natgillin/translations-raw huggingface dataset:
One-day-old ducklings were given a single injection of Parvoduk and then exposed two weeks later to either Muscovy duck parvovirus or goose parvovirus.
En dan stare mladiče so cepili z eno injekcijo zdravila Parvoduk in jih dva tedna kasneje izpostavili bodisi parvovirusu rac moškatnih bleščavk ali parvovirusu gosi.
In the future, if the animals are exposed to Muscovy duck parvovirus, the immune system will be able to respond more quickly.
Ob morebitni ponovni izpostavitvi parvovirusu rac moškatnih bleščavk se bo imunski sistem lahko odzval hitreje.
When Parvoduk is given to Muscovy ducks the animals' immune system recognises the viruses as ‘foreign' and makes antibodies against them.
Ko race moškatne bleščavke cepimo z zdravilom Parvoduk, njihov imunski sistem viruse prepozna kot „tujke“ in proti njim razvije protitelesa.
Two further studies were carried out to investigate the effects of Parvoduk in ducklings who had inherited protective antibodies against Muscovy duck parvovirus or goose parvovirus from their mother.
Dve nadaljnji študiji sta bili opravljeni, da bi preiskali učinke zdravila Parvoduk pri mladičih, ki so po materi podedovali zaščitna protitelesa proti parvovirusu rac moškatnih bleščavk ali parvovirusu gosi.
Parvoduk is a veterinary vaccine that contains live attenuated (weakened) Muscovy duck parvovirus.
Zdravilo Parvoduk je veterinarsko cepivo, ki vsebuje živ atenuiran (oslabljen) parvovirus rac moškatnih bleščavk.
This will help protect them against Muscovy duck parvovirosis.
To bo pripomoglo k zaščiti rac pred parvovirozo rac moškatnih bleščavk.
How has Parvoduk been studied?
Kako je bilo zdravilo Parvoduk raziskano?
Muscovy duck parvovirus (live attenuated)
Parvovirus rac moškatnih bleščavk (živ, atenuiran)
Parvoduk is used to protect Muscovy ducks against Muscovy duck parvovirosis and Derzsy's disease.
Zdravilo Parvoduk se uporablja za zaščito rac moškatnih bleščavk pred parvovirozo rac moškatnih bleščavk in Derzsyjevo boleznijo.
How does Parvoduk work?
Kako zdravilo Parvoduk deluje?
The further study showed that Parvoduk vaccination of ducklings was not counteracted by protective antibodies from their mother.
Nadaljnja študija je pokazala, da zaščitna protitelesa, podedovana po materi, niso imela negativnega učinka na cepljenje mladičev z zdravilom Parvoduk.
Muscovy duck parvovirosis is an infectious disease caused by Muscovy duck parvovirus.
Parvoviroza rac moškatnih bleščavk je nalezljiva bolezen, ki jo povzroča parvovirus rac moškatnih bleščavk.
What is Parvoduk?
Kaj je zdravilo Parvoduk?
The withdrawal period for Parvoduk is zero days.
Karenca za zdravilo Parvoduk je nič dni.
What is the withdrawal period?
Kako dolgo traja obdobje karence?
MA (EU) number (Invented) name Strength Pharmaceutical Form
(Izmišljeno) ime Jakost Farmacevtska oblika
This summary was last updated in 01/2018.
Povzetek je bil nazadnje posodobljen 01/2018.
The recommended dose is one tablet a day, taken with food.
Priporočeni odmerek je ena tableta na dan, ki se vzame s hrano.
The European Commission granted a marketing authorisation valid throughout the European Union for Genvoya on 19 November 2015.
Evropska komisija je dovoljenje za promet z zdravilom Genvoya, veljavno po vsej Evropski uniji, izdala 19. novembra 2015.
The CHMP also considered that combining the medicines in a single tablet simplifies treatment.
Odbor CHMP je prav tako menil, da združitev zdravil v eni tableti poenostavlja zdravljenje.
What measures are being taken to ensure the safe and effective use of Genvoya?
Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Genvoya?
This is a summary of the European public assessment report (EPAR) for Genvoya.
