natgillin/translations-raw huggingface dataset:
Glimepiride has a very low distribution volume (approximately 8.8 litres) which is roughly equal to the albumin distribution space, high protein binding (> 99%), and a low clearance (approximately 48 mL/min).
Glimepirid ima zelo nizek volumen porazdelitve (približno 8,8 litrov), kar je približno enako površini porazdelitve albumina, visoko vezavo na beljakovine (99%) in nizek očistek (približno 48 ml/min).
Ask your doctor or pharmacist for more information if you are not sure how to recognise this and what you should do if you experience the symptoms.
Vprašajte svojega zdravnika ali farmacevta za dodatne informacije, če niste prepričani, kako prepoznati to stanje in kaj morate storiti, če se pojavijo simptomi.
In diabetic patients, good metabolic control over 24 hours can be achieved with a single daily dose.
Pri diabetikih je mogoče dobro 24-urno presnovno urejenost doseči z enim samim odmerkom na dan.
Pharmacokinetics were similar in males and females, as well as in young and elderly (above 65 years) patients.
Farmakokinetike so bile podobne pri moških in ženskah ter pri mlajših in starejših (nad 65 let) bolnikih.
Although in very rare cases fatal outcome has been reported, causal relationship has not been established.
Čeprav so poročali o zelo redkih primerih s smrtnim izidom, vzročna povezanost ni bila ugotovljena.
What you need to know before you take Tandemact
Kaj morate vedeti, preden boste vzeli zdravilo Tandemact
Comparison of single and multiple once-daily dosing revealed no significant differences in pharmacokinetics, and the intra-individual variability was very low.
Primerjava med jemanjem odmerkov enkrat in večkrat na dan ni pokazala nobenih pomembnih razlik v farmakokinetiki, intraindividualna variabilnost pa je bila zelo nizka.
- if you have problems with your enzyme called Glucose-6-phosphodehydrogenase since it can decrease your red cells.
- če imate težave z encimom, imenovanim glukoza-6-fosfodehidrogenaza, ker lahko le-ta zmanjša število rdečih krvnih telesc.
This study showed an increase in reports of heart failure; however this did not lead to an increase in mortality in this study.
Študija je pokazala povečano število poročil o srčnem popuščanju; vendar pa v tej študiji to ni povzročilo povečane smrtnosti.
Although the hydroxy metabolite of glimepiride caused a small but significant decrease in serum glucose in healthy persons, it accounts for only a minor part of the total effect.
Čeprav je hidroksi-presnovek glimepirida povzročil majhno, a pomembno znižanje glukoze v serumu zdravih ljudi, to predstavlja le manjši del celotnega učinka zdravila.
There have been no formal interaction studies for Tandemact, however, the concomitant use of the active substances in patients in clinical use has not resulted in any unexpected interactions.
Formalne raziskave o interakcijah za zdravilo Tandemact niso bile narejene, vendar sočasno jemanje učinkovin pri bolnikih pri klinični uporabi ni povzročilo nobenih nepričakovanih interakcij.
Take Tandemact daily as prescribed.
Jemljite zdravilo Tandemact vsak dan, kakor vam je predpisano.
There may be an increased possibility of becoming pregnant because you may ovulate again when you take Tandemact.
Obstaja lahko povečana možnost zanositve, saj lahko pride do ponovne ovulacije, ko vzamete zdravilo Tandemact.
6 Elevation of liver enzymes may occur.
6 Jetrni encimi se lahko zvišajo.
The safety and efficacy of Tandemact in children and adolescents under 18 years of age have not been established.
Varnost in učinkovitost zdravila Tandemact pri otrocih in mladostnikih, mlajših od 18 let, še nista bili dokazani.
These findings were observed across species at plasma concentrations  4 times the clinical exposure.
Te ugotovitve so potrdila opažanja pri vseh vrstah pri plazemskih koncentracijah  4-kratne plazemske koncentracije pri klinični izpostavitvi.
After ingestion of an overdose of glimepiride, hypoglycaemia may occur, lasting from 12 to 72 hours, and may recur after initial recovery.
Po zaužitju prevelikega odmerka glimepirida se lahko pojavi hipoglikemija, ki traja od 12 do 72 ur in se lahko po navideznem okrevanju ponovi.
very rare very rare
zelo redki zelo redki
After high doses, slightly longer half-lives were noted.
