natgillin/translations-raw huggingface dataset:
Following intravenous administration, the elimination phase half-life averaged 15.1 hours.
Po intravenski uporabi je bil razpolovni čas izločanja v povprečju 15,1 ure.
This is important as Avamys is a thick suspension that becomes liquid when you shake it well - see picture b. It will only spray when it becomes liquid.
To je pomembno, kajti zdravilo Avamys je gosta suspenzija, ki postane tekoča, ko jo dobro pretresete - glejte sliko b. Upršiti jo je mogoče šele, ko postane tekoča.
This small increase in exposure did not result in a statistically significant difference in 24 hour serum cortisol levels between the two groups.
To manjše povečanje izpostavljenosti ni imelo za posledico statistično pomembne razlike v 24-urnih vrednostih kortizola v serumu med obema skupinama .
Be careful not to get any spray into your eyes.
Pazite, da vam pršilo ne pride v oči.
Patients on ritonavir
Bolniki, ki prejemajo ritonavir
The following convention has been used for the classification of frequencies: Very common ≥1/10; Common ≥1/100 to <1/10; Uncommon ≥1/1000 to <1/100; Rare ≥1/10,000 to <1/1000; Very rare
Pri razvrstitvi pogostnosti je upoštevan naslednji dogovor: zelo pogosti ≥ 1/10, pogosti ≥ 1/100 in < 1/10, občasni ≥ 1/1.000 in < 1/100, redki ≥ 1/10.000 in < 1/1.000 ter zelo redki < 1/10.000.
6 Take the nozzle out and breathe out through your mouth.
6 Vzemite nastavek ven in izdihnite skozi usta.
Preparing the nasal spray helps to make sure you always get the full dose of medicine.
Priprava pršila za nos pomaga zagotoviti, da vedno dobite poln odmerek zdravila.
It is sprayed into the nose as a fine mist.
V nos se vprši kot drobna meglica.
Allergic reactions to Avamys are rare and affect less than 1 person in 1,000.
Alergijske reakcije na zdravilo Avamys so redke in se pojavijo pri manj kot 1 od 1.000 oseb.
The duration of treatment should be restricted to the period that corresponds to allergenic exposure.
Zdravljenje mora biti omejeno na obdobje izpostavljenosti alergenu.
You will then be able to see the level through the window.
Tako boste skozi okence lahko videli raven.
You will be able to see the liquid level for a new 30 or 60 spray bottle, but not in a new 120 spray bottle because the liquid level is above the window.
Raven tekočine boste lahko videli v novi steklenički s 30 ali 60 vpihi, ne pa v novi steklenički s 120 vpihi, ker je tekočina v njej nad ravnjo okenca.
You may also get streaks of blood when you blow your nose.
Pojavijo se lahko tudi sledovi krvi, ko pihnete skozi nos;
• If you have difficulty pressing the button with your thumb, you can use two hands - see picture d
• Če gumb težko pritisnete s palcem, lahko uporabite obe roki - glejte sliko d.
• before you use it for the first time • if you have left the cap off for 5 days or the intranasal device has not been used for 30 days or more.
• preden ga prvič uporabite, • če pokrovček ni bil nameščen 5 dni ali nosnega pripomočka niste uporabljali 30 dni ali več.
This will treat your symptoms throughout the day and night.
Pri takšni uporabi bo zdravilo učinkovalo na simptome podnevi in ponoči.
The window in the plastic casing lets you see how much Avamys is left in the bottle.
Skozi okence v plastičnem ohišju lahko vidite, koliko zdravila Avamys je še v steklenički.
The plasma protein binding of fluticasone furoate is greater than 99 %.
Vezava flutikazonfuroata na plazemske proteine je večja od 99 %.
Avamys nasal spray should be used within 2 months after first opening.
Avamys pršilo za nos morate porabiti v 2 mesecih po prvem odprtju.
These effects are much less likely to occur than with oral corticosteroids and may vary in individual patients and between different corticosteroid preparations.
Ti učinki so veliko manj verjetni kot pri peroralnih kortikosteroidih ter se lahko razlikujejo od bolnika do bolnika in med različnimi pripravki kortikosteroidov.
• Slowing of growth in children.
