natgillin/translations-raw huggingface dataset:
The following adverse reactions have been reported with either Twinrix or with GlaxoSmithKline monovalent hepatitis A or B vaccines:
Poročali so o naslednjih neželenih reakcijah po cepljenju s cepivom Twinrix ali z monovalentnima cepivoma proti hepatitisu A ali hepatitisu B izdelovalca GlaxoSmithKline: Infekcijske in parazitske bolezni meningitis
12 months after the first dose Your doctor will advise on the possible need for extra doses, and future booster dosing.
Vaš zdravnik vam bo svetoval v primeru, da bi potrebovali dodatne odmerke cepiva in kasnejše poživitvene odmerke.
• Swollen glands in the neck armpit or groin (lymphadenopathy)
• povečane bezgavke na vratu, pod pazduho ali v dimljah (limfadenopatija),
Swelling at the injection site, injection site reactions (such as haematoma, pruritus and bruising), malaise Uncommon Fever (≥ 37.5°C) Rare
srbenje in pojav modric), občutek slabosti občasni zvišana telesna temperatura (≥ 37,5 °C)
A. MANUFACTURER OF THE BIOLOGICAL ACTIVE SUBSTANCES AND MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
A. IZDELOVALEC BIOLOŠKE ZDRAVILNE UČINKOVINE
Very rare (These may occur in up to 1 in 10,000 doses of the vaccine):
Zelo redki (ki se lahko pojavijo pri največ 1 od 10.000 odmerkov cepiva):
• Vomiting, stomach pain
• bruhanje, bolečine v trebuhu, • boleče mišice,
10 pre-filled syringes + 10 needles 10 x 1 dose (1 ml)
10 napolnjenih injekcijskih brizg + 10 igel 10 x 1 odmerek (1 ml)
• Fits or seizures
• krči ali napadi krčev,
The effect of Twinrix Adult on embryo-fetal, peri-natal and post-natal survival and development has not been prospectively evaluated in clinical trials.
V kliničnih preskušanjih vpliva cepiva Twinrix za odrasle na embriofetalno, perinatalno in postnatalno preživetje ter razvoj prospektivno niso ovrednotili.
3Produced in yeast cells (Saccharomyces cerevisiae) by recombinant DNA technology 4Adsorbed on aluminium phosphate
3Pridobljen s tehnologijo rekombinantne DNA na celični kulturi kvasovk (Saccharomyces cerevisiae)
Adult achieved seroprotective levels of anti-HBV antibodies (≥ 10 mIU/ml) and Geometric Mean
En mesec po tem odmerku je 95 % oseb, cepljenih s cepivom Twinrix za odrasle, doseglo seroprotektivno koncentracijo protiteles anti-HBV (≥ 10 mi.e./ml), geometrijska srednja vrednost koncentracij (GMC - geometric mean concentrations) pa se je povečala za 179-krat
- The other ingredients in Twinrix Adult are: sodium chloride, water for injections.
0,4 miligrama Al3+ - Pomožne snovi cepiva Twinrix za odrasle so: natrijev klorid in voda za injekcije.
Gastrointestinal symptoms, diarrhoea, nausea
Bolezni prebavil pogosti gastrointestinalni simptomi, driska, navzea občasni bruhanje, bolečine v trebuhu*
Rare (These may occur in up to 1 in 1,000 doses of the vaccine):
Redki (ki se lahko pojavijo pri največ 1 od 1000 odmerkov cepiva):
Musculoskeletal and connective tissue disorders
Bolezni mišično-skeletnega sistema in vezivnega tkiva artritis, mišična oslabelost
• Swelling, bruising or itching at the injection site
• oteklina, pojav modric ali srbenja na mestu vboda,
These consist of nausea (feeling sick), fever and aches and pains.
Kažejo se v obliki siljenja na bruhanje, povišane telesne temperature in bolečin.
No data on concomitant administration of Twinrix Adult with specific hepatitis A immunoglobulin or hepatitis B immunoglobulin have been generated.
