natgillin/translations-raw huggingface dataset:
All regulations concerning handling of pressure vessels must be followed.
Upoštevati morate vse predpise o ravnanju s tlačnimi posodami.
Prior to launch of the new indication of the product in each Member State, the Marketing Authorisation Holder shall agree the content and format of the educational material with the national competent authority.
Dodatni ukrepi za zmanjševanje tveganj Imetnik dovoljenja za promet z zdravilom naj pred uvedbo nove indikacije za zdravilo v vsaki državi članici s pristojnim nacionalnim organom dogovori vsebino in obliko izobraževalnega gradiva.
Nitrate is cleared from the plasma by the kidney at rates approaching the rate of glomerular filtration.
Ledvice očistijo nitrat iz plazme pri hitrosti, podobni hitrosti glomerulne filtracije.
OTHER SPECIAL WARNING(S), IF NECESSARY Ensure that the parent or guardian has read and is aware of the indications and cautions presented in the package leaflet prior to administration to their baby.
DRUGA POSEBNA OPOZORILA, ČE SO POTREBNA Zagotovite, da pred uporabo zdravila pri otroku roditelj ali skrbnik prebere navodilo za uporabo in je seznanjen z indikacijami in opozorili v navodilu.
Acute toxicity is related to anoxia resulting from elevated methaemoglobin levels.
Akutna toksičnost je povezana z anoksijo, kar povzroča povišane ravni methemoglobina.
Nitric oxide is delivered to the patient via mechanical ventilation after dilution with an oxygen/air mixture using an approved (CE-marked) nitric oxide delivery system.
Dušikov oksid dovajamo bolnikom z mehanskim predihavanjem po razredčenju z mešanico kisika/zraka z uporabo odobrenega (z oznako CE) sistema za dovajanje dušikovega oksida.
LIST OF EXCIPIENTS Also contains nitrogen.
SEZNAM POMOŽNIH SNOVI Vsebuje tudi dušik.
Abrupt discontinuation of the administration of inhaled nitric oxide may cause rebound reaction; decrease in oxygenation and increase in central pressure and subsequent decrease in systemic blood pressure.
Nenadna prekinitev zdravljenja z vdihovanjem dušikovega oksida lahko povzroči povratno reakcijo, zmanjšanje oksigenacije, povečanje centralnega tlaka in posledično zmanjšanje sistemskega krvnega tlaka.
BRAILLE Justification for not including Braille accepted
PODATKI V BRAILLOVI PISAVI Sprejeta je utemeljitev, da Braillova pisava ni potrebna.
Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia, sepsis, hyaline membrane disease, congenital diaphragmatic hernia (CDH), and pulmonary hypoplasia.
se pojavlja kot primarna razvojna okvara ali kot posledica drugih bolezni, kot so mekonijski aspiracijski sindrom (MAS), pljučnica, sepsa, sindrom dihalne stiske pri novorojenčkih, prirojena diafragmalna hernija (CDH - »congenital diaphragmatic hernia«) in pljučna hipoplazija.
Description of selected adverse reactions Inhaled nitric oxide therapy may cause an increase in methaemoglobin.
Opis izbranih neželenih učinkov Zdravljenje z vdihavanjem dušikovega oksida lahko povzroči povišanje ravni methemoglobina.
Inside this place, a separate premise should be dedicated to the storage of nitric oxide gas cylinders.
Znotraj tega prostora morate dodeliti ločene prostore, namenjene le shranjevanju jeklenk z dušikovim oksidom.
Effects on platelets
Učinek na krvne ploščice
It relaxes vascular smooth muscle by binding to the haeme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation.
Pri tem aktivira gvanilat-ciklazo in poveča znotrajcelične koncentracije cikličnega gvanozin-3',5'-monofosfata, kar pripelje do vazodilatacije.
This gas mixture can improve heart function and increase the flow of blood through the lungs, which may help to increase the amount of oxygen that reaches the blood.
Ta mešanica plinov lahko izboljša delovanje srca in poveča pretok krvi v pljučih, kar lahko pripomore k povečanju količine kisika,
d
V
4.4 Special warnings and precautions for use
4.4 Posebna opozorila in previdnostni ukrepi Nezadosten odziv
Consideration should be given to discontinuation of treatment if no beneficial physiological effects are apparent after a 30-minute trial of therapy.
