natgillin/translations-raw huggingface dataset:
Felodipine Cmax and AUC increased 8-fold and 6-fold, respectively, when felodipine was coadministered with the strong CYP3A4 inhibitor itraconazole.
Če je bil felodipin uporabljen sočasno z močnim zaviralcem CYP3A4 itrakonazolom, se je Cmax felodipina povečala za 8-krat in njegova AUC za 6-krat.
Plendil is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed.
Zdravilo Plendil ni priporočljivo za matere, ki dojijo.
CLINICAL PARTICULARS 4.1 Therapeutic indications Hypertension
4.1 Terapevtske indikacije hipertenzija stabilna angina pektoris.
PACKAGE LEAFLET
Velikost pakiranja
LIST OF EXCIPIENTS Contains lactose and polyoxyl 40 hydrogenated castor oil.
Vsebuje laktozo in makrogolglicerol hidroksistearat 40.
The renal vascular resistance is decreased by felodipine.
Felodipin zmanjša upor ledvičnih žil.
QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains 2.5 mg felodipine.
Ena tableta vsebuje 2,5 mg felodipina.
Tablet core:
Preglednica 1.
• Pain in joints
• otekanje gležnjev
Nausea, abdominal pain Vomiting
Bolezni živčevja pogosti občasni glavobol omotica, parestezije
Results are presented above.
Rezultati so predstavljeni zgoraj.
The frequency of these two side effects is not known.
Pogostnost teh dveh neželenih učinkov ni znana.
Stabilization of the symptoms had to be obtained before the end of the first 14 days of each treatment period.
Stabilizacijo simptomov je bilo treba doseči pred koncem prvih 14 dni vsakega obdobja zdravljenja.
Opening date :
Datum odprtja:
Moreover three supportive studies were conducted in 34 paediatric patients.
Poleg tega so opravili tri podporne študije pri 34 pediatričnih bolnikih.
Patients should be instructed not to increase the dosage on their own.
Bolnikom je treba naročiti, naj ne povečujejo odmerka sami.
Difference in LS means (95% confidence limits)
Razlika v povprečnih NK (95 % meje zaupanja)
Approximately half of the patients were ages 1 to 3 years.
Približno pol bolnikov je bilo starih od 1 do 3 let.
No clinically relevant interactions are expected.
Klinično pomembnih interakcij ni pričakovati.
N: number of patients; SD: standard deviation; LS: least squares.
N: število bolnikov; SD: standardna deviacija; NK: najmanjši kvadrati.
If your doctor advises you to increase the number of capsules you take each day, you should do so slowly over several days.
Če vam zdravnik svetuje povečanje števila kapsul, ki jih jemljete vsak dan, morate to narediti počasi, v roku nekaj dni.
Twelve patients completed the study.
Študijo je zaključilo dvanajst bolnikov.
Keep taking your medicine until your doctor tells you to stop.
Zdravilo jemljite, dokler vam zdravnik ne naroči, da prenehajte.
Other reported clinical experience has not identified differences in responses between the elderly and young patients.
Druge klinične izkušnje, o katerih so poročali, ne kažejo na razlike v odzivu med starejšimi in mlajšimi bolniki.
Wait until your next meal, and take your usual number of capsules with your meal.
Počakajte do naslednjega obroka in ob obroku vzemite običajno število kapsul.
You may also sprinkle the granules directly into your child's mouth.
Zrnca lahko stresete tudi neposredno v otrokova usta.
Very common (may affect more than 1 in 10 people): stomach pain.
Zelo pogosti (lahko se pojavijo pri več kot 1 od 10 oseb): bolečine v trebuhu.
Variable statistic
Statistika spremenljivk
The primary objective was to assess the acceptability of 2 modes of administration using an acceptability questionnaire that was completed by the caregiver.
Primarni cilj je bil oceniti sprejemljivost 2 načinov dajanja z vprašalnikom o sprejemljivosti, ki ga je izpolnil negovalec.
Overall, caregivers were satisfied with using apple sauce as a dosing method compared with apple juice.
Na splošno so bili negovalci bolj zadovoljni z uporabo jabolčne čežane kot načina odmerjanja v primerjavi z jabolčnim sokom.
Do not take more capsules in a day than the amount your doctor has told you (total daily dose).
V enem dnevu ne vzemite več kapsul, kot vam jih je priporočil zdravnik (celotni dnevni odmerek).
Changes in dosage may require an adjustment period of several days.
Ob spremembi odmerka bo morda potrebno večdnevno prilagoditveno obdobje.
Anaphylactic shock is a severe, potentially life-threatening allergic reaction that can develop rapidly.
Anafilaktični šok je huda, potencialno smrtno nevarna alergijska reakcija, ki se lahko hitro razvije.
If this reaction occurs, patients should be advised to discontinue treatment immediately and seek urgent medical assistance.
Če nastopi taka reakcija, je treba bolnikom svetovati, naj nemudoma prekinejo zdravljenje in poiščejo nujno zdravniško pomoč.
Standard treatment (N=83)
Standardno zdravilo (N = 83)
The pivotal study PR-005 was conducted in Europe.
Ključna študija PR-005 je bila opravljena v Evropi.
The safety and efficacy in the paediatric patients in this study was similar to the adult patients.
Varnost in učinkovitost pri pediatričnih bolnikih v tej študiji sta bili podobni kot pri odraslih bolnikih.
Other possible side effects may include:
Drugi neželeni učinki so lahko:
Children (over 1 year of age), adolescents and adults
Otroci (starejši od 1 leta), mladostniki in odrasli
If required, carefully open the capsule and administer the contents (granules) to the patient as described in section 4.2.
Po potrebi previdno odprite kapsulo in dajte vsebino (zrnca) bolniku, kot je opisano v poglavju 4.2.
Enzepi is indicated in infants, children, adolescents and adults.
Zdravilo Enzepi je indicirano pri dojenčkih, otrocih, mladostnikih in odraslih.
Therapy should be initiated at the lowest recommended dose and gradually increased under medical supervision with careful monitoring of the patient's response and symptoms.
Zdravljenje je treba začeti z najmanjšim priporočenim odmerkom, ki se postopoma povečuje pod zdravniškim nadzorom ter ob natančnem spremljanju bolnikovega odziva in simptomov.
The mixture must not be stored.
Mešanica se ne sme shraniti.
If you or your child eat a lot of meals or snacks in a day, be careful not to go over your total daily dose of Enzepi.
Če vi ali vaš otrok v enem dnevu pojeste veliko obrokov in prigrizkov, bodite previdni, da ne presežete predpisanega celotnega dnevnega odmerka zdravila Enzepi.
Study PR-018 was a 12-month open-label extension of Study PR-011.
Študija PR-018 je bila 12-mesečno odprto podaljšanje študije PR-011.
Severe allergic reaction
Huda alergijska reakcija
Do not take Enzepi - if you are allergic to the active subtance or any of the other ingredients of this medicine (listed in section 6).
Ne jemljite zdravila Enzepi: če ste alergični na zdravilno učinkovino ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
Patients unable to swallow capsules whole
Bolniki, ki ne morejo pogoltniti cele kapsule
Do not take a double dose or extra capsules to make up for a forgotten dose.
Ne vzemite dvojnega odmerka ali dodatnih kapsul, če ste pozabili vzeti prejšnji odmerek.
There was no wash-out period.
Obdobja izplavljanja ni bilo.
If you are diabetic, you should speak with your doctor, if you notice any changes in your blood glucose levels.
Če ste sladkorni bolnik, se morate posvetovati z zdravnikom, če opazite kakršne koli spremembe v ravni glukoze v krvi.
Adequate caloric intake during pregnancy is important for normal maternal weight gain and foetal growth.
Zadosten vnos kalorij med nosečnostjo je pomemben za normalno materino pridobivanje telesne mase in rast ploda.
Depending on what strength of Enzepi you take, your doctor will tell you how many capsules you need to take with each meal or snack.
Odvisno od tega, katero jakost zdravila Enzepi boste jemali, vam bo zdravnik povedal, koliko kapsul morate vzeti z vsakim obrokom ali prigrizkom.
Do not use this medicine after the expiry date which is stated on the carton and the bottle after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in plastenki poleg oznake »EXP«.
Higher doses should be used with caution if warranted (see sections 4.4 and 4.9) and only if they are documented to be effective by 3day faecal fat measurements that indicate a significantly improved coefficient of fat absorption.
Večje odmerke je treba uporabljati previdno, kadar so res potrebni (glejte poglavji 4.4 in 4.9), in samo, če so dokazano učinkoviti glede na 3-dnevne meritve maščob v blatu, ki kažejo pomembno izboljšan koeficient absorpcije maščob.
No specific adverse reactions were identified in the elderly population.
Pri starejši populaciji niso ugotovili nobenih posebnih neželenih učinkov.
MedDRA System Organ Classification and are ranked under headings of frequency, using the following categories: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000) and not known (cannot be estimated from the available data).
Po pogostnosti so razvrščeni v te kategorije: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000); zelo redki (< 1/10.000) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
Enzepi can only be sprinkled on certain food (see section 3).
Zdravilo Enzepi se sme posuti samo na določeno hrano (glejte poglavje 3).
Look into your child's mouth to make sure that all the medicine has been swallowed.
Poglejte v otrokova usta, da preverite, ali je zaužil celotni odmerek zdravila.
Supportive measures including stopping pancreatic enzyme therapy and ensuring adequate rehydration are recommended.
Priporočajo se podporni ukrepi, vključno s prenehanjem zdravljenja z encimi trebušne slinavke in zagotavljanjem ustrezne rehidracije.
6.6 Special precautions for disposal and other handling Use in paediatric population
6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom Uporaba pri pediatrični populaciji
The difference in means was -1.25 (95% CI, -3.62 to 1.12), with p=0.2972.
Razlika v srednjih vrednostih je bila -1,25 (95 % IZ, od -3,62 do 1,12), p = 0,2972.
Pack size of 20, 50, 100, and 200 capsules.
Velikosti pakiranj: 20, 50, 100 in 200 kapsul.
For each snack, half of the prescribed Enzepi dose for a full meal should be given.
Ob vsakem prigrizku je treba vzeti polovico odmerka zdravila Enzepi, predpisanega za poln obrok.
If this occurs, call for urgent medical attention straightaway.
Če se to zgodi, takoj pokličite nujno zdravniško pomoč.
There are no adequate data from the use of this medicinal product in pregnant women.
O uporabi tega zdravila pri nosečnicah ni ustreznih podatkov.
If an allergic reaction occurs, stop your treatment and talk to your doctor.
Če se pojavi alergijska reakcija, prenehajte z zdravljenjem in se posvetujte z zdravnikom.
Model-based statistics (Enzepi minus Creon) LS mean (standard error)
Statistika na podlagi modela (Enzepi minus Kreon) Povprečni NK (standardna napaka)
Patients were administered Enzepi at the same dose they were taking at the end of Study PR-011.
Bolniki so prejemali zdravilo Enzepi v enakem odmerku kot ob koncu študije PR-011.
OTHER SPECIAL WARNING(S), IF NECESSARY Do not swallow the desiccant.
DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA Ne pogoltnite sušilnega sredstva.
Twelve patients completed both assigned treatment arms and were evaluated.
Dvanajst bolnikov je zaključilo zdravljenje v obeh skupinah in so bili ocenjeni.
Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
V vsaki skupini pogostnosti so neželeni učinki našteti po padajoči resnosti.
Many patients will need to take pancreatic enzyme replacement medicines for the rest of their life.
Številni bolniki bodo morali nadomestna encimska zdravila z encimi trebušne slinavke jemati do konca življenja.
Reduced maternal weight gain and malnutrition can be associated with adverse pregnancy outcomes.
Zmanjšano povečevanje telesne mase matere in podhranjenost sta lahko povezani z neželenimi izidi nosečnosti.
As a precaution, unusual abdominal symptoms or changes in abdominal symptoms should be medically assessed to exclude the possibility of fibrosing colonopathy, especially if the patient is taking in excess of 10,000 lipase units/kg/day.
Kot previdnostni ukrep mora neobičajne trebušne simptome ali spremembe trebušnih simptomov oceniti zdravnik, da se izključi možnost fibrozirajoče kolonopatije, zlasti če bolnik jemlje več kot 10.000 enot lipaze/kg/dan.
What Enzepi is and what it is used for
Kaj je zdravilo Enzepi in za kaj ga uporabljamo
Clinical studies of Enzepi did not include sufficient numbers of subjects aged 65 and over to determine whether they respond different from younger subjects.
Klinične študije z zdravilom Enzepi niso vključevale dovolj preskušancev, starih 65 let in več, da bi bilo mogoče ugotoviti, ali se odzivajo drugače kot mlajši.
The dose is measured in ‘lipase units'.
Odmerek se meri v »enotah lipaze«.
Abnormal blood glucose levels
Nenormalne ravni glukoze v krvi
Paediatric population below 1 year of age
Pediatrična populacija, mlajša od 1 leta
Cystic fibrosis patients
Bolniki s cistično fibrozo
During the study, patients were instructed to consume 100 g (± 15 g) of fat per day and to maintain a consistent dietary fat intake for meals and snacks.
V študiji so bolniki dobili navodila, naj uživajo 100 g (± 15 g) maščob dnevno ter ohranjajo dosleden vnos maščob z obroki in prigrizki.
C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING AUTHORISATION Periodic safety update reports The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
Zahteve glede predložitve rednega posodobljenega poročila o varnosti zdravila za to zdravilo so določene v seznamu referenčnih datumov EU (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES, in vseh kasnejših posodobitvah, objavljenih na evropskem spletnem portalu o zdravilih.
The capsule should be carefully opened to empty the content (granules).
Kapsulo je treba previdno odpreti in izprazniti vsebino (zrnca).
Your child should take all the food mixture and should then drink enough liquid straight after to wash down all the medicine.
Otrok mora pojesti vso mešanico s hrano in takoj zatem popiti dovolj tekočine, da poplakne vso količino zdravila.
Sodium This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i.e. essentially `sodium-free´.
Natrij To zdravilo vsebuje manj kot 1 mmol natrija (23 mg) na odmerek, torej je praktično »brez natrija«.
It is important to ensure adequate hydration of patients at all times whilst dosing Enzepi.
Pomembno je zagotoviti zadostno hidracijo bolnikov v celotnem obdobju odmerjanja zdravila Enzepi.
The primary efficacy endpoint was the percentage of “responders”, defined as those patients without steatorrhoea (<30% faecal fat content) and without signs and symptoms of malabsorption after one and two weeks of treatment with Enzepi.
Primarni opazovani dogodek učinkovitosti je bil odstotek »odzivnih bolnikov«, opredeljenih kot bolnikov brez steatoreje (< 30 % vsebnosti maščob v blatu) ter brez znakov in simptomov malabsorpcije po enem ali dveh tednih zdravljenja z zdravilom Enzepi.
If you take more Enzepi than you should If you take more Enzepi than you should drink plenty of water and talk to your doctor as soon as possible.
Če ste vzeli večji odmerek zdravila Enzepi, kot bi smeli Če ste vzeli večji odmerek zdravila Enzepi, kot bi smeli, spijte veliko količino vode in se čim prej posvetujte z zdravnikom.
The granules may be administered with a small amount of appropriate acidic food or directly into the mouth.
Bolniku lahko daste zrnca z majhno količino ustrezne kisle hrane ali neposredno v usta.
The contents of the capsule should not be mixed directly into formula or breast-milk as this may diminish efficacy.
Vsebina kapsule se ne sme zmešati neposredno v mlečno formulo ali materino mleko, ker bi to lahko zmanjšalo učinkovitost.
Carefully open the capsule and empty the granules on a small amount of acidic food (see above).
Previdno odprite kapsulo in stresite zrnca na majhno količino kisle hrane (glejte zgoraj).
Adare Pharmaceuticals Srl Via Martin Luther King 13 20060 Pessano Con Bornago ITALY
Adare Pharmaceuticals Srl Via Martin Luther King 13 20060 Pessano Con Bornago ITALIJA
Fertility No human data on the effect of Enzepi on fertility are available.
Plodnost Na voljo ni nobenih podatkov o učinku zdravila Enzepi na plodnost pri ljudeh.
units For the full list of excipients, see section 6.1.
enota Za celoten seznam pomožnih snovi glejte poglavje 6.1.
In clinical trials, 110 children with CF (cystic fibrosis) aged 1 month and older received Enzepi at a dose that ensured stabilization of symptoms.
V kliničnih preskušanjih je 110 otrok s cistično fibrozo, starih 1 mesec in starejših, prejemalo zdravilo Enzepi v odmerku, ki je zagotavljal stabilizacijo simptomov.
The number of responders (patients with less than 30% faecal fat content and without signs and symptoms of malabsorption) at baseline was 10/19 (52.6%), 13/19 (68.4%) after 1 week of treatment (stabilization) and 11/19 (57.9%) after the second week of open-label treatment with Enzepi.
Število odzivnih bolnikov (bolniki z manj kot 30 % vsebnosti maščob v blatu ter brez znakov in simptomov malabsorpcije) je bilo ob izhodišču 10/19 (52,6 %), po 1 tednu zdravljenja (stabilizacija) 13/19 (68,4 %) in po drugem tednu odprtega zdravljenja z zdravilom Enzepi 11/19 (57,9 %).
Enzepi (N=83)
Zdravilo Enzepi (N = 83)
The safety profile of Enzepi in the paediatric population was similar to that observed in adults.
Varnostni profil zdravila Enzepi pri pediatrični populaciji je bil podoben kot pri odraslih.
Crushing, chewing, or mixing capsule contents with food or fluid with a pH greater than 5 or storing the food mixture (see below), can lead to a disruption of the protective gastro-resistant coating.
Drobljenje, žvečenje ali mešanje vsebine kapsule s hrano ali tekočino z vrednostjo pH, višjo od 5, ali shranitev mešanice s hrano (glejte spodaj) lahko vpliva na zaščitno gastrorezistentno oblogo.
You and your doctor should decide if you will take Enzepi or breast-feed.
Vi in vaš zdravnik se morata odločiti, ali boste jemali zdravilo Enzepi ali dojili.
As a risk to newborns/infants cannot be excluded, a decision must be made whether to discontinue breastfeeding or to discontinue/abstain from Enzepi therapy taking into account the benefit of breast-feeding for the child and the benefit of continued Enzepi therapy for the breastfeeding woman.
Ker tveganja za dojenega novorojenca/dojenčka ne moremo izključiti, se je treba odločiti med prenehanjem dojenja in prenehanjem/prekinitvijo zdravljenja z zdravilom Enzepi, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti nadaljevanja zdravljenja z zdravilom Enzepi za doječo mater.
Study EUR-1008-M
Študija EUR-1008-M
The collection was performed in an approved, controlled environment that enabled supervised dietary intake and quantitative stool collection.
Odvzem vzorcev je bil opravljen v odobrenem, nadzorovanem okolju, ki je omogočalo nadzorovan vnos s hrano in odvzem kvantitativnih vzorcev blata.
Infants (below 1 year of age)
Dojenčki (mlajši od 1 leta)
Therefore, no reproductive or developmental toxicity is to be expected.
Zato ni pričakovati škodljivih vplivov na sposobnost razmnoževanja ali razvoj.
Although, no preclinical investigations were carried out with Enzepi there is no evidence for any absorption of this medicinal product.
Z zdravilom Enzepi sicer niso opravili nobenih predkliničnih raziskav, vendar ni dokazov o absorpciji tega zdravila.
The Enzepi soft food mixture should be swallowed immediately without chewing and followed with water or juice to ensure complete ingestion.
Mešanico zdravila Enzepi z mehko hrano je treba takoj pogoltniti brez žvečenja in popiti vodo ali sok, da se zagotovi popolno zaužitje.
Maximum recommended dose
Največji priporočeni odmerek
units
enota
If you notice any of the following seek urgent medical attention straightaway: itching, hives or rash swollen eyes, lips, hands or feet feeling lightheaded or faint trouble breathing or swallowing dizziness, collapse or unconsciousness.
Če opazite katerega od naslednjih neželenih učinkov, nemudoma poiščite nujno zdravniško pomoč: srbenje, koprivnica ali izpuščaj; otečene oči, ustnice, dlani ali stopala; občutek vrtoglavice ali omedlevice; oteženo dihanje ali požiranje; omotica, kolaps ali izguba zavesti.
If you are breast-feeding or plan to breast-feed, or if you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Če dojite ali nameravate dojiti, če ste noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo.
Rarely, a more serious allergic reaction may include a feeling of warmth, dizziness and fainting, trouble breathing; these are symptoms of a severe, potentially life-threatening condition called ‘anaphylactic shock'.
Redko lahko resnejša alergijska reakcija vključuje občutek toplote, omotico in izgubo zavesti ter težave z dihanjem; to so simptomi hudega, potencialno smrtno nevarnega stanja, ki se imenuje »anafilaktični šok«.
For both treatment periods, patients received a dose as close as possible to their stabilized existing pancreatic enzyme product dose on the first day.
V obeh obdobjih zdravljenja so bolniki prvi dan prejeli odmerek, čim bolj podoben ustaljenemu odmerku encimov trebušne slinavke, ki so ga jemali do tedaj.
Enzyme doses expressed as lipase units/kg of body weight per meal must be reduced in older patients because they tend to ingest less fat per kilogram of body weight.
Odmerki encimov, izraženi v enotah lipaze/kg telesne mase na obrok, morajo biti manjši pri starejših bolnikih, ker se nagibajo k zaužitju manj maščob na kilogram telesne mase.
A dose adjustment may be necessary.
Morda bo treba prilagoditi odmerek.
EUR-1008-M was conducted in 34 patients with EPI due to CF, 26 of whom were children, including 8 children aged 7 to 11 years, and 18 adolescents aged 12 to 17 years.
Študija EUR-1008-M je bila opravljena pri 34 bolnikih s pomanjkljivim eksokrinim delovanjem trebušne slinavke zaradi cistične fibroze, od katerih je bilo 26 otrok, vključno z 8 otroki, starimi od 7 do 11 let, ter 18 mladostniki, starimi od 12 do 17 let.
An allergic reaction could include itching, hives or rash.
Alergijska reakcija lahko vključuje srbenje, koprivnico ali izpuščaj.
MARKETING AUTHORISATION NUMBER(S) EU/1/16/1113/001-016
ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET Z ZDRAVILOM EU/1/16/1113/001-016
Do not mix with water, milk, breast-milk, formula, flavoured milk or hot food.
Ne mešajte z vodo, mlekom, materinim mlekom, mlečno formulo, aromatiziranim mlekom ali toplo hrano.
The capsules should be swallowed whole and take them with a drink of water or juice.
Kapsule je treba pogoltniti cele in jih vzeti s kozarcem vode ali soka.
These include lipases for digesting fat, proteases for digesting protein and amylases for digestions carbohydrates.
Vključujejo lipaze za prebavo maščob, proteaze za prebavo beljakovin in amilaze za prebavo ogljikovih hidratov.
Model-based statistics are from a mixed effects linear model using CFA-72h as the response variable, fixed effect factors for treatment, period and treatment sequence, and subject within treatment sequence as a random effect.
Statistični podatki na podlagi modela izhajajo iz linearnega modela mešanih učinkov, kjer je bil koeficient CFA-72h uporabljen kot spremenljivka odziva, zdravljenje, obdobje in zaporedje zdravljenja kot stalni učinki ter preskušanec v zaporedju zdravljenja kot slučajni učinek.
What you need to know before you take Enzepi
Kaj morate vedeti, preden boste vzeli zdravilo Enzepi
Enzepi is designed to release most of the enzymes in vivo at pH greater than 5.5.
Zdravilo Enzepi je zasnovano tako, da in vivo sprosti večino encimov pri vrednosti pH, višji od 5,5.