natgillin/translations-raw huggingface dataset:
Therefore, it may be necessary to combine Advocate treatment with treatments aimed at breaking the flea life cycle in the surroundings.
Stoga, ponekad je potrebno kombinirati primjenu Advocate Spot-on s tretiranjem okoliša usmjerenim na prekidanje razvojnog ciklusa buha u okolišu.
Therefore, it should be avoided in patients with rare hereditary deficiency of hypoxanthine-guanine phosphoribosyl- transferase (HGPRT) such as Lesch-Nyhan and Kelley-Seegmiller syndrome.
Stoga treba izbjegavati njegovu primjenu kod bolesnika s rijetkim nasljednim nedostatkom hipoksantin gvanin fosforibozil transferaze (HGPRT) poput Lesch-Nyhanova i Kelley-Seegmillerova sindroma.
Therefore, it should not be used in patients with baseline haemoglobin > 13 g/dl.
Stoga se Retacrit ne smije koristiti kod bolesnika s početnom razinom hemoglobina >13 g/dl.
Therefore, its RF emissions are very low and are not likely to cause any interference in nearby electronic equipment.
Zbog toga su njegove RF emisije vrlo malene i nije vjerojatno da će uzrokovati smetnje na obližnjoj elektroničkoj opremi.
Therefore, its use in paediatric patients is not recommended due to a lack of data on safety and efficacy.
Ne preporučuje se primjena Tasigne u pedijatrijskih bolesnika zbog nedostatnih podataka o sigurnosti primjene i djelotvornosti.
Therefore, its use in this age group is not relevant.
Stoga nema relevantne primjene lijeka Eylea u ovoj dobnoj skupini.
Therefore, ivacaftor should be administered with fat-containing food.
Stoga ivakaftor treba primjenjivati s hranom bogatom mastima.
Therefore, Jentadueto must be discontinued prior to, or at the time of the test and not reinstituted until 48 hours afterwards, and only after renal function has been re-evaluated and has not deteriorated further (see section 4.4).
Stoga je potrebno prekinuti primjenu Jentadueta prije ili za vrijeme ispitivanja i ne smije se ponovno pokrenuti do 48 sati nakon toga i to samo kada se funkcija bubrega ponovno ocijeni te se nije dodatno pogoršala (vidjeti dio 4.4).
Therefore, keep injection syringes and needles as well.
Stoga uvijek uza se imajte i štrcaljke i igle za injekciju.
Therefore, keep injection syringes and needles as well.
Stoga uvijek uza se imajte štrcaljke i igle.
Therefore, known strong inducers of this isozyme (e.g. phenytoin, rifampicin, rifapentine, carbamazepine, nevirapine, phenobarbital, and St John’s Wort) are not recommended with olaparib, as it is possible that the efficacy of olaparib could be substantially reduced (see section 4.4).
Stoga se ne preporučuje istodobna primjena olapariba i poznatih snažnih induktora ovog izoenzima (npr. fenitoina, rifampicina, rifapentina, karbamazepina, nevirapina, fenobarbitala i gospine trave), zbog mogućnosti da djelotvornost olapariba bude značajno smanjena (vidjeti dio 4.4)..
Therefore, Levodopa/Carbidopa/Entacapone Orion and iron preparations should be taken at least 2-3 hours apart (see section 4.8).
Stoga razmak između uzimanja Levodopa/Carbidopa/Entacapone Oriona i preparata željeza mora iznositi najmanje 2-3 sata (vidjeti dio 4.8).
Therefore, live vaccines should not be given concurrently with Ilaris unless the benefits clearly outweigh the risks (see section 4.5).
Stoga se živa cjepiva ne smiju davati istodobno s Ilarisom, osim ako koristi očigledno ne premašuju rizike (vidjeti dio 4.5).
Therefore, live vaccines should not be given concurrently with Ilaris unless the benefits clearly outweigh the risks.
Stoga se živa cjepiva ne smiju davati istodobno s Ilarisom osim ako je jasno da koristi premašuju rizike.
Therefore, liver function tests are recommended for all patients prior to initiating ivacaftor, every 3 months during the first year of treatment and annually thereafter.
Stoga se u svih bolesnika preporučuju pretrage funkcije jetre prije početka liječenja lijekom Kalydeco, svaka 3 mjeseca u prvoj godini liječenja i jedanput godišnje nakon toga.