• upočasnjena rast pri otrocih,
30 sprays 60 sprays 120 sprays
30 vpihov 60 vpihov 120 vpihov
The mean treatment difference was -0.27 cm per year [95% CI -0.48 to -0.06].
Povprečna razlika med skupinama je bila -0,27 cm na leto [95 % IZ -0,48 do -0,06].
In a small number of people, allergic reactions can develop into a more serious, even life-threatening problem if not treated.
Če alergijske reakcije niso zdravljene, se lahko pri majhnem številu oseb razvijejo v resnejšo, celo smrtno nevarno težavo.
Avamys should not be used at the same time with other nasal sprays containing steroids.
Zdravila Avamys se ne sme uporabljati hkrati z drugimi pršili za nos, ki vsebujejo steroide.
If it is nearly the time for your next dose, wait until then.
Če je že skoraj čas, da uporabite naslednji predvideni odmerek, počakajte in uporabite naslednji odmerek ob običajnem času.
Do not use this medicine after the expiry date which is stated on the label and carton.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki ali škatli poleg oznake »EXP«.
Tell your doctor or pharmacist if you are taking, or have recently taken, or might take any other medicines, including medicines obtained without a prescription.
Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katerokoli zdravilo; to velja tudi za zdravila, ki ste jih dobili brez recepta.
The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch
Natisnjeno navodilo za uporabo tega zdravila mora vključevati navedbo imena in naslova izdelovalca, odgovornega za sproščanje zadevne serije.
Repriming (approximately 6 sprays until a fine mist is seen) is only necessary if the cap is left off for 5 days or the intranasal device has not been used for 30 days or more.
Ponovna aktivacija (približno 6 pršenj, dokler se ne pojavi fina meglica) je potrebna le, če pokrovček ni bil nameščen 5 dni, ali če se pršilnik ni uporabljal 30 dni ali več.
Avamys (fluticasone furoate) belongs to a group of medicines called glucocorticoids.
Zdravilo Avamys (flutikazonfuroat) spada v skupino zdravil, imenovanih glukokortikoidi.
3 Blow your nose to clear your nostrils, then tilt your head forward a little bit.
Pihnite skozi nos, da si boste očistili nosnici, nato glavo nagnite nekoliko naprej.
If you forget to use Avamys If you miss a dose, take it when you remember.
Če ste pozabili uporabiti odmerek, ga uporabite, ko se spomnite.
If you are pregnant or breast-feeding, think you may be pregnant or a planning to have a baby, ask your doctor for advice before taking this medicine.
Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom, preden vzamete to zdravilo.
Tell your doctor if you had these conditions in the past, or if you notice blurred vision or other visual disturbances while you are taking Avamys.
Povejte vašemu zdravniku, če ste kdaj v preteklosti imeli te motnje ali če med uporabo zdravila Avamys opazite zamegljen vid ali druge motnje vida.
The most serious undesirable effects are rare reports of hypersensitivity reactions, including anaphylaxis (less than 1 case per 1000 patients).
Najresnejši neželeni učinki so redko poročani primeri preobčutljivostnih reakcij, vključno z anafilaksijo (manj kot 1 primer na 1000 bolnikov).
Avamys works to decrease inflammation caused by allergy (rhinitis) and therefore reduce symptoms of allergy.
Zdravilo Avamys deluje tako, da zmanjša vnetje, ki ga povzroči alergija (rinitis), in tako zmanjša simptome alergije.
For full therapeutic benefit regular, scheduled usage is recommended.
Da dosežemo popolno terapevtsko korist, je priporočljivo zdravilo uporabljati redno.
The doctor will check your child's height regularly, and make sure he or she is taking the lowest possible effective dose.
Zdravnik bo redno nadziral otrokovo telesno višino in otroku predpisal najmanjši še učinkoviti odmerek;
What Avamys is and what it is used for
Kaj je zdravilo Avamys in za kaj ga uporabljamo
Do not use Avamys:
Ne uporabljajte zdravila Avamys:
If the level is very low there may not be enough left to work the nasal spray.
Če je raven zelo nizka, morda zdravila ni več dovolj, da bi pršilo za nos delovalo.
The safety and efficacy of Avamys in children under the age of 6 years has not been established.
