natgillin/translations-raw huggingface dataset:
Other information about Nobilis IB Primo QX:
Druge informacije o zdravilu Nobilis IB Primo QX:
What benefit has Nobilis IB Primo QX shown during the studies?
Kakšne koristi je zdravilo Nobilis IB Primo QX izkazalo med študijami?
The withdrawal period for Nobilis IB Primo QX for chickens is zero days.
Karenca za zdravilo Nobilis IB Primo QX pri piščancih je nič dni.
What is the risk associated with Nobilis IB Primo QX?
Kakšna tveganja so povezana z zdravilom Nobilis IB Primo QX?
Why has Nobilis IB Primo QX been approved?
Zakaj je bilo zdravilo Nobilis IB Primo QX odobreno?
How has Nobilis IB Primo QX been studied?
Kako je bilo zdravilo Nobilis IB Primo QX raziskano?
What is Nobilis IB Primo QX?
Kaj je zdravilo Nobilis IB Primo QX?
How does Nobilis IB Primo QX work?
Kako zdravilo Nobilis IB Primo QX deluje?
What is Nobilis IB Primo QX used for?
Za kaj se zdravilo Nobilis IB Primo QX uporablja?
At the request of the European Medicines Agency;
• na zahtevo Evropske agencije za zdravila;
They were considered so inert that testing was not required.
Imeli so jih za tako inertne, da preizkušanje ni bilo potrebno.
In order to avoid all incidents, the following instructions should be absolutely respected.
Da bi se izognili vsem nezgodam, morate dosledno upoštevati naslednja navodila.
Side effects that may be seen but the frequency is not known (frequency cannot be estimated from the available data) are:
Neželeni učinki, ki se lahko pojavijo, vendar njihova pogostnost ni znana (ni je mogoče oceniti iz razpoložljivih podatkov), so:
Currently available data are described in section 5.1 but no recommendation or posology can be made.
Podatke, ki so trenutno na voljo, boste našli v poglavju 5.1, vendar priporočil za odmerjanje ni mogoče dati.
The duration of therapy is variable, but typically less than four days.
Trajanje zdravljenja je različno, vendar je običajno krajše od štirih dni.
Monitoring formation of nitrogen dioxide (NO2)
Nadzor nastajanja dušikovega dioksida (NO2)
The NO2 concentration should be maintained as low as possible and always < 0.5 ppm.
Koncentracija NO2 mora biti čim nižja in vedno <0,5 ppm.
If you see any signs or symptoms that may be associated to bleeding you should directly inform the doctor.
Če vidite kakršnekoli znake ali simptome, ki so morda povezani s krvavitvami, morate o tem obvestiti zdravnika.
Detailed information on this product is available on the website of the European Medicines Agency http://www.ema.europa.eu.
Podrobne informacije o zdravilu so objavljene na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu/.
No signs of any increase adverse effects were noted in this study.
V tej študiji niso opazili nobenih znakov povečanja neželenih učinkov.
Tell your doctor before treatment with INOmax if you are pregnant, think you could be pregnant or are breastfeeding
Pred zdravljenjem z zdravilom INOmax povejte zdravniku, če ste noseči, menite, da bi lahko bili noseči, ali če dojite.
Storage is supervised by the specialists at the hospital.
Shranjevanje nadzoruje strokovnjak v bolnišnici.
Manufacturer Linde France Z.I.
Izdelovalec Linde France Z.I.
Clinical data supporting the suggested dose in the age range 12-17 years is limited.
Klinični podatki, ki podpirajo predlagani odmerek pri mladostnikih, starih od 12 do 17 let, so omejeni.
If the submission of a PSUR and the update of a RMP coincide, they can be submitted at the same time
Če predložitev PSUR in posodobitev RMP sovpadata, se lahko predložita sočasno.
The power supply for the monitoring equipment should be independent of the delivery device function.
Napajanje nadzornih naprav mora biti neodvisno od delovanja naprave za dovajanje.
Effects in non-clinical studies were observed only at exposures considered sufficiently in excess of the maximum human exposure indicating little relevance to clinical use.
Učinke v nekliničnih študijah so opazili samo pri izpostavljenosti, ki je zadostno presegla največjo izpostavljenost pri človeku, kar kaže majhen pomen za klinično uporabo.
