natgillin/translations-raw huggingface dataset:
Nonclinical studies in rats indicate:
Predklinične študije na podganah kažejo:
• Approximately 50 ml of water to prepare the suspension
• približno 50 ml vode za pripravo suspenzije
Primary analysis for double blind period
Primarna analiza za dvojno slepo obdobje študije.
Three minutes must be allowed for suspension to occur.
Vsebino je treba pustiti tri minute, da nastane suspenzija.
Laboratory tests and monitoring
Laboratorijske preiskave in spremljanje
Proportion of patients (%)
Delež bolnikov (%)
• 1 small glass (maximum size 100 ml)
• 1 majhen kozarec (največ 100-mililitrski)
Wash and dry your hands.
Umijte si roke in si jih obrišite.
• swelling of the face, lips, tongue or throat (signs of angioedema)
• otekanje obraza, ustnic, jezika ali grla (znaki angioedema)
Concomitant ketogenic diet
Sočasna uporaba ketogene diete
The efficacy results for the primary endpoint are summarised in Table 5.
Rezultati učinkovitosti za primarni cilj opazovanja so povzeti v preglednici 5.
Efavirenz, nevirapine
efavirenz, nevirapin
However, the exact mechanism of action in the reduction of seizures associated with TSC is not fully elucidated.
Vendar pa natančen mehanizem delovanja pri zmanjšanju pogostnosti epileptičnih napadov, povezanih s TSC, ni povsem pojasnjen.
No efficacy data available in elderly patients
Podatkov o učinkovitosti pri starejših bolnikih ni na voljo.
Thirteen patients (46%) had a secondary smaller SEGA, including 12 in the contralateral ventricle.
Trinajst bolnikov (46 %) je imelo še drugi manjši SEGA, pri čemer jih je bilo 12 lociranih v kontralateralnem ventriklu.
The stability of the ready to use suspension has been demonstrated for 60 minutes.
Stabilnost pripravljene suspenzije je dokazana za obdobje 60 minut.
Reactivation of infection is an expected reaction during periods of immunosuppression.
Reaktivacija okužbe je v obdobju zaviranja imunskega odziva pričakovana reakcija.
General supportive measures should be initiated in all cases of overdose.
V vseh primerih prevelikega odmerjanja je treba uvesti splošne podporne ukrepe.
Individualised dose titration can be based on simple proportion:
Za osnovo individualiziranega titriranja odmerka je mogoče vzeti preprosto razmerje:
However, there are no clinical data with this dose adjustment.
Vendar pa ni nobenih kliničnih podatkov o takem prilagajanju odmerkov.
Consistently take only the tablets or only the dispersible tablets, and never a combination of both.
Dosledno jemljite samo tablete ali samo disperzibilne tablete, nikoli pa kombinacije obeh.
The grades follow CTCAE Version 3.0 and 4.03.
Stopnje so usklajene z različicama CTCAE 3.0 in 4.03.
Hence, everolimus is considered to contribute the majority of the overall pharmacological activity.
Zato velja, da everolimus prispeva večino skupne farmakološke aktivnosti.
if you have had recent major surgery, or if you still have an unhealed wound following surgery.
če ste imeli nedavno večjo operacijo ali imate še vedno nezaceljeno rano po operaciji.
Increased exposure expected (the effect varies widely).
Mogoče je pričakovati povečano izpostavljenost zdravilu (učinki so lahko zelo različni).
Women who could potentially become pregnant must use highly effective contraception during treatment, and for up to 8 weeks after ending treatment.
Ženske, ki bi lahko zanosile, morajo med zdravljenjem in do 8 tednov po zaključku zdravljenja uporabljati zelo učinkovito kontracepcijo.
Reduction in seizure frequency was sustained over an evaluation period of approximately 2 years.
Zmanjšanje pogostnosti epileptičnih napadov se je ohranilo v obdobju ocenjevanja približno 2 leti.
No specific excretion studies have been undertaken in cancer patients; however, data are available from the studies in transplant patients.
Posebnih študij izločanja pri bolnikih z rakom niso izvajali, so pa na voljo podatki iz študij z bolniki po presaditvi.
