natgillin/translations-raw huggingface dataset:
If you develop these symptoms, stop taking Iasibon and tell your doctor straight away (see sections 3 and 4).
Če se pojavijo ti simptomi, prenehajte z jemanjem zdravila Iasibon in takoj obvestite svojega zdravnika (glejte poglavji 3 in 4).
They are available in packs of 3, 6, 9, 28 and 84 tablets.
Na voljo so v pakiranjih po 3, 6, 9, 28 in 84 tablet.
Multiple events were therefore counted only once for the purposes of the analysis.
Večkratne dogodke so zaradi analize upoštevali le enkrat.
If the dates for submission of a PSUR and the update of a RMP coincide, they can be submitted at the same time.
Če predložitev PSUR in posodobitev RMP sovpadata, se ju lahko predloži istočasno.
Film-coated tablets 3 film-coated tablets 6 film-coated tablets 9 film-coated tablets 28 film-coated tablets 84 film-coated tablets
Filmsko obložene tablete 3 filmsko obložene tablete 6 filmsko obloženih tablet 9 filmsko obloženih tablet 28 filmsko obloženih tablet 84 filmsko obloženih tablet
• Swallow the tablet whole.
• pogoltnete celo tableto.
If you are taking a tablet every other day or once a week, ask your doctor or pharmacist for advice.
Če jemljete tablete vsak drugi dan ali enkrat na teden, vprašajte vašega zdravnika ali farmacevta za nasvet.
When taken 30 minutes before a meal, the reduction in bioavailability is approximately 30%.
Pri jemanju 30 minut pred obrokom je zmanjšanje biološke uporabnosti približno 30-%.
500 ml over 1 hour
500 ml v 1 uri
Maximum observed plasma concentrations were reached within 0.5 to 2 hours (median 1 hour) in the fasted state and absolute bioavailability was about 0.6%.
Najvišje plazemske koncentracije so bile med postom dosežene v obdobju od 0,5 do 2 ur (mediana časa 1 ura), absolutna biološka uporabnost je bila okoli 0,6 %.
SMPR (per patient year)
SMPR (na bolnikovo leto)
• rise in body temperature.
• zvišanje telesne temperature,
Hypromellose (E464) Titanium dioxide E171
Hipromeloza (E464) Titanov dioksid (E171)
The extent of absorption is impaired when taken together with food or beverages (other than water).
Obseg absorpcije je pri sočasnem jemanju hrane ali pijače (druge kot voda) zmanjšan.
If anaphylactic or other severe hypersensitivity/allergic reactions occur, immediately discontinue the injection and initiate appropriate treatment.
Če pride do pojava anafilaktične ali druge hude preobčutljivostne/alergijske reakcije, takoj prekinite z injiciranjem in začnite z ustreznim zdravljenjem.
As renal function decreases with age, this is the only factor that should be considered (see renal impairment section).
Ker se ledvična funkcija z leti zmanjšuje, je to edini dejavnik, ki ga je treba upoštevati (glejte odstavek ledvične okvare).
However, the marketing authorisation holder shall submit periodic safety update reports for this medicinal product if the product is included in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal.
• Redno posodobljena poročila o varnosti zdravila (PSUR) Imetnik dovoljenja za promet z zdravilom mora redno posodobljena poročila o varnosti zdravila za to zdravilo predložiti v skladu z zahtevami, določenimi v seznamu referenčnih datumov Unije (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES in objavljenem na evropskem spletnem portalu o zdravilih.
A limited number of patients (50 patients) have received a second infusion for hypercalcaemia.
Omejeno število bolnikov (50 bolnikov) je prejelo drugo infuzijo zaradi hiperkalciemije.
Creatinine Clearance (ml/min)
Očistek kreatinina (ml/min)
In particular, tell your doctor or pharmacist if you are taking any of the following medicines:
Še posebej obvestite svojega zdravnika ali farmacevta, če jemljete katerekoli izmed naslednjih zdravil:
Iasibon is indicated in adults for:
4.1 Terapevtske indikacije Iasibon je indiciran pri odraslih za:
• Do not use this medicine if you notice that the solution is not clear or contains particles.
• Ne uporabljajte tega zdravila ,če opazite, da raztopina ni bistra ali vsebuje vidne delce.
