natgillin/translations-raw huggingface dataset:
Lipodystrophy may occur at the injection site and delay local insulin absorption.
Na injekcijskem mestu se lahko pojavi lipodistrofija in upočasni lokalno absorpcijo insulina.
Solution for injection (injection) in pre-filled pen (KwikPen) Clear, colourless solution.
raztopina za injiciranje (injekcija) v napolnjenem injekcijskem peresniku (KwikPen) Bistra, brezbarvna raztopina.
For more information, see the box at the end of this leaflet.
Za več informacij glejte okvir na koncu tega navodila za uporabo.
- The other ingredients are: zinc oxide, metacresol, glycerol, sodium hydroxide (see section 2 “Important information about some of the ingredients of ABASAGLAR”), hydrochloric acid and water for injections.
- Druge sestavine zdravila so: cinkov oksid, metakrezol, glicerol, natrijev hidroksid (glejte poglavje 2 "Pomembne informacije o nekaterih sestavinah zdravila ABASAGLAR"), klorovodikova kislina in voda za injekcije.
ABASAGLAR KwikPen is a pre-filled disposable pen containing insulin glargine.
ABASAGLAR KwikPen je napolnjen peresnik za enkratno uporabo, ki vsebuje insulin glargin.
ABASAGLAR should not be administered intravenously.
Zdravila ABASAGLAR se ne sme dajati intravensko.
A marked change in glycaemic control may cause temporary visual impairment, due to temporary alteration in the turgidity and refractive index of the lens.
Izrazita sprememba glikemične urejenosti lahko prehodno poslabša vid zaradi prehodno spremenjenega turgorja in lomnega količnika leče.
Rare side effects (may affect up to 1 in 1,000 people)
Redko poročani neželeni učinki (pojavijo se lahko pri največ 1 od 1.000 bolnikov)
Do not stop ABASAGLAR without speaking to a doctor, who will tell you what needs to be done.
ABASAGLAR, ne da bi se pogovorili z zdravnikom.
Tap the cartridge holder gently to collect air bubbles at the top.
Nežno potrepljajte držalo vložka, tako da se bodo zračni mehurčki nabrali na vrhu.
No new safety signals were seen during this extended treatment with insulin glargine.
Med tem podaljšanim zdravljenjem z insulinom glargin niso odkrili nobenih novih varnostnih signalov.
• ABASAGLAR KwikPen
• Peresnik ABASAGLAR KwikPen
ABASAGLAR is administered subcutaneously.
Zdravilo ABASAGLAR se daje subkutano.
ABASAGLAR contains insulin glargine, an insulin analogue and has a prolonged duration of action.
Zdravilo ABASAGLAR vsebuje insulin glargin, insulinski analog s podaljšanim delovanjem.
The pen should be used as recommended in the information provided with the device.
Peresnik morate uporabljati, kot je priporočeno v informacijah, priloženih pripomočku.
Lipohypertrophy
Lipohipertrofija
Insulin glargine has a long and steady blood-sugar-lowering action.
Insulin glargin znižuje krvni sladkor dolgo in enakomerno.
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity to reproduction.
Predklinični podatki na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih se odmerkih, genotoksičnosti, kancerogenega potenciala in vpliva na sposobnost razmnoževanja ne kažejo posebnega tveganja za človeka.
Refer to the instructions for using the pen.
Glejte navodila za uporabo peresnika.
To reduce the risk of hypoglycemia, patients who are changing their basal insulin regimen from an insulin regimen with once daily insulin glargine 300 units/ml to a once daily regimen with ABASAGLAR should reduce their dose by approximately 20%.
Bolniki, ki spremenijo svoj režim z bazalnim insulinom tako, da z insulina glargina 300 enot/ml enkrat na dan preidejo na zdravilo ABASAGLAR enkrat na dan, morajo za zmanjšanje nevarnosti hipoglikemije svoj odmerek insulina zmanjšati za približno 20%.
Do not refrigerate or freeze.
Ne shranjujte v hladilniku in ne zamrzujte.
