natgillin/translations-raw huggingface dataset:
UN GHS Category 1 see “Serious damage to eyes” and/or “Irreversible effects on the eye”.
15–35 [5]
see “Eye Irritation” and/or “Reversible effects to the eye”.
Tamhane-Dunnettov test
UN GHS No Category
Dunnettov test
Validated test method A test method for which validation studies have been completed to determine the relevance (including accuracy) and reliability for a specific purpose.
Če je % učinka pri NOEC velik ali je % učinka pri LOEC majhen, poskusite uporabiti ECx.
Generally organic solvents should not exceed 1 % (v/v).
Dunnettov test
If cytoB is dissolved in DMSO, the total amount of organic solvent used for both the test chemical and cytoB should not exceed 1 % (v/v); otherwise, untreated controls should be used to ensure that the percentage of organic solvent has no adverse effect.
Hochberg, Y. in A. C. Tamhane (1987).
Aqueous solvents (saline or water) should not exceed 10 % (v/v) in the final treatment medium.
Multiple Comparison Procedures.
If other than well-established solvents are used (e.g. ethanol or acetone), their use should be supported by data indicating their compatibility with the test chemical, the test system and their lack of genetic toxicity at the concentration used.
Wiley, New York.
However, for thorough evaluation, which would be needed to conclude a negative outcome, all three following experimental conditions should be conducted using a short term treatment with and without metabolic activation and long term treatment without metabolic activation (see paragraphs 56, 57 and 58):
A simple method for analyzing overdispersion in clustered Poisson data.
Cells should be exposed to the test chemical without metabolic activation for 3-6 hours, and sampled at a time equivalent to about 1,5 - 2,0 normal cell cycle lengths after the beginning of treatment (19),
48, 577–585.
Appropriate techniques should be used to control any bias or drift when using an automated scoring system, for instance, flow cytometry, laser scanning cytometry or image analysis.
Rao, J. N. K. in Scott A. J. (1999).
Regardless of the automated platform is used to enumerate micronuclei, CBPI, RI, RPD, or RICC should be assessed concurrently.
Statistics in Medicine, št. 18, 1373–1385.
Kirsch-Volders, M. (1997).
Robertson, T., Wright F. T. in Dykstra R. L. (1988).
Mutation Research, Vol.
Order restricted statistical inference.
392/1-2, pp. 1-4.
Wiley.
Parry, J.M., A. Sors (1993).
Bruce-Versteegov model,
Mutation Research, Vol.
Michaelis-Mentenov model,
287/1, pp. 3-15.
Hillov model.
Fenech, M., A.A.
Bunke, O., Droge, B. in Polzehl, J. (1999).
Cytobios, Vol.
Collett, D. (2003).
43/172-173, pp. 233-246.
Modelling Survival Data in Medical Research, druga izdaja.
Kirsch-Volders, M. et al.
Chapman and Hall, London.
Environmental and Molecular Mutagenesis, Vol.
Draper, N. R., in Smith, H. (1999).
35/3, pp. 167-172.
Applied Regression Analysis, tretja izdaja.
Fenech, M. (2007).
Springer Series in Statistics, New York.
Nature Protocols, Vol.
O'Hara Hines, R. J. and J. F. Lawless (1993).
2/5, pp. 1084-1104.
Modelling Overdispersion in Toxicological Mortality Data Grouped over Time.
Mutation Research, Vol.
Biometrics, zv.
161/2, pp. 193-198.
49, str. 107–121.
Eastmond, D.A., J.D.
Wang, Q., D. L. Denton in R. Shukla (2000).
Environmental and Molecular Mutagenesis, Vol.
Applications and Statistical Properties Of Minimum Significant Difference-Based Criterion Testing In a Toxicity Testing Program.
13/1, pp. 34-43.
Environmental Toxicology and Chemistry, zv.
Eastmond, D.A., D. Pinkel (1990).
19, str. 113–117, 2000.
Mutation Research, Vol.
Med preskusom je treba vsaj enkrat na teden v vseh preskusnih posodah izmeriti raztopljeni kisik, temperaturo in vrednost pH.
234/5, pp. 9-20.
