natgillin/translations-raw huggingface dataset:
Zoledronic acid medac zoledronic acid 
Zoledronatna kiselina medac zoledronatna kiselina
Zoledronic acid medac can be used to prevent bone complications in adults with advanced cancer that is affecting the bone. 
Zoledronatna kiselina medac koristiti za sprječavanje koštanih komplikacija u odraslih osoba s uznapredovalim rakom kostiju koji zahvaća kost.
The Committee recommended that Zoledronic acid medac be given marketing authorisation. 
Odbor je preporučio izdavanje odobrenja za stavljanje u promet lijeka Zoledronatna kiselina medac.
What are the benefits and risks of Zoledronic acid medac? 
Koje su koristi i rizici od lijeka Zoledronatna kiselina medac?
The active substance in Zoledronic acid medac, zoledronic acid, is a bisphosphonate. 
Djelatna tvar u lijeku Zoledronatna kiselina medac, zoledronatna kiselina, je bisfosfonat.
Other information about Zoledronic acid medac 
Ostale informacije o lijeku Zoledronatna kiselina medac
When used to prevent bone complications, the infusion can be repeated every three to four weeks, and patients should also take supplements of calcium and vitamin D. A lower dose is recommended for patients with bone metastases (when cancer has spread to the bone) if they have mild to moderate problems with their kidneys. 
Ako se koristi za sprječavanje komplikacija kosti, infuzija se može ponoviti svaka tri do četiri tjedna, a bolesnik treba također uzimati dodatke kalcija i vitamina D.
Zoledronic acid medac is a medicine that contains the active substance zoledronic acid. 
Zoledronatna kiselina medac je lijek koji sadrži zoledronatnu kiselinu kao djelatnu tvar.
Why has Zoledronic acid medac been approved? 
Zašto je lijek Zoledronatna kiselina medac odobren?
By preventing the breakdown of bones, Zoledronic acid medac also helps to reduce the amount of calcium released into the blood. 
Zoledronatna kiselina medac također doprinosi snižavanju količine kalcija koja se oslobađa u krv time što sprječava razgradnju kostiju.
What is Zoledronic acid medac? 
Što je Zoledronatna kiselina medac?
What is Zoledronic acid medac used for? 
Za što se Zoledronatna kiselina medac koristi?
How does Zoledronic acid medac work? 
Kako djeluje Zoledronatna kiselina medac?
How is Zoledronic acid medac used? 
Kako se koristi Zoledronatna kiselina medac?
How has Zoledronic acid medac been studied? 
Kako je lijek Zoledronatna kiselina medac ispitivan?
It is taken once a day, consistently either in the morning or in the evening. 
Uzima se jednom dnevno, dosljedno ili ujutro ili uvečer.
Further information on Sprycel can be found on the Agency's website ema.europa.eu/medicines/human/EPAR/Sprycel. 
Više informacija o lijeku Sprycel nalazi se na internetskim stranicama Agencije ema.europa.eu/medicines/human/EPAR/Sprycel.
The dose is then gradually increased until the disease is controlled well enough. 
Doza se zatim postupno povećava sve dok bolest ne bude pod dostatnom kontrolom.
Sprycel is also used in children to treat: 
Sprycel se također primjenjuje za liječenje djece:
Such events were: any sign of the disease in bone marrow, return of the disease anywhere in the body, a second cancer or death. 
Ti su događaji sljedeći: bilo kakav znak bolesti koštane srži, povratak bolesti bilo gdje u tijelu, drugi rak ili smrt.
What measures are being taken to ensure the safe and effective use of Sprycel? 
Koje se mjere poduzimaju kako bi se osigurala sigurna i učinkovita primjena lijeka Sprycel?
The doses for Sprycel tablets and suspension are not the same. 
Doze za tablete Sprycel i za suspenziju nisu jednake.
The main measure of effectiveness was the proportion of patients who did not have an unwanted event within 3 years of treatment. 
Glavna mjera učinkovitosti bio je udio bolesnika kod kojih se nije pojavio neželjen događaj u roku od 3 godine nakon liječenja.
The starting dose depends on the condition being treated and, for children, their body weight. 
Početna doza ovisi o stanju koje se liječi, a kod djece o njihovoj tjelesnoj težini.