Effects of insulin glargine (once daily) on diabetic retinopathy were evaluated in an open-label 5 year NPH-controlled study (NPH given bid) in 1024 type 2 diabetic patients in which progression of retinopathy by 3 or more steps on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale was investigated by fundus photography.
kontrolirani študiji (NPH apliciran dvakrat na dan) pri 1.024 bolnikih z diabetesom tipa 2, pri katerih so napredek retinopatije za tri ali več stopenj po lestvici ETDRS (Early Treatment Diabetic Retinopathy Study) preiskovali s slikanjem očesnega ozadja.
Beta-blockers like other sympatholytic medicines (such as clonidine, guanethidine, and reserpine) may weaken or suppress entirely the first warning symptoms which help you to recognise a hypoglycaemia.
Zaviralci adrenergičnih receptorjev beta lahko, tako kot druga simpatikolitična zdravila (kot so klonidin, gvanetidin in reserpin), oslabijo ali popolnoma preprečijo prve opozorilne simptome, ki vam pomagajo prepoznati hipoglikemijo.
- inject the amount left in your pen and then use a new pen to give the rest of your dose, or
- injicirate preostalo količino insulina iz peresnika, nato pa za dajanje preostanka svojega odmerka uporabite nov peresnik, ali pa - vzamete nov peresnik in si injicirate celoten odmerek.
• Do not freeze ABASAGLAR.
• Ne zamrzujte zdravila ABASAGLAR.
Examples include: - you inject too much insulin, - you miss meals or delay them, - you do not eat enough, or eat food containing less carbohydrate than normal (sugar and substances similar to sugar are called carbohydrates; however, artificial sweeteners are NOT
- izpustite obroke ali jih imate prepozno, - ne jeste dovolj ali uživate hrano, ki vsebuje manj ogljikovih hidratov kot normalno (sladkor in sladkorju podobne snovi imenujemo ogljikovi hidrati; toda umetna sladila NISO ogljikovi hidrati), - izgubljate ogljikove hidrate zaradi bruhanja ali driske,
Patients with high insulin doses because of antibodies to human insulin may experience an improved insulin response with ABASAGLAR.
Pri bolnikih, ki zaradi protiteles proti humanemu insulinu potrebujejo velike odmerke insulina, se lahko pri jemanju zdravila ABASAGLAR odziv na insulin izboljša.
Read carefully the "ABASAGLAR KwikPen Instructions for Use" included with this package leaflet.
Natančno preberite Navodila za uporabo peresnika ABASAGLAR KwikPen, ki so vključena v to navodilo.
Disposing of pens and needles
Odlaganje peresnikov in igel
Tell a doctor straight away if you notice signs of severe allergic reaction.
Če opazite znake hude alergijske reakcije, takoj obvestite zdravnika.
Cartridges in use (in the insulin pen) or carried as a spare may be stored for a maximum of 28 days up to 30°C and away from direct heat or direct light.
Vložki, ki so v uporabi Vložke v uporabi (v insulinskem peresniku) ali vložke, ki jih imate pri sebi za rezervo, lahko shranjujete največ 28 dni pri temperaturi do 30 °C in zaščitene pred neposredno toploto in svetlobo.
You can give yourself multiple doses using one pen.
Z uporabo enega peresnika si lahko date več odmerkov.
At the last on-treatment visit, there was a mean increase in body weight from baseline of 1.4 kg in the insulin glargine group and a mean decrease of 0.8 kg in the standard care group.
Ob zadnjem obisku med zdravljenjem se je telesna masa od izhodišča v skupini z insulinom glargin povprečno povečala za 1,4 kg, in v skupini s standardnim zdravljenjem povprečno zmanjšala za
In clinical pharmacology studies, intravenous insulin glargine and human insulin have been shown to be equipotent when given at the same doses.
Klinične farmakološke študije so dokazale, da sta intravensko uporabljena insulin glargin in humani insulin v enakih odmerkih ekvipotentna.
Packs of 5 pens and multipacks containing 10 (2 packs of 5) pens .
Na voljo so pakiranja po 5 peresnikov in večja pakiranja, ki vsebujejo 10 peresnikov (2 pakiranji po 5
Shelf life after first use
Rok uporabnosti po prvi uporabi
Close metabolic monitoring is recommended during the switch and in the initial weeks thereafter.
Med prehodom in v prvih tednih po njem je potreben natančen nadzor presnove.
• Priming your pen means removing the air from the needle and cartridge that may collect during normal use and ensures that the pen is working correctly.
