natgillin/translations-raw huggingface dataset:
The recommended doses are 10 mg oxyclozanide per kg bw for cattle and 15 mg oxyclozanide per kg bw for sheep and goats.
Priporočeni odmerki so 10 mg oksiklozanida na kg telesne mase za govedo in 15 mg oksiklozanida na kg telesne mase za ovce in koze.
Two GLP-compliant residue depletion studies in cattle were submitted.
Predloženi sta bili dve študiji o izločanju ostankov pri govedu, skladni z dobro laboratorijsko prakso.
Based on this study, in which residues in all tissues were below the MRL at day 10, and on the data reported in the CVMP EPMAR for oxyclozanide (EMEA/MRL/889/03-FINAL), where total residues were below the MRLs in all tissues at the 14 day timepoint, a withdrawal period of 14 days is retained.
Na podlagi te študije, v kateri so bili 10. dan ostanki v vseh tkivih pod mejno vrednostjo ostankov, in podatki, navedenimi v dokumentu EPMAR odbora CVMP za oksiklozanid (EMEA/MRL/889/03-FINAL), kjer so bili skupni ostanki pod mejnimi vrednostmi ostankov v vseh tkivih po 14 dneh, se določi karenca 14 dni.
• a sheep and goat milk withdrawal period of 7 days.
• karenco za ovčje in kozje mleko 7 dni.
The CVMP was requested to review all available residue depletion data for the veterinary medicinal product Zanil and associated names, and generic products thereof and recommend withdrawal periods for milk, meat and offal derived from treated cattle, sheep and goats.
Odbor CVMP je bil zaprošen, naj pregleda vse razpoložljive podatke o izločanju ostankov za zdravilo Zanil in povezana imena za uporabo v veterinarski medicini ter njegova generična zdravila in priporoči karenco za mleko, meso in organe, pridobljene iz zdravljenega goveda, ovac in koz.
The untreated control animals (one of each sex) were slaughtered at 5 and 21 days.
Nezdravljene kontrolne živali (po ena vsakega spola) so bile zaklane 5. in 21. dan.
The untreated control animals (one of each sex) were slaughtered at 2 and 10 days.
Nezdravljene kontrolne živali (po ena vsakega spola) so bile zaklane 2. in 10. dan.
4.11 Withdrawal period(s) Cattle:
4.11 Karenca Govedo:
For sheep and goats the recommended dose is 15 mg oxyclozanide per kg body weight (equivalent to 4.4 ml of product per 10 kg body weight) with a maximum dose of 0.68 g of oxyclozanide per animal (equivalent to 20 ml of product per animal).
Pri ovcah in kozah je priporočeni odmerek 15 mg oksiklozanida na kg telesne mase (kar ustreza 4,4 ml zdravila na 10 kg telesne mase), največji odmerek pa je 0,68 g oksiklozanida na kg telesne mase (kar ustreza 20 ml zdravila na žival).
For cattle the recommended dose is 10 mg oxyclozanide per kg body weight (equivalent to 3 ml of product per 10 kg body weight) with a maximum dose of 3.5 g of oxyclozanide per animal (equivalent to 105 ml of product per animal).
Za govedo je priporočeni odmerek 10 mg oksiklozanida na kg telesne mase (kar ustreza 3 ml zdravila na 10 kg telesne mase), največji odmerek pa je 3,5 g oksiklozanida na žival (kar ustreza 105 ml zdravila na žival).
In summary, based on the residue depletion study performed with the ‘Nilzan Drench Plus' combination product, considering the residue depletion results presented in the CVMP EPMAR for oxyclozanide (EMEA/MRL/889/03-FINAL), and taking account of the withdrawal period recommended in cattle and the estimated half-life in fat a withdrawal period of 14 days for sheep meat and offal is recommended.
Tako na podlagi študije izločanja ostankov, izvedene s kombiniranim zdravilom „Nilzan Drench Plus“, z upoštevanjem rezultatov izločanja ostankov, predstavljenih v dokumentu EPMAR odbora CVMP za oksiklozanid (EMEA/MRL/889/03-FINAL) in karence, priporočene za govedo, ter ocenjene razpolovne dobe v maščobah, se priporoča karenca 14 dni za ovčje meso in organe.
