natgillin/translations-raw huggingface dataset:
Retinoids applied to the skin are used to treat various skin conditions including mild to moderate acne.
Na kožo naneseni retinoidi se uporabljajo za zdravljenje različnih bolezni kože, vključno z zmernimi do zmerno hudimi aknami.
• Retinoid medicines, used mainly to treat conditions affecting the skin such as severe acne, are harmful to the unborn baby if taken during pregnancy.
• Retinoidna zdravila, ki se uporabljajo predvsem za zdravljenje bolezni, ki prizadenejo kožo, npr. hudih aken, so ob jemanju med nosečnostjo škodljiva za nerojenega otroka.
Available data suggest that topical retinoids do not carry a risk of neuropsychiatric side effects, and therefore no additional warnings need to be added to the prescribing information.
Razpoložljivi podatki kažejo da topični retinoidi niso povezani s tveganji za nevropsihiatrične neželene učinke, zato ni treba informacij o predpisovanju dopolniti z nobenim dodatnim opozorilom.
• For bexarotene and oral tretinoin it is considered that, in the light of the target population and an oncological indication subject to specialist care in the hospital setting, the implementation of a PPP is not necessary.
• Pri beksarotenu in peroralnem tretinoinu velja, da zaradi ciljne populacije in onkološke indikacije, ki se obravnava v specialističnem bolnišničnem okolju izvedba programa za preprečevanje nosečnosti ni nujna.
• In addition, the oral retinoids acitretin, alitretinoin and isotretinoin must not be taken by women able to have children unless the conditions of a special pregnancy prevention programme are met.
• Poleg tega peroralnih retinoidov acitretina, alitretinoina in izotretinoina ne smejo jemati ženske, ki imajo lahko otroke, razen če so izpolnjeni pogoji posebnega programa za preprečevanje nosečnosti.
− pregnancy tests before, during and after stopping treatment;
− nosečnostne teste pred zdravljenjem, med njim in po ustavitvi zdravljenja;
However, as a precaution, topical retinoids are contraindicated in pregnant women and in women planning a pregnancy.
Vseeno pa so kot previdnostni ukrep pri nosečnicah in ženskah, ki načrtujejo nosečnost, kontraindicirani.
− pregnancy tests before starting treatment, during treatment and after treatment;
− nosečnostni testi pred začetkom zdravljenja, med njim in po zdravljenju;
In addition, the oral retinoids acitretin, alitretinoin and isotretinoin, which are used to treat conditions mainly affecting the skin, must be used in accordance with the conditions of a new pregnancy prevention programme by women able to have children.
Poleg tega je treba peroralne retinoide acitretin, alitretinoin in izotretinoin, ki se uporabljajo za zdravljenje bolezni, ki prizadenejo predvsem kožo, uporabljati skladno s pogoji novega programa za preprečevanje nosečnosti pri ženskah, ki imajo lahko otroke.
Information for healthcare professionals A review of available data on teratogenicity and neuropsychiatric disorders with retinoid medicines has concluded that there is the need to strengthen the recommendations for pregnancy prevention and to raise awareness about possible neuropsychiatric risks.
Pregled razpoložljivih podatkov o teratogenosti in nevropsihiatričnih motnjah, povezanih z uporabo retinoidov, je pokazal, da je treba okrepiti priporočila za preprečevanje nosečnosti in povečati seznanjenost z možnimi nevropsihiatričnimi tveganji.
Retinoids include the active substances acitretin, adapalene, alitretinoin, bexarotene, isotretinoin, tazarotene and tretinoin.
Retinoidi vključujejo učinkovine acitretin, adapalen, alitretinoin, beksaroten, izotretinoin, tazaroten in tretinoin.
Topical retinoids (those applied to the skin) must also not be used during pregnancy, and by women planning to have a baby.
Prav tako se v nosečnosti ne smejo uporabljati topični retinoidi (tisti, ki se nanašajo na kožo), uporabljati pa jih ne smejo niti ženske, ki načrtujejo otroka.
• The pregnancy prevention programme for acitretin, alitretinoin and isotretinoin includes:
• Program za preprečevanje nosečnosti ob uporabi acitretina, alitretinoina in izotretinoina bo vključeval:
• Oral retinoids (acitretin, alitretinoin, bexarotene, isotretinoin and tretinoin) are highly teratogenic and must not be used during pregnancy.
