natgillin/translations-raw huggingface dataset:
• cimetidine (used to treat stomach ulcers)
• cimetidin (uporablja se za zdravljenje želodčnih razjed)
In vitro the metabolism of amitriptyline proceeds mainly by demethylation (CYP2C19, CYP3A) and hydroxylation (CYP2D6) followed by conjugation with glucuronic acid.
Presnova amitriptilina in vitro poteka pretežno z demetilacijo (CYP2C19, CYP3A) in hidroksilacijo (CYP2D6), katerima sledi konjugacija z glukuronsko kislino.
Treatment of the following will be decided on a case by case basis: - Wide QRS-intervals, cardiac failure and ventricular arrhythmias - Circulatory failure - Hypotension - Hyperthermia - Convulsions - Metabolic acidosis.
Zdravljenje naslednjih stanj se razlikuje od primera do primera: - razširjeni interval QT, srčna odpoved in ventrikualrne aritmije - cirkulatorni kolaps - hipotenzija - hipertermija - konvulzije - metabolna acidoza
• if you have taken MAOIs within the last 14 days
• če ste v zadnjih 14 dneh jemali zaviralce monoaminooksidaze
Polymorphism The metabolism is subject to genetic polymorphism (CYP2D6 and CYP2C19) (see section 4.2).
Polimorfizem Presnova je odvisna od genetskega polimorfizma (CYP2D6 in CYP2C19) (glejte poglavje 4.2).
Suicidal thoughts and behaviours may also develop during early treatment with antidepressants for disorders other than depression; the same precautions observed when treating patients with depression should therefore be followed when treating patients with enuresis.
V zgodnjem obdobju zdravljenja z antidepresivi za druge motnje kot depresijo se lahko pojavijo samomorilne misli in samomorilno vedenje, zato je treba pri zdravljenju bolnikov z enurezo upoštevati enake previdnostne ukrepe kot pri zdravljenju bolnikov z depresijo.
In vitro the metabolism of amitriptyline proceeds mainly by demethylation (CYP2C19, CYP3A4) and hydroxylation (CYP2D6) followed by conjugation with glucuronic acid.
Presnova amitriptilina in vitro poteka pretežno z demetilacijo (CYP2C19, CYP3A4) in hidroksilacijo (CYP2D6), katerima sledi konjugacija z glukuronsko kislino.
• uncontrolled movements
• nenadzorovane gibe
Unless prescribed otherwise adults will receive half an ampoule up to 2 ampoules (1 to 4 ml solution for injection, equivalent to 25 to 100 mg amitriptyline hydrochloride per day) in several single injections of no more than 25 mg amitriptyline hydrochloride.
Če ni predpisano drugače, prejme odrasel bolnik od pol ampule do 2 ampuli (1 do 4 ml raztopine za injiciranje, kar ustreza od 25 do 100 mg amitriptilinijevega klorida na dan) v več posameznih injekcijah po največ 25 mg amitriptilinijevega klorida.
• medicines to treat irregular heartbeats (e.g. quinidine and sotalol)
• zdravila za zdravljenje nepravilnega bitja srca (npr. kinidin in sotalol)
• movement disorders (involuntary movements or decreased movements)
• motnje gibanja (nehoteni gibi ali zmanjšano gibanje)
Not known Anorexia, elevation or lowering of blood sugar levels.
Presnovne in prehranske motnje redki zmanjšan apetit neznana pogostnost anoreksija, zvišanje ali znižanje ravni krvnega sladkorja
The dosing scheme and treatment duration given for the oral formulation should be followed from henceforward.
V tem obdobju je treba upoštevati shemo odmerjanja in trajanje zdravljenja za peroralno obliko.
Reduced renal function This medicinal product can be given in usual doses to patients with renal failure.
To zdravilo se lahko bolnikom z ledvično odpovedjo daje v običajnih odmerkih.
If you receive doses above 75 mg daily, your doctor may need to do more frequent follow-up with you.
Če prejemate odmerke večje od 75 mg na dan, bodo morda potrebni pogostejši zdravniški pregledi.
Consider to monitor TCA plasma levels, whenever a TCA is to be co-administered with another drug known to be an inhibitor of CYP2D6.
