natgillin/translations-raw huggingface dataset:
The primary analysis of this study was performed on the population of all patients randomly assigned to a treatment arm who received study drug (randomised and treated).
Primarno analizo te študije so opravili na populaciji vseh bolnikov, ki so bili naključno dodeljeni v vejo zdravljenja, kjer so prejemali zdravilo v preskušanju (randomizirani in zdravljeni).
Pancytopenia- combined low counts of white cells, red cells and platelets Radiation pneumonitis (scarring of the air sacs of the lung associated with radiation therapy) may occur in patients who are also treated with radiation either before, during or after their pemetrexed therapy.
Pancitopenija - skupno nizko število belih krvnih celic, rdečih krvnih celic in trombocitov Radiacijska pljučnica (brazgotinjenje pljučnih mešičkov, povezano z obsevanjem) se lahko pojavi pri bolnikih, ki so zdravljeni tudi z obsevanjem pred, med ali po zdravljenju s pemetreksedom.
Leucocytes decreased 17.8 Platelets decreased
Znižani levkociti 17,8 Znižani trombociti
Creatinine elevation Creatinine clearance decreased**
Povišan kreatinin 10,7 Znižan očistek kreatinina**
Each pack contains one glass vial of 100 mg, 500 mg or 1,000 mg pemetrexed.
Vsako pakiranje vsebuje eno stekleno vialo s 100 mg, 500 mg ali 1.000 mg pemetrekseda.
Large cell (N = 153)
Velike celice (N = 153)
Dose adjustments at the start of a subsequent cycle should be based on nadir haematologic counts or maximum non-haematologic toxicity from the preceding cycle of therapy.
Prilagajanja odmerkov na začetku naslednjega ciklusa naj temeljijo na najnižjih hematoloških vrednostih ali na največji nehematološki toksičnosti iz predhodnega ciklusa zdravljenja.
Pemetrexed must only be administered under the supervision of a physician qualified in the use of anti-cancer chemotherapy.
Pemetreksed smemo dajati le pod nadzorom zdravnika, usposobljenega za uporabo kemoterapije za zdravljenje raka.
Men are advised not to father a child during and up to 6 months following treatment with pemetrexed and should therefore use effective contraception during treatment with pemetrexed and for up to 6 months afterwards.
Moškim odsvetujemo, da bi v času zdravljenja s pemetreksedom ter do 6 mesecev po zdravljenju s tem zdravilom spočeli otroka, zato naj v času zdravljenja s pemetreksedom ter do 6 mesecev po zdravljenju s tem zdravilom uporabljajo učinkovito kontracepcijo.
Store below 30°C
Shranjujte pri temperaturi do 30 °C.
Thus, drainage of third-space fluid collection prior to pemetrexed treatment should be considered, but may not be necessary.
Zato je pred zdravljenjem s pemetreskedom vredno premisliti o drenaži tekočine tretjega prostora, čeprav to morda ni potrebno.
* Refer to National Cancer Institute CTC version 2 for each grade of toxicity except the term “creatinine clearance decreased”.
* Glejte CTC Nacionalnega inštituta za rakava obolenja, različico 2, za vsako stopnjo toksičnosti, razen izraza “znižan očistek kreatinina”.
Your doctor may decide to change the dose or delay treating you depending on your general condition and if your blood cell counts are too low.
Zdravnik se bo morda odločil spremeniti odmerek ali odložiti zdravljenje, odvisno od vašega splošnega stanja, ter ob prenizkem številu krvnih celic.
A hospital pharmacist, nurse or doctor will have mixed the Pemetrexed Pfizer powder with water for injections and 5% glucose solution for injection before it is given to you.
Bolnišnični farmacevt, medicinska sestra ali zdravnik bo prašek Pemetreksed Pfizer, preden ga boste prejeli, zmešal z vodo za injekcije in 5-odstotno raztopino glukoze za injiciranje.
Patients received a median of 5 cycles of maintenance treatment with pemetrexed and 3.5 cycles of placebo.
Bolniki so dobili povprečno 5 ciklov vzdrževalnega zdravljenja s pemetreksedom in 3,5 cikle placeba.
All patients received study therapy as initial treatment for locally advanced or metastatic NSCLC and patients in both treatment groups were fully supplemented with folic acid and vitamin B12.
