natgillin/translations-raw huggingface dataset:
amodiaquine and chloroquine (used to treat malaria and some forms of inflamamtion),
amodiakin i klorokin (koristi se za liječenje malarije i nekih oblika upale),
Among 1,151 patients receiving atazanavir 400 mg once daily, 177 patients were co-infected with chronic hepatitis B or C, and among 655 patients receiving atazanavir 300 mg once daily with ritonavir 100 mg once daily, 97 patients were co-infected with chronic hepatitis B or C. Co-infected patients were more likely to have baseline hepatic transaminase elevations than those without chronic viral hepatitis.
Od 1151 bolesnika koji su primali atazanavir 400 mg jedanput na dan, 177 bolesnika istovremeno je imalo kroničnu infekciju virusom hepatitisa B ili C, dok je od 655 bolesnika koji su primali atazanavir 300 mg jedanput na dan s ritonavirom 100 mg jedanput na dan, 97 bolesnika istovremeno imalo kroničnu infekciju virusom B ili C. Bolesnici s istovremenim infekcijama češće su imali povišene jetrene transaminaze na početku liječenja nego oni bez kroničnog virusnog hepatitisa.
Among 1,151 patients receiving atazanavir 400 mg once daily, 177 patients were co-infected with chronic hepatitis B or C, and among 655 patients receiving atazanavir 300 mg once daily with ritonavir 100 mg once daily, 97 patients were co-infected with chronic hepatitis B or C. Co-infected patients were more likely to have baseline hepatic transaminase elevations than those without chronic viral hepatitis.
Od 1151 bolesnika koji su primali atazanavir u dozi od 400 mg jedanput na dan, njih 177 imalo je istodobnu kroničnu infekciju virusom hepatitisa B ili C, dok je među 655 bolesnika koji su primali atazanavir u dozi od 300 mg jedanput na dan s ritonavirom u dozi od 100 mg jedanput na dan, njih 97 imalo istodobnu kroničnu infekciju virusom hepatitisa B ili C. U bolesnika s istodobnim infekcijama postojala je veća vjerojatnost povišenih vrijednosti jetrenih transaminaza na početku liječenja nego u onih bez kroničnog virusnog hepatitisa.
Among 1,968 treatment-experienced patients receiving PREZISTA co-administered with ritonavir 600/100 mg twice daily, 236 patients were co-infected with hepatitis B or C. Co-infected patients were more likely to have baseline and treatment emergent hepatic transaminase elevations than those without chronic viral hepatitis (see section 4.4).
Od 1968 prethodno liječenih bolesnika, a primali su lijek PREZISTA primjenjen istodobno s ritonavirom od 600/100 mg dva puta na dan, 236 bolesnika bilo je istodobno inficirano hepatitisom B ili C. Bolesnici s takvom koinfekcijom češće su imali povišene početne jetrene transaminaze i one neposredno uzrokovane liječenjem nego bolesnici bez kroničnog virusnog hepatitisa (vidjeti dio 4.4).
Among 15 subjects treated with open-label Cinryze for laryngeal HAE attacks, none required intubation.
U 15 ispitanika otvoreno liječenih lijekom Cinryze zbog laringealnog napadaja HAE ni u jednog nije bila potrebna intubacija.
Among 31 treatment-naïve adult patients treated with velaglucerase alfa, the mean lumbar spine BMD Z-score at baseline was -1.820 (95% CI: -2.21, -1.43) and increased by 0.62 (95% CI: 0.39, 0.84) from baseline following 24 months of treatment with velaglucerase alfa.
Od 31 odraslih bolesnika liječenih velaglucerazom alfa koji nisu bili prethodno liječeni, srednji Z-rezultat BMD-a lumbalne kralježnice na početku ispitivanja bio je -1,820 (95% CI: -2,21, - 1,43) i povećao se za 0,62 (95% CI: 0,39, 0,84) u odnosu na početnu vrijednost nakon 24 mjeseca liječenja velaglucerazom alfa.
Among 465 subjects in the paediatric safety database (including a further 67 subjects from the extension phase of the controlled clinical trial) there were
Među 465 ispitanika u bazi podataka koja se odnosi na sigurnost pedijatrijskih ispitanika (uključujući dodatnih 67 ispitanika iz faze produžetka kontroliranog kliničkog ispitivanja), bilo je 7 smrtnih slučajeva (1,5%;
Among 49 patients who received at least one dose of Eviplera, 100% of patients remained suppressed (HIV-1 RNA < 50 copies/mL) at week 12 and week 24.