Do not lie down.
Ne izzovite bruhanja in ne lezite.
• increased sensitivity of sound, taste or touch or changes in smell
• povečana občutljivost na zvok, okus ali dotik ali spremembe zaznavanja vonja,
Water may be taken at any time during the course of Iasibon treatment (see section 4.5).
Vodo lahko med zdravljenjem z zdravilom Iasibon pijemo kadarkoli (glejte poglavje 4.5).
• supplements containing calcium, magnesium, iron or aluminium
• dodatke, ki vsebujejo kalcij, magnezij, železo ali aluminij;
- The tablets should be swallowed whole with a full glass of water (180 to 240 ml) while the patient is standing or sitting in an upright position.
- Tablete je treba pogoltniti cele s polnim kozarcem navadne vode (180 do 240 ml), bolnik mora pri tem stati ali sedeti pokončno.
After taking your tablet, wait at least 30 minutes.
ko vzamete tableto, počakajte vsaj 30 minut.
Not known (frequency cannot be estimated from the available data) • asthma attack
Ni znano (pogostnosti ni mogoče oceniti iz razpoložljivih podatkov):
• Iasibon is normally given by a doctor or other medical staff who have experience with the treatment of cancer.
• Zdravilo Iasibon običajno aplicira zdravnik ali drugo medicinsko osebje, ki ima izkušnje pri zdravljenju raka..
The highest dose used in clinical trials was 6 mg but this dose does not add any further benefit in terms of efficacy.
Največji odmerek, ki so ga dajali v kliničnih preskušanjih, je bil 6 mg, vendar ta odmerek ni prispeval k nadaljnjemu izboljšanju glede učinkovitosti.
Repeated treatment may be considered in case of recurrent hypercalcaemia or insufficient efficacy.
Ponovitev zdravljenja pride v poštev v primeru povratne hiperkalciemije ali nezadostne učinkovitosti.
Renal clearance (about 60 ml/min in healthy postmenopausal females) accounts for 50-60% of total clearance and is related to creatinine clearance.
Ledvični očistek (okoli 60 ml/min pri zdravih ženskah v postmenopavzi) znaša okoli 50 do 60 % celotnega očistka in je soroden kreatininskemu očistku.
Iasibon tablets should be taken after an overnight fast (at least 6 hours) and before the first food or drink of the day.
Tablete Iasibon je treba vzeti po postu prek noči (najmanj 6 ur) pred prvim zaužitjem hrane ali pijače v dnevu.
• if you are allergic to any other bisphosphonates
• če ste alergični na druge difosfonate;
Products containing calcium and other multivalent cations (such as aluminium, magnesium, iron), including milk and food, are likely to interfere with absorption of Iasibon tablets.
Pripravki, ki vsebujejo kalcij in druge večvalentne katione (kot so aluminij, magnezij, železo), vključno z mlekom in hrano, lahko vplivajo na absorpcijo tablet Iasibon.
Multiple events were therefore, counted only once in any given 12 week period for the purposes of the analysis.
Večkratni dogodki so bili za namen analize upoštevani le enkrat v kateremkoli 12-tedenskem obdobju.
Diagnosis of cancer, chemotherapy, radiotherapy, corticosteroids and poor oral hygiene are also deemed as risk factors (see section 4.4).
Rak, kemoterapija, radioterapija, kortikosteroidi in slaba ustna higiena se prav tako štejejo za dejavnike tveganja (glejte poglavje 4.4).
In humans, the apparent terminal volume of distribution is at least 90 l and the amount of dose reaching the bone is estimated to be 40-50% of the circulating dose.
Pri ljudeh znaša navidezni terminalni volumen porazdelitve najmanj 90 l, količina odmerka, ki doseže kosti, je ocenjena na 40 do 50 % odmerka, ki je v krvnem obtoku.
Iasibon with food and drink
Zdravilo Iasibon skupaj s hrano in pijačo
If you experience one of the following symptoms, such as shortness of breath/difficulty breathing, tight feeling in throat, swelling of tongue, dizziness, feeling of loss of consciousness, redness or swelling of face, body rash, nausea and vomiting, you should immediately alert your doctor or nurse (see section 4).
