natgillin/translations-raw huggingface dataset:
No additional studies were needed as Pemetrexed Hospira is a generic medicine that is given by infusion and contains the same active substance as the reference medicine, Alimta.
Ker je zdravilo Pemetreksed Hospira generično zdravilo, ki se daje z infundiranjem in vsebuje isto zdravilno učinkovino kot referenčno zdravilo Alimta, niso bile potrebne nobene dodatne študije.
How has Pemetrexed Hospira been studied?
Kako je bilo zdravilo Pemetreksed Hospira raziskano?
How does Pemetrexed Hospira work?
Kako zdravilo Pemetreksed Hospira deluje?
Everyone is different.
Vsi ljudje se med seboj razlikujejo.
Hands should be washed.
Roke morate umiti.
It is recombinant meaning it is not made from human or animal tissue.
Rekombinanten pomeni, da ni narejen iz človeškega ali živalskega tkiva.
Acute critical illness
Akutne kritične bolezni
Long-term safety data are still limited.
Podatkov o dolgoročni varnosti zdravila je še vedno malo.
Patients with PWS and one or more of these risk factors may be at greater risk.
Bolniki s PWS in enim ali več dejavnikov tveganja so bolj ogroženi.
This can start during either adult life or it can continue from childhood.
To se lahko začne v odrasli dobi ali se nadaljuje iz otroštva.
Do not attempt to inject unless you are sure you understand the procedure and requirements for the injection.
Ne poskušajte si ga injicirati, če niste prepričani, da razumete postopek in zahteve glede injiciranja.
• and tell your doctor if you have an active tumour (cancer).
• Povejte svojemu zdravniku, če imate aktivni tumor (raka).
10 A-6336 Langkampfen Austria
10 A-6336 Langkampfen Avstrija
This presentation is intended for multiple use.
Ta oblika je namenjena za večkratno uporabo.
You are now ready to inject the dose.
Zdaj ste pripravljeni za injiciranje odmerka.
Contains benzyl alcohol.
Vsebuje benzilalkohol.
Date of first authorisation: 12 April 2006 Date of latest renewal: 12 April 2011
DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM Datum prve odobritve: 12. april 2006 Datum zadnjega podaljšanja: 12. april 2011
A decrease in peripheral vascular resistance may contribute to this effect.
Zmanjšanje perifernega žilnega upora lahko pripomore k temu učinku.
The powder is white.
Prašek je bel.
• Treatment should be continued until you have stopped growing.
• Zdravljenje naj se nadaljuje, dokler ne nehate rasti.
- Use the solution immediately.
- Raztopino uporabite takoj.
Please read the instructions carefully and follow them step by step.
Prosimo, da skrbno preberete navodila in jih upoštevate.
DATE OF REVISION OF THE TEXT <{MM/YYYY}>
DATUM ZADNJE REVIZIJE BESEDILA <{MM/LLLL}>
Do not inject into this site; withdraw the needle and repeat this step.
Zdravila ne injicirajte na to mesto; iglo izvlecite in ta korak ponovite.
• synthetic adrenal hormones (corticosteroids).
• sintetične adrenalne hormone (kortikosteroide).
• ciclosporin (a medicine that weakens the immune system after transplantation),
• ciklosporin (zdravilo, ki po presaditvi oslabi imunski sistem),
• If you were small or too light at birth.
• če ste bili ob rojstvu premajhni ali prelahki.
In adults
Pri odraslih
Turner syndrome is a genetic disorder in girls that can affect growth - your doctor will have told you if you have this.
Turnerjev sindrom je genetska motnja pri deklicah, ki lahko vpliva na rast - če imate to motnjo, vam je to povedal zdravnik.
As kidneys lose their ability to function normally, this can affect growth.
Ker ledvice izgubljajo svojo sposobnost normalnega delovanja, lahko to vpliva na vašo rast.
Based on this information, these types of patients should not be treated with somatropin.
Na podlagi teh informacij se ti bolniki ne smejo zdraviti s somatropinom.
Women may require higher doses than men.
Pri ženskah so morda potrebni večji odmerki kot pri moških.
In particular, inform your doctor if you are taking or have recently taken any of the following medicines.
Še posebej pa zdravnika obvestite, če jemljete ali ste pred kratkim jemali katero koli od naslednjih zdravil.