Če se po 30 minutah poskusnega zdravljenja ne pojavijo nobeni koristni fiziološki učinki, je treba razmisliti o prekinitvi zdravljenja.
Limay Porcheville 3 avenue Ozanne 78440 Porcheville France
Limay-Porcheville 3 avenue Ozanne 78440 Porcheville Francija
These include prilocaine (a local anaesthetic used for pain relief in association to minor painful procedures e.g. suturing, and minor surgical or diagnostic procedures) or glyceryl trinitrate (used to treat chest pain).
(lokalnim anestetikom, ki se uporablja za lajšanje bolečine pri manjših bolečih posegih, kot je šivanje, in manjših kirurških ali diagnostičnih postopkih) ali gliceriltrinitratom (za zdravljenje bolečin v prsih).
INOmax should be used and administered only by personnel specially trained in the use and handling of INOmax.
• Zdravilo INOmax sme uporabljati in dajati bolnikom samo osebje, ki je posebej usposobljeno za uporabo tega zdravila in ravnanje z njim.
Tested polymers which can be used in nitric oxide administration systems include polyethylene (PE) and polypropylene (PP).
Med preizkušene polimere, ki jih lahko uporabimo pri sistemih za dovajanje dušikovega oksida, spadata polietilen (PE)
INOmax cylinders should be stored secured in order to avoid falling and thus potentially causing harm.
• Jeklenke INOmax je treba shranjevati varno, tako da ne morejo pasti in povzročiti škode.
Prescription should be limited to those neonatal units that have received adequate training in the use of a nitric oxide delivery system.
Predpisovanje naj bo omejeno na tiste enote za novorojenčke, ki so ustrezno usposobljene za uporabo sistema za dovajanje dušikovega oksida.
In the presence of oxygen, nitric oxide is rapidly oxidised to derivatives which are toxic to the bronchial epithelium and alveolo-capillary membrane.
V prisotnosti kisika dušikov oksid hitro oksidira v snovi, ki so toksične za epitel bronhijev in alveolokapilarne membrane.
In one clinical study (NINOS), treatment groups were similar with respect to the incidence and severity of intracranial haemorrhage, Grade IV haemorrhage, periventricular leukomalacia, cerebral infarction, seizures requiring anticonvulsant therapy, pulmonary haemorrhage, or gastrointestinal haemorrhage.
V eni od kliničnih študij (NINOS) je bila pri skupinah bolnikov, ki so prejemali zdravilo, podobna incidenca in intenzivnost intrakranialnih krvavitev, krvavitev 4. stopnje, periventrikularne levkomalacije, možganske kapi, epileptičnih napadov, ki so zahtevali zdravljenje s protikonvulzivnimi zdravili, pljučnih krvavitev in krvavitev v prebavilih.
Data in adult humans are conflicting, and there has been no increase in bleeding complications in randomised controlled trials in term and near-term neonates with hypoxic respiratory failure.
Podatki pri odraslih ljudeh so si nasprotujoči, pri randomiziranih nadzorovanih kliničnih preizkušanjih na novorojenčkih s hipoksično respiratorno odpovedjo, rojenih v roku ali blizu roka, pa ni bilo povečanja zapletov pri krvavitvah.
Side effects that are commonly seen (affects more than 1 user in 100) in association with INOmax therapy include:
Neželeni učinki, ki se pogosto (pri več kot 1 od 100 bolnikov) pojavijo pri zdravljenju z zdravilom INOmax, so:
The gas cylinder should be put in an equipped site with appropriate material in order to hold the cylinder vertically.
Jeklenko morate namestiti v prostor, opremljen z ustreznimi materiali, ki omogočajo, da je jeklenka postavljena pokončno.
Bradycardia (low cardiac frequency) or too low amount of oxygen in the blood (oxygen desaturation/hypoxemia) due to sudden withdrawal of the treatment, Headache, dizziness, dry throat or shortness of breath following accidental ambient air exposure to nitric oxide (e.g. leakage from equipment or cylinder).