Skupno trdoto in alkalnost je treba vsaj enkrat na teden izmeriti v kontrolah in eni posodi pri najvišji koncentraciji.
Farooqi, Z., F. Darroudi, A. T. Natarajan (1993).
US Environmental Protection Agency, Washington, DC, 104 str.
Mutagenesis, Vol.
OECD Environmental Health and Safety Publications Series on Testing and Assessment, št. 94, Pariz.
8/4, pp. 329-334.
103/Dop.
Migliore, L. et al.
7:173–8 Review.
Mutation Research, Vol.
Androgenic and estrogenic effects of the synthetic androgen 17alpha-methyltestosterone on sexual development and reproductive performance in the fathead minnow (Pimephales promelas) determined using the gonadal recrudescence assay.
319/3, pp. 205-213.
Aquatic Toxicology, zv.
Norppa, H., L. Renzi, C. Lindholm (1993).
68(3): 277–91.
Mutagenesis, Vol.
76(3–4): 343–52.
8/6, pp. 519-525.
Toxicological Sciences, 67(1): 121–30.
Mutation Research, Vol.
Obdobje osvetljenosti (svitanje in mrak sta neobvezna, vendar se ne štejeta za potrebna)
372/2, pp. 233-245.
16 ur svetlobe, 8 ur teme
Zijno, P. et al.
81, 90–98.
Kirsch-Volders et al.
Sci., Tokyo Univ., IV, 2: 209–218.
Mutation Research, Vol.
(Druge metode se lahko uporabijo, če se izvajajo na ledu in zagotovijo homogeno maso.)
540/2, pp. 153-163.
Opozorilo: epruvete je treba ustrezno oštevilčiti, da se lahko glava in rep ribe povežeta z ustreznim delom telesa, uporabljenim za histologijo spolnih žlez.
Mutation Research, Vol.
Neenake variance
607/1, pp. 88-124.
ISO (2007).
Mutation Research, Vol.
Kakovost vode – Določevanje akutne toksičnosti odpadnih voda na jajčeca cebric (Danio rerio).
Albertini, S. et al.
DarT: The embryo test with the zebrafish (Danio rerio) – a general model in ecotoxicology and toxicology.
392/1-2, pp. 187-208.
Testing acute toxicity in embryo of zebrafish, Brachydanio rerio as alternative to the acute fish test – preliminary results.
Mutation Research, Vol.
Comparison of testing acute toxicity on embryo of zebrafish (Brachydanio rerio), and RTG-2 cytotoxicity as possible alternatives to the acute fish test.
Gesellschaft fur Umwelt-Mutations-forschung, Mutation Research, Vol.
Groth, G., Kronauer, K. in Freundt, K. J. (1994).
Kalweit, S. et al.
Nguyen, L. T. in Janssen, C. R. (2001).
Mutation Research, Vol.
28: 1970–1978.
von der Hude, W. et al.
298 str.
517/1-2, pp. 123-134.
Ocene toksičnih končnih točk za spremenljivke odziva, npr. EC50, EC10, EC20, in povezani intervali zaupanja.
Mutagenesis, Vol.
Vrednosti LOEC in/ali NOEC, če sta izračunani, in statistične metode za njuno določitev.
Elhajouji, A., E. Lorge (2006).
11/2, str. 157–167.
607/1, pp. 1-152.
„Če se postopek začne z nesterilnimi rastlinami, zbranimi na terenu, se jeseni naberejo zarodni brstiči Myriophyllum sibiricum.
Kirkland, D. (2010).
Zarodni brstiči se položijo v 20-litrski akvarij, ki vsebuje 5 cm sterilne usedline, prekrite s kremenčevim peskom ali na primer z glino Turface® in 18 l vode z reagentom.
702/2, pp. 139-147.
Rastlinska kultura v akvariju se lahko vzdržuje kot pomožni vir rastlin, če mehanska okvara v termostatirani celici za rast, kontaminacija ali drug dejavnik uničijo kulturo sterilizirane rastline.
Hashimoto K. et al.
Rastline, ki rastejo v akvariju, niso sterilne in sterilnih kultur ni mogoče vzdrževati v sistemu za gojenje serij.
Regulatory Toxicology and Pharmacology, Vol.