• If you are not growing properly and you do not have enough of your own growth hormone.
• če ne rastete pravilno in nimate dovolj lastnega rastnega hormona,
This can be tested by your doctor and if necessary your doctor will prescribe the adequate treatment.
To lahko zdravnik testira in po potrebi predpiše ustrezno zdravljenje.
Treatment should be discontinued after the first year if you are not responding or if you have reached your final height and stopped growing.
Zdravljenje je treba prekiniti po prvem letu, v katerem se ne odzivate na zdravljenje ali če ste dosegli svojo končno višino in nehali rasti.
It is best to use your growth hormone regularly.
Najbolje je, da rastni hormon uporabljate redno.
If you forget to use a dose, have your next injection at the usual time the next day.
Če ste si pozabili dati odmerek, si injicirajte naslednjo injekcijo naslednji dan ob običajnem času.
• If you were too small or too light at birth and are aged between 9 and 12 years, ask your doctor for specific advice relating to puberty and treatment with this medicine.
• Če ste bili ob rojstvu premajhni ali prelahki in ste stari med 9 in 12 leti, vprašajte zdravnika za nasvet, ki se nanaša na puberteto, in zdravljenje s tem zdravilom.
Small for gestational age
Majhnost za gestacijsko starost
When treatment with somatropin is started this deficit is rapidly corrected.
Po začetku zdravljenja s somatropinom se primanjkljaj hitro popravi.
Bedtime is a good time because it is easy to remember.
Primeren čas je pred spanjem, saj si ga je lahko zapomniti.
Reconstitution should be performed in accordance with good practice rules, particularly in the respect of asepsis.
Rekonstrukcijo je treba opraviti skladno s pravili dobre prakse, zlasti glede aseptičnih pogojev:
• medicines to control epilepsy (anticonvulsants),
• zdravilo za nadzor epilepsije (antikonvulzive),
Physical capacity
Telesna zmogljivost
With your other hand, hold the syringe as you would a pencil.
Z drugo roko držite brizgo, kot bi držali svinčnik.
It may cause toxic reactions and allergic reactions in infants and children up to 3 years old.
Lahko povzroči toksične in alergijske reakcije pri dojenčkih in otrocih do 3 leta starosti.
Insert the needle into the pinched skin at an angle of 45° to 90°.
Zabodite iglo v stisnjeno kožo pod kotom 45 do 90 °.
You might feel shaky, sweaty, sleepy or “not yourself”, and you might faint.
Zato se boste morda tresli, se potili, boste zaspani in »ne boste čisto pravi«, lahko pa tudi omedlite.
The minimum effective dose should be used.
Uporabljati je treba najnižji učinkoviti odmerek.
You should not use Omnitrope if you are pregnant or trying to become pregnant.
Zdravila Omnitrope ne smete uporabljati, če ste noseči ali želite zanositi.
Dosage should be monitored every 6 months.
Odmerek je treba vsakih 6 mesecev preveriti.
Scoliosis may progress in any child during rapid growth.
Napreduje lahko pri kateremkoli otroku v obdobju hitre rasti.
The accuracy of the growth hormone dose should therefore be controlled every 6 months.
Ustreznost odmerka rastnega hormona je treba zato preverjati vsakih šest mesecev.
Your excessive fat will decrease and your reduced muscle mass will improve.
Odvečna maščoba se zmanjša in zmanjšana mišična masa se bo izboljšala.
Somatropin may reduce insulin sensitivity.
Somatropin lahko zmanjša občutljivost na insulin.
Your blood sugar level could fall too low and later rise too high.
Raven sladkorja v krvi bi lahko najprej preveč padla in se nato preveč povečala.
This means that there is a risk that women, especially those on oral oestrogen replacement are under-treated while men are over-treated.
To pomeni, da obstaja nevarnost, da bodo ženske, še posebej tiste, ki prejemajo peroralno nadomestno estrogensko zdravljenje, dobile premajhen odmerek, moški pa prevelikega.
• if you are allergic (hypersensitive) to somatropin or to any of the other ingredients of Omnitrope.
• če ste alergični (preobčutljivi) na somatropin ali katero koli sestavino zdravila Omnitrope.
