natgillin/translations-raw huggingface dataset:
It is not known if Natpar has any effects on fertility.
Ni znano, ali ima zdravilo Natpar kakršne koli učinke na plodnost.
It is strongly recommended that every time you receive a dose of Natpar, the name and batch number of the product are recorded in order to maintain a record of the batches used.
Zelo priporočljivo je, da se ob vsakem odmerku zdravila Natpar, ki ga prejmete, zapišeta ime in številka serije zdravila za vodenje evidence uporabljenih serij zdravila.
PTH exerts its action via cell-surface parathyroid hormone receptors, present in bone, kidney and nerve tissue.
PTH deluje prek receptorjev za paratiroidni hormon na površini celic v kosteh, ledvicah in živčnem tkivu.
Less than or equal to 2.25 mmol/L and above 2 mmol/L
Enako ali manj kot 2,25 mmol/l in nad 2 mmol/l
The results demonstrate durability of the physiological effects of Natpar over 60 months including maintenance of mean albumin-corrected serum calcium levels (n=49, 2.11 ±0.19 mmol/L), a decrease from baseline in urinary calcium excretion (n=47, -2.23 ±5.9 mmol/24 h), a decrease in serum phosphate (n=49, -0.29 ±0.28 mmol/L) and the maintenance of normal calcium phosphate product (n=49, <4.4mmol
Ti učinki vključujejo vzdrževanje povprečnih serumskih koncentracij kalcija, korigiranih glede na albumin (n = 49, 2.11 ± 0.19mmol/l), zmanjšanje izločanja kalcija z urinom glede na izhodišče (n = 47, -2.23 ± 5.9 mmol/24 h), znižanje serumske ravni fosfata (n = 49, -0.29 ± 0.28 mmol/l) in vzdrževanje normalnega produkta kalcijevega fosfata (n = 49, < 4,4 mmol
Co-administration of alendronic acid and Natpar may lead to a reduction in the calcium sparing effect, which can interfere with the normalisation of serum calcium.
Sočasna uporaba alendronske kisline in zdravila Natpar zmanjša učinek varčevanja s kalcijem, ki lahko moti normalizacijo ravni kalcija v serumu.
Do not use the Natpar Pre-filled Pen unless you have been shown the right way to give the injections by a doctor or nurse.
Napolnjenega injekcijskega peresnika Natpar ne uporabljajte, če vam zdravnik ali medicinska sestra nista pokazala, kako si zdravilo pravilno injicirate.
How to use Natpar
Kako uporabljati zdravilo Natpar
At Week 24, for patients who completed the study, 34/79 (43%) Natpar patients were independent of active vitamin D treatment and were receiving no more than 500 mg of calcium citrate, compared with 2/33 (6.1%) placebo patients (p<0.001).
V 24. tednu je bilo med bolniki, ki so zaključili študijo, 34/79 (43 %) bolnikov, zdravljenih z zdravilom Natpar, neodvisnih od aktivnega vitamina D in je prejemalo največ 500 mg kalcijevega citrata v primerjavi z 2/33 (6,1 %) bolnikov, ki so prejemali placebo (p < 0,001).
If you have questions at any time, see the “Frequently Asked Questions” in Section E, contact your doctor or nurse, call Shire at +44 (0)800 055 6614, or email at medinfoEMEA@shire.com for help.
Če imate kadar koli vprašanja, glejte »Pogosta vprašanja« v poglavju E ali se za pomoč obrnite na zdravnika ali medicinsko sestro, pokličite družbo Shire na +44 (0)800 055 6614 ali pošljite e-sporočilo na medinfoEMEA@shire.com.
Cardiac disorders palpitations*
Srčne bolezni palpitacije*
What if I see more than 1 or 2 drops of medicine leak from my skin or from the needle tip during or after an injection?
Kaj naj naredim, če vidim, da iz kože ali konice igle med injiciranjem ali po njem izteče več kot le 1 ali 2 kapljici zdravila?
Natpar should be used with caution in patients with severe renal or hepatic disease because they have not been evaluated in clinical trials.
Pri bolnikih s hudo boleznijo ledvic ali jeter je treba zdravilo Natpar uporabljati previdno, ker jih še niso ocenjevali v kliničnih preskušanjih.
Your doctor will decide whether to start treatment with Natpar.
Zdravnik bo presodil, ali se smete začeti zdraviti z zdravilom Natpar.
