natgillin/translations-raw huggingface dataset:
Usually, the side effects will slowly go away as your body gets used to the medicine.
Navadno ti neželeni učinki počasi izginejo, najverjetneje zato, ker se telo zdravila navadi.
They are packed in blisters available in three different pack sizes (28, 56 or 112 capsules) and plastic bottles of 250 capsules, but these may not all be available in your country.
112 kapsul) in v plastičnih steklenicah s po 250 kapsulami, vendar morda v vaši državi niso na voljo vsa navedena pakiranja.
Similarly a larger treatment effect was observed in those patients with visual hallucinations (see Table 6).
Prav tako so boljši učinek opazili pri tistih bolnikih, ki so imeli vidne halucinacije (glejte preglednico 6).
Like other cholinomimetics, rivastigmine may exacerbate or induce extrapyramidal symptoms.
Podobno kot drugi holinomimetiki lahko rivastigmin povzroči poslabšanje ali pojav ekstrapiramidnih simptomov.
Patients with dementia and Parkinson's disease
Bolniki z demenco in Parkinsonovo boleznijo
Caution is advised in patients at higher risk of developing torsade de pointes; for example, those with uncompensated heart failure, recent myocardial infarction, bradyarrhythmias, a predisposition to hypokalaemia or hypomagnesaemia, or concomitant use with medicinal products known to induce QT prolongation and/or torsade de pointes (see sections 4.5 and 4.8).
Potrebna je previdnost pri bolnikih z večjim tveganjem za pojav torsade de pointes; na primer pri tistih, ki imajo nekompenzirano srčno popuščanje, nedaven miokardni infarkt, bradiaritmije, bolnikih, ki so nagnjeni k hipokaliemiji ali hipomagneziemiji ali sočasno uporabljajo zdravila, za katera je znano, da povzročajo podaljšanje intervala QT in/ali torsade de pointes (glejte poglavji 4.5 in 4.8).
Table 2 shows the adverse reactions reported during clinical studies conducted in patients with dementia associated with Parkinson's disease treated with rivastigmine capsules.
Preglednica 2 prikazuje neželene učinke, o katerih so poročali iz kliničnih študij, ki so jih izvajali pri bolnikih z demenco, povezano s Parkinsonovo boleznijo, zdravljenih s kapsulami zdravila Rivastigmin.
- if you have had a previous skin reaction suggestive of allergic contact dermatitis with rivastigmine.
- če ste imeli v preteklosti pri uporabi rivastigmina kožno reakcijo, ki kaže na alergijski kontaktni dermatitis.
• Aggression, feeling restless
• agresivnost, občutek nemira
The secondary definition of response required a 4-point or greater improvement on the ADAS-Cog, no worsening on the CIBIC-Plus, and no worsening on the PDS.
Sekundarna opredelitev odziva je zahtevala izboljšanje pri ADAS-Cog za najmanj 4 točke in nobenega poslabšanja pri CIBIC-Plus ter PDS.
Rivastigmine HEXAL 1.5 mg hard capsules Rivastigmine HEXAL 3 mg hard capsules Rivastigmine HEXAL 4.5 mg hard capsules Rivastigmine HEXAL 6 mg hard capsules
Rivastigmin HEXAL 1,5 mg trde kapsule Rivastigmin HEXAL 3 mg trde kapsule Rivastigmin HEXAL 4,5 mg trde kapsule Rivastigmin HEXAL 6 mg trde kapsule
The capsules and oral solution can also be used for the treatment of dementia in adult patients with Parkinson's disease.
Kapsule in peroralna raztopina se lahko uporabljajo tudi za zdravljenje demence pri odraslih bolnikih s Parkinsonovo boleznijo.
How to store Rivastigmine HEXAL Contents of the pack and other information
Shranjevanje zdravila Rivastigmin HEXAL Vsebina pakiranja in dodatne informacije
Taking the two medicines together could cause problems such as stiff limbs and trembling hands.
Sočasna uporaba teh dveh zdravil lahko povzroči težave, kot so okorelost okončin in tresenje rok.
• Too much saliva and dehydration
• čezmerno slinjenje in dehidracija
The patients studied had an MMSE (Mini-Mental State Examination) score of 10-24.
Proučevani bolniki so imeli rezultate MMSE (Mini-Mental State Examination - kratek preizkus spoznavnih sposobnosti) med 10 in 24.
