natgillin/translations-raw huggingface dataset:
A total of 820 patients were randomised.
Skupno so randomizirali 820 bolnikov.
Date of latest renewal: 14 January 2015
Datum prve odobritve: 12. januar 2005 Datum zadnjega podaljšanja: 14. januar 2015
Studies to evaluate the mutagenic and carcinogenic potential of bevacizumab have not been performed.
Študij za oceno mutagenega in kancerogenega potenciala bevacizumaba niso izvajali.
For further information as to human epidermal growth factor receptor 2 (HER2) status, please refer to section 5.1.
Za dodatne informacije glede statusa receptorja humanega epidermalnega rastnega faktorja 2 (HER2) prosimo glejte poglavje 5.1.
In trial E2100, patients were treated until disease progression.
V preskušanju E2100 so bolnike zdravili do napredovanja bolezni.
Very rare cases of hypertensive encephalopathy have been reported, some of which were fatal.
Poročali so o zelo redkih primerih hipertenzivne encefalopatije, od katerih so bili nekateri smrtni.
When Avastin is injected directly into the eye (unapproved use), the following side effects may occur:
Kadar zdravilo Avastin injiciramo neposredno v oko (neodobrena uporaba), se lahko pojavijo naslednji neželeni učinki:
Prior hormonal therapy for the treatment of metastatic disease was allowed.
Za zdravljenje metastatske bolezni je bilo dovoljeno predhodno hormonsko zdravljenje.
• high blood pressure,
· visok krvni tlak,
Metastatic disease progression was inhibited and microvascular permeability was reduced.
Napredovanje metastatske bolezni je bilo zavrto, mikrovaskularna prepustnost pa zmanjšana.
IRF assessment
Ocena IRF
Women of childbearing potential have to use effective contraception during (and up to 6 months after) treatment.
Ženske v rodni dobi morajo uporabljati učinkovito kontracepcijo med zdravljenjem in do 6 mesecev po njem.
There is insufficient information to determine the safety and efficacy of bevacizumab in children with newly-diagnosed high-grade glioma.
Na voljo ni dovolj podatkov, da bi določili varnost in učinkovitost bevacizumaba pri otrocih z novo diagnosticiranim gliomom visoke stopnje malignosti.
Elderly patients: No dose adjustment is required in the elderly.
Posebne populacije Starejši bolniki: za starejše bolnike prilagajanje odmerka ni potrebno.
Information on foetal malformations observed in the post marketing setting are provided in section 4.6 Fertility, Pregnancy and Lactation and 4.8 Undesirable Effects.
Podatki o malformacijah ploda, ki so jih opazili v obdobju po prihodu zdravila na trg, so vključeni v poglavje 4.6 Plodnost, nosečnost in dojenje ter 4.8 Neželeni učinki.
Dose reduction for adverse reactions is not recommended.
Zmanjšanje odmerka zaradi neželenih učinkov ni priporočljivo.
● This medicine may cause infections and a decreased number of your neutrophils (a type of blood cell important for your protection against bacteria).
· to zdravilo lahko povzroči okužbe in zmanjša število vaših nevtrofilcev (vrsta krvnih celic, ki so pomembne za zaščito pred bakterijami);
• post-authorisation safety studies,
· v varnostnih študijah po pridobitvi dovoljenja za promet;
Any unused medicinal product or waste material should be disposed in accordance with local requirements.
Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
Please consult your doctor, even if these above statements were only applicable to you in the past.
Prosimo, da se posvetujete s svojim zdravnikom, če so se zgoraj navedene navedbe na vas nanašale v preteklosti.
Each pack of Avastin contains one vial.
Vsako pakiranje zdravila Avastin vsebuje 1 vialo.
Invasive dental procedures are also an identified risk factor.
Invazivni zobozdravstveni posegi predstavljajo dodatni dejavnik tveganja.
A systematic premedication is not warranted.
Sistematska premedikacija ni potrebna.
These could be signs and symptoms of bone damage in the jaw (osteonecrosis).
Le-ti so lahko znaki in simptomi poškodbe kosti v čeljusti (osteonekroze).
If you have an allergic reaction, tell your doctor or a member of the medical staff straight away.