Ni zbranih podatkov o sočasnem dajanju cepiva Twinrix za odrasle in specifičnih imunoglobulinov proti hepatitisu A ali hepatitisu B. Vsekakor pa, kadar sta bili monovalentni cepivi proti hepatitisu A
- Booster dose
- Poživitveni odmerek
Following widespread use of the monovalent hepatitis A and/or hepatitis B vaccines, the following undesirable events have additionally been reported in temporal association with vaccination: Nervous system disorders
Pri spremljanju množične uporabe monovalentnih cepiv proti hepatitisu A in/ali hepatitisu B so dodatno poročali o naslednjih neželenih učinkih, ki so bili časovno povezani s cepljenjem: Bolezni živčevja multipla skleroza, mielitis, ohromelost obraza, polinevritis, kot je Guillain-Barréjev sindrom (z ascendentno paralizo), optični nevritis
• Feeling of pins and needles (paraesthesia)
• občutek mravljinčenja (parestezija),
It is not known whether Twinrix Adult will prevent hepatitis A and hepatitis B in such cases.
Obstaja možnost, da so osebe v času cepljenja v inkubacijski dobi za hepatitis A ali hepatitis B. Ni znano, če Twinrix za odrasle v teh primerih prepreči bolezni.
Since intradermal injection or intramuscular administration into the gluteal muscle could lead to a suboptimal response to the vaccine, these routes should be avoided.
Cepiva se ne daje intradermalno ali intramuskularno v glutealno mišico, ker je mogoče, da se na ta način ne doseže ustreznega imunskega odgovora.
• Third dose:
• tretji odmerek:
The most commonly reported adverse reactions following Twinrix Adult administration with the standard 0, 1, 6 month schedule are pain and redness occurring in a per dose frequency of 37.6% and 17.0% respectively.
mesecev sta bili najbolj pogosto poročani neželeni reakciji bolečina in rdečina s pogostnostjo 37,6 %
Twinrix Adult, Suspension for injection in pre-filled syringe Hepatitis A (inactivated) and hepatitis B (rDNA) (HAB) vaccine (adsorbed)
Twinrix za odrasle suspenzija za injiciranje v napolnjeni injekcijski brizgi cepivo proti hepatitisu A, inaktivirano, in hepatitisu B, rekombinantno (HAB), adsorbirano
Thrombocytopenia, thrombocytopenic purpura
Bolezni krvi in limfatičnega sistema trombocitopenija, trombocitopenična purpura
If not, you may not be fully protected against the diseases.
V kolikor jih niste, obstaja možnost, da niste v celoti zaščiteni proti hepatitisu A in hepatitisu B.
A fourth dose is recommended at 12 months.
Cepljenje s četrtim odmerkom je priporočljivo dvanajst mesecev po cepljenju s prvim odmerkom.
Uncommon Upper respiratory tract infection
Infekcijske in parazitske bolezni občasni okužba zgornjih dihalnih poti
HAB vaccine
Žilne bolezni vaskulitis
Very common Pain and redness at the injection site, fatigue
Splošne težave in spremembe na mestu aplikacije takojšnja bolečina na mestu vboda
Common (These may occur in up to 1 in 10 doses of the vaccine):
Pogosti (ki se lahko pojavijo pri največ 1 od 10 odmerkov cepiva):
Uncommon Myalgia Rare
Žilne bolezni redki hipotenzija
10 x 1 dose (1 ml)
10 napolnjenih injekcijskih brizg 10 x 1 odmerek (1 ml)
25 x 1 dose (1 ml)
25 napolnjenih injekcijskih brizg 25 x 1 odmerek (1 ml)
Consideration should be given to serological testing of those subjects who may be at risk of not achieving seroprotection following a complete course of Twinrix Adult.
Pri bolnikih, pri katerih obstaja tveganje, da po osnovni shemi cepljenja s cepivom Twinrix za odrasle ne bodo razvili ustrezne serozaščite, je potrebno razmišljati o serološkem testiranju.
Vascular disorders
intramuskularna uporaba
Suspension for injection in pre-filled syringe.
kot psihološki odziv na injiciranje z iglo.
• Immediate injection site pain, stinging and burning feeling
• bolezen očesnih živcev (optični nevritis), • takojšnja bolečina na mestu vboda, občutek zbadanja in pekoč občutek.
NAME OF THE MEDICINAL PRODUCT Twinrix Adult, suspension for injection Hepatitis A (inactivated) and hepatitis B (rDNA) (HAB) vaccine (adsorbed).
Twinrix za odrasle suspenzija za injiciranje cepivo proti hepatitisu A, inaktivirano, in hepatitisu B, rekombinantno (HAB), adsorbirano
Decreased appetite
Presnovne in prehranske motnje redki zmanjšan apetit
• Tiredness
• srbečica,
The recommended schedule should be adhered to. Once initiated, the primary course of vaccination should be completed with the same vaccine.
