natgillin/translations-raw huggingface dataset:
If analgesia is insufficient during the first application only, the DUROGESIC patch may be replaced after 48 hours with a patch of the same dose, or the dose may be increased after 72 hours.
Če analgezija med prvo namestitvijo ni zadostna, lahko transdermalni obliž DUROGESIC zamenjate po 48 urah z obližem enake jakosti ali pa odmerek povečate po 72 urah.
As for patients with Grade C liver disease (Child-Pugh Score = 12.5), the results indicate that fentanyl concentration accumulates with each administration, leading these patients to have an approximately 3.72 times larger AUC at steady state.
Kot velja za bolnike z okvaro jeter razreda C (stopnja Child-Pugh = 12,5), rezultati kažejo, da se koncentracije fentanila akumulirajo z vsako aplikacijo, tako da imajo ti bolniki približno 3,72-krat večjo AUC v stanju dinamičnega ravnovesja.
(16.3%), constipation (13.5%), diarrhoea (12.8%), and pruritus (12.8%).
glavobol (16,3 %), zaprtje (13,5 %), driska (12,8 %) in srbenje (12,8 %).
The incidence of respiratory depression increases as the DUROGESIC dose is increased (see section 4.9).
Pojavnost depresije dihanja se povečuje s povečevanjem odmerka zdravila DUROGESIC (glejte poglavje 4.9).
Acute or postoperative pain because there is no opportunity for dose titration during short-term use and because serious or life-threatening hypoventilation could result.
Akutna ali pooperativna bolečina, ker med kratkotrajno uporabo prilagajanje odmerka ni mogoče, kar lahko vodi do resne ali življenjsko nevarne hipoventilacije.
The manifestations of fentanyl overdose are an extension of its pharmacologic actions, the most serious effect being respiratory depression.
Znaki prevelikega odmerjanja fentanila so posledica njegovih njegovih farmakoloških učinkov; najresnejši med njimi je depresija dihanja.
Do not apply the patch on
Obliža ne namestite na
• Do not use the patch if it has been divided, cut or looks damaged
• Obliža ne uporabite, če je razpolovljen, razrezan ali kakor koli drugače poškodovan.
Fentanyl then becomes available to the systemic circulation.
Takrat postane fentanil dostopen sistemskemu krvnemu obtoku.
It also crosses the placenta and is excreted in breast milk.
Prehaja tudi skozi placento in se izloča z materinim mlekom.
Of the 289 subjects enrolled in these 3 studies, 110 initiated DUROGESIC treatment with a dosage of 12 mcg/h.
vključenih preiskovancev, vključenih v te 3 študije, je 110 preiskovancev zdravljenje začelo z zdravilom DUROGESIC v odmerku 12 mikrogramov/h.
DUROGESIC is indicated for management of severe chronic pain that requires continuous long term opioid administration.
Zdravilo DUROGESIC je indicirano za obvladovanje hude kronične bolečine, ki zahteva kontinuirano dolgotrajno zdravljenje z opioidi.
The safety of DUROGESIC was evaluated in 1565 adult and 289 paediatric subjects who participated in 11 clinical studies (1 double-blind, placebo-controlled; 7 open-label, active-controlled; 3 open-label, uncontrolled) used for the management of chronic malignant or non-malignant pain.
Varnost zdravila DUROGESIC so ocenili pri 1.565 odraslih in 289 pediatričnih preiskovancih, ki so sodelovali v 11 kliničnih študijah (1 dvojno slepa, nadzorovana s placebom, 7 odprtih, nadzorovanih z učinkovino, 3 odprte, nenadzorovane) za zdravljenje kronične maligne ali nemaligne bolečine.
In these cases, only DUROGESIC 12 mcg/h dosage should be considered for initial treatment.
V takih primerih se za uvedbo zdravljenja uporablja le jakost zdravila DUROGESIC 12 mikrogramov/h.
Where to apply the patch
Kam namestiti obliž
• Keep the empty sachet to dispose of the used patch later
• Prazno vrečico shranite in jo uporabite kasneje, da zavržete uporabljen obliž.
Fentanyl induced mutagenic effects in mammalian cells in vitro, comparable to other opioid analgesics.
