natgillin/translations-raw huggingface dataset:
Other uncommon side effects (may affect up to 1 in 100 people) may include decreased appetite (anorexia), agitation, irritability, hair loss, hives, skin odour abnormal, lack of control over passing urine (urinary incontinence).
Drugi občasni neželeni učinki (pojavijo se lahko pri 1 od 100 bolnikov) lahko vključujejo zmanjšanje apetita (anoreksijo), vznemirjenost, razdražljivost, izpadanje las, koprivnico, nenavaden vonj kože, nesposobnost nadziranja urina (urinska inkontinenca).
It is converted into homocysteine which is then normally converted into cysteine during digestion.
Spremeni se v homocistein, ta pa nato med prebavo normalno naprej v cistein.
The most commonly reported adverse reaction during treatment is blood methionine increased.
Neželeni učinek, o katerem so med zdravljenjem poročali najpogosteje, je povečanje metionina v krvi.
In observational studies, clinical improvement (cardiovascular and neurodevelopmental) was reported by the treating physician in about 75% of patients taking betaine anhydrous.
Pri opazovalnih študijah je lečeči zdravnik poročal o kliničnem izboljšanju (tako kardiovaskularnem kot glede razvoja živčevja) pri okrog 75 % bolnikov, ki so jemali brezvodni betain.
This demonstrates that differences in betaine anhydrous kinetics are most probably due to betaine anhydrous depletion in untreated homocystinuria and are only meaningful for the initial treatment.
To kaže, da so razlike v kinetiki brezvodnega betaina najverjetneje posledica izčrpanja brezvodnega betaina pri nezdravljeni homocistinuriji in so pomembne samo za začetno zdravljenje.
What you need to know before you take Cystadane
Kaj morate vedeti, preden boste vzeli zdravilo Cystadane
Complete recovery was seen after treatment discontinuation: - The plasma methionine concentrations should be kept below 1000 µM.
Po prekinitvi zdravljenja so bolniki popolnoma okrevali: - Koncentracija metionina v plazmi mora biti nižja od 1000 µM.
During pregnancy, administering betaine anhydrous in addition to pyridoxine, folate, anticoagulant and diet under close monitoring of plasma homocysteine would be compatible with good maternal and foetal outcomes.
V nosečnosti bi bila uporaba brezvodnega betaina kot dodatek piridoksinu, folatu, antikoagulantu in dieti ob pazljivem spremljanju homocisteina v plazmi združljiva z ugodnim izidom za mater in plod.
It is likely that due to the multiple nature of therapy (dietary, pharmaceutical, supportive) in these patients, there may be an element of overestimation in the clinical effects of betaine anhydrous treatment.
Pri teh bolnikih zaradi večtirnosti zdravljenja (zdravljenje z dieto, z zdravili, podporno zdravljenje) verjetno obstaja element precenjevanja kliničnih učinkov zdravljenja z brezvodnim betainom.
5 How to store Cystadane Contents of the pack and other information
5 Shranjevanje zdravila Cystadane Vsebina pakiranja in dodatne informacije
If you experience morning headaches with vomiting and/or visual changes, contact immediately your doctor (they could be signs of a swelling in the brain).
Če opazite jutranji glavobol z bruhanjem in/ali spremembami vida, se takoj posvetujte s svojim zdravnikom (to lahko so znaki otekline možganov).
The recommended total daily dose is 100 mg/kg/day given in 2 doses daily.
Priporočeni celotni dnevni odmerek je 100 mg/kg/dan, ki se daje v 2 dnevnih odmerkih.
(age between 21 to 49 years), after a single oral dose of betaine anhydrous (50 mg/kg), absorption was rapid (tmax = 0.9 ± 0.3 hours and a Cmax = 0.9 ± 0.2 mM).
Pri zdravih odraslih prostovoljcih (starih med 21 in 49 leti) je bila po enkratnem peroralnem odmerku brezvodnega betaina (50 mg/kg) absorpcija hitra (tmax = 0,9 ± 0,3 ure in Cmax = 0,9 ± 0,2 mM).
The powder should be mixed with water, juice, milk, formula or food until completely dissolved and ingested immediately after mixing.
Prašek je treba zmešati z vodo, sadnim sokom, mlekom, formulo ali hrano, da se popolnoma raztopi in ga po mešanju takoj zaužiti.
