natgillin/translations-raw huggingface dataset:
Although the doses of prior antifungal therapies in patients enrolled as refractory were lower than those often administered for invasive aspergillosis, the favourable response rate during therapy with caspofungin was similar in these patients to that seen in the remaining refractory patients (2/5 versus 17/48, respectively).
Premda su doze prethodno primijenjenih antimikotika u 5 bolesnika s infekcijom otpornom na liječenje bile niže od onih često primjenjivanih za invazivnu aspergilozu, stopa povoljnih odgovora tijekom liječenja kaspofunginom u tih bolesnika bila je slična onoj u preostalih bolesnika s infekcijom otpornom na liječenje (2/5 naspram 17/48).
Although the duration of the protective effect of a previous formulation of Merck’s recombinant hepatitis B vaccine in healthy vaccinees is unknown, follow-up over 5-9 years of approximately 3,000 high-risk subjects given a similar plasma-derived vaccine has revealed no cases of clinically apparent hepatitis B infection.
Premda trajanje zaštitnog učinka prethodne formulacije Merckovog rekombinantnog cjepiva protiv hepatitisa B u zdravih cijepljenih osoba nije poznato, tijekom praćenja u trajanju od 5-9 godina približno 3000 osoba s visokim rizikom koje su primile slično cjepivo dobiveno iz plazme nije bilo slučajeva klinički vidljive infekcije hepatitisom B.
Although the effects shown were modest (resolution of VMA in a quarter of patients), they were considered to be significant as treatment may improve vision and prevent the need for surgery.
Iako je dokazano djelovanje bilo skromno (uklanjanje VMA u četvrtine bolesnika), zaključeno je da je djelovanje značajno budući da terapija može poboljšati vid i spriječiti potrebu za kirurškim zahvatom.
Although the effects were modest, the size of the benefit was considered clinically relevant given the normally poor prognosis in these patients.
Iako su učinci bili umjereni, razmjer koristi smatrao se klinički relevantnim uzimajući u obzir uobičajeno lošu prognozu u ovih bolesnika.
Although the efficacy profile of 90 mg and 60 mg were similar, there is evidence that the lower dose has a better tolerability and safety profile in relation to risk of the bleeding and dyspnoea.
Iako su profili djelotvornosti za doze od 90 mg i 60 mg bili slični, postoje dokazi da se niža doza bolje podnosi i ima bolji sigurnosni profil s obzirom na rizik od krvarenja i dispneje.
Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to combination anti-retroviral therapy.
Iako se smatra da ima više uzroka (uključujući primjenu kortikosteroida, konzumiranje alkohola, jaku imunosupresiju, povišen indeks tjelesne mase), slučajevi osteonekroze bili su prijavljeni posebice u bolesnika s uznapredovalom HIV bolešću i/ili u bolesnika izloženih dugotrajnoj kombiniranoj antiretrovirusnoj terapiji (engl. combination anti-retroviral therapy, CART).
Although the etiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to combination antiretroviral therapy (CART).
Iako se smatra da je etiologija ove bolesti multifaktorijalna (uključujući upotrebu kortikosteroida, korištenje alkohola, jaku imunosupresiju, viši indeks tjelesne mase) zabilježeni su slučajevi osteonekroze osobito u bolesnika koji imaju uznapredovalu HIV bolest i/ili su bili dugoročno izloženi kombiniranoj antiretrovirusnoj terapiji (CART).
Although the exact cause of PBA is unclear, it is believed that it affects the way signals are transmitted between brain cells by ‘neurotransmitters’, chemicals that allow nerve cells to communicate with each other.
Iako točan uzrok pseudobulbarnog afekta nije jasno utvrđen, vjeruje se da pseudobulbarni afekt utječe na način na koji „neurotransmiteri“, kemijske tvari koje omogućuju međusobnu komunikaciju živčanih stanica, prenose signala između moždanih stanica.
