natgillin/translations-raw huggingface dataset:
In clinical studies, there has been no indication that patients 65 years of age or older are at increased risk of adverse events compared to patients younger than 65 years old.
V kliničnih študijah ni kazalo, da bi bili bolniki, stari 65 let ali več, bolj izpostavljeni tveganju za neželene učinke v primerjavi z bolniki, mlajšimi od 65 let.
Time to treatment failure (TTTF - months)
Čas do neuspeha zdravljenja (Time to treatment failure, TTTF - meseci)
Contains mannitol
Vsebuje manitol.
Your doctor will discuss with you the potential risk of taking pemetrexed during pregnancy.
Z zdravnikom se pogovorite o možnem tveganju pri prejemanju pemetrekseda v času nosečnosti.
ITT population and histology subgroups
NZ populacija in histološke podskupine
Creatinine clearance should be ≥ 45 ml/min.
Očistek kreatinina mora biti ≥ 45 ml/min.
The doctor or hospital pharmacist will work out the dose you need based on your height and weight.
Zdravnik ali bolnišnični farmacevt bo določil potrebni odmerek na podlagi vaše telesne višine in mase.
Use in combination with cisplatin
Uporaba v kombinaciji s cisplatinom
Further dilution is required, as below.
Raztopino je treba še dodatno razredčiti, kot je opisano spodaj.
Frequency estimate: Very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from available data).
Pogostnosti so določene kot: zelo pogosto (≥1/10), pogosto (≥ 1/100 in < 1/10), občasno (≥ 1/1.000 in < 1/100), redko (≥ 1/10.000 in < 1/1.000), zelo redko (< 1/10.000) in neznana pogostnost (ni mogoče oceniti iz razpoložljivih podatkov-spontanih poročil).
Loss of appetite
Izguba apetita
Live attenuated vaccines (except yellow fever, for which concomitant use is contraindicated): Risk of systemic, possibly fatal, disease.
Živa oslabljena cepiva (razen proti rumeni mrzlici, za katero je sočasna uporaba kontraindicirana): tveganje za sistemsko, potencialno smrtno bolezen.
The European Medicines Agency has waived the obligation to submit the results of studies with the reference medicinal product containing pemetrexed in all subsets of the paediatric population for the granted indications (see section 4.2 for information on paediatric use).
Evropska agencija za zdravila je odstopila od obveze za predložitev rezultatov študij z referenčnim zdravilom, ki vsebuje pemetreksed, za vse skupine pediatrične populacije za odobrene indikacije (za informacije o pediatrični uporabi glejte poglavje 4.2).
100% of previous dose
100% predhodnega odmerka
- if you have recently received or are about to receive a vaccine against yellow fever.
- če ste bili nedavno cepljeni ali boste kmalu cepljeni proti rumeni mrzlici.
If you are unsure, ask your doctor or pharmacist if any of your medicines are NSAIDs.
Če niste prepričani, vprašajte svojega zdravnika ali farmacevta, ali so katera od vaših zdravil NSAID-i.
This leaflet was last revised in month YYYY.
Navodilo je bilo nazadnje revidirano dne {MM/LLLL}.
Further dilution is required.
Raztopino je treba še dodatno razredčiti.
The primary efficacy analysis was based on the ITT population.
Prvotna analiza učinkovitosti je bila osnovana na NZ populaciji.
Particular attention should be paid to these patients, and caution exercised with use of other radiosensitising agents.
Pri teh bolnikih je potrebna posebna pozornost in previdnost pri uporabi drugih radiosenzitirajočih učinkovin.
Efficacy and safety were measured from the time of randomisation after completion of first-line (induction) therapy.
Učinkovitost in varnost sta bili merjeni od časa randomizacije po zaključku zdravljenja prve izbire (indukcije).
The total bilirubin should be ≤ 1.5-times upper limit of normal.
Celotni bilirubin mora biti ≤ 1,5-kratnika zgornje meje normalnih vrednosti.
All grades toxicity(%)
Toksičnost vseh stopenj (%)
The 1 year and 2 year survival rates for patients on pemetrexed were 58% and 32% respectively, compared to 45% and 21% for patients on placebo.
Stopnji preživetja pri 1 in pri 2 letih pri bolnikih, ki so prejemali pemetreksed, sta bili 58 % in 32 %, v primerjavi s 45 % in 21 % pri bolnikih, ki so prejemali placebo.