To je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Genvoya.
The Agency's Committee for Medicinal Products for Human Use (CHMP) decided that Genvoya's benefits are greater than its risks and recommended that it be approved for use in the EU.
Odbor za zdravila za uporabo v humani medicini (CHMP) je zaključil, da so koristi zdravila Genvoya večje od z njim povezanih tveganj, in priporočil, da se odobri za uporabo v EU.
Other information about Genvoya
Druge informacije o zdravilu Genvoya
The full EPAR for Genvoya can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Genvoya je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Genvoya must not be taken with certain other medicines because of the possibility of harmful interactions.
Zdravilo Genvoya se ne sme jemati z nekaterimi drugimi zdravili zaradi možnosti škodljivih interakcij.
This reduces the virus's ability to replicate and slows down the spread of infection.
To zmanjšuje sposobnost virusa, da se razmnožuje, in upočasni širjenje okužbe.
It is used in adults and adolescents aged over 12 years whose disease is not expected to be resistant to any of the antiviral substances in Genvoya.
Uporablja se pri odraslih in mladostnikih, starejših od 12 let, pri katerih ni pričakovati, da bo njihova bolezen odporna proti kateri koli od protivirusnih učinkovin v zdravilu Genvoya.
Other side effects include abnormal dreams, dizziness, feeling tired, and diarrhoea.
Drugi neželeni učinki vključujejo nenavadne sanje, omotičnost, utrujenost in drisko.
In a supporting study, patients who were being treated with effective HIV treatment either continued with the same treatment or were switched to Genvoya.
V podporni študiji so bolniki, ki so bili deležni učinkovitega zdravljenja okužbe z virusom HIV, bodisi nadaljevali z enakim zdravljenjem ali pa so prešli na zdravilo Genvoya.
The main measure of effectiveness was based on the reduction of the amount of HIV-1 in the blood.
Glavno merilo učinkovitosti je bilo zmanjšanje količine virusa HIV-1 v krvi.
Further data indicated that Genvoya can be used safely in children as young as 6 years of age.
Nadaljnji podatki so pokazali, da je zdravilo Genvoya varno za uporabo tudi pri mlajših otrocih, starih šest let.
After 48 weeks around 90% of patients treated with both Genvoya (800 of 866 patients) and the comparator (784 of 867 patients) had responded to treatment.
Po 48 tednih se je okoli 90 % bolnikov, zdravljenih tako z zdravilom Genvoya (800 od 866 bolnikov) kot s primerjalnim zdravilom (784 od 867 bolnikov), odzvalo na zdravljenje.
The infection was considered to have responded to treatment if the viral load in the patient's blood was less than 50 of HIV-1 RNA copies/ml.
Za okužbo je veljalo, da se je odzvala na zdravljenje, če je bila virusna obremenitev v bolnikovi krvi manjša od 50 HIV-1 RNK kopij/ml.
Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Genvoya have been included in the summary of product characteristics and the package leaflet.
Priporočila in varnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Genvoya upoštevati zdravstveni delavci in bolniki, so vključeni v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo.
The most common side effect with Genvoya (which may affect more than 1 in 10 people) is nausea (feeling sick).
Najpogostejši neželeni učinek zdravila Genvoya (ki lahko prizadene več kot 1 osebo od 10) je navzeja (slabost).
Genvoya is available as tablets, each containing 150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine and 10 mg tenofovir alafenamide.
Zdravilo Genvoya je na voljo v obliki tablet, od katerih vsaka vsebuje 150 mg elvitegravirja, 150 mg kobicistata, 200 mg emtricitabina in 10 mg alafenamidtenofovirata.
Genvoya's side effects were similar to those of the individual medicines.
Neželeni učinki zdravila Genvoya so bili podobni tistim, ki so značilni za posamezna zdravila.
For more information about treatment with Genvoya, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Za več informacij o zdravljenju z zdravilom Genvoya preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
By blocking an enzyme called integrase, elvitegravir stops the virus's genetic material from integrating into the genetic material of the cells it has infected.