Although the following adverse drug reactions were not observed in the Prevenar 13 clinical studies in infants and children, the following are considered adverse drug reactions for Prevenar 13 as they were reported in the postmarketing experience.
Iako sljedeće nuspojave nisu bile zabilježene u kliničkim ispitivanjima Prevenara 13 u dojenčadi i djece, smatraju se nuspojavama Prevenara 13 jer su bile prijavljene nakon stavljanja tog cjepiva u promet.
Although the incidence of severe marrow suppression with clinical consequences is relatively low, patients have been treated with Pixuvri were closely monitored by frequent blood counts, particularly for neutropenia.
Iako je incidencija ozbiljne supresije koštane srži s kliničkim posljedicama relativno rijetka, bolesnici koji su liječeni Pixuvriom pažljivo su praćeni čestim provjerama krvne slike, naročito na pojavu znakova neutropenije.
Although the list of possible side effects can seem worrying, it’s possible that you may not have any of them.
Makar bi Vas popis mogućih nuspojava mogao zabrinuti, moguće je da ne dobijete niti jednu nuspojavu.
Although the main study was of short duration and the follow-up studies had shortcomings, the CHMP took the view that the effects shown after the initial 2 months of treatment are likely to be sustained for the full treatment duration.
Iako je glavno ispitivanje kratko trajalo, a kontrolna su ispitivanja imala nedostatke, CHMP je zauzeo stajalište da će se učinci dokazani nakon 2 mjeseca liječenja vjerojatno održati tijekom cijelog trajanja liječenja.
Although the main study was small and did not directly compare Strensiq with another treatment or with untreated patients, the CHMP considered that the improvement seen in the bones and the apparent growth was relevant.
Iako je glavno ispitivanje bilo malo i nije izravno usporedilo djelovanje lijeka Strensiq s nekom drugom terapijom ili s neliječenim bolesnicima, CHMP je zaključio da su uočeno poboljšanje u kostima i očit rast relevantni.
Although the molecular action of alitretinoin is thought to be mediated through interaction with the retinoid receptors, the exact mechanism of action of this medicinal product in the topical treatment of cutaneous lesions of AIDS-related KS is unknown.
Iako se smatra da je molekularno djelovanje alitretinoina posredovano interakcijom s retinoidnim receptorima, točan mehanizam djelovanja ovog lijeka u topikalnom liječenju kožnih lezija Kaposijevog sarkoma povezanog s AIDS-om to nije poznat.
Although the number of reported alopecia cases is rather low overall, it should be taken into account that there might be considerable underreporting for this non-serious adverse event.
Iako je broj prijavljenih slučajeva alopecije ukupno prilično nizak, potrebno je uzeti u obzir da je značajan broj ovih štetnih događaja koji nisu ozbiljne naravi možda ostao neprijavljen.
Although the occurrence of cardiac toxicity manifested by CHF appears to be lower than that would be expected with related medicinal products such as anthracyclines, monitoring of LVEF either by MUGA scans or ECHO is recommended to assess subclinical cardiotoxicity.
Iako se čini da je pojava kardijalne toksičnosti, koja se manifestira kroničnim zatajenjem srca, manja nego bi se to moglo očekivati sa srodnim lijekovima kao što su to antraciklini, preporučuje se praćenje LVEF pomoću MUGA-snimki ili UZV-a radi verifikacije subkliničkih znakova kardiotoksičnosti.
Although the outcome of some of the studies was partially compromised by the complex nature of PCV2 infections, the large number of pigs involved (from 63 farms) and the variety of experimental and clinical conditions did show a reduction in the overall death rates of piglets related to PCV2 infections of between 3.6% and 10%.
Iako je ishod pojedinih ispitivanja bio djelomično ugrožen kompleksnom prirodom infekcija PCV2, velikim brojem uključenih svinja (s 63 farme) i različitošću eksperimentalnih i kliničkih stanja dokazano je smanjivanje ukupne stope smrtnosti prasadi, koja je povezana s infekcijama PCV2, između 3,6% i 10%.
