natgillin/translations-raw huggingface dataset:
• Stop blood clots from forming in your blood in the following situations: o When you have an acute illness and face period of limited mobility o When you have unstable angina (a condition when not enough blood gets to your heart)
o Če imate akutno bolezen in vas čaka obdobje omejene možnosti gibanja (mobilnosti) o Če imate nestabilno angino pektoris (motnjo, pri kateri v srce ne pride dovolj krvi)
At approximately 3 months following enrolment, the incidence of VTE remained significantly lower in the enoxaparin sodium 4,000 IU (40 mg) treatment group versus the placebo treatment group.
Približno 3 mesece po vključitvi je ostala incidenca VTE v terapevtski skupini s 4.000 i.e. (40 mg) natrijevega enoksaparinata značilno manjša kot v skupini s placebom.
An increase in exposure of enoxaparin sodium with prophylactic dosages (non-weight adjusted) has been observed in low-weight women (<45 kg) and low-weight men (<57 kg), which may lead to a higher risk of bleeding.
Pri bolnikih z majhno telesno maso (ženskah < 45 kg in moških < 57 kg) so med profilaktičnim odmerjanjem (neprilagojenim za telesno maso) opažali večjo izpostavljenost natrijevemu enoksaparinatu; to lahko poveča tveganje za krvavitve.
The dose of protamine depends on the dose of enoxaparin sodium injected; 1 mg protamine neutralizes the anticoagulant effect of 100 IU (1 mg) of enoxaparin sodium, if enoxaparin sodium was administered in the previous 8 hours.
Odmerek protamina je odvisen od odmerka injiciranega natrijevega enoksaparinata; če je bil natrijev enoksaparinat apliciran v zadnjih 8 urah, 1 mg protamina nevtralizira antikoagulantni učinek 100 i.e./kg (1 mg) natrijevega enoksaparinata.
To avoid the possible mixture of enoxaparin sodium with other drugs, the IV access chosen should be flushed with a sufficient amount of saline or dextrose solution prior to and following the IV bolus administration of enoxaparin sodium to clear the port of drug.
Da boste preprečili možno mešanje natrijevega enoksaparinata z drugimi zdravili, morate intravenski dostop sprati z zadostno količino fiziološke raztopine ali raztopine glukoze, in sicer pred dajanjem intravenskega bolusa natrijevega enoksaparinata in po njem, da boste nastavek očistili zdravila.
• Extended prophylaxis of VTE following orthopaedic surgery In a double blind study of extended prophylaxis for patients undergoing hip replacement surgery, 179 patients with no venous thromboembolic disease initially treated, while hospitalized, with enoxaparin sodium 4,000 IU (40 mg) SC, were randomized to a post-discharge regimen of either enoxaparin sodium 4,000 IU (40 mg) (n=90) once a day SC or to placebo (n=89) for 3 weeks.
• Podaljšana profilaksa VTE po ortopedskih operacijah V dvojno slepi študiji podaljšane profilakse pri bolnikih z operativno zamenjavo kolka so 179 bolnikov brez venske trombembolične bolezni, ki so bili med hospitalizacijo uvodoma zdravljeni z natrijevim enoksaparinatom 4.000 i.e. (40 mg) subkutano, po odpustu za 3 tedne randomizirali na shemo z natrijevim enoksaparinatom 4.000 i.e. (40 mg) subkutano enkrat na dan (n = 90) ali na placebo (n = 89).
Injection should be made preferably when the patient is lying down.
Zaželeno je, da bolnik med injiciranjem leži.
It is administered through the arterial line of a dialysis circuit for the prevention of thrombus formation in the extra corporeal circulation during haemodialysis.
Skozi arterijsko linijo se zdravilo v dializni obtok aplicira za preprečevanje nastanka krvnih strdkov v zunajtelesnem obtoku med hemodializo.
Retroperitoneal haemorrhage
Redki: Retroperitonealna
• Increased potassium in your blood.
• Zvišanje kalija v krvi.
