natgillin/translations-raw huggingface dataset:
Glycerol phenylbutyrate is not recommended during pregnancy and in women of childbearing potential not using contraception. 
Ne preporučuje se koristiti lijek glicerolfenilbutirat tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste kontracepciju.
Adverse reactions reported in more paediatric than adult patients during long-term treatment with glycerol phenylbutyrate included upper abdominal pain (3 of 49 paediatric [6.1%] versus 1 of 51 adults [2.0%] and increased anion gap (2 of 49 paediatric [4.1%] versus 0 of 51 adults [0%]. 
Nuspojave prijavljene kod više pedijatrijskih nego odraslih bolesnika tijekom dugotrajnog liječenja glicerolfenilbutiratom uključivale su bol u gornjem dijelu abdomena (3 od 49 pedijatrijskih [6,1%] naspram 1 od 51 odraslih bolesnika [2,0%]) i povećani anionski jaz (2 od 49 pedijatrijskih bolesnika [4,1%] naspram 0 od 51 odraslih [0%]).
Increased aspartate aminotransferase, alanine aminotransferase increased, increased anion gap, decreased lymphocyte count, decreased vitamin D Uncommon Blood potassium increased, blood triglycerides increased, electrocardiogram abnormal, low density lipoprotein increased, prothrombin time prolonged, white blood cell count increased, weight increased, weight decreased 
Povišene vrijednosti aspartat aminotransferaze, povišene vrijednosti alanin aminotranferaze, povećani anionski jaz (engl. anion gap), smanjen broj limfocita, smanjena razina vitamina D Manje često Povišen kalij u krvi, povišeni trigliceridi u krvi, abnormalni elektrokardiogram, povišen lipoprotein niske gustoće, produljeno protrombinsko vrijeme, povišen broj leukocita, povećanje tjelesne težine, smanjenje tjelesne težine
Do not add and stir the medicinal product into a large volume of other liquid, as glycerol phenylbutyrate is heavier than water and this may result in incomplete administration. 
Nemojte dodavati niti miješati lijek u velikom volumenu druge tekućine jer je glicerolfenilbutirat teži od vode što može uzrokovati nepotpunu primjenu.
It is unknown whether glycerol phenylbutyrate or its metabolites are excreted in human milk. 
Nije poznato izlučuju li se glicerolfenilbutirat ili njegovi metaboliti u majčino mlijeko.
Glycerol phenylbutyrate has been tested in a range of in vitro and in vivo genotoxicity studies, and shown no genotoxic activity. 
Glicerolfenilbutirat ispitivan je u rasponu in vitro i in vivo ispitivanja genotoksičnosti i nije pokazao genotoksičnu aktivnost.
• less able to remember things 
• oslabljena sposobnost pamćenja
It is not recommended to administer a dose of 0.5 ml or less with nasogastric, gastrostomy or nasojejunal tubes, given the low drug recovery in dosing. 
Ne preporučuje se primijeniti dozu od 0,5 ml ili manju nazogastričnom, gastrostomom ili nazojejunalnom sondom s obzirom na mali povrat lijeka kod doziranja.
In healthy subjects, after administration of 4 ml, 6 ml, and 9 ml 3 times daily for 3 days, the ratio of mean AUC0-23h of PAA to PAGN was 1, 1.25, and 1.6, respectively. 
Kod zdravih ispitanika, nakon primjene 4 ml, 6 ml i 9 ml 3 puta dnevno tijekom 3 dana, omjer srednjeg AUC0-23h PAA i PAGN bio je 1, 1,25, odnosno 1,6.
Important note: Do not add or stir RAVICTI into larger volumes of liquid such as water or juice as the introduction of water causes glycerol phenylbutyrate to degrade. 
Važna napomena: Nemojte dodavati ni miješati RAVICTI u većim količinama tekućine poput vode ili soka, budući da dodavanje vode uzrokuje razgradnju glicerolfenilbutirata.
