natgillin/translations-raw huggingface dataset:
Talk to your doctor if you suffer from cancer or if your teeth are in bad condition as this is a risk factor.
Posvetujte se z zdravnikom, če imate raka ali so vaši zobje v slabem stanju, ker je to dejavnik tveganja.
The majority of the reports refer to cancer patients, but such cases have also been reported in patients treated for osteoporosis.
Večina poročil se nanaša na bolnike z rakom, vendar pa so o takih primerih poročali tudi pri bolnikih, ki so se zdravili za osteoporozo.
If you have been told by your doctor that you have an intolerance to some sugars (for example lactose), contact your doctor before taking this medicine.
Če vam je zdravnik povedal, da imate intoleranco za nekatere sladkorje (na primer laktozo), se pred jemanjem tega zdravila posvetujte s svojim zdravnikom.
3) Do not lie down - stay fully upright (sitting, standing or walking) - for at least 30 minutes after swallowing the tablet.
3) Ne uležite se - ostanite v popolnoma pokončnem položaju (sedite, stojte ali hodite) - še najmanj 30 minut potem, ko ste pogoltnili tableto.
This might be a symptom of osteonecrosis (death of bone tissue).
To je lahko simptom osteonekroze (odmrtja kostnega tkiva).
The physician should therefore be alert to any signs or symptoms of possible oesophageal reaction.
Zdravnik mora biti zato pozoren na kakršnekoli znake ali simptome, ki opozarjajo na možno reakcijo v požiralniku.
Alendronate HEXAL should not be given to children and adolescents.
Zdravila Alendronat HEXAL se ne sme dajati otrokom in mladostnikom.
Long-term use of steroids is often associated with the development of osteoporosis accompanied by fractures.
Dolgotrajna uporaba steroidov je pogosto povezana z razvojem osteoporoze, ki jo spremljajo zlomi.
Please see package leaflet for further information.
Za dodatne informacije glejte priloženo navodilo.
Plasma concentrations fell by more than 95% within 6 hours following intravenous administration.
Plazemske koncentracije so v šestih urah po intravenski aplikaciji padle za več kot 95%.
Although these usually hurt, breaks in the bones of the spine may go unnoticed until they cause height loss.
Čeprav so ti običajno boleči, pa lahko zlomi kosti v hrbtenici minejo neopaženo, dokler ne povzročijo znižanja telesne višine.
See also section 4.4 .
Glejte tudi poglavje 4.4.
- Do not take with mineral water (still or sparkling).
- Ne vzemite z mineralno vodo (z mehurčki ali brez).
In addition, BMD at the femoral neck and total body was maintained.
Poleg tega se je MGK vratu stegnenice in celotnega telesa vzdrževala.
The tablets are supplied in triplex blister (PVC/PE/PVDC/AL) packs containing 14, 28, 56, 98, 112 and 50 x 1 (unit dose).
Tablete so na voljo v pakiranjih s tremi pretisnimi omoti (PVC/PE/PVDC/AL), ki vsebujejo po 14, 28, 56, 98, 112 in 50 x 1 (enkratni odmerek) tablet.
In the two-year extensions of these studies the BMD in the spine and trochanter continued to increase.
V dvoletnem podaljšku teh študij se je MGK hrbtenice in trohantra še naprej zviševala.
No specific interaction studies have been carried out, but alendronate was used in clinical trials concomitantly with a number of other commonly prescribed medicines without any evidence of clinically unfavourable interactions.
Specifičnih študij interakcije niso izvedli, vendar pa so Alendronat HEXAL uporabljali v kliničnih preskušanjih sočasno s številnimi drugimi pogosto predpisanimi zdravili, pri čemer niso ugotovili nobenih kliničnih neželenih interakcij.
Studies in which rats were given high doses showed an increased incidence of incomplete foetal bone formation.
Študije, v katerih so podganam dajali visoke odmerke, so pokazale večjo pojavnost nepopolne tvorbe kosti pri plodu.
In postmarketing experience, these symptoms have rarely been seen and/or incapacitating (see section 4.8).
Po izdaji zdravila v promet so te učinke redko opazili in/ali so bili redko moteči (glejte poglavje 4.8).
For other populations, see summary of product characteristics for preparations that contain 5 mg alendronate.
