natgillin/translations-raw huggingface dataset:
The safety and efficacy of daptomycin was evaluated in paediatric patients aged 1 to 17 years (Study DAP-PEDBAC-11-02) with bacteraemia caused by Staphylococcus aureus.
Varnost in učinkovitost daptomicina so ocenili pri pediatričnih bolnikih, starih od 1 do 17 let (študija DAP-PEDBAC-11-02) z bakteriemijo zaradi bakterije Staphylococcus aureus.
AUC0-∞ daptomycin was significantly increased (mean 42% higher) compared with non-obese matched controls.
70 ml/min je bila vrednost AUC0-∞ daptomicina znatno višja (v povprečju za 42 % višja) v primerjavi s primerljivimi kontrolnimi preskušanci z normalno telesno maso.
The pharmacokinetics of daptomycin is not altered in subjects with moderate hepatic impairment (Child-Pugh B classification of hepatic impairment) compared with healthy volunteers matched for gender, age and weight following a single 4 mg/kg dose.
Po dajanju enkratnih odmerkov 4 mg/kg se farmakokinetika daptomicina pri preskušancih z zmerno okvaro jeter (razred B po razvrstitvi okvare jeter po lestvici Child-Pugh) ni spremenila v primerjavi z zdravimi prostovoljci, primerljivimi glede na spol, starost in telesno maso.
- Known or suspected RIE due to Staphylococcus aureus: daptomycin 6mg/kg is administered once every 24 hours.
- Dokazan RIE zaradi Staphylococcus aureus ali sum nanj: daptomicin dajemo v odmerku 6 mg/kg vsakih 24 ur.
The Marketing Authorisation Holder shall ensure that all laboratories expected to perform Daptomycin Hospira susceptibility testing are provided with: - Summary of Product Characteristics - Laboratory susceptibility testing leaflet
Imetnik dovoljenja za promet z zdravilom mora zagotoviti, da bodo vsi laboratoriji, ki bodo predvidoma izvajali testiranja občutljivosti, prejeli: - povzetek glavnih značilnosti zdravila, - letak za laboratorije s pojasnili glede testiranja na občutljivost.
These limitations of the patients population treated should be taken into account when deciding to use daptomycin.
Pri odločanju o uporabi daptomicina je treba upoštevati navedene omejitve pri zdravljeni skupini bolnikov.
For the 30-minute intravenous infusion, the combined storage time (reconstituted solution in vial and diluted solution in infusion bag; see section 6.6) at 25°C must not exceed 12 hours (or 24 at 2°C-8°C).
Pri 30-minutni intravenski infuziji skupni čas shranjevanja (rekonstituirana raztopina v viali in razredčena raztopina v infuzijski vrečki: glejte poglavje 6.6) pri 25 °C ne sme presegati 12 ur (ali 24 ur pri 2 °C - 8 °C).
Frequency not known: frequency cannot be estimated from the available data Antibacterial-associated colitis, including pseudomembranous colitis (severe or persistent diarrhoea containing blood and/or mucus, associated with abdominal pain or fever), easy bruising, bleeding gums, or nosebleeds.
Neznana pogostnost: pogostnosti iz razpoložljivih podatkov ni mogoče oceniti Z antibiotiki povezan kolitis, vključno s psevdomembranskim kolitisom (huda ali trdovratna driska, ki vsebuje kri in/ali sluz, povezana z bolečinami v trebuhu in zvišano telesno temperaturo), hiter pojav modric, krvaveče dlesni ali krvavitve iz nosu.
A total of 81 subjects were treated in the study, including 55 subjects who received daptomycin and 26 subjects who received standard-of-care.
V študiji je bilo zdravljenih skupno 81 bolnikov, od katerih jih je 55 prejemalo daptomicin in
After a single 4, 8, or 10 mg/kg dose of daptomycin, total clearance and elimination half-life of daptomycin in children 2-6 years of age were similar at different doses; total clearance was higher and elimination half-life was shorter than in adolescents.
Po enkratnem odmerku 4, 8 ali 10 mg/kg daptomicina sta bila celotni očistek in eliminacijski razpolovni čas daptomicina pri otrocih v starosti od 2 do 6 let ob različnih odmerkih podobna; celotni očistek je bil večji, eliminacijski razpolovni čas pa krajši kot pri mladostnikih.
Hold the vial by the vial neck, tilt the vial and swirl vial contents until the product is completely reconstituted.