• Aktivacija zagotovi, da je peresnik pripravljen za uporabo in odstrani zrak, ki se lahko nabere v vložku pri običajni uporabi.
The patient should be advised to read the instructions for use included in the package leaflet carefully before using ABASAGLAR solution for injection in pre-filled pen.
Bolnikom je treba svetovati, naj pred uporabo zdravila ABASAGLAR raztopina za injiciranje v napolnjenem injekcijskem peresniku natančno preberejo navodila za uporabo na vloženem lističu.
If you think you may have a problem with ABASAGLAR, have it checked by your doctor or pharmacist.
Če se vam zdi, da imate težave z zdravilom ABASAGLAR, naj ga pregleda vaš zdravnik ali farmacevt.
The ABASAGLAR cartridges are to be used only in conjunction with a Lilly reusable insulin pen (see section 4.4).
Insulinski peresnik Vložke ABASAGLAR lahko uporabljate samo skupaj z insulinskim injekcijskim peresnikom Lilly za večkratno uporabo (glejte poglavje 4.4).
What ABASAGLAR looks like and contents of the pack
Izgled zdravila ABASAGLAR in vsebina pakiranja
• Select a new needle.
Izberite novo iglo.
Insulin administration may cause insulin antibodies to form.
Uporaba insulina lahko povzroči nastanek insulinskih protiteles.
Medication errors have been reported in which other insulins, particularly short-acting insulins, have been accidentally administered instead of insulin glargine.
O napakah zdravljenja so poročali, ko so bili drugi insulini, posebno kratko delujoči insulini,
It is completely soluble at the acidic pH of the ABASAGLAR injection solution (pH 4).
Pri kislem pH raztopine za injiciranje zdravila ABASAGLAR (pH 4) pa je popolnoma topen.
Pens in use must not be stored in the refrigerator.
Vložkov, ki jih uporabljate, ne smete shranjevati v hladilniku.
Preparing your Pen
Priprava vašega peresnika
The pen cap must be put back on the pen after each injection in order to protect from light.
Pokrovček peresnika morate po vsakem injiciranju namestiti nazaj na peresnik, da ga zaščitite pred svetlobo.
ABASAGLAR is used to treat diabetes mellitus in adults, adolescents and children aged 2 years and above.
Zdravilo ABASAGLAR se uporablja za zdravljenje sladkorne bolezni pri odraslih, mladostnikih in otrocih, starih 2 leti in več.
Read all of this leaflet carefully including the Instructions for Use of the ABASAGLAR KwikPen pre-filled pen, before you start using this medicine because it contains important information for you.
Pred začetkom uporabe zdravila natančno in v celoti preberite to navodilo, vključno z Navodili za uporabo napolnjenega injekcijskega peresnika ABASAGLAR KwikPen, ker vsebuje za vas pomembne podatke.
Substances that may enhance the blood-glucose-lowering effect and increase susceptibility to hypoglycaemia include oral antidiabetic medicinal products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase (MAO) inhibitors, pentoxifylline, propoxyphene, salicylates, somatostatin anologues and sulphonamide antibiotics.
Med zdravili, ki lahko stopnjujejo učinek znižanja glukoze v krvi in povečajo nagnjenost k hipoglikemiji, so peroralni antidiabetiki, zaviralci angiotenzinske konvertaze (ACE), dizopiramid, fibrati, fluoksetin, zaviralci monoaminooksidaze (MAO), pentoksifilin, propoksifen, salicilati, analogi somatostatina in sulfonamidni antibiotiki.
Physiological concentrations of endogenous IGF-1 may activate the mitogenicproliferative pathway; however, the therapeutic concentrations found in insulin therapy, including in ABASAGLAR therapy, are considerably lower than the pharmacological concentrations required to activate the IGF-1 pathway.
Vendar so terapevtske koncentracije med insulinskim zdravljenjem, vključno z zdravljenjem z zdravilom ABASAGLAR, bistveno manjše kot farmakološke koncentracije, potrebne za aktivacijo poti IGF-1.
As in the paediatric study described above, fasting plasma glucose reduction from baseline was greater in the insulin glargine group than in the NPH group.
Tako kot v zgoraj opisani pediatrični študiji je bilo tudi v tej študiji znižanje glukoze v plazmi na tešče v primerjavi z izhodiščem večje v skupini, ki je uporabljala insulin glargin, kot v skupini, ki je uporabljala insulin NPH.