Votubia is not recommended for use in patients:
Uporaba zdravila Votubia ni priporočena za bolnike:
Instructions for patients or caregivers preparing the suspension using a small glass:
Navodila za bolnike ali negovalce, ki pripravljajo suspenzijo z uporabo majhnega kozarčka:
A complete and illustrated set of instructions for use is provided at the end of the package leaflet “Instructions for use”.
Celotna navodila z ilustracijami so prikazana na koncu navodila za uporabo pod naslovom “Navodila za uporabo”.
Some infections may be severe and may have fatal consequences in adults and children.
Nekatere okužbe so lahko hude in se lahko končajo s smrtjo, tako pri odraslih kot pri otrocih.
Note: The amount of water in the oral syringe does not need to be exact but all the tablets should be covered.
Opozorilo: Ni treba, da je količina vode v brizgi povsem natančno odmerjena, vendar mora voda pokriti vse tablete.
Frequency categories are defined using the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data).
Kategorije pogostnosti so opredeljene po naslednjem dogovoru: zelo pogosti (≥1/10); pogosti (≥1/100 do <1/10); občasni (≥1/1.000 do <1/100); redki (≥1/10.000 do <1/1.000); zelo redki (<1/10.000), neznana (ni mogoče oceniti iz razpoložljivih podatkov).
Votubia could harm an unborn baby and is not recommended during pregnancy.
Zdravilo Votubia lahko škoduje nerojenemu otroku in med nosečnostjo ni priporočeno.
The use of corticosteroids may be indicated.
Včasih je indicirana uporaba kortikosteroidov.
Pale stools or dark urine may also be signs of hepatitis.
Tudi bledo blato in temno obarvan urin sta lahko znaka hepatitisa.
Partial seizures start by only affecting one side of the brain but can spread and extend to larger areas on both sides of the brain (called a “secondary generalisation”).
Žariščni epileptični napadi se pričnejo s prizadetostjo ene strani možganov, lahko pa se razširijo na večja področja na obeh straneh možganov (to imenujemo »sekundarna generalizacija«).
Store them in a dry and clean place until next time.
Do naslednje uporabe ju shranite na suho in čisto mesto.
Votubia must be administered orally once daily at the same time every day, consistently either with or without food (see section 5.2).
Zdravilo Votubia je treba vzeti peroralno enkrat na dan, vsak dan ob istem času, vedno s hrano ali vedno brez nje (glejte poglavje 5.2).
Do not store above 25°C.
Shranjujte pri temperaturi do 25 C.
• difficulty breathing or swallowing
• težave z dihanjem ali požiranjem
Read and follow these instructions carefully so that you know how to correctly prepare the medicine.
Preberite ta navodila in jih skrbno upoštevajte, da si boste znali pravilno pripraviti zdravilo.
Votubia may affect the way some other medicines work.
Zdravilo Votubia lahko vpliva na delovanje nekaterih drugih zdravil.
≥6 years
≥6 let
What Votubia is and what it is used for
Kaj je zdravilo Votubia in za kaj ga uporabljamo
Do not use this medicine after the expiry date which is stated on the carton and blister foil.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in foliji pretisnega omota.
Name and address of the manufacturer responsible for batch release Novartis Pharma GmbH
Ime in naslov izdelovalca, odgovornega za sproščanje serij Novartis Pharma GmbH
All patients receiving at least one dose of everolimus were followed until drug discontinuation or study completion.
Vse bolnike, ki so prejeli vsaj en odmerek everolimusa, so spremljali do ukinitve zdravila ali do zaključka študije.
Plasma protein binding is approximately 74% both in healthy subjects and in patients with moderate hepatic impairment.
Vezava na proteine v plazmi je približno 74-odstotna tako pri zdravih osebah kot pri bolnikih z zmerno okvaro jeter.
Percentage reduction from baseline, n (%)
Odstotek zmanjšanja od izhodišča, n (%)
Votubia may have a minor or moderate influence on the ability to drive and use machines.
Zdravilo Votubia ima blag ali zmeren vpliv na sposobnost vožnje in upravljanja strojev.
Treatment should continue as long as clinical benefit is observed or until unacceptable toxicity occurs.
Z zdravljenjem je treba nadaljevati, dokler prinaša klinične koristi oziroma dokler ne pride do nesprejemljivih toksičnih učinkov.
The incidence of skeletal variations and malformations (e.g. sternal cleft) was increased at 0.3 and 0.9 mg/kg.