Therefore, long-acting beta2-adrenergic agonists such as Hirobriz Breezhaler should be used with caution in patients with known or suspected prolongation of the QT interval or treated with medicinal products affecting the QT interval.
Stoga, dugodjelujuće beta2-adrenergičke agoniste kao što je Hirobriz Breezhaler treba oprezno koristiti u bolesnika s poznatim ili suspektnim produljenjem QT intervala ili u onih koji se liječe lijekom koji utječe na QT interval.
Therefore, long-acting beta2-adrenergic agonists such as Onbrez Breezhaler should be used with caution in patients with known or suspected prolongation of the QT interval or treated with medicinal products affecting the QT interval.
Stoga, dugodjelujuće beta2-adrenergičke agoniste kao što je Onbrez Breezhaler treba oprezno koristiti u bolesnika s poznatim ili suspektnim produljenjem QT intervala ili u onih koji se liječe lijekom koji utječe na QT interval.
Therefore, long-acting beta2-adrenergic agonists such as Oslif Breezhaler should be used with caution in patients with known or suspected prolongation of the QT interval or treated with medicinal products affecting the QT interval.
Stoga, dugodjelujuće beta2-adrenergičke agoniste kao što je Oslif Breezhaler treba oprezno koristiti u bolesnika s poznatim ili suspektnim produljenjem QT intervala ili u onih koji se liječe lijekom koji utječe na QT interval.
Therefore, lumacaftor/ivacaftor should be used with caution at a maximum dose of one tablet in the morning and one tablet in the evening (lumacaftor 400 mg/ivacaftor 250 mg total daily dose), or less, in patients with severe hepatic impairment after weighing the risks and benefits of treatment (see sections 4.2, 4.4, and 4.8).
Stoga u bolesnika s teškim oštećenjem funkcije jetre lumakaftor/ivakaftor se mora primjenjivati oprezno, u maksimalnoj dozi od jedne tablete ujutro i jedne tablete navečer (ukupna dnevna doza je 400 mg lumakaftora/250 mg ivakaftora) ili manjoj, nakon procjene rizika i koristi od liječenja (vidjeti dijelove 4.2, 4.4 i 4.8).
Therefore, Lutetium metal- ion toxicity of EndolucinBeta (177Lu)-labelled medicinal products can be excluded.
Stoga se toksičnost lijekova označenih lutecijem (177Lu) s pomoću EndolucinBete, s obzirom na lutecijev metalni ion, može isključiti.
Therefore, Lynparza is not recommended for use in patients with hepatic impairment (serum bilirubin greater than 1.5 times upper limit of normal), as safety and efficacy have not been established.
Stoga se ne preporučuje primjena lijeka Lynparza kod bolesnica s oštećenjem jetrene funkcije (vrijednost bilirubina u serumu više od 1,5 puta iznad gornje granice normale) jer nisu ustanovljene sigurnost i djelotvornost.
Therefore, maintaining lamivudine therapy despite emergence of M184V mutation should only be considered in cases where no other active NRTI’s are available.
Stoga se nastavak liječenja lamivudinom, unatoč pojavi M184V mutacija, treba razmotriti samo u slučajevima kada nisu dostupni drugi aktivni inhibitori nukleozidne reverzne transkriptaze.
Therefore, maraviroc can be taken with or without food at the recommended doses (see section 4.2).
Zbog toga se u preporučenim dozama maravirok može uzimati bez jela ili uz jelo (vidjeti dio 4.2).
Therefore, measurements of APTT and ACT are unsuitable and unreliable for monitoring enoxaparin sodium activity.
Stoga mjerenje APTT i ACT nije prikladno i nije pouzdano za praćenje aktivnosti enoksaparin-natrija.
Therefore, measurements of APTT and ACT are unsuitable and unreliable for monitoring enoxaparin sodium activity.
Stoga mjerenje APTT i ACT nije prikladno i nije pouzdano za praćenje aktivnosti enoksaparinnatrija.
Therefore, measurements of APTT and ACT are unsuitable and unreliable for monitoring enoxaparin sodium activity.
Stoga mjerenje APTT i ACTnije prikladno i nije pouzdano za praćenje aktivnosti enoksaparinnatrija.
