natgillin/translations-raw huggingface dataset:
In a study in healthy subjects, there was a decreased exposure by almost 40% of the active metabolite of clopidogrel when a fixed dose combination of esomeprazole 20 mg + acetylsalicylic acid 81 mg was given with clopidogrel compared to clopidogrel alone. 
U ispitivanju u zdravih ispitanika primijećeno je smanjenje izloženosti aktivnom metabolitu klopidogrela od gotovo 40% kada se uz klopidogrel davala fiksna kombinacija 20 mg esomeprazola + 81 mg acetilsalicilne kiseline u usporedbi s primjenom samo klopidogrela.
Concomitant administration of 30 mg esomeprazole resulted in a 45% decrease in clearance of the CYP2C19 substrate diazepam. 
Istodobna primjena 30 mg esomeprazola uzrokovala je 45% manji klirens diazepama, supstrata CYP2C19.
Reproductive system and breast disorders gynaecomastia 
Poremećaji reproduktivnog sustava i dojki ginekomastija
Blood and lymphatic system disorders leukopenia, thrombocytopenia agranulocytosis, pancytopenia 
Poremećaji krvi i limfnog sustava leukopenija, trombocitopenija agranulocitoza pancitopenija
Carcinogenicity studies in the rat with the racemic mixture have shown gastric ECL-cell hyperplasia and carcinoids. 
Ispitivanja kancerogenosti na štakorima uz primjenu racemične smjese ukazala su na hiperplaziju želučanih stanica nalik na enterokromafine stanice i karcinoide.
Esomeprazole must not be used concomitantly with nelfinavir (see section 4.5). 
Esomeprazol se ne smije primjenjivati istodobno s nelfinavirom (vidjeti dio 4.5).
Nervous system disorders headache dizziness, paraesthesia, somnolence taste disturbance 
Poremećaji živčanog sustava glavobolja omaglica, parestezije, somnolencija poremećaj okusa
You may experience symptoms such as diarrhoea, stomach ache, constipation, feeling or being sick and weakness. 
Mogli biste osjetiti simptome (kao što su proljev, bol u želucu, zatvor, mučnina ili povraćanje) i slabost.
These gastric effects in the rat are the result of sustained, pronounced hypergastrinaemia secondary to reduced production of gastric acid and are observed after long-term treatment in the rat with inhibitors of gastric acid secretion. 
Ove promjene su rezultat trajne izrazite hipergastrinemije koja je posljedica smanjenog lučenja želučane kiseline, a primijećene su nakon dugotrajne primjene inhibitora lučenja želučane kiseline u štakora.
Proton pump inhibitors are associated with very infrequent cases of SCLE. 
Subakutni kožni lupus eritematodes (engl. subacute cutaneous lupus erythematosus, SCLE) Inhibitori protonske pumpe povezani su s vrlo rijetkim slučajevima SCLE-a.
Nexium Control is indicated for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults. 
Nexium Control je indiciran za kratkotrajno liječenje simptoma refluksa (npr. žgaravice i regurgitacije želučane kiseline) u odraslih.
• Voriconazole (used to treat infections caused by a fungus) and clarithromycin (used to treat infections). 
• Vorikonazol (koristi se za liječenje gljivičnih infekcija) i klaritromicin (koristi se za liječenje infekcija).
You may need to take the capsules for 2-3 days in a row before you feel better. 
Kapsule ćete možda morati uzimati 2-3 dana zaredom prije nego što osjetite poboljšanje.
Medicinal products which induce CYP2C19 and/or CYP3A4 
Lijekovi koji induciraju CYP2C19 i/ili CYP3A4
Your doctor may need to monitor you when you start or stop taking Nexium Control 
Liječnik će Vas možda morati nadzirati kada započnete ili prekinete liječenje lijekom Nexium Control
• Suddenly feeling wheezy or short of breath (bronchospasm). 