The pemetrexed maintenance safety profiles from the two studies JMEN and PARAMOUNT were similar.
Profila varnosti vzdrževalnega zdravljenja s pemetreksedom iz obeh študij, JMEN in PARAMOUNT, sta bila podobna.
It is not known whether pemetrexed is excreted in human milk, and adverse reactions on the breast-feeding child cannot be excluded.
Dojenje Ni znano, ali se pemetreksed izloča v materino mleko, in neželenih reakcij za dojenčka ne moremo izključiti.
Please tell your doctor if you are taking any medicine for pain or inflammation (swelling), such as medicines called “nonsteroidal anti-inflammatory drugs” (NSAIDs), including medicines purchased without a doctor's prescription (such as ibuprofen).
Prosimo, povejte svojemu zdravniku, če jemljete kaka zdravila proti bolečinam ali vnetju (oteklinam), denimo zdravila, imenovana “nesteroidna protivnetna zdravila” (NSAID-i), vključno z zdravili, ki ste jih dobili brez recepta (kot denimo, ibuprofen).
Therefore, patients should be cautioned against driving or operating machines if this event occurs.
Zato je treba bolnike opozoriti, da naj ne vozijo in upravljajo strojev, če se pojavi utrujenost.
Pemetrexed is primarily eliminated in the urine, with 70% to 90% of the administered dose being recovered unchanged in urine within the first 24 hours following administration.
Pemetreksed se primarno izloča z urinom, 70 % do 90 % danega odmerka najdemo nespremenjenega v urinu v prvih 24 urah po dajanju.
Many of the patients in whom these occurred had underlying risk factors for the development of renal events, including dehydration or pre-existing hypertension or diabetes.
Mnogi bolniki, pri katerih so se le-ti pojavili, so imeli v osnovi dejavnike tveganja za razvoj ledvičnih primerov, vključno z dehidracijo ali že prej obstoječo hipertenzijo ali diabetesom.
If you have heart disease or a history of heart disease, please tell your doctor.
Če imate bolezen srca ali če ste v preteklosti imeli bolezen srca, prosimo, da to poveste zdravniku.
Pre-medication regimen
Režim premedikacije
No relationships between AST (SGOT), ALT (SGPT), or total bilirubin and pemetrexed pharmacokinetics were identified.
Ugotovili niso nobenih razmerij med AST (SGOT), ALT (SGPT), ali celokupnim bilirubinom in farmakokinetiko pemetrekseda.
Vitamin B12 and folic acid are given to you to reduce the possible toxic effects of the anticancer treatment.
Vitamin B12 in folno kislino boste prejeli za zmanjšanje možnih toksičnih učinkov zdravljenja proti raku.
Taste change
Sprememba okusa
Children and adolescents There is no relevant use of pemetrexed in the paediatric population.
Otroci in mladostniki Pemetreksed ni primeren za uporabo pri pediatrični populaciji.
Polyglutamation is a time- and concentration-dependent process that occurs in tumour cells and, to a lesser extent, in normal tissues.
Poliglutamacija je proces, odvisen od časa in koncentracije, ki se dogaja v tumorskih celicah, in v manjšem obsegu v normalnih tkivih.
Calculate the dose and the number of Pemetrexed Pfizer vials needed.
Izračunajte odmerek in število potrebnih vial zdravila Pemetreksed Pfizer.
Most of these events resolved after pemetrexed withdrawal.
Večina od teh dogodkov je po prekinitvi zdravljenja s pemetreksedom izzvenela.
If concomitant administration of NSAIDs is necessary, patients should be monitored closely for toxicity, especially myelosuppression and gastrointestinal toxicity.
Če je sočasno dajanje NSAID-ov potrebno, je pri bolnikih potrebno skrbno spremljati toksičnost, predvsem mieolosupresijo in gastrointestinalno toksičnost.
All patients included in this study had an ECOG performance status 0 or 1.
Vsi bolniki, vključeni v to študijo, so imeli ECOG status učinka 0 ali 1.
Upon recovery, patients should be re-treated using the guidelines in Tables 1, 2, and 3, which are applicable for pemetrexed used as a single agent or in combination with cisplatin.