Fentanil je povzročil mutagene učinke na sesalskih celicah in vitro, podobno kot drugi opioidni analgetiki.
Therefore, DUROGESIC should not be used within 14 days after discontinuation of treatment with MAOIs.
Zato se zdravila DUROGESIC ne sme uporabljati še 14 dni po prenehanju zdravljenja z zaviralci MAO.
The extent of the interactions of CYP3A4 inhibitors with long-term transdermal fentanyl administration is not known, but may be greater than with short-term intravenous administration.
Obseg interakcij zaviralcev CYP3A4 z dolgotrajno transdermalno uporabo fentanila ni znan, je pa lahko večji kot pri kratkotrajni intravenski aplikaciji.
Patients at increased risk of opioid abuse may still be appropriately treated with modified-release opioid formulations; however, these patients will require monitoring for signs of misuse, abuse, or addiction.
Bolnike z večjim tveganjem za zlorabo opioidov se lahko še vedno ustrezno zdravi z oblikami opioidov s prirejenim sproščanjem, vendar je treba takšne bolnike skrbno spremljati glede znakov zlorabe, napačne uporabe ali odvisnosti.
• Medicines to treat tuberculosis (such as rifampicin).
• zdravila za zdravljenje tuberkuloze (kot je rifampicin).
• Always apply the patch to the upper back to make it difficult for your child to reach it or take it off.
• Otrokom obliž vedno nalepite na zgornji del hrbta tako, da ga ne more doseči ali odlepiti.
• Feeling anxious or confused
• občutek vznemirjenosti ali zmedenosti
DUROGESIC should not be used during pregnancy unless clearly necessary.
Zdravila DUROGESIC se ne sme uporabljati med nosečnostjo, če ni nujno potrebno.
Your doctor will know which medicines are safe to take with DUROGESIC.
Zdravnik ve, katera zdravila so varna za sočasno uporabo z zdravilom DUROGESIC.
• Remove the other part of the backing and press the whole patch onto the skin with the palm of your hand
• Odstranite drugi del zaščitne plasti obliža in celoten obliž z dlanjo pritisnite na kožo.
Skin temperature elevation may enhance the absorption of transdermally-applied fentanyl (see section 4.4).
Porast temperature v koži lahko zveča absorbcijo transdermalno uporabljenega fentanila (glejte poglavje 4.4).
• Tear or cut open the sachet at the notch, shown by the arrow
• Pretrgajte ali prerežite vrečico pri zarezi, kot kaže puščica.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Če imate kakršna koli vprašanja o uporabi tega zdravila, se posvetujte z zdravnikom ali farmacevtom.
Used patches should be folded so that the adhesive side of the patch adheres to itself and then they should be safely discarded.
Uporabljene obliže je treba najprej prepogniti, tako da se lepilna plast zlepi, in šele nato varno zavreči.
Careful monitoring should be continued until stable drug effects are achieved.
Dokler ne dosežete stabilnega učinka zdravila, je potrebno nadaljnje skrbno spremljanje.
Signs of overdose include trouble breathing or shallow breathing, tiredness, extreme sleepiness, being unable to think clearly, walk or talk normally and feeling faint, dizzy or confused.
Znaki prevelikega odmerjanja so težko ali plitvo dihanje, utrujenost, huda zaspanost, nezmožnost jasnega razmišljanja, normalne hoje ali govora in občutek omedlevice, omotičnosti ali zmedenosti.
• It may take some time for the patch to have its maximum effect.
• Lahko traja nekaj časa, preden začne obliž v celoti delovati.
METHOD AND ROUTE(S) OF ADMINISTRATION Transdermal Use
POSTOPEK IN POT(I) UPORABE ZDRAVILA transdermalna uporaba
The minimum effective fentanyl concentration depends on the pain intensity and the previous use of opioid therapy.
Minimalne učinkovite koncentracije fentanila so odvisne od intenzitete bolečine in predhodne uporabe opioidov.
If you or your partner, or carer, notice any of the following about the person wearing the patch, take the patch off and call a doctor, or go to your nearest hospital, straight away.
Če vi ali vaš partner ali negovalec opazite karkoli od spodaj navedenega, obliž odstranite in nemudoma pokličite zdravnika ali pojdite v najbližjo bolnišnico.