Therefore, medicinal products metabolised by CYP1A2 (such as duloxetin, alosetron, theophylline and tizanidine) should be used with caution during treatment with teriflunomide, as it could lead to the reduction of the efficacy of these products.
Stoga se lijekovi koji se metaboliziraju putem CYP1A2 (poput duloksetina, alosetrona, teofilina i tizanidina) moraju primjenjivati uz oprez tijekom liječenja teriflunomidom, jer on može smanjiti njihovu djelotvornost.
Therefore, medicinal products metabolised by CYP1A2 (such as duloxetine, alosetron, theophylline and tizanidine) should be used with caution during treatment, as it could lead to the reduction ofthe efficacy of these products.
Stoga se lijekovi koji se metaboliziraju uz CYP1A2 (kao što su duloksetin, alosetron, teofilin i tizanidin) moraju oprezno koristiti tijekom liječenja leflunomidom, budući da može doći do smanjenja djelotvornosti ovih lijekova.
Therefore, medicinal products that are inhibitors of this active renal elimination pathway or are eliminated by this pathway, such as cimetidine, amantadine mexiletine, zidovudine, cisplatin, quinine, and procainamide may interact with pramipexole resulting in reduced clearance of pramipexole.
Stoga, lijekovi koji su inhibitori tog aktivnog renalnog puta eliminacije ili se tim putem odstranjuju, kao što su cimetidin, amantidin i meksiletin, zidovudin, cisplatin, kinin i prokainamid, mogu stupiti u interakciju s pramipeksolom, što može rezultirati smanjenim klirensom pramipeksola.
Therefore, medicinal products that are inhibitors of this active renal elimination pathway or are eliminated by this pathway, such as cimetidine,amantadine mexiletine, zidovudine, cisplatin, quinine, and procainamide, may interact with pramipexole resulting in reduced clearance of pramipexole.
Stoga lijekovi koji su inhibitori tog aktivnog renalnog puta eliminacije ili se tim putem odstranjuju, kao što su cimetidin, amantadin, meksiletin, zidovudin, cisplatin, kinin i prokainamid, mogu stupiti u interakciju s pramipeksolom, što može rezultirati smanjenim klirensom pramipeksola.
Therefore, medicinal products that either share this metabolic pathway or modify CYP3A4 and/or P-gp activity “see "Other potential interactions") may modify the pharmacokinetics of saquinavir.
Stoga lijekovi koji dijele taj metabolički put ili modificiraju djelovanje CYP3A4 i/ili P-glikoproteina (vidjeti "Druge moguće interakcije") mogu promijeniti farmakokinetiku sakvinavira.
Therefore, men being treated with it should be advised not to father a child up to 6 months after receiving the last dose and to seek advice on cryoconservation of sperm prior to treatment, because of the possibility of irreversible infertility due to therapy with TMZ.
Stoga, muškarcima koji se liječe ovim lijekom treba savjetovati da ne začinju dijete do 6 mjeseci nakon primanja posljednje doze lijeka te da se prije početka liječenja posavjetuju oko kriokonzervacija sperme, jer postoji mogućnost da terapija TMZ-om dovede do trajne neplodnosti.
Therefore, men being treated with it should be advised not to father a child up to 6 months after receiving the last dose and to seek advice on cryoconservation of sperm prior to treatment, because of the possibility of irreversible infertility due to therapy with TMZ.
Stoga, muškarcima koji se liječe ovim lijekom treba savjetovati da ne začinju dijete do 6 mjeseci nakon primanja posljednje doze lijeka te da se prije početka liječenja posavjetuju oko pohrane sperme zamrzavanjem, jer postoji mogućnost da terapije TMZ-om dovede do trajne neplodnosti.
Therefore, men being treated with it should be advised not to father a child up to 6 months after receiving the last dose and to seek advice on cryoconservation of sperm prior to treatment. because of the possibility of irreversible infertility due to therapy with TMZ.
Stoga, muškarcima koji se liječe ovim lijekom treba savjetovati da ne začinju dijete do 6 mjeseci nakon primanja posljednje doze lijeka te da se prije početka liječenja posavjetuju oko pohrane sperme zamrzavanjem jer postoji mogućnost da terapija TMZ-om dovede do trajne neplodnosti.