Vsi bolniki so prejemali študijsko terapijo kot začetno zdravljenje za lokalno napredovali ali metastatski nedrobnocelični karcinom pljuč in bolniki v obeh skupinah zdravljenja so prejemali popolno dopolnilo s folno kislino in vitaminom B12.
• 95% CI for median
• 95 % IZ za mediano
Treatment with pemetrexed should be discontinued if a patient experiences any haematologic or nonhaematologic Grade 3 or 4 toxicity after 2 dose reductions or immediately if Grade 3 or 4 neurotoxicity is observed.
Zdravljenje spemetreksedom moramo prekiniti, če bolnik izkusi kakršnokoli hematološko ali nehematološko toksičnost stopnje 3 ali 4 po 2 znižanjih odmerka ali nemudoma, če opazimo nevrološko toksičnost stopnje 3 ali 4.
It must be administered as an intravenous infusion over 10 minutes on the first day of each 21-day cycle.
Dajati ga je treba kot 10-minutno intravensko infuzijo prvi dan vsakega 21-dnevnega ciklusa.
Patients should be regularly monitored for acute tubular necrosis, decreased renal function and signs and symptoms of nephrogenic diabetes insipidus (e.g. hypernatraemia).
Redno je treba spremljati, ali so se pri bolnikih pojavili akutna tubulna nekroza, zmanjšano delovanje ledvic ter znaki in simptomi nefrogenega diabetesa insipidusa (npr. hipernatriemija).
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Če imate kakršna koli dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom ali s farmacevtom.
Pemetrexed is transported into cells by both the reduced folate carrier and membrane folate binding protein transport systems.
Pemetreksed pride v celice s prenašalcem reduciranega folata in tudi preko membranskih transportnih sistemov folat vezavne beljakovine.
Preparation and administration precautions: As with other potentially toxic anti-cancer agents, care should be exercised in the handling and preparation of pemetrexed infusion solutions.
Previdnostni ukrepi pri pripravi in dajanju: Kot pri drugih potencialno toksičnih učinkovinah za zdravljenje raka je potrebna previdnost pri ravnanju z raztopinami pemetrekseda za infundiranje ter pripravi teh raztopin.
CTC a Grade
Stopnja CTC
Prior chemotherapy did not include pemetrexed.
Predhodna kemoterapija ni vključevala pemetrekseda.
As a result, concomitant use of live attenuated vaccines is not recommended (see sections 4.3 and 4.5).
Zato odsvetujemo uporabo živih oslabljenih cepiv (glejte poglavji 4.3 in 4.5).
Pemetrexed Pfizer is for intravenous use.
Zdravilo Pemetreksed Pfizer je za intravensko uporabo.
The separation between the treatment arms was achieved by improvement in lung function in the pemetrexed /cisplatin arm and deterioration of lung function over time in the control arm.
Razlikovanje med vejama zdravljenja je bilo doseženo z izboljšanjem delovanja pljuč v veji zdravljenja s pemetreksed/cisplatinom in poslabšanjem pljučnega delovanja s časom v kontrolni veji preskušanja.
Hypernatraemia - increased sodium in blood Inflammation of the skin, mainly of the lower limb with swelling, pain and redness
Hipernatriemija - zvišana raven natrija v krvi Vnetje kože, večinoma spodnjih okončin, z otekanjem, bolečino in pordelostjo
If particulate matter is observed, do not administer.
Če opazite trdne delce, te viale ne uporabite.
In a study conducted in beagle dog by intravenous bolus injection for 9 months, testicular findings (degeneration/necrosis of the seminiferous epithelium) have been observed.
V 9-mesečni študiji, ki so jo izvedli na psih pasme beagle tako, da so jim dajali intravenske injekcije v bolusu, so opazovali spremembe na testisih (degeneracija/nekroza seminifernega epitelija).
Kidney: abnormal blood tests
Ledvice: nenormalne vrednosti krvnih testov
An insufficient number of patients have been studied with creatinine clearance of below 45 ml/min.
Zadostnega števila bolnikov z očistkom kreatinina pod 45 ml/min niso preučili.
If you currently have or have previously had problems with your kidneys, talk to your doctor or hospital pharmacist as you may not be able to receive Pemetrexed Pfizer.
Če imate ali ste imeli težave z ledvicami, se pogovorite z zdravnikom ali bolnišničnim farmacevtom, ker morda ne boste mogli prejeti zdravila Pemetreksed Pfizer.
