natgillin/translations-raw huggingface dataset:
In SPRING-2, dolutegravir was still non- inferior to raltegravir (viral suppression in 81% vs 76% of patients), and with a median change in CD4 count of 276 vs 264 cells/mm3, respectively.
U ispitivanju SPRING-2, dolutegravir je i dalje bio neinferioran u odnosu na raltegravir (virusna supresija postignuta je u 81% naspram 76% bolesnika), uz medijan promjene broja CD4 stanica od 276 stanica/mm3 (dolutegravir) naspram 264 stanica/mm3 (raltegravir).
In SPRING-2, four patients in the RAL-arm failed with major NRTI mutations and one with raltegravir resistance; in SINGLE, six patients in the EFV/TDF/FTC-arm failed with mutations associated with NNRTI resistance, and one developed a major NRTI mutation.
U ispitivanju SPRING-2, četiri ispitanika koja su primala RAL nisu odgovorila na liječenje te su imala značajne NRTI mutacije, a u jednog se ispitanika razvila rezistencija na raltegravir; u ispitivanju SINGLE, šest ispitanika koji su primali EFV/TDF/FTC nisu odgovorili na liječenje te su imali mutacije povezane s rezistencijom na NNRTI, dok se u jednog ispitanika razvila značajna NRTI mutacija.
In STEMI or UA/NSTEMI patients who are to undergo coronary artery bypass graft (CABG) surgery, fondaparinux where possible, should not be given during the 24 hours before surgery and may be restarted 48 hours post-operatively.
U bolesnika sa STEMI ili UA/NSTEMI koji se podvrgavaju operaciji ugradnje koronarne premosnice, fondaparinuks ne treba davati tijekom 24 sata prije operacije, ako je to moguće, a u terapiju se ponovo može uvesti 48 sati nakon zahvata.
In Still’s disease (AOSD or SJIA), you should not inject Ilaris earlier than 4 weeks after the last dose.
Kod Stillove bolesti (SBOD ili SJIA), ne smijete ubrizgati Ilaris prije nego što prođe 4 tjedna od posljednje doze.
In Still’s disease, patients with a body weight of 7.5 kg or above are given 4 mg per kilogram body weight (up to a maximum dose of 300 mg) as an injection under the skin every four weeks.
U slučaju Stillove bolesti, bolesnici s tjelesnom težinom od 7,5 kg ili više primaju dozu od 4 mg po kilogramu tjelesne težine (do maksimalne doze od 300 mg) kao injekciju pod kožu svaka četiri tjedna.
In studies 1 and 2 in patients with the G551D mutation in one allele of the CFTR gene, ivacaftor led to rapid (15 days), substantial (the mean change in sweat chloride from baseline through week 24 was -48 mmol/L [95% CI -51, -45] and -54 mmol/L [95% CI -62, -47], respectively) and sustained (through 48 weeks) reductions in sweat chloride concentration.
U ispitivanjima 1 i 2 u bolesnika s G551D mutacijom jednog alela gena CFTR, ivakaftor je doveo do brzog (15 dana), znatnog (prosječna promjena koncentracije klorida u znoju od početka do 24. tjedna iznosila je -48 mmol/l 95% [CI -51; -45] odnosno -54 mmol/l [95% CI -62; -47]) i održanog (do 48 tjedana) smanjenja koncentracije klorida u znoju.
In studies 312-0116/0117 and 312-0119, rash (reported as dermatitis exfoliative, rash, rash erythematous, rash generalised, rash macular, rash maculo-papular, rash papular, rash pruritic, and skin disorder) occurred in 28.3% of subjects who received idelalisib + an anti-CD20 monoclonal antibody (rituximab or ofatumumab) and 7.7% who received an anti-CD20 monoclonal antibody only (rituximab or ofatumumab).
U ispitivanjima 312-0116/0117 i 312-0119, osip (zabilježen kao eksfolijativni dermatitis, osip, eritematozni osip, generalizirani osip, makularni osip, makulopapularni osip, papularni osip, pruritični osip i poremećaj kože) se pojavio u 28,3% ispitanika koji su primali idelalisib + anti-CD20 monoklonsko protutijelo (rituksimab ili ofatumumab) i 7,7% onih koji su primali samo anti-CD20 monoklonsko protutijelo (rituksimab ili ofatumumab).
In Studies A and B, brain metastases were seen in 60.1% and 71.4% of patients, respectively.
U Ispitivanjima A i B, metastaze na mozgu bile su uočene u 60,1% odnosno 71,4% bolesnika.