• For treatment of acute STEMI, the recommended dose of enoxaparin sodium is a single intravenous (IV) bolus of 3,000 IU (30 mg) plus a 100 IU/kg (1 mg/kg) SC dose followed by 100 IU/kg (1 mg/kg) administered SC every 12 hours (maximum 10,000 IU (100 mg) for each of the first two SC doses).
• Za zdravljenje akutnega STEMI je priporočeni odmerek natrijevega enoksaparinata enkraten intravenski bolus 3.000 i.e. (30 mg) in 100 i.e./kg (1 mg/kg) subkutano, nato pa 100 i.e./kg (1 mg/kg) subkutano na 12 ur (največ 10.000 i.e. (100 mg) za vsakega od prvih dveh subkutanih odmerkov).
10,000 IU/mL (100 mg/mL) solution for injection
10.000 i.e./ml (100 mg/ml) raztopina za injiciranje
Prophylaxis of venous thromboembolism in medical patients The recommended dose of enoxaparin sodium is 4,000 IU (40 mg) once daily by SC injection.
Profilaksa venske trombembolije pri nekirurških bolnikih Priporočeni odmerek natrijevega enoksaparinata je 4.000 i.e. (40 mg) enkrat na dan v subkutani injekciji.
Enoxaparin sodium should be administered through an IV line.
Natrijev enoksaparinat je treba dati po intravenski liniji.
• SC injection technique:
• Postopek subkutanega injiciranja:
Therefore, it is recommended that the platelet counts be measured before the initiation of therapy with enoxaparin sodium and then regularly thereafter during the treatment.
Zato je pred začetkom zdravljenja z natrijevim enoksaparinatom in redno med zdravljenjem priporočljivo kontrolirati število trombocitov.
Retroperitoneal haemorrhage : such as haematoma, ecchymosis other than at injection site, wound haematoma, haematuria, epistaxis and gastro-intestinal haemorrhage.
Intrakranialna krvavitev, retroperitonealna krvavitev : npr. hematom, ekhimoze drugje kot na mestu injiciranja, hematom rane, hematurija, epistaksa in gastrointestinalna krvavitev.
To avoid bruising, do not rub the injection site after you have injected yourself.
Podplutbe preprečite, tako da mesta injiciranja po končanem injiciranju ne drgnete.
2,000 IU (20 mg) SC once daily
2.000 i.e. (20 mg) subkutano enkrat na dan
If you are breast-feeding or plan to breast-feed, you should ask your doctor for advice before taking this medicine.
Če dojite ali nameravate dojiti, se morate posvetovati z zdravnikom, preden vzamete to zdravilo.
In a second double-blind study, 262 patients without VTE disease and undergoing hip replacement surgery initially treated, while hospitalized, with enoxaparin sodium 4,000 IU (40 mg) SC were randomized to a post-discharge regimen of either enoxaparin sodium 4,000 IU (40 mg) (n=131) once a day SC or to placebo (n=131) for 3 weeks.
V drugi dvojno slepi študiji so 262 bolnikov brez venske trombembolične bolezni in z operativno zamenjavo kolka, ki so bili med hospitalizacijo uvodoma zdravljeni z natrijevim enoksaparinatom 4.000 i.e. (40 mg) subkutano, po odpustu za 3 tedne randomizirali na shemo z natrijevim enoksaparinatom 4.000 i.e. (40 mg) subkutano enkrat na dan (n = 131) ali na placebo (n = 131).
Make sure you hold the skin fold throughout the injection.
Kožno gubo morate držati ves čas injiciranja.
Do not expel the air bubble from the syringe before the injection to avoid the loss of drug when using prefilled syringes.
V primeru uporabe napolnjene injekcijske brizge iz nje pred injiciranjem ne poskušajte odstraniti zračnega mehurčka, da ne pride do izgube zdravila.
Overall, the data suggest that there is no evidence for an increased risk of haemorrhage, thrombocytopenia or osteoporosis with respect to the risk observed in non-pregnant women, other than that observed in pregnant women with prosthetic heart valves (see section 4.4).
Razen tveganja, opaženega pri nosečnicah s protetičnimi srčnimi zaklopkami, podatki v celoti pri nosečnicah ne kažejo večjega tveganja za krvavitve, trombocitopenijo ali osteoporozo v primerjavi s tveganjem, zabeleženim pri nenosečih ženskah (glejte poglavje 4.4).