• DUROGESIC patches are for long-term pain.
• Obliži zdravila DUROGESIC se uporabljajo za dolgotrajno bolečino.
• in children above 2 years of age who are already using opioid medication and who need continuous pain treatment.
•pri odraslih, ki potrebujejo neprekinjeno zdravljenje bolečine •pri otrocih, starih več kot 2 leti, ki že prejemajo opioidna zdravila in potrebujejo neprekinjeno zdravljenje bolečine
Based on pooled safety data from these 3 clinical studies in paediatric subjects, the most commonly reported (i.e. ≥10% incidence) adverse reactions were vomiting (33.9%), nausea (23.5%), headache
Na osnovi združenih podatkov o varnosti iz teh 3 kliničnih študij pri pediatričnih preiskovancih, so bili najpogosteje poročani neželeni učinki (pojavnost ≥ 10 %) bruhanje (33,9 %), navzea (23,5 %),
• Make sure your skin is completely dry, clean and cool before you put the patch on
• Poskrbite, da je pred namestitvijo obliža vaša koža popolnoma suha, čista in hladna.
If the clinical situation warrants, a patent airway should be established and maintained, possibly with an oropharyngeal airway or endotracheal tube, and oxygen should be administered and respiration assisted or controlled, as appropriate.
Če klinične okoliščine to zahtevajo, je treba zagotoviti in vzdrževati prehodnost dihalnih poti, lahko z orofaringealnim ali endotrahealnim tubusom; po potrebi dodajati kisik in zagotoviti asistirano ali kontrolirano ventilacijo.
The potential risk for humans is unknown, although fentanyl as an IV anaesthetic has been found to cross the placenta in human pregnancies.
Možno tveganje za ljudi ni znano, čeprav so ugotovili, da fentanil kot intravenski anestetik pri ljudeh med nosečnostjo prehaja skozi placento.
The conversion schedule should not be used to convert from DUROGESIC into other opioids, as overdosing could then occur.
Sheme za preračunavanje se ne sme uporabiti za prehod s transdermalnih obližev DUROGESIC na druge opioide, ker lahko pride do prevelikega odmerjanja.
If the analgesic effect of DUROGESIC is insufficient, supplementary morphine or another short-duration opioid should be administered.
Če analgetični učinek zdravila DUROGESIC ni zadosten, je treba bolniku dodatno dati morfin ali drug kratkodelujoči opioid.
• Itchy skin rash (eczema), allergic reaction or other skin disorders where the patch is placed
• zapora črevesja (ileus) • srbenje kože (ekcem), alergijske reakcije ali druge bolezni kože na mestu, kjer je nameščen obliž
Long term management of severe chronic pain in children from 2 years of age who are receiving opioid therapy.
Dolgoročno zdravljenje hude kronične bolečine pri otrocih, starih 2 leti ali več, ki že prejemajo zdravljenje z opioidi.
Fentanyl may produce bradycardia and should therefore be administered with caution to patients with bradyarrhythmias.
Srčne bolezni Fentanil lahko povzroči bradikardijo, zato ga je treba pri bolnikih z bradiaritmijami uporabljati previdno.
If you use too many patches or the wrong strength patch If you have stuck on too many patches or the wrong strength patch, take the patches off and contact a doctor straight away.
Če ste uporabili preveč obližev ali napačno jakost obliža Če ste prilepili prveč obližev ali ste uporabili napačno jakost obliža, jih odstranite in takoj obvestite zdravnika.
• Some medicines used to treat angina (chest pain) or high blood pressure (such as nicardipine).
• Nekatera zdravila za zdravljenje angine pektoris (bolečina v prsnem košu) ali visokega krvnega tlaka (kot je nikardipin).
Multiplication Factor morphine oral
Pot uporabe multiplikator morfin peroralna
There is a potential for temperature-dependent increases in fentanyl released from the system resulting in possible overdose and death.
Obstaja možnost povečanega sproščanja fentanila iz sistema zaradi zvišane temperature, kar lahko vodi v preveliko odmerjanje in smrt.
• Feeling unusually drowsy, breathing that is more slow or shallow than expected.
• Občutek neobičajne zaspanosti, počasnejše ali bolj plitvo dihanje od običajnega.