Od 49 pacijenata koji su primili barem jednu dozu lijeka Eviplera, 100% pacijenata ostalo je suprimirano (HIV-1 RNK < 50 kopija/ml) u 12. i 24. tjednu.
Among 497 patients initially randomized to apremilast 30 mg twice daily, 375 (75%) patients were still on this treatment on Week 52.
Od 497 bolesnika koji su na početku ispitivanja randomizirani na apremilast od 30 mg dvaput na dan, 375 (75%) bolesnika bilo je još uvijek na toj terapiji u 52. tjednu.
Among 593 patients treated with Teysuno in combination with cisplatin, the most common severe adverse reactions (Grade 3 or higher with frequency of at least 10%) were neutropaenia, anaemia, and fatigue.
U 593 bolesnika liječenih lijekom Teysuno u kombinaciji s cisplatinom, najčešće zabilježene teške nuspojave (stupnja 3 ili višeg s učestalošću namanje 10%) bile su neutropenija, anemija i umor.
Among 69 hypophosphatasia patients enrolled in the clinical trials and who have post baseline data, 56 (81.2%) tested positive for anti-drug antibodies at some time point after receiving Strensiq treatment.
Od 69 bolesnika s hipofosfatazijom uključenih u klinička ispitivanja, a za koje su postojali podaci poslije početka ispitivanja, njih 56 (81,2%) imalo je pozitivne rezultate testa na protutijela protiv lijeka u nekoj vremenskoj točki nakon što su liječeni Strensiqom.
Among 7 patients with preexisting cirrhosis and/or portal hypertension who received lumacaftor/ivacaftor in the placebo-controlled, Phase 3 studies, worsening liver function with increased ALT, AST, bilirubin, and hepatic encephalopathy was observed in one patient.
Među 7 bolesnika s postojećom cirozom i/ili portalnom hipertenzijom koji su primali lumakaftor/ivakaftor u placebom kontroliranim ispitivanjima faze 3, u jednog bolesnika opaženo je pogoršanje funkcije jetre s povećanim ALT-om, AST-om, bilirubinom i hepatičkom encefalopatijom.
Among 795 patients randomized, the majority were males (84%), white (73%), current or former smokers (95%) with baseline performance status ECOG 1 (67%) and ECOG 0 (33%).
Od 795 randomiziranih bolesnika, većina su bili muškarci (84%), bijelci (73%), aktivni ili bivši pušači (95%) s početnim funkcionalnim stanjem ECOG 1 (67%) i ECOG 0 (33%).
Among 9 boys with left ventricular mass (LVMI) indexed to height2.7 within the normal range for children (<39 g/m2.7 in boys) at baseline, LVMI remained stable at levels below the left ventricular hypertrophy (LVH) threshold throughout the 6.5 years of treatment.
Od 9 dječaka s masom lijevih ventrikula (engl. left ventricular mass, LVMI) indeksiranom na visinu2,7 unutar raspona normalnih vrijednosti za djecu (<39 g/m2,7 u dječaka) na početku ispitivanja, LVMI je ostao stabilan na razinama ispod praga hipertrofije lijevog ventrikula (engl. left ventricular hypertrophy, LVH) tijekom 6,5 godina liječenja.
Among a subgroup with baseline CrCL 30 to 50 mL/min death occurred in 16.7% (9/54) of patients who received Zavicefta and metronidazole and 6.8% (4/59) of patients who received meropenem.
U podskupini s vrijednosti CrCL na početku od 30 do 50 ml/min, smrt je nastupila u 16,7% (9/54) bolesnika koji su primali lijek Zavicefta i metronidazol te u 6,8% (4/59) bolesnika koji su primali meropenem.
Among age and body-size related covariates tested, age was a significant covariate on apparent clearance of sunitinib (the younger the age of the paediatric patient, the lower the apparent clearance).
Od testiranih varijabli povezanih s dobi i veličinom tijela, dob je bila značajna varijabla za prividni klirens sunitiniba (što je mlađa dob pedijatrijskih bolesnika, to je niži prividni klirens).
Among all patients treated in clinical trials (including both those with severe neutropenia and those who did not develop severe neutropenia), 11 % (4 % of courses) developed fever and 26 % (9 % of courses) developed infection.
Među svim bolesnicima liječenjim u kliničkim ispitivanjima (uključujući one s teškom neutropenijom i one koji nisu razvili tešku neutropeniju), 11% (4% ciklusa) je razvilo vrućicu, a 26% bolesnika (9% ciklusa) je razvilo infekciju.
