natgillin/translations-raw huggingface dataset:
• The metabolism of propranolol is reduced by co-administration of quinidine, leading to a twothree-fold increased blood concentration and greater degrees of clinical beta-blockade.
• Presnovo propranolola zmanjšuje sočasna uporaba kinidina, ki povzroči od dva- do trikratno povečanje koncentracije v krvi in višje stopnje kliničnih beta blokad.
Patients with infantile haemangioma may be at increased risk if they have received or are concomitantly receiving treatment with corticosteroids because adrenal suppression may result in loss of the counterregulatory cortisol response and increase the risk of hypoglycaemia.
Pri bolnikih z infantilnim hemangiomom je morda povečano tveganje, če so bili zdravljeni ali se sočasno zdravijo s kortikosteroidi, saj lahko supresija nadledvične žleze privede do izgube protiregulatornega odziva na kortizol in poveča tveganje hipoglikemije.
In patients likely to experience severe anaphylactic reaction, regardless of origin, particularly with iodinated contrast agents, beta-blocker treatment may lead to worsening of the reaction and resistance to its treatment with adrenaline at normal doses.
Pri bolnikih, pri katerih obstaja verjetnost hude anafilaktične reakcije ne glede na izvor, zlasti pri uporabi jodiranih kontrastnih sredstev, lahko zdravljenje z antagonisti adrenergičnih receptorjev beta privede do poslabšanja reakcije in odpornosti na zdravljenje z adrenalinom v običajnih odmerkih.
• Sodium saccharin
• natrijev saharinat
Globally, the adverse reactions reported in the compassionate use program and in literature concerned hypoglycemia (and related event like hypoglycaemic seizure) and aggravated respiratory tract infections with respiratory distress.
Globalno so bili neželeni učinki, o katerih so poročali v programu sočutne uporabe in v literaturnih podatkih, hipoglikemija (in povezani dogodki, kot so hipoglikemične konvulzije) in poslabšanje okužbe dihal z dihalno stisko.
Mortality with unknown although unlikely relationship to treatment was observed at 40 mg/kg/day, leading to a NOAEL of 20 mg/kg/day for juvenile toxicity.
Smrtnost z neznano, čeprav malo verjetno povezanostjo z zdravljenjem je bila opažena pri odmerkih 40 mg/kg/dan, zaradi česar se za vrednost NOAEL za toksičnost za juvenilne živali smatra
• HEMANGIOL and the feed must be given by the same person in order to avoid the risk of hypoglycaemia.
• Zdravilo HEMANGIOL in hrano mora dati ista oseba, da se prepreči tveganje hipoglikemije.
- For bradycardia and hypotension: fatigue, coldness, pallor, bluish-coloured skin, and fainting.
- Za bradikardijo in hipotenzijo: utrujenost, hladnost, bledica, modrikasta koža in nezavest.
4 CLINICAL PARTICULARS 4.1 Therapeutic indications
4.1 Terapevtske indikacije
• Decreased blood sugar levels,
• znižana raven sladkorja v krvi,
Propranolol, due to its pharmacological action, may cause or worsen bradycardia or blood pressure abnormalities.
Propranolol lahko zaradi svojega farmakološkega učinkovanja povzroči ali poslabša bradikardijo ali nepravilnosti krvnega tlaka.
• The metabolism of intravenous lidocaine is inhibited by co-administration of propranolol, resulting in a 25% increase in lidocaine concentrations.
• Presnovo intravenoznega lidokaina zavira sočasna uporaba propranolola, posledica pa je 25odstotno povečanje koncentracije lidokaina.
• has a high blood pressure caused by a tumour on the adrenal gland.
• visok krvni tlak, ki ga povzroča tumor nadledvične žleze.
Discard the syringe once the bottle is finished.
Odvrzite brizgo, potem ko izpraznite steklenico.
Blood levels of propranolol may be decreased by co-administration of enzyme inducers like rifampicin or phenobarbital.
Induktorji encimov Koncentracije propranolola v krvi se lahko znižajo ob sočasni uporabi induktorjev encimov, kot sta rifampicin ali fenobarbital.
Duration of treatment:
Trajanje zdravljenja
Replace the plastic cap on the bottle by turning it clock-wise (to the right).
Namestite plastični pokrovček na steklenico, tako da ga zavrtite v smeri urnega kazalca (v desno).
In the event of lower respiratory tract infection associated with dyspnoea and wheezing, treatment should be temporarily discontinued.