Po višjih odmerkih so bili opaženi malce daljši razpolovni časi.
Other medicines and Tandemact
Druga zdravila in zdravilo Tandemact
- if you have a special type of diabetic eye disease called macular oedema (swelling of the back of the eye), talk to your doctor if you notice any change to your vision.
- če imate posebno obliko diabetične očesne bolezni imenovano makularni edem (otekanje zadnjega dela očesa), če opazite kakršnokoli spremembo vida, se posvetujte z zdravnikom.
Your blood sugar level can be increased by taking sugar.
Raven sladkorja v krvi se lahko poveča tako, da vzamete sladkor.
very rare very rare allergic vasculitis2
zelo redki zelo redki alergijski vaskulitis2
In the latter (covering embryotoxicity, teratogenicity and developmental toxicity), undesirable effects observed were considered to be secondary to the hypoglycaemic effects induced by the compound in dams and in offspring.
Pri slednjem (ki zajema embriotoksičnost, teratogenost in razvojno toksičnost) so bili opaženi neželeni učinki sekundarni hipoglikemičnim učinkom, ki jih je sestavina povzročila pri samicah in potomcih.
Your doctor may take blood tests to monitor your blood cell levels and liver function.
Zdravnik se lahko odloči za krvne preiskave, da preveri raven krvnih celic in delovanje jeter.
Immune system disorders allergic shock2
Bolezni imunskega sistema alergijski šok2
Severe hypoglycaemia or prolonged hypoglycaemia, only temporarily controlled by the usual amounts of sugar, require immediate medical treatment and occasionally hospitalisation.
V primeru hude ali podaljšane hipoglikemije, ki jo je moč le začasno nadzirati z običajnimi količinami sladkorja, je potrebno takojšnje zdravljenje in včasih hospitalizacija.
Rare (may affect up to 1 in 1,000 people) - noticeable changes in blood
Redki (pojavijo se lahko pri največ 1 od 1.000 bolnikov) - opazne spremembe v krvi
Two metabolites - most probably resulting from hepatic metabolism (major enzyme is CYP2C9) - were identified both in urine and faeces: the hydroxy derivative and the carboxy derivative.
Dva metabolita - verjetno zaradi jetrne presnove (glavni encim je CYP2C9) - sta bila najdena tako v urinu kot tudi v blatu: hidroksi-derivat in karboksi-derivat.
Cross allergenicity with sulphonylureas, sulphonamides or related substances is possible.
Možna je navzkrižna alergenost s sulfonilsečninami, sulfonamidi ali sorodnimi snovmi.
Tell your doctor or pharmacist if you are taking any of these.
Obvestite zdravnika ali farmacevta, če jemljete katero od teh zdravil.
If you have a serious allergic reaction, including hives and swelling of the face, lips, tongue, or throat that may cause difficulty in breathing or swallowing stop taking this medicine and talk to your doctor immediately.
Če imate resno alergijsko reakcijo, ki vključuje koprivnico in otekanje obraza, ustnic, jezika ali grla, ki lahko povzroča težave z dihanjem ali požiranjem, takoj prenehajte z jemanjem tega zdravila in se nemudoma pogovorite s svojim zdravnikom.
This is particularly important in those who have reduced or absent awareness of the warnings of hypoglycaemia or have frequent episodes of hypoglycaemia.
To je posebej pomembno pri bolnikih z zmanjšanim ali odsotnim zaznavanjem opozorilnih znakov hipoglikemije in pri tistih, ki imajo pogoste hipoglikemije.
In particular when treating hypoglycaemia due to accidental intake of Tandemact in infants and young children, the dose of glucose given must be carefully controlled to avoid the possibility of producing dangerous hyperglycaemia.
Zlasti pri zdravljenju hipoglikemije zaradi akcidentalnega zaužitja zdravila Tandemact pri dojenčkih in majhnih otrocih, je treba odmerek glukoze skrbno nadzirati, da bi se izognili možnosti za pojav nevarne hiperglikemije.
Tandemact helps control the level of sugar in your blood when you have type 2 diabetes by increasing the amount of insulin available and helping your body make better use of it.
Zdravilo Tandemact pomaga nadzorovati raven sladkorja v krvi, če imate sladkorno bolezen tipa 2, in sicer tako, da povečuje količino insulina, ki je na voljo in telesu pomaga bolje izkoristiti insulin.
