natgillin/translations-raw huggingface dataset:
The experience in the randomised, uncontrolled phase (year 2) of the ADVANCE study and in the 2 year safety extension study ATTAIN was consistent with the experience in the 1 year placebo-controlled phase of the ADVANCE study.
Iskustvo u randomizirnoj, nekontroliranoj fazi (2. godina) ADVANCE ispitivanja i u 2 godine produžetka ispitivanja sigurnosti ATTAIN, bilo je u skladu s iskustvom u 1. godini placebom-kontrolirane faze ADVANCE ispitivanja.
The experience of OPTISON in severely ill patients is limited
Iskustvo primjene lijeka OPTISON kod teško bolesnih pacijenata je ograničeno.
The experience with dalbavancin in elderly is limited: 276 patients ≥ 75 years of age were included in the Phase 2/3 clinical studies, of which 173 received dalbavancin.
Iskustvo s dalbavancinom kod starijih osoba je ograničeno: 276 bolesnika ≥ 75 godina bilo je uključeno u klinička ispitivanja faze 2/3, od kojih je 173 primilo dalbavancin.
The experience with Invirase in adults over 60 years is limited.
Iskustvo s primjenom lijeka Invirase u odraslih osoba starijih od 60 godina je ograničeno.
The experience with lacosamide in elderly patients with epilepsy is limited.
Iskustvo s lakozamidom kod starijih bolesnika s epilepsijom je ograničeno.
The expiration date and time have passed.
je istekao datum i vrijeme roka valjanosti
the expiration date has passed.
je istekao rok valjanosti.
the expiration date has passed; it has been frozen, even if it has now thawed (syringe only).
im je istekao rok valjanosti; su bile zamrznute, čak i ako su sada odmrznute (samo štrcaljka).
The expiration date refers to the last day of the month.
Rok valjanosti odnosi se na zadnji dan navedenog mjeseca.
The expiry date can be found on the ORENCIA carton and on each syringe.
Datum isteka roka valjanosti pronaći ćete na kutiji lijeka ORENCIA i na svakoj štrcaljki.
the expiry date has not passed
da nije istekao rok valjanosti
The expiry date has passed.
Rok valjanosti je prošao.
The expiry date is printed after ‘EXP’ on the outer carton, on the vial, on the vial adapter and on the pre-filled syringe.
Rok valjanosti otisnut je iza „Rok valjanosti“ na kutiji, bočici, nastavku za bočicu i napunjenoj štrcaljki.
The expiry date is printed after “EXP” on the outer carton, on the vial, on the vial adapter, and on the prefilled syringe.
Rok valjanosti otisnut je iza ‘Rok valjanosti’ na kutiji, bočici, nastavku za bočicu i napunjenoj štrcaljki.
The expiry date is the last day of the month indicated.
Rok valjanosti odnosi se na zadnji dan u mjesecu.
The expiry date printed on the label has passed the last day of the month shown.
Ukoliko je rok valjanosti otisnut na etiketi istekao, odnosno prošao je posljednji dan navedenog mjeseca
The expiry date printed on the label has passed the last day of the month shown.
Ukoliko je rok valjanosti otisnut na naljepnici istekao, odnosno ako je prošao posljednji dan navedenog mjeseca.
The expiry date refers to the last day of that month
Datum isteka roka trajanja odnosi se na zadnji dan tekućeg mjeseca.
The expiry date refers to the last day of that month,
Rok valjanosti odnosi se na zadnji dan navedenog mjeseca.
The expiry date refers to the last day of that month.
Datum isteka roka valjanosti odnosi se na zadnji dan tog mjeseca.
The expiry date refers to the last day of the month shown.
Rok valjanosti odnosi se na zadnji dan navedenog mjeseca.
The expiry dates refers to the last day of that month.
Rok valjanosti odnosi se na zadnji dan navedenog mjeseca.
The exploratory analyses of covariates with information in only a subset of patients suggested that patients with greater shed HER2-ECD level had faster nonlinear clearance (lower Km) (P  0.001).
Eksploracijske analize kovarijanti na temelju podataka prikupljenih samo u jednoj podskupini bolesnika pokazali su da su bolesnici s višom razinom odcjepljivanja HER2-ECD-a imali brži nelinearni klirens (niži Km) (P<0,001).
The exposed pregnancies showed no adverse reactions to cholic acid and resulted in normal, healthy children.
U trudnoćama izloženim lijeku nisu se pojavile nuspojave na kolnu kiselinu i rezultirale su normalnom, zdravom djecom.
The exposure (AUC) to telaprevir increased slightly greater than proportionally to the dose after single-dose administration of 375 up to 1,875 mg with food, possibly due to saturation of metabolic pathways or efflux transporters.
Nakon primjene jednokratne doze od 375 do 1875 mg uz obrok izloženost (AUC) telapreviru povećala se malo više nego proporcionalno u odnosu na dozu, vjerojatno zbog saturacije metaboličkih puteva ili transportnih proteina.
The exposure adjusted incidence rate (expressed per 100 person-years) remained stable over the treatment duration.
Stopa incidencije prema izloženosti (izraženo kao 100 osoba-godina) ostala je stabilna tijekom cijelog trajanja liječenja.
The exposure camparison across species indicates that exposures that did not elicit adverse effects in the 6- and 9-month toxicity studies in rats and dogs, respectively, were similar to or slightly exceeding the exposure in humans after multiple dosing of 500 mg.
Usporedba izloženosti među vrstama upućuje da su izloženosti koje nisu izazvale štetne učinke u 6-mjesečnom i 9-mjesečnom ispitivanju toksičnosti u štakora i u pasa bile slične ili nešto veće u odnosu na izloženost u ljudi nakon višekratnih doza od 500 mg.
The exposure in rats at the NOAEL was less to only slightly higher than the human exposure based on the AUC.
Izloženost u štakora pri razini na kojoj nije opažen štetni učinak (NOAEL) bila je manja do samo nešto viša u odnosu na ljudsku izloženost na temelju AUC.
The exposure increased three-fold when the dose of hydrocortisone modified-release increased from 5 mg to 20 mg.
Izloženost se povećala trostruko kada se doza hidrokortizona s prilagođenim oslobađanjem povećala s 5 mg na 20 mg.
The exposure of budesonide and formoterol may be increased in patients with liver disease.
Izloženost budezonidu i formoterolu može se povećati u bolesnika s bolešću jetre.
The exposure of ivacaftor increased approximately 2.5- to 4-fold when given with food containing fat.
Izloženost ivakaftoru povećala se približno 2,5 do 4 puta kad se davao s hranom bogatom mastima.
The exposure of ivacaftor is similar between healthy adult volunteers and patients with CF.
Izloženost ivakaftoru slična je u zdravih odraslih ispitanika i bolesnika s cističnom fibrozom.
The exposure of ivacaftor will be
Izloženost ivakaftoru će se smanjiti, što
The exposure of metabolites M-2 (N-oxide) and M-5 (N-oxide and N-desmethyl) is higher when regorafenib is given with a low fat breakfast as compared to fasting condition and lower when given with a high fat meal as compared to fasting condition.
Izloženost metabolita M-2 (N-oksid) i M-5 (N-oksid i N-dezmetil) viša je kad se regorafenib primjenjuje s doručkom s niskim udjelom masti u odnosu na stanje natašte i niža kad se daje s punomasnim obrokom u usporedbi sa stanjem natašte.
The exposure of the active metabolite and the plasma DPP4 activity inhibition over a dose interval were not influenced by rifampicin (see section 4.4).
Rifampicin nije utjecao na izloženost aktivnom metabolitu ni inhibiciju aktivnosti DPP-4 u plazmi tijekom doznog intervala (vidjeti dio 4.4).
The exposure of the active metabolite and the plasma DPP4 activity inhibition over a dose interval were not influenced by rifampicin (see section 4.4).
Rifampicin nije utjecao na izloženost aktivnom metabolitu ni inhibiciju aktivnosti DPP-4 u plazmi tijekom intervala doziranja (vidjeti dio 4.4).
The exposure of the O-desmethyl metabolite was several-fold increased in patients with moderate and severe renal impairment.
Izloženost O-dezmetilnom metabolitu nekoliko je puta povećana kod bolesnika s umjerenim i teškim oštećenjem bubrega.
The exposure to M1 increases with the administered dose of insulin glargine.
Izloženost metabolitu M1 raste s primijenjenom dozom inzulina glargina.
The exposure to M1 increases with the administered dose of Lantus.
Izloženost metabolitu M1 raste s primijenjenom dozom lijeka Lantus.
The exposure to M1 increases with the administered dose of Toujeo.
Izloženost metabolitu M1 raste s primijenjenom dozom lijeka Toujeo.
The exposure to rivastigmine and its metabolites was approximately equivalent to human exposure with highest doses of rivastigmine capsules and transdermal patches.
Izloženost rivastigminu i njegovim metabolitima bila je približno jednaka izloženosti u ljudi pri najvišim dozama kapsula i transdermalnih flastera s rivastigminom.
The exposure to selexipag and its active metabolite is increased in subjects with moderate hepatic impairment (Child-Pugh class B; see section 5.2).
Izloženost seleksipagu i njegovim aktivnim metabolitima je povećana u ispitanika s umjerenim oštećenjem funkcije jetre (Child-Pugh stadij B; vidjeti dio 5.2).
The exposure to vortioxetine increased 2.3-fold for area under the curve (AUC) when vortioxetine 10 mg/day was co-administered with bupropion (a strong CYP2D6 inhibitor 150 mg twice daily) for 14 days in healthy subjects.
Izloženost vortioksetinu povećala je površinu ispod krivulje (AUC) 2,3 puta kada je vortioksetin 10 mg/dan bio istodobno primijenjen s bupropionom (snažnim inhibitorom CYP2D6) 150 mg dvaput dnevno tijekom 14 dana u zdravih ispitanika.
The exposure-adjusted rate was 0.06 events per 100 patient-years.
Stopa prilagođena izloženosti bila je 0,06 događaja na 100 bolesnik- godina.
The exposure-adjusted rates of rash (all causality) were 10.9, 4.2, and 3.8 per 100 patient-years (PYR), respectively; and for drug-related rash were 2.4, 1.1, and 2.3 per 100 PYR, respectively.
dok su za osip povezan s lijekom u te tri skupine stope iznosile 2,4; 1,1 odnosno 2,3 na 100 bolesnik- godina.
the exposures of these antidepressants,
izloženost tim antidepresivima, što može
The expression of CYP3A and CYP3A4 may vary by as much as 40 fold due to genetic polymorphism.
Ekspresija CYP3A i CYP3A4 može varirati do 40 puta zbog genetskog polimorfizma.
The extent and degree of distribution to various body compartments have not been fully studied.
Opseg i stupanj distribucije u pojedinim tjelesnim odjeljcima nije u potpunosti proučen.
The extent and time course of seroconversion were similar in patients with prior toxin A exposure and those who were toxin A naïve, and between toxin A resistant and toxin A responsive patients.
Opseg i tijek serokonverzije bili su slični u bolesnika s prethodnim izlaganjem toksinu A i onih koji prije nisu primali toksin A te između bolesnika rezistentnih na toksin A i onih s odgovorom na toksin A.
The extent of absorption is not affected by formula feeding but tmax may be prolonged.
Prehrana formulom ne utječe na opseg apsorpcije, ali tmax može biti produljen.
The extent of available data is not sufficient to conclude that growth inhibition due to Pegasys exposure is always reversible.
Podaci iz dugoročnog praćenja nisu dovoljni kako bi se zaključilo da je zastoj rasta uslijed izloženosti lijeku Pegasys uvijek reverzibilan.
The extent of exposure and the maximal plasma concentration are proportional to the dose between 6 and 20 mg/m2.
Stupanj izloženosti i najveća moguća koncentracija u plazmi razmjerni su dozi od 6 do 20 mg/m2.
The extent of exposure was similar following a high fat meal and fasted state while tmax was delayed from 1.5 to 3 hours (topotecan lactone) and from 3 to 4 hours (total topotecan).
Razina izloženosti bila je slična nakon obroka bogatog mastima i nakon posta dok je tmax bio odgođen s 1,5 na 3 sata (topotekan lakton) i s 3 na 4 sata (ukupni topotekan).
The extent of increase depends on
Opseg povećanja ovisi o vremenu
The extent of lamivudine and zidovudine absorption (AUC∞) and estimates of half-life following administration of lamivudine/zidovudine with food were similar when compared to fasting subjects, although the rates of absorption (Cmax, tmax) were slowed.
Opseg apsorpcije lamivudina i zidovudina (AUC) i procijenjeni poluvijek nakon primjene lamivudina/zidovudina s hranom bili su slični vrijednostima dobivenima nakon primjene lamivudina/zidovudina bolesnicima natašte, iako se brzina apsorpcije (Cmax,tmax) smanjila.
The extent of lamivudine and zidovudine absorption (AUC) and estimates of half-life following administration of Combivir with food were similar when compared to fasting subjects, although the rates of absorption (Cmax, tmax) were slowed.
Opseg apsorpcije lamivudina i zidovudina (AUC) i procijenjeni poluvijek nakon primjene Combivira s hranom bili su slični vrijednostima dobivenima nakon primjene Combivira bolesnicima natašte, iako se brzina apsorpcije (Cmax,tmax) smanjila.
The extent of percutaneous absorption of topical medications is determined by many factors including the integrity of the epidermal barrier.
Stupanj perkutane apsorpcije topikalno primijenjenih lijekova određuje se mnogim čimbenicima koji uključuju i integritet epidermalne barijere.
The extent of Praxbind’s benefit depends on the patient’s overall health, the severity of bleeding and the location of bleeding.
Stupanj koristi lijeka Praxbind ovisi o općem zdravlju bolesnika, te o ozbiljnosti i mjestu krvarenja.
The extent of protection that Rotarix might provide against other rotavirus strains that have not been circulating in clinical trials is currently unknown.
Trenutno nije poznato opseg zaštite koju Rotarix može pružiti protiv drugih sojeva rotavirusa koji nisu cirkulirali u kliničkim studijama.
The extent of protein binding of hydroxycarbamide is unknown.
Opseg vezanja hidroksikarbamida za proteinenije poznat .
The extent of serum protein binding is independent of drug concentration over the test range of 0.1–10 g Starlix/ml.
Opseg vezanja za serumske proteine ne ovisi o koncentraciji lijeka u ispitanom rasponu od 0,1-10 g Starlixa/ml.
The extent of thalidomide metabolism by the liver cytochrome P450 system is minimal and intact thalidomide is not excreted by the kidney.
Opseg metabolizma talidomida posredovan sustavom citokroma P450 minimalan je, a nepromijenjeni se talidomid ne izlučuje bubrezima.
The extent to which these outcomes might apply to the administration of recombinant human erythropoietin to patients with cancer, treated with chemotherapy to achieve haemoglobin concentrations less than 13 g/dl, is unclear because few patients with these characteristics were included in the data reviewed.
Nije jasan opseg do kojeg se ti ishodi mogu primijeniti na davanje rekombinantnog humanog eritropoetina bolesnicima s karcinomom, liječenih kemoterapijom, da bi se postigle koncentracije hemoglobina niže od 13 g/dl, jer je samo nekoliko bolesnika s tim karakteristikama bilo uključeno u reviziju podataka.
The extent to which these outcomes might apply to the administration of recombinant human erythropoietin to patients with cancer, treated with chemotherapy to achieve haemoglobin concentrations less than 13 g/dl, is unclear because few patients with these characteristics were included in the data reviewed.
Nije jasan opseg do kojeg se ti ishodi mogu primijeniti na davanje rekombinantog ljudskog eritropoetina bolesnicima s rakom, liječenih kemoterapijom da bi se postigle koncentracije hemoglobina niže od 13 g/dl, jer je malo bolesnika s tim karakteristikama bilo uključeno u obrađenim podacima.
The extent to which these outcomes might apply to the administration of recombinant human erythropoietin to patients with cancer, treated with chemotherapy to achieve haemoglobin concentrations less than 13 g/dl, is unclear because few patients with these characteristics were included in the data reviewed.
U kojoj mjeri se ovi učinci mogu pripisati primjeni rekombinantnog humanog eritropoetina kod bolesnika s malignim bolestima liječenih kemoterapijom radi postizanja koncentracije hemoglobina manjeg od 13 g/dl je nejasna jer je samo nekoliko bolesnika s takvim karakteristikama bilo uključeno u podatke koji su analizirani.
The extent varies with the patient’s body weight (increased in light body weight patients and decreased in heavy body weight patients) but clinical outcome is consistent with that observed in intravenous treated patients.
U kojoj će se mjeri izloženost promijeniti ovisi o tjelesnoj težini bolesnika (povećava se u bolesnika male tjelesne težine, a smanjuje u bolesnika velike tjelesne težine), no klinički je ishod sukladan onome primijećenome u bolesnika liječenih intravenskom formulacijom.
the external
vanjskog
The extractable volume is not to be used in total.
Ukupni volumen koji je moguće izvući iz napunjene štrcaljke ne smije se u potpunosti primijeniti.
The extractable volume of the syringe (90 microlitres) is not to be used in total.
Ne treba primijeniti cjelokupni volumen koji se može istisnuti iz štrcaljke (90 mikrolitara).
The extractable volume of the vial (100 microlitres) is not to be used in total.
Ne treba primijeniti cjelokupni volumen koji se može istisnuti iz štrcaljke (90 mikrolitara).
The eyelids are kept closed over the insert with a steri-strip band.
Preko umetka vjeđe treba držati zatvorene ljepljivom trakom (Steri- strip).
The eyes should be protected by a suitable eye lubricant.
Oči treba zaštititi prikladnim lubrikantom.
The eyes should be protected by a suitable eye lubricant.
Oči treba zaštititi prikladnim očnim lubrikansom.
The Fab domain of rituximab binds to the CD20 antigen on B lymphocytes and the Fc domain can recruit immune effector functions to mediate B cell lysis.
Fab domena rituksimaba veže se na antigen CD20 na B-limfocitima, a Fc domena može pokrenuti funkcije imunog efektora na posredovanje lize B-stanice.
The face to face training material, including the educational video, shall contain the following key messages:
Materijal za individualnu obuku, uključujući edukacijski video, obuhvaća sljedeće ključne poruke:
The FACT study showed the statistically significant superiority of both ADENURIC 80 mg and ADENURIC 120 mg QD treatment arms versus the conventionally used dose of allopurinol 300 mg treatment arm in reducing and maintaining sUA below 6 mg/dL (357 µmol/L).
Ispitivanje FACT pokazalo je statistički značajnu superiornost liječenja, kako ADENURICOM 80 mg tako i ADENURICOM 120 mg jednom dnevno u odnosu na liječenje uobičajeno korištenim dozama alopurinola 300 mg, s obzirom na snižavanje razine mokraćne kiseline u serumu ispod 6 mg/dl (357 µmol/l).
The fact that Nexobrid may cause an allergic reaction, an increased tendency to bleed and severe local irritation and that patients should be monitored for signs or symptoms of these
Činjenica da NexoBrid može uzrokovati alergijsku reakciju, povećanu sklonost krvarenju i jaku lokalnu iritaciju te da bolesnike treba nadzirati na znakove ili simptome tih stanja
The fact that patients should be monitored for signs and symptoms of wound and systemic infections
Činjenica da bolesnike treba nadzirati i paziti na znakove i simptome infekcije rane i sistemskih infekcija
The fact that Ruconest is derived from milk of transgenic rabbits and contains trace of rabbit proteins (Host Related Impurities, HRI).
Podatak da je Ruconest dobiven iz mlijeka transgeničnih kunića i da sadrži tragove proteina kunića (nečistoće vezane uz domaćina).
The factor VIII/von Willebrand factor complex consists of 2 molecules (factor VIII and von Willebrand factor) with different physiological functions.
Kompleks faktora VIII/von Willebrandovog faktora sastoji se od 2 molekule (faktora VIII i von Willebrandovog faktora) s različitim fiziološkim funkcijama.
The factor XIII A-subunit in NovoThirteen is made by a method known as ‘recombinant DNA technology’: it is produced by yeast cells that have received the gene (DNA) which makes the cells able to produce it.
Faktor XIII podjedinica A u NovoThirteen proizvodi se metodom poznatom pod nazivom „tehnologija rekombinantne DNK”: proizvodi se iz stanica kvasca koji su primili gen (DNK) koji omogućuje stanicama da ga proizvode.
The falcon tube is placed in a plastic screw top container together with surgery materials (one sterile syringe of 1 ml, one 18G intravenous catheter and two pieces of Vicryl 6.0) and a temperature monitor.
Falcon epruveta nalazi se u spremniku s plastičnim navojnim vrhom zajedno s kirurškim materijalom (jedna sterilna štrcaljka od 1 ml, jedan intravenski kateter 18G i dva komada Vicryl 6.0) te kontrolnim monitorom temperature.
The Fampyra dose was 10mg BID.
Doza Fampyre je bila 10 mg dva puta na dan.
The faster onset of action compared to soluble human insulin is maintained regardless of injection site.
Početak djelovanja brži je nego kod topljivog humanog inzulina bez obzira na mjesto injiciranja.
The fatal events included those due to progression of disease; however a causal relationship cannot be excluded.
Smrtni slučajevi uključivali su one zbog progresije bolesti; međutim, ne može se isključiti uzročno- posljedična veza.
The favorable overall response rates at the end of caspofungin therapy were similar in the 2 treatment groups: 72 % (73/102) and 78 % (74/95) for the caspofungin 50-mg and 150-mg treatment groups, respectively (difference 6.3 % [95 % CI -5.9, 18.4]).
Povoljna ukupna stopa odgovora na kraju terapije kaspofunginom bila je slična u te 2 terapijske skupine: 72% (73/102) u skupini koja je primala kaspofungin u dozi od 50 mg i 78% (74/95) u skupini koja je primala kaspofungin u dozi od 150 mg (razlika 6,3% [95% CI, -5,9, 18,4]).
The favorable response rate, by indication, at the end of caspofungin therapy was as follows in the MITT analysis: 81 % (30/37) in invasive candidiasis, 50 % (5/10) in invasive aspergillosis, and 100 % (1/1) in esophageal candidiasis.
Prema MITT analizi stopa povoljnog odgovora na kraju terapije kaspofunginom prema indikaciji bila je prisutna u 81% (30/37) bolesnika s invazivnom kandidijazom, 50% (5/10) bolesnika s invazivnom aspergilozom i 100% (1/1) bolesnika s kandidijazom jednjaka.
The feed containing the oral powder should be provided as the sole ration for the periods recommended above.
Hrana za životinje izmiješana s praškom za peroralnu primjenu mora biti jedini obrok koji se daje svinjama u gore preporučenim razdobljima.
The feed containing the oral powder should be provided as the sole ration for the treatment periods recommended above.
Hranu koja sadrži oralni prašak treba isporučivati kao pojedinačnu porciju za prethodno preporučena razdoblja liječenja.
The feline calicivirus and feline panleucopenia virus vaccine strains can spread.
Navedeni sojevi mačjeg kalicivirusa i panleukopenije se mogu širiti.
The femoral condyle is the end of the thigh bone, which forms part of your knee.
Femoralni kondil je završetak natkoljenične kosti koji čini dio Vašeg koljena.
The fenofibrate plus Cholestagel group (64 patients) demonstrated a 10% reduction on LDL-C levels versus 2% increase for the fenofibrate group (65 patients).
U skupini koja je dobivala fenofibrat i Cholestagel (64 bolesnika) zabilježeno je sniženje vrijednosti LDL kolesterola od 10%, u usporedbi s porastom od 2% u skupini koja je dobivala samo fenofibrat (65 bolesnika).
The ferrets were challenged intranasally on day 35 with a high dose of either the clade 2 H5N1 virus A/Indonesia/05/2005 or the clade 1 H5N1 virus A/Vietnam/1203/2004 and monitored for 14 days.
35. dana tvorovima su intranazalno aplicirane visoke doze skupine virusa 2 H5N1 A/Indonesia/05/2005 ili skupine virusa 1 H5N1 A/Vietnam/1203/2004 te su praćeni 14 dana.
The fibrin clot becomes embedded in the Matrix which enables EVARREST to stick firmly to the surrounding tissue.
Fibrinski ugrušak ugrađuje se u matriks koji omogućava da se EVARREST čvrsto zalijepi na okolno tkivo.
The fibrin then aggregates (sticks together) and forms a fibrin clot that holds the gelatin sponge tightly to the wound surface, preventing bleeding and sealing the tissue.
Fibrin se zatim agregira (povezuje) i tvori ugruške fibrina koji fiksiraju želatinastu spužvu čvrsto za površinu rane, sprečavajući krvarenje i zatvarajući tkivo.