• In patients at high risk of thromboembolism, the recommended dose of enoxaparin sodium is 4,000 IU (40 mg) once daily given by SC injection preferably started 12 hours before surgery.
• Če ima bolnik veliko tveganje za trombembolijo, je priporočeni odmerek natrijevega enoksaparinata 4.000 i.e. (40 mg) enkrat na dan v subkutani injekciji; uporaba naj se po možnosti začne 12 ur pred operacijo.
3) Choose an area on the right or left side of your stomach.
3) Izberite predel na desni ali levi strani trebuha, vsaj 5 cm od popka in v smeri proti bokom.
Prevention of thrombus formation during haemodialysis The recommended dose is 100 IU/kg (1 mg/kg) of enoxaparin sodium.
Preprečevanje nastanka krvnih strdkov med hemodializo Priporočeni odmerek je 100 i.e./kg (1 mg/kg) natrijevega enoksaparinata.
Enoxaparin sodium can be administered SC either as a once daily injection of 150 IU/kg (1.5 mg/kg) or as twice daily injections of 100 IU/kg (1 mg/kg).
Natrijev enoksaparinat je mogoče uporabiti v subkutani injekciji 150 i.e./kg (1,5 mg/kg) enkrat na dan ali v dveh injekcijah po 100 i.e./kg (1 mg/kg) na dan.
Intracranial haemorrhage, Retroperitoneal haemorrhage
Občasni: Intrakranialna retroperitonealna
Thorinane 10,000 IU (100 mg)/1.0 mL
Thorinane 10.000 i.e. (100 mg)/1,0 ml
Anti-Xa exposure represented by AUC, at steady-state, is marginally increased in mild (creatinine clearance 50-80 mL/min) and moderate (creatinine clearance 30-50 mL/min) renal impairment after repeated SC 4,000 IU (40 mg) once daily doses.
Izpostavljenost anti-Xa, kot jo kaže AUC, je po ponavljajoči se subkutani uporabi odmerkov 4.000 i.e. (40 mg) enkrat na dan pri blagi (očistek kreatinina 50-80 ml/min) in zmerni (očistek kreatinina 30-50 ml/min) okvari ledvic malenkostno povečana.
These events are rare with enoxaparin sodium dosage regimens 4,000 IU (40 mg) once daily or lower.
Ti učinki se redko pojavijo med uporabo natrijevega enoksaparinata v odmerku do 4.000 i.e. (40 mg) na dan ali manj.
Treatment of deep vein thrombosis with or without pulmonary embolism In a multicenter, parallel group study, 900 patients with acute lower extremity DVT with or without PE were randomized to an inpatient (hospital) treatment of either (i) enoxaparin sodium 150 IU/kg (1.5 mg/kg) once a day SC, (ii) enoxaparin sodium 100 IU/kg (1 mg/kg) every 12 hours SC, or (iii) heparin IV bolus (5,000 IU) followed by a continuous infusion (administered to achieve an aPTT of 55 to 85 seconds).
Zdravljenje globoke venske tromboze, s pljučno embolijo ali brez nje V multicentrični študiji vzporednih skupin so 900 bolnikov z akutno GVT spodnje okončine, s PE ali brez nje, randomizirali na bolnišnično zdravljenje (i) z natrijevim enoksaparinatom 150 i.e./kg (1,5 mg/kg) enkrat na dan subkutano, (ii) z natrijevim enoksaparinatom 100 i.e./kg (1 mg/kg) na 12 ur subkutano ali (iii) z intravenskim bolusom heparina (5.000 i.e.), ki mu je sledilo stalno infundiranje (uporabljeno tako, da je bil dosežen aPTČ od 55 do 85 sekund).
Enoxaparin sodium pharmacokinetics appears to be linear over the recommended dosage ranges.
Kaže, da je farmakokinetika natrijevega enoksaparinata v priporočenem odmernem območju linearna.
No pharmacokinetic interactions were observed between enoxaparin sodium and thrombolytics when administered concomitantly.
