natgillin/translations-raw huggingface dataset:
• Losec can be given to adults including the elderly.
• Zdravilo Losec lahko dobijo odrasli, vključno s starejšimi osebami.
DO NOT USE milk or carbonated water.
Ne uporabljajte mleka ali gazirane vode.
There may also be severe blisters and bleeding in the lips, eyes, mouth, nose and genitals.
Pojavijo se lahko tudi hudi mehurji in krvavitve na ustnicah, očeh, ustih, nosu in spolovilih.
Once complete relief of symptoms has occurred, treatment should be discontinued.
Ko so simptomi povsem odpravljeni, je treba zdravljenje končati.
Always take Losec exactly as described in this leaflet.
Zdravilo Losec vedno jemljite natančno tako, kot je opisano v tem navodilu.
• Low levels of sodium in the blood.
• nizka raven kalija v krvi.
It is important for you to give information about your medicine at this time.
V takšnem primeru je pomembno, da mu poveste za svoje zdravilo.
The entire contents of each vial is to be dissolved in approximately 5 ml and then immediately diluted to 100 ml.
Celotno vsebino vsake viale je treba raztopiti v približno 5 ml in potem nemudoma razredčiti do 100 ml.
This will depend on your condition and how old you are.
To bo odvisno od vaše bolezni in vaše starosti.
Ask your pharmacist if you need more information or advice.
- Posvetujte se s farmacevtom, če potrebujete dodatne informacije ali nasvet.
The frequency of vomiting/regurgitation episodes decreased by 50% after 8 weeks of treatment irrespective of the dose.
Pogostnost pojavov bruhanja ali regurgitacije se je po 8 tednih zdravljenja zmanjšala za 50 %, ne glede na odmerek.
However, there was no evidence of any clinical benefit with respect to dyspeptic symptoms.
Niso pa ugotovili klinične koristi, kar zadeva dispeptične simptome.
Concomitant intake of food has no influence on the bioavailability.
Sočasno uživanje hrane ne vpliva na biološko uporabnost.
• Your doctor will adjust the dose depending on your needs and will also decide how long you need to take the medicine for.
• Zdravnik vam bo odmerek prilagodil glede na vaše potrebe in bo tudi odločil, koliko časa morate jemati zdravilo.
This is because Losec can affect the way some medicines work and some medicines can have an effect on Losec.
Zdravilo Losec namreč lahko vpliva na delovanje nekaterih zdravil in nekatera zdravila lahko vplivajo na zdravilo Losec.
Losec may hide the symptoms of other diseases.
Zdravilo Losec lahko prikrije simptome drugih bolezni.
Improperly prepared solutions can be identified by their yellow to brown discolouration and must not be used.
Nepravilno pripravljene raztopine so prepoznavne po rumenem do rjavem obarvanju in se jih ne sme uporabiti.
Hepatitis with or without jaundice
hepatitis z zlatenico ali brez nje
Capsule, hard (capsule).
kapsula, trda (kapsula)
Thus, these changes are not from a direct effect of any individual active substance.
Te spremembe torej niso posledica neposrednega učinka katerekoli zdravilne učinkovine.
The AUC of omeprazole increases with repeated administration.
AUC omeprazola se s ponavljajočo uporabo povečuje.
The majority of patients achieve complete relief of heartburn within 7 days.
Večina bolnikov doseže popolno odpravo zgage v 7 dneh.
The dose for children is based on the child's weight and the doctor will decide the correct dose.
Odmerek za otroka temelji na njegovi telesni masi in ustrezni odmerek bo določil zdravnik.
Frequency categories are defined according to the following convention: Very common (≥ 1/10), Common (≥ 1/100 to < 1/10), Uncommon (≥ 1/1,000 to < 1/100), Rare (≥ 1/10,000 to < 1/1,000), Very rare (< 1/10,000), Not known (cannot be estimated from the available data).
Kategorije pogostnosti so opredeljene po naslednjem dogovoru: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1.000 do < 1/100), redki (≥ 1/10.000 do < 1/1.000), zelo redki (< 1/10.000), ni znano (ni mogoče oceniti na podlagi podatkov, ki so na voljo).
What to do if you or your child have trouble swallowing the capsules
Kaj storiti, če vi ali vaš otrok težko pogoltneta kapsule
Digoxin toxicity has been rarely reported.
