natgillin/translations-raw huggingface dataset:
Absorption of omeprazole is rapid, with peak plasma levels occurring approximately 1-2 hours after dose.
Absorpcija omeprazola je hitra, največjo koncentracijo v plazmi pa doseže približno 1 do 2 uri po odmerku.
In order to immediately achieve a similar reduction of intragastric acidity as after repeated dosing with 20 mg orally, a first dose of 40 mg intravenously is recommended.
Da bi takoj dosegli podobno zmanjšanje želodčne kislosti, kot je doseženo po večkratnem odmerjanju 20 mg peroralno, je priporočeni prvi odmerek 40 mg intravensko.
Pharmacodynamic effects All pharmacodynamic effects observed can be explained by the effect of omeprazole on acid secretion.
Farmakodinamični učinki Vse opažene farmakodinamične učinke je mogoče pojasniti z učinkom omeprazola na izločanje kisline.
Symptomatic treatment of heartburn and acid regurgitation in gastro-esophageal reflux disease: The treatment time is 2-4 weeks.
Simptomatsko zdravljenje zgage in regurgitacije kisline pri gastroezofagealni refluksni bolezni: Trajanje zdravljenja je od 2 do 4 tedne.
Intravenous doses of up to 270 mg on a single day and up to 650 mg over a three-day period have been given in clinical trials without any dose-related adverse reactions.
V kliničnih preskušanjih so bili uporabljeni intravenski odmerki do 270 mg na posamezen dan in do 650 mg v tridnevnem obdobju, ne da bi se pojavili z odmerkom povezani neželeni učinki.
However, dose adjustment should be considered in patients with severe hepatic impairment and if long-term treatment is indicated.
Pride pa prilagoditev v poštev pri bolnikih s hudo okvaro jeter ali če je indicirano dolgotrajno zdravljenje.
It belongs to a group of medicines called ‘proton pump inhibitors'.
Spada v skupino zdravil, imenovanih "zaviralci protonske črpalke".
In another study it was shown that administering clopidogrel and omeprazole at different times did not prevent their interaction that is likely to be driven by the inhibitory effect of omeprazole on CYP2C19.
Druga študija je pokazala, da uporaba klopidogrela in omeprazola ob različnem času ne prepreči njunega medsebojnega delovanja, ki je verjetno posledica zavrtja CYP2C19 z omeprazolom.
These changes are the result of sustained hypergastrinaemia secondary to acid inhibition.
Te spremembe so posledica trajne hipergastrinemije zaradi zavrtja kisline.
Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN) Musculoskeletal and connective tissue disorders Rare:
multiformni eritem, Stevens-Johnsonov sindrom, toksična epidermalna nekroliza (TEN) Bolezni mišično-skeletnega sistema in vezivnega tkiva Redki:
This results in an immediate decrease in intragastric acidity and a mean decrease over 24 hours of approximately 90% for both iv injection and iv infusion.
To povzroči takojšnje zmanjšanje želodčne kislosti in povprečno 90 % 24-urno zmanjšanje tako po intravenski injekciji kot intravenski infuziji.
It might be necessary to take the tablets for 2-3 consecutive days to achieve improvement of symptoms.
Za izboljšanje simptomov je lahko potrebno jemanje teh tablet 2 ali 3 dni zapored.
In a non-controlled study in children (1 to 16 years of age) with severe reflux esophagitis, omeprazole at doses of 0.7 to 1.4 mg/kg improved esophagitis level in 90% of the cases and significantly reduced reflux symptoms.
V nekontrolirani študiji pri otrocih (starih od 1 do 16 let) s hudim refluksnim ezofagitisom je omeprazol v odmerkih od 0,7 do 1,4 mg/kg izboljšal stopnjo ezofagitisa v 90 % primerov ter je bistveno zmanjšal simptome refluksa.
• Digoxin (used to treat heart problems)
• digoksin (uporablja se za zdravljenje težav s srcem).
In case of therapy failure, the dose can be increased to 40 mg.
Če zdravljenje ni uspešno, je mogoče odmerek povečati na 40 mg.
This medicinal product is authorised in the Member States of the EEA under the following names: [See Annex I - To be completed nationally]
To zdravilo je odobreno v državah članicah EGP pod naslednjimi imeni: [Glejte Dodatek I - izpolni država članica]
In children, the symptoms of the condition can include the return of stomach contents into the mouth (regurgitation), being sick (vomiting) and poor weight gain.
