natgillin/translations-raw huggingface dataset:
In one of the studies of patients with HIV-associated neuropathy, patients who were given Qutenza experienced a 23% reduction in pain scores after 12 weeks compared with an 11% reduction in patients who were given the control.
V eni od študij z bolniki z nevropatijo, povezano z virusom HIV, so bolniki, ki so prejemali zdravilo Qutenza, po 12 tednih zabeležili 23-odstotno zmanjšanje pri točkovanju bolečine v primerjavi z 11-odstotnim zmanjšanjem pri bolnikih, ki so prejemali kontrolno zdravilo.
In patients with painful peripheral diabetic neuropathy, the reduction in pain score from week 2 to after 8 weeks with Qutenza was about 27% compared with 21% for the placebo.
Pri bolnikih z bolečo diabetično periferno nevropatijo je zdravilo Qutenza v dveh do osmih tednih zmanjšalo vrednost pri točkovanju bolečine za 27 % v primerjavi z 21 % pri placebu.
In the second study of patients with HIV-associated neuropathy, although Qutenza reduced pain by 30% it was not shown to be more effective than the control.
V drugi študiji z bolniki z nevropatijo, povezano z virusom HIV, ni bilo dokazano, da je zdravilo Qutenza učinkovitejše od kontrolnega zdravila, čeprav je zmanjšalo bolečino za 30 %.
How has Qutenza been studied?
Kako je bilo zdravilo Qutenza raziskano?
What is Qutenza used for?
Za kaj se zdravilo Qutenza uporablja?
How does Qutenza work?
Kako zdravilo Qutenza deluje?
Qutenza has been compared with control patches containing lower amounts of capsaicin (0.04%) in four main studies involving a total of 1,619 adults with moderate to severe neuropathic pain.
V štirih glavnih študijah, v katere je bilo vključenih 1 619 odraslih z zmerno do hudo nevropatsko bolečino, so zdravilo Qutenza primerjali s kontrolnimi obliži, ki so vsebovali nižje količine kapsaicina (0,04 %).
How is Qutenza used?
Kako se zdravilo Qutenza uporablja?
Qutenza is a cutaneous patch (a patch that delivers a medicine into the skin).
Zdravilo Qutenza je dermalni obliž (obliž, ki dovaja zdravilo na kožo).
What measures are being taken to ensure the safe and effective use of Refixia?
Kateri ukrepi se izvajajo za zagotovitev varne in učinkovite uporabe zdravila Refixia?
The full EPAR for Refixia can be found on the Agency's website: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Celotno evropsko javno poročilo o oceni zdravila (EPAR) za zdravilo Refixia je na voljo na spletni strani agencije: ema.europa.eu/Find medicine/Human medicines/European public assessment reports.
Other information about Refixia
Druge informacije o zdravilu Refixia
Since this could potentially cause problems especially in children below 12 years of age, Refixia is only approved for use in in adults and children from 12 years of age.
Ker lahko to povzroči težave, zlasti pri otrocih, mlajših od 12 let, je zdravilo Refixia odobreno le za uporabo pri odraslih in otrocih od 12. leta starosti naprej.
This is a summary of the European public assessment report (EPAR) for Refixia.
To je povzetek evropskega javnega poročila o oceni zdravila (EPAR) za zdravilo Refixia.
The Agency's Committee for Medicinal Products for Human Use (CHMP) decided that Refixia's benefits are greater than its risks and recommended that it be approved for use in the EU.
Odbor za zdravila za uporabo v humani medicini (CHMP) pri agenciji je zaključil, da so koristi zdravila Refixia večje od z njim povezanih tveganj, in priporočil, da se odobri za uporabo v EU.
It is not intended to provide practical advice on how to use Refixia.
Povzetek ni namenjen zagotavljanju praktičnih nasvetov o njegovi uporabi.
In the second study in 25 children aged below 13 years, all patients were given Refixia as a weekly preventive treatment.
V drugi študiji, ki je vključevala 25 otrok, mlajših od 13 let, so zdravilo Refixia kot tedensko preventivno zdravljenje prejemali vsi bolniki.
What benefits of Refixia have been shown in studies?
Kakšne koristi je zdravilo Refixia izkazalo v študijah?