Redko je bila opisana toksičnost digoksina.
The safety of omeprazole has been assessed in a total of 310 children aged 0 to 16 years with acid-related disease.
Varnost omeprazola so ocenili pri skupaj 310 otrocih, starih od 0 do 16 let z boleznijo zaradi kisline.
There are no long term data regarding the effects of omeprazole treatment on puberty and growth.
Dolgoročnih podatkov o učinkih zdravljenja z omeprazolom na puberteto in rast ni.
• You lose a lot of weight for no reason and have problems swallowing.
• Brez razloga precej shujšate in imate težave s požiranjem.
After reconstitution the injection should be given slowly over a period of at least 2.5 minutes at a maximum rate of 4 ml per minute.
Po pripravi je treba zdravilo injicirati počasi vsaj 2,5 minute in z največjo hitrostjo 4 ml na minuto.
Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used.
Omeprazol se izloča v materinem mleku, vendar ni verjetno, da bi med uporabo terapevtskih odmerkov vplival na otroka.
During treatment with the recommended doses to children from the age of 1 year, similar plasma concentrations were obtained as compared to adults.
Med uporabo priporočenih odmerkov pri otrocih, starejših od enega leta, je bila koncentracija v plazmi podobna kot pri odraslih.
Pack sizes: • 10 mg:
Velikosti pakiranj: • 10 mg:
Higher daily doses may be required and the dose should be adjusted individually.
Potrebni so lahko večji dnevni odmerki in odmerek je treba prilagoditi vsakemu bolniku posamezno.
If you take Losec on a long-term basis (longer than 1 year) your doctor will probably keep you under regular surveillance.
Če jemljete zdravilo Losec dolgo časa (več kot 1 leto), vas bo zdravnik verjetno redno kontroliral.
Effect on H. pylori
Učinek na H. pylori
The apparent volume of distribution in healthy subjects is approximately 0.3 l/kg body weight.
Navidezni volumen porazdelitve pri zdravih preiskovancih je približno 0,3 l/kg telesne mase.
- Always stir the mixture just before drinking it (the mixture will not be clear).
- Mešanico vedno premešajte, tik preden jo popijete (mešanica ne bo bistra).
Do not be concerned by this list of possible side effects.
Vendar naj vam ta seznam možnih neželenih učinkov ne zbuja skrbi.
The adverse event profile was generally the same as for adults in short- as well as in long-term treatment.
Značilnosti neželenih učinkov so bile na splošno enake kot pri odraslih med kratkotrajnim in dolgotrajnim zdravljenjem.
Repeat steps 1-4 to make sure all omeprazole is transferred from the vial into the infusion bag or bottle.
Ponovite korake od 1 do 4, da boste zagotovili prenos vsega omeprazola iz viale v infuzijsko vrečko ali stekleničko.
Examples of such drugs are R-warfarin and other vitamin K antagonists, cilostazol, diazepam and phenytoin.
Primeri takšnih zdravil so R-varfarin in drugi antagonisti vitamina K, cilostazol, diazepam in fenitoin.
In patients with Zollinger-Ellison syndrome the dose should be individually adjusted and treatment continued as long as clinically indicated.
Bolnikom z Zollinger-Ellisonovim sindromom je treba odmerek prilagoditi individualno, zdravljenje pa nadaljevati, dokler je klinično indicirano.
You should specifically tell your doctor or pharmacist if you are taking clopidogrel (used to prevent blood clots (thrombi)).
Zdravniku ali farmacevtu morate posebej povedati, če jemljete klopidogrel (uporablja se za preprečevanje krvnih strdkov (trombov)).
This medicinal product should not be mixed with other medicinal products than those mentioned in section 6.6.
Zdravila se ne sme mešati z drugimi zdravili razen s tistimi, ki so omenjena v poglavju 6.6. 6.3 Rok uporabnosti
Increasing the atazanavir dose to 400 mg did not compensate for the impact of omeprazole on atazanavir exposure.
Povečanje odmerka atazanavirja na 400 mg ni izravnalo vpliva omeprazola na izpostavljenost atazanavirju.
Vials can however be stored exposed to normal indoor light out side the box for up to 24 hours.
