natgillin/translations-raw huggingface dataset:
The requirements for submission of periodic safety update reports for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal. 
Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i objavljeni na europskom internetskom portalu za lijekove.
Renal clearance is about 250-300 ml/min. 
Renalni klirens je oko 250-300 ml/min.
- Medicines to increase blood pressure, such as noradrenaline. 
- lijekovi za povišenje krvnog tlaka kao što je noradrenalin.
- Calcium supplements and/or vitamin D supplements. 
- nadomjesci kalcija i/ili nadomjesci vitamina D.
This applies especially to the medicines listed below taken at the same time with Actelsar HCT: 
Ovo se osobito odnosi na lijekove navedene u nastavku koji se uzimaju istodobno uz Actelsar HCT:
- Lithium containing medicines to treat some types of depression. 
- lijekovi koji sadrže litij za liječenje određenih oblika depresije.
“Lot”, which is printed on the carton, refers to the batch number. 
"Lot" koji je ispisan na kutiji odnosi se na broj serije.
If you take more Actelsar HCT than you should 
Ako uzmete više Actelsar HCT nego što ste trebali
Date of first authorisation: 13 March 2013 Date of latest renewal: 
Datum prvog odobrenja: 13. ožujka 2013.
Plasma concentrations of telmisartan are generally 2-3 times higher in females than in males. 
Koncentracije telmisartana u plazmi su općenito 2-3 puta veće kod žena nego kod muškaraca.
The overall incidence of adverse reactions reported with telmisartan (41.4%) was usually comparable to placebo (43.9%) in placebo controlled trials. 
Ukupna incidencija nuspojava prijavljenih uz telmisartan (41,4%) obično je bila usporediva s placebom (43,9%) u placebom kontroliranim ispitivanjima.
Whilst there is no controlled epidemiological data on the risk with angiotensin II receptor antagonists, similar risks may exist for this class of medicinal products. 
Iako ne postoje kontrolirani epidemiološki podaci o riziku uz antagoniste receptora angiotenzina II, slični rizici mogu postojati za ovu skupinu lijekova.
Hydrochlorothiazide is 68% protein bound in the plasma and its apparent volume of distribution is 0.83-1.14 l/kg. 
Hidroklorotiazid se 68% veže na proteine u plazmi, a njegov prividni volumen distribucije je 0,831,14 l/kg.
Actelsar HCT is not recommended for mothers who are breast-feeding and your doctor may choose another treatment for you if you wish to breast-feed. 
Actelsar HCT se ne preporučuje majkama koje doje, a liječnik može odabrati drugo liječenje za Vas ako želite dojiti.
What Actelsar HCT is and what it is used for 
Što je Actelsar HCT i za što se koristi
Telmisartan is highly bound to plasma proteins (>99.5%) mainly albumin and alpha l-acid glycoprotein. 
Telmisartan se uvelike veže na proteine plazme (>99,5%), uglavnom albumin i alfa 1 kiseli glikoprotein.
Protect your skin from sun exposure and UV rays while taking Actelsar HCT 
Zaštitite svoju kožu od izlaganja suncu i UV zrakama za vrijeme uzimanja Actelsara HCT.
- Cholestyramine and colestipol, medicines for lowering blood fat levels. 
- kolestiramin i kolestipol, lijekovi za snižavanje vrijednosti masnoća u krvi.
Actelsar HCT can have influence on the ability to drive and use machines. 
Actelsar HCT može utjecati na sposobnost upravljanja vozilima i rada sa strojevima.
Talk to your doctor before taking Actelsar HCT if you are suffering or have ever suffered from any of the following conditions or illnesses: 
Obratite se svom liječniku prije nego uzmete Actelsar HCT ako bolujete ili ste bolovali od nekih od sljedećih stanja ili bolesti:
Do not use this medicine after the expiry date which is stated on the carton, blister or bottle label after “EXP”. 
Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji, blisteru ili bočici iza oznake „EXP“.
Do not store above 30ºC 
Ne čuvati na temperaturi iznad 30°C.
Increase in dose of probenecid or sulfinpyrazone may be necessary. 
Povećanje doze probenecida ili sulfinpirazona može se pokazati nužnim.
Based on cumulative renal excretion of hydrochlorothiazide the absolute bioavailability was about 60%. 