2 Mean data shown for convenience, categorical analysis performed using van Elteren test
2 Zaradi prikladnosti so prikazani povprečni podatki, analiza po kategorijah je opravljena z van
After using the syringe
Po uporabi injekcijske brizge
During therapy patient's weight should be monitored.
Med zdravljenjem moramo spremljati bolnikovo telesno maso.
If you take more Rivastigmine HEXAL than you should
Če ste vzeli večji odmerek zdravila Rivastigmin HEXAL, kot bi smeli
If you get any of these side effects, contact your doctor as you may need medical assistance.
Če se pojavijo takšni neželeni učinki, obvestite svojega zdravnika, ker boste morda potrebovali zdravniško pomoč.
• Liver disorders (yellow skin, yellowing of the whites of the eyes, abnormal darkening of the urine or unexplained nausea, vomiting, tiredness and loss of appetite)
• jetrne motnje (porumenelost kože, porumenelost očesnih beločnic, nenormalno temen urin ali nepojasnjena slabost v želodcu, bruhanje, utrujenost in izguba apetita)
No pharmacokinetic interaction was observed between rivastigmine and digoxin, warfarin, diazepam or fluoxetine in studies in healthy volunteers.
Med rivastigminom in digoksinom, varfarinom, diazepamom ali fluoksetinom v študijah na zdravih prostovoljcih niso opazili farmakokinetičnega medsebojnega delovanja.
However, a greater treatment effect was seen in Parkinson's disease patients with moderate dementia.
Vendar pa so boljši terapevtski učinek opazili pri tistih bolnikih s Parkinsonovo boleznijo, ki so imeli zmerno demenco.
Total patients studied Total patients with pre-defined AE(s) Tremor
Vsi bolniki z neželenimi dogodki (AE - “adverse event”) Tremor
Patients with clinically significant renal or hepatic impairment might experience more adverse reactions (see sections 4.2 and 5.2).
Pri bolnikih s klinično pomembno okvaro ledvic ali jeter je lahko število neželenih učinkov večje (glejte poglavji 4.2 in 5.2).
Dosing recommendations to titrate according to individual tolerability must be closely followed.
Morate se natančno ravnati po priporočilih za titriranje odmerjanja glede na individualno prenašanje.
- HDPE bottles with plastic closure with induction inner seal.
- Steklenice iz HDPE s plastično zaporko z zaščitno folijo.
Cholinergic toxicity has been reported with muscarinic symptoms that are observed with moderate poisonings such as miosis, flushing, digestive disorders including abdominal pain, nausea, vomiting and diarrhoea, bradycardia, bronchospasm and increased bronchial secretions, hyperhidrosis, involuntary urination and/or defecation, lacrimation, hypotension and salivary hypersecretion.
Poročali so o holinergični toksičnosti z muskarinskimi simptomi, ki se opažajo pri zmernih zastrupitvah, kot so mioza, navali vročine, prebavne motnje, vključno s trebušnimi bolečinami, siljenjem na bruhanje, bruhanjem in drisko, bradikardija, bronhospazem in povečanje bronhijskih izločkov, hiperhidroza, nehotno uriniranje in/ali defekacija, solzenje, hipotenzija in čezmerno izločanje sline.
Efficacy has been established by the use of two independent scales which were assessed at regular intervals during a 6-month treatment period as shown in Table 5 below: the ADAS-Cog, a measure of cognition, and the global measure ADCS-CGIC (Alzheimer's Disease Cooperative Study-Clinician's Global Impression of Change).
6-mesečnim obdobjem zdravljenja, kot kaže preglednica 5 spodaj: ADAS-Cog, merilo za kognicijo, in globalno merilo ADCS-CGIC (Alzheimer's Disease Cooperative Study-Clinician's Global Impression of Change /Kooperativna študija Alzheimerjeve bolezni-globalni klinični vtis sprememb).
Caution when Rivastigmine HEXAL is taken together with beta-blockers (medicines such as atenolol used to treat hypertension, angina and other heart conditions).
Previdnost je potrebna, kadar jemljete zdravilo Rivastigmin HEXAL skupaj z zaviralci receptorjev beta (zdravila, kot so atenolol za zdravljenje hipertenzije, angine pektoris in drugih srčnih bolezni).
Other medicines and Rivastigmine HEXAL
Druga zdravila in zdravilo Rivastigmin HEXAL
• The signs of Parkinson's disease get worse or getting similar signs - such as stiff muscles,
• poslabšanje znakov Parkinsonove bolezni ali pojav podobnih znakov - na primer togih mišic ali težav pri izvajanju gibov
No evidence of carcinogenicity was found in studies in mice and rats at the maximum tolerated dose, although the exposure to rivastigmine and its metabolites was lower than the human exposure.
V raziskavah na miših in podganah pri največjem odmerku, ki so ga živali še prenašale, niso opazili nobenih znakov kancerogenosti; vendar je bila izpostavljenost rivastigminu in njegovim presnovkom manjša od izpostavljenosti pri ljudeh.
• Wipe the outside of the syringe with a clean tissue.
• Zunanjost injekcijske brizge obrišite s čistim robčkom.
Previous history of application site reactions suggestive of allergic contact dermatitis with rivastigmine patch (see section 4.4).
Reakcije na mestu apliciranja, ki bi bile lahko znak alergijskega kontaktnega dermatitisa pri uporabi transdermalnih obližev z rivastigminom, v anamnezi (glejte poglavje 4.4).
Rivastigmine works by blocking the enzymes that break down acetylcholine: acetylcholinesterase and butyrylcholinesterase.
Rivastigmin deluje tako, da blokira dva encima, ki razgrajujeta acetilholin, to sta acetilholin-esteraza in butirilholin-esteraza.
How to use this medicine
Kako uporabljati zdravilo
The Cmax of rivastigmine was approximately 60% higher and the AUC of rivastigmine was more than twice as high in subjects with mild to moderate hepatic impairment than in healthy subjects.
Cmax rivastigmina je bila za približno 60 % večja in AUC rivastigmina več kot dvakrat večja pri osebah z blago do zmerno jetrno okvaro kot pri zdravih osebah.
• Problems with your heartbeat such as fast or slow heartbeat
• motnje srčnega ritma, kot sta prepočasen ali prehiter srčni utrip
Clinical monitoring is recommended for these adverse reactions.
Ob takih neželenih učinkih je priporočljivo klinično spremljanje.
• Then, put the syringe back in its protective case.
• Nato brizgo spravite nazaj v varovalni tulec.
There have been rare post-marketing reports of patients experiencing allergic dermatitis (disseminated) when administered rivastigmine irrespective of the route of administration (oral, transdermal).
V redkih poročilih iz obdobja po prihodu zdravila na trg so opisovali bolnike, pri katerih je pri aplikaciji rivastigmina prišlo do (diseminiranega) alergijskega dermatitisa ne glede na način vnosa zdravila (peroralno ali transdermalno).
Store in an upright position.
Shranjujte v pokončnem položaju.
Skin application site reactions may occur with rivastigmine patch and are usually mild or moderate in intensity.
Pri uporabi transdermalnih obližev z rivastigminom se lahko pojavijo kožne reakcije na mestu apliciranja, ki običajno imajo blago ali zmerno intenzivnost.
• Swallow your medicine straight from the syringe.
• Zdravilo zaužijte neposredno iz injekcijske brizge.
While bioavailability of rivastigmine is greater in elderly than in young healthy volunteers, studies in Alzheimer patients aged between 50 and 92 years showed no change in bioavailability with age.
študije pri bolnikih z Alzheimerjevo boleznijo, starih od 50 do 92 let, niso pokazale, da bi se biološka uporabnost s starostjo spreminjala.
Thus, rivastigmine may have an ameliorative effect on cholinergic-mediated cognitive deficits in dementia associated with Alzheimer's disease and Parkinson's disease.
Zato bi rivastigmin lahko izboljšal stanje holinergično posredovanega upada kognitivnih funkcij pri demenci, povezani z Alzheimerjevo boleznijo in s Parkinsonovo boleznijo.
Cholinesterase inhibitors should be prescribed with care to patients with a history of asthma or obstructive pulmonary disease.
Pri predpisovanju zaviralcev holinesteraze bolnikom z anamnezo astme ali obstruktivne pljučne bolezni je potrebna previdnost.
Rivastigmine HEXAL oral solution is supplied as 50 ml or 120 ml of a clear, yellow solution (2.0 mg/ml base) in an amber glass bottle with a child-resistant cap, foam liner, dip tube and self aligning plug.
Peroralna raztopina Rivastigmin HEXAL je na voljo v obliki 50 ml ali 120 ml bistre rumene raztopine (2 mg/ml baze), v jantarno obarvani steklenici z za otroke varno zaporko, oblogo iz penaste gume, s kapalnim vložkom in s prilegajočim se zamaškom.
