natgillin/translations-raw huggingface dataset:
As serious and life threatening hepatotoxicity has been observed in controlled and uncontrolled studies predominantly in patients with a plasma HIV-1 viral load of 50 copies/ml or higher, nevirapine should not be initiated in adult females with CD4 cell counts greater than 250 cells/mm3 or in adult males with CD4 cell counts greater than 400 cells/mm3, who have a detectable plasma HIV-1 RNA unless the benefit outweighs the risk.
HIV-1 virusnim opterećenjem u plazmi od 50 kopija/ml ili više, primjena nevirapina ne smije se početi u odraslih žena s brojem CD4 većim od 250 stanica/mm3 ili u odraslih muškaraca s brojem CD4 stanica većim od 400 stanica/mm3 koji imaju detektibilan HIV 1RNK u plazmi, osim ako mogući pozitivni učinci ne nadilaze rizike.
As serious and life threatening hepatotoxicity has been observed in controlled and uncontrolled studies predominantly in patients with a plasma HIV-1 viral load of 50 copies/ml or higher, nevirapine should not be initiated in adult females with CD4 cell counts greater than 250 cells/mm3 or in adult males with CD4 cell counts greater than 400 cells/mm3, who have a detectable plasma HIV-1 RNA unless the benefit outweighs the risk.
S obzirom na slučajeve teške i po život opasne hepatotoksičnosti opažene u kontroliranim i nekontroliranim studijama, uglavnom u bolesnika s HIV-1 virusnim opterećenjem u plazmi od 50 kopija/ml ili više, primjena nevirapina ne smije se početi u odraslih žena s brojem CD4 većim od 250 stanica/mm3 ili u odraslih muškaraca s brojem CD4 stanica većim od 400 stanica/mm3 koji imaju detektibilan HIV 1-RNK u plazmi, osim ako moguće koristi ne nadilaze rizike.
As shown in table 4 below, the absolute bioavailability of isavuconazole following oral administration of a single dose of CRESEMBA is 98%.
Kao što je prikazano u Tablici 4 u nastavku, apsolutna bioraspoloţivost izavukonazola nakon peroralne primjene jedne doze lijeka CRESEMBA je 98%.
As solvent Sterilised Water for Injections is used.
Kao otapalo koristi se sterilizirana voda za injekcije.
As some other tyrosine kinase inhibitors are known to exert an effect on QT, caution should be exercised when administered nintedanib in patients who may develop QTc prolongation.
Budući da je poznato da neki drugi inhibitori tirozin kinaze utječu na QT-interval, nužan je oprez pri primjeni nintedaniba u bolesnika koji mogu razviti produljenje QTc-intervala.
As soon as data becomes available
Čim podaci postanu dostupni
As soon as possible in the event of an illness or a condition leading to immobilization, the treatment should be discontinued.
U slučaju bolesti ili stanja koja dovodi do imobilizacije, liječenje treba što je moguće prije prekinuti.
As soon as skin and/or mucosal reactions are observed which raise the suspicion of such severe reactions, Leflunomide Winthrop and any other possibly associated treatment must be discontinued, and a leflunomide washout procedure initiated immediately.
Čim se pojave reakcije na koži i/ili sluznici koje izazivaju sumnju na teške nuspojave, uzimanje lijeka Leflunomide Winthrop ili bilo kojeg dodatnog lijeka treba prekinuti i odmah započeti postupak ispiranja leflunomida.
As soon as the first liquid stool occurs, start drinking large volumes ofrehydration fluids (е.g. water, soda water, fizzy drinks, soup) to avoid losing too much liquid and salts from your body.
Što prije nakon što dobijete prvu tekuću stolicu, počnite piti velike količine rehidracijske tekućine (npr. voda, gazirana voda, gazirana pića, juha) kako biste izbjegli gubljenje previše tekućine i soli iz tijela.
As soon as the tablet is disintegrated, swallow the content of the teaspoon.
Čim se tableta rastopi, progutajte sadržaj čajne žličice.
As soon as they are thawed, open ampoules holding them at arm’s length in order to prevent any risk of injury should an ampoule break.