Med sočasno uporabljenim natrijevim enoksaparinatom in trombolitiki niso opazili farmakokinetičnih medsebojnih delovanj.
Common: Haemorrhage α
Pogosti: Krvavitev α
This could be because of a blood problem with low platelet counts.
Vzrok tega je lahko premajhno število trombocitov.
- Changing from blood thinners called vitamin-K antagonists (e.g. warfarin) to Thorinane Stop taking the vitamin-K antagonist.
- Prehod s sredstev za redčenje krvi, imenovanih antagonisti vitamina K (npr. varfarin) na zdravilo Thorinane
100 IU/kg (1 mg/kg) body weight SC once daily
100 i.e. (1 mg/kg) telesne mase subkutano enkrat na dan
Volume to be injected through IV line after dilution is completed at a concentration of 300 IU (3 mg) /mL.
Količina, ki jo je treba injicirati v intravensko linijo po dokončanem razredčenju na koncentracijo 300 i.e. (3 mg)/ml.
• Bleeding.
• Krvavitve
Enoxaparin sodium was found to have no effect on fertility or reproductive performance of male and female rats at SC doses up to 20 mg/kg/day.
Ugotovljeno je bilo, da natrijev enoksaparinat v subkutanih odmerkih do 20 mg/kg/dan ne vpliva na plodnost ali sposobnost razmnoževanja podganjih samcev in samic.
• Hard mass or lump at the injection site.
• Trda gmota ali bula na mestu injiciranja.
IU
Celotno
In the clinical studies for treatment of unstable angina and non-Q-wave myocardial infarction, doses were 100 IU/kg (1 mg/kg) SC every 12 hours, and in the clinical study for treatment of acute STEMI enoxaparin sodium regimen was a 3,000 IU (30 mg) IV bolus followed by 100 IU/kg (1 mg/kg) SC every 12 hours.
V kliničnih študijah za zdravljenje nestabilne angine pektoris in miokardnega infarkta brez zobca Q so bili odmerki 100 i.e./kg (1 mg/kg) subkutano na 12 ur, v klinični študij za zdravljenje akutnega STEMI pa je bila shema natrijevega enoksaparinata 3.000 i.e. (30 mg) v intravenskem bolusu, ki mu je sledila uporaba 100 i.e./kg (1 mg/kg) subkutano na 12 ur.
• The usual dose is 100 IU (1 mg) for every kilogram of your weight.
• Običajen odmerek je 100 i.e. (1 mg) na kilogram telesne mase.
• you have diabetes or problems with blood vessels in the eye caused by diabetes (called diabetic
• če imate sladkorno bolezen ali imate zaradi sladkorne bolezni težave z žilami v očeh (to
Enoxaparin sodium 150 IU/kg (1.5 mg/kg) once a day SC n (%)
Natrijev enoksaparinat 150 i.e./kg (1,5 mg/kg) enkrat na dan subkutano n (%)
The mean maximum anti-IIa activity level is observed approximately 3 to 4 hours following SC injection and reaches 0.13 IU/mL and 0.19 IU/mL following repeated administration of 100 IU/kg (1 mg/kg) twice daily and 150 IU/kg (1.5 mg/kg) once daily, respectively.
Povprečna največja raven aktivnosti anti-IIa se pojavi približno 3 do 4 ure po subkutanem injiciranju in doseže po večkratni uporabi 100 i.e./kg (1 mg/kg) dvakrat na dan 0,13 i.e./ml in po uporabi 150 i.e./kg (1,5 mg/kg) enkrat na dan 0,19 i.e./ml.
Stopping blood clots forming in your blood in the following situations: Operation or periods of limited mobility due to an illness
Ob operacijah ali obdobjih omejene mobilnosti zaradi bolezni
The occurrence of total and major bleeding were respectively 8.6% and 1.1% in the placebo group, 11.7% and 0.3% in the enoxaparin sodium 2,000 IU (20 mg) group and 12.6% and 1.7% in the enoxaparin sodium 4,000 IU (40 mg) group.