In studies C208 (QUEST-1) and C216 (QUEST-2), treatment-naïve patients received simeprevir (150 mg once daily) + peginterferon alfa + ribavirin for 12 weeks, followed by 12 or 36 additional weeks of peginterferon alfa + ribavirin (see tables 17 and 18).
U ispitivanjima C208 (QUEST-1) i C216 (QUEST-2), bolesnici koji prethodno nisu bili liječeni primali su simeprevir (150 mg jedanput dnevno) + peginterferon alfa + ribavirin tijekom 12 tjedana, nako čega je slijedilo dodatnih 12 ili 36 tjedana peginterferona alfa + ribavirina (vidjeti tablice 17 i 18).
In studies conducted in healthy subjects, neither the pharmacokinetics of saxagliptin and its major metabolite, were meaningfully altered by metformin, glibenclamide, pioglitazone, digoxin, simvastatin, omeprazole, antacids or famotidine.
U ispitivanjima na zdravim ispitanicima primjena metformina, glibenklamida, pioglitazona, digoksina, simvastatina, omeprazola, antacida ili famotidina nije značajno promijenila farmakokinetiku saksagliptina ni njegova glavnog metabolita.
In studies conducted in healthy subjects, neither the pharmacokinetics of saxagliptin and its major metabolite, were meaningfully altered by metformin, glibenclamide, pioglitazone, digoxin, simvastatin, omeprazole, antacids or famotidine.
U ispitivanjima provedenim u zdravih ispitanika primjena metformina, glibenklamida, pioglitazona, digoksina, simvastatina, omeprazola, antacida ili famotidina nije značajno promijenila farmakokinetiku saksagliptina ni njegova glavnog metabolita.
In studies conducted in rabbits, bazedoxifene alone has shown reproductive toxicity (see section 5.3).
U ispitivanjima provedenim na kunićima, bazedoksifen sam pokazao je reproduktivnu toksičnost (vidjeti dio 5.3).
In studies demonstrating superiority of XGEVA to zoledronic acid, patients were offered open label XGEVA in a pre-specified 2-year extension treatment phase.
U kliničkim ispitivanjima koja su pokazala superiornost lijeka XGEVA u usporedbi sa zoledronatnom kiselinom, bolesnicima je otvoreno ponuđena XGEVA u unaprijed specificiranom dvogodišnjem nastavku faze liječenja.
In studies DPM-CF-301 and 302 relative % predicted FEV1 compared to control in children (6-11 years) was improved by 0.44% (95% CI -5.90, 6.77, N=43) and 6.1% (95% CI -1.28, 13.54, N=59) over 26 weeks (p=0.892 and 0.104) respectively.
U ispitivanjima DPM-CF-301 i 302, procijenjeni relativni % FEV1 u odnosu na kontrolnu skupinu u djece (u dobi od 6 do 11 godina) poboljšan je za 0,44% (95% CI -5,90, 6,77, N = 43) te 6,1% (95% CI
In Studies ESTEEM 1 and ESTEEM 2, significant improvements in scalp psoriasis of at least moderate severity (≥3), measured by the proportion of patients achieving Scalp Psoriasis Physician’s Global Assessment (ScPGA) of clear (0) or minimal (1) at Week 16, were observed in patients receiving apremilast compared to placebo-treated patients (p< 0.0001 for both studies).
U ispitivanjima ESTEEM 1 i ESTEEM 2, značajna poboljšanja u psorijazi vlasišta koja je bila najmanje umjerene težine (≥ 3), mjereno kao udio bolesnika s psorijazom vlasišta koji su prema Općoj procjeni liječnika (ScPGA) u 16. tjednu postigli rezultat 'bez znakova' (0) ili 'gotovo bez znakova' (1), opažena su u bolesnika koji su primali apremilast u usporedbi s onima koji su primali placebo (p < 0,0001 u oba ispitivanja).
In studies GS-US-174-0102 and GS-US-174-0103, 77% and 61% of patients continued in the study through to 384 weeks, respectively.
U ispitivanju GS-US-174-0102, 77% pacijenata nastavilo je liječenje tijekom 384 tjedna, dok je u ispitivanju GS-US-174-0103 to učinilo 61% pacijenata.
In studies GS-US-292-0104 and GS-US-292-0111, E/C/F/TAF met the non-inferiority criteria in achieving HIV-1 RNA < 50 copies/mL when compared to E/C/F/TDF.