If severe hypercalcaemia (>3.0 mmol/L or above upper limit of normal with symptoms) develops, hydration and temporarily stopping Natpar, calcium and active vitamin D should be considered until serum calcium returns to the normal range.
Če nastopi huda hiperkalciemija (> 3,0 mmol/l ali nad zgornjo mejo normalne vrednosti s simptomi), je treba razmisliti o hidraciji ter začasni ukinitvi zdravila Natpar, kalcija in aktivnega vitamina D, dokler se raven kalcija v serumu ne vrne na normalne vrednosti.
10 • While holding the pen with the needle cap pointing straight up, press the blue button on a flat surface until you hear or feel a ‘hard' click (See Figure K) and the blue button stays in.
10 • Medtem ko peresnik držite s pokrovčkom igle naravnost navzgor, pritisnite modri gumb na ravno površino, da zaslišite ali začutite »trd« klik (glejte sliko K) in ostane modri gumb pritisnjen.
Before throwing away your pen, be sure to remove the pen needle and dispose of it as instructed in Step 17: “Discard your used needles.” Then discard your used pen in the sharps container.
Preden peresnik zavržete, se prepričajte, da ste iglo peresnika odstranili in zavrgli v skladu z navodili v koraku 17: »Odstranjevanje uporabljenih igel.« Nato uporabljen peresnik odvrzite v vsebnik za ostre predmete.
Absorption Natpar administered subcutaneously had an absolute bioavailability of 53%.
Absorpcija Absolutna biološka uporabnost subkutano injiciranega zdravila Natpar je bila 53 %.
Do not use your pen on or after the “Discard On” date.
Peresnika ne uporabljajte po datumu »Zavrzite dne«.
Musculoskeletal and connective tissue disorders arthralgia*, muscle spasms muscle twitching musculoskeletal pain myalgia
Bolezni mišičnoskeletnega sistema in vezivnega tkiva artralgija*, spazem mišic trzanje mišic mišično-skeletna bolečina
Combined use of Natpar and cardiac glycosides (e.g., digoxin or digitoxin) may predispose patients to digitalis toxicity if hypercalcaemia develops.
Kombinirana uporaba zdravila Natpar in srčnih glikozidov (npr. digoksina ali digitoksina) lahko pri bolnikih povzroči dovzetnost za toksičnost digitalisa, če nastopi hiperkalciemija.
The most frequent adverse reactions among patients treated with Natpar were hypercalcaemia, hypocalcaemia, and their associated clinical manifestations including headache, diarrhoea, vomiting, paraesthesia, hypoaesthesia and hypercalciuria.
Najpogostejši neželeni učinki pri bolnikih, zdravljenih z zdravilom Natpar, so bili hiperkalciemija in hipokalciemija ter z njima povezani klinični pojavi, vključno z glavobolom, diarejo, bruhanjem, parestezijo, hipestezijo in hiperkalciurijo.
*Signs and symptoms potentially associated with hypercalcaemia that were observed in the clinical trials.
* Znaki in simptomi, ki bi bili lahko povezani s hiperkalciemijo, opaženi v kliničnih preskušanjih.
• Discard the used needle in a large, puncture-resistant sharps disposal container right away after use.
• Uporabljeno iglo takoj po uporabi zavrzite v velik vsebnik za odlaganje ostrih predmetov, odporen proti prebadanju.
This guide is designed to help you prepare, inject, and store your Natpar Pre-filled Pen.
Navodila za uporabo To navodilo je zasnovano za pomoč pri pripravi, injiciranju in shranjevanju napolnjenega injekcijskega peresnika Natpar.
If you are treated with Natpar, you may have side effects related to low or high levels of calcium in your blood (see section 4 for these side effects).
Če se zdravite z zdravilom Natpar, se lahko pojavijo neželeni učinki, povezani z nizkimi ali visokimi ravnmi kalcija v krvi (za te neželene učinke glejte poglavje 4).
The risk for serious hypocalcaemia is highest after Natpar is withheld, missed or abruptly discontinued, but can occur at any time.
Tveganje za resno hipokalciemijo je največje po odtegnitvi zdravljenja, izpuščenem odmerku ali nenadni prekinitvi zdravljenja z zdravilom Natpar, vendar se lahko pojavi kadar koli.
Greater than 2.25 mmol/L and below the upper limit of normal (2.55 mmol/L)*
Nad 2,25 mmol/l in pod zgornjo mejo normalne vrednosti (2,55 mmol/l)*
• After 5 minutes, if the liquid is colourless, go to the next step.