Po okrevanju bolnike ponovno zdravimo z uporabo smernic v Preglednicah 1, 2 in 3, ki veljajo za pemetreksed, če jo uporabljamo kot edino učinkovino ali v kombinaciji s cisplatinom.
Please tell your doctor or hospital pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Povejte svojemu zdravniku ali bolnišničnemu farmacevtu, če jemljete ali ste pred kratkim jemali katerokoli zdravilo, tudi če ste ga dobili brez recepta.
You may want to seek counselling on sperm storage before starting your therapy.
Morda se boste želeli pred začetkom zdravljenja posvetovati o shranjevanju sperme.
In vitro studies indicate that pemetrexed is actively secreted by OAT3 (organic anion transporter).
In vitro študije so pokazale, da se pemetreksed aktivno izloča z OAT3 (prenašalcem organskih anionov).
Pemetrexed total systemic exposure (AUC) and maximum plasma concentration increase proportionally with dose.
Celotna sistemska izpostavljenost pemetreksedu (AUC) ter največja plazemska koncentracija naraščata sorazmerno z odmerkom.
The polyglutamate forms are retained in cells and are even more potent inhibitors of TS and GARFT.
Poliglutamatne oblike se zadržujejo v celicah in so še močnejši zaviralci TS in GARFT.
Safety was assessed for patients who were randomised to receive pemetrexed (N=800).
Varnost je bila ocenjena pri bolnikih, ki so bili naključno izbrani za prejemanje pemetrekseda (N=800).
The high intra-individual variability of the coagulation status during diseases and the possibility of interaction between oral anticoagulants and anti-cancer chemotherapy require increased frequency of INR (International Normalised Ratio) monitoring, if it is decided to treat the patient with oral anticoagulants.
Velika različnost med posamezniki v koagulacijskem statusu v času bolezni ter možnost medsebojnega delovanja med peroralnimi antikoagulacijskimi učinkovinami ter kemoterapijo proti raku zahtevata povečano pogostnost spremljanja INR (International Normalised Ratio), če se odločimo za zdravljenje bolnika s peroralnimi antikoagulacijskimi učinkovinami.
The other ingredient is mannitol.
Druga sestavina zdravila je manitol.
** Which is derived from the term “renal/genitourinary other”.
** izhaja iz izraza “ledvični/sečila drugo”.
Pemetrexed should not be used during pregnancy unless clearly necessary, after a careful consideration of the needs of the mother and the risk for the foetus (see section 4.4).
Pemetrekseda med nosečnostjo ne smemo uporabljati, če to ni neobhodno potrebno, uporabimo pa ga le po skrbni preučitvi potreb matere in tveganja za plod (glejte poglavje 4.4).
Use an inactivated vaccine where it exists (poliomyelitis) (see section 4.4).
Uporabite inaktivirano cepivo, če to obstaja (poliomielitis) (glejte poglavje 4.4).
Kaplan-Meier plots of overall survival by histology
Kaplan-Meier-jeva grafa skupnega preživetja glede na histologijo
If a pemetrexed solution contacts the skin, wash the skin immediately and thoroughly with soap and water.
Če pride raztopina pemetrekseda v stik s kožo, kožo nemudoma in temeljito sperite z milom in vodo.
Pemetrexed is not a vesicant.
Pemetreksed ni mehurjevec.
No statistically significant differences in any other individual Grade 3/4/5 adverse reactions were seen with longer exposure.
Pri drugih posameznih neželenih učinkih stopnje 3/4/5 pa ni bilo zaznati statistično značilnih razlik pri dolgotrajnejši izpostavljenosti.
Abbreviations: ALT = alanine aminotransferase; AST = aspartate aminotransferase; CTCAE = Common Terminology Criteria for Adverse Event; NCI = National Cancer Institute; SGOT = serum glutamic oxaloacetic aminotransferase; SGPT = serum glutamic pyruvic aminotransferase.
Okrajšave: ALT = alaninska aminotransferaza; AST = aspartatna aminotransferaza; CTCAE = običajni terminološki kriteriji za neželene učinke; NCI = nacionalni inštitut za rakava obolenja; SGOT = serumska glutamat oksalocetna aminotransferaza; SGPT = serumska glutamat piruvična aminotransferaza.
Once in the cell, pemetrexed is rapidly and efficiently converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase.