- If you have missed a dose of ABASAGLAR or if you have not injected enough insulin, your blood sugar level may become too high (hyperglycaemia).
- Če ste izpustili odmerek zdravila ABASAGLAR ali če si niste injicirali dovolj insulina, se vam lahko koncentracija krvnega sladkorja preveč zviša (hiperglikemija).
MedDRA system organ classes
Organski sistemi po MedDRA
Dysgeusia
Disgevzija
The recovery of hypoglycaemia may be delayed because ABASAGLAR has a long action.'
Okrevanje po hipoglikemiji je zaradi dolgega delovanja zdravila ABASAGLAR lahko upočasnjeno.
• Do not try to change your dose while injecting.
• Med injiciranjem ne poskušajte spreminjati velikosti odmerka.
• KwikPen compatible needle (BD [Becton, Dickinson and Company] pen needles recommended).
• Igla, združljiva s peresnikom KwikPen (priporočamo igle za peresnik proizvajalca BD [Becton,
You should see insulin at the tip of the needle.
Na konici igle bi morali zagledati insulin.
Do not use it after this time period.
Ko to časovno obdobje preteče, ga ne uporabite več.
Mild episodes of hypoglycaemia can usually be treated with oral carbohydrates.
Blage hipoglikemije je običajno mogoče obvladati z uživanjem ogljikovih hidratov.
Solution for injection 5 cartridges of 3 mL.
raztopina za injiciranje 5 vložkov po 3 ml 10 vložkov po 3 ml
Packs of 5 and 10 cartridges.
Na voljo so pakiranja po 5 in 10 vložkov.
This leaflet was last revised in Other sources of information
Navodilo je bilo nazadnje revidirano.
ABASAGLAR comes in a special cartridge to be used only in a Lilly insulin pen.
Zdravilo ABASAGLAR je na voljo v posebnem vložku, ki je namenjen le uporabi v insulinskih peresnikih Lilly.
What should you do if you experience hypoglycaemia?
Kaj narediti, če se pojavi hipoglikemija?
Pre-filled pens in use or carried as a spare may be stored for a maximum of 28 days up to 30°C and away from direct heat or direct light.
Napolnjene peresnike v uporabi ali peresnike, ki jih imate pri sebi za rezervo, lahko shranjujete največ 28 dni pri temperaturi do 30 ° C in zaščitene pred neposredno toploto in svetlobo.
• Insert the needle into your skin.
Zabodite iglo v kožo.
It must only be used if the solution is clear, colourless, with no solid particles visible, and if it is of water-like consistency.
Uporabite ga le, če je raztopina v njem bistra, brezbarvna, ne vsebuje vidnih trdnih delcev in je vodi podobne konsistence.
____ insulin glargine
____ Insulin glargin
Medicines that may cause your blood sugar level to rise (hyperglycaemia) include:
Med zdravili, ki lahko povzročijo zvišanje koncentracije krvnega sladkorja (hiperglikemija), so:
Excipients: zinc oxide, metacresol, glycerol, hydrochloric acid and sodium hydroxide, water for injections
Pomožne snovi: cinkov oksid, metakrezol, glicerol, klorovodikova kislina in natrijev hidroksid, voda za injekcije
In patients with renal impairment, insulin requirements may be diminished due to reduced insulin metabolism.
Bolnikom z okvaro ledvic se lahko potreba po insulinu zmanjša zaradi zmanjšane presnove insulina.
Pack of 5
Pakiranje s 5 peresniki
Insulin antibodies
Insulinska protitelesa
PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON for multipack (with blue box) - KwikPen
PODATKI NA ZUNANJI OVOJNINI ZUNANJA OVOJNINA večje pakiranje (z modrim okencem)- peresnik KwikPen
Medicines that may cause your blood sugar level to fall (hypoglycaemia) include:
Med zdravili, ki lahko povzročijo znižanje koncentracije krvnega sladkorja (hipoglikemija) so:
Similar effects on glycohaemoglobin and the incidence of symptomatic hypoglycaemia were observed in both treatment groups, however fasting plasma glucose decreased more from baseline in the insulin glargine group than in the NPH group.