Za sterilizacijo kulture je treba rastline vzeti iz akvarija in približno 0,5 ure spirati pod tekočo deionizirano vodo.
59/1, pp. 28-36.
V aseptičnih pogojih v laminarni komori z zračnim tokom se rastline razkužujejo manj kot 20 min (da pobeli večina rastlinskega tkiva in je zelen le še rastoči vršiček) v 3-odstotni (w/v) raztopini natrijevega hipoklorita, ki vsebuje 0,01 % primerne površinsko aktivne snovi.
Zhang, L.S. et al.
Za pritrditev zamaška na posodo s kulturo se uporabi sloj laboratorijskega tesnila.
347/3-4, pp. 105-115.
Kot je prikazano z gojenjem na agarskih ploščah, morajo biti rastline sterilne in ostati sterilne osem tednov pred začetkom preskušanja.“
ECVAM (2006).
Sensitivity of submersed freshwater macrophytes and endpoints in laboratory toxicity tests, Environmental Pollution, zv.
ESAC (2006).
153, str. 199–206.
Mutagenesis, Vol 23/4, pp. 271-283.
62/8, str. 715–722.
A report from ICPEMC Task Group 9.
Laboratory culture of submersed freshwater macrophytes on natural sediments, Aquatic Botany, zv.
257/2, pp. 147-205.
Christensen, E. R., N. Nyholm (1984).
Brusick, D. (1986).
11/10, 1485–1494.
8/6, pp. 789-886.
An equation to describe dose-responses where there is stimulation of growth at low doses, Weed Research, zv.
Mutation Research, Vol.
29/2, str. 93–96.
49, pp. 439-452.
Zadostno število vrednosti za pKa se iz vrednosti pH in absorbance pri izbrani valovni dolžini izračuna tako, da se uporabijo podatki za vsaj 5 vrednosti pH, pri katerih je snov ionizirana v razponu od vsaj 10 % do manj kot 90 %.
Mutation Research, Vol.
DODATEK K PRESKUSNI METODI B.5 [5]
147/1-2, pp. 29-36.
ZAPOREDNO TESTIRANJE DRAŽENJA OČI IN JEDKOSTI ZA OČI
Mutation Research, Vol.
Globalno usklajeni sistem za razvrščanje in označevanje kemikalij (GHS), ST/SG/AC.10/30.
392, pp. 11-18.
Rev. 4, New York in Ženeva: Združeni narodi.
Payne, C.M. et al.
Globalno usklajeni sistem za razvrščanje in označevanje kemikalij (GHS), četrta revidirana izdaja, ZN New York in Ženeva, 2011.
Nutrition and Cancer, Vol.
M. (1993).
62/6, pp. 825-840.
Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the Draize eye irritation test with rabbits.
Bazin, E. et al.
Fenech, M. in Morley, A. A. (1985).
Environmental and Molecular Mutagenesis, Vol.
Fenech, M. in Morley, A. A. (1986).
51/3, pp. 251-259.
Garriott, M. L., Phelps J. B.in Hoffman, W.
Le Hegarat, L. et al.
P. (2002).
Mutagenesis, Vol.
Genotoxicity of a Freshwater Cyanotoxin,Cylindrospermopsin, in Two Human Cell Lines: Caco-2 and HepaRG.
25/6, pp. 555-560.
Environmental and Molecular Mutagenesis, zv.
Josse, R. et al.
Vendar so tukaj navedene vrednosti točnosti za preskus DPRA kot samostojno preskusno metodo zgolj okvirne, saj jo je treba obravnavati skupaj z drugimi viri informacij v okviru IATA in v skladu z določbami odstavka 9.
Mutagenesis, Vol.
Poleg tega je treba pri ocenjevanju metod za preobčutljivost kože, ki se ne izvajajo na živalih, upoštevati, da preskus LLNA ter druga testiranja na živalih razmer v proučevani vrsti, tj. pri človeku, ne odražajo v celoti.
27/3, pp. 295-304.
Na podlagi splošno razpoložljivih podatkov se je pokazalo, da se preskus DPRA lahko uporablja za preskusne kemikalije, ki zajemajo različne organske funkcionalne skupine, mehanizme reakcije, stopnjo povzročanja preobčutljivosti kože (kot je določena v študijah in vivo) ter fizikalno-kemijske lastnosti (8) (9) (10) (19).