As with other sulphonylureas this effect is based on an increase of responsiveness of the pancreatic beta cells to the physiological glucose stimulus.
Tako kot pri drugih sulfonilsečninah ta učinek temelji na izboljšani odzivnosti pankreatičnih celic beta na fiziološki glukozni stimulus.
In light of age-related risks (especially bladder cancer, fractures and heart failure), the balance of benefits and risks should be considered carefully both before and during treatment in the elderly.
Glede na s starostjo povezana tveganja (zlasti rak mehurja, zlomi in srčno popuščanje), je treba pri starejših ravnovesje med koristmi in tveganji skrbno pretehtati pred in med zdravljenjem.
The following statements reflect the pharmacokinetic properties of the individual active substances of Tandemact.
Naslednje ugotovitve odražajo farmakokinetične lastnosti individualnih učinkovin v zdravilu Tandemact.
This type 2 diabetes usually develops in adulthood where the body either does not produce enough insulin (a hormone that controls blood sugar levels), or cannot effectively use the insulin it produces.
Sladkorna bolezen tipa 2 se običajno razvije v odrasli dobi, ko telo ali ne proizvaja dovolj insulina (hormon, ki nadzira raven sladkorja v krvi) ali pa ne more učinkovito uporabiti proizvedenega insulina.
However if you miss a dose, skip the missed dose and just carry on with the next dose as normal.
Če pa pozabite vzeti odmerek, preskočite pozabljeni odmerek in nadaljujte z naslednjim odmerkom kot sicer.
This is a serious reaction which may occur uncommonly (≥ 1/1,000 to < 1/100) (see section 4.4).
To je resna reakcija, ki se lahko pojavi občasno (≥ 1/1.000 do < 1/100) (glejte poglavje 4.4).
Takeda Ireland Limited, Bray Business Park, Kilruddery, County Wicklow, Ireland Delpharm Novara S.r.l., Via Crosa, 86, 28065 Cerano (NO), Italy Takeda GmbH, Production Site Oranienburg, Lehnitzstrasse 70 - 98, 16515 Oranienburg, Germany
Takeda Ireland Limited, Bray Business Park, Kilruddery, County Wicklow, Irska Delpharm Novara S.r.l., Via Crosa, 86, 28065 Cerano (NO), Italija Takeda GmbH, Production Site, Oranienburg, Lehnitzstrasse 70 - 98, 16515 Oranienburg, Nemčija
Epidemiological studies have also suggested a small increased risk of bladder cancer in diabetic patients treated with pioglitazone, although not all studies identified a statistically significant increased risk.
Tudi epidemiološke študije, kažejo malo večje tveganje za rak mehurja pri bolnikih s sladkorno boleznijo zdravljenih s pioglitazonom, čeprav pri vseh študijah povečanje tveganja ni bilo statistično signifikantno
Patients should be observed for signs and symptoms of heart failure, weight gain or oedema; particularly those with reduced cardiac reserve.
Bolnike je treba opazovati glede znakov in simptomov srčnega popuščanja, povišanja telesne mase ali edemov; posebno tiste z zmanjšano srčno rezervo.
Risk related to glimepiride
Tveganje, povezano z glimepiridom
There are no adequate data from the use of glimepiride in pregnant women.
Ni zadostnih podatkov o uporabi glimepirida pri nosečnicah.
5 Gastro-intestinal complaints are very rare and seldom lead to discontinuation of therapy.
5 Bolezni prebavil so zelo redke in redko povzročijo prekinitev zdravljenja.
No increase in mortality from heart failure was observed.
Dviga smrtnosti zaradi srčnega popuščanja niso opazili.
When you take Tandemact, your blood sugar could fall below the normal level (hypoglycaemia).
Ko boste vzeli zdravilo Tandemact, lahko krvni sladkor pade pod normalno raven (hipoglikemija).
In very rare cases, impairment of liver function (e.g. with cholestasis and jaundice) may develop, as well as hepatitis which may progress to liver failure.
V zelo redkih primerih se lahko razvije okvara delovanja jeter (npr. s holestazo in zlatenico) ter hepatitis, ki lahko napreduje v odpoved jeter.
Do not use Tandemact if you are breastfeeding or are planning to breast-feed (see section “Do not take Tandemact”).