Če se pri vas pojavi alergijska reakcija, nemudoma obvestite zdravnika ali člana medicinskega osebja.
Do not stop treatment with Avastin unless you have discussed this with your doctor.
Ne prenehajte zdravljenja z zdravilom Avastin, ne da bi se o tem pogovorili s svojim zdravnikom.
FIGO staging version dated 1988 was used in this trial.
V tem preskušanju so uporabili klasifikacijo FIGO, verzija iz leta 1988.
It is not known whether bevacizumab is excreted in human milk.
Ni znano, ali se bevacizumab izloča v materino mleko.
Therefore, caution should be exercised before initiating therapy in these patients.
Zato je pred začetkom zdravljenja pri teh bolnikih potrebna previdnost.
F. Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Switzerland
F. Hoffmann-La Roche Ltd Grenzacherstrasse 124 CH-4070 Basel Švica
● It is possible that Avastin can cause hypersensitivity and/or infusion reactions (reactions related to your injection of the medicine).
· možno je, da lahko zdravilo Avastin povzroči preobčutljivost in/ali reakcije, povezane z infundiranjem (reakcije, povezane z injiciranjem zdravila).
Please discuss with your doctor if you noticed this previously.
Pogovorite se s svojim zdravnikom, če ste to že kdaj opazili;
Long term effects of the treatment with bevacizumab on fertility are unknown.
Dolgoročni vplivi zdravljenja z bevacizumabom na plodnost niso znani.
Effects on wound healing were shown to be fully reversible.
Učinki na celjenje ran so bili popolnoma reverzibilni.
Data are unadjusted for the differential time on treatment.
Podatki niso prilagojeni različno dolgi dobi zdravljenja.
Before initiating Avastin, this risk should be carefully considered in patients with risk factors such as hypertension or history of aneurysm.
Pred uvedbo zdravila Avastin je treba to tveganje skrbno preučiti pri bolnikih z dejavniki tveganja, kot sta hipertenzija ali anamneza anevrizme.
In patients who have previously received or are receiving intravenous bisphosphonates invasive dental procedures should be avoided, if possible.
Pri bolnikih, ki so predhodno prejemali ali trenutno prejemajo intravenske difosfonate, se je treba, če je to mogoče, izogibati invazivnim zobozdravstvenim posegom.
Please discuss this with your doctor if you have metastatic cancer affecting your brain.
Posvetujte se s svojim zdravnikom, če imate rak v metastatski obliki, ki je prizadel vaše možgane;
Later infusions may be given to you over 30 minutes.
Nadaljnje infuzije boste lahko prejeli v 30 minutah.
Pre-menopausal women (women who have a menstrual cycle) may notice that their periods become irregular or are missed and may experience impaired fertility.
Predmenopavzalne ženske (ženske z menstrualnim ciklom) boste morda opazile, da bodo vaše menstruacije postale neredne ali bodo izostale, oziroma bo vaša plodnost zmanjšana.
There are no clinical trial data on the use of Avastin in pregnant women.
Iz kliničnih preskušanj ni podatkov o uporabi zdravila Avastin pri nosečnicah.
It is important that your doctor knows if you have ever received anthracyclines (for example doxorubicin, a specific type of chemotherapy used to treat some cancers) or had radiotherapy to your chest, or if you have heart disease.
Pomembno je, da vaš zdravnik ve, če ste kdaj prejeli antracikline (na primer doksorubicin, specifično vrsto kemoterapije, ki jo uporabljajo pri zdravljenju nekaterih vrst raka), če so vam obsevali prsni koš ali če imate srčno bolezen;
A total of 16 patients (4.4%) were > 75 years old.
Skupaj je bilo 16 bolnic (4,4 %) starejših od 75 let.
If you experience symptoms that affect your vision or concentration, or your ability to react, do not drive and use machines until symptoms disappear.
Če se pri vas pojavijo simptomi, ki vplivajo na vid oziroma koncentracijo ali vašo sposobnost odzivanja, ne vozite ali uporabljajte strojev, dokler simptomi ne izginejo.
It is recommended that treatment be continued until disease progression or unacceptable toxicity (see section 5.1, study MO22224).
