natgillin/translations-raw huggingface dataset:
The most common adverse reactions were headache, nasopharyngitis, back pain, and arthralgia, which were common, by MedDRA definition, in both the Circadin and placebo treated groups. 
Najčešće nuspojave bile su glavobolja, nazofaringitis, bol u leđima i artralgija, koje su prema MedDRA definiciji bile česte, kako u skupini koja je uzimala Circadin, tako i u skupini koja je uzimala placebo.
If you forget to take Circadin 
Ako ste zaboravili uzeti Circadin
No studies on the use of Circadin in people with auto-immune diseases have been performed; therefore, you should speak to your doctor before taking Circadin as its use is not recommended. 
Nisu provedena ispitivanja o primjeni Circadina u osoba s autoimunim bolestima, stoga biste trebali razgovarati sa svojim liječnikom prije uzimanja Circadina jer njegova upotreba nije preporučena.
Therefore, interactions between melatonin and other active substances as a consequence of their effect on CYP1A enzymes is possible. 
Stoga su moguće interakcije između melatonina i drugih djelatnih tvari zbog posljedica njihova učinka na enzime CYP1A.
Circadin contains lactose. 
Circadin sadrži laktozu.
The levels assessed in the blood of the patients at 23:00 (2 hours after administration) following 1 and 3 weeks of daily administration were 411.4 ± 56.5 and 432.00 ± 83.2 pg/ml respectively, and are similar to those found in in healthy volunteers following a single dose of Circadin 2 mg. 
Koncentracija u krvi bolesnika u 23:00 sata (2 sata nakon primjene) iznosila je 411,4 ± 56,5 pg/ml nakon jednog tjedna odnosno 432,00 ± 83,2 pg/ml nakon 3 tjedna svakodnevne primjene te je bila slična onima pronađenim kod zdravih dobrovoljaca nakon jedne doze Circadina od 2 mg.
• Caution should be exercised in patients on 5- or 8-methoxypsoralen (5 and 8-MOP), which increases melatonin levels by inhibiting its metabolism. 
• Potreban je oprez u bolesnika koji uzimaju 5- ili 8-metoksipsoralen (5- i 8-MOP), koji povećava razinu melatonina tako što inhibira njegov metabolizam.
Circadin may cause drowsiness, therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety. 
Circadin može uzrokovati pospanost, stoga se lijek mora koristiti s oprezom u slučaju kada bi učinci pospanosti mogli ugroziti sigurnost osobe.
Plasma melatonin levels in patients with cirrhosis were significantly increased during daylight hours. 
Razine melatonina u plazmi u bolesnika s cirozom jetre bile su značajno povišene tijekom dana.
Vertigo positional, vertigo 
Poremećaji uha i labirinta pozicijski vertigo, vertigo
Circadin shortened patients' reported sleep latency by 24.3 minutes vs 12.9 minutes with placebo. 
Circadin je skratio vrijeme do usnivanja, prema navodima ispitanika, za 24,3 minute u odnosu na 12,9 minuta u ispitanika koji su primali placebo.
Quality of life was improved significantly with Circadin 2 mg compared to placebo. 
Kvaliteta života značajno se poboljšala u ispitanika koji su primali Circadin u dozi od 2 mg u usporedbi s onima koji su uzimali placebo.
Therefore, breast-feeding is not recommended in women under treatment with melatonin. 
Stoga se ne preporučuje dojenje ženama koje se liječe melatoninom.
The effect of any stage of renal impairment on melatonin pharmacokinetics has not been studied. 
Nije ispitan učinak bilo kojeg stupnja oštećenja bubrega na farmakokinetiku melatonina.
Across a range of doses, higher AUC and Cmax levels have been reported in older patients compared to younger patients, reflecting the lower metabolism of melatonin in the elderly. 
Pri primjeni različitih doza, stariji bolesnici imali su veće vrijednosti AUC i Cmax nego mlađi bolesnici, što ukazuje na slabiji metabolizam melatonina u starijih osoba.
• CYP1A2 inducers such as carbamazepine and rifampicin may give rise to reduced plasma concentrations of melatonin. 
• Induktori CYP1A2, kao što su karbamazepin i rifampicin, mogu prouzročiti sniženje koncentracije melatonina u plazmi.
Therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety. 
