natgillin/translations-raw huggingface dataset:
The usual starting and maintenance dose is 50 mg once daily for most patients.
Za večino bolnikov je običajen začetni in vzdrževalni odmerek 50 mg enkrat na dan.
At the end of three weeks, losartan administration once daily lowered trough blood pressure in a dose-dependent manner.
Po treh tednih je dajanje losartana enkrat dnevno krvni tlak ob izteku učinka znižalo v odvisnosti od odmerka.
Therefore losartan must not be administered in patients with severe hepatic impairment (see sections 4.2, 4.3 and 5.2).
Zato se losartan ne sme uporabljati pri bolnikih s hudo jetrno okvaro (glejte poglavja 4.2, 4.3 in 5.2).
Do not take Cozaar
Ne jemljite zdravila Cozaar:
Cozaar may be taken with or without food.
Zdravilo Cozaar lahko vzamete s hrano ali na tešče.
Lithuania UAB Merck Sharp & Dohme, Geležinio Vilko 18A,
UAB Merck Sharp & Dohme, Geležinio Vilko 18A, LT- 01112 Vilnius, Litva
Muscoskeletal and connective tissue disorders: not known: back pain
Bolezni mišično-skeletnega sistema in vezivnega tkiva pogostnost ni znana: bolečine v hrbtu
Cozaar may be administered with other antihypertensive agents (e.g. diuretics, calcium channel blockers, alpha- or beta-blockers, and centrally acting agents) as well as with insulin and other commonly used hypoglycemic agents (e.g. sulfonylureas, glitazones and glucosidase inhibitors).
Zdravilo Cozaar se lahko jemlje skupaj z drugimi antihipertenzivnimi zdravili (npr. diuretiki, zaviralci kalcijevih kanalčkov, alfa ali beta zaviralci ter antihipertenzivi z delovanjem na centralni živčni sistem) pa tudi z insulinom in drugimi običajnimi antidiabetičnimi zdravili (npr. sulfonilsečnine, glitazoni in zaviralci glukozidaze).
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER [To be completed nationally]
IME IN NASLOV IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM [Izpolni država članica]
White, oval film-coated tablets marked 952 on one side and scored on the other.
Bele, ovalne filmsko obložene tablete z oznako 952 na eni strani in z razdelilno zarezo na drugi strani.
In elderly hypertensive patients the plasma concentrations of losartan and its active metabolite do not differ essentially from those found in young hypertensive patients.
Plazemske koncentracije losartana in njegovega aktivnega presnovka pri starejših hipertonikih niso pomembno drugačne kot pri mladih hipertonikih.
- Treatment of essential hypertension
- Zdravljenje esencialne hipertenzije
Use in patients with renal impairment and haemodialysis patients: No initial dosage adjustment is necessary in patients with renal impairment and in haemodialysis patients.
Uporaba pri bolnikih z ledvično okvaro in bolnikih na hemodializi Pri bolnikih z ledvično okvaro in bolnikih na hemodializi začetnega odmerka ni treba prilagoditi.
• increase in blood urea,
• povečana količina sečnine v krvi
21 film-coated tablets of 12.5 mg and 7 film-coated tablets of 50 mg losartan potassium.
21 filmsko obloženih tablet z 12,5 mg in 7 filmsko obloženih tablet s 50 mg kalijevega losartanata.
Liver Function Impairment
Okvara ledvične funkcije
Nervous system disorders: uncommon: dizziness, headache rare: paraesthesia
Bolezni živčevja občasne: omotica, glavobol redke: parestezija
PHARMACEUTICAL FORM AND CONTENTS 7, 10, 14, 15, 20, 28, 30, 50, 56, 84, 90, 98, or 280 tablets.
FARMACEVTSKA OBLIKA IN VSEBINA 7, 10, 14, 15, 20, 28, 30, 50, 56, 84, 90, 98 ali 280 tablet.
• if your liver function is severely impaired,
• če imate hudo okvaro jeter.
Treatment with losartan resulted in a 13.0% risk reduction (p=0.021, 95 % confidence interval 0.77-0.98) compared with atenolol for patients reaching the primary composite endpoint.