• Total daily dosage of RAVICTI (ml) = total daily dosage of sodium phenylbutyrate powder (g) x 0.81 
• Ukupna dnevna doza lijeka RAVICTI (ml) = ukupna dnevna doza praška natrijevog fenilbutirata (g) x 0,81
Glycerol phenylbutyrate was found to be non-inferior to sodium phenylbutyrate with respect to ammonia control in both of these paediatric studies. 
Utvrđeno je da je glicerolfenilbutirat neinferioran natrijevom fenilbutiratu s obzirom na kontrolu amonijaka u oba ta pedijatrijska ispitivanja.
Turn the bottle upside down with the oral syringe still inserted. 
Preokrenite bocu naopako dok je oralna štrcaljka još uvijek umetnuta.
Standard pack size: 1 bottle and 1 reclosable bottle cap adapter per carton. 
Standardna veličina pakiranja: 1 nastavak za bocu s čepom za ponovno zatvaranje po kutiji.
After the last dose of the day, the oral syringe should be discarded. 
Nakon zadnje doze u danu oralnu štrcaljku treba baciti.
Tap the oral syringe to remove air bubbles, making sure you have filled it with the correct amount of liquid. 
Kucnite prstima po oralnoj štrcaljki kako biste uklonili mjehuriće zraka, pazeći da ste je napunili odgovarajućom količinom tekućine.
Ammonia levels must be monitored closely when changing the dose of glycerol phenylbutyrate. 
Razine amonijaka moraju se strogo pratiti kod promjene doze glicerolfenilbutirata.
The amount of dose adjustment should factor in the amount of dietary protein that has not been covered, as indicated by the 24-h U-PAGN level and the estimated glycerol phenylbutyrate dose needed per gram of dietary protein ingested. 
Količina prilagođene doze treba biti srazmjerna količini proteina iz prehrane koja nije pokrivena, sukladno razini 24-h U-PAGN i procijenjenoj dozi glicerolfenilbutirata potrebnoj po gramu uzetih proteina iz prehrane.
• poor feeding 
• slabo uzimanje hrane.
Study in Children Less Than 2 Months of Age 
Ispitivanje u djece mlađe od 2 mjeseca
Do not re-use the oral syringe for measuring the dose of RAVICTI on another day. 
Nemojte drugi dan ponovno koristiti istu oralnu štrcaljku za odmjeravanje doze lijeka RAVICTI.
• tests show higher triglycerides, low density lipo-protein or white cells in your blood 
• nalazi pretraga pokazuju povišene trigliceride, lipoprotein niske gustoće ili bijele krvne stanice u krvi
Uncommon Gastrointestinal viral infection 
Manje često Gastrointestinalna virusna infekcija
How RAVICTI works 
Kako RAVICTI djeluje
Glycerol phenylbutyrate was non-inferior to sodium phenylbutyrate with respect to the 24-hour AUC for ammonia. 
Glicerolfenilbutirat bio je neinferioran natrijevom fenilbutiratu s obzirom na 24-satni AUC amonijaka.
Pharmacological effects 
Farmakološki učinci
Ammonia levels should be closely monitored in patients with pancreatic insufficiency or intestinal malabsorption. 
Razine amonijaka treba pomno pratiti kod bolesnika s insuficijencijom gušterače ili intestinalnom malapsorpcijom.
Package leaflet: Information for the patient RAVICTI 1.1 g/ml oral liquid 
Uputa o lijeku: Informacije za bolesnika RAVICTI 1,1 g/ml oralna tekućina glicerolfenilbutirat
Tell a doctor straight away if: • you are sick (vomit), which is a common side effect, more than once and this does not stop. 
• povraćate, što je česta nuspojava, više od jednom i to ne prestaje.
Patients had to have no clinical evidence of hyperammonaemia at enrolment and were not allowed to receive medicinal products known to increase ammonia levels (e.g., valproate), increase protein catabolism (e.g., corticosteroids), or significantly affect renal clearance (e.g., probenecid). 