• Experience in patients above 80 years is limited.
• Izkušnje pri bolnikih, starih več kot 80 let, so omejene.
Growth hormone can help you grow taller if you have not been able to catch up or maintain normal growth by 4 years of age or later.
Rastni hormon vam pomaga zrasti, če niste uspeli dohiteti vrstnikov ali vzdrževati normalne rasti pri starosti 4 leta ali več.
Do not shake; this may cause denaturation of the active substance.
Ne stresajte; to lahko povzroči denaturacijo zdravilne učinkovine.
* produced in Escherichia coli by recombinant DNA technology.
* Izdelan iz celic Escherichia coli s tehnologijo rekombinantne DNA.
Your doctor may need to adjust the dose of these medicines or the dose of somatropin.
Morda bo moral vaš zdravnik prilagoditi odmerek teh zdravil ali odmerek somatropina.
• and tell your doctor if Omnitrope has been prescribed to stimulate growth but you have already stopped growing (closed epiphyses).
• Povejte zdravniku, če vam je bilo zdravilo Omnitrope predpisano za spodbujanje rasti, a ste že prenehali rasti (zaprte epifize).
However, no link has been made between these cases and treatment with Omnitrope.
Vendar pa povezave med temi primeri in zdravljenjem z zdravilom Omnitrope niso ugotovili.
It should be reconstituted with a transfer set as recommended in the information provided with the transfer set.
Raztopino je treba pripraviti s setom za prenos, kot je to priporočeno v informacijah, priloženih setu za prenos.
Muscle strength and physical exercise capacity are improved after long-term treatment with somatropin.
Mišična moč in telesna zmogljivost se izboljšata po dolgotrajnem zdravljenju s somatropinom.
The maximum recommended daily dose should not be exceeded (see section 4.2).
Največjega priporočenega dnevnega odmerka se ne sme prekoračiti (glejte poglavje 4.2).
If on repeated measurements IGF-I levels exceed +2 SD compared to references for age and pubertal status, the IGF-I / IGFBP-3 ratio could be taken into account to consider dose adjustment.
Če pri ponovljenih meritvah ravni IGF-I presegajo +2 SD v primerjavi z referenčnimi vrednostmi za starost in puberteto, se za preučitev prilagoditve odmerkov lahko upošteva razmerje IGF-I/IGFBP-3.
Wait for the area to dry.
Počakajte, da se predel posuši.
If necessary, glucocorticoid replacement should be initiated.
Po potrebi je treba začeti z nadomeščanjem glukokortikoidov.
Do not change the dosage and treatment schedule without consulting your doctor.
Odmerka in režima zdravljenja ne spreminjajte, ne da bi se prej posvetovali z zdravnikom.
Neoplasms Benign, Malignant and Unspecified (including cysts and polyps)
Benigne, maligne in neopredeljene novotvorbe (vključno s cistami in polipi)
But it is unknown if these 2 pathologies are more frequent or not while treated with somatropin.
Vendar ni znano, ali sta ti dve bolezenski stanji pogostejši pri zdravljenju s somatropinom ali ne.
• If you have Turner syndrome.
• če imate Turnerjev sindrom.
8°C in the original package.
2 °C-8 °C v originalni ovojnini.
The clinical relevance of these findings may be limited.
Klinična pomembnost teh izsledkov je lahko omejena.
Growth hormone will help you grow taller if you are still growing, and will also improve your body composition.
Rastni hormon vam pomaga če še vedno rastete, izboljša pa tudi sestavo telesa.
If you are about to have, or have had, a major operation, or go into hospital for any reason, tell your doctor and remind the other doctors you are seeing that you use growth hormone.
Če načrtujete ali ste imeli veliko operacijo ali če greste zaradi kateregakoli razloga v bolnišnico, povejte svojemu zdravniku in opomnite vse druge zdravnike, da uporabljate rastni hormon.
Also see section 4.4 for statements regarding diabetes mellitus and thyroid disorder and section 4.2 for statement on oral oestrogen replacement therapy.
Glejte tudi poglavje 4.4 o ugotovitvah, ki se nanašajo na diabetes mellitus in motnje delovanja ščitnice, ter poglavje 4.2 o ugotovitvah, ki se nanašajo na peroralno estrogensko nadomestno zdravljenje.
Somatropin must not be used for growth promotion in children with closed epiphyses.
Somatropina se ne sme uporabljati za pospeševanje rasti otrok z zaprtimi epifizami.
It will also stop air going back into the pen and the needle clogging up.
To bo tudi preprečilo vstop zraka nazaj v peresnik in zamašitev igle.
Omnitrope has no or negligible influence on the ability to drive and use machines.
Zdravilo Omnitrope nima vpliva ali ima zanemarljiv vpliv na sposobnost vožnje in upravljanja s stroji.
The recommended dose is for:
Priporočeni odmerek je:
A dose correction can be needed after six months of treatment (see section 4.4).
Prilagodi se ga lahko po šestih mesecih zdravljenja (glejte poglavje 4.4).
Somatropin also increases cardiac output, but the mechanism has yet to be clarified.
Somatropin prav tako zveča minutni srčni volumen, vendar njegov mehanizem še ni pojasnjen.
To verify growth disturbance, growth should be followed for a year preceding institution of therapy.
Da bi potrdili motnje rasti, je treba rast spremljati eno leto pred začetkom zdravljenja.
Experience with prolonged treatment in adults and in patients with PWS is limited.
Izkušenj s podaljšanim zdravljenjem odraslih in bolnikov s PWS je malo.
Women may require higher doses than men, with men showing an increasing IGF-I sensitivity over time.
Ženske utegnejo potrebovati večje odmerke od moških, kajti pri moških se občutljivost na IGF-I sčasoma zveča.
In children
Pri otrocih
However, there is no evidence of an increased risk of leukaemia without predisposition factors, such as radiation to the brain or head.
Vendar ni dokazov za povečano tveganje za levkemijo brez predispozicijskih dejavnikov, kot je obsevanje možganov ali glave.
The following is a general description of the reconstitution and administration process.
V nadaljevanju sledi splošni opis postopka rekonstitucije in uporabe.
Experience in patients with Silver-Russell syndrome is limited.
Izkušenj pri bolnikih s SilverRussellovim sindromom je malo.
In addition, the following actions have been demonstrated.
Ugotovili pa so še naslednje delovanje:
In children Omnitrope is used to treat the following growth disturbances:
Zdravilo Omnitrope se pri otrocih uporablja za zdravljenje naslednjih motenj v rasti:
In children such adverse reactions are uncommon.
Take neželene reakcije so pri otrocih občasne.
You should only be given this medicine by a doctor who has experience with growth hormone treatment and who has confirmed your diagnosis.
Zdravilo vam sme dati samo zdravnik z izkušnjami v zdravljenju z rastnim hormonom, ki je vašo diagnozo potrdil.
It has the same structure as natural human growth hormone which is needed for bones and muscles to grow.
Po zgradbi je enak naravnemu človeškemu rastnemu hormonu, ki je potreben za rast kosti in mišic.
It is recognized that there are patients with GHD who do not normalize IGF-I levels despite a good clinical response, and thus do not require dose escalation.
Upoštevati je treba, da obstajajo bolniki s PRH, pri katerih se ravni IGF-I ne normalizirajo, kljub dobremu kliničnemu odzivu, zato odmerka ni treba povečati.
Your doctor will advise you about your individualised dose of Omnitrope in milligrams (mg) from either your body weight in kilograms (kg) or your body surface area calculated from your height and weight in square metres (m2), as well as your treatment schedule.
Vaš zdravnik vam bo svetoval, kakšen je vaš individualni odmerek zdravila Omnitrope v miligramih (mg) na podlagi vaše telesne mase v kilogramih (kg) ali vaše telesne površine, ki jo bo izračunal iz vaše višine in telesne mase v kvadratnih metrih (m2), ter vam izdelal režim zdravljenja.
• Type 2 diabetes • A decrease in the levels of the hormone Cortisol in your blood
• sladkorna bolezen tipa 2 • znižanje ravni hormona kortizola v krvi
Tables 1-6 show the adverse reactions ranked under headings of System Organ Class and frequency using the following convention: very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); not known (cannot be estimated from the available data) for each of the indicated conditions.