Ne jemljite zdravila Tandemact če dojite ali nameravate dojiti (glejte poglavje “Ne jemljite zdravila Tandemact”).
Takeda GmbH Production Site Oranienburg Lehnitzstrasse 70 - 98 16515 Oranienburg, Germany
Takeda GmbH Production Site Oranienburg Lehnitzstrasse 70 - 98, 16515 Oranienburg, Nemčija
14 tablets 28 tablets 30 tablets 50 tablets 90 tablets 98 tablets
14 tablet 28 tablet 30 tablet 50 tablet 90 tablet 98 tablet
The recommended dose is one tablet taken once daily shortly before or with the first main meal.
Priporočeni odmerek je ena tableta dnevno neposredno pred ali s prvim glavnim obrokom.
Food intake has no relevant influence on absorption, only absorption rate is slightly diminished.
Vnos hrane nima pomembnega vpliva na absorpcijo, deloma se zniža hitrost absorpcije.
In animals, glimepiride is excreted in milk.
Pri živalih se glimepirid izloča v mleku.
8 Oedema was reported in 6-9% of patients treated with pioglitazone over one year in controlled clinical trials.
8 O edemih so poročali pri 6-9% bolnikov, zdravljenih s pioglitazonom leto dni v kontroliranih kliničnih preskušanjih.
The uptake of glucose from blood into peripheral muscle and fat tissues occurs via a special transport proteins, located in the cells membrane.
Prenos glukoze iz krvi v periferna mišična in maščobna tkiva poteka preko posebnih transportnih proteinov, ki se nahajajo v membrani celic.
The transport of glucose in these tissues is the rate limiting step in the use of glucose.
Transport glukoze v ta tkiva je stopnja, ki omejuje hitrost uporabe glukoze.
Maximum serum concentrations (Cmax) are reached approximately 2.5 hours after oral intake (mean 0.3 µg/mL during multiple dosing of 4 mg daily).
Maksimalne koncentracije v serumu (Cmax) so dosežene približno 2,5 uri po peroralnem jemanju (v povprečju 0,3 µg/ml med večkratnim odmerjanjem po 4 mg dnevno).
Start the administration of glucose as soon as possible, if necessary by a bolus intravenous injection of 50 ml of a 50% solution, followed by an infusion of a 10% solution with strict monitoring of blood glucose.
Takoj, ko je mogoče začnite z dajanjem glukoze, po potrebi z intravensko bolusno injekcijo 50 ml 50% raztopine, ki ji sledi infuzija 10% raztopine s skrbnim spremljanjem glukoze v krvi.
The tablets are supplied in aluminium/aluminium blister packs containing either 14, 28, 30, 50, 90 or 98 tablets.
Tablete so na voljo v aluminij/aluminij pretisnih omotih, ki vsebujejo bodisi 14, 28, 30, 50, 90 ali 98 tablet.
Cases of bladder cancer were reported more frequently in a meta-analysis of controlled clinical trials with pioglitazone (19 cases from 12,506 patients, 0.15%) than in control groups (7 cases from 10,212 patients, 0.07%) HR=2.64 (95% CI 1.11-6.31, p=0.029).
O primerih raka mehurja, so pogosteje poročali v meta-analizi kontroliranih kliničnih preskušanjih s pioglitazonom (19 primerov od 12.506 bolnikov, 0,15%) kot v kontrolnih skupinah (7 primerov od 10.212 bolnikov, 0,07%) HR = 2,64 (95% IZ 1,11-6,31, p = 0,029).
If patients report hypoglycaemia, the dose of Tandemact should be reduced or free combination therapy should be considered.
Če bolniki poročajo o hipoglikemiji, je treba odmerek zdravila Tandemact znižati ali razmisliti o kombinacijski terapiji.
Patients should be aware of the risk of pregnancy and if a patient wishes to become pregnant or if pregnancy occurs, the treatment should be discontinued (see section 4.6).
Zato se morajo tveganja za zanositev zavedati, in če bolnica želi zanositi ali če zanosi, je treba zdravljenje prekiniti (glejte poglavje 4.6).