• bradikardija (zmanjšan srčni utrip) ali nezadostna količina kisika v krvi (desaturacija kisika/hipoksemija), ki nastane ob nenadni prekinitvi zdravljenja; • glavobol, omotica, suho grlo ali zasoplost po nenamerni izpostavljenosti dušikovemu oksidu v zraku okolja (npr. pri puščanju opreme ali jeklenke).
The starting dose of inhaled nitric oxide is 20 ppm (part per million) of inhaled gas.
Začetni odmerek inhalacijskega dušikovega oksida je 20 ppm (delcev na milijon) vdihanega plina.
The table below presents adverse reactions (ADRs) that have been reported with the use of INOmax from either the CINRGI trial of 212 neonates or post marketing experience in neonates (<1 months of age)).
V spodnji preglednici so neželeni učinki, o katerih so poročali pri uporabi zdravila INOmax v preskušanju CINRGI pri 212 novorojenčkih ali v obdobju trženja pri novorojenčkih (starih <1 mesec).
Prescription should be limited to those cardio-thoracic units that have received adequate training in the use of a nitric oxide delivery system.
Predpisovanje mora biti omejeno na kardiotorakalne enote, ki so ustrezno usposobljene za uporabo sistemov za dovajanje dušikovega oksida.
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Linde Healthcare AB
IME IN NASLOV IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM Linde Healthcare AB
The monitoring of Methaemoglobin level
• Spremljanje ravni methemoglobina.
See section 4.2 for information on monitoring for NO2.
Informacije o nadzorovanju koncentracije NO2 boste našli v poglavju 4.2.
When inhaled, nitric oxide produces selective pulmonary vasodilation.
Dušikov oksid pri vdihavanju povzroča selektivno pljučno vazodilatacijo.
Pharmacotherapeutic group: Other respiratory system products, ATC code R07AX01.
Oznaka ATC: R07AX01.
In biological tissue, nitric oxide may form peroxynitrite with superoxide (O2-), an unstable compound which may cause tissue damage through further redox reactions.
Dušikov oksid v tkivih lahko s superoksidom (O2-) tvori peroksinitrit, nestabilno spojino, ki lahko z nadaljnjimi reakcijami oksidacije in redukcije povzroči poškodbe tkiv.
The physician should have access at the bedside to a reserve nitric oxide delivery system.
Zdravniki morajo ob bolniških posteljah imeti dostop do nadomestnega sistema za dovajanje dušikovega oksida.
Nitric oxide chemically reacts with oxygen to form nitrogen dioxide.
Dušikov oksid kemično reagira s kisikom in tvori dušikov dioksid.
Too rapid weaning from inhaled nitric oxide therapy carries the risk of a re-bound increase in pulmonary artery pressure with subsequent circulatory instability.
Prehitra prekinitev zdravljenja z inhalacijskim dušikovim oksidom pomeni tveganje za povratno povišanje tlaka v pljučni arteriji, kar posledično povzroči nestabilnost krvnega obtoka.
Store gas cylinders indoors in well-ventilated rooms or outdoors in ventilated sheds where they are protected from rain and direct sunlight.
Jeklenke shranjujte v zaprtih, dobro prezračenih prostorih ali na prostem, v prezračenih lopah, kjer bodo zaščitene pred dežjem in neposredno sončno svetlobo.
Animal models have shown that nitric oxide may interact with haemostasis, resulting in an increased bleeding time.
Poskusi na živalih so pokazali, da dušikov oksid lahko vpliva na hemostazo in podaljša krvavitve.
Your or your child's doctor will undertake monitoring of nitrogen dioxide and in case of elevated values the INOmax therapy will be adjusted, decreased accordingly.
Zdravnik, ki zdravi vas ali vašega otroka, bo spremljal ravni dušikovega dioksida in, če bodo te previsoke, ustrezno zmanjšal odmerek zdravila INOmax.
When inhaled, this gas mixture can improve the flow of blood through the lungs, which may help to increase the amount of oxygen that reaches your baby's blood.
Vdihavanje te mešanice plinov lahko izboljša pretok krvi skozi pljuča, kar pripomore k povečanju količine kisika, ki pride v dojenčkovo kri;
The potential risk of bleeding and haemostasis disorders The potential risks if used in combination with other vasodilators which act on cGMP or cAMP
• Možno tveganja, če se zdravilo uporablja v kombinaciji z drugimi vazodilatatorji, ki delujejo na cGMP ali cAMP.