Za vse odmerke osnovnega cepljenja je potrebno uporabiti isto cepivo.
Additional doses may need to be considered for persons who do not respond or have a suboptimal response to a course of vaccinations.
Bolniki z zmanjšanim odzivom na cepljenje ali brez bodo morda potrebovali dodatne odmerke.
Obesity (defined as BMI ≥ 30 kg/m2) has been observed to reduce the immune response to hepatitis A vaccines.
Ugotovljeno je bilo, da prekomerna telesna masa (definirana z indeksom telesne mase (ITM) ≥ 30 kg/m2) zmanjša imunski odziv na cepiva proti hepatitisu A. Ugotovljeni so bili še številni drugi dejavniki, ki vplivajo na slabši imunski odziv po cepljenju s cepivi proti hepatitisu B. To so: višja starost, moški spol, debelost, kajenje, način dajanja cepiva ali nekatere obstoječe kronične bolezni.
Sodium chloride
Adsorbiran na aluminijev fosfat
What Twinrix Adult looks like and contents of the pack
Shranjevanje cepiva Twinrix za odrasle Vsebina pakiranja in dodatne informacije
MANUFACTURER OF THE BIOLOGICAL ACTIVE SUBSTANCES AND MANUFACTURER RESPONSIBLE FOR BATCH RELEASE
IZDELOVALEC, ODGOVOREN ZA SPROŠČANJE SERIJ
However, this route of administration may result in suboptimal immune response to the vaccine (see section 4.4).
Vsekakor pa se lahko zaradi tega pričakuje pomanjkljiv imunski odgovor na cepljenje
• Dizziness
• utrujenost.
Talk to your doctor or pharmacist before receiving Twinrix Adult if
Opozorila in previdnostni ukrepi Pred začetkom cepljenja s cepivom Twinrix za odrasle se posvetujte z zdravnikom ali farmacevtom,
GlaxoSmithKline S.p.A. Tel: + 39 (0)45 9218 111
Tel: + 39(0)45 9218 111
Very common (These may occur in 1 in 10 doses or more of the vaccine):
Zelo pogosti (ki se lahko pojavijo pri več kot 1 od 10 odmerkov cepiva): • glavobol,
• Joint swelling, muscular weakness
(multiformni eritem), koprivnica, • oteklost sklepov, mišična oslabelost,
Turbid white suspension.
- Navodilo shranite.
In a clinical study conducted in subjects over 40 years of age, the seropositivity rate for anti-HAV antibodies and seroprotection rate against hepatitis B of Twinrix Adult following a 0, 1, 6 months schedule were compared with the seropositivity and seroprotection rates of monovalent hepatitis A and B vaccines when administered in opposite arms.
1-6) v primerjavi s seropozitivnostjo in stopnjo serumske zaščite po monovalentnih cepivih hepatitisa
Very common Headache Uncommon Dizziness Rare
Bolezni kože in podkožja redki izpuščaj, srbenje zelo redki koprivnica
Hypersensitivity after previous administration of hepatitis A and/or hepatitis B vaccines.
Preobčutljivost po predhodnem cepljenju s cepivi proti hepatitisu A in/ali hepatitisu B. Cepljenje s cepivom Twinrix za odrasle je treba odložiti pri osebah, ki imajo težjo akutno vročinsko bolezen.
This can be fatal in some people.
Pri nekaterih ljudeh je to lahko smrtno.
You need to be aware of the extra risks:
Bodite pozorni na dodatna tveganja:
Let it dry completely before you use it again.
Pustite ga, da se popolnoma posuši, preden ga ponovno uporabite.
Experience in children and adolescents
Izkušnje pri otrocih in mladostnikih
No fatalities occurred, and the patients recovered.
Smrtnih izidov ni bilo, bolniki pa so okrevali.
8 Repeat steps 3 to 7 in the same way until you have taken your whole dose.
8 Na enak način ponavljajte korake od 3 do 7, dokler ne vzamete svojega celotnega odmerka.
• if you're seriously overweight (especially if you're a woman).
• če imate znatno prekomerno telesno maso (še posebej, če ste ženska).