Hypersensitivity (allergic) reactions are uncommon with Refixia (may affect up to 1 in 100 patients) and may include: swelling, burning and stinging at the injection site, chills, flushing, itchy rash, headache, hives, low blood pressure, lethargy, nausea and vomiting, restlessness, a fast heartbeat, tightness of the chest and wheezing.
Preobčutljivostne (alergijske) reakcije so pri zdravilu Refixia občasne (lahko se pojavijo pri največ 1 bolniku od 100) in lahko vključujejo oteklost, pekoč občutek in zbadanje na mestu injiciranja, mrzlico, vročinske oblive, srbeč izpuščaj, glavobol, koprivnico, nizek krvni tlak, letargijo, navzeo in bruhanje, nemir, hiter srčni utrip, tiščanje v prsnem košu in piskajoče dihanje.
What is Refixia and what is it used for?
Kaj je zdravilo Refixia in za kaj se uporablja?
What are the risks associated with Refixia?
Kakšna tveganja so povezana z zdravilom Refixia?
Patients or their carers may be able to inject Refixia themselves at home once they have been trained appropriately.
Bolniki ali njihovi negovalci lahko po ustreznem usposabljanju zdravilo Refixia injicirajo sami doma.
The company that markets Refixia will conduct a study to investigate the potential effects of PEG accumulation in the choroid plexus of the brain and other organs.
Družba, ki trži zdravilo Refixia, bo izvedla študijo za proučitev potencialnega učinka kopičenja PEG v horoidnem pletežu možganov in v drugih organih.
For further information on how to use this medicine, see the summary of product characteristics (also part of the EPAR).
Za več informacij o uporabi zdravila glejte povzetek glavnih značilnosti zdravila (ki je prav tako del EPAR).
Why is Refixia approved?
Zakaj je bilo zdravilo Refixia odobreno?
In a study involving 74 adults and adolescents aged 13 or above, 29 patients given Refixia as a weekly preventive treatment had around 1 bleeding episode a year, and 15 patients given Refixia for treating bleedings ‘on demand' had around 16 bleeding episodes a year.
V študiji, ki je vključevala 74 odraslih in mladostnikov, starih 13 let ali več, je 29 bolnikov, ki so prejemali zdravilo Refixia kot tedensko preventivno zdravljenje, imelo približno 1 epizodo krvavitve na leto; 15 bolnikov, ki so prejemali zdravilo Refixia za zdravljenje krvavitev po potrebi, pa je imelo približno 16 epizod krvavitev na leto.
Around 86% of bleeding episodes resolved with one injection.
Približno 86 % epizod krvavitev so obvladali z eno injekcijo.
Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Refixia have been included in the summary of product characteristics and the package leaflet.
Priporočila in varnostni ukrepi, ki jih morajo za varno in učinkovito uporabo zdravila Refixia upoštevati zdravstveni delavci in bolniki, so vključeni v povzetek glavnih značilnosti zdravila in navodilo za njegovo uporabo.
Refixia must not be used in patients allergic to hamster proteins.
Zdravilo Refixia se ne sme uporabljati pri bolnikih z alergijo na hrčkove beljakovine.
It replaces the missing factor IX, thereby helping the blood to clot and giving temporary control of bleeding.
Nadomešča manjkajoči faktor IX ter tako pripomore k strjevanju krvi in omogoči začasen nadzor nad krvavitvijo.
The dose and frequency of treatment depend on whether Refixia is used to treat or prevent bleeding, or to reduce bleeding during surgery, the extent and location of the bleeding, and the patient's bodyweight.
Odmerek in pogostnost injiciranja sta odvisna od tega, ali se zdravilo Refixia uporablja za zdravljenje ali preprečevanje krvavitev ali za zmanjšanje krvavitev med kirurškim posegom, od obsega in mesta krvavitve in od bolnikove telesne mase.
87% of bleeding episodes resolved with one injection of Refixia.
87 % epizod krvavitev so obvladali z eno injekcijo zdravila Refixia.
Refixia is available as a powder and a liquid that are mixed together to make a solution for injection into a vein.
Zdravilo Refixia je na voljo v obliki praška in vehikla, ki se zmešata za pripravo raztopine za injiciranje v veno.
