natgillin/translations-raw huggingface dataset:
As a fluoroquinolone antibacterial agent, levofloxacin acts on the DNA-DNA-gyrase complex and topoisomerase IV.
Kot fluorokinolonsko protibakterijsko zdravilo deluje levofloksacin na DNA-DNA-girazni kompleks in na topoizomerazo IV.
• You have ever had heart problems: caution should be taken when using this kind of medicine, if you were born with or have family history of prolonged QT interval (seen on ECG, electrical recording of the heart), have salt imbalance in the blood (especially low level of potassium or magnesium in the blood), have a very slow heart rhythm (called ‘bradycardia'), have a weak heart (heart failure),
• Ste kdajkoli imeli težave s srcem: pri jemanju zdravil te vrste je potrebna previdnost, če imate podaljšan interval QT - prirojeno ali v družinski anamnezi (vidno z EKG, električni zapis delovanja srca), če imate porušeno ravnovesje soli v krvi (predvsem nizka raven kalija ali magnezija v krvi), zelo počasen srčni ritem (t. i. ‘bradikardijo‘), če imate oslabelo srce (srčno popuščanje), ste imeli srčni infarkt (miokardni infarkt), ste ženska ali starejša oseba ali če jemljete druga zdravila, ki povzročajo neobičajne spremembe v EKG (glejte poglavje Druga zdravila in zdravilo Tavanic)
then: 125 mg/48 h then: 125 mg/24 h then: 125 mg/24 h
potem: 125 mg/48 ur potem: 125 mg/24 ur potem: 125 mg/24 ur
• Inflammation of the tissue inside the mouth (stomatitis)
• Vnetje tkiva v ustih (stomatitis)
All patients should consult their physician if they experience symptoms of tendinitis.
Vsi bolniki, ki doživijo simptome tendinitisa, se morajo posvetovati z zdravnikom.
Tendinitis and tendon rupture, sometimes bilateral, may occur within 48 hours of starting treatment with levofloxacin and have been reported up to several months after discontinuation of treatment.
Tendinitis in pretrganje tetive, včasih obojestransko, se lahko pojavi v 48 urah po začetku zdravljenja z levofloksacinom.
This includes medicines used for abnormal heart rhythm (antiarrhythmics such as quinidine, hydroquinidine, disopyramide, sotalol, dofetilide, ibutilide and amiodarone), for depression (tricyclic antidepressants such as amitriptyline and imipramine,), for psychiatric disorders (antipsychotics), and for bacterial infections (‘macrolide' antibiotics such as erythromycin, azithromycin and clarithromycin)
To so zdravila za zdravljenje neenakomernega bitja srca (antiaritmiki kot so kinidin, hidrokinidin, disopiramid, sotalol, dofetilid, ibutilid in amiodaron), depresij (triciklični antidepresivi kot sta amitriptilin in imipramin), psihiatričnih motenj (antipsihotiki) in bakterijskih okužb (makrolidni antibiotiki kot so eritromicin, azitromicin, klaritromicin).
Pain (including pain in back, chest, and extremities)
Bolečine (vključno z bolečinami v hrbtu, v prsih in okončinah)
Staphylococcus aureus methicillin-resistant#
Staphylococcus aureus, odporen proti meticilinu#
Cases of hypoglycaemic coma have been reported.
Poročali so o primerih hipoglikemične kome.
Tavanic is contraindicated in children and growing adolescents (see section 4.3).
Zdravilo Tavanic je kontraindicirano pri otrocih in odraščajočih mladostnikih (glejte poglavje 4.3).
Clinical pharmacology studies have shown that the pharmacokinetics of levofloxacin were not affected to any clinically relevant extent when levofloxacin was administered together with the following drugs: calcium carbonate, digoxin, glibenclamide, ranitidine.
Klinično-farmakološke raziskave so pokazale, da na farmakokinetiko levofloksacina ni klinično pomembno vplivala hkratna uporaba z nobenim od naslednjih učinkovin: kalcijevim karbonatom, digoksinom, glibenklamidom, ranitidinom.
• Severe skin rashes which may include blistering or peeling of the skin around your lips, eyes, mouth, nose and genitals
• Hud izpuščaj na koži, ki lahko obsega nastanek mehurjev ali lupljenje kože okrog ustnic, oči, ust, nosu in spolovil.