Vendar je mogoče viale do 24 ur shranjevati pri normalni svetlobi v notranjosti prostorov zunaj škatle.
Tell your doctor or pharmacist if you are taking any of the following medicines:
Svojemu zdravniku ali farmacevtu morate povedati, če jemljete katero od naslednjih zdravil:
For patients with swallowing difficulties
Za bolnike, ki imajo težave s požiranjem
• Changes in blood tests that check how the liver is working.
• spremembe izvidov preiskav krvi, ki preverjajo delovanje jeter
• Hair loss (alopecia).
• izpadanje las (alopecija)
• Generally feeling unwell and lacking energy.
• splošno slabo počutje in pomanjkanje energije
Approximately 3% of the Caucasian population and 15-20% of Asian populations lack a functional CYP2C19 enzyme and are called poor metabolisers.
Približno 3 % populacije belcev in od 15 do 20 % azijske populacije nima funkcionalnega encima CYP2C19 in jih imenujemo slabi presnavljalci.
Add the remaining solvent into the vial, make sure the syringe is empty.
Dodajte preostali vehikel v vialo; prepričajte se, da je brizga prazna.
Your doctor will tell you how many tablets to take and how long to take them for.
Zdravnik vam bo povedal, koliko tablet morate vzeti in koliko časa jih morate jemati.
Increased liver enzymes
zvišanje jetrnih encimov
The rate of elimination was unchanged (first order kinetics) with increased doses.
Hitrost odstranjevanja se z naraščanjem odmerkov ni spremenila (kinetika prvega reda).
It is a specific inhibitor of the acid pump in the parietal cell.
Je specifičen zaviralec kislinske črpalke v parietalnih celicah.
• You have severe liver problems.
• Imate hude težave z jetri.
Absorption of omeprazole takes place in the small intestine and is usually completed within 3-6 hours.
Absorpcija omeprazola poteka v tankem črevesu in je po navadi dokončana v 3 do 6 urah.
If symptom control has not been achieved after 2-4 weeks the patient should be investigated further.
Če simptomi po 2 do 4 tednih zdravljenja niso obvladani, bolnik potrebuje nadaljnje preiskave.
Results from three prospective epidemiological studies (more than 1000 exposed outcomes) indicate no adverse effects of omeprazole on pregnancy or on the health of the foetus/newborn child. Omeprazole can be used during pregnancy.
Rezultati treh prospektivnih epidemioloških študij (več kot 1.000 izidov po izpostavljenosti) ne kažejo neželenih učinkov omeprazola na nosečnost ali na zdravje ploda ali novorojenčka.
Increased sweating
močnejše znojenje
When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents.
Zdravljenje razjede na dvanajstniku, ki jo povzroča H. pylori Pri izbiri ustreznega kombiniranega zdravljenja je treba upoštevati uradne nacionalne, regionalne in lokalne smernice o odpornosti bakterij, trajanju zdravljenja (najpogosteje 7 dni, vendar včasih do 14 dni) in ustrezni uporabi protibakterijskih zdravil.
Losec capsules are indicated for:
Kapsule Losec so indicirane za:
Omeprazole is completely metabolised by the cytochrome P450 system (CYP).
Omeprazol se povsem presnovi s sistemom citokroma P450 (CYP).
• They are aged over 55 years with new or recently changed symptoms.
• so starejši od 55 let in se jim pojavijo novi simptomi ali se jim simptomi spremenijo.
Reflux esophagitis: The treatment time is 4-8 weeks.
Refluksni ezofagitis: Trajanje zdravljenja je od 4 do 8 tednov.
To treat ulcers caused by Helicobacter pylori infection and to stop them coming back:
Za zdravljenje razjed, ki jih povzroči okužba s Helicobacter pylori, in za preprečevanje njihovih ponovitev:
• Blood problems such as a reduced number of white cells or platelets.
• krvne motnje, npr. zmanjšanje števila belih krvnih celic ali krvnih ploščic.
Do not take Losec for more than 14 days without consulting a doctor.
Bodite posebno pozorni pri jemanju zdravila Losec Zdravila Losec ne jemljite več kot 14 dni, ne da bi se posvetovali z zdravnikom.
• if you are allergic (hypersensitive) to omeprazole or any of the other ingredients of Losec.