Če se pri vas pojavi eden izmed naslednjih simptomov, kot je kratka sapa/težko dihanje, utesnjen občutek v grlu, otekel jezik, omotica, občutek izgube zavesti, rdečica ali zatekanje obraza, izpuščaj po telesu, slabost in bruhanje, morate nemudoma obvestiti svojega zdravnika ali medicinsko sestro (glejte poglavje 4).
• ear pain, discharge from the ear, and/or an ear infection.
• bolečine v ušesu, izcedka iz ušesa in/ali okužbe ušesa.
• injury or pain at the injection site
• bolečina ali poškodba na mestu injiciranja,
For these patients and dosages, the median time to achieve normocalcaemia was 4 to 7 days.
Za te bolnike je bila pri teh odmerkih mediana časa do normokalciemije 4 do 7 dni.
Bisphosphonates act by inhibiting osteoclast activity, although the precise mechanism is still not clear.
Difosfonati zavirajo osteoklastno aktivnost, natančni mehanizem pa še vedno ni jasen.
The content of the vial is to be used as follows:
Vsebino viale je treba uporabiti na naslednji način:
Attention should also be paid to the possible existence of simultaneous hypomagnesaemia.
Pozorni moramo biti tudi na možnost razvoja hipomagneziemije.
In most cases no specific treatment was required and the symptoms subsided after a couple of hours/days.
V večini primerov posebno zdravljenje ni bilo potrebno in simptomi so izveneli po nekaj urah/dneh.
Total clearance of ibandronic acid is low with average values in the range 84-160 ml/min.
Skupni očistek ibandronske kisline je nizek, povprečna vrednost znaša od 84 do 160 ml/min.
Taking medicines that reduce stomach acid such as cimetidine and ranitidine, may slightly increase the effects of Iasibon.
Jemanje zdravil, ki znižujejo količino kisline v želodcu, kot sta cimetidin in ranitidin, lahko rahlo povečajo učinek zdravila Iasibon.
No data are available (see section 5.1 and 5.2).
Podatki niso na voljo (glejte poglavji 5.1 in 5.2).
• pain in your nerves, damaged nerve root
• bolečine v živcih, poškodbe živčnih korenov,
Ibandronic acid belongs to the bisphosphonate group of compounds which act specifically on bone.
Ibandronska kislina pripada skupini difosfonatov, ki specifično delujejo na kosti.
In particular, tell your doctor or pharmacist if you are receiving a type of antibiotic injection called ‘aminoglycoside' such as gentamicin.
Še posebej obvestite svojega zdravnika ali farmacevta, če jemljete antibiotik v obliki injekcije iz skupine aminoglikozidov, kot je gentamicin.
You may be having a serious, potentially life threatening allergic reaction (see section 2).
Lahko imate resno, morda življenjsko ogrožujočo alergijsko reakcijo (glejte poglavje 2).
For patients requiring dental procedures, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of osteonecrosis of the jaw.
Za bolnike, pri katerih je potreben zobozdravstveni poseg, ni na voljo podatkov o tem, ali prekinitev zdravljenja z difosfonati zmanjša tveganje za osteonekrozo čeljustnic.
• If you have heart problems and the doctor recommended to limit your daily fluid intake
• če imate težave s srcem in vam je zdravnik priporočil, da omejite dnevni vnos tekočin.
The absorbed fraction of ibandronic acid is removed from the circulation via bone absorption (estimated to be 40-50%) and the remainder is eliminated unchanged by the kidney.
Absorbiran delež ibandronske kisline se iz sistemskega krvnega obtoka odstrani z absorpcijo v kostno tkivo (predvidoma 40 do 50 %), preostanek pa se nespremenjen izloči skozi ledvice.
• itching or tingling skin around your mouth
• srbenje ali ščemenje kože okoli ust,
• acetylsalicylic acid and non-steroidal anti-inflammatory medicines called “NSAIDs”, such as, ibuprofen or naproxen.
• acetilsalicilno kislino ali nesteroidna protivnetna zdravila, imenovana NSAID, kot so,, ibuprofen ali naproksen.
Effects in non-clinical studies were observed only at exposures sufficiently in excess of the maximum human exposure indicating little relevance to clinical use.
Predklinične učinke so opazili samo pri izpostavljenosti, ki je močno presegala največjo izpostavljenost pri človeku, kar kaže na majhen pomen za klinično uporabo.