Ehrlich, V. et al.
Vse te informacije skupaj kažejo, da preskus DPRA uporabno prispeva k opredelitvi nevarnosti za povzročanje preobčutljivosti kože.
Mutagenesis, Vol.
Pojem „preskusna kemikalija“ se pri tej preskusni metodi nanaša na to, kar se preskuša, in ni povezan z uporabnostjo preskusa DPRA za preskušanje snovi in/ali zmesi.
17/3, pp. 257-260.
Ta preskusna metoda se ne uporablja za preskušanje kovinskih spojin, saj je znano, da z beljakovinami reagirajo z mehanizmi, ki niso kovalentna vezava.
Knasmüller, S. et al.
Toxicology in vitro 27: 609–618.
Toxicology, Vol.
OECD Environment, Health and Safety publications, Series on Testing and Assessment No 213, OECD, Pariz.
198/1-3, pp. 315-328.
OECD Environment, Health and Safety publications, Series on Testing and Assessment No.
37/1, pp. 31-45.
Vsak filter se vizualno pregleda in zabeleži se kakršna koli poškodba, ki je morda nastala med uporabo.
Mutation Research, Vol.
Količina fluoresceina, ki je prodrla skozi monosloj in vstavek, se količinsko opredeli v raztopini, ki je ostala v jamicah po odstranitvi vstavkov.
113/3-4, pp. 173-215.
teSS = 6,54 · 10 – 3 · 104 + 55,31 = 121 ur
Journal of Environmental Pathology and Toxicology, Vol.
Če se izkaže, da je ta metoda zagotovila slabo oceno za k1, se lahko za izračun k1 in k2 uporabi sočasni pristop.
4/1, pp. 55-65.
Prilagojeni model je treba znova primerjati z grafičnim prikazom izmerjenih podatkov, da se vizualno pregleda prileganje podatkov in pridobljene ocene parametrov za k1, k2 in dobljeni BKF, njihove standardne napake in/ali intervale zaupanja pa je treba primerjati z različnimi vrstami prileganja.
Elliott, B.M. et al.
H. (1971).
Mutagenesis, Vol.
A Primer of Population Biology.
7, pp. 175-177.
OECD (2012).
28, pp. 51-59.
ASTM (1988).
UNEP (2001).
Standard Guide for Conducting Early Life-Stage Toxicity Tests with Fishes.
Mutation Research, Vol.190/3, pp. 225-8.
A. in B. R. Jones (1977).
Environmental Mutagenesis, Vol.
Temperature Criteria for Freshwater Fish: Protocol and Procedures.
5/6, pp. 795-801.
Ecological Research Series EPA-600/3-77-061, Duluth, Minnesota.
Mutation Research, Vol.
Hutchinson, T. H. et al.
652/2, pp. 122-130.
Devlin, E. W. et al.
Fenech, M. (1993).
USEPA, Office of Research and Development, Washington, D.C.
Mutation Research, Vol.
Dunnett, C. W.
285/1, pp. 35-44.
A multiple comparisons procedure for comparing several treatments with a control.
Phelps, J.B., M.L.
Journal of Ameican Statistical Association, 50, 1096–1121.
Mutation Research, Vol.
Ta meritev torej ne vključuje dolžine repne plavuti (www.fishbase.org).
521/1-2, pp. 103-112.
IUPAC: Mednarodna zveza za čisto in uporabno kemijo.
Mutation Research, Vol.
SMILES: sistem za poenostavljen zapis strukture molekul.
655/1-2, pp. 1-3.
Transformacija za stabilizacijo varianc?
Surralles, J. et al.
Dunnov ali Mann- Whitneyjev test Ali so podatki normalno porazdeljeni, homogeni po arkus sinus-korenski pretvorbi?
Mutation Research, Vol.
OECD (2006a).
341/3, pp. 169-184.
Rose, J. et al.
Honma, M. (2011).
Tatarazako, N. et al.
Mutation Research, Vol.
Screening and testing for endocrine disruption in fish-biomarkers as „signposts,“ not „traffic lights,“ in risk assessment.