Varnost in učinkovitost zdravila Avamys pri otrocih, mlajših od 6 let, nista ugotovljeni.
The primary outcomes [time to increase in posterior subcapsular opacity (0.3 from baseline in Lens Opacities Classification System, Version III (LOCS III grade)) and time to increase in intraocular pressure (IOP; 7 mmHg from baseline)] were not statistically significant between the two groups.
Primarna izida [čas do povečanja posteriorne subkapsularne motnosti ( 0,3 od izhodišča po sistemu LOCS (Lens Opacities Classification System, različica III; LOCS III. stopnje)) in čas do zvišanja očesnega tlaka ( 7 mmHg od izhodišča)] se med obema skupinama nista statistično značilno razlikovala.
But you must be aware that they are potentially serious - so, if you notice any of these symptoms:
Vendar se morate zavedati, da so lahko resni, zato v primeru, da opazite katerega od njih: pojdite čim prej k zdravniku.
In adults and adolescents, the incidence of epistaxis was higher in longer-term use (more than 6 weeks) than in short-term use (up to 6 weeks).
Pri odraslih in mladostnikih je bila krvavitev iz nosu pogostejša pri dolgotrajnejši uporabi (daljši od 6 tednov) kot pri krajši uporabi (do 6 tednov).
Nasal spray, suspension 1 bottle - 30 sprays 1 bottle - 60 sprays 1 bottle - 120 sprays
pršilo za nos, suspenzija 1 steklenica - 30 vpihov 1 steklenica - 60 vpihov 1 steklenica - 120 vpihov
Glaxo Operations UK Ltd (trading as Glaxo Wellcome Operations) Harmire Road
Glaxo Operations UK Ltd (pod imenom Glaxo Wellcome Operations) Harmire Road
• If symptoms are very bad your doctor may increase the dose to 2 sprays in each nostril once every day until the symptoms are under control.
• Če so simptomi zelo hudi, lahko zdravnik odmerek poveča na 2 vpiha v vsako nosnico enkrat na dan, dokler simptomi niso pod nadzorom.
Other medicines and Avamys
Druga zdravila in zdravilo Avamys
Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu
Podrobne informacije o tem zdravilu so objavljene na spletni strani Evropske agencije za zdravila: http://www.ema.europa.eu.
7 If your dose is 2 sprays in each nostril repeat steps 4 to 6.
7 Če je vaš odmerek 2 vpiha v vsako nosnico, ponovite korake od 4 do 6. 8 Ponovite korake od 4 do 7 za zdravljenje na drugi nosnici.
• medicines for asthma
• zdravila za zdravljenje astme,
Your doctor will assess whether you should take Avamys with these medicines.
Zdravnik bo presodil, če smete zdravilo Avamys uporabljati skupaj s temi zdravili.
Children under 6 years of age
Otroci, mlajši od 6 let
Less than 1 % of dose-related material is excreted in urine and therefore renal impairment would not be expected to affect the pharmacokinetics of fluticasone furoate.
Z urinom se izloči manj kot 1 % vnesenega odmerka, zato v primeru okvare ledvic vpliva na farmakokinetiko flutikazonfuroata ne pričakujemo.
The nasal spray is now ready for use.
Pršilo za nos je sedaj pripravljeno za uporabo.
Onset of therapeutic benefit was observed as early as 8 hours after initial administration, with further improvement observed for several days afterwards.
Pojav terapevtske koristi so opazili že 8 ur po začetku uporabe, po nekaj dneh zdravljenja pa so poročali še o nadaljnjem izboljšanju.
Avamys is indicated in adults, adolescents and children (6 years and over)
Zdravilo Avamys je indicirano pri odraslih, mladostnikih in otrocih (starih 6 let ali več).
Fluticasone furoate should be used in pregnancy only if the benefits to the mother outweigh the potential risks to the foetus or child.
Flutikazonfuroat se sme med nosečnostjo uporabljati le, če koristi za mater prevladajo nad kakršnimkoli tveganjem za plod ali otroka.
Therefore, children should be maintained on the lowest possible efficacious dose which delivers adequate symptom control (see section 4.2).
Zato je treba za vzdrževalno zdravljenje otrok uporabljati najmanjši možni učinkoviti odmerek, ki zagotovi ustrezno obvladovanje simptomov (glejte poglavje 4.2).