Levofloxacin is contraindicated in patients with a history of epilepsy (see section 4.3) and, as with other quinolones, should be used with extreme caution in patients predisposed to seizures or concomitant treatment with active substances that lower the cerebral seizure threshold, such as theophylline (see section 4.5).
Levofloksacin je kontraindiciran pri bolnikih z anamnezo epilepsije (glejte poglavje 4.3) in ga moramo tako kot druge kinolone izredno previdno uporabljati pri bolnikih z nagnjenostjo h konvulzivnim napadom ali pri bolnikih, ki se hkrati zdravijo z učinkovinami, ki znižujejo cerebralni prag za konvulzije, kakršno je npr. teofilin (glejte poglavje 4.5).
a Anaphylactic and anaphylactoid reactions may sometimes occur even after the first dose b Mucocutaneous reactions may sometimes occur even after the first dose
b Mukokutane reakcije se včasih lahko pojavijo že po prvem odmerku.
• Muscle rupture and muscle destruction (rhabdomyolysis)
• Pretrganje mišic in razpad mišičnih vlaken (rabdomioliza)
No adjustment of dose is required in the elderly, other than that imposed by consideration of renal function (see section 4.4 “Tendinitis and tendon rupture” and “QT interval prolongation”).
Pri starejših je treba odmerek prilagoditi le v primeru spremenjenega delovanja ledvic (glejte poglavje 4.4 »Tendinitis in pretrganje tetive« in »Podaljšanje intervala QT«).
If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Tavanic.
Če niste prepričani, da karkoli od zgoraj navedenega velja za vas, se o tem posvetujte z zdravnikom ali s farmacevtom, preden vzamete zdravilo Tavanic.
What Tavanic tablets look like and contents of the pack Tavanic tablets are film-coated tablets for oral use.
Izgled zdravila Tavanic in vsebina pakiranja Zdravilo Tavanic tablete so filmsko obložene tablete namenjene peroralni rabi.
In very rare cases these have progressed to suicidal thoughts and self-endangering behaviour- sometimes after only a single dose of levofloxacin (see section 4.8).
V zelo redkih primerih so se psihotične reakcije stopnjevale vse do pojava samoogrožajočega vedenja in samomorilnih misli - včasih tudi po samo enkratnem odmerku levofloksacina (glejte poglavje 4.8).
Psychotic disorders with self-endangering behaviour including suicidal ideation or suicide attempt (see section 4.4)
Psihotične reakcije z ogrožanjem lastne varnosti, vključno s samomorilnimi mislimi ali dejanji (glejte poglavje 4.4)
The half-life of ciclosporin was increased by 33% when coadministered with levofloxacin.
Razpolovni čas ciklosporina se je med sočasno uporabo levofloksacina podaljšal za 33 %.
According to toxicity studies in animals or clinical pharmacology studies performed with supra-therapeutic doses, the most important signs to be expected following acute overdose of Tavanic tablets are central nervous system symptoms such as confusion, dizziness, impairment of consciousness, and convulsive seizures, increases in QT interval as well as gastro-intestinal reactions such as nausea and mucosal erosions.
Glede na študije toksičnosti na živalih oz. klinično farmakološke študije s supraterapevtskimi odmerki so najpomembnejši znaki, ki jih je mogoče pričakovati po akutnem prevelikem odmerjanju tablet Tavanic, simptomi s strani osrednjega živčevja, npr. zmedenost, omotica, motnje zavesti in konvulzivni napadi, podaljšanje intervala QT in gastrointestinalne reakcije, npr. navzeja in erozije sluznice.
There are no major differences in the pharmacokinetics of levofloxacin following intravenous and oral administration, suggesting that the oral and intravenous routes are interchangeable.
Farmakokinetika levofloksacina se po intravenski in peroralni uporabi ne razlikuje pomembno, kar kaže, da sta peroralna in intravenska pot izmenljivi.
• For the tablet coating: hypromellose, titanium dioxide (E 171), talc, macrogol, yellow ferric oxide
• Obloga tablete: hipromeloza, titanov dioksid (E 171), smukec, makrogol, rumeni železov oksid
The bioavailability of Tavanic tablets is significantly reduced when administered together with sucralfate.
Biološka uporabnost zdravila Tavanic tablete se ob zaužitju s sukralfatom značilno zmanjša.
Fluoroquinolones, including levofloxacin, have neuromuscular blocking activity and may exacerbate muscle weakness in patients with myasthenia gravis.