Za druge skupine bolnikov glejte povzetek glavnih značilnosti zdravila za pripravke, ki vsebujejo 5 mg alendronske kisline.
If you take more Alendronate HEXAL than you should If you take too many tablets by mistake, drink a full glass of milk and contact your doctor immediately.
Če ste vzeli večji odmerek zdravila Alendronat HEXAL, kot bi smeli Če pomotoma vzamete preveč tablet, popijte poln kozarec mleka in nemudoma pokličite zdravnika.
Although no clinical information is available, it is likely that, as in animals, elimination of alendronate via the kidney will be reduced in patients with impaired renal function.
Čeprav kliničnih informacij ni na voljo, je možno, da se, tako kot pri živalih, izločanje alendronske kisline preko ledvic zmanjša pri bolnikih z motnjami v delovanju ledvic.
While on treatment, these patients should avoid invasive dental procedures if possible.
Ti bolniki bi se morali v času zdravljenja po možnosti izogibati invazivnim zobozdravstvenim posegom.
In addition, a statistically significant reduction in the incidence of hip fractures was confirmed (1.1 % versus 2.2 %, a reduction of 51 %).
Poleg tega je bilo potrjeno statistično pomembno zmanjšanje pojavnosti zlomov kolka (1,1% v primerjavi z 2,2%, zmanjšanje za
Broken bones can happen during normal, everyday activity, such as lifting, or from minor injury that would not generally break normal bone.
Do zlomov kosti lahko pride že med običajno vsakodnevno aktivnostjo, kot je dvigovanje, ali pri manjši poškodbi, ki običajno ne bi povzročila zloma normalne kosti.
Many of these patients were also receiving chemotherapy and corticosteroids.
Veliko število teh bolnikov je prejemalo tudi kemoterapijo in kortikosteroide.
On account of the risk of oesophageal irritation, vomiting should not be induced and the patient should be kept in an upright position.
Zaradi tveganja za draženje požiralnika se bruhanja ne sme izzvati, bolnik pa mora ostati v zravnanem položaju.
• FIT 2: A four-year study with 4432 patients who had a low bone mass but had not had any vertebral fracture at the start of the study.
• FIT 2: Štiriletna študija na 4432 bolnicah z nizko kostno maso, vendar na začetku študije brez zloma vretenca.
The following terms are used to describe how often side effects have been reported.
Pri opisu, kako pogosto so poročali o neželenih učinkih, se uporabljajo naslednji izrazi.
Do not take two tablets on the same day.
Ne vzemite dveh tablet na isti dan. Nadaljujte z jemanjem ene tablete na dan.
Biotransformation There is no evidence that alendronate is metabolised in animals or humans.
Biotransformacija Ni dokazov, da se alendronska kislina presnavlja pri živalih ali ljudeh.
The Applicant submitted an extensive review of the literature concerning the treatment of osteoporosis in men.
Vlagatelj je predložil obširen pregled literature na temo zdravljenja osteoporoze pri moških.
However, the incidence of reductions in serum calcium to <2.0 mmol/l and serum phosphate to ≤0.65 mmol/l was comparable in the two groups.
Vendar pa je bila pojavnost znižanja serumskega kalcija na < 2,0 mmol/l in serumskega fosfata na ≤ 0,65 mmol/l v obeh skupinah primerljiva.
Please read the package leaflet before use.
Pred uporabo preberite priloženo navodilo.
Alendronate belongs to a group of non-hormonal medicines called bisphosphonates.
Alendronat HEXAL spada v skupino nehormonskih zdravil, ki jih imenujemo difosfonati.
OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF ALENDRONATE HEXAL AND ASSOCIATED NAMES (see Annex I)
SPLOŠNI POVZETEK ZNANSTVENEGA VREDNOTENJA ZDRAVILA ALENDRONATE HEXAL IN Z NJIM POVEZANIH IMEN (glejte Dodatek I)
2) Do not chew the tablet or allow it to dissolve in your mouth.
2) Tablete ne žvečite in ne raztapljajte v ustih.
Very rare (≤1/10,000): Isolated cases of severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported.
Zelo redki (≤1/10.000): poročali so o posameznih primerih hudih kožnih reakcij, vključno s StevensJohnsonovim sindromom in toksično epidermalno nekrolizo.
The terminal half-life in humans is estimated to exceed ten years, reflecting release of alendronate from the skeleton.