Z zaviranjem encima, imenovanega integraza, elvitegravir prepreči vključitev genskega materiala virusa v genski material celic, ki jih je okužil.
This boosts elvitegravir's antiviral effect.
To okrepi protivirusni učinek elvitegravirja.
Genvoya elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide
Genvoya elvitegravir/kobicistat/emtricitabin/alafenamidtenofovirat
Genvoya is an antiviral medicine used to treat individuals infected with human immunodeficiency virus type 1 (HIV-1), a virus that causes acquired immune deficiency syndrome (AIDS).
Zdravilo Genvoya je protivirusno zdravilo za zdravljenje posameznikov, ki so okuženi z virusom humane imunske pomanjkljivosti tipa 1 (HIV-1), tj. virusom, ki povzroča sindrom pridobljene imunske pomanjkljivosti (aids).
What are the risks associated with Genvoya?
Kakšna tveganja so povezana z zdravilom Genvoya?
Genvoya was investigated in two main studies involving 1,733 adults infected with HIV-1 who had not been treated previously.
Zdravilo Genvoya so proučevali v dveh glavnih študijah s 1 733 odraslimi, okuženimi z virusom HIV-1, ki predhodno še niso bili zdravljeni.
What is Genvoya and what is it used for?
Kaj je zdravilo Genvoya in za kaj se uporablja?
Genvoya contains four active substances.
Zdravilo Genvoya vsebuje štiri zdravilne učinkovine.
What benefits of Genvoya have been shown in studies?
Kakšne koristi je zdravilo Genvoya izkazalo v študijah?
This study also involved 23 children aged 8 to 11 years weighing at least 25 kg, and showed that after 48 weeks of treatment with Genvoya the viral load was reduced to less than 50 copies/ml in all patients.
V tej študiji je sodelovalo tudi 23 otrok, starih od 8 do 11 let, s telesno maso najmanj 25 kg, pri čemer se je pri vseh bolnikih po 48 tednih zdravljenja z zdravilom Genvoya virusna obremenitev zmanjšala na manj kot 50 kopij/ml.
The fourth, tenofovir alafenamide, is effective at a lower dose than the established medicine tenofovir disoproxil and offers the possibility of reduced side effects.
Četrta, alafenamidtenofovirat, je učinkovita pri nižjih odmerkih od uveljavljenega zdravila dizoproksiltenofovirat in ponuja možnost zmanjšanja neželenih učinkov.
The viral load was reduced to less than 50 copies/ml after 24 weeks in 90% (45 of 50) of patients.
Njihova virusna obremenitev je bila po 24 tednih zmanjšana na manj kot 50 kopij/ml pri 90 % (45 od 50) bolnikov.
Genvoya does not cure HIV-1 infection or AIDS, but it may delay the damage to the immune system and the development of infections and diseases associated with AIDS.
Zdravilo ne zdravi okužbe z virusom HIV-1 ali aidsa, lahko pa upočasni slabšanje imunskega sistema ter razvoj okužb in bolezni, povezanih z aidsom.
They block the activity of reverse transcriptase, a virus enzyme that allows HIV-1 to replicate in the cells it has infected.
Ti zavirajo delovanje reverzne transkriptaze, tj. virusnega encima, ki omogoča, da se HIV-1 razmnožuje v celicah, ki jih je okužil.
By blocking reverse transcriptase, Genvoya reduces the amount of HIV-1 in the blood and keeps it at a low level.
Zdravilo Genvoya z zaviranjem reverzne transkriptaze zniža količino virusa HIV-1 v krvi in jo zadržuje na nizki ravni.
It is not intended to provide practical advice on how to use Genvoya.
Povzetek ni namenjen zagotavljanju praktičnih nasvetov o njegovi uporabi.
Why is Genvoya approved?
Zakaj je bilo zdravilo Genvoya odobreno?
For the full list of all side effects reported with Genvoya, see the package leaflet.
Za celoten seznam neželenih učinkov, o katerih so poročali pri uporabi zdravila Genvoya, glejte navodilo za uporabo.
For practical information about using Genvoya, patients should read the package leaflet or contact their doctor or pharmacist.
