natgillin/translations-raw huggingface dataset:
This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collie or Old English Sheep dogs and related breeds or crossbreeds, to correctly administer the product as described under section 4.9; in particular, oral uptake by the recipient and/or other animals in close contact should be prevented. 
Ovaj proizvod sadrži moksidektin (makrociklički lakton), stoga je potreban oprez kod tretiranja kolija i staroengleskih ovčara te srodnih pasmina ili njihovih križanaca, da se ispravno primjeni proizvod kako je opisano u odjeljku 4.9; pogotovo je važno onemogućiti peroralni unos kod tretirane ili druge životinje u bliskom kontaktu.
If adult heartworm infection is diagnosed, the infection should be treated in accordance with current scientific knowledge. 
Ako se utvrdi invazija odraslim srčanim crvom , bolest treba tretirati sukladno s aktualnim znanstvenim spoznajama.
Place the tip of the pipette on the skin and squeeze the pipette firmly several times to empty its contents directly onto the skin. 
Stavite vrh pipete na kožu i stisnite čvrsto pipetu nekoliko puta da se sadržaj isprazni izravno na kožu.
Advocate should not enter water courses as this may be dangerous for fish and other aquatic organisms. 
Advocate ne treba odlagati u otvorene vode jer to može biti opasno za ribe i druge vodene organizme.
Laboratory studies with either imidacloprid or moxidectin in rats and rabbits have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. 
Laboratorijska ispitivanja s imidaklopridom ili moksidektinom kod štakora i kunića nisu dokazala nikakve teratogene, fetotoksične ili maternalnotoksične učinke.
0.4 ml, 1.0 ml, 2.5 ml and 4.0 ml per pipette. 
Veličine pakovanja 0,4 ml, 1,0 ml, 2,5 ml, i 4,0 ml pipete.
Studies evaluating the pharmacokinetic behaviour of moxidectin after multiple applications have indicated that steady state serum levels are achieved following approximately 4 consecutive monthly treatments in cats. 
Studije procjene farmakokinetike moksidektina nakon višekratnih aplikacija pokazale su da su stabilne razine u serumu postignute nakon 4 uzastopne aplikacije u mjesečnim intervalima kod mačaka.
Place the tip of the pipette on the skin and gently squeeze the pipette to expel a portion of its contents directly onto the skin. 
Stavite vrh pipete na kožu i nježno stisnite pipetu da biste istisnuli dio sadržaja izravno na kožu.
When replacing another heartworm preventative product in a heartworm prevention programme, the first treatment with Advocate must be given within 1 month of the last dose of the former medication. 
Kada se neki drugi proizvod za sprječavanje dirofilarioze zamjenjuje s Advocate-om, prvo tretiranje Advocate-om mora se primijeniti unutar mjesec dana od posljednje doze prethodnog veterinarsko-medicinskog proizvoda.
At each spot part the coat until the skin is visible. 
Na svakom mjestu razmaknite dlaku da koža bude vidljiva.
Reduction of microfilariae (skin worm) (D. repens) 
Redukcija mikrofilarija (potkožni crv) (D. repens)
One pipette of Advocate spot-on solution for small cats (0.4 ml) should be administered per animal. 
Jedna pipeta Advocate spot-on otopine za male mačke (0,4 ml) aplicira se jednoj životinji.
For ferrets: Do not use Advocate for large cats (0.8 ml) or Advocate for dogs (any size). 
Za afričke tvorove: ne primjenjivati Advocate za velike mačke (0,8 ml) ili Advocate za pse (bilo koja veličina).
Use of the product may result in transient pruritus in cats. 
Primjena proizvoda može izazvati prolazan svrbež kod mačaka.
In non-endemic areas there should be no risk of cats having heartworm. 
U ne-enzootskim područjima ne bi trebalo biti opasnosti od invazije mačaka srčanim crvom.
In very rare case the product may cause respiratory irritation in sensitive individuals. 
U vrlo rijetkim slučajevima proizvod može uzrokovati iritaciju respiratornog sustava kod osjetljivih pojedinaca.
Treatment should continue at regular monthly intervals until 1 month after the last exposure to mosquitoes. 
Tretiranje treba nastaviti u redovitim mjesečnim intervalima do 1 mjesec nakon posljednjeg izlaganja komarcima.
Therefore prior to treatment with Advocate, the advice provided in the section “SPECIAL WARNING(S)” should be considered. 