Priporočljivo je, da se zdravljenje nadaljuje do napredovanja bolezni ali nesprejemljive toksičnosti (glejte poglavje 5.1, študija MO22224).
However, the increase in the primary endpoint of overall survival by 2 months was not significant (HR= 0.91).
Vendar pa povečanje primarnega končnega cilja - celokupnega preživetja - za 2 meseca ni bilo signifikantno (razmerje ogroženosti = 0,91).
You should discuss this with your doctor.
O tem se pogovorite s svojim zdravnikom.
Major or massive pulmonary haemorrhage/haemoptysis can occur suddenly and up to two thirds of the serious pulmonary haemorrhages resulted in a fatal outcome.
Večja ali masivna krvavitev v pljučih/hemoptiza se lahko pojavi nenadoma, pri do dveh tretjinah resnih krvavitev v pljučih je prišlo do smrtnega izida.
There were no grade 4 or 5 hypertension events.
Hipertenzije stopnje 4 ali 5 niso opazili.
High-grade glioma
Gliom visoke stopnje
Tell your doctor straightaway if you are pregnant, become pregnant during treatment with this medicine, or plan to become pregnant in the near future.
Svojemu zdravniku takoj povejte, če ste noseči, če ste med zdravljenjem s tem zdravilom zanosili ali če v kratkem načrtujete zanositev.
The safety and efficacy of concomitant administration of radiotherapy and Avastin has not been established.
Varnost in učinkovitost sočasnega zdravljenja z radioterapijo in zdravilom Avastin nista bili ugotovljeni.
Adverse reactions are added to the appropriate frequency category in the tables below according to the highest incidence seen in any indication.
Neželeni učinki so v spodnjih preglednicah razdeljeni v ustrezno skupino po pogostnosti glede na najvišjo incidenco, ki so jo opazili pri kateri koli indikaciji.
A cross-trial comparison of the efficacy and safety data is limited by differences between these studies, most notably in patient populations, previous bevacizumab exposure and chemotherapy regimens.
Primerjava podatkov o učinkovitosti in varnosti med študijama je omejena zaradi razlik med njima, še posebej v populaciji bolnikov, predhodni izpostavljenosti bevacizumabu in uporabljeni kemoterapiji.
There were no complete responses and 2 partial responses (MacDonald criteria).
Popolnih odgovorov na zdravljenje ni bilo, bila pa sta 2 delna odgovora na zdravljenje (kriterij po Macdonaldu).
Final overall survival analysis performed when 46.9% of the patients had died.
Končna analiza celokupnega preživetja je bila narejena, ko je približno 46,9 % bolnic umrlo.
● This medicine increases the risk of having protein in your urine especially if you already have high blood pressure.
· to zdravilo poveča tveganje za pojav beljakovin v seču, še posebej, če že imate visok krvni tlak;
Efficacy results for study JO25567
Rezultati učinkovitosti študije JO25567
Symptoms usually resolve or improve within days after treatment discontinuation, although some patients have experienced some neurologic sequelae.
Simptomi ponavadi izginejo ali se izboljšajo v nekaj dneh po prekinitvi zdravljenja, kljub temu so nekateri bolniki imeli nevrološke posledice.
Q2 2019
2. četrtletje 2019
If you are going to have an operation, if you have had major surgery within the last 28 days or if you still have an unhealed wound following surgery, you should not receive this medicine.
Če boste operirani, če je od večje operacije minilo manj kot 28 dni, ali če se vaša rana po operaciji še ni zacelila, tega zdravila ne smete prejeti;
• feeling weak and having no energy,
· občutek šibkosti in pomanjkanja energije,
Combinations of Avastin with another medicine called sunitinib malate (prescribed for renal and gastrointestinal cancer) may cause severe side effects.
Kombinacija zdravila Avastin z drugim zdravilom, imenovanim sunitinib malat (predpisanem za zdravljenje raka ledvic in prebavil), lahko povzroči hude neželene učinke.
Avastin use is not recommended in children and adolescents under the age of 18 years because the safety and benefit have not been established in these patient populations.
Uporaba zdravila Avastin ni priporočena pri otrocih in mladostnikih, mlajših od 18 let, ker varnosti in koristi zdravila pri tej populaciji niso dokazali.