Za praktične informacije o uporabi zdravila Genvoya naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
Three of the active substances, elvitegravir, cobicistat and emtricitabine have already been shown to be effective.
Tri od teh zdravilnih učinkovin, elvitegravir, kobicistat in emtricitabin, so se že izkazali za učinkovite.
After 48 weeks a viral load of less than 50 copies/ml was seen in 97% (932 of 959) of patients switched to Genvoya and 93% (444 of 477) of patients who continued with their usual treatment.
Preiskave so po 48 tednih pokazale virusno obremenitev manj kot 50 kopij/ml pri 97 % (932 od 959) bolnikov, ki so prešli na uporabo zdravila Genvoya, in 93 % (444 od 477) bolnikov, ki so nadaljevali jemanje svojih običajnih zdravil.
In another study, Genvoya was given to adolescents aged 12 to 18 years with HIV-1 infection who had not been treated previously.
V drugi študiji so zdravilo Genvoya dali mladostnikom, starim 12 do 18 let, okuženim z virusom HIV-1, ki niso bili predhodno zdravljeni.
Tenofovir alafenamide is a ‘prodrug' of tenofovir, meaning that it is converted into the active substance tenofovir in the body.
Alafenamidtenofovirat je „predzdravilo“ tenofovirja, kar pomeni, da se v zdravilno učinkovino tenofovir pretvori v telesu.
Genvoya can also be used in children aged over 6 years who cannot tolerate other HIV-1 treatments because of side effects.
Zdravilo Genvoya se lahko uporablja tudi pri otrocih, starejših od šest let, ki zaradi neželenih učinkov ne morejo prenašati drugih zdravil za zdravljenje okužb z virusom HIV-1.
Cobicistat increases the level of elvitegravir by slowing its breakdown.
Kobicistat poviša raven elvitegravirja v krvi, tako da upočasni njegov razkroj.
The medicine can only be obtained with a prescription and treatment should be started by a doctor who is experienced in managing HIV infection.
Predpisovanje in izdaja zdravila Genvoya je le na recept, zdravljenje pa mora uvesti zdravnik z izkušnjami z zdravljenjem okužb z virusom HIV.
Elvitegravir is a type of antiviral agent called an ‘integrase inhibitor'.
Elvitegravir je vrsta protivirusnega sredstva, imenovanega „zaviralec integraze“.
Tenofovir alafenamide had a milder effect on the kidney than tenofovir disoproxil.
Alafenamidtenofovirat je imel blažji učinek na ledvice kot dizoproksiltenofovirat.
In studies, the effectiveness of Genvoya was high and comparable to that of a medicine containing elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil.
V študijah je bila učinkovitost zdravila Genvoya visoka in primerljiva z zdravilom, ki vsebuje elvitegravir, kobicistat, emtricitabin in dizoproksiltenofovirat.
Tenofovir and emtricitabine are related antiviral agents called reverse transcriptase inhibitors.
Tenofovir in emtricitabin sta sorodni protivirusni učinkovini, ki spadata med zaviralce reverzne transkriptaze.
In both studies, Genvoya was compared with another antiviral medicine which contained the active ingredients elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil.
V obeh študijah so zdravilo Genvoya primerjali z drugim protivirusnim zdravilom, ki je vsebovalo zdravilne učinkovine elvitegravir, kobicistat, emtricitabin in dizoproksiltenofovirat.
How does Genvoya work?
Kako zdravilo Genvoya deluje?
How is Genvoya used?
Kako se zdravilo Genvoya uporablja?
Genvoya contains the active substances elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide.
Zdravilo Genvoya vsebuje zdravilne učinkovine elvitegravir, kobicistat, emtricitabin in alafenamidtenofovirat.
Long-term safety data in children and adolescents are not available.
Dolgoročnih podatkov o varnosti pri otrocih in mladostnikih ni na voljo.
The remaining 10 countries do not currently have wording to this effect.
V preostalih 10 državah v zvezi s tem trenutno ni besedila.
In all other EU-countries, approval has been granted through national procedures.
V vseh drugih državah EU je bilo zdravilo odobreno z nacionalnimi postopki.