Although the population analysis showed no relationship between the serum liver enzymes concentrations and the plasma clearance of trabectedin, systemic exposure to trabectedin may be increased in patients with hepatic impairment; therefore close monitoring of toxicity is warranted.
Premda su analize unutar populacije pokazale da nema povezanosti između serumskih koncentracija jetrenih enzima i plazmatskog klirensa trabektedina, sistemska izloženost trabektedinu može se povećati kod bolesnika s oštećenjem jetre, te je stoga potrebno pomno praćenje toksičnosti.
Although the possible in vivo interaction of docetaxel with concomitantly administered medicinal products has not been investigated formally, in vitro interactions with tightly protein-bound drugs such as erythromycin, diphenhydramine, propranolol, propafenone, phenytoin, salicylate, sulfamethoxazole and sodium valproate did not affect protein binding of docetaxel.
Iako mogućnost interakcije docetaksela s istodobnom primjenom drugih lijekova in vivo nije formalno ispitana, in vitro interakcije s tvarima koje se čvrsto vezuju za proteine, poput eritromicina, difenhidramina, propranolola, propafenona, fenitoina, salicilata, sulfametoksazola i natrijevog valproata, nisu utjecale na vezanje docetaksela za proteine.
Although the potential for interactions with medicinal products seems low, for concomitant treatment with medicinal products with a narrow therapeutic window, the clinical effect and adverse events should be monitored, on initiation or dose- adjustment of either Velphoro or the concomitant medicinal product, or the physician should consider measuring blood levels.
Iako je potencijal za interakcije s drugim lijekovima nizak, pri istodobnom liječenju lijekovima s uskom terapijskom širinom, na početku liječenja ili kod prilagodbe doze lijeka Velphoro ili istodobno primijenjenog lijeka, potrebno je pratiti klinički učinak i nuspojave ili liječnik treba razmotriti mjerenje razina u krvi.
Although the precise mode of action is unclear, delamanid is known to block the production of methoxy-mycolic and keto-mycolic acids, two essential components of the cell walls of M. tuberculosis, which will cause the bacteria to die.
Iako je točan način djelovanja nejasan, poznato je da delamanid blokira stvaranje metoksi-mikoličnih i keto- mikoličnih kiselina, dviju esencijalnih komponenti stanične stjenke bakterije M. tuberculosis, što uzrokuje njezinu smrt.
Although the product may be safely administered to cats infected with adult heartworms, no therapeutic effect against adult Dirofilaria immitis has been established.
Iako se veterinarsko medicinski proizvod može sigurno primijeniti na mačkama, invadiranima odraslim dirofilarijama, ne postoje dokazi o ljekovitom učinku.
Although the relevance of this information for the target species (ornamental birds) is unknown, it is wise to avoid the use of such substances together with this product because an increase and/or a prolongation of their pharmacological effects, including side effects, may occur.
Iako značaj ove informacije za ciljne životinjske vrste nije poznat, preporuča se izbjegavanje istovremene primjene takvih tvari s ovim proizvodom zato što može nastupiti povećanje i/ili produljenje farmakološkog djelovanja, uključujući i nuspojave.
Although the relevance of this information for the target species is unknown, it would be prudent to avoid the concurrent use of such substances with this product because an increase and/or a prolongation of their pharmacological effects, including side effects, may occur.
Iako značaj ove informacije za ciljne životinjske vrste nije poznat, preporuča se izbjegavanje istovremene primjene takvih tvari s ovim proizvodom zato što može nastupiti povećanje i/ili produljenje farmakološkog djelovanja, uključujući i nuspojave.
Although the results of a single-dose interaction study with an oral contraceptive suggest the lack of a pharmacokinetic interaction, the results cannot exclude the possibility of changes in the pharmacokinetics that might affect the efficacy of the oral contraceptive during long-term treatment with Rapamune.