Razmislite o spremljanju ravni TCA v plazmi, ko se TCA dajejo sočasno z drugim zdravilom, za katerega je znano,
Pharmacotherapeutic group
Farmakoterapevtska skupina
Longer half-lives and decreased oral (Clo) clearance values due to a reduced rate of metabolism have been demonstrated in elderly patients.
Pri starejših bolnikih so bile razpolovne dobe daljše, vrednosti peroralnega (Clo) očistka pa zmanjšane zaradi zmanjšane hitrosti presnove.
Amitriptyline hydrochloride
amitriptilinijev klorid
Initially 25 mg 2 times daily (50 mg daily).
Začetni odmerek je 25 mg dvakrat na dan (50 mg na dan).
• cisapride (used to treat certain types of indigestion)
• cisaprid (uporablja se za zdravljenje prebavnih težav)
The excretion proceeds mainly with urine.
Izločanje poteka pretežno s sečem.
If you receive doses in the range of 100 mg - 150 mg in the evening, your doctor may need to do more frequent follow-up with you.
Če prejemate odmerke od 100 mg - 150 mg zvečer, bodo morda potrebni pogostejši zdravniški pregledi.
What you need to know before you are given Saroten solution for injection How you will be given X
Kaj je zdravilo X in za kaj ga uporabljamo Kaj morate vedeti, preden vam bodo dali zdravilo Saroten raztopina za injiciranje Kako boste prejeli zdravilo X
Depending on your response to the medicine, your doctor may gradually increase the dose to 150 mg in the evening.
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča do 150 mg zvečer.
• acute increase of pressure in the eye
• akutno zvišanje očesnega tlaka
Elderly patients Longer half-lives values due to a reduced rate of metabolism have been demonstrated in elderly patients.
Starejši bolniki Pri starejših bolnikih so bile razpolovne dobe daljše zaradi zmanjšane hitrosti presnove.
<[Saroten and associated names prolonged-release capsules, hard ] Film-coated tablets
<[Saroten in povezana imena trde kapsule s podaljšanim sproščanjem] Filmsko obložene tablete
<[Saroten and associated names 75 mg, modified release tablets] Amitriptyline hydrochloride>
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem] amitriptilinijev klorid>
• Neuropathic pain in adults
• nevropatske bolečine pri odraslih
For amitriptyline only limited clinical data are available regarding exposed pregnancies.
Na voljo je malo kliničnih podatkov o izpostavljenosti amitriptilinu med nosečnostjo.
• increased pressure in the eye ball
• zvišan tlak v zrklu
<[Saroten and associated names prolonged-release capsules, hard] X contains sucrose
<[Saroten in povezana imena trde kapsule s podaljšanim sproščanjem] Zdravilo X vsebuje saharozo
Arrhythmia.
hipokaliemija.
Take the container of this medicine with you if you go to a doctor or hospital.
K zdravniku ali v bolnišnico vzemite tudi škatlo tega zdravila.
6.3 Shelf life [To be completed nationally] 6.4 Special precautions for storage [To be completed nationally] 6.5 Nature and contents of container [To be completed nationally] 6.6 Special precautions for disposal No special requirements for disposal.
6.6 Posebni varnostni ukrepi za odstranjevanje Ni posebnih zahtev za odstranjevanje.
Pharmacotherapeutic group: Antidepressants - Non-selective monoamine reuptake inhibitor (tricyclic antidepressant)
Antidepresivi - neselektivni zaviralci privzema monoaminov (triciklični antidepresivi)
What you need to know before you take X 3.
Kaj morate vedeti, preden boste vzeli zdravilo X Ne jemljite zdravila X:
• difficulties passing urine
• težave z uriniranjem
Cardiac arrhythmias and severe hypotension are likely to occur with high dosage.
Pri velikih odmerkih se lahko pojavijo srčne aritmije in huda hipotenzija.
Depending on the response to the medicine, your doctor may gradually increase the dose to 150 mg per day divided in two doses.
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča do 150 mg na dan, razdeljeno na dva odmerka.
The mean systemic clearance (Cls) is 39.24±10.18 L/h, range 24.53-53.73 L/h.
Povprečni sistemski očistek (Cls) je 39,24 ± 10,18 l/h, razpon 24,53 - 53,73 l/h.
X can be added to an infusion or injected into a big muscle.