• Po 5 minutah pojdite na naslednji korak, če je tekočina brezbarvna.
After a single injection of parathyroid hormone (rDNA), the mean serum total calcium reached its peak level between 10 and 12 hours.
Po eni injekciji paratiroidnega hormona (rDNA) povprečna koncentracija skupnega kalcija v serumu doseže najvišjo vrednost v 10 do 12 urah.
If post-dose serum calcium remains >ULN, oral calcium supplementation should be further reduced or discontinued (see also adjustment table under Initiating Natpar).
Če koncentracija kalcija v serumu po odmerjanju ostane > ULN, je treba dodatno zmanjšati ali prekiniti peroralno dopolnjevanje kalcija (glejte tudi preglednico za prilagoditev odmerjanja v poglavju Začetek zdravljenja z zdravilom Natpar).
*These side effects may be related to high level of calcium in your blood.
* Ti neželeni učinki so lahko povezani z visokimi ravnmi kalcija v krvi.
The carton/pen label colour shows the strength of your Natpar medicine:
Barva škatle/oznake na injekcijskem peresniku označuje jakost zdravila Natpar:
Each dose must be administered as a subcutaneous injection once a day in alternating thighs.
Vsak odmerek je treba injicirati subkutano enkrat na dan, izmenično vsak dan v drugo stegno.
The goal of treatment with Natpar is to achieve calcaemic control and to reduce symptoms (see also section 4.4).
Cilj zdravljenja z zdravilom Natpar je doseči nadzor nad koncentracijo kalcija in s tem zmanjšanje simptomov (glejte tudi poglavje 4.4).
• Store in a refrigerator (2°C to 8°C).
• Shranjujte v hladilniku (od 2 °C do 8 °C).
Natpar pen 25 Natpar pen 50 Natpar pen 75 Natpar pen 100
Natpar peresnik 25 Natpar peresnik 50 Natpar peresnik 75 Natpar peresnik 100
Metacresol Water for injections
Vehikel metakrezol voda za injekcije
Common (may affect up to 1 in 10 people):
Pogosti (lahko se pojavijo pri manj kot 1 osebi od 10):
Hypercalcaemia may be minimised by following the recommended dosing, the monitoring information, and asking patients about any symptoms of hypercalcaemia.
Hiperkalciemija se lahko zmanjša z upoštevanjem priporočenega odmerjanja in podatkov, pridobljenih s spremljanjem bolnika, ter s poizvedovanjem pri bolniku glede morebitnih simptomov hiperkalciemije.
Do not dispose of your sharps disposal container in your household trash.
Vsebnika za odlaganje ostrih predmetov ne odvrzite med gospodinjske odpadke.
• citric acid monohydrate
• citronska kislina monohidrat
What should I do if the clear medicine cartridge is difficult to screw down?
Kaj naj naredim, če je prozorni vložek z zdravilom težko priviti?
• tingling and numbness of the skin
• mravljinčenje in otrplost kože
The pharmacokinetics of Natpar following subcutaneous administration in the thigh of hypoparathyroidism subjects was consistent with that observed in healthy post-menopausal women who received parathyroid hormone in the thigh and abdomen.
Farmakokinetika zdravila Natpar po subkutanem injiciranju v stegno pri preskušancih s hipoparatiroidizmom je bila skladna s farmakokinetiko, ki so jo opazili pri zdravih ženskah po menopavzi, ki so prejemale paratiroidni hormon v stegno in trebuh.
Natpar is a synthetic form of parathyroid hormone that helps you keep calcium and phosphate levels in your blood and urine at a normal level.
Zdravilo Natpar je sintetična oblika paratiroidnega hormona, ki pomaga vzdrževati normalne ravni kalcija in fosfata v krvi in urinu.
Psychiatric disorders anxiety †, insomnia*
Psihiatrične motnje tesnoba †, nespečnost*
Try again to slowly screw down the cartridge.
Vložek poskušajte počasi priviti navzdol.
Suggested adjustments to Natpar, active vitamin D and calcium supplements based on serum calcium levels are provided below:
Spodaj so na voljo predlagane prilagoditve zdravila Natpar, aktivnega vitamina D in kalcijevih dopolnil, ki temeljijo na koncentracijah kalcija v serumu:
In addition, 87% (73/84) of patients treated with Natpar showed a ≥50% reduction in oral active vitamin D versus 45% (18/40) in the placebo group.