Iako rezultati ispitivanja interakcije jedne doze lijeka s oralnim kontraceptivom upućuju na to da nema farmakokinetičke interakcije, ti rezultati ne mogu isključiti mogućnost promjena u farmakokinetici koje bi mogle utjecati na djelotvornost oralnog kontraceptiva tijekom dugotrajnog liječenja Rapamuneom.
Although the results of pharmacokinetic analysis showed that there is considerable inter-subject variation, the mean exposure to imatinib did not increase in patients with varying degrees of liver dysfunction as compared to patients with normal liver function (see sections 4.2, 4.4 and 4.8).
Iako su rezultati farmakokinetičke analize pokazali da postoji značajna razlika između ispitanika, srednjavrijednost izloženosti imatinibu nije se povećala u bolesnika s različitim stupnjevima poremećaja funkcije jetre, u usporedbi s bolesnicima s normalnom funkcijom jetre (vidjeti dijelove 4.2, 4.4 i 4.8).
Although the studies showed a small higher risk of heart problems with Pradaxa than with warfarin, the benefits of Pradaxa were still considered to outweigh its risks.
Iako su ispitivanja pokazala nešto veći rizik od srčanih tegoba kod lijeka Pradaxa u usporedbi s varfarinom, smatra se da koristi od lijeka Pradaxa još uvijek nadmašuju s njim povezane rizike.
Although the studies showed that Imvanex is expected to protect against smallpox, it is not possible to determine from study results the exact level of protection or how long the protection would last.
Iako su ispitivanja pokazala da se očekuje da će Imvanex pružiti zaštitu od velikih boginja, iz rezultata ispitivanja nije moguće odrediti točnu razinu zaštite ili koliko će dugo ona trajati.
Although the underlying mechanism and safety relevance of this finding are not known, clinicians should use clinical judgment when assessing whether to prescribe ibrutinib to patients at risk from further shortening their QTc duration (e.g., Congenital Short QT Syndrome or patients with a family history of such a syndrome).
Iako osnovni mehanizam i značaj ovog nalaza za sigurnost primjene nisu poznati, liječnici moraju kliničkom procjenom donijeti odluku hoće li ibrutinib propisati bolesnicima koji imaju rizik za daljnje skraćenje QTc intervala (npr. sindrom kongenitalno skraćenog QT intervala ili bolesnici s takvim sindromom u obiteljskoj anamnezi).
Although the use of ellaOne does not contraindicate the continued use of regular hormonal contraception, ellaOne may reduce its contraceptive action (see section 4.5).
Iako pri uzimanju ellaOne nije kontraindicirana daljnja primjena redovne hormonske kontracepcije, ellaOne može smanjiti njezino kontracepcijsko djelovanje (vidjeti dio 4.5).
Although the veterinary medicinal product may be safely administered to cats infected with adult heartworms, no therapeutic effect against adult Dirofilaria immitis has been established.
Iako se veterinarsko medicinski proizvod može sigurno primijeniti na mačkama invadiranima odraslim dirofilarijama, ne postoje dokazi o ljekovitom učinku.
Although there are limited clinical data on the use of Emtricitabine/Tenofovir disoproxil Zentiva in pregnant women, it is not usually used unless absolutely necessary.
Postoje tek ograničeni klinički podaci o uporabi lijeka Emtricitabine/Tenofovir disoproxil Zentiva u trudnica, pa se lijek obično ne primjenjuje osim ako to nije apsolutno potrebno.
Although there are limited clinical data on the use of Truvada in pregnant women, it is not usually used unless absolutely necessary.
Iako postoje ograničeni klinički podaci o uporabi Truvade u trudnica, lijek se obično ne primjenjuje osim ako to nije apsolutno potrebno.
Although there are limited clinical data on the use of Viread in pregnant women, it is not usually used unless absolutely necessary.
Nema dovoljno kliničkih podataka o primjeni Vireada u trudnica, pa se on obično ne koristi osim ako to nije nužno potrebno.
Although there is a 49% decrease in Cmax of nateglinide in dialysis patients, the systemic availability and half-life in diabetic subjects with moderate to severe renal insufficiency (creatinine clearance 15–50 ml/min) was comparable between renal subjects requiring haemodialysis and healthy subjects.
Iako postoji smanjenje Cmax nateglinida od 49% u bolesnika koji idu na dijalizu, sistemska raspoloživost i poluvrijeme života u ispitanika sa šećernom bolešću s umjerenom do teškom bubrežnom insuficijencijom (klirens kreatinina 15-50 ml/min) bio je usporediv između ispitanika s oštećenjem bubrega koji su trebali hemodijalizu i zdravih ispitanika.
Although there is a potential for the development of progressive multifocal leukoencephalopathy (PML), no case of PML has been reported in the pivotal study.
Iako postoji mogućnost za razvoj progresivne multifokalne leukoencefalopatije (PML), u pivotalnom ispitivanju nije prijavljen ni jedan slučaj PML-a.
Although there is elimination of radioactivity in urine after administration of radiolabelled etanercept to patients and volunteers, increased etanercept concentrations were not observed in patients with acute renal failure.
Iako nakon primjene radioizotopom označenog etanercepta bolesnicima i dobrovljcima postoji eliminacija radioaktivnosti u mokraći, nisu bile opažene povećane koncentracije etanercepta u bolesnika s akutnim zatajenjem bubrega.
Although there is elimination of radioactivity in urine after administration of radiolabelled etanercept to patients and volunteers, increased etanercept concentrations were not observed in patients with acute renal failure.
Iako se nakon primjene radioizotopom označenog etanercepta bolesnicima i dobrovljcima postoji eliminacija radioaktivnosti u mokraći, nisu bile opažene povećane koncentracije etanercepta u bolesnika s akutnim zatajenjem bubrega.
Although there was no significant difference between the two groups in the percentages of subjects with antibody concentration  0.20 g/mL (ELISA), the percentages of subjects for serotypes 6B and 23F were lower than for the other vaccine serotypes (Table 7 and Table 8).
Iako nije bilo statistički značajne razlike između dviju skupina u postotku cijepljenih s koncentracijom protutijela  0,20 g/mL (ELISA), postotak ispitanika za serotipove 6B i 23F je bio niži nego za ostale serotipove sadržane u cjepivu (Tablica 7 i Tablica 8).
Although there were limitations in the studies, including lack of control group and low number of patients, the Agency’s Committee for Medicinal Products for Human Use (CHMP) decided that Darzalex’s benefits are greater than its risks and recommended that it be approved for use in the EU.
Bez obzira na ograničenja u ispitivanjima, među kojima su nedostatak kontrolne skupine i nizak broj bolesnika, Odbor za lijekove za humanu uporabu (CHMP) pri Agenciji odlučio je da koristi od lijeka Darzalex nadmašuju s njim povezane rizike te je preporučio njegovo odobrenje za korištenje u Europskoj uniji.
Although these biological side effects have not been reported in humans, the use of a low mechanical index and end- diastolic triggering is recommended.
Iako ovi biološki štetni učinci nisu zabilježeni kod ljudi, preporučena je uporaba niskog mehaničkog indeksa i ciljani prikaz na kraju dijastole.
Although these doses are not expected to exactly reproduce the pharmacokinetic profile of tenofovir in patients with normal renal function receiving tenofovir disoproxil (as fumarate) 245 mg film-coated tablets, they are considered to represent the best balance of benefit and risk for patients with renal impairment.
Iako se ne očekuje da će te doze točno reproducirati farmakokinetički profil tenofovira u pacijenata s normalnom funkcijom bubrega koji primaju tenofovirdizoproksil (u obliku tenofovirdizoproksilfumarata) 245 mg filmom obloženih tableta, one predstavljaju nabolju ravnotežu koristi i rizika za pacijente s oštećenjem bubrega.