• iznenadno piskanje pri disanju ili nedostatak zraka (bronhospazam)
Investigated medicinal products with no clinically relevant interaction Amoxicillin and quinidine 
Ispitivani lijekovi kod kojih ne dolazi do klinički značajne interakcije Amoksicilin i kinidin
In both studies esomeprazole 20 mg was significantly better compared to placebo for the primary endpoint, complete resolution of heartburn, defined as no heartburn episodes during the last 7 days prior to the final visit (33.9% - 41.6% vs. placebo 11.9 - 13.7%, (p<0.001). 
U oba je ispitivanja esomeprazol u dozi od 20 mg postigao značajno bolje rezultate u usporedbi s placebom u primarnoj mjeri ishoda, potpunom povlačenju žgaravice što se definira kao izostanak epizode žgaravice tijekom posljednjih 7 dana prije završnog posjeta (33,9%41,6% u odnosu na 11,9-13,7% u bolesnika koji su primali placebo, (p<0,001).
Musculoskeletal and connective tissue disorders arthralgia, myalgia muscular weakness 
Poremećaji mišićnokoštanog sustava i vezivnog tkiva artralgija, mialgija mišićna slabost
The co-administration of omeprazole (20 mg once a day) with atazanavir 400 mg/ritonavir 100 mg to healthy volunteers resulted in a decrease of approximately 30% in the atazanavir exposure as compared with the exposure observed with atazanavir 300 mg/ritonavir 100 mg once a day without omeprazole 20 mg once a day. 
Istodobna primjena omeprazola (20 mg jedanput na dan) i 400 mg atazanavira/100 mg ritonavira u zdravih dobrovoljaca dovela je do smanjenja izloženosti atazanaviru od približno 30% u usporedbi s izloženošću koja je primijećena kod primjene 300 mg atazanavira/100 mg ritonavira jedanput na dan bez omeprazola u dozi od 20 mg jedanput na dan.
Single doses of 80 mg esomeprazole were uneventful. 
Pojedinačne doze od 80 mg esomeprazola nisu uzrokovale simptome.
- You must talk to a doctor if you do not feel better or if you feel worse after 14 days. 
Pogledajte dio 4. - Obavezno se obratite liječniku ako se ne osjećate bolje ili ako se osjećate lošije nakon 14 dana.
• You are taking any medicines listed in the package leaflet. 
• Ako uzimate bilo koji lijek naveden u uputi o lijeku.
Gastric acid suppression during treatment with esomeprazole and other PPIs might decrease or increase the absorption of medicinal products with a gastric pH dependent absorption. 
Supresija želučane kiseline tijekom liječenja esomeprazolom i drugim inhibitorima protonske pumpe može smanjiti ili povećati apsorpciju lijekova kod kojih ona ovisi o pH.
This is because the capsule contains coated pellets, which stop the medicine from being broken down by the acid in your stomach. 
Naime, kapsule sadrže obložene pelete, koje sprječavaju kiselinu u želucu da razgradi lijek.
Treatment with PPIs may lead to slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter and in hospitalised patients, also possibly Clostridium difficile. 
Liječenje inhibitorima protonske pumpe može dovesti do blagog povećanja rizika od gastrointestinalnih infekcija, poput infekcija bakterijama Salmonella i Campylobacter, a u hospitaliziranih bolesnika i do moguće infekcije bakterijom Clostridium difficile.
Do not use this medicine after the expiry date which is stated on the carton and the bottle after EXP. 
Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i bočici iza oznake „Rok valjanosti“ i „EXP“.
Nexium Control contains the active substance esomeprazole. 
Nexium Control sadrži djelatnu tvar esomeprazol.
EU/1/13/860/001 7 gastro-resistant tablets EU/1/13/860/002 14 gastro-resistant tablets 
EU/1/13/860/001 7 želučanootpornih tableta EU/1/13/860/002 14 želučanootpornih tableta
However, post-marketing, a few isolated cases of elevated INR of clinical significance have been reported during concomitant treatment. 