Pri otrocih so lahko med simptomi te bolezni vračanje želodčne vsebine v usta (regurgitacija), bruhanje in slabo pridobivanje telesne mase.
These changes are a physiological consequence of pronounced inhibition of acid secretion, are benign and appear to be reversible.
Te spremembe so fiziološka posledica izrazito zavrtega izločanja želodčne kisline, so benigne in po vsem sodeč reverzibilne.
Concomitant treatment with omeprazole (20 mg daily) and digoxin in healthy subjects increased the bioavailability of digoxin by 10%.
Sočasno zdravljenje z omeprazolom (20 mg na dan) in digoksinom je pri zdravih preiskovancih povečalo biološko uporabnost digoksina za 10 %.
No other solvent should be used.
Drugega vehikla se ne sme uporabljati.
They could, however, be considered in cases where known hypersensitivity precludes use of any triple combination.
Vendar lahko pridejo v poštev, če zaradi znane preobčutljivosti ni mogoče uporabiti nobene tritirne kombinacije.
When doses exceed 60 mg daily, the dose should be divided and given twice daily.
Če odmerki presežejo 60 mg na dan, je treba odmerek razdeliti in ga dati dvakrat na dan.
WHAT LOSEC IS AND WHAT IT IS USED FOR
KAJ JE ZDRAVILO LOSEC IN ZA KAJ GA UPORABLJAMO
Concomitant administration of omeprazole with saquinavir/ritonavir resulted in increased plasma levels up to approximately 70% for saquinavir associated with good tolerability in HIV-infected patients.
Uporaba omeprazola hkrati s sakvinavirjem/ritonavirjem je povzročila povečanje koncentracije sakvinavirja v plazmi do približno 70 %, a bolniki, okuženi s HIV, so to dobro prenašali.
280 capsules
280 kapsul
If you forget to take Losec
Če ste pozabili vzeti zdravilo Losec
Taste disturbance
motnje okušanja
No tachyphylaxis has been observed during treatment with omeprazole.
Med zdravljenjem z omeprazolom niso opazili tahifilaksije.
• Severe kidney problems (interstitial nephritis).
• hude težave z ledvicami (intersticijski nefritis)
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Če vam je zdravnik povedal, da imate intoleranco za nekatere sladkorje, se z njim posvetujte, preden začnete jemati to zdravilo.
Powder and solvent for solution for injection (Powder for injection; and Solvent for injection) pH 8.8 to 9.2
FARMACEVTSKA OBLIKA prašek in vehikel za raztopino za injiciranje (prašek in vehikel za injekcije) pH od 8,8 do 9,2
Omeprazole is 97% plasma protein bound.
Omeprazol je 97 % vezan na beljakovine v plazmi.
Your doctor will tell you how many capsules to take and how long to take them for.
Zdravnik vam bo povedal, koliko kapsul morate vzeti in koliko časa jih morate jemati.
Powder for solution for infusion (Powder for infusion) pH interval in glucose is approximately 8.9-9.5 and in sodium chloride 0.9%, 9.3-10.3
FARMACEVTSKA OBLIKA prašek za raztopino za infundiranje (prašek za infuzijo) Razpon pH v glukozi je približno od 8,9 do 9,5 in v 0,9 % natrijevem kloridu od 9,3 do 10,3.
If affected, patients should not drive or operate machinery.
Bolniki, ki se jim to zgodi, ne smejo voziti ali upravljati s stroji.
The dispersion should always be stirred just before drinking and rinsed down with half a glass of water.
Disperzijo je treba tik pred pitjem vedno premešati in jo poplakniti s pol kozarca vode.
These micro-pellets contain the active substance omeprazole and are enteric coated which protects them from being broken down during passage through the stomach.
Te mikrokroglice vsebujejo zdravilno učinkovino omeprazol in so gastrorezistentne, tako da so zaščitene pred razgradnjo med prehodom skozi želodec.
However, due to low affinity to CYP3A4, omeprazole has no potential to inhibit the metabolism of other CYP3A4 substrates.
Toda zaradi majhne afinitete za CYP3A4, omeprazol nima potenciala za zavrtje presnove drugih substratov CYP3A4.
• Liver problems, including jaundice which can cause yellow skin, dark urine, and tiredness.