What Cystadane is and what it is used for What do you need to know before you take Cystadane How to take Cystadane
Kaj je zdravilo Cystadane in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Cystadane Kako jemati zdravilo Cystadane Možni neželeni učinki
The recommended dose in children and adults is 100mg/kg/day divided in 2 dosesper day.
Priporočeni odmerek pri otrocih in odraslih je 100 mg/kg/dan, razdeljen na 2 odmerka.
Uncommon: agitation, irritability
Občasne: agitiranost, razdražljivost
Do not use this medicine after the expiry date which is stated on the bottle label and the carton after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na ovojnini steklenice in škatli poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
It is not known whether betaine anhydrous is excreted in human milk (although its metabolic precursor, choline, occurs at high levels in human milk).
Ni znano, ali se brezvodni betain izloča v materino mleko (čeprav se njegov presnovni prekurzor, holin, v materinem mleku pojavlja v visokih koncentracijah).
Methionine level can be related to swelling in the brain (cerebral swelling), which may affect up to 1 in 100 people (frequency uncommon).
Raven metionina je lahko povezana z oteklino možganov (cerebralna oteklina), ki se lahko pojavi pri 1 od 100 bolnikov (občasna pogostnost).
Most of these patients were also receiving other treatments such as vitamin B6 (pyridoxine), vitamin B12 (cobalamin) and folate with variable biochemical responses.
Večina teh bolnikov je prejemala tudi druga zdravila, na primer vitamin B6 (piridoksin), vitamin B12 (kobalamin) in folat, z variabilnimi biokemičnimi odzivi.
- If symptoms of cerebral oedema recur after re-introduction of treatment then betaine anhydrous therapy should be discontinued indefinitely.
- Če se po ponovni uvedbi zdravljenja simptomi možganskega edema spet pojavijo, je treba zdravljenje z brezvodnim betainom za vedno opustiti.
If you stop taking Cystadane
Če ste prenehali jemati zdravilo Cystadane
Cystadane contains betaine anhydrous which is intended to be an adjunctive treatment of homocystinuria, an inherited (genetic) disease where the amino acid methionine cannot be broken down completely by the body.
Zdravilo Cystadane vsebuje brezvodni betain, ki je namenjen dodatnemu zdravljenju homocistinurije, podedovane (genetske) bolezni, pri kateri telo ne more razgraditi aminokisline metionina.
180 g of oral powder.
180 g peroralnega praška.
Mix the measured dose of powder with water, juice, milk, formula or food until completely dissolved and ingest immediately after mixing.
Zmešajte izmerjen odmerek praška z vodo, sadnim sokom, mlekom, formulo ali hrano, da se bo popolnoma raztopil, in ga po mešanju takoj zaužijte.
Cystadane has no or negligible influence on the ability to drive and use machines.
Zdravilo Cystadane nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
To minimise the risk of potential drug interactions, it is advisable to leave 30 minutes between the intake of betaine anhydrous and amino acids mixtures and/or medicinal products containing vigabatrin and GABA analogues (see section 4.5).
Da se nevarnost možnih interakcij med zdravili čim bolj zmanjša, priporočamo, naj med zaužitjem brezvodnega betaina in mešanic aminokislin ali zdravil, ki vsebujejo vigabatrin in analoge GABA ali obojega, mine 30 minut (glejte poglavje 4.5).
Do not take Cystadane If you are allergic to betaine anhydrous.
Ne jemljite zdravila Cystadane če ste vi ali vaš otrok alergični na brezvodni betain.
If you are treated with Cystadane and with an amino-acid mixture and if you need to take other medicines at the same time, leave 30 minutes between the intake (see “section “Other medicines and Cystadane”).
Če se zdravite z zdravilom Cystadane in z mešanico aminokislin in morate istočasno jemati še druga zdravila, druga zdravila vzemite šele pol ure ali več po tistem, ko vzamete Cystadane in mešanico aminokislin (glejte poglavje »Druga zdravila in zdravilo Cystadane«).
Because of lack of data, caution should be exercised when prescribing Cystadane to breast-feeding women.
Zaradi pomanjkanja podatkov je pri predpisovanju zdravila Cystadane doječim materam potrebna previdnost.