The marketing authorisation holder shall submit periodic safety update reports for this product in accordance with the requirements set out in the list of Union reference dates (EURD list) ) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal.
• Redno posodobljena poročila o varnosti zdravila (PSUR) Imetnik dovoljenja za promet z zdravilom mora redno posodobljena poročila o varnosti zdravila za to zdravilo predložiti v skladu z zahtevami, določenimi v seznamu referenčnih datumov Unije (seznamu EURD), opredeljenem v členu 107c(7) Direktive 2001/83/ES in objavljenem na evropskem spletnem portalu o zdravilih.
EFFECTIVE USE OF THE MEDICINAL PRODUCT
UČINKOVITO UPORABO ZDRAVILA
However, therapy with INOmax may last longer.
Vendar lahko zdravljenje z zdravilom INOmax traja dlje.
Among metallic construction materials, only stainless steel can be recommended.
Od kovinskih materialov se priporoča samo nerjaveče jeklo.
There is in general no need for scavenging of excess gas, the work place ambient air quality should however be considered and trace concentrations of NO or NO2/NOx must not exceed set national occupational exposure limits.
Navadno odvečnega plina ni treba odvajati, vendar je treba upoštevati kakovost zraka v delovnem okolju, koncentracije sledov NO ali NO2/NOx pa ne smejo preseči predpisanih nacionalnih omejitev za poklicno izpostavljenost.
Nitric oxide is genotoxic in some test systems.
Dušikov oksid je genotoksičen v nekaterih testnih sistemih.
Elevated NO2 may cause acute lung injury.
Povečanje NO2 lahko povzroči akutne poškodbe pljuč.
Your doctor will take care to check that the blood can carry enough oxygen when you are taking these medicines.
Zdravnik bo preverjal, ali lahko kri prenaša dovolj kisika, kadar jemljete taka zdravila.
Ask your doctor or pharmacist for advice before taking any medicine.
Posvetujte se z zdravnikom ali farmacevtom, preden vzamete katerokoli zdravilo.
No reproduction toxicity studies have been conducted.
Opravili niso nobenih študij toksičnosti za razmnoževanje.
Nitric oxide is a compound produced by many cells of the body.
Dušikov oksid je spojina, ki jo proizvajajo mnoge celice v telesu.
Educational material for Healthcare Professionals
• Izobraževalno gradivo za zdravstvene delavce.
This may increase the right ventricular ejection fraction.
To lahko poveča iztisni delež desnega prekata.
The safety and efficacy of INOmax in premature infants less than 34 weeks of gestation has not yet been established.
Varnost in učinkovitost zdravila INOmax pri nedonošenčkih, rojenih po manj kot 34 tednih nosečnosti, še nista ugotovljeni.
Treatment with INOmax should not be stopped suddenly.
Zdravljenje z zdravilom INOmax se ne sme prekiniti nenadno.
Accidental exposure to INOmax in hospital staff has been associated with adverse events (see section 4.8).
Nenamerna izpostavitev bolnišničnega osebja zdravilu INOmax je bila povezana z neželenimi dogodki (glejte poglavje 4.8).
Bradycardiab (following abrupt discontinuation of therapy)
Srčne bolezni bradikardijab (po nenadni prekinitvi zdravljenja)
The displayed frequency categories use the following convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000), not known (cannot be estimated from the available data).
Kategorije pogostnosti so opredeljene v skladu z naslednjim dogovorom: zelo pogosti (≥ 1/10), pogosti (≥ 1/100 do < 1/10), občasni (≥ 1/1000 do < 1/100), redki (≥ 1/10.000 do < 1/1000), zelo redki (< 1/10.000) in neznana (ni mogoče oceniti iz razpoložljivih podatkov).
If you get any side effects, talk to your doctor or pharmacist or nurse.
Če opazite kateri koli neželeni učinek, se posvetujte z zdravnikom, farmacevtom ali medicinsko sestro.
However, the presence of nitrogen dioxide and moisture creates an aggressive atmosphere.
Vendar prisotnost dušikovega dioksida in vlage tvori agresivno ozračje.
The Marketing Authorisation Holder (MAH) should ensure that, at launch of the new indication, all Healthcare Professionals who are expected to use and/or prescribe INOmax as part of the treatment of peri- or post- operative pulmonary hypertension in adults and children in conjunction to heart surgery are provided with an Educational pack.