Therefore, MEPACT should not be used during pregnancy and in women not using effective contraception.
Stoga se MEPACT ne smije koristiti u trudnoći i kod žena koje ne koriste učinkovitu kontracepciju.
Therefore, mild increases in creatinine observed after long-term treatment with naltrexone / bupropion are likely due to inhibition of OCT2 and not indicative of changes in creatinine clearance.
Dakle, blaga povećanja kreatinina uočena nakon dugotrajnog liječenja s naltrekson / bupropionom su vjerojatno posljedica inhibicije OCT2 i ne ukazuje na promjene u klirensu kreatinina.
Therefore, monitoring of temperature and measures to lower the fever (such as antipyretic medication as seems clinically necessary) are recommended in young children (e.g. up to approximately 6 years of age) after each dose of Pandemrix.
Stoga se nakon svake doze cjepiva Pandemrix u male djece (npr. do oko 6 godina starosti) preporučuje praćenje tjelesne temperature i provođenje mjera snižavanja vrućice (poput davanja antipiretika ako to bude klinički nužno).
Therefore, monitoring of the INR during co-administration with warfarin is recommended.
Stoga se preporučuje praćenje INR-a tijekom istovremene primjene s varfarinom.
Therefore, no adjustment is necessary for oral dosing for patients with mild to severe renal impairment (see section 5.2).
Stoga nije potrebno prilagođavati dozu nakon peroralne primjene vorikonazola u bolesnika s umjerenim do teškim oštećenjem bubrega (vidjeti dio 5.2).
Therefore, no dosage adjustment is recommended for patients with hepatic impairment.
Stoga se ne preporučuje prilagodba doziranja u bolesnika s oštećenjem fukcije jetre.
Therefore, no dose adjustment for lumacaftor/ivacaftor are recommended for mild or moderate renal impairment.
Stoga se ne preporučuje prilagodba doze lumakaftora/ivakaftora kod blagog ili umjerenog oštećenja funkcije bubrega.
Therefore, no dose adjustment is necessary for patients with mild hepatic impairment.
Stoga nije potrebna prilagodba doze u bolesnika s blagim oštećenjem funkcije jetre.
Therefore, no dose adjustment is necessary for patients with mild hepatic impairment.
Stoga u bolesnika s blagim oštećenjem funkcije jetre nije potrebna prilagodba doze.
Therefore, no dose adjustment is recommended for INCIVO in HCV patients with renal impairment.
Stoga se u bolesnika s HCV-om i oštećenjem funkcije bubrega ne preporučuje prilagodba doze INCIVA.
Therefore, no dose adjustment of alogliptin is necessary for patients with mild to moderate hepatic impairment (Child-Pugh scores of to 9).
Stoga u bolesnika s blagim do umjerenim oštećenjem jetre (Child-Pugh indeks 5 do 9) nije potrebna prilagodba doze.
Therefore, no dose adjustment of ribavirin is required in patients with hepatic impairment.
Stoga nije potrebno prilagođavati dozu ribavirina u bolesnika s oštećenjem jetrene funkcije.
Therefore, no dose adjustments are recommended for mild and moderate renal impairment.
Stoga se ne preporučuje prilagodba doze kod blagog i umjerenog oštećenja funkcije bubrega.
Therefore, no dose recommendations can be made.
Stoga nije moguće dati preporuku doze.
Therefore, no increase in exposure of CYP3A4 substrates is anticipated when combining them with Jakavi.
Stoga se ne očekuje povećana izloženost CYP3A4 supstratima kada se kombiniraju s Jakavijem.
Therefore, no initial dose adjustment is necessary for patients with renal impairment.
Stoga, nije potrebna prilagodba početne doze u bolesnika s oštećenjem bubrega.
Therefore, no pharmacokinetic interaction is expected with drugs known to be metabolised by these enzyme systems.
Stoga se ne očekuje farmakokinetička interakcija s lijekovima za koje se zna da ih metaboliziraju spomenuti enzimski sustavi.
Therefore, no precautions are necessary when safinamide is taken with medicinal products that are BCRP substrates (e.g., pitavastatin, pravastatin, ciprofloxacin, methotrexate, topotecan, diclofenac or glyburide).