Experience with betaine anhydrous therapy in patients with renal insufficiency or non-alcoholic hepatic steatosis has demonstrated no need to adapt the dose regimen of Cystadane.
Izkušnje z zdravljenjem z brezvodnim betainom pri bolnikih z insuficienco ledvic ali nealkoholno steatozo jeter so pokazale, da pri teh bolnikih sheme odmerjanja zdravila Cystadane ni treba prilagajati.
Caution should be exercised with up-titrating doses for patients with CBS deficiency due to the risk for hypermethioninaemia.
Pri titriranju odmerka navzgor pri bolnikih s pomanjkanjem CBS je potrebna previdnost zaradi tveganja za hipermetioninemijo.
If you are taking amino-acid mixture or medicines such as vigabatrin or Gaba analogues (medicine used to treat epilepsy), please tell your doctor as they might interact with your treatment with Cystadane.
Če jemljete mešanico aminokislin ali zdravila, kakršna sta vigabatrin ali zdravila z zdravilnimi učinkovinami, podobnimi GABA (zdravilo za zdravljenje epilepsije), to povejte zdravniku, ker bi ta zdravila lahko vplivala na vaše zdravljenje z zdravilom Cystadane.
Uncommon: brain oedema*
Občasna: možganski edem*
Monitoring plasma homocysteine levels has demonstrated that the onset of action of betaine anhydrous occurred within several days and that a steady-state response was achieved within one month.
S spremljanjem koncentracije homocisteina v plazmi so pokazali, da brezvodni betain začne delovati čez nekaj dni in da se odziv v stanju dinamičnega ravnovesja doseže v enem mesecu.
The use of Cystadane together with other treatments such as vitamin B6, vitamin B12, folate and a specific diet aims to reduce the elevated homocysteine levels in your body.
Cilj uporabe zdravila Cystadane skupaj z drugimi zdravili in vrstami zdravljenja, kot so vitamin B6, vitamin B12, folat in posebna dieta, je znižanje zvišane koncentracije homocisteina v vašem telesu.
• take a heaped spoonful of powder out of the bottle
• Vzemite zvrhano merilno žličko praška iz steklenice.
Based on in vitro data, betaine anhydrous might interact with amino acids mixtures and medicinal products containing vigabatrin and GABA analogues.
Na podlagi podatkov, pridobljenih in vitro, bi se lahko pojavile interakcije brezvodnega betaina z mešanicami aminokislin in zdravil, ki vsebujejo vigabatrin in analoge GABA.
Betaine anhydrous acts as a methyl group donor in the remethylation of homocysteine to methionine in patients with homocystinuria.
Brezvodni betain deluje kot donator metilnih skupin pri ponovnem metiliranju homocisteina v metionin pri bolnikih s homocistinurijo.
Driving and using machines Cystadane has no or negligible influence on the ability to drive and use machines.
Vpliv na sposobnost upravljanja vozil in strojev Zdravilo Cystadane nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
Cystadane treatment should be supervised by a physician experienced in the treatment of patients with homocystinuria.
Zdravljenje z zdravilom Cystadane naj nadzoruje zdravnik, ki ima izkušnje z zdravljenjem bolnikov s homocistinurijo.
Each pack contains 1 bottle with 180 g of powder and three measuring spoons.
Vsaka škatlica vsebuje 1 plastenko s 180 g praška in tri merilne žličke.
Description of selected adverse reactions *Uncommon cases of severe cerebral oedema and hypermethioninemia were reported within 2 weeks to 6 months of starting betaine anhydrous therapy in patients with CBS deficiency, with complete recovery after treatment discontinuation.
Opis izbranih neželenih učinkov * Pri bolnikih s pomanjkanjem CBS so poročali o občasnih primerih težkega možganskega edema in hipermetioninemije 2 tednih do 6 mesecih o začetku zdravljenja z brezvodnim betainom; po prekinitvi zdravljenja so bolniki povsem okrevali.
Cystadane should be used as supplement to other therapies such as vitamin B6 (pyridoxine), vitamin B12 (cobalamin), folate and a specific diet.
Zdravilo Cystadane naj se uporablja kot dodatek drugim zdravilom, na primer vitaminu B6 (piridoksin), vitaminu B12 (kobalamin), folatu in posebni dieti.