Fluticasone furoate is a synthetic trifluorinated corticosteroid that possesses a very high affinity for the glucocorticoid receptor and has a potent anti-inflammatory action.
Flutikazonfuroat je sintetični trifluorirani kortikosteroid z zelo veliko afiniteto za glukokortikoidne receptorje in močnim protivnetnim delovanjem.
Coadministration should be avoided unless the benefit outweighs the increased risk of systemic corticosteroid side effects, in which case patients should be monitored for systemic corticosteroid side effects.
Sočasni uporabi se je treba izogniti, razen če korist odtehta povečano tveganje za pojav sistemskih neželenih učinkov kortikosteroidov; v tem primeru je treba bolnike nadzorovati glede sistemskih neželenih učinkov kortikosteroidov.
1 Wipe the nozzle and inside of the cap with a clean, dry tissue - see pictures i and j.
1 Obrišite nastavek in notranjost pokrovčka s čisto, suho krpico - glejte sliki i in j.
There was no evidence for a higher incidence of patients with quantifiable fluticasone furoate concentrations in the elderly, when compared with the younger patients.
Ni dokazov o večji pojavnosti merljivih koncentracij flutikazonfuroata pri starejših bolnikih v primerjavi z mlajšimi bolniki.
Adults and adolescents (12 years and over)
Odrasli in mladostniki (stari 12 let in starejši)
Your doctor may wish to monitor you carefully if you are taking any of these medicines as they may increase the side effects of Avamys.
Če jemljete katero od teh zdravil, vas bo zdravnik morda skrbno spremljal, kajti ta zdravila lahko povečajo neželene učinke zdravila Avamys.
• Nasal ulceration - which may cause irritation or discomfort in your nose.
• razjeda v nosu - ki lahko povzroči draženje in neprijeten občutek v nosu.
• may cause eye conditions such as glaucoma (increase in pressure in the eye) or cataracts (clouding of the lens of the eye).
• lahko povzroči spremembe na očeh, npr. glavkom (zvišan očesni tlak) ali katarakto (zamotnitev očesne leče).
Look at the level through the window.
Raven preverite skozi okence.
Findings in general toxicology studies were similar to those observed with other glucocorticoids and are associated with exaggerated pharmacological activity.
Ugotovitve študij splošne toksičnosti so podobne ugotovitvam pri študijah z drugimi glukokortikoidi in se nanašajo na poudarjeno farmakološko delovanje.
In a bioavailability study, intranasal doses of up to 2640 micrograms per day were administered over three days with no adverse systemic reactions observed (see section 5.2).
V študiji biološke uporabnosti so tri dni uporabljali nazalne odmerke do 2.640 mikrogramov na dan, pri čemer neželenih sistemskih reakcij niso opazili (glejte poglavje 5.2).
The nasal spray comes in an amber glass bottle inside a plastic casing - see picture a. It will contain either 30, 60 or 120 sprays, depending on the pack size that has been prescribed for you.
Pršilo za nos je na voljo v steklenički jantarne barve v plastičnem ohišju - glejte sliko a. Vsebuje količino zdravila za 30, 60 ali 120 vpihov, odvisno od velikosti pakiranja, ki vam ga je predpisal zdravnik.
Avamys is available in pack sizes 30, 60 and 120 sprays.
Zdravilo Avamys je na voljo v pakiranjih za 30, 60 in 120 vpihov.
If there is any reason to believe that adrenal function is impaired, care must be taken when transferring patients from systemic steroid treatment to fluticasone furoate.
Če obstaja kakšen razlog za domnevo o okvarjenem delovanju nadledvičnih žlez, je pri prehodu bolnikov s sistemskega steroidnega zdravljenja na flutikazonfuroat potrebna previdnost.
4 Place the nozzle in one of your nostrils - see picture g. Point the end of the nozzle slightly outwards, away from the centre ridge of your nose.
Dajte nastavek v eno od nosnic - glejte sliko g. Usmerite konec nastavka rahlo navzven, proč od nosnega pretina.
If you need to check how much is left hold the nasal spray upright against a bright light.
Če želite preveriti, koliko zdravila je še ostalo, držite pršilo za nos obrnjeno pokonci proti močni svetlobi.