U ispitivanjima GS-US-292-0104 i GS-US-292-0111, E/C/F/TAF je ispunio kriterije neinferiornosti u postizanju vrijednosti HIV-1 RNK < 50 kopija/ml u usporedbi s E/C/F/TDF.
In studies GS-US-292-0104 and GS-US-292-0111, patients were randomised in a 1:1 ratio to receive either emtricitabine 200 mg and tenofovir alafenamide 10 mg (n = 866) once daily or emtricitabine 200 mg + tenofovir disoproxil (as fumarate) 245 mg (n = 867) once daily, both given with elvitegravir 150 mg + cobicistat 150 mg as a fixed-dose combination tablet.
U ispitivanjima GS-US-292-0104 i GS-US-292-0111 bolesnici su bili randomizirani u omjeru 1:1 kako bi primali emtricitabin 200 mg i tenofoviralafenamid 10 mg (n = 866) jednom dnevno ili emtricitabin 200 mg i tenofovirdizoproksil (u obliku fumarata) 245 mg (n = 867) jednom dnevno, s time da su obje terapije davane u fiksnoj kombinaciji s elvitegravirom 150 mg i kobicistatom 150 mg u jednoj tableti.
In studies GS-US-292-0104 and GS-US-292-0111, patients were randomised in a 1:1 ratio to receive either Genvoya (n = 866) once daily or elvitegravir 150 mg/cobicistat 150 mg/emtricitabine
U ispitivanjima GS-US-292-0104 i GS-US-292-0111 bolesnici su bili randomizirani u omjeru 1:1 kako bi primali lijek Genvoya (n = 866) jednom dnevno ili elvitegravir 150 mg/kobicistat
In studies GS-US-292-0104 and GS-US-292-0111, the rate of virologic success was similar across patient subgroups (age, gender, race, baseline HIV-1 RNA, or baseline CD4+ cell count).
U ispitivanjima GS-US-292-0104 i GS-US-292-0111, razina virološkog uspjeha bila je slična kod svih podskupina bolesnika (dob, spol, rasa, početna HIV-1 RNK, ili početni broj CD4+ stanica).
In Studies I and II only, patients were required to have at least one asthma exacerbation requiring systemic corticosteroid use in the year prior to study entry.
Bolesnici su morali imati najmanje jednu egzacerbaciju astme koja je zahtijevala primjenu sistemskih kortikosteroida u godinu dana prije ulaska u ispitivanje samo u Ispitivanjima I i II.
In Studies I and II, patients receiving reslizumab 3 mg/kg had significant reductions in asthma exacerbations (50% and 59%, respectively) compared to placebo (see Table 3).
U Ispitivanjima I i II, bolesnici koji su primali reslizumab u dozi od 3 mg/kg imali su značajno smanjenje egzacerbacija astme (50 % odnosno 59 %) u usporedbi s placebom (vidjeti tablicu 3).
In Studies I, II, and V the efficacy and safety of abatacept compared to placebo were assessed in patients with an inadequate response to methotrexate and who continued on their stable dose of methotrexate.
U Ispitivanjima I, II i V ispitivala se djelotvornost i sigurnost abatacepta u usporedbi s placebom u bolesnika koji nisu dovoljno dobro odgovorili na metotreksat i koji su nastavili uzimati metotreksat u svojim stabilnim dozama.
In studies in adults and children with plaque psoriasis, a higher proportion of patients receiving Humira had improvements in symptoms compared with patients receiving methotrexate.
U ispitivanju provedenom među djecom s plak psorijazom, veći postotak bolesnika koji su primali lijek Humira imao je poboljšanje simptoma u usporedbi s bolesnicima koji su primali metotreksat.
In studies in healthy subjects, no evidence of any interaction has been indicated between granisetron and benzodiazepines (lorazepam), neuroleptics (haloperidol) or anti-ulcer medicinal products (cimetidine).
U ispitivanjima na zdravim osobama nisu utvrđene interakcije između granisetrona i benzodiazepina (lorazepam), neuroleptika (haloperidol) ili antiulkusnih lijekova (cimetidin).
In studies in lamivudine-refractory patients, with only limited numbers of patients being followed up, 11% of entecavir-treated patients and no lamivudine-treated patients developed ALT elevations during post- treatment follow-up.
U ispitivanjima u bolesnika s hepatitisom refrakternim na lamivudin, kad se pratio samo ograničen broj bolesnika, povišenja ALT-a tijekom praćenja nakon liječenja nastupila su u 11% bolesnika liječenih entekavirom i niti u jednog bolesnika liječenog lamivudinom.