Čim su otopljene, otvarajte ampule tako da ih držite na udaljenosti dužine ruke kako bi se spriječila opasnost od povrede ako se ampula slomi.
As soon as you have done the injection, take the needle off the pen using the outer needle cap.
Odmah nakon injekcije skinite iglu s brizgalice pomoću vanjskog zatvarača igle.
As soon as you have done the injection, unscrew the needle from the KwikPen using the outer needle cap.
Odmah nakon injekcije odvijte iglu s KwikPen brizgalice pomoću vanjskog zatvarača igle.
As soon as you remember, remove the old patch and apply a new one to a new spot on your abdomen, hips or buttocks.
Čim se sjetite, uklonite stari flaster i primijenite novi na novo mjesto na abdomenu, kukovima ili stražnjici.
As spironolactone has an antiandrogenic effect (acts against male hormones), it is not recommended to administer the veterinary medicinal product to growing dogs.
Spironolakton ima antiandrogeni učinak, pa se ne preporuča njegovo davanje psima u rastu.
As spironolactone undergoes extensive hepatic biotransformation, care should be taken when using the veterinary medicinal product to treat dogs with hepatic dysfunction.
Kako spironolakton prolazi opsežnu biotransformacija u jetri potrebno ga je oprezno koristiti u liječenju pasa s jetrenom disfunkcijom.
As spironolactone undergoes extensive hepatic biotransformation, care should be taken when using the veterinary medicinal product to treat dogs with hepatic dysfunction.
Kako spironolakton prolazi opsežnu biotransformaciju u jetri potrebno ga je oprezno koristiti u liječenju pasa s jetrenom disfunkcijom.
As splenic enlargement is a common finding in patients with HIV infection and is present to varying degrees in most patients with AIDS, the relationship to filgrastim treatment is unclear (see section 4.4)..
Povećanje slezene česti je nalaz kod bolesnika s HIV-infekcijom i prisutan u različitim stupnjevima u većine bolesnika s AIDS-om, no odnos s liječenjem filgrastimom nije jasan (vidjeti dio 4.4).
As splenic enlargement is a common finding in patients with HIV infection and is present to varying degrees in most patients with AIDS, the relationship to filgrastim treatment is unclear(see section 4.4).
Povećanje slezene česti je nalaz kod bolesnika s HIV-infekcijom i prisutan u različitim stupnjevima u većine bolesnika s AIDS-om, no odnos s liječenjem filgrastimom nije jasan (vidjeti dio 4.4).
As splenomegaly is a common finding in patients with HIV infection and is present to varying degrees in most patients with AIDS, the relationship to filgrastim treatment is unclear (see section 4.4).
Budući da je splenomegalija čest nalaz u bolesnika s HIV-infekcijom i prisutna je u različitim stupnjevima u većini bolesnika s AIDS-om, povezanost s liječenjem filgrastimom nije jasna (vidjeti dio 4.4).
As splenomegaly is a common finding in patients with HIV infection and is present to varying degrees in most patients with AIDS, the relationship to filgrastim treatment is unclear (see section 4.4).
Kako je splenomegalija čest nalaz u bolesnika s HIV infekcijom i u različitim je stupnjevima prisutno u većine bolesnika s AIDS-om, povezanost s filgrastimom nije jasna (vidjeti dio 4.4).
As splenomegaly is a common finding in patients with HIV infection and is present to varying degrees in most patients with AIDS, the relationship to filgrastim treatment is unclear (see section 4.4).
Splenomegalija je česti nalaz kod bolesnika s HIV-infekcijom i prisutan u različitim stupnjevima u većine bolesnika s AIDS- om, no odnos s liječenjem filgrastimom nije jasan (vidjeti dio 4.4).
As splenomegaly is a common finding in patients with HIV infection and is present to varying degrees in most patients with AIDS, the relationship to filgrastim treatment is unclear (see section 4.4).
Splenomegalija je česti nalaz kod bolesnika s HIV-infekcijom i prisutan u različitim stupnjevima u većine bolesnika s AIDS-om, no odnos s liječenjem filgrastimom nije jasan (vidjeti dio 4.4).
As stated in section 4.2, the safety and efficacy of Bronchitol in children and adolescents aged less than 18 years has not been established.