Zdravljenje z losartanon je v primerjavi z atenololom tveganje za primarni sestavljeni opazovani dogodek zmanjšalo za 13,0 % (p = 0,021; 95-odstotni interval zaupanja 0,77-0,98).
Vascular disorders: common: hypotension
Žilne bolezni pogoste: hipotenzija
SPECIAL STORAGE CONDITIONS Keep the blister in the outer carton.
POSEBNA NAVODILA ZA SHRANJEVANJE Pretisni omot shranjujte v škatli.
Merck Sharp & Dohme Limited Hertford Road, Hoddesdon, Herts EN11 9BU
Merck Sharp & Dohme Limited Hertford Road, Hoddesdon, Herts EN11 9BU, Velika Britanija
Use in pediatric patients with renal function impairment Losartan is not recommended in children with glomerular filtration rate < 30ml/ min/ 1.73 m2as no data are available (see section 4.2).
Uporaba pri pediatričnih bolnikih z okvaro ledvične funkcije Losartana ne priporočamo za uporabo pri otrocih, ki imajo hitrost glomerulne filtracije < 30 ml/min/1,73 m2, ker ni na voljo nobenih podatkov (glejte poglavje 4.2).
happening in 1 in 10,000 to 1 in 1,000 patients very rare:
pojavijo se pri 1 ali več od 10.000 ter manj kot 1 od 1.000 bolnikov zelo redki:
not known:
Pogostnost ni znana:
• somnolence,
• zaspanost
What Cozaar contains
Kaj vsebuje zdravilo Cozaar
The following wording has been added to the Package Leaflet Section 2 Before you take Cozaar: Use in children and adolescents <COZAAR> has been studied in children.
Naslednje besedilo je bilo dodano v poglavje 2 navodil za uporabo „Kaj morate vedeti, preden boste vzeli zdravilo Cozaar“:
21 film-coated tablets of 12.5 mg and 14 film-coated tablets of 50 mg losartan potassium.
21 filmsko obloženih tablet z 12,5 mg in 14 filmsko obloženih tablet s 50 mg kalijevega losartanata.
General disorders and administration site conditions: not known: flu-like symptoms
Splošne težave in spremembe na mestu aplikacije pogostnost ni znana: gripi podobni simptomi
Generally, the dose should be increased weekly step-by-step (i.e., 12.5 mg daily during the first week, 25 mg daily during the second week, 50 mg daily during the third week) up to the usual maintenance dose of 50 mg losartan (one tablet Cozaar 50 mg) once daily, according to your condition.
Zdravljenje se običajno začne z 12,5 mg losartana (ena tableta Cozaar 12,5 mg) enkrat na dan. Večinoma je treba odmerek povečati glede na vaše stanje, postopoma, tedensko (tj. 12,5 mg dnevno prvi teden, 25 mg dnevno drugi teden, 50 mg dnevno tretji teden) do običajnega vzdrževalnega odmerka 50 mg losartana (ena tableta Cozaar 50 mg) enkrat na dan.
Always take Cozaar exactly as your doctor has instructed you.
Pomembno je, da nadaljujete z jemanjem zdravila Cozaar tako dolgo, kot vam je predpisal zdravnik.
Luxembourg Therabel Pharma S.A. - Rue Egide Van Ophem 108
Luksemburg Therabel Pharma S.A. - Rue Egide Van Ophem 108 - B-1180 Bruselj, Belgija
PHARMACEUTICAL FORM AND CONTENTS 7, 10, 14, 20, 28, 30, 50, 56, 84, 90, 98, 280 or 500 tablets.
FARMACEVTSKA OBLIKA IN VSEBINA 7, 10, 14, 20, 28, 30, 50, 56, 84, 90, 98, 280 in 500 tablet.
It is not recommended in children with glomerular filtration rate < 30 ml/ min / 1.73 m2, as no data are available (see also section 4.4).
Uporaba ni priporočljiva pri otrocih s stopnjo glomerularne filtracije < 30 ml/ min / 1,73 m2, saj za to skupino podatki niso na voljo (glejte tudi poglavje 4.4).