Among all patients treated in clinical trials (including both those with severe neutropenia and those who did not develop severe neutropenia), 11 % (4 % of courses) developed fever and 26 % (9 % of courses) developed infection.
Među svim bolesnicima u kliničkim ispitivanjima (uključujući one s teškom neutropenijom i bez nje), 11% (4% ciklusa) je razvilo vrućicu, a 26% bolesnika (9% ciklusa) infekciju.
Among all randomised and treated patients, the median change from baseline in CD4+ cell count at the last measurement up to Week 48 was +23 cells/mm3 in patients receiving tipranavir with ritonavir (N=740) versus +4 cells/mm3 in the comparator PI/ritonavir (N=727) arm.
Uzimajući u obzir sve randomizirane i liječene bolesnike medijan razlike broja CD4+ stanica između zadnjeg mjerenja (najdulje nakon 48 tjedana) i vrijednosti prije početka liječenja, iznosio je +23 stanice/mm3 za ispitivanu (N=740) i +4 stanice/mm3 za kontrolnu skupinu (N=727).
Among all randomised and treated patients, the median change from baseline in CD4+ cell count at the last measurement up to Week 48 was +23 cells/mm3 in patients receiving tipranavir with ritonavir (N=740) versus +4 cells/mm3 in the comparator PI/ritonavir (N=727) arm.
Uzimajući u obzir sve randomizirane i liječene bolesnike medijan razlike broja CD4+ stanica između zadnjeg mjerenja (najdulje nakon 48 tjedana) i vrijednosti prije početka liječenja, iznosio je +23 stanice/mm3 za ispitivanu skupinu (N=740) i +4 stanice/mm3za kontrolnu skupinu (N=727).
Among all randomised and treated patients, the median change from baseline in HIV-1 RNA at the last measurement up to Week 48 was -0.64 log10 copies/ml in patients receiving tipranavir with ritonavir versus -0.22 log10 copies/ml in the comparator PI/ritonavir arm.
Uzimajući u obzir sve randomizirane i liječene bolesnike medijan razlike HIV-1 RNA između zadnjeg mjerenja (najdulje nakon 48 tjedana) i vrijednosti prije početka liječenja, iznosio je -0,64 log10 kopija/ml za ispitivanu i - 0,22 log10 kopija/ml za kontrolnu skupinu.
Among all randomised and treated patients, the median change from baseline in HIV-1 RNA at the last measurement up to Week 48 was -0.64 log10 copies/ml in patients receiving tipranavir with ritonavir versus -0.22 log10 copies/ml in the comparator PI/ritonavir arm.
Uzimajući u obzir sve randomizirane i liječene bolesnike, medijan razlike HIV-1 RNA između zadnjeg mjerenja (najdulje nakon 48 tjedana) i vrijednosti prije početka liječenja, iznosio je -0,64 log10 kopija/ml za ispitivanu i -0,22 log10 kopija/ml za kontrolnu skupinu.
Among Bexsero recipients, 5849 were infants and children (less than 2 years of age), 250 were children (2 to 10 years of age) and 2677 were adolescents and adults.
Od primatelja Bexsera, 5849 su bili dojenčad i djeca (mlađa od 2 godine), 250 su bila djeca (u dobi od 2 do 10 godina), a 2677 su bili adolescenti i odrasli.
Among children and adolescents, treated with Ribavirin in combination with interferon alfa- 2b, suicidal ideation or attempts were reported more frequently compared to adult patients (2.4% versus 1%) during treatment and during the 6-month follow-up after treatment.
U djece i adolescenata liječenih lijekom Ribavirin Mylan u kombinaciji s interferonom alfa-2b suicidalne misli ili pokušaji samoubojstva prijavljeni su češće nego u odraslih bolesnika (2,4 % u odnosu na 1 %), i to tijekom liječenja i tijekom šestomjesečnog praćenja nakon završetka liječenja.
Among children and adolescents, treated with Ribavirin Teva Pharma B.V. in combination with interferon alfa-2b, suicidal ideation or attempts were reported more frequently compared to adult patients (2.4 % versus 1 %) during treatment and during the 6-month follow-up after treatment.
U djece i adolescenata liječenih lijekom Ribavirin Teva Pharma B.V u kombinaciji s interferonom alfa-2b suicidalne misli ili pokušaji samoubojstva prijavljeni su češće nego u odraslih bolesnika (2,4% u odnosu na 1%), i to tijekom liječenja i tijekom šestomjesečnog praćenja nakon završetka liječenja.