Međutim, nakon stavljanja lijeka u promet, kod istodobnoga su liječenja prijavljeni izolirani klinički značajni slučajevi povećanoga INR-a.
Pfizer Gyógyszerkereskedelmi Kft. Consumer Healthcare Tel.: +36 1 488 37 00 
Consumer Healthcare Tel.: +36 1 488 37 00
Keep the container tightly closed to protect from moisture. 
Čuvati u čvrsto zatvorenoj bočici radi zaštite od vlage.
What Nexium Control contains - The active substance is esomeprazole. 
Što Nexium Control sadrži - Djelatna tvar je esomeprazol.
Esomeprazole has minor influence on the ability to drive or use machines. 
Esomeprazol slabo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
• You have severe kidney problems. 
• Ako imate teške probleme s bubrezima.
Dose adjustment is not required in patients with mild to moderate liver impairment. 
Nije potrebno prilagođavati dozu u bolesnika s blagim do umjerenim oštećenjem jetre.
Posology The recommended dose is 20 mg esomeprazole (one tablet) per day. 
Doziranje Preporučena doza je 20 mg esomeprazola (jedna tableta) na dan.
• Diazepam (used to treat anxiety, relax muscles or in epilepsy) 
• Diazepam (koristi se za liječenje tjeskobe, opuštanje mišića ili kod liječenja epilepsije)
• Diazepam (used to treat anxiety, relax muscles or in epilepsy). 
• Diazepam (koristi se za liječenje tjeskobe, opuštanje mišića ili kod liječenja epilepsije).
What Nexium Control looks like and contents of the pack Nexium Control 20 mg gastro-resistant tablets are light pink, oblong, biconvex, 14 mm x 7 mm, filmcoated, engraved with ‘20 mG' on one side and A/EH on the other side. 
Kako Nexium Control izgleda i sadržaj pakiranja Nexium Control 20 mg želučanootporne tablete su svijetloružičaste, ovalne, bikonveksne i filmom obložene, veličine 14 mm x 7 mm s utisnutom oznakom „20 mG“ na jednoj i „A/EH“ na drugoj strani.
• Put the tablet in a glass of still (non-fizzy) water. 
• Stavite tabletu u čašu negazirane vode.
Posology The recommended dose is 20 mg esomeprazole (one capsule) per day. 
Doziranje Preporučena doza je 20 mg esomeprazola (jedna kapsula) na dan.
Esomeprazole is metabolised by CYP2C19 and CYP3A4. 
Esomeprazol se metabolizira putem CYP2C19 i CYP3A4.
What Nexium Control looks like and contents of the pack Nexium Control 20 mg gastro-resistant hard capsules are approximately 11 x 5 mm capsules with a clear body, and an amethyst cap imprinted with “NEXIUM 20 MG” in white. 
Kako Nexium Control izgleda i sadržaj pakiranja Nexium Control 20 mg želučanootporne tvrde kapsule su kapsule veličine približno 11 x 5 mm s prozirnim tijelom i ljubičastom kapicom na kojoj je bijelom tintom otisnuto „NEXIUM 20 MG“.
The proportion of patients maintaining an intragastric pH above 4 for at least 8, 12 and 16 hours respectively were for esomeprazole 20 mg 76%, 54%, and 24%. 
Udio bolesnika u kojih je uz esomeprazol u dozi od 20 mg unutarželučani pH održan iznad vrijednosti 4 tijekom najmanje 8, 12 odnosno 16 sati iznosio je 76%, 54% odnosno 24%.
Concomitant administration of esomeprazole and a combined inhibitor of CYP2C19 and CYP3A4 may result in more than doubling of the esomeprazole exposure. 
Istodobna primjena esomeprazola i kombiniranog inhibitora CYP2C19 i CYP3A4 može više nego dvostruko povećati izloženost esomeprazolu.