724, pp. 86-87.
Environmental Health Perspectives, zv.
Pfuhler, S. et al.
OECD (2006c).
Mutation Research, Vol.
Current Approaches in the Statistical Analysis of Ecotoxicity Data: A Guidance to Application.
723/2, pp. 101-107.
OECD Environmental Health and Safety Publications, Series on Testing and Assessment, št. 54, OECD, Pariz.
OECD (2014).
US EPA (2008).
Morita T., M. Honma, K. Morikawa (2012).
Peer-Review Results for the Fish Short-Term Reproduction Assay, z dne 30. januarja 2008.
Mutation Research, Vol.
25 ± 2 °C
741, pp. 32-56.
26 ± 2 °C
Brookmire L., J.J.
Ankley, G. T., Jensen, K. M., Makynen, E. A., Kahl, M. D., Korte, J. J., Hornung, M. W., Henry, T. R., Denny, J. S., Leino, R. L., Wilson, V. S., Cardon, M. C., Hartig, P. C., Gray, E. L. (2003).
Environmental and Molecular Mutagenesis, Vol.
Braunbeck, T., Böttcher, M., Hollert, H., Kosmehl, T., Lammer, E., Leist, E., Rudolf, M. in Seitz, N. (2005).
54/1, pp. 36-43.
Towards an alternative for the acute fish LC50 test in chemical assessment: The fish embryo toxicity test goes multi-species-an update.
EPA, Office of Chemical Safety and Pollution Prevention (2011).
Bachmann, J. (2002).
Sobol, Z. et al.
Development and validation of a teratogenicity screening test with embryos of the zebrafish (Danio rerio).
Mutation Research, Vol.746/1, pp. 29-34.
Knöbel, M., Busser, F. J. M., Rico-Rico, A., Kramer, N. I., Hermens, J. L. M., Hafner, C., Tanneberger, K., Schirmer, K., Scholz, S. (2012).
Mutation Research, Vol.
Belanger, S. E., Rawlings J. M. in Carr G. J. (2013).
120/4, pp. 241-247.
Lammer, E., Carr, G. J., Wendler, K., Rawlings, J. M., Belanger, S. E., Braunbeck, T. (2009).
MacGregor, J. T., C.M.
Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test?
Bryce, S.M. et al.
Kubota, A., Stegeman, J. J., Woodin, B. R., Iwanaga, T., Harano, R., Peterson, R. E., Hiraga, T., Teraoka, H. (2011).
Environmental and Molecular Mutagenesis, Vol.
Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2.
52/4, pp. 280–286.
Lammer, E., Kamp, H. G., Hisgen, V., Koch, M., Reinhard, D., Salinas, E. R., Wendlar, K., Zok, S., Braunbeck, T. (2009).
Environmental and Molecular Mutagenesis, Vol.
Brown, R. S., Akhtar, P., Åkerman, J., Hampel, L., Kozin, I. S., Villerius, L. A., Klamer, H. J. C., (2001).
52/5, pp. 355–362.
Partition controlled delivery of hydrophobic substances in toxicity tests using poly(dimethylsiloxane) (PDMS) ﬁlms.
Mutagenesis, Vol.
How to deal with lipophilic and volatile organic substances in microtiter plate assays.
25/1, pp. 33-40.
ISO (1996).
Fenech, M. et al.
Mednarodni standardi.
Jaworska et al.
Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals, Environmental and Molecular Mutagenesis, zv.
Bauch et al.
10/dod.
Nukada et al.
„Analysis of Data from In Vitro Cytogenetic Assays“, in Statistical Evaluation of Mutagenicity Test Data, Kirkland, D. J. (ed.), Cambridge University Press, Cambridge, str. 141–154.
Ball et al (2011).
UKEMS SubCommittee on Guidelines for Mutagenicity Testing, Report, Part III, Kirkland, D. J. (ur.), Cambridge University Press, Cambridge, str. 184–232.
Lepoittevin et al.
NIH št. publikacije: 07-4517.
EC EURL ECVAM (2012).
Series on Testing and Assessment, št. 189, OECD, Pariz.
Direct Peptide Reactivity Assay (DPRA) Validation Study Report 74pp.
NIH št. publikacije: 10-7553A.