It can be used in adults and children from 12 years of age.
Zdravilo Refixia se lahko uporablja pri odraslih in mladostnikih, starih 12 let in več.
Patients had around 1 bleeding episode per year and Refixia was rated excellent or good at treating around 93% of bleeding episodes.
Bolniki so imeli na leto približno 1 epizodo krvavitve na leto, zdravilo Refixia pa je bilo ocenjeno kot odlično ali dobro pri zdravljenju približno 93 % epizod krvavitev.
The active substance in Refixia, nonacog beta pegol, works in the body in the same way as human factor IX.
Zdravilna učinkovina zdravila Refixia, nonakog beta pegol, deluje v telesu enako kot humani faktor IX.
Refixia can only be obtained with a prescription and treatment should be under the supervision of a doctor who has experience in the treatment of haemophilia.
Predpisovanje in izdaja zdravila Refixia je le na recept, zdravljenje z njim pa mora biti pod nadzorom zdravnika z izkušnjami pri zdravljenju hemofilije.
Studies show that Refixia is effective at preventing and treating bleeding episodes in patients with haemophilia B and its safety is comparable to that of other factor IX products.
Študije so pokazale, da zdravilo Refixia učinkovito preprečuje in zdravi epizode krvavitev pri bolnikih s hemofilijo B in da je varnost zdravila primerljiva z varnostjo drugih zdravil s faktorjem IX.
For practical information about using Refixia, patients should read the package leaflet or contact their doctor or pharmacist.
Za praktične informacije o uporabi zdravila Refixia naj bolniki preberejo navodilo za uporabo ali se posvetujejo z zdravnikom ali farmacevtom.
In addition, when bleeding did occur, Refixia was rated excellent or good at treating around 92% of bleeding episodes.
Poleg tega je bilo ob pojavu krvavitve zdravljenje z zdravilom Refixia ocenjeno kot odlično ali dobro pri približno 92 % epizod krvavitev.
Factor IX medicines can also potentially cause problems due to the formation of blood clots in the blood vessels.
Zdravila s faktorjem IX lahko povzročijo težave tudi zaradi nastajanja krvnih strdkov v krvnih žilah.
For more information about treatment with Refixia, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.
Za več informacij o zdravljenju z zdravilom Refixia preberite navodilo za uporabo (ki je prav tako del EPAR) ali se posvetujte z zdravnikom ali farmacevtom.
How is Refixia used?
Kako se zdravilo Refixia uporablja?
However, part of the active substance in Refixia (called PEG) may accumulate in the body, including in a structure in the brain called choroid plexus, following long-term treatment.
Vendar pa se lahko del zdravilne učinkovine zdravila Refixia (imenovan PEG) po dolgotrajnem zdravljenju kopiči v telesu, tudi v strukturi v možganih, imenovani horoidni pletež.
Patients with haemophilia B lack factor IX, a protein needed for normal clotting of the blood, and as a result, they bleed readily.
Bolnikom s hemofilijo B primanjkuje faktorja IX, tj. beljakovine, potrebne za normalno strjevanje krvi, zato hitro zakrvavijo.
Refixia is a medicine used to treat and prevent bleeding in patients with haemophilia B, an inherited bleeding disorder caused by lack of a clotting protein called factor IX.
Zdravilo Refixia se uporablja za zdravljenje in preprečevanje krvavitev pri bolnikih s hemofilijo B, prirojeno motnjo strjevanja krvi zaradi pomanjkanja koagulacijske beljakovine, imenovane faktor IX.
Some patients taking factor IX medicines may develop inhibitors (antibodies) against factor IX, causing the medicine to stop working and resulting in a loss of bleeding control.
Pri bolnikih, ki jemljejo zdravila s faktorjem IX, obstaja tudi tveganje, da se bodo pri njih pojavili zaviralci (protitelesa) faktorja IX, ki bodo izničili njegovo delovanje ter tako povzročili izgubo nadzora nad krvavitvijo.
Refixia contains the active substance nonacog beta pegol.
Zdravilo Refixia vsebuje zdravilno učinkovino nonakog beta pegol.
Refixia has been shown to be effective at both treating bleeding episodes and keeping the number of episodes low.