Ko je enkrat v celici, se pemetreksed hitro in učinkovito pretvori z encimom folilpoliglutamatno sintetazo v poliglutamatne oblike.
There are no data from the use of pemetrexed in pregnant women; but pemetrexed, like other anti-metabolites, is suspected to cause serious birth defects when administered during pregnancy.
Podatkov o uporabi pemetrekseda pri nosečnicah ni, a za pemetreksed, kot za druge antimetabolite, sumimo, da povzroča resne prirojene okvare, če ga dajemo med nosečnostjo.
Subsequent vitamin B12 injections may be given on the same day as pemetrexed.
Kasnejše injekcije vitamina B12 lahko dajemo isti dan kot pemetreksed.
The use of pemetrexed should be avoided during pregnancy.
Uporabi pemetrekseda med nosečnostjo se izogibamo.
Response (n: qualified for response)
Odziv (N: ustrezen odziv)
This dose may be adjusted, or treatment may be delayed depending on your blood cell counts and on your general condition.
Ta odmerek lahko prilagodimo ali zdravljenje odložimo, odvisno od vašega števila krvnih celic ter vašega splošnega stanja.
Before each infusion you will have samples of your blood taken to evaluate if you have sufficient kidney and liver function and to check that you have enough blood cells to receive Pemetrexed Pfizer.
Pred vsako infuzijo vam bomo odvzeli vzorce krvi za vrednotenje delovanja vaših ledvic in jeter ter oceno, ali imate dovolj krvnih celic za prejemanje zdravila Pemetreksed Pfizer.
The efficacy analyses using PQ population are consistent with the analyses for the ITT population and support the non-inferiority of AC versus GC.
Analiza učinkovitosti z uporabo PK populacije je skladna z analizo NZ populacije in podpira prednost AC proti GC.
A total of 213 patients (48.3%) completed ≥ 6 cycles and a total of 103 patients (23.4%) completed ≥ 10 cycles of treatment with pemetrexed.
Skupno 213 bolnikov (48,3 %) je zaključilo ≥ 6 ciklov in skupno 103 bolniki (23,4 %) so zaključili ≥ 10 ciklov zdravljenja s pemetreksedom.
Of the randomised patients, 44.9% had a complete/partial response and 51.9% had a response of stable disease to pemetrexed plus cisplatin induction.
Izmed naključno izbranih bolnikov jih je 44,9 % doseglo popoln/delen odziv in 51,9 % jih je doseglo odziv stabilne bolezni na pemetreksed in indukcijsko zdravilo cisplatina.
At the time of this final survival analysis, 28.7% of patients were alive or lost to follow up on the pemetrexed arm versus 21.7% on the placebo arm.
V času te končne analize preživetja je bilo živih ali ni bilo na voljo za nadaljnje spremljanje 28,7 % bolnikov v kraku pemetreksed v primerjavi z 21,7 % v kraku s placebom.
Pain, redness, swelling or sores in your mouth Nausea
Bolečina, rdečina, otekanje ali rane v vaših ustih Slabost
Most of the patients in whom these events have been observed had pre-existing cardiovascular risk factors.
Večina bolnikov, pri katerih so take dogodke opažali, je imela v preteklosti srčnožilne dejavnike tveganja.
Progression-free survival (months)
Preživetje brez napredovanja (meseci)
If you would like to father a child during the treatment or in the 6 months following receipt of treatment, seek advice from your doctor or pharmacist.
Če bi radi med zdravljenjem ali v 6 mesecih po zdravljenju spočeli otroka, se pogovorite s svojim zdravnikom ali farmacevtom.
Due to the increased thrombotic risk in patients with cancer, the use of anticoagulation treatment is frequent.
Zaradi povečanega tveganja za trombozo pri bolnikih z rakavim obolenjem pogosto uporabljamo antikoagulacijsko zdravljenje.
A total of 169 patients (47.1%) completed ≥ 6 cycles maintenance treatment with pemetrexed, representing at least 10 total cycles of pemetrexed.
Skupno je 169 bolnikov (47,1 %) zaključilo ≥ 6 ciklov vzdrževalnega zdravljenja s pemetreksedom, kar predstavlja vsaj 10 polnih ciklov pemetrekseda.