Imetnik dovoljenja za promet z zdravilom (MAH) mora zagotoviti, da ob uvedbi nove indikacije vsi zdravstveni delavci, za katere se pričakuje, da bodo uporabljali in/ali predpisovali zdravilo INOmax v okviru zdravljenja pred- ali pooperativne pljučne hipertenzije pri odraslih in otrocih, povezane s srčnim kirurškim posegom, prejmejo izobraževalno gradivo.
A particular attention should be also turned to the fastening of the pressure regulator so as to avoid the risks of accidental failures.
Posebej morate biti pozorni na pritrjevanje regulatorja tlaka, da bi preprečili morebitne okvare.
From a corrosion point of view the supply system can be divided into two zones: 1) From the gas cylinder valve to the humidifier (dry gas) and 2) From the humidifier to outlet (moist gas which may contain NO2).
S stališča rjavenja lahko sistem za dovajanje razdelimo na dva dela: 1) Od ventila jeklenke do vlažilca (suhi plin) in 2) Od vlažilca do izhoda (vlažni plin, ki lahko vsebuje NO2).
The combined used with other vasodilators (e.g. sildenafil) is not extensively studied.
Kombinirane uporabe z drugimi vazodilatatorji (npr. sildenafila) niso preučevali obsežno.
There are also animal data suggesting an increased susceptibility to airway infections upon exposure to low levels of NO2.
Podatki iz raziskav na živalih kažejo tudi povečano dovzetnost za okužbe dihalnih poti pri izpostavljenosti majhnim količinam NO2.
Of the 97 patients treated with INOmax, 2(2 %) were withdrawn from study drug due to methaemoglobin levels >4 %.
Od 97 bolnikov, ki so jih zdravili z zdravilom INOmax, so 2 (2 %) izključili iz študije zaradi koncentracij methemoglobina >4 %.
Follow-up exams at 18-24 months of age were similar between the two groups with respect to mental, motor, audiologic, and neurologic evaluations.
Pregledi pri starosti 18-24 mesecev so pokazali podobnosti v oceni duševnega, motoričnega, avdiološkega in nevrološkega stanja pri obeh skupinah.
The installation of a nitric oxide pipeline system with supply station of gas cylinders, fixed network and terminal units is forbidden.
Namestitev sistema cevi za dušikov oksid iz skladišča za jeklenke, fiksnega omrežja in terminalnih enot je prepovedana.
Immediately prior to each patient initiation, proper procedure must be applied to purge the system of NO2.
Tik pred začetkom uporabe pri vsakem bolniku morate opraviti pravilen postopek, s katerim sistem očistite NO2.
Most of it traverses the pulmonary capillary bed where it combines with haemoglobin that is 60 % to 100 % oxygen-saturated.
Večina ga prehaja skozi pljučne kapilare, kjer se veže na hemoglobin, ki je od 60 % do 100 % nasičen s kisikom.
Pregnancy and breastfeeding
Nosečnost in dojenje
Infants who cannot be weaned off INOmax by 4 days should undergo careful diagnostic work-up for other diseases.
Pri otrocih, pri katerih zdravljenja z zdravilom INOmax ne morete prekiniti po 4 dneh, opravite temeljit pregled za diagnosticiranje drugih obolenj.
The upper limit of exposure (mean exposure) to nitric oxide for personnel defined by worker's legislation is 25 ppm for 8 hours (30 mg/m3) in most countries and the corresponding limit for NO2 is 2-3 ppm (4-6 mg/m3).
Zgornja meja izpostavljenosti (srednja izpostavljenost) dušikovemu oksidu za osebje, ki jo določa delavska zakonodaja v večini držav, je 25 ppm v 8 urah (30 mg/m3) in ustrezna omejitev za NO2 je 2-3 ppm (4-6 mg/m3).
If you or your child receive more INOmax than you should
Če ste vi ali vaš otrok prejeli večji odmerek zdravila INOmax, kot bi smeli
Empty gas cylinders will be collected by the supplier.
Prazne jeklenke mora prevzeti dobavitelj.
The frequency and number of adverse events were similar in the two study groups.
Pogostnost in število neželenih učinkov sta bila v obeh skupinah podobna.
The prospectively defined primary endpoint was the receipt of ECMO.
