manjše kot normalno, vam bo zdravnik predpisal nižji odmerek.
A total of 6321 patients (55-80 years) were treated during 3 to 4.8 years with Nifedipine Retard or a standard combination of diuretics (hydrochlorothiazide 25 mg + amiloride 5 mg).
Skupno 6321 bolnikov (55-80 let) je bilo zdravljenih 3 do 4,8 let z zdravilom Nifedipine Retard ali standardno kombinacijo diuretikov (hidroklorotiazid 25 mg + amilorid 5 mg).
The metabolites are pharmacologically inactive and non-toxic.
Presnovki niso farmakološko aktivni in niso toksični.
Nifedipine is rapidly and almost completely absorbed (>90%).
Nifedipin se hitro in skoraj povsem absorbira (> 90 %).
Safety in malignant hypertension is not established.
Varnost uporabe pri maligni hipertenziji ni ugotovljena.
Antihypertensive medicines
Antihipertenzivna zdravila
In conclusion, the warning related to women of childbearing potential proposed by the applicant in section 4.6 Pregnancy and lactation is relevant and sufficient.
Zaradi tega je opozorilo, ki ga za ženske v rodni dobi predlaga vlagatelj v poglavju 4.6 Nosečnost in dojenje, smiselno in zadostno.
For a full list of excipients, see section 6.1.
Za celoten seznam pomožnih snovi glejte 6.1.
The following posology is recommended for adults:
Za odrasle so priporočeni naslednji odmerki:
- in case of in vitro fertilisation (IVF).
- V primeru oploditve in vitro (IVF - »in vitro fertilisation«).
Eventually, unconsciousness can occur.
Pride lahko tudi do nezavesti.
- if you use a stoma.
- Če uporabljate stomo.
You should not chew or break the tablets.
Tablet ne smete prežvečiti ali zdrobiti.
The incidence of heart failure shows a difference between both treatments (0.9% versus 0.3%).
Pri pojavnosti odpovedi srca se je pojavila razlika med zdravljenjema (0,9 % proti 0,3 %).
- if you experience severe chest pains, or if the chest pains worsen.
- Če imate hude bolečine v prsih ali če bolečine v prsih postanejo močnejše.
Thus, the proposed wording in section 4.6. of the SmPC to avoid breastfeeding during treatment when necessary, is sufficient.
Zatorej zadostuje predlagano besedilo v poglavju 4.6 SmPC, da se je treba med zdravljenjem odpovedati dojenju, kadar je potrebno.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Če vam je vaš zdravnik povedal, da imate intoleranco za nekatere sladkorje, obvestite svojega zdravnika preden boste vzeli to zdravilo.
Special care is needed in case of very low blood pressure (severe hypotension with systolic pressure below 90 mmHg).
Posebno previdno je treba obravnavati primere zelo nizkega krvnega tlaka (huda hipotenzija s sistoličnim tlakom pod 90 mm Hg).
For chronic stable angina pectoris (exertion-induced angina):
Za kronično stabilno angino pektoris (angina ob naporu):
- if you suffer from unstable angina pectoris.
- Če imate nestabilno angino pektoris.
- if you have diabetes.
- Če imate sladkorno bolezen.
Intravenous magnesium sulphate
Intravensko dajanje magnezijevega sulfata
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, notably rifampicin, including medicines obtained without a prescription.
Obvestite svojega zdravnika ali farmacevta, če jemljete ali ste pred kratkim jemali katerokoli zdravilo, tudi če ste ga dobili brez recepta.
Nifedipine is contraindicated during pregnancy and not recommended in women who intend to get pregnant in the near future.
Nifedipin je kontraindiciran med nosečnostjo in ni priporočljiv za ženske, ki nameravajo zanositi v bližnji prihodnosti.
Carton box with blister strips made of PVC/PVDC and aluminium foil.
Kartonska škatla s pretisnimi omoti iz PVC/PVDC in aluminijaste folije.
fever in the first few days after initiating therapy.
povišana telesna temperatura v prvih nekaj dneh po začetku zdravljenja
By doing so, the blood flow in the heart and limbs is improved, lowering blood pressure and preventing chest pain (angina pectoris).