• če ste alergični (preobčutljivi) na omeprazol ali katerokoli sestavino zdravila Losec;
In the literature, doses of up to 560 mg have been described, and occasional reports have been received when single oral doses have reached up to 2,400 mg omeprazole (120 times the usual recommended clinical dose).
V literaturi so bili opisani odmerki do 560 mg in obstajajo občasna poročila o posamičnih odmerkih do 2.400 mg omeprazola (to je 120-kraten običajni priporočeni klinični odmerek).
• The medicine will be given to you as an injection into one of your veins.
• Zdravilo boste dobili kot injekcijo v eno od ven.
In a single-blind study, children aged 0-24 months with clinically diagnosed gastro-esophageal reflux disease were treated with 0.5, 1.0 or 1.5 mg omeprazole/kg.
V enojno slepi študiji so otroke, stare od 0 do 24 mesecev, ki so imeli klinično ugotovljeno gastroezofagealno refluksno bolezen, zdravili z 0,5, 1,0 ali 1,5 mg omeprazola/kg.
• Enlarged breasts in men.
• povečanje prsi pri moških
Omeprazole, a racemic mixture of two enantiomers reduces gastric acid secretion through a highly targeted mechanism of action.
Omeprazol, ki je racemna mešanica dveh enantiomerov, zmanjša izločanje želodčne kisline z zelo usmerjenim mehanizmom delovanja.
It is important not to damage the pellets.
Pomembno je, da se te kroglice ne poškodujejo.
As a precaution, concomitant use of omeprazole and clopidogrel should be discouraged.
Zaradi previdnosti je sočasno uporabo omeprazola in klopidogrela treba odsvetovati.
The pellets release the active ingredient in the intestine, where it is absorbed by your body to give an effect.
Kroglice sprostijo zdravilno učinkovino v črevesu, kjer se absorbira v telo, da učinkuje.
Losec may in very rare cases affect the white blood cells leading to immune deficiency.
Zdravilo Losec lahko v zelo redkih primerih prizadene bele krvne celice in povzroči imunsko pomanjkljivost.
The systemic availability (bioavailability) from a single oral dose of omeprazole is approximately 40%.
Sistemska uporabnost (biološka uporabnost) po enem peroralnem odmerku omeprazola je približno 40 %.
The dry powder in the vial is made into a solution before it is given to you.
Suhi prašek v viali bodo pripravili kot raztopino, preden ga boste dobili.
• Increased sweating.
• močnejše znojenje
Similar findings have been made after treatment with H2-receptor antagonists, proton pump inhibitors and after partial fundectomy.
Podobni so bili izsledki po zdravljenju z antagonisti receptorjev H2, zaviralci protonske črpalke in po delni fundektomiji.
• Children aged over 4 years may take Losec.
• Otroci, stari več kot 4 leta, lahko jemljejo zdravilo Losec.
Concomitant voriconazole treatment resulted in more than doubling of the omeprazole exposure.
Sočasno zdravljenje z vorikonazolom je več kot podvojilo izpostavljenost omeprazolu.
Patients with long-term recurrent symptoms of indigestion or heartburn should see their doctor at regular intervals.
Bolniki, ki imajo dolgotrajne ponavljajoče se simptome težav z želodcem, morajo hoditi na redne preglede k svojemu zdravniku.
All patients with severe disease and inadequate response to other therapies have been effectively controlled and more than 90% of the patients maintained on doses of Losec 20-120 mg daily.
Stanje je bilo učinkovito obvladano pri vseh bolnikih s hudo boleznijo in nezadostnim odzivom na druga zdravljenja; vzdrževalni odmerek je bil pri več kot 90 % bolnikov od 20 do 120 mg zdravila Losec na dan.
The most common side effects (1-10% of patients) are headache, abdominal pain, constipation, diarrhoea, flatulence and nausea/vomiting.
Najpogostejši neželeni učinki (1 do 10 % bolnikov) so glavobol, bolečine v trebuhu, zaprtost, driska, flatulenca in navzea ali bruhanje.
The inhibition of acid secretion is related to the area under the plasma concentration-time curve (AUC) of omeprazole and not to the actual plasma concentration at a given time.