In all cases the results were within the approved specifications.
V vseh primerih so bili rezultati v mejah odobrenih specifikacij.
Arimidex was first approved on 1995 in the UK and via a MRP procedure in Austria, Germany, Italy, Portugal and Spain.
Zdravilo Arimidex je bilo prvič odobreno leta 1995 v Združenem kraljestvu in s postopkom z medsebojnim priznavanjem v Avstriji, Nemčiji, Italiji, na Portugalskem in v Španiji.
Section 4.8 Undesirable effects
Poglavje 4.8 Neželeni učinki
The list of manufacturers in the harmonised version of the dossier has been updated and the sites no longer in use have not been included.
Seznam proizvajalcev v usklajeni različici dokumentacije je bil posodobljen in lokacije, ki se ne uporabljajo več, niso bile vključene.
Identical wording for this indication exists in 19 out of the 29 countries where Arimidex is approved.
Enako besedilo za to indikacijo je v 19 od 29 držav, v katerih je zdravilo Arimidex odobreno.
Treatment should be based on a benefit-risk evaluation for the individual patient.
Zdravljenje mora temeljiti na oceni razmerja med tveganji in koristmi za vsakega posameznega bolnika.
Overall summary of the scientific evaluation of Arimidex
Splošni povzetek znanstvenega vrednotenja zdravila Arimidex
Estrone is subsequently converted to estradiol.
Estron se naknadno pretvori v estradiol.
Section 4.6 Fertility, pregnancy and lactation
Poglavje 4.6 Plodnost, nosečnost in dojenje
General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.
Indicirana je splošna podporna oskrba, vključno s pogostim spremljanjem življenjskih znakov in skrbnim opazovanjem bolnika.
The effect of potent CYP inhibitors is unknown.
Učinek močnih zaviralcev CYP je neznan.
Clinical aspects
Klinični vidiki
The Committee considered that most of the contraindications proposed were not appropriate as such, given that they reflected the lack of relevant data rather than absolute contraindications.
Odbor je menil, da večina predlaganih kontraindikacij ni ustreznih, saj so odražale predvsem pomanjkanje ustreznih podatkov in ne absolutne kontraindikacije.
Arimidex tablets are very stable under the conditions recommended in the product information, i.e. “store under 30°C”
Tablete zdravila Arimidex so zelo stabilne pod pogoji, ki so priporočeni v informacijah o zdravilu, na primer „shranjujte pri temperaturi pod 30 °C“.
There is no specific antidote to overdose and treatment must be symptomatic.
Za preveliko odmerjanje ni posebnega antidota, zdravljenje pa mora biti simptomatsko.
• Patients with known hypersensitivity to anastrozole or to any of the excipients as referenced in section 6.1.
• bolnikih z znano preobčutljivostjo za anastrozol ali katero koli pomožno snov, ki so navedene v poglavju 6.1.
The wording for this section did not significantly differ between countries.
Besedilo v tem poglavju se med posameznimi državami ni bistveno razlikovalo.
One of the main inclusion criteria for this study was histologically proven operable invasive breast cancer.
Eno od glavnih meril za vključitev v to študijo je bil histološko dokazan operabilen invazivni rak dojke.
Anastrozole inhibits CYPs 1A2, 2C8/9 and 3A4 in vitro.
Anastrozol in vitro zavira encime CYP 1A2, 2C8/9 in 3A4.
A subheading on fertility was also introduced.
Vključeno je bilo tudi podpoglavje o plodnosti.
• Pregnant or breast-feeding women.
• nosečih ali doječih ženskah;
The MAH presented a proposal for section 4.3 which was based on the currently existing contraindications in the different countries.
Imetnik dovoljenja za promet z zdravilom je predstavil predlog za poglavje 4.3, ki je bil zasnovan na trenutno obstoječih kontraindikacijah v različnih državah.
The majority of the Member States currently have the same wording or wording within the same meaning with respect of this indication.
V zvezi s to indikacijo ima trenutno večina držav članic enako besedilo oziroma besedilo z enakim pomenom.