Kao što je naznačeno u dijelu 4.2, sigurnost i djelotvornost lijeka Bronchitol u djece i adolescenata mlađih od 18 godina nisu ustanovljene.
As stiripentol inhibited CYP2D6 in vitro at concentrations that are achieved clinically in plasma, substances that are metabolized by this isoenzyme like: beta-blockers (propranolol, carvedilol, timolol), antidepressants (fluoxetine, paroxetine, sertraline, imipramine, clomipramine), antipsychotics (haloperidol), analgesics (codeine, dextromethorphan, tramadol) may be subject to metabolic interactions with stiripentol.
S obzirom da stiripentol inhibira CYP2D6 in vitro u koncentacijama koje se klinički dostižu u plazmi, tvari koje se metaboliziraju ovim izoenzimima kao što su: : beta blokatori (propranolol, karvedilol, timolol), antidepresivi (fluoksetin, paroksetin, sertralin, imipramin, klomipramin), antipsihotici (haloperidol), analgetici (kodein, dekstrometorfan, tramadol) mogu imati metaboličke interakcije sa stiripentolom.
As stiripentol inhibited CYP2D6 in vitro at concentrations that are achieved clinically in plasma, substances that are metabolized by this isoenzyme like: beta-blockers (propranolol, carvedilol, timolol), antidepressants (fluoxetine, paroxetine, sertraline, imipramine, clomipramine), antipsychotics (haloperidol), analgesics (codeine, dextromethorphan, tramadol) may be subject to metabolic interactions with stiripentol.
S obzirom da stiripentol inhibira CYP2D6 in vitro u koncentacijama koje se klinički dostižu u plazmi, tvari koje se metaboliziraju ovim izoenzimima kao što su: beta blokatori (propranolol, karvedilol, timolol), antidepresivi (fluoksetin, paroksetin, sertralin, imipramin, klomipramin), antipsihotici (haloperidol), analgetici (kodein, dekstrometorfan, tramadol) mogu imati metaboličke interakcije sa stiripentolom.
As Stribild contains elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate, any interactions that have been identified with these active substances individually may occur with Stribild.
Stribild sadrži elvitegravir, kobicistat, emtricitabin i tenofovirdizoproksilfumarat, pa sve interakcije koje su utvrđene u zasebnoj primjeni s tim djelatnim tvarima mogu nastupiti i s Stribildom.
AS Study 1 (MEASURE 1) evaluated 371 patients, of whom 14.8% and 33.4% used concomitant MTX or sulfasalazine, respectively.
Prvo ispitivanje AS-a (MEASURE 1) ocjenjivalo je 371 bolesnika, od kojih je 14,8% odnosno 33,4% istodobno koristilo MTX odnosno sulfasalazin.
AS Study 2 (MEASURE 2) evaluated 219 patients, of whom 11.9% and 14.2% used concomitant MTX or sulfasalazine, respectively.
Drugo ispitivanje AS-a (MEASURE 2) ocjenjivalo je 219 bolesnika, od kojih je 11,9% odnosno 14,2% istodobno uzimalo MTX odnosno sulfasalazin.
As such, tenofovir alafenamide exposures following administration of Genvoya are not expected to be further increased when used in combination with another P-gp inhibitor (e.g., ketoconazole).
Zbog toga se ne očekuje daljnji porast izloženosti tenofoviralafenamidu nakon primjene lijeka Genvoya u kombinaciji s drugim P-gp inhibitorom (npr. ketokonazolom).
As such, the following section outlines the adverse reactions of the individual components of Incresync (alogliptin/pioglitazone) as reported in their respective Summary of Product Characteristics.
S obzirom na to, u nastavku se navode nuspojave pojedinačnih sastojaka Incresynca (alogliptin/pioglitazon) kako su navedene u Sažetku opisa svojstava lijeka svakoga od njih.
As such, the following section outlines the adverse reactions of the individual components of Vipdomet (alogliptin/metformin) as reported in their respective Summary of Product Characteristics.
S obzirom na to, u nastavku se navode nuspojave pojedinačnih sastojaka Vipdometa (alogliptin/metformin) kako su navedene u Sažetku opisa svojstava lijeka svakoga od njih.