• težave z jetri, vključno z zlatenico, ki lahko povzroči porumenelost kože, temen urin in utrujenost
Agitation, confusion, depression
agitiranost, zmedenost, depresija
There are limited long term safety data from 46 children who received maintenance therapy of omeprazole during a clinical study for severe erosive esophagitis for up to 749 days.
Na voljo so nezadostni podatki o dolgoročni varnosti, zbrani pri 46 otrocih, ki so v klinični študiji zaradi hudega erozivnega ezofagitisa dobivali vzdrževalno zdravljenje z omeprazolom do 749 dni.
Therapeutic drug monitoring of digoxin should be then be reinforced.
V takšnih okoliščinah je treba intenzivneje terapevtsko kontrolirati digoksin.
Add approximately 5 ml of the solvent to the vial with freeze-dried omeprazole.
Dodajte približno 5 ml vehikla v vialo z liofiliziranim omeprazolom.
H. pylori is a major factor in the development of gastritis.
H. pylori je eden glavnih dejavnikov za nastanek gastritisa.
• You are aged over 55 years with new or recently changed symptoms.
• Če ste starejši od 55 let in se vam pojavijo novi simptomi ali se vam simptomi spremenijo.
- To make sure that you have drunk all of the medicine, rinse the glass very well with half a glass of water and drink it.
- Da boste popili zares vse zdravilo, kozarec nato zelo dobro splaknite s pol kozarca vode in to vodo popijte.
• Yellow skin, dark urine and tiredness which can be symptoms of liver problems.
• Porumenelost kože, temen urin in utrujenost; to so lahko simptomi težav z jetri.
Hypersensitivity to omeprazole, substituted benzimidazoles or to any of the excipients.
Preobčutljivost za omeprazol, substituirane benzimidazole ali katerokoli pomožno snov.
PHARMACEUTICAL FORM AND CONTENTS 1x40 mg
FARMACEVTSKA OBLIKA IN VSEBINA 1 x 40 mg
HDPE bottle: with a tight fitting polypropylene screw-cap equipped with a desiccant capsule.
Plastenka iz HDPE: z natančno prilegajočo se polipropilensko navojno zaporko, opremljena s kapsulo s sušilom.
Bioequivalence between Losec capsules and Losec gastro-resistant tablets, based on both area under the omeprazole plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) of omeprazole, has been demonstrated for all doses, 10 mg, 20 mg and 40 mg.
Bioekvivalentnost kapsul Losec in gastrorezistentnih tablet Losec je bila na podlagi površine pod krivuljo koncentracije omeprazola v plazmi po času (AUC) in največje koncentracije omeprazola v plazmi (Cmax) dokazana za vse odmerke: 10 mg, 20 mg in 40 mg.
If the combination of atazanavir with a proton pump inhibitor is judged unavoidable, close clinical monitoring (e.g virus load) is recommended in combination with an increase in the dose of atazanavir to 400 mg with 100 mg of ritonavir; omeprazole 20 mg should not be exceeded.
Če se sočasni uporabi atazanavirja in zaviralca protonske črpalke ni mogoče izogniti, sta priporočljiva natančen klinični nadzor (npr. virusnega bremena) ter povečanje odmerka atazanavirja na 400 mg s 100 mg ritonavirja; odmerek omeprazola ne sme preseči 20 mg.
It is recommended to take Losec capsules in the morning, preferably without food, swallowed whole with half a glass of water.
Kapsule Losec je priporočljivo vzeti zjutraj, po možnosti na prazen želodec (brez hrane), in jih zaužiti cele s pol kozarca vode.
Losec solution for injection must be given only as an intravenous injection and it must not be added to infusion solutions.
Raztopino za injiciranje Losec se sme uporabiti le v intravenski injekciji in se je ne sme dodajati raztopinam za infundiranje.
What to do if you have trouble swallowing the tablets
Kaj storiti, če težko zaužijete tablete
If you are not sure, talk to your doctor, nurse or pharmacist before you are given this medicine.
Če ste negotovi, se posvetujte z zdravnikom, medicinsko sestro ali farmacevtom, preden dobite to zdravilo.
This increase is dose-dependent and results in a non-linear dose-AUC relationship after repeated administration.
Povečanje je odvisno od odmerka in povzroči nelinearno povezanost med odmerkom in AUC po večkratni uporabi.
