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Target tissue Tissue in which a principal adverse effect of a toxicant is manifested.
Model abstract care utilizează limbajul matematic pentru a descrie comportamentul unui sistem.
Feed should be withheld during the exposure period. Water may be provided throughout a whole-body exposure.
Animalele nu ar trebui să fie hrănite pe perioada de expunere a întregului corp. Apa poate fi furnizată pe tot parcursul expunerii întregului corp.
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Testing at ≥ 20000 ppm/4h: see Guidance Document 39 (8) -------------------------------------------------- Appendix 2d Acute Inhalation Toxicity:
Testare la ≥ 20 000 ppm/4h: a se vedea documentul de orientare 39 (8)
Testing at ≥ 20000 ppm/4h: see Guidance Document 39 (8) --------------------------------------------------
0-6: Numărul de animale muribunde sau moarte/concentrație testată
Appendix 3c Starting concentration is 10 mg/l Appendix 3d Starting concentration is 20 mg/l Depending on the number of humanely killed or dead animals, the test procedure follows the indicated arrows.
Apendicele 3b concentrația inițială este 2 mg/l.
Appendix 3a Acute Inhalation Toxicity:
În funcție de numărul de animale moarte sau eutanasiate, procedura de testare de urmat este indicată prin săgeți.
0-6: Number of moribund or dead animals/tested concentraion - GHS: Globally Harmonized Classification System - ∞: unclassified
Procedură de testare cu o concentrație inițială de 0,5 mg/l/4h pentru vapori
Testing at 50 mg/L/4h: see Guidance Document 39 (8) -------------------------------------------------- Appendix 3b Acute Inhalation Toxicity:
3 ♂ + 3 ♀, sau 6 animale din sexul cel mai susceptibil sunt utilizate pe etapă
Testing at 50 mg/L4h: see Guidance Document 39 (8) -------------------------------------------------- Appendix 3c Acute Inhalation Toxicity:
3 ♂ + 3 ♀, sau 6 animale din sexul cel mai susceptibil sunt utilizate pe etapă
0-6: Number of moribund or dead animals/tested concentraion GHS: Globally Harmonized Classification System ∞: unclassified Testing at 50 mg/L/4h: see Guidance Document 39 (8) -------------------------------------------------- Appendix 3d Acute Inhalation Toxicity:
Procedură de testare cu o concentrație inițială de 10 mg/l/4h pentru vapori
Test procedure with a starting concentration of 20 mg/L/4h for vapours 3 ♂ + 3 ♀, or 6 animals of the more susceptible sex are used per step
3 ♂ + 3 ♀, sau 6 animale din sexul cel mai susceptibil sunt utilizate pe etapă
For each starting concentration, the respective testing schemes as included in this Appendix outline the procedure to be followed. Appendix 4a Starting concentration is 0,05 mg/l
Pentru fiecare concentrație inițială, ar trebui urmate diferitele scheme de testare conținute în prezentul apendice.
Appendix 4a Acute Inhalation Toxicity:
În următoarele tabele se face referire la GHS (Sistemul global armonizat de clasificare și etichetare a substanțelor chimice (GHS). Echivalentul UE este Regulamentul (CE) nr. 1272/2008. În cazul toxicității acute prin inhalare, Regulamentul (CE) nr. 1272/2008 (9) nu pune în aplicare Categoria 5.
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x mean development rate per vessel i index of inspection interval m maximum number of inspection intervals i number of midges emerged in the inspection interval i n e
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Tabelul 1
Table 1 Stock solutions of trace elements for medium M4 and M7
Soluții stoc de microelemente pentru mediile M4 și M7
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When the percentage degradation is a lower value than expected, IC is possibly accumulated in the test solution. Then, the degradability may be assessed with the other ready biodegradability tests.
Atunci când procentul de degradare are o valoare mai scăzută decât cea preconizată, este posibil ca în soluția experimentală să se acumuleze CA. În acest caz, degradabilitatea poate fi evaluată folosind celelalte teste de biodegradabilitate rapidă.
After shaking for one hour at the test temperature the bottles are removed from the shaker, aliquots (e.g. 1 ml) of gas are withdrawn from the headspace of each bottle and injected into the IC analyser. The measured IC concentrations are recorded as mg C/l.
După agitarea timp de o oră la temperatura de testare, flacoanele sunt scoase din agitator, sunt extrase alicote de gaz (de exemplu, 1 ml) din spațiul liber al fiecărui flacon și sunt injectate în analizorul de CA. Concentrațiile de CA măsurate sunt înregistrate în mg C/l.
Before each batch of analyses, the IC analyser is calibrated using an appropriate standard — for example, a solution of sodium bicarbonate (NaHCO3) in CO2 free water (see paragraph 53) in the range 0 to 20 mg/l as IC. Sodium hydroxide solution (7M, paragraph 21) (e.g. 1 ml to 107 ml medium) is injected through the septum of each bottle sampled and the bottles are shaken for 1 h at the test temperature.
Înainte de analizarea fiecărei serii, analizorul de CA se calibrează folosind un standard adecvat – de exemplu, o soluție de bicarbonat de sodiu (NaHCO3) în apă fără CO2 (a se vedea punctul 53) în intervalul 0-20 mg/l CA. Soluția de hidroxid de sodiu (7M, punctul 21) (de exemplu, 1 ml la 107 ml de mediu) se injectează prin dopul fiecărui flacon folosit pentru prelevare, iar flacoanele sunt agitate timp de 1 h la temperatura de testare.
The samples are injected into the IC analyser and the concentrations of IC are recorded. It should be ensured that the analyser used is equipped properly to deal with the alkaline samples produced in this method.
Probele sunt injectate în analizorul de CA și sunt înregistrate concentrațiile de CA. Ar trebui să se asigure faptul că analizorul utilizat este dotat corespunzător pentru a trata probele alcaline produse prin această metodă.
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