As such, the oral dexamethasone dose should be reduced by approximately 50% when co-administered with Akynzeo (see section 4.2).
S obzirom na to, doza peroralnog deksametazona treba biti smanjena za otprilike 50% kada se primjenjuje istovremeno s Akynzeom (vidjeti dio 4.2).
as support to stitching during surgery on the blood vessels;
Djeluje također kao podrška šavovima tijekom operacije krvnih žila;
As systemic exposure is low with tacrolimus ointment, the high binding of tacrolimus (> 98.8%) to plasma proteins is considered not to be clinically relevant.
Budući da je sistemska izloženost takrolimusu iz masti niska, smatra se da visoka stopa vezanja takrolimusa za proteine plazme (> 98,8%) nije klinički značajan.
As systemic exposure to linaclotide is minimal, excretion in breast milk is not likely, although it has not been evaluated.
Budući da je sistemska izloženost linaklotidu minimalna, izlučivanje u majčino mlijeko nije vjerojatno, iako nije ispitivano.
As tacrolimus is a substance with low clearance, adjustments to the Advagraf dose regimen may take several days before steady state is achieved.
Budući da je takrolimus tvar s niskim klirensom, nakon prilagodbe režima doziranja Advagrafa može proći i nekoliko dana prije nego što se postigne ravnotežna koncentracija.
As tacrolimus is a substance with low clearance, adjustments to the Envarsus dose regimen may take several days before steady state is achieved.
Budući da je takrolimus tvar s niskim klirensom, nakon prilagodbe režima doziranja Envarsusa može proći i nekoliko dana prije nego se postigne stanje dinamičke ravnoteže.
As tacrolimus is a substance with low clearance, it may take several days after adjustments to the Modigraf dose regimen before steady state is achieved (see below under “Therapeutic drug monitoring” and section 5.2).
Budući da je takrolimus tvar s niskim klirensom, može biti potrebno i nekoliko dana nakon prilagodbe režima doziranja Modigrafa prije nego što se postigne stanje dinamičke ravnoteže (vidjeti niže pod “Praćenje terapijske razine lijeka” i dio 5.2).
As tacrolimus treatment may be associated with hyperkalaemia, or may increase pre-existing hyperkalaemia, high potassium intake, or potassium-sparing diuretics (e.g. amiloride, triamterene or spironolactone) should be avoided (see section 4.4).
Budući da liječenje takrolimusom može dovesti do hiperkalijemije ili povisiti postojeću hiperkalijemiju, potrebno je izbjegavati visok unos kalija ili diuretike koji štede kalij (npr. amilorid, triamteren ili spironolakton) (vidjeti dio 4.4).
As tacrolimus treatment may be associated with hyperkalaemia, or may increase pre-existing hyperkalaemia, high potassium intake, or potassium-sparing diuretics (e.g. amiloride, triamterene, or spironolactone) should be avoided (see section 4.4).
Budući da liječenje takrolimusom može biti povezano s hiperkalijemijom ili pojačati već postojeću hiperkalijemiju, potrebno je izbjegavati uzimanje velikih količina kalija ili diuretika koji štede kalij (npr. amilorid, triamteren ili spironolakton) (vidjeti dio 4.4).
As tacrolimus treatment may be associated with hyperkalaemia, or may increase pre-existing hyperkalaemia, high potassium intake, or potassium-sparing diuretics (e.g., amiloride, triamterene, or spironolactone) should be avoided (see section 4.4).
Budući da liječenje takrolimusom može dovesti do hiperkalijemije ili povisiti postojeću hiperkalijemiju, potrebno je izbjegavati visok unos kalija ili diuretike koji štede kalij (npr. amilorid, triamteren ili spironolakton) (vidjeti dio 4.4).
As Tarceva seems to be more effective in patients with pancreatic cancer who develop a rash, treatment should be re-assessed after four to eight weeks if no rash has developed.
Budući da se čini da je lijek Tarceva djelotvorniji u bolesnika s rakom gušterače kod kojih se razvio osip, terapiju je potrebno ponovno preispitati nakon četiri do osam tjedana ako se osip nije razvio.
