natgillin/translations-raw huggingface dataset:
The Agency's Committee for Medicinal Products for Human Use (CHMP) has concluded that Seroquel XR can be used as add-on to ongoing treatment for major depressive episodes in patients with major depressive disorder who have had sub-optimal response to treatment with other antidepressants.
Odbor za zdravila za uporabo v humani medicini (CHMP) pri agenciji EMEA je zaključil, da se lahko zdravilo Seroquel XR uporablja kot dodatek obstoječemu zdravljenju poglavitnih depresivnih epizod pri bolnikih s poglavitno depresivno motnjo in podoptimalnim odzivom na zdravljenje z drugimi antidepresivi.
The Committee recommended that the medicine be used as add-on to ongoing treatment for major depressive episodes in MDD patients who have had sub-optimal response to monotherapy with another antidepressant.
Odbor je priporočil, da se zdravilo uporablja kot dodatek obstoječemu zdravljenju poglavitnih depresivnih epizod pri bolnikih s poglavitno depresivno motnjo in podoptimalnim odzivom na monoterapijo z drugim antidepresivom.
• is pregnant or might be pregnant.
• noseči ali bi lahko bili noseči.
The combination should be avoided.
Kombinaciji se je treba izogibati.
Clinical efficacy and safety in the paediatric population
Klinična učinkovitost in varnost pri pediatrični populaciji
Frequency not known (reported from use in adults)
Pogostost ni znana (se poroča iz uporabe pri odraslih)
No special treatment is required.
Posebno zdravljenje ni potrebno.
These medicines should be taken in the morning.
Ta zdravila je treba jemati zjutraj;
If this change in behaviour occurs, you must tell your doctor.
Če pride do te spremembe vedenja, morate to povedati zdravniku.
Do not give this medicine to children below the age of 2 years as it has not been tested and its effects are unknown.
Tega zdravila ne dajajte otrokom, mlajšim od 2 let, ker ni bilo preizkušeno in njegovi učinki niso znani.
What it is used for
Za kaj se uporablja
These medicines should be avoided, especially in the evening.
Tem zdravilom se je treba izogibati, zlasti zvečer;
Interaction studies have only been performed in adults.
Študije o medsebojnem delovanju so bile izvedene samo pri odraslih.
Terminal half life (t½) is 3.5-4 hours.
Končni razpolovni čas (t½) je od 3,5 do 4 ure.
Treatment difference (SE)
Razlika v zdravljenju (SE)
For children and adolescents aged 2-18
Za otroke in mladostnike od 2 do 18 let
The treatment effects on sleep variables were associated with improved parents' well-being.
Učinki zdravljenja na spremenljivke spanja so bili povezani z izboljšanim počutjem staršev.
Mood swings, Aggression, Irritability
Nihanje razpoloženja, agresivnost, razdražljivost
p-value*
vrednost p*
Common: may affect between 1 in 100 to 1 in 10 people
pogosti: lahko prizadenejo med 1 od 100 in 1 od 10 ljudi
Data are available for up to 2 years' treatment.
Na voljo so podatki za zdravljenje do dveh let.
This leaflet was last revised in { month/YYYY}.
Navodilo je bilo nazadnje revidirano { mesec/LLLL}.
Bioavailability is in the order of 15%.
Biološka uporabnost znaša 15 %.
The tablets should be taken after the evening meal, i.e. on a full stomach.
Tablete je treba vzeti po večerji, tj. na poln želodec.
4.7 Effects on ability to drive and use machines Melatonin has a moderate influence on the ability to drive and use machines.
4.7 Vpliv na sposobnost vožnje in upravljanja strojev Melatonin ima zmeren vpliv na sposobnost vožnje in upravljanja strojev.
Melatonin is a hormone produced naturally by the body.
Melatonin je hormon, ki ga naravno proizvaja telo.
If an inadequate response has been observed, the dose should be increased to 5 mg, with a maximal dose of 10 mg.
Če je bil ugotovljen neustrezen odziv, je treba odmerek povečati na 5 mg, pri čemer je največji odmerek 10 mg.
There is a significant first pass effect with an estimated first pass metabolism of 85%.
Pomemben je učinek prvega prehoda, pri čemer je ocenjeni metabolizem prvega prehoda 85 %.