Stoga se lijek mora koristiti s oprezom u slučaju kada bi učinci pospanosti mogli ugroziti sigurnost osobe.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. 
Ako Vam je liječnik rekao da ne podnosite neke šećere, potražite savjet svog liječnika prije uzimanja ovog lijeka.
Melatonin is a naturally occurring hormone produced by the pineal gland and is structurally related to serotonin. 
Melatonin je hormon koji se prirodno proizvodi u hipofizi i strukturom je sličan serotoninu.
Circadin is used on its own for the short-term treatment of primary insomnia (persistent difficulty in getting to sleep or staying asleep, or poor quality of sleep) in patients aged 55 years and older. 
Circadin se koristi kao samostalna terapija za kratkoročno liječenje primarne nesanice (ustrajne poteškoće s usnivanjem ili održavanjem sna ili slaba kvaliteta sna), u bolesnika u dobi od 55 ili više godina.
• Melatonin's metabolism is mainly mediated by CYP1A enzymes. 
• Metabolizam melatonina uglavnom se odvija putem enzima CYP1A.
Nervous system disorders were more common in the active group with 42% patients, compared to 23% in the placebo group, mainly driven by somnolence and headache more frequent in the active group. 
Poremećaji živčanog sustava bili su češći u skupini koja je primala aktivno liječenje i pojavili su se u 42 % bolesnika, u usporedbi s 23 % bolesnika u skupini koja je primala placebo, te su uglavnom bili izazvani somnolencijom i glavoboljom koje su se pojavljivale češće u skupini koja je primala aktivno liječenje.
• Caution should be exercised in patients on fluvoxamine, which increases melatonin levels (by 17-fold higher AUC and a 12-fold higher serum Cmax) by inhibiting its metabolism by hepatic cytochrome P450 (CYP) isozymes CYP1A2 and CYP2C19. 
• Potreban je oprez u bolesnika koji uzimaju fluvoksamin, koji povećava razinu melatonina (17 puta veća AUC i 12 puta veća serumska Cmax) tako što inhibira njegov metabolizam putem izoenzima CYP1A2 i CYP2C19 jetrenog citokroma P450 (CYP).
The rate of melatonin absorption and Cmax following Circadin 2 mg oral administration is affected by food. 
Brzina apsorpcije melatonina i Cmax nakon peroralne primjene Circadina u dozi od 2 mg mijenja se pod utjecajem hrane.
Uncommon: (may affect up to 1 in 100 people) 
Manje često: (može se javiti kod do 1 na 100 osoba)
Excipient with known effect: each prolonged-release tablet contains 80 mg lactose monohydrate. 
Pomoćna tvar s poznatim učinkom: jedna tableta s produljenim oslobađanjem sadrži 80 mg laktoze hidrata.
Crushing or chewing should not be used to facilitate swallowing. 
Gutanje se ne smije olakšavati drobljenjem ili žvakanjem.
• CYP1A2 inhibitors such as quinolones may give rise to increased melatonin exposure. 
• Inhibitori CYP1A2, poput kinolona, mogu dovesti do povećane ekspozicije melatoninu.
Only those adverse reactions reported during clinical trials occurring in patients at an equivalent or greater rate than placebo have been included below. 
U dolje navedenoj tablici prikazane su samo nuspojave prijavljene tijekom kliničkih ispitivanja koje su se u bolesnika javile u jednakoj ili većoj stopi od one uz placebo.
Blood and lymphatic system disorders 
Poremećaji krvi i limfnog sustava leukopenija,
No clinical data exist concerning the use of Circadin in individuals with autoimmune diseases. 
Nema kliničkih podataka o primjeni Circadina u osoba s autoimunim bolestima.
No studies on the use of Circadin in people with liver or kidney diseases have been performed, you should speak to your doctor before taking Circadin as its use is not recommended. 
Nisu provedena ispitivanja o primjeni Circadina u osoba s bolestima jetre ili bubrega, trebali biste razgovarati sa svojim liječnikom prije uzimanja Circadina jer njegova primjena nije preporučena.
Endogenous melatonin was measured in human breast milk thus exogenous melatonin is probably secreted into human milk. 
Endogeni melatonin je ustanovljen u majčinom mlijeku u ljudi, pa se u majčino mlijeko vjerojatno izlučuje i egzogeni melatonin.
