natgillin/translations-raw huggingface dataset:
Very common side effects (may affect more than 1 in 10 people) - skin rash.
Zelo pogosti neželeni učinki (pojavijo se pri več kot 1 od 10 bolnikov) - kožni izpuščaj, ki je običajno blag do zmeren.
PLATELET AGGREGGATION INHIBITORS Clopidogrel
ZAVIRALCI AGREGACIJE TROMBOCITOV klopidogrel
Uncommon side effects (may affect up to 1 in 100 people) - decreased number of white blood cells; - symptoms of infection (for example enlarged lymph nodes and fever); - abnormal dreams, confusion, disorientation, nervousness, nightmares; - drowsiness, trembling, fainting, seizures, disturbance in attention; - dizziness, sluggishness; - angina, irregular heart rhythm; - difficulty breathing; - retching, inflammation of the pancreas, vomiting blood; - liver problems such as hepatitis, enlarged liver; - excessive sweating, swelling of the face and/or throat; - swelling of breasts in men.
Občasni neželeni učinki (pojavijo se pri največ 1 od 100 bolnikov) - zmanjšano število levkocitov - simptomi okužbe (na primer povečane bezgavke ali zvišana telesna temperatura) - nenormalne sanje, zmedenost, dezorientacija, živčnost, nočne more - dremavost, tresenje, omedlevica, epileptični napadi, motnje pozornosti - omotica, upočasnjenost - angina pektoris, motnje srčnega ritma - težave z dihanjem - siljenje na bruhanje, vnetje trebušne slinavke, bruhanje krvi - jetrne bolezni, npr. hepatitis, povečana jetra - prekomerno potenje, otekanje obraza in/ali žrela - zvečanje prsi pri moških.
Fluvastatin, and rosuvastatin are metabolised by CYP2C9 and co-administration with etravirine may result in higher plasma concentrations of the HMG Co-A reductase inhibitor.
Fluvastatin in rosuvastatin se presnavljata s CYP2C9 in njuna sočasna uporaba z etravirinom lahko vodi do večjih plazemskih koncentracij zaviralca HMG Co-A reduktaze.
INTELENCE can be used with these NRTIs without dose adjustment.
INTELENCE se skupaj s temi NRTI lahko uporablja brez prilagajanja odmerkov.
How to store INTELENCE
Shranjevanje zdravila INTELENCE
Rash was mostly self-limiting and generally resolved within 1 week on continued therapy.
Večinoma je bil omejen in je ob nadaljevanju zdravljenja izginil v enem tednu.
Boosted protease inhibitors, like darunavir/ritonavir, show a higher barrier to resistance compared to other classes of antiretrovirals.
darunavir/ritonavir), višjo mejo za razvoj odpornosti.
Rash was most frequently mild to moderate, generally macular to maculopapular or erythematous, mostly occurred in the second week of therapy, and was infrequent after week 4.
Izpuščaj je bil najpogosteje blag do zmeren, običajno je bil makularen do makulopapularen ali eritematozen.
The effect of etravirine on dolutegravir plasma concentrations was mitigated by co-administration of darunavir/ritonavir or lopinavir/ritonavir, and is expected to be mitigated by atazanavir/ritonavir.
Učinek etravirina na koncentracijo dolutegravirja v plazmi je ublažila sočasna kombinacija darunavir/ritonavir ali lopinavir/ritonavir.
The patient should be instructed to do the following: - place the tablet(s) in 5 ml (1 teaspoon) of water, or at least enough liquid to cover the medicine, - stir well until the water looks milky, - if desired, add more water or alternatively orange juice or milk (patients should not place the tablets in orange juice or milk without first adding water), - drink it immediately, - rinse the glass several times with water, orange juice, or milk and completely swallow the rinse each time to make sure the patient takes the entire dose.
(e) z vodo, - dobro premeša tako, da voda izgleda kot mleko, - po želji doda vodo, pomarančni sok ali mleko (tablet ne sme dati neposredno v pomarančni sok ali mleko), - takoj popije, - kozarec večkrat spere z vodo, pomarančnim sokom ali mlekom in vsakič popije tudi vso tekočino, s katero je spral kozarec, da bo prejel celotni odmerek.