Fluorokinoloni, vključno z levofloksacinom, blokirajo živčno-mišične povezave in pri bolnikih z miastenijo gravis lahko poslabšajo šibkost mišic.
Tavanic may also be used to complete a course of therapy in patients who have shown improvement during initial treatment with intravenous levofloxacin.
Zdravilo Tavanic se lahko uporabi za dokončanje zdravljenja pri bolnikih, pri katerih je bil v začetnem obdobju zdravljenja z intravenozno obliko levofloksacina dosežen napredek.
Patients treated with Vitamin K antagonists
Bolniki, zdravljeni z antagonisti vitamina K
Therefore, if levofloxacin has to be used in these patients, potential occurrence of haemolysis should be monitored.
Če morajo taki bolniki jemati levofloksacin, je treba pri njih nadzorovati možnost pojava hemolize.
In diabetic patients, careful monitoring of blood glucose is recommended (see section 4.8).
Pri sladkornih bolnikih je priporočljivo redno spremljati vrednosti glukoze v krvi (glejte poglavje 4.8).
If the patient is to receive both sucralfate and Tavanic, it is best to administer sucralfate 2 hours after the Tavanic tablet administration (see section 4.2).
Če mora bolnik dobiti sukralfat in zdravilo Tavanic, je najbolje, da sukralfat vzame 2 uri po zaužitju tablet zdravila Tavanic (glejte poglavje 4.2).
If CDAD is suspected or confirmed, levofloxacin should be stopped immediately and appropriate treatment initiated without delay.
Če obstaja sum na CDAD ali je ta diagnoza potrjena, je treba uporabo levofloksacina takoj prekiniti, bolniku pa brez odlašanja uvesti primerno zdravljenje.
Other medicines and Tavanic
Druga zdravila in zdravilo Tavanic
Levofloxacin has been shown to penetrate into bronchial mucosa, epithelial lining fluid, alveolar macrophages, lung tissue, skin (blister fluid), prostatic tissue and urine.
Dokazano je, da levofloksacin prodira v bronhialno sluznico, epitelijsko tekočino, alveolarne makrofage, pljuča, kožo (vodeni mehur), prostato in v urin.
As for all medicines, any unused medicinal product should be disposed of accordingly and in compliance with local environmental regulations.
Neuporabljeno zdravilo zavrzite v skladu z lokalnimi predpisi.
In common with other fluoroquinolones, levofloxacin showed effects on cartilage (blistering and cavities) in rats and dogs.
Tako kot drugi fluorokinoloni tudi levofloksacin vpliva na hrustanec (povzroča mehurje in votline)pri podganah in psih.
• Feeling stressed (anxiety), feeling confused, feeling nervous, feeling sleepy, trembling, a spinning feeling (vertigo)
• Občutek stresa (tesnobe), zmedenost, nervoza, zaspanost, tresavica, vrtoglavica (vertigo)
If you accidentally take more tablets than you should, tell a doctor or get other medical advice straight away.
Če ste vzeli večji odmerek zdravila Tavanic tablete, kot bi smeli Če ste pomotoma zaužili več tablet, kot bi jih smeli, to takoj povejte zdravniku ali poiščite zdravniško pomoč.
Ventricular tachycardia, which may result in cardiac arrest
Tahikardija, palpitacije Ventrikularna tahikardija, ki lahko privede do srčnega zastoja
Blood creatinine increased
Povečanje vrednosti kreatinina v krvi
• Watery diarrhoea which may have blood in it, possibly with stomach cramps and a high temperature.
• Vodena driska, v kateri je lahko kri; spremljajo jo lahko krči v trebuhu in zvišana telesna temperatura.
However, levofloxacin has poor penetration intro cerebro-spinal fluid.
Levofloksacin slabo prodira v cerebrospinalno tekočino (likvor).
Antacids may be used for protection of gastric mucosa.
Za zaščito želodčne sluznice je mogoče uporabiti antacide.
Levofloxacin obeys linear pharmacokinetics over a range of 50 to 1000 mg.
Farmakokinetika levofloksacina je v območju od 50 do 1.000 mg linearna.
Jaundice and severe liver injury, including cases with fatal acute liver failure, primarily in patients with severe underlying diseases (see section 4.4) Hepatitis
Zlatenica in hude poškodbe jeter, vključno z usodnimi primeri z akutno odpovedjo jeter, v glavnem pri bolnikih z resnimi primarnimi obolenji (glejte poglavje 4.4) Hepatitis
Calcium salts have a minimal effect on the oral absorption of levofloxacin.