The casing has a window for viewing the bottle contents.
Na ohišju je okence, ki omogoča vpogled v vsebino stekleničke.
Children (6 to 11 years of age)
Otroci (stari od 6 do 11 let)
In children this side effect can cause them to grow more slowly than others.
Pri otrocih lahko ta neželeni učinek povzroči počasnejšo rast.
• If it is still not working, or if it produces a jet of liquid, take the nasal spray back to the pharmacy to get advice.
• Če še vedno ne deluje ali če brizgne tekočino, nesite pršilo v lekarno, kjer vam bodo svetovali.
Fluticasone furoate is rapidly cleared (total plasma clearance of 58.7 l/h) from systemic circulation principally by hepatic metabolism to an inactive 17β-carboxylic metabolite (GW694301X), by the cytochrome P450 enzyme CYP3A4.
Flutikazonfuroat se hitro očisti iz sistemske cirkulacije (skupni plazemski očistek 58,7 l/h), predvsem s presnovo v jetrih do neaktivnega 17-karboksilnega presnovka (GW694301X) z encimom CYP3A4 citokroma P450.
If the nasal spray does not seem to be working:
Če pršilo za nos noče delovati:
Paediatric exposure to fluticasone furoate in safety and efficacy studies in seasonal and perennial allergic rhinitis included 243 patients 12 to <18 years, 790 patients 6 to <12 years and 241 patients 2 to <6 years.
Izpostavljenost pediatričnih bolnikov flutikazonfuroatu v študijah varnosti in učinkovitosti pri sezonskem in celoletnem alergijskem rinitisu je vključevala 243 bolnikov, starih od 12 do < 18 let, 790 bolnikov, starih od 6 do < 12 let, in 241 bolnikov, starih od 2 do < 6 let.
What Avamys is and what it is used for What you need to know before you use Avamys How to use Avamys
Kaj je zdravilo Avamys in za kaj ga uporabljamo Kaj morate vedeti, preden boste uporabili zdravilo Avamys Kako uporabljati zdravilo Avamys Možni neželeni učinki
Fertility There are no fertility data in humans.
Plodnost Podatkov o plodnosti pri človeku ni.
The medicinal product is available in three pack sizes: 1 bottle of 30, 60 or 120 sprays.
Zdravilo je na voljo v treh pakiranjih: 1 steklenička s 30, 60 ali 120 vpihi.
There are no adequate data from the use of fluticasone furoate in pregnant women.
Podatki o uporabi flutikazonfuroata med nosečnostjo niso zadostni.
What you need to know before you use Avamys
Kaj morate vedeti, preden boste uporabili zdravilo Avamys
Nasal corticosteroids can affect the normal production of hormones in your body, particularly if you use high doses for a long time.
Nazalni kortikosteroidi lahko vplivajo na normalno nastajanje hormonov v vašem telesu, predvsem ob dolgotrajnem jemanju visokih odmerkov.
Potential systemic effects may include Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in children and adolescents, cataract, glaucoma and more rarely, a range of psychological or behavioural effects including psychomotor hyperactivity, sleep disorders, anxiety, depression or aggression (particularly in children).
Med možnimi sistemskimi učinki so lahko Cushingov sindrom, Cushingoidne značilnosti, zavora delovanja nadledvičnih žlez, upočasnitev rasti pri otrocih in mladostnikih, katarakta, glavkom in, redkeje, vrsta psiholoških ali vedenjskih učinkov, med njimi psihomotorična hiperaktivnost, motnje spanja, anksioznost, depresija ali napadalnost (zlasti pri otrocih).
• When you first use the nasal spray you will need to shake it vigorously with the cap on for about 10 seconds.
• Ko uporabite pršilo za nos prvič, ga morate (z nameščenim pokrovčkom) približno 10 sekund močno stresati.
In animal studies glucocorticoids have been shown to induce malformations including cleft palate and intra-uterine growth retardation.
Študije na živalih so pokazale, da glukokortikoidi povzročajo malformacije, vključno z razcepljenim nebom, in zaostajanje razvoja v maternici.
• The mist-release button must be pressed firmly all the way in, to release the mist through the nozzle - see picture c.