Stoga prije primjene Advocate-a potrebno je uzeti u obzir savjet iz odjeljka ”POSEBNA UPOZORENJA”.
Studies evaluating the pharmacokinetic behaviour of moxidectin after multiple applications have indicated that steady state serum levels are achieved following approximately 4 consecutive monthly treatments in dogs. 
Studije kojima se procjenjuje farmkokinetički učinak moksidektina nakon višekratnik aplikacija ukazale su na to da se stacionarno stanje razine u serumu postiže nakon približno 4 uzastopna mjeseca tretiranja kod pasa.
In endemic areas regular monthly application will prevent angiostrongylosis and patent infection with Angiostrongylus vasorum. 
U enzootskim područjima redovito tretiranje mjesečno spriječiti će angiostrongilozu i patentnu invaziju s Angiostrongylus vasorum.
As demodicosis is a multi-factorial disease, where possible, it is advisable to also treat any underlying disease appropriately. 
Budući da je etiologija demodikoze vrlo složena preporučuje, kada je to moguće istodobno liječiti osnovnu bolest.
For dogs up to 25 kg: 
Za pse do 25 kg:
The product may be administered throughout the year or at least 1 month before the first expected exposure to mosquitoes. 
Proizvod se može primjenjivati tokom cijele godine ili najkasnije 1 mjesec prije očekivanog prvog izlaganja komarcima.
White polypropylene unit dose pipette with screw cap. 
Bijela polipropilenska pipeta s pojedinačnom dozom i navojnim čepom.
Care should be taken that the contents of the pipette or the applied dose does not come into contact with the eyes or mouth of the recipient and/or other animals. 
Potreban je oprez da sadržaj pipete ili aplicirane doze ne dospije u dodir s očima ili ustima tretirane i/ili drugih životinja.
Advocate for large cats (> 4-8 kg) 
Advocate za velike mačke (> 4-8 kg)
The treatment of animals weighing less than 1 kg should be based on a benefit-risk assessment. 
Tretiranje životinja lakših od 1 kg trebalo bi temeljiti na procjeni koristi-rizika.
Use of the product may result in transient pruritus in dogs. 
Primjena proizvoda može izazvati prolazan svrbež pasa.
Prevention of spirocercosis (Spirocerca lupi) 
Prevencija spirocerkoze (Spirocerca lupi)
Then hold the pipette in an upright position, and twist and pull off cap. 
Držite pipetu u uspravnom položaju i odvrnite i skinite kapicu.
It is recommended that cats and ferrets living in, or travelling to areas endemic for heartworm are treated monthly with the product to protect them from heartworm disease. 
Preporučuje se mačke i afričke tvorove koji žive u enzootskim područjima dirofilarioze ili putuju u takva područja tretirati proizvodom jednom mjesečno čime ih se štiti od srčane dirofilarioze.
Oral uptake by Collie or Old English Sheep dogs and related breeds or crossbreeds should be prevented. 
Potrebno je spriječiti peroralni unos kod kolija ili staroengleskih ovčara i srodnih pasmina ili njihovih križanaca.
The product may, in rare cases, cause local hypersensitivity reactions. 
Proizvod može u rijetkim slučajevima uzrokovati lokalne reakcije preosjetljivosti.
Five times the recommended minimum dose applied at weekly intervals for 17 weeks was investigated in dogs aged over 6 months and tolerated with no evidence of adverse effects or undesirable clinical signs. 
Doze 5 puta veće od preporučenih aplicirane su u tjednim intervalima tijekom 17 tjedana kod pasa starijih od 6 mjeseci bez znakova štetnih učinaka ili nepoželjnih kliničkih simptoma.
For prevention of heartworm disease, the product must be applied at regular monthly intervals during the time of the year when mosquitoes (the intermediate hosts which carry and transmit heartworm larvae) are present. 
Za prevenciju invazije srčanim crvom, proizvod se mora primjenjivati u redovitim mjesečnim intervalima tijekom razdoblja godine kada se javljaju komarci (intermedijarni domaćini koji nose i prenose larve srčanog crva).
• the treatment of ear mite infestation (Otodectes cynotis), 
• liječenje infestacije ušnim šugarcima (Otodectes cynotis),
Advocate should not enter water courses as it has harmful effects on aquatic organisms: moxidectin is highly toxic to aquatic organisms. 