Take Iasibon at least 6 hours after you had last had anything to eat, drink or any other medicines or supplements (e.g. products containing calcium (milk), aluminium, magnesium and iron) except water.
Vzemite zdravilo Iasibon vsaj 6 ur po vašem zadnjem zaužitem obroku, pijači, kateremkoli zdravilu ali dodatku (to so zdravila, ki vsebujejo kalcij (mleko), aluminij, magnezij in železo), razen vodi.
10vials
10 vial
Due to the risk of oesophageal irritation, vomiting should not be induced and the patient should remain fully upright.
Zaradi možnosti vzdraženja ezofagusa bruhanja ne smemo izzvati, bolnik pa mora ostati v povsem pokončnem položaju.
Talk to a nurse or doctor if any effects become troublesome or last more than a couple of days
Posvetujte se z medicinsko sestro ali zdravnikom, če ti neželeni učinki postanejo hujši ali če trajajo več kot nekaj dni;
The results from this trial are summarised below.
Izsledki tega preskušanja so povzeti spodaj.
• if you have kidney problems.
• če imate ledvične težave.
1 0.9% sodium chloride solution or 5% glucose solution 2 Administration every 3 to 4 week
1 0,9-% raztopina natrijevega klorida ali 5-% raztopina glukoze 2 aplikacija vsake 3 do 4 tedne
Irritation, inflammation or ulceration of the gullet/food pipe (oesophagus) often with symptoms of severe pain in the chest, severe pain after swallowing food and/or drink, severe nausea, or vomiting may occur, especially if you do not drink a full glass of water and/or if you lie down within an hour of taking Iasibon.
Lahko se pojavijo draženje, vnetje ali razjede v požiralniku (ezofagusu), pogosto s simptomi hude bolečine v prsih, hude bolečine po požiranju hrane in/ali pijače, hudo slabostjo in bruhanjem, še posebno, če ne popijete celega kozarca vode in/ali se uležete v eni uri po jemanju zdravila Iasibon.
In general patients with osteolytic bone metastases require lower doses than patients with the humoral type of hypercalcaemia.
V splošnem potrebujejo bolniki z osteolitičnimi metastazami v kosteh manjše odmerke kot bolniki s humoralnim tipom hiperkalciemije.
• tablet coat: titanium dioxide (E171), lactose monohydrate, hypromellose (E464), macrogol 4000
• Obloga tablet: titanov dioksid (E171), laktoza monohidrat, hipromeloza(E464), makrogol
Otherwise, some of the medicine could leak back into your food pipe/gullet (oesophagus)
Drugače lahko nekaj zdravila preide nazaj v vaš požiralnik (ezofagus).
Diluted solutions are for single use.
Razredčene raztopine so za enkratno uporabo.
In most cases a raised serum calcium level can be reduced to the normal range within 7 days.
V večini primerov lahko zvišane koncentracije kalcija v serumu znižamo na normalno vrednost v 7 dneh.
Elderly population (> 65 years) No dose adjustment is required (see section 5.2).
Starejša populacija (> 65 let) Prilagajanje odmerkov ni potrebno (glejte poglavje 5.2).
that is bleeding, or that your stomach is inflamed (gastritis)
krvavi ali da je želodec vnet (gastritis).
Mean Cmax was not increased in patients with mild renal impairment and increased by 12% in patients with moderate renal impairment.
Povprečna Cmax se pri bolnikih z blago ledvično okvaro ni povečala, pri bolnikih z zmerno ledvično okvaro pa se je povečala za 12 %.
Analgesic use *
Uporaba analgezije *
• if you have, or have ever had low levels of calcium in your blood.
• če imate ali ste kadarkoli imeli nizke koncentracije kalcija v krvi.
• feeling thirsty, sore throat, changes in taste
• občutek žeje, vneto grlo, spremenjen okus,
• severe adverse skin reactions
• hude neželene kožne reakcije.
The secretory pathway of renal elimination does not appear to include known acidic or basic transport systems involved in the excretion of other active substances.
Poti izločanja ne vključujejo znanih kislinskih ali bazičnih transportnih sistemov, ki sodelujejo pri izločanju drugih zdravilnih učinkovin.