• a sheep and goat meat and offal withdrawal period of 14 days,
• karenco za meso in organe ovac in koz 14 dni,
Evaluation and conclusions on the benefit-risk balance Having considered the grounds for referral and the available data, the CVMP concluded that the withdrawal periods for milk, meat and offal derived from treated cattle, sheep and goats should be amended as recommended to provide assurance for consumer safety.
Vrednotenje in zaključki o razmerju med tveganji in koristmi Po proučitvi razlogov za napotitev in razpoložljivih podatkov je odbor CVMP menil, da je treba zaradi zagotovitve varnosti potrošnikov karence za mleko, meso in organe, pridobljene iz zdravljene govedi, ovac in koz, spremeniti, kot je predlagano.
Residue depletion data in sheep and goat milk
Podatki o izločanju ostankov za ovčje in kozje mleko
• a cattle meat and offal withdrawal period of 13 days,
• karenco za meso in organe goveda 13 dni,
A GLP-compliant residue depletion study in cattle was submitted, conducted with the veterinary medicinal product ‘Zanil Fluke Drench' at the recommended dose (10 mg oxyclozanide per kg body weight).
Predložena je bila študija o izločanju ostankov veterinarskega zdravila „Zanil Fluke Drench“ pri govedu, ki je bila izvedena v skladu z načeli dobre laboratorijske prakse in s priporočenim odmerkom (10 mg oksiklozanida na kg telesne mase).
Residues levels were also below the MRLs (and limit of quantification) in liver, kidney and muscle on day 21.
Koncentracije ostankov v jetrih, ledvicah in mišicah so bile pod mejno vrednostjo ostanka (in mejo določljivosti) tudi 21. dan.
Residue depletion in cattle meat and offal
Izločanje ostankov za goveje meso in organe
In view of deficiencies noted in the ‘Nilzan Drench Plus' study, namely the fact that the product used was a combination product (oxyclozanide and levamisole) instead of the mono-product Zanil
Glede na pomanjkljivosti, ugotovljene v študiji „Nilzan Drench Plus“, zlasti dejstvo, da je bilo uporabljeno kombinirano zdravilo (oksiklozanid in levamisol) namesto monoterapevtskega zdravila Zanil (oksiklozanid) in da so bili nenormalni rezultati pridobljeni na 21. dan, je za določitev karence primerna uporaba varnostnega faktorja vsaj 30 %.
Residue depletion in sheep meat and offal
Izločanje ostankov za meso in organe ovac
With a view to preserving product availability the CVMP adopted a pragmatic approach, accepting extrapolation of the milk withdrawal period from cattle to sheep and goats , despite the fact that the dose for sheep and goats (15 mg oxyclozanide per kg body weight) is higher than that for bovine animals (10 mg oxyclozanide per kg body weight).
Da bi ohranili razpoložljivost zdravil, je odbor CVMP sprejel pragmatičen pristop in sprejel ekstrapolacijo karence za mleko iz goveda na ovce in koze, kljub dejstvu, da je odmerek za ovce in
Oxyclozanide is a salicylanilide anthelmintic, used for the treatment of fasciolosis in cattle, sheep and goats and also for elimination of gravid tapeworm segments (Moniezia spp).
Zdravilo Zanil in povezana imena za uporabo v veterinarski medicini ter njegova generična zdravila so peroralne suspenzije, ki vsebujejo 34 mg oksiklozanida na ml. Oksiklozanid je salicilanilidni antihelmintik, ki se uporablja za zdravljenje fascioloze pri govedu, ovcah in kozah ter za odstranjevanje odrivkov gravidnih trakulj (Moniezia spp).
No other residue depletion data in sheep meat and offal were provided by the applicants/marketing authorisation holders.
Predlagatelji/imetniki dovoljenj za promet niso predložili drugih podatkov o izločanju ostankov za ovčje meso in organe.
Belgium Merial SAS 29 avenue Tony Garnier 69007 Lyon
Portugalska Merial SAS 29 avenue Tony Garnier 69007 Lyon
The CVMP considered that the withdrawal periods for milk, meat and offal derived from treated cattle, sheep and goats should be amended as proposed to provide assurance for consumer safety.
Ukrepi za obvladovanje ali zmanjšanje tveganja Odbor CVMP je menil, da je treba zaradi zagotovitve varnosti potrošnikov karence za mleko, meso in organe, pridobljene iz zdravljene govedi, ovac in koz, spremeniti, kot je predlagano.
No other residue depletion data in cattle meat and offal were provided by the applicants/marketing authorisation holders.