Sprycel is available as tablets (20, 50, 70, 80, 100 and 140 mg) and a powder to make up a suspension (10 mg/ml) to be taken by mouth. 
Sprycel je dostupan u obliku tableta (20, 50, 70, 80, 100 i 140 mg) i kao prašak za suspenziju (10 mg/ml) koja se uzima na usta.
Other information about Sprycel 
Ostale informacije o lijeku Sprycel
Among patients treated with Sprycel and chemotherapy, 66% did not have an unwanted event. 
Među bolesnicima koji su primali lijek Sprycel i kemoterapiju, 66 % njih nije imalo neželjen događaj.
What are the risks associated with Sprycel? 
Koji su rizici povezani s lijekom Sprycel?
The most common side effects with Sprycel (seen in more than 1 patient in 10) are infection, suppression of the bone marrow (decreasing numbers of blood cells), headache, haemorrhage (bleeding), pleural effusion (fluid around the lungs), dyspnoea (difficulty breathing), diarrhoea, vomiting, nausea (feeling sick), abdominal pain (belly ache), skin rash, musculoskeletal pain, tiredness, swelling in the legs and arms and in the face, fever. 
Najčešće nuspojave lijeka Sprycel (zabilježene u više od 1 na 10 osoba) jesu infekcija, supresija koštane srži (smanjenje broja krvnih stanica), glavobolja, hemoragija (krvarenje), pleuralni izljev (tekućina oko pluća), dispneja (poteškoće s disanjem), proljev, povraćanje, mučnina, bol u abdomenu (trbuhu), kožni osip, mišićno-koštani bol, umor, oticanje udova i lica, vrućica.
Side effects reported with Sprycel are carefully evaluated and any necessary action taken to protect patients. 
Nuspojave prijavljene za lijek Sprycel pažljivo se procjenjuju i poduzimaju se potrebne mjere za zaštitu bolesnika.
What is Sprycel and what is it used for? 
Što je Sprycel i za što se primjenjuje?
By blocking Bcr-Abl kinase, as well as other kinases, Sprycel helps to reduce the number of leukaemia cells. 
Blokiranjem Bcr-Abl kinaze, kao i drugih kinaza, Sprycel pomaže u smanjenju broja leukemijskih stanica.
This enzyme is produced by leukaemia cells, and causes them to multiply uncontrollably. 
Taj enzim proizvode leukemijske stanice te on uzrokuje njihovo nekontrolirano množenje.
In addition, the number of white blood cells containing the Philadelphia chromosome was reduced in around 33 to 66% of treated patients in the five main studies. 
Nadalje, broj leukocita koji su sadržavali Philadelphia kromosom smanjio se za od oko 33 do 66 % liječenih bolesnika u pet glavnih ispitivanja.
• CML in ‘chronic', ‘accelerated' and ‘blast' phases. 
• KML-om u „kroničnoj”, „ubrzanoj” i „blastičnoj” fazi.
Sprycel received a marketing authorisation valid throughout the European Union on 20 November 
Lijek Sprycel dobio je odobrenje za stavljanje u promet koje je na snazi u EU-u od 20. studenoga
The European Medicines Agency decided that Sprycel's benefits are greater than its risks and it can be authorised for use in the EU. 
Europska agencija za lijekove zaključila je da koristi od lijeka Sprycel nadmašuju s njim povezane rizike te da lijek može biti odobren za primjenu u Europskoj uniji.
Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Sprycel have been included in the summary of product characteristics and the package leaflet. 
Preporuke i mjere opreza kojih se zdravstveni radnici i bolesnici trebaju pridržavati u cilju sigurne i učinkovite primjene lijeka Sprycel nalaze se u sažetku opisa svojstava lijeka i u uputi o lijeku.
Treatment is stopped if the medicine no longer controls the condition or if the patient cannot take the medicine because of side effects. 
Liječenje se trajno prekida ako se lijekom više ne može kontrolirati stanje ili ako bolesnik ne može uzimati lijek zbog nuspojava.
Sprycel was more effective than imatinib: within one year, 77% of patients receiving Sprycel no longer had the Philadelphia chromosome in their blood cells, compared with 66% of patients receiving imatinib. 
Lijek Sprycel bio je učinkovitiji od imatiniba: u roku od jedne godine 77 % bolesnika koji su primali lijek Sprycel nisu više imali Philadelphia kromosom u krvnim stanicama u usporedbi sa 66 % bolesnika koji su primali imatinib.