In addition, the primary endpoint was also assessed by an independent review committee (IRC).
Dodatno je primarni cilj ocenil tudi odbor za neodvisni pregled (IRC, independent review committee).
The majority of patients (CP: 64.6%; CPB: 68.8%) were in the age category < 65 years.
Večina bolnic (CP: 64,6 %; CPB: 68,8 %) je bila iz starostne skupine < 65 let.
* Primary analysis was performed with a data cut-off date of 14 November 2011.
*Primarna analiza je bila pripravljena s podatki, zajetimi do 14. novembra 2011.
Objective Response Rate**
Objektivni odgovor**
The median age of patients was 61.0 (range: 25−84) years.
Mediana starosti bolnic je bila 61,0 let (razpon: 25 do 84 let).
Table 2 also includes adverse reactions which are considered by the MAH to be clinically significant or severe.
Preglednica 2 vključuje tudi neželene učinke, za katere imetnik dovoljenja za promet smatra, da so klinično pomembni ali hudi.
In the chemotherapy arms, the FOLFOX-4 regimen used the same doses and schedule as shown in Table 6 for trial NO16966.
V skupini, ki je prejemala kemoterapijo, so pri zdravljenju po shemi FOLFOX-4 uporabljali enake odmerke in sheme, kot je prikazano v preglednici 6 za preskušanje NO16966.
Repeat dose toxicity studies in animals have shown that bevacizumab may have an adverse effect on female fertility (see section 5.3).
Študije toksičnosti pri ponavljajočih se odmerkih na živalih so pokazale, da ima bevacizumab lahko škodljiv učinek na plodnost žensk (glejte poglavje 5.3).
Secondary endpoints included overall survival, response rate, disease control rate, duration of response, and safety.
Sekundarni cilji so vključevali celokupno preživetje, odgovor na zdravljenje, stopnjo nadzora bolezni, trajanje odgovora in varnost.
● This medicine can increase the risk of bleeding or increase the risk of problems with wound healing after surgery.
· to zdravilo lahko poveča tveganje za krvavitve ali poveča tveganje za težave pri celjenju ran po operaciji.
The pharmacokinetics of bevacizumab was linear at doses ranging from 1 to 10 mg/kg.
Farmakokinetika bevacizumaba je bila linearna pri odmerkih v intervalu od 1 do 10 mg/kg.
It rarely resulted in discontinuation of Avastin treatment or hospitalisation.
Redko je prišlo do prekinitve zdravljenja z zdravilom Avastin ali hospitalizacije.
A high proportion of patients (approximately 62%) went on to receive a variety of non-protocol specified anticancer therapies, which may have impacted the analysis of overall survival.
Velik del bolnikov (približno 62 %) je prejemal različna zdravila za zdravljenje novotvorb, ki niso bila določena v protokolu študije, kar je lahko vplivalo na analizo celokupnega preživetja.
On documented disease progression, patients who entered the optional open-label phase could receive open-label Avastin together with a wide-range of second line therapies.
Pri dokumentiranem napredovanju bolezni so lahko bolniki, ki so vstopili v opcijsko odprto fazo, odprto prejemali zdravilo Avastin skupaj z različnimi vrstami zdravljenj v drugi liniji.
A total of 1873 patients were randomised in equal proportions to the following three arms:
Skupno je bilo randomiziranih 1873 bolnic v enakem razmerju v naslednje tri skupine:
b stratified by the duration of treatment free-interval prior to enrolling onto this study per the registration form, and secondary surgical debulking status Yes/No.
b stratificirane s trajanjem intervala brez zdravljenja pred vključitvijo v to študijo glede na registracijski obrazec in sekundarno s statusom kirurške odstranitve Da/Ne.
What Avastin is and what it is used for
Kaj je zdravilo Avastin in za kaj ga uporabljamo
This study included a blinded treatment phase, an optional open-label post-progression phase, and a survival follow-up phase.
To preskušanje je vključevalo fazo s slepim zdravljenjem, opcijsko odprto fazo po napredovanju bolezni in nadaljevalno fazo, v kateri so spremljali preživetje.
● A rare neurological side effect named posterior reversible encephalopathy syndrome (PRES) has been associated with Avastin treatment.