Zavrtje izločanja kisline je povezano s površino pod krivuljo plazemske koncentracije omeprazola po času (AUC) in ne z dejansko koncentracijo v plazmi ob določenem času.
your doctor may also prescribe antibiotics to treat the infection and allow the ulcer to heal.
mu bo zdravnik morda predpisal tudi antibiotike za zdravljenje okužbe in zacelitev razjede.
• You experience severe or persistent diarrhoea, as omeprazole has been associated with a small increase in infectious diarrhoea.
• Če se vam pojavi huda ali dolgotrajna driska, kajti omeprazol je bil povezan z nekoliko večjo pogostnostjo infekcijske driske.
If affected, you should not drive or operate machinery.
Če se vam to zgodi, ne smete voziti ali upravljati s stroji.
• The medicine will be given to you as an infusion into one of your veins.
• Zdravilo boste dobili kot infuzijo v eno od ven.
• In combination with appropriate antibiotics, Helicobacter pylori (H. pylori) eradication in peptic ulcer disease
• v kombinaciji z ustreznimi antibiotiki za odpravo Helicobacter pylori (H. pylori) pri peptični ulkusni bolezni
Elderly The metabolism rate of omeprazole is somewhat reduced in elderly subjects (75-79 years of age).
Starejši Hitrost presnove omeprazola je pri starejših osebah (od 75 do 79 let) nekoliko manjša.
• Ulcers which are infected with bacteria called ‘Helicobacter pylori'.
• Razjed, okuženih z bakterijo, ki se imenuje Helicobacter pylori.
A reinforced monitoring of tacrolimus concentrations as well as renal function (creatinine clearance) should be performed, and dosage of tacrolimus adjusted if needed.
Intenzivneje je treba kontrolirati koncentracijo takrolimusa in delovanje ledvic (očistek kreatinina), odmerek takrolimusa pa prilagoditi, če je treba.
This may cause you symptoms such as a painful burning sensation in the chest rising up to the throat (heartburn) and a sour taste in the mouth (acid regurgitation).
To lahko povzroči simptome, npr. boleč pekoč občutek v prsih, ki se dviga proti žrelu (zgaga) in kisel okus v ustih (regurgitacija kisline).
With a syringe draw 5 ml of infusion solution from the 100 ml infusion bottle or bag.
Z brizgo potegnite 5 ml raztopine za infundiranje iz 100-ml infuzijske stekleničke ali vrečke.
For the eradication of H. pylori the selection of antibiotics should consider the individual patient's drug tolerance, and should be undertaken in accordance with national, regional and local resistance patterns and treatment guidelines.
Za odpravo H. pylori je treba pri izbiri antibiotikov upoštevati prenašanje zdravil pri posameznem bolniku, zdravljenje pa mora upoštevati nacionalne, regionalne in lokalne značilnosti glede odpornosti ter smernice za zdravljenje.
The absorption of posaconazole, erlotinib, ketoconazol and itraconazol is significantly reduced and thus clinical efficacy may be impaired.
Absorpcija posakonazola, erlotiniba, ketokonazola in itrakonazola se bistveno zmanjša in to lahko poslabša klinično učinkovitost.
Detailed information on this product is available on the website of: {name of MS/Agency} [To be completed nationally]
Podrobne informacije o zdravilu so objavljene na spletni strani: {Ime DČ/Agencije} [Izpolni država članica]
What to do if you or your child have trouble swallowing the tablets
Kaj storiti, če vi ali vaš otrok težko pogoltneta tablete
If you have an infection with symptoms such as fever with a severely reduced general condition or fever with symptoms of a local infection such as pain in the neck, throat or mouth or difficulties in urinating, you must consult your doctor as soon as possible so that a lack of white blood cells (agranulocytosis) can be ruled out by a blood test.
Če imate okužbo s simptomi, kot sta npr. zvišana telesna temperatura in zelo slabo splošno stanje, ali zvišana telesna temperatura s simptomi lokalne okužbe, npr. bolečinami v vratu, žrelu ali ustih, ali s težavami pri uriniranju, se morate čim prej posvetovati z zdravnikom, da bo lahko s preiskavo krvi izključil pomanjkanje belih krvnih celic (agranulocitozo).
Omeprazole and omeprazole magnesium are acid labile and are therefore administered orally as enteric-coated granules in capsules or tablets.