None of these studies compared Sprycel with another medicine. 
Ni u jednom od tih ispitivanja lijek Sprycel nije se usporedio s nekim drugim lijekom.
Sprycel can only be obtained with a prescription and treatment should be started by a doctor who has experience in the diagnosis and treatment of leukaemia. 
Sprycel se izdaje samo na liječnički recept, a liječenje mora započeti liječnik s iskustvom u dijagnosticiranju i liječenju leukemije.
Why is Sprycel authorised in the EU? 
Zašto je lijek Sprycel odobren u EU-u?
The doctor may reduce the dose or interrupt treatment if blood cell counts are too low or certain side effects occur. 
Liječnik može smanjiti dozu ili privremeno prekinuti liječenje ako je broj krvnih stanica prenizak ili ako se pojave određene nuspojave.
In children with ALL who are also receiving other cancer medicines, a fixed dose of Sprycel is used throughout their treatment. 
U djece s ALL-om koja primaju i druge lijekove protiv raka primjenjuje se fiksna doza lijeka Sprycel tijekom cijelog vremena njihova liječenja.
Dasatinib acts mainly by blocking the Bcr-Abl protein kinase. 
Dasatinib većinom djeluje tako da blokira Bcr-Abl protein-kinaze.
An overview of Sprycel and why it is authorised in the EU 
Pregled informacija o lijeku Sprycel i zašto je odobren u EU-u
Once- and twice-daily Sprycel had similar effectiveness, but the once-daily dose caused fewer side effects. 
Sprycel primijenjen jednom ili dvaput dnevno imao je sličnu učinkovitost, no doza primijenjena jednom dnevno uzrokovala je manje nuspojava.
• chronic myeloid leukaemia (CML) in the ‘chronic' phase in newly diagnosed patients who are ‘Philadelphia chromosome positive' (Ph+). 
• kroničnom mijeloičnom leukemijom (KML) u „kroničnoj” fazi u bolesnika s novodijagnosticiranom bolesti koji su „pozitivni na Philadelphia kromosom” (Ph+).
• newly diagnosed Ph+ ALL in combination with chemotherapy (cancer medicines). 
• s novodijagnosticiranim Ph+ ALL-om u kombinaciji s kemoterapijom (lijekovi protiv raka).
Ph+ means that some of the patient's genes have rearranged themselves to form a special chromosome called the Philadelphia chromosome which produces an enzyme, Bcr-Abl kinase that leads to the development of leukaemia. 
Ph+ znači da su se neki od bolesnikovih gena prerasporedili i stvorili poseban kromosom zvan Philadelphia kromosom koji proizvodi enzim, BcrAbl kinazu, koji uzrokuje razvoj leukemije;
Most of these studies assessed how well the leukaemia responded to treatment by measuring the levels of white cells and platelets in the blood, to see if they were returning to within normal levels, and by measuring the number of white blood cells that contained the Philadelphia chromosome, to see if it was decreasing. 
U većini tih ispitivanja procjenjivalo se koliko je dobro leukemija odgovorila na liječenje tako što se mjerila razina leukocita i trombocita u krvi kako bi se vidjelo vraćaju li se na normalne vrijednosti te broj leukocita koji su sadržavali Philadelphia kromosom kako bi se vidjelo smanjuje li se.
As for all medicines, data on the use of Sprycel are continuously monitored. 
Kao i za sve lijekove, podatci o primjeni lijeka Sprycel kontinuirano se prate.
In patients with CML in other phases (accelerated, myeloid blast and lymphoid blast) and in ALL, around 25 to 33% of the patients had complete response. 
U bolesnika s KML-om u drugim fazama (ubrzana, mijeloblastična i limfoblastična) te u bolesnika s ALL-om, za od oko 25 do 33 % njih odgovor je bio potpun.
The active substance in Sprycel, dasatinib, belongs to a group of medicines that block enzymes known as protein kinases. 
Djelatna tvar u lijeku Sprycel, dasatinib, pripada skupini lijekova koji inhibiraju enzime pod nazivom protein-kinaze.
In comparison, using results of previous studies, the figure was 49% in patients who had received chemotherapy alone and 59% in patients who had received imatinib and chemotherapy. 