V primeru okužbe spodnjih dihalnih poti, povezane z dispnejo in piskanjem v pljučih, je treba zdravljenje začasno prekiniti.
This medicine contains 2.08 mg of propylene glycol/kg/day.
To zdravilo vsebuje 2,08 mg propilenglikola/kg/dan.
In the absence of data in children, propranolol is not recommended in case of renal or hepatic impairment (see section 4.2).
Zaradi pomanjkanja podatkov pri otrocih ne priporočamo propranolola v primeru motenj delovanja ledvic ali jeter (glejte poglavje 4.2).
The advice of a cardiologist should be sought.
Posvetujte se s kardiologom.
If clinical signs of hypoglycaemia occur, it is necessary to make the child drink a sugary liquid solution and to temporarily stop the treatment.
Če se pojavijo klinični znaki hipoglikemije, mora otrok piti sladko raztopino in je zdravljenje treba začasno prekiniti.
HEMANGIOL contains sodium and propylene glycol
Zdravilo HEMANGIOL vsebuje natrij in propilenglikol
9 DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION
9 DATUM PRIDOBITVE/PODALJŠANJA DOVOLJENJA ZA PROMET Z ZDRAVILOM
Tell the your doctor that he/she is taking HEMANGIOL.
Povejte svojemu zdravniku, da otrok jemlje zdravilo HEMANGIOL.
HEMANGIOL should be administered directly into the child's mouth using the graduated oral syringe, calibrated in mg of propranolol base, supplied with the oral solution bottle (see instructions for use in section 3 of the patient information leaflet).
Zdravilo HEMANGIOL se daje neposredno v otrokova usta z uporabo graduirane brizge za peroralno dajanje, umerjene v miligramih propranolola, ki je priložena steklenici s peroralno raztopino (glejte navodila za uporabo v poglavju 3 navodil za uporabo).
In terms of reproductive development, growth and neurological development there were no propranolol-related effects or toxicologically significant findings at 40 mg/kg/day, correlating to safety margins of 1.2 in females and 2.9 in males, based on mean propranolol exposures on PND 21.
povezanih z propranololom, ali toksikološko pomembnih ugotovitev pri 40 mg/kg/dan, kar ustreza varnostni meji 1,2 pri samicah in 2,9 pri samcih, na osnovi povprečne izpostavljenosti propranololu na PND 21.
Third and following weeks (3 mg/kg/day)
Tretji teden in nadaljnji tedni (3 mg/kg/dan)
• has very low blood pressure.
• zelo nizek krvni tlak.
• Bronchitis (inflammation of the bronchi),
• bronhitis (vnetje sapnic (bronhijev)),
Heart rate (beats/min)
Srčni utrip (udarci/min) 100
HEMANGIOL may increase potassium blood level (hyperkaliemia).
Tveganje za hiperkaliemijo Zdravilo HEMANGIOL lahko poveča raven kalija v krvi (hiperkaliemija).
Interactions requiring precautions for use
Medsebojna delovanja, ki zahtevajo previdnostne ukrepe pri uporabi Kardiovaskularna zdravila
Clear, colourless to slightly yellow oral solution, with a fruity odour.
Prozorna, brezbarvna do rahlo rumena peroralna raztopina s sadnim vonjem.
Lidocaine toxicity (neurological and cardiac adverse events) has been reported following co-administration with propranolol.
Poročali so o toksičnosti lidokaina (nevrološki in srčni neželeni dogodki) zaradi sočasne uporabe s propranololom.
• Give HEMANGIOL directly into your child's mouth using the oral syringe supplied with the bottle.
• Zdravilo HEMANGIOL dajte neposredno v otrokova usta z uporabo peroralne brizge, ki je priložena steklenici.
Isolated cases of symptomatic bradycardia and hypotension have been reported in literature.
V literaturi so poročali o izoliranih primerih simptomatične bradikardije in hipotenzije.
Infants with hepatic or renal impairment
Dojenčki z motnjami delovanja jeter ali ledvic
Sympathetic stimulation may be a vital component supporting circulatory function in patients with congestive heart failure, and its inhibition by beta blockade may precipitate more severe failure.
Simpatična stimulacija je morda bistvena komponenta za podporo delovanju ožilja pri bolnikih s kongestivnim srčnim popuščanjem, njeno zaviranje z antagonisti adrenergičnih receptorjev beta pa lahko izzove še hujšo okvaro.
The readministration of propranolol may be considered when the child has fully recovered; in case of reoccurrence, treatment should be permanently discontinued.
S ponovnim dajanjem propranolola lahko nadaljujemo, ko otrok popolnoma ozdravi; če se znova pojavi,
• HEMANGIOL is a clear, colourless to slightly yellow oral solution, with a fruity odour.
• Zdravilo HEMANGIOL je prozorna, brezbarvna do rahlo rumena peroralna raztopina s sadnim vonjem.
Do not dismantle the syringe.
Brizge ne razstavljajte.
Propranolol belongs to a group of medicines known as beta-blockers.
Propranolol spada v skupino zdravil, znanih kot antagonisti adrenergičnih receptorjev beta.
The occurrence of diarrhea seems to be dose-dependent between 1 and 3 mg/kg/day.
Pojav driske je morebiti odvisen od odmerka med 1 in 3 mg/kg/dan.
In clinical trials for proliferating infantile haemangioma, the most frequently reported adverse reactions in infant treated with HEMANGIOL were sleep disorders (16.7%), aggravated respiratory tract infections such as bronchitis and bronchiolitis associated with cough and fever, diarrhoea (16.5%), and vomiting (11.5%).
Pri kliničnih preizkušanjih hitro rastočega infantilnega hemangioma so bili neželeni učinki, o katerih so največkrat poročali pri dojenčkih, zdravljenih z zdravilom HEMANGIOL, motnje spanja (16,7 %), poslabšanje okužb dihalnih poti, kot sta bronhitis in bronhiolitis, povezana s kašljem in z vročino,
The treatment of your child has been initiated by a physician who has expertise in the diagnosis, treatment and management of infantile haemangioma.
3 Kako otroku dajati zdravilo HEMANGIOL Z zdravljenjem vašega otroka je začel zdravnik, ki je strokovnjak za diagnosticiranje, zdravljenje in ravnanje z infantilnim hemangiomom.
In the absence of data, administration of the medicinal product is not recommended to infants with hepatic or renal impairment (see section 4.4).
Zaradi pomanjkanja podatkov dajanje zdravila ni priporočljivo za dojenčke z motnjami delovanja jeter ali ledvic (glejte poglavje 4.4).
Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate.
Tako glikozidi digitalisa kot antagonisti adrenergičnih receptorjev beta upočasnjujejo atrioventrikularno prevajanje in zmanjšujejo srčni utrip.
Hyperkaliemia cases have been reported in patients with large ulcerated hemangioma.
Obstajajo primeri hiperkaliemije pri bolnikih z velikim ulceriranim hemangiomom.
• It is supplied in a 120-mL amber glass bottle, with a child resistant screw-cap.
• Zdravilo je na voljo v 120-ml rjavorumeni steklenici s pokrovčkom, ki ga otroci ne morejo odpreti.
Second week (2 mg/kg/day)
Drugi teden (2 mg/kg/dan)
What HEMANGIOL looks like and contents of the pack
Izgled zdravila HEMANGIOL in vsebina pakiranja
10, rue Bouché Thomas ZAC d'Orgemont F-49000 Angers France
ZAC d'Orgemont F-49000 Angers Francija
- For hypoglycaemia: minor symptoms like pallor, tiredness, sweating, shakiness, palpitations, anxiety, hunger, difficulty waking up; major symptoms like excessive sleeping, difficulty to get a response, poor feeding, temperature decrease, convulsions (fits), brief pauses in breathing, loss of consciousness
- Za hipoglikemijo: blažji simptomi, npr. bledica, utrujenost, potenje, tresenje, palpitacije, tesnobnost, lakota, težave pri prebujanju; hujši simptomi, npr. čezmerno spanje, težave pri odzivnosti, slaba ješčost, padec telesne temperature, krči, kratki premori med dihanjem,
Insert tip of the oral syringe into the upright bottle and push the plunger all the way down.
Vstavite konico peroralne brizge v pokonci postavljeno steklenico in potisnite bat do konca navzdol.
- Instructions on when to discontinue the administration of HEMANGIOL
- navodili glede tega, kdaj prekiniti dajanje zdravila HEMANGIOL.
HEMANGIOL is to be given during or right after a feed to avoid the risk of hypoglycaemia.
HEMANGIOL je treba vzeti med obrokom ali takoj po njem, da se prepreči tveganje hipoglikemije.
Co-administration of cholestyramine or colestipol with propranolol resulted in up to 50% decrease in propranolol concentrations.
Zdravila za zniževanje ravni lipidov Sočasna uporaba holestiramina ali holestipola s propranololom je povzročila do 50-odstotno znižanje koncentracij propranolola.
Gastrointestinal disorders
Gastrointestinal ne motnje
First week (1 mg/kg/day)
Prvi teden (1 mg/kg/dan)
They may depress myocardial contractility and vascular compensating response when administered with propranolol.
Halogenirani anestetiki Zzmanjšajo lahko kontraktilnost miokarda in vaskularni kompenzatorni odgovor, če se uporabljajo s propranololom.
Propranolol crosses the blood-brain barrier and the placenta, and is distributed into breast milk.
Propranolol prehaja skozi krvno možgansko pregrado in placento in se porazdeli v materino mleko.
• has asthma or history of breathing difficulties.
• astmo ali je imel v preteklosti težave z dihanjem.
8 MARKETING AUTHORISATION NUMBER(S)
8 ŠTEVILKA (ŠTEVILKE) DOVOLJENJA (DOVOLJENJ) ZA PROMET Z ZDRAVILOM
• Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with β-blockers such as propranolol.
• Amiodaron je antiaritmik z negativnimi kronotropnimi lastnostmi, ki so lahko dodane antagonistom adrenergičnih receptorjev beta kot je propranolol.
HEMANGIOL and the feed must be given by the same person in order to avoid the risk of hypoglycaemia.
Zdravilo HEMANGIOL in hrano mora dati ista oseba, da se izognete tveganju hipoglikemije.
• Propafenone has negative inotropic and beta-blocking properties that can be additive to those of propranolol.
• Propafenon ima negativne inotropne lastnosti in lastnosti antagonistov adrenergičnih receptorjev beta, ki so lahko aditivne lastnostim propranolola.
It is necessary to alert the anaesthetist to the fact that the patient is being treated with beta-blockers.
Anestezista je treba opozoriti na dejstvo, da je bolnik zdravljen z antagonisti adrenergičnih receptorjev beta.
• has circulation problems which make the toes and fingers numb and pale.
• težave s krvnim obtokom, zaradi katerih postanejo prsti na nogah in rokah otrpli in bledi.
Call your doctor right away if your child has any signs such as tiredness, coldness, pallor, bluish-coloured skin, or fainting while taking HEMANGIOL.
Takoj pokličite zdravnika, če pri otroku med uporabo zdravila HEMANGIOL opazite kakršne koli znake, npr. utrujenost, hladnost, bledico, modrikasto kožo ali omedlevica.
Non-cardiovascular medicinal products
Zdravila, ki niso kardiovaskularna
Administration of protein-rich foods increases the bioavailability of propranolol by about 50% with no change in time to peak concentration.
Dajanje hrane, bogate z beljakovinami, poveča biološko uporabnost propranolola za približno 50 %
Hemangiol is started in infants aged 5 weeks to 5 months, when: - the localisation and/or extend of the lesions are life- or function threatening (might impair vital organs or senses such as vision or hearing); - the haemangioma is ulcerated (i.e. with sore on the skin which fails to heal) and painful, and/or does not respond to simple wound care measures; - there is a risk of permanent scars or disfigurement.
- je mesto in/ali razširjenost poškodb nevarno za življenje ali delovanje telesa (lahko ogroža vitalne organe ali čutila, kot so vid ali sluh), - je hemangiom ulceriran (npr. razjeda na koži, ki se ne zaceli) in boleč in/ali se ne odziva na enostavne ukrepe pri oskrbi rane, - obstaja tveganje za trajne brazgotine ali izmaličenje.
Do not use a spoon or any other dispensing device.
Ne uporabljajte žlice ali kakršne koli druge priprave za odmerjanje.
• Medicines for heart and blood vessels problems such as uneven heart beats, chest pain or angina,
• zdravila za težave s srcem in ožiljem, npr. neenakomeren utrip srca, bolečine v prsnem košu ali angina pektoris, visok krvni tlak, srčno popuščanje,
• a reduction of both VEGF and bFGF signalling pathways and subsequent angiogenesis /
• učinek sprožanja apoptoze pri kapilarnih endotelnih celicah • zmanjšanje signalnih poti VEGF in bFGF ter posledično angiogenezo/proliferacijo.
3- Discard the water into your sink
2- Povlecite bat 3- Odstranite vodo v umivalnik
Pharmacotherapeutic group: Beta-Blocking agent, non-selective, ATC code: C07AA05
Farmakoterapevtska skupina: Antagonisti adrenergičnih receptorjev beta, neselektivni, oznaka ATC:
• Life- or function-threatening haemangioma,
• hemangiom, ki ogroža življenje ali telesne funkcije,
Risks of bronchospasm
Tveganje za bronhospazem
• Hemangiol is for oral use.
• Zdravilo HEMANGIOL se daje peroralno.
Hyperkaliemia
Hiperkaliemija
• is prone to low blood sugar level.
• nagnjen k nizkim ravnem sladkorja v krvi.
120 mL solution, in a type III amber-glass bottle fitted with a low density polyethylene insert and a child resistant polypropylene screw cap, provided with a polypropylene oral syringe graduated in mg of propranolol base.
120 ml raztopina v rjavorumeni steklenici tipa III, opremljeni z vložkom iz polietilena nizke gostote in za otroke varno polipropilensko navojno zaporko, priložena je polipropilenska peroralna brizga,
• Severe peripheral arterial circulatory disturbances (Raynaud's phenomenon)
• Prinzmetalova angina pektoris • Hude motnje perifernega arterijskega obtoka (Raynaudov fenomen)
Liver or kidney failure
Odpoved jeter ali ledvic
• Vanilla flavour (contains propylene glycol)
• aroma vanilje (vsebuje propilenglikol)
PIERRE FABRE MEDICAMENT PRODUCTION Site PROGIPHARM, Rue du Lycée 45500 GIEN
Site PROGIPHARM, Rue du Lycée
The mixing may be done with one teaspoonful (approximately 5 mL) of milk for children weighing up to 5 kg, or with a tablespoonful (approximately 15 mL) of milk or fruit juice for children weighing more than 5 kg, delivered in a baby's bottle.
Za otroke, ki tehtajo do 5 kg, lahko naredite mešanico z eno čajno žličko mleka (približno 5 ml), za otroke, ki tehtajo več kot 5 kg, pa mešanico z jedilno žlico mleka ali sadnega soka (približno 15 ml) in jo daste iz dojenčkove stekleničke.
See section 2 under ‘HEMANGIOL contains sodium and propylene glycol' for further information.
Za več informacij glejte poglavje 2 pod »Zdravilo HEMANGIOL vsebuje natrij in propilenglikol«.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist or nurse.
Če imate dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
• This medicine has been prescribed for your child only.
• Zdravilo je bilo predpisano vašemu otroku in ga ne smete dajati drugim.
The posology is expressed in propranolol base.
Odmerjanje je izraženo v količini propranolola.
• Elevated level of potassium in the blood
• povišana raven kalija v krvi.
For children weighing more than 5 kg the dose may be mixed with a tablespoonful of milk or fruit juice (approximately 15 mL).
Za otroke, ki tehtajo več kot 5 kg, lahko odmerek zmešate z jedilno žlico mleka ali sadnega soka (približno 15 ml).
If your child gets any side effects, talk to your doctor or pharmacist.
Če pri vašem otroku opazite kateri koli neželeni učinek, se posvetujte z zdravnikom ali s farmacevtom.
HEMANGIOL can decrease blood pressure (hypotension) and heart rate (bradycardia).
Tveganje za hipotenzijo in bradikardijo (počasen srčni utrip) Zdravilo HEMANGIOL lahko zniža krvni tlak (hipotenzija) in srčni utrip (bradikardija).
Close the bottle.
• 8. korak Zaprite steklenico.
The bottle should not be shaken before use.
Steklenice pred uporabo ne smete pretresti.
• Strawberry flavour (contains propylene glycol)
• aroma jagode (vsebuje propilenglikol)
For children weighing up to 5 kg you may mix the dose with one teaspoonful of milk (approximately 5 mL).
Za otroke, ki tehtajo do 5 kg, lahko odmerek zmešate z eno čajno žličko mleka (približno 5 ml).
Bradycardia -inducing calcium-channel blockers (diltiazem, verapamil, bepridil) Co-administration with propranolol can cause altered automaticity (excessive bradycardia, sinus arrest), sino-atrial and atrio-ventricular conduction disorders, and increased risk of ventricular arrhythmias (torsades de pointes) along with heart failure.
Sočasna uporaba s propranololom lahko povzroči spremenjen avtomatizem (čezmerno bradikardijo, sinusni zastoj), motnje pri sinoatrijskem in atrioventrikularnem prevajanju in povečano tveganje ventrikularne aritmije (torsades de pointes) sočasno s srčnim popuščanjem.
• Constipation, abdominal pain,
• zaprtje, bolečine v trebuhu,
Treatment with HEMANGIOL should be initiated by physicians who have expertise in the diagnosis, treatment and management of infantile haemangioma, in a controlled clinical setting where adequate facilities for handling of adverse reactions, including those requiring urgent measures, are available.
zdravljenju in oskrbi infantilnega hemangioma, v nadzorovanem bolnišničnem okolju, kjer je na voljo dovolj ustrezne opreme za obravnavo neželenih reakcij, vključno s tistimi, ki zahtevajo takojšnje ukrepanje.
Warnings and precautions Before your child receives HEMANGIOL, tell your doctor:
Preden daste vašemu otroku zdravilo HEMANGIOL, povejte zdravniku:
If you have any further questions, ask your doctor or pharmacist.
Če imate dodatna vprašanja, se posvetujte z zdravnikom ali s farmacevtom.
7 MARKETING AUTHORISATION HOLDER
7 IMETNIKI DOVOLJENJA ZA PROMET Z ZDRAVILOM
Urticaria Alopecia
Koprivnica Alopecija
Propranolol is metabolized through three primary routes: aromatic hydroxylation (mainly 4hydroxylation), N-dealkylation followed by further side-chain oxidation, and direct glucuronidation.
Propranolol se presnavlja po treh primarnih poteh: aromatska hidroksilacija (večinoma 4
How to give HEMANGIOL to your child
Kako dajati zdravilo HEMANGIOL otroku
Caution should be exercised when patients receiving a beta blocker are administered a dihydropyridine.
Previdnost je potrebna pri bolnikih, ki med prejemanjem antagonistov adrenergičnih receptorjev beta, prejmejo dihidropiridin.
• Information on the correct procedure of product preparation and administration including:
• podatke o pravilnem postopku priprave zdravila in dajanja, vključno z: - navodili za pripravo raztopine z zdravilom HEMANGIOL,
Propranolol is a beta-blocker that is characterised by three pharmacological properties:
Farmakodinamični učinki Propranolol je antagonist adrenergičnih receptorjev beta, ki ga zaznamujejo tri farmakološke lastnosti:
Important warning signs of potential side effects such as low blood pressure, low heart rate, low blood sugar level, and bronchospasm (breathing difficulties) should be looked after following administration of HEMANGIOL.
Po dajanju zdravila HEMANGIOL je treba biti pozoren na pomembne opozorilne znake morebitnih neželenih učinkov, npr. nizek krvni tlak, nizek srčni utrip, nizko raven sladkorja v krvi in bronhospazem (težave z dihanjem).
If you have given to your child more HEMANGIOL than you should, please consult your doctor immediately.
Če ste otroku dali večji odmerek zdravila HEMANGIOL, kot bi smeli Če ste otroku dali večji odmerek zdravila HEMANGIOL, kot bi smeli, se takoj posvetujte z zdravnikom.
Cardiovascular disorders
Kardiovaskularne motnje
2 What you need to know before your child receives HEMANGIOL Do not give HEMANGIOL
2 Kaj morate vedeti, preden vaš otrok prejme zdravilo HEMANGIOL Ne uporabljajte zdravila HEMANGIOL Če je/ima vaš otrok:
Decreased heart rate
Zmanjšan srčni utrip Nevtropenija
Propranolol is almost completely absorbed after oral administration.
Propranolol se po peroralni uporabi skoraj popolnoma absorbira.
• Major: excessive sleeping, difficulty responding, poor feeding, decrease in body temperature,
• večji: čezmerno spanje, težave pri odzivnosti, slaba ješčost, padec telesne temperature, krči, kratki premori med dihanjem, izguba zavesti.
• Decreased appetite,
• zmanjšan tek,
Turn bottle upright and remove the entire syringe from the bottle.
• 7. korak Odstranjevanje brizge Steklenico obrnite v pokončen položaj in v celoti odstranite brizgo iz steklenice.
Propranolol is highly lipid-soluble and may cross the blood brain barrier and cause seizures.
Propranolol je močno topen v maščobi in lahko prehaja skozi krvno-možgansko pregrado ter povzroči konvulzije.