Zdravilo X se lahko doda infuziji ali injicira v veliko mišico (i.m.
• the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products.
• zdravljenje nočne enureze pri otrocih, starih 6 let in več, ko je bila organska patologija, vključno s spino bifido in podobnimi stanji, izključena in ki se niso odzvali na zdravljenje z zdravili, vključno s spazmolitiki in vazopresinu sorodnimi zdravili, ali druga zdravljenja brez zdravil.
If you receive doses in the range of 100 mg - 150 mg, your doctor may need to do more frequent follow-up with you.
Če prejemate odmerke od 100 mg - 150 mg, bodo morda potrebni pogostejši zdravniški pregledi.
Intravenous infusion
Intravensko infundiranje
Film-coated tablets <[Saroten and associated names 10 mg film-coated tablets, Saroten and associated names 25 mg filmcoated tablets]
Filmsko obložene tablete <[Saroten in povezana imena 10 mg filmsko obložene tablete, Saroten in povezana imena 25 mg filmsko obložene tablete]
• heart muscle disease
• obolenje srčne mišice
The appropriate formulation/strength should be selected for the starting doses and any subsequent dose increases.
Za začetne odmerke in vsa nadaljnja zvečanja odmerkov je treba izbrati ustrezno obliko/jakost zdravila.
<[Saroten and associated names 50 mg film-coated tablets] Saroten and associated names 50 mg film-coated tablets are dividable tablets with three score lines.
<[Saroten in povezana imena 50 mg filmsko obložene tablete] Zdravilo Saroten in povezana imena 50 mg filmsko obložene tablete so deljive tablete s tremi razdelilnimi zarezami.
In patients with the rare condition of shallow anterior chamber and narrow chamber angle, attacks of acute glaucoma due to dilation of the pupil may be provoked.
Pri bolnikih z redko boleznijo plitvega sprednjega prekata očesa in ozkega zakotja lahko zaradi razširjenja zenic povzroči akutni glavkom.
Your doctor will give you Saroten solution for injection.
Zdravilo Saroten raztopino za injiciranje vam bo dal zdravnik.
Other isozymes involved are CYP1A2 and CYP2C9.
Druga dva izoencima, ki sodelujeta pri presnovi sta CYP1A2 in CYP2C9.
<[Saroten and associated names 75 mg, modified release tablets, Saroten and associated names 2 ml, 50 mg solution for injection]
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem, Saroten in povezana imena 2 ml, 50 mg raztopina za injiciranje] amitriptilinijev klorid>
• sedatives (e.g. babiturates)
• pomirjevala (npr. babiturati)
An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome.
Nočna enureza Pred uvedbo zdravljenja z amitriptilinom je treba narediti EKG, da se izključi sindrom podaljšanega intervala QT.
Depending on your response to the medicine, your doctor may gradually increase the dose to a total daily dose of 100 mg divided in two doses.
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča do skupnega dnevnega odmerka 100 mg, razdeljenega na dva odmerka.
• particular forms of abnormal heart rhythm (so called torsades de pointes)
• določene oblike nenormalnega srčnega ritma (t.i. torsade de pointes) • alergijsko vnetje pljučnih mešičkov in pljučnega tkiva
The recommended daily dose is 25 mg - 75 mg.
Priporočeni dnevni odmerek je 25 mg - 75 mg.
• An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome
• Pred uvedbo zdravljenja z amitriptilinom je treba narediti EKG, da se izključi sindrom podaljšanega intervala QT.
Unless prescribed otherwise, adult patients receive 1 ampoule Saroten 2 ml (50 mg amitriptyline hydrochloride) in 250 to 500 ml sodium chloride solution 0.9% for 2-3 hours as a drip infusion under control of blood pressure and ECG.
Če ni predpisano drugače, prejme odrasel bolnik 1 ampulo zdravila Saroten 2 ml (50 mg amitriptilinijevega klorida) v 250 do 500 ml 0,9 % raztopine natrijevega klorida v obliki 2 do 3urne kapalne infuzije.