Na osnovi kumulativne renalne ekskrecije hidroklorotiazida, apsolutna bioraspoloživost bila je oko 60%.
(≥1/10,000 to <1/1,000). 
do <1/1000).
You can take Actelsar HCT with or without food. 
Možete uzimati Actelsar HCT s ili bez hrane.
If a re-administration of the diuretic is deemed necessary, it is recommended to protect exposed areas to the sun or to artificial UVA. 
Ako se ponovna primjena diuretika smatra potrebnom, preporučuje se zaštita dijelova izloženih suncu ili umjetnom UVA zračenju.
If any of the above applies to you, tell your doctor or pharmacist before taking Actelsar HCT. 
Ako se nešto od gore navedenog odnosi na Vas, obratite se liječniku ili ljekarniku prije nego počnete uzimati Actelsar HCT.
You should consult with your doctor if you need to adjust the dose of your other medicine while taking Actelsar HCT. 
Potrebno je savjetovati se s liječnikom ako trebate prilagođavanje doze drugog lijeka dok uzimate Actelsar HCT.
See also information under the heading “Do not take Actelsar HCT”. 
Vidjeti također informacije pod naslovom „Nemojte uzimati Actelsar HCT“.
Your doctor will normally advise you to stop taking Actelsar HCT before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Actelsar HCT. 
Liječnik će Vam, u redovnom slučaju, savjetovati prekid primjene Actelsara HCT prije nego budete trudni ili čim saznate da ste trudni, te će Vam preporučiti drugi lijek umjesto Actelsara HCT.
- Muscle relaxing medicines, such as tubocurarine. 
- lijekovi za opuštanje mišića kao što je tubokurarin.
Contents of the pack and other information What Actelsar HCT contains 
Sadržaj pakiranja i druge informacije Što Actelsar HCT sadrži
The effects of fixed dose combination of telmisartan/HCT on mortality and cardiovascular morbidity are currently unknown. 
Učinci kombinacije fiksne doze telmisartana/HCT-a na smrtnost i kardiovaskularni morbiditet su trenutno nepoznati.
- If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take Actelsar HCT” and “Warnings and precautions”). 
- ako uzimate ACE inhibitor ili aliskiren (vidjeti također informacije pod naslovima „Nemojte uzimati Actelsar HCT“ i „Upozorenja i mjere opreza“).
The European Medicines Agency has waived the obligation to submit the results of studies with telmisartan hydrochlorothiazide in all subsets of the paediatric population in hypertension (see section 4.2 for information on paediatric use). 
Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja telmisartan hidroklorotiazida u svim podskupinama pedijatrijske populacije u hipertenziji (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
You should also tell your doctor if you experience an increased sensitivity of the skin to the sun with symptoms of sunburn (such as redness, itching, swelling, blistering) occurring more quickly than normal. 
Također morate obavijestiti liječnika ako imate pojačanu osjetljivost kože na sunce sa simptomima opeklina (kao što su crvenilo, svrbež, oticanje, mjehurići) koji se pojavljuju brže nego što je normalno.
Actelsar HCT once daily produces effective and smooth reductions in blood pressure across the therapeutic dose range. 
Actelsar HCT jedanput dnevno dovodi do učinkovitog i ujednačenog sniženja krvnog tlaka u rasponu terapijskih doza.
If hydrochlorothiazide is used during breast-feeding, doses should be kept as low as possible. 
Ako se hidroklorotiazid primjenjuje tijekom dojenja, mora se primijeniti najniža moguća doza.
Conversely, due to the antagonism of the angiotensin II (AT1) receptors by the telmisartan component of Actelsar HCT, hyperkalaemia might occur. 
Nasuprot tome, zahvaljujući antagonizmu receptora angiotenzina II (AT1) putem telmisartanske komponente Actelsara HCT, može doći do pojave hiperkalemije.
The safety and efficacy of Actelsar HCT in children and adolescents aged below 18 have not been established. 
Sigurnost i djelotvornost Actelsara HCT u djece i adolescenata u dobi do 18 godina nisu ustanovljene.
About 60% of the oral dose is eliminated within 48 hours. 
oralne doze se eliminira unutar 48 sati.
Pharmacokinetic studies in patients with hepatic impairment showed an increase in absolute bioavailability up to nearly 100%. 