• Gumb za sprostitev meglice morate pritisniti močno povsem do konca noter, da se skozi nastavek sprosti meglica - glejte sliko c.
Avamys is indicated for the treatment of the symptoms of allergic rhinitis.
Zdravilo Avamys je indicirano za zdravljenje simptomov alergijskega rinitisa.
Avamys contains benzalkonium chloride
Zdravilo Avamys vsebuje benzalkonijev klorid.
The safety in children under 6 years has not been well established.
Varnost pri otrocih, mlajših od 6 let, še ni bila dokazana.
In some patients benzalkonium chloride can cause irritation in the inside of the nose.
Benzalkonijev klorid lahko pri nekaterih bolnikih povzroči draženje nosne sluznice.
These events were transient in nature for six subjects in the fluticasone furoate group and one placebo subject.
Ti dogodki so bili prehodni pri šestih preiskovancih v skupini s flutikazonfuroatom in pri enem preiskovancu v skupini s placebom.
5 Press the button firmly all the way in, while you breathe in through your nose - see picture h.
Močno pritisnite gumb povsem do konca, medtem ko vdihnete skozi nos - glejte sliko h.
Only a small number of elderly patients (≥ 65 years, n=23/872; 2.6 %) provided pharmacokinetic data.
Farmakokinetični podatki so bili pridobljeni le pri manjšem številu starejših bolnikov ( 65 let, n = 23/872; 2,6 %).
Acute overdose is unlikely to require any therapy other than observation.
Verjetnost, da bi bilo v primeru akutnega prevelikega odmerjanja potrebno kakršnokoli zdravljenje, razen opazovanja, je majhna.
Epistaxis *In paediatric clinical studies of up to 12 weeks duration the incidence of epistaxis was similar between patients receiving fluticasone furoate and patients receiving placebo.
Krvavitev iz nosu *V kliničnih študijah pri otrocih, ki so trajale do 12 tednov, je bila pojavnost krvavitev iz nosu podobna pri bolnikih, ki so prejemali flutikazonfuroat, in bolnikih, ki so prejemali placebo.
If you use more Avamys than you should Talk to your doctor or pharmacist.
Če ste uporabili večji odmerek zdravila Avamys, kot bi smeli Posvetujte se s svojim zdravnikom ali farmacevtom.
The absolute bioavailability for intranasal fluticasone furoate is 0.50 %, such that less than 1 microgram of fluticasone furoate would be systemically available after administration of 110 micrograms (see section 4.9).
Absolutna biološka uporabnost nazalnega flutikazonfuroata je 0,50-odstotna, tako, da je pri uporabi 110 mikrogramskega odmerka sistemsko razpoložljivega manj kot 1 mikrogram flutikazonfuroata (glejte poglavje 4.9).
Fluticasone furoate nasal spray significantly improved the patients' perception of overall response to therapy, and the patients' disease-related quality of life (Rhinoconjunctivitis Quality of Life Questionnaire - RQLQ), in all 4 studies.
Flutikazonfuroat v obliki pršila za nos je v vseh 4 študijah pomembno izboljšal bolnikov vtis o celotnem odzivu na zdravljenje in z boleznijo povezano kakovost življenja bolnika (vprašalnik o kakovosti življenja z rinokonjunktivitisom; “Rhinoconjunctivitis Quality of Life Questionnaire”RQLQ).
Symptoms include: - becoming very wheezy, coughing or having difficulty with breathing - suddenly feeling weak or light-headed (which may lead to collapse or loss of consciousness) - swelling around the face - skin rashes or redness.
Med simptomi so: - zelo piskajoče dihanje, kašelj ali težko dihanje, - nenaden občutek slabosti ali vrtoglavosti (to lahko povzroči kolaps ali izgubo zavesti), - oteklost obraza, - izpuščaj ali pordelost kože.
Based on data with another glucocorticoid (fluticasone propionate), that is metabolised by CYP3A4, coadministration with ritonavir is not recommended because of the risk of increased systemic exposure of fluticasone furoate.
Na osnovi podatkov, pridobljenih z drugim kortikosteroidom (flutikazonpropionatom), ki se presnavlja s CYP3A4, sočasne uporabe ritonavirja ne priporočamo zaradi tveganja za večjo sistemsko izpostavljenost flutikazonfuroatu.