V obeh terapevtskih skupinah so ugotovili podobne učinke na glikirani hemoglobin in incidenco simptomatskih hipoglikemij, a glukoza v plazmi na tešče se je v primerjavi z izhodiščem v skupini z insulinom glargin zmanjšala bolj kot v skupini z insulinom NPH.V skupini, ki je uporabljala insulin glargin, je bilo tudi manj hudih hipoglikemij.
• Put used needles in a closable, puncture-resistant sharps container.
• Uporabljene igle odlagajte v zaprt vsebnik za ostre odpadke, ki je odporen proti vbodom.
• The pen will not let you dial more than the number of units left in the pen.
• Na peresniku ne morete nastaviti več enot, kot vam jih je še ostalo v peresniku.
- If you are not eating enough your blood sugar level may become too low (hypoglycaemia).
- Če ne jeste dovolj, se lahko koncentracija krvnega sladkorja preveč zniža (hipoglikemija).
ABASAGLAR is a long-acting insulin.
Zdravilo ABASAGLAR je dolgodelujoč insulin.
In the elderly, progressive deterioration of renal function may lead to a steady decrease in insulin requirements.
Starejša populacija (≥ 65 let) Pri starejših bolnikih lahko napredujoče slabšanje delovanja ledvic povzroči stalno zmanjševanje potrebe po insulinu.
- If you have injected too much ABASAGLAR, your blood sugar level may become too low (hypoglycaemia).
- Če ste injicirali preveč zdravila ABASAGLAR, se vam lahko koncentracija krvnega sladkorja preveč zniža (hipoglikemija).
Each pen contains 3 mL of solution for injection, equivalent to 300 units.
En vložek vsebuje 3 ml raztopine za injiciranje, kar ustreza 300 enotam.
Insulin label must always be checked before each injection to avoid medication errors between insulin glargine and other insulins (see section 4.4).
Da bi se izognili napakam zdravljenja zaradi zamenjave med insulinom glargin in drugimi insulini, je potrebno nalepko insulina vedno preveriti pred vsakim injiciranjem (glejte poglavje 4.4).
Examples of symptoms that indicate a low sugar level in the brain: headaches, intense hunger, nausea, vomiting, tiredness, sleepiness, sleep disturbances, restlessness, aggressive behaviour, lapses in concentration, impaired reactions, depression, confusion, speech disturbances (sometimes total loss of speech), visual disorders, trembling, paralysis, tingling sensations (paraesthesia), numbness and tingling sensations in the area of the mouth, dizziness, loss of self-control, inability to look after yourself, convulsions, loss of consciousness.
poslabšane reakcije, depresija, zmedenost, motnje govora (včasih popolna izguba govora), motnje vida, tresenje, paraliza, mravljinčenje (parestezije), omrtvelost in mravljinčenje v predelu ust, omotica, izguba nadzora nad seboj, nezmožnost poskrbeti zase, krči, izguba zavesti.
ABASAGLAR can be used in adolescents and children aged 2 years and above.
Zdravilo ABASAGLAR se lahko uporablja pri mladostnikih in otrocih, starih 2 leti in več.
Rubber Seal
Gumijasta zaporka
Do not use this medicine after the expiry date which is stated on the carton and on the label of the pen after “EXP”.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti , ki je naveden na škatli in nalepki peresnika poleg oznake EXP. Rok uporabnosti se izteče na zadnji dan navedenega meseca.
Each mL contains 100 units insulin glargine (equivalent to 3.64 mg).
1 ml vsebuje 100 enot insulina glargin (kar ustreza 3,64 mg).
Empty pens must never be reused and must be properly discarded.
Praznih peresnikov nikoli ne smete uporabiti znova, pač pa jih je treba ustrezno zavreči.
Do not use ABASAGLAR KwikPen if you notice particles in it. Only use ABASAGLAR KwikPen if the solution is clear, colourless and water-like.
Peresnik ABASAGLAR KwikPen uporabite le, če je raztopina bistra, brezbarvna in podobna vodi.
The warning symptoms of hypoglycaemia may be changed, be less pronounced or be absent in certain risk groups.
nekaterih ogroženih skupinah bolnikov se opozorilni simptomi hipoglikemije lahko spremenijo, postanejo manj izraziti ali jih sploh ni.Med takšne spadajo bolniki:
Your ability to concentrate or react may be reduced if: - you have hypoglycaemia (low blood sugar levels), - you have hyperglycaemia (high blood sugar levels), - you have problems with your sight.