In studies in patients with compensated liver disease, histological improvement was defined as a ≥ 2- point decrease in Knodell necro-inflammatory score from baseline with no worsening of the Knodell fibrosis score.
U ispitivanjima u bolesnika s kompenziranom bolešću jetre, histološko poboljšanje definiralo se kao smanjenje za ≥ 2 boda na Knodellovom indeksu nekroze i upale u odnosu na početnu vrijednost, bez pogoršanja Knodellovog indeksa fibroze.
In studies in patients with relapsed multiple myeloma treated with bortezomib and in patients with previously untreated MCL treated with bortezomib in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (BR-CAP), one of the most common haematologic toxicity was transient thrombocytopenia.
U ispitivanjima s bolesnicima s relapsom multiplog mijeloma liječenih s bortezomibom i s bolesnicima s prethodno neliječnim limfomom plaštenih stanica liječenih s bortezomibom u kombinaciji s rituksimabom, ciklofosfamidom, doksorubicinom i prednizonom (BR-CAP), jedna od najčešćih hematoloških toksičnosti bila je prolazna trombocitopenija.
In studies in patients with relapsed multiple myeloma treated with bortezomib and in patients with previously untreated MCL treated with bortezomib in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (BzmbR-CAP), one of the most common haematologic toxicity was transient thrombocytopenia.
U ispitivanjima s bolesnicima s relapsom multiplog mijeloma liječenih bortezomibom i s bolesnicima s prethodno neliječnim limfomom plaštenih stanica liječenih bortezomibom u kombinaciji s rituksimabom, ciklofosfamidom, doksorubicinom i prednizonom (BzmbR-CAP), jedna od najčešćih hematoloških toksičnosti bila je prolazna trombocitopenija.
In studies in patients with relapsed multiple myeloma treated with bortezomib and in patients with previously untreated MCL treated with bortezomib in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (BzR-CAP), one of the most common haematologic toxicity was transient thrombocytopenia.
U ispitivanjima s bolesnicima s relapsom multiplog mijeloma liječenih s bortezomibom i s bolesnicima s prethodno neliječnim limfomom plaštenih stanica liječenih s bortezomibom u kombinaciji s rituksimabom, ciklofosfamidom, doksorubicinom i prednizonom (BzR-CAP), jedna od najčešćih hematoloških toksičnosti bila je prolazna trombocitopenija.
In studies in patients with relapsed multiple myeloma treated with VELCADE and in patients with previously untreated MCL treated with VELCADE in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (VcR-CAP), one of the most common haematologic toxicity was transient thrombocytopenia.
U ispitivanjima s bolesnicima s relapsom multiplog mijeloma liječenih s VELCADEom i s bolesnicima s prethodno neliječnim limfomom plaštenih stanica liječenih s VELCADEom u kombinaciji s rituksimabom, ciklofosfamidom, doksorubicinom i prednizonom (VcR-CAP), jedna od najčešćih hematoloških toksičnosti bila je prolazna trombocitopenija.
In studies in treatment- naïve patients, increases from baseline were observed in both the tenofovir alafenamide fumarate and tenofovir disoproxil fumarate containing treatment groups for the fasting lipid parameters total cholesterol, direct low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, and triglycerides at Week 96.
U ispitivanjima bolesnika koji prethodno nisu bili liječeni, i u skupini liječenoj tenofoviralafenamidfumaratom i u skupini liječenoj tenofovirdizoproksilfumaratom uočen je porast u odnosu na početne vrijednosti lipida natašte, i to za ukupni kolesterol, lipoproteine niske gustoće (LDL) i lipoproteine visoke gustoće (HDL) te trigliceride, u 96. tjednu.
In studies in treatment-naïve adult patients, E/C/F/TAF was associated with lower impact on renal safety parameters (as measured by eGFRCG, urine protein to creatinine ratio and urine albumin to creatinine ratio) compared to E/C/F/TDF after 96 weeks of treatment (see also section 4.4).
U ispitivanjima u odraslih bolesnika koji prethodno nisu bili liječeni, E/C/F/TAF bio je povezan s manjim utjecajem na parametre sigurnosti primjene za bubrege (mjereno prema eGFRCG, omjeru proteina i kreatinina u mokraći i omjeru albumina i kreatinina u mokraći) u usporedbi s E/C/F/TDF nakon 96 tjedana liječenja (vidjeti također dio 4.4).