Vnaprej določeni primarni rezultat je bil začetek zdravljenja z ECMO.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, even after you or your child leave the hospital, please tell your doctor.
Če opazite katerikoli neželeni učinek, ki ni omenjen v tem navodilu, tudi ko vi ali vaš otrok zapustite bolnišnico, obvestite otrokovega zdravnika.
Low blood pressure or a rebound increase in pressure in the lungs has been known to occur if treatment with INOmax is stopped suddenly without first lowering the dose.
Znano je, da se pojavi nizek krvni tlak ali povratno povišanje tlaka v pljučih, če se zdravljenje z zdravilom INOmax prekine nenadno, ne da bi najprej postopoma manjšali odmerek.
Methaemoglobin concentrations increase during the first 8 hours of nitric oxide exposure.
Koncentracije methemoglobina narastejo v prvih 8 urah izpostavitve dušikovemu oksidu.
Read all of this leaflet carefully before you start using this medicine because it contains important information for you.
Pred začetkom uporabe natančno preberite navodilo, ker vsebuje za vas pomembne podatke!
The nitrogen dioxide (NO2) concentration and FiO2 must also be measured at the same site using calibrated and approved (CE-marked) monitoring equipment.
Na istem mestu merite tudi koncentracijo dušikovega dioksida (NO2) in FiO2 z uporabo umerjenih in odobrenih (z oznako CE) nadzornih naprav.
Other medicines and INOmax
Druga zdravila in zdravilo INOmax
Deterioration in oxygenation and elevation in PAP may also occur in neonates with no apparent response to INOmax.
Poslabšanje oksigenacije in povišanje PAP se lahko pojavita tudi pri novorojenčkih, pri katerih ni očitnega odziva na zdravilo INOmax.
INOmax should be used in ventilated newborn infants expected to require support >24 hours.
Zdravilo INOmax uporabljajte pri predihavanju novorojenčkov, ki potrebujejo podporo >24 ur.
D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND
D. POGOJI ALI OMEJITVE V ZVEZI Z VARNO IN
All gas cylinders should be returned to the supplier for disposal.
Vse jeklenke morate vrniti dobavitelju, da jih bo odstranil.
Care must be taken when INOmax is given at the same time as medicinal products containing prilocaine.
Potrebna je previdnost pri dajanju zdravila INOmax hkrati z zdravili, ki vsebujejo prilokain.
In children and adults with high blood pressure in the lungs, connected with heart surgery, INOmax is usually given for 24-48 hours.
Otrokom in odraslim, ki imajo visok krvni tlak v pljučih, povezan s kirurškim posegom na srcu, se zdravilo INOmax običajno daje 24-48 ur.
For patient safety, appropriate alarms must be set for INOmax (± 2 ppm of the prescribed dose), NO2 (1 ppm), and FiO2 (± 0.05).
Zaradi bolnikove varnosti poskrbite za ustrezne alarme za zdravilo INOmax (± 2 ppm predpisanega odmerka), NO2 (1 ppm) in FiO2 (± 0,05).
Treatment can be maintained up to 96 hours or until the underlying oxygen desaturation has resolved and the neonate is ready to be weaned from INOmax therapy.
Zdravljenje lahko traja do 96 ur, oziroma dokler obstoječa desaturacija s kisikom ni odpravljena in je novorojenček pripravljen na prekinitev zdravljenja z zdravilom INOmax.
The concentrations of methaemoglobin in the blood should be monitored, see section 4.2.
Koncentracijo methemoglobina v krvi morate nadzorovati (glejte poglavje 4.2).
Persistent Pulmonary Hypertension in the Newborn (PPHN) The maximum recommended dose of INOmax is 20 ppm and this dose should not be exceeded.
Persistentna pljučna hipertenzija pri novorojenčkih (PPHN) Največji priporočeni odmerek zdravila INOmax je 20 ppm in tega odmerka ne smete prekoračiti.
If you have any other questions on the use of this medicine, ask your doctor.
Če imate dodatna vprašanja o uporabi zdravila, se posvetujte z zdravnikom.
Special patient populations
Posebne skupine bolnikov
The INOT25 trial, studying the effects of iNO in hypoxic preterm neonates, did not show improvement in alive without BPD.