• Peroralni retinoidi (acitretin, alitretinoin, beksaroten, izotretinoin in tretinoin) so zelo teratogeni in se med nosečnostjo ne smejo uporabljati.
Warning on possible risk of neuropsychiatric disorders also to be included for oral retinoids
Za peroralne retinoide bo vključeno tudi opozorilo o možnem tveganju za nevropsihiatrične motnje
− a ‘risk acknowledgement form' for patients and prescribers to go through and confirm that appropriate advice has been given and understood.
− „potrditveni obrazec“ za bolnice in osebe, ki zdravila predpisujejo, da ga preberejo in potrdijo, da so prejeli/dali potrebne nasvete glede tveganj in da so jih bolnice razumele.
• For topically applied retinoids (adapalene, alitretinoin, isotretinoin, tazarotene and tretinoin), systemic absorption is negligible, and unlikely to result in psychiatric disorders.
• Retinoidi, ki se uporabljajo topično (adapalen, alitretinoin, izotretinoin, tazaroten in tretinoin), se sistemsko absorbirajo zanemarljivo malo in je le malo verjetno, da bi povzročili psihiatrične motnje.
• Cases of depression, depression-aggravated anxiety and mood alterations have been reported rarely in patients taking oral retinoids.
• Pri bolnicah, ki jemljejo peroralne retinoide, so v redkih primerih poročali o depresiji, z depresijo poslabšani tesnobi in spremembah razpoloženja.
In addition, a warning on the possibility that neuropsychiatric disorders (such as depression, anxiety and mood changes) may occur will be included in the prescribing information for oral retinoids (those taken by mouth).
Poleg tega bo v informacije o predpisovanju za peroralne retinoide (tj. tiste retinoide, ki se jemljejo peroralno) vključeno tudi opozorilo o možnosti pojava nevropsihiatričnih motenj (npr. depresije, tesnobe in sprememb razpoloženja).
• Updated educational material will be provided to guide the discussion about the risks of oral retinoids before prescribing acitretin, alitretinoin and isotretinoin to women of childbearing potential.
• Ženske v rodni dobi bodo prejele posodobljeno izobraževalno gradivo, preden jim bodo predpisani acitretin, alitretinoin ali izotretinoin.
• Acitretin, alitretinoin and isotretinoin must be used in accordance with the conditions of a pregnancy prevention programme (PPP) for all women of childbearing potential.
• Acitretin, alitretinoin in izotretinoin je treba pri vseh plodnih ženskah uporabljati skladno s pogoji programa za preprečevanje nosečnosti.
On this basis, it has not been possible to identify a clear increase in the risk of neuropsychiatric disorders in people who take oral retinoids compared to those that do not.
Na podlagi tega pri ljudeh, ki jemljejo peroralne retinoide, ni bilo mogoče prepoznati jasnega povečanja tveganja za nevropsihiatrične motnje.
• For topical retinoids (adapalene, alitretinoin, isotretinoin, tazarotene and tretinoin), the available data show that systemic absorption is negligible following topical application and that these products are unlikely to cause fetal harm.
• Razpoložljivi podatki kažejo, da je sistemska absorpcija topičnih retinoidov (adapalena, alitretinoina, izotretinoina, tazarotena in tretinoina) po nanosu na kožo zanemarljiva in da ta zdravila najverjetneje ne škodujejo plodu.
• Topical (applied to the skin) retinoids are less likely to cause harm to the unborn child.
• Topični (nanašanje na kožo) retinoidi manj verjetno škodujejo nerojenemu otroku, vendar se zaradi previdnosti med nosečnostjo ne smejo uporabljati, prav tako pa jih ne smejo uporabljati ženske, ki načrtujejo otroka.
List of the names, pharmaceutical form, strengths of the medicinal product, route of administration, applicants in the Member States
Seznam imen, farmacevtskih oblik, jakosti zdravila, poti uporabe zdravila in predlagateljev v državah članicah
Strength Pharmaceutical form Route of administration
Farmacevtska oblika Pot uporabe zdravila
- if you are older than 70 years of age.
- Če ste starejši od 70 let.
However, no unacceptable risks appear to be present in this patient group.
Vendar pa ne kaže, da bi v tej skupini bolnikov prihajalo do nesprejemljivih tveganj.