Poleg tega je 87 % (73/84) bolnikov, zdravljenih z zdravilom Natpar, izkazalo zmanjšanje peroralnega aktivnega vitamina D za ≥ 50 % v primerjavi s 45 % (18/40) v skupini, ki je prejemala placebo.
In the clinical studies, these reactions were generally mild to moderate in severity and transient, and were managed with adjustments of Natpar, calcium and/or active vitamin D doses (see sections 4.4 and 5.1).
V kliničnih študijah so bili ti učinki večinoma blagi do zmerni in prehodni, obravnavali pa so jih s prilagoditvami odmerkov zdravila Natpar, kalcija in/ali aktivnega vitamina D (glejte poglavji 4.4 in 5.1).
A decision must be made whether to discontinue breast-feeding or to discontinue therapy with Natpar, taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Odločiti se je treba med prenehanjem dojenja in prekinitvijo zdravljenja z zdravilom Natpar, pri čemer je treba pretehtati koristi dojenja za otroka in koristi zdravljenja za mater.
In these studies, Natpar was self-administered, with daily doses ranging from 25 to 100 micrograms per subcutaneous injection.
V teh študijah so si bolniki sami odmerjali zdravilo Natpar v dnevnih odmerkih od 25 do 100 mikrogramov na subkutano injekcijo.
There is a ‘soft' click when you push the blue button before you hear the ‘hard' click, which indicates that you have begun to deliver the medicine.
Ko pritisnete modri gumb in preden boste zaslišali »trdi« klik, boste zaslišali »mehki« klik, kar pomeni, da se je dovajanje zdravila začelo.
Name and address of the manufacturer(s) responsible for batch release
Ime in naslov proizvajalca (proizvajalcev), odgovornega (odgovornih) za sproščanje serij
If pre-dose serum calcium is >2.25 mmol/L, a starting dose of 25 micrograms can be considered.
Če je raven kalcija v serumu pred odmerkom > 2,25 mmol/l, pride v poštev začetni odmerek 25 mikrogramov.
There were no apparent differences in the serum total calcium concentration-time profiles between the 2 hepatic function groups.
V profilih skupne serumske koncentracije kalcija v času ni bilo očitnih razlik med skupinama preskušancev z različnim delovanjem jeter.
The glass dual-chamber cartridge inside the pen is made from type I glass with 2 bromobutyl rubber stoppers and a crimp cap (aluminium) with a bromobutyl rubber seal.
Vložek z dvema komorama, ki je shranjen v peresniku, je izdelan iz stekla tipa I z 2 gumijastima zamaškoma iz bromobutilne gume in objemno zaporko (iz aluminija) s tesnilom iz bromobutilne gume.
Natpar is given as a subcutaneous (under the skin) injection every day, using a pen to help you inject your medicine.
Zdravilo Natpar se daje vsak dan v obliki subkutane (podkožne) injekcije s peresnikom, ki vam pomaga injicirati zdravilo.
Effect on mineral metabolism
Vpliv na presnovo mineralov
Prior to initiating and during treatment with Natpar:
Pred začetkom zdravljenja z zdravilom Natpar in med njim:
Hypercalcaemia commonly occurred during the titration period, during which doses of oral calcium, active vitamin D, and Natpar were being adjusted.
Hiperkalciemija je pogosto nastopila med obdobjem titriranja, ko so prilagajali odmerke peroralnega kalcija, aktivnega vitamina D in zdravila Natpar.
Consider reducing or stopping Natpar and re-assess by means of serum calcium measurement
Razmislite o zmanjšanju odmerka ali prekinitvi zdravljenja z zdravilom Natpar in znova ocenite z meritvijo kalcija v serumu.
The MAH should collect data on clinical hard endpoints (bone, soft tissue calcifications and renal function), together with data on hypercalciuria and quality of life.
Imetnik dovoljenja za promet z zdravilom mora zbrati podatke o osnovnih kliničnih opazovanih dogodkih (kosti, kalcifikacije mehkih tkiv in delovanje ledvic), skupaj s podatki o hiperkalciuriji in kakovosti življenja.
• Check that the yellow dose counter lines up with the black dot (See Figure E).
• Preverite, ali je rumeni števec odmerkov poravnan s črno piko (glejte sliko E).
The calcium-raising effect of Natpar may diminish over time in some patients.
Učinek zdravila Natpar na povečanje koncentracije kalcija se lahko pri nekaterih bolnikih sčasoma zmanjša.
• Write today's date in the space next to “Date Mixed”.