Tandemact may either increase or weaken the effects of the following medicines: - coumarin derivatives such as warfarin (to slow down or stop blood clotting)
Zdravilo Tandemact lahko bodisi poveča ali zmanjša učinek naslednjih zdravil: - derivati kumarina, kot je varfarin (za upočasnitev ali ustavitev strjevanja krvi)
Animal studies have shown reproductive toxicity which was most likely related to the pharmacological action (hypoglycaemia) of glimepiride.
Študije na živalih so pokazale reproduktivno toksičnost, ki je bila najverjetneje povezana s farmakološkim delovanjem (hipoglikemija) glimepirida.
After a single dose of radiolabelled glimepiride, 58% of the radioactivity was recovered in the urine, and 35% in the faeces.
Po enkratnem odmerku radioaktivno označenega glimepirida, se je 58% radioktivnosti izločilo v urinu in 35% v blatu.
Linearity/non-linearity Single dose studies demonstrate linearity of pharmacokinetics in the therapeutic dose range.
Linearnost/nelinearnost Študije z enkratnimi odmerki kažejo linearnost farmakokinetike v terapevtskem razponu odmerkov.
Interactions with substances metabolised by these enzymes, e.g. oral contraceptives, cyclosporin, calcium channel blockers, and HMGCoA reductase inhibitors are not to be expected.
Interakcij s snovmi, ki jih presnavljajo ti encimi, npr. s peroralnimi kontraceptivi, ciklosporinom, zaviralci kalcijevih kanalčkov in inhibitorji HMGCoA reduktaze, ni pričakovati.
There are no adequate data from the use of pioglitazone in pregnant women.
Ni zadostnih podatkov o uporabi pioglitazona pri nosečnicah.
If ALT levels are increased to 3 x upper limit of normal during Tandemact therapy, liver enzyme levels should be reassessed as soon as possible.
Če se med zdravljenjem z zdravilom Tandemact ravni ALT zvišajo do 3-kratne zgornje meje normalnih vrednosti, je treba ravni jetrnih encimov čim prej ponovno kontrolirati.
4 Visual disturbance has been reported mainly early in treatment and is related to changes in blood glucose due to temporary alteration in the turgidity and refractive index of the lens as seen with other hypoglycaemic medicinal products.
4 O motnjah vida so poročali predvsem zgodaj v poteku zdravljenja, povezane pa so s spremembami vrednosti glukoze v krvi zaradi začasnih sprememb turgidnosti in refrakcijskega indeksa leče, kot jih opažamo tudi pri drugih hipoglikemičnih zdravilih.
Risk related to pioglitazone
Tveganje, povezano s pioglitazonom
The fracture incidence calculated was 1.9 fractures per 100 patient years in women treated with pioglitazone and 1.1 fractures per 100 patient years in women treated with a comparator.
Izračunana incidenca zlomov je bila 1,9 zlomov na 100 bolnikovih let pri ženskah, zdravljenih s pioglitazonom in 1,1 zlom na 100 bolnikovih let pri ženskah, zdravljenih s primerjalnim zdravilom.
Tandemact should not be used in patients with severe renal function disorders (creatinine clearance < 30 ml/min, see section 4.3).
Zdravila Tandemact se ne sme uporabljati pri bolnikih s hudo motnjo ledvičnega delovanja (očistek kreatinina < 30 ml/min, glejte poglavje 4.3).
Blood and lymphatic system disorders changes in haematology1
Bolezni krvi in limfatičnega sistema hematološke spremembe1
In patients with low creatinine clearance, there was a tendency for glimepiride clearance to increase and for average serum concentrations to decrease, most probably resulting from a more rapid elimination because of lower protein binding.
Pri bolnikih z nizkim očistkom keratina, je bila tendenca, da se očistek glimepirida poveča in povprečne serumske koncentracije zmanjšajo, kar verjetno izhaja iz hitrejšega izločanja zaradi manjše vezave na beljakovine.
After excluding patients in whom exposure to study drug was less than one year at the time of diagnosis of bladder cancer, there were 7 cases (0.06%) on pioglitazone and 2 cases (0.02%) in control groups.
Ko so izločili bolnike, ki so bili v času diagnoze rak mehurja, preiskovanemu zdravilu izpostavljeni manj kot eno leto, so ugotovili 7 primerov (0,06%) raka mehurja pri pioglitazonu in 2 primera (0,02%) v kontrolnih skupinah.