As telbivudine is a nucleoside analogue, this risk cannot be excluded.
Budući da je telbivudin nukleozidni analog, rizik se ne može isključiti.
As thalidomide is found in semen, male patients must use condoms during treatment and for 1 week after dose interruption and/or cessation of treatment if their partner is pregnant or is of childbearing potential not using effective contraception.
S obzirom na činjenicu da se talidomid može naći u spermi, muški bolesnici moraju upotrebljavati prezervative tijekom liječenja i 1 tjedan nakon prekida liječenja i/ili završetka liječenja, ako je njihova partnerica trudna ili je u reproduktivnoj dobi, a ne upotrebljava djelotvornu kontracepciju.
As thalidomide is found in semen, male patients must use condoms during treatment and for 1 week after dose interruption and/or cessation of treatment when having sexual intercourse with a pregnant woman or with a woman of childbearing potential who is not using effective contraception.
Budući da se talidomid može naći u spermi, muški bolesnici moraju upotrebljavati prezervative tijekom liječenja i 1 tjedan nakon prekida i/ili prestanka liječenja kada imaju spolne odnose s trudnicom ili ženom u reproduktivnoj dobi koja ne upotrebljava djelotvornu metodu kontracepcije.
As thalidomide is found in semen, male patients taking thalidomide must meet the following conditions:
S obzirom na činjenicu da se talidomid može naći u spermi, muški bolesnici koji uzimaju talidomid moraju ispunjavati sljedeće uvjete:
As the administration system contains electromechanical parts and a used needle, the administration system must not be disposed of in household waste.
Budući da sustav za primjenu sadrži elektromehaničke dijelove i upotrijebljenu iglu, ne smije se odložiti u kućni otpad.
As the amount given depends on the individual’s bodyweight, the doctor will need to adjust the dose as patient’s weight changes, particularly in growing children.
Budući da količina koja se primjenjuje ovisi o tjelesnoj težini pojedinca, liječnik treba prilagoditi dozu ovisno o promjenama u tjelesnoj težini bolesnika, posebice u djece u razvoju.
As the amount of capsaicin released from the patch per hour is proportional to the surface area of application, this amounts to an estimated total maximum possible dose for a 1000 cm2 area of application of approximately 7 mg.
Kako je količina kapsaicina oslobođenog iz flastera tijekom jednog sata proporcionalna površini područja primjene, procjenjuje se da najveća ukupna moguća doza za područje primjene od 1000 cm2 iznosi približno 7 mg.
As the animal swallows, the administration tool will move easily over the base of the tongue.
Nakon što životinja počne s gutanjem, sustav za primjenu će lagano kliznuti preko korijena jezika.
As the benefit observed in patients with 4+ nodes was not statistically significant on DFS and OS, the positive benefit/risk ratio for TAC patients with 4+ nodes was not fully demonstrated at the final analysis.
S obzirom na to da korist liječenja uočena u bolesnika s 4 i više pozitivnih limfnih čvorova nije bila statistički značajna u pogledu DFS i OS, pozitivan omjer rizika i koristi TAC liječenja u bolesnika s 4 i više pozitivnih limfnih čvorova nije potpuno dokazan u konačnoj analizi rezultata studije.
As the body breaks down protein after eating waste nitrogen, in the form of ammonia, accumulates because the body cannot eliminate it.
Nakon što se bjelančevine unesene hranom u tijelu razgrade, suvišni se dušik nakuplja u organizmu u obliku amonijaka jer ne može biti izlučen.
As the cardiovascular risk of cyclooxygenase-2 (COX-2) specific inhibitors may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used.
Budući da se kardiovaskularni rizik specifičnih inhibitora ciklooksigenaze-2 (COX-2) može povećavati s dozom i trajanjem izloženosti, mora ih se primjenjivati u najnižoj učinkovitoj dnevnoj dozi u što kraćem trajanju.
As the cardiovascular risk of cyclooxygenase-2 (COX-2) specific inhibitors may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used.
Budući da se kardiovaskularni rizik specifičnih inhibitora ciklooksigenaze-2(COX-2) može povećavati s dozom i trajanjem izloženosti, mora ih se primjenjivati u najnižoj učinkovitoj dnevnoj dozi u što kraćem trajanju.