Stay in regular contact with your doctor
Bodite v rednih stikih z vašim zdravnikom
Maintenance dose once daily
Vzdrževalni odmerek enkrat dnevno
• Risk Management Plan (RMP)
 Načrt obvladovanja tveganja (RMP)
- All patients
- Vsi bolniki
This dose needs to be further substantiated.
Ta odmerek je treba še dodatno potrditi.
However, formal interaction studies have not been performed.
Vendar formalne študije o interakcijah še niso bile izvedene.
If you forget to take a dose, take it as soon as you remember.
Če ste odmerek pozabili vzeti, ga vzemite takoj, ko se spomnite.
2 Hold the bottle.
2 Držite stekleničko.
The neurological disorders might be transient or permanent.
Nevrološke motnje so lahko prehodne ali trajne.
After first opening: 1 month
Po prvem odprtju: 1 mesec
Subjects, % (no.)
Osebe, % (št.)
Based on limited data in children aged 2 to 17 years, there were no new safety issues identified compared to adults.
Na podlagi omejenih podatkov za otroke starosti med 2 in 17 let, ni bilo ugotovljenih novih varnostnih vprašanj v primerjavi z odraslimi.
Then continue your treatment as before.
Nato nadaljujte z zdravljenjem tako, kot pred tem.
How to measure the dose and take the medicine
Kako meriti odmerek in jemati zdravilo
There is a risk of your hepatitis getting worse (see section 2).
Obstaja tveganje, da se vam hepatitis poslabša (glejte poglavje 2).
For example, if your dose is 20 ml, you need to take 2 applicator-fulls of medicine.
Če je na primer vaš odmerek 20 ml, morate vzeti 2 polna aplikatorja zdravila.
If you are pregnant, think you may be pregnant or are planning to have a baby:
Če ste noseči, menite, da bi lahko bili noseči ali načrtujete nosečnost:
9 Take the applicator out of the bottle and wash it thoroughly in clean water.
9 Vzemite aplikator iz stekleničke in ga skrbno operite s čisto vodo.
Undetectable HBV DNA
Nezaznavna HBV DNA
The safety and efficacy of Zeffix in infants, children and adolescents aged below 18 years have not been established.
Varnost in učinkovitost zdravila Zeffix pri otrocih in mladostnikih starih manj kot 18 let ni bila dokazana.
5 Pull out the applicator plunger (D) until the applicator contains the first part of your full dose.
5 Izvlecite bat aplikatorja (D), dokler aplikator ne vsebuje prvega dela vašega polnega odmerka.
Push the adapter (B) firmly into the neck of the bottle, as far as it will go.
Potisnite nastavek (B) trdno v vrat stekleničke, kolikor daleč gre.
Swallow the tablet whole, with some water.
Tableto pogoltnite celo z malo vode.
Keep it safely.
Varno jo shranite.
Comparative data according to YMDD status were also available for histological assessment but only up to three years.
Na voljo so tudi primerjalni podatki o histološki oceni glede na YMDD status, vendar le za obdobje do treh let.
Don't take a double dose to make up for a missed dose.
Ne vzemite dvojnega odmerka, da bi nadoknadili izpuščeni odmerek.
Zeffix can be used during pregnancy if clinically needed.
Zdravilo Zeffix se lahko uporablja med nosečnostjo, če je klinično potrebno.
Date of latest renewal: 23 June 2014
Datum prve odobritve: 29. julij 1999 Datum zadnjega podaljšanja: 23. junij 2014
Most events have been self-limiting, however some fatalities have been observed.
Večina dogodkov je minila sama, bilo pa je tudi nekaj smrtnih primerov.
See Section 4 for more information about the risks.
Za več informacij glede tveganj glejte poglavje 4.
• if you have ever had other types of liver disease, such as hepatitis C
• če ste kdaj imeli druge vrste bolezni jeter, kot npr. hepatitis C;
Not all pack-sizes may be available in your country.
V vaši državi morda ni na voljo vseh navedenih pakiranj.
This should lead to a reduction in liver damage and an improvement in your liver function.
To naj bi vodilo do zmanjšanja okvare jeter in izboljšanja v njihovem delovanju.
Do not throw away any medicines in your wastewater or household rubbish.
Zdravila ne smete odvreči v odpadne vode ali med gospodinjske odpadke.
During treatment with Zeffix patients should be monitored regularly.
Med zdravljenjem z zdravilom Zeffix je treba bolnike redno nadzirati.