Pogostost sprememb in malformacij okostja (na primer razcepa prsnice) je bila pri odmerkih 0,3 in 0,9 mg/kg povečana.
Patients were treated with concomitant and stable dose of 1 to 3 antiepileptics prior to study entry.
Bolnike so sočasno zdravili s stabilnimi odmerki 1 do 3 antiepileptikov že pred vključitvijo v študijo.
Not evaluable
Ni mogoče oceniti
The mean elimination half-life of everolimus is approximately 30 hours.
Povprečni razpolovni čas izločanja everolimusa je približno 30 ur.
The contents should be gently stirred with a spoon and then administered immediately.
Vsebino je treba nežno premešati z žličko in jo takoj nato zaužiti.
Votubia contains lactose (milk sugar).
Zdravilo Votubia vsebuje laktozo (mlečni sladkor).
Patients ≥18 years of age:
Bolniki, stari manj kot 18 let:
When possible, the same assay and laboratory for therapeutic drug monitoring should be used throughout the treatment.
Če je mogoče, je treba za terapevtsko spremljanje uporabe zdravila ves čas zdravljenja uporabljati enak test in isti laboratorij.
It is not known whether everolimus is excreted in human breast milk.
Ni znano, ali se everolimus izloča v materino mleko pri človeku.
This is because these can also be affected by Votubia.
To je potrebno zato, ker zdravilo Votubia lahko vpliva tudi nanje.
Patients should be advised to be cautious when driving or using machines if they experience fatigue during treatment with Votubia.
Bolnike je treba opozoriti, naj bodo previdni pri vožnji in upravljanju strojev, če pri njih v času zdravljenja z zdravilom Votubia prihaja do utrujenosti.
If you have fever or other signs of an infection, consult with your doctor.
Če imate zvišano telesno temperaturo ali druge znake okužbe, se posvetujte s svojim zdravnikom.
Patients should be advised to report promptly any new or worsening respiratory symptoms.
Bolnikom je treba naročiti, da takoj sporočijo, če bi prišlo do novih respiratornih simptomov ali do poslabšanja obstoječih.
A limited number of paediatric patients have been exposed to doses higher than 10 mg/m 2/day.
Manjše število pediatričnih bolnikov je bilo izpostavljeno odmerkom, ki so presegali 10 mg/m2/dan.
For further details on handling, see section 6.6.
Za več podatkov o ravnanju z zdravilom glejte poglavje 6.6.
If necessary, drink additional water to wash out any residues in your mouth.
Če je treba, popijte še malo vode, s katero poplaknete preostanek zdravila v ustih.
New everolimus dose = current dose x (target concentration / current concentration)
novi odmerek everolimusa = trenutni odmerek x (ciljna koncentracija / trenutna koncentracija)
These instructions are for taking a dose between 1 mg and 10 mg.
Naslednja navodila so primerna samo za jemanje odmerkov med 1 mg in 10 mg.
Exact 95% CI obtained using Clopper-Pearson method b
b a eksaktni 95-odstotni interval zaupanja po Clopper-Pearsonovi metodi b
Gently stir the contents of the glass with a spoon and then proceed immediately to step 8.
Vsebino kozarca nežno premešajte z žličko in takoj nadaljujte z 8. korakom.
No data are available (see sections 5.1 and 5.2).
Podatkov ni na voljo (glejte poglavji 5.1 in 5.2).
Itraconazole, posaconazole, voriconazole
itrakonazol, posakonazol, vorikonazol
Therefore, women taking everolimus should not breast-feed during treatment and for 2 weeks after the last dose.
Zato ženske, ki jemljejo everolimus, ne smejo dojiti v času zdravljenja in še 2 tedna po prejemu zadnjega odmerka.
if you have previously had hepatitis B, because this may occur again during treatment with Votubia (see section 4 ‘Possible side effects').
če ste imeli kdaj prej hepatitis B, ker med zdravljenjem z zdravilom Votubia virus lahko postane ponovno aktiven (glejte poglavje 4 “Možni neželeni učinki”).
Angiomyolipoma progressions were observed in 14.3% of the patients.
Napredovanje angiomiolipoma so opažali pri 14,3 % bolnikov.