Predlagatelji/imetniki dovoljenj za promet niso predložili drugih podatkov o izločanju ostankov za goveje meso in organe.
No residue depletion data in goat meat and offal were provided by the applicants/marketing authorisation holders.
Predlagatelji/imetniki dovoljenj za promet niso predložili podatkov o izločanju ostankov za kozje meso in organe.
No other residue depletion data in cattle milk were provided by the applicants/marketing authorisation holders.
Predlagatelji/imetniki dovoljenj za promet niso predložili drugih podatkov o izločanju ostankov za kravje mleko.
No residue depletion data in sheep and goat milk were provided by the applicants/marketing authorisation holders.
Predlagatelji/imetniki dovoljenj za promet niso predložili drugih podatkov o izločanju ostankov za ovčje in kozje mleko.
There is no specific antidote.
Ni specifičnega protistrupa.
6 Adverse reactions (frequency and seriousness)
4.6 Neželeni učinki (pogostost in resnost)
Additional polar metabolites also exist.
Obstajajo tudi njegovi polarni metaboliti.
Date of last renewal: 10 April 2008
Datum zadnjega podaljšanja dovoljenja za promet: 10. april 2008
MARKETING AUTHORISATION NUMBERS EU/2/98/007/001-003
ŠTEVILKA(E) DOVOLJENJ(A) ZA PROMET EU/2/98/007/001-003
Do not use after the expiry date which is stated on the label after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, navedenega na nalepki za oznako »EXP«.
In dogs, the volume of distribution (VDss) is 3.8 l/kg.
Pri psih znaša distribucijski volumen (VDss) 3,8 l/kg.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation 1 April 1998
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum pridobitve dovoljenja za promet: 1. april 1998
MARKETING AUTHORISATION NUMBER EU/2/98/007/001 (5 mg, 30 tablets) EU/2/98/007/002 (20 mg, 30 tablets) EU/2/98/007/003 (80 mg, 30 tablets)
ŠTEVILKA(E) DOVOLJENJ(A) ZA PROMET EU/2/98/007/001 (5 mg, 30 tablet) EU/2/98/007/002 (20 mg, 30 tablet) EU/2/98/007/003 (80 mg, 30 tablet)
Clomipramine and its metabolites are rapidly distributed in the body in mice, rabbits, and rats with high concentrations being achieved in organs and tissues (including the lungs, heart and brain) and low concentrations remaining in the blood.
Klomipramin in njegovi metaboliti se pri miših, kuncih in podganah hitro porazdelijo po organizmu in dosežejo visoke koncentracije v tkivih in organih (vključno s pljuči, srcem in možgani), nizke pa v krvi.
Shelf-life of the veterinary medicinal product as packaged for sale: 4 years
Rok uporabnosti zdravila v pakiranju za prodajo: 4 leta.
Clomicalm should be used under veterinary supervision.
Zdravilo Clomicalm uporabite pod nadzorom veterinarja.
SPECIAL STORAGE CONDITIONS Store in the original container.
POSEBNA NAVODILA ZA SHRANJEVANJE Shranjujte v originalnem vsebniku.
Do not use in case of known hypersensitivity to clomipramine and related tricyclic antidepressants.
Ne uporabite v primerih preobčutljivosti na klomipramin in podobne triciklične antidepresive.
Overdose in human beings causes anticholinergic effects although central nervous and cardiovascular systems may also be affected.
Preveliki odmerki pri ljudeh povzročijo antiholinergične učinke, prizadeta pa sta lahko tudi centralni živčni sistem in kardiovaskularni sistem.
The principle route of excretion in dogs is via the bile (>80%) with the remainder via the urine.
Glavna pot izločanja pri psih je z žolčem (> 80 %), ostalo pa z urinom.
The efficacy and safety of Clomicalm has not been established in dogs weighing less than 1.25 kg or under six months of age.
Ni podatkov o varnosti in učinkovitosti pri uporabi tega zdravila pri psih, lažjih od 1,25 kg in mlajših od 6 mesecev.
Clomicalm may very rarely cause vomiting, changes in appetite, lethargy or an elevation in liver enzymes, which is reversible when the product is discontinued.
Zelo redko lahko zdravilo Clomicalm povzroči bruhanje, spremembe apetita, letargijo ali povišane ravni jetrnih encimov; učinki so reverzibilni, ko se z zdravljenjem preneha.