Advocate ne treba odlagati u otvorene vode jer to može biti opasno za vodene organizme: moksidektin je izrazito toksičan za vodene organizme.
There is limited experience on the use of the product in sick and debilitated animals, thus the product should only be used based on a benefit-risk assessment for these animals. 
Ograničeno je iskustvo u primjeni proizvoda kod bolesnih i slabih životinja, stoga bi se proizvod trebao primjenjivati na temelju procjene koristi-rizika kod tih životinja.
> 4-10 kg Advocate for medium dogs > 10-25 kg Advocate for large dogs > 25-40 kg Advocate for extra-large dogs > 40 kg appropriate combination of pipettes 
> 4-10 kg Advocate za srednje velike pse > 10-25 kg Advocate za velike pse > 25-40 kg Advocate za vrlo velike pse > 40 kg
Advocate for small dogs (≤ 4 kg) 
Advocate za male pse (≤ 4 kg)
Dogs infected with adult heartworms tolerated up to 5 times the recommended dose, every 2 weeks for 3 treatments, without any adverse effects. 
Psi invadirani s odraslim srčanim crvima tolerirali su peterostruku preporučenu dozu svaka 2 tjedna tri puta, bez nepovoljnih učinaka.
0.4 ml and 0.8 ml per pipette. 
Veličine pakovanja 0,4 ml i 0,8 ml pipete.
Treatment of ear mite infestation (Otodectes cynotis) 
Suzbijanje ušnih šugaraca (Otodectes cynotis)
Heartworm prevention (Dirofilaria immitis) 
Sprječavanje dirofilarioze (Dirofilaria immitis)
In very rare cases the product may cause skin sensitisation or transient skin reactions (for example numbness, irritation or burning/tingling sensation). 
U vrlo rijetkim slučajevima proizvod može izazvati senzibilizaciju kože ili prolazne kožne reakcije (na primjer utrnulost, iritaciju ili osjećaj žarenja/ trnci).
Moxidectin is active against larval stages of Dirofilaria immitis (L1, L3, L4) and Dirofilaria repens (L1, L3). 
Moksidektin je učinkovit protiv larvalnih stadija Dirofilaria immitis (L1, L3, L4) i Dirofilaria repens
The product may in very rare cases cause at the application site a sensation resulting in transient behavioural changes such as lethargy, agitation, and inappetence. 
Proizvod može u rijetkim slučajevima na mjestu aplikacije uzrokovati povećanu osjetljivost što uzrokuje promjene u ponašanju kao što su potištenost, uzbuđenost i gubitak apetita.
Moxidectin is active against larval stages (L3, L4) of Dirofilaria immitis. 
Moksidektin je učinkovit protiv larvalnih stadija (L3, L4) Dirofilaria immitis.
In case of accidental oral uptake, symptomatic treatment should be administered. 
U slučaju nehotičnog peroralnog unosa, potrebno je primijeniti simptomatsku terapiju.
No interactions between Advocate and routinely used veterinary medicinal products or medical or surgical procedures have been observed. 
Nisu poznate interakcije između Advocatea i često korištenih veterinarsko-medicinskih proizvoda te medicinskih ili kirurških zahvata.
People with a known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. 
Osobe preosjetljive na benzilni alkohol, imidakloprid ili moksidektin trebaju oprezno rukovati proizvodom.
• the treatment and prevention of flea infestation (Ctenocephalides felis), • the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis). 
• liječenje i prevenciju infestacije buhama (Ctenocephalides felis), • prevenciju invazije srčanim crvom (L3 i L4 ličinke Dirofilaria immitis).
The product should be administered monthly for four consecutive months. 
Proizvod treba aplicirati jednom mjesečno tijekom 4 uzastopna mjeseca.
Therefore, it may be necessary to combine Advocate treatment with treatments aimed at breaking the flea life cycle in the surroundings. 
Stoga, ponekad je potrebno kombinirati primjenu Advocate-a s tretiranjem okoliša usmjerenim na prekidanje razvojnog ciklusa buha u okolišu.
The drug has a persistent action and protects dogs for 4 weeks after a single application against reinfection with the following parasites: Dirofilaria immitis, Dirofilaria repens, Angiostrongylus vasorum. 
Veterinarsko-medicinski proizvod ima perzistentno djelovanje i nakon jedne aplikacije štiti pse tijekom 4 tjedna od reinfestacije sljedećim parazitima: Dirofilaria immitis, Dirofilaria repens,
Flea treatment and prevention (Ctenocephalides felis) One treatment prevents further flea infestation for 4 weeks. 
Suzbijanje i sprječavanje infestacije buhama (Ctenocephalides felis) Jednokratnim tretmanom sprječava se nova infestacija buhama sljedeća 4 tjedna.
Pack sizes: 0.4 ml, 1.0 ml, 2.5 ml and 4.0 ml per pipette; blister packs containing 1, 2, 3, 4, 6, 9, 12, 21 or 42 unit dose pipettes. 
Veličina pakiranja: 0,4 ml, 1,0 ml, 2,5 ml i 4,0 ml pipete; blister pakiranja sadržavaju 1, 2, 3, 4, 6, 9, 12, 21 i 42 pipete.
After accidental oral ingestion or overdose, neurological signs (most of which are transient) such as ataxia, generalised tremors, ocular signs (dilated pupils, little pupillary reflex, nystagmus), abnormal respiration, salivation and vomiting may occur in very rare cases. 
Nakon nehotičnog peroralnog unosa ili predoziranja, neurološki simptomi (od kojih je većina prolazna) kao što su ataksija, generalizirani tremori, očni simptomi (raširene zjenice, slab pupilarni refleks, nistagmus), abnormalno disanje, slinjenje i povraćanje mogu se javiti u vrlo rijetkim slučajevima.
• the treatment and prevention of flea infestation (Ctenocephalides felis), 
• liječenje i prevenciju infestacije buhama (Ctenocephalides felis),
If skin or eye symptoms persist, or the product is accidentally swallowed, seek medical advice immediately and show the package leaflet or label to the physician. 
Ako kožni ili očni simptomi potraju, ili se proizvod nehotično proguta, potražite odmah liječnički savjet i pokažite uputu ili etiketu liječniku.
For large cats weighing between 4 kg and 8 kg. 
Za velike mačke od 4 do 8 kg.
• the reduction of circulating microfilariae (Dirofilaria repens), 
• redukciju cirkulirajućih mikrofilarija(Dirofilaria repens),
• the treatment of circulating microfilariae (Dirofilaria immitis), 
• suzbijanje cirkulirajućih mikrofilarija(Dirofilaria immitis),
Only “Advocate for small cats and ferrets” (0.4 ml) must be used. 
Smije se primjenjivati samo Advocate za male mačke i afričke tvorove (0,4 ml).
Prevention of heartworm disease (D. immitis) and cutaneous dirofilariosis (skin worm) (D. repens) 
Sprječavanje srčane dirofilariloze (D. immitis) i potkožne dirofilarioze (potkožni crv) (D. repens)
• the treatment of the lungworm Eucoleus aerophilus (syn. 
• liječenje invazije plućnim crvom Eucoleus aerophilus (syn.
• the prevention of angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum), 
• sprečavanje angiostrongiloze (L4 ličinke i nedozreli odrasli i odrasli stadiji Angiostrongylus vasorum),
Clear yellow to brownish solution. 
Bistra žuta do smeđa otopina.
Prevention of Aelurostrongylus abstrusus 
Prevencija invazije s Aeluostrongylus abstrusus
Manufacturer responsible for batch release: KVP Pharma + Veterinär Produkte GmbH Projensdorfer Str. 324, 24106 Kiel 
KVP Pharma + Veterinär Produkte GmbH Projensdorfer Str. 324, 24106 Kiel
The treatment of cats weighing less than 1 kg and ferrets weighing less than 0.8 kg should be based on a benefit-risk assessment. 
Tretiranje mačaka lakših od 1 kg i afričkih tvorova lakših od 0,8 kg treba temeljiti na procjeni koristi rizika.
Existing pupae in the environment may emerge for 6 weeks or longer after treatment is initiated, depending upon climatic conditions. 
Ovisno o klimatskim uvjetima, iz postojećih kukuljica u okolišu mogu izaći odrasle buhe 6 ili više tjedana nakon početnog tretmana.
The product should be administered monthly. 
Proizvod se primjenjuje u jednom mjesečno.
Benzyl alcohol Butylhydroxytoluene 1 mg/ml (E 321; as antioxidant). 
Benzilni alkohol Butilhidroksi-toluen 1 mg/ml (E-321; kao antioksidans).
Up to 10 times the recommended dose was tolerated in adult dogs with no evidence of adverse effects or undesirable clinical signs. 
Do 10 puta veće doze od preporučenih tolerirane su kod odraslih pasa bez vidljivih nuspojava ili nepovoljnih kliničkih simptoma.
• the prevention of spirocercosis (Spirocerca lupi), 
• Sprečavanje spirocerkoze (Spirocerca lupi),
Treatment of notoedric mange (Notoedres cati) 
Suzbijanje notoedres šuge (Notoedres cati)
Dogs should not be allowed to swim in surface waters for 4 days after treatment. 
Psima treba onemogućiti da se kupaju u otvorenim vodama
Treatment of cutaneous dirofilariosis (skin worm) (adult stages of Dirofilaria repens) 
Liječenje potkožne dirofilarioze (potkožni crv) (odrasli stadiji Dirofilaria repens)
• the prevention of lungworm disease (L3/L4 larvae of Aelurostrongylus abstrusus), 
• prevencija invazije plućnim crvom (L3/L4 ličinke Aelurostrongylus abstrusus)
Advocate for extra-large dogs (> 25-40 kg) 
Advocate za vrlo velike pse (> 25-40 kg)
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for cats. 
Preporučene minimalne doze su 10 mg/kg tjelesne mase imidakloprida i 1,0 mg/kg tjelesne mase moksidektina, što iznosi 0,1 ml/kg tjelesne mase Advocate za mačke.
• the treatment of notoedric mange (Notoedres cati), 
• liječenje šuge (Notoedres cati),
Care should be taken that the contents of the pipette do not come into contact with the eyes or mouth of the recipient and/or other animals. 
Potreban je oprez da sadržaji pipete ili aplicirane doze ne dođe u doticaj s očima ili ustima tretirane i/ili druge životinje.
Container material 
Materijal ambalaže
• the treatment of biting lice (Trichodectes canis), 
• suzbijanje pauši (Trichodectes canis),
Please refer to section 4.5. 
Pogledajte odjeljak 4.5.
Blister pack containing 1, 2, 3, 4, 6, 9, 12, 21 or 42 unit dose pipettes. 
Blister pakiranje sadržava 1, 2, 3, 4, 6, 9, 12, 21 ili 42 pojedinačne pipete.
One treatment prevents further flea infestation for 4 weeks. 
Jednokratnim tretmanom sprječava se nova infestacija buhama sljedeća 4 tjedna.
• the treatment of the eye worm Thelazia callipaeda (adults), 
• suzbijanje očnog crva Thelazia callipaeda (odrasli stadiji),
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 2.5 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for dogs. 
Preporučene minimalne doze su 10 mg/kg tjelesne mase imidakloprida i 2,5 mg/kg tjelesne mase moksidektina, što iznosi 0,1 ml/kg tjelesne mase Advocate za pse.
• the treatment of cutaneous dirofilariosis (adult stages of Dirofilaria repens) 
• liječenje potkožne dirofilarioze (odrasli stadiji Dirofilaria repens)
In endemic areas regular monthly applications will prevent angiostrongylosis and patent infection with Angiostrongylus vasorum. 
U enzootskim područjima redovito mjesečno spriječiti će angiostrongilozu i patentnu invaziju s
Moxidectin interacts with GABA and glutamate-gated chloride channels. 
Moksidektin posreduje kod gama-aminomaslačne kiseline i glutamata koji posreduju otvaranju-zatvaranju kloridnih kanala.
Each 2.5 ml pipette contains: Active substances: 250 mg imidacloprid, 62.5 mg moxidectin. 
Svaka pipeta od 2,5 ml sadržava: Djelatne tvari: 250 mg imidakloprid, 62,5 mg moksidektin.
• the treatment of the lungworm Aelurostrongylus abstrusus (adults), 
• liječenje invazije plućnim crvom Aelurostrongylus abstrusus (odrasli stadiji)
Up to 10 times the recommended dose was tolerated in cats with no evidence of adverse effects or undesirable clinical signs. 
Mačke podnose do deseterostruko veću dozu od preporučene bez dokaza nepovoljnih učinaka ili nepoželjnih kliničkih simptoma.
For medium dogs weighing between 4 kg and 10 kg. 
Za srednje velike pse od 4 do 10 kg.