Among children and adolescents, treated with Ribavirin Teva Pharma B.V. in combination with interferon alfa-2b, suicidal ideation or attempts were reported more frequently compared to adult patients (2.4 % versus 1 %) during treatment and during the 6-month follow-up after treatment.
U djece i adolescenata liječenih lijekom Ribavirin Teva Pharma B.V. u kombinaciji s interferonom alfa-2b suicidalne misli ili pokušaji samoubojstva prijavljeni su češće nego u odraslih bolesnika (2,4% u odnosu na 1%), i to tijekom liječenja i tijekom šestomjesečnog praćenja nakon završetka liječenja.
Among children who were not already shedding virus at baseline, the incidence of laboratory-confirmed clinical influenza was reduced from 21 % (15 / 70) in the group not receiving prevention to 4 % (2 / 47) in the group receiving prevention (80.1 % reduction [95 % CI 22.0 – 94.9; p = 0.0206]).
Među djecom koja na početku nisu bila nositelji virusa došlo je do smanjenja incidencije laboratorijski potvrđene klinički izražene gripe: od 21 % (15/70) u skupini u kojoj nije provedena prevencija, na 4 % (2/47) u skupini u kojoj je prevencija provedena (smanjenje od 80,1 % [95 % CI 22,0 - 94,9; p = 0,0206]).
Among co-infected patients in study 006, elevations in AST to greater than five times ULN developed in 13% of efavirenz-treated patients and in 7% of control, and elevations in ALT to greater than five times ULN developed in 20% and 7%, respectively.
Među koinficiranim bolesnicima u studiji 006, porast AST-a više od pet puta iznad gornje granice normale zabilježen je u 13% bolesnika koji su primali efavirenz i u 7% u kontrolnoj skupini, a porast ALT-a više od pet puta iznad gornje granice normale zabilježen je u 20% bolesnika na efavirenzu i u 7% bolesnika u kontrolnoj skupini.
Among co-infected patients in study 006, elevations in AST to greater than five times ULN developed in 13% of efavirenz-treated patients and in 7% of controls, and elevations in ALT to greater than five times ULN developed in 20% and 7%, respectively.
Među koinficiranim bolesnicima u ispitivanju 006 porast AST-a više od pet puta iznad GGN zabilježen je u 13% bolesnika koji su primali efavirenz i u 7% u kontrolnoj skupini, a porast ALT-a više od pet puta iznad GGN zabilježen je u 20% bolesnika na efavirenzu i u 7% bolesnika u kontrolnoj skupini.
Among co-infected patients, 3% of those treated with efavirenz and 2% in the control arm discontinued because of liverdisorders (see section 4.4).
Među koinficiranim bolesnicima, 3% onih liječenih efavirenzom i 2% onih iz kontrolne skupine prekinulo je liječenje zbog poremećaja funkcije jetre (vidjeti dio 4.4).
Among genotype 1a-infected subjects, NS5A resistance-associated substitutions persisted at detectable levels at follow-up week 12 in 95% (35/37) of subjects and in 100% (9/9) of subjects with follow-up week 24 data.
Među ispitanicima s infekcijom genotipom 1a, supstitucije povezane s rezistencijom u NS5A bile su i dalje prisutne u mjerljivim količinama u 95% (35/37) ispitanika u 12. tjednu praćenja te u 100% (9/9) ispitanika u 24. tjednu praćenja.
Among genotype 1a-infected subjects, the median age was 54 years (range: 19 to 76); 71 % were male; 71 % were White; 22 % were Black or African American; 9% were Hispanic or Latino; 74% were treatment-naïve subjects; 26% were treatment-experienced subjects; mean body mass index was 27 kg/m2; 75 % had baseline HCV RNA levels greater than 800,000 IU/mL; 23 % had cirrhosis; 72% had non-C/C IL28B alleles (CT or TT); 30 % had HCV/HIV-1 co-infection.
Među ispitanicima s infekcijom genotipom 1a, medijan dobi iznosio je 54 godine (raspon: 19 do 76); 71% ispitanika bili su muškarci; 71% bili su bijelci; 22% bili su crnci ili Afroamerikanci; 9% bili su hispanoameričkog ili latinoameričkog podrijetla; 74% ispitanika prethodno nije bilo liječeno, dok je njih 26% prethodno primalo liječenje; srednja vrijednost indeksa tjelesne mase iznosila je 27 kg/m2; 75% ispitanika je na početku ispitivanja imalo vrijednost HCV RNK iznad 800 000 IU/ml; 23% imalo je cirozu; 72% imalo je alele IL28B koji nisu bili genotipa C/C (CT ili TT), a njih 30% imalo je istodobnu HCV/HIV-1 infekciju.