Vialo držite za vrat, nato jo nagnite in vrtite njeno vsebino, dokler zdravilo ni popolnoma rekonstituirano.
Read the package leaflet before use.
intravenska uporaba Pred uporabo preberite priloženo navodilo!
- Adult and paediatric (1 to 17 years of age) patients withStaphylococcus aureus bacteraemia (SAB).
- pri odraslih in pediatričnih bolnikih (starih od 1 do 17 let) z bakteriemijo Staphylococcus aureus (SAB).
Not known*: Eosinophilic pneumonia 1**, cough
eozinofilna pljučnica 1**, kašelj
Daptomycin Hospira is therefore not indicated for the treatment of pneumonia.
Daptomicin zato ni indiciran za zdravljenje pljučnice.
Limb pain, serum creatine phosphokinase (CPK) increased
bolečine v okončinah, zvišane vrednosti kreatin-fosfokinaze (CPK) v serumu občasni:
Not known*: Acute generalised exanthematous pustulosis
akutna generalizirana eksantematozna pustuloza
The reconstituted solution should then be injected intravenously slowly over 2 minutes as directed in section 4.2.
Rekonstituirano raztopino morate nato 2 minuti počasi intravensko injicirati, kot je navedeno v poglavju 4.2.
Uncommon: Paraesthesia, taste disorder, tremor, eye irritation Not known*: Peripheral neuropathy**
parestezija, motnje okušanja, tremor, draženje očesa neznana pogostnost*:
Streptococcus dysgalactiae subsp equisimilis*
Streptococcus dysgalactiae, subsp.
Daptomycin is administered intravenously in 0.9% sodium chloride (see section 6.6).
Daptomicin dajemo intravensko v 0,9-odstotni raztopini natrijevega klorida (glejte poglavje 6.6).
RIE due to Staphylococcus aureus
RIE zaradi bakterije Staphylococcus aureus
- cSSTI with concurrent SAB: daptomycin 6 mg/kg is administered once every 24 hours.
- cSSTI s sočasno SAB: daptomicin dajemo v odmerku 6 mg/kg vsakih 24 ur.
Relative to non-obese subjects daptomycin systemic exposure measured by AUC was about 28% higher in moderately obese subjects (Body Mass Index of 25-40 kg/m2) and 42% higher in extremely obese subjects
V primerjavi s preskušanci z normalno telesno maso je bila sistemska izpostavljenost daptomicinu, izmerjena kot vrednost AUC, za približno 28 % večja pri zmerno debelih preskušancih (indeks telesne mase 25-40 kg/m2) in za 42 % večja pri zelo debelih preskušancih (indeks telesne mase > 40 kg/m Vendar pa velja, da zgolj na osnovi debelosti prilagajanje odmerka ni potrebno.
It is mixed with a solvent to form a liquid before it is administered.
Pred uporabo ga je treba zmešati z vehiklom, da nastane tekočina.
Plasma exposures achieved with these doses were consistent with those achieved in the adult cSSTI study (following 4 mg/kg once daily in adults).
Izpostavljenost v plazmi, dosežena s temi odmerki, je bila skladna z izpostavljenostjo, doseženo v študiji zapletenih okužb kože in mehkih tkiv pri odraslih (po odmerku 4 mg/kg enkrat na dan pri odraslih).
Other medicines and Daptomycin Hospira Tell your doctor or nurse if you are taking, have recently taken or might take any other medicines.
Obvestite zdravnika ali medicinsko sestro, če jemljete, ste pred kratkim jemali ali pa boste morda začeli jemati katerokoli drugo zdravilo.
Daptomycin undergoes little to no Cytochrome P450 (CYP450)-mediated metabolism.
Preko citokroma P450 (CYP450) se daptomicin presnavlja le malo ali nič.
Clostridium difficile-associated diarrhoea (CDAD) has been reported with daptomycin (see section 4.8).
Diareja, ki jo povzroča bakterija Clostridium difficile Pri uporabi daptomicina so poročali o diareji, ki jo povzroča bakterija Clostridium difficile (CDADClostridium difficile-associated diarrhoea) (glejte poglavje 4.8).
An adjustment of daptomycin dose interval is needed for adult patients whose creatinine clearance is <30 ml/min (see sections 4.2 and 5.2).
Pri odraslih bolnikih z očistkom kreatinina < 30 ml/min je treba prilagoditi interval odmerjanja daptomicina (glejte poglavji 4.2 in 5.2).