Pojavljanje vseh krvavitev je bilo v skupini s placebom 8,6 %, v skupini z 2.000 i.e. (20 mg) natrijevega enoksaparinata 11,7 % in v skupini s 4.000 i.e. (40 mg) natrijevega enoksaparinata 12,6 %, večjih krvavitev pa v prvi 1,1 %, v drugi 0,3 % in v tretji 1,7 %.
• Prevention of thrombus formation in extra corporeal circulation during haemodialysis.
• Preprečevanje nastanka krvnih strdkov v zunajtelesnem obtoku med hemodializo.
When given at a dose of 4,000 IU (40 mg) once a day SC, enoxaparin sodium significantly reduced the incidence of VTE as compared to placebo.
Natrijev enoksaparinat v odmerku 4.000 i.e. (40 mg) enkrat na dan subkutano je zmanjšal incidenco VTE značilno bolj kot placebo.
Enoxaparin sodium 100 IU/kg (1 mg/kg) twice a day SC n (%)
Natrijev enoksaparinat 100 i.e./kg (1 mg/kg) dvakrat na dan subkutano n (%)
• Thorinane can be added to the tube leaving the body (arterial line) at the start of the dialysis session.
• Zdravilo Thorinane se lahko na začetku dialize da v cevko, ki vodi iz telesa (v arterijsko linijo).
Driving and using machines Thorinane does not affect the ability to drive and operate machinery.
Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Thorinane ne vpliva na sposobnost upravljanja vozil in strojev.
There have been cases of neuraxial haematomas reported with the concurrent use of enoxaparin sodium and spinal/epidural anaesthesia or spinal puncture procedures resulting in long term or permanent paralysis.
Med sočasno uporabo natrijevega enoksaparinata in spinalne/epiduralne anestezije ali spinalne punkcije so bili opisani nevraksialni hematomi, ki so povzročili dolgotrajno ali trajno paralizo.
All Treated DVT Patients with or without PE Total VTE (%)
Vsi zdravljeni bolniki z GVT, s PE ali brez nje
*The 95% Confidence Intervals for the treatment differences for total VTE were: - enoxaparin sodium once a day versus heparin (-3.0 to 3.5)
VTE = venski trombembolični dogodek (GVT in/ali PE) *95-odstotna intervala zaupanja za razliko med zdravljenji za vse VTE sta bila: - natrijev enoksaparinat enkrat na dan v primerjavi s heparinom (-3,0 do 3,5) - natrijev enoksaparinat na 12 ur v primerjavi s heparinom (-4,2 do 1,7)
1) Stopping existing blood clots from getting any bigger.
1) Zavira nadaljnjo rast obstoječih krvnih strdkov.
There have been isolated post-marketing reports of valve thrombosis in pregnant women with mechanical prosthetic heart valves while receiving enoxaparin sodium for thromboprophylaxis.
Po prihodu zdravila na trg so bili opisani posamezni primeri tromboze zaklopke pri nosečnicah z mehaničnimi protetičnimi srčnimi zaklopkami, ki so za tromboprofilakso dobivale natrijev enoksaparinat.
All Treated Medical Patients During Acute Illness Total VTE (%)
Vsi zdravljeni nekirurški bolniki med akutno boleznijo
A puncture-free interval of at least 24 hours shall be kept between the last injection of enoxaparin sodium at curative doses and the needle or catheter placement (see also section 4.3).
- V odmerkih, ki se uporabljajo za zdravljenje Med zadnjo injekcijo natrijevega enoksaparinata v kurativnih odmerkih in vstavitvijo igle ali katetra mora miniti vsaj 24 ur brez punkcij (glejte tudi poglavje 4.3).
Thorinane 2,000 IU (20 mg)/0.2 mL
Thorinane 2.000 i.e. (20 mg)/0,2 ml
Do not press on the plunger before injecting yourself to get rid of air bubbles.
Ne pritiskajte bata pred injiciranjem, da bi iztisnili zračne mehurčke, saj lahko izgubite nekaj zdravila.