Among imatinib-intolerant patients, the estimated rate of PFS was 98% (95% CI: [95%-100%]) at 1 year and 94% (95% CI: [88%-99%]) at 2 years.
U bolesnika koji nisu podnosili imatinib, procijenjena stopa PFS iznosila je 98% (95% CI: [95%- 100%]) nakon 1 godine i 94% (95% CI: [88%-99%]) nakon 2 godine.
Among imatinib-resistant patients, the estimated rate of PFS was 88% (95% CI: [84%-92%]) at 1 year and 75% (95% CI: [69%-81%]) at 2 years.
Među bolesnicima otpornima na imatinib, procijenjena stopa preživljenja bez progresije bolesti (PFS) iznosila je 88% (95% CI: [84%-92%]) nakon 1 godine te 75% (95% CI: [69%-81%]) nakon 2 godine.
Among lamivudine-refractory patients with baseline HBV DNA < 107 log10 copies/ml, 64% (9/14) achieved HBV DNA < 300 copies/ml at Week 48.
Od bolesnika s bolešću refrakternom na lamivudin i početnom HBV DNK < 107 log10 kopija/ml, 64% (9/14) je postiglo HBV DNK < 300 kopija/ml u 48. tjednu.
Among patients in the SBR arm who maintained their baseline regimen for 24 weeks and then switched to FTC/RPV/TDF, 92% (140/152) of patients had HIV-1 RNA < 50 copies/mL after 24 weeks of FTC/RPV/TDF, consistent with the Week 24 results for patients who switched to FTC/RPV/TDF at baseline.
Od pacijenata u SBR skupini liječenoj koji su zadržali svoj početni režim 24 tjedna i potom su se prebacili na FTC/RPV/TDF, 92% (140/152) pacijenata imalo je HIV-1 RNA < 50 kopija/ml nakon 24 tjedna FTC/RPV/TDF, dosljedno rezultatima iz 24. tjedna za pacijente koji su se na početku prebacili na FTC/RPV/TDF.
Among patients in the warfarin group, INR values were within the therapeutic range (2.0 to 3.0) a mean of 55% of the time (median, 58%; interquartile range, 43 to 71).
Među bolesnicima u skupini varfarin INR vrijednosti bile su u terapijskom rasponu (2,0 do 3,0) – srednja vrijednost od 55% vremena (medijana, 58%; raspon među kvartilima, 43 do 71).
Among patients in the warfarin group, INR values were within the therapeutic range (2.0 to 3.0) a mean of 55% of the time (median, 58%; interquartile range, 43 to 71).
Među bolesnicima u skupini varfarin, INR vrijednosti bile su u terapijskom rasponu (2,0 do 3,0) – srednja vrijednost od 55% vremena (medijana, 58%; raspon među kvartilima, 43 do 71).
Among patients randomised to other comparators, the incidence of symptomatic hypoglycaemia was 7% to 33% when used with a sulphonylurea or insulin and 2% to 4% in combinations without these medicinal products.
Među bolesnicima koji su bili randomizirani za primanje drugih usporednih lijekova, incidencija simptomatske hipoglikemije iznosila je 7% do 33% kod istodobne primjene sulfonilureje ili inzulina te 2% do 4% u kombinacijama koje nisu uključivale ta dva lijeka.
Among patients receiving dual anti-platelets therapy 98.8% received clopidogrel, 0.9 % received ticlopidine and 0.3 % received prasugrel.
Među bolesnicima koji su primali dvostruku antitrombocitnu terapiju, 98,8 % primalo je klopidogrel, 0,9 % primalo je tiklopidin, a 0,3 % primalo je prasugrel.
Among patients receiving Enbrel, the clinical responses generally appeared within 1 to 2 weeks after initiation of therapy and nearly always occurred by 3 months.
Među bolesnicima koji su primali Enbrel, klinički odgovor javio se općenito unutar 1 do 2 tjedna od početka liječenja, a gotovo uvijek nakon 3 mjeseca liječenja.
Among patients remaining in the study and treated Simponi, improvement of the SF-36 physical component was similar from week 104 through week 256.
Među bolesnicima koji su ostali u ispitivanju i bili liječeni lijekom Simponi poboljšanje na fizičkoj komponenti upitnika SF- 36 bilo je slično od 104. do 256. tjedna.