In vitro studies have shown that pemetrexed behaves as a multi-targeted antifolate by inhibiting thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), which are key folate-dependent enzymes for the de novo biosynthesis of thymidine and purine nucleotides.
Študije in vitro so pokazale, da se pemetreksed vede kot večtarčni antifolat z zaviranjem timidilatne sintaze (TS), dihidrofolatne reduktaze (DHFR) in glicinamidne ribonukleotidne formiltransferaze (GARFT), ki so ključni od folata odvisni encimi za de novo biosintezo timidinskih in purinskih nukleotidov.
75% of previous dose (both pemetrexed and cisplatin)
75 % predhodnega odmerka (obehpemetrekseda in cisplatina)
Therefore, the use of pemetrexed in patients with creatinine clearance of <45 ml/min is not recommended (see section 4.2).
Zato uporabe pemetrekseda pri bolnikih z očistkom kreatinina < 45 ml/min ne priporočamo (glejte poglavje 4.2).
Infectious and non-infectious disorders of the dermis, the hypodermis and/or the subcutaneous tissue have been reported with an unknown frequency (e.g. acute bacterial dermo-hypodermitis, pseudocellulitis, dermatitis).
Poročali so o nalezljivih in nenalezljivih boleznih dermisa, hipodermisa in/ali podkožja z neznano pogostnostjo (npr. akutni bakterijski dermohipodermitis, psevdocelulitis, dermatitis).
If patients develop non-haematologic toxicities ≥ Grade 3 (excluding neurotoxicity), pemetrexed should be withheld until resolution to less than or equal to the patient's pre-therapy value.
Če se pri bolnikih razvijejo nehematološke toksičnosti ≥ stopnje 3 (z izjemo nevrološke toksičnosti), moramo dajanje pemetrekseda prekiniti, dokler se vrednosti ne povrnejo na manjše ali enake, kot jih je imel bolnik pred zdravljenjem.
Contact your doctor if you get a severe rash, or itching, or blistering (Stevens-Johnson syndrome or toxic epidermal necrolysis).
Obvestite svojega zdravnika, če se pojavijo hud izpuščaj, srbenje ali mehurčki (Stevens-Johnsonov sindrom ali toksična epidermalna nekroliza).
Corticosteriods: your doctor will prescribe you steroid tablets (equivalent to 4 milligram of dexamethasone twice a day) that you will need to take on the day before, on the day of, and the day after Pemetrexed Pfizer treatment.
Kortikosteroidi: vaš zdravnik vam bo predpisal tablete steroidov (ustrezno 4 miligramom deksametazona dvakrat dnevno), ki jih boste morali jemati dan pred zdravljenjem z zdravilom Pemetreksed Pfizer, na dan zdravljenja in na dan po zdravljenju z zdravilom Pemetreksed Pfizer.
The incidence of adverse reactions was evaluated for patients who received ≤6 cycles of pemetrexed maintenance (N=519), and compared to patients who received >6 cycles of pemetrexed (N=281).
Pojavnost neželenih učinkov so ocenili za bolnike, ki so prejeli ≤ 6 ciklov vzdrževalnega zdravljenja s pemetreksedom (N=519) in jo primerjali z bolniki, ki so prejeli > 6 ciklov pemetrekseda (N=281).
Pre-treatment with dexamethasone (or equivalent) can reduce the incidence and severity of skin reactions (see section
Predhodno zdravljenje z deksametazonom (ali drugim ustreznim kortikosteroidom) lahko zmanjša incidenco in resnost kožnih reakcij (glejte poglavje 4.2).
AST (SGOT) elevation
SGOT (AST)
A subgroup analysis was performed on patients who received folic acid and vitamin B12 supplementation during the entire course of study therapy (fully supplemented).
Analizo podskupin so opravili pri bolnikih, ki so prejemali dopolnilna folno kislino in vitamin B12 celoten čas trajanja zdravljenja v študiji (popolno dopolnjevanje).
Administration of pemetrexed to male mice resulted in reproductive toxicity characterised by reduced fertility rates and testicular atrophy.
Dajanje pemetrekseda mišjim samcem je povzročilo reproduktivno toksičnost z nižjimi stopnjami plodnosti ter atrofijo testisov.
Cisplatin is also given by infusion into one of your veins, and is given approximately 30 minutes after the infusion of Pemetrexed Pfizer has finished.