Farmakokinetičke studije na bolesnicima s oštećenjem funkcije jetre pokazale su povećanje u apsolutnoj bioraspoloživosti do gotovo 100%.
An increase in cholesterol and triglyceride levels has been associated with thiazide diuretic therapy; however, at the 12.5 mg dose contained in Actelsar HCT, minimal or no effects were reported. 
Povećanje razine kolesterola i triglicerida povezano je s tiazidnom diuretskom terapijom; međutim, pri dozi od 12,5 mg koja je sadržana u Actelsaru HCT, zabilježen je minimalan ili nikakav učinak.
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. 
Rizični faktori za razvoj akutnog glaukoma zatvorenog kuta mogu uključivati anamnezu alergije na sulfonamide ili penicilin.
Diarrhoea, dry mouth, flatulence 
Proljev, suha usta, flatulencija
What Actelsar HCT looks like and contents of the pack 
Kako Actelsar HCT izgleda i sadržaj pakiranja
There are no adequate data from the use of Actelsar HCT in pregnant women. 
Ne postoje adekvatni podaci o primjeni Actelsara HCT kod trudnica.
Actelsar HCT may be less effective in lowering the blood pressure in black patients. 
Actelsar HCT može biti manje učinkovit u snižavanju krvnog tlaka kod bolesnika crne rase.
For Al/PVC/PVDC blister: 1 year. 
Za Al/PVC/PVDC blister: 1 godina.
Actelsar HCT is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section). 
Actelsar HCT se ne preporučuje u ranoj trudnoći, te se ne smije uzimati ako ste trudni dulje od 3 mjeseca, jer može izazvati ozbiljna oštećenja bebe ako se primjenjuje u tom stadiju (pogledajte dio o trudnoći).
Rare cases have also been reported with angiotensin II receptor antagonists (including telmisartan/hydrochlorothiazide). 
Rijetki slučajevi također su zabilježeni uz antagoniste receptora angiotenzina II (uključujući telmisartan/hidroklorotiazid).
Elimination Telmisartan: Following either intravenous or oral administration of 14C-labelled telmisartan most of the administered dose (>97%) was eliminated in faeces via biliary excretion. 
Telmisartan: Nakon i intravenske ili peroralne primjene 14C-označenog telmisartana, većina primijenjene doze (>97%) eliminira se fecesom putem bilijarne ekskrecije.
Such conditions should be corrected before the administration of Actelsar HCT. 
Takva stanja moraju se korigirati prije primjene Actelsar HCT.
The absolute bioavailability of telmisartan at 40 mg and 160 mg was 42% and 58%, respectively. 
Apsolutna bioraspoloživost telmisartana pri dozama od 40 mg i 160 mg bila je 42% i 58%, po istom redoslijedu.
Actelsar HCT may increase the blood pressure lowering effect of other medicines used to treat high blood pressure or of medicines with blood pressure lowering potential (e.g. baclofen, amifostine). 
Actelsar HCT može pojačati učinak snižavanja krvnog tlaka drugih lijekova koji se primjenjuju u liječenju visokog krvnog tlaka ili lijekova s potencijalom snižavanja krvnog tlaka (npr. baklofen, amifostin).
Telmisartan is an orally effective and specific angiotensin II receptor subtype 1 (AT1) antagonist. 
Telmisartan je oralno učinkovit i specifičan antagonist podtip 1 receptora angiotenzina II (AT1).
This is confirmed by measurements made at the point of maximum effect and immediately prior to the next dose (through to peak ratios consistently above 80% after doses of 40 and 80 mg of telmisartan in placebo controlled clinical studies). 
Ovo je potvrđeno mjerenjima napravljenima pri maksimalnom učinku i neposredno prije sljedeće doze (omjer između najnižih i vršnih vrijednosti neprekidno iznad 80% nakon doza od 40 i 80 mg telmisartana u placebom kontroliranim kliničkim studijama).
However, the extensive human experience with hydrochlorothiazide has failed to show an association between its use and an increase in neoplasms. 
opsežno iskustvo primjene hidroklorotiazida u ljudi nije pokazalo vezu između njegove primjene i povećanja neoplazmi.
Actelsar HCT is not recommended during pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy. 
Actelsar HCT se ne preporučuje u trudnoći, te se ne smije primjenjivati kada ste trudni dulje od 3 mjeseca, jer može izazvati ozbiljno oštećenje bebe kada se primjenjuje nakon trećeg mjeseca trudnoće.