Although these have not been seen in clinical trials involving UCD patients, high PAA levels should be suspected in patients with unexplained somnolence, confusion, nausea and lethargy who have normal or low ammonia.
Iako one nisu zabilježene u kliničkim ispitivanjima u bolesnika s poremećajima ciklusa ureje, kod bolesnika s neobjašnjenom somnolencijom, konfuzijom, mučninom i letargijom koji imaju normalnu ili sniženu razinu amonijaka treba posumnjati na visoke razine PAA.
Although these may appear normal (for example nappy rash), they might be rashes due to Viramune.
Iako se može činiti normalnim (npr. pelenski osip), takvi osipi mogu biti izazvani Viramuneom.
Although these side effects have so far not been seen with HyQvia, it is possible that someone using HyQvia may get them:
Iako te nuspojave nisu do sada opažene uz lijek HyQvia, postoji mogućnost da se pojave kod nekih osoba koje primjenjuju lijek HyQvia:
Although these studies are not conclusive, there is no evidence of interference of mifamurtide with the anti-tumour effects of chemotherapy and vice versa.
Iako ta ispitivanja nisu konačna, nema dokaza da mifamutid ometa antitumorsko djelovanje kemoterapije ili obrnuto.
Although this complication is very rare, you should be aware that if you develop it, you would need to have regular blood transfusions, possibly lifelong, to treat your anaemia and the Retacrit therapy would have to be discontinued.
Iako je ova komplikacija vrlo rijetka, trebate biti svjesni da ćete ukoliko je razvijete, radi liječenja anemije morati primati redovne transfuzije krvi, moguće tijekom cijelog života, a terapija Retacritom će se morati prekinuti.
Although Tivicay can normally be taken with or without food, patients whose virus is resistant to this class of medicines should take Tivicay with food as it helps the medicine to get absorbed.
Iako se Tivicay može normalno uzimati s ili bez hrane, bolesnici čiji je virus otporan na ovu klasu lijekova trebaju uzimati Tivicay s hranom, budući da hrana pomaže pri apsorpciji lijeka.
Although treatment will reduce the spread of infection, it will not be effective against the clinical signs of infection in already infected animals.
Iako će liječenje smanjiti širenje invazije, neće biti učinkovito protiv kliničkih simptoma invazije kod već invadiranih životinja.
Although treatment with edoxaban does not require routine monitoring, the effect on anticoagulation can be estimated by a calibrated quantitative anti-Factor Xa assay which may be useful in exceptional situations where knowledge of edoxaban exposure may help to inform clinical decisions, e.g. overdose and emergency surgery (see also section 4.4).
Iako liječenje edoksabanom ne zahtijeva rutinsko praćenje, učinak na antikoagulaciju može se procijeniti pomoću kalibriranog kvantitativnog anti-faktor Xa testa, koji može biti koristan u iznimnim situacijama kada poznavanje izloženosti edoksabanu može pomoći kao informacija kod donošenja kliničkih odluka, npr. kod predoziranja i hitnih kirurških zahvata (vidjeti također dio 4.4).
Although treatment with rivaroxaban does not require routine monitoring of exposure, rivaroxaban levels measured with a calibrated quantitative anti-factor Xa assay may be useful in exceptional situations where knowledge of rivaroxaban exposure may help to inform clinical decisions, e.g., overdose and emergency surgery (see sections 5.1 and 5.2).
Iako liječenje rivaroksabanom ne zahtijeva rutinsko praćenje izloženosti, mjerenje razine rivaroksabana kalibriranim kvantitativnim anti-faktor Xa testom može biti korisno u iznimnim situacijama gdje poznavanje izloženosti rivaroksabanu može pomoći kao informacija u kliničkim odlukama, npr. predoziranje i hitna operacija (vidjeti dijelove 5.1 i 5.2).