The Losartan Intervention For Endpoint Reduction in Hypertension [LIFE] study was a randomised, triple-blind, active-controlled study in 9193 hypertensive patients aged 55 to 80 years with ECGdocumented left-ventricular hypertrophy.
Vključevala je 9.193 hipertenzivnih bolnikov, starih od 55 do 80 let, z EKG-jem potrjeno hipertrofijo levega prekata.
There was also a significant risk reduction for doubling of the serum creatinine and for end-stage renal failure in the patient group treated with losartan.
V skupini bolnikov, zdravljenih z losartanom, je bilo ugotovljeno tudi signifikantno zmanjšanje tveganja za podvojitev serumskega kreatinina ter za napredovanje do končnega stadija ledvične bolezni.
Therefore, losartan is contraindicated in patients with severe hepatic impairment (see sections 4.3 and 4.4).
Zato je uporaba losartana pri bolnikih s hudo okvaro jeter kontraindicirana (glejte poglavji 4.3 in 4.4).
• liver function abnormalities,
• nenormalno delovanje jeter
Common: dizziness, vertigo Uncommon: somnolence, headache, sleep disorders
Bolezni živčevja pogoste: omotica, vrtoglavica občasne: zaspanost, glavobol, motnje spanja
In a clinical study conducted in type 2 diabetic patients with nephropathy, the incidence of hyperkalemia was higher in the group treated with Cozaar as compared to the placebo group (see section 4.8, 'Hypertension and type 2 diabetes with renal disease - Investigations' and ‘Post-marketing experience - Investigations' Therefore, the plasma concentrations of potassium as well as creatinine clearance values should be closely monitored, especially patients with heart failure and a Creatinine Clearance between 30-50 ml/ min should be closely monitored.
V klinični študiji pri bolnikih s sladkorno boleznijo tipa 2 in nefropatijo je bila pojavnost hiperkaliemije večja v skupini, ki je prejemala zdravilo Cozaar, kot v skupini, ki je prejemala placebo (glejte poglavje 4.8: "Hipertenzija in sladkorna bolezen tipa 2 z boleznijo ledvicPreiskave" in "Izkušnje z zdravilom v obdobju trženja - Preiskave").
If your heart failure has been stabilised with an ACE inhibitor you should not be switched to losartan .
Če je srčno popuščanje stabilno ob zdravljenju z zaviralcem ACE, vam zdravnik zdravila ne sme zamenjati za losartan.
Merck Sharp & Dohme GmbH Donau-City-Straße 6
Merck Sharp & Dohme GmbH Donau-City-Straße 6, 1220 Dunaj, Avstrija
Losartan is not recommended in children with glomerular filtration rate < 30ml/ min/ 1.73 m2as no data are available (see section 4.2).
Losartan ni priporočljiv pri otrocih s stopnjo glomerularne filtracije < 30ml/ml/min/1,73 m2, saj o taki uporabi ni na voljo nobenih podatkov (glejte poglavje 4.2).
Cozaar 25 mg tablet
Cozaar 25 mg tablete
Renal and urinary disorders: not known: urinary tract infections
Bolezni sečil pogostnost ni znana: okužbe urinarnega trakta
• numbness or tingling sensation (paraesthesia),
• odrevenelost ali mravljinčenje (parestezija)
Hepatobiliary disorders: rare: hepatitis not known: liver function abnormalities
Bolezni jeter, žolčnika in žolčevodov redke: hepatitis pogostnost ni znana: nenormalno delovanje jeter
Ireland Merck Sharp & Dohme Limited Hertford Road, Hoddesdon, Herts EN11 9BU
Velika Britanija Merck Sharp & Dohme Limited Hertford Road, Hoddesdon, Herts EN11 9BU, Velika Britanija
INFORMATION IN BRAILLE [To be completed nationally] [For referral procedures]
PODATKI V BRAILLOVI PISAVI [Izpolni država članica]
Each Cozaar 100 mg tablet contains 51.0 mg lactose monohydrate.
Vsaka Cozaar 100 mg tableta vsebuje 51,0 mg laktoze monohidrata.