Monitoring of the patient for adverse events, which may include hypoventilation, is recommended for at least 48 hours after initiation of DUROGESIC therapy or up-titration of the dose (see section 4.4).
Spremljanje bolnikov glede neželenih učinkov, ki lahko vključujejo hipoventilacijo, je priporočljivo vsaj 48 ur po začetku zdravljenja z zdravilom DUROGESIC ali po zvečanju odmerka (glejte tudi poglavje 4.4).
Even though impairment of renal function is not expected to affect fentanyl elimination to a clinically relevant extent, caution is advised because fentanyl pharmacokinetics has not been evaluated in this patient population (see section 5.2).
Čeprav naj okvara ledvic ne bi vplivala na izločanje fentanila v klinično pomembnem obsegu, je priporočljiva previdnost, ker farmakokinetike fentanila v tej populaciji bolnikov niso ocenjevali (glejte poglavje 5.2).
The dose should be titrated individually until a balance between analgesic efficacy and tolerability is attained.
Odmerek je treba prilagajati individualno, dokler ne dosežemo ravnovesja med analgetično učinkovitostjo in prenašanjem zdravila.
Fentanyl concentrations were measured in more than 250 children aged 2 to 17 years who were applied fentanyl patches in the dose range of 12.5 to 300 mcg/h.
Koncentracije fentanila so merili pri več kot 250 otrocih, starih od 2 do 17 let, katerim so namestili obliže s fentanilom v jakostih od 12,5 do 300 mikrogramov/h.
This effect could either be due to altered maternal care or a direct effect of fentanyl on the pups.
Ta učinek bi lahko bil posledica spremenjene nege mladičev s strani samice ali neposrednega učinka fentanila na mladiče.
Fold the patch in the middle and remove each half of the liner separately.
Obliž po sredini upognemo in odstranimo vsako polovico zaščitne plasti posebej.
If it does not, or if the patch irritates your skin badly, tell your doctor.
Če ne izgine ali če obliž močno razdraži kožo, se posvetujte z zdravnikom.
• Take the patch out and use straight away
• Obliž vzemite iz vrečice in ga takoj uporabite.
The influence of renal impairment on the pharmacokinetics of fentanyl is expected to be limited because urinary excretion of unchanged fentanyl is less than 10% and there are no known active metabolites eliminated by the kidney.
Okvara ledvic Vpliv okvare ledvic na farmakokinetiko fentanila je majhen, ker se nespremenjen fentanil izloča z urinom v manj kot 10%, aktivni presnovki, ki bi se izločali preko ledvic, pa niso znani.
• Gently tear or cut off the edge of the sachet completely (if you use scissors, cut close to the sealed edge of the sachet to avoid damaging the patch)
• Previdno po celotni dolžini odtrgajte ali odrežite rob blazinice (blizu zavarjenega roba blazinice, da ne poškodujete obliža).
Application site hypersensitivity, Drug withdrawal syndrome, Pyrexia*
preobčutljivost na mestu namestitve, sindrom odtegnitve zdravila, pireksija*
Non-epileptic (myo)clonic reactions can occur.
Lahko se pojavijo (mio)klonične reakcije, ki niso posledica epilepsije.
The extent of interaction with strong CYP3A4 inhibitors is expected to be greater than with weak or moderate CYP3A4 inhibitors.
Pričakovati je večji obseg interakcij z močnimi zaviralci CYP3A4 kot s šibkimi ali zmernimi zaviralci CYP3A4.
By the end of the second 72-hour application, a steady-state serum concentration is reached and is maintained during subsequent applications of a patch of the same size.
Do konca druge 72 urne aplikacije je doseženo dinamično ravnovesje, ki se nato vzdržuje pri nadaljnih uporabah obližev enake velikosti.
Non-clinical data reveal no special hazard for humans based on conventional studies of repeated dose toxicity.
Neklinični podatki na osnovi običajnih študij toksičnosti pri ponavljajočih odmerkih ne kažejo posebnega tveganja za človeka.
After the first DUROGESIC application, serum fentanyl concentrations increase gradually, generally leveling off between 12 and 24 hours and remaining relatively constant for the remainder of the 72-hour application period.