Influenza-like illness, pain 
Bolest slična gripi, bol
Actelsar HCT is a combination of two active substances, telmisartan and hydrochlorothiazide in one tablet. 
Actelsar HCT je kombinacija dviju djelatnih tvari, telmisartana i hidroklorotiazida, u jednoj tableti.
There is no experience regarding the administration of telmisartan/hydrochlorothiazide in patients with recent kidney transplantation. 
Ne postoji iskustvo glede primjene telmisartana/hidroklorotiazida kod bolesnika s nedavno presađenim bubregom.
In addition, Actelsar HCT should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. 
Nadalje, Actelsar HCT se mora primjenjivati s oprezom kod bolesnika s oštećenom jetrenom funkcijom ili progresivnom bolesti jetre, s obzirom da manje promjene u ravnoteži tekućine i elektrolita mogu precipitirati hepatičku komu.
After a single dose of 14C-labelled telmisartan the glucuronide represents approximately 11% of the measured radioactivity in plasma. 
označenog telmisartana, glukuronid predstavlja oko 11% mjerene radioaktivnosti u plazmi.
Actelsar HCT tablets are for once-daily oral administration and should be taken with liquid, with or without food. 
Actelsar HCT tablete namijenjene su peroralnoj primjeni jednom dnevno, te se moraju uzimati s tekućinom, s ili bez hrane.
Adverse reactions reported in all clinical trials and occurring more frequently (p≤0.05) with telmisartan plus hydrochlorothiazide than with placebo are shown below according to system organ class. 
Nuspojave prijavljene u svim kliničkim ispitivanjima i one koje se češće javljaju (p ≤ 0,05) pri kombinaciji telmisartan plus hidroklorotiazid nego uz placebo prikazane su u nastavku, klasificirane prema organskim sustavima.
The cytochrome P450 isoenzymes are not involved in the metabolism of telmisartan. 
P450 izoenzimi nisu uključeni u metabolizam telmisartana.
Actavis Ltd. BLB016, Bulebel Industrial Estate, Zejtun ZTN 3000, Malta 
BLB016, Bulebel Industrial Estate, Zejtun ZTN 3000, Malta
Insomnia, sleep disorders 
Nesanica, poremećaji spavanja
Pharmacotherapeutic group: Agents acting on the renin-angiotensin system; angiotensin II antagonists and diuretics, ATC code: C09DA07 
Farmakoterapijska skupina: lijekovi koji djeluju na reninsko-angiotenzinski sustav; antagonisti angiotenzina II s diureticima, ATK oznaka: C09DA07
Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of telmisartan hydrochlorothiazide initiation. 
Simptomi uključuju akutan nastup smanjene oštrine vida ili boli u očima, a karakteristično je da se pojavljuju unutar nekoliko sati do tjedana od početka primjene telmisartan hidroklorotiazida.
<1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data). 
<1/10); manje često (≥1/1000 i <1/100); rijetko (≥1/10 000 i <1/1000); vrlo rijetko (<1/10 000); nepoznato (ne može se procijeniti iz dostupnih podataka).
Actelsar HCT should not be given to patients with cholestasis, biliary obstructive disorders or severe hepatic insufficiency (see section 4.3) since telmisartan is mostly eliminated with the bile. 
Actelsar HCT ne smije se davati bolesnicima s kolestazom, bilijarnim opstruktivnim poremećajima ili teškom insuficijencijom jetre (vidjeti dio 4.3), s obzirom da se telmisartan uglavnom eliminira putem žuči.
One study included a population comprised of 71,533 cases of BCC and of 8,629 cases of SCC matched to 1,430,833 and 172,462 population controls, respectively. 
71 533 slučaja BCC-a i 8629 slučajeva SCC-a usklađenih s 1 430 833, odnosno 172 462 kontrola u populaciji.
As with all other angiotensin II receptor antagonists, telmisartan is apparently less effective in lowering blood pressure in black patients than in non blacks, possibly because of higher prevalence of low renin states in the black hypertensive population. 
Etničke razlike Kao i kod svih drugih antagonista receptora angiotenzina II, telmisartan je očigledno manje učinkoviti kod snižavanja krvnog tlaka kod ljudi crne rase nego kod ljudi koji nisu crne rase, vjerojatno zbog veće prevalencije niskih razina renina kod populacije crne rase s hipertenzijom.