People with known hypersensitivity to clomipramine should administer the product with caution.
Osebe z znano preobčutljivostjo na klomipramin naj zdravilo dajejo previdno.
CONTENTS BY WEIGHT, BY VOLUME OR BY NUMBER OF DOSES 30 tablets
VSEBINA, IZRAŽENA Z MASO, PROSTORNINO ALI ŠTEVILOM ODMERKOV 30 tablet
In cases showing no improvement after 2 months, treatment with Clomicalm should be ceased.
Če po 2 mesecih zdravljenja ni izboljšanja, prenehajte z dajanjem zdravila Clomicalm.
The principle mechanism of action of clomipramine is potentiation of the effects of 5-HT and noradrenaline in the brain by inhibiting their neuronal reuptake.
Glavni mehanizem delovanja klomipramina je potenciranje učinkov 5HT in noradrenalina v možganih z zaviranjem njune nevronalne ponovne vezave.
In addition, clomipramine has anticholinergic effects by antagonism of cholinergic muscarinic receptors.
Dodatno ima klomipramin antiholinergične učinke zaradi antagonizma holinergičnih muskarinskih receptorjev.
STATEMENT OF THE ACTIVE SUBSTANCE(S) AND OTHER INGREDIENTS
NAVEDBA UČINKOVIN(E) IN DRUGIH SESTAVIN
Clomicalm may be given with or without food.
Zdravilo Clomicalm se lahko daje s hrano ali brez nje.
Do not use in male breeding dogs.
Ne uporabite pri samcih, namenjenih za vzrejo.
Still higher doses (725 mg/kg) produced, in addition, convulsions and death.
Še večji odmerek (725 mg/kg) pa je povzročil krče in pogin.
Clomipramine is well absorbed (>80%) from the gastrointestinal tract in dogs when administered orally but the systemic bioavailability for clomipramine and desmethylclomipramine is 22-26% due to extensive first pass metabolism by the liver.
Klomipramin se pri psih po peroralnem dajanju iz prebavil dobro absorbira (> 80 %), vendar je sistemska biorazpoložljivost klomipramina in desmetilklomipramina zaradi močnega metabolizma prvega prehoda v jetrih le 22-26 %.
Pregnancy: Laboratory studies in mice and rats have shown evidence of embryotoxic effects.
Brejost: Z laboratorijskimi študijami na miših in podganah so bili dokazani embriotoksični učinki.
Laboratory animal studies in mice and rats have shown evidence of embryotoxic effects.
Z laboratorijskimi študijami na miših in podganah so bili dokazani embriotoksični učinki.
Clomipramine is extensively bound to plasma proteins (>97 %) in dogs.
Klomipramin se pri psih dobro veže na plazemske beljakovine (> 97 %).
QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet of Clomicalm contains:
Vsaka tableta zdravila Clomicalm vsebuje:
The administration of Clomicalm is not recommended in combination with, or within 2 weeks of therapy with, monoamine oxidase inhibitors.
Ne priporoča se dajanje zdravila Clomicalm skupaj z ali 2 tedna pred ali po dajanju zaviralcev monoaminooksidaze.
The elimination t1/2 after intravenous administration of clomipramine hydrochloride in dogs was 6.4 hours for clomipramine and 3.6 hours for desmethylclomipramine.
Razpolovni čas izločanja (t1/2) po intravenskem dajanju klomipraminijevega klorida znaša pri psih 6,4 ure za klomipramin in 3,6 ure za desmetilklomipramin.
1 tablet Read the package leaflet before use.
1 tableta Pred uporabo preberite navodilo za uporabo.
One side bears the imprint ‘C/G', the other ‘G/N' and scored on both sides.
Na eni strani je vtisnjena oznaka ‘C/G', na drugi strani oznaka ‘G/N' in zareza na obeh straneh.
As an aid in the treatment of separation-related disorders in dogs manifested by destruction and inappropriate elimination (defaecation and urination) and only in combination with behavioural modification techniques.
Kot pomoč pri zdravljenju specifičnih vedenjskih motenj pri psih, ki se manifestirajo z destrukcijo in nenadzorovanim izločanjem (defekacijo in uriniranjem), skupaj s terapevtskimi tehnikami odprave vedenjskih motenj.
In case of accidental ingestion, seek medical advice immediately and show the product label to the physician.
V primeru nenamernega zaužitja se takoj posvetujte z zdravnikom in mu pokažite navodilo za uporabo ali ovojnino.