In the management of an overdose, consideration should be given to the possibility that multiple agents may have been taken.
V primeru prevelikega odmerjanja je treba upoštevati tudi možnost, da je bilo uporabljenih več zdravil.
The wording on posology did not differ significantly across Member States, but recommendations on use in renal and hepatic impairment were not harmonised.
Besedilo o odmerjanju se med državami članicami ni bistveno razlikovalo, vendar priporočila o uporabi pri okvari ledvic in jeter niso bila usklajena.
Other changes were introduced in the description of the clinical trials supporting the indication to clarify and streamline the information for the prescriber.
V opis kliničnih preskušanj so bile dodane druge spremembe, ki podpirajo to indikacijo, za pojasnitev in poenostavitev informacij za predpisovalce.
‘Premenopausal women' and ‘patients with concomitant tamoxifen therapy' were deleted from this section and information moved to section 4.4.
„Ženske pred menopavzo“ in „bolniki s sočasno terapijo s tamoksifenom“ so bili iz tega poglavja izbrisani, informacije pa prestavljene v poglavje 4.4.
This was accepted but may need to be revised in the future as a consequence of an ongoing procedure under Art. 45 of Regulation 1901/2006 as amended specifically to assess this data.
To je bilo sprejeto, vendar bo morda potreben popravek zaradi trenutno potekajočega postopka za ocenjevanje teh podatkov, ki poteka v skladu s členom 45 Uredbe 1901/2006, kakor je bila spremenjena.
Quality aspects
Vidiki kakovosti
Arimidex is contraindicated in:
Zdravilo Arimidex je kontraindicirano pri:
The Committee considered that available study results and current scientific knowledge allow for more detailed and informative wording on the potential for cytochrome P450 interactions.
Odbor je menil, da razpoložljivi rezultati študij in trenutno znanstveno znanje omogočajo natančnejše in bolj informativno besedilo o možnih interakcijah zaradi citokroma P450.
The active substance is stable under the conditions specified in the dossier.
Zdravilna učinkovina je v pogojih, opredeljenih v dokumentaciji, stabilna.
Hypersensitivity to lactose
Preobčutljivost za laktozo
Effect on bone mineral density
Vpliv na mineralno gostoto kosti
The indications were essentially the same but worded differently in the various countries.
Indikacije v različnih državah so bile v bistvu enake, vendar so imele drugačno besedilo.
In animal studies, anastrozole demonstrated low acute toxicity.
V študijah pri živalih se je pokazala nizka akutna toksičnost anastrozola.
Stability data from production scale batches of the active substance and drug product which was already approved in some member states was presented.
Predstavljeni so bili podatki o stabilnosti iz proizvodnih serij zdravilne učinkovine in zdravila, ki je bilo v nekaterih državah članicah že odobreno.
There were no clinically significant interactions with bisphosphonates (see section 5.1).
Prav tako ni bilo klinično pomembnih interakcij z bisfosfonati (glejte poglavje 5.1).
Due to the divergent national decisions taken by Member States concerning the authorisation of the above-mentioned product,the European Commission notified the CHMP/European Medicines Agency of an official referral under Article 30 of Directive 2001/83/EC as amended, in order to resolve divergences amongst the nationally authorised SPCs and thus to harmonise its divergent SPCs across the EU.
Zaradi različnih nacionalnih odločitev držav članic o odobritvi dovoljenj za promet z navedenim zdravilom (in povezanimi imeni) je Evropska komisija obvestila CHMP/Evropsko agencijo za zdravila o uradni napotitvi v skladu s členom 30 Direktive 2001/83/ES, kakor je bila spremenjena, da bi se razrešile razlike med nacionalno odobrenimi povzetki glavnih značilnosti zdravila in s tem uskladili različni povzetki glavnih značilnosti zdravila v EU.
In postmenopausal women, estradiol is produced primarily from the conversion of androstenedione to estrone through the aromatase enzyme complex in peripheral tissues.
Pri ženskah po menopavzi se estradiol proizvaja predvsem s pretvorbo androstenediona v estron z encimskim kompleksom aromataze v perifernih tkivih.