Gastrointestinal very common diarrhoea, nausea disorders common gastrooesophageal reflux disease, vomiting, abdominal pain, abdominal distension, flatulence, gastritis, constipation, dry mouth, stomatitis, lipase increased, blood amylase increased uncommon pancreatitis, haematemesis, retching Hepatobiliary disorders common increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST) uncommon hepatitis, hepatic steatosis, cytolytic hepatitis, hepatomegaly
Bolezni prebavil zelo pogosti driska, navzea pogosti gastroezofagealni refluks, bruhanje, trebušne bolečine, napihnjenost trebuha, napenjanje, gastritis, zaprtje, suha usta, stomatitis, zvečanje koncentracije lipaze, zvečanje koncentracije amilaze v krvi občasni pankreatitis, hematemeza, siljenje na bruhanje
This combination can be used without dose adjustment.
Pri teh kombinacijah prilagoditev odmerka ni potrebna.
nd trimester of pregnancy as compared to postpartum, and 1.1-, 1.4- and 1.2-fold higher, respectively, based during the 3
Primerjava med posameznimi bolnicami je pokazala, da so bile vrednosti Cmin, Cmax in AUC12h za 1,2-; 1,4- oziroma 1,4-krat večje med drugim trimesečjem nosečnosti in za 1,1-; 1,4- oziroma 1,2-krat večje med tretjim trimesečjem nosečnosti v primerjavi z obdobjem po porodu.
Each tablet contains 160 mg of lactose monohydrate.
Ena tableta vsebuje 160 mg laktoze monohidrata.
If a patient misses a dose by more than 6 hours of the time it is usually taken, the patient should not take the missed dose and simply resume the usual dosing schedule.
Če zamudi jemanje odmerka za več kot 6 ur od običajnega časa, naj preskoči zamujeni odmerek in preprosto nadaljuje z običajnim jemanjem zdravila.
Each tablet contains 40 mg of lactose monohydrate.
Ena tableta vsebuje 40 mg laktoze monohidrata.
Etravirine was not carcinogenic in rats and in male mice.
V preskušanjih na podganah in samcih miši etravirin ni bil kancerogen.
ANTIMYCOBACTERIALS Rifampicin
UČINKOVINE ZA ZDRAVLJENJE INFEKCIJ Z MIKOBAKTERIJAMI rifampicin rifapentin
HIV-1 RNA log10 mean change from baseline (log10 copies/ml) CD4 cell count mean change from baseline (x 10
Srednja vrednost spremembe HIV-1 RNK log10 glede na začetno vrednost (log10 kopij/ml) Srednja vrednost spremembe števila celic CD4 glede na začetno vrednost (x 10
Saquinavir/ritonavir 1,000/100 mg twice daily saquinavir
sakvinavir/ritonavir 1.000/100 mg dvakrat na dan sakvinavir
It is not recommended to co-administer INTELENCE with indinavir.
Sočasna uporaba zdravila INTELENCE z indinavirjem ni priporočljiva.
Interactions with medicinal products
Medsebojno delovanje z drugimi zdravili
Please refer to the product information of the associated boosted PI for the dose adjustment of rifabutin to be used.
Za navodila za prilagajanje odmerka rifabutina, glejte navodila za uporabo sočasno uporabljenega okrepljenega PI.
Etravirine 200 mg twice daily postpartum N = 10
200 mg etravirina dvakrat na dan, po porodu N = 10
What INTELENCE looks like and contents of the pack This medicinal product is presented as white to off-white, oval tablet, with “T125” on one side and “100” on the other side.
Izgled zdravila INTELENCE in vsebina pakiranja Bela do belkasta ovalna tableta z oznako “T125” na eni strani in “100” na drugi.
Change from baseline in log10 viral load (copies/ml) at week 24, mean (SE) and median (range)
Sprememba log10 virusnega bremena (št. kopij/ml) po 24. tednu (glede na začetek), povprečje (SE) in mediana (razpon)
Rash was mostly self-limiting and generally resolved within 1 to 2 weeks on continued therapy.