• v prostor poleg »Datum mešanja« vpišite današnji datum;
Natpar is contraindicated in patients: - with hypersensitivity to the active substance or to any of the excipients listed in section 6.1 - who are receiving or who have previously received radiation therapy to the skeleton - with skeletal malignancies or bone metastases - who are at increased baseline risk for osteosarcoma such as patients with Paget's disease of bone or hereditary disorders - with unexplained elevations of bone-specific alkaline phosphatase - with pseudohypoparathyroidism.
Zdravilo Natpar je kontraindicirano pri bolnikih: - ki so preobčutljivi na učinkovino ali katero koli pomožno snov, navedeno v poglavju 6.1; - ki se zdravijo ali so se v preteklosti zdravili z obsevanjem okostja; - z malignimi boleznimi kosti ali zasevki v kosteh; - ki imajo večje izhodiščno tveganje za osteosarkom, kot so bolniki s Pagetovo boleznijo kosti ali dednimi boleznimi; - z nepojasnjenimi zvišanimi ravnmi za kosti značilne alkalne fosfataze; - s psevdohipoparatiroidizmom.
6 • To mix the medicine, slowly screw down the cartridge in a clockwise direction (See “Before” figure) until you hear and feel a “click” and the cartridge will no longer turn (See “After” figure).
6 • Da zdravilo zmešate, počasi privijajte vložek navzdol v smeri urnega kazalca (glejte sliko »Prej«), dokler ne zaslišite klika in se vložek več ne obrača (glejte sliko »Potem«).
When you first start using Natpar, a trainer will guide you through how to mix your Natpar pen and give your injections.
Ko začnete prvič uporabljati peresnik Natpar, vas bo inštruktor vodil skozi postopek mešanja peresnika z zdravilom Natpar in postopek injiciranja.
Signs and symptoms potentially associated with hypocalcaemia that were observed in the clinical trials.
Znaki in simptomi, ki bi bili lahko povezani s hipokalciemijo, opaženi v kliničnih preskušanjih.
There are no data from the use of Natpar in pregnant women.
Podatkov o uporabi zdravila Natpar pri nosečnicah ni.
• increased level of calcium in your urine*
• zvišana raven kalcija v urinu*
A decision must be made whether to initiate or discontinue treatment with Natpar during pregnancy taking into account the known risks of therapy versus the benefit for the woman.
Pri sprejemanju odločitve o uvedbi ali ukinitvi zdravljenja z zdravilom Natpar med nosečnostjo je treba upoštevati znana tveganja pri zdravljenju v primerjavi s pričakovanimi koristmi za mater.
Peak plasma concentrations (mean Tmax) of Natpar occur within 5 to 30 minutes and a second usually smaller peak at 1 to 2 hours.
Najvišje plazemske koncentracije (povprečna vrednost Tmax) zdravila Natpar nastopijo v 5 do 30 minutah, z drugim, običajno manjšim vrhom po 1 do 2 urah.
This step primes your pen by removing the air from the cartridge.
S tem korakom iz vložka odstranite zrak in aktivirate svoj peresnik.
Natpar is suitable for patient self-administration.
Zdravilo Natpar je primerno za samoodmerjanje.
PHARMACEUTICAL FORM AND CONTENTS Powder and solvent for solution for injection 2 pre-filled pens
FARMACEVTSKA OBLIKA IN VSEBINA prašek in vehikel za raztopino za injiciranje 2 napolnjena injekcijska peresnika
Treatment with Natpar produces a decrease in urinary calcium excretion by 13 and 23% (50 and 100 microgram dose, respectively) to a nadir in the 3 to 6 hour time point, which returns to pre-dosing levels by 16 to 24 hours.
Zdravljenje z zdravilom Natpar povzroči zmanjšanje izločanja kalcija z urinom za 13 % pri odmerku 50 mikrogramov in 23 % pri odmerku 100 mikrogramov) z najnižjo točko po 3 do 6 urah in vrnitvijo na ravni pred odmerkom v 16 do 24 urah.
• Screw the needle straight onto the cartridge (See “Before” figure) until it is tightly attached (See “After” figure).
• Iglo privijte naravnost na vložek (glejte sliko »Prej«), dokler ni tesno pritrjena (glejte sliko »Potem«).
The aim of treatment with Natpar is to achieve a pre-dose serum calcium concentration of 2.0-2.25 mmol/L and an 8-12 hour post-dose serum calcium concentration <2.55 mmol/L.
Cilj zdravljenja z zdravilom Natpar je doseganje koncentracije kalcija v serumu pred odmerjanjem 2,0-2,25 mmol/l in koncentracije kalcija v serumu 8-12 ur po odmerjanju < 2,55 mmol/l.
In patients using calcium supplements, maintain calcium supplement dose.
Pri bolnikih, ki jemljejo kalcijeva dopolnila, ohranite odmerek teh dopolnil.
The response of serum calcium concentration to administration of Natpar should be monitored at intervals to detect this and the diagnosis of tachyphylaxis considered.
Občasno je treba spremljati odziv koncentracije kalcija na uporabo zdravila, da to zaznate in razmislite o diagnozi tahifilaksije.
Always store your pen in the refrigerator between 2°C to 8°C.
Peresnik vedno shranjujte v hladilniku pri temperaturi od 2 °C do 8 °C.
In patients using Natpar concomitantly with cardiac glycosides (such as digoxin or digitoxin), monitor serum calcium and cardiac glycoside levels and patients for signs and symptoms of digitalis toxicity (see section 4.5).
Pri bolnikih, ki uporabljajo zdravilo Natpar sočasno s srčnimi glikozidi (npr. digoksinom ali digitoksinom), je treba spremljati ravni kalcija in srčnih glikozidov v serumu ter znake in simptome toksičnosti digitalisa (glejte poglavje 4.5).
EXP Discard mixed pen after 14 days.
EXP Peresnik z zmešanim zdravilom zavrzite po 14 dneh.
Metabolism and nutrition disorders hypercalcaemia, hypocalcaemia hypomagnesaemia tetany
Presnovne in prehranske motnje hiperkalciemija, hipokalciemija hipomagneziemija tetanija
The mean maximum concentration (Cmax) of PTH following 100 micrograms parathyroid hormone (rDNA) in subjects with mild-to-moderate renal impairment (CLcr 30 to 80 mL/min) was approximately 23% higher than that observed in subjects with normal renal function.
Povprečna najvišja koncentracija (Cmax) PTH po 100 mikrogramih paratiroidnega hormona (rDNA) pri osebah z blago do zmerno okvaro ledvic (CLcr od 30 do 80 ml/min) je bila za približno 23 % višja kot pri preskušancih z normalnim delovanjem ledvic.
The maximum mean increases of serum calcium, which occurred at 12 hours, were approximately 0.125 mmol/L and 0.175 mmol/L with the 50 micrograms and 100 micrograms dose, respectively.
Najvišja povprečna zvišanja ravni kalcija v serumu, ki so nastopila po 12 urah, so bila pri odmerku 50 mikrogramov približno 0,125 mmol/l, pri odmerku 100 mikrogramov pa 0,175 mmol/l.
These side effects may be related to low level of calcium in your blood.
Ti neželeni učinki so lahko povezani z nizkimi ravnmi kalcija v krvi.
A minimal amount of Natpar is excreted in the milk of lactating rats.
V mleko podgan v laktaciji se izloča zelo majhna količina zdravila Natpar.
Figure L The setup of your pen is complete.
Slika L Priprava peresnika je končana.
In the placebo-controlled study, 9.5% (8/84) Natpar-treated patients and 15% (6/40) placebo-treated patients experienced an injection site reaction, all of which were mild or moderate in severity.
V študiji, nadzorovani s placebom, je 9,5 % (8/84) bolnikov, zdravljenih z zdravilom Natpar, in 15 % (6/40) bolnikov, ki so prejemali placebo, doživelo reakcijo na mestu injiciranja.
Calcium supplement
Kalcijevo dopolnilo
If needed, clean the pen by wiping the outside with a cloth dampened with water.
Peresnik po potrebi očistite tako, da zunanjost obrišete s krpo, navlaženo z vodo.
Natpar is a hormone replacement for adults with under-active parathyroid glands, a condition known as ‘hypoparathyroidism'.
Zdravilo Natpar je hormonski nadomestek za zdravljenje odraslih s premalo delujočimi obščitničnimi (paratiroidnimi) žlezami, tj. boleznijo, znano kot hipoparatiroidizem.
Clinical studies with Natpar did not include sufficient numbers of subjects aged 65 and over to determine whether response in these subjects is different from younger subjects.
Klinične študije z zdravilom Natpar niso vključevale zadostnega števila preskušancev, starih 65 let in več, da bi ugotovili, ali se odzivajo drugače kot mlajši.
Store in a refrigerator (2°C - 8°C).
Shranjujte v hladilniku (2 °C-8 °C).