V preglednicah 1-6 so prikazani neželeni učinki, razvrščeni po organskih sistemih, z navedbo pogostnosti po naslednjem dogovoru: zelo pogosti (≥ 1/10); pogosti (≥ 1/100 do < 1/10); občasni (≥ 1/1.000 do < 1/100); redki (≥ 1/10.000 do < 1/1.000); zelo redki (< 1/10.000); neznana (ni mogoče oceniti iz razpoložljivih podatkov) za vsako indicirano stanje.
Treatment should be discontinued if height velocity is < 2 cm/year and, if confirmation is required, bone age is > 14 years (girls) or > 16 years (boys), corresponding to closure of the epiphyseal growth plates.
Zdravljenje je treba prekiniti, če je hitrost rasti < 2 cm/leto oz. če je kostna starost > 14 let (deklice) ali > 16 let (dečki), kar je v skladu z zapiranjem epifiznih rastnih ploščic.
It is therefore not recommended to initiate treatment near onset of puberty.
Zato se ne priporoča začetek zdravljenja tik pred začetkom pubertete.
Symptoms: Acute overdose could lead initially to hypoglycaemia and subsequently to hyperglycaemia.
Simptomi: Akutno preveliko odmerjanje lahko najprej povzroči hipoglikemijo, pozneje pa hiperglikemijo.
Inject your growth hormone at about the same time every day.
Rastni hormon si vsak dan injicirajte ob istem času.
Leukaemia†
levkemija†
Literature data from untreated SGA children/adolescents without early spontaneous catch-up suggest a late growth of 0.5 SDS.
Podatki iz literature o nezdravljenih otrocih/mladostnikih, ki se rodijo MGS, brez zgodnjega spontanega približevanja, kažejo pozno rast 0,5 SSD.
A small percentage of patients may develop antibodies to Omnitrope.
Pri majhnem odstotku bolnikov se lahko razvijejo protitelesa za zdravilo Omnitrope.
The binding capacity of these antibodies has been low and no clinical changes have been associated with their formation, see section 4.4.
Sposobnost vezave teh protiteles je majhna in kliničnih sprememb, povezanih z njihovim nastajanjem, ni, glejte poglavje 4.4.
All other patients will require IGF-I assay and one growth hormone stimulation test.
Pri vseh drugih bolnikih je treba opraviti test IGF-I in en stimulacijski test rastnega hormona.
If you are pregnant or breast feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Če ste noseči ali dojite, menite, da bi lahko bili noseči ali načrtujete zanositev, se posvetujte z zdravnikom ali farmacevtom, preden vzamete to zdravilo.
Other possible side effects related to your treatment with growth hormone may include the following: You (or your child) may experience a high blood sugar or reduced levels of thyroid hormone.
Drugi možni neželeni učinki, povezani z zdravljenjem z rastnim hormonom, lahko vključujejo naslednje: pri vas (ali vašem otroku) se lahko pojavijo visoke ravni sladkorja v krvi ali znižane ravni ščitničnega hormona.
Information about the pharmacokinetics of somatropin in geriatric and paediatric populations, in different races and in patients with renal, hepatic or cardiac insufficiency is either lacking or incomplete.
Podatkov o farmakokinetičnih lastnostih somatropina pri starejših ljudeh in otrocih, pri različnih rasah ter pri bolnikih z ledvično, jetrno ali srčno insuficienco bodisi ni bodisi so nepopolni.
Remove the pen needle and dispose of it in accordance with local requirements.
Iglo peresnika odstranite in zavrzite v skladu z lokalnimi predpisi.
- Childhood onset: Patients who were growth hormone deficient during childhood as a result of congenital, genetic, acquired, or idiopathic causes.
- Začetek v otroštvu: pri bolnikih, ki so imeli pomanjkanje rastnega hormona v otroštvu zaradi prirojenega, genetskega, pridobljenega ali idiopatskega vzroka.
Clinical trials in PWS
Klinična preskušanja pri PWS
- Pull back on the plunger slowly and withdraw just a bit more than the dose prescribed by your doctor into the syringe.
- Počasi potiskajte bat nazaj in načrpajte v brizgo le nekoliko večjo količino, kot je odmerek, ki vam ga je predpisal zdravnik.
The best sites for injection are tissues with a layer of fat between skin and muscle, such as the thigh or belly (except the navel or waistline).
Najprimernejša mesta za injiciranje so tkiva s plastjo maščobe med kožo in mišicami, npr. stegno ali trebuh (razen popka ali pasu).
If severe growth hormone deficiency is confirmed, your doctor will propose continuation of Omnitrope treatment.
Če se potrdi hudo pomanjkanje rastnega hormona, bo vaš zdravnik predlagal nadaljevanje zdravljenja z zdravilom Omnitrope.
For instructions for use and handling see section 6.6.
Za navodila za pripravo in ravnanje z zdravilom glejte poglavje 6.6.
For monitoring, the attainment of a normal peak bone mass defined as a T score > -1 (i.e. standardized to average adult peak bone mass measured by dual energy X-ray absorptiometry taking into account sex and ethnicity) is one of the therapeutic objectives during the transition period.
Za nadziranje je doseg normalne najvišje kostne mase, opredeljene kot seštevek T > -1 (tj. standardizirano na povprečno odraslo najvišjo kostno maso, izmerjeno z dvoenergetsko rentgensko absorpciometrijo z upoštevanjem spola in etnične pripadnosti), eden od ciljev zdravljenja v prehodnem obdobju.
Omnitrope is a recombinant human growth hormone (also called somatropin).
Zdravilo Omnitrope je rekombinantni humani rastni hormon (imenovan tudi somatropin).
In adults as well as in children, somatropin maintains a normal body composition by increasing nitrogen retention and stimulation of skeletal muscle growth, and by mobilisation of body fat.
Pri odraslih in tudi pri otrocih vzdržuje normalno zgradbo organizma tako, da povečuje retenco dušika in spodbuja rast skeletnih mišic, ter z mobilizacijo telesne maščobe.
• If you have Prader-Willi syndrome (a chromosomal disorder).
• če imate Prader-Willijev sindrom (kromosomska motnja).
Treatment should be discontinued after the first year of treatment if the height velocity SDS is below + 1.
Po prvem letu zdravljenja je treba zdravilo prenehati uporabljati, če je SSD hitrosti rasti manj kot +1.
Your doctor may need to adjust the dose of Omnitrope or of the other medicines:
Zdravnik bo morda moral prilagoditi odmerek zdravila Omnitrope ali drugih zdravil:
• Your doctor will check your blood sugar and insulin levels before the start of treatment and every year during treatment.
• Vaš zdravnik bo preverjal ravni sladkorja v krvi in insulina, preden se začnete zdraviti in nato vsako leto med zdravljenjem.
Reduced serum cortisol levels
Zmanjšanje ravni kortizola v serumu
If you inject much more than you should, contact your doctor or pharmacist as soon as possible.
Če ste si injicirali večji odmerek, kot bi smeli, se čim prej posvetujte s svojim zdravnikom ali farmacevtom.
Dose recommendations in paediatric patients
Priporočeno odmerjanje pri pediatričnih bolnikih
• Pain or burning sensation in the hands or underarms (known as Carpal Tunnel syndrome)
• bolečina ali pekoč občutek v rokah ali podlahteh (znana kot sindrom karpalnega kanala)
If you use more Omnitrope than you should
Če ste uporabili večji odmerek zdravila Omnitrope, kot bi smeli
Diagnosis and therapy with somatropin should be initiated and monitored by physicians who are appropriately qualified and experienced in the diagnosis and management of patients with growth disorders.
Diagnozo in zdravljenje s somatropinom mora začeti in nadzirati zdravnik, ki je ustrezno usposobljen in ima izkušnje pri diagnosticiranju in obravnavanju bolnikov z motnjami rasti.
Patients with normal IGF-I concentrations at the start of the treatment should be administered growth hormone up to an IGF-I level into the upper range of normal, not exceeding the 2 SDS.
Bolniki z normalnimi koncentracijami IGF-I na začetku zdravljenja prejemajo rastni hormon do zgornje meje normalne vrednosti IGF-I, ki ne presega 2 SDS.
Growth hormone increases the extrathyroidal conversion of T4 to T3 which may result in a reduction in serum T4 and an increase in serum T3 concentrations.
Rastni hormone poviša ekstratiroidno pretvorbo T4 v T3, kar lahko povzroči zmanjšanje serumske vrednosti T4 in zvečanje koncentracije T3.