Hypertriglyceridaemia, hypocalcaemia, hyponatraemia 
Hipertrigliceridemija, hipokalcemija,
In clinical trials (in which a total of 1,931 patients were taking Circadin and 1,642 patients were taking placebo), 48.8% of patients receiving Circadin reported an adverse reaction compared with 37.8% taking placebo. 
U kliničkim je ispitivanjima (u kojima je ukupno 1931 bolesnik uzimao Circadin, dok su 1642 uzimala placebo) nuspojavu prijavilo 48,8% bolesnika koji su primali Circadin i 37,8% onih koji su uzimali placebo.
Somnolence was the most reported adverse event. 
Najčešće prijavljena nuspojava bila je somnolencija.
Several cases of overdose have been reported post-marketing. 
Nakon što je lijek stavljen u promet, prijavljeno je nekoliko slučaja predoziranja.
Clearance of the active substance is expected within 12 hours after ingestion. 
Klirens djelatne tvari očekuje se unutar 12 sati nakon uzimanja.
A Paediatric study (n=125) with doses of 2, 5 or 10 mg prolonged-release melatonin in multiples of 1 mg minitablets (age-appropriate pharmaceutical form), with two week run in baseline period on placebo and a randomised, double blind, placebo controlled, parallel group treatment period of 13 weeks, demonstrated an improvement in total sleep time (TST) after 13 weeks of double-blind treatment; participants slept more with active treatment (508 minutes), compared to placebo 
Pedijatrijsko ispitivanje (n=125) s dozama od 2, 5 ili 10 mg melatonina s produljenim oslobađanjem u višestrukim mini tabletama od 1 mg (farmaceutski oblik primjeren dobnoj skupini), koje se sastojalo od dva tjedna uvodnog liječenja placebom i 13 tjedana randomiziranog, dvostruko slijepog, placebom kontroliranog ispitivanja na usporednim skupinama, pokazalo je poboljšanje u ukupnom vremenu spavanja nakon 13 tjedana dvostruko slijepog liječenja; sudionici koji su primali aktivno liječenje spavali su dulje (508 minuta) od sudionika koji su primali placebo (488 minuta).
INFORMATION IN BRAILLE Circadin 2 mg 
Circadin 2 mg
The presence of food delayed the absorption of the melatonin resulting in a later (Tmax=3.0 h versus Tmax=0.75 h) and lower peak plasma concentration in the fed state (Cmax=1020pg/ml versus Cmax=1176 pg/ml). 
Prisutnost hrane odgađa apsorpciju melatonina, pa vršna koncentracija melatonina u plazmi u stanju sitosti nastupa kasnije (Tmax = 3,0 h prema Tmax = 0,75 h) i ima nižu vrijednost (Cmax = 1020 pg/ml prema Cmax = 1176 pg/ml).
Each carton of tablets contains one blister strip of 7, 20 or 21 tablets, or alternatively in a carton containing two blister strips of 15 tablets each (30 tablet pack). 
Jedna kutija tableta sadrži jedan blister s 7, 20 ili 21 tabletom ili se u kutiji nalaze dva blistera koji svaki sadrži 15 tableta (30 tableta).
Angina pectoris, palpitations 
Srčani poremećaji angina pektoris,
The liver is the primary site of melatonin metabolism and therefore, hepatic impairment results in higher endogenous melatonin levels. 
Budući da je jetra primarno mjesto metabolizma melatonina, oštećenje jetre dovodi do povećanja razine endogenog melatonina.
However, no pharmacodynamic differences between males and females were found despite differences in blood levels. 
Međutim, usprkos razlikama u koncentraciji u krvi, farmakodinamičke razlike između muškaraca i žena nisu pronađene.
• Caution should be exercised in patients on oestrogens (e.g. contraceptive or hormone replacement therapy), which increase melatonin levels by inhibiting its metabolism by CYP1A1 and CYP1A2. 
• Potreban je oprez u bolesnica koje uzimaju estrogene (npr. kontracepcijske tablete ili hormonsku nadomjesnu terapiju) jer estrogeni povisuju razinu melatonina tako što inhibiraju njegovo metaboliziranje putem CYP1A1 i CYP1A2.
Administration of daily doses of up to 300 mg of melatonin without causing clinically significant adverse reactions have been reported in the literature. 