PARTICULARS TO APPEAR ON THE OUTER PACKAGE CARDBOARD BOX
PODATKI NA ZUNANJI OVOJNINI Kartonska škatla
The safety of the veterinary medicinal product has not been established in female dogs during pregnancy and lactation.
Varnost zdravila pri psicah v obdobju brejosti in laktacije ni bila ugotovljena.
One side bears the imprint ‘I/I', the other no imprint and scored on both sides.
Na eni strani je vtisnjena oznaka ‘I/I', na drugi strani ni oznake in zareza je na obeh straneh.
Peak plasma levels of clomipramine and desmethylclomipramine are rapidly reached (approx. 1.5-2.5 hours).
Koncentracijo v plazmi dosežeta sorazmerno hitro (1,5 -2,5 ure).
Vomiting may be reduced by co-administration with a small quantity of food.
Bruhanje lahko zmanjšamo tako, da damo zdravilo skupaj z manjšim obrokom hrane.
Because of its potential anticholinergic properties, Clomicalm should also be used with care in dogs with narrow angle glaucoma, reduced gastrointestinal motility or urinary retention.
Zaradi njegovih potencialnih antiholinergičnih lastnosti je potrebna previdna uporaba tudi pri psih, ki imajo glavkom, zmanjšano gastrointestinalno aktivnost ali urinarno retencijo.
One side bears the imprint ‘CG', the other ‘D/V' and a score.
Na eni strani je vtisnjena oznaka ‘CG', na drugi strani oznaka ‘D/V' in zareza.
In clinical trials, a treatment time of 2-3 months with Clomicalm in combination with behavioural modification techniques was sufficient to control the symptoms of separation-related disorders.
S kliničnimi poskusi so dokazali, da je 2-3 mesečno zdravljenje z zdravilom Clomicalm, kombinirano s terapijo vedenjskih motenj, uspešno za odpravo določenih simptomov le-teh. Nekateri primeri zahtevajo daljše zdravljenje.
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports)
- pogosti (pri več kot 1, toda manj kot 10 živalih od 100 zdravljenih živali) - občasni (pri več kot 1, toda manj kot 10 živalih od 1.000 zdravljenih živali) - redki (pri več kot 1, toda manj kot 10 živalih od 10.000 zdravljenih živali)
Both clomipramine and desmethylclomipramine contribute to the effects of Clomicalm: clomipramine is a potent and selective 5-HT reuptake inhibitor while desmethylclomipramine is a potent and selective noradrenaline reuptake inhibitor.
Oba prispevata k delovanju zdravila Clomicalm: klomipramin je učinkovit in selektiven zaviralec ponovne vezave 5-HT, desmetilklomipramin pa učinkovit in selektiven zaviralec ponovne vezave noradrenalina.
Higher doses (500 mg/kg i.e. 250 times the recommended dose) produced emesis, defecation, drooped eyes, trembling and quietness.
Odmerek 500 mg/kg (250-krat večji od priporočenega) je povzročil bruhanje, defekacijo, povešenost oči, tresenje in umirjenost.
Special precautions for use in animals It is recommended that Clomicalm be administered to dogs with cardiovascular dysfunction or epilepsy with caution and only after an assessment of the benefit risk ratio.
Priporočljiva je previdna uporaba pri psih z motnjami v delovanju kardiovaskularnega sistema ali epilepsijo in samo po oceni razmerja korist-tveganje.
The active components in vivo are clomipramine and its major metabolite, desmethylclomipramine.
Glavni učinkovini zdravila Clomicalm in vivo sta klomipramin in njegov glavni metabolit desmetilklomipramin.
Clomicalm may increase the effects of the anti-arrhythmic drug quinidine, anticholinergic agents (e.g. atropine), other CNS active drugs (e.g. barbiturates, benzodiazepines, general anaesthetics, neuroleptics), sympathomimetics (e.g. adrenaline) and coumarine derivatives.
Zdravilo Clomicalm lahko zviša učinke antiaritmika kinidina, antiholinergikov (npr. atropina), drugih zdravil, ki delujejo na centralni živčni sistem (npr. barbituratov, benzodiazepinov, splošnih anestetikov, nevroleptikov), simpatikomimetikov (npr. adrenalina) in kumarinskih derivatov.