V večini primerov je bil omejen in je ob nadaljevanju zdravljenja običajno minil v 1 do 2 tednih.
INTELENCE has not been studied in patients with severe hepatic impairment (Child-Pugh Class C) and is therefore not recommended (see sections 4.2 and 4.4).
Pri bolnikih s hudo okvaro jeter (razred C po klasifikaciji Child-Pugh) zdravila INTELENCE niso proučevali, zato uporaba zdravila pri njih ni priporočljiva (glejte poglavji 4.2 in 4.4).
Each tablet contains 40 mg lactose (as monohydrate).
Ena tableta vsebuje 40 mg laktoze (v obliki monohidrata).
Integrase Strand Transfer Inhibitors Dolutegravir
Zaviralci prenosa virusnega genoma s pomočjo encima integraze dolutegravir
Hypromellose Microcrystalline cellulose Colloidal anhydrous silica Croscarmellose sodium Magnesium stearate Lactose monohydrate
INTELENCE 100 mg tablete hipromeloza mikrokristalna celuloza koloidni brezvodni silicijev dioksid premreženi natrijev karmelozat magnezijev stearat laktoza monohidrat
It is therefore possible that etravirine may inhibit the metabolism of clopidogrel to its active metabolite by such inhibition of CYP2C19 in vivo.
Zato je mogoče, da etravirin z zaviranjem CYP2C19 in vivo zavira presnovo klopidogrela v njegov aktivni presnovek.
Each tablet contains 160 mg lactose (as monohydrate).
Ena tableta vsebuje 160 mg laktoze (v obliki monohidrata).
A plastic bottle containing 60 tablets and 3 pouches to keep the tablets dry.
Plastenka s 60 tabletami in 3 blazinicami s sušilnim sredstvom za tablete.
White to off-white, oval, scored tablet, debossed with “TMC” on one side.
Bela do belkasta ovalna tableta z razdelilno zarezo in vtisnjeno oznako “TMC” na eni strani.
A decreased virologic response to etravirine was observed in patients with viral strains harbouring 3 or more among the following mutations V90I, A98G, L100I, K101E/P, V106I, V179D/F, Y181C/I/V, and G190A/S (see section 5.1).
Pri bolnikih z virusnimi sevi, ki so vsebovali 3 ali več naslednjih mutacij: V90I, A98G, L100I, K101E/P, V106I, V179D/F, Y181C/I/V in G190A/S, so opazili zmanjšan virološki odziv na etravirin (glejte poglavje 5.1).
It is part of a treatment reducing the amount of virus in the blood.
Zdravilo INTELENCE ne more ozdraviti okužbe s HIV, ampak sodi v okvir zdravljenja za zmanjševanje količine virusa v krvi.
Geometric Mean ± Standard Deviation Median (Range)
AUC12h (ngh/ml) geometrična sredina ± standardna deviacija mediana vrednost (območje) C0h (ng/ml) geometrična sredina ± standardna deviacija mediana vrednost (območje)
The bottle is a high-density polyethylene (HDPE) plastic bottle containing 60 tablets and 3 desiccant pouches, fitted with a polypropylene (PP) child resistant closure.
Plastenka iz polietilena velike gostote (HDPE) vsebuje 60 tablet, 3 blazinice s sušilnim sredstvom in je opremljena s polipropilensko (PP) zaporko, varno za otroke.
No interaction is expected for either INTELENCE or enfuvirtide when co-administered.
Pri sočasni uporabi zdravila INTELENCE in enfuvirtida ni pričakovati medsebojnih delovanj.
AUC12h (ng•h/ml) Geometric Mean ± Standard Deviation Median (Range) C0h (ng/ml) Geometric Mean ± Standard Deviation Median (Range) * All HIV-1 infected subjects enrolled in Phase III clinical trials received darunavir/ritonavir 600/100 mg twice daily as part of their background regimen.
* Vsi s HIV-1 okuženi preskušanci vključeni v klinična preskušanja III. faze so kot del osnovne sheme zdravljenja prejeli darunavir/ritonavir 600/100 mg dvakrat na dan.
HIV PIs - Boosted with cobicistat Atazanavir/cobicistat Darunavir/cobicistat
HIV PI (zaviralci proteaze) - okrepljeni s kobicistatom atazanavir/kobicistat darunavir/kobicistat
The bottle is a high-density polyethylene (HDPE) plastic bottle containing 120 tablets and 2 desiccant pouches, fitted with a polypropylene (PP) child resistant closure.
Plastenka iz polietilena velike gostote (HDPE) vsebuje 120 tablet, 2 blazinici s sušilnim sredstvom in je opremljena s polipropilensko (PP) zaporko, varno za otroke.
INTELENCE and raltegravir can be used without dose adjustments.
Zdravilo INTELENCE in raltegravir se lahko uporabljata brez prilagajanja odmerkov.
Tablet White to off-white, oval tablet debossed with “T125” on one side and “100” on the other side.
INTELENCE 100 mg tablete tableta Bela do belkasta ovalna tableta z vtisnjeno oznako “T125” na eni strani in “100” na drugi.
INTELENCE and atazanavir/ritonavir can be used without dose adjustment.
Zdravilo INTELENCE in kombinacija atazanavir/ritonavir se lahko uporabljajo brez prilagajanja odmerkov.
HIV Protease Inhibitors (PIs) - Unboosted (i.e. without co-administration of low-dose ritonavir) Indinavir
HIV PI (zaviralci proteaze) - neokrepljeni (t.j.
A plastic bottle containing 120 tablets and 2 pouches to keep the tablets dry.
Plastenka s 120 tabletami in 2 blazinicama s sušilnim sredstvom za tablete.
Etravirine is expected to increase plasma concentrations of diazepam.
Pričakovati je, da etravirin zviša plazemsko koncentracijo diazepama.
amnesia, somnolence uncommon convulsion, syncope, tremor, hypersomnia, disturbance in attention
Bolezni živčevja zelo pogosti glavobol pogosti periferna nevropatija, parestezije, hipestezija, amnezija, somnolenca občasni konvulzije, sinkopa, tremor, hipersomnija, motnje pozornosti
Combination not recommended.
Sočasna uporaba ni priporočljiva.
INTELENCE and these antifungals can be used without dose adjustments.
Zdravilo INTELENCE in navedeni antimikotiki se lahko uporabljajo brez prilagajanja odmerkov.
INTELENCE and didanosine can be used without dose adjustments.
INTELENCE in didanozin se lahko uporabljata brez prilagajanja odmerkov.
Renal and urinary disorders common renal failure, blood creatinine increased
Bolezni sečil pogosti ledvična odpoved, zvečanje koncentracije kreatinina v krvi
INTELENCE can be co-administered with proton pump inhibitors without dose adjustments.
Zdravilo INTELENCE lahko uporabljate sočasno z zaviralci protonske črpalke brez prilagoditve odmerka.
0.035 mg once daily
0,035 mg enkrat na dan noretisteron
Each tablet contains 25 mg etravirine.
Ena tableta vsebuje 25 mg etravirina.
The bottle is a high-density polyethylene (HDPE) plastic bottle containing 120 tablets and 3 desiccant pouches, fitted with a polypropylene (PP) child resistant closure.
Plastenka iz polietilena velike gostote (HDPE) vsebuje 120 tablet, 3 blazinice s sušilnim sredstvom in je opremljena s polipropilensko (PP) zaporko, varno za otroke.
INTELENCE and fluconazole can be used without dose adjustments.
Zdravilo INTELENCE in flukonazol se lahko uporabljata brez prilagajanja odmerkov.
AUC ↓ 0.83 (0.75-0.94) Cmin ↓ 0.76 (0.66-0.87) Cmax ↓ 0.90 (0.78-1.03) 25-O-desacetyl-rifabutin AUC ↓ 0.83 (0.74-0.92) Cmin ↓ 0.78 (0.70-0.87) Cmax ↓ 0.85 (0.72-1.00) etravirine
AUC ↓ 0,83 (0,75-0,94) Cmin ↓ 0,76 (0,66-0,87) Cmax ↓ 0,90 (0,78-1,03) 25-O-deacetil-rifabutin AUC ↓ 0,83 (0,74-0,92) Cmin ↓ 0,78 (0,70-0,87) Cmax ↓ 0,85 (0,72-1,00) etravirin
Parameter
Presnovni parametri
Etravirine is expected to increase plasma concentrations of warfarin.
Pričakovati je, da etravirin zviša plazemsko koncentracijo varfarina.
A plastic bottle containing 120 tablets and 3 pouches to keep the tablets dry.
Plastenka s 120 tabletami in 3 blazinicami s sušilnim sredstvom za tablete.
No dose adjustment is suggested in patients with mild or moderate hepatic impairment (Child-Pugh Class A or B); INTELENCE should be used with caution in patients with moderate hepatic impairment.
Pri bolnikih z blago do zmerno okvaro jeter (razred A ali B po klasifikaciji Child-Pugh) ni potrebno prilagajati odmerka.
Common side effects (may affect up to 1 in 10 people) - allergic reactions (hypersensitivity); - diabetes, decrease of appetite; - anxiety, sleepiness, sleeplessness, sleep disorders; - tingling or pain in hands or feet, numbness, loss of skin sensibility, loss of memory tiredness; - blurred vision; - kidney failure, high blood pressure, heart attack, shortness of breath when exercising; - vomiting, heartburn, abdominal pain, distension of the abdomen, inflammation of the stomach,
Pogosti neželeni učinki (pojavijo se pri največ 1 od 10 bolnikov) - alergijske reakcije (preobčutljivost) - sladkorna bolezen, zmanjšan apetit - tesnoba, zaspanost, nespečnost, motnje spanja - mravljinci ali bolečine v dlaneh in stopalih, občutek odrevenelosti, izguba občutljivosti kože,
Even if you feel better, do not stop taking INTELENCE or your other anti-HIV medicines.
Med zdravljenjem okužbe z virusom HIV se boste lahko začeli počutiti bolje, vendar kljub temu ne smete prenehati z jemanjem zdravila INTELENCE in drugih zdravil proti temu virusu, ker bi lahko s tem povečali tveganje za razvoj odpornosti virusa na zdravilo.
INTELENCE and azithromycin can be used without dose adjustments.
Zdravilo INTELENCE in azitromicin se lahko uporabljata brez prilagajanja odmerkov.
What INTELENCE looks like and contents of the pack This medicinal product is presented as white to off-white, oval, scored tablet, with “TMC” on one side.
Izgled zdravila INTELENCE in vsebina pakiranja Bela do belkasta ovalna tableta, z razdelilno zarezo in oznako “TMC” na eni strani.
Each tablet of INTELENCE contains 25 mg of etravirine.
Ena tableta zdravila INTELENCE vsebuje 25 mg etravirina.
Swallow the INTELENCE tablet(s) whole with a glass of water.
Tableto (tablete) zdravila INTELENCE morate pogoltniti celo (cele) s kozarcem vode in je (jih) ne smete žvečiti.
Each tablet contains 100 mg etravirine.
Ena tableta vsebuje 100 mg etravirina.
Each tablet contains 200 mg etravirine.
Ena tableta vsebuje 200 mg etravirina.
Etravirine is expected to increase nelfinavir plasma concentrations.
Pričakovati je, da etravirin zviša plazemske koncentracije nelfinavirja.
NNRTIs Efavirenz Nevirapine Rilpivirine
NNRTI (nenukleozidni zaviralci reverzne transkriptaze) efavirenz nevirapin rilpivirin
Each tablet of INTELENCE contains 100 mg of etravirine.
Ena tableta zdravila INTELENCE vsebuje 100 mg etravirina.
200 mg twice daily eight 25 mg tablets twice daily or two 100 mg tablets twice daily or one 200 mg tablet twice daily
200 mg dvakrat na dan osem 25 mg tablet dvakrat na dan ali dve 100 mg tableti dvakrat na dan ali ena 200 mg tableta dvakrat na dan
What INTELENCE looks like and contents of the pack This medicinal product is presented as white to off-white, biconvex, oblong tablet with “T200” on one side.
Izgled zdravila INTELENCE in vsebina pakiranja Bela do belkasta, bikonveksna, podolgovata tableta z oznako “T200” na eni strani.
Fusion Inhibitors Enfuvirtide 90 mg twice daily etravirine*
90 mg dvakrat na dan etravirin*
Proportion of subjects with HIV-1 RNA < 50 copies/ml at week 48
Odstotek preiskovancev s HIV-1 RNK < 50 kopij/ml v 48. tednu etravirin + BR N = 599
Norethindrone
didanozin
In the morning, take two 100 milligram INTELENCE tablets, following a meal.
Zjutraj vzemite dve 100 miligramski tableti zdravila INTELENCE po jedi.
Most often, rash was mild to moderate, of macular/papular type, and occurred in the second week of therapy.
Izpuščaj se je najpogosteje pojavil v drugem tednu zdravljenja, bil je blag, makularno /papilarenega tipa.
Each tablet of INTELENCE contains 200 mg of etravirine.
Ena tableta zdravila INTELENCE vsebuje 200 mg etravirina.
All ranges * Etravirine RAMs = V90I, A98G, L100I, K101E/P, V106I, V179D/F, Y181C/I/V, G190A/S
* RAMi etravirina = V90I, A98G, L100I, K101E/P, V106I, V179D/F, Y181C/I/V, G190A/S Opomba: Vsi bolniki iz preskušanj DUET so prejemali osnovno shemo: darunavir/ritonavir, NRTI po izbiri raziskovalca in enfuvirtid po izbiri.
Silicified microcrystalline cellulose Microcrystalline cellulose Colloidal anhydrous silica Croscarmellose sodium Magnesium stearate
INTELENCE 200 mg tablete hipromeloza silicirana mikrokristalna celuloza mikrokristalna celuloza koloidni brezvodni silicijev dioksid premreženi natrijev karmelozat magnezijev stearat
(Hypericum perforatum)
ZDRAVILA RASTLINSKEGA IZVORA Šentjanževka (Hypericum perforatum)
Severe cutaneous adverse reactions have been reported with etravirine.
Pri uporabi etravirina so poročali tudi o hudih kožnih neželenih reakcijah.
INTELENCE and lopinavir/ritonavir can be used without dose adjustments.
Zdravilo INTELENCE in kombinacija lopinavir/ritonavir se lahko uporabljajo brez prilagajanja odmerkov.
125 mg twice daily five 25 mg tablets twice daily or one 100 mg tablet and one 25 mg tablet twice daily
≥ 20 do < 25 kg 125 mg dvakrat na dan pet 25 mg tablet dvakrat na dan ali ena 100 mg tableta in ena 25 mg tableta dvakrat na dan
The combination of INTELENCE and ribavirin can be used without dose adjustments.
Zdravilo INTELENCE in ribavirin se lahko uporabljata brez prilagajanja odmerkov.
No data other than drug-drug interaction data (see section 4.5) are available when etravirine is combined with raltegravir or maraviroc.
Podatki o kombiniranju etravirina z raltegravirjem ali maravirokom niso na voljo, razen tistih, ki zadevajo medsebojno delovanje zdravil (glejte poglavje 4.5).
It is recommended that the international normalised ratio (INR) be monitored when warfarin is combined with INTELENCE.
Pri kombiniranju varfarina z zdravilom INTELENCE je priporočljivo, da spremljate protrombinski čas (INR).
The bottle contains 2 little pouches (desiccants) to keep the tablets dry.
Plastenka vsebuje tudi 2 majhni blazinici (sušilno sredstvo za sušenje tablet), ki morata ostati v plastenki ves čas in ju ne smete zaužiti.
150 mg twice daily six 25 mg tablets twice daily or one 100 mg tablet and two 25 mg tablets twice daily
≥ 25 do < 30 kg 150 mg dvakrat na dan šest 25 mg tablet dvakrat na dan ali ena 100 mg tableta in dve 25 mg tableti dvakrat na dan
Using the oral solution may be considered for dose reduction.
Pri prilagajanju odmerka si lahko pomagate z uporabo peroralne raztopine.
If a rash occurs, it usually appears soon after anti-HIV treatment with INTELENCE is started and often disappears within 1 to 2 weeks, even with continued use of the medicine.
Pogosto tak izpuščaj izgine v 1 do 2 tednih kljub nadaljnji uporabi zdravila.
INTELENCE and digoxin can be used without dose adjustments.
Zdravilo INTELENCE in digoksin lahko uporabljate brez prilagoditve odmerka.
In the evening, take two 100 milligram INTELENCE tablets, following a meal.
Zvečer vzemite dve 100 miligramski tableti zdravila INTELENCE po jedi.
INTELENCE can be co-administered with paroxetine without dose adjustments.
Zdravilo INTELENCE lahko uporabljate sočasno s paroksetinom brez prilagoditve odmerka.
Tablet White to off-white, biconvex, oblong tablet debossed with “T200” on one side.
INTELENCE 200 mg tablete tableta Bela do belkasta bikonveksna ovalna tableta z vtisnjeno oznako “T200” na eni strani.
Fosamprenavir/ritonavir 700/100 mg twice daily amprenavir
700/100 mg dvakrat na dan amprenavir
The bottle contains 3 little pouches (desiccants) to keep the tablets dry.
Plastenka vsebuje tudi 3 majhne blazinice (sušilno sredstvo za sušenje tablet), ki morajo ostati v plastenki ves čas in jih ne smete zaužiti.
INTELENCE and saquinavir/ritonavir can be used without dose adjustments.
Zdravilo INTELENCE in kombinacija sakvinavir/ritonavir se lahko uporabljajo brez prilagajanja odmerkov.
Co-administration of Intelence and daclatasvir is not recommended.
Sočasna uporaba zdravila INTELENCE in daklatasvirja ni priporočljiva.
Etravirine 200 mg twice daily 2
vorikonazol 200 mg dvakrat na dan vorikonazol
Co-administration of etravirine with daclatasvir may decrease daclatasvir concentrations.
Sočasna uporaba etravirina in daklatasvirja lahko zmanjša koncentracije daklatasvirja.
Eye disorders common blurred vision
Očesne bolezni občasni zamegljen vid
1 mg once daily ethinylestradiol AUC ↑ 1.22 (1.13-1.31) Cmin ↔ 1.09 (1.01-1.18) Cmax ↑ 1.33 (1.21-1.46) norethindrone AUC ↔ 0.95 (0.90-0.99) Cmin ↓ 0.78 (0.68-0.90) Cmax ↔ 1.05 (0.98-1.12) etravirine
1 mg enkrat na dan etinilestradiol AUC ↑ 1,22 (1,13-1,31) Cmin ↔ 1,09 (1,01-1,18) Cmax ↑ 1,33 (1,21-1,46) noretisteron
Dexamethasone is expected to decrease plasma concentrations of etravirine
Pričakovati je, da pri sočasni uporabi deksametazon zniža plazemsko koncentracijo etravirina.
In the morning, take one 200 milligram INTELENCE tablet, following a meal.
Zjutraj vzemite eno 200 miligramsko tableto zdravila INTELENCE po jedi.
CCR5 Antagonists Maraviroc 300 mg twice daily
Antagonisti CCR5 maravirok
INTELENCE and voriconazole can be used without dose adjustments.
Zdravilo INTELENCE in vorikonazol se lahko uporabljata brez prilagajanja odmerkov.
Baseline characteristics Median plasma HIV-1 RNA 4.8 log10copies/ml
Začetne značilnosti Mediana vrednost HIV-1 RNK v plazmi
In the evening, take one 200 milligram INTELENCE tablet, following a meal.
Zvečer vzemite eno 200 miligramsko tableto zdravila INTELENCE po jedi.
Voriconazole 200 mg twice daily voriconazole AUC ↑ 1.14 (0.88-1.47) Cmin ↑ 1.23 (0.87-1.75) Cmax ↓ 0.95 (0.75-1.21) etravirine
AUC ↑ 1,14 (0,88-1,47) Cmin ↑ 1,23 (0,87-1,75) Cmax ↓ 0,95 (0,75-1,21) etravirin