Za usporedbu, rezultati prethodnih ispitivanja upućuju na to da je ta brojka iznosila 49 % u bolesnika koji su primali samo kemoterapiju te 59 % u bolesnika koji su primali imatinib i kemoterapiju.
In a study involving 106 children and adolescents with newly diagnosed Ph+ ALL, patients were treated with Sprycel and chemotherapy. 
U ispitivanju kojim je bilo obuhvaćeno 106 djece i adolescenata s novodijagnosticiranim Ph+ ALL-om, bolesnici su liječeni lijekom Sprycel i kemoterapijom.
For more information about using Sprycel, see the package leaflet or contact your doctor or pharmacist. 
Više informacija o primjeni lijeka Sprycel pročitajte u uputi o lijeku, odnosno obratite se liječniku ili ljekarniku.
Sprycel is used when other treatments including imatinib (another cancer medicine) do not work or cause troublesome side effects; 
Sprycel se primjenjuje kada druga liječenja, uključujući imatinibom (drugim lijekom protiv raka), ne djeluju ili uzrokuju ozbiljne nuspojave;
The five main studies of Sprycel in adults involved 515 patients, all of whom had received treatment with imatinib, which had not worked or had stopped working. 
U pet glavnih ispitivanja lijeka Sprycel u odraslih osoba bilo je uključeno 515 bolesnika koji su svi prethodno primali liječenje imatinibom koje nije djelovalo ili je prestalo djelovati.
• Ph+ acute lymphoblastic leukaemia (ALL), where lymphocytes (another type of white blood cell) multiply too quickly, or in ‘lymphoid blast' CML. 
• Ph+ akutnom limfoblastičnom leukemijom (ALL) u kojoj se limfociti (druga vrsta bijelih krvnih stanica) prebrzo množe ili limfoblastičnim KML-om.
In CML, granulocytes (a type of white blood cell) start growing out of control. 
U oboljelih od KML-a granulociti (vrsta bijelih krvnih stanica) počinju nekontrolirano rasti.
Sprycel is a cancer medicine. 
Sprycel je lijek protiv raka.
A response was seen in around 90% of patients who could not use imatinib or it had not worked, and in 94% of newly diagnosed patients. 
Odgovor je utvrđen u oko 90 % bolesnika koji nisu mogli uzimati imatinib ili kod kojih imatinib nije djelovao te u 94 % bolesnika s novodijagnosticiranom bolesti.
How does Sprycel work? 
Kako djeluje Sprycel?
Sprycel is used when other treatments do not work or cause troublesome side effects. 
Sprycel se primjenjuje kada druga liječenja ne djeluju ili uzrokuju ozbiljne nuspojave.
Sprycel contains the active substance dasatinib. 
Sprycel sadržava djelatnu tvar dasatinib.
Two studies were in patients with chronic CML (198 and 36 patients), one was in accelerated CML (120 patients), one was in myeloid blast CML (80 patients), and one was in Ph+ ALL and lymphoid blast CML (81 patients). 
Dva su ispitivanja provedena na bolesnicima s kroničnim KML-om (198 i 36 bolesnika), jedno je uključivalo bolesnike s ubrzanim KML-om (120 bolesnika), jedno ispitivanje obuhvatilo je bolesnike s mijeloblastičnim KML-om (80 bolesnika) te jedno bolesnike s Ph+ ALL-om i limfoblastičnim KML-om (81 bolesnik).
Another main study looked at the effectiveness of Sprycel in 113 children with Ph+ chronic phase CML, including 29 patients who could not use imatinib or it had not worked, as well as 84 newly diagnosed children who had not been previously treated. 
U još jednom glavnom ispitivanju ispitana je učinkovitost lijeka Sprycel u 113 djece s Ph+ KML-om u kroničnoj fazi, uključujući 29 bolesnika u kojih se nije mogao primijeniti imatinib ili kod kojih imatinib nije djelovao, kao i 84 djece s novodijagnosticiranom bolesti koja prethodno nisu bila liječena.