Late detection of homocystinuria in symptomatic state is responsible for residual morbidity due to irreversible damage to connective tissue (ophtalmological, skeletal) that cannot be corrected by further therapy.
Pozno odkritje homocistinurije, ko je bolezen že v simptomatskem stadiju, je odgovorno za rezidualno obolevnost zaradi ireverzibilnih okvar vezivnega tkiva (oftalmoloških, skeletnih), ki jih nadaljnje zdravljenje ne more popraviti.
HDPE bottles with a child resistant closure.
Plastenke iz HDPE s pokrovčkom z za otroke varno zaporko.
EXP Shelf life after the first opening: 3 months.
EXP Rok uporabnosti po prvem odpiranju: 3 mesece.
Absorption The absolute bioavailability of betaine anhydrous has not been determined.
Absolutne biološke uporabnosti brezvodnega betaina niso ugotovili.
180 g of oral powder and three measuring spoons.
180 g peroralnega praška in tri merilne žličke.
BOTTLE LABEL
NALEPKA NA STEKLENICI
A. MANUFACTURERs RESPONSIBLE FOR BATCH RELEASE
A. IZDELOVALCI, ODGOVORNI ZA SPROŠČANJE SERIJ
Each carton contains one bottle and three measuring spoons.
Škatla vsebuje eno plastenko in tri merilne žličke.
If you notice side effects like headaches, vomiting or a change in your vision and you are of the homocystinuria subtype called CBS (cystathionine beta-synthase deficiency), please contact your doctor immediately, they could be signs of a swelling in the brain (cerebral oedema).
Če opazite neželene učinke, kot so glavoboli, bruhanje ali spremembe vida, in imate podtip homocistinurije, ki je posledica pomanjkanja encima CBS (cistationin beta-sintaze), se nemudoma obrnite na svojega zdravnika, ker bi to lahko bili znaki možganske otekline (cerebralnega edema).
Lightly shake the bottle before opening.
• Rahlo pretresite steklenico, preden jo odprete.
This will give the following doses: small measure 100 mg, middle size measure 150 mg and large measure 1 g of betaine anhydrous.
Tako boste dobili naslednje odmerke: mala merilna žlička 100 mg, srednja merilna žlička 150 mg in velika merilna žlička 1 g brezvodnega betaina.
How to take Cystadane
Kako jemati zdravilo Cystadane
It is recommended that a heaped measuring spoon is removed from the bottle and a flat surface e.g. base of a knife is drawn across the top of the measure.
Priporočamo, da iz plastenke vzamete zvrhano merilno žličko praška, nato pa čeznjo potegnite z ravno površino, na primer z noževim rezilom.
Long-term carcinogenicity and reproductive toxicity studies have not been conducted on betaine anhydrous.
Dolgoročnih študij kancerogenosti in vpliva na sposobnost razmnoževanja z brezvodnim betainom niso opravili.
Medicinal product subject to restricted medical prescription (see annex I: Summary of Product Characteristics, section 4.2)
Predpisovanje in izdaja zdravila je le na recept s posebnim režimom (glejte Prilogo I: Povzetek glavnih značilnosti zdravila, poglavje 4.2).
Gastrointestinal disorders like diarrhoea, nausea, vomiting, stomach discomfort and inflammation of the tongue may occur uncommonly (may affect up to 1 in 100 people).
Prebavne motnje kot so driska, navzea, bruhanje, nelagodje v trebuhu in vnetje jezika se lahko pojavijo občasno (pri 1 od 100 bolnikov).
In CBS-deficient patients without dietary restriction of methionine, excessive accumulation of methionine has been observed.
Pri bolnikih s pomanjkanjem CBS brez omejitve vnosa metionina s hrano so opazili čezmerno kopičenje metionina.
Betaine anhydrous has also been shown to increase plasma methionine and S-adenosyl methionine (SAM) levels in patients with MTHFR deficiency and cbl defects.
Pokazali so tudi, da brezvodni betain zvišuje koncentracijo metionina in S-adenozilmetionina (SAM) v plazmi pri bolnikih s pomanjkanjem MTHFR in napakami cbl.
What Cystadane contains - The active substance is betaine anhydrous.
Kaj vsebuje zdravilo Cystadane - Zdravilna učinkovina je brezvodni betain.