Natsch et al.
36: 106–117.
DB-ALM (INVITTOX) Protocol 154: Direct Peptide Reactivity assay (DPRA) for skin sensitisation testing 17pp.
NIH št. publikacije: 06-4512.
OECD (2005).
24, str. 1–9.
FDA (Food and Drug Administration (2001).
NIH št. publikacije: 06-4513.
ECETOC (2003).
Protocol 80: Chicken enucleated eye test (CEET) / Isolated Chicken Eye Test, str. 13.
Relevance incorporates consideration of the accuracy (concordance) of a test method (21).
In Vitro, 9: 871–929.
The proportion of all negative/inactive chemicals that are correctly classified by the test method.
Toxicology in Vitro 20: 78–81.
It is a measure of accuracy for a test method that produces categorical results and is an important consideration in assessing the relevance of a test method (21).
19, str. 471–480.
Determination of instrument performance (e.g. sensitivity) by analysis of a reference standard prior to running the analytical batch (22).
372/2, str. 211–219.
Test chemical
The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity.
The term “test chemical” is used to refer to what is being tested.
Mutation Research, zv.
90-100
Mutagenesis, zv.
60-80
Mutation Research, zv.
10-55
Stockholmska konvencija o obstojnih organskih onesnaževalih, Program Združenih narodov za okolje (UNEP).
30-60
10/dod.
0-24
Analysis of Data from in vitro Cytogenetic Assays. in Statistical Evaluation of Mutagenicity Test Data, Kirkland, D. J. (ed), Cambridge University Press, Cambridge, str. 141–154.
80-100
Globalno usklajeni sistem za razvrščanje in označevanje kemikalij (GHS): peta prenovljena izdaja, ZN New York in Ženeva, 2013.
0-7
Archives of Toxicology 85: 367–485.
15-55
Toxicological Sciences 81: 332–343.
0-25
Toxicological Sciences 97: 417–427.
60-100
Journal of Applied Toxicology, spletna različica, 14. maj 2013, DOI: 10.1002/jat.2869.
10-45
Regulatory Toxicology and Pharmacology 63: str. 489–504.
0-5,5
Regulatory Toxicology and Pharmacology 60: 389–400.
The medium is then removed and replaced with fresh culture medium (150 μl culture medium containing serum but without Geneticin in the case of KeratinoSensTM) to which 50 μl of the 25 fold diluted test chemical and control substances are added.
Journal of Experimental Medicine 64: 625–639.
At least one well per plate should be left empty (no cells and no treatment) to assess background values.
Journal of Applied Toxicology, spletna različica, 9. april 2013, DOI:10.1002/jat.2868.
Finally, for test chemicals generating a 1,5 fold or higher induction already at the lowest test concentration of 0,98 μM, the EC1,5 value of < 0,98 is set based on visual inspection of the dose-response curve.
Guidance for Industry: Bioanalytical Method Validation str. 22.
Acceptance criteria
European Centre for Ecotoxicology & Toxicology of Chemicals (Technical Report No. 87).
Adler S., Basketter D., Creton S., Pelkonen O., van Benthem J., Zuang V., Andersen K.E., Angers-Loustau A., Aptula A., Bal-Price A., Benfenati E., Bernauer U., Bessems J., Bois F.Y., Boobis A., Brandon E., Bremer S., Broschard T., Casati S., Coecke S., Corvi R., Cronin M., Daston G., Dekant W., Felter S., Grignard E., Gundert-Remy U., Heinonen T., Kimber I., Kleinjans J., Komulainen H., Kreiling R., Kreysa J., Leite S.B., Loizou G., Maxwell G., Mazzatorta P., Munn S., Pfuhler S., Phrakonkham P., Piersma A., Poth A., Prieto P., Repetto G., Rogiers V., Schoeters G., Schwarz M., Serafimova R., Tähti H., Testai E., van Delft J., van Loveren H., Vinken M., Worth A., Zaldivar J.M.
Globalno usklajeni sistem za razvrščanje in označevanje kemikalij (GHS), peta revidirana izdaja, ZN New York in Ženeva, 2013.
Archives of Toxicology 85, 367-485.
OECD, Pariz.