What you need to know before you begin a treatment with INOmax
Kaj morate vedeti, preden boste uporabili zdravilo INOmax Ne uporabljajte zdravila INOmax:
The adverse events collected occurred at similar incidence rates in both groups.
Pogostnost neželenih učinkov je bila v obeh skupinah podobna.
A clinically significant interaction with other medicinal products used in the treatment of hypoxic respiratory failure cannot be excluded based on the available data.
Na osnovi razpoložljivih podatkov ne moremo izključiti klinično značilnih interakcij z drugimi zdravili, ki jih uporabljamo pri zdravljenju hipoksične respiratorne odpovedi.
The dose should be incrementally reduced to 1 ppm for 30 minutes with close observation of systemic and central pressure, and then turned off. Weaning should be attempted at least every 12 hours when the patient is stable on a low dose of INOmax.
Odmerek je treba postopoma zmanjšati na 1 ppm v 30 minutah, pri čemer je treba skrbno spremljati sistemski in centralni tlak, potem pa sistem izklopiti.
The educational material should include information on the following key elements: The risk of rebound effect and the precautions to take when discontinuing the treatment The risk of abrupt discontinuation of INOmax therapy in the event of critical failure of the delivery system and how to prevent it
Izobraževalno gradivo naj vključuje informacije o naslednjih ključnih elementih: • Tveganje povratnega učinka in previdnostni ukrepi, ki jih je treba upoštevati pri prekinitvi zdravljenja.
If it is > 2.5 %, the INOmax dose should be decreased and the administration of reducing medicinal products such as methylene blue may be considered.
Če je koncentracija methemoglobina >2,5 %, zmanjšajte odmerek zdravila INOmax, poleg tega pa razmislite o uporabi reducentov, kot je metilen modro.
Blood and lymphatic system disorders
Bolezni krvi in limfatičnega citopenijaa methemoglobinemijaa sistema
Monitoring formation of methaemoglobin (MetHb) Neonates and infants are known to have diminished MetHb reductase activity compared to adults.
Znano je, da je aktivnost methemoglobin-reduktaze pri novorojenčkih in dojenčkih manjša kot pri odraslih.
During inter- or within-hospital transfers of patients treated with INOmax, the gas cylinders should be fixedly stowed away in order to hold the gas cylinders vertically and to avoid the risk of fall or untimely modifying output.
Med premeščanjem bolnikov, ki prejemajo zdravilo INOmax, znotraj bolnišnice ali med bolnišnicami morajo biti jeklenke trdno nameščene v pokončen položaj, da bi preprečili padce ali neprimerno spremembo dovajanja.
A large portion of nitric oxide for inhalation is absorbed systemically.
Nastajanje methemoglobina Velik delež vdihnjenega dušikovega oksida se absorbira sistemsko.
(see section 6 ‘further information' where the full list of ingredients is provided).
Dodatne informacije, ki vsebuje seznam vseh sestavin.
The rebound may be seen early as well as late during therapy.
Povratna reakcija lahko nastopi na začetku zdravljenja ali kasneje med zdravljenjem.
INOmax should only be delivered according to an anaesthetist's or intensive care physician's prescription.
Zdravilo INOmax se lahko dovaja samo, če ga predpiše anestezist ali zdravnik z intenzivne nege.
INOmax should not be used in preterm baby < 34 weeks of gestational age.
Zdravilo INOmax se ne sme uporabljati pri nedonošenčkih, mlajših od 34 tednov nosečnosti.
The mean methaemoglobin levels remained below 1 % in the placebo group and in the 5 ppm and 20 ppm INOmax groups, but reached approximately 5 % in the 80 ppm INOmax group.
V skupini s placebom ter v skupinah, ki so prejemale 5 ppm in 20 ppm zdravila INOmax, so se povprečne koncentracije methemoglobina obdržale pod 1 % .
Some medicines can affect the ability of blood to carry oxygen.