Ocenjujejo, da je končni razpolovni čas pri ljudeh daljši od desetih let, kar odraža sproščanje alendronske kisline iz kosti.
Following a single intravenous dose of 10 mg, the renal clearance of alendronate was 71 ml/min, and systemic clearance did not exceed 200 ml/min.
Po enkratnem intravenskem odmerku 10 mg je bil ledvični očistek alendronske kisline 71 ml/min, sistemski očistek pa ni presegel 200 ml/min.
It is very important to follow instructions 1), 2), 3) and 4) to help the Alendronate HEXAL reach your stomach quickly and help reduce the chance of irritating your gullet (oesophagusthe tube that connects your mouth with your stomach).
Zelo pomembno je, da upoštevate navodila 1), 2), 3) in 4), da bo lahko Alendronat HEXAL hitro prišel v želodec in da boste zmanjšali možnost draženja požiralnika (cevi, ki povezuje usta z želodcem).
Osteonecrosis of the jaw is generally associated with tooth extraction and/or local infection (including osteomyelistis).
Osteonekroza čeljusti se običajno povezuje s puljenjem zoba in/ali lokalno okužbo (vključno z osteomielitisom).
For post-menopausal women who are not receiving oestrogen treatment the recommended dose is one 10 mg tablet daily.
Za ženske po menopavzi, ki ne prejemajo zdravljenja z estrogeni, je priporočen odmerek ena 10 mg tableta dnevno.
Alendronate 10 mg and 5 mg were effective irrespective of the dose or duration of steroid use.
Alendronat HEXAL 10 mg in 5 mg sta bila učinkovita ne glede na odmerek ali trajanje jemanja steroidov.
The recommended dosage is 10 mg once daily.
Priporočen odmerek je 10 mg enkrat dnevno.
Pharmacotherapeutic group: Drugs for treatment of bone diseases, bisphosphonates.
Farmakoterapevtska skupina: zdravila za zdravljenje bolezni kosti, difosfonati.
The effects of alendronate on BMD and fracture incidence in post-menopausal women were studied in two initial efficacy studies of identical design (n=994), and in the Fracture Intervention Trial (FIT: n=6459).
Učinke Alendronata HEXAL na MGK in pojavnost zlomov pri ženskah po menopavzi so raziskovali v dveh začetnih enako zasnovanih študijah učinkovitosti (n=994) in v preskušanju FIT (Fracture Intervention Trial, n=6459).
As well as your treatment with Alendronate HEXAL, your doctor may suggest you make changes to your lifestyle to help your condition, such as:
Poleg zdravljenja z zdravilom Alendronat HEXAL vam lahko zdravnik predlaga spremembe v načinu življenja, ki pomagajo pri vaši bolezni.
No other clinically significant active substance interactions are expected.
Drugih klinično pomembnih interakcij zdravilne učinkovine ni pričakovati.
If you are being treated by a dentist or if you are going to have dental surgery, tell your dentist that you are taking Alendronate HEXAL.
Če se zdravite pri zobozdravniku ali boste imeli kirurški poseg na zobeh, povejte svojemu zobozdravniku, da jemljete zdravilo Alendronat HEXAL.
Do not take the tablets after the expiry date stated on the blister and the carton.
Tablet ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na pretisnem omotu in na škatli.
Excipient: 103.95 mg lactose monohydrate per tablet For a full list of excipients see section 6.1.
Pomožna snov: 103,95 mg laktoze monohidrata na tableto Za celoten seznam pomožnih snovi glejte poglavje 6.1.
It is very important that complete administration instructions are given to, and understood, by the patient (see section 4.2).
Zelo pomembno je, da se bolnika v celoti pouči o uporabi zdravila in da navodila tudi razume (glejte poglavje 4.2).
Eating a balanced diet Your doctor can advise you about your diet or whether you should take any dietary supplements.
Uravnotežena prehrana Zdravnik vam lahko svetuje glede prehrane ali morebitnih prehranskih dodatkov.
Bone formed during treatment with alendronate is of normal quality.
Kost, ki se tvori med zdravljenjem z Alendronatom HEXAL, je normalne kakovosti.
Bioavailability was negligible irrespective of whether alendronate was given together with or up to two hours after a standardised breakfast.
Biološka uporabnost je bila zanemarljiva ne glede na to, ali je bil Alendronat HEXAL vzet skupaj s standardiziranim zajtrkom ali do dve uri po njem.
If left untreated, however, it can result in broken bones.
Če se ne zdravi, lahko povzroči zlome kosti.
In the patients who received alendronate in doses up to 10 mg daily and in whom biopsy was performed after one year no signs of a disturbance of the bone mineralisation process were seen.
Pri bolnikih, ki so prejemali Alendronat HEXAL v odmerkih do 10 mg dnevno in pri katerih je bila po enem letu opravljena biopsija, niso opazili znakov motenj v procesu mineralizacije kosti.
Alendronate prevents the loss of bone, and helps to rebuild bone.
Alendronat HEXAL preprečuje izgubo kostne mase in pomaga pri ponovni gradnji kosti.
Three-year studies Alendronate10 mg daily (n=196)
Triletne študije Alendronat HEXAL 10 mg dnevno (n=196)
Most patients had relief of symptoms after stopping treatment.
Večina bolnikov je po prenehanju zdravljenja občutila olajšanje simptomov.
ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM, STRENGTH OF THE MEDICINAL PRODUCT, ROUTE OF ADMINISTRATION, APPLICANT, MARKETING AUTHORISATION HOLDER IN THE MEMBER STATES
DODATEK I SEZNAM IMEN, FARMACEVTSKIH OBLIK, JAKOSTI ZDRAVILA, POTI UPORABE ZDRAVILA, PREDLAGATELJEV, IMETNIKOV DOVOLJENJA ZA PROMET Z ZDRAVILOM V DRŽAVAH ČLANICAH
Despite no increased risk having been observed in extensive clinical trials, following marketing of the original preparation there have been reports of rare cases of gastric and duodenal ulcers, some of them severe and with complications.
Kljub temu, da v obsežnih kliničnih preskušanjih niso opazili povečanega tveganja, so po izdaji originatorjevega zdravila v promet poročali o redkih primerih razjed na želodcu in dvanajstniku, od katerih so bili nekateri hudi in s komplikacijami.
Concomitant administration of alendronate with coffee or orange juice reduced bioavailability by approx. 60 %.
Sočasna uporaba Alendronata HEXAL s kavo ali pomarančnim sokom je zmanjšala biološko uporabnost za približno 60%.
Driving and using machines Alendronate HEXAL should not affect your ability to drive or operate machines.
Vpliv na sposobnost upravljanja vozil in strojev Alendronat HEXAL ne bi smel vplivati na vašo sposobnost vožnje ali upravljanja strojev.
However, in rare cases, symptomatic hypocalcaemia has been reported which occasionally has been severe and often occurred in patients with predisposing conditions (e.g. hypoparathyroidism, vitamin D deficiency and in cases of calcium malabsorption).
Vendar pa obstajajo redka poročila o simptomatski hipokalcemiji, ki je bila občasno huda in se je pogosto pojavila pri bolnikih s predispozicijami (npr. hipoparatiroidizem, pomanjkanje vitamina D in v primerih malabsorpcije kalcija).
Animal studies revealed effects on foetal bone formation at high doses.
Študije na živalih so pokazale učinke na tvorbo kosti pri plodu pri visokih odmerkih.
Other drinks (including mineral water), food and some medicines are likely to reduce the absorption of alendronate (see section 4.5).
Druge pijače (vključno z mineralno vodo), hrana in nekatera zdravila lahko zmanjšajo absorpcijo Alendronata HEXAL (glejte poglavje 4.5).
It is not known whether alendronate is excreted into breast milk in humans.
Ni znano, ali se pri ljudeh alendronska kislina izloča v materino mleko.
Hypocalcaemia must be corrected before treatment with alendronate is initiated (see section 4.3).
Hipokalcemijo je treba korigirati pred začetkom zdravljenja z Alendronatom HEXAL (glejte poglavje 4.3).
Smoking appears to increase the rate at which you lose bone and, therefore, may increase your risk of broken bones.
Prenehanje kajenja Kaže, da kajenje povečuje hitrost izgubljanja kostne mase in lahko zato zveča tveganje za zlome kosti.
No undesirable effects could be related to the combination treatment.
S kombiniranim zdravljenjem ni bilo mogoče povezati nobenih neželenih učinkov.
• Patients should not lie down until after the first meal of the day, which must be at least 30 minutes after taking the tablet.
• Bolnik ne sme leči, dokler ne zaužije prvega dnevnega obroka, kar pa ne sme biti prej kot 30 minut po zaužitju tablete.
Adverse reactions reported by the investigators as possibly, probably or definitely related to the active substance are presented below if they occurred in ≥ 1 % of any in the treatment groups in the one-year study or in ≥ 1 % of the patients who were treated with alendronate 10 mg per day and with an incidence higher than in patients who were treated with placebo in three-year studies.
Neželene reakcije, o katerih so raziskovalci poročali, da so morda, verjetno ali zagotovo povezane z zdravilno učinkovino, so predstavljene spodaj, če so se pojavile pri ≥1% v katerikoli od skupin zdravljenja v enoletni študiji ali pri ≥1% bolnikov, ki so se zdravili z Alendronatom HEXAL 10 mg dnevno in pri katerih je bila pogostnost višja kot pri bolnikih, zdravljenih s placebom v triletnih študijah.
Therefore no adjustment of the dose is necessary for elderly patients.
Zato pri starejših prilagajanje odmerka ni potrebno.
MINIMUM PARTICULARS TO APPEAR ON BLISTERS PVC/PE/PVDC/AL
PODATKI, KI MORAJO BITI NAJMANJ NAVEDENI NA PRETISNEM OMOTU PVC/PE/PVDC/AL
A subset had recurrence of symptoms when rechallenged with the same medicinal product or another bisphosphonate.
Pri podskupini bolnikov so se simptomi ponovili, ko so ponovno prejeli enako zdravilo ali drug difosfonat.
1) After getting up for the day and before taking any food, drink, or other medicine, swallow your Alendronate HEXAL with a full glass of water only (not mineral water) (not less than 200 ml or 7 fl. oz.).
1) Ko zjutraj vstanete in še preden zaužijete kakršnokoli hrano, pijačo ali drugo zdravilo, pogoltnite tableto Alendronat HEXAL izključno s polnim kozarcem vode (ne mineralne vode) (ne manj kot 200 ml).
Transient symptoms as in an acute phase reaction (myalgia, malaise and in rare cases fever) usually in connection with the start of treatment.
Prehodni simptomi kot pri reakciji v akutni fazi (mialgija, slabo počutje in v redkih primerih zvišana telesna temperatura), običajno povezani z začetkom zdravljenja.
An effect on nonvertebral fractures has nonetheless not been demonstrated in this population.
Učinek zdravila na nevertebralne zlome pa v tej populaciji kljub vsemu ni bil dokazan.
Clinical judgement of the treating physician should guide the management plan of each patient based on individual benefit/risk assessment.
Lečeči zdravnik bi moral po klinični presoji na podlagi razmerja med koristjo in tveganjem načrtovati obravnavo vsakega bolnika.
• FIT 1: A three-year study with 2027 patients who had had at least one baseline vertebral (compression) fracture.
• FIT 1: Triletna študija na 2027 bolnicah, ki so imele na začetku študije vsaj en (kompresijski) zlom vretenca.
A reduction in the incidence of vertebral, but not of non-vertebral fractures has been demonstrated.”
Dokazano je bilo zmanjšanje pojavnosti vertebralnih zlomov, ne pa tudi nevertebralnih zlomov."
• Oesophageal abnormalities and other factors that delay oesophageal emptying, such as stricture or achalasia.
• Nenormalnosti požiralnika in drugi dejavniki, ki upočasnjujejo praznjenje požiralnika, kot sta zožitev ali ahalazija.
The applicant was asked to further justify the broad indication “treatment of osteoporosis in men” for Alendronate HEXAL.
Vlagatelj je bil zaprošen, da podrobneje utemelji široko zastavljeno indikacijo "zdravljenje osteoporoze pri moških" z zdravilom Alendronate HEXAL.
In a retrospective analysis (assessed by quantitative radiography) one new fracture (0.8 %) was documented among patients treated with alendronate, compared with 6 new fractures (7.1 %) for placebo (p=0.017).
Z retrospektivno analizo (ocenjeno s kvantitativno radiografijo) je bil dokumentiran en nov zlom (0,8%) med bolniki, ki so se zdravili z Alendronatom HEXAL, v primerjavi s 6 novimi zlomi (7,1%) pri placebu (p=0,017).
