natgillin/translations-raw huggingface dataset:
Clinical efficacy and safety in the paediatric population The efficacy of propranolol in infants (aged 5 weeks to 5 months at treatment initiation) with proliferating infantile haemangioma requiring systemic therapy has been demonstrated in a pivotal randomised, controlled, multicentre, multidose, adaptive phase II/III study aimed to compare four regimens of propranolol (1 or 3 mg/kg/day for 3 or 6 months) to placebo (double blind).
Klinična učinkovitost in varnost pri pediatrični populaciji Učinkovitost propranolola pri dojenčkih (starosti od 5 tednov do 5 mesecev na začetku zdravljenja) z močno povečanim infantilnim hemangiomom, ki zahteva sistematično zdravljenje, je bila dokazana v osrednji randomizirani, nadzorovani, multicentrični študiji faze II/III z več odmerki z možnim prilagajanjem, katere cilj je bil primerjava štirih režimov propranolola (1 ali 3 mg/kg/dan 3 ali 6 mesecev) in placeba (dvojno slepa).
The pharmacokinetics of repeated administrations of HEMANGIOL at 3 mg/kg/day given in 2 intakes has been investigated in 19 infants aged 35 to 150 days at the beginning of treatment.
Farmakokinetika ponavljajoče uporabe zdravila HEMANGIOL v odmerku 3 mg/kg/dan v dveh vnosih je bila raziskana pri 19 dojenčkih v starosti od 35 do 150 dni na začetku zdravljenja.
What you need to know before your child receives HEMANGIOL 3.
Kaj morate vedeti, preden vaš otrok prejme zdravilo HEMANGIOL 3.
Co-administration with any substrate for alcohol dehydrogenase such as ethanol may induce serious adverse effects in neonates.
Sočasno dajanje s katerim koli substratom za alkohol-dehidrogenazo, kot je etanol, lahko pri novorojenčkih vodi do resnih neželenih učinkov.
When a patient is scheduled for surgery, beta-blocker therapy should be discontinued at least 48 hours prior to the procedure.
Ko je bolnik načrtovan za operacijo, je treba zdravljenje z antagonisti adrenergičnih receptorjev beta prekiniti vsaj 48 ur pred posegom.
In the absence of clinical efficacy and safety data, HEMANGIOL should not be used in infants aged below 5 weeks.
Zaradi pomanjkanja podatkov o klinični učinkovitosti in varnosti zdravila HEMANGIOL ni dovoljeno uporabljati pri dojenčkih, mlajših od 5 tednov.
In case of suspected cardiac abnormality, a specialist advice must be sought before treatment initiation to determine any subjacent contra-indication.
V primeru suma na srčne nepravilnosti je treba pred začetkom zdravljenja pridobiti nasvet strokovnjaka, da se ugotovijo morebitne spodnje kontraindikacije.
In animals, after an acute dosing, propranolol is considered as a moderately toxic drug with an oral LD50 of about 600 mg/kg.
Pri živalih se po akutnem odmerku propranolol šteje za zmerno toksično zdravilo s peroralno LD50 približno 600 mg/kg.
This medicine can mask the warning signs of hypoglycaemia (also known as low blood sugar level), especially if the baby is fasting, vomiting or in case of overdose.
Zdravilo lahko zakrije opozorilne znake hipoglikemije (znana tudi kot nizka raven sladkorja v krvi), zlasti če dojenček ne je, če bruha ali v primeru prevelikega odmerka.
• If necessary, you may mix the medicine with a small quantity of baby-milk or age-adapted apple and/or orange fruit juice and give it to your child in a baby bottle.
• Po potrebi lahko zdravilo razredčite z majhno količino mleka ali starosti prilagojenega jabolčnega in/ali pomarančnega sadnega soka in ga dajte otroku prek otroške stekleničke.
HEMANGIOL should be administered for a 6-month period.
Zdravilo HEMANGIOL je treba dajati 6 mesecev.
If your child has any signs of hypoglycaemia while taking HEMANGIOL, give if possible oral liquid containing sugar and, if symptoms persist, call your doctor right away or go directly to hospital.
Če ima otrok med jemanjem zdravila HEMANGIOL kakršne koli znake hipoglikemije, mu dajte, če je mogoče, peroralno tekočino, ki vsebuje sladkor, in če simptomi ne izginejo, takoj pokličite zdravnika ali pojdite v bolnišnico.
Skin and subcutaneous tissue disorders
Bolezni kože in podkožnega tkiva
The name of your medicine is HEMANGIOL.
Vaše zdravilo se imenuje HEMANGIOL.
During this pharmacokinetic study including infants with function-threatening haemangioma, haemangioma in certain anatomic locations that often leave permanent scars or deformity, large facial haemangioma, smaller haemangioma in exposed areas, severe ulcerated haemangioma, pedunculated haemangioma, efficacy was also studied as a secondary evaluation criteria.
Med to farmakokinetično študijo, ki je vključevala dojenčke s hemangiomom, ki je ogrožal telesne funkcije, hemangiomom na določenih anatomskih lokacijah, ki pogosto pustijo trajne brazgotine ali deformacije, z velikim hemangiomom na obrazu, manjšim hemangiomom na izpostavljenih območjih, s hudim ulceriranim hemangiomom, pedunkularnim hemangiomom, je bila prav tako raziskana učinkovitost kot sekundarni kriterij ocenjevanja.
• Sleep disorders (insomnia, poor quality of sleep and difficulties to wake-up),
• motnje spanja (nespečnost, slaba kakovost spanja in težave pri prebujanju),
• Medicines to treat pain and inflammation,
• zdravila za lajšanje bolečin in vnetja,
- Information on how to detect and manage any sign of hypoglycaemia during treatment with HEMANGIOL
- podatki o tem, kako odkriti in ravnati v primeru katerih koli znakov hipoglikemije med zdravljenjem z zdravilom HEMANGIOL,
Sleep disorders corresponded to insomnia, poor quality of sleep and hypersomnia.
Motnje spanja so bile nespečnost, slaba kakovost spanja in hipersomnija.
In vitro studies indicated that CYP2D6 (aromatic hydroxylation), CYP1A2 (chain oxidation) and to a less extent CYP2C19 were involved in propranolol metabolism.
Študije in vitro so pokazale, da so bili v presnovo propranolola vključeni CYP2D6 (aromatična hidroksilacija), CYP1A2 (oksidacija verige) in v manjšem obsegu CYP2C19.
HEMANGIOL is indicated in the treatment of proliferating infantile haemangioma requiring systemic therapy:
je indicirano za zdravljenje hitro rastočega infantilnega hemangioma, ki zahteva sistematično zdravljenje:
However, in the study conducted in juvenile animals treated all over the development period corresponding to infancy, childhood and adolescence, no effect on male and female fertilities was observed (See section 4.6).
Vseeno pa pri raziskavi, izvedeni na juvenilnih živalih skozi celotno razvojno obdobje, ki pri ljudeh ustreza obdobju od dojenčka prek otroka do adolescence, ni bilo opaženih učinkov na plodnost samcev in samic (glejte poglavje 4.6).
• Erythema (skin redness),
• eritem (rdečica kože),
The medicine should not be put in the full filled bottle.
Zdravila se ne sme vlivati v polno dojenčkovo stekleničko.
It masks the adrenergic warning signs of hypoglycaemia, particularly tachycardia, shakiness, anxiety and hunger.
Zakrije adrenergične opozorilne znake hipoglikemije, zlasti tahikardijo, tresenje, tesnobnost in lakoto.
Similar results were obtained following intra-testicular administration of propranolol and using in vitro models.
Podobni rezultati so bili pridobljeni po dajanju propranolola v moda in uporabi modelov in vitro.
• the absence of cardioselective beta-1 beta-blocking activity,
• odsotnost kardioselektivne beta-1 aktivnosti antagonistov adrenergičnih receptorjev beta,
Here is how to open it: push down the plastic cap while turning the cap counter-clockwise (to the left).
Tako jo odprete: potisnite plastični pokrovček navzdol, medtem pa ga obrnite v nasprotni smeri urnega kazalca (v levo).
Caution should be taken into account in babies less than 4 weeks old, in particular if the baby is given other medicines that contain propylene glycol or alcohol.
Pri dojenčkih, starih do 4 tedne, je potrebna pazljivost, še posebej, če dojenček prejema druga zdravila, ki vsebujejo propilenglikol ali alkohol.
An analysis of the medical history and a full clinical examination must be performed including heart rate, cardiac and pulmonary auscultation.
Treba je izvesti analizo zdravstvene anamneze in celoten kliničen pregled, vključno z avskultacijo srčnega utripa, srca in pljuč.
• An oral polypropylene syringe graduated in mg of propranolol, is provided with each bottle.
• Peroralna polipropilenska brizga, umerjena v mg propranolola je priložena vsaki steklenici.
• Cardiac symptoms of mild to moderate poisoning are decreased heart rate and hypotension.
• Srčna simptoma blage do zmerne zastrupitve sta zmanjšan srčni utrip in hipotenzija.
The toxicity of beta-blockers is an extension of their therapeutic effects:
Toksičnost antagonistov adrenergičnih receptorjev beta je razširitev njihovih zdravilnih učinkov:
Very limited safety data of propranolol in PHACE syndrome patients are available.
Sindrom PHACE Na voljo so zelo omejeni podatki o varnosti propranolola pri bolnikih s sindromom PHACE.
1 NAME OF THE MEDICINAL PRODUCT
1 IME ZDRAVILA
The MAH shall provide an educational pack for the proposed indication, targeting all caregivers who are expected to prepare and administer HEMANGIOL to children.
Imetnik dovoljenja za promet z zdravilom mora zagotoviti izobraževalni paket za predlagano indikacijo, ciljna skupina pa so vsi negovalci, od katerih se pričakuje priprava in dajanje zdravila HEMANGIOL otrokom.
Do not shake the bottle before use.
Ne tresite steklenice pred uporabo.
One case of second degree atrioventricular heart block in a patient with underlying conduction disorder led to definitive treatment discontinuation.
V enem primeru je atrioventrikularni blok druge stopnje pri bolniku z motnjo prevajanja privedel do dokončne prekinitve zdravljenja.
The administration of beta2 agonists and inhaled corticosteroids is possible.
Mogoče je dajanje beta2 agonistov in inhalacijskih kortikosteroidov.
In case the child spits up a dose or does not take all of the medicinal product no other dose should be given before the next scheduled dose.
V primeru, da otrok izpljune odmerek ali ne vzame celotnega odmerka zdravila, mu ne dajajte drugega odmerka pred naslednjim načrtovanim odmerkom.
• If your child spits up a dose or if you are uncertain whether he/she got all of the medicine, do not give another dose, just wait until the next scheduled dose.
• Če otrok izpljune odmerek oz. niste prepričani, ali je prejel celotno zdravilo, mu ne dajte drugega odmerka, ampak počakajte na naslednji načrtovani odmerek.
Propranolol is a substrate for the intestinal efflux transporter, P-glycoprotein (P-gp).
Propranolol je substrat intestinalnega efluksnega transporterja P-glikoproteina (P-gp).
This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i.e. essentially ‘sodiumfree'.
To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na odmerek, kar v bistvu pomeni »brez natrija«.
Age (35-90 days / 91150 days), gender and haemangioma location (head / body) subgroups did not identify differences in response to propranolol.
Pri podskupinah po starosti (od 35 do 90 dni/od 91 do 150 dni), spolu in lokaciji hemangioma (glava/telo) ni bilo odkritih razlik v odzivu na propranolol.
In case of large ulcerated haemangioma,, your child's blood potassium level should be measured.
V primeru velikega ulceriranega hemangioma, je treba otroku meriti raven kalija v krvi.
Please refer to section 2 of this leaflet.
Glejte poglavje 2 tega navodila za uporabo.
Use of propranolol alongside hypoglycaemic therapy in diabetic patients should be with caution since it may prolong the hypoglycaemic response to insulin.
Pri uporabi propranolola skupaj s hipoglikemičnim zdravljenjem pri sladkornih bolnikih je potrebna previdnost, saj lahko podaljša hipoglikemični odziv na inzulin.
The four major final metabolites are propranolol glucuronide, naphthyloxylactic acid and glucuronic acid, and sulfate conjugates of 4-hydroxy propranolol.
Štirje glavni končni presnovki so propranolol glukuronid, naftiloksilaktična kislina in glukuronska kislina ter sulfatni konjugati 4-hidroksi propranolola.
• Asthma or history of bronchospasm
• Astma ali anamneza bronhospazma
Dermatitis psoriasiform
Psoriaziformni dermatitis
Mean apparent oral clearance was 2.71 L/h/kg in infants aged 65- 120 days and 3.27 L/h/kg in infant aged 181- 240 days.
Povprečen opažni peroralni očistek je bil 2,71 l/h/kg pri dojenčkih, starih od 65 do 120 dni, in 3,27 l/h/kg pri dojenčkih, starih od 181 do 240 dni.
In adult male rats, repeated administration of propranolol at high dose levels (≥7.5 mg/kg) induced histopathological lesions of the testes, epididymis, and seminal vesicles, decrease in sperm motility, sperm cell concentration, plasma testosterone levels and significant increase in sperm head and tail abnormalities.
Pri odraslih samcih podgan je ponavljajoče dajanje propranolola z visokimi stopnjami odmerkov (≥ 7,5 mg/kg) povzročilo histopatološke lezije testisov, epididimisa in seminalnih veziklov, zmanjšanje gibljivosti sperme, koncentracije spermijev, nivojev testosterona v plazmi in znatno povečanje nepravilnosti glav in repov spermijev.
If you are breastfeeding your child
Če otroka dojite
It can aggravate hypoglycaemia in children, especially in case of fasting, vomiting or overdose.
Pri otrocih lahko poslabša hipoglikemijo, zlasti v primeru posta, bruhanja ali čezmernega odmerka.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
4 Možni neželeni učinki Kot vsa zdravila ima lahko tudi to zdravilo neželene učinke, ki pa se ne pojavijo pri vseh bolnikih.
4.4 Special warnings and precautions for use
4.4 Posebna opozorila in previdnosti ukrepi
Propranolol passes through breast milk, mothers being treated with propranolol who breastfeed their infant should inform their health care professional.
Propranolol prehaja v materino mleko, zato morajo matere, ki se zdravijo s propranololom in dojijo, o tem obvestiti svojega zdravnika.
Treatment with propranolol resulted in a rapid improvement (within 7-14 days) in all patients and resolution of the target haemangioma was observed in 36.4% of patients by 3 months.
Zdravljenje s propranololom je povzročilo hitro izboljšanje (v 7 do 14 dneh) pri vseh bolnikih, izginotje ciljnega hemangioma pa je bilo opaženo pri
Blood sugar decreases observed during clinical studies were asymptomatic.
Zmanjšanja koncentracije sladkorja v krvi, opažene med kliničnimi študijami, so bila asimptomatska.
• Citric acid monohydrate
• citronska kislina monohidrat
Nervous system disorders
Motnje živčnega sistema
• Bradycardia (abnormally low heart rate),
• bradikardija (neobičajno počasen srčni utrip),
• a local haemodynamic effect (vasoconstriction which is a classical consequence of beta adrenergic blockade and a decrease of infantile haemangioma lesion perfusion);
• lokalni hemodinamični učinek (vazokonstrikcija, ki je klasična posledica beta adrenergične blokade, in zmanjšanje prekrvitve lezije infantilnega hemangioma);
Propranolol may increase the risk of stroke in PHACE syndrome patients with severe cerebrovascular anomalies by dropping blood pressure and attenuating flow through occluded, narrow, or stenotic vessels.
Propranolol lahko poveča tveganje za možgansko kap pri bolnikih s sindromom PHACE s hudimi cerebrovaskularnimi nepravilnostmi zaradi znižanega krvnega tlaka in oslabitve pretoka skozi zamašene, zožene ali stenotične žile.
• Bronchiolitis (inflammation of small bronchi with breathing difficulties and wheeze in the chest,
• bronhiolitis (vnetje malih dihalnih poti (bronhiolov) s težavami z dihanjem in piskanjem v prsih,
• Bronchospasm (breathing difficulties),
• bronhospazem (težave z dihanjem),
Bradycardia should be diagnosed if the heart rate declines by more than 30 bpm from baseline.
Treba je postaviti diagnozo bradikardije, če srčni utrip odstopa za več kot 30 utripov na minuto od izhodiščnega.
Paediatric populations
Pediatrične populacije
Other medicines and HEMANGIOL
Druga zdravila in zdravilo HEMANGIOL
A haemangioma is a collection of extra blood vessels that have formed a lump in or under the skin.
Hemangiom je tvorba dodatnih krvnih žil, ki se oblikujejo v bulo v koži ali pod kožo.
• If your child has psoriasis (a skin condition that produces red, dry plaques of thickened skin), as this medicine may worsen the symptoms of this condition.
• če ima otrok psoriazo (luskavico - kožna bolezen, pri kateri nastajajo rdeče, suhe ploščice zadebeljene kože), saj to zdravilo poslabša simptome te bolezni.
1 What HEMANGIOL is and what it is used for What HEMANGIOL is
1 Kaj je zdravilo HEMANGIOL in za kaj ga uporabljamo Kaj je zdravilo HEMANGIOL
Peripheral coldness
Periferna hladnost
• The dose should always be measured using the oral syringe supplied with the bottle.
• Odmerek je vedno treba izmeriti s peroralno brizgo, ki je priložena steklenici z zdravilom.
1 bottle of 120 mL and 1 oral syringe.
peroralna raztopina 1 steklenica s 120 ml in 1 peroralna brizga
• an antiangiogenic effect (decrease of vascular endothelial cells proliferation, reduction of the neovascularization and formation of vascular tubules, reduction of the secretion of Matrix
• antiangiogenski učinek (zmanjšanje proliferacije vaskularnih endotelnih celic, zmanjšanje neovaskularizacije in tvorbe vaskularnih tubulov, zmanjšanje izločanja matriksne metaloproteinaze 9);
In the event of isolated bronchospasm, treatment must be permanently discontinued.
V primeru izoliranega bronhospazma je treba zdravljenje trajno prekiniti.
Stop treatment and contact your doctor immediately if after giving HEMANGIOL to your child you observe the following symptoms suggestive of a bronchospasm (temporary restriction of the bronchial tubes that leads to difficulty breathing): cough, quick or difficult breathing or wheezing, associated or not with a bluish-coloured skin.
Prenehajte z zdravljenjem in takoj obvestite zdravnika, če po uporabi zdravila HEMANGIOL pri otroku opazite naslednje simptome, ki kažejo na bronhospazem (začasna zožitev sapnic, ki povzroča težave z dihanjem): kašelj, hitro ali oteženo dihanje ali piskanje v pljučih, lahko (ne pa nujno) v povezavi z modrikasto kožo.
Wipe the outside dry.
Zunanjost obrišite do suhega.
• Heart conduction or rhythm disorders (slow or uneven heart beats),
• motnje prevodnosti srca ali srčnega ritma (počasen ali neenakomeren srčni utrip),
The therapeutic dose is 3 mg/kg/day, which is to be administered into 2 separate doses of 1.5 mg/kg, one in the morning and one in late afternoon, with a time interval of at least 9 hours between two intakes.
Terapevtski odmerek je 3 mg/kg/dan, ki ga je treba dajati v 2 ločenih odmerkih po 1,5 mg/kg, enega zjutraj in drugega pozno popoldan, med obema vnosoma pa mora miniti vsaj 9 ur.
Pack size: carton containing 1 bottle and 1 oral syringe.
Velikost pakiranja: škatla vsebuje 1 steklenico in 1 peroralno brizgo.
In particular, in case you are breastfeeding, tell your doctor or pharmacist if you are or if your child is taking:
Zlasti povejte zdravniku ali farmacevtu, če jemljete vi (v primeru dojenja) ali vaš otrok:
• Convulsions (fits) linked to hypoglycaemia (abnormally low blood sugar levels),
• krči, povezani s hipoglikemijo (neobičajno nizke revni sladkorja v krvi),
PIERRE FABRE DERMATOLOGIE 45 Place Abel Gance 92100 BOULOGNE FRANCE
PIERRE FABRE DERMATOLOGIE 45 Place Abel Gance 92100 BOULOGNE FRANCIJA
Infants with large facial infantile hemangioma should be thoroughly investigated for potential arteriopathy associated with PHACE syndrome, with magnetic resonance angiography of the head and neck and cardiac imaging to include the aortic arch, prior to considering propranolol therapy.
Dojenčke z velikim obraznim infantilnim hemangiomom je treba pred zdravljenjem s propranololom temeljito preiskati glede morebitne arteriopatije, povezane s sindromom PHACE, z magnetno resonančno angiografijo glave in vratu ter s slikanjem srca, ki vključuje aortni lok.
• has a heart problem (such as disorders of the heart rhythm and heart failure.
• srčne težave (npr. motnje srčnega ritma in srčno popuščanje).
• If your child has a PHACE syndrome (a condition combining haemangioma and vascular abnormalities including cerebral blood vessels), as this medicine may increase the risk of cerebral stroke.
• če ima vaš otrok sindrom PHACE (bolezen, ki vključuje hemangiom in žilne nepravilnosti, vključno s cerebralnimi krvnimi žilami), saj lahko to zdravilo poveča tveganje možganske kapi.
All beta-blocking agents can mask certain symptoms of hypoglycaemia: palpitations and tachycardia.
Vsi antagonisti adrenergičnih receptorjev beta lahko zakrijejo določene simptome hipoglikemije: palpitacije in tahikardijo.
Medicinal products inducing orthostatic hypotension Medicinal products that induce postural hypotension (nitrates derivatives, type 5-phosphodiesterase inhibitors, tricyclic antidepressants, antipsychotics, dopaminergic agonists, levodopa, amifostine, baclofen…) may add their effects to that of beta-blockers.
Zdravila, ki inducirajo posturalno hipotenzijo (nitratni derivati, zaviralci fosfodiesteraze tipa 5, triciklični antidepresivi, antipsihotiki, dopaminergični agonisti, levodopa, amifostin, baklofen...) lahko dodajo svoj učinek k učinku antagonistov adrenergičnih receptorjev beta.
In case of acute broncho-pulmonary abnormality, the initiation of the treatment should be postponed.
V primeru akutne bronhopulmonalne nepravilnosti je treba začetek zdravljenja odložiti.
With regard to centrally-acting antihypertensives, betablockers may exacerbate the rebound hypertension after clonidine abrupt withdrawal, and propranolol should be stopped several days before discontinuing clonidine.
Kar zadeva centralno delujoče antihipertenzive, antagonisti adrenergičnih receptorjev beta poslabšajo povratno hipertenzijo po nenadni prekinitvi jemanja klonidina, propranolol je zato treba prenehati jemati nekaj dni pred prenehanjem jemanja klonidina.
• The active substance is propranolol.
• Učinkovina je propranolol.
Their frequency is defined using the following conventions: very common (≥ 1/10), common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000); not known (cannot be estimated from the available data).
< 1/10); občasni (≥ 1/1.000 do < 1/100); redki (≥ 1/10.000 do < 1/1.000); zelo redki (< 1/10.000);
• The other ingredients are hydroxyethylcellulose, sodium saccharin, strawberry flavour (contains propylene glycol), vanilla flavour (contains propylene glycol), citric acid monohydrate, purified water.
• Druge sestavine zdravila so hidroksietilceluloza, natrijev saharin, aroma jagode (vsebuje propilenglikol), aroma vanilje (vsebuje propilenglikol), citronska kislina monohidrat, prečiščena voda.
Isoproterenol and aminophylline may be used for bronchospasm.
Za bronhospazem se lahko uporabljata izoproterenol in aminofilin.
Beta-blockers will result in an attenuation of reflex tachycardia and an increased risk of hypotension.
Antagonisti adrenergičnih receptorjev beta bodo povzročili atenuacijo refleksne tahikardije in povečano tveganje hipotenzije.
The regimen 3 mg/kg/day during 6 months (selected at the end of the phase II part of the study) presented 60.4% of success versus 3.6% in the placebo arm (p value < 0.0001).
faze študije) je bil uspešen v 60,4 % v primerjavi s 3,6-odstotnim uspehom pri placebu (vrednost p < 0,0001).
Dose by intake Timing of intakes
Odmerek na vnos Časovni razpored vnosov
In adult female rats, propranolol given into the uterus or by intravaginal administration is a powerful anti-implantation agent at dose ≥4 mg per animal, the effects being reversible.
Pri odraslih samicah podgan je propranolol, dan v maternico ali prek intravaginalnega dajanja, močno sredstvo proti implantaciji pri odmerku ≥4 mg na žival, učinki pa so reverzibilni.
• Medicines for diabetes,
• zdravila za sladkorno bolezen,
Check the HEMANGIOL dose in milligrams (mg) as prescribed by your doctor.
• 2. korak: Preverite odmerek Preverite odmerek zdravila HEMANGIOL v miligramih (mg), kot je predpisal zdravnik.
Bradycardia is defined below the following limits:
Bradikardija je definirana pod naslednjimi mejami: Starost
However, several reports of hypoglycaemia with related hypoglycaemic seizure were reported during the compassionate use program and in literature, especially in case of fasting period during intercurrent illness (see section
Vseeno pa so poročali o nekaj primerih hipoglikemije s povezanim hipoglikemičnim napadom med programom sočutne uporabe in v literaturi, zlasti v primeru obdobja posta med sočasno boleznijo