natgillin/translations-raw huggingface dataset:
If you have an erection which lasts for more than 4 hours, you should contact a doctor immediately.
Če imate erekcijo, ki traja dlje kot 4 ure, se morate nemudoma posvetovati z zdravnikom.
Tip the tablet onto your hand and place it on the tongue.
Tableto stresite na dlan in jo položite na jezik.
In cases of overdose, standard supportive measures should be adopted as required.
Pri prevelikem odmerjanju je treba uvesti standardno podporno zdravljenje.
Do not take Vizarsin: - If you are allergic to sildenafil or any of the other ingredients of this medicine (listed in section
Ne jemljite zdravila Vizarsin - Če ste alergični na sildenafil ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
If you are taking medicines known as protease inhibitors, such as for the treatment of HIV, your doctor may start you on the lowest dose (25 mg) of Vizarsin.
Če jemljete zdravila, ki so znana kot zaviralci proteaz (npr. zdravila za zdravljenje okužbe s HIV), vam bo zdravnik na začetku morda predpisal najmanjši odmerek zdravila Vizarsin, tj. 25 mg.
If you feel that the effect of Vizarsin is too strong or too weak, talk to your doctor or pharmacist.
Če menite, da je učinek zdravila Vizarsin premočan ali prešibak, se posvetujte z zdravnikom ali s farmacevtom.
- If you experience sudden decrease or loss of vision, stop taking Vizarsin and contact your doctor immediately.
- če doživite nenadno poslabšanje ali izgubo vida, prenehajte jemati zdravilo Vizarsin in se takoj obrnite na svojega zdravnika.
When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%.
Če se sildenafil jemlje s hrano, se stopnja absorpcije zmanjša s srednjo zakasnitvijo tmax 60 minut in s srednjim zmanjšanjem Cmax za 29 %.
Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment.
Pri takšnih bolnikih smemo sildenafil zato uporabiti le potem, ko smo skrbno pretehtali koristi in tveganja.
In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo.
V nadzorovani kliničnih preizkušanjih je bil delež prekinitev zaradi sildenafila majhen in primerljiv s placebom.
Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects.
Zato je za doseganje želenih farmakoloških učinkov sildenafila potrebna spolna stimulacija.
At maximum recommended doses, there is an 80-fold selectivity over PDE1, and over 700-fold over PDE2, 3, 4, 7, 8, 9, 10 and 11.
V največjih priporočenih odmerkih je selektivnost 80-kratna v primerjavi s PDE1 in prek 700-kratna v primerjavi s PDE2, 3, 4, 7, 8, 9, 10 in 11.
Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg.
Glede na učinkovitost in prenašanje je odmerek mogoče povečati na 100 mg ali zmanjšati na 25 mg.
If you experience any of the following serious side effects stop taking Vizarsin and seek medical help immediately:
Če opazite katerega od naslednjih resnih neželenih učinkov, prenehajte jemati zdravilo in nemudoma poiščite zdravniško pomoč:
You should take Vizarsin about one hour before you plan to have sex.
Zdravilo Vizarsin vzemite približno eno uro pred predvidenim spolnim odnosom.
As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to Vizarsin, before driving or operating machinery.
V kliničnih preizkušanjih s sildenafilom so poročali o omotici in spremembah vida, zato se morajo bolniki zavedati, kako se odzovejo na zdravilo Vizarsin, preden vozijo ali upravljajo stroje.
In the event of a medical emergency, you should tell your doctor, pharmacist or nurse that you have taken Vizarsin and when you did.
Če pride do nujne zdravstvene obravnave, morate zdravniku, farmacevtu ali medicinski sestri povedati, da ste vzeli zdravilo Vizarsin in kdaj ste ga vzeli.
Do not take Vizarsin orodispersible tablets with any other forms of Vizarsin.
Orodisperzibilnih tablet Vizarsin ne smete jemati z nobeno drugo obliko zdravila Vizarsin.
- Seizures or fits - this occurs rarely
- Konvulzije ali napadi - to se zgodi redko
Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance.
Zaviralci teh izoencimov zato lahko zmanjšajo očistek sildenafila, indkutorji teh encimov pa lahko zvišajo očistek sildenafila.
Concomitant use with ritonavir
Sočasna uporaba z ritonavirjem
At 24 hours, the plasma levels of sildenafil were still approximately 200 ng/ml, compared to approximately 5 ng/ml when sildenafil was administered alone.
Po 24 urah je bila koncentracija sildenafila v plazmi še vedno približno 200 ng/ml v primerjavi s približno 5 ng/ml v primeru, ko je bil sildenafil apliciran sam.