If you are also receiving cisplatin, your doctor will make sure that you are properly hydrated and receive appropriate treatment before and after receiving cisplatin to prevent vomiting.
Če prejemate tudi cisplatin, bo zdravnik pred prejemanjem cisplatina in po njem preveril, ali ste ustrezno hidrirani ter da prejemate ustrezno zdravljenje za preprečevanje bruhanja.
This medicine is for single use only; any unused solution must be disposed of in accordance with local requirement.
To zdravilo je namenjeno samo enkratni uporabi, morebitno neporabljeno raztopino je treba odstraniti v skladu z lokalnim predpisom.
Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Podrobne informacije o tem zdravilu so dostopne na spletni strani Evropske agencije za zdravila http://www.ema.europa.eu
Patients must also receive an intramuscular injection of vitamin B12 (1,000 micrograms) in the week preceding the first dose of pemetrexed and once every three cycles thereafter.
Bolniki morajo prejeti tudi intramuskularno injekcijo vitamina B12 (1.000 mikrogramov) v tednu pred prvim odmerkom pemetrekseda in enkrat vsake tri cikluse zatem.
a Statistically significant for non-inferiority, with the entire confidence interval for HR well below the 1.17645 non-inferiority margin (p < 0.001).
Statistično pomembna za prednost, s celotnim intervalom zaupanja za RT znatno pod 1,17645 mejo prednosti (p < 0,001).
Patients must receive adequate anti-emetic treatment and appropriate hydration prior to and/or after receiving cisplatin (see also cisplatin Summary of Product Characteristics for specific dosing advice).
Bolniki morajo prejeti zadostno antiemetično zdravljenje, pred in/ali po prejemanju cisplatina jih moramo tudi ustrezno hidrirati (glejte tudi Povzetek glavnih značilnosti zdravila cisplatin za posebne nasvete o odmerjanju).
The risk is increased in subjects who are already immunosuppressed by their underlying disease.
Tveganje je povečano pri ljudeh, ki imajo že zaradi svoje osnovne bolezni oslabljeno delovanje imunskega sistema.
In clinical studies, patients with creatinine clearance of ≥ 45 ml/min required no dose adjustments other than those recommended for all patients.
V kliničnih študijah bolniki z očistkom kreatinina ≥ 45 ml/min niso potrebovali prilagajanja odmerkov, razen tistih prilagoditev, ki jih priporočamo za vse bolnike.
Results from in vitro studies with human liver microsomes indicated that pemetrexed would not be predicted to cause clinically significant inhibition of the metabolic clearance of medicinal products metabolised by CYP3A, CYP2D6, CYP2C9, and CYP1A2.
Izsledki študij in vitro s človeškimi jetrnimi mikrosomi so pokazali, da za pemetreksed ne pričakujemo, da bi povzročil klinično pomembno zaviranje presnovnega očistka zdravil, ki se presnavljajo s CYP3A, CYP2D6, CYP2C9 in CYP1A2.
Myelosuppression is usually the dose-limiting toxicity.
Mielosupresija običajno predstavlja toksičnost za omejitev odmerka.
Therefore, all patients treated with pemetrexed must be instructed to take folic acid and vitamin B12 as a prophylactic measure to reduce treatment-related toxicity (see section 4.2).
Zato moramo vsem bolnikom, zdravljenim s pemetreksedom, naročiti, naj jemljejo folno kislino in vitamin B12 kot preprečevalni ukrep za zmanjšanje toksičnosti, povezane z zdravljenjem (glejte poglavje 4.2).
**In the pemetrexed /cisplatin arm, randomised and treated (N=225) and fully supplemented (N=167).
**V veji zdravljenja s pemetreksed/cisplatinom, randomizirani in zdravljeni (N = 225) ter s popolnim dopolnjevanjem (N = 167).
The analysis of the impact of NSCLC histology on overall survival demonstrated clinically relevant differences in survival according to histology, see table below.
Analiza vpliva histologije NSCLC na skupno preživetje je pokazala klinično ustrezne razlike v preživetju glede na histologijo, glejte preglednico spodaj.
Alkaline phosphatase (ALP), aspartate aminotransferase (AST or SGOT), and alanine aminotransferase (ALT or SGPT) should be ≤ 3-times upper limit of normal.