U literaturi je navedena primjena dnevnih doza melatonina do najviše 300 mg koja nije prouzročila klinički značajne nuspojave.
• Caution should be exercised in patients on cimetidine a CYP2D inhibitor, which increases plasma melatonin levels, by inhibiting its metabolism. 
• Potreban je oprez u bolesnika koji uzimaju cimetidin, inhibitor CYP2D, koji povećava razine melatonina u plazmi tako što inhibira njegov metabolizam.
Therefore, interactions between melatonin and other active substances as a consequence of melatonin's effect on CYP1A enzymes are not likely to be significant. 
Stoga vjerojatno neće biti značajnih interakcija između melatonina i drugih djelatnih tvari zbog učinka melatonina na enzime CYP1A.
Syncope, memory impairment, disturbance in attention, dreamy state, restless legs syndrome, poor quality sleep, paraesthesia 
somnolencija sinkopa, narušeno pamćenje, poremećaj pozornosti, sanjivo stanje, sindrom nemirnih nogu, loša kvaliteta sna,
In clinical trials, where patients suffering from primary insomnia received Circadin 2 mg every evening for 3 weeks, benefits were shown in treated patients compared to placebo in sleep latency (as measured by objective and subjective means) and in subjective quality of sleep and daytime functioning (restorative sleep) with no impairment of vigilance during the day. 
U kliničkim ispitivanjima u kojima su bolesnici s primarnom nesanicom primali Circadin u dozi od 2 mg svake večeri tijekom 3 tjedna, Circadin je u liječenih bolesnika, u usporedbi s onima koji su primali placebo, imao korisne učinke u smislu vremena do usnivanja (mjereno objektivnim i subjektivnim metodama), subjektivne kvalitete sna te dnevnog funkcioniranja (okrepljujući san) bez smanjene budnosti tijekom dana.
The excretion of the metabolite is completed within 12 hours after ingestion. 
Metaboliti se potpuno izluče unutar 12 sati nakon peroralne primjene.
RAD Neurim Pharmaceuticals EEC SARL 4 rue de Marivaux 
NOSITELJ ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET RAD Neurim Pharmaceuticals EEC SARL 4 rue de Marivaux
- The other ingredients are ammonio methacrylate copolymer type B, calcium hydrogen phosphate dihydrate, lactose monohydrate, silica (colloidal anhydrous), talc and magnesium stearate. 
- Drugi sastojci su amonio-metakrilat kopolimer vrste B, kalcijev hidrogenfosfat dihidrat, laktoza hidrat, silicijev dioksid, koloidni, bezvodni, talk, magnezijev stearat.
How to take Circadin 
Kako uzimati Circadin
Visual acuity reduced, vision blurred, lacrimation increased 
Poremećaji oka smanjena oštrina vida, zamagljen vid, pojačano suzenje
There was also a reduction in sleep latency with active treatment (61 minutes) compared to placebo (77 minutes) after 13 weeks of double-blind treatment, without causing earlier wake-up time. 
Nakon 13 tjedana dvostruko slijepog liječenja kod primjene aktivnog liječenja došlo je i do skraćenja vremena latencije sna u sudionika (61 minuta) u usporedbi s primjenom placeba (77 minuta), bez uzrokovanja ranijeg vremena buđenja.
QUALITATIVE AND QUANTITATIVE COMPOSITION Each prolonged-release tablet contains 2 mg melatonin. 
KVALITATIVNI I KVANTITATIVNI SASTAV Jedna tableta s produljenim oslobađanjem sadrži 2 mg melatonina.
Published data demonstrates markedly elevated endogenous melatonin levels during daytime hours due to decreased clearance in patients with hepatic impairment. 
Objavljeni podaci pokazuju da su u bolesnika s oštećenjem jetre razine endogenog melatonina značajno povišene tijekom dnevnih sati zbog smanjenog klirensa.
If you suffer from continued drowsiness, then you should consult your doctor. 
Ako ste stalno pospani, potražite savjet liječnika.
What Circadin looks like and contents of the pack Circadin 2 mg prolonged-release tablets are available as white to off-white round bi-convex shaped tablets. 
Circadin 2 mg tablete s produljenim oslobađanjem dostupne su kao bijele do gotovo bijele okrugle bikonveksne tablete.