Respiratory, thoracic and mediastinal disorders: not known: cough
Bolezni dihal, prsnega koša in mediastinalnega prostora pogostnost ni znana: kašelj
A low dose of hydrochlorothiazide should be added and/ or the dose of Cozaar should be increased to 100 mg once daily based on blood pressure response.
Običajni začetni odmerek je 50 mg zdravila Cozaar enkrat na dan. Glede na odziv krvnega tlaka je treba dodati majhen odmerek hidroklorotiazida in/ali odmerek zdravila Cozaar povečati na 100 mg enkrat na dan.
Both biliary and urinary excretion contribute to the elimination of losartan and its metabolites.
K izločanju losartana in njegovih presnovkov prispevata tako izložanje z žolčem kot izložanje preko ledvic.
• muscle and joint pain,
• bolečine v mišicah in sklepih
Unless continued ARB therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.
Pri bolnicah, ki načrtujejo nosečnost, je treba čimprej preiti na alternativno antihipertenzivno zdravljenje z uveljavljenim varnostnim profilom za uporabo v nosečnosti; razen, če se oceni, da je nadaljnje zdravljenje z AIIA-jem nujno.
Gastrointestinal disorders: not known: diarrhoea
Bolezni prebavil pogostnost ni znana: diareja
Store Cozaar in the original package.
Zdravilo Cozaar shranjujte v originalni ovojnini.
Cozaar 100 mg filmdragerade tabletter United Kingdom COZAAR 50 MG FILM-COATED TABLETS United Kingdom COZAAR 25 MG FILM-COATED TABLETS United Kingdom COZAAR 100MG FILM-COATED TABLETS Iceland
Velika Britanija COZAAR 50 MG FILM-COATED TABLETS Velika Britanija COZAAR 25 MG FILM-COATED TABLETS
General disorders and administration site conditions: common: asthenia/fatigue
Splošne težave in spremembe na mestu aplikacije pogoste: astenija/utrujenost
Each Cozaar 100 mg tablet contains 100 mg of losartan potassium.
Vsaka Cozaar 100 mg tableta vsebuje 100 mg kalijevega losartanata.
Unless continued losartan therapy is considered essential, patients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancy.
Pri bolnicah, ki načrtujejo nosečnost, je treba čimprej preiti na alternativno antihipertenzivno zdravljenje z uveljavljenim varnostnim profilom za uporabo v nosečnosti; razen, če se oceni, da je nadaljnje zdravljenje z losartanom nujno.
The Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan RENAAL study was a controlled clinical study conducted worldwide in 1513 Type 2 diabetic patients with proteinuria, with or without hypertension.
Študija RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan; Zmanjšanje števila opazovanih dogodkov z antagonistom angiotenzina II losartanom pri od insulina neodvisni sladkorni bolezni) je bila kontrolirana klinična študija.
Blue, oval film-coated tablets marked 11 on one side and plain on the other.
Cozaar 12,5 mg tablete Modre, ovalne filmsko obložene tablete, z oznako 11 na eni strani in brez oznake na drugi strani.
Skin and subcutanous tissue disorders: uncommon: urticaria, pruritus, rash
Bolezni kože in podkožja pogostnost ni znana: urtikarija, srbenje, izpuščaj
Losartan is also not recommended in children with hepatic impairment (see also section 4.4).
Losartan prav tako ni priporočljiv pri otrocih z okvaro jeter (glejte tudi poglavje 4.4).
NAME OF THE MARKETING AUTHORISATION HOLDER [See Annex I - To be completed nationally]
IME IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM [Glejte Dodatek 1 - Izpolni država članica]
The antihypertensive effect of Cozaar was established in a clinical study involving 177 hypertensive paediatric patients 6 to 16 years of age with a body weight > 20 kg and a glomerular filtration rate > 30 ml/ min/ 1.73 m2.
Antihipertenzivni učinek zdravila Cozaar je bil določen v klinični študiji, ki je vključevala 177 hipertenzivnih pediatričnih bolnikov, starih 6 do 16 let, s telesno maso > 20 kg in stopnjo glomerularne filtracije > 30 ml/min/1,73 m2. Bolniki, ki so tehtali >20 kg do < 50 kg, so prejemali 2,5, 25 ali 50 mg losartana dnevno, bolniki, ki so tehtali > 50 kg, pa so prejemali 5, 50 ali 100 mg losartana dnevno.
Cozaar is used
Zdravilo Cozaar se uporablja:
Each Cozaar 12.5 mg Tablet contains 12.5 mg of losartan (as potassium salt).
Vsaka Cozaar 12,5 mg tableta vsebuje 12,5 mg losartana (v obliki kalijeve soli).
The dose should generally be titrated at weekly intervals (i.e. 12.5 mg daily, 25 mg daily, 50 mg daily) to the usual maintenance dose of 50 mg once daily, as tolerated by the patient.
Običajni začetni odmerek zdravila Cozaar pri bolnikih s srčnim popuščanjem je 12,5 mg enkrat na dan. Odmerek je običajno treba titrirati tedensko (to je 12,5 mg na dan, 25 mg na dan, 50 mg na dan) do običajnega vzdrževalnega odmerka 50 mg enkrat na dan, glede na to, kako bolnik zdravilo prenaša.
Filmcoated tablet Oral use
Filmsko obložena tableta Peroralna uporaba
The dose may later be increased to 100 mg losartan (two tablets Cozaar 50 mg) once daily depending on your blood pressure response.
Zdravljenje se običajno začne s 50 mg losartana (ena tableta Cozaar 50 mg) enkrat na dan. Odmerek se kasneje lahko poveča na 100 mg losartana (dve tableti Cozaar 50 mg) enkrat na dan, glede na odziv krvnega tlaka.
The CHMP was concerned that the benefit/risk ratio of this indication could not be adequately established.
- Srčno popuščanje (kot druga izbira, ko zaviralci ACE niso primerni) CHMP je izrazil pomislek, da razmerja med tveganji in koristmi za to indikacijo ni mogoče ustrezno določiti.
Each Cozaar 12.5 mg tablet contains 12.5 mg of losartan potassium.
Vsaka Cozaar 12,5 mg tableta vsebuje 12,5 mg kalijevega losartanata.
Cozaar 12.5 mg - PVC/PE/PVDC blister packages with aluminum foil lidding in packs of 7, 14, 21, 28, 50, 98, 210 or 500 tablets.
Cozaar 12,5 mg: PVC/PE/PVDC pretisni omoti s prevleko iz aluminijaste folije v pakiranjih po 7, 14, 21, 28, 50, 98, 210 ali 500 tablet.
GROUNDS FOR AMENDMENT OF THE SUMMARIES OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET
PODLAGA ZA DOPOLNILO POVZETKA GLAVNIH ZNAČILNOSTI ZDRAVILA, OZNAČEVANJA IN NAVODILA ZA UPORABO
It is important to tell your doctor before taking Cozaar:
KAJ MORATE VEDETI, PREDEN BOSTE VZELI ZDRAVILO COZAAR
Losartan is also not recommended in children with hepatic impairment (see section 4.2).
Losartan prav tako ni priporočljiv pri otrocih z okvaro jeter (glejte tudi poglavje 4.2).
happening in 1 in 100 to 1 in 10 patients uncommon happening in 1 in 1,000 to 1 in 100 patients rare:
pojavijo se pri 1 ali več od 1.000 ter manj kot 1 od 100 bolnikov redki:
Hypertensive type II diabetic patients with proteinuria ≥ 0.5 g/day The usual starting dose is 50 mg once daily.
Bolniki s hipertenzijo in sladkorno boleznijo tipa 2 s proteinurijo ≥ 0,5 g/dan Običajni začetni odmerek je 50 mg enkrat na dan. Glede na odziv krvnega tlaka lahko po enem mesecu zdravljenja ali kasneje odmerek povečamo na 100 mg enkrat na dan.
The side effects of medicines are classified as follows: very common: happening in more than 1 in 10 patients common:
Neželeni učinki so razvrščeni takole: zelo pogosti:
Read all of this leaflet carefully before taking this medicine.