Saroten and associated names (see Annex I) 25 mg prolonged-release capsules, hard Amitriptyline Saroten and associated names (see Annex I) 50 mg prolonged-release capsules, hard Amitriptyline Saroten and associated names (see Annex I) 75 mg modified-release tablet Amitriptyline hydrochloride
Saroten in povezana imena (glejte Prilogo I) 25 mg trde kapsule s podaljšanim sproščanjem amitriptilin Saroten in povezana imena (glejte Prilogo I) 50 mg trde kapsule s podaljšanim sproščanjem amitriptilin Saroten in povezana imena (glejte Prilogo I) 75 mg tablete s prirejenim sproščanjem amitriptilinijev klorid
• swelling of the salivary glands
• otekle žleze slinavke
Those parts currently not needed can be stored in the reservoir of the tablet box (under the slide of the closure), until the next administration.>
Deli, ki trenutno niso potrebni, se lahko do naslednjega dajanja shranijo v predalčku škatle za tablete (pod drsnim delom zaporke).>
• Bed-wetting at night in children aged 6 years and above, only when organic causes, such as spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including muscle relaxants and desmopressin.
• nočnega močenja postelje pri otrocih, starih 6 let in več, pri katerih so bili organski vzroki, kot sta spina bifida in podobna stanja, izključeni in ki se niso odzvali na zdravljenje z zdravili, tudi z mišičnimi relaksanti in dezmopresinom, in druga zdravljenja brez zdravil.
• blue discolouration of the skin
• pomodrelost kože
Clinically relevant interactions may be expected with concomitant use of amitriptyline and strong CYP3A4 inhibitors such as ketoconazole, itraconazole and ritonavir.
Pri sočasni uporabi amitriptilina in močnih zaviralcev CYP3A4, kot so ketokonazol, itrakonazol in ritonavir, so možne klinično pomembne interakcije.
Package leaflet: Information for the patient Saroten and associated names 2 ml, 50 mg solution for injection Amitriptyline hydrochloride
Navodilo za uporabo Saroten in povezana imena 2 ml, 50 mg raztopina za injiciranje amitriptilinijev klorid
Unless prescribed otherwise adults will receive their daily dosages in 250 to 500 ml sodium chloride solution 0.9% for 2-3 hours as a drip infusion under control of blood pressure and ECG.
Če ni predpisano drugače, prejmejo odrasli dnevne odmerke v 250 do 500 ml 0,9 % raztopine natrijevega klorida v obliki 2 do 3-urne kapalne infuzije.
Prolonged QT interval A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG) and heart rhythm disorders (rapid or irregular heart beat) have been reported with X. Tell your doctor if you:
Pri zdravljenju z zdravilom X so poročali o težavah s srcem, imenovanih »podaljšanje intervala QT« (to je vidno na elektrokardiogramu, EKG) in o motnjah srčnega ritma (hitro ali nepravilno bitje srca).
• dilated pupils
• razširjene zenice
• have an over active thyroid gland or receive thyroid medication.
• če imate preveč aktivno ščitnico ali prejemate zdravila za zdravljenje bolezni ščitnice.
Those parts currently not needed can be stored in the reservoir of the tablet box (under the slide of the closure), until the next administration.
Deli, ki trenutno niso potrebni, se lahko do naslednjega dajanja shranijo v predalčku škatle za tablete (pod drsnim delom zaporke).
The tablets should be swallowed with water independent of meals.>
Tablete je treba pogoltniti z vodo, ne glede na obroke hrane.> Prenehanje zdravljenja
• tramadol (painkiller)
• tramadol (zdravilo za lajšanje bolečin)
Stopping treatment with Saroten solution for injection Your doctor will decide when and how to stop your treatment to avoid any unpleasant symptoms that might occur if it is stopped abruptly (e.g. headache, feeling unwell, sleeplessness and irritability).
Zdravnik se bo odločil, kdaj in kako boste prenehali zdravljenje, da se prepreči pojav morebitnih neprijetnih simptomov, ki se lahko pojavijo pri nenadnem prenehanju (npr. glavobol, slabo počutje,
How to store Saroten solution for injection Keep this medicine out of the sight and reach of children.
Shranjevanje zdravila Saroten raztopina za injiciranje Zdravilo shranjujte nedosegljivo otrokom!
<[Saroten and associated names 75 mg, modified release tablets] Due to the two score lines the Saroten and associated names 75 mg can be divided into three parts.