- imate hipoglikemijo (nizko koncentracijo krvnega sladkorja), - imate hiperglikemijo (visoko koncentracijo krvnega sladkorja), - imate težave z vidom.
Each cartridge contains 3 mL of solution for injection, equivalent to 300 units.
En peresnik vsebuje 3 ml raztopine za injiciranje, kar ustreza 300 enotam.
Insulin receptor binding
Vezava na insulinske receptorje
- The active substance is insulin glargine.
- Učinkovina je insulin glargin.
For information on the treatment of hypoglycaemia, see box at the end of this leaflet.
Informacije o zdravljenju hiperglikemije najdete v okviru na koncu tega navodila za uporabo.
ABASAGLAR 100 units/mL solution for injection in a pre-filled pen, KwikPen, is a clear and colourless solution.
ABASAGLAR 100 enot/ml, raztopina za injiciranje v napolnjenem peresniku KwikPen, je bistra in brezbarvna raztopina.
• Pull off the outer needle shield.
• Odstranite zaščito zunanje igle.
• If your dose is more than 6080 units, you will need to give more than one injection.
• če je vaš odmerek več kot 60 80 enot, boste morali dati več kot eno injekcijo - V kolikor potrebujete pomoč kako razdeliti vaš odmerek, se posvetujte z vašim zdravnikom.
The pen in use must not be stored in the refrigerator.
Peresnika, ki ga uporabljate, ne smete shranjevati v hladilniku.
In the following situations, the management of your diabetes may require a lot of care (for example, adjustment to insulin dose, blood and urine tests): - If you are ill or have a major injury then your blood sugar level may increase (hyperglycaemia).
V sledečih okoliščinah lahko vodenje vaše sladkorne bolezni zahteva posebno skrb (npr. prilagoditev odmerka insulina, preiskave krvi in urina):
KwikPen 5 pens of 3 mL.
5 peresnikov po 3 ml.
HYPERGLYCAEMIA (high blood sugar levels) If your blood sugar is too high (hyperglycaemia), you may not have injected enough insulin.
Če je vaš krvni sladkor previsok (hiperglikemija), si morda niste vbrizgali dovolj insulina.
Each mL contains 100 units insulin glargine* (equivalent to 3.64 mg).
En mililiter vsebuje 100 enot insulina glargin* (kar ustreza 3,64 mg).
General disorders and administration site conditions Injection site reactions include redness, pain, itching, hives, swelling, or inflammation.
Reakcije na mestu injiciranja so pordelost, bolečine, srbenje, urtikarija, otekanje ali vnetje.
ABASAGLAR must not be mixed with any other insulin or medicinal products or diluted.
Zdravila ABASAGLAR se ne sme mešati z nobenim drugim insulinom ali drugim zdravilom in se ga ne sme redčiti.
Adherence of the patient to the dose and dietary regimen, correct insulin administration and awareness of hypoglycaemia symptoms are essential to reduce the risk of hypoglycaemia.
Za zmanjšanje tveganja za hipoglikemijo mora bolnik nujno upoštevati shemo odmerjanja in načrt prehrane, pravilno aplicirati insulin in poznati simptome hipoglikemije.
What should you do if you experience hyperglycaemia?
Kaj storiti, če se pojavi hiperglikemija?
There are no clinically relevant differences in serum insulin or glucose levels after abdominal, deltoid or thigh administration of insulin glargine.
Koncentracija insulina ali glukoze v serumu se klinično ne razlikujeta pomembno, če je insulin glargin injiciran v trebuh, deltoidni predel ali stegno.
Insulin glargine injected once daily will reach steady state levels in 2-4 days after the first dose.
Enkrat na dan injicirani insulin glargin doseže koncentracijo v stanju dinamičnega ravnovesja v 2 do 4
The exposure to M1 increases with the administered dose of insulin glargine.
Glavna spojina v plazmi je presnovek M1. Izpostavljenost presnovku M1 se povečuje z uporabljenim odmerkom insulina glargin.
Light grey with green ring on the end
- Gumb za odmerjanje: svetlo siv z zelenim obročem na koncu - Oznake: