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Telaprevir
HCV-a.
Telaprevir
Maravirok
telaprevir
↔telaprevir
Telaprevir (750 mg every
Telaprevir (750 mg na svakih
Telaprevir (750 mg three times
Telaprevir (750 mg tri puta na
Telaprevir (750 mg three times daily)/
Telaprevir (750 mg tri puta na dan)/
Telaprevir (750 mg three times daily)/ Elvitegravir (150 mg once daily)/ Cobicistat (150 mg once daily)4
Telaprevir (750 mg triput na dan)/ elvitegravir (150 mg jedanput na dan)/kobicistat (150 mg jedanput na dan)4
Telaprevir (relative to 750 mg q8h):
telaprevir (u odnosu na 750 mg svakih 8h)
Telaprevir 500 mg q12h (daclatasvir 20 mg once daily)
(daklatazvir 20 mg jedanput na dan)
Telaprevir 750 mg three times
Telaprevir 750 mg triput na dan
Telaprevir 750 mg three times daily (atazanavir/ritonavir 300/100 mg once daily)
Telaprevir 750 mg triput na dan
telaprevir and boceprevir
telaprevir i boceprevir
telaprevir AUC ↓ 5% telaprevir Cmin ↓ 11% telaprevir Cmax ↓ 3% rilpivirine AUC ↑ 78% rilpivirine Cmin ↑ 93% rilpivirine Cmax ↑ 49%
telaprevir AUC ↓ 5% telaprevir Cmin ↓ 11% telaprevir Cmax ↓ 3% rilpivirin AUC ↑ 78% rilpivirin Cmin ↑ 93% rilpivirin Cmax ↑ 49
Telaprevir binds primarily to alpha 1-acid glycoprotein and albumin.
Telaprevir se primarno veže za alfa 1-kiseli glikoprotein i albumin.
Telaprevir can be administered orally with food as 375 mg tablets, 1,125 mg twice daily (b.i.d.) for 12 weeks, in combination with peginterferon alfa and ribavirin.
Telaprevir se može primjeniti peroralno uz obrok u obliku tableta od 375 mg, u dozi od 1125 mg dva puta na dan (b.i.d.) tijekom 12 tjedana, u kombinaciji s peginterferonom alfa i ribavirinom.
Telaprevir concentrations
Istodobna primjena
Telaprevir is an inhibitor of the HCV NS3•4A serine protease, which is essential for viral replication.
Telaprevir je inhibitor HCV NS3•4A serinske proteaze, koja je neophodna za replikaciju virusa.
telaprevir is contraindicated (see section 4.3).
telaprevirom je kontraindicirana (vidjeti
Telaprevir is metabolized in the liver by CYP3A and is a P- glycoprotein (P-gp) substrate, but other enzymes may be involved in the metabolism.
Telaprevir se metabolizira u jetri putem CYP3A te je supstrat P- glikoproteina (P-gp), ali i drugi enzimi mogu biti uključeni u njegov metabolizam.
Telaprevir  (historical controls) (inhibition of CYP3A enzyme)
(kontrole iz prethodnih ispitivanja) (inhibicija enzima CYP3A)
Telaprevir 
Amprenavir: AUC12  0,65
telaprevir.
telaprevirom.
Telaprevir/Efavirenz (1,125 mg q8h/600 mg once daily)
azitromicin/efavirenz (600 mg jednokratna doza/400 mg jedanput na dan)
Telaprevir/Efavirenz (1,125 mg q8h/600 mg once daily)
Telaprevir/Efavirenz (1.125 mg q8h/600 mg jedanput na dan)
Telaprevir/Efavirenz (1,125 mg q8h/600 mg q.d.)
telaprevir/efavirenz (1125 mg q8h/600 mg q.d.)
Telavancin also binds to bacterial membranes and causes depolarisation of membrane potential and an increase in membrane permeability that results in inhibition of protein, RNA, and lipid synthesis.
Telavancin se također veže na bakterijske membrane i uzrokuje depolarizaciju membranskog potencijala i povećanje propusnosti membrane što dovodi do inhibicije sinteze proteina, RNK i lipida.
Telavancin dose (mg) = 10 mg/kg (or 7.5 mg/kg) x patient body weight (in kg) Volume of reconstituted concentrate (ml) = Telavancin dose (mg)/15 (mg/ml) Incompatibilities
Doza telavancina (mg) = 10 mg/kg (ili 7,5 mg/kg) x tjelesna težina bolesnika (u kg) Volumen rekonstituiranog koncentrata (ml) = Doza telavancina (mg)/15 (mg/ml) Inkompatibilnosti
Telbivudine 600 mg (n = 199)1
Telbivudin 600 mg (n = 199)1
Telbivudine 600 mg (n = 384)1
Telbivudin 600 mg (n = 384)1
Telbivudine is not a substrate, inducer or inhibitor of the cytochrome P450 (CYP450) enzyme
Telbivudin nije supstrat, induktor niti inhibitor enzimskog sustava citokroma P450 (CYP450).
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Telithromycin
Eritromicin
Telithromycin
telitromicin
telithromycin are initiated in patients
istodobno s eritromicinom.
Telithromycin displays a tri-exponential decay from plasma, with a rapid distribution half-life of 0.17 h.
Nestajanje telitromicina iz plazme odvija se eksponencijalno u tri faze, s kratkim poluvremenom distribucije od 0,17 h.
Telithromycin does not induce expression of macrolide-lincosamide-streptogramin B (MLSB)- mediated resistance in vitro in Staphylococcus aureus, Streptococcus pneumoniae, or Streptococcus pyogenes.
Telitromicin in vitro ne inducira ekspresiju rezistencije na makrolide, linkozamide i streptogramin B (MLSB-tip rezistencije) u mikroorganizmima Staphylococcus aureus, Streptococcus pneumoniae i Streptococcus pyogenes.
Telithromycin has been shown to decrease the Cmax by 34 % and AUC of sotalol by 20 % due to decreased absorption.
Pokazalo se da telitromicin smanjuje Cmax sotalola za 34% i bioraspoloživost (AUC) za 20% zbog smanjene apsorpcije.
Telithromycin is a semisynthetic derivative of erythromycin A belonging to the ketolides, a class of antibacterial agents related to macrolides.
Telitromicin je polusintetski derivat eritromicina A iz skupine ketolida, antibiotika srodnih makrolidima.
Telithromycin is an inhibitor of CYP3A4 and CYP2D6, but has no or limited effect on CYP1A, 2A6, 2B6, 2C8, 2C9, 2C19 and 2E1.
Telitromicin je inhibitor CYP3A4 i CYP2D6, ali nema učinka ili mu je učinak slab prema CYP1A, 2A6, 2B6, 2C8, 2C9, 2C19 i 2E1.
Telithromycin, clarithromycin
Telitromicin, klaritromicin
telithromycin, clarithromycin, erythromycin (for bacterial infections) indinavir, nelfinavir, saquinavir (for HIV infection)
telitromicin, klaritromicin, eritromicin (protiv bakterijskih infekcija) indinavir, nelfinavir, sakvinavir (protiv infekcije HIV-a)
telithromycin, clarithromycin, erythromycin - used for bacterial infections protease inhibitors boosted with ritonavir or cobicistat, boceprevir, telaprevir, nevirapine, efavirenz - used for viral infections, including HIV rifampicin, rifapentine, rifabutin - used for bacterial infections, including tuberculosis (TB) phenytoin, carbamazepine, phenobarbital - used as a sedative or to treat fits (seizures) and epilepsy
telitromicin, klaritromicin, eritromicin - koriste se za liječenje bakterijskih infekcija inhibitore proteaze pojačane ritonavirom ili kobicistatom, boceprevir, telaprevir, nevirapin, efavirenz - koriste se za liječenje virusnih infekcija, uključujući HIV rifampicin, rifapentin, rifabutin - koriste se za liječenje bakterijskih infekcija, uključujući tuberkulozu (TBC)
Telithromycin, clarithromycin, erythromycin, rifampicin, rifabutin, antibiotic medicines used for the treatment of bacterial infections
telitromicin, klaritromicin, eritromicin, rifampicin, rifabutin, antibiotike koji se primjenjuju za liječenje bakterijskih infekcija
telithromycin, erythromycin, or clarithromycin (antibiotics for infections),
telitromicin, eritromicin ili klaritromicin (antibiotike za liječenje infekcija),
telithromycin, which may reduce their
izloženost eritromicinu, što može oslabiti
Tell a doctor if any of these become troublesome.
Obavijestite svog liječnika ukoliko Vam bilo koja od njih stvara poteškoće.
Tell a doctor if any of these become troublesome.
Recite svom liječniku ukoliko Vam bilo koja od njih stvara poteškoće.
Tell a doctor if any of these becomes troublesome.
Ako Vam ijedna od navedenih nuspojava stvara probleme, obratite se liječniku.
Tell a doctor or a nurse straight away if you experience symptoms suggestive of allergic reaction, such as wheezing, difficulty breathing, swelling of the face, neck and throat, rashes and hives, fever (see section 4 of this leaflet for more information).
Odmah obavijestite liječnika ili medicinsku sestru ukoliko Vam se pojave simptomi koji upućuju na alergijsku reakciju, poput piskanja, otežanog disanja, oteknuća lica, vrata ili grla, osipa i koprivnjače, vrućice (za više podataka vidjeti dio 4 ove upute).
Tell a doctor or nurse straight away, if you notice any of the following side effects:
Odmah obavijestite liječnika ili medicinsku sestru ako opazite neku od sljedećih nuspojava:
Tell a doctor or pharmacist if you are worried about any of these.
Obavijestite svog liječnika ili ljekarnika ako Vas nešto od toga zabrinjava.
Tell a doctor or pharmacist if you are worried about this.
Obavijestite svog liječnika ili ljekarnika ako Vas to zabrinjava.
Tell a doctor straight away if you notice any of the following side effects: Very common (may affect more than 1 in 10 people) fever, chills, body aches, feeling tired, cold or flu symptoms, being short of breath – these could be signs of an infection (viral, bacterial or fungal).
Odmah recite liječniku ako primijetite bilo koju od sljedećih nuspojava: Vrlo često (mogu se javiti u više od 1 na 10 osoba) vrućica, zimica, bol u tijelu, osjećaj umora, simptomi prehlade ili gripe, nedostatak zraka,– ovo mogu biti znakovi infekcije (virusne, bakterijske ili gljivične).
Tell a doctor straight away if you notice signs of severe allergic reactions.
Odmah se javite liječniku ukoliko primijetite znakove teških alergijskih reakcija.
Tell a doctor straight away if: you are sick (vomit), which is a common side effect, more than once and this does not stop.
Odmah recite liječniku ako: povraćate, što je česta nuspojava, više od jednom i to ne prestaje.
Tell a nurse or doctor or go to hospital straight away if you notice any of the following side effects:
Obavijestite medicinsku sestru ili liječnika, ili odmah otiđite u bolnicu ako primijetite neku od sljedećih nuspojava:
Tell also your doctor if you have any problem with your spine or if you have ever had spinal surgery.
Također ga obavijestite u slučaju da imate bilo kakvih problema s kralježnicom ili ste nekad imali operaciju na kralježnici.
Tell the doctor if you are taking hormonal/oral contraceptives.
Obavijestite liječnika ako uzimate hormonsku/oralnu kontracepciju.
Tell the doctor if you are taking the blood thinner – warfarin.
Obavijestite liječnika ako uzimate lijek za razrjeđivanje krvi – varfarin.
Tell the doctor if you or someone else in your family has a history of blood clots, as medicines like these have been associated with formation of blood clots.
Obavijestite svog liječnika ako ste Vi ili netko drugi u Vašoj obitelji ranije imali krvne ugruške, jer su lijekovi poput ovih povezani sa stvaranjem krvnih ugrušaka.
Tell the doctor if you or someone else in your family has a history of blood clots, as medicines like these have been associated with the formation of blood clots.
Obavijestite svog liječnika ako ste Vi ili netko drugi u Vašoj obitelji ranije imali krvne ugruške, jer su lijekovi poput ovih povezani sa stvaranjem krvnih ugrušaka.
Tell the doctor if you or someone else in your family has a history of blood clots, as medicines like these have been associated with the formation of blood clots.
Obavijestite svog liječnika ako ste Vi ili netko drugi u Vašoj obitelji u prošlosti imali krvne ugruške, budući da su lijekovi poput ovih povezani sa stvaranjem krvnih ugrušaka.
Tell the doctor if you or the child is taking these medicines since the treatment must be modified before you or the child start taking EMEND.
Recite liječniku ako Vi ili dijete uzimate ove lijekove jer će morati prilagoditi liječenje prije nego Vi ili dijete počnete uzimati EMEND.
Tell the doctor if you or the child is taking these medicines since the treatment must be modified before you or the child start taking EMEND.
Recite liječniku ako Vi ili dijete uzimate ove lijekove jer će morati prilagoditi terapiju prije nego Vi ili dijete počnete uzimati EMEND.
Tell the doctor or nurse if you feel dizzy or faint after the injection.
Obavijestite liječnika ili medicinsku sestru ako nakon injekcije osjećate omaglicu ili nesvjesticu.
Tell the doctor or nurse if you feel dizzy or faint after the injection.
Obavijestite svog liječnika ili medicinsku sestru ako osjetite omaglicu ili nesvjesticu nakon injekcije.
Tell the doctor or pharmacist if the child is taking, has recently taken or might take any other medicines (including anakinra, abatacept or sulfasalazine), even those not prescribed by the child's doctor.
Obavijestite svog liječnika ili ljekarnika ako Vi ili dijete uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove (uključujući anakinru, abatacept ili sulfasalazin), čak i one koje nije propisao liječnik.
Tell the doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Obavijestite svog liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući one koje ste nabavili bez recepta.
Tell the doctor requesting these tests that you have recently been given Celvapan. you have a bleeding condition or a bleeding problem or you bruise easily.
Recite liječniku koji traži te pretrage da ste nedavno primili Celvapan. ako imate problema s krvarenjem ili lako dobijete modrice.
Tell the doctor requesting these tests that you have recently been given Pandemrix. if you have a bleeding problem or bruise easily.
Obavijestite liječnika koji je zatražio te pretrage da ste nedavno primili Pandemrix. ako imate problema s krvarenjem ili lako dobivate modrice.
Tell the doctor requesting these tests that you have recently been given Prepandemic Influenza vaccine (H5N1) (surface antigen, inactivated, adjuvanted) Novartis Vaccines and Diagnostics.
Recite liječniku koji zatraži te pretrage da ste nedavno primili Prepandemijsko cjepivo protiv influence (H5N1) (površinski antigen, inaktivirano, adjuvantirano) Novartis Vaccines and Diagnostics.
Tell the doctor requesting these tests that you have recently been given Pumarix. if you have a bleeding problem or you bruise easily.
Obavijestite liječnika koji je zatražio navedena testiranja da ste nedavno primili Pumarix. imate li problema s krvarenjem ili lako dobivate modrice.
Tell the doctor requesting these tests that you have recently received Adjupanrix. you have a bleeding problem or you bruise easily.
Recite liječniku koji zahtijeva navedene pretrage da ste nedavno primili Adjupanrix. ako imate problema s krvarenjem ili lako dobivate modrice.
Tell the doctor requesting these tests that you have recently received PANDEMIC INFLUENZA VACCINE H5N1 BAXTER; if you have a bleeding problem or bruise easily.
Recite liječniku koji zatraži te testove da ste nedavno primili CJEPIVO PROTIV PANDEMIJSKE INFLUENCE H5N1 BAXTER; ako imate problema s krvarenjem ili lako dobijete modrice.
Tell the doctor requesting these tests that you have recently received Prepandrix. if you have a bleeding problem or you bruise easily.
Recite liječniku koji zahtijeva navedene pretrage da ste nedavno primili Prepandrix. ako imate problema s krvarenjem ili lako dobivate modrice.
Tell the doctor that you are taking Trobalt, well in advance.
Znatno unaprijed obavijestite svog liječnika da uzimate Trobalt.
Tell the doctor, pharmacist or nurse if you or the child notice any of the following side effects:
Obavijestite liječnika, ljekarnika ili medicinsku sestru ako Vi ili dijete primijetite bilo koju od sljedećih nuspojava:
Tell the person doing the test that you are using DARZALEX.
Obavijestite osobu koja provodi pretragu da primate DARZALEX.
Tell the your doctor that he/she is taking HEMANGIOL.
Recite svom liječniku da vaše dijete uzima HEMANGIOL.
Tell your anaesthetist if you are on a controlled salt diet.
Recite anesteziologu ako ste na dijeti s ograničenim unosom soli.
Tell your baby’s doctor if your newborn is taking, have recently taken or might take any other medicines.
Obavijestite liječnika Vašeg djeteta ako Vaše novorođenče prima, ako je nedavno primilo ili ako bi moglo primiti druge lijekove.
Tell your caregiver that you are taking Exelon.
Osobi koja brine o Vama recite da uzimate Exelon.
Tell your caregiver that you are taking Exelon.
Recite osobi koja Vas njeguje da uzimate Exelon.
Tell your caregiver that you are taking Nimvastid.
Recite osobi koja Vas njeguje da uzimate Nimvastid.
Tell your caregiver that you are taking Prometax.
Osobi koja brine o Vama recite da uzimate Prometax.
Tell your caregiver that you are taking Prometax.
Recite osobi koja Vas njeguje da uzimate Prometax.
Tell your caregiver that you are taking Rivastigmine 1 A Pharma.
Recite osobi koja Vas njeguje da uzimate Rivastigmin 1 A Pharma.