Biotransformation Betaine anhydrous is a methyl group donor
Brezvodni betain je donor metilne skupine.
Betaine anhydrous was shown to lower plasma homocysteine levels in the three types of homocystinuria, i.e. CBS deficiency; MTHFR deficiency and cbl defect.
Pokazali so, da brezvodni betain znižuje koncentracijo homocisteina v plazmi pri treh vrstah homocistinurije, in sicer pri pomanjkanju CBS, pomanjkanju MTHFR in napaki cbl.
Elevated homocysteine plasma levels are associated with cardiovascular events (such as thrombosis), osteoporosis, skeletal abnormalities, and optic lens dislocation.
Zvišana koncentracija homocisteina v plazmi je povezana s kardiovaskularnimi dogodki, na primer trombozo, z osteoporozo, nenormalnostmi okostja in izpahom očesne leče.
Betaine anhydrous supplementation was shown to improve the metabolic abnormalities in the cerebrospinal fluid of patients with homocystinuria.
Izkazalo se je, da dodajanje brezvodnega betaina izboljša presnovne nenormalnosti v cerebrospinalni tekočini bolnikov s homocistinurijo.
As cerebral oedema has also been reported in patients with hypermethioninemia, secondary hypermethioninemia due to betaine anhydrous therapy has been postulated as a possible mechanism of action.
Ker so pri bolnikih s hipermetioninemijo poročali tudi o možganskem edemu, so domnevali, da je možni mehanizem delovanja sekundarna hipermetioninemija zaradi zdravljenja z brezvodnim betainom.
- If you have any further questions, ask your doctor or your pharmacist.
- Če imate dodatna vprašanja, se posvetujte s svojim zdravnikom ali farmacevtom.
Three measuring spoons (green, blue, pink) dispense 100mg, 150mg or 1g of betaine anhydrous.
Priložene so tri merilne žličke (zelena, modra, rožnata), s katerimi odmerimo 100 mg, 150 mg ali 1 g brezvodnega betaina.
- If any symptoms of cerebral oedema like morning headaches with vomiting and/or visual changes appear, plasma methionine level and compliance to the diet should be checked and treatment with Cystadane interrupted.
- Če se pojavijo simptomi možganskega edema, na primer jutranji glavoboli z bruhanjem ali spremembami vida ali oboje, je treba preveriti koncentracijo metionina v plazmi, ugotoviti, ali se bolnik drži diete, in prekiniti zdravljenje z zdravilom Cystadane.
Unopened bottle: 3 years After the first opening: 3 months.
Neodprta steklenica: 3 leta.
However, the dose should be individually titrated according to plasma levels of homocysteine and methionine.
Vendar je treba odmerek titrirati glede na ravni homocisteina in metionina za vsakega bolnika posebej.
With a slow elimination rate (mean half life = 14 h, mean total body clearance, CL/F, = 84 ml/h/kg),
Z majhno hitrostjo izločanja (povprečni razpolovni čas = 14 ur), povprečni celotni telesni očistek, CL/F = 84 ml/h/kg) je ledvični očistek zanemarljiv (5 % celotnega telesnega očistka), če predpostavimo 100-odstotno biološko uporabnost.
It is presented in bottles with child resistant closures.
Na voljo je v plastenkah s pokrovčkom z za otroke varno zaporko.
Do not take a double dose to make up for forgotten doses.
Če ste pozabili vzeti zdravilo zdravilo Cystadane Ne vzemite dvojnega odmerka, če ste pozabili vzeti prejšnji odmerek.
Each bottle contains 180 g of powder.
Ena plastenka vsebuje 180 g praška.
Cystadane 1 g oral powder
Cystadane 1 g peroralni prašek
Data on a limited number of exposed pregnancies indicate no adverse event of betaine anhydrous on pregnancy or on the health of the foetus/newborn child. To date, no other relevant epidemiologic data are available.
Podatki, zbrani pri omejenem številu nosečnic, ki so bile izpostavljene zdravilu, ne kažejo na možnost škodljivih vplivov brezvodnega betaina na nosečnost ali zdravje zarodka/novorojenca.
After the first opening of the bottle, the medicine should be used within 3 months.
Zdravilo morate porabiti v 3 mesecih od takrat, ko plastenko prvič odprete.