- The other ingredients are: hypromellose, magnesium stearate, microcrystalline cellulose, colloidal anhydrous silica, gelatin, yellow iron oxide red iron oxide, titanium dioxide, and shellac.
- Pomožne snovi so hipromeloza, magnezijev stearat, mikrokristalna celuloza, koloidni brezvodni silicijev dioksid, želatina, rumeni železov oksid, rdeči železov oksid, titanov dioksid in šelak.
Taking the two medicines together could cause problems such as slowing of the heartbeat (bradycardia) leading to fainting or loss of consciousness.
Sočasna uporaba teh dveh zdravil lahko povzroči težave, kot so upočasnjen srčni utrip (bradikardija),
Patients with severe hepatic impairment have not been studied, however, rivastigmine capsules may be used in this patient population provided close monitoring is exercised (see sections 4.4 and 5.2).
Uporabe zdravila pri bolnikih s težko jetrno okvaro niso proučili, vendar se kapsule rivastigmina lahko uporabljajo pri tej populaciji bolnikov, če se izvaja natančno spremljanje (glejte poglavji 4.4 in 5.2).
Female patients in clinical studies were found to be more susceptible than male patients to gastrointestinal adverse reactions and weight loss.
Bolnice v kliničnih študijah so bile dovzetnejše za gastrointestinalne neželene učinke in za hujšanje kot bolniki.
Other side effects seen with transdermal patches and which may occur with the oral solution:
Drugi neželeni učinki, ki so jih opazili pri transdermalnih obližih in bi se lahko pojavili tudi pri uporabi peroralne raztopine:
Therefore, caution should be exercised when rivastigmine is combined with beta-blockers and also other bradycardia agents (e.g.class III antiarrhythmic agents, calcium channel antagonists, digitalis glycoside, pilocarpin).
Zato je treba previdno ravnati pri uporabi rivastigmina v kombinaciji z zaviralci receptorjev beta in drugimi zdravili proti bradikardiji (npr. antiaritmikih iz skupine III, antagonisti kalcijevih kanalčkov, digitalisovi glikozidi, pilokarpin).
Furthermore, rivastigmine can induce dizziness and somnolence, mainly when initiating treatment or increasing the dose.
Nadalje lahko rivastigmin povzroči vrtoglavost in somnolenco, predvsem na začetku zdravljenja ali ob povečanju odmerka.
Additionally there have been post-marketing cases of dizziness, tremor, headache, somnolence, confusional state, hypertension, hallucinations and malaise.
V obdobju trženja zdravila so dodatno ugotovili primere omotice, tremorja, glavobola, somnolence, zmedenosti, hipertenzije, halucinacij in slabosti.
50 ml oral solution 120 ml oral solution
50 ml peroralna raztopina 120 ml peroralna raztopina
By blocking these enzymes, Rivastigmine HEXAL allows levels of acetylcholine to be increased in the brain, helping to reduce the symptoms of Alzheimer's disease and dementia associated with Parkinson's disease.
Zdravilo Rivastigmin HEXAL z blokiranjem navedenih encimov omogoča zvišanje koncentracije acetilholina v možganih in s tem pomaga pri zmanjševanju simptomov Alzheimerjeve bolezni in demence, v povezavi s Parkinsonovo boleznijo.
• Accidentally falling
• nezgodni padec
Care should be exercised in treating patients with active gastric or duodenal ulcers or patients predisposed to these conditions.
Pri zdravljenju bolnikov z aktivnimi razjedami želodca ali dvanajstnika ali bolnikov z nagnjenostjo k tem boleznim je potrebna previdnost.
Pharmacotherapeutic group: psychoanaleptics, anticholinesterases, ATC code: N06DA03 Rivastigmine is an acetyl- and butyrylcholinesterase inhibitor of the carbamate type, thought to facilitate cholinergic neurotransmission by slowing the degradation of acetylcholine released by functionally intact cholinergic neurones.
Farmakoterapevtska skupina: psihoanaleptiki, antiholinesteraze, oznaka ATC: N06DA03 Rivastigmin je zaviralec acetilholinesteraze in butirilholinesteraze karbamatne vrste, za katerega velja,
The prescribed amount of solution should be withdrawn from the bottle using the oral dosing syringe supplied.
Predpisano količino raztopine je treba vzeti iz steklenice s priloženo brizgo za peroralno odmerjanje.
Initial dose 1.5 mg twice a day.
1,5 mg dvakrat na dan.