Preskušanje INOT25, ki je preučevalo učinke iNO pri hipoksičnih nedonošenčkih, ni pokazalo izboljšanja glede živih novorojenčkov brez BPD.
This includes optimising tidal volume/pressures and lung recruitment (surfactant, high frequency ventilation, and positive end expiratory pressure).
To vključuje optimiziranje dihalnega volumna/tlaka in okrepitev pljuč (surfaktant, visokofrekvenčno predihavanje ter pozitivni in ekspiratorni tlak).
Formation of NO2
Nastajanje NO2
INOmax has been safely administered with tolazoline, dopamine, dobutamine, steroids, surfactant, and high-frequency ventilation.
Zdravilo INOmax so varno uporabljali skupaj s tolazolinom, dopaminom, dobutaminom, steroidi, surfaktantom in pri visokofrekvenčnem predihavanju.
The overall occurrence of intraventricular haemorrhage was 114 (28.9 %) among the iNO treated as compared to 91 (22.9 %) among the control neonates.
Skupna pojavnost intraventrikularne krvavitve je bila 28,9-odstotna (114) pri skupini, ki so jo zdravili z iNO, v primerjavi z 22,9-odstotno (91) pri kontrolnih novorojenčkih.
Storage in the medical department
Shranjevanje v medicinskih oddelkih
Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system listed in Appendix V
Od zdravstvenih delavcev se zahteva, da poročajo o katerem koli domnevnem neželenem učinku zdravila na nacionalni center za poročanje, ki je naveden v Prilogi V.
Not known
Neznana
There are no adequate data from the use of nitric oxide in pregnant women.
Ni zadostnih podatkov o uporabi dušikovega oksida pri nosečnicah.
The gas cylinders should be transported with appropriate material in order to protect them from risks of shocks and falls.
Jeklenke morate prevažati z ustrezno opremo, da bi jih zaščitili pred nevarnostjo padcev in udarcev.
Available data suggest additive effects on central circulation, pulmonary artery pressure and right ventricular performance.
Razpoložljivi podatki kažejo na dodatne učinke na centralno cirkulacijo, tlak v pljučni arteriji in delovanje desnega prekata.
Methaemoglobin levels > 7 % were attained only in patients receiving 80 ppm, where they comprised 35 % of the group.
Koncentracije methemoglobina so bile >7 % le pri bolnikih, ki so prejemali 80 ppm, in sicer pri 35 % bolnikov v skupini.
If at any time the NO2 concentration exceeds 1 ppm, the nitric oxide dose should immediately be reduced.
Če koncentracija NO2 kadarkoli preseže 1 ppm, nemudoma zmanjšajte odmerek dušikovega oksida.
If it is judged that clinical response is inadequate at 4-6 hours after starting INOmax, the following should be considered.
Če ocenite, da je klinični odziv po 4-6 urah po začetku zdravljenja z zdravilom INOmax neustrezen,
In clinical studies treatment was often initiated before separation from Cardio Pulmonary Bypass.
V kliničnih študijah se je zdravljenje pogosto začelo pred ločitvijo od srčno-pljučnega obvoda.
The combined incidence of death and/or initiation of ECMO (the prospectively defined primary endpoint) showed a significant advantage for the nitric oxide treated group (46 % vs. 64 %, p=0.006).
Kombinirana incidenca smrti in/ali začetka zdravljenja z ECMO (vnaprej določen primarni rezultat) je pokazala značilno prednost pri skupini, ki so jo zdravili z dušikovim oksidom (46 % proti 64 %, p = 0,006).
Attempts to wean INOmax should be made after the ventilator support is substantially decreased or after 96 hours of therapy.
Uporabo zdravila INOmax prekinite po znatnem zmanjšanju podpore dihanju oziroma po 96 urah zdravljenja.
Higher exposures have not been investigated.
Izpostavljenosti večjim odmerkom niso raziskali.
The overall number of death at week 36 was slightly higher in the iNO group; 53/395 (13.4 %) as compared to control 42/397 (10.6 %).
Skupno število smrti pri 36. tednu je bilo nekoliko večje v skupini, ki je prejemala iNO: 53/395 (13,4 %), v primerjavi s kontrolno skupino
Your doctor will decide the correct dose of INOmax and will administer INOmax to you or your child's lungs through a system designed for delivering this gas.