A five-fold variability in Cmax between different members of the same sex has also been observed.
Opazili so tudi petkratno spremenljivost Cmax med različnimi predstavniki istega spola.
-3.64,3.89 ns
-3,64, 3,89 ni pomembno
DO NOT take Slenyto if you or your child: - is allergic to melatonin or any of the other ingredients of this medicine (listed in section 6).
NE uporabljajte zdravila Slenyto, če ste vi ali vaš otrok: - alergični na melatonin ali katero koli drugo sestavino tega zdravila (navedeno v poglavju 6).
How long
Kako dolgo
The doctor may want you/your child to stop taking this medicine.
Zdravnik bo morda želel, da vi/vaš otrok prenehate jemati to zdravilo.
• Low levels of white blood cells (neutropenia)
• nizke ravni belih krvničk (nevtropenija)
Treatment was administered for up to two years.
Zdravljenje se je izvajalo do dve leti.
The medicine can help you or your child fall asleep and may help you or your child sleep for longer during the night.
Zdravilo lahko vam ali vašemu otroku pomaga zaspati in morda vam ali vašemu otroku pomaga ponoči spati dlje časa.
The maximum daily dose that you/your child will receive is 10 mg (two 5-mg tablets).
Največji dnevni odmerek, ki ga boste dobili vi/vaš otrok, je 10 mg (dve 5 mg tableti).
Somnolence, Headache, Sudden onset of sleep
Zaspanost, glavobol, nenaden spanec
Therefore the medicinal product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety (see section 4.7).
Zdravilo je zato treba uporabljati previdno, če so učinki zaspanosti lahko povezani s tveganjem za varnost (glej poglavje 4.7).
However, no pharmacodynamic differences between males and females were found despite differences in blood levels.
Vendar farmakodinamičnih razlik med moškimi in ženskami kljub različnim ravnem v krvi niso zaznali.
5- or 8-methoxypsoralen
5- ali 8-metoksipsoralen
It is important to continue taking this medicine to treat the condition.
Za zdravljenje bolezni je pomembno še naprej jemati to zdravilo.
Unexpected changes in behaviour, such as aggression, may occur commonly (affecting between 1 in 100 to 1 in 10 people).
Pogosto se lahko pojavijo nepričakovane spremembe vedenja, kot je agresivnost (med 1 od 100 in 1 od 10 ljudi).
Concomitant use of the following medicinal products is not recommended (see section 4.4):
Sočasna uporaba naslednjih zdravil ni priporočljiva (glejte poglavje 4.4):
Concomitant use of the following medicinal products should be considered with caution:
Pri sočasni uporabi naslednjih zdravil je potrebna previdnost:
A 3-4-fold increase in Cmax is apparent for women compared to men.
Pri ženskah je povečanje Cmax od 3- do 4-kratno v primerjavi z moškimi.
- has liver or kidney problems.
- jetrne ali ledvične težave.
Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Bolniki z redkimi dednimi težavami galaktozne intolerance, popolnega pomanjkanja laktaze ali malabsorpcije glukoze/galaktoze tega zdravila ne smejo jemati.
After at least 3 months of treatment, the physician should evaluate the treatment effect and consider stopping treatment if no clinically relevant treatment effect is seen.
Po vsaj treh mesecih zdravljenja mora zdravnik oceniti učinek zdravljenja in razmisliti o ukinitvi zdravljenja, če ni mogoče opaziti nobenega klinično pomembnega učinka zdravljenja.
Do not drink alcohol before, during or after taking Slenyto, because alcohol weakens the effect of the medicine.
Zdravilo Slenyto z alkoholom Pred, med ali po jemanju zdravila Slenyto ne pijte alkohola, ker alkohol zmanjša učinek zdravila.
If there is no improvement in your/your child's symptoms, your doctor may increase the dose of Slenyto to find the most suitable dose for you/your child.
Če se vaši simptomi/simptomi vašega otroka ne izboljšajo, vam zdravnik lahko poveča odmerek zdravila Slenyto, da ugotovi najprimernejši odmerek za vas/vašega otroka.
The patient should be monitored at regular intervals (at least every 6 months) to check that Slenyto is still the most appropriate treatment.
Bolnika je treba redno spremljati (vsaj vsakih šest mesecev), da se preveri, ali je zdravljenje z zdravilom Slenyto še vedno najprimernejše.
74 patients completed 104 weeks of treatment, 39 completed 2 years and 35 completed 21 months of Slenyto treatment.
74 bolnikov je dokončalo 104 tedne zdravljenja, 39 bolnikov dve leti in 35 bolnikov 21 mesecev zdravljenja z zdravilom Slenyto.
Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu poleg oznake „EXP“.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 20 September 2018
Datum prve odobritve: 20. septembra 2018
• Changes in mood
• spremembe razpoloženja
Slenyto should be taken in the evening, 30 to 60 minutes before bedtime.
Zdravilo Slenyto je treba jemati zvečer, od 30 do 60 minut pred spanjem.
Patients had a significantly decreased total excretion of 6-sulfatoxymelatonin compared with controls.
Pri bolnikih je bilo zelo zmanjšano skupno izločanje 6-sulfatoksimelatonina v primerjavi s kontrolami.
A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from melatonin therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman.
Odločiti se je treba med prenehanjem dojenja ali prenehanjem/prekinitvijo zdravljenja z melatoninom, pri čemer je treba pretehtati prednosti dojenja za otroka in prednosti zdravljenja za mater.
The absorption of orally ingested melatonin is complete in adults and may be decreased by up to 50% in the elderly.
Absorpcija peroralno zaužitega melatonina je pri odraslih popolna, pri starejših bolnikih pa se lahko zmanjša do 50 %.
This finding is compatible with the short half-life of melatonin in humans.
Ta ugotovitev je v skladu s kratkim razpolovnim časom melatonina pri ljudeh.
The tablet should not be broken, crushed or chewed because it will lose the prolonged release properties.
Tableta se ne sme prelomiti, zdrobiti ali žvečiti, ker bi izgubila značilnosti v zvezi s podaljšanim sproščanjem.
In particular, taking Slenyto with the following medicines can increase the risk of side effects, or it can affect the way that Slenyto or the other medicine works:
Zlasti jemanje zdravila Slenyto skupaj z naslednjimi zdravili lahko poveča tveganje neželenih učinkov ali lahko vpliva na način delovanja zdravila Slenyto ali drugih zdravil:
No clinically significant pharmacokinetic interactions were found in each case.
V nobenem primeru niso bile ugotovljene klinično pomembne farmakokinetične interakcije.
If the tablets are mixed with these foods, they should be given immediately and not left or stored, as this may affect the way the tablets work.
Če se tablete zmešajo s temi živili, jih je treba vzeti takoj in se jih ne sme pustiti ali shraniti, ker to lahko vpliva na način njihovega delovanja.
In a clinical trial, there was clear evidence for a transitory pharmacodynamic interaction between melatonin and zolpidem one hour following co-dosing.
V kliničnem preskušanju so se pokazali jasni znaki prehodnega farmakodinamičnega medsebojnega delovanja melatonina in zolpidema eno uro po sočasnem prejemu odmerkov.
The effect of melatonin on newborns/infants is unknown.
Učinek melatonina na novorojenčke/dojenčke ni znan.
Smoking can increase the breakdown of melatonin by the liver, which may make this medicine less effective.
Kajenje lahko poveča razkroj melatonina v jetrih, zaradi česar se lahko zmanjša učinek tega zdravila.
Adjusted treatment means (SE) [95% CI]
Prilagojeno povprečje zdravljenja (SE) [95 % CI]
Please tell your doctor if you or your child starts or stops smoking during treatment.
Obvestite zdravnika, če ste vi ali vaš otrok med zdravljenjem začeli ali prenehali kaditi.
• Swelling and inflammation of the sinuses associated with pain and blocked nose (sinusitis)
• otekanje in vnetje sinusov, povezano z bolečino in zamašenim nosom (sinuzitis)
It is possible that melatonin is passed into human breast milk, therefore your doctor will decide whether you or your daughter should breastfeed whilst taking melatonin.
Mogoče je, da melatonin prehaja v materino mleko, zato bo zdravnik odločil, ali vi ali vaša hči med jemanjem melatonina lahko dojite.
What Slenyto is and what it is used for
Kaj je zdravilo Slenyto in za kaj ga uporabljamo
A slight effect on post-natal growth and viability was found in rats only at very high doses, equivalent to approximately 2000 mg/day in humans.
Na podganah je bil ugotovljen manjši učinek na rast in sposobnost preživetja po rojstvu samo pri zelo visokih odmerkih, ki so ustrezali približno 2 000 mg/dan pri ljudeh.
It is for the treatment of insomnia (sleeplessness) when a healthy sleeping routine (such as a regular bedtime and soothing sleeping environment) has not worked well enough.
Namenjeno je zdravljenju insomnije (nespečnosti), kadar zdrave spalne navade (kot sta odhajanje v posteljo ob istem času in pomirjujoče spalno okolje) ne zadostujejo.
If the tablets are mixed with food or drink, they should be taken immediately and the mixture not stored.
Če se tablete zmešajo s hrano ali pijačo, jih je treba vzeti takoj, mešanica pa se ne sme shraniti.
In the absence of specific studies in children, the drug interactions with melatonin are those known in adults.
Ker posebne študije pri otrocih niso bile izvedene, so interakcije melatonina interakcije, znane pri odraslih.
Combination with thioridazine and imipramine should be avoided.
Kombinaciji s tioridazinom in imipraminom se je treba izogibati.
The principal metabolite is 6-sulfatoxy-melatonin (6-S-MT), which is inactive.
Najpomembnejši metabolit je 6-sulfatoksi-melatonin (6-S-MT), ki ni aktiven.
The activity of melatonin at the melatonin receptors (MT1, MT2 and MT3) is believed to contribute to its sleep-promoting properties, as these receptors (mainly MT1 and MT2) are involved in the regulation of circadian rhythms and sleep regulation.
Predvideva se, da aktivnost melatonina pri receptorjih melatonina (MT1, MT2 in MT3) prispeva k njegovim lastnostim, ki spodbujajo spanje, saj ti receptorji (pretežno MT1 in MT2) sodelujejo pri uravnavanju cirkadianega ritma in uravnavanju spanja.
• Fits (epilepsy)
• napadi (epilepsija)
Published data demonstrate markedly elevated endogenous melatonin levels during daytime hours due to decreased clearance in patients with hepatic impairment (see Section 4.2).
Objavljeni podatki kažejo izrazito povišane ravni endogenega melatonina podnevi zaradi zmanjšanega čiščenja pri bolnikih z jetrno okvaro (glej poglavje 4.2).
Externalizing behaviours
Eksternalizirano vedenje
• Skin lesion
• kožna lezija
France e-mail: regulatory@neurim.com
Francija e-naslov: regulatory@neurim.com
Therefore, interactions between melatonin and other active substances as a consequence of their effect on CYP1A enzymes is possible.
Interakcije med melatoninom in drugimi zdravilnimi učinkovinami so zato mogoče kot posledica njihovega učinka na encime CYP1A.
Pharmacotherapeutic group: Psycholeptics, melatonin receptor agonists, ATC code: N05CH01 Mechanism of action
Farmakoterapevtska skupina: psiholeptiki, agonisti receptorjev melatonina, oznaka ATC: N05CH01 Mehanizem delovanja
Interactions with other medicines
Medsebojno delovanje z drugimi zdravili
Slenyto shortens the time it takes to fall asleep and lengthens the duration of sleep.
Zdravilo Slenyto skrajša čas, potreben, da zaspimo, in podaljša trajanje spanja.
You or your child should be monitored by your doctor at regular intervals (recommended every 6 months) to check that Slenyto is still the right treatment for you/them.
Vaš zdravnik mora vas ali vašega otroka redno spremljati (priporočljivo je vsakih šest mesecev), da preveri, ali je zdravilo Slenyto še vedno pravo zdravljenje za vas/njih.
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Če ste noseči ali dojite, menite, da bi lahko bili noseči, ali načrtujete zanositev, se posvetujte z zdravnikom, preden vzamete to zdravilo.
Concomitant administration resulted in increased impairment of attention, memory and co-ordination compared to zolpidem alone.
Sočasno dajanje je vplivalo na poslabšanje pozornosti, spominskih funkcij in koordinacije v primerjavi z dajanjem samega zolpidema.
The tablets should be swallowed whole and NOT broken, crushed or chewed.
Tablete je treba pogoltniti cele; NE smejo se prelomiti, zdrobiti ali žvečiti.
In studies performed in both adult and juvenile animals, melatonin had no effect on male or female fertility (see section 5.3).
V študijah, izvedenih na odraslih živalih in mladičih, melatonin ni imel učinka na plodnost samcev ali samic (glej poglavje 5.3).
• non-steroidal anti-inflammatory medicines such as aspirin and ibuprofen (used for treating pain and inflammation).
• nesteroidnimi protivnetnimi zdravili, kot sta aspirin in ibuprofen (ki se uporabljajo za zdravljenje bolečine in vnetja).
Tell your doctor or pharmacist if you or your child is taking, has recently taken or might take any other medicines.
Obvestite zdravnika ali farmacevta, če vi ali vaš otrok jemljete, sta pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
If the tablets are mixed with any other type of food, the tablets may not work properly.
Če se tablete zmešajo z drugimi vrstami živil, morda ne bodo pravilno delovale.
The effect of any stage of renal impairment on melatonin pharmacokinetics has not been studied.
Učinka ledvične okvare katere koli stopnje na farmakokinetiko melatonina še niso raziskovali.
Animal studies do not indicate reproductive toxicity (see section 5.3).
Študije na živalih ne navajajo strupenosti za razmnoževanje (glej poglavje 5.3).
Concomitant use with fluvoxamine, alcohol, benzodiazepines/non-benzodiazepines hypnotics, thioridazine and imipramine is not recommended (see section 4.5).
Sočasna uporaba s fluvoksaminom, alkoholom, benzodiazepinskimi/nebenzodiazepinskimi hipnotiki, tioridazinom in imipraminom ni priporočljiva (glejte poglavje 4.5).
Taking more than the recommended daily dose may make you/your child feel drowsy.
Zaradi odmerka, ki presega priporočeni dnevni odmerek, se boste lahko vi/vaš otrok počutili zaspani.
Alcohol should not be taken with melatonin, because it reduces the effectiveness of melatonin on sleep.
Alkohol Pri jemanju melatonina ni dovoljeno uživati alkohola, ker zmanjšuje učinek melatonina na spanje.
The whole tablets can be put into food like yoghurt, orange juice or ice-cream to help with swallowing.
Cele tablete se lahko dajo v hrano, na primer v jogurt, pomarančni sok ali sladoled, da se lažje pogoltnejo.
Other medicines and Slenyto
Druga zdravila in zdravilo Slenyto
• beta-blockers (used to control blood pressure).
• beta zaviralci (ki se uporabljajo za obvladovanje krvnega tlaka).
Thioridazine and imipramine
Tioridazin in imipramin
Beta-blockers may supress the night-time release of endogenous melatonin and thus should be administered in the morning.
Beta zaviralci lahko ponoči zmanjšajo sproščanje endogenega melatonina, zato jih je treba jemati zjutraj.
5 mg strength
jakost 5 mg
However, melatonin co-administration resulted in increased feelings of tranquility and difficulty in performing tasks compared to imipramine alone, and increased feelings of “muzzyheadedness” compared to thioridazine alone.
Vendar je hkratno dajanje melatonina povzročilo povečan občutek mirnosti in težave pri izvajanju nalog v primerjavi z dajanjem samega imipramina, ter povečan občutek „topoglavosti“ v primerjavi s samim tioridazinom.
The improvements in total sleep time (TST), sleep latency (SL) and duration of uninterrupted sleep (LSE; longest sleep episode) seen in the double blind-phase were maintained throughout the 39 weeks' follow up period.
Izboljšanje skupnega časa spanja (TST), latence uspavanja (SL) in neprekinjenega trajanja spanja (LSE; najdaljša epizoda spanja), opaženo v dvojno slepi fazi, se je ohranilo vseh 39 tednov nadaljevalnega obdobja.
The in vitro plasma protein binding of melatonin is approximately 60%.
Vezava in vitro melatonina na plazemske beljakovine je približno 60 %.
Prepubertal children and young adults metabolize melatonin faster than adults.
Otroci pred puberteto in mladi odrasli presnavljajo melatonin hitreje kot odrasli.
Melatonin does not induce CYP1A2 or CYP3A enzymes in vitro at supra-therapeutic concentrations.
Melatonin ne inducira encimov CYP1A2 ali CYP3A in vitro pri koncentracijah, višjih, kot so terapevtske.
The adjusted estimated treatment differences were 43.2 minutes in the all Randomized Set (MI, p=0 .039).
Prilagojena ocenjena razlika v zdravljenju je v celotni randomizirani skupini znašala 43,2 minute (MI, p = 0,039).
Data in animals indicate maternal transfer of melatonin to the foetus via the placenta or in the milk.
Podatki pri živalih kažejo, da se melatonin iz matere prek placente prenaša v zarodek ali v mleko.
After 2 weeks withdrawal on placebo, a descriptive reduction in most scores was seen but levels were still significantly better than baseline levels with no signs of rebound effects.
Po dveh tednih prenehanja jemanja zdravila Slenyto in začetku jemanja placeba je bilo opaženo opisno znižanje večine ocen, vendar so bile ravni še vedno bistveno višje od izhodiščnih, brez znakov povratnega učinka.
If a lower treatment effect is seen after titration to a higher dose, the prescriber should first consider a down-titration to a lower dose before deciding on a complete discontinuation of treatment.
Če je po povečanju odmerka opaziti manjši učinek zdravljenja, mora zdravnik, ki predpiše zdravilo, najprej razmisliti o zmanjšanju odmerka, preden se odloči za popolno ukinitev zdravljenja.
However as melatonin is mainly eliminated via liver metabolism, and the metabolite 6SMT is inactive, renal impairment is not expected to influence clearance of melatonin.
Ker se melatonin izloči večinoma prek jetrnega metabolizma in ker metabolit 6-SMT ni aktiven, ni mogoče pričakovati vpliva ledvične okvare na čiščenje melatonina.
30 months (PVC/PVDC blister) 18 months (HDPE bottle)
30 mesecev (pretisni omot PVC/PVDC) 18 mesecev (plastenka HDPE)
The kinetics of melatonin are linear over the range of 2-8 mg.
Kinetika melatonina je linearna v razponu od 2 mg do 8 mg.
Combination with benzodiazepines and non-benzodiazepine hypnotics should be avoided.
Kombinaciji z benzodiazepinskimi in nebenzodiazepinskimi hipnotiki se je treba izogibati.
Melatonin is mainly bound to albumin, alpha1-acid glycoprotein and high density lipoprotein.
Melatonin se veže večinoma na albumin, alfa1-kisli glikoprotein in lipoprotein visoke gostote.
- suffers from an autoimmune disease (where the body's own immune (defence) system attacks parts of the body).
- avtoimunsko bolezen (ko lasten imunski (obrambni) sistem telesa napade dele telesa).
Crushing and chewing damages the special properties of the tablet and means that they will not work properly.
Z drobljenjem in žvečenjem se poslabšajo posebne značilnosti tablete, kar pomeni, da ne bodo pravilno delovale.
• quinolones (for example ciprofloxacin and norfloxacin) and rifampicin (used in the treatment of bacterial infections)
• kinoloni (kot sta ciprofloksacin in norfloksacin) in rifampicinom (ki se uporablja za zdravljenje bakterijskih okužb);
For social functioning (CGAS), the differences between Slenyto and placebo were small and not statistically significant (Table 1).
Razlike v socialnem vedenju (CGAS) so bile med zdravilom Slenyto in placebom majhne in statistično nepomembne (preglednica 1).
Elimination is by renal excretion of metabolites, 89% as sulfated and glucoronide conjugates of 6-hydroxymelatonin (over 80% as 6-sulfatoxy melatonin) and 2% is excreted as melatonin (unchanged active substance).
Odstrani se z izločanjem metabolitov skozi ledvice, 89 % kot sulfatni in glukuronidni konjugati 6-hidroksimelatonina (več kot 80 % kot 6-sulfatoksi melatonin), 2 % pa se izločita kot melatonin (nespremenjena zdravilna učinkovina).