Roundworm and hookworm treatment (Toxocara cati and Ancylostoma tubaeforme) 
Suzbijanje askarida i ankilostomida (Toxocara cati i Ancylostoma tubaeforme)
For dogs of more than 25 kg: 
Za pse teže od 25 kg:
Pack sizes: 0.4 ml and 0.8 ml per pipette; blister packs containing 1, 2, 3, 4, 6, 9, 12, 21 or 42 unit dose pipettes. 
Veličina pakiranja: 0,4 i 0,8 ml pipete: blister pakiranja sadržavaju 1, 2, 3, 4, 6, 9, 12, 21 i 42 pipete.
A single dose of the product should be administered. 
Proizvod se jednokratno aplicira.
4.9 Amounts to be administered and administration route Dosage schedule: 
4.9 Količine koje se primjenjuju i put primjene Tablica doziranja za mačke:
Roundworm, hookworm and whipworm treatment (Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina and Trichuris vulpis). 
Suzbijanje askarida, ankilostomida i bičastih crva (Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonine i Trichuris vulpis).
Each 0.8 ml pipette contains: Active substances: 80 mg imidacloprid, 8 mg moxidectin 
Svaka pipeta od 0,8 ml sadržava: Djelatne tvari: 80 mg imidakloprid, 8 mg moksidektin
Treatment of biting lice (Trichodectes canis) 
Suzbijanje pauši (Trichodectes canis)
Advocate for small cats and ferrets (≤ 4 kg) 
Advocate za male mačke i afričke tvorove (≤ 4 kg)
For small cats weighing 4 kg or less and ferrets 
Za male mačke teške do 4 kile i afričke tvorove
NAME OF THE MARKETING AUTHORISATION HOLDER 
NAZIV NOSITELJA ODOBRENJA
Advocate for dogs contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin. 
Advocate spot-on za pse sadržava 100 mg/ml imidakloprida i 25 mg/ml moksidektina.
The product was administered to puppies at up to 5 times the recommended dose, every 2 weeks for 6 treatments, and there were no serious safety concerns. 
Proizvod je primijenjen kod štenaca u dozi pet puta većoj od preporučene 6 puta svaka dva tjedna, bez ozbiljnih učinaka glede sigurnosti.
Advocate for large dogs (> 10-25 kg) 
Advocate za velike pse ( >10-25 kg)
If the animal licks the application site after treatment, neurological signs (most of which are transient) such as ataxia, generalised tremors, ocular signs (dilated pupils, little pupillary reflex, nystagmus), abnormal respiration, salivation and vomiting may be observed in very rare cases. 
Ako životinja nakon nakapavanja liže mjesto aplikacije, mogu se u vrlo rijetkim slučajevima uočiti neurološki simptomi (od kojih je većina prolazna) kao što je ataksija, generalizirani tremori, očni simptomi (proširene zjenice, slab pupilarni refleks, nistagmus), abnormalno disanje, slinjenje i povraćanje
Advocate 250 mg + 62.5 mg spot-on solution for large dogs Imidacloprid, moxidectin 
Advocate 250 mg + 62,5 mg spot-on otopina za velike pse Imidakloprid, moksidektin
Advocate should be administered monthly for six consecutive months. 
Advocate bi trebalo primijeniti jednom mjesečno tijekom šest mjeseci.
Advocate for cats contains 100 mg/ml imidacloprid and 10 mg/ml moxidectin. 
Advocate za mačke sadržava 100 mg/ml imidakloprida i 10 mg/ml moksidektina.
For cats suffering from, or at risk from, mixed parasitic infections: 
Za mačke koje boluju od mješovitih parazitarnih invazija ili su u opasnosti od invazije:
The product was administered to ferrets at 5 times the recommended dose, every 2 weeks for 4 treatments, and there was no evidence of adverse effects or undesirable clinical signs. 
Proizvod je primijenjen afričkim tvorovima u dozi 5 puta većoj od preporučene, 4 puta s razmacima od 2 tjedna, i nije bilo vidljivih štetnih kliničkih učinaka.
In areas endemic for heartworm, monthly treatment may significantly reduce the risk of re-infection caused by the respective roundworms and hookworms. 
U enzootskim područjima dirofilarioze mjesečnim tretmanom može se znatno umanjiti opasnost od reinvazije mačaka askaridima i ankilostomidima.
Advocate for medium dogs (> 4-10 kg) 
Advocate za srednje velike pse (> 4-10 kg)
For extra-large dogs weighing between 25 kg and 40 kg. 
Za vrlo velike pse od 25 do 40 kg.