In studies in treatment-naïve adult patients, E/C/F/TAF was associated with smaller reductions in bone mineral density (BMD; as measured by hip and lumbar spine DXA analysis) compared to E/C/F/TDF after 96 weeks of treatment.
U ispitivanjima u odraslih bolesnika koji prethodno nisu bili liječeni, E/C/F/TAF bio je povezan s manjim smanjenjima mineralne gustoće kosti (BMD; izmjereno DXA denzitometrijom kuka i lumbalne kralježnice) u usporedbi s E/C/F/TDF nakon 96 tjedana liječenja.
In studies in treatment-naïve patients, emtricitabine and tenofovir alafenamide given with elvitegravir and cobicistat (through 96 weeks) or darunavir and cobicistat (through 48 weeks) as a fixed-dose combination tablet was associated with a lower impact on renal safety parameters (as measured by eGFRCG, urine protein to creatinine ratio, and urine albumin to creatinine ratio) compared to E/C/F/TDF or darunavir and cobicistat and emtricitabine/tenofovir disoproxil fumarate (see also section 4.4).
U ispitivanjima u bolesnika koji prethodno nisu bili liječeni, fiksna kombinacija emtricitabina i tenofoviralafenamida s elvitegravirom i kobicistatom (tijekom 96 tjedana) ili darunavirom i kobicistatom (tijekom 48 tjedana) u jednoj tableti bila je povezana s manjim utjecajem na parametre sigurnosti primjene za bubrege (mjereno prema eGFRCG, omjeru proteina i kreatinina u mokraći i omjeru albumina i kreatinina u mokraći) u usporedbi s E/C/F/TDF ili darunavirom i kobicistatom i emtricitabinom/tenofovirdizoproksilfumaratom (vidjeti takoĎer dio 4.4).
In studies in treatment-naïve patients, emtricitabine and tenofovir alafenamide given with elvitegravir and cobicistat (through 96 weeks) or darunavir and cobicistat (through 48 weeks) as a fixed-dose combination tablet was associated with a lower impact onrenal safety parameters (as measured by eGFRCG, urine protein to creatinine ratio, and urine albumin to creatinine ratio) compared to E/C/F/TDF or darunavir and cobicistat and emtricitabine/tenofovir disoproxil fumarate (see also section 4.4).
U ispitivanjima u bolesnika koji prethodno nisu bili liječeni, fiksna kombinacija emtricitabina i tenofoviralafenamida s elvitegravirom i kobicistatom (tijekom 96 tjedana) ili darunavirom i kobicistatom (tijekom 48 tjedana) u jednoj tableti bila je povezana s manjim utjecajem na parametre sigurnosti primjene za bubrege (mjereno prema eGFRCG, omjeru proteina i kreatinina u mokraći i omjeru albumina i kreatinina u mokraći) u usporedbi s E/C/F/TDF ili darunavirom i kobicistatom i emtricitabinom/tenofovirdizoproksilfumaratom (vidjeti takoĎer dio 4.4).
In studies in treatment-naïve patients, emtricitabine and tenofovir alafenamide given with elvitegravir and cobicistat (through 96 weeks) or darunavir and cobicistat (through 48 weeks) as a fixed-dose combination tablet was associated with smaller reductions in bone mineral density (BMD; as measured by hip and lumbar spine dual energy X ray absorptiometry [DXA] analysis) compared to E/C/F/TDF or darunavir, cobicistat, emtricitabine and tenofovir disoproxil fumarate.
U ispitivanjima u bolesnika koji prethodno nisu bili liječeni, fiksna kombinacija emtricitabina i tenofoviralafenamida s elvitegravirom i kobicistatom (tijekom 96 tjedana) ili darunavirom i kobicistatom (tijekom 48 tjedana) u jednoj tableti bila je povezana s manjim smanjenjima mineralne gustoće kosti (BMD; izmjereno analizom kuka i lumbalne kraljeţnice dvoenergetskom apsorpciometrijom x zraka [DXA]) u usporedbi s E/C/F/TDF ili darunavirom, kobicistatom, emtricitabinom i tenofovirdizoproksilfumaratom nakon.
In studies in treatment-naïve patients, emtricitabine and tenofovir alafenamide given with elvitegravir and cobicistat (through 96 weeks) or darunavir and cobicistat (through 48 weeks) as a fixed-dose combination tablet was associated with smaller reductions in bone mineral density (BMD; as measured by hip and lumbar spine dual energy X ray absorptiometry [DXA] analysis) compared to E/C/F/TDF or darunavir, cobicistat, emtricitabine and tenofovir disoproxil fumarate.