Subsequent increases to 4.5 mg and then 6 mg twice a day should also be based on good tolerability of the current dose and may be considered after a minimum of two weeks of treatment at that dose level.
Če bolnik ta odmerek po najmanj dveh tednih zdravljenja dobro prenaša, lahko odmerek povečamo na 3 mg dvakrat na dan. Tudi poznejše povečanje odmerka na 4,5 mg in nato na 6 mg dvakrat na dan mora temeljiti na dobrem prenašanju trenutnega odmerka in lahko pride v poštev po najmanj dveh tednih zdravljenja s tem odmerkom.
Taking your medicine
Jemanje zdravila
PARTICULARS TO APPEAR ON THE OUTER PACKAGING CARTON FOR ALU/PVC BLISTER
PODATKI NA ZUNANJI OVOJNINI ŠKATLA ZA PRETISNI OMOT IZ ALU/PVC
• Swallow the capsules whole with a drink.
• Kapsule pogoltnite cele z nekaj tekočine.
- if you have, or have ever had, difficulties in passing urine.
- če imate ali ste imeli težave z uriniranjem,
In pregnant animals, rivastigmine and/or metabolites crossed the placenta.
Pri brejih živalih rivastigmin in/ali presnovki prehajajo skozi posteljico.
D. CONDITIONS OR RESTRICTIONS WITH REGARDS TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
D. POGOJI ALI OMEJITVE V ZVEZI Z VARNO IN UČINKOVITO UPORABO
- Capsule fill: - Microcrystaline cellulose - Magnesium stearate - Hypromellose - Silica, colloidal anhydrous
Polnilo kapsule: - mikrokristalna celuloza - magnezijev stearat - hipromeloza - brezvoden koloidni silicijev dioksid
The recommended maximum daily dose is 6 mg twice a day.
• Najvišji dovoljeni odmerek je 6 mg dvakrat na dan.
You should not breast-feed during treatment with Rivastigmine HEXAL.
Med zdravljenjem z zdravilom Rivastigmin HEXAL ne smete dojiti.
The oral solution is packaged with an oral dosing syringe in a plastic tube container.
Peroralna raztopina je pakirana z brizgo za odmerjanje v plastičnem cevastem vsebniku.
Therefore, the ability of patients with dementia on rivastigmine to continue driving or operating complex machines should be routinely evaluated by the treating physician.
Zato mora lečeči zdravnik pri bolnikih z demenco, ki jemljejo rivastigmin, redno ocenjevati sposobnost za upravljanje motornih vozil ali zapletenih strojev.
Rivastigmine HEXAL may cause dizziness and somnolence, mainly at the start of treatment or when increasing the dose.
Rivastigmin HEXAL lahko povzroči vrtoglavost in zaspanost, predvsem na začetku zdravljenja ali ob povečanju odmerka.
One of the inactive ingredients in Rivastigmine HEXAL oral solution is sodium benzoate.
Ena od neaktivnih sestavin peroralne raztopine Rivastigmin HEXAL je natrijev benzoat.
Rivastigmine may cause increased gastric acid secretions.
Rivastigmin lahko povzroči povečano izločanje želodčne kisline.
Quinoline yellow WS dye (E104) Purified water
barvilo (E104) in prečiščena voda.
• Being violently sick (vomiting) that can cause tearing of the tube that connects your mouth with your stomach (oesophagus)
• močno bruhanje, ki lahko povzroči raztrganje požiralnika (cevi med usti in želodcem)
• Stomach problems such as feeling sick (nausea) or being sick (vomiting), diarrhoea
• prebavne težave, kot so navzea (slabost s siljenjem na bruhanje) ali bruhanje, driska
Rivastigmine oral solution and rivastigmine capsules may be interchanged at equal doses.
Enaki odmerki peroralne raztopine rivastigmina in kapsul rivastigmina so med seboj zamenljivi.
- Printing ink: - Shellac - Titanium dioxide (E171)
- šelak - titanov dioksid (E171)
What Rivastigmine HEXAL looks like and contents of the pack
Izgled zdravila Rivastigmin HEXAL in vsebina pakiranja
Benzoic acid is a mild irritant to the skin, eyes and mucous membranes.
Benzojeva kislina blago draži kožo, oči in sluznice.
• Push down and turn the child resistant cap to open bottle.
• Steklenico odprete tako, da zaporko, varno za otroke, potisnete navzdol in jo zavrtite.