Bolesnici nisu smjeli imati kliničke dokaze hiperamonemije kod uključenja i nisu smjeli primati lijekove za koje se zna da povećavaju razinu amonijaka (npr. valproat), povećavaju katabolizam proteina (npr. kortikosteroidi),
The median exposure was 10 months (range 2 to 20 months) and median exposure in the 2 months to less than 2 years of age was 9 months (range 0.2 to 20.3 months).Adverse drug reactions (ADR) are summarized below. 
Medijan izloženosti iznosio je 10 mjeseci (raspon: 2-20 mjeseci), a medijan izloženosti u dobnoj skupini od 2 mjeseca do manje od 2 godine iznosio je 9 mjeseci (raspon: 0,2-20,3 mjeseci).
Low or absent pancreatic enzymes or intestinal disease resulting in fat malabsorption may result in reduced or absent digestion of glycerol phenylbutyrate and/or absorption of phenylbutyrate and reduced control of plasma ammonia. 
Sniženje ili odsutnost enzima gušterače ili crijevna bolest koja uzrokuje malapsorpciju masti mogu rezultirati smanjenjem ili izostankom probave glicerolfenilbutirata i/ili apsorpcije fenilbutirata i smanjenom kontrolom razine amonijaka u plazmi.
Unimedic AB Storjordenvägen 2 SE-864 31 Matfors Sweden 
SE-864 31 Matfors
The incidence of the following tumours was also increased in female rats: thyroid follicular cell adenoma, carcinoma and combined adenoma or carcinoma, adrenal cortical combined adenoma or carcinoma, cervical schwannoma, uterine endometrial stromal polyp, and combined polyp or sarcoma. 
Incidencija sljedećih tumora također je bila veća kod ženki štakora: adenom folikularnih stanica štitnjače, karcinom i kombinirani adenom ili karcinom, kombinirani adenom ili karcinom nadbubrežne žlijezde, cervikalni švanom, uterini endometrijski stromalni polip i kombinirani polip ili sarkom.
No studies were conducted in UCD patients with renal impairment; the safety of glycerol phenylbutyrate in patients with renal impairment is unknown. 
Nisu provedena ispitivanja u bolesnika s poremećajima ciklusa ureje i oštećenjem bubrega; sigurnost glicerolfenilbutirata kod bolesnika s oštećenjem bubrega nije poznata.
How to take RAVICTI 
Kako uzimati RAVICTI
The mean peak ratio of PAA to PAGN in UCD patients aged birth to less than 2 months was higher (mean: 1.65; range 0.14 to 7.07) than for UCD patients aged 2 months to less than 2 years (mean 0.59; range 0.17 to 1.21). 
Srednja vrijednost omjera vršnih vrijednosti PAA i PAGN u bolesnika s poremećajima ciklusa ureje u dobi od rođenja do manje od 2 mjeseca bila je viša (srednja vrijednost: 1,65; raspon 0,14-7,07) nego u bolesnika s poremećajima ciklusa ureje u dobi od 2 mjeseca do manje od 2 godine (srednja vrijednost 0,59; raspon 0,17-1,21).
Each dose should be rounded up to the nearest 0.1 ml for patients less than 2 years of age and 0.5 ml for patients 2 years of age and older. 
Svaku dozu treba zaokružiti na najbližih 0,1 ml za bolesnike mlađe od
In vivo exposure to glycerol phenylbutyrate has resulted in decreased systemic exposure to midazolam of approximately 32% and increased exposure to the 1-hydroxy metabolite of midazolam, suggesting that steady-state dosing of glycerol phenylbutyrate results in CYP3A4 induction. 
Izloženost glicerolfenilbutiratu in vivo rezultirala je smanjenom sistemskom izloženosti midazolamu za otprilike 32% i povećanom izloženosti 1-hidroksi metabolitu midazolama, što upućuje na to da doziranje glicerolfenilbutirata u stanju dinamičke ravnoteže rezultira indukcijom enzima CYP3A4.