• newly diagnosed Ph+ CML in the ‘chronic' phase, or Ph+ CML when other treatments including imatinib cannot be given or have not worked; 
• s novodijagnosticiranim Ph+ KML-om u „kroničnoj” fazi ili djece koja imaju Ph+ KML kada ne mogu primiti drugo liječenje, uključujući imatinib, ili kada drugo liječenje ne djeluje;
In the larger main study of patients with chronic phase CML, blood levels of platelets and white blood cells returned to within normal values in 90% of the patients. 
U većem glavnom ispitivanju bolesnika s KML-om u kroničnoj fazi broj trombocita i leukocita vratio se na normalne vrijednosti u 90 % bolesnika.
What benefits of Sprycel have been shown in studies? 
Koje su koristi lijeka od Sprycel utvrđene u ispitivanjima?
A further study involving 519 patients compared Sprycel with imatinib in treating newly diagnosed Ph+ patients with chronic phase CML who had not received any previous treatment. 
U daljnjem ispitivanju, koje je uključivalo 519 bolesnika, uspoređen je lijek Sprycel s imatinibom u liječenju bolesnika s novodijagnosticiranim Ph+ KML-om u kroničnoj fazi koji prethodno nisu bili liječeni.
For the full list of side effects and restrictions with Sprycel, see the package leaflet. 
Potpuni popis nuspojava i ograničenja zabilježenih prilikom primjene lijeka Sprycel potražite u uputi o lijeku.
How is Sprycel used? 
Kako se Sprycel primjenjuje?
Two further studies compared the effects of Sprycel taken once or twice a day, one in 670 patients with chronic phase CML and the other in 611 patients with advanced phase CML or Ph+ ALL. 
Jedno je ispitivanje uključivalo 670 bolesnika s KML-om u kroničnoj fazi, a drugo 611 bolesnika s KML-om u uznapredovaloj fazi ili Ph+ ALL-om.
Blood transfusions were rarely required. 
Transfuzije krvi bile su rijetko potrebne.
Other incompatibilities may also exist. 
Mogu postojati i druge inkompatibilnosti.
- age over 75 years 
• dob veća od 75 godina
Each pack contains: 
Svako pakiranje sadrži:
2 needles 19 G1 
2 igle 19 G1
• if you have had external heart massage within the past 10 days. 
• ako ste imali vanjsku masažu srca u posljednjih 10 dana
Do not add any other medicines. 
Nemojte dodavati neke druge lijekove.
20014 Nerviano (Milan) Italy 
20014 Nerviano (Milan) Italija
Therefore tell the medical staff immediately if you 
Stoga odmah obavijestite medicinsko osoblje ako
10 U reteplase 
10 U reteplaze
Use aseptic technique throughout. 
Cijelo vrijeme primjenjujte aseptičku tehniku.
Therefore it should not be used except in life-threatening situations. 
Stoga se ne smije primjenjivati, osim u situacijama opasnima po život.
Date of first authorisation: 29 August 1996 Date of last renewal: 29 August 2006 
Datum posljednje obnove: 29. kolovoza 2006.
Rapilysin is usually given in a hospital. 
Rapilysin se uglavnom daje u bolnici.
For further information see section 4.4, section bleeding. 
Za dodatne informacije vidjeti dio 4.4, dio o krvarenju.
These events can be life-threatening and may lead to death. 
Ti događaji mogu biti opasni po život i mogu uzrokovati smrt.
Injury, poisoning and procedural 
Ozljede, trovanja i proceduralne komplikacije
This leaflet was last revised in <{MM/YYYY}> 
Ova uputa je zadnji puta revidirana u {MM/GGGG}
It is given within 12 hours after the onset of symptoms. 
Primjenjuje se unutar 12 sati od pojave simptoma.
52, Rue Marcel et Jacques Gaucher 94120 Fontenay-Sous-Bois France 
52, Rue Marcel et Jacques Gaucher 94120 Fontenay-Sous-Bois Francuska
If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user. 
Ako se ne primijeni odmah, vrijeme čuvanja i uvjeti prije uporabe odgovornost su korisnika.
The fibrinogen level normalises within 2 days. 
Razina fibrinogena normalizira se tijekom 2 dana.
• any other condition in which bleeding might be especially dangerous or might occur at a site where it would be difficult to control 
• bilo koje drugo stanje u kojem krvarenje može biti osobito opasno ili se može pojaviti na mjestu koje je teško nadzirati.
1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from the available data). 
1/1000), vrlo rijetko (< 1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
Instructions for use/handling 
Upute za uporabu/rukovanje
• if you have severe uncontrolled high blood pressure (hypertension). 
• ako imate teški, nekontrolirani, povišeni krvni tlak (hipertenziju)
As with other plasminogen activators a rebound phenomenon then occurs during which fibrinogen levels reach a maximum within 9 days and remain elevated for up to 18 days. 
Kao i kod drugih aktivatora plazminogena dolazi do fenomena povratne sprege tijekom kojega razina fibrinogena dostiže maksimum u razdoblju od 9 dana i ostaje povišena i do 18 dana.
Be sure to tell hospital staff immediately if any of these symptoms appear. 
Odmah obavijestite medicinsko osoblje ako se javi bilo koji od ovih simptoma.
• if you have in the past 3 months had severe bleeding, a major injury or major surgery (e.g. 
• ako ste u posljednja 3 mjeseca imali teško krvarenje, veću ozljedu ili veći kirurški zahvat (npr.
In case of incompatibility an adaptor can be used and removed together with the glass syringe immediately after administration 
U slučaju inkompatibilnosti može se primijeniti adapter i ukloniti zajedno sa staklenom štrcaljkom odmah nakon primjene.
Each injection should be given slowly within 2 minutes. 
Svaka se injekcija mora ubrizgavati polako, u trajanju od 2 minute.
The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent published on the European medicines web-portal. 
Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenim člankom 107(c) stavkom 7 Direktive 2001/83/EZ i svim sljedećim nadopunama objavljenim na europskom internetskom portalu za lijekove.
The risks of Rapilysin treatment may be increased if you have any of the following conditions: 
Rizici liječenja lijekom Rapilysin mogu se povećati ako imate neko od sljedećih stanja:
This medicinal product should not be mixed with Heparin and/or acetylsalicylic acid. 
Ovaj lijek se ne smije miješati s heparinom i/ili acetilsalicilatnom kiselinom.
The risk of intracranial bleeding and fatal intracranial bleeding increases with increasing age. 
Rizik od intrakranijalnog krvarenja i smrtonosnog intrakranijalnog krvarenja povećava se s dobi.
After reconstitution (“when dissolved”), the solution must be used immediately. 
Nakon pripreme za primjenu („kada je otopljena“), otopina se mora odmah primijeniti.
• if you have other tumours associated with an increased risk of bleeding. 
• ako imate druge tumore povezane s povećanim rizikom od krvarenja
Reconstituted product: 
Rekonstituirani lijek:
* Potency of reteplase is expressed in units (U) by using a reference standard which is specific for reteplase and is not comparable with units used for other thrombolytic agents. 
* Jakost reteplaze izražava se u jedinicama (U) korištenjem referentnog standarda koji je specifičan za reteplazu i ne može se uspoređivati s jedinicama korištenim za druge trombolitičke lijekove.
Contents of the pack and other information What Rapilysin contains 
Sadržaj pakiranja i druge informacije Što Rapilysin sadrži
• if you are allergic to reteplase or any of the other ingredients of this medicine (listed in section 
• ako ste alergični na reteplazu ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.)
The only relevant available animal data refer to studies performed in rabbits, which showed vaginal bleedings associated with abortions (see section 5.3). 
Jedini dostupni relevantni podaci dobiveni ispitivanjima na životinjama odnose se na ispitivanja provedena na kunićima koja su pokazala pojavu vaginalnog krvarenje povezanog s pobačajima (vidjeti dio 5.3).
White powder and clear colourless liquid (water for injections). 
Bijeli prašak i bistra bezbojna tekućina (voda za injekcije).
In the event of overdosage one might expect depletion of fibrinogen and other blood coagulation components (e.g. coagulation factor V) with a consequent risk of bleeding. 
U slučaju predoziranja može se očekivati deplecija fibrinogena i drugih komponenti zgrušavanja krvi (npr. koagulacijski faktor V), s posljedičnim rizikom od krvarenja.
In the alteplase group 33.0 % were fatal and 39.8 % were disabling. 
U skupini koja je primala alteplazu 33,0% bilo je smrtonosno, a 39,8% uzrokovalo je invalidnost.
Hypersensitivity reactions (e.g. allergic reactions)1 
Reakcije preosjetljivosti (primjerice, alergijske reakcije)1