Kalcijeve soli imajo minimalen učinek na peroralno absorbcijo levfloksacina.
• Non-steroidal anti-inflammatory drugs (NSAIDS) - used for pain and inflammation such as aspirin, ibuprofen, fenbufen, ketoprofen and indomethacin.
• Nesteroidni antirevmatiki (NSAID), ki se uporabljajo za zdravljenje bolečine ali vnetja, npr. acetilsalicilna kislina, ibuprofen, fenbufen, ketoprofen, indometacin.
Penetration into tissues and body fluids
Prodiranje v tkiva in telesne tekočine:
These SmPCs, labelling and packages leaflets are the version valid at the time of Commission decision.
Navedena verzija povzetkov glavnih značilnosti zdravila, označevanja in navodil za uporabo je veljavna za časa izdaje Odločbe Evropske komisije.
Drugs known to prolong QT interval
Zdravila, za katera je znano, da podaljšujejo interval QT
EUCAST clinical MIC breakpoints for levofloxacin (version 2.0, 2012-01-01):
Klinični mejni vrednosti minimalne inhibitorne koncentracije (MIK) za levofloksacin po EUCAST-u (verzija 2.0, 1.1.2012):
Complicated skin and soft tissue infections
• Zapletene okužbe kože in mehkih tkiv
• Itching and skin rash, severe itching or hives (urticaria), sweating too much (hyperhidrosis)
• Srbenje in izpuščaj na koži, hudo srbenje ali koprivnica (urtikarija), obilno znojenje (hiperhidroza)
• You have ever had liver problems
• Ste kdaj imeli težave z jetri
1 film-coated tablet 3 film-coated tablets 5 film-coated tablets 7 film-coated tablets 10 film-coated tablets 50 film-coated tablets 200 film-coated tablets
1 filmsko obložena tableta 3 filmsko obložene tablete 5 filmsko obloženih tablet 7 filmsko obloženih tablet 10 filmsko obloženih tablet 50 filmsko obloženih tablet 200 filmsko obloženih tablet
Tendinitis and tendon rupture
Tendinitis in pretrganje tetive
For 500 mg tablet:
500 mg tablete:
Levofloxacin can cause serious, potentially fatal hypersensitivity reactions (e.g. angioedema up to anaphylactic shock), occasionally following the initial dose (see section 4.8).
Levofloksacin lahko povzroči resne, tudi smrtno nevarne preobčutljivostne reakcije (npr. od angioedema, pa vse do anafilaktičnega šoka), ki se občasno pojavijo po začetnem odmerku (glejte poglavje 4.8).
• Iron tablets (for anemia), zinc supplements, magnesium or aluminum-containing antacids (for acid or heartburn), didanosine, or sucralfate (for stomach ulcers).
• Tablete z železom (za anemijo), cinkovi dodatki, antacidi ki vsebujejo magnezij ali aluminij (za želodčno kislino ali zgago), didanozin ali sukralfat (za želodčni ulkus).
The Achilles tendon is affected most often
Najpogosteje je prizadeta Ahilova kita
Orally administered levofloxacin is rapidly and almost completely absorbed with peak plasma concentrations being obtained within 1 - 2 h. The absolute bioavailability is 99 - 100%.
Peroralno uporabljeni levofloksacin se hitro in skoraj popolnoma absorbira; vrh koncentracije v plazmi doseže v 1 - 2 urah.
Summary of product characteristics, labelling and package leaflets
Priloga III Povzetek glavnih značilnosti zdravila, označevanje in navodilo za uporabo
You are more likely to have a fit (seizure) if taken with Tavanic
Bolj verjetno je, da boste imeli več napadov (krčev), če jemljete to zdravilo z zdravilom Tavanic.
Levofloxacin caused no impairment of fertility or reproductive performance in rats.
Levofloksacin pri podganah ni povzročal okvar plodnosti ali sposobnosti reprodukcije.
Methicillin-resistant S. aureus are very likely to possess co-resistance to fluoroquinolones, including levofloxacin.
Proti meticilinu odporen S. aureus je zelo verjetno odporen tudi na fluorokinolone, vključno z levofloksacinom.
• Problems moving and walking (dyskinesia, extrapyramidal disorders)
• Težave z gibanjem in hojo (diskinezija, ekstrapiramidne motnje)
• Lowering of your blood sugar levels (hypoglycaemia).