Pred uporabo natančno preberite navodilo!
HOW TO STORE Cozaar
SHRANJEVANJE ZDRAVILA COZAAR
Each Cozaar 25 mg tablet contains 25 mg of losartan potassium.
Vsaka Cozaar 25 mg tableta vsebuje 25 mg kalijevega losartanata.
Blister for Cozaar 12.5 mg film-coated tablets Blister for Cozaar 50 mg film-coated tablets
Pretisni omot za Cozaar 12,5 mg filmsko obložene tablete Pretisni omot za Cozaar 50 mg filmsko obložene tablete
Each Cozaar 25 mg Tablet contains 25 mg of losartan (as potassium salt).
Vsaka Cozaar 25 mg tableta vsebuje 25 mg losartana (v obliki kalijeve soli).
STATEMENT OF ACTIVE SUBSTANCE(S) Each Cozaar 12.5 mg film-coated mg tablet contains 12.5 mg losartan potassium.
NAVEDBA ENE ALI VEČ ZDRAVILNIH UČINKOVIN Vsaka COZAAR 12,5 mg filmsko obložena tableta vsebuje 12,5 mg kalijevega losartanata.
Nervous system disorders: common: dizziness
Bolezni živčevja pogoste: omotica
The Cozaar 12.5 mg tablets also may contain carnauba wax (E903), titanium dioxide (E171), indigo carmine (E132) aluminum lake.
Cozaar 12,5 mg tablete lahko vsebujejo še karnauba vosek (E903), titanov dioksid (E171), indigo karmin (E132).
The following adverse events occurred more often in patients receiving losartan than placebo: Blood and lymphatic system disorders: not known: anaemia
Naslednji neželeni učinki so se pogosteje pojavili pri bolnikih, ki so prejemali losartan, kot pri bolnikih, ki so prejemali placebo:
Each Cozaar 50 mg film-coated mg tablet contains 50 mg losartan potassium.
Vsaka COZAAR 50 mg filmsko obložena tableta vsebuje 50 mg kalijevega losartanata.
Each Cozaar 12,5 mg tablet contains 25.5 mg lactose monohydrate.
Vsaka Cozaar 12,5 mg tableta vsebuje 25,5 mg laktoze monohidrata.
LORTAAN 100mg
100mg
Cozaar is supplied as unscored film-coated tablets containing 25 mg of losartan potassium.
Zdravilo Cozaar je na voljo v obliki filmsko obloženih tablet brez razdelilne zareze, ki vsebujejo 25 mg kalijevega losartanata.
A lower dose should be considered for patients with a history of hepatic impairment.
Pri bolnikih, ki so kdaj imeli okvaro jeter, je treba razmisliti o manjšem odmerku.
Each Cozaar 50 mg Tablet contains 50 mg of losartan (as potassium salt).
Vsaka Cozaar 50 mg tableta vsebuje 50 mg losartana (v obliki kalijeve soli).
• migraine,
• migrena
Each Cozaar 50 mg tablet contains 25.5 mg lactose monohydrate.
Vsaka Cozaar 50 mg tableta vsebuje 25,5 mg laktoze monohidrata.
Luxembourg Merck Sharp & Dohme BVChaussée de Waterloo 1135
Luksemburg Merck Sharp & Dohme BV -Chaussée de Waterloo 1135 - B-1180 Bruselj, Belgija
Cozaar is supplied as unscored film-coated tablets containing 100 mg of losartan potassium.
Zdravilo Cozaar je na voljo v obliki filmsko obloženih tablet brez razdelilne zareze, ki vsebujejo 100 mg kalijevega losartanata.
Gastrointestinal disorders: uncommon: diarrhoea, nausea, vomiting
Bolezni prebavil občasne: diareja, navzeja, bruhanje
White, teardrop-shaped film-coated tablets marked 960 on one side and plain on the other.
Bele, filmsko obložene tablete v obliki kapljice, z oznako 951 na eni strani in brez oznake na drugi strani.