S tem izboljša pretok krvi v srce in okončine, zniža krvni tlak in preprečuje bolečine v prsih (angina pektoris).
Whenever this is the case, the treating physician should be notified immediately, and treatment with nifedipine should be ceased.
Kadar se to zgodi, je treba nemudoma obvestiti zdravnika, ki vodi zdravljenje, in prekiniti zdravljenje z nifedipinom.
Therefore, monitoring of quinidine plasma levels is recommended.
Zato je priporočljivo spremljanje plazemskih koncentracij kinidina.
This randomised, double blind, prospective study was carried out on an average population of patients with hypertension that, besides a blood pressure of 150/95 mm Hg or higher or a systolic blood pressure of >160 mm Hg, presented with at least one other cardiovascular risk factor.
V to randomizirano, dvojno slepo, prospektivno študijo so vključili povprečno populacijo bolnikov s hipertenzijo, ki so imeli najmanj en dejavnik tveganja srčno-žilne bolezni in bodisi krvni tlak 150/95 mm Hg ali več bodisi sistolični krvni tlak >160 mmHg.
In case of life-threatening bradycardia, a temporary cardiac pacemaker can be used.
V primeru življenjsko ogrožajoče bradikardije lahko uporabimo začasni srčni spodbujevalnik.
In addition, β-sympathomimetics may be given, e.g. 0.2 mg isoprenalin slowly i.v.
Poleg naštetega lahko damo β-simpatomimetike, npr. 0,2 mg izoprenalina počasi i.v.
Caution should be exercised in patients with hypotension, as there is a risk of further reduction in blood pressure.
Previdnost je potrebna pri bolnikih s hipotenzijo, saj obstaja nevarnost dodatnega znižanja krvnega tlaka.
MARKETING AUTHORISATION HOLDER Pharmamatch BV
IMETNIK DOVOLJENJA ZA PROMET Pharmamatch BV
Pregnancy and breast-feeding Ask your doctor or pharmacist for advice before taking any medicine.
Nosečnost in dojenje Posvetujte se z zdravnikom ali farmacevtom, preden vzamete katerokoli zdravilo.
Thus, contraindicating the use of nifedipine in women of childbearing potential, which amounts to contraindicating it from the beginning of the first trimester of pregnancy, should result in a loss of chance in this target population since nifedipine cannot be considered as a teratogenic product.
Zaradi tega bi kontraindiciranje zdravila nifedipine pri ženskah v rodni dobi, kar ustreza kontraindiciranju tega zdravila od začetka prvega trimesečja nosečnosti, imelo za posledico zmanjšanje možnosti pri tej ciljni populaciji, saj zdravilo nifedipin ne more biti obravnavano kot teratogeno.
nocturnal enuresis, acute, reversible deterioration in renal function in patients with chronic renal insufficiency.
nočna enureza, akutno, reverzibilno poslabšanje ledvične funkcije pri bolnikih s kronično ledvično insuficienco
Distribution Both nifedipine and its metabolites are mainly bound to plasma protein (92-98%).
Porazdelitev Nifedipin in njegovi presnovki se v glavnem vežejo na plazemske beljakovine (92-98 %).
It is not known if a pharmacological effect in the infant can occur because of this; however, it is recommended to cease breast feeding as a precautionary measure.
Ni znano, ali zaradi tega pride do farmakološkega učinka na dojenčka, zato je priporočljivo iz previdnosti prekiniti dojenje.
Medicines that are known to either inhibit or induce this enzyme can therefore alter the absorption (after oral administration) or elimination of nifedipine.
Zdravila, za katere je znano bodisi zaviranje bodisi induciranje tega encima, lahko torej spremenijo absorpcijo (pri peroralnem jemanju) oz. izločanje nifedipina.
SPECIAL STORAGE CONDITIONS Store in the original packaging.
POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte v originalni ovojnini.
After regular intake of grapefruit juice, this effect may last for at least three days after the last ingestion of grapefruit juice.