Stability of the diluted solution in infusion bags is established as 12 hours at 25°C or 24 hours if stored under refrigeration at 2°C-8°C.
Razredčena raztopina v infuzijskih vrečkah je stabilna 12 ur pri 25 °C ali 24 ur v primeru shranjevanja v hladilniku pri 2 °C - 8 °C.
After a single 6 mg/kg dose of daptomycin, the clearance and elimination half-life of daptomycin in children 13-24 months of age were similar to children 2-6 years of age who received a single 4-10 mg/kg dose.
Po enkratnem odmerku 6 mg/kg daptomicina sta bila celotni očistek in eliminacijski razpolovni čas daptomicina pri otrocih, starih od 13 do 24 mesecev, podobna kot pri otrocih, starih od 2 do 6 let, ki so prejeli enkraten odmerek 410 mg/kg.
In adults, daptomycin may be administered intravenously as an infusion over 30 minutes or as an injection over 2 minutes.
Pri odraslih je daptomicin mogoče aplicirati intravensko v obliki infuzije, ki traja 30 minut, ali v obliki injekcije, ki traja 2 minuti.
The duration of therapy may need to be longer than 14 days in accordance with the perceived risk of complications in the individual patient.
Glede na pričakovano tveganje za zaplete pri posameznem bolniku je lahko trajanje zdravljenja daljše od 14 dni.
Not known*: Hypersensitivity**, manifested by isolated spontaneous reports including, but not limited to angioedema, drug rash with eosinophilia and systemic symptoms (DRESS), pulmonary eosinophilia, vesicobullous rash with mucous membrane involvement and sensation of oropharyngeal swelling, anaphylaxis**, infusion reactions including the following symptoms: tachycardia, wheezing, pyrexia, rigors, systemic flushing, vertigo, syncope and metallic taste
preobčutljivost**, razvidna iz posameznih spontanih poročil, vključno z, a ne omejeno na angioedem, z zdravilom povezani izpuščaj z eozinofilijo in sistemskimi simptomi (DRESS), pljučna eozinofilija, vezikulobulozni izpuščaj s prizadetostjo sluznic in občutek otekanja ust in žrela, anafilaksija**, infuzijske reakcije, ki vključujejo naslednje simptome: tahikardijo, piskajoče dihanje, pireksijo, okorelost, pordevanje po celem telesu, vrtoglavico, sinkopo in kovinski okus v ustih
12 mg/kg once every
12 mg/kg vsakih
Based on these study results, both methods of daptomycin administration, the 2-minute intravenous injection and the 30-minute intravenous infusion,
Glede na rezultate teh študij imata oba načina dajanja daptomicina, tako 2-minutna intravenska injekcija kot 30-minutna intravenska infuzija, podoben profil varnosti in prenašanja.
The response to treatment, renal function and creatine phosphokinase (CPK) levels should be closely monitored in all patients with any degree of renal impairment (see sections 4.4 and 5.2).
Pri vseh bolnikih z okvaro ledvic katerekoli stopnje je treba natančno spremljati odziv na zdravljenje, delovanje ledvic in ravni kreatin-fosfokinaze (CPK - Creatine Phosphokinase) (glejte poglavji 4.4 in 5.2).
a 2-6 years (N=7)
2-6 let (N = 7)
In paediatric patients aged 7 to 17 years, Daptomycin Hospira is given by intravenous infusion over a 30-minute period (see section 6.6).
Pri pediatričnih bolnikih (starih od 7 do 17 let) se zdravilo Daptomycin Hospira daje v obliki intravenske infuzije s časom infundiranja 30 minut (glejte poglavje 6.6).
Invert the vial in order to allow the solution to drain towards the stopper.
Obrnite vialo tako, da raztopina lahko steče proti zamašku.
If CDAD is suspected or confirmed, daptomycin may need to be discontinued and appropriate treatment instituted as clinically indicated.
Če obstaja sum na CDAD ali so njeno diagnozo potrdili, je v skladu s klinično indikacijo morda treba prekiniti uporabo daptomicina in uvesti ustrezno zdravljenje.
In paediatric patients aged 1 to 6 years, Daptomycin Hospira is given by intravenous infusion over a 60-minute period (see section 6.6).
Pri pediatričnih bolnikih (starih od 1 do 6 let) se zdravilo Daptomycin Hospira daje v obliki intravenske infuzije s časom infundiranja 60 minut (glejte poglavje 6.6).