• feeling of pins and needles, feeling very restless, difficulty in waking up, feeling drowsy, problems with speech, feeling confused, depressed 
• osjećaj trnaca i bockanja, osjećaj jakog nemira, teško buđenje, omamljenost, problemi s govorom, smetenost, depresija
Three patients were treatment naïve and three additional patients were gradually discontinued from intravenous sodium benzoate and sodium phenylacetate while RAVICTI was initiated. 
Tri bolesnika prethodno nisu bila liječena, dok su tri dodatna bolesnika postupno prekinula primanje intravenskog natrijevog benzoata i natrijevog fenilacetata dok im se uvodio RAVICTI.
The pharmacokinetics of glycerol phenylbutyrate in patients with impaired renal function, including those with end-stage renal disease (ESRD) or those on haemodialysis, have not been studied. 
Farmakokinetika glicerolfenilbutirata kod bolesnika s oštećenjem funkcije bubrega, uključujući one sa završnim stadijem bolesti bubrega ili one na hemodijalizi, nije ispitivana.
In a study in patients with clinically decompensated cirrhosis and hepatic encephalopathy (Child-Pugh B and C), mean Cmax of PAA was 144 mcg/ml (range: 14-358 mcg /ml) after daily dosing of 6 ml of glycerol phenylbutyrate twice daily, while mean Cmax of PAA was 292 mcg /ml (range: 57-655 mcg/ml) after daily dosing of 9 ml of glycerol phenylbutyrate twice daily. 
U ispitivanju u bolesnika s klinički dekompenziranom cirozom i hepatičkom encefalopatijom (ChildPugh B i C), srednji Cmax PAA bio je 144 μg/ml (raspon: 14-358 μg /ml) nakon dnevne doze od 6 ml glicerolfenilbutirata dvaput dnevno, dok je srednji Cmax PAA bio 292 μg /ml (raspon: 57-655 μg /ml) nakon dnevne doze od 9 ml glicerolfenilbutirata dvaput dnevno.
Uncommon Ventricular arrhythmia 
Manje često Ventrikularna aritmija
• Total daily dosage of RAVICTI (ml) = total daily dosage of sodium phenylbutyrate tablets (g) x 
• Ukupna dnevna doza lijeka RAVICTI (ml) = ukupna dnevna doza tableta natrijevog fenilbutirata (g) x 0,86
In in vitro studies, the specific activity of lipases for glycerol phenylbutyrate was seen in the following decreasing order: pancreatic triglyceride lipase, carboxyl ester lipase, and pancreatic lipase-related protein 2. 
U in vitro ispitivanjima,specifična aktivnost lipaza za glicerolfenilbutirat opažena je ovim padajućim slijedom: trigliceridna lipaza gušterače, karboksil ester lipaza, i protein 2 povezan s lipazom gušterače.
An open-label, long-term study (Study 5) was conducted to assess ammonia control in paediatric patients with UCD. 
Otvoreno, dugoročno ispitivanje (Ispitivanje 5) provedeno je kako bi se ocjenila kontrola amonijaka u pedijatrijskih bolesnika s poremećajem ciklusa ureje.
• 8.5 ml/m2/day (9.4 g/m2/day) in patients with a body surface area (BSA) < 1.3 m2 
• 8,5 ml/m2/dan (9,4 g/m2/dan) za bolesnike s površinom tijela < 1,3 m2
Of the 49 paediatric patients who participated in these extension studies, 12 patients (25 %) reported a total of 17 hyperammonaemic crises during treatment with glycerol phenylbutyrate as compared with 38 crises in 21 patients (43 %) in the preceding 12 months prior to study entry, while they were being treated with sodium phenylbutyrate. 
