natgillin/translations-raw huggingface dataset:
Steady state plasma levels of amitriptyline + nortriptyline are reached within a week for most patients, and in steady state the plasma level comprises approximately equal parts of amitriptyline and nortriptyline around the clock following treatment with conventional tablets 3 times a day.
Plazemska koncentracija amitriptilina + nortriptilina v stanju dinamičnega ravnovesja je pri večini bolnikov dosežena v enem tednu, plazemska koncentracija v stanju dinamičnega ravnovesja po 24 urah je pri zdravljenju z običajnimi tabletami trikrat na dan.v približno enakih delih sestavljena iz amitriptilina in nortriptilina.
• halofantrine (used to treat malaria)
• halofantrin (uporablja se za zdravljenje malarije)
Do not stop the treatment without consulting your doctor first.
Ne prenehajte uporabljati zdravila, ne da bi se posvetovali z zdravnikom.
• narrow angle glaucoma (loss of vision due to abnormally high pressure in the eye)
• glavkom ozkega zakotja (izgubo vida zaradi nenormalno visokega tlaka v očesu)
Depending on your response to the medicine, your doctor may gradually increase the dose.
Glede na vaš odziv na zdravilo lahko zdravnik odmerek postopno poveča.
The dosage therefore can be increased in 25 mg amitriptyline hydrochloride steps>.
Odmerek se lahko zato povečuje postopno po 25 mg amitriptilinijevega klorida.>
Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucraseisomaltase insufficiency should not receive this medicine.>
Bolniki z redko dedno intoleranco za fruktozo, malabsorpcijo glukoze/galaktoze ali pomanjkanjem saharoza-izomaltaze ne smejo jemati tega zdravila.>
If you have taken this medicine during the last part of the pregnancy, the newborn may have withdrawal symptoms such as irritability, increased muscle tension, tremor, irregular breathing, poor drinking, loud crying, urinary retention, and constipation.
Če ste to zdravilo jemali v zadnjem obdobju nosečnosti, se bodo mordapri novorojenčku pojavili odtegnitveni simptomi, kot so razdražljivost, povečana mišična napetost, tremor, neredno dihanje, slabo pitje, glasno jokanje, zastajanje seča in zaprtje.
If necessary, the dose can be increased by 25 mg every other day up to 150 mg daily divided into two doses.
Po potrebi se lahko odmerek poveča po 25 mg vsak drugi dan do 150 mg na dan, razdeljeno na dva odmerka.
Do not give this medicine to children and adolescents aged below 18 years for these treatments, as safety and efficacy have not been established in this age group.
Tega zdravila ne dajajte otrokom in mladostnikom, mlajšim od 18 let, ker pri tej starostni skupini varnost in učinkovitost nista bili dokazani.
After prolonged administration, abrupt cessation of therapy may produce withdrawal symptoms such as headache, malaise, insomnia and irritability.
Po daljši uporabi lahko nenadno prenehanje zdravljenja povzroči odtegnitvene simptome, kot so glavobol, splošno slabo počutje, nespečnost in razdražljivost.
In the listing below the following convention is used: MedDRA system organ class / preferred term Very common (> 1/10);
V spodnji preglednici je uporabljen naslednji dogovor: Organski sistemi/prednostni izraz po MedDRA;
Known poor metabolisers of CYP2D6 or CYP2C19
Znani slabi presnavljalci s CYP2D6 ali CYP2C19
Cytochrome P450 inhibitors of CYP2D6
Zaviralci citokroma P450 CYP2D6
paresthesia, ataxia.
• driska, bruhanje
• epilepsy, a history of convulsions or fits
• epilepsijo, konvulzije ali krče v anamnezi
CNS depressants: Amitriptyline may enhance the sedative effects of alcohol, barbiturates and other CNS depressants.
Zaviralci osrednjega živčevja: Amitriptilin lahko poveča sedativne učinke alkohola, barbituratov in drugih zaviralcev osrednjega živčevja.
• rifampicin (to treat infections)
• rifampicin (uporablja se za zdravljenje okužb)
All the metabolites have less anticholinergic activity than amitriptyline and nortriptyline.
Vsi presnovki imajo šibkejše antiholinergično delovanje kot amitriptilin in nortriptilin.