The efficacy of daptomycin in patients with prosthetic valve infections or with left-sided infective endocarditis due to Staphylococcus aureus has not been demonstrated.
Pri bolnikih z okužbo umetne zaklopke ali levostranskim infekcijskim endokarditisom zaradi bakterije Staphylococcus aureus učinkovitosti daptomicina niso dokazali.
The reconstituted and diluted solution should then be infused intravenously over 30 or 60 minutes.
Rekonstituirano in razredčeno raztopino morate nato intravensko infundirati 30 ali 60 minut.
Paediatric patients (1 to 17 years of age) The recommended dosage regimens for paediatric patients based on age and indication are shown below.
Spodaj so navedeni priporočeni režimi odmerjanja za pediatrične bolnike glede na starost in indikacijo.
The active substance in Daptomycin Hospira powder for solution for injection/infusion is daptomycin.
Učinkovina v zdravilu Daptomicin Hospira prašek za raztopino za injiciranje/infundiranje je daptomicin.
Eosinophilic pneumonia has been reported in patients receiving daptomycin (see section 4.8).
Pri bolnikih, ki so prejemali daptomicin, so poročali o eozinofilni pljučnici (glejte poglavje 4.8).
- CPK should be measured more frequently (e.g. every 2-3 days at least during the first two weeks of treatment) in patients who are at higher risk of developing myopathy.
• Pri bolnikih, pri katerih obstaja večje tveganje za nastanek miopatij, je treba CPK meriti pogosteje (na primer vsaka 2-3 dni, vsaj v prvih dveh tednih zdravljenja).
Uncommon: Myositis, increased myoglobin, muscular weakness, muscle pain, arthralgia, serum lactate dehydrogenase (LDH) increased, muscle cramps
miozitis, zvišane vrednosti mioglobina, mišična oslabelost, bolečine v mišicah, artralgija, zvišane vrednosti laktatdehidrogenaze (LDH) v serumu, mišični krči rabdomioliza neznana pogostnost *:
Available in packs containing 1 vial or 5 vials.
Zdravilo je na voljo v pakiranjih po 1 ali 5 vial.
See below for dose adjustments in patients with renal impairment.
Za prilagajanje odmerkov pri bolnikih z okvaro ledvic glejte spodaj.
After a single 4 mg/kg dose of daptomycin, total clearance of daptomycin in children 7-11 years of age with Gram-positive infection was higher than in adolescents, whereas elimination half-life was shorter.
Po enkratnem odmerku 4 mg/kg daptomicina je bil celotni očistek daptomicina pri otrocih, v starosti od 7 do 11 let, z grampozitivnimi okužbami večji kot pri mladostnikih, eliminacijski razpolovni čas pa je bil krajši.
- New or worsening fever, cough or difficulty breathing.
- zvišana telesna temperatura, kašelj ali težko dihanje oziroma poslabšanje teh simptomov.
In a single human case study, daptomycin was intravenously administered daily for 28 days to a nursing mother at a dose of 500 mg/day, and samples of the patient's breast milk were collected over a 24-hour period on day 27.
V študiji enega samega primera pri ljudeh je doječa mati 28 dni enkrat na dan prejemala daptomicin v intravenskem odmerku 500 mg/dan.
Daptomycin was not mutagenic or clastogenic in a battery of in vivo and in vitro genotoxicity tests.
Daptomicin v seriji preskušanj genotoksičnosti in vivo in in vitro ni bil mutagen ali klastogen.
To prepare Daptomycin Hospira for intravenous injection, please adhere to the following instructions: Aseptic technique should be used throughout to reconstitute lyophilised Daptomycin Hospira.
Pri pripravi zdravila Daptomicin Hospira za intravensko injekcijo upoštevajte naslednja navodila: Za rekonstitucijo liofiliziranega zdravila Daptomicin Hospira morate ves čas uporabljati aseptično tehniko.
Unlike in adults, daptomycin should not be administered by injection over a 2-minute period in paediatric patients.
V nasprotju z odraslimi bolniki se pediatričnim bolnikom daptomicina ne sme dati z 2-minutno injekcijo.
Chemical and physical in-use stability on the reconstituted solution in the vial has been demonstrated for 12 hours at 25°C and up to 48 hours if stored under refrigeration (2°C-8°C).