If you are planning to change your HIV treatment, discuss this change with your doctor first.
Če nameravate spremeniti svoje zdravljenje HIV, se o spremembi najprej posvetujte z zdravnikom.
These events were seen infrequently in clinical studies.
Ti dogodki v kliničnih študijah niso bili pogosti.
Don't push too hard and squirt the liquid into the back of your throat, or you may choke.
Ne potisnite premočno in ne brizgnite tekočine v zadnji del žrela, ker se lahko zadušite.
Synthetic yellow and red iron oxides
sintetični rumeni in rdeči železov oksid
Abnormal Value
Nenormalna vrednost
Talk to your doctor about the risks and benefits of taking Zeffix during your pregnancy.
Posvetujte se z zdravnikom glede tveganj in koristi jemanja zdravila Zeffix med vašo nosečnostjo.
Remove the applicator from the adapter.
Odstranite aplikator z nastavka.
Most events have been self-limited, however fatalities have been observed very rarely (see section 4.4).
Večina primerov je bilo izoliranih, kljub temu pa so se smrtni primeri pojavili zelo redko (glejte poglavje 4.4).
Delta hepatitis or hepatitis C
Hepatitis delta ali hepatitis C
Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine.
Druga zdravila (npr. ranitidin, cimetidin) se le deloma izločajo s pomočjo tega mehanizma in niso kazala interakcij z lamivudinom.
No patients in either group progressed to cirrhosis.
Pri nobenem od bolnikov v obeh skupinah ni prišlo do progresije v cirozo.
Don't drive or use machines unless you are sure you're not affected.
Ne upravljajte z vozili ali stroji, če se ne počutite dobro.
It has a very low potential to decrease mitochondrial DNA content, is not permanently incorporated into mitochondrial DNA, and does not act as an inhibitor of mitochondrial DNA polymerase gamma.
Ima zelo majhen potencial za zmanjševanje vsebnosti mitohondrijske DNA, v mitohondrijsko DNA se ne vključi permanentno in ne deluje kot zaviralec mitohondrijske DNA polimeraze gama.
• other medicines containing lamivudine, used to treat HIV infection (sometimes called the AIDS virus)
• ostala zdravila, ki vsebujejo lamivudin, ki se uporablja pri zdravljenju okužbe s HIV (včasih se uporablja izraz virus AIDS-a),
Currently available data are described in sections 4.4 and 5.1 but no recommendation on a posology can be made.
Na podlagi zadnjih dostopnih podatkov, ki so opisani v poglavjih 4.4 in 5.1 ni mogoče dati priporočil glede odmerjanja.
Lamivudine is well absorbed from the gastrointestinal tract, and the bioavailability of oral lamivudine in adults is normally between 80 and 85 %.
Lamivudin se iz gastrointestinalnega trakta dobro absorbira, biološka uporabnost peroralno danega lamivudina pri odraslih pa je normalno med 80 in 85 %.
Duration of treatment The optimal duration of treatment is unknown.
Optimalni čas zdravljenja ni znan.
The results of long term carcinogenicity studies with lamivudine in rats and mice did not shown any carcinogenic potential.
Rezultati dolgotrajnih študij o kancerogenosti lamivudina pri podganah in miših niso pokazali nobenega kancerogenega potenciala.
Following oral administration, the mean time (tmax) to maximal serum concentrations (Cmax) is about an hour.
Po peroralnem vnosu je povprečen čas (tmax) do dosežene maksimalne serumske koncentracije (Cmax) približno ena ura.
Interaction studies have only been performed in adults.
Študije medsebojnega delovanja z drugimi zdravili so bile izvedene le pri odraslih.
No specific signs or symptoms have been identified following such overdose.
Po takšnem prevelikem odmerjanju specifični znaki ali simptomi niso bili opaženi.
YMDD mutant HBV status
Status YMDD mutanta HBV
Slowly push the plunger in, allowing time to swallow.
Bat počasi potiskajte noter, da boste imeli čas pogoltniti.
Creatinine clearance ml/min
Očistek kreatinina ml/min
With prolonged treatment, regular reassessment is recommended to confirm that continuation of the selected therapy remains appropriate for the patient.
Med dolgotrajnim zdravljenjem so priporočljive redne ponovne ocene za potrditev, da je nadaljevanje izbranega zdravljenja za bolnika ustrezno.