Cytochrome P450 inducers: Oral contraceptives, rifampicin, phenytoin, barbiturates, carbamazepine and St. John's Wort (Hypericum perforatum) may increase the metabolism of tricyclic antidepressants and result in lowered plasma levels of tricyclic antidepressants and reduced antidepressant response.
Induktorji citokroma P450: Peroralni kontraceptivi, rifampicin, fenitoin, barbiturati, karbamazepin in šentjanževka (Hypericum perforatum) lahko povečajo presnovo tricikličnih antidepresivov in povzročijo zmanjšanje ravni tricikličnih antidepresivov v plazmi in zmanjšan odziv na antidepresive.
The daily dose may be increased up to 100 mg - 150 mg divided into two doses, depending on individual patient response and tolerability.
Dnevni odmerek se lahko povečuje do 100 mg - 150 mg, razdeljeno na dva odmerka, odvisno od odziva posameznega bolnika in prenašanja.
Patients with a history of suicide-related events, or those exhibiting a significant degree of suicidal ideation prior to commencement of treatment, are known to be at greater risk of suicidal thoughts or suicide attempts, and should receive careful monitoring during treatment.
Znano je, da je tveganje za samomorilne misli ali poskuse samomora pri bolnikih z anamnezo s samomorom povezanih dogodkov, in pri bolnikih, ki kažejo samomorilno mišljenje že pred začetkom zdravljenja, večje, zato jih je treba med zdravljenjem skrbno nadzirati.
Check urea and electrolytes-look for low potassium and monitor urine output.
Preverjanje vrednosti sečnine in elektrolitov - posebna pozornost glede nizkih vrednosti kalija in izločanja urina.
injection
injiciranje
Examine for clinical features.
Klinični pregled.
NAME OF THE MEDICINAL PRODUCT Saroten and associated names 2 ml, 50 mg solution for injection
IME ZDRAVILA Saroten in povezana imena 2 ml, 50 mg raztopina za injiciranje
• St. John´s Wort (hypericum perforatum) - a herbal remedy used for depression
• šentjanževka (Hypericum perforatum) - rastlinski pripravek, ki se uporablja za zdravljenje depresije
<[Saroten and associated names prolonged-release capsules, hard ] When the prolonged-release capsules are administered in the evening the concentration of amitriptyline is highest late in the night and decreases during the day whilst the concentration of nortriptyline is constant around the clock and thus predominates during daytime.
<[Saroten in povezana imena trde kapsule s podaljšanim sproščanjem] Pri dajanju kapsul s podaljšanim sproščanjem zvečer je koncentracija amitriptilina največja pozno ponoči, nato pa se čez dan zmanjšuje, medtem ko je koncentracija nortriptilina konstantna 24 ur in prevladuje tekom dneva.>
The dosage therefore can be increased in 25 mg amitriptyline hydrochloride steps.
Odmerek se lahko zato povečuje postopno po 25 mg amitriptilinijevega klorida.
The mean absolute oral bioavailability is 53% (Fabs = 0.527±0.123; range 0.219-0.756).
Povprečna absolutna biološka uporabnost je 53 % (Fabs = 0,527 ± 0,123; razpon
- A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG).
• težava s srcem, imenovana »podaljšanje intervala QT« (to je vidno na elektrokardiogramu,
• diabetes as you might need and adjustment of your antidiabetic medicine.
• sladkorno bolezen, saj bo morda treba prilagoditi odmerke vaših zdravil za zdravljenje sladkorne bolezni.
• severe heart disease
• hudo bolezen srca
Oral administration of tablets results in maximum serum levels in about 4 hours.
Maksimalne koncentracije v serumu so bile dosežene v približno 4 urah po peroralni uporabi tablet.
The tablets are swallowed with water independent of meals.>
Tablete pogoltnite cele z vodo, ne glede na obroke hrane.>
If your doctor has told you that you have intolerance to some sugars, contact your doctor before taking this medicine.>
Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred uporabo tega zdravila posvetujte s svojim zdravnikom.>
Potential of other medicinal products to affect amitriptyline
Možnost vpliva drugih zdravil na delovanje amitriptilina
Your doctor will decide when and how to stop your treatment to avoid any unpleasant symptoms that might occur if it is stopped abruptly (e.g. headache, feeling unwell, sleeplessness and irritability).
Zdravnik se bo odločil, kdaj in kako boste prenehali zdravljenje, da se prepreči pojav morebitnih neprijetnih simptomov, ki se lahko pojavijo pri nenadnem prenehanju (npr. glavobol, slabo počutje, nespečnost in razdražljivost).
• medicines to treat fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole)
• zdravila za zdravljenje glivičnih okužb (npr. flukonazol, terbinafin, ketokonazol in itrakonazol)
Not known (cannot be estimated from the available data).
Neznana (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti).
Warnings and precautions Talk to your doctor or pharmacist before taking X.
Opozorila in previdnostni ukrepi Preden prejmete zdravilo X, se posvetujte z zdravnikom ali farmacevtom.
Amitriptyline is a sedative drug.
Amitriptilin je pomirjevalo.
Do not use this medicine after the expiry date which is stated on the label afterr EXP.
Tega zdravila ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na nalepki poleg oznake EXP. Rok uporabnosti zdravila se izteče na zadnji dan navedenega meseca.
<[Saroten and associated names 75 mg, modified release tablets] In contrast to the tablet serum curves which show a distinct initial peak, the modified release tablets curves rise slowly to a plateau level with lower concentrations than the peak of the tablet curves.
<[Saroten in povezana imena 75 mg, tablete s prirejenim sproščanjem] V nasprotju s krivuljami serumske koncentracije za tablete, ki kažejo izrazit začetni vrh, se krivulje tablet s prirejenim sproščanjem počasi dvigajo do platoja, kjer so koncentracije nižje, kot je vrh krivulj za tablete.
Usually the X is added to a solution for infusion.
Običajno se zdravilo X doda k raztopini za infundiranje.
If your doctor has told you that you have intolerance to some sugars, contact your doctor before taking this medicine.
Če vam je zdravnik povedal, da ne prenašate nekaterih sladkorjev, se pred uporabo tega zdravila posvetujte s svojim zdravnikom.
Amitriptyline and the main metabolite nortriptyline pass across the placental barrier.
Amitriptilin in njegov glavni presnovek nortriptilin prehajata skozi placento.
The mean systemic clearance (Cls) is 51.5 ±13.8 l/h, range 25.6-71.8 l/h.
Povprečni sistemski očistek (Cls) je 51,5 ± 13,8 l/h, razpon 25,6 - 71,8 l/h.
Great care is necessary if amitriptyline is administered to hyperthyroid patients or to those receiving thyroid medication, since cardiac arrhythmias may develop.
Pri dajanju amitriptilina bolnikom s hipertirozo ali bolnikom, ki prejemajo zdravila za zdravljenje ščitnice, je potrebna velika previdnost, saj lahko pride do srčnih aritmij.
• hypersensitivity inflammation of heart muscle
• preobčutljivostno vnetje srčne mišice
Severe liver disease.
Huda bolezen jeter.
Lowered consciousness progressing into coma.
zmanjšana zavest, ki napreduje v komo, depresija dihanja.
• medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics)
• zdravila za zdravljenje nekaterih bolezni srca (npr. zaviralci beta in antiaritmiki)
This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.
To zdravilo smejo predpisovati samo zdravniki z izkušnjami pri obravnavi trdovratne enureze.
CYP2D6 inhibitors: The CYP2D6 isozyme can be inhibited by a variety of drugs, e.g. neuroleptics, serotonin reuptake inhibitors, beta blockers, and antiarrhythmics.
Zaviralci CYP2D6: Izoencim CYP2D6 lahko zavirajo številna zdravila, npr. nevroleptiki, zaviralci ponovnega privzema serotonina, zaviralci adrenergičnih receptorjev beta in antiaritmiki.
The mechanism of action also includes ion-channel blocking effects on sodium, potassium and NMDA channel at both central and spinal cord level.
Mehanizem delovanja vključuje tudi zaviralni učinek ionskih kanalov na kanale natrija, kalija in
Thioridazine: Co-administration of amitriptyline and thioridazine (CYP2D6 substrate) should be avoided due to inhibition of thioridazine metabolism and consequently increased risk of cardiac side effects
Tioridazin: Sočasnemu dajanju amitriptilina in tioridazina (substrat CYP2D6) se je treba izogibati zaradi zaviranja presnove tioridazina in posledično povečanega tveganja za neželene učinke na srce.
It is advisable to review all antihypertensive therapy during treatment with tricyclic antidepressants.
Med zdravljenjem s tricikličnimi antidepresivi je priporočljivo spremljati antihipertenzivno zdravljenje.
The antidepressant and analgesic effects usually set in after 2-4 weeks; the sedative action is not delayed.
Antidepresivni in analgetični učinki običajno nastopijo po 2 do 4 tednih; sedativno delovanje ni zakasnjeno.
Daily doses above 100 mg should be used with caution.
Dnevne odmerke, večje od 100 mg, je treba uporabljati previdno.
• increased sensitivity to sunlight
• večja občutljivost na sončno svetlobo • povečanje dojk pri moških
The antidepressant effect usually sets in after 2 - 4 weeks.
Trajanje zdravljenja Antidepresivni učinek običajno nastopi po 2 - 4 tednih.
The recommended initial dose is 25 mg two times daily.
Priporočeni začetni odmerek je 25 mg dvakrat na dan.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucosegalactose malabsorption should not receive this medicine.
Bolniki z redko dedno intoleranco za galaktozo, laponsko obliko zmanjšane aktivnosti laktaze ali malabsorpcijo glukoze/galaktoze ne smejo jemati tega zdravila.
Patients (and caregivers of patients) should be alerted about the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.
Bolnike (in njihove negovalce) je treba opozoriti, da je potreben nadzor glede kliničnega poslabšanja, samomorilnega vedenja ali misli,
The daily dosage is in general between 1 and 3 ampoules of 2 ml (equivalent to 50-150 mg amitriptyline hydrochloride/day, equivalent to 44.2 - 132.6 mg amitriptyline/day).
Dnevni odmerek je običajno 1 do 3 ampule po 2 ml (kar ustreza 50 - 150 mg amitriptilinijevega klorida na dan, kar ustreza 44,2 - 132,6 mg amitriptilina na dan).
• Suicidal thoughts and behaviours may also develop during early treatment with antidepressants for disorders other than depression; the same precautions observed when treating patients with depression should therefore be followed when treating patients with enuresis
• V zgodnjem obdobju zdravljenja z antidepresivi za druge motnje kot depresijo se lahko pojavijo samomorilne misli in vedenje, zato je treba pri zdravljenju bolnikov z enurezo upoštevati iste previdnostne ukrepe kot pri zdravljenju bolnikov z depresijo.
After oral administration of 50 mg the mean Cmax =21.5±9.0 ng/ml; range 13.2-35.8 ng/ml (77.5±32.4 nmol/L).>
Po peroralni aplikaciji 50 mg je povprečna Cmax = 21,5 ± 9,0 ng/ml; razpon 13,2 - 35,8 ng/ml (77,5 ± 32,4 nmol/l).>
Doses can be increased with 10 mg - 25 mg every 3 - 7 days as tolerated.
Odmerke je mogoče povečati po 10 mg ali 25 mg na vsake 3 do 7 dni, kot jih bolnik prenaša.
Amitriptyline for enuresis should not be combined with an anticholinergic drug.
Za zdravljenje enureze amitriptilina ni dovoljeno kombinirati z drugimi antiholinergiki.
The score line facilitates breaking of the retard tablet into 3 parts.
Razdelilna zareza olajša lomljenje tablete s podaljšanim sproščanjem na 3 dele.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Če imate dodatna vprašanja o uporabi tega zdravila, se posvetujte z zdravnikom ali farmacevtom.
• if you have heart problems such as disturbances in heart rhythm which are seen on an electrocardiogram (ECG), heart block, or coronary artery disease
• če imate težave s srcem, kot so motnje srčnega ritma, kar je vidno na elektrokardiogramu
Dose to be administered 1-1½ hours before bedtime.
Odmerek je treba dati 1 - 1,5 ure pred spanjem.
METHOD OF ADMINISTRATION Solution for i.v.
POSTOPEK UPORABE raztopina za i.v.
After peroral administration of 50 mg the mean Cmax = 30.95±9.61 ng/ml; range 10.85-45.70 ng/ml (111.57±34.64 nmol/l; range 39.06-164.52 nmol/l).
Po peroralni aplikaciji 50 mg je povprečna Cmax = 30,95 ± 9,61 ng/ml; razpon 10,85 - 45,70 ng/ml (111,57 ± 34,64 nmol/l; razpon 39,06164,52 nmol/l).
The recommended initial dose is 50 mg in the evening.
Priporočeni začetni odmerek je 50 mg zvečer.
The antidepressant effect usually sets in after 2-4 weeks; the sedative action is not delayed.
Antidepresivni učinek običajno nastopi po 2 do 4 tednih; sedativno delovanje ni zakasnjeno.
Anticholinergic agents: Tricyclic antidepressants may potentiate the effects of these drugs on the eye, central nervous system, bowel and bladder; concomitant use of these should be avoided due to an increased risk of paralytic ileus, hyperpyrexia, etc.
Antiholinergična zdravila: Triciklični antidepresivi lahko okrepijo učinke teh zdravil na oko, osrednje živčevje, črevesje in mehur; sočasni uporabi se je treba izogibati zaradi povečanega tveganja za paralitični ileus, hiperpireksijo itd.
• aged 11 years and above: 25 mg - 50 mg.
• stare 11 let in več: 25 mg - 50 mg.
If you have any further questions on the use of this prodcut, ask your doctor, pharmacist or nurse.
Če imate dodatna vprašanja o uporabi tega zdravila, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
The noradrenaline, sodium and the NMDA effects are mechanisms known to be involved in the maintenance of neuropathic pain, chronic tension type headache prophylaxis and migraine prophylaxis.
Za noradrenalin, natrij in NMDA je znano, da sodelujejo pri vzdrževanju nevropatske bolečine, preprečevanju kroničnega glavobola tenzijskega tipa in preprečevanju migrene.
An increased risk of bone fractures has been observed in patients taking this type of medicines.
Pri bolnikih, ki so jemali to vrsto zdravil, so opazili povečano tveganje za zlome kosti.
• thioridazine (used to treat schizophrenia)
• tioridazin (uporablja se za zdravljenje shizofrenije)
Weakened patients, patients with cerebral or cardiac impairment, as well as patients with poor circulation, breathing problems, impaired liver function or advanced renal impairment a dose reduction is recommended.
Bolniki s posebnimi dejavniki tveganji Pri oslabelih, bolnikih z možgansko ali srčno okvaro in pri bolnikih s slabo prekrvavitvijo, težavami z dihanjem, okvaro jeter ali napredovalo okvaro ledvic se priporoča zmanjšanje odmerka.
• children aged 11 years and above: 25 mg - 50 mg daily
• otroci, stari 11 let in več: 25 mg - 50 mg na dan
Bone marrow depression, agranulocytosis, leucopenia, eosinophilia, thrombocytopenia.
Bolezni krvi in limfatičnega sistema redki depresija kostnega mozga, agranulocitoza, levkopenija, eozinofilija, trombocitopenija.
• the treatment of neuropathic pain in adults
• zdravljenje nevropatske bolečine pri odraslih
Common (> 1/100, < 1/10);
Pogosti (> 1/100, < 1/10);
Amitriptyline should be used with caution in patients receiving SSRIs (see sections 4.2 and 4.5).
Pri bolnikih, ki prejemajo selektivne zaviralce ponovnega privzema serotonina, je treba amitriptilin uporabljati previdno (glejte poglavji 4.2 in 4.5).
Children are especially susceptible to cardiotoxicity and seizures.
Za kardiotoksičnost in epileptične napade so dovzetni predvsem otroci.
Other isozymes involved in the metabolism of amitriptyline are CYP3A4, CYP1A2 and CYP2C9.
Drugi izoencimi, ki sodelujejo pri presnovi amitriptilina, so CYP3A4, CYP1A2 in CYP2C9.
When stopping therapy the drug should be gradually withdrawn during several weeks.
Pri prenehanju zdravljenja je treba odmerek zdravila zmanjševati postopno več tednov.
• ritonavir (used to treat HIV)
• ritonavir (uporablja se za zdravljenje okužb z virusom HIV)
Other Cytochrome P450 inhibitors: Cimetidine, methylphenidate and calcium-channel blockers (e.g. diltiazem and verapamil) may increase plasma levels of tricyclic antidepressants and accompanying toxicity.
Drugi zaviralci citokroma P450: Cimetidin, metilfenidat in zaviralci kalcijevih kanalčkov (npr. diltiazem in verapamil) lahko povečajo ravni tricikličnih antidepresivov v plazmi in posledično njihovo toksičnost.
If you were given more X then you should
Če ste dobili večji odmerek zdravila X, kot bi smeli
• aged 6 to 10 years: 10 mg - 20 mg daily.
• stare od 6 do 10 let: 10 mg - 20 mg na dan.
<[Saroten and associated names 75 mg, modified release tablets] When the modified-release tablets are administered in the evening the concentration of amitriptyline is highest late in the night and decreases during the day whilst the concentration of nortriptyline is constant around the clock and thus predominates during daytime.>
<[Saroten in povezana imena 75 mg tablete s prirejenim sproščanjem] Pri dajanju tablet s prirejenim sproščanjem zvečer je koncentracija amitriptilina največja pozno ponoči, nato pa se čez dan zmanjšuje, medtem ko je koncentracija nortriptilina konstantna 24 ur in prevladuje tekom dneva.>
• schizophrenia
• shizofrenijo
Any degree of heart block or disorders of cardiac rhythm and coronary artery insufficiency.
Nedavno preboleli miokardni infarkt; katera koli stopnja srčnega bloka ali motnje srčnega ritma in koronarna insuficienca.
The daily dosage is in general between 1and 3 ampoules of 2 ml (equivalent to 50-150 mg amitriptyline hydrochloride/day).
Dnevni odmerek je običajno 1 do 3 ampule po 2 ml (kar ustreza 50 - 150 mg amitriptilinijevega klorida na dan).
Close supervision of patients and in particular those at high risk should accompany drug therapy especially in early treatment and following dose changes.
Pri zdravljenju s tem zdravilom je treba na začetku in po spremembah odmerka bolnike skrbno nadzorovati, predvsem tiste, pri katerih obstaja veliko tveganje.
The metabolism is subject to genetic polymorphism (CYP2D6 and CYP2C19) (see section 4.2).
Presnova je odvisna od genetskega polimorfizma (CYP2D6 in CYP2C19) (glejte poglavje 4.2).
Cases of QT interval prolongation and arrhythmia have been reported during the post-marketing period.
V obdobju trženja so poročali o podaljšanju intervala QT in aritmijah.
Secure an IV access.
Zagotovitev i.v.
This medical product should be used with caution in patients with convulsive disorders, urinary retention, prostatic hypertrophy, hyperthyroidism, paranoid symptomatology and advanced hepatic or cardiovascular disease, pylorus stenosis and paralytic ileus.
Bolniki s konvulzijami, zastojem seča, hipertrofijo prostate, hipertiroidizmom, paranoidnimi simptomi in napredovalo boleznijo jeter ali srčno-žilno boleznijo, stenozo pilorusa in paralitičnim ileusom morajo to zdravilo uporabljati previdno.
Drugs which prolong the QT-interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide and sertindole), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants.
Zdravila, ki podaljšajo interval QT, vključno z antiaritmiki, kot je kinidin, antihistaminikoma astemizolom in terfenadinom, nekaterimi antipsihotiki (zlasti pimozid in sertindol), cisaprid,
- Attacks of intermittent blurring of vision, rainbow vision, and eye pain.
• izmenični napadi zamegljenega vida, mavrični krogi okrog izvorov svetlobe in bolečine v očesu
• abnormality in the heart's rhythm, or heartbeat pattern
• nenormalen srčni ritem ali srčni utrip
Doses above 100 mg should be used with caution.
Odmerke, večje od 100 mg, je treba uporabljati previdno.
• monoamine oxidase inhibitors (MAOIs) e.g. phenelzine, iproniazid, isocarboxazid, nialamide or tranylcypromine (used to treat depression) or selegiline (used to treat Parkinson's disease).
• zaviralci monoaminooksidaze npr. fenelzin, iproniazid, izokarboksazid, nialamid ali tranilcipromin (uporabljajo se za zdravljenje depresije) ali selegilin (uporablja se za zdravljenje Parkinsonove bolezni).
Not known Hepatitis.
neznana pogostnost hepatitis
Consider gastric lavage only if within one hour of a potentially fatal overdose.
Izpiranje želodca je smiselno opraviti le v prvi uri prevelikega odmerka, ki je lahko smrten.