Kemijsko in fizikalno stabilnost rekonstituirane raztopine v viali med uporabo so dokazali za 12 ur pri 25 °C in do 48 ur v primeru shranjevanja v hladilniku pri (2 °C - 8 °C).
In adults, daptomycin is given by intravenous infusion (see section 6.6) and administered over a 30-minute period or by intravenous injection (see section 6.6) and administered over a 2-minute period.
Pri odraslih daptomicin dajemo v obliki 30-minutne intravenske infuzije (glejte poglavje 6.6) ali v obliki 2-minutne intravenske injekcije (glejte poglavje 6.6).
Gastrointestinal and abdominal pain, nausea, vomiting, constipation, diarrhoea, flatulence, bloating and distension
bolečine v prebavilih in trebuhu, navzea, bruhanje, zaprtje, diareja, flatulenca, napihnjenost trebuha občasni:
Tell your doctor or nurse straight away if you experience any of the following symptoms: - Chest pain or tightness, - Rash with blistering, sometimes affecting the mouth and genitals, - Swelling around throat, - Rapid or weak pulse, - Wheezing, - Fever, - Shivering or trembling, - Hot flushes, - Dizziness, - Fainting, - Metallic taste.
Takoj obvestite zdravnika ali medicinsko sestro, če se vam pojavi katerikoli od naslednjih simptomov: - bolečina ali tiščanje v prsih;, - izpuščaj z mehurčki, ki včasih prizadene usta in spolovila, - otekanje okrog grla, - hiter ali šibek srčni utrip, - piskajoče dihanje, - zvišana telesna temperatura, - drgetanje ali tresenje, - vročinski oblivi, - omotica,
How to store Daptomycin Hospira
Kako uporabljati zdravilo Daptomicin Hospira
Musculoskeletal and connective tissue disorders
Bolezni mišično-skeletnega sistema in vezivnega tkiva pogosti:
To prepare Daptomycin Hospira for intravenous infusion, please adhere to the following instructions: Aseptic technique should be used throughout to reconstitute lyophilised Daptomycin Hospira.
Pri pripravi zdravila Daptomicin Hospira za intravensko infuzijo upoštevajte naslednja navodila: Za rekonstitucijo liofiliziranega zdravila Daptomicin Hospira morate ves čas uporabljati aseptično tehniko.
Serious side effects with frequency not known (frequency cannot be estimated from the available data) A rare but potentially serious lung disorder called eosinophilic pneumonia has been reported in patients given daptomycin, mostly after more than 2 weeks of treatment.
Pri bolnikih, ki so prejemali daptomicin, so poročali o redki, a potencialno resni pljučni bolezni, ki jo imenujemo eozinofilna pljučnica, ki se je večinoma pojavila po več kot 2 tednih zdravljenja.
Plasma exposures achieved with these doses were consistent with those achieved in the adult SAB study (following 6 mg/kg once daily in adults).
Izpostavljenost v plazmi, dosežena s temi odmerki, je bila skladna z izpostavljenostjo, doseženo v študiji bakteriemije z bakterijo Staphylococcus aureus (po odmerku 6 mg/kg enkrat na dan pri odraslih).
Juvenile dogs developed peripheral and spinal nerve lesions at doses lower than those associated with skeletal muscle toxicity.
Pri mladih psih so se pri odmerkih, ki so bili manjši od tistih, povezanih s toksičnostjo za skeletne mišice, pojavile lezije perifernih in spinalnih živcev.
Water should not be used for reconstitution of Daptomycin Hospira for intravenous injection.
Za rekonstitucijo zdravila Daptomicin Hospira za intravensko injiciranje ne smete uporabiti vode.
(2) The same dose adjustments, which are based on PK data in volunteers including PK modelling results, are recommended for adult patients on haemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD).
(2) Za odrasle bolnike na hemodializi (HD) ali kontinuirani ambulantni peritonealni dializi (CAPD) je priporočeno enako prilagajanje odmerka, ki temelji na farmakokinetičnih podatkih prostovoljcev, vključno z rezultati farmakokinetičnega modeliranja.
Uncommon: Thrombocythaemia, eosinophilia, international normalised ratio (INR) increased, leukocytosis
trombocitemija, eozinofilija, povečanje mednarodno umerjenega razmerja (INR), levkocitoza redki:
Using a new syringe, insert the needle into the inverted vial.
Vzemite novo injekcijsko brizgo in vstavite injekcijsko iglo v obrnjeno vialo.