AUC ↓63% (range 0-80%) Cmax ↓58% (range 10-70%)
AUC ↓63 % (od 0 do 80 %) Cmax ↓58 % (od 10 do 70 %)
The same pharmaceutical form must be used consistently, as appropriate for the indication being treated.
Dosledno je treba uporabljati isto farmacevtsko obliko zdravila, ki ustreza indikaciji, zaradi katere je bolnik zdravljen.
Symptoms may include swelling and/or pain in one of your legs, usually in the calf, redness or warm skin in the affected area
Simptomi lahko vključujejo otekanje in/ali bolečine v nogi, običajno v mečih, pordela ali topla koža na prizadetem mestu.
Therapeutic drug monitoring
Terapevtsko spremljanje uporabe zdravila
Clinical study results did not show an impact of Votubia on growth and pubertal development.
Rezultati kliničnih študij niso pokazali vpliva zdravila Votubia na rast in spolno dozorevanje.
Tell your doctor if you experience any excessive thirst or increased frequency of urination.
Zdravniku povejte, če ste prekomerno žejni ali urinirate pogosteje kot prej.
Important information for caregivers
Pomembne informacije za negovalce
The incidence of Grade 1 stomatitis was 18.8% (n=16/85) and no cases of Grade 3 or 4 stomatitis were reported.
Pogostnost stomatitisa stopnje 1 je bila 18,8 % (n=16/85), pri čemer niso poročali o nobenem primeru stomatitisa stopnje 3 ali 4.
Hypersensitivity to the active substance, to other rapamycin derivatives or to any of the excipients listed in section 6.1.
Preobčutljivost na učinkovino, na druge derivate rapamicina ali katero koli pomožno snov, navedeno v poglavju 6.1.
Dosing is individualised based on Body Surface Area (BSA) using the Dubois formula, where weight (W) is in kilograms and height (H) is in centimetres:
Odmerjanje je treba prilagoditi vsakemu posameznemu bolniku glede na njegovo telesno površino (BSA) po formuli Dubois, v kateri je telesna masa (W) izražena v kilogramih, telesna višina (H) pa v centimetrih:
mTOR is a key serine-threonine kinase, the activity of which is known to be upregulated in a number of human cancers.
mTOR je serin/treonin-kinaza ključnega pomena, za katere aktivnost je znano, da je pri človeku povečana pri številnih rakavih boleznih.
However, in rats, everolimus and/or its metabolites readily pass into the milk (see section 5.3).
Pri podganah everolimus in/ali njegovi metaboliti brez težav prehajajo v mleko (glejte poglavje 5.3).
≤5 ng/ml >5 ng/ml Difference Difference is “≤5 ng/ml” minus “>5 ng/ml”
≤5 ng/ml >5 ng/ml razlika razlika je vrednost kategorije“≤5 ng/ml” minus vrednost kategorije“>5 ng/ml”
Most of the side effects are mild to moderate and will generally disappear if your treatment is interrupted for a few days.
Neželeni učinki so večinoma blago do zmerno izraženi in večinoma izzvenijo, če zdravljenje za nekaj dni prekinete.
Do not take Votubia if you are allergic to everolimus, to related substances such as sirolimus or temsirolimus, or to any of the other ingredients of this medicine (listed in section 6).
Ne jemljite zdravila Votubia če ste alergični na everolimus, na spojine, ki so sorodne everolimusu, na primer na sirolimus ali temsirolimus, ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
The overall type, frequency and severity of adverse reactions observed in children and adolescents have been generally consistent with those observed in adults, with the exception of infections which were reported at a higher frequency and severity in children below the age of 6 years.
Vrste, pogostnost pojavljanja in stopnja izraženosti neželenih učinkov, ki so jih opažali pri otrocih in mladostnikih, so se večinoma ujemale s tistimi, ki so jih opažali pri odraslih, z izjemo okužb, pri katerih so poročali o večji pogostnosti in močnejši izraženosti pri otrocih, mlajših od 6 let.
Stable disease Progression
Stabilna bolezen
Everolimus is a selective mTOR (mammalian target of rapamycin) inhibitor.
Everolimus je selektiven zaviralec mTOR (tarče rapamicina pri sesalcih - mammalian target of rapamycin).
Frequency based upon number of women from 10 to 55 years of age while on treatment in the pooled data
Pogostnost temelji na številu žensk, ki so bile v času zdravljenja stare od 10 do 55 let, iz združene baze podatkov.