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem] Zaradi dveh razdelilnih zarez je možno tableto zdravila Saroten in povezana imena 75 mg razdeliti na tri dele.
Uncommon (> 1/1,000, < 1/100);
Občasni (> 1/1.000, < 1/100);
Saroten and associated names 10 mg film-coated tablets Saroten and associated names 25 mg film-coated tablets Saroten and associated names 50 mg film-coated tablets
Saroten in povezana imena 10 mg filmsko obložene tablete Saroten in povezana imena 25 mg filmsko obložene tablete Saroten in povezana imena 50 mg filmsko obložene tablete
<[Saroten and associated names 50 mg film-coated tablets] X are dividable tablets with three score lines.
<[Saroten in povezana imena 50 mg filmsko obložene tablete] Zdravilo X so deljive tablete s tremi razdelilnimi zarezami.
NAME OF THE MEDICINAL PRODUCT Saroten and associated names 25 mg prolonged-release capsules, hard Saroten and associated names 50 mg prolonged-release capsules, hard Saroten and associated names 75 mg, modified release tablets
Saroten in povezana imena 25 mg trde kapsule s podaljšanim sproščanjem Saroten in povezana imena 50 mg trde kapsule s podaljšanim sproščanjem Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem
Reduced hepatic function
Zmanjšano delovanje ledvic
This medicine is taken every evening as a single daily dose.
Kdaj in kako jemati zdravilo X To zdravilo se jemlje enkrat na dan vsak večer.
<[Saroten and associated names 75 mg, modified release tablets] Saroten retard Tabs 75 mg are dividable retard tablets with two score lines.
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem] Zdravilo Saroten retard tablete 75 mg so deljive tablete s prirejenim sproščanjem z dvema razdelilnima zarezama.
<[Saroten and associated names prolonged-release capsules, hard] The capsules should be swallowed with water.
<[Saroten in povezana imena trde kapsule s podaljšanim sproščanjem] Kapsule pogoltnite z vodo.
INFORMATION IN BRAILLE [To be completed nationally] UNIQUE IDENTIFIER - 2D BARCODE Not applicable.
EDINSTVENA OZNAKA - DVODIMENZIONALNA ČRTNA KODA Navedba smiselno ni potrebna.
PHARMACEUTICAL PARTICULARS 6.1 List of excipients [To be completed nationally] 6.2 Incompatibilities Not applicable.
6.2 Inkompatibilnosti Navedba smiselno ni potrebna.
Saroten and associated names (see Annex I) 10 mg film-coated tablets Saroten and associated names (see Annex I) 25 mg film-coated tablets Saroten and associated names (see Annex I) 50 mg film-coated tablets
Saroten in povezana imena (glejte Prilogo I) 10 mg filmsko obložene tablete Saroten in povezana imena (glejte Prilogo I) 25 mg filmsko obložene tablete Saroten in povezana imena (glejte Prilogo I) 50 mg filmsko obložene tablete amitriptilin
If necessary the dose can be increased by 25 mg or 50 mg after 1 week up to 150 mg daily.
Po potrebi se lahko odmerek po 1 tednu poveča po 25 mg ali
If you receive doses above 100 mg daily, your doctor may need to do more frequent follow-up with you.
Če prejemate odmerke večje od 100 mg na dan, bodo morda potrebni pogostejši zdravniški pregledi.
The initial dose should be 10 mg - 25 mg in the evening.
Začetni odmerek mora biti 10 mg - 25 mg zvečer.
Saroten and associated names is indicated for in-hospital treatment of major depressive disorders in adults.
4.1 Terapevtske indikacije Zdravilo X je indicirano za bolnišnično zdravljenje hudih depresij pri odraslih.
Antidepressants - Non-selective monoamine reuptake inhibitor (tricyclic antidepressant) ATC code: N 06 AA 09
5.1 Farmakodinamične lastnosti Farmakoterapevtska skupina: Antidepresivi - neselektivni zaviralci privzema monoaminov (triciklični antidepresivi), Oznaka ATC: N06AA09 Mehanizem delovanja
Rare side effect, may affect up to 1 in 1,000 people.
Redek neželeni učinek; pojavi se lahko pri največ 1 od 1.000 bolnikov.
Major depressive disorder
Huda depresija
You should immediately have an eye examination before the treatment with this medicine can be continued.