Pharmacotherapeutic group: Urologicals, drugs used in erectile dysfunction, ATC code: G04BE03.
Farmakoterapevtska skupina: zdravila za bolezni sečil, zdravila za zdravljenje erektilne disfunkcije; oznaka ATC: G04BE03.
Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.
Pred začetkom kakršnegakoli zdravljenja erektilne disfunkcije mora zdravnik preveriti bolnikovo kardiovaskularno stanje, saj je s spolno dejavnostjo povezana določena stopnja kardialnega tveganja.
Most, but not all, of these patients had pre-existing cardiovascular risk factors.
Večina teh bolnikov je že imela kardiovaskularne dejavnike tveganja.
The side effects reported in association with the use of Vizarsin are usually mild to moderate and of a short duration.
Neželeni učinki, o katerih poročajo v zvezi z jemanjem zdravila Vizarsin, so ponavadi blagi do zmerni in kratkotrajni.
You should not take Vizarsin if you do not have erectile dysfunction.
Zdravila Vizarsin ne smete jemati, če nimate erektilne disfunkcije.
Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue.
Relaksacijski učinek sildenafila na izolirani človeški corpus cavernosum ni neposreden, a močno okrepi relaksacijski učinek NO na to tkivo.
In vivo studies:
Raziskave in vivo:
Vizarsin is not indicated for use by women.
Zdravilo Vizarsin ni indicirano za uporabo pri ženskah.
Vizarsin will only help you to get an erection if you are sexually stimulated.
Zdravilo Vizarsin vam bo pomagalo doseči erekcijo le, če ste spolno stimulirani.
Always tell your doctor, pharmacist or nurse if you are taking any of these medicines that are often used for the relief of angina pectoris (or “chest pain”).
Vedno povejte svojemu zdravniku, farmacevtu ali medicinski sestri, če jemljete katero od teh zdravil, ki se pogosto uporabljajo za lajšanje angine pektoris (bolečine v prsnem košu).
Single doses of antacid (magnesium hydroxide/aluminium hydroxide) did not affect the bioavailability of sildenafil.
Posamični odmerki antacida (magnezijevega ali aluminijevega hidroksida) niso vplivali na biološko uporabnost sildenafila.
Due to age-differences in plasma protein binding, the corresponding increase in free sildenafil plasma concentration was approximately
Zaradi starostno pogojenih razlik v vezavi na beljakovine v plazmi so se plazemske koncentracije prostega sildenafila ustrezno povečale za približno
Since the orodispersible tablet is fragile, it should be taken immediately on opening the blister.
Ker je krhka, jo je treba vzeti takoj po odprtju pretisnega omota.
- Do not use nitrates to treat your chest pain.
- Ne vzemite nitratov, ki jih uporabljate za bolečine v prsnem košu,
Patients with rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose-galactose malabsorption should not take this medicine.
Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle.
To znižanje krvnega tlaka je v skladu z vazodilatacijskimi učinki sildenafila in je verjetno posledica povečane koncentracije cGMP v žilnem gladkem mišičju.
After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/ml (CV 40%).
Po enkratnem 100-mg peroralnem odmerku je srednja največja celotna koncentracija sildenafila v plazmi približno 440 ng/ml (CV 40 %).
Tell your doctor if you are taking any of these medicines which are often given for relief of angina pectoris (or “chest pain”).
Povejte svojemu zdravniku, če jemljete katero od teh zdravil, ki se pogosto uporabljajo za lajšanje angine pektoris (bolečine v prsnem košu).
The recommended starting dose is 50 mg.
Priporočeni začetni odmerek je 50 mg.
Vizarsin is a treatment for adult men with erectile dysfunction, sometimes known as impotence.
Zdravilo Vizarsin je zdravilo za odrasle moške z erektilno disfunkcijo, znano tudi kot impotenca.
Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process.
Raziskave in vitro so pokazale, da je sildenafil selektiven za PDE5, ki je vpletena v erekcijsko dogajanje.
PDE5 inhibitors, such as Vizarsin have been shown to increase the hypotensive effects of this medicine.
Zaviralci PDE5, kot je zdravilo Vizarsin, dokazano povečujejo hipotenzivne učinke tega zdravila.
In the natural setting, i.e. with sexual stimulation, it restores impaired erectile function by increasing blood flow to the penis.
V naravnih okoliščinah, tj. ob spolni stimulaciji, s povečanjem dotoka krvi v penis obnovi okvarjeno erektilno funkcijo.
Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation.
Dve klinični raziskavi sta bili namenjeni oceni časa, v katerem lahko sildenafil po zaužitju odmerka kot odziv na spolno stimulacijo povzroči erekcijo.
Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised (see section 4.4) and in any event the maximum dose of sildenafil should under no circumstances exceed 25 mg within 48 hours.
Glede na te farmakokinetične ugotovitve sildenafila ni priporočljivo jemati sočasno z ritonavirjem (glejte poglavje 4.4), največji odmerek sildenafila pa nikakor ne sme preseči 25 mg v 48 urah.
When the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in increased corpus cavernosum levels of cGMP.
Ko je pot NO/cGMP aktivirana, kot se zgodi pri spolni stimulaciji, zavrtje PDE5 s sildenafilom poveča koncentracijo cGMP v corpusu cavernosumu.
Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity.
Preden zdravnik predpiše sildenafil, mora natančno pretehtati, ali bi lahko takšni vazodilatacijski učinki neželeno vplivali na bolnika, ki imajo določene bolezni, zlasti v kombinaciji s spolno dejavnostjo.
The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina.
Rezultati niso dokazali klinično pomembnih razlik, pri sildenafilu v primerjavi s placebom v času do pojava omejujoče angine pektoris.
It works by helping to relax the blood vessels in your penis, allowing blood to flow into your penis when you get sexually excited.
Deluje tako, da sprosti žile v spolnem udu in omogoči dotok krvi vanj, ko ste spolno vzburjeni.
How to take Vizarsin
Kako jemati zdravilo Vizarsin
The following groups were not well represented or excluded from clinical trials: patients with pelvic surgery, patients post-radiotherapy, patients with severe renal or hepatic impairment and patients with certain cardiovascular conditions (see section 4.3).
Naslednje skupine niso bile zadovoljivo zastopane ali pa so bile iz kliničnih preizkušanj izključene: bolniki po operacijah na medenici, po radioterapiji, s hudo ledvično ali jetrno okvaro in bolniki z nekaterimi kardiovaskularnimi motnjami (glejte poglavje 4.3).
Single oral doses of sildenafil up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG.
Enkratni peroralni odmerek do 100 mg sildenafila pri zdravih prostovoljcih ni povzročil klinično pomembnih sprememb na EKG-ju.
The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied.
Farmakokinetika sildenafila pri bolnikih s hudo jetrno okvaro ni raziskana.
You should not use Vizarsin with treatments for pulmonary arterial hypertension (PAH) containing sildenafil or any other PDE5 inhibitors.
Zdravila Vizarsin ne smete uporabljati skupaj z zdravili za zdravljenje pljučne artetrijske hipertenzije (PAH), ki vsebujejo sildenafil ali katerekoli druge zaviralce PDE5.
Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro.
Raziskave s človeškimi trombociti kažejo, da sildenafil okrepi antiagregacijski učinek natrijevega nitroprusida in vitro.
Table 1: Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through postmarketing surveillance
Preglednica 1: Medicinsko pomembni neželeni učinki, o katerih so v nadzorovanih kliničnih preizkušanjih poročali pogosteje kot pri placebu, in medicinsko pomembni neželeni učinki, o katerih so poročali v obdobju trženja.
Some patients who take alpha-blocker therapy for the treatment of high blood pressure or prostate enlargement may experience dizziness or light-headedness, which may be caused by low blood pressure upon sitting or standing up quickly.
Nekatere bolnike, ki jemljejo antagonist adrenergičnih receptorjev alfa zaradi zdravljenja visokega krvnega tlaka ali zaradi povečanja prostate, lahko v stoječem položaju obide omotica ali vrtoglavica kot posledica nizkega krvnega tlaka, ki se pojavi med sedenjem ali pri prehitrem vstajanju.
Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable (e.g. patients with severe cardiovascular disorders such as unstable angina or severe cardiac failure).
Zdravil za zdravljenje erektilne disfunkcije, vključno s sildenafilom, ne smejo jemati moški, za katere spolna dejavnost ni priporočljiva (npr. bolniki s hudimi kardiovaskularnimi motnjami, kot sta nestabilna angina pektoris ali hudo srčno popuščanje).
- Chest pains - this occurs uncommonly If this occurs during or after intercourse: - Get in a semi-sitting position and try to relax.
- Bolečine v prsnem košu - to se zgodi občasno Če se to zgodi med ali po spolnem odnosu: - se namestite v polsedeči položaj in se poskusite sprostiti.
Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state.
Največjo plazemsko koncentracijo doseže v 30 do 120 minutah (srednji čas je bil 60 minut) po peroralni uporabi na prazen želodec.
Children and adolescents Vizarsin should not be given to individuals under the age of 18.
Otroci in mladostniki Posamezniki do 18. leta starosti ne smejo dobiti zdravila Vizarsin.
Common ( 1/100 and
Pogosti ( 1/100 in
What Vizarsin is and what it is used for What you need to know before you take Vizarsin How to take Vizarsin
Kaj je zdravilo Vizarsin in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Vizarsin Kako jemati zdravilo Vizarsin Možni neželeni učinki
Sildenafil (50 mg) did not potentiate the hypotensive effects of alcohol in healthy volunteers with mean maximum blood alcohol levels of 80 mg/dl.
Sildenafil (50 mg) ni stopnjeval hipotenzivnih učinkov alkohola pri zdravih prostovoljcih s srednjo največjo koncentracijo alkohola v krvi 80 mg/dl.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC, Cmax, tmax, elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite.
Pri normalnih zdravih moških prostovoljcih ni bilo opaziti učinkov azitromicina (tri dni po 500 mg na dan) na AUC, Cmax, tmax, konstanto hitrosti izločanja ali na poznejši razpolovni čas sildenafila oz. njegovega glavnega presnovka v obtoku.
- If you currently have a stomach ulcer, or a bleeding problems (such as haemophilia).
- če imate trenutno razjedo na želodcu ali če imate težave, povezane s krvavitvami (npr. hemofilijo);
Removal of the intact orodispersible tablet from the mouth is difficult.
Orodisperzibilno tableto je iz ust težko odstraniti.
In these study populations, mean additional reductions of supine blood pressure of 7/7 mmHg, 9/5 mmHg, and 8/4 mmHg, and mean additional reductions of standing blood pressure of 6/6 mmHg, 11/4 mmHg, and 4/5 mmHg, respectively, were observed.
Pri populacijah, ki so sodelovale v raziskavah, so opažali povprečno dodatno znižanje krvnega tlaka leže za 7/7 mmHg, 9/5 mmHg in 8/4 mmHg ter dodatno znižanje krvnega tlaka stoje za 6/6 mmHg, 11/4 mmHg in 4/5 mmHg.
- Serious skin reactions - this occurs rarely Symptoms may include severe peeling and swelling of the skin, blistering of the mouth, genitals and around the eyes, fever.
- Resne kožne reakcije - to se zgodi redko Simptomi lahko vključujejo hudo lupljenje in otekanje kože, mehurčke na ustih, spolovilu in okoli oči, vročino.
The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: severe hepatic impairment, hypotension (blood pressure <90/50 mmHg), recent history of stroke or myocardial infarction and known hereditary degenerative retinal disorders such as retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases).
Varnost sildenafila ni raziskana pri naslednjih podskupinah bolnikov, zato je njegova uporaba pri njih kontraindicirana: huda okvara jeter, hipotenzija (krvni tlak < 90/50 mmHg), nedavna možganska kap ali miokardni infarkt in znane dedne degenerativne bolezni mrežnice, npr. retinitis pigmentosa (manjši del teh bolnikov ima genetske motnje mrežničnih fosfodiesteraz).
Since sildenafil (and its major circulating N-desmethyl metabolite) is 96% bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/ml (38 nM).
Ker se sildenafil (in njegov glavni krožeči N-desmetilni presnovek) 96-% veže na beljakovine v plazmi, je srednja največja plazemska koncentracija prostega sildenafila 18 ng/ml (38 nM).
Rare ( 1/10000 and
Redki ( 1/10000 in
What Vizarsin contains - The active substance is sildenafil.
Kaj vsebuje zdravilo Vizarsin - Učinkovina je sildenafil.
Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil.
Koncentracija tega presnovka v plazmi znaša približno 40 % koncentracije sildenafila.
Vizarsin contains sorbitol.
Zdravilo Vizarsin vsebuje sorbitol.
In fixed dose studies, the proportions of patients reporting that treatment improved their erections were 62% (25 mg), 74% (50 mg) and 82% (100 mg) compared to 25% on placebo.
V preizkušanjih z vnaprej določenim odmerkom je bil delež bolnikov, ki so navajali, da jim je zdravilo izboljšalo erekcije, 62-% (25 mg), 74-% (50 mg) oz. 82-% (100 mg) v primerjavi s 25-% deležem pri bolnikih, ki so dobivali placebo.