U ispitivanjima u bolesnika koji prethodno nisu bili liječeni, fiksna kombinacija emtricitabina i tenofoviralafenamida s elvitegravirom i kobicistatom (tijekom 96 tjedana) ili darunavirom i kobicistatom (tijekom 48 tjedana) u jednoj tableti bila je povezana s manjim smanjenjima mineralne gustoće kosti (BMD; izmjereno analizom kuka i lumbalne kraljeţnice dvoenergetskom apsorpciometrijom x zraka [DXA]) u usporedbi s E/C/F/TDF ili darunavirom, kobicistatom, emtricitabinom i tenofovirdizoproksilfumaratom.
In studies in treatment-naïve patients, increases from baseline were observed in both the tenofovir alafenamide fumarate and tenofovir disoproxil fumarate containing treatment groups for the fasting lipid parameters total cholesterol, direct low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, and triglycerides at Week 96.
U ispitivanjima bolesnika koji prethodno nisu bili liječeni, i u skupini liječenoj tenofoviralafenamidfumaratom i u skupini liječenoj tenofovirdizoproksilfumaratom uočen je porast u odnosu na početne vrijednosti lipida natašte, i to za ukupni kolesterol, lipoproteine niske gustoće (LDL) i lipoproteine visoke gustoće (HDL) te trigliceride, u 96. tjednu.
In studies in treatment-naïve patients, increases from baseline were observed in both treatment groups for the fasting lipid parameters total cholesterol, direct low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, and triglycerides at Week 96.
U ispitivanjima u bolesnika koji prethodno nisu bili liječeni, u obje liječene skupine uočen je porast u odnosu na početne vrijednosti lipida natašte, i to za ukupni kolesterol, lipoproteine niske gustoće (LDL) i lipoproteine visoke gustoće (HDL) te trigliceride, u 96. tjednu.
In studies in vitro, alogliptin was found to be neither a substrate nor an inhibitor of key transporters associated with drug disposition in the kidney: organic anion transporter-1, organic anion transporter-3 or organic cationic transporter-2 (OCT2).
U in vitro ispitivanjima nađeno je da alogliptin nije supstrat ni inhibitor ključnih transportera povezanih s dispozicijom lijeka u bubrezima: transportera organskih aniona-1 (OAT-1), transportera organskih aniona-3 (OAT-3) ili transportera organskih kationa-2 (OCT2).
In studies in vitro, alogliptin was found to be neither a substrate nor an inhibitor of key transporters associated with drug disposition in the kidney: organic anion transporter-1, organic anion transporter-3 or organic cationic transporter-2 (OCT2).
U in vitro ispitivanjima nađeno je da alogliptin nije supstrat niti inhibitor ključnih transportera povezanih s dispozicijom lijeka u bubrezima: transportera organskih aniona-1 (engl. organic anion transporter-1, OAT-1), prijenosnika organskih aniona-3 (engl. organic anion transporter-3, OAT-3) ili prijenosnika organskih kationa-2 (engl. organic cation transporter-2, OCT2).
In studies in vitro, alogliptin was found to be neither a substrate nor an inhibitor of key transporters associated with drug disposition in the kidney: organic anion transporter-1, organic anion transporter-3 or organic cationic transporter-2 (OCT2).
U in vitro ispitivanjima nađeno je da alogliptin nije supstrat niti inhibitor ključnih transportera povezanih s dispozicijom lijeka u bubrezima: transportera organskih aniona-1 (OAT-1), transportera organskih aniona-3 (OAT-3) ili transportera organskih kationa-2 (OCT2).
In studies of 26 weeks duration, the incidence of discontinuation due to adverse events was 2.6% (0.75 mg) and 6.1% (1.5 mg) for dulaglutide versus 3.7 % for placebo.
U 26-tjednim ispitivanjima, incidencija prekida liječenja zbog štetnih događaja iznosila je 2,6% (0,75 mg) i 6,1% (1,5 mg) za dulaglutid naspram 3,7% za placebo.
In studies of bimatoprost 0.3 mg/ml in patients with glaucoma or ocular hypertension, it has been shown that more frequent exposure of the eye to more than 1 dose of bimatoprost daily may decrease the IOP-lowering effect.
U ispitivanjima primjene bimatoprosta 0,3 mg/ml u bolesnika s glaukomom ili povišenim očnim tlakom utvrđeno je da izlaganje oka više od jednoj dozi bimatoprosta dnevno može smanjiti njegovu učinkovitost u snižavanju intraokularnog tlaka.