Od 49 pedijatrijskih bolesnika koji su sudjelovali u tim produžecima ispitivanja, 12 bolesnika (25%) je prijavilo ukupno 17 hiperamonemijskih kriza tijekom liječenja glicerolfenilbutiratom u usporedbi s 38 kriza kod 21 bolesnika (43%) u 12 mjeseci prije ulaska u ispitivanje kada su bili liječeni natrijevim fenilbutiratom.
• menstrual periods stop or are irregular, hoarse voice, nosebleeds, stuffy nose, sore or painful throat, hair loss, sweating more than usual, itchy rash, uneven heartbeat, reduced thyroid function 
• prekid ili neredovitost menstruacija, promukao glas, krvarenje iz nosa, začepljen nos, nadraženo ili bolno grlo, opadanje kose, znojenje jače nego obično, osip koji svrbi, neravnomjerni otkucaji srca, smanjena funkcija štitne žlijezde
N-acetylglutamate synthase (NAGS) and CITRIN (citrullinaemia type 2) deficiency The safety and efficacy of RAVICTI for the treatment of patients with N-acetylglutamate synthase (NAGS) and CITRIN (citrullinaemia type 2) deficiency have not been established. 
Sigurnost i djelotvornost lijeka RAVICTI za liječenje bolesnika s nedostatkom N-acetilglutamat sintaze (NAGS) i CITRINA (citrulinemija tipa 2) nisu ustanovljene.
RAVICTI is indicated for use as adjunctive therapy for chronic management of patients with urea cycle disorders (UCDs) including deficiencies of carbamoyl phosphate synthetase I (CPS), ornithine carbamoyltransferase (OTC), argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL), arginase I (ARG) and ornithine translocase deficiency hyperornithinaemia-hyperammonaemia homocitrullinuria syndrome (HHH) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone. 
RAVICTI je indiciran za primjenu kao pomoćna terapija u kroničnom liječenju bolesnika s poremećajima ciklusa ureje, uključujući nedostatak karbamoil fosfat sintetaze I (CPS), ornitin karabamoil transferaze (OTC), argininosukcinat sintetaze (ASS), argininosukcinat liaze (ASL), arginaze I (ARG) i nedostatak ornitin translokaze (sindrom hiperornitinemija-hiperamonemijahomocitrulinurija, HHH) koji se ne mogu liječiti samo ograničavanjem proteina u prehrani i/ili nadomjescima aminokiselina.
The RAVICTI pack contains the medicinal product and a reclosable bottle cap adapter. 
Pakiranje lijeka RAVICTI sadrži lijek i nastavak za bocu s čepom za ponovno zatvaranje.
Of 51 adult patients participating in Study 2, 7 patients (14%) reported a total of 10 hyperammonaemic crises during treatment with glycerol phenylbutyrate as compared with 9 patients (18 %) who had reported a total of 15 crises in the 12 months prior to study entry while they were being treated with sodium phenylbutyrate. 
Od 51 odraslog bolesnika koji je sudjelovao u Ispitivanju 2,7 bolesnika (14%) je prijavilo ukupno 10 hiperamonemijskih kriza tijekom liječenja glicerolfenilbutiratom u usporedbi s 9 bolesnika (18%) koji su prijavili ukupno 15 kriza u 12 mjeseci prije ulaska u ispitivanje kada su bili liječeni natrijevim fenilbutiratom.
Swallow the liquid from the oral syringe or attach the oral syringe to a gastrostomy or nasogastric tube. 
Progutajte tekućinu iz oralne štrcaljke ili spojite oralnu štrcaljku za gastrostomu ili nazogastričnu sondu.
RAVICTI must be used with dietary protein restriction and sometimes dietary supplements (e.g., essential amino acids, arginine, citrulline, protein-free calorie supplements) depending on the daily dietary protein intake needed to promote growth and development. 
RAVICTI se mora uzimati uz ograničen unos proteina prehranom i ponekad uz dodatke prehrani (npr. esencijalne aminokiseline, arginin, citrulin, kalorijske dodatke koji ne sadrže proteine) ovisno o dnevnom unosu proteina prehranom potrebnom za poticanje rasta i razvoja.