Pred nadaljevanjem zdravljenja s tem zdravilom vam morajo takoj opraviti pregled oči, ker so to lahko znaki akutnega glavkoma.
• Major Depressive Disorder
• huda depresija
Effects on the blood could be a decrease in the number of red cells (which carry oxygen around the body), white cells (which help to fight infection) and platelets (which help with clotting).
• modrice, krvavitev, bledica ali persistentno vneto žrelo in zvišana telesna temperatura Ti simptomi so lahko prvi znak krvne bolezni ali prizadetosti kostnega mozga, kot so lahko zmanjšanje števila rdečih krvnih celic (ki po telesu prenašajo kisik), belih krvnih celic (ki pomagajo v boju proti okužbam) in krvnih ploščic (ki pomagajo pri strjevanju krvi).
<[Saroten and associated names 10 mg film-coated tablets; Saroten and associated names 25 mg filmcoated tablets; Saroten and associated names 25 mg prolonged-release capsules, hard; Saroten and associated names 50 mg prolonged-release capsules, hard; Saroten and associated names 50 mg filmcoated tablets]
<[Saroten in povezana imena 10 mg filmsko obložene tablete; Saroten in povezana imena 25 mg filmsko obložene tablete; Saroten in povezana imena 25 mg trde kapsule s podaljšanim sproščanjem;
• thyroid disease
• hudo bolezen jeter
• drowsiness
• omotičnost
<[Saroten and associated names 75 mg, modified release tablets] The score line facilitates breaking of the retard tablet into 3 equal doses.
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem] Razdelilna zareza olajša lomljenje tablete s prirejenim sproščanjem na 3 enake dele.
Initially 50 mg daily in the evening.
Začetni odmerek je 50 mg na dan zvečer.
The active substance is amitriptyline.
Učinkovina je amitriptilinijev klorid.
• congested nose.
• agresivnost • zamašen nos
Very common Orthostatic hypotension.
Žilne bolezni zelo pogosti ortostatska hipotenzija občasni hipertenzija neznana pogostnost hipertermija
Further treatment with oral formulation:
Nadaljevanje zdravljenja s peroralno obliko
Allergic inflammation of the pulmonary alveoli and of the lung tissue, respectively (alveolitis, Löffler's syndrome).
Bolezni dihal, prsnega koša in mediastinalnega prostora zelo pogosti zamašen nos zelo redki alergijsko vnetje pljučnih alveolov ali pljučnega tkiva (alveolitis, Loefflerjev sindrom)
What you need to know before you are given X
Kaj morate vedeti, preden vam bodo dali zdravilo X Zdravila X ne boste prejeli:
Weight decreased.
Zmanjšano delovanje jeter
Patency of the airway is maintained by intubation, where required.
Če je potrebno, je treba vzdrževati prehodnost dihal z intubacijo.
The recommended dose is:
Priporočeni odmerki za otroke:
• tinnitus
• navzea
Sympathomimetic agents: Amitriptyline may potentiate the cardiovascular effects of adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, and phenylpropanolamine (e.g. as contained in local and general anaesthetics and nasal decongestants).
izoprenalina, noradrenalina, fenilefrina in fenilpropanolamina (npr. vsebovanih v lokalnih in splošnih anestetikih in nosnih dekongestivih).
• Chronic tension type headache prophylaxis
• preprečevanje kroničnega glavobola tenzijskega tipa
Rare (> 1/10,000, < 1/1,000);
Redki (≥ 1/10.000, < 1/1.000);
• decreased heart rate
• poslabšanje srčnega popuščanja
• Depression in adults (major depressive episodes)
To zdravilo se uporablja za zdravljenje: • depresije pri odraslih (hude depresivne epizode)
Recommended doses are 25 mg - 75 mg in the evening.
Priporočeni odmerki so 25 mg - 75 mg zvečer.
Anticholinergic symptoms: Mydriasis, tachycardia, urinary retention, dry mucous membranes, reduced bowel motility.
Antiholinergični simptomi: midriaza, tahikardija, zastajanje urina, suhe sluznice, upočasnjeno gibanje črevesja, konvulzije, zvišana telesna temperatura, nenadni pojav depresije osrednjega živčevja,