Omeprazol in magnezijev omeprazolat sta kislinsko labilna, zato se peroralno uporabljata v gastrorezistentnih zrncih v kapsulah ali tabletah.
Monitoring phenytoin plasma concentration is recommended during the first two weeks after initiating omeprazole treatment and, if a phenytoin dose adjustment is made, monitoring and a further dose adjustment should occur upon ending omeprazole treatment.
Koncentracijo fenitoina v plazmi je priporočljivo kontrolirati prva dva tedna po začetku zdravljenja z omeprazolom; če je narejena prilagoditev odmerka fenitoina, je treba kontrolo in nadaljnjo prilagoditev odmerka narediti po koncu zdravljenja z omeprazolom.
Transfer the solution into the infusion bag or bottle.
Prenesite raztopino v infuzijsko vrečko ali stekleničko.
The remaining part is dependent on another specific isoform, CYP3A4, responsible for the formation of omeprazole sulphone.
Preostali del je odvisen od druge specifične izooblike, CYP3A4; ta je odgovorna za nastanek omeprazolsulfona.
• Your doctor will also prescribe two antibiotics called amoxicillin and clarithromycin for your child.
• Zdravnik bo otroku predpisal tudi dva antibiotika, ki se imenujeta amoksicilin in klaritromicin.
Children and adolescents over 4 years of age • In combination with antibiotics in treatment of duodenal ulcer caused by H. pylori
Otroci in mladostniki, starejši od 4 let • v kombinaciji z antibiotiki za zdravljenje razjede na dvanajstniku, ki jo povzroča H. pylori
If you do not experience relief, or if you experience a worsening of symptoms, consult your doctor.
Če se vam stanje ne izboljša ali če se vam simptomi poslabšajo, se posvetujte z zdravnikom.
The symptoms described in connection to omeprazole overdose have been transient, and no serious outcome has been reported.
Simptomi, opisani v povezavi s prevelikim odmerjanjem omeprazola, so bili prehodni in poročali niso o nobenem resnem izidu.
Chemical and physical in-use stability has been demonstrated for 4 hours at 25oC after reconstitution.
Kemična in fizikalna stabilnost med uporabo sta bili dokazani za 4 ure po pripravi (rekonstituciji) pri temperaturi 25 °C.
The pharmacokinetics of omeprazole, including systemic bioavailability and elimination rate, are unchanged in patients with reduced renal function.
Farmakokinetika omeprazola, vključno s sistemsko biološko uporabnostjo in hitrostjo odstranjevanja, pri bolnikih z zmanjšanim delovanjem ledvic ni spremenjena.
• Eyesight problems such as blurred vision.
• težave z vidom, npr. zamegljen vid
In addition, omeprazole lacks an inhibitory effect on the main CYP enzymes.
Poleg tega omeprazol ne zavira glavnih encimov CYP.
If your doctor has prescribed the antibiotics amoxicillin and clarithromycin as well as Losec to treat ulcers caused by Helicobacter pylori infection, it is very important that you tell your doctor about any other medicines you are taking.
Če vam je zdravnik poleg zdravila Losec za zdravljenje razjed, ki jih povzroča okužba s Helicobacter pylori, predpisal tudi antibiotika amoksicilin in klaritromicin, je zelo pomembno, da mu poveste za vsa druga zdravila, ki jih morda jemljete.
• Diazepam (used to treat anxiety, relax muscles or in epilepsy).
• diazepam (uporablja se za zdravljenje tesnobnosti, za sproščanje mišic ali pri epilepsiji).
The major part of its metabolism is dependent on the polymorphically expressed CYP2C19, responsible for the formation of hydroxyomeprazole, the major metabolite in plasma.
Glavni del njegove presnove je odvisen od polimorfno izraženega CYP2C19; ta je odgovoren za nastanek hidroksiomeprazola, glavnega presnovka v plazmi.
• Losec will be given to you by a doctor who will decide how much you need.
• Zdravilo Losec vam bo dal zdravnik, ki bo tudi odločil, koliko zdravila potrebujete.
In such individuals the metabolism of omeprazole is probably mainly catalysed by CYP3A4.
Pri takšnih osebah presnovo omeprazola verjetno v glavnem katalizira CYP3A4.