Mean blood glutamine levels were also non-significantly lower after glycerol phenylbutyrate treatment compared with sodium phenylbutyrate treatment by -45.2 ± 142.94 micromol/L (p = 0.135, paired ttest; p = 0.114, Wilcoxon signed-rank test). 
Srednje razine glutamina u krvi također su bile ne značajno niže nakon liječenja glicerolfenilbutiratom u usporedbi s liječenjem natrijevim fenilbutiratom za -45,2 ± 142,94 mikromola/l (p = 0,135, upareni t-test; p = 0,114, Wilcoxonov test sume rangova).
Uncommon Back pain, joint swelling, muscle spasm, pain in extremity, plantar fasciitis 
Bol u leđima, oticanje zglobova, spazmi mišića, bol u ekstremitetima, plantarni fasciitis
In vitro studies evaluating the percent recovery of total dose delivered with nasogastric or gastrostomy tubes demonstrated the percent of dose recovered was >99% for doses > 1 ml and 70% for a 0.5 ml dose. 
In vitro ispitivanja za procjenu postotka povrata ukupne doze primijenjene putem nazogastrične sonde ili gastrostome pokazala su da je postotak povrata doze > 99% za doze > 1 ml, odnosno 70% za dozu od 0,5 ml.
In a separate study, in patients with hepatic impairment (Child-Pugh B and C), the ratios of mean values for PAA to PAGN among all patients dosed with 6 ml and 9 ml twice daily ranged from 0.96 to 1.28 and for patients dosed with 9 ml twice daily ranged from 1.18-3.19. 
U odvojenom ispitivanju, kod bolesnika s oštećenom jetrom (Child-Pugh B i C), omjeri srednjih vrijednosti PAA i PAGN kod bolesnika koji su primali doze od 6 ml i 9 ml dvaput dnevno bile su u rasponu od 0,96 do 1,28, i za bolesnike koji su primali dozu od 9 ml dvaput dnevno, bili su u rasponu od 1,18-3,19.
Following 4 ml of glycerol phenylbutyrate for 3 days (3 times a day [TID]), mean Cmax and AUC were 66 mcg/ml and 930 mcg•h/ml for PBA and 28 microgram /ml and 942 mcg•h/ml for PAA, 
Nakon davanja doze glicerolfenilbutrata od 4 ml tijekom 3 dana (3 puta dnevno), srednji Cmax i AUC bili su 66 μg/ml i 930 μg•h/ml za PBA, odnosno 28 mikrograma /ml i 942 μg•h/ml za PAA.
RAVICTI must be used with dietary protein restriction and, in some cases, dietary supplements (e.g., essential amino acids, arginine, citrulline, protein-free calorie supplements). 
RAVICTI se mora uzimati uz ograničen unos proteina prehranom i u nekim slučajevima, uz dodatke prehrani (npr. esencijalne aminokiseline, arginin, citrulin, kalorijske dodatke koji ne sadrže proteine).
There are limited data regarding the use of glycerol phenylbutyrate in pregnant women. 
Podaci o primjeni glicerolfenilbutirata u trudnica su ograničeni.
In healthy, fasting adult subjects receiving a single oral dose of 2.9 ml/m2 of glycerol phenylbutyrate, peak plasma levels of PBA, PAA, and PAGN occurred at 2 h, 4 h, and 4 h, respectively. 
Kod zdravih odraslih bolesnika koji natašte primaju jednu oralnu dozu od 2,9 ml/m2 glicerolfenilbutirata, vršne razine PBA, PAA i PAGN u plazmi postignute su nakon 2, 4, odnosno 4 sata.
Clinical studies in paediatric patients with UCDs 
Klinička ispitivanja u pedijatrijskih bolesnika s poremećajima ciklusa ureje
Clinical studies of RAVICTI did not include sufficient numbers of subjects ≥ 65 years of age to determine whether they respond differently than younger subjects. 