Among patients remaining in the study and treated with Simponi, DAS28 and HAQ DI responses were similar from week 104 through week 256.
Među bolesnicima koji su ostali u ispitivanju i bili liječeni lijekom Simponi bile su opažene slične stope odgovora ACR 20/50/70 od 104. do 256. tjedna.
Among patients remaining in the study and treated with Simponi, similar rates of ACR 20/50/70 response was observed from week 104 through week 256.
Među bolesnicima koji su ostali u ispitivanju i bili liječeni lijekom Simponi bile su opažene slične stope odgovora ACR 20/50/70 od 104. do 256. tjedna.
Among patients remaining in the study and treated with Simponi, similar rates of patients showed no progression from baseline from week 104 through week 256.
Među bolesnicima koji su ostali u ispitivanju i bili liječeni lijekom Simponi radiografski učinci bili su slični od 104. do 256. tjedna.
Among patients remaining in the study and treated with Simponi, the proportion of patients with an ASAS 20 and ASAS 40 response were similar from week 24 through week 256.
456 bolesnika koji su ostvarili klinički odgovor na prethodnu uvodnu terapiju lijekom Simponi.
Among patients who completed a full 24 months of therapy in the study, the non-progression rates were 78%, 70%, and 61%, respectively.
Među bolesnicima koji su završili puna 24 mjeseca terapije u ispitivanju stopa ne- progresije je bila 78%, 70% odnosno 61%.
Among patients who remained on the apremilast treatment to which they were randomized at study start, DAS28(CRP) score and PsARC response were maintained through Week 52.
Među bolesnicima koji su ostali na terapiji apremilastom na koju su randomizirani na početku ispitivanja, rezultat DAS28(CRP) i odgovor PsARC održali su se do 52. tjedna.
Among patients who remained on the apremilast treatment to which they were randomized at study start, these improvements were maintained through Week 52.
Među bolesnicima koji su ostali na terapiji apremilastom na koju su randomizirani na početku ispitivanja, ova poboljšanja održala su se do 52. tjedna.
Among patients who remained on the apremilast treatment, to which they were initially randomized at study start, improvement in physical function and FACIT- fatigue was maintained through Week 52.
Među bolesnicima koji su ostali na terapiji apremilastom, na koju su bili randomizirani na početku ispitivanja, poboljšanje fizičkog funkcioniranja i rezultata za FACIT- umor održalo se do 52. tjedna.
Among patients who used anti-coagulant therapy, the frequency of haemorrhagic adverse events was similar in the OZURDEX and sham groups (29% vs 32%).
Među bolesnicima koji su primali antikoagulantnu terapiju učestalost neželjenog hemoragijskog događaja bila je slična učestalosti u skupini koja je primila OZURDEX u usporedbi s placebo skupinom (29% naspram 32%).
Among patients who were at least partial responders at Week 12, and who received continuous weekly Humira therapy, the HiSCR rate at Week 48 was 64.3%.
Među bolesnicima koji su u 12. tjednu ostvarili barem djelomičan odgovor i koji su nastavili terapiju lijekom Humira svaki tjedan, stopa HiSCR-a u 48. tjednu iznosila je 64,3%.
Among patients who were initially randomized to apremilast 30 mg twice daily treatment, ACR 20/50/70 response rates were maintained through Week 52 in the pooled Studies PALACE 1, PALACE 2 and PALACE 3 (Figure 1).
U objedinjenim ispitivanjima PALACE 1, PALACE 2 i PALACE 3, među bolesnicima koji su na početku ispitivanja randomizirani na terapiju apremilastom od 30 mg dvaput na dan, stope odgovora ACR 20/50/70 održale su se do 52. tjedna (slika 1).
Among patients who were initially randomized to apremilast 30 mg twice daily treatment, the change from baseline in the HAQ-DI score at week 52 was -0.333 in the apremilast 30 mg twice daily group in a pooled analysis of the open label phase of studies PALACE 1, PALACE 2 and PALACE 3.
Među bolesnicima koji su na početku ispitivanja randomizirani na terapiju apremilastom od 30 mg dvaput na dan, promjena rezultata HAQ-DI u 52. tjednu u odnosu na početni rezultat iznosila je -0,333 u skupini koja je primala apremilast od 30 mg dvaput na dan u analizi objedinjenih podataka otvorene faze ispitivanja PALACE 1, PALACE 2 i PALACE 3.