· redek neželen učinek, povezan z živci, imenovan sindrom posteriorne reverzibilne encefalopatije (PRES), povezujejo z zdravljenjem z zdravilom Avastin.
Detailed information on this medicine is available on the European Medicines Agency (EMA) web site: http://www.ema.europa.eu
Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu.
A. MANUFACTURERS OF THE BIOLOGICAL ACTIVE SUBSTANCE AND MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
A. IZDELOVALCI BIOLOŠKE ZDRAVILNE UČINKOVINE IN IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE
If you have conditions causing inflammation inside the abdomen (e.g. diverticulitis, stomach ulcers, colitis associated with chemotherapy), please discuss this with your doctor.
Če imate stanje, ki povzroča trebušno vnetje (npr. divertikulitis, želodčno razjedo, s kemoterapijo povezan kolitis), se o tem pogovorite s svojim zdravnikom;
Table 2 provides the frequency of severe adverse reactions.
Preglednica 2 navaja pogostnost hudih neželenih učinkov.
MARKETING AUTHORISATION NUMBER(S) EU/1/04/300/001 - 100 mg/4 ml vial EU/1/04/300/002 - 400 mg/16 ml vial
EU/1/04/300/001 - 100 mg/4 ml viala EU/1/04/300/002 - 400 mg/16 ml viala
Objective Response Rate 1
Objektivni odgovor 1
If a reaction occurs, the infusion should be discontinued and appropriate medical therapies should be administered.
Če pride do reakcije, je treba infundiranje prekiniti ter uvesti ustrezno zdravljenje.
Please tell your doctor if you have recently received, or are receiving, radiotherapy.
Prosimo, obvestite svojega zdravnika, če ste pred kratkim prejeli ali prejemate zdravljenje z obsevanjem.
An independent review of the primary endpoint was also conducted.
Opravljen je bil tudi neodvisen pregled primarnega cilja.
Avastin is not approved for use in patients under the age of 18 years.
Zdravilo Avastin ni odobreno za uporabo pri bolnikih, mlajših od 18 let.
After correcting for body weight, male patients had a higher bevacizumab clearance (+ 17%) than females.
Po prilagoditvi glede na telesno maso so imeli bolniki višji očistek bevacizumaba (+17 %) kot bolnice.
Patients with recent pulmonary haemorrhage/ haemoptysis (> 2.5 ml of red blood) should not be treated with Avastin.
Bolnike, ki so nedavno imeli krvavitev v pljučih/hemoptizo (> 2,5 ml rdeče krvi), z zdravilom Avastin ne smemo zdraviti.
There is evidence suggesting that all Grade (US National Cancer InstituteCommon Terminology Criteria for Adverse Events [NCI-CTCAE v.3]) proteinuria may be related to the dose.
Obstajajo dokazi, da je proteinurija vseh stopenj (US National Cancer InstituteCommon Terminology Criteria for Adverse Events [NCI-CTCAE v.3]) lahko povezana z odmerkom.
b Terms represent a group of events that describe a medical concept rather than a single condition or MedDRA (Medical Dictionary for Regulatory Activities) preferred term.
b Termini predstavljajo skupino neželenih učinkov, ki opisujejo medicinski pojem namesto posameznega stanja ali prednostni izraz po MedDRA (Medical Dictionary for Regulatory Activites).
B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Medicinal product subject to restricted medical prescription (see Annex: Summary of Product Characteristics, section 4.2).
B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE Predpisovanje in izdaja zdravila je le na recept s posebnim režimom (Glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
878 patients were randomised to the two arms.
878 bolnikov je bilo randomiziranih v dve skupini.
The highest dose tested in humans (20 mg/kg of body weight, intravenous every 2 weeks) was associated with severe migraine in several patients.
Največji odmerek, ki so ga preizkušali pri ljudeh (20 mg/kg telesne mase, intravensko na 2 tedna), je bil pri nekaj bolnikih povezan s hudo migreno.
Intravitreal use Avastin is not formulated for intravitreal use.
Intravitrealna uporaba Zdravilo Avastin ni namenjeno intravitrealni uporabi.
Avastin therapy should be discontinued in patients who develop necrotising fasciitis, and appropriate treatment should be promptly initiated.
Zdravljenje z zdravilom Avastin je treba pri bolnikih, pri katerih se razvije nekrotizirajoči fasciits, nemudoma prekiniti in takoj začeti z ustreznim zdravljenjem.
Best Overall Response - Primary analysis6
Najboljši celokupni odgovor na zdravljenje - primarna analiza6
The pharmacokinetic data for bevacizumab are available from ten clinical trials in patients with solid tumours.
Na voljo so farmakokinetični podatki o bevacizumabu iz desetih kliničnih preskušanj pri bolnikih s solidnimi tumorji.
Avastin contains the active substance bevacizumab, which is a humanised monoclonal antibody (a type of protein that is normally made by the immune system to help defend the body from infection and cancer).
Zdravilo Avastin vsebuje zdravilno učinkovino bevacizumab, ki je humanizirano monoklonsko protitelo (vrsta beljakovine, ki jo običajno proizvaja imunski sistem, da pomaga telesu pri obrambi proti okužbam in raku).
Avastin is contraindicated in pregnancy (see section 4.3).
Zdravilo Avastin je kontraindicirano med nosečnostjo (glejte poglavje 4.3).
In studies of up to 26 weeks duration in cynomolgus monkeys, physeal dysplasia was observed in young animals with open growth plates, at bevacizumab average serum concentrations below the expected human therapeutic average serum concentrations.
V študijah na opicah cynomolgus, ki so trajale do 26 tednov, so pri mladih živalih z odprtimi rastnimi ploščami opazili fizalno displazijo pri srednjih koncentracijah bevacizumaba v serumu, ki so bile pod pričakovanimi povprečnimi terapevtskimi koncentracijami v serumu pri ljudeh.
The incidence of each histologic sub-type of EOC was similar between the treatment arms; 69% of patients in each treatment arm had serous adenocarcinoma histologic type.
Incidenca vseh histoloških podtipov epitelijskega raka jajčnikov je bila podobna v obeh skupinah; 69 % bolnic v vsaki skupini je imelo serozni histološki tip adenokarcinoma.
19% of the patients had received prior chemotherapy and 14% prior radiotherapy.
19 % teh bolnikov je predhodno prejemalo kemoterapijo, 14 % pa radioterapijo.
Do not use Avastin if you notice any particulate matter or discolouration prior to administration.
Ne uporabljajte zdravila Avastin, če opazite kakršne koli delce ali obarvanje pred dajanjem.
After discontinuation of bevacizumab treatment, ovarian function recovered in 86.2% of these evaluable women.
Po prekinitvi zdravljenja z bevacizumabom se je delovanje jajčnikov izboljšalo pri 86,2 % opazovanih žensk.
The population pharmacokinetics were analysed in adult and pediatric patients to evaluate the effects of demographic characteristics.
Pri odraslih in pediatričnih bolnikih so z analizo populacijske farmakokinetike proučili vpliv demografskih značilnosti na farmakokinetiko .
The safety and efficacy of bevacizumab in children less than 18 years old have not been established.
Varnost in učinkovitost bevacizumaba pri otrocih, mlajših od 18 let, nista bili dokazani.
● Avastin may increase the risk of developing an abnormal connection or passageway between two organs or vessels.
· zdravilo Avastin lahko poveča tveganje za razvoj neobičajne povezave ali prehoda med dvema organoma ali žilami.
The initial dose should be delivered over 90 minutes as an intravenous infusion.
Začetni odmerek je treba dajati v obliki intravenske infuzije 90 minut.
XELOX or XELOX + Avastin
XELOX ali XELOX+ Avastin
Among the 110 patients randomised to Arm 3 (5-FU/FA + Avastin) prior to discontinuation of this arm, the median overall survival was 18.3 months and the median progression free survival was 8.8 months.
Med 110 bolniki, randomiziranimi v skupino 3 (5-FU/FA + Avastin), je bila mediana celokupnega preživetja pred ukinitvijo te skupine 18,3 meseca, mediana preživetja brez napredovanja bolezni pa 8,8 meseca.
What Avastin is and what it is used for What you need to know before you use Avastin How to use Avastin
Kaj je zdravilo Avastin in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Avastin Kako uporabljati zdravilo Avastin