Herpes zoster 
Infekcije i infestacije herpes zoster
Tfno: +34 91 7711500 
EXELTIS HEALTHCARE, S.L. Tfno: +34 91 7711500
If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 
U slučaju bilo kakvih pitanja u vezi s primjenom ovog lijeka, obratite se svojem liječniku ili ljekarniku.
At 3 months, about an extra 10% of responders were seen in the Circadin treated group. 
Nakon 3 mjeseca u skupini liječenih Circadinom bilo je 10% više bolesnika koji su odgovorili na liječenje.
For melatonin, no clinical data on exposed pregnancies are available. 
Nema dostupnih kliničkih podataka o utjecaju melatonina na trudnoću.
Therefore, Circadin is not recommended for use in patients with autoimmune diseases. 
Stoga se ne preporučuje primjena Circadina u bolesnika s autoimunim bolestima.
Circadin contains lactose monohydrate. 
Circadin sadrži laktozu hidrat.
Shingles, high level of fatty molecules in the blood, low serum calcium levels in the blood, low sodium levels in the blood, altered mood, aggression, agitation, crying, stress symptoms, early morning awakening, increased sex drive, depressed mood, memory impairment, disturbance in attention, dreamy state, restless legs syndrome, poor quality sleep, ‘pins and needles' feeling, watery eyes, dizziness when standing or sitting, hot flushes, acid reflux, stomach disorder, blistering in the mouth, tongue ulceration, stomach upset, vomiting, abnormal bowel sounds, wind, excess saliva production, bad breath, abdominal discomfort, gastric disorder, inflammation of the stomach lining, eczema, skin rash, hand dermatitis, itchy rash, nail disorder, arthritis, muscle spasms, neck pain, night cramps, prolonged erection that might be painful, inflammation of the prostate gland, tiredness, pain, thirst, passing large volumes of urine, urinating during the night, increased liver enzymes, abnormal blood electrolytes and abnormal laboratory tests. 
herpes zoster, povišena razina masnoća u krvi, smanjena razina kalcija u serumu, smanjena razina natrija u krvi, promjena raspoloženja, agresivnost, uznemirenost, plačljivost, simptomi stresa, ranojutarnje buđenje, pojačani spolni nagon, loše raspoloženje, oslabljeno pamćenje, poremećaj pozornosti, stanje sanjivosti, sindrom nemirnih nogu, slaba kakvoća sna, trnci, suzenje očiju, omaglica pri stajanju ili sjedenju, navale vrućine, vraćanje želučane kiseline, poremećaji u trbuhu, mjehurići na sluznici usta, ulceracije (oštećenja) na jeziku, probavne tegobe, povraćanje, glasan rad crijeva, vjetrovi, pretjerano stvaranje sline, neugodan zadah iz usta, nelagoda u trbuhu, želučani poremećaji, upala sluznice želuca, ekcem, kožni osip, dermatitis na rukama, osip sa svrbežom, promjene na noktima, artritis, grčevi mišića, bol u vratu, noćni grčevi, produljeno trajanje erekcije koje može biti bolno, upala prostate, umor, bol, žeđanje, pojačano izlučivanje mokraće, mokrenje tijekom noći, povišenje jetrenih enzima, poremećeni elektroliti u krvi i poremećeni rezultati laboratorijskih testova.
In addition, quality of sleep and morning alertness significantly improved with Circadin compared to placebo. 
Uz to su kakvoća sna i jutarnja budnost bile značajno bolje u skupini koja je primala Circadin u usporedbi sa skupinom koja je primala placebo.
Irritability, nervousness, restlessness, insomnia, abnormal dreams, nightmares, anxiety, migraine, headache, lethargy (tiredness, lack of energy), restlessness associated with increased activity, dizziness, tiredness, high blood pressure, upper abdominal pain, indigestion, mouth ulceration, dry mouth, nausea, changes in the composition of your blood which could cause yellowing of the skin or eyes, inflammation of the skin, night sweats, itching, rash, dry skin, pain in extremities, menopausal symptoms, feeling of weakness, excretion of glucose in the urine, excess proteins in the urine, abnormal liver function and weight increase. 
razdražljivost, nervoza, nemir, nesanica, neuobičajeni snovi, noćne more, tjeskoba, migrena, glavobolja, letargija (umor, nedostatak energije), nemir povezan s pojačanom aktivnošću, omaglica, umor, povišeni krvni tlak, bol u gornjem trbuhu, loša probava, ulceracije (oštećenja) sluznice usta, suha usta, mučnina, promjene u sastavu krvi koje mogu prouzročiti žutilo kože ili očiju, upala kože, noćno znojenje, svrbež, osip, suhoća kože, bol u udovima, simptomi menopauze, osjećaj slabosti, izlučivanje glukoze u urinu, povišena razina proteina u urinu, poremećena funkcija jetre i povećanje tjelesne težine.