Emter R., Ellis G., Natsch A. (2010).
Na voljo na: http://www.oecd.org/document/54/0,3746,en_2649_34379_42923638_1_1_1_1,00.html.
Toxicology and Applied Pharmacology 245, 281-290.
Organisation for Economic Co-operation and Development (OECD), Pariz, Francija.
Dinkova-Kostova A.T., Holtzclaw W.D., Kensler T.W.
Department of Civil, Architectural and Environmental Engineering, University of Texas, Austin, TX, ZDA.
18, 1779-1791.
Pri zaporednem prilagajanju je priporočeno uporabiti enako pretvorbo podatkov.
Kansanen E., Kuosmanen S.M., Leinonen H., Levonen A.L.
Vizualni pregled pridobljenih naklonov, ko sta grafično prikazana v odvisnosti od izmerjenih podatkov o točkah vzorčenja, se lahko uporabi za oceno prileganja podatkov.
1(1), 45-49.
Danish Water Quality Institute, Hørsholm, Danska.
Natsch A., Bauch C., Foertsch L., Gerberick F., Normann K., Hilberer A., Inglis H., Landsiedel R., Onken S., Reuter H., Schepky A., Emter R. (2011).
Environmental Agency, Bristol, Združeno kraljestvo.
Journal of Applied Toxicology, 33, 1337-1352.
Developmental Dynamics, 203: 253–310.
EURL-ECVAM (2014).
Current Approaches in the Statistical Analysis of Ecotoxicity Data: A Guidance to Application, Environmental Health and Safety Publications Series on Testing and Assessment, št. 54, OECD, Pariz.
Natsch A., Emter R., Ellis G. (2009).
Agresti, A. (2002).
Ball N., Cagen S., Carrillo J.C., Certa H., Eigler D., Emter R., Faulhammer F., Garcia C., Graham C., Haux C., Kolle S.N., Kreiling R., Natsch A., Mehling A. (2011).
Technometrics, št. 6, 241–252.
60, 389-400.
Dunnett, C. W.
Bauch C., Kolle S.N., Ramirez T., Eltze T., Fabian E., Mehling A., Teubner W., van Ravenzwaay B., Landsiedel R. (2012).
A multiple comparison procedure for comparing several treatments with a control.
63, 489-504.
J. American Statistical Association, št. 50, 1096–1121.
Toxicology In Vitro 27, 1220-1225.
Multiple Comparisons: Theory and Methods.
Fabian E., Vogel D., Blatz V., Ramirez T., Kolle S., Eltze T., van Ravenzwaay B., Oesch F., Landsiedel R. (2013).
Chapman and Hall/CRC Press, Boca Raton.
87, 1683-1969.
Jonckheere, A. R. (1954).
Thorne N., Inglese J., Auld D.S.
A distribution-free k-sample test against ordered alternatives.
Chemistry and Biology 17, 646-657.
28, 519–531.
Gildea L.A., Ryan C.A., Foertsch L.M., Kennedy J.M., Dearman R.J., Kimber I., Gerberick G.F.
Williams, D. A. (1975).
Technical Working Group on Pesticides — (Quantitative) Structure Activity Relationship ((Q)SAR) Guidance Document.
Aquatic Toxicology, zv.
Imax
CEFIC, Bruselj, Belgija.
The suggested NC chemical is calcium-containing (at a concentration of 1,0-1,8 mM), phenol red-free, HBSS (untreated, blank control).
Thorpe, K. L., Benstead, R., Hutchinson, T. H., Tyler, C. R., 2007.
A maximum leakage control should also be included in each run to allow for the calculation of FL20 values.
Oka, T. B. (1931).
(mg/ml)
PhD-thesis, Technical University of Dresden, Nemčija.
UN GHS C&L EU CLP C&L
http://iccvam.niehs.nih.gov/methods/ocutox/OcuAnest- TMER.htm.
U.S. EPA C&L
OECD (1998).
UN (2009), United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Third revised edition, New York & Geneva: United Nations Publications.
Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, kakor je bil potrjen na 28. skupnem zasedanju Odbora za kemikalije in Delovne skupine za kemikalije, november 1998 (http://www.oecd.org/ehs/Class/HCL6.htm).