You may need to take the tablets for 2-3 days in a row before you feel better. 
Tablete ćete možda morati uzimati 2-3 dana zaredom prije nego što osjetite poboljšanje.
• Sudden wheezing, swelling of your lips, tongue and throat, rash, fainting, or difficulties in swallowing (severe allergic reaction, seen rarely). 
• iznenadno piskanje pri disanju, oticanje usana, jezika i grla, osip, nesvjesticu ili otežano gutanje (teška alergijska reakcija, javlja se rijetko).
• Joint pain (arthralgia) or muscle pain (myalgia). 
• bol u zglobovima (artralgija) ili bol u mišićima (mijalgija)
Titanium dioxide (E171) 
talk titanijev dioksid (E171) trietilcitrat
Treatment with omeprazole 20 mg once a day had no effect on the exposure of darunavir (with concomitant ritonavir) and amprenavir (with concomitant ritonavir). 
Liječenje omeprazolom u dozi od 20 mg jedanput na dan nije utjecalo na izloženost darunaviru (primijenjenim zajedno s ritonavirom) niti amprenaviru (primijenjenim zajedno s ritonavirom).
No dose-related adverse reactions have been identified. 
Nisu primijećene nuspojave ovisne o dozi.
• Sudden wheezing, swelling of your lips, tongue and throat, rash, fainting or difficulties in swallowing (severe allergic reaction, seen rarely) 
• iznenadno piskanje pri disanju, oticanje usana, jezika i grla, osip, nesvjesticu ili otežano gutanje (teška alergijska reakcija, javlja se rijetko)
This is because the tablet contains coated pellets, which stop the medicine from being broken down by the acid in your stomach. 
Naime, tablete sadrže obložene pelete, koje sprječavaju kiselinu u želucu da razgradi lijek.
For atazanavir and nelfinavir, decreased serum levels have been reported when given together with omeprazole and concomitant administration is not recommended. 
Kad su se davali zajedno s omeprazolom, zabilježene su niže serumske razine atazanavira i nelfinavira pa se istodobna primjena ne preporučuje.
• The other ingredients are: glycerol monostearate 40-55, hydroxypropylcellulose, hypromellose, magnesium stearate, methacrylic acid - ethyl acrylate copolymer (1:1) dispersion 30 per cent, polysorbate 80, sugar spheres (sucrose and maize starch), talc, triethyl citrate, carmine (E120), indigo carmine (E132), titanium dioxide (E171), yellow iron oxide (E172), erythrosine (E127), allura red AC (E129), povidone K-17, propylene glycol, shellac, sodium hydroxide, and gelatin (see section 2, “Nexium Control contains sucrose”.) 
• Drugi sastojci su: glicerolmonostearat 40-55, hidroksipropilceluloza, hipromeloza, magnezijev stearat, metakrilatna kiselina- etilakrilat kopolimer (1:1); 30 postotna disperzija, polisorbat 80, šećerne kuglice (saharoza i kukuruzni škrob), talk, trietilcitrat, karmin (E120), bojilo Indigo carmine (E132), titanijev dioksid (E171), žuti željezov oksid (E172), bojilo Erythrosine (E127), bojilo Allura red AC (E129), povidon K-17, propilenglikol, šelak, natrijev hidroksid i želatina (Pogledajte dio 2, „Nexium Control sadrži saharozu”.)
Very rare (may affect up to 1 in 10,000 people) 
Vrlo rijetke (mogu se javiti u manje od 1 na 10 000 osoba):
• Citalopram, imipramine or clomipramine (used to treat depression) 
• Citalopram, imipramin ili klomipramin (koriste se za liječenje depresije)
Gastrointestinal disorders abdominal pain, constipation, diarrhoea, flatulence, nausea/ vomiting, fundic gland polyps (benign) 
Poremećaji probavnog sustava bol u abdomenu, konstipacija, proljev, flatulencija, mučnina/ povraćanje, polipi fundusnih žlijezda želuca (dobroćudni)
General disorders and administration site disorders malaise, increased sweating 
Opći poremećaji i reakcije na mjestu primjene malaksalost, pojačano znojenje
• Citalopram, imipramine or clomipramine (used to treat depression). 
