Rare: - reduction in red blood cells (anaemia), increase in white blood cells (leucocytosis), alteration of the prothrombin (coagulation factor) values, reduction in blood platelets (thrombocytopenia) with bruises and tendency to bleed, increase in blood platelets (thrombocytosis) - swelling of the limbs and face (peripheral oedema, facial oedema), sudden swelling of the face or throat with difficulties in breathing and/or itching and rash, often as an allergic reaction (angioneurotic oedema), allergic reactions, fever due to the administration of the medicine, serious allergic reaction which causes difficulty in breathing or dizziness (anaphylactic reaction) - increased blood sugar level (hyperglycaemia) - anxieties, nightmares, severe depression, seeing things or hearing voices that do not exist (hallucinations) - reduced taste, altered sensation (paraesthesia), shaking (tremor), spasms/ convulsions (seizures), severe headache (migraine) - altered vision such as double vision (diplopia) and seeing all objects in a certain colour (chromatopsia) - ringing in the ear (tinnitus), transient hearing loss (particularly high frequencies) - increased heart rate (tachycardia) - fainting (syncope), widening of blood vessel (vasodilation) - shortness of breath (dyspnoea), swelling of the voice box (larynx) with difficulties in breathing (larynx oedema) - severe and continuous diarrhoea, possibly with blood and mucus, due to a severe inflammation of the large intestine (pseudo membranous colitis), fungal infection in the mouth (oral moniliasis) - yellowing of the skin or whites of the eyes (icterus), icterus due to a condition where the bile can not flow normally from the liver (cholestatic icterus), liver cell necrosis - increased sensitivity to light (photosensitivity), erythema multiforme and erythema nodusum - muscular pain (myalgia), joint disorder (swollen joints) - acute kidney failure, abnormal kidney function, vaginal secretion due to a fungal infection (vaginal moniliasis), blood in the urine (haematuria), presence of crystals in the urine with discomfort when passing urine (crystalluria), infection of the kidney with blood in the urine, fever and pain in the side (interstitial nephritis)
Rare: - scăderea numărului de celule roşii ale sângelui (anemie), creşterea numărului de celule albe ale sângelui (leucocitoză), modificarea valorilor protrombinei (factor de coagulare), scăderea numărului de trombocite (thrombocitopenie) cu vânătăi şi tendinţă de sângerare, creşterea numărului de trombocite (trombocitoză) - umflarea extremităţilor şi a feţei (edem periferic, edem facial), inflamarea bruscă a feţei şi gâtului cu dificultăţi de respiraţie şi/sau mâncărime şi erupţii pe piele, deseori ca reacţie alergică (edem angioneurotic), reacţii alergice, febră în urma administrării medicamentului, reacţii alergice grave cu dificultăţi de respiraţie şi ameţeli (reacţii anafilactice) - creşterea valorii zahărului în sânge (hiperglicemie) - anxietate, coşmaruri, depresie accentuată, impresii vizuale şi auditive ale unor lucruri inexistente (halucinaţii) - diminuarea simţului gustativ, amorţeală (parestezie), tremurături (tremor), spasme/ convulsii, dureri de cap accentuate (migrenă) - tulburări de vedere, cum sunt: vedere dublă (diplopie) şi impresie subiectivă de a vedea toate obiectele într-o anumită culoare (cromatopsie) - zgomote în urechi (tinitus), pierderea tranzitorie a auzului (în special a frecvenţelor înalte)