However products containing alcohol, hydrogen peroxide, iodine and thyme derivatives should be avoided as they may exacerbate the condition.
Pri tem pa se je treba izogibati izdelkom za izpiranje ust, ki vsebujejo alkohol, vodikov peroksid, jod ali izvlečke timijana, ker bi lahko poslabšali stanje.
Two primary regulators of mTORC1 signalling are the oncogene suppressors tuberin-sclerosis complexes 1 & 2 (TSC1, TSC2).
Primarna regulatorja signaliziranja z mTORC1 sta dva onkogen supresorja, in sicer tuberin-sklerozna kompleksa 1 & 2 (TSC1 in TSC2).
Other medicines and Votubia
Druga zdravila in zdravilo Votubia
Patients were randomised in a 2:1 ratio to receive either Votubia or matching placebo.
Bolnike so randomizirali v razmerju 2:1 tako, da so prejemali bodisi zdravilo Votubia ali ustrezen placebo.
If you have any questions about Votubia or why it has been prescribed for you, ask your doctor.
Če imate vprašanja o zdravilu Votubia ali vas zanima, zakaj so vam ga predpisali, se obrnite na svojega zdravnika.
Everolimus is not recommended during pregnancy and in women of childbearing potential not using contraception.
Uporaba everolimusa ni priporočena med nosečnostjo in pri ženskah v rodni dobi, ki ne uporabljajo kontracepcije.
(see sections 4.2 and 5.2).
(glejte poglavje 5.2).
Large increase in everolimus concentration is expected.
Mogoče je pričakovati veliko zvišanje koncentracije everolimusa.
No patient developed new lesions, worsening hydrocephalus or increased intracranial pressure, and none required surgical resection or other therapy for SEGA.
Pri nobenem od bolnikov ni prišlo do razvoja novih lezij, poslabšanja hidrocefalusa ali do zvišanja intrakranialnega tlaka in pri nobenem ni bila potrebna kirurška odstranitev ali drugo zdravljenje SEGA.
The non-clinical safety profile of everolimus was assessed in mice, rats, minipigs, monkeys and rabbits.
Predklinični varnostni profil everolimusa so ocenjevali pri miših, podganah, prašičkih, opicah in kuncih.
Wait for 3 minutes until the dispersible tablets have completely broken apart.
Počakajte 3 minute, da disperzibilne tablete povsem razpadejo.
In the absence of clinical data, the possibility of an additive effect on adverse events cannot be excluded when everolimus is given in conjunction with a ketogenic diet.
Ob odsotnosti kliničnih podatkov ne moremo izključiti možnosti aditivnih učinkov na neželene učinke, kadar se everolimus daje sočasno s ketogeno dieto.
The p-values for superiority versus placebo were 0.003 (LT) and <0.001 (HT).
P-vrednosti superiornosti v primerjavi s placebom so bile 0,003 (LT) in < 0,001 (HT).
Administration of everolimus for up to 2 years did not indicate any oncogenic potential in mice and rats up to the highest doses, corresponding respectively to 4.3 and 0.2 times the estimated clinical exposure.
Uporaba everolimusa v trajanju do 2 leti ni pokazala onkogenega potenciala pri miših in podganah do najvišjih odmerkov, ki so ustrezali 4,3-kratniku oziroma 0,2-kratniku ocenjene klinične izpostavljenosti.
Best overall angiomyolipoma response - % Response
Najboljši skupni odziv angiomiolipoma - % Odziv
Carefully remove the oral syringe from the patient's mouth.
Previdno potegnite brizgo iz bolnikovih ust.
In the oncology safety pooling, 37% of the patients treated with everolimus were ≥65 years of age.
Po združenih podatkih o onkološki varnosti zdravila je bilo 37 % bolnikov, ki so prejemali everolimus, starih ≥65 let.
Votubia may elevate cholesterol and/or other blood fats.
Zdravilo Votubia lahko zviša raven holesterola in/ali drugih maščob v krvi.
Everolimus can reduce levels of vascular endothelial growth factor (VEGF).
Everolimus lahko zniža koncentracijo rastnega dejavnika za žilni endotelij (VEGF-vascular endothelial growth factor).