Extrapancreatic activity
Ekstrapankreatično delovanje
In animal fertility studies with pioglitazone, there was no effect on copulation, impregnation or fertility index.
V študijah plodnosti s pioglitazionom na živalih, niso opazili vpliva na indeks kopulacije, impregnacije ali plodnosti.
In addition, glimepiride seems to have pronounced extrapancreatic effects also postulated for other sulphonylureas.
Poleg tega kaže, da ima glimepirid izrazite ekstrapankreatične učinke, ki jih imajo domnevno tudi druge sulfonilsečnine.
This finding is based on conventional safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenicity, and reproduction toxicity studies.
To je bilo ugotovljeno na osnovi običajnih študij farmakološke varnosti, toksičnosti pri ponavljajočih se odmerkih, genotoksičnosti, rakotvornosti in reproduktivne toksičnosti.
When treating patients who have at least one risk factor for development of congestive heart failure (e.g. prior myocardial infarction or symptomatic coronary artery disease or the elderly), physicians should start with the lowest available dose of pioglitazone and increase the dose gradually.
Pri zdravljenju bolnikov z vsaj enim dejavnikom tveganja za razvoj kongestivnega srčnega popuščanja (tj. pred miokardnim infarktom ali simptomatsko boleznijo koronarnih arterij ali v primeru starejših bolnikov), mora zdravnik začeti z najnižjim možnim odmerkom pioglitazona in ga postopoma zviševati.
There is a linear relationship between dose and both Cmax and AUC (area under the time/concentration curve).
Med odmerkom ter Cmax in AUC obstaja linearna povezanost (površina pod krivuljo koncentracije zdravila in časa).
The decision whether to continue the patient on therapy with Tandemact should be guided by clinical judgement pending laboratory evaluations.
Odločitev o tem, ali zdravljenje bolnika z zdravilom Tandemact nadaljevati, naj do laboratorijskih vrednotenj temelji na klinični presoji.
Tandemact with alcohol
Zdravilo Tandemact skupaj z alkoholom
The patient's ability to concentrate and react may be impaired as a result of hypoglycaemia or hyperglycaemia from glimepiride or, for example, as a result of visual impairment.
Bolnikova zmožnost koncentracije in reagiranja se lahko poslabša zaradi hipoglikemije ali hiperglikemije povezane z glimepiridom, pa tudi npr. zaradi prizadetosti vida.
Hypoglycaemic reactions mostly occur immediately due to the sulphonylurea component of Tandemact.
Hipoglikemične reakcije se največkrat pojavijo takoj zaradi sulfonilsečnine, ki je sestavina zdravila Tandemact.
Not known (frequency can not be estimated from the available data) - increase in liver enzymes - itchy skin - raised and itchy rash (hives)
Neznani (pogostnosti iz razpoložljivih podatkov ni mogoče oceniti) - povišanje jetrnih encimov - srbečica kože - izbočen in srbeč izpuščaj (koprivnica)
If you have the impression that the effect of Tandemact is too weak, talk to your doctor.
Če menite, da je učinek zdravila Tandemact prešibak, se posvetujte z zdravnikom.
NAME OF THE MARKETING AUTHORISATION HOLDER Takeda (logo)
IME IMETNIKA DOVOLJENJA ZA PROMET Z ZDRAVILOM Takeda (logo)
What Tandemact is and what it is used for What you need to know before you take Tandemact How to take Tandemact
Kaj je zdravilo Tandemact in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Tandemact Kako jemati zdravilo Tandemact Možni neželeni učinki
Passage of the blood brain barrier is low.
Prehajanje preko krvno-možganske pregrade je počasno.
Treatment of patients with G6PD-deficiency with sulfonylurea agents can lead to haemolytic anaemia.
Zdravljenje bolnikov s pomanjkanjem G6PD z derivati sulfonilsečnine, lahko povzroči hemolitično anemijo.
Treatment with Tandemact therefore requires regular haematological monitoring (especially leucocytes and platelets).
Zato je pri zdravljenju z zdravilom Tandemact potrebno redno hematološko spremljanje (predvsem levkocitov in trombocitov).
After oral administration of glimepiride, the terminal half-lives of those metabolites were 3 to 6 and 5 to 6 hours respectively.
Po peroralni uporabi glimepirida je bil razpolovni čas teh presnovkov od 3 do 6 ur in od 5 do 6 ur.