If you have been told by your doctor that you cannot tolerate or digest some sugars (e.g. if you have a galactose intolerance, the Lapp lactase deficiency or have problems with glucose-galactose absorption), talk to your doctor before taking this medicine.
Če vam je zdravnik povedal, da ne prenašate ali prebavljate nekaterih sladkorjev (ne prenašate galaktoze, imate laponsko obliko zmanjšane aktivnosti laktaze ali težave z absorpcijo glukoze in galaktoze), se pred jemanjem tega zdravila posvetujte z vašim zdravnikom.
In a multivariate analysis, age was not found to be an independent factor of any of the pharmacokinetic parameters studied.
Večvariantna analiza je pokazala, da starost med vsemi preizkušanimi farmakokinetičnimi parametri ni neodvisen dejavnik.
• if you are having dental treatment or surgery or know that you need some in the future, tell your dentist that you are being treated with Iasibon for cancer
• če se zdravite zaradi bolezni zob ali ste imeli operacijo zob oziroma boste kaj od tega potrebovali v prihodnosti, povejte svojemu zobozdravniku, da se zdravite z zdravilom Iasibon zaradi raka.
LIST OF EXCIPIENTS The tablets also contain lactose.
SEZNAM POMOŽNIH SNOVI Tablete vsebujejo tudi laktoze.
You may be having a serious, potentially life threatening allergic reaction
Lahko imate resno, morda življenjsko ogrožujočo alergijsko reakcijo.
If you take more Iasibon than you should
Če ste vzeli večji odmerek zdravila Iasibon, kot bi smeli
In a study in 130 patients with metastatic breast cancer the safety of Ibandronate infused over 1 hour or 15 minutes was compared.
V študiji so pri 130 bolnikih z metastatskim rakom dojke primerjali varnost dajanja infuzije ibandronske kisline v času več kot 1 uro z dajanjem v času 15 minut.
They include a decreased number of implantation sites, interference with natural delivery (dystocia), an increase in visceral variations (renal pelvis ureter syndrome) and teeth abnormalities in F1 offspring in rats.
Vključujejo zmanjšano število vsaditvenih mest, motnje naravnega poroda (distocija), zvečano število visceralnih sprememb, pieloureterni sindrom in nepravilnosti zob pri potomcih podgan F1.
This reduction in urinary CTx levels was significantly correlated with the primary efficacy endpoint SMPR (Kendall-tau-b (p<0.001)).
Znižanje koncentracij CTx v seču je bilo značilno v korelaciji s primarnim ciljem raziskave učinkovitosti SMPR (Kendall-tau-b (p < 0,001)).
Injury, poisoning and procedural complications
Poškodbe in zastrupitve in zapleti pri poškodba,
• if you are allergic to ibandronic acid or any of the other ingredients of this medicine that are listed in section 6
• če ste alergični na ibandronsko kislino ali katerokoli sestavino tega zdravila, navedeno v poglavju
• pain in your bone or muscles
• bolečina v kosteh ali mišicah,
- Patients should not chew, suck or crush the tablet because of a potential for oropharyngeal ulceration.
- Bolniki tablet ne smejo žvečiti, sesati ali drobiti, ker se lahko pojavi ulceracija žrela.
There are no adequate data from the use of ibandronic acid in pregnant women.
Ni zadostnih podatkov o uporabi ibandronske kisline pri nosečnicah.
The difference between the apparent total and renal clearances is considered to reflect the uptake by bone.
Razlika med navideznim celokupnim in ledvičnim očistkom kaže prevzem v kostno tkivo.
If there is concern regarding potentially high levels of calcium in the tap water (hard water), it is advised to use bottled water with a low mineral content.
Če obstaja skrb, da je v vodi iz pipe visok delež kalcija (trda voda), je pripočljivo uporabljati ustekleničeno vodo z nizko vsebnostjo mineralov.
Iasibon 50 mg film coated tablets are supplied in Polyamide/Al/PVC - Aluminum foil blister with 3, 6, 9, 28 or 84 tablets, packaged in a cardboard box.
Filmsko obložene tablete Iasibon 50 mg so pakirane v pretisnih omotih (poliamid/Al/PVCaluminijasto folija) po 3, 6, 9, 28 ali 84 tablet, na voljo so v škatlah.
Patients should pay particular attention and be able to comply with the dosing instructions (see section 4.2).