How to store Circadin 
Kako čuvati Circadin
Polyuria, haematuria, nocturia 
proteinurija poliurija, hematurija, nokturija
Patients had a significantly decreased total excretion of 6-sulfatoxymelatonin compared with controls. 
Ukupno izlučivanje 6-sulfatoksimelatonina bilo je značajno manje u bolesnika s cirozom nego u kontrolnih ispitanika.
Caution should be used when melatonin is administered to such patients. 
Melatonin se u ovih bolesnika mora primjenjivati s oprezom.
There is no experience of the use of Circadin in patients with liver impairment. 
Nema iskustva s primjenom Circadina u bolesnika s oštećenjem jetre.
Ammonio methacrylate copolymer type B Calcium hydrogen phosphate dihydrate Lactose monohydrate Silica, colloidal anhydrous Talc 
6.1 Popis pomoćnih tvari amonio-metakrilat kopolimer vrste B kalcijev hidrogenfosfat dihidrat laktoza hidrat silicijev dioksid, koloidni, bezvodni talk magnezijev stearat
In a polysomnographic (PSG) study with a run-in of 2 weeks (single-blind with placebo treatment), followed by a treatment period of 3 weeks (double-blind, placebo-controlled, parallel group design) and a 3-week withdrawal period, sleep latency (SL) was shortened by 9 minutes compared to placebo. 
U polisomnografskom (PSG) ispitivanju uz uvodno liječenje u trajanju od 2 tjedna (jednostruko slijepo s placebom), nakon kojeg je uslijedilo razdoblje liječenja od 3 tjedna (dvostruko slijepo, placebom kontrolirano ispitivanje na usporednim skupinama) te 3-tjedno razdoblje ustezanja, vrijeme do nastupa sna bilo je skraćeno za 9 minuta u usporedbi s placebom.
Each prolonged-release tablet contains 2 mg melatonin. 
Jedna tableta s produljenim oslobađanjem sadrži 2 mg melatonina.
Package Leaflet: Information for the patient Circadin 2 mg prolonged-release tablets Melatonin 
Uputa o lijeku: Informacije za bolesnika Circadin 2 mg tablete s produljenim oslobađanjem melatonin
• Melatonin has been observed to induce CYP3A in vitro at supra-therapeutic concentrations. 
• Primijećeno je da melatonin u koncentracijama višim od terapijskih inducira CYP3A in vitro.
• Severe chest pain due to angina 
• jaka bol u grudima uzrokovana anginom
PHARMACEUTICAL FORM Prolonged-release tablet. 
OBLIK Tableta s produljenim oslobađanjem.
NAME OF THE MEDICINAL PRODUCT Circadin 2 mg prolonged-release tablets 
NAZIV LIJEKA Circadin 2 mg tablete s produljenim oslobađanjem
In a second outpatient study with two week run in baseline period with placebo and a randomised, double blind, placebo controlled, parallel group treatment period of 3 weeks, the rate of patients who showed a clinically significant improvement in both quality of sleep and morning alertness was 26% in the Circadin group as compared to 15% in the placebo group. 
U drugom ispitivanju u ambulantnih bolesnika, koje se sastojalo od 2 tjedna uvodnog liječenja placebom i 3 tjedna randomiziranog, dvostruko slijepog, placebom kontroliranog ispitivanja na usporednim skupinama, postotak bolesnika koji su pokazali klinički značajno poboljšanje u kvaliteti sna i jutarnjoj budnosti iznosio je 26% u skupini koja je primala Circadin, u usporedbi s 15% u skupini koja je primala placebo.
• Visual impairment 
• oštećenje vida • zamagljen vid
STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 2 mg melatonin. 
NAVOĐENJE DJELATNE(IH) TVARI Jedna tableta sadrži 2 mg melatonina.
• Presence of red blood cells in the urine 
• pojava eritrocita u urinu