Če bolnik redno uživa grenivkin sok, lahko ta učinek traja vsaj še tri dni po zadnjem zaužitju grenivkinega soka.
Moreover, as is the case for all oral administrations, the active substance undergoes a first pass effect.
Kot pri vseh peroralno uporabljenih zdravilih je zdravilna učinkovina podvržena učinku prvega prehoda.
Moreover, the number of reported symptomatic adverse events was higher in the group treated with nifedipine than in the control group.
Poleg naštetega je bilo število poročanih simptomatskih neželenih učinkov večje v skupini, ki je bila zdravljena z nifedipinom v primerjavi s kontrolno skupino.
The safety of nifedipine during pregnancy has not been established.
Varnost nifedipina med nosečnostjo ni ugotovljena.
Elimination of the product and the restoration of stable cardiovascular conditions may be needed.
Morda bo potrebno odstranjevanje zdravila in obnovitev stabilnega srčno-žilnega stanja.
OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF NIFEDIPINE PHARMAMATCH RETARD 30/60 mg and associated names (See Annex I)
SPLOŠNI POVZETEK ZNANSTVENEGA VREDNOTENJA ZDRAVILA NIFEDIPINE PHARMAMATCH RETARD 30/60 mg in povezana imena (glejte Dodatek I)
oesophageal reflux in patients with systemic sclerosis, allergic hepatitis, increased portal pressure in patients with alcoholic cirrhosis, transient increase in liver enzymes.
ezofagealni refluks pri bolnikih s sistemsko sklerozo, alergijski hepatitis, zvišan portalni tlak pri bolnikih z alkoholno cirozo, prehodno zvišanje ravni jetrnih encimov
Nifedipine has a short half-life of approximately 2 - 4 hours.
Razpolovna doba nifedipina je kratka in znaša od 2 do 4 ure.
Dosage in case of reduced kidney function
Odmerjanje v primeru motenj delovanja ledvic
Haemodialysis is not useful, since nifedipine cannot be dialysed.
Hemodializa ni uporabna, saj se nifedipin ne dializira.
In patients with hepatic impairment, the elimination half-life is distinctly prolonged and the total clearance is reduced.
Pri bolnikih z motnjami delovanja jeter je razpolovna doba izločanja izrazito podaljšana, skupni očistek je zmanjšan.
Nifedipine is contraindicated during pregnancy (See section 4.3).
Nifedipin je kontraindiciran med nosečnostjo (glejte poglavje 4.3).
PHARMACEUTICAL FORM AND CONTENTS 28 prolonged-release tablets.
FARMACEVTSKA OBLIKA IN VSEBINA 28 tablet s podaljšanim sproščanjem.
Round, biconvex tablets with a pale red colour.
Okrogle, bikonveksne tablete bledo rdeče barve.
The results show that Nifedipine Retard demonstrates both a comparable antihypertensive effect and a comparable effect on the above-mentioned composite end-point.
Rezultati so pokazali, da zdravilo Nifedipine Retard kaže primerljiv antihipertenzivni učinek in primerljiv učinek na zgoraj omenjeni sestavljeni opazovani dogodek.
Hypotension as a result of cardiogenic shock and arterial vasodilatation should be treated with calcium (10-20 ml of calcium gluconate 10% slowly i.v., to be repeated if necessary).
Hipotenzijo kot posledico kardiogenega šoka in arterijske vazodilatacije zdravimo s kalcijem (1020 ml 10 % kalcijevega glukonata, počasi, i.v., po potrebi ponoviti).
If an insufficient increase in blood pressure is achieved with calcium and isoprenalin, vasoconstricting sympathomimetics such as dopamine or noradrenalin should be administered.
Če s kalcijem in izoprenalinom ne dosežemo zadostnega zvišanja krvnega tlaka, moramo uporabiti vazokonstrikcijske simpatomimetike, kot je dopamin ali noradrenalin.
There are no adequate data from the use of nifedipine in pregnant women.
Ni zadostnih podatkov o uporabi nifedipina pri nosečnicah.
Especially for prolonged-release products (Nifedipine Pharmamatch retard) elimination must be as complete as possible, including the small intestine, to prevent the otherwise inevitable subsequent absorption of the active substance.
Zlasti zdravila s podaljšanim sproščanjem (Nifedipine Pharmamatch retard) je treba odstraniti čimbolj temeljito, kar vključuje tanko črevo, da se prepreči sicer neizogibno naknadno absorpcijo zdravilne učinkovine.
Nifedipine should not be used by women who intend to get pregnant in the near future (see section 4.4).
Nifedipina ne smejo jemati ženske, ki nameravajo zanositi v bližnji prihodnosti (glejte poglavje 4.4).
gynaecomastia in men over 50 years; reversible at discontinuation of treatment.
ginekomastija pri moških, starejših od 50 let, ki je reverzibilna po prekinitvi zdravljenja
The duration of action of nifedipine can be shortened.
V tem primeru se lahko skrajša trajanje delovanja nifedipina.
Nifedipine should be used with caution in patients with (threatening) ischemia of fingers and/or toes, because this can be worsened due to decreased tissue perfusion as a result of a lower perfusion pressure.
Nifedipin je treba uporabljati previdno pri bolnikih z (grozečo) ishemijo prstov na roki in/ali prstov na nogi, saj se lahko to stanje poslabša zaradi zmanjšane perfuzije skozi tkiva, ki je posledica nižjega perfuzijskega tlaka.
Cardiac effects may include heart block, AV dissociation and asystole, and cardiogenic shock with pulmonary oedema.
- Učinki na srce lahko vključujejo srčni blok, atrioventrikularno (AV) disociacijo in asistolo ter kardiogeni šok s pljučnim edemom.
Therefore, the tablets are appropriate for once-daily administration.
Zato so tablete primerne za jemanje enkrat dnevno.
It takes some time (lagtime of 2-4 hours) before the active substance escapes from Nifedipine Pharmamatch retard tablets.
Nekaj časa traja (zakasnitev 2-4 ure) preden zdravilna učinkovina preide iz tablet zdravila Nifedipine Pharmamatch retard.
After release and absorption of the final dose the plasma concentration decreases, showing the same half-life values that were observed with oral formulations.
Po sprostitvi in absorpciji zadnjega odmerka se plazemska koncentracija znižuje in kaže vrednosti razpolovne dobe, značilne za peroralne farmacevtske oblike.
In the event of overdose it is recommended to lay down the patient with elevated legs, for instance by using some pillows.
V primeru prekomernega odmerjanja je priporočljivo, da bolnika položimo v ležeč položaj in dvignemo njegove noge (npr. z blazinami).
As a precaution, it is recommended to stop breast-feeding.
Iz previdnosti je priporočljivo, da prenehate dojiti.
Co-administration of nifedipine with rifampicin is therefore contra-indicated.
Hkratna uporaba nifedipina in rifampicina je zato kontraindicirana.
- The scope of the referral was to agree whether nifedipine should be contraindicated for women capable of childbearing or for nursing women and to amend the Summary of Products Characteristics in view of the available safety data
- Namen napotitve je bil doseči soglasje o tem, ali naj bo uporaba nifedipina kontraindicirana pri ženskah v rodni dobi ali pri doječih materah ter ali naj se besedilo Povzetka glavnih značilnosti zdravila ustrezno spremeni glede na razpoložljive podatke o varnosti
Nifedipine Pharmamatch retard tablets must not be prescribed for these patients.
Pharmamatch retard tablete se ne sme predpisati tem bolnikom.
Nifedipine is a calcium antagonist and has a spasmolytic effect on the vascular wall of mainly coronary arteries.
Nifedipin je antagonist kalcijevih kanalčkov in ima spazmolitičen učinek na žilne stene, zlasti stene koronarnih arterij.
Separate analysis of the individual end-points show little differences in incidence between the groups treated with nifedipine or diuretics of stroke (2.0% versus 2.3%), MI (2.9% versus 2.7%) and death caused by any other cardiovascular disease (0.4% versus 0.4%).
