natgillin/translations-raw huggingface dataset:
The recommended dose is 50 mg taken as needed approximately one hour before sexual activity.
Priporočeni odmerek je 50 mg, uporabljen kot je potrebno, približno eno uro pred spolno dejavnostjo.
In order to get the maximum benefit from your medicine, it is recommended that you avoid alcohol before intake of this medicine.
Za najboljši učinek tega zdravila se priporoča, da pred jemanjem tega zdravila ne pijete alkohola.
Cardiovascular risk factors
Kardiovaskularni dejavniki tveganja
In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms.
Poleg tega morajo zdravniki bolnikom svetovati, kaj naj storijo v primeru simptomov posturalne hipotenzije.
It is not possible to determine whether these events were directly related to Sildenafil ratiopharm.
Ni mogoče določiti, ali so ti dogodki neposredno povezani z zdravilom Sildenafil ratiopharm.
In this case, he/she may decide to give you a lower dose.
Morda se bo odločil, da vam predpiše manjši odmerek.
Effect on bleeding
Vpliv na krvavitve
Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of sildenafil without sexual activity.
Za številne dogodke je bilo opisano, da so se zgodili med ali kmalu po spolnem odnosu, nekateri pa so se pojavili kmalu po uporabi sildenafila, brez spolne dejavnosti.
In order for sildenafil to be effective, sexual stimulation is required.
Da bi bil sildenafil učinkovit, je potrebna spolna stimulacija.
Very common (may affect more than 1 in 10 people): headache.
Zelo pogosti (pojavi se lahko pri več kot 1 od 10 bolnikov): glavobol.
Use in patients taking other medicinal products
Uporaba pri bolnikih, ki jemljejo druga zdravila
In clinical trials sildenafil was administered to more than 8,000 patients aged 19-87.
V kliničnih preskušanjih je sildenafil dobivalo več kot 8000 bolnikov, starih od 19 do 87 let.
It reduces the action of the natural chemical in your body, which makes erections go away.
Zmanjša delovanje naravne kemične snovi v telesu, ki ustavi erekcijo.
The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
V natisnjenem navodilu za uporabo zdravila mora biti navedena ime in naslov izdelovalca, odgovornega za sprostitev zadevne serije.
Further information on clinical trials
Dodatne informacije o kliničnih študijah
You should not take more film-coated tablets than your doctor tells you to.
Ne vzemite več filmsko obloženih tablet, kot vam je predpisal zdravnik.
The amount of time Sildenafil ratiopharm takes to work varies from person to person, but it normally takes between half an hour and one hour.
Čas, potreben za začetek delovanja zdravila Sildenafil ratiopharm, se od posameznika do posameznika razlikuje, a ponavadi traja od pol ure do eno uro.
- Prolonged and sometimes painful erections - this occurs rarely (may affect up to 1 in 1,000 people).
Podaljšana in včasih boleča erekcija - to se zgodi redko (pojavi se lahko pri največ 1 od 1.000 bolnikov).
Mean pulmonary systolic blood pressure decreased by 9%.
Srednji pljučni sistolični krvni tlak se je zmanjšal za 9 %.
Do not use nitrates to treat your chest pain.
• Ne vzemite nitratov, ki jih uporabljate za bolečine v prsnem košu.
This medicine will only help you to get an erection if you are sexually stimulated.
To zdravilo vam bo pomagalo doseči erekcijo samo, če ste spolno stimulirani.
The mean absolute oral bioavailability is 41% (range 25-63%).
Srednja absolutna peroralna biološka uporabnost je 41 % (razpon: od 25 do 63 %).
Swallow the film-coated tablet whole with a glass of water.
Filmsko obloženo tableto pogoltnite celo s kozarcem vode.
These reports included dizziness and light-headedness, but not syncope.
Ta poročila so obsegala omotico in rahlo vrtoglavico, ne pa sinkope.
If you are taking one of these medicines, your doctor may start you on the lowest dose (25 mg) of Sildenafil ratiopharm.
Če jemljete katero koli od teh zdravil, vam bo morda zdravnik na začetku predpisal najmanjši odmerek (25 mg) zdravila Sildenafil ratiopharm.
If this medicine does not help you to get an erection, or if your erection does not last long enough for you to complete sexual intercourse, you should tell your doctor.
Če vam to zdravilo ne pomaga doseči erekcije ali dosežena erekcija ne traja dovolj dolgo za popoln spolni odnos, morate to povedati zdravniku.