Duration of Therapy
Trajanje zdravljenja
Jaundice
zlatenica
Tell a doctor or a nurse straight away if you experience symptoms suggestive of allergic reaction, such as wheezing, difficulty breathing, swelling of the face, neck and throat, rashes and hives, fever (see section 4 of this leaflet for more information).
Če se pri vas pojavijo simptomi, ki kažejo na alergijsko reakcijo, na primer piskajoče dihanje, težko dihanje, otekanje obraza, vratu in žrela, izpuščaji in koprivnica, zvišana telesna temperatura, takoj obvestite zdravnika ali medicinsko sestro (za več informacij glejte poglavje 4 v tem navodilu za uporabo).
The pharmacokinetics of daptomycin were not significantly altered by aztreonam.
Aztreonam ni bistveno spremenil farmakokinetičnih lastnosti daptomicina.
Transfer the reconstituted solution into a sodium chloride 9 mg/ml (0.9%) infusion bag (typical volume 50 ml).
Rekonstituirano raztopino prenesite v infuzijsko vrečko z 0,9-odstotno (9 mg/ml) raztopino natrijevega klorida (običajni volumen 50 ml).
No clinical data on fertility are available for daptomycin.
Za daptomicin ni na voljo nobenih kliničnih podatkov o vplivu na plodnost.
- The other ingredientsaresodium hydroxideand citric acid.
- Drugi sestavini zdravila sta natrijev hidroksid in citronska kislina.
Although small changes in the pharmacokinetics of daptomycin and tobramycin were observed during coadministration by intravenous infusion over a 30-minute period using a daptomycin dose of 2 mg/kg, the changes were not statistically significant.
Pri sočasnem dajanju daptomicina in tobramicina s 30-minutno intravensko infuzijo, kjer je bil odmerek daptomicina 2 mg/kg so opažali manjše spremembe v farmakokinetiki obeh zdravil, vendar spremembe niso bile statistično značilne.
In all populations the clinical success rates were comparable between the daptomycin and SOC treatment arms, supporting the primary efficacy analysis in the ITT population.
V vseh populacijah je bila stopnja klinične uspešnosti v skupini z daptomicinom približno enaka kot v skupini s standardno oskrbo, kar se je ujemalo z rezultati primarne analize učinkovitosti v populaciji vseh bolnikov, predvidenih za zdravljenje (ITT-intent-to treat).
Daptomycin Hospira is administered intravenously in 0.9 % sodium chloride (see section 6.6).
Zdravilo Daptomycin Hospira se daje v obliki intravenske infuzije v 0,9-odstotni raztopini natrijevega klorida (glejte poglavje 6.6).
After a single 4 mg/kg dose of daptomycin, total clearance normalised by weight and elimination half-life of daptomycin in adolescents (12-17 years of age) with Gram-positive infection were similar to adults.
Po enkratnem odmerku 4 mg/kg daptomicina sta bila celotni očistek, normaliziran glede na telesno maso, in eliminacijski razpolovni čas daptomicina pri mladostnikih (starih od 12 do 17 let) z grampozitivnimi okužbami podobna kot pri odraslih.
However, some cases of marked rises in CPK levels and cases of rhabdomyolysis occurred in adult patients taking one of these medicinal products at the same time as daptomycin.
Vendar pa je pri odraslih bolnikih, ki so jemali eno od teh zdravil sočasno z daptomicinom, v nekaj primerih prišlo do izrazitega zvišanja ravni CPK in primerov rabdomiolize.
Summary of overall therapeutic response by type of baseline pathogen (ME population):
Povzetek skupnih terapevtskih izidov glede na vrsto osnovne okužbe (populacija za mikrobiološko oceno primernih bolnikov):
Failures with daptomycin in the treatment of enterococcal infections that were mostly accompanied by bacteraemia have been reported.
Pri enterokoknih okužbah, ki jih je večinoma spremljala bakteriemija, so poročali o neuspehu zdravljenja z daptomicinom.
Staphylococcus haemolyticus
Staphylococcus haemolyticus koagulazno negativni stafilokoki
350 mg presentation:
Pakiranje po 350 mg:
Therefore, it is recommended that: - Plasma CPK should be measured at baseline and at regular intervals (at least once weekly) during therapy in all patients.
• Pri vseh bolnikih je treba raven CPK v plazmi izmeriti pred začetkom zdravljenja in nato v rednih intervalih (vsaj enkrat tedensko) med zdravljenjem.