White crystalline free flowing powder.
peroralni prašek Bel kristalen sipek peroralni prašek.
Uncommon cases of severe cerebral oedema associated with hypermethioninemia were reported with betaine anhydrous therapy in patients with CBS deficiency (see section 4.8).
Pri bolnikih s pomanjkanjem CBS so poročali o občasnih primerih težkega možganskega edema, povezanega s hipermetioninemijo, po začetku zdravljenja z brezvodnim betainom (glejte poglavje 4.8).
Three measuring spoons are provided which dispense either 100 mg, 150 mg or 1 g of betaine anhydrous.
Priložene so tri merilne žličke, s katerimi odmerimo 100 mg, 150 mg in 1 g brezvodnega betaina.
• pass the flat back of a knife over the top of the spoon
• Potegnite čez merilno žličko z noževim rezilom.
• the middle size blue spoon measures 150 mg of betaine anhydrous powder ;
• s srednjo žličko odmerite 150 mg betaina v obliki brezvodnega praška;
At high doses, a CNS depressant effect and irritation of the gastrointestinal tract was seen in rats.
Pri podganah so pri velikih odmerkih ugotovili depresiven učinek na centralno živčevje in draženje prebavil.
In general, adverse reactions seen with betaine anhydrous therapy appeared to be not serious and are mainly related to the gastrointestinal system.
Na splošno kaže, da neželeni učinki pri zdravljenju z brezvodnim betainom niso resni, in da se povečini našanajo na prebavila.
Gastrointestinal disorders like diarrhoea, glossitis, nausea, stomach discomfort, vomiting and dental disorders may occur uncommonly.
Občasno se lahko pojavijo prebavne motnje kot so driska, glositis, navzea, nelagodje v trebuhu, bruhanje in bolezni zob.
How to store Cystadane
Shranjevanje zdravila Cystadane
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Datum prve odobritve: 15 februar 2007
Shelf life after the first opening: 3 months.
Rok uporabnosti po prvem odpiranju: 3 mesecev.
Tabulated list of adverse reactions
Seznam neželenih učinkov v obliki tabele
Talk to your doctor or pharmacist before taking Cystadane.
Pred začetkom jemanja zdravila Cystadane se posvetujte z zdravnikom ali farmacevtom.
Symptoms of cerebral oedema include morning headaches with vomiting and/or visual changes High increases in plasma methionine levels in a range from 1,000 to 3,000 µM were noted in these patients.
Pri teh bolnikih so opazili močno zvišanje koncentracije metionina v plazmi, ki je bila med 1.000 in 3.000 µM.
1 g of powder contains 1 g of betaine anhydrous.
1 g praška vsebuje 1 g brezvodnega betaina.
1 g of oral powder contains 1 g of betaine anhydrous.
1 g peroralnega praška vsebuje 1 g brezvodnega betaina.
Detailed information on this medicine is available on the European Medicines Agency web site: http://www.ema.europa.eu/.
Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/, kjer so na voljo tudi povezave do drugih spletnih strani o redkih boleznih in zdravljenju.
• the powder left in the spoon is one spoonful
• V merilni žlički ostane za eno žličko praška.
What Cystadane looks like and contents of the pack Cystadane is a white crystalline free flowing powder.
Zdravilo Cystadane je bel kristalen sipki prašek.
Cystadane 1 g oral powder Betaine anhydrous
Cystadane 1 g peroralni prašek brezvodni betain
• the small green spoon measures 100 mg of betaine anhydrous powder;
• z malo žličko odmerite 100 mg betaina v obliki brezvodnega praška;
Uncommon: diarrhoea, glossitis, nausea, stomach discomfort, vomiting Skin and subcutaneous tissue disorders Uncommon: hair loss, hives, skin odour abnormal Renal and urinary disorders
Občasne: izpadanje las, koprivnica, nenormalen vonj kože
Contact your doctor or pharmacist before stopping.
Preden prenehate, se obrnite na zdravnika ali farmacevta.
Homocystinuria is a disease caused by the accumulation of homocysteine which is not converted to cysteine and is characterised by formation of clots in the veins, bone weakness, and skeletal and crystalline lens abnormalities.
Zanjo je značilno nastajanje strdkov v venah, šibkost kosti in nenormalnosti okostja in očesne leče.