Due to the nitrate component it has the potential to result in a serious interaction with sildenafil.
Zaradi nitratne sestavine je možno, da povzroči resno medsebojno učinkovanje s sildenafilom.
- if you have a severe heart problem.
če imate težave s srcem.
The safety profile of sildenafil is based on 9,570 patients in 74 double-blind placebo-controlled clinical studies.
Varnostni profil sildenafila temelji na 9.570 bolnikih v 74 dvojno slepih, s placebom nadzorovanih kliničnih študijah.
Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined.
Ker imetniku dovoljenja za promet z zdravilom ne poročajo o vseh neželenih učinkih in le-ti niso zajeti v podatkovni bazi o varnosti, pogostnosti neželenih učinkov ne moremo zanesljivo določiti.
You should not take Sildenafil ratiopharm more than once a day.
Zdravila Sildenafil ratiopharm ne vzemite več kot enkrat na dan.
Of note, most, but not all, of the men who experienced these side effects had heart problems before taking this medicine.
Omeniti je treba, da je večina moških, ne pa vsi, ki so imeli te neželene učinke, imela težave s srcem že pred jemanjem tega zdravila.
These medicines are often used to relieve the symptoms of chest pain (angina pectoris).
Ta zdravila se pogosto uporabljajo za lajšanje simptomov bolečine v prsnem košu (angina pektoris).
In cases of overdose, standard supportive measures should be adopted as required.
V primeru prevelikega odmerjanja je treba uvesti standardno podporno zdravljenje.
Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment.
Pri takšnih bolnikih se sme sildenafil zato uporabiti le po skrbnem pretehtanju koristi in tveganj.
Pharmacokinetics in special patient groups Elderly
Farmakokinetika pri posebnih skupinah bolnikov
- A sudden decrease or loss of vision - this occurs rarely.
Nenadno poslabšanje ali izguba vida - to se zgodi redko.
Do not use this medicine after the expiry date which is stated on the outer carton and blister after EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na zunanji škatli in pretisnem omotu poleg oznake »EXP«.
The European Medicines Agency has waived the obligation to submit the results of studies with the reference medicinal product containing sildenafil in all subsets of the paediatric population for the treatment of erectile dysfunction (see section 4.2 for information on paediatric use).
Evropska agencija za zdravila je odstopila od zahteve za predložitev rezultatov študij za referenčno zdravilo, ki vsebuje sildenafil, za vse podskupine pediatrične populacije za zdravljenje erektilne disfunkcije (za podatke o uporabi pri pediatrični populaciji glejte poglavje 4.2).
Adverse reactions from post-marketing surveillance has been gathered covering an estimated period > 10 years.
Poročila o neželenih učinkih iz obdobja trženja pokrivajo obdobje več kot 10 let.
If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result.
Če se priapizem ne zdravi takoj, lahko pride do poškodbe tkiva penisa in stalne izgube spolne potence.
Sildenafil potentiates the hypotensive effect of nitrates (see section 4.3).
Sildenafil okrepi hipotenzivni učinek nitratov (glejte poglavje 4.3).
In a medical emergency, you must tell anyone treating you that you have taken Sildenafil ratiopharm.
Ob obisku nujne medicinske pomoči morate komur koli povedati, da ste vzeli zdravilo Sildenafil ratiopharm.
Sildenafil ratiopharm is indicated in adult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.
Zdravilo Sildenafil ratiopharm je indicirano pri odraslih moških z erektilno disfunkcijo, tj. nezmožnostjo doseči ali ohraniti erekcijo penisa, ki bi zadoščala za zadovoljivo spolno aktivnost.
When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%.
Če je sildenafil uporabljen s hrano, se stopnja absorpcije zmanjša s srednjo zakasnitvijo tmax 60 minut in srednjim zmanjšanjem Cmax za 29 %.
Based on efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg.
Glede na učinkovitost in prenašanje je odmerek mogoče zvečati na 100 mg ali zmanjšati na 25 mg.
The physiological mechanism responsible for erection of the penis involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation.
Fiziološki mehanizem, odgovoren za erekcijo penisa, vključuje sproščanje dušikovega oksida (NO) v corpus cavernosum med spolno stimulacijo.
Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue.
Sildenafil nima neposrednega relaksacijskega učinka na izoliran človeški corpus cavernosum, a močno okrepi relaksacijski učinek NO na to tkivo.
In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo.
V kontroliranih kliničnih preskušanjih je bil delež prekinitev zaradi sildenafila majhen in primerljiv s placebom.
Effects on vision
Učinki na vid
Your doctor should in that case carefully check whether your heart can take the additional strain of having sex.
V tem primeru mora zdravnik preveriti, ali lahko vaše srce prenese dodatno breme spolnega odnosa.
If you are taking ritonavir, you may not exceed a maximum dose of 25 mg sildenafil within a period of 48 hours.
Če jemljete ritonavir, morda ne boste smeli preseči največjega odmerka sildenafila 25 mg v 48 urah.
Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.
Pred začetkom kakršnega koli zdravljenja erektilne disfunkcije mora zdravnik preveriti kardiovaskularno stanje bolnika, saj je s spolno dejavnostjo povezana določena stopnja kardialnega tveganja.
Paediatric population Sildenafil ratiopharm is not indicated for individuals below 18 years of age.
Pediatrična populacija Zdravilo Sildenafil ratiopharm ni indicirano pri mlajših od 18 let.
As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to sildenafil, before driving or operating machinery.
V kliničnih preskušanjih s sildenafilom so poročali o omotici in spremembah vida, zato se morajo bolniki zavedati, kako se odzovejo na sildenafil, preden vozijo ali upravljajo s stroji.
These are symptoms of a fall in blood pressure upon rising quickly from sitting or lying (postural hypotension).
To so simptomi padca krvnega tlaka pri hitrem vstajanju iz sedečega ali ležečega položaja (ortostatska hipotenzija).
Patients should be advised that in the event of any sudden visual defect, they should stop taking sildenafil and consult a physician immediately (see section 4.3).
Bolnika je treba opozoriti, da naj v primeru kakršne koli nenadne okvare vida preneha jemati sildenafil in o tem nemudoma obvesti svojega zdravnika (glejte poglavje 4.3).
A double-blind, placebo-controlled exercise stress trial evaluated 144 patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products (except nitrates).
Dvojno slepa, s placebom nadzorovana študija z obremenitvenim testiranjem pri 144 bolnikih z erektilno disfunkcijo in kronično stabilno angino pektoris, ki so redno prejemali zdravila za zdravljenje angine pektoris (razen nitratov).
If you have an erection, which lasts for more than 4 hours, you should contact a doctor immediately.
Če imate erekcijo, ki traja dlje kot 4 ure, se morate nemudoma posvetovati z zdravnikom.
At 24 hours, the plasma levels of sildenafil were still approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was administered alone.
Po 24 urah je bila koncentracija sildenafila v plazmi še vedno približno 200 ng/ml v primerjavi s približno 5 ng/ml v primeru, ko je bil sildenafil apliciran sam.
Given sildenafil peak plasma concentrations of approximately 1 µM after recommended doses, it is unlikely that sildenafil will alter the clearance of substrates of these isoenzymes.
Ker je največja koncentracija sildenafila v plazmi po priporočenih odmerkih približno 1 μM, ni verjetno, da bi sildenafil spremenil očistek substratov teh izoencimov.
Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance.
Zaviralci teh izoencimov zato lahko zmanjšajo očistek sildenafila, induktorji teh encimov pa lahko zvišajo očistek sildenafila.
Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction
Sočasna uporaba z drugimi zaviralci PDE5 ali drugimi zdravili za zdravljenje erektilne disfunkcije
What Sildenafil ratiopharm is and what it is used for What you need to know before you take Sildenafil ratiopharm How to take Sildenafil ratiopharm Possible side effects
Kaj je zdravilo Sildenafil ratiopharm in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Sildenafil ratiopharm Kako jemati zdravilo Sildenafil ratiopharm Možni neželeni učinki
- Serious skin reactions - this occurs rarely.
Resne kožne reakcije - to se zgodi redko.
From post-marketing experience cases of unstable angina (a heart condition) and sudden death have been reported rarely.
V obdobju trženja so redko poročali o nestabilni angini pektoris (bolezen srca) in nenadni smrti.
These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle.
To znižanje krvnega tlaka je skladno z vazodilatacijskimi učinki sildenafila in je verjetno posledica zvišanja ravni cGMP v žilnem gladkem mišičju.
Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects.
Pri močnejših zaviralcih CYP3A4, npr. pri ketokonazolu in itrakonazolu, bi lahko pričakovali močnejše učinke.
Table 1: Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through postmarketing surveillance
Preglednica 1: Medicinsko pomembni neželeni učinki, o katerih so v nadzorovanih kliničnih študijah poročali z večjo pogostnostjo kot pri placebu, in medicinsko pomembni neželeni učinki, o katerih so poročali v postmarketinškem nadzoru.
This medicine is used to treat pulmonary arterial hypertension (i.e. high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e. high blood pressure in the lungs secondary to blood clots).
To zdravilo se uporablja za zdravljenje pljučne arterijske hipertenzije (tj. visokega krvnega tlaka v pljučih) in kronične trombembolične pljučne hipertenzije (tj. visokega krvnega tlaka v pljučih, ki nastane zaradi krvnih strdkov).
In these study populations, mean additional reductions of supine blood pressure of 7/7 mmHg, 9/5 mmHg, and 8/4 mmHg, and mean additional reductions of standing blood pressure of 6/6 mmHg, 11/4 mmHg, and 4/5 mmHg, respectively, were observed.
V teh študijskih populacijah so opažali povprečno dodatno znižanje krvnega tlaka leže za 7/7 mmHg, 9/5 mmHg in 8/4 mmHg ter dodatno znižanje krvnega tlaka stoje za 6/6 mmHg, 11/4 mmHg in 4/5 mmHg.
Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process.
Študije in vitro so pokazale, da je sildenafil selektiven za PDE5, ki je vpletena v erekcijsko dogajanje.
Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state.
Največjo koncentracijo v plazmi doseže v 30 do 120 minutah (mediano v 60 minutah) po peroralni uporabi na prazen želodec.
Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation.
Dve klinični študiji sta bili posebej namenjeni oceni časa, v katerem lahko sildenafil po uporabi odmerka kot odziv na spolno stimulacijo povzroči erekcijo.
Sildenafil ratiopharm will only work when you are sexually stimulated.
Zdravilo Sildenafil ratiopharm bo delovalo samo, če ste spolno stimulirani.
- if you suffer from any of the following disorders, please tell your doctor who will check carefully whether this medicine is suitable for you: if you currently have a stomach ulcer; if you have a blood-clotting disorder (e.g. haemophilia).
če imate katero koli od naslednjih motenj, se posvetujte z zdravnikom, ki bo skrbno preveril, ali je to zdravilo ustrezno za vas: če imate želodčno razjedo (ulkus), če imate motnjo strjevanja krvi (npr. hemofilijo);
Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of cGMP.
Sildenafil je močan in selektiven zaviralec za cGMP specifično fosfodiesterazo tipa 5 (PDE5) v corpusu cavernosumu, kjer PDE5 razgrajuje cGMP.
Sildenafil had no effect on ritonavir pharmacokinetics.
Sildenafil ne vpliva na farmakokinetiko ritonavirja.
Do NOT take Sildenafil ratiopharm: - if you are allergic to sildenafil or any of the other ingredients of this medicine (listed in section
NE jemljite zdravila Sildenafil ratiopharm: če ste alergični na sildenafil ali katero koli sestavino tega zdravila (navedeno v poglavju 6).
- if you do not have erectile dysfunction.
če nimate erektilne disfunkcije, če ste ženska.
The dosing recommendations described in ‘Use in adults' apply to patients with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min).
Priporočila za odmerjanje, opisana pri "Uporaba pri odraslih", veljajo tudi za bolnike z blago do zmerno okvaro ledvic (očistek kreatinina = 30 do 80 ml/min).
If you experience sudden decrease or loss of vision, stop taking Sildenafil ratiopharm and contact your doctor IMMEDIATELY.
Če se pojavi nenadno poslabšanje ali izguba vida, prenehajte jemati zdravilo Sildenafil ratiopharm in se TAKOJ posvetujte z zdravnikom.
- An allergic reaction - this occurs uncommonly (may affect up to 1 in 100 people).
Alergijska reakcija - to se zgodi občasno (pojavi se lahko pri največ 1 od 100 bolnikov).
Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects.
Sildenafil povzroči blago in prehodno znižanje krvnega tlaka, ki večinoma nima kliničnih učinkov.
After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL (CV 40%).
Po enkratnem 100-mg peroralnem odmerku je srednja največja celotna koncentracija sildenafila v plazmi približno 440 ng/ml (CV 40 %).
Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects.
Zato je za dosego želenih farmakoloških učinkov sildenafila potrebna spolna stimulacija.
Single oral doses of sildenafil up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG.
Enkratni peroralni odmerek sildenafila do 100 mg pri zdravih prostovoljcih ni povzročil klinično pomembnih sprememb na EKG.
If you take more Sildenafil ratiopharm than you should Men who take too much Sildenafil ratiopharm may experience more side effects or may get severe muscle pain.
Če ste vzeli večji odmerek zdravila Sildenafil ratiopharm, kot bi smeli Moški, ki vzamejo preveč zdravila Sildenafil ratiopharm, imajo lahko več neželenih učinkov ali hudo bolečino v mišicah.
Therefore, concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma concentrations of sildenafil.
Zato je pri sočasni uporabi močnih induktorjev CYP3A4, kot je rifampin, pričakovati, da bo povzročil večje znižanje plazemske koncentracije sildenafila.
Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity.
Preden zdravnik predpiše sildenafil, mora natančno pretehtati, ali bi lahko takšni vazodilatacijski učinki neželeno vplivali na bolnike, ki imajo določene bolezni, zlasti v kombinaciji s spolno dejavnostjo.
Simultaneous intake of nitrates or nitric oxide donors with Sildenafil ratiopharm can have severe effects on your blood pressure.
Sočasno jemanje nitratov ali donorjev dušikovega oksida z zdravilom Sildenafil ratiopharm ima lahko resne učinke na krvni tlak.
- if you suffer from kidney or liver problems.
če imate težave z ledvicami ali jetri.
The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina.
Rezultati niso dokazali klinično pomembnih razlik pri sildenafilu v primerjavi s placebom v času do pojava omejujoče angine pektoris.
Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 > 150 µM).
Sildenafil je šibek zaviralec izoencimov 1A2, 2C9, 2C19, 2D6, 2E1 in 3A4 citokroma P450 (IC50 > 150 μM).
PDE5 inhibitors, such as sildenafil, have been shown to increase the hypotensive effects of this medicine.
Zaviralci PDE5, kot je sildenafil, dokazano povečujejo hipotenzivne učinke tega zdravila.
The following groups were not well represented or excluded from clinical trials: patients with pelvic surgery, patients post-radiotherapy, patients with severe renal or hepatic impairment and patients with certain cardiovascular conditions (see section 4.3).
Naslednje skupine niso bile zadovoljivo zastopane ali so bile izključene iz kliničnih preskušanj: bolniki po operacijah na medenici, po radioterapiji, s hudo ledvično ali jetrno okvaro in bolniki z nekaterimi kardiovaskularnimi motnjami (glejte poglavje 4.3).
If you take more Sildenafil ratiopharm than you should, tell your doctor.
Če ste vzeli večji odmerek zdravila Sildenafil ratiopharm, kot bi smeli, se posvetujte z zdravnikom.
The mean steady state volume of distribution (Vd) for sildenafil is 105 l, indicating distribution into the tissues.
Srednji volumen porazdelitve (Vd) sildenafila v stanju dinamičnega ravnovesja je 105 l, kar kaže, da se porazdeli v tkiva.
Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro.
Študije s človeškimi trombociti kažejo, da sildenafil okrepi antiagregacijski učinek natrijevega nitroprusida in vitro.
The corresponding change in supine diastolic blood pressure was 5.5 mmHg.
Ustrezna sprememba diastoličnega krvnega tlaka leže je bila 5,5 mmHg.
Since sildenafil (and its major circulating N-desmethyl metabolite) is 96% bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/mL (38 nM).
Ker je sildenafil (in njegov glavni krožeči N-desmetilni presnovek) 96 % vezan na beljakovine v plazmi, je srednja največja koncentracija prostega sildenafila v plazmi 18 ng/ml (38 nM).
Other medicines and Sildenafil ratiopharm Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Druga zdravila in zdravilo Sildenafil ratiopharm Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katero koli drugo zdravilo.
In fixed dose studies, the proportions of patients reporting that treatment improved their erections were 62% (25 mg), 74% (50 mg) and 82% (100 mg) compared to 25% on placebo.
V preskušanjih z vnaprej določenim odmerkom je bil delež bolnikov, ki so navajali, da jim je zdravilo izboljšalo erekcije, 62 % (25 mg), 74 % (50 mg) oz. 82 % (100 mg) v primerjavi s 25 % pri bolnikih s placebom.