WHAT IS ALENDRONATE HEXAL AND WHAT IT IS USED FOR
KAJ JE ZDRAVILO ALENDRONAT HEXAL IN ZA KAJ GA UPORABLJAMO
Alendronate has no influence on the ability to drive and use machines.
Alendronat HEXAL nima vpliva na sposobnost vožnje in upravljanja s stroji.
Alendronate is not excreted through the acidic or basic transport systems of the kidney in rats, and thus it is not thought to interfere with the excretion of other active substances by those systems in humans.
Alendronska kislina se pri podganah ne izloča prek acidobaznega transportnega sistema ledvic in naj zato pri ljudeh ne bi ovirala izločanja drugih zdravilnih učinkovin prek teh sistemov.
Preclinical studies show that the active substance that is not deposited in bone is rapidly excreted in the urine.
Predklinične študije kažejo, da se zdravilna učinkovina, ki se ne nalaga v kosteh, hitro izloča z urinom.
For patients requiring dental procedures, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of osteonecrosis of the jaw.
Za bolnike, ki potrebujejo posege na zobeh, ni na voljo podatkov o tem, ali prenehanje zdravljenja z difosfonati zmanjša tveganje za osteonekrozo čeljusti.
Two studies from Orwell and Ringe demonstrated that compared respectively with placebo or alfacalcidol, alendronate treatment reduced the incidence of vertebral fractures in men with osteoporosis.
Dve raziskavi, ki sta jih izvedla Orwell in Ringe, sta pokazali, da zdravljenje z alendronatom v primerjavi s placebom ali alfakalcidolom zniža pojavnost vertebralnih zlomov pri moških z osteoporozo.
On account of the positive effects of alendronate on the increase in bone mineralisation, reductions in serum calcium and serum phosphate may occur.
Ker ima Alendronat HEXAL pozitivne učinke na povečanje vsebnosti mineralov v kosteh, se lahko pojavijo znižanja serumskega kalcija in fosfata.
Following a single intravenous dose of (14C) alendronate, approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the faeces.
Po enkratnem intravenskem odmerku (14C) Alendronata HEXAL se je približno 50% radioaktivnosti izločilo z urinom v 72 urah in v blatu so odkrili malo ali nič radioaktivnosti.
Alendronate HEXAL can treat your osteoporosis only if you continue to take the tablets.
Alendronat HEXAL lahko zdravi osteoporozo le, če redno jemljete tablete.
7) It is important that you continue taking Alendronate HEXAL for as long as your doctor prescribes the medicine.
7) Pomembno, je, da zdravilo Alendronat HEXAL jemljete tako dolgo, kot vam je predpisal zdravnik.
Osteoporosis in men: The recommended dosage is 10 mg once daily.
Osteoporoza pri moških: Priporočen odmerek je 10 mg enkrat dnevno.
Osteoporosis in men with increased risk of fracture The efficacy of alendronate 10 mg once daily in men (31-87 years, mean age 63 years, n=241) with osteoporosis was evaluated in a two-year study.
Osteoporoza pri moških s povečanim tveganjem za zlom Učinkovitost Alendronata HEXAL 10 mg enkrat dnevno pri moških (starih 31-87 let, povprečna starost 63 let, n=241) z osteoporozo so ocenjevali v dvoletni študiji.
Broken bones usually occur at the hip, spine, or wrist and can lead not only to pain but also to considerable problems like stooped posture (‘dowager's hump') and loss of mobility.
Največkrat se zlomijo kosti kolka, hrbtenice ali zapestja, ki ne povzročajo samo bolečin, temveč tudi precejšnje težave, kot so sključena drža (grba) in nezmožnost gibanja.
Your doctor has prescribed Alendronate HEXAL to treat your osteoporosis.
Zdravnik vam je predpisal Alendronat HEXAL za zdravljenje osteoporoze.
In healthy persons, oral prednisolone (20 mg three times daily for five days) did not result in any clinically meaningful change in the oral bioavailability of alendronate (a mean increase ranging from 20 % to 44 %).
Pri zdravih osebah peroralno jemanje prednizolona (20 mg trikrat dnevno pet dni) ni povzročilo nobene klinično pomembne spremembe biološke uporabnosti Alendronata HEXAL (srednje zvišanje se je gibalo od 20% do