Supportive measures should be provided as necessary.
Treba je poskrbeti za ustrezne podporne ukrepe.
Errors in how you take this medicine may have serious health consequences.
Napačno jemanje tega zdravila ima namreč lahko resne posledice za zdravje.
• raised liver enzymes (your doctor will check this)
• povečana količina jetrnih encimov (to bo preveril vaš zdravnik)
For the eligible histology population, the efficacy results were similar.
Pri ustrezni histološki populaciji so bili rezultati učinkovitosti podobni.
feeling that one's surroundings are spinning
občutek, da se okolica vrti
In this case, your doctor will also prescribe medicine to help you prevent this typeof pneumonia (PCP).
V tem primeru vam bo zdravnik predpisal tudi zdravilo za preprečevanje tega tipa pljučnice (PCP).
During treatment patients should be monitored and managed appropriately.
Med zdravljenjem je potrebno ustrezno spremljati in obravnavati bolnike.
Avoid inhaling the powder.
Izognite se vdihavanju praška.
TMZ can have genotoxic effects.
TMZ ima lahko genotoksične učinke.
• dose level -1 (100 mg/m2 ) still results in unacceptable toxicity
• stopnja odmerka -1 (100 mg/m2 ) še vedno povzroči nesprejemljivo toksičnost
Once the radiotherapy is completed, you will interrupt treatment for 4 weeks to give your body a chance to recover.
Ko bo radioterapija zaključena, boste zdravljenje prekinili za 4 tedne, da si vaše telo opomore.
These blood cells are important for fighting infection and for proper blood clotting.
Te krvne celice so pomembne za boj proti okužbam in za pravilno strjevanje krvi.
Capsules should not be opened.
Kapsul se ne sme odpirati.
There are no data in pregnant women.
Ni podatkov o uporabi pri nosečih ženskah.
Hypersensitivity to dacarbazine (DTIC).
Preobčutljivost za dakarbazin (DTIC).
Do not double the next dose to make up for a forgotten dose, unless your doctor tells you to do so.
Ne vzemite dvojnega odmerka, da bi nadoknadili pozabljeni odmrek, razen če vam to naroči zdravnik.
- if you have had an allergic reaction to another anti-cancer medicine called dacarbazine.
- če ste imeli alergijsko reakcijo na drugo zdravilo za zdravljenje raka, imenovano dakarbazin.
This latency period is very short even for an alkylating agent.
Ta latentna doba je zelo kratka celo za alkilirajočo snov.
Temozolomide treatment can cause a reduction in certain kinds of blood cells.
Zdravljenje s temozolomidom lahko povzroči zmanjšanje števila nekaterih vrst krvnih celic.
The median PFS was 5.4 months.
Mediana vrednost PFS je bila 5,4 mesecev.
Reduction for prior toxicity
Zmanjšanje zaradi predhodne toksičnosti
Medical attention may be required.
Morda boste potrebovali zdravniško pomoč.
Your blood will be tested regularly to monitor your condition.
Vašo kri bodo redno pregledovali in tako spremljali vaše stanje.
Do not give this medicine to children under the age of 3 years because it has not been studied.
Tega zdravila ne dajajte otrokom mlajšim od 3 let, ker pri njih zdravila niso preučevali.
In this case, do not drive or use any tools or machines or cycle until you see how this medicine affects you (see section 4).
V tem primeru ne smete voziti ali uporabljajti orodij in ne upravljajti strojev, ali se voziti s kolesom, dokler ne ugotovite, kako zdravilo vpliva na vas (glejte poglavje 4).
The capsules must be swallowed whole with a glass of water and must not be opened or chewed.
Kapsule je treba pogoltniti cele s kozarcem vode in se jih ne sme odpirati ali žvečiti.
The major route of 14C elimination is renal.
Glavna pot izločanja 14C je skozi ledvice.
Opportunistic infections, including PCP
oportunistične infekcije, vključno s PCP
Do not use this medicine after the expiry date which is stated on the label and carton.
Zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki in škatli.
The reduction of blood cells is usually temporary, but in some cases may be for longer and may lead to a very severe form of anaemia (aplastic anaemia).
Zmanjšanje števila krvnih celic je ponavadi začasno, vendar pa lahko v nekaterih primerih traja dlje in pripelje do hude oblike anemije (aplastična anemija).
Dose during Cycle 1
Odmerek med 1. ciklom
As it cannot be excluded that the change in Cmax is clinically significant, Temozolomide Accord should be administered without food.
Ker ni mogoče izključiti možnosti, da je sprememba Cmax klinično pomembna, je treba zdravilo Temozolomid Accord jemati brez hrane.
• palpitations (abnormal heart beats)
• palpitacije (nenormalni srčni utripi)
Dose during Cycles 2-6 in absence of toxicity Table 3.
Odmerek med cikli 2-6 v odsotnosti toksičnosti Preglednica 3.
• discolouration of your tongue
• razbarvanost jezika
Administration of TMZ with food resulted in a 33 % decrease in Cmax and a 9 % decrease in area under the curve (AUC).
Jemanje TMZ s hrano je povzročilo 33 % zmanjšanje Cmax in 9 % zmanjšanje površine pod krivuljo (AUC).
TMZ demonstrates low protein binding (10% to 20%), and thus it is not expected to interact with highly protein-bound substances.
TMZ izkazuje majhno stopnjo vezave na beljakovine (10 % do 20 %), zato medsebojnega delovanja z učinkovinami, ki se v veliki meri vežejo na beljakovine, ni pričakovati.
Your doctor will decide whether any change in your treatment is needed.
Vaš zdravnik bo določil, ali je potrebna kakšna sprememba vašega zdravljenja.
Swallow the capsule(s) whole with a glass of water.
Kapsulo (kapsule) pogoltnite celo (cele) s kozarcem vode.
Symptoms of diabetes insipidus include passing a lot of urine and feeling thirsty.
Simptomi diabetesa insipidusa vključujejo izločanje večje količine urina in občutek žeje.
• changes in blood cells,
• spremembe krvnih celic,
Then there may be up to 6 treatment cycles, and each one lasts 28 days.
Nato lahko sledi še do 6 ciklov zdravljenja, vsak pa traja 28 dni.
The lowest recommended dose is 100 mg/m2.
Najmanjši priporočen odmerek je 100 mg/m2.
Dose levels include 100 mg/m2, 150 mg/m2, and 200 mg/m2.
Stopnje odmerkov vključujejo 100 mg/m2, 150 mg/m2, in 200 mg/m2.
Myelosuppression was predictable (usually within the first few cycles, with the nadir between Day 21 and Day 28), and recovery was rapid, usually within 1-2 weeks.
Mielosupresija je bila predvidljiva (navadno v prvih nekaj ciklih in je bila najizrazitejša med 21. in 28. dnevom), okrevanje pa je bilo hitro, običajno v enem do dveh tednih.
If the dose was not escalated at Cycle 2, escalation should not be done in subsequent cycles.
Če se odmerek ne poveča v 2. ciklu, se ga ne sme povečati niti v naslednjih ciklih.
You will take this dose every day for 42 days (up to 49 days) in combination with radiotherapy.
Ta odmerek boste jemali 42 dni (do 49 dni) vsak dan v kombinaciji z radioterapijo.
In some cases, it may be necessary to stop treatment with temozolomide.
Možno je, da bo v nekaterih primerih treba prekiniti zdravljenje s temozolomidom.
If lymphopenia occurs, they are to continue the prophylaxis until recovery of lymphopenia to grade ≤1.
Če nastopi limfopenija, morajo nadaljevati s profilakso, dokler se limfopenija ne povrne na stopnjo ≤ 1.
Figure 1 Kaplan-Meier curves for overall survival (intent-to-treat population)
Slika 1 Kaplan-Meierjeve krivulje skupnega preživetja (populacija, ki naj bi jo zdravili)
Paediatric patients had a higher AUC than adult patients; however, the maximum tolerated dose (MTD) was 1,000 mg/m2 per cycle both in children and in adults.
Pediatrični bolniki so imeli večji AUC kot odrasli bolniki, vendar je bil največji odmerek, ki so ga bolniki še prenašali (MTD - »maximum tolerated dose«) 1.000 mg/m2 na cikel pri otrocih in odraslih.
TMZ is more toxic to the rat and dog than to humans, and the clinical dose approximates the minimum lethal dose in rats and dogs.
TMZ je bolj toksičen za podgane in pse kot ljudi, klinični odmerek pa je približno enak minimalnemu letalnemu odmerku za podgane in pse.
• change in your sense of smell
• spremembe občutka za vonj
Your doctor will decide the correct dose of temozolomide for you to take, based on your size (height and weight) and whether you have had chemotherapy treatment.
Vaš zdravnik bo določil ustrezen odmerek temozolomida, ki ga boste jemali glede na vašo velikost (višino in telesno maso) in na osnovi tega, ali ste že imeli kemoterapijo.
Opportunistic infections and reactivation of infections
Oportunistične okužbe in reaktivacija okužb
The carton contains one bottle.
Škatla vsebuje eno stekleničko.
Each time you start a new treatment cycle, be sure you understand exactly how many capsules of each strength you need to take each day and how many days you will receive this dose.
Vsakič, ko začnete nov cikel zdravljenja, se prepričajte, da res veste, koliko kapsul kakšne jakosti morate vzeti vsak dan in koliko časa morate jemati ta odmerek.
If Temozolomide Accord comes into contact with skin or mucosa, it should be washed immediately and thoroughly with soap and water.
Če pride zdravilo Temozolomid Accord v stik s kožo ali sluznico, je treba takoj in temeljito izprati z milom in vodo.
However, because the doses implicated in retinal degeneration were in the lethal dose range, and no comparable effect has been observed in clinical studies, this finding was not considered to have clinical relevance.
Ker pa so bili odmerki, pri katerih je prišlo do degeneracije mrežnice v območju letalnih odmerkov in ker v kliničnih študijah ni bilo primerljivih učinkov, se ta podatek ne smatra kot klinično pomemben.
• pain with urination
• bolečine pri uriniranju
- you may have a small risk of other changes in blood cells, including leukaemia.
- Obstaja tudi majhno tveganje za druge spremembe krvnih celic, vključno z levkemijo.
Ask your doctor or pharmacist to write down the number of each strength (including colour) that you need to take each dosing day.
Prosite svojega zdravnika ali farmacevta, da vam napiše število kapsul vsake jakosti (in pripiše tudi njihovo barvo), ki jih morate vzeti vsak dan jemanja zdravila.
SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND REACH OF CHILDREN
SPECIAL WARNING THAT THE MEDICINAL PRODUCT MUST BE STORED OUT OF THE SIGHT AND OF CHILDREN
CTC Grade 4b a : TMZ dose levels are listed in Table 2. b : TMZ is to be discontinued if:
SMT stopnje 4b a : Stopnje odmerka TMZ so navedene v preglednici 2. b : Jemanje TMZ je treba prenehati, če:
Post-marketing experience
Postmarketinške izkušnje:
If you vomit frequently before or during treatment, ask your doctor about medicines to help prevent vomiting or control the vomiting and the best time to take temozolomide until the vomiting is under control.
Če pogosto bruhate pred ali po zdravljenju, svojega zdravnika povprašajte o zdravilih, ki pomagajo preprečiti ali omejiti bruhanje, in o najboljšem času za jemanje temozolomida, dokler bruhanje ni pod nadzorom.
During treatment a complete blood count should be obtained weekly.
Med zdravljenjem je treba vsak teden preveriti celotno krvno sliko.
There may be a higher occurrence of PCP when TMZ is administered during a longer dosing regimen.
Možno je, da je pojavnost PCP večja takrat, ko se TMZ uporablja v daljšem režimu odmerjanja.
In the tables, undesirable effects are classified according to System Organ Class and frequency.
V preglednicah so neželeni učinki razvrščeni po organskih sistemih in pogostnosti.
See footnote b
Glejte opombo b
The presence of thrombocytopenia may increase the risk of bleeding, and the presence of neutropenia or leukopenia may increase the risk of infection.
Prisotnost trombocitopenije lahko poveča tveganje za krvavitev, prisotnost nevtropenije ali levkopenije pa lahko poveča tveganje za okužbo.
In clinical trials, the most frequently occurring treatment-related undesirable effects were gastrointestinal disorders, specifically nausea (43%) and vomiting (36%).
V kliničnih preskušanjih so bili najpogostejši z zdravljenjem povezani neželeni učinki prebavne motnje, še posebej navzea (43 %) in bruhanje (36 %).
The capsules contain lactose (a kind of sugar).
Kapsule vsebujejo majhno količino laktoze (vrsta sladkorja).
- if you have liver or kidney problems as your dose of temozolomide may need to be adjusted.
- Če imate težave z jetri ali ledvicami, ker bo morda treba prilagoditi vaš odmerek temozolomida.
• partial loss of vision, dry or painful eyes
• delna izguba vida, suhe ali boleče oči
If you are taking Temozolomide Accord capsules alone (without radiotherapy):
Če jemljete kapsule zdravila Temozolomid Accord same (brez radioterapije):
PHARMACEUTICAL FORM Hard capsule.
FARMACEVTSKA OBLIKA trde kapsule
In preclinical studies in rats and rabbits receiving 150 mg/m2, teratogenicity and/or foetal toxicity were demonstrated (see section 5.3).
V predkliničnih študijah pri podganah in kuncih, ki so prejemali 150 mg/m2, sta bili ugotovljeni teratogenost in/ali toksičnost za plod (glejte poglavje 5.3).
Results of the Ames/salmonella and Human Peripheral Blood Lymphocyte (HPBL) chromosome aberration tests showed a positive mutagenicity response.
Rezultati testa po Ames/Salmonella in testa kromosomskih aberacij v človeških limfocitih iz periferne krvi (HPBL - »Human Peripheral Blood Lymphocyte«) so pokazali pozitiven mutageni odziv.
However, all patients receiving TMZ, particularly patients receiving steroids, should be observed closely for the development of PCP, regardless of the regimen.
Vseeno pa je treba vse bolnike, ki prejemajo TMZ, še posebej tiste, ki prejemajo tudi steroide, skrbno spremljati zaradi možnosti pojava PCP ne glede na režim zdravljenja.
These reactions were usually Grade 1 or 2 (0 - 5 episodes of vomiting in 24 hours) and were either self-limiting or readily controlled with standard anti-emetic therapy.
Ti učinki so bili navadno stopnje 1 ali 2 (0-5 epizod bruhanja v 24 urah) in so izzveneli sami od sebe ali pa jih je bilo mogoče zlahka nadzorovati s standardnim antiemetičnim zdravljenjem.
Before each new treatment cycle, your blood will be tested to see if the temozolomide dose needs to be adjusted.
Pred začetkom vsakega cikla zdravljenja boste opravili preiskave krvi, da bi ugotovili ali je treba prilagoditi vaš odmerek temozolomida.
Your doctor will monitor your blood regularly for any changes, and will decide if any specific treatment is needed.
Vaš zdravnik bo redno preverjal vašo kri in zaradi morebitnih sprememb ter odločil, ali je potrebno kakšno posebno zdravljenje.
A total of 573 patients were randomised to receive either TMZ + RT (n=287) or RT alone (n=286).
Skupno 573 bolnikov je bilo randomiziranih v skupini, ki sta prejemali TMZ + RT (n=287) ali samo RT (n=286).
Male patients should use effective contraception and not father a child for up to 6 months after stopping treatment.
Moški bolniki morajo uporabljati učinkovito kontracepcijsko metodo in ne smejo spočeti otroka vsaj 6 mesecev po končanem zdravljenju.
- Be sure you know exactly which days are your dosing days.
- Prepričajte se, da res veste, katere dneve morate jemati odmerek.
nausea and vomiting).
slabosti in bruhanja).
However, since TMZ does not undergo hepatic metabolism and exhibits low protein binding, it is unlikely that it would affect the pharmacokinetics of other medicinal products (see section 5.2).
Ker se TMZ ne presnavlja v jetrih in izkazuje majhen obseg vezave na beljakovine, je malo verjetno, da bi vplival na farmakokinetiko drugih zdravil (glejte poglavje 5.2).
• Abnormal liver function tests,
• nenormalni rezultati testov jetrne funkcije
If you take more Temozolomide Accord than you should If you accidentally take more capsules than you were told to, contact your doctor, pharmacist or nurse immediately.
Če ste vzeli večji odmerek zdravila Temozolomid Accord, kot bi smeli Če po nesreči vzamete več kapsul, kot vam je bilo predpisano, se takoj posvetujte s svojim zdravnikom, farmacevtom ali medicinsko sestro.
Sometimes the dose or the mix of capsules you need to take will be different from the last cycle.
Včasih se bo odmerek oziroma kombinacija kapsul razlikovala od tiste, ki ste jo jemali v prejšnjem ciklu zdravljenja.