Pain, Pain in the lower abdomen, abdominal discomfort, gastrointestinal pain, abnormal accumulation of fluid in abdomen, bowel obstruction (especially the ileum), oropharyngeal pain, inflammation of mouth and lips, dry mouth, olfactory dysfunction, abnormal pancreas function, pancreas acute inflammation, colon inflammation, blood in faeces, black faeces, anxiety, rapid and irregular heartbeat, palpitations, chest discomfort, conjunctivitis, eye disorders, dry skin, excessive and profuse perspiration, generalized itching, thrombocytopenic purpura, local and face swelling, formication or sensation of pins and needles (pricking, burning, tingling or numbing sensation), impaired brain function due to liver disease, abnormal results of blood test (hypernatraemia, hypophosphatemia, hypercalcaemia, hypercalcaemia, hypocalcaemia, hypoalbuminaemia, potassium decreased, urea increased, glycosylated haemoglobin increased, hematocrit decrease, presence of catecholamines, C reactive protein increased, creatine phospho kinnase increased, lactate dehydrogenase increased), low sugar level in the blood, flatulence, abnormal results of urine test (presence of leukocytes), increased parathyroid hormone levels in the blood, acute or chronic abnormal proliferation of leukocytes, dissolution or destruction of cells (Tumor lysis syndrome), fever, rash, paleness of the skin, peripheral coldness, sleep disorders (feeling sleepy), hallucinations, urinary incontinence, widening of blood vessels, vertigo, malaise, disturbances related to tumour disintegration, loss of weight, bone marrow cancer (acute myeloid leukaemia), bone marrow failure, bladder inflammation (cystitis), death, heart attack, pneumonia, unusual amount of fluid collection around the lungs (pleural effusion), increased sputum, renal or prerenal functions disturbances, muscle spasms, carcinoid crisis, abnormal feeling, physical disability, disorientation, abnormal electrocardiogram (QT prolongation), cardiogenic shock, orthostatic hypotension, phlebitis, chocking sensation, vomiting blood, abnormal bile flow from liver to duodenum (cholestasis), liver injury or congestion, abnormally high acidity of the blood and other body tissues (metabolic acidosis), clavicle fracture, surgical/ medical procedures have been exceptionally reported (polypectomy, stent placement, gastrointestinal tube insertion, dialysis, abdominal cavity drainage and abscess drainage).
insuficiență a măduvei osoase, inflamație a vezicii urinare (cistită), deces, infarct miocardic, pneumonie, colectare a unei cantități neobișnuite de lichid în jurul plămânilor (efuziune pleurală), creștere a producerii de spută, tulburări ale funcțiilor renale sau prerenale, spasme musculare, criză carcinoidă, senzație de rău, dizabilitate fizică, dezorientare, electrocardiogramă anormală (prelungirea QT), șoc cardiogen, tensiune arterială mică când stați în picioare, flebită, senzație de sufocare, vărsături cu sânge, flux anormal de bilă din ficat în duoden (colestază), leziuni sau congestie la nivelul ficatului, aciditate anormal de mare a sângelui și a altor țesuturi ale corpului (acidoză metabolică), fracturi de claviculă, în mod excepțional au fost raportate proceduri chirurgicale/medicale (polipectomie, plasare a unui stent, introducere a tubului gastrointestinal, dializă, drenajul cavității abdominale și drenajul abcesului).