Ločena analiza posameznih opazovanih dogodkov med skupino bolnikov, ki so prejemali nifedipin, in skupino bolnikov, ki so prejemali diuretike, je pokazala majhne razlike v pojavnosti infarkta (2,0 % proti 2,3 %), miokardnega infarkta (2,9 % proti 2,7 %) in smrti zaradi katerekoli srčno-žilne bolezni (0,4 % proti 0,4 %).
Cardiogenic shock, clinically significant aortic stenosis, unstable angina pectoris, or during or within one month of a myocardial infarction.
- Kardiogeni šok, klinično pomembna aortna stenoza, nestabilna angina pektoris ali v prvem mesecu po miokardnem infarktu.
There are situations when other treatment alternatives are not suitable or where calcium antagonists are appropriate to include in a combination of different drugs after careful benefit/risk evaluation.
Obstajajo primeri, v katerih druge vrste zdravljenja niso ustrezne, ali kjer je po skrbnem vrednotenju razmerja med koristmi in tveganji antagoniste kalcijevih kanalčkov primerno vključiti v kombinacijo z drugimi zdravili.
Nifedipine Pharmamatch retard is formulated in such way that it releases the active substance in the intestine with a practically constant rate over a 16 to 18 hour time period.
Zdravilo Nifedipine Pharmamatch retard je oblikovano tako, da sprošča svojo zdravilno učinkovino v črevesju s praktično stalno hitrostjo v časovnem obdobju 16 do 18 ur.
The use of rifampicin.
- Jemanje rifampicina.
Do not take Nifedipine Pharmamatch retard - if you are allergic (hypersensitive) to nifedipine or any of the other ingredients of Nifedipine
Ne jemljite zdravila Nifedipine Pharmamatch retard - Če ste alergični na (preobčutljivi za) nifedipin ali katerokoli sestavino zdravila Nifedipine
If you stop taking Nifedipine Pharmamatch retard If you suddenly stop using this medicine, the symptoms that you had before you started taking this medicine can come back.
Če ste prenehali jemati zdravilo Nifedipine Pharmamatch retard Če nenadoma prenehate jemati zdravilo, se lahko znova pojavijo simptomi, ki ste jih imeli pred jemanjem tega zdravila.
If quinidine is added to an existing nifedipine therapy, blood pressure should be carefully monitored.
Če obstoječemu zdravljenju z nifedipinom dodamo kinidin, moramo skrbno spremljati krvni tlak.
ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORMS, STRENGTHS OF THE MEDICINAL PRODUCTS, ROUTES OF ADMINISTRATION, APPLICANTS, MARKETING AUTHORISATION HOLDERS IN THE MEMBER STATES
DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, NAČINOV UPORABE ZDRAVILA, VLAGATELJEV, IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
3930 EB Woudenberg The Netherlands
3930 EB Woudenberg Nizozemska
Co-administration of grapefruit juice reduces the first pass effect on nifedipine (see section 4.5).
Sočasen vnos grenivkinega soka zmanjša učinek prvega prehoda za nifedipin (glejte poglavje 4.5).
When used concomitantly, nifedipine does not affect the pharmacokinetics of candesartancilexetil, cerivastatin or irbesartan.
Pri sočasni uporabi nifedipin ne vpliva na farmakokinetiko kandesartancileksetila, cerivastatina ali irbesartana.
As a precaution, the patient should be examined for symptoms of digoxin overdose and, if necessary, a reduction of the glycoside-dosage should be considered, taking into account the plasma concentration of digoxin.
Kot previdnostni ukrep je treba bolnika preiskati glede simptomov prekomernega odmerjanja digoksina in po potrebi znižati odmerek glikozida, pri čemer je treba upoštevati plazemske koncentracije digoksina.
When nifedipine is added to therapy with a diuretic, a temporary induced saluretic effect can occur, and a pre-existing hypokalaemia can be induced.
Ko nifedipin dodamo zdravljenju z diuretikom, lahko pride do začasno induciranega saluretičnega učinka in indukcije že obstoječe hipokaliemije.