INFORMATION IN BRAILLE Hospital pack: Justification for not including Braille accepted
PODATKI V BRAILLOVI PISAVI Bolnišnično pakiranje: Sprejeta je utemeljitev, zakaj niso vključeni podatki v Braillovi pisavi.
Rotate and shake the vial to ensure all the freeze-dried omeprazole has dissolved.
Vrtite in pretresajte vialo, da boste zagotovili raztopitev liofiliziranega omeprazola.
These findings have no implications for the posology of omeprazole.
Ti izsledki ne vplivajo na odmerjanje omeprazola.
However, you still need to take Losec carefully to get the best results from it.
Kljub temu ga morate zdravilo Losec jemati pazljivo in skrbno, da vam bo kar najbolje koristilo.
• Changes in blood count including agranulocytosis (lack of white blood cells)
• spremembe števila krvnih celic, vključno z agranulocitozo (pomanjkanjem belih krvnih celic)
• Allergic reactions, sometimes very severe, including swelling of the lips, tongue and throat, fever,
• alergijske reakcije, ki so včasih zelo hude, vključno z otekanjem ustnic, jezika in žrela, zvišana telesna temperatura, piskajoče dihanje
Paediatric patients There is limited experience with Losec for intravenous use in children.
Pediatrični bolniki Z intravensko uporabo zdravila Losec je pri otrocih malo izkušenj.
Impaired hepatic function In patients with impaired hepatic function a daily dose of 10-20 mg may be sufficient (see section 5.2).
Bolnikom z okvarjenim delovanjem jeter lahko zadošča dnevni odmerek od 10 do 20 mg (glejte poglavje 5.2).
• Severe liver problems leading to liver failure and inflammation of the brain.
• hude težave z jetri, ki povzročijo odpoved jeter in vnetje možganov
Malaise, peripheral oedema
splošno slabo počutje, periferni edemi
• Long-term management of patients with healed reflux esophagitis
• dolgotrajno vodenje bolnikov z ozdravljenim refluksnim ezofagitisom
This is where acid from the stomach escapes into the gullet (the tube which connects your throat to your stomach) causing pain, inflammation and heartburn.
Gre za bolezen, pri kateri kislina iz želodca uhaja v požiralnik (cev, ki povezuje žrelo z želodcem); to povzroča bolečine, vnetje in zgago.
However caution should be exercised when omeprazole is given at high doses in elderly patients.
Previdnost pa je potrebnav primeru uporabe velikih odmerkov omeprazola pri starejših bolnikih.
The solution for infusion is to be administrered in an intravenous infusion for 20-30 minutes.
Raztopino za infundiranje je treba dati v intravenski infuziji, ki traja od 20 do 30 minut.
Alternatively patients can suck the capsule and swallow the pellets with half a glass of water.
Druga možnost je, da bolnik vsebino kapsule posesa in kroglice pogoltne s pol kozarca vode.
As a consequence of high affinity of omeprazole to CYP2C19, there is a potential for competitive inhibition and metabolic drug-drug interactions with other substrates for CYP2C19.
Zaradi velike afinitete omeprazola za CYP2C19 obstaja možnost kompetitivne inhibicije in presnovnega medsebojnega delovanja z drugimi substrati CYP2C19.
Chemical and physical in-use stability has been demonstrated for 12 hours at 25°C after reconstitution with sodium chloride 9 mg/ml (0.9%) solution for infusion and for 6 hours at 25°C after reconstitution with glucose 50 mg/ml (5%) solution for infusion.
Kemična in fizikalna stabilnost med uporabo sta dokazani za 12 ur pri temperaturi 25 °C, če je zdravilo pripravljeno z 0,9 % (9 mg/ml) raztopino natrijevega klorida za infundiranje, in za 6 ur pri temperaturi 25 °C, če je pripravljeno s 5 % (50 mg/ml) raztopino glukoze za infundiranje.
I. Powder for injection Each vial contains sodium hydroxide.
I. prašek za injekcijo Vsaka viala vsebuje natrijev hidroksid.
Losec can also be used to stop ulcers from forming if you are taking NSAIDs.
Zdravilo Losec se lahko uporablja tudi za preprečitev nastanka razjed, če jemljete NSAID.
Children over 1 year of age and ≥ 10 kg Treatment of reflux esophagitis
Otroci, starejši od 1 leta in s telesno maso ≥ 10 kg Zdravljenje refluksnega ezofagitisa
Patients with impaired hepatic function should be advised by a doctor before taking Losec (see section 5.2).