Stoga, nisu potrebne nikakve mjere predostrožnosti kada se safinamid uzima s lijekovima koji su BCRP supstrati (npr., pitavastatin, pravastatin, ciprofloksacin, metotreksat, topotekan, diklofenak ili gliburid).
Therefore, no tenofovir disoproxil fumarate dose adjustment is required in patients with hepatic impairment.
Stoga, nije potrebna prilagodba doze tenofovirdizoproksilfumaratau pacijenata s oštećenjem funkcije jetre.
Therefore, no valid figures on the incidence of clinically relevant specific inhibitors are currently available.
Stoga trenutačno nisu dostupni valjani podaci o incidenciji klinički relevantnih specifičnih inhibitora.
Therefore, olaparib upon co-administration may reduce the exposure to substrates of these metabolic enzymes and transport protein.
Stoga, istodobna primjena olapariba mogla bi smanjiti izloženost supstratima tih metaboličkih enzima i prijenosnog proteina.
Therefore, Optimark must not be used in patients who have had or are undergoing liver transplantation and in neonates (see section 4.3).
Zbog toga se Optimark ne smije davati bolesnicima kod kojih je transplantirana jetra, odnosno bolesnicima koji će biti podvrgnuti transplantaciji jetre i novorođenčadi (vidjeti dio 4.3).
Therefore, ORENCIA solution for injection is not recommended for use in this patient population.
Stoga se ne preporučuje primjena lijeka ORENCIA otopina za injekciju u ovoj populaciji bolesnika.
Therefore, Orkambi should not be used in children under the age of 12 years.
Stoga se Orkambi ne smije primjenjivati u djece mlađe od 12 godina.
Therefore, other intravenous substances, additives or other medicinal products mixed in sodium chloride solution should not be added to oritavancin single- use vials or infused simultaneously through the same intravenous line or through a common intravenous port.
Stoga se druge intravenske tvari, aditivi ili drugi lijekovi miješani u otopini natrijevog klorida ne smiju dodavati u jednodozne bočice oritavancina niti primjenjivati istovremeno infuzijom kroz istu intravensku liniju ili kroz zajednički intravenski ulaz.
Therefore, P-gp inhibitors may increase tissue levels more than plasma levels.
Zbog toga P-gp inhibitori mogu povećati razine u tkivima više nego razine u plazmi.
Therefore, P-gp inhibitors may increase tissue levels more than plasma levels.
Zbog toga P-gp inhibitori mogu povećati razine u tkivma više nego razine u plazmi.
Therefore, particular caution is required if Eurartesim is administered to patients taking potent CYP3A4 inhibitors (e.g. some protease inhibitors amprenavir, atazanavir, indinavir, nelfinavir, ritonavir], nefazodone or verapamil), and ECG monitoring should be considered due to the risk of higher plasma concentrations of piperaquine (see section 4.4).
Stoga je potreban poseban oprez ako se Eurartesim primjenjuje bolesnicima koji uzimaju jake inhibitore CYP3A4 (npr. neki inhibitori proteaze amprenavir, atazanavir, indinavir, nelfinavir, ritonavir], nefazodon ili verapamil) i potrebno je razmotriti EKG nadzor zbog rizika od povišenih koncentracija piperakina u plazmi (vidjeti dio 4.4).
Therefore, patients experiencing allergic reactions should be evaluated for the presence of an inhibitor.
Stoga je u pacijenata koji su imali alergijske reakcije potrebno utvrditi prisutnost inhibitora.
Therefore, patients experiencing an anaphylactic reaction should be evaluated for the presence of an inhibitor.
Stoga bolesnike koji imaju anafilaktične reakcije treba pregledati na prisutnost inhibitora.
Therefore, patients hoping to achieve conception should either avoid using Fortacin, or, if this medicine is essential to achieve penetration, should wash the penis as thoroughly as possible five minutes after Fortacin has been applied, but prior to intercourse.
Stoga, bolesnici koji nastoje postići oplodnju trebaju izbjegavati Fortacin, ili, ako je on nužan za postizanje penetracije, trebaju oprati glavić penisa što je temeljitije moguće pet minuta nakon što su nanijeli Fortacin, ali prije snošaja.
Therefore, patients may need a reduction in the dose of ESAs.