≥ 65 godina za utvrđivanje odgovaraju li oni drugačije na terapiju od mlađih ispitanika.
Chemical compatibility of glycerol phenylbutyrate with medical grade silicone nasogastric, gastrostomy, and nasojejunal tubes has been demonstrated. 
Dokazana je kemijska kompatibilnost glicerolfenilbutirata s nazogastričnim, gastrostomskim i nazojejunalnim sondama od silikona medicinskog stupnja.
RAVICTI 1.1 g/ml oral liquid 
RAVICTI 1,1 g/ml oralna tekućina
The daily dose should be individually adjusted according to the patient's protein tolerance and the daily dietary protein intake needed. 
Dnevnu dozu treba individualno prilagoditi prema bolesnikovom podnošenju proteina i potrebnom dnevnom unosu proteina prehranom.
The bottle is packed with a reclosable bottle cap adapter. 
Boca je pakirana s nastavkom za bocu s čepom za ponovno zatvaranje.
The efficacy of glycerol phenylbutyrate in paediatric patients 2 months to 17 years of age involving deficiencies of OTC, ASS, ASL, and ARG was evaluated in 2 fixed sequence, open-label, sodium phenylbutyrate to equivalent dosing of glycerol phenylbutyrate switchover studies (Studies 3 and 4). 
Djelotvornost glicerolfenlbutirata u pedijatrijskih bolesnika u dobi od 2 mjeseca do 17 godina uključujući nedostatak OTC-a, ASS-a, ASL-a i ARG-a procijenjena je u 2 otvorena ispitivanja fiksnog slijeda liječenja, s natrijevim fenilbutiratom, u usporedbi s ekvivalentnim doziranjem glicerolfenilbutirata (Ispitivanja 3 i 4).
Consistent with plasma ammonia, blood glutamine levels were lower during glycerol phenylbutyrate treatment as compared with sodium phenylbutyrate in each arm of the crossover study (decrease of 44.3 ± 154.43 micromol/L after glycerol phenylbutyrate compared with NaPBA; p = 0.064, paired t-test; p = 0.048, Wilcoxon signed-rank test). 
U skladu s razinom amonijaka u plazmi, razine glutamina u krvi bile su niže tijekom liječenja glicerolfenilbutiratom u usporedbi s natrijevim fenilbutiratom u svakoj skupini ukriženog ispitivanja (smanjenje od 44,3 ± 154,43 mikromola/l nakon glicerolfenilbutirata u usporedbi s NaPBA; p = 0,064, upareni t-test; p = 0,048, Wilcoxonov test sume rangova).
Based on prescribed dosing volume, patients should be advised to obtain CE marked oral syringes with suitable size for the dosage and compatible with the reclosable bottle cap adapter from the pharmacy. 
Ovisno o volumenu propisane doze bolesnicima se treba savjetovati da u ljekarni nabave oralne štrcaljke s oznakom CE, odgovarajuće veličine za dozu i kompatibilne s nastavkom za bocu s čepom za ponovno zatvaranje.
• if you have problems with your kidneys or liver - this is because glycerol phenylbutyrate is removed from your body through the kidneys and liver 
• ako imate problema s bubrezima ili jetrom - zbog toga što se glicerolfenilbutirat uklanja iz
The UCDs include deficiencies of carbamoyl phosphate synthetase I (CPS), ornithine carbamoyltransferase (OTC), argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL), arginase I (ARG) and ornithine translocase deficiency hyperornithinaemia-hyperammonaemia homocitrullinuria syndrome (HHH). 
Poremećaji ciklusa ureje uključuju nedostatak karbamoil fosfat sintetaze I (CPS), ornitin karbamoiltransferaze (OTC), argininosukcinat sintetaze (ASS), argininosukcinat liaze (ASL), arginaze I (ARG) i ornitin translokaze (sindrom hiperornitinemija-hiperamonemija-homocitrulinurija, HHH).