• Znižanje koncentracije krvnega sladkorja (hipoglikemija).
Hearing loss Hearing impaired
Izguba sluha Okvara sluha
Caution should be exercised when levofloxacin is coadministered with drugs that affect the tubular renal secretion such as probenecid and cimetidine, especially in renally impaired patients.
Previdnost je potrebna pri sočasni uporabi levofloksacina in učinkovin, ki vplivajo na sekrecijo v ledvičnih tubulih, npr. probenecida in cimetidina, še posebej pri bolnikih z okvaro ledvic.
Chronic bacterial prostatitis
• Kronični bakterijski prostatitis
For 250 mg tablet:
250 mg tablete:
500 mg once or twice daily
500 mg enkrat ali dvakrat/dan
Effect of Tavanic on other medicinal products
Učinek zdravila Tavanic na delovanje drugih zdravil
• You are using corticosteroids, sometimes called steroids (see section “Other medicines and
• Jemljete kortikosteroide oz. steroide (glejte tudi »Druga zdravila in zdravilo Tavanic«)
In particular, tell your doctor if you are taking any of the following medicines.
Povejte zdravniku, če jemljete katero od spodaj navedenih zdravil.
• Probenecid - used for gout and cimetidine - used for ulcers and heartburn.
• Probenicid - za zdravljenje protina in cimetidin - za zdravljenje ulkusa in zgage.
Levofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong the QT interval (e.g. Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics) (see section 4.4 QT interval prolongation).
Tako kot druge fluorokinolone je treba tudi levofloksacin uporabljati previdno pri bolnikih, ki dobivajo zdravila, za katera je znano, da podaljšujejo interval QT (npr. antiaritmike iz skupine IA in skupine III, triciklične antidepresive, makrolide, antipsihotike) (glejte poglavje 4.4 Podaljšanje intervala QT).
They may be divided at the score line to adapt the dose.
Za prilagoditev odmerka jih je mogoče prelomiti po zarezani črti.
Complicated urinary tract infections 500 mg once daily
7-10 dni zapletene okužbe urinarnega trakta 500 mg enkrat/dan
Photosensitisation has been reported with levofloxacin (see section 4.8).
Pri levofloksacinu so poročali o fotosenzibilizaciji (glejte poglavje 4.8).
A tendon is the cord that joins your muscle to your skeleton
Tetiva je vez, ki pritrjuje mišico na kost.
Acute bacterial exacerbations of chronic bronchitis
• Akutna poslabšanja kroničnega bakterijskega bronhitisa
• Changes in the way things taste, loss of appetite, stomach upset or indigestion (dyspepsia), pain in your stomach area, feeling bloated (flatulence) or constipation
• Sprememba okusa, izguba teka, razdražen želodec ali težave z želodcem (dispepsija), bolečine v predelu trebuha, občutek napihnjenosti (flatulenca) ali zaprtje
Iron salts, zinc salts, magnesium- or aluminium-containing antacids, didanosine
Soli železa, soli cinka, antacidi z magnezijem ali aluminijem, didanozin
Inhalation Anthrax: postexposure prophylaxis and curative treatment (see section 4.4)
• Inhalacijski antraks: poekspozicijska profilaksa (PEP) in zdravljenje (glejte poglavje 4.4).
1 film-coated tablet 5 film-coated tablets 7 film-coated tablets 10 film-coated tablets 50 film-coated tablets 200 film-coated tablets 500 film-coated tablets
1 filmsko obložena tableta 5 filmsko obloženih tablet 7 filmsko obloženih tablet 10 filmsko obloženih tablet 50 filmsko obloženih tablet 200 filmsko obloženih tablet 500 filmsko obloženih tablet
Tavanic 500 mg tablets levofloxacin
Tavanic 500 mg tablete levofloksacin
Do not use this medicine after the expiry date which is stated on the carton and foil after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti (EXP), ki je naveden na ovojnini poleg oznake EXP. Datum izteka roka uporabnosti se nanaša na zadnji dan navedenega meseca.
Since levofloxacin is excreted mainly by the kidneys, the dose of Tavanic should be adjusted in patients with renal impairment (see section 4.2).
Ker se levofloksacin izloča predvsem skozi ledvice, je treba pri bolnikih z okvaro ledvic odmerek zdravila Tavanic prilagoditi (glejte poglavje 4.2).