Stoga, bolesnicima može biti potrebno smanjenje doze LSE .
Therefore, patients may need reduction in, or discontinuation of, intravenous iron and/or ESAs.
Stoga, bolesnicima može biti potrebno smanjenje ili prekid primjene intravenskog željeza i/ili LSE.
Therefore, patients must be cautious when driving or using machines (see section 4.8).
Stoga bolesnici moraju biti oprezni kad upravljaju vozilima ili rade sa strojevima (vidjeti dio 4.8).
Therefore, patients must be monitored carefully when the dose of levodopa/carbidopa is reduced abruptly or discontinued, especially if the patient is receiving antipsychotics (see section 4.2).
Stoga bolesnike treba pažljivo pratiti kada se doza levodope/karbidope naglo smanjuje ili prekida, naročito ako bolesnik prima antipsihotike (vidjeti dio 4.2).
Therefore, patients receiving oral anticoagulants should be closely monitored for their prothrombin time INR, particularly in the first few days when therapy with parecoxib is initiated or the dose of parecoxib is changed (see section 4.4).
Stoga se u bolesnika koji uzimaju oralne antikoagulanse mora pažljivo nadzirati protrombinsko vrijeme INR, osobito tijekom prvih nekoliko dana terapije parekoksibom ili nakon promjene doze parekoksiba (vidjeti dio 4.4).
Therefore, patients should be advised not to drive or operate machines until their individual susceptibility to this medicinal product is known.
Stoga bolesnicima treba savjetovati da ne upravljaju vozilima i strojevima sve dok se ne sazna koliko su podložni takvom utjecaju.
Therefore, patients should be advised not to open the capsules and taking the pellets alone (e.g. sprinkled over food or into beverages) (see section 4.2).
Stoga je potrebno savjetovati bolesnicima da ne otvaraju kapsule i ne uzimaju same pelete (npr. raspršene po hrani ili piću) (vidjeti dio 4.2).
Therefore, patients should be advised that their physical and/ or mental abilities needed for operating machinery or driving may be impaired and they are recommended not to do so until it has been established that their ability to perform such activities is not affected.
Stoga bolesnike treba savjetovati da im fizičke i/ili mentalne sposobnosti za upravljanje strojevima ili vožnju mogu biti smanjene i ne preporučuje im se upravljati strojevima ili vozilima dok se ne utvrdi da njihova sposobnost za obavljanje takvih aktivnosti nije ograničena.
Therefore, patients should be monitored carefully for the appearance of rash during this period.
Stoga, bolesnici moraju biti pomno praćeni zbog pojave osipa tijekom tog perioda.
Therefore, patients should be monitored for opiate withdrawal syndrome.
Potrebno je pratiti bolesnike radi
Therefore, patients should be monitored for signs of depression and/or suicidal ideation and behaviours and appropriate treatment should be considered.
Stoga sekod bolesnika moraju pratiti znakovi depresije i/ili samoubilačke ideje i ponašanje te razmotriti prikladan oblik liječenja.
Therefore, patients should be monitored for signs of suicidal ideation and behaviours and appropriate treatment should be considered.
Stoga ove bolesnike treba nadzirati u smislu pojave znakova suicidalne ideacije i suicidalnog ponašanja te razmotriti potrebu uvođenja odgovarajuće terapije.
Therefore, patients should have access to water and be able to drink sufficient amounts of water.
Stoga bi bolesnici trebali imati pristup vodi i piti dovoljne količine vode.
Therefore, patients should have periodic thyroid function tests and should be treated with thyroid hormone when indicated.
Stoga bolesnicima treba periodično kontrolirati funkciju štitne žlijezde i te ih prema potrebi liječiti tiroidnim hormonima.
Therefore, patients should remain under close clinical observation by physicians experienced in the treatment of these associated HIV diseases.
Stoga te bolesnike mora pažljivo nadzirati liječnik koji ima iskustva u liječenju bolesti povezanih s HIV infekcijom.
Therefore, patients treated with glucocorticoids should have their growth monitored carefully to assess the potential impact of glucocorticoid treatment on growth.
Stoga je u bolesnika liječenih glukokortikoidima potrebno pažljivo pratiti rast kako bi se procijenio mogući učinak liječenja glukokortikoidima na rast.