Some cases of severe vomiting were associated with oesophageal rupture (see section 4.8).
V nekaterih primerih je bilo hudo bruhanje povezano z rupturo požiralnika (glejte poglavje 4.8).
Administration of rivastigmine oral solution with food delays absorption (tmax) by 74 min and lowers Cmax by 43% and increases AUC by approximately 9%.
Jemanje peroralne raztopine rivastigmina skupaj s hrano upočasni absorpcijo (tmax) za 74 minut, zmanjša Cmax za 43 % ter poveča
You may have side effects more often when you start your medicine or when your dose is increased.
Neželeni učinki so lahko pogostejši na začetku jemanja zdravila in ob povečanju odmerka.
- if you have, or have ever had, irregular or slow heartbeat.
- če imate ali če ste kdaj imeli nepravilen ali počasen srčni utrip, - če imate ali ste imeli aktivno želodčno razjedo,
Patients with severe hepatic impairment have not been studied, however, rivastigmine oral solution may be used in this patient population provided close monitoring is exercised (see sections 4.4 and
Uporabe zdravila pri bolnikih s težko jetrno okvaro niso proučili, vendar se peroralna raztopina rivastigmina lahko uporablja pri tej populaciji bolnikov, če se izvaja natančno spremljanje (glejte poglavji 4.4 in 5.2).
• Take the syringe out of its protective case.
• Brizgo vzemite iz varovalnega tulca.
CARTON FOR GLASS BOTTLE LABEL FOR GLASS BOTTLE
PODATKI NA ZUNANJI OVOJNINI ŠKATLA ZA STEKLENICO NALEPKA ZA STEKLENICO
Rivastigmine Hexal should not be given at the same time as metoclopramide (a medicine used to relieve or prevent nausea and vomiting).
Zdravilo Rivastigmin HEXAL se ne sme uporabljati skupaj z metoklopramidom (zdravilo za lašanje ali preprečevanje slabosti in bruhanja).
How to take Rivastigmine HEXAL
Kako jemati zdravilo Rivastigmin HEXAL
The prescribed amount of solution should be withdrawn from the container using the oral dosing syringe supplied.
Predpisano količino raztopine mora vzeti iz vsebnika s priloženo brizgo za peroralno odmerjanje.
- Capsule shell: - Gelatin - Titanium dioxide (E171) - Yellow iron oxide (E172)
Ovojnica kapsule: - želatina - titanov dioksid (E171) - rumeni železov oksid (E172)
Symptomatic treatment for other adverse reactions should be given as necessary.
Pri drugih neželenih učinkih se uporabljajo simptomatski zdravilni ukrepi, če je potrebno.
• Take Rivastigmine HEXAL twice a day in the morning and evening with food.
• Zdravilo Rivastigmin HEXAL jemljite s hrano dvakrat na dan, zjutraj in zvečer.
In patients with Alzheimer's disease, inhibition of AChE in CSF by rivastigmine was dose-dependent up to 6 mg given twice daily, the highest dose tested.
Pri bolnikih z Alzheimerjevo boleznijo je bila stopnja inhibicije AChE v CSF z rivastigminom odvisna od odmerka do največjega preizkušanega odmerka 6 mg, danega dvakrat na dan. Inhibicija aktivnosti butirilholinesteraze v CSF pri 14 bolnikih z Alzheimerjevo boleznijo, zdravljenih z rivastigminom, je bila podobna kot inhibicija AChE.
Rivastigmine HEXAL 3 mg and 6 mg hard capsules:
Rivastigmin HEXAL 3 mg in 6 mg trde kapsule:
Since bradycardia constitutes a risk factor in the occurrence of torsades de pointes, the combination of rivastigmine with torsades de pointes-inducing medicinal products such as antipsychotics i.e. some phenothiazines (chlorpromazine, levomepromazine), benzamides (sulpiride, sultopride, amisulpride, tiapride, veralipride), pimozide, haloperidol, droperidol, cisapride, citalopram, diphemanil, erythromycin IV, halofantrin, mizolastin, methadone, pentamidine and moxifloxacine should be observed with caution and clinical monitoring (ECG) may also be required.
nekateri fenotiazini (klorpromazin, levomepromazin), benzamidi (sulpirid, sultoprid, amisulprid, tiaprid, veraliprid), pimozid, haloperidol, droperidol, cisaprid, citalopram, difemanil, eritromicin iv., halofantrin, mizolastin, metadon, pentamidin in moksifloksacin.