Cisplatin ravno tako dajemo v obliki infuzije v veno, približno 30 minut po zaključku infuzije zdravila Pemetreksed Pfizer.
If you have been recently vaccinated, please tell your doctor, as this can possibly cause bad effects with Pemetrexed Pfizer.
Če ste bili nedavno cepljeni, prosimo, da o tem obvestite zdravnika, saj lahko to ob uporabi zdravila Pemetreksed Pfizer povzroča škodljive učinke.
Owing to the possibility of pemetrexed treatment causing irreversible infertility (see section 5.3), men are advised to seek counselling on sperm storage before starting treatment.
Zaradi možnosti, da zdravljenje s pemetreksedom povzroči trajno neplodnost (glejte poglavje 5.3), naj se moški pred začetkom zdravljenja posvetujejo o shranjevanju sperme.
Blood clots in the lung blood vessels (pulmonary embolism)
Krvni strdki v krvnih žilah v pljučih (pljučna embolija)
Rare cases of anaphylactic shock have been reported.
Poročali so o redkih primerih anafilaktičnega šoka.
There is not a specific antidote for extravasation of pemetrexed.
Za ekstravazacijo pemetrekseda ni specifičnega antidota.
Hyperpigmentation has been commonly reported.
Pogosto so poročali o hiperpigmentaciji.
To reduce toxicity, patients treated with pemetrexed must also receive vitamin supplementation (see section 4.4).
Za zmanjšanje toksičnosti moramo bolnikom, ki jih zdravimo s pemetreksedom, dati tudi dopolnila vitaminov (glejte poglavje 4.4).
Therefore, caution should be made when administering higher doses of NSAIDs or acetylsalicylic acid, concurrently with pemetrexed to patients with normal function (creatinine clearance ≥ 80 ml/min).
Zato je pri dajanju visokih odmerkov NSAID-ov ali acetilsalicilne kisline sočasno s pemetreksedom bolnikom z normalnim delovanjem ledvic (očistek kreatinina ≥ 80 ml/min) potrebna previdnost.
Cases of radiation recall have been reported in patients who received radiotherapy weeks or years previously.
Poročali so o radiacijskem izpuščaju pri bolnikih, ki so se zdravili z radioterapijo pred tedni ali leti.
Polyglutamated metabolites have an increased intracellular half-life resulting in prolonged drug action in malignant cells.
Poliglutamirani presnovki imajo podaljšani znotrajcelični razpolovni čas, kar povzroči podaljšano delovanje zdravila v malignih celicah.
There are insufficient data on the use of pemetrexed in patients with creatinine clearance below 45 ml/min; therefore, the use of pemetrexed is not recommended (see section 4.4).
O uporabi pemetrekseda pri bolnikih z očistkom kreatinina, nižjim od 45 ml/min, ni zadostnih podatkov; zato uporabe pemetrekseda ne priporočamo (glejte poglavje 4.4).
These differences were likely due to differences in the patient population, since the Phase 2 studies included both chemonaive and heavily pre-treated breast cancer patients with pre-existing liver metastases and/or abnormal baseline liver function tests.
Te razlike so bile verjetno posledica različnih populacij bolnikov, saj so v študijah faze 2 sodelovali bolniki, ki še niso prejemali kemoterapije, in tudi bolnice s karcinomom dojke, ki so v preteklosti prejemale kemoterapijo, s predhodno obstoječimi metastazami v jetrih in/ali nenormalnimi izhodiščnimi vrednostmi testov jetrnega delovanja.
Fast heart rate
Hiter srčni utrip
Pemetrexed Pfizer is a medicine used in the treatment of cancer.
Pemetreksed Pfizer je zdravilo, ki ga uporabljamo pri zdravljenju raka.
Superio rity pvalue pemetrexed + cisplatin gemcitabine + cisplatin
Prednost pvrednost pemetreksed + cisplatin gemcitabin + cisplatin
ITT population (N = 1725)
NZ populacija (N = 1725)
Interactions common to all cytotoxics
Medsebojna delovanja, ki so skupna vsem citotoksičnim zdravilom
Patients received a median of 4 cycles of maintenance treatment with pemetrexed and 4 cycles of placebo.
Bolniki so prejeli mediano 4 cikle vzdrževalnega zdravljenja s pemetreksedom in 4 cikle placeba.