Enoxaparin sodium 4,000 IU (40 mg) once a day SC n (%)
Natrijev enoksaparinat 4.000 i.e. (40 mg) enkrat na dan subkutano n (%)
A puncture-free interval of at least 12 hours shall be kept between the last injection of enoxaparin sodium at prophylactic doses and the needle or catheter placement.
- V odmerkih, ki se uporabljajo za profilakso Med zadnjo injekcijo natrijevega enoksaparinata v profilaktičnih odmerkih in vstavitvijo igle ali katetra mora miniti vsaj 12 ur brez punkcij.
• Hair loss.
• Izpadanje las.
Treatment of acute ST-segment elevation myocardial infarction In a large multicenter study, 20,479 patients with STEMI eligible to receive fibrinolytic therapy were randomized to receive either enoxaparin sodium in a single 3,000 IU (30 mg) IV bolus plus a 100 IU/kg (1 mg/kg) SC dose followed by an SC injection of 100 IU/kg (1 mg/kg) every 12 hours or IV unfractionated heparin adjusted based on aPTT for 48 hours.
Zdravljenje akutnega miokardnega infarkta z dvigom spojnice ST V veliki multicentrični študiji so 20.479 bolnikov s STEMI, primernih za fibrinolitično zdravljenje, za 48 ur randomizirali ali na natrijev enoksaparinat v enkratnem intravenskem bolusu 3.000 i.e. (30 mg) ter 100 i.e./kg (1 mg/kg) subkutano, čemur je sledilo subkutano injiciranje 100 i.e./kg (1 mg/kg) na 12 ur ali na nefrakcionirani heparin intravensko glede na aPTČ.
Thorinane 8,000 IU (80 mg)/0.8 mL
Thorinane 8.000 i.e. (80 mg)/0,8 ml
NSTEMI type of heart attack:
Srčni infarkt vrste NSTEMI
ATC code: B01A B05
5.1 Farmakodinamične lastnosti Farmakoterapevtska skupina: antitrombotiki, heparinska skupina, oznaka ATC: B01A B05
The mean maximum plasma anti-Xa activity level is observed 3 to 5 hours after SC injection and achieves approximately 0.2, 0.4, 1.0 and 1.3 anti-Xa IU/mL following single SC administration of 2,000 IU, 4,000 IU, 100 IU/kg and 150 IU/kg (20 mg, 40 mg, 1 mg/kg and 1.5 mg/kg) doses, respectively.
Povprečna največja aktivnost anti-Xa v plazmi se pojavi od 3 do 5 ur po subkutanem injiciranju in doseže po enkratni subkutani uporabi 2.000 i.e. (20 mg) približno 0,2 anti-Xa i.e./ml, po 4.000 i.e. (40 mg) približno 0,4 anti-Xa i.e./ml, po 100 i.e./kg (1 mg/kg) približno 1,0 anti-Xa i.e./ml in po 150 i.e./kg (1,5 mg/kg) približno 1,3 anti-Xa i.e./ml.
1 x 3,000 IU (30 mg) IV bolus plus 100 IU/kg (1 mg/kg) body weight SC and then 100 IU/kg (1 mg/kg) body weight SC every 24 hours
1 x intravenski bolus 3.000 i.e. (30 mg) in obenem 100 i.e./kg (1 mg/kg) telesne mase subkutano, nato 100 i.e./kg (1 mg/kg) telesne mase subkutano na 24 ur
• Mechanical prosthetic heart valves
• Mehanične protetične srčne zaklopke
• Rare: Cholestatic liver injury*
• Redki: Holestatska okvara jeter*
• Skin necrosis / cutaneous vasculitis
• Nekroza kože/kožni vaskulitis
• Thorinane is added to the tube leaving the body (arterial line) at the start of the dialysis session.
• Zdravilo Thorinane se na začetku dialize da v cevko, ki vodi iz telesa (v arterijsko linijo).
• Proximal DVT (%)
Proksimalne GVT (%)
The usual dose is 100 IU (1 mg) for every kilogram of your weight, every 12 hours.
Običajen odmerek je 100 i.e. (1 mg) na kilogram telesne mase na 12 ur.