• Citalopram, imipramin ili klomipramin (koriste se za liječenje depresije).
• Methotrexate (used to treat cancer and rheumatic disorders) 
• Metotreksat (koristi se za liječenje raka i reumatskih bolesti)
The pellets should not be chewed or crushed. 
Pelete se ne smiju žvakati niti drobiti.
Treatment with omeprazole 40 mg once a day had no effect on the exposure of lopinavir (with concomitant ritonavir). 
Liječenje omeprazolom u dozi od 40 mg jedanput na dan nije utjecalo na izloženost lopinaviru (primijenjenim zajedno s ritonavirom).
Esomeprazole is a CYP2C19 inhibitor. 
Esomeprazol je inhibitor CYP2C19.
The secondary endpoint of complete resolution of heartburn, defined as no heartburn on the patient's diary card for 7 consecutive days, was statistically significant at both week 1 (10.0% - 15.2% vs placebo 0.9% - 2.4%, p = 0.014, p<0.001) and week 2 (25.2% - 35.7% vs placebo 3.4% - 9.0%, p<0.001). 
Sekundarna mjera ishoda potpunog povlačenja žgaravice definirana kao izostanak žgaravice na bolesnikovoj kartici tijekom posljednjih 7 uzastopnih dana bila je statistički značajna i u 1. tjednu (10,0% do 15,2% u odnosu na 0,9%-2,4% u bolesnika koji su primali placebo, p=0,014, p<0,001) i u 2. tjednu (25,2%35,7% u odnosu na 3,4%-9,0% u bolesnika koji su primali placebo, p <0,001).
The normal symptoms of reflux are a painful sensation in the chest rising up to your throat (heartburn) and a sour taste in the mouth (acid regurgitation). 
Simptomi refluksa mogu biti osjećaj boli u prsnom košu koji se diže do grla (žgaravica) te kiseli okus u ustima (povrat kiseline).
Nexium Control contains sucrose 
Nexium Control sadrži saharozu
Nexium Control 20 mg Capsules 
Nexium Control 20 mg kapsule
Omeprazole, given in doses of 40 mg to healthy subjects in a cross-over study, increased Cmax and AUC for cilostazol by 18% and 26% respectively, and one of its active metabolites by 29% and 69% respectively. 
U ukriženom je ispitivanju primjena omeprazola u dozi od 40 mg u zdravih ispitanika povećala Cmax cilostazola za 18%, a njegov AUC za 26% te Cmax jednoga od aktivnih metabolita cilostazola za 29%, a njegov AUC za 69%.
The absorption of medicinal products taken orally such as ketoconazole, itraconazole and erlotinib can decrease during treatment with esomeprazole and the absorption of digoxin can increase during treatment with esomeprazole. 
Tijekom liječenja esomeprazolom apsorpcija lijekova uzimanih peroralno, poput ketokonazola, itrakonazola i erlotiniba, može se smanjiti, a apsorpcija digoksina povećati.
Reflux is the backflow of acid from the stomach into the gullet (“foodpipe”) which may become inflamed and painful. 
Refluks je vraćanje kiseline iz želuca u jednjak (cijev koja povezuje ždrijelo sa želucem), može uzrokovati upalu i bolnost zahvaćene sluznice.
About 80% of nights were heartburn free during all time periods and 90% of nights were heartburn free by week 2 of each clinical study, compared to 72.4 - 78.3% for placebo. 
U svim su vremenskim razdobljima ispitanici imali približno 80% noći bez žgaravice, a do drugog tjedna svakog kliničkog ispitivanja bez žgaravice je prošlo 90% noći u usporedbi sa 72,4-78,3% za placebo.