Use in children Nifedipine is not recommended for use in children
Uporaba pri otrocih Nifedipina ni priporočljivo uporabljati pri otrocih.
Nifedipine is metabolised via the cytochrome P450 3A4 system (CYP3A4), which is present in the intestinal mucosa and the liver.
Nifedipin se presnavlja prek sistema citokroma P450 3A4 (CYP3A4), ki se nahaja v intestinalni sluznici in v jetrih.
If you take too much nifedipine a low blood pressure (hypertension) can occur, which can be recognised from symptoms like dizziness, nausea, vomiting, drowsiness, confusion, lethargy, flushing, a lack of oxygen (hypoxia), headache or red spots on the face.
Če ste vzeli preveč nifedipina, lahko pride do nizkega krvnega tlaka (hipotenzije), ki se kaže s simptomi, kot so omotica, slabost, bruhanje, zaspanost, zmedenost, letargija, rdečica, pomanjkanje kisika (hipoksija), glavobol in rdeče pike na obrazu.
In conclusion, the benefit/risk ratio favours the opinion that the use of nifedipine should not be contraindicated for women capable of childbearing or for nursing women.
Razmerje med koristmi in tveganji je v prid mnenju, da uporaba nifedipina ni kontraindicirana pri ženskah v rodni dobi ali za doječe matere.
Blood pressure, ECG, central arterial pressure, pulmonary wedge pressure, urea and electrolytes should be monitored.
Spremljati moramo krvni tlak, EKG, centralni arterijski tlak, pljučni zagozditveni tlak, sečnino in elektrolite.
Nifedipine can aggravate an existing decompensatio cordis in: patients with an obstruction of the out-flow tract, in which an increase of the gradient of the decompensation sometimes occurs (e.g. aorta stenosis) (See section 4.3); patients with a right-sided decompensatio cordis, in which in some cases a decrease of cardiac output, accompanied with increased fluid retention, occurs.
Nifedipin lahko poslabša obstoječo dekompenzacijo srca pri: - bolnikih z obstrukcijo iztočne poti, pri kateri včasih prihaja do zvišanja gradienta dekompenzacije (npr. aortna stenoza) (glejte poglavje 4.3); - bolnikih z desnostransko dekompenzacijo srca, pri kateri včasih prihaja do zmanjšanja minutnega srčnega iztisa, kar spremlja povečano zastajanje tekočin.
Nifedipine is part of a group of medicines that relax and expand blood vessels (calcium antagonists).
Nifedipin spada v skupino zdravil, ki sproščajo in raztegujejo žile (antagonisti kalcijevih kanalčkov).
Hypersensitivity to nifedipine or other dihydropyridines, or to any of the excipients.
- Preobčutljivost za nifedipin ali druge dihidropiridine ali katerokoli pomožno snov.
The number of severe adverse events, as well as the number of reported metabolism-related adverse events such as hypokalaemia, hyponatraemia and hyperuremia, was lower in the group treated with nifedipine.
Število hudih neželenih učinkov in število s presnovo povezanih učinkov, kot so hipokaliemija, hiponatriemija in hiperuremija, je bilo manjše v skupini bolnikov, zdravljenih z nifedipinom.
Published data show that in individual cases the tacrolimus dose can be reduced when co-administered with nifedipine.
Objavljeni podatki kažejo, da se lahko v posameznih primerih odmerek takrolimusa zniža pri sočasnem dajanju z nifedipinom.
Preferably the tablets are administered in the morning with a glass of water (no grapefruit juice; see also section 4.5).
Najbolje je, če bolnik tablete jemlje zjutraj s kozarcem vode (brez grenivkinega soka; glejte tudi poglavje 4.5).
The intake of grapefruit juice during treatment with nifedipine is discouraged (see also section 5.2).
Vnos grenivkinega soka med zdravljenjem z nifedipinom ni priporočljiv (glejte tudi poglavje 5.2).
Bradycardia can be treated symptomatically with atropine or with β-sympathomimetics, like isoprenalin.
Bradikardijo lahko zdravimo simptomatsko z atropinom ali β-simpatomimetiki, kot je izoprenalin.