Bolniki z okvarjenim delovanjem jeter se morajo pred uporabo zdravila Losec posvetovati z zdravnikom (glejte poglavje 5.2).
Total plasma clearance is about 30-40 l/h after a single dose.
Celotni plazemski očistek po enkratnem odmerku je približno 30 do 40 l/h.
• ‘Gastro-esophageal reflux disease' (GERD).
• Gastroezofagealne refluksne bolezni (GERB).
• An infection called “thrush” which can affect the gut and is caused by a fungus.
• okužba, imenovana "gobice", ki lahko prizadene črevo in jo povzročajo glivice
For instructions on reconstitution of the product before administration, see section 6.6.
Za navodila o pripravi (rekonstituciji) zdravila pred uporabo glejte poglavje 6.6.
Solution for infusion reconstituted with glucose 50 mg/ml (5%) should be used within 6 hours after preparation.
Raztopino za infundiranje, pripravljeno s 5 % (50 mg/ml) glukozo, je treba uporabiti v 6 urah po pripravi.
An interaction is observed between clopidogrel and omeprazole (see section 4.5).
Opazili so medsebojno delovanje med klopidogrelom in omeprazolom (glejte poglavje 4.5).
Reflux is the backflow of acid from the stomach into the gullet “foodpipe”, which may become inflamed and painful.
Refluks pomeni vračanje kisline iz želodca v požiralnik, ki se zaradi tega lahko vname in boli.
• Cilostazol (used to treat intermittent claudication)
• cilostazol (uporablja se za zdravljenje intermitentne klavdikacije).
The metabolism of omeprazole in patients with liver dysfunction is impaired, resulting in an increased AUC.
Pri bolnikih z motenim delovanjem jeter je presnova omeprazola okvarjena in posledica je povečanje AUC.
Use only clear, colourless or pale yellowish-brown solutions.
Uporabite le bistre, brezbarvne ali bledo rumenkastorjave raztopine.
The tablets must not be chewed or crushed.
Tablet se ne sme zgristi ali zdrobiti.
Connect the other needle-end from the vial with freeze-dried omeprazole.
Priključite drugi konec igle iz viale z liofiliziranim omeprazolom.
• Disturbed sleep (insomnia).
• motnje spanja (nespečnost)
A randomised, double blind clinical study (Héliot study) concluded that omeprazole in combination with two antibiotics (amoxicillin and clarithromycin), was safe and effective in the treatment of H. pylori infection in children age 4 years old and above with gastritis: H. pylori eradication rate: 74.2% (23/31 patients) with omeprazole + amoxicillin + clarithromycin versus 9.4% (3/32 patients) with amoxicillin + clarithromycin.
Randomizirana, dvojno slepa študija (Héliotova študija) je pokazala, da je omeprazol v kombinaciji z dvema antibiotikoma (amoksicilinom in klaritromicinom) varna in učinkovita terapija okužbe s H. pylori pri otrocih z gastritisom, starih 4 leta ali več: delež odprave H. pylori: 74,2 % (23/31 bolnikov) s kombinacijo omeprazol + amoksicilin + klaritromicin in 9,4 % (3/32 bolnikov) s kombinacijo amoksicilin + klaritromicin.
Agranulocytosis, pancytopenia Immune system disorders Rare:
agranulocitoza, pancitopenija Bolezni imunskega sistema Redki:
Other effects related to acid inhibition
Drugi učinki, povezani z zavrtjem kisline
28 tablets (10 mg only)
28 tablet (samo 10 mg)
Draw the omeprazole solution back into the syringe.
Potegnite raztopino omeprazola nazaj v brizgo.
Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
Bolniki z redkimi prirojenimi motnjami, kot so intoleranca za fruktozo, malabsorbcija glukoze-galaktoze ali insuficienca saharaze-izomaltaze, ne smejo jemati tega zdravila.
Losec is not likely to affect the ability to drive or use machines.
Ni verjetno, da bi zdravilo Losec vplivalo na sposobnost vožnje in upravljanja s stroji.
It is rapidly acting and provides control through reversible inhibition of gastric acid secretion with once daily dosing.
Deluje hitro in omogoča nadzor z reverzibilnim zavrtjem izločanja želodčne kisline z odmerjanjem enkrat na dan.
In each regimen, if the patient is still H. pylori positive, therapy may be repeated.