Alkalna fosfataza (AF), aspartatna aminotransferaza (AST ali SGOT) in alaninska aminotransferaza (ALT ali SGPT) morajo biti ≤ 3-kratnik zgornje meje normalnih vrednosti.
Pemetrexed solutions are for single use only.
Raztopine pemetrekseda so namenjene samo enkratni uporabi.
Pemetrexed is mainly eliminated unchanged renally by tubular secretion and to a lesser extent by glomerular filtration.
Pemetreksed se izloča predvsem preko ledvic nespremenjen s tubulno sekrecijo in v manjšem obsegu z glomerulno filtracijo.
Very common
Zelo Pogosto
Most of the patients in whom these events have been observed had preexisting cardiovascular risk factors (see section 4.8).
Večina bolnikov, pri katerih so take dogodke opažali, je imela v preteklosti srčnožilne dejavnike tveganja (glejte poglavje 4.8).
Haemolytic anaemia (anaemia due to destruction of red blood cells) Hepatitis (inflammation of the liver)
Hemolitična anemija (slabokrvnost zaradi propada rdečih krvnih celic) Hepatitis (vnetje jeter)
In the event of suspected overdose, patients should be monitored with blood counts and should receive supportive therapy as necessary.
V primeru suma na preveliko odmerjanje moramo spremljati bolnikovo krvno sliko, po potrebi naj prejema podporno zdravljenje.
Extravasation should be managed by local standard practice as with other non-vesicants.
Ob ekstravazaciji ukrepajte skladno z lokalno ustaljeno prakso kot pri drugih učinkovinah, ki niso mehurjevci.
• Fever or infection (common): if you have a temperature of 38ºC or greater, sweating or other signs of infection (since you might have less white blood cells than normal which is very common).
• Povišana telesna temperatura ali okužba (pogosto): če se pojavi temperatura 38 ºC ali višja, znojenje ali drugi znaki okužbe (ker imate lahko manj belih krvničk kot normalno, kar je zelo pogosto).
If you have an accumulation of fluid around your lungs, your doctor may decide to remove the fluid before giving you Pemetrexed Pfizer.
Če se vam okrog pljuč nabira tekočina, se bo zdravnik morda odločil tekočino pred dajanjem zdravila Pemetreksed Pfizer odstraniti.
It is a white to either light yellow or green-yellow lyophilised powder.
Je bel do bodisi svetlo rumen bodisi zeleno-rumen liofiliziran prašek.
75% of previous dose
75% predhodnega odmerka 75% predhodnega odmerka
**** Combined term includes increased serum/blood creatinine, decreased glomerular filtration rate, renal failure and renal/genitourinary- other.
**** Skupni izraz vključuje povišan kreatinin v serumu/krvi, znižano stopnjo glomerulne filtracije, ledvično odpoved in ledvice/sečila - drugo.
Pemetrexed total systemic clearance is 91.8 ml/min and the elimination half-life from plasma is 3.5 hours in patients with normal renal function (creatinine clearance of 90 ml/min).
Celotni sistemski očistek pemetrekseda je 91,8 ml/min, razpolovni čas izločanja iz plazme je 3,5 ur pri bolnikih z normalnim ledvičnim delovanjem (očistek kreatinina 90 ml/min).
A significant increase in the incidence of possibly study-medicinal product-related Grade 3/4 neutropenia was observed with longer exposure to pemetrexed (≤6 cycles: 3.3%, >6 cycles: 6.4%: p=0.046).
Znatno povečanje pojavnosti nevtropenije stopnje 3/4, ki je lahko povezano s preučevanim zdravilom, so opazili pri dolgotrajnejši izpostavljenosti pemetreksedu (≤ 6 ciklov: 3,3 %, > 6 ciklov: 6,4 %: p=0,046).
Fatigue (tiredness)
Utrujenost (izčrpanost)
Clinically relevant toxicities with respect to gender were similar to the overall population in patients receiving pemetrexed plus cisplatin.
Klinično pomembne toksičnosti glede na spol so bile podobne v celotni populaciji pri bolnikih, ki so prejemali pemetreksed skupaj s cisplatinom.
The dose of Pemetrexed Pfizer is 500 milligrams for every square metre of your body's surface area.
Odmerek zdravila Pemetreksed Pfizer je 500 miligramov za vsak kvadratni meter površine vašega telesa.