• Methotrexate (used to treat cancer and rheumatic disorders). 
• Metotreksat (koristi se za liječenje raka i reumatskih bolesti).
14 gastro-resistant hard capsules 
14 želučanootpornih tvrdih kapsula
Dose adjustment is not required in patients with impaired renal function. 
Nije potrebno prilagođavati dozu u bolesnika s oštećenom bubrežnom funkcijom.
• They are aged over 55 years with new or recently changed symptoms. 
• ako su stariji od 55 godina i imaju novonastale simptome ili su im se postojeći simptomi nedavno promijenili.
Esomeprazole is acid labile and is administered orally as enteric-coated granules. 
Esomeprazol je nestabilan u kiselom mediju stoga se peroralno primjenjuje u obliku želučanootpornih granula.
- The other ingredients are glycerol monostearate 40-55, hydroxypropylcellulose, hypromellose, reddish-brown iron oxide (E172), yellow iron oxide (E172), magnesium stearate, methacrylic acid ethylacrylate copolymer (1:1) dispersion 30 per cent, cellulose microcrystalline, synthetic paraffin, macrogol 6000, polysorbate 80, crospovidone (Type A), sodium stearyl fumarate, sugar spheres (sucrose and maize starch), talc, titanium dioxide (E171) and triethyl citrate (see section 2, “Nexium Control contains sucrose”). 
- Drugi sastojci su glicerolmonostearat 40-55, hidroksipropilceluloza, hipromeloza, crvenkastosmeđi željezov oksid (E172), žuti željezov oksid (E172), magnezijev stearat, metakrilatna kiselina-etilakrilat kopolimer (1:1); 30 postotna disperzija, mikrokristalična celuloza, sintetski parafin, makrogol 6000, polisorbat 80, krospovidon (vrsta A), natrijev stearilfumarat, šećerne kuglice (saharoza i kukuruzni škrob), talk, titanijev dioksid (E171) i trietilcitrat (pogledajte dio 2., „Nexium Control sadrži saharozu“).
Co-administration of omeprazole (40 mg once daily) with atazanavir 300 mg/ritonavir 100 mg to healthy volunteers resulted in a substantial reduction in atazanavir exposure (approximately 75% decrease in AUC, Cmax and Cmin). 
Istodobna primjena omeprazola (40 mg jedanput na dan) i 300 mg atazanavira/100 mg ritonavira u zdravih dobrovoljaca dovela je do značajnog smanjenja izloženosti atazanaviru (smanjenje AUC-a, Cmax i Cmin za približno 75%).
• Rifampicin (used to treat tuberculosis). 
• Rifampicin (koristi se za liječenje tuberkuloze).
• Erlotinib (used to treat cancer). 
• Erlotinib (koristi se za liječenje raka).
• Atazanavir, saquinavir (used to treat HIV infection) 
• Atazanavir, sakvinavir (koriste se za liječenje HIV infekcije)
• You have problems or pain when swallowing. 
• Ako otežano gutate ili osjećate bol pri gutanju.
• Rifampicin (used to treat tuberculosis) 
• Rifampicin (koristi se za liječenje tuberkuloze)
Co-administration of esomeprazole with atazanavir is not recommended (see section 4.5). 
Ne preporučuje se istodobna primjena esomeprazola i atazanavira (vidjeti dio 4.5).
Decreased gastric acidity due to any means including PPIs, increases gastric counts of bacteria normally present in the gastrointestinal tract. 
Ako se kiselost u želucu smanji zbog bilo kojeg uzroka, uključujući i inhibitore protonske pumpe, u želucu se povećava broj bakterija koje su i inače prisutne u probavnom sustavu.
- If you are taking a medicine containing nelfinavir (used to treat HIV infection). 
- ako uzimate lijek koji sadrži nelfinavir (koristi se za liječenje HIV infekcije).