Administration of Clomicalm with food causes moderately higher plasma AUC values for clomipramine (25%) and desmethylclomipramine (8%) as compared with administration to fasted dogs.
Pri dajanju zdravila skupaj s hrano so se zvišale plazemske AUC vrednosti klomipramina (25 %) in desmetilklomipramina (8 %), v primerjavi s psi, ki hrane niso dobili.
Clomicalm may be given orally with or without food.
Zdravilo Clomicalm se daje peroralno, lahko s hrano ali brez nje.
Recommendations on the interaction between Clomicalm and other medicaments are derived from studies in species other than dogs.
Podatki o medsebojnem delovanju z drugimi zdravili so pridobljeni iz študij, ki niso bile narejene pri psih, ampak pri drugih vrstah.
One HDPE bottle with child resistant closure and sealing disk, containing 30 tablets and one silica gel desiccant sachet, packed within a cardboard box.
V steklenički je 30 tablet in vrečica s silica gelom.
Clomipramine hydrochloride
klomipraminijev klorid
Repeated administration of Clomicalm causes moderate increases in plasma concentrations, accumulation ratios after oral administration twice daily were 1.2 for clomipramine and 1.6 for desmethylclomipramine, with steady state being reached within 3 days.
Ponavljajoče dajanje zdravila povzroči rahlo povečanje plazemskih koncentracij; akumulacijske vrednosti pri dajanju zdravila dvakrat dnevno so bile 1,2 za klomipramin in 1,6 za desmetilklomipramin.
The maximal plasma concentrations (Cmax) after oral administration of single doses of 2 mg/kg clomipramine hydrochloride were: 240 nmol/l for clomipramine and 48 nmol/l for desmethylclomipramine.
Največja plazemska koncentracija (Cmax) pri peroralnem odmerku 2 mg/kg klomipraminijevega klorida je znašala za klomipramin 240 nmol/l, za desmetilklomipramin pa 48 nmol/l.
Pack size: 30 tablets
Velikost pakiranja: 30 tablet.
5 mg (equivalent to 4.5 mg Clomipramine)
5 mg (kar ustreza 4,5 mg klomipramina)
Hepato-biliary disease has been reported, especially with pre-existing conditions, and concurrent administrations of drugs metabolized via the hepatic system.
Poročali so o jeternožolčnih boleznih, predvsem, če so že prej obstajali pogoji zanje in pri sočasni uporabi zdravil, ki se presnavljajo preko jetrnega sistema.
At steady state, the ratio of plasma clomipramine to desmethylclomipramine concentrations is approximately 3:1.
Pri ustaljenih vrednostih je bilo razmerje med plazemsko koncentracijo klomipramina in desmetilklomipramina 3:1.
If you notice any side effects, even those not already listed in this package leaflet or you think that the medicine has not worked, please inform your veterinary surgeon.
- zelo redki (pri manj kot 1 živali od 10.000 zdravljenih živali, vključno s posameznimi primeri) Če opazite kakršne koli stranske učinke, tudi tiste, ki niso navedeni v tem navodilu za uporabo, ali mislite, da zdravilo ni delovalo, obvestite svojega veterinarja.
Simultaneous administration with cimetidine may lead to increased plasma levels of clomipramine.
Sočasno dajanje cimetidina povzroči dvig plazemske koncentracije klomipramina.
1-2 mg clomipramine/kg bw twice daily.
1-2 mg klomipramina/kg telesne mase dvakrat dnevno.
At overdose with 20 mg/kg Clomicalm (5 times the maximum therapeutic dose), bradycardia and arrhythmias (atrioventricular node block and ventricular escape beats) were observed approximately 12 hours after dosing.
Pri odmerku 20 mg/kg (5-krat večji od priporočenega) se je pri psih čez 12 ur pojavila bradikardija in aritmija (atrioventrikularni blok in izostali ventrikularni utrip).
It therefore possesses the properties of a serotonin re-uptake inhibitor and a tricyclic antidepressant.
Je triciklični antidepresiv in zaviralec ponovne vezave serotonina.
ROUTE(S) OF ADMINISTRATION For oral use.
POT(I) UPORABE ZDRAVILA Peroralna uporaba.
B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE Veterinary medicinal product subject to prescription.
B POGOJI TER OMEJITVE GLEDE OSKRBE IN UPORABE Rp-Vet.
80 mg (equivalent to 71.7 mg Clomipramine)
80 mg (kar ustreza 71,7 mg klomipramina)