Če je bolnik še vedno H. pylori-pozitiven, je treba zdravljenje pri vsaki od teh shem ponoviti.
If you have any further questions, ask your doctor, nurse or pharmacist.
- Če imate dodatna vprašanja, se posvetujte z zdravnikom, medicinsko sestro ali farmacevtom.
Important information about some of the ingredients of Losec Losec capsules contain lactose.
Pomembne informacije o nekaterih sestavinah zdravila Losec Kapsule Losec vsebujejo laktozo.
• Shelf life after reconstitution:
• Rok uporabnosti po pripravi:
Omeprazole, given in doses of 40 mg to healthy subjects in a cross-over study, increased Cmax and AUC for cilostazol by 18% and 26% respectively, and one of its active metabolites by 29% and 69% respectively.
V navzkrižni študiji je omeprazol, uporabljen v 40-mg odmerkih pri zdravih preiskovancih, povečal Cmax cilostazola za 18 % in njegovo AUC za 26 % ter Cmax enega od njegovih aktivnih presnovkov za 29 % in AUC tega presnovka za 69 %.
• Feeling agitated, confused or depressed.
• vznemirjenost, zmedenost ali potrtost
If you notice any of the following rare but serious side effects, stop taking Losec and contact a doctor immediately:
Če opazite katerega od naslednjih redkih, toda resnih neželenih učinkov, nehajte jemati zdravilo Losec in se nemudoma posvetujte z zdravnikom:
This effect on the final step of the gastric acid formation process is dose-dependent and provides for highly effective inhibition of both basal acid secretion and stimulated acid secretion, irrespective of stimulus.
Ta učinek na zadnjo stopnjo nastajanja želodčne kisline je odvisen od odmerka in omogoča izredno učinkovito zavrtje bazalnega in stimuliranega izločanja kisline, ne glede na dražljaj.
This could be ‘Stevens-Johnson syndrome' or ‘toxic epidermal necrolysis'.
To je lahko t. i. Stevens-Johnsonov sindrom ali toksična epidermalna nekroliza.
Losec gastro-resistant tablets are indicated for:
Gastrorezistentne tablete Losec so indicirane za:
Hospital pack: Justification for not including Braille accepted
Bolnišnično pakiranje: Sprejeta je utemeljitev, zakaj niso vključeni podatki v Braillovi pisavi.
If you are not sure, talk to your doctor or pharmacist before taking Losec.
Če ste negotovi, se posvetujte z zdravnikom ali farmacevtom, preden vzamete zdravilo Losec.
Losec 40 mg powder for solution for infusion (powder for infusion) comes in a vial.
Losec 40 mg prašek za raztopino za infundiranje (prašek za infuzijo) je na voljo v viali.
When starting or ending treatment with omeprazole, the potential for interactions with drugs metabolised through CYP2C19 should be considered.
Na začetku in na koncu zdravljenja z omeprazolom je treba upoštevati možnost medsebojnega delovanja z zdravili, ki se presnavljajo s CYP2C19.
The co-administration of omeprazole (20 mg once daily) with atazanavir 400 mg/ritonavir 100 mg to healthy volunteers resulted in a decrease of approximately 30% in the atazanavir exposure as compared to atazanavir 300 mg/ritonavir 100 mg once daily.
Uporaba omeprazola (20 mg enkrat na dan) hkrati s 400 mg atazanavirja/100 mg ritonavirja je pri zdravih prostovoljcih zmanjšala izpostavljenost atazanavirju za približno 30 % v primerjavi s 300 mg atazanavirja/100 mg ritonavirja enkrat na dan.
In patients with Zollinger-Ellison Syndrome the recommended initial dose of Losec given intravenously is 60 mg daily.
Pri bolnikih z Zollinger-Ellisonovim sindromom je priporočeni začetni odmerek intravenskega zdravila Losec 60 mg na dan.
Decreased gastric acidity due to any means including proton pump inhibitors, increases gastric counts of bacteria normally present in the gastrointestinal tract.
Zmanjšana želodčna kislost zaradi kakršnegakoli vzroka, vključno z zaviralci protonske črpalke, v želodcu poveča število bakterij, ki so običajno prisotne v prebavilih.
Elderly (> 65 years old) Dose adjustment is not needed in the elderly (see section 5.2).
Starejši (> 65 let) Starejšim bolnikom odmerka ni treba prilagoditi (glejte poglavje 5.2).