Therefore, a maximum of 20 mg should not be exceeded in patients with severe dysfunction. 
Stoga se u bolesnika s teškim oštećenjem jetre ne smije prekoračiti maksimalna dnevna doza od 20 mg.
Treatment with esomeprazole 20 mg once a day had no effect on the exposure of amprenavir (with and without concomitant ritonavir). 
Liječenje esomeprazolom u dozi od 20 mg jedanput na dan nije utjecalo na izloženost amprenaviru (primijenjenim zajedno s ritonavirom ili bez njega).
• They have had previous gastric ulcer or gastrointestinal surgery. 
• ako su prethodno operirani zbog želučanog ulkusa ili bili podvrgnuti kirurškom zahvatu na gastrointestinalnom traktu.
This medicine is used in adults for the short-term treatment of reflux symptoms (for example, heartburn and acid regurgitation). 
Ovaj se lijek primjenjuje za kratkotrajno liječenje simptoma refluksa (primjerice, žgaravice i povrata želučane kiseline) u odraslih.
• Atazanavir, saquinavir (used to treat HIV infection). 
• Atazanavir, sakvinavir (koriste se za liječenje HIV infekcije).
Omeprazole as well as esomeprazole act as inhibitors of CYP2C19. 
Omeprazol, kao i esomeprazol, djeluje kao inhibitor CYP2C19.
Sodium hydroxide Titanium dioxide (E171) 
Tinta za označivanje povidon K-17 propilenglikol šelak natrijev hidroksid titanijev dioksid (E171)
Esomeprazole or its major metabolites do not show any tendency to accumulate with once-daily dosing. 
Ni esomeprazol ni njegovi glavni metaboliti nisu skloni kumulaciji kod primjene jedanput na dan.
• Erlotinib (used to treat cancer) 
• Erlotinib (koristi se za liječenje raka)
Concomitant administration of esomeprazole has been reported to increase the serum levels of tacrolimus. 
Prijavljeno je da istodobna primjena esomeprazola dovodi do povišenih koncentracija takrolimusa u serumu.
This may cause you symptoms such as a painful sensation in the chest rising up to your throat (heartburn) and a sour taste in the mouth (acid regurgitation). 
Refluks se manifestira simptomima poput boli u prsnom košu koja se podiže do grla (žgaravica) i kiselog okusa u ustima (povrat kiseline).
• If you are taking a medicine containing nelfinavir (used to treat HIV infection). 
• ako uzimate lijek koji sadrži nelfinavir (koristi se za liječenje HIV infekcije).
Concomitant administration of esomeprazole and a CYP3A4 inhibitor, clarithromycin (500 mg twice a day (b.i.d. 
Istodobna primjena esomeprazola i inhibitora CYP3A4, klaritromicina (500 mg dvaput na dan), udvostručila je izloženost (AUC) esomeprazolu.
• You should seek urgent medical advice if you experience chest pain with light-headedness, sweating, dizziness or shoulder pain with shortness of breath. 
• Odmah se obratite liječniku za savjet ako osjetite bol u prsnom košu uz ošamućenost, znojenje,
(the acid pump) and inhibits both basal and stimulated acid secretion. 
+K+-ATP-aze (protonske pumpe) te inhibira i bazalno i stimulirano lučenje kiseline.
The metabolic rate is decreased in patients with severe liver dysfunction resulting in a doubling of the area under the plasma concentration-time curve of esomeprazole. 
U bolesnika s teškim oštećenjem jetre metabolizam esomeprazola je smanjen, što dovodi do udvostručenja površine ispod krivulje.
• Benign growths (polyps) in the stomach. 
• dobroćudni polipi u želucu.
The use of esomeprazole with clopidogrel should be discouraged (see section 4.5). 
Treba izbjegavati primjenu esomeprazola s klopidrogelom (vidjeti dio 4.5).