As the clinical relevance of this increase in exposure is unclear, co-administration of potent inhibitors of P-gp, such as cyclosporine, ketoconazole, erythromycin, clarithromycin, verapamil, dronedarone and amiodarone is not recommended (see section 4.4 and 5.2).
Budući da klinička važnost ovog povećanja izloženosti nije jasna, ne preporučuje se istovremena primjena jakih inhibitora P-gp-a, kao što su ciklosporin, ketokonazol, eritromicin, klaritromicin, verapamil, dronedaron i amiodaron (vidjeti dijelove 4.4 i 5.2).
As the company had submitted the additional information requested, the ‘exceptional circumstances’ ended on 21 September 2009.
Budući da je tvrtka dostavila dodatne zatražene informacije, „iznimne okolnosti” prestale su 21. rujna 2009.
As the company had supplied the additional information requested at the time of authorisation, the ‘exceptional circumstances’ ended on 26 August 2013.
Nakon što je tvrtka dostavila dodatne informacije zatražene u vrijeme odobenja, „iznimne okolnosti" prestale su postojati 26. kolovoza 2013.
As the company had supplied the additional information requested, the ‘exceptional circumstances’ ended on 12 August 2010.
Budući da je tvrtka dostavila dodatne zatražene informacije, „iznimne okolnosti” prestale su 12. kolovoza 2010.
As the company had supplied the additional information requested, the ‘exceptional circumstances’ ended on 16 December 2015.
Budući da je tvrtka dostavila dodatne zatražene informacije, „iznimne okolnosti” prestale su 16. prosinca 2015.
As the company had supplied the additional information requested, the ‘exceptional circumstances’ ended on 17 January 2014.
Budući da je tvrtka dostavila dodatne zatražene informacije, „iznimne okolnosti” su završene 17. siječnja 2014.
As the company had supplied the additional information requested, the ‘exceptional circumstances’ ended on 19 March 2012.
Budući da je tvrtka dostavila dodatne zatražene informacije, „iznimne okolnosti” su ukinute dana 19. ožujka 2012.
As the company had supplied the additional information requested, the ‘exceptional circumstances’ ended on 20 July 2015.
Tvrtka je dostavila dodatne zatražene informacije, tako da je dodano „u iznimnim okolnostima” dana 20. srpnja 2015
As the company had supplied the additional information requested, the ‘exceptional circumstances’ ended on 27 May 2015.
Budući da je tvrtka dostavila dodatne zatražene informacije, „iznimne okolnosti” prestale su 27. svibnja 2015.
As the company has supplied the additional information necessary, the authorisation has been switched from conditional to full approval.
Budući da je tvrtka dostavila dodatne potrebne informacije, odobrenje za stavljanje lijeka u promet promijenjeno je iz uvjetnog odobrenja u potpuno odobrenje.
As the company has supplied the additional information necessary, the authorisation has been switched from conditional to full approval.
Budući da je tvrtka dostavila potrebne dodatne informacije, odobrenje za stavljanje lijeka u promet promijenjeno je iz uvjetnog odobrenja u potpuno odobrenje.
As the company has supplied the additional information necessary, the authorisation has been switched from conditional to full approval.
S obzirom da je farmaceutska tvrtka dostavila potrebne dodatne podatke o lijeku, status odobrenja je promijenjen iz uvjetovanog u potpuno.
As the dosage for each indication is given by body weight and adjusted to the clinical outcome of the above mentioned conditions, the dosage in children is not considered to be different to that of adults.
Doziranje u djece ne razlikuje se od doziranja u odraslih osoba jer se doza također određuje ovisno o tjelesnoj težini djeteta i kliničkom ishodu gore navedenih stanja i bolesti.
As the dose is given by body weight and adjusted to the clinical outcome of the above mentioned conditions, the dose in the elderly population is not considered to be different from that of adults.
Doza u starijoj populaciji ne smatra se različitom od one u odraslih budući da se daje na temelju tjelesne težine te je prilagođena kliničkom odgovoru gore navedenih uvjeta.