***Integrated adverse reactions table combines the results of the JMEN pemetrexed maintenance (N=663) and PARAMOUNT continuation pemetrexed maintenance (N=539) studies.
***Skupna preglednica neželenih učinkov združuje rezultate študij vzdrževalnega zdravljenja samo s pemetreksedom JMEN (N=663) in nadaljevalnega zdravljenja s pemetreksedom (PARAMOUNT: N=539).
Do not use this medicine after the expiry date which is stated on the carton and label after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in nalepki poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
Loss of sensation
Izguba občutka
Concomitant administration of substances that are also tubularly secreted (e.g., probenecid, penicillin) could potentially result in delayed clearance of pemetrexed.
Sočasno dajanje snovi, ki se tudi izločajo s tubulno sekrecijo (denimo, probenecid, penicilin), lahko potencialno povzroči zakasnjeni očistek pemetrekseda.
Of the 939 patients treated with pemetrexed plus cisplatin induction, 539 patients were randomised to maintenance treatment with pemetrexed or placebo.
Izmed 939 bolnikov, ki so bili zdravljeni s pemetreksedom in indukcijskim zdravilom cisplatina, je bilo naključno izbranih za vzdrževalno zdravljenje s pemetreksedom ali s placebom.
Other undesirable effects include renal toxicities, increased aminotransferases, alopecia, fatigue, dehydration, rash, infection/sepsis and neuropathy.
Drugi neželeni učinki vključujejo toksičnost za ledvice, povišane aminotransferaze, alopecijo, utrujenost, dehidracijo, izpuščaj, okužbo/sepso in nevropatijo.
The relative treatment effect of pemetrexed was internally consistent across subgroups (including disease stage, induction response, ECOG PS, smoking status, gender, histology and age) and similar to that observed in the unadjusted OS and PFS analyses.
Relativni učinek zdravljenja s pemetreksedom je bil notranje konsistenten med podskupinami (vključno s stopnjo bolezni, odzivom na indukcijsko zdravljenje, stanjem zmogljivosti po ECOG, kajenjem, spolom, histologijo in starostjo) in podoben tistemu, ki so ga opazili pri neprilagojenih analizah skupnega preživetja in preživetja brez napredovanja bolezni.
Uncommon cases of peripheral ischaemia leading sometimes to extremity necrosis have been reported.
Poročali so o občasnih primerih periferne ishemije, ki je včasih vodila v nekrozo okončin.
A Phase 2 study of pemetrexed in 31 solid tumour patients with stable third-space fluid demonstrated no difference in pemetrexed dose normalised plasma concentrations or clearance compared to patients without third-space fluid collections.
V študiji pemetrekseda so v fazi II pri 31 bolnikih s solidnim tumorjem in stabilno tekočino tretjega prostora pokazali, da ni razlike med normalno koncentracijo v plazmi ali očistkom, doseženo glede na odmerek pemetrekseda, v primerjavi z bolniki brez zaloge tekočine tretjega prostora.
Concomitant use contraindicated Yellow fever vaccine: Risk of fatal generalised vaccinale disease (see section 4.3).
Kontraindicirana sočasna uporaba Cepivo proti rumeni mrzlici: tveganje za smrtno generalizirano bolezen po cepljenju (glejte poglavje
Single use only SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN Keep out of the sight and reach of children.
POSEBNO OPOZORILO O SHRANJEVANJU ZDRAVILA ZUNAJ DOSEGA IN POGLEDA OTROK
Concomitant yellow fever vaccine (see section 4.5).
Sočasno cepljenje proti rumeni mrzlici (glejte poglavje 4.5).
There were no clinically relevant differences observed for the safety profile of pemetrexed within the histology subgroups.
Za varnostni profil pemetrekseda niso opazili nobenih klinično pomembnih razlik znotraj histoloških podskupin.
Therefore, patients should receive adequate anti-emetic treatment and appropriate hydration prior to and/or after receiving treatment.
Zato moramo bolnike pred prejemanjem terapije in/ali po njej ustrezno hidrirati, prejeti morajo zadostno antiemetično zdravljenje.
Reconstituted and infusion solutions: When prepared as directed, chemical and physical in-use stability has been demonstrated for 24 hours at refrigerated temperature (2°C to 8°C) and at 25°C.