Investigators were instructed to titrate the study medication to 100 mg daily as appropriate; 72 % of patients were taking the 100 mg daily dose for the majority of the time.
Raziskovalci so dobili navodila, naj odmerek preiskovanega zdravila titrirajo do 100 mg enkrat na dan, če je potrebno.
• shortness of breath (dyspnoea),
• kratka sapa (dispneja)
• nausea,
• bruhanje
Each Cozaar 50 mg tablet contains 50 mg of losartan potassium.
Vsaka Cozaar 50 mg tableta vsebuje 50 mg kalijevega losartanata.
Each Cozaar 100 mg Tablet contains 91 100 mg of losartan (as potassium salt).
Vsaka Cozaar 100 mg tableta vsebuje 100 mg losartana (v obliki kalijeve soli).
751 Patients were treated with Losartan The objective of the study was to demonstrate a nephroprotective effect of Losartan potassium over and above the benefit of a blood lowering pressure.
Namen študije je bil poleg koristi za znižanje krvnega tlaka pokazati še zaščitni učinek kalijevega losartanata na ledvice.
Cozaar is supplied as scored film-coated tablets containing 50 mg of losartan potassium.
Zdravilo Cozaar je na voljo v obliki filmsko obloženih tablet z razdelilno zarezo, ki vsebujejo 50 mg kalijevega losartanata.
happening in less than 1 in 10,000 patients not known
pojavijo se pri manj kot 1 od 10.000 bolnikov neznana pogostnost: (iz razpoložljivih podatkov se ne da oceniti)
Each Cozaar 25 mg tablet contains12.75 mg lactose monohydrate.
Vsaka Cozaar 25 mg tableta vsebuje 12,75 mg laktoze monohidrata.
What Cozaar looks like and contents of the pack Cozaar is supplied as unscored film-coated tablets containing 12.5 mg of losartan potassium.
Zdravilo Cozaar je na voljo v obliki filmsko obloženih tablet brez razdelilne zareze, ki vsebujejo 12,5 mg kalijevega losartanata.
In the LIFE-Study black patients treated with Losartan had a higher risk of suffering the primary combined endpoint, i.e. a cardiovascular event (e.g. cardiac infarction, cardiovascular death) and especially stroke, than the black patients treated with atenolol.
V študiji LIFE so imeli bolniki črne rase, zdravljeni z losartanom, večje tveganje za primarni sestavljeni opazovani dogodek, t.j.
• Treatment of renal disease in patients with hypertension and type 2 diabetes mellitus with proteinuria ≥ 0.5 g/day as part of an antihypertensive treatment.
• Zdravljenje bolezni ledvic pri bolnikih s hipertenzijo in sladkorno boleznijo tipa 2 s proteinurijo
PARTICULARS TO APPEAR ON THE OUTER PACKAGING Bottle label for Cozaar 12.5 mg HDPE bottle
PODATKI NA ZUNANJI OVOJNINI Škatla s HDPE plastenko za Cozaar 12,5 mg
Film-coated tablets
Filmsko obložene tablete.
White, oval unscored film-coated tablets marked 951 on one side and plain on the other.. Cozaar 50 mg tablet
Bele, ovalne filmsko obložene tablete brez razdelilne zareze, z oznako 951 na eni strani in brez oznake na drugi strani.
Cozaar contains lactose monohydrate.
Pomembne informacije o nekaterih sestavinah zdravila Cozaar Zdravilo Cozaar vsebuje laktozo monohidrat.
The Cozaar 100 mg tablets also may contain Carnauba wax (E903), Titanium dioxide (E171).
Cozaar 100 mg tablete lahko vsebujejo še karnauba vosek (E903), titanov dioksid (E171).
Merck Sharp & Dohme Ltd., Hertford Road, Hoddesdon, Hertfordshire EN11 9BU United Kingdom
Merck Sharp & Dohme Ltd., Hertford Road, Hoddesdon,
PARTICULARS TO APPEAR ON THE OUTER PACKAGING Bottle label for Cozaar 100 mg HDPE Bottle
PODATKI NA ZUNANJI OVOJNINI Škatla s HDPE plastenko za Cozaar 100 mg