• you are going to receive spinal or epidural anesthesia or lumbar puncture (see Operations and
• če boste prejeli spinalno ali epiduralno anestezijo ali lumbalno punkcijo (glejte Operacije in anestezija): upoštevati je treba zakasnitev med uporabo zdravila Thorinane in tem postopkom.
• Renal impairment
• Okvara ledvic
o For patients with a high venous thromboembolism (VTE) risk who undergo abdominal or pelvic surgery for cancer an extended thromboprophylaxis up to 4 weeks is
o Pri bolnikih z večjo ortopedsko operacijo je priporočljiva podaljšana o Pri bolnikih z velikim tveganjem za vensko trombembolijo (VTE) s trebušno ali medenično operacijo zaradi raka je priporočljiva podaljšana tromboprofilaksa do 4
• The usual dose is 100 IU (1 mg) for every kilogram of weight every 12 hours.
• Običajen odmerek je 100 i.e. (1 mg) na kilogram telesne mase na 12 ur.
Immuno-allergic thrombocytopeni a
Imuno-alergijska trombocitopenija
• Severe renal impairment
• Huda okvara ledvic
Enoxaparin sodium 2,000 IU (20 mg) once a day SC n (%)
Natrijev enoksaparinat 2.000 i.e. (20 mg) enkrat na dan subkutano n (%)
• Common: Injection site haematoma, injection site pain, other injection site reaction (such as oedema,
• Pogosti: Hematom na mestu injiciranja, bolečina na mestu injiciranja, druge reakcije na mestu injiciranja (na primer edem, krvavitev, preobčutljivost, vnetje, masa, bolečina ali reakcija)
How to store Thorinane
Kako si injicirate zdravilo Thorinane
No IV initial bolus, 100 IU/kg (1 mg/kg) body weight SC and then 100 IU/kg (1 mg/kg) body weight SC every 24 hours
Brez začetnega intravenskega bolusa 100 i.e./kg (1 mg/kg) telesne mase subkutano, nato 100 i.e./kg (1 mg/kg) telesne mase subkutano na 24 ur
Treatment of unstable angina and non ST elevation myocardial infarction In a large multicenter study, 3,171 patients enrolled at the acute phase of unstable angina or non-Q-wave myocardial infarction were randomized to receive in association with acetylsalicylic acid (100 to 325 mg once daily), either SC enoxaparin sodium 100 IU/kg (1 mg/kg) every 12 hours or IV unfractionated heparin adjusted based on aPTT.
Zdravljenje nestabilne angine pektoris in miokardnega infarkta brez dviga spojnice ST V veliki multicentrični študiji so 3.171 bolnikov, vključenih v akutni fazi nestabilne angine pektoris ali miokardnega infarkta brez zobca Q, randomizirali na prejemanje natrijevega enoksaparinata 100 i.e./kg (1 mg/kg) subkutano na 12 ur ali nefrakcioniranega heparina intravensko s prilagoditvijo glede na aPTČ.
• For acute STEMI, treatment is to be initiated with a single IV bolus injection immediately followed by a
• Intravensko (bolusno) injiciranje (samo za indikacijo akutni STEMI): Zdravljenje akutnega STEMI je treba začeti z eno intravensko bolusno injekcijo, ki ji neposredno sledi subkutana injekcija.
• Skin rash (hives, urticaria).
• Izpuščaj na koži (koprivnica)
The 2 hours preoperative initiation of enoxaparin sodium 2,000 IU (20 mg) is not compatible with neuraxial anaesthesia.
Dvourna predoperacijska uvedba 2.000 i.e. (20 mg) natrijevega enoksaparinata ni združljiva z
One pre-filled syringe (0.2 mL) contains 2,000 IU (20 mg) enoxaparin sodium
Ena napolnjena injekcijska brizga (0,2 ml) vsebuje 2.000 i.e. (20 mg) natrijevega enoksaparinata
No difference in major bleeding was found between the enoxaparin sodium and the placebo group.
Med natrijevim enoksaparinatom in placebom niso ugotovili razlik v večjih krvavitvah.
SC injection Do not mix with other products.
Subkutano injiciranje Zdravila Thorinane ne smete mešati z drugimi injekcijami ali infuzijami.