Zdravilo Refixia se je pokazalo kot učinkovito pri zdravljenju in zmanjševanju števila epizod krvavitev.
How does Refixia work?
Kako zdravilo Refixia deluje?
Date of first authorisation: 16 March 2016
Datum prve odobritve: 16. marec 2016
Produced from the plasma of human donors.
Izdelano iz plazme človeških darovalcev.
• The product is now ready for use.
• Zdravilo je zdaj pripravljeno za uporabo.
• If you are using this medicine for the first time, your doctor will supervise you
• Če zdravilo uporabljate prvič, vas bo nadziral zdravnik.
These include:
Ti ukrepi vključujejo:
The dose and frequency should be based on the individual clinical response.
Odmerek in pogostnost dajanja morata temeljiti na kliničnem odzivu posameznika.
In case of shock, the current medical standards for shock treatment should be observed.
V primeru šoka je treba upoštevati veljavne zdravstvene standarde za zdravljenje šoka.
In this situation, the appropriate dose would be:
V tem primeru bo ustrezni odmerek:
Dissolving your medicines before use
Raztapljanje zdravil pred uporabo
Paediatric population (less than 12 years of age)
Pediatrična populacija (mlajši od 12 let)
EXP: Use within 1 hour of reconstitution.
EXP: Uporabite v 1 uri po rekonstituciji.
Make up the medicine as follows:
Pripravite zdravilo, kot sledi:
Your doctor will recommend an appropriate dose for you.
Zdravnik vam bo priporočil ustrezen odmerek za vas.
How much is given regularly for long-term prevention of bleeds?
Koliko zdravila je treba redno dajati za dolgoročno preprečevanje krvavitev?
Inject your normal dose as you remember and then continue dosing as instructed by your doctor.
Injicirajte si običajni odmerek, ko se spomnite, nato pa nadaljujte z uporabo po navodilih zdravnika.
Do not shake the vial.
Ne pretresajte viale.
The listed warnings and precautions for adults also apply to children (aged 2 to 11 years) and adolescents (aged 12 to 18 years).
Navedena opozorila in previdnostni ukrepi za odrasle veljajo tudi za otroke (stare od 2 do 11 let) in mladostnike (stare od 12 do 18 let).
Your doctor will usually tell you your dose in terms of the number of full vials that supply the dose most suited to you.
Zdravnik vam bo običajno pojasnil vaš odmerek v smislu števila polnih vial, ki so potrebne za odmerek, ki je najprimernejši za vas.
Tell your doctor if you are taking, have recently taken or might take any other medicines.
Obvestite zdravnika, če uporabljate, ste pred kratkim uporabljali ali pa boste morda začeli uporabljati katero koli drugo zdravilo.
Your doctor will check regularly for the development of these antibodies, and especially before an operation.
Zdravnik vas bo redno spremljal, da bo preveril, ali je prišlo do nastanka teh protiteles, še zlasti pred operacijo.
Your doctor will explain to you how much you should use, when you should use it and for how long.
Zdravnik vam bo razložil, koliko zdravila uporabite, kdaj ga morate uporabiti in koliko časa ga boste uporabljali.
Frequency, type and severity of adverse reactions in children are expected to be the same as in adults (see section 5.1).
Predvidevamo, da so pogostnost, vrste in resnost neželenih reakcij pri otrocih enaki kot pri odraslih (glejte poglavje 5.1).
Virus safety
Virusna varnost
Generally the doses for children less than 12 years old are larger than doses for adolescents which should follow those in adults.
Običajno so odmerki pri otrocih, mlajših od 12 let, večji od odmerkov pri mladostnikih, ki naj bi ustrezali tistim za odrasle.
If the solution is cloudy or has any particles, do not use it.
Če je raztopina motna ali vsebuje delce, je ne uporabite.
Coagadex was considered to be good (7%) or excellent (91%) in treating 98% of bleeding episodes.
Zdravilo Coagadex je bilo ocenjeno kot »dobro« (7 %) ali odlično (91 %) pri zdravljenju 98 % epizod krvavitev.
The dose you need will be calculated by your doctor.
Odmerek, ki ga potrebujete, bo izračunal zdravnik.
However, chemical and physical in-use stability has been demonstrated for 1 hour at room temperature (up to 25°C +/-2°C).
Dokazano pa je bilo, da je raztopina za infundiranje kemično in fizikalno stabilna še 1 uro pri sobni temperaturi (do 25 °C +/- 2 °C).
The median dosing interval for all of the nine children was 3 days (range 2 to 8 days).
Mediani interval odmerjanja pri vseh devet otrocih je bil 3 dni (razpon od 2 dni do 8 dni).
The transfer device supplied with the product is sterile and cannot be used more than once.
Pribor za prenos vehikla, ki je priložen izdelku, je sterilen in ga ne smete uporabiti več kot enkrat.
Bio Products Laboratory Limited, Dagger Lane, Elstree, Hertfordshire, WD6 3BX, United Kingdom For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
Bio Products Laboratory Limited, Dagger Lane, Elstree, Hertfordshire, WD6 3BX, Združeno kraljestvo Za vse morebitne nadaljnje informacije o tem zdravilu se lahko obrnete na predstavništvo imetnika dovoljenja za promet z zdravilom:
70 x (90-15) x 0.5 = 2,625 IU.
70 x (90 - 15) x 0,5 = 2,625 i.e.
Do not use this medicine after the expiry date which is stated on the containers after “EXP”.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na vsebnikih poleg oznake »EXP«.
Note: If you have more than one vial to make up your dose, repeat steps 1 through 6 withdrawing the solution in the vial into the same syringe.
Opomba: Če potrebujete za svoj odmerek več kot eno vialo, ponovite korake od 1. do 6. in potegnite raztopino iz viale v isto injekcijsko brizgo.
Both before and after treatment with this medicine, particularly for your first course of treatment, your doctor will probably carry out tests to check the level of factor X in your blood.
Pred in po zdravljenju s tem zdravilom, še posebej v vašem prvem ciklu zdravljenja, bo zdravnik najbrž opravil teste, s katerimi bo preveril raven faktorja X v vaši krvi.
Repeat at intervals of 24 hours until the bleed stops.
Ponavljajte v intervalih 24 ur, dokler krvavitev ne preneha.
After: During the first few days after the operation, your plasma factor X concentration will be checked regularly.
Po: V prvih nekaj dneh po operaciji bodo redno preverjali koncentracijo faktorja X v vaši plazmi.
The mean age was 7.3 (range 2.6 to 11.9) years.
Povprečna starost je bila 7,3 leta (razpon od 2,6 leta do 11,9 leta).
Follow the normal safety practices to administer the medicine.
Upoštevajte običajne varnostne prakse za dajanje zdravila.
• The medicine should be injected when the first sign of bleeding occurs
• Zdravilo je treba injicirati, ko se pojavi prvi znak krvavitve.
Ninety eight (53%) were major bleeding episodes, and 88 (47%) were minor bleeds (one bleed was not assessed).
Osemindevetdeset (53 %) je bilo večjih epizod krvavitev, 88 (47 %) pa je bilo manjših krvavitev (ena krvavitev ni bila ocenjena).
The dose you need will depend on your normal blood level of factor X and will be calculated by your doctor.
Odmerek, ki ga potrebujete, bo odvisen od vaše običajne ravni faktorja X in ga bo izračunal zdravnik.
Each pack contains:
Ena škatla vsebuje:
Six children (66.7%) remained free of bleeds during routine prophylaxis.
Šest otrok (66,7 %) med rutinsko profilakso ni imelo krvavitev.
A total of 184 infusions of Coagadex were given as a preventative measure.
Skupno je bilo 184 infuzij zdravila Coagadex danih kot preventivni ukrep.
<1/1,000) or very rare (<1/10,000) cannot be estimated from the available data.
(≥1/10.000 do <1/1.000) in zelo redkih (<1/10.000) neželenih učinkov ni mogoče oceniti iz razpoložljivih podatkov.
For all surgical procedures, Coagadex was assessed as excellent (no post-operative bleeding, no requirement of blood transfusions, and blood loss was no more than ‘as expected') in controlling blood loss during and after surgery.
Pri vseh kirurških postopkih je bilo zdravilo Coagadex ocenjeno kot odlično (nobenih pooperativnih krvavitev, nobene potrebe po transfuzijah krvi, izguba krvi pa ni bila večja od “pričakovane”) pri nadzoru izgube krvi med in po operaciji.
-if you have a larger or longer bleed than usual and the bleeding does not stop after an injection of Coagadex.
- če imate večjo ali daljšo krvavitev kot običajno in se krvavitev po injekciji zdravila Coagadex ne ustavi.
Although the dose can be estimated using the calculations above, whenever possible appropriate laboratory tests, such as serial factor X assays, should be performed to guide dose adjustments.
Čeprav je odmerek mogoče oceniti s pomočjo zgornjih izračunov, je treba opraviti ustrezne laboratorijske preiskave, kadar je to mogoče, npr. serijske preskuse faktorja X, ki naj usmerjajo prilagoditve odmerkov.
Four bleeding episodes in two subjects were considered treatment failures.
Štiri epizode krvavitev pri dveh bolnikih so veljale za neuspešno zdravljenje.
After reconstitution, the product should be administered by the intravenous route at a suggested rate of 10 mL/min, but no more than 20 mL/min.
Po rekonstituciji je treba zdravilo dati intravensko s predlagano hitrostjo 10 ml/min, vendar ne hitreje od 20 ml/min.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.
Nosečnost, dojenje in plodnost Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden uporabite to zdravilo.
• Each individual bleed should be judged on its own severity
• Vsako posamezno krvavitev je treba oceniti glede stopnje resnosti.
Three children (33.3%), one in the 0-5 years age group and two in the 6-11 years age group had a total of 10 bleeds due to epistaxes, trauma or menorrhagia.
Trije otroci (33,3 %), in sicer eden v starostni skupini 0-5 let in dva v starostni skupini 6-11 let, so imeli skupno 10 krvavitev zaradi epistaks, poškodb ali menoragije.
For safety information with respect to transmissible agents, see section 4.4.
Za varnostne informacije v zvezi s prenosljivimi povzročitelji bolezni glejte poglavje 4.4.
During the dose-adjustment phase, two trough levels were <5 IU/dL but thereafter none were below this threshold.
V obdobju prilagajanja odmerka sta bili dve najnižji ravni <5 i.e./dl, od takrat dalje pa nobena ni zdrsnila pod ta prag.
The third study evaluated the use of Coagadex in routine prophylaxis of bleeding episodes in nine children aged less than 12 years of age.
V tretji študiji so ocenili uporabo zdravila Coagadex pri rutinski profilaksi epizod krvavitev pri devetih otrocih, starih manj kot 12 let.
This should be taken into consideration by patients on a controlled sodium diet.
To je treba upoštevati pri bolnikih, ki so na dieti z nadzorovanim vnosom natrija.
Neither subject had any bleeds during these periods.
V teh obdobjih noben bolnik ni imel krvavitev.
• The injection should be repeated as necessary to stop the bleeding
• Injiciranje je treba po potrebi ponavljati, dokler se krvavitev ne ustavi.
There is a potential for thromboembolism with overdose.
Pri prevelikem odmerjanju obstaja potencial za trombembolijo.
• pain or redness at site of injection
• bolečina ali pordelost na mestu injiciranja
Factor Xa associates with factor Va on a phospholipid surface to form the prothrombinase complex, which activates prothrombin to thrombin in the presence of calcium ions.
Faktor Xa se poveže s faktorjem Va na fosfolipidni površini, kjer tvorita protrombinazni kompleks, ki v prisotnosti kalcijevih ionov aktivira protrombin v trombin.
70 kg x 90 IU/dL/{[2 IU/dL]/[IU/kg]} = 3150 IU.
70 kg x 90 i.e./dl/{[2 i.e./dl]/[i.e./kg]} = 3150 i.e.
Once made up, Coagadex must be used within one hour.
Ko je zdravilo Coagadex pripravljeno, ga morate uporabiti v eni uri.
It is recommended that your blood factor X level is kept above 50 units/dL.
Priporočljivo je, da se vaša raven faktorja X v krvi ohrani nad 50 enot/dl.
Before injection, look at the solution.
Pred injiciranjem si raztopino oglejte.
Eight subjects had severe FX deficiency, the other had moderate deficiency.
Osem bolnikov je imelo resno pomanjkanje FX, eden pa zmerno pomanjkanje FX.