• lactic acidosis (excess lactic acid in the blood).
• laktacidoza (presežek mlečne kisline v krvi).
From intravenous studies the mean volume of distribution is 1.3 l/kg.
Z intravenskimi študijami je bil ugotovljen povprečni volumen porazdelitve 1,3 l/kg.
However, relapse following seroconversion can occur.
Vendar pa lahko po serokonverziji pride do relapsa.
Due to similarities, Zeffix should not be administered concomitantly with other cytidine analogues, such as emtricitabine.
Zaradi podobnosti, se Zeffix ne sme dajati sočasno z ostalimi analogi citidina, npr. emtricitabinom.
Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Podrobne informacije o tem zdravilu so na voljo na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu
Transmission of hepatitis B
Prenos hepatitisa B
Less than 1% of these women have been treated for HBV, whereas the majority was treated for HIV at higher doses and with other concomitant medications.
Manj kot 1 % teh žensk se je zdravilo zaradi HBV; večina se je zdravila zaradi okužbe z virusom HIV, z večjimi odmerki in sočasno z drugimi zdravili.
Zeffix may make you feel tired, which could affect your ability to drive or use machines.
Zdravilo Zeffix lahko povzroči utrujenost, kar lahko vpliva na vašo sposobnost upravljanja vozil in strojev.
Improvement in liver function was also seen after one year of therapy.
Po enem letu zdravljenja so opazili tudi izboljšanje jetrne funkcije.
Reduction of erythrocytes and neutrophil counts were identified as the effects most likely to be of clinical relevance.
Zmanjšanje števila eritrocitov in nevtrofilcev se je pokazal kot učinek z najverjetnejšo klinično pomembnostjo.
Discard one month after first opening.
Zavrzite en mesec po prvem odprtju.
7 Put the applicator into your mouth, placing the tip of the applicator against the inside of your cheek.
7 Položite aplikator v usta tako, da je konica aplikatorja ob notranji strani lica.
Tell your doctor or pharmacist if you're taking, have recently taken or might take any other medicines, including herbal medicines or other medicines you bought without a prescription.
Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katerokoli drugo zdravilo, vključno z zdravili rastlinskega izvora ali drugimi zdravili, ki ste jih kupili brez recepta.
The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when their main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim.
Treba je upoštevati možnost interakcij z drugimi zdravili, ki se uporabljajo sočasno, še posebno, če je njihova glavna pot izločanja aktivna renalna sekrecija preko organskega kationskega transportnega sistema, npr. trimetoprim.
The frequency categories assigned to the adverse reactions are mainly based on experience from clinical trials including a total of 1,171 patients with chronic hepatitis B receiving lamivudine at 100mg.
Kategorije pogostnosti, pripisane neželenim učinkom, v glavnem temeljijo na izkušnjah iz kliničnih preskušanj s skupaj 1171 bolniki s kroničnim hepatitisom B, ki so prejemali 100 mg lamivudina.
Zeffix also contains preservatives (parahydroxybenzoates) which may cause allergic reactions (possibly delayed).
Zdravilo Zeffix vsebuje tudi konzervanse (parahidroksibenzoate), ki lahko povzročijo alergijske reakcije (lahko tudi zapoznele).
4 Turn the bottle upside down.
4 Obrnite stekleničko navzdol.
3 Insert the applicator (C) firmly into the adapter.
3 aplikator (C) trdno vstavite v nastavek.
HIV co-infection
Sočasna okužba z virusom HIV
A modest increase in Cmax (28 %) was observed for zidovudine when administered with lamivudine, however overall exposure (AUC) was not significantly altered.
Opaženo je bilo zmerno zvečanje Cmax (28 %) zidovudina, če se je uporabljal sočasno z lamivudinom, vendar se celotna izpostavljenost (AUC) ni znatno spremenila.
Leave the adapter in the bottle.
Nastavek pustite v steklenički.
Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Bolniki z redkimi heriditarnimi težavami intolerance za fruktozo, malabsorpcije tipa glukozagalaktoza ali insuficience saharaze-izomaltaze, tega zdravila ne smejo jemati.
Lamivudine has been administered to children and adolescents with compensated CHB in a placebo controlled study of 286 patients aged 2 to 17 years.
Lamivudin so dajali otrokom in mladostnikom s kompenziranim CHB med s placebom nadzorovano študijo pri 286 bolnikih, starih od 2 do 17 let.