Bolniki morajo biti posebej pozorni in zdravilo jemati v skladu z navodili za odmerjanje (glejte poglavje 4.2).
The risk of severe oesophageal adverse experiences appears to be greater in patients who do not comply with the dosing instruction and/or who continue to take oral bisphosphonates after developing symptoms suggestive of oesophageal irritation.
Zdi se, da je tveganje za nastanek hudih neželenih dogodkov na ezofagusu večje pri bolnikih, ki zdravila ne jemljejo v skladu z navodili za odmerjanje in/ali tistih, ki nadaljujejo z jemanjem peroralnih difosfonatov tudi po pojavu simptomov, ki kažejo na draženje ezofagusa.
Contains 0.86 mg lactose (as lactose monohydrate).
Vsebuje 0.86 mg laktoze (v obliki laktoze monohidrata).
The majority of the reports refer to cancer patients, but such cases have also been reported in patients treated for osteoporosis.
Večina primerov je bila pri bolnikih z rakom, vendar tudi pri bolnikih, ki so se zdravili zaradi osteoporoze.
• stomach problems such as ‘gastroenteritis' or ‘gastritis'
• težave z želodcem, kot sta gastroenteritis in gastritis,
In subjects with severe renal impairment (mean estimated CLcr = 21.2 mL/min), dose-adjusted mean AUC0-24h was increased by 110% compared to healthy volunteers.
Pri ljudeh s hudo ledvično okvaro (ocenjeno povprečje CLcr = 21,2 ml/min) se je povprečna vrednost AUC0-24 glede na odmerek povečala za 110 % v primerjavi z zdravimi prostovoljci.
If you stop taking Iasibon
Če ste prenehali jemati zdravilo Iasibon
PHARMACEUTICAL FORM AND CONTENTS Concentrate for solution for infusion 1 ampoule
FARMACEVTSKA OBLIKA IN VSEBINA koncentrat za raztopino za infundiranje 1 ampula
Treatment of tumour induced hypercalcaemia is most frequently associated with a rise in body temperature.
Zdravljenje tumorsko povzročene hiperkalciemije je najpogosteje povezano z zvišanjem telesne temperature.
- Treatment of tumour-induced hypercalcaemia with or without metastases
• zdravljenje tumorsko povzročene hiperkalciemije z metastazami ali brez njih.
In most cases no specific treatment is required and the symptoms subside after a couple of hours/days.
V večini primerov posebno zdravljenje ni potrebno, simptomi izginejo po nekaj urah ali dneh.
Treatment of tumour-induced hypercalcaemia
Zdravljenje tumorsko povzročene hiperkalciemije
If you take too many tablets talk to a doctor or go to hospital straight away.
Če ste vzeli večji odmerek, se posvetujte z zdravnikom ali pojdite takoj v bolnišnico.
If you forget to take Iasibon
Če ste pozabili vzeti zdravilo Iasibon
In the prevention of skeletal events in patients with breast cancer and bone metastases, treatment is most frequently associated with asthenia followed by rise in body temperature and headache.
Pri preprečevanju z okostjem povezanih dogodkov pri bolnikih z rakom dojke in metastazami v kosteh je bilo zdravljenje najpogosteje povezano z astenijo, ki ji je sledilo zvišanje telesne temperature in glavobol.
The median time to relapse was 26 days with a dose of 6 mg.
Mediana časa do relapsa pri odmerku 6 mg je bila 26 dni.
• if you have high or low levels of vitamin D, calcium or any other minerals
• če imate visoke ali nizke koncentracije vitamina D, kalcija ali drugih mineralov;
No difference was observed in the indicators of renal function.
Pri kazalcih ledvične funkcije razlik niso opazili.
The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch
V natisnjenem navodilu za uporabo zdravila mora biti navedeno ime in naslov izdelovalca,
Consideration should be given to the severity of the hypercalcaemia as well as the tumour type.
Presoditi je treba o stopnji hiperkalciemije in tudi o tipu tumorja.
Take your tablet at least 6 hours after you had last had anything to eat, drink or any other medicines or supplements except water.
Vzemite vašo tableto vsaj 6 ur po vašem zadnjem zaužitem obroku, pijači, kateremkoli zdravilu ali dodatku razen vodi.