Rekonstituirane raztopine in raztopine za infundiranje: Če je zdravilo pripravljeno skladno z navodili, so kemijsko in fizikalno obstojnost zdravila med uporabo dokazali za 24 ur pri temperaturi shranjevanja v hladilniku (2°C do 8°C) in pri temperaturi 25 °C.
Clinically relevant Grade 3 and Grade 4 laboratory toxicities were similar between integrated Phase 2 results from three single-agent pemetrexed studies (N = 164) and the Phase 3 single-agent pemetrexed study described above, with the exception of neutropenia (12.8% versus 5.3%, respectively) and alanine aminotransferase elevation (15.2% versus 1.9%, respectively).
Klinično pomembne laboratorijske toksičnosti stopenj 3 in 4 so bile podobne pri integriranih rezultatih faze 2 treh študij pemetrekseda kot edine učinkovine (n = 164) in faze 3 študije pemetrekseda kot edine učinkovine, opisane zgoraj, z izjemo nevtropenije (12,8 % oziroma 5,3 %) in povišanja alaninske aminotransferaze (15,2 % oziroma 1,9 %).
However, patients with hepatic impairment, such as bilirubin > 1.5times the upper limit of normal and/or aminotransferase > 3.0-times the upper limit of normal (hepatic metastases absent) or > 5.0 times the upper limit of normal (hepatic metastases present), have not been specifically studied.
Vendar pa bolnikov z okvarjenim delovanjem jeter, ki se kaže kot bilirubin > 1,5-kratnik zgornje meje normalnih vrednosti in/ali aminotransferaza > 3,0-kratnik zgornje meje normalnih vrednosti (brez zasevkov v jetrih) ali > 5,0-kratnik zgornje meje normalnih vrednosti (z zasevki v jetrih), niso posebej preučevali.
Other (N = 252)
Drugo (N = 252)
Patients must take oral folic acid or a multivitamin containing folic acid (350 to 1,000 micrograms) on a daily basis.
Bolniki morajo dnevno jemati peroralno folno kislino ali multivitaminski pripravek, ki jo vsebuje (350 do 1.000 mikrogramov).
Vitamin supplementation: your doctor will prescribe you oral folic acid (vitamin) or a multivitamin containing folic acid (350 to 1,000 micrograms) that you must take once a day while you are taking Pemetrexed Pfizer.
Dopolnjevanje vitaminov: vaš zdravnik vam bo predpisal peroralno folno kislino (vitamin) ali multivitaminski pripravek, ki jo vsebuje (350 do 1.000 mikrogramov), ki ga boste morali med prejemanjem zdravila Pemetreksed Pfizer jemati enkrat dnevno.
Common ALT (SGPT) elevation
Pogosto Povišanje SGPT (ALT) Povišanje
Discard unused contents appropriately
Neuporabljeno vsebino ustrezno zavrzite.
What Pemetrexed Pfizer is and what it is used for
Kaj je zdravilo Pemetreksed Pfizer in za kaj ga uporabljamo
Pemetrexed Pfizer must only be further diluted with 5% glucose solution, without preservative.
Zdravilo Pemetreksed Pfizer moramo še nadalje redčiti samo s 5-odstotno raztopino glukoze brez konzervansa.
The independent review of patient scans confirmed the findings of the investigator assessment of PFS.
Neodvisni pregled posnetkov bolnikov je potrdil izsledke ocen preživetja brez napredovanja s strani raziskovalca.
The reconstituted solution is clear and ranges in colour from colourless to yellow or green-yellow without adversely affecting product quality.
Rekonstituirana raztopina je bistra, brezbarvna do rumena ali zeleno-rumena, barve v tem razponu ne vplivajo na kakovost zdravila.
As with other potentially toxic anti-cancer agents, care should be exercised in the handling and preparation of pemetrexed infusion solutions.
Kot pri drugih potencialno toksičnih učinkovinah za zdravljenje raka je potrebna previdnost pri ravnanju z raztopinami pemetrekseda za infundiranje ter pripravi teh raztopin.
Pemetrexed Pfizer can be prescribed to you if you have lung cancer at an advanced stage if your disease has responded to treatment or it remains largely unchanged after initial chemotherapy.
Zdravnik vam lahko predpiše zdravilo Pemetreksed Pfizer, če imate pljučnega raka v napredovalem stadiju in če se vaša bolezen odziva na zdravljenje oz. če po začetni kemoterapiji ostaja večinoma nespremenjena.