Nekatera zdravila lahko vplivajo na sposobnost krvi za prenašanje kisika, vključno s prilokainom
In the INOT27 trial, 795 preterm infants (GA<29 weeks) with hypoxic respiratory failure were randomised to receive either INOmax (n=395) in a dose of 5 ppm or nitrogen (placebo n=400),
V preskušanju INOT27 so 795 nedonošenčkov (gestacijska starost < 29 tednov) s hipoksično odpovedjo dihal naključno razporedili v skupini, ki sta prejemali zdravilo INOmax (n = 395) v odmerku 5 ppm oziroma dušik (placebo n = 400) v prvih 24 urah življenja in ki so se zdravili od 7 do
What INOmax looks like and contents of the pack Inhalation gas
Izgled zdravila INOmax in vsebina pakiranja plin za inhaliranje
METHOD AND ROUTE(S) OF ADMINISTRATION Endotracheopulmonary use.
POSTOPEK IN POT(I) UPORABE ZDRAVILA Endotraheopulmonalna uporaba.
A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE C. OTHER CONDITIONS AND REQUIREMENTS OF THE MARKETING
B. POGOJI ALI OMEJITVE GLEDE OSKRBE IN UPORABE C. DRUGI POGOJI IN ZAHTEVE DOVOLJENJA ZA PROMET Z ZDRAVILOM
For patients transported to other facilities for additional treatment, who need to continue with inhaled nitric oxide, arrangements should be made to ensure the continuous supply of inhaled nitric oxide during transportation.
Pri bolnikih, ki bodo zaradi dodatnega zdravljenja premeščeni v druge ustanove in ki morajo še naprej vdihovati dušikov oksid, poskrbite, da bodo med prevozom imeli neprekinjeno dovajanje dušikovega oksida.
In the pivotal clinical trials, the starting dose was 20 ppm.
V ključnih kliničnih preizkušanjih so uporabili začetni odmerek 20 ppm.
Store gas cylinders vertically in well-ventilated rooms.
Jeklenke shranjujte pokončno v dobro prezračenih prostorih.
The withdrawal of inhaled nitric oxide therapy should be performed in a stepwise manner.
Prekinitev zdravljenja z inhalacijskim dušikovim oksidom je treba opraviti po korakih.
In the CINRGI trial, 186 term- and near-term neonates with hypoxic respiratory failure and without lung hypoplasia were randomised to receive either INOmax (n=97) or nitrogen gas (placebo; n=89) with an initial dose of 20 ppm weaning to 5 ppm in 4 to 24 hours with median duration of exposure of 44 hours.
V preskušanju CINRGI so naključno razdelili 186 novorojenčkov s hipoksično respiratorno odpovedjo in brez pljučne hipoplazije, rojenih v roku ali blizu roka, tako da so prejemali bodisi zdravilo INOmax (n = 97) ali dušik v plinasti obliki (placebo; n = 89) v začetnem odmerku 20 ppm, ki so ga zmanjševali do 5 ppm v 4 do 24 urah z mediano trajanja izpostavitve 44 ur.
During treatment with nitric oxide, the NO2 concentration should be < 0.5 ppm in the nitric oxide dose range < 20 ppm.
Med zdravljenjem z dušikovim oksidom v odmerku do 20 ppm mora biti koncentracija NO2 <0,5 ppm.
At low oxygen saturation, nitric oxide can combine with deoxyhaemoglobin to transiently form nitrosylhaemoglobin, which is converted to nitrogen oxides and methaemoglobin upon exposure to oxygen.
Pri nizki nasičenosti s kisikom se dušikov oksid lahko veže z deoksihemoglobinom in prehodno tvori nitrozilhemoglobin, ki se po izpostavitvi kisiku pretvori v dušikove okside in methemoglobin.
Studies show that nitric oxide exhibits pulmonary pharmacodynamic effects at intra-airway concentrations as low as 1 ppm.
Študije so pokazale, da ima dušikov oksid farmakodinamične učinke na pljuča že pri tako nizkih koncentracijah v dihalih,
Nitric oxide has an unpaired electron, which makes the molecule reactive.
Molekula dušikovega oksida ima en neparni elektron in je zato zelo reaktivna.
Nitrogen dioxide (NO2) is the main substance formed, and may cause airway inflammation and damage.
Večinoma nastaja dušikov dioksid (NO2), ki lahko povzroči vnetje in poškodbe dihalnih poti.
No difference in the incidence of IVH or death was however observed in this study.
V tej študiji niso opazili razlike v incidenci intraventrikularne krvavitve ali smrti.