Po začetni aplikaciji zdravila DUROGESIC serumske koncentracije fentanila postopno naraščajo, se po približno 12-24 urah ustalijo in nato ostanejo sorazmerno konstantne do 72 ur po aplikaciji.
Severe and unpredictable interactions with MAOIs, involving the potentiation of opiate effects or the potentiation of serotoninergic effects, have been reported.
Poročani so bili primeri hudih in nepredvidljivih interakcij z zaviralci MAO, vključno s povečanimi opioidnimi ali serotoninergičnimi učinki.
DUROGESIC is for transdermal use.
Zdravilo DUROGESIC je za transdermalno uporabo.
Moreover, because fentanyl passes through the placenta, the use of DUROGESIC during childbirth might result in respiratory depression in the newborn infant.
Ker fentanil prehaja skozi placento, bi uporaba zdravila DUROGESIC med porodom lahko povzročila depresijo dihanja pri novorojencu.
This delay is due to the gradual increase in serum fentanyl concentration in the 24 hours following initial patch application.
Razlog je v postopnem večanju koncentracije fentanila v prvih 24-ih urah po prvi aplikaciji obliža.
Some patients may experience significant respiratory depression with DUROGESIC; patients must be observed for these effects.
Pri nekaterih bolnikih se med uporabo zdravila DUROGESIC lahko pojavi resna depresija dihanja, zato je treba bolnike skrbno spremljati.
Severe respiratory depression.
Huda depresija dihanja.
• Some antibiotics used to treat infection (such as erythromycin or clarithromycin).
• Nekatere antibiotike za zdravljenje okužb (kot sta eritromicin ali klaritromicin).
DUROGESIC and associated names (see Annex I) 12 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 25 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 50 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 75 micrograms/hour transdermal patch DUROGESIC and associated names (see Annex I) 100 micrograms/hour transdermal patch
DUROGESIC in povezana imena (glejte Prilogo I ) 12 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 25 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 50 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 75 mikrogramov/h transdermalni obliž DUROGESIC in povezana imena (glejte Prilogo I) 100 mikrogramov/h transdermalni obliž
DUROGESIC should not be used during childbirth as the medication can affect the breathing of the newborn child.
Zdravila DUROGESIC ne smete uporabljati med porodom, saj lahko vpliva na dihanje novorojenčka.
{Name and address} <{tel}> <{fax}> <{e-mail}> <This medicinal product is authorised in the Member States of the EEA under the following names:> <{Name of the Member State}> <{Name of the medicinal product}> <{Name of the Member State}> <{Name of the medicinal product}> [See Annex I - To be completed nationally]
To zdravilo je odobreno v državah članicah EGP pod naslednjimi imeni:
If discontinuation of DUROGESIC is necessary, replacement with other opioids should be gradual, starting at a low dose and increasing slowly.
Če je potrebno zdravljenje z zdravilom DUROGESIC prekiniti, mora biti nadomeščanje z drugimi opioidi postopno; začnemo z majhnimi odmerki, ki jih postopno povečujemo.
The safety of DUROGESIC was evaluated in 3 open-label studies in 289 paediatric subjects with chronic pain, aged 2 to 17 years, inclusive.
Varnost zdravila DUROGESIC so ocenili v 3 odprtih študijah pri 289 pediatričnih preiskovancih s kroničnimi bolečinami, starih od 2 do 17 let.
Following DUROGESIC application, the skin under the system absorbs fentanyl, and a depot of fentanyl concentrates in the upper skin layers.
Po namestitvi zdravila DUROGESIC koža pod njim absorbira fentanil in depo fentanila je koncentriran v zgornjih plasteh kože.
Central nervous system depressants may increase the respiratory depression (see section 4.5).
Zdravila z delovanjem na osrednje živčevje lahko poslabšajo depresijo dihanja (glejte poglavje 4.5).
• The following table shows you when to change your patch:
• Spodnja preglednica vam prikazuje na kateri dan v tednu morate obliž zamenjati:
Adjustment of the individual fentanyl dose must be based on the patient's response and level of tolerance.
Prilagajanje odmerka fentanila pri vsakem posameznem bolniku mora temljiti na njegovem odzivu in stopnji tolerance.
In young children, the upper back is the preferred location to minimize the potential of the child removing the patch.