Monitoring of renal function is recommended (see section 4.4).
Priporočeno je spremljanje delovanja ledvic (glejte poglavje 4.4).
9/l) and no fever.
9/l) in telesna temperatura ni več zvišana.
If you receive Votubia for the treatment of TSC with angiomyolipoma of the kidney, the usual dose is 10 mg, to be taken once daily.
Če zdravilo Votubia prejemate za zdravljenje tuberozne skleroze z angiomiolipomom ledvice, znaša običajen odmerek 10 mg, ki ga je treba vzeti enkrat na dan.
In patients with advanced solid tumours, Vd was 191 l for the apparent central compartment and 517 l for the apparent peripheral compartment.
Pri bolnikih z napredovalim trdim tumorjem je volumen porazdelitve 191 l za navidezni centralni prostor in 517 l za navidezni periferni prostor.
Physicians and patients should be aware of the increased risk of infection with Votubia.
Zdravniki in bolniki se morajo zavedati, da zdravilo Votubia povečuje tveganje za okužbe.
There was evidence of reversibility.
Opažali so znake reverzibilnosti teh sprememb.
Follow all the doctor's instructions carefully.
Skrbno se držite njegovih navodil.
The suspension can be prepared either in an oral syringe or in a small glass.
Suspenzijo je mogoče pripraviti bodisi v brizgi za peroralno dajanje ali v majhnem kozarcu.
Other symptoms may include altered kidney function test (increase in creatinine).
Drugi simptomi lahko vključujejo spremenjene rezultate pri preverjanjih delovanja ledvic (zvišane ravni kreatinina).
St John's Wort (Hypericum perforatum)
šentjanževka (Hypericum Perforatum)
In the total population, 57.3% of patients were male and 93.2% were Caucasian.
V celotni populaciji je bilo 57,3 % moških in 93,2 % belcev.
If you experience any of these side effects, tell your doctor immediately as this might have lifethreatening consequences.
Če opazite katerega od navedenih neželenih učinkov, takoj obvestite zdravnika, ker imajo ti neželeni učinki lahko življenjsko nevarne posledice.
If a higher dose or number of tablets is required, an additional glass must be prepared.
Če je potreben višji odmerek ali večje število tablet, je treba pripraviti še en kozarec.
The effect of a ketogenic diet may be mediated through mTOR inhibition.
Ketogena dieta morda učinkuje prek inhibicije mTOR.
mTORC1 activation leads to a downstream kinase signalling cascade, including activation of the S6 kinases.
Aktivacija kompleksa mTORC1 sproži kaskado signaliziranja s kinazami, kar vključuje tudi aktivacijo S6 kinaze.
• The radioactive metabolites of [3H]everolimus do not significantly cross the blood-brain barrier.
• da radioaktivni metaboliti [3H]everolimusa v večji meri ne prehajajo skozi krvno-možgansko pregrado;
The filled syringe should be placed into a container (with the tip pointing up) for 3 minutes, until the Votubia dispersible tablets are in suspension.
Napolnjeno brizgo je treba postaviti v vsebnik (z vrhom obrnjenim navzgor) za 3 minute, dokler disperzibilne tablete Votubia ne razpadejo v suspenzijo.
The immune response to vaccination may be affected and, therefore, vaccination may be less effective during treatment with Votubia.
Zdravilo Votubia lahko vpliva na imunski odziv na cepljenje, zato je lahko cepljenje med zdravljenjem z zdravilom Votubia manj učinkovito.
Removing air
Odstranjevanje zraka
If a dose is missed, the patient should not take an additional dose, but take the usual prescribed next dose.
Če bolnik pozabi vzeti odmerek, naj ne jemlje dodatnega odmerka, temveč naj vzame samo naslednji predpisani odmerek.
Refill the glass with the same amount of water (approximately 30 ml), gently stir the remaining content and drink the whole amount to make sure that you get the full dose of Votubia tablets.
V kozarec natočite enako količino vode (približno 30 ml vode), rahlo premešajte s preostankom v kozarcu in spijte celotno vsebino do konca, da zagotovite zaužitje celotnega odmerka zdravila iz tablet Votubia.
This may result in the need for insulin and/or oral antidiabetic agent therapy.
Morda boste zato potrebovali insulin in/ali peroralna antidiabetična zdravila.