In addition, initiation of sildenafil at a dose of 25 mg should be considered (see sections 4.4 and 4.5).
Poleg tega je treba razmisliti o uvedbi sildenafila v odmerku po 25 mg (glejte poglavji 4.4 in 4.5).
The corresponding change in supine diastolic blood pressure was 5.5 mmHg.
Ustrezna sprememba diastoličnega krvnega tlaka, merjenega leže, je bila 5,5 mmHg.
Certain patients have experienced these symptoms when taking Vizarsin with alpha-blockers.
Nekateri bolniki so doživeli takšne simptome med jemanjem zdravila Vizarsin z antagonisti adrenergičnih receptorjev alfa.
- If you are taking medicines called nitrates, as the combination may lead to a dangerous fall in your blood pressure.
- Če jemljete zdravila, ki se imenujejo nitrati, ker lahko sočasno jemanje povzroči potencialno nevaren padec vašega krvnega tlaka.
KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenia TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Germany
KRKA, d. d., Novo mesto, Šmarješka cesta 6, 8501 Novo mesto, Slovenija TAD Pharma GmbH, Heinz-Lohmann-Straße 5, 27472 Cuxhaven, Nemčija
A double-blind, placebo-controlled exercise stress trial evaluated 144 patients with erectile dysfunction and chronic stable angina, who regularly received anti-anginal medicinal products (except nitrates).
Dvojno slepa s placebom nadzorovana raziskava z obremenitvenim testiranjem pri 144 bolnikih z erektilno disfunkcijo in kronično stabilno angino pektoris, ki so redno jemali zdravila za zdravljenje angine pektoris (razen nitratov).
The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h.
N-desmetilni presnovek se presnavlja naprej; končni razpolovni čas je približno 4 ure.
Doses of 200 mg did not result in increased efficacy but the incidence of adverse reactions (headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision) was increased.
200-mg odmerek ni bil bolj učinkovit, povečala pa se je pogostost neželenih učinkov (glavobola, zardevanja, omotice, dispepsije, zamašenega nosu, sprememb vida).
In a separate RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation 4-5 hours post-dose.
V posebni raziskavi z RigiScanom so ugotovili, da lahko sildenafil povzroči erekcijo kot odziv na spolno stimulacijo še 4 do 5 ur po zaužitju odmerka.
In a penile plethysmography (RigiScan) study of fasted patients, the median time to onset for those who obtained erections of 60% rigidity (sufficient for sexual intercourse) was 25 minutes (range 12-37 minutes) on sildenafil.
V raziskavi s pletizmografijo penisa (RigiScan) in uporabo sildenafila na prazen želodec je bil srednji čas do začetka delovanja pri bolnikih, ki so dosegli erekcijo s 60-% čvrstostjo (zadostno za spolni odnos), 25 minut (razpon od 12 do 37 minut).
Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, cimetidine).
Analiza podatkov populacijske farmakokinetike v kliničnih raziskavah je pokazala, da se očistek sildenafila zmanjša pri sočasnem jemanju zaviralcev CYP3A4 (npr. ketokonazola, eritromicina, cimetidina).
Adverse reactions from post-marketing surveillance has been gathered covering an estimated period >10 years.
Poročila o neželenih učinkih iz obdobja trženja zajemajo podatke več kot desetih let.
When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension.
Ko so sildenafil in doksazosin sočasno uporabili pri bolnikih, pri katerih bolezen med zdravljenjem z doksazosinom ni napredovala, so poročali o redkih primerih simptomatske posturalne hipotenzije.
Your doctor may start you on a lower dose (25 mg) of Vizarsin.
Zdravnik vam bo za začetek morda predpisal zdravilo Vizarsin v zmanjšanem odmerku (25 mg).
This is most likely to occur within 4 hours post sildenafil dosing (see sections 4.2 and 4.4).
Verjetnost, da se to zgodi, je največja v štirih urah po odmerku sildenafila (glejte poglavji 4.2 in 4.4).
In volunteers with mild to moderate renal impairment (creatinine clearance = 30-80 ml/min), the pharmacokinetics of sildenafil were not altered after receiving a 50 mg single oral dose.
Pri prostovoljcih z blago do zmerno ledvično okvaro (očistek kreatinina 30 do 80 ml/min) farmakokinetika sildenafila po enkratnem 50-mg peroralnem odmerku ni bila spremenjena.
Pregnancy and breast-feeding Vizarsin is not indicated for use by women.
Nosečnost in dojenje Zdravilo Vizarsin ni namenjeno ženskam.