Pri majhnih otrocih se priporoča aplikacija na zgornji del hrbta, da kar se da zmanjšamo možnost, da si otrok sam odstrani obliž.
The major metabolite, norfentanyl, and other metabolites are inactive.
Glavni presnovek norfentanil in ostali presnovki niso aktivni.
What DUROGESIC is and what it is used for What you need to know before you use DUROGESIC How to use DUROGESIC
Kaj je zdravilo DUROGESIC in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo DUROGESIC Kako uporabljati zdravilo DUROGESIC
0.23b diamorphine oral parenteral
0,23b diamorfin peroralna parenteralna
cyproheptadine, diphenhydramine, or hydroxyzine).
ciproheptadin, difenhidramin ali hidroksizin).
There was no indication of teratogenic effects in studies in two species (rats and rabbits).
V študijah na dveh živalskih vrstah (podgane in kunci) ni bilo nobenih znakov teratogenih učinkov.
If paralytic ileus is present or suspected, treatment with DUROGESIC should be stopped.
Če je prisoten paralitični ileus ali sum nanj, je potrebno zdravljenje z zdravilom DUROGESIC prekiniti.
Monoamine Oxidase Inhibitors (MAOI)
Zaviralci monoaminooksidaze (zaviralci MAO)
Use of DUROGESIC during childbirth is not recommended because it should not be used in the management of acute or postoperative pain (see section 4.3).
Uporaba zdravila DUROGESIC med porodom ni priporočljiva, ker se fentanil ne sme uporabljati za lajšanje akutnih ali pooperativnih bolečin (glejte poglavje 4.3).
The potential for serious or life-threatening hypoventilation exists regardless of the dose of DUROGESIC transdermal system administered.
Obstaja možnost pojava resne ali življenjsko nevarne hipoventilacije, neodvisno od odmerka zdravila DUROGESIC.
Eczema, Dermatitis allergic, Skin disorder,
eritem ekcem, alergijski dermatitis, bolezni kože, dermatitis, kontaktni dermatitis
The patch should be used only on the skin of the person for whom it has been prescribed.
Prenos obliža na drugo osebo Obliž je namenjen samo uporabi na koži bolnika, kateremu je zdravilo predpisal zdravnik.
The dose should be titrated individually on the basis of average daily use of supplemental analgesics, until a balance between analgesic efficacy and tolerability is attained.
Odmerek je treba prilagajati individualno in upoštevati povprečni dnevni odmerek dodatnega analgetičnega zdravljenja, dokler ne dosežemo ravnovesja med analgetično učinkovitostjo in prenašanjem zdravila.
Of these 110 subjects, 23 (20.9%) had previously been receiving <30 mg of oral morphine equivalents per day, 66 (60.0%) had been receiving 30 to 44 mg of oral morphine equivalents per day, and 12 (10.9%) had been receiving at least 45 mg of oral morphine equivalents per day (data not available for 9 [8.2%] subjects).
Od teh 110 bolnikov jih je 23 (20,9 %) predhodno prejemalo odmerek opioida, ki ustreza < 30 mg peroralnega morfina na dan, 66 (60 %) jih je prejemalo odmerek opioida, ki ustreza 30 do 40 mg peroralnega morfina na dan in 12 (10,9 %) jih je prejemalo odmerek opioida, ki ustreza najmanj 45 mg peroralnega morfina na dan (za 9 [8,2 %] preiskovancev pa ni dostopnih podatkov).
Central Nervous System conditions including increased intracranial pressure DUROGESIC should be used with caution in patients who may be particularly susceptible to the intracranial effects of CO2 retention such as those with evidence of increased intracranial pressure, impaired consciousness, or coma.
Zdravilo DUROGESIC je treba uporabljati previdno pri bolnikih, ki so lahko posebej dovzetni za intrakranialne učinke zadrževanja CO2, npr. pri bolnikih z zvišanim intrakranialnim tlakom, motnjami zavesti ali komo.
Pharmacokinetic/Pharmacodynamic Relationships
Farmakokinetično/farmakodinamično razmerje
Your doctor will be able to tell you how long you can expect to use the patches
kako dolgo lahko pričakujete, da boste uporabljali obliže.