Zdravnik bo določil pravilni odmerek zdravila INOmax in ga bo vam ali vašemu otroku v pljuča dovajal prek sistema, zasnovanega za dovajanje tega plina.
Inhaled nitric oxide combination with other vasodilators acting by the cGMP or cAMP systems should be done with caution.
Kombinacije dušikovega oksida in drugih vazodilatatorjev, ki delujejo na sisteme cGMP ali cAMP, je treba uporabljati previdno.
When the gas cylinder is empty, it should not be discarded.
Ko je jeklenka prazna, se ne sme zavreči.
The clinical significance of the chemical reactivity of nitric oxide in tissue is unknown.
Klinična pomembnost kemične reaktivnosti dušikovega oksida v tkivih ni znana.
Neonates with less than a full response at 20 ppm were evaluated for a response to 80 ppm nitric oxide or control gas.
Pri novorojenčkih, ki se niso polno odzivali pri vrednosti 20 ppm, so ocenili odzivnost pri 80 ppm dušikovega oksida ali kontrolnega plina.
A. MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
A. IZDELOVALEC (IZDELOVALCI), ODGOVOREN (ODGOVORNI) ZA SPROŠČANJE SERIJE
Methaemoglobin level should be measured within one hour after initiation of INOmax therapy, using an analyser which can reliably distinguish between foetal haemoglobin and methaemoglobin.
Koncentracijo methemoglobina morate meriti eno uro po začetku zdravljenja z zdravilom INOmax z uporabo analizatorja, ki zanesljivo razločuje med fetalnim hemoglobinom in methemoglobinom.
Training in administration The key elements that need to be covered in training hospital personnel are as follows.
Ključni elementi, ki jih je treba zajeti pri usposabljanju zdravstvenega osebja, so opisani v nadaljevanju.
The INOmax group had significantly improved oxygenation as measured by PaO2, OI, and alveolar-arterial gradient (p<0.001 for all parameters).
Skupina, ki je prejemala zdravilo INOmax, je imela značilno izboljšano oksigenacijo, ki so jo izmerili kot PaO2, OI (kisikov indeks) in alveolo-arterijski gradient (p < 0,001 za vse parametre).
In case of insufficient response the dose may be titrated after a minimum of 10 minutes.
Če odziv ni zadosten, se lahko odmerek titrira po najmanj 10 minutah.
Rebound reaction is the most commonly adverse reaction in association with the clinical use of INOmax.
Povratna reakcija je najpogostejši neželeni učinek, povezan s klinično uporabo zdravila INOmax.
Cylinders equipped with a standard valve hand-wheel cannot be used with the INOmax DSIR delivery system.
Jeklenk, opremljenih s standardnim ročnim kolesom ventila, ni mogoče uporabljati s sistemom za dovajanje INOmax DSIR.
The doctor will decide when to treat you or your child with INOmax and with other medicines, and will carefully supervise the treatment.
Zdravnik se bo odločil, kdaj naj vi ali vaš otrok prejemate zdravilo INOmax in druga zdravila, in bo pozorno spremljal zdravljenje.
Inhaled nitric oxide may not always be effective and thus other therapies may be considered necessary for you or your child.
Vdihavanje dušikovega oksida ne bo vedno učinkovito, zato boste vi ali vaš otrok morda potrebovali druge vrste zdravljenja.
Prilocaine, whether administered as oral, parenteral, or topical formulations may cause methaemoglobinaemia.
Prilokain, dan bodisi v peroralni, parenteralni ali topikalni obliki, lahko povzroči methemoglobinemijo.
Protect the gas cylinders from shocks, falls, oxidising and flammable materials, moisture, sources of heat or ignition.
Jeklenke zaščitite pred udarci, padci, oksidirajočimi in vnetljivimi materiali, vlago, viri toplote ali vžiga.
Tests show that dry nitric oxide mixtures can be used with most materials.
Preizkusi so pokazali, da suhe mešanice dušikovega oksida lahko uporabljamo z večino materialov.
In neonates with PPHN, INOmax can improve oxygenation (as indicated by significant increases in PaO2).
Pri novorojenčkih s PPHN lahko zdravilo INOmax izboljša oksigenacijo (na kar kaže značilno povečanje PaO2).
Butyl rubber, polyamide, and polyurethane should not be used.
Ne uporabljajte butilne gume, poliamida in poliuretana.