Anaerobic bacteria Peptostreptococcus
Providencia rettgeri anaerobne bakterije Peptostreptococcus druge
• Muscle weakness.
• Šibkost mišic.
• Problems with your hearing (tinnitus) or eyesight (blurred vision)
• Težave s sluhom (tinitus) ali vidom (zamegljen vid)
1No additional doses are required after haemodialysis or continuous ambulatory peritoneal dialysis (CAPD).
1 Po hemodializi ali nepretrgani ambulantni peritonealni dializi (CAPD) niso potrebni dodatni odmerki.
Coagulation tests, therefore, should be monitored in patients treated with vitamin K antagonists (see section 4.4).
Pri bolnikih, ki dobivajo antagoniste vitamina K, je zato treba nadzirati koagulacijske teste (glejte poglavje 4.4).
Staphylococcus aureus methicillin-susceptible Staphylococcus saprophyticus Streptococci, group C and G Streptococcus agalactiae Streptococcus pneumoniae Streptococcus pyogenes
Staphylococcus aureus, občutljiv za meticilin Staphylococcus saprophyticus Streptokoki, skupina C in G Streptococcus agalactiae Streptococcus pneumoniae Streptococcus pyogenes aerobne po Gramu-negative bakterije Eikenella corrodens Haemophilus influenzae Haemophilus para-influenzae Klebsiella oxytoca
• Inflammation of the liver (hepatitis)
• Vnetje jeter (hepatitis)
• For the tablet core: crospovidone, hypromellose, microcrystalline cellulose and sodium stearyl fumarate
• Jedro tablete: krospovidon, hipromeloza, mikrokristalna celuloza, natrijev stearilfumarat
What Tavanic tablets are and what they are used for 2.
Kaj je zdravilo Tavanic tablete in za kaj ga uporabljamo
Keep out of direct sunlight while taking this medicine and for 2 days after you stop taking it.
Med jemanjem tega zdravila in 2 dni po prenehanju jemanja zdravila se ne izpostavljajte direktni sončni svetlobi.
Special populations Impaired renal function (creatinine clearance 50 ml/min)
Okvarjeno delovanje ledvic (očistek kreatinina (≤ 50 ml/min)
Resistance to levofloxacin is acquired through a stepwise process by target site mutations in both type II topoisomerases, DNA gyrase and topoisomerase IV. Other resistance mechanisms such as permeation barriers (common in Pseudomonas aeruginosa) and efflux mechanisms may also affect susceptibility to levofloxacin.
Odpornost proti levofloksacinu se razvije v stopenjskem procesu in sicer s ciljanimi mutacijami v obeh topoizomerazah tipa II, DNK girazi in v topoizomerazi IV. Na občutljivost na levofloksacin lahko vplivajo tudi drugi mehanizmi odpornosti, kot so neprepustnost oz. zmanjšana prepustnost celične membrane za antibiotik (pogosta pri Pseudomonas aeruginosa) in aktivno izčrpavanje antibiotika iz bakterijske celice z aktivnim transportom.
Chlamydophila pneumoniae Chlamydophila psittaci Chlamydia trachomatis
Chlamydophila pneumoniae Chlamydophila psittaci Chlamydia trachomatis legionella pneumophila Mycoplasma pneumoniae Mycoplasma hominis Ureaplasma urealyticum
• The dose will depend on the type of infection you have and where the infection is in your body.
• Odmerek je odvisen od vrste in lokacije okužbe
INSTRUCTIONS ON USE [To be completed nationally]
NAVODILA ZA UPORABO [izpolni država članica]
In the absence of human data and due to that experimental data suggest a risk of damage by fluoroquinolones to the weight-bearing cartilage of the growing organism, levofloxacin must not be used in breast-feeding women (see sections 4.3 and 5.3).
Ker ni podatkov pri človeku in ker je eksperimentalno ugotovljeno tveganje, da fluorokinoloni poškodujejosklepni hrustanec, doječe ženske ne smejo uporabljati zdravila Tavanic tablete (glejte poglavji 4.3 in 5.3).
Take your dose of these medicines at least 2 hours before or after Tavanic tablets.
2 uri pred ali po zaužitju zdravila Tavanic tablete.
Do not double-up the next dose to make up for the missed dose.
Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
Highlighted in grey: Applies to 250 mg tablet strength only
Obarvano sivo: Nanaša se le na 250 mg jakost