Regular monitoring of haemostasis and measurement of bleeding time is recommended during the administration of INOmax for more than 24 hours to patients with functional or quantitative platelet anomalies, a low coagulation factor or receiving anticoagulation treatment.
Kadar se zdravilo INOmax več kot 24 ur daje bolnikom s funkcionalnimi ali kvantitavnimi anomalijami krvnih ploščic, nizkim koagulacijskim faktorjem ali bolnikom, ki se zdravijo z antikoagulanti, se priporoča redno spremljanje hemostaze in merjenje časa krvavitve.
INOmax, in conjunction with ventilatory support and other appropriate active substances, is indicated: for the treatment of newborn infants ≥ 34 weeks gestation with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, in order to improve oxygenation and to reduce the need for extracorporeal membrane oxygenation.
• zdravljenju novorojenčkov, rojenih po vsaj 34 tednih nosečnosti, s hipoksično respiratorno odpovedjo, povezano s kliničnim ali ehokardiogramskim dokazom pljučne hipertenzije, z namenom izboljšanja oksigenacije in zmanjšanja potrebe po zunajtelesni membranski oksigenaciji;
The INOmax dose should not be discontinued abruptly as it may result in an increase in pulmonary artery pressure (PAP) and/or worsening of blood oxygenation (PaO2).
(PAP - »pulmonary artery pressure«) in/ali poslabšala oksigenacija krvi (PaO2).
INOmax contains Nitrogen
Zdravilo INOmax vsebuje dušik.
You should directly inform the personnel if you experience headache while being in close proximity to your child receiving INOmax.
Če dobite glavobol, medtem ko ste v bližini svojega otroka, ki prejema zdravilo INOmax, morate o tem obvestiti osebje.
Pulmonary hypertension associated with heart surgery Prescription of nitric oxide should be supervised by a physician experienced in cardiothoracic anaesthesia & intensive care.
Predpisovanje dušikovega oksida mora nadzorovati zdravnik z izkušnjami s kardiotorakalno anestezijo in intenzivno nego.
Contents of the pack and other information
Shranjevanje zdravila INOmax Vsebina pakiranja in dodatne informacije
Inhaled nitric oxide may influence the oxygen carrying capacity of the blood.
Vdihavanje dušikovega oksida lahko vpliva na sposobnost krvi za prenašanje kisika.
- Setting the NO, NO2 and O2 monitors for high and low alarm limits - Using the manual backup delivery system - Procedures for correctly switching gas cylinders and purging system - Troubleshooting alarms - NO, NO2 and O2 monitor calibration - Monthly system performance check-up procedures
- Nastavitev naprave za dovajanje pravilne koncentracije dušikovega oksida - Nastavljanje nadzornih naprav za alarmne signale pri visokih in nizkih koncentracijah NO, NO2
Polytrifluorochloroethylene, hexafluoropropene-vinyliden copolymer and polytetraflourethylene have been used extensively with pure nitric oxide and other corrosive gases.
S čistim dušikovim oksidom in drugimi jedkimi plini so pogosto uporabljali politrifluorokloroetilen, heksafluoropropenviniliden kopolimer in politetrafluoretilen.
Methaemoglobin disposition has been investigated as a function of time and nitric oxide exposure concentration in neonates with respiratory failure.
Stanje methemoglobina pri novorojenčkih z respiratorno odpovedjo so raziskovali kot funkcijo časa in izpostavljenosti koncentracijam dušikovega oksida.
The end medicinal products of nitric oxide that enter the systemic circulation are predominantly methaemoglobin and nitrate.
Končna produkta dušikovega oksida, ki vstopita v krvni obtok, sta večinoma methemoglobin in nitrat.
There is an increased risk of methaemoglobin formation if substances with a known tendency to increase methaemoglobin concentrations are administered concomitantly with nitric oxide (e.g. alkyl nitrates and sulphonamides).
Pri sočasni uporabi dušikovega oksida in snovi, za katere je znano, da povečajo koncentracije methemoglobina (npr. alkilni nitrati in sulfonamidi), obstaja povečano tveganje za tvorbo methemoglobina.
The monitoring of NO2 formation
• Spremljanje nastajanja NO2.
Transport of gas cylinders
Prevoz jeklenk