- Hydrochlorothiazide belongs to a group of medicines called thiazide diuretics, which cause your urine output to increase, leading to a lowering of your blood pressure. 
- Hidroklorotiazid pripada skupini lijekova koji se nazivaju tiazidski diuretici, koji uzrokuju povećano izlučivanje urina, što također snižava krvni tlak.
The use of Actelsar HCT in children and adolescents up to the age of 18 years is not recommended. 
Primjena Actelsara HCT kod djece i adolescenata ispod 18 godina starosti se ne preporučuje.
If calcium supplements or calcium sparing medicinal products (e.g. vitamin D therapy) must be prescribed, serum calcium levels should be monitored and calcium dose adjusted accordingly. 
Ako se moraju propisati nadomjesci kalcija ili lijekovi koji štede kalcij (npr. terapija vitaminom D), mora se pratiti serumske vrijednosti kalcija te u skladu s time prilagođavati dozu kalcija.
Increased incidence of sepsis has been observed with telmisartan only, however it can not be ruled out for Actelsar HCT. 
Povećana učestalost sepse je primijećena samo uz telmisartan, ali se to ne može isključiti za Actelsar HCT.
No additional preclinical studies have been performed with the Fixed Dose Combination product 80 mg/25 mg. 
Nisu provedene dodatne pretkliničke studije lijekova s kombinacijom fiksnih doza 80 mg/25 mg.
Hydrochlorothiazide: Following oral administration of telmisartan/hydrochlorothiazide, peak concentrations of hydrochlorothiazide are reached in approximately 1.0-3.0 hours after dosing. 
Hidroklorotiazid: Nakon peroralne primjene telmisartana/hidroklorotiazida, vršne koncetracije hidroklorotiazida postižu se za oko 1,0-3,0 sati nakon doziranja.
Contains desiccant, do not eat. 
Sadrži sredstvo za sušenje koje se ne smije pojesti.
- if you have severe liver problems such as cholestasis or biliary obstruction (problems with drainage of the bile from the liver and gall bladder) or any other severe liver disease. 
- ako imate teške jetrene tegobe kao što je kolestaza ili opstrukcija žuči (poteškoće s istjecanjem žuči iz jetre i žučnog mjehura) ili neku drugu tešku bolest jetre.
Although clinically significant hyperkalaemia has not been documented with Actelsar HCT, risk factors for the development of hyperkalaemia include renal insufficiency and/or heart failure, and diabetes mellitus. 
Iako klinički značajna hiperkalemija nije zabilježena uz Actelsar HCT, rizični faktori za razvoj hiperkalemije uključuju renalnu insuficijenciju i/ili zatajenje srca, te šećerna bolest.
Most cases of hepatic function abnormal/liver disorder from post-marketing experience with telmisartan occurred in Japanese patients. 
Većina slučajeva abnormalne jetrene funkcije / poremećaja jetre iz iskustva u razdoblju nakon stavljanja telmisartana u promet pojavila se među japanskom populacijom.
The use of hydrochlorothiazide during breast feeding is not recommended. 
Primjena hidroklorotiazida tijekom dojenja se ne preporučuje.
Actelsar HCT should be taken in patients whose blood pressure is not adequately controlled by telmisartan alone. 
Actelsar HCT namijenjen je bolesnicima čiji se krvni tlak ne može adekvatno kontrolirati samo telmisartanom.
Therefore, it is not expected to potentiate bradykinin-mediated adverse events. 
Stoga se ne očekuje potenciranje nuspojava posredovanih bradikininom.
Adverse reactions known to occur with each component given singly but which have not been seen in clinical trials may occur during treatment with Actelsar HCT. 
Nuspojave za koje se zna da se pojavljuju sa svakom komponentom zasebno, ali nisu bile primijećene u kliničkim ispitivanjima mogu se pojaviti tijekom liječenja
Experience with telmisartan/hydrochlorothiazide is modest in the patients with mild to moderate renal impairment, therefore periodic monitoring of potassium, creatinine and uric acid serum levels is recommended. 
Iskustvo s telmisartanom/hidroklorotiazidom je skromno kod bolesnika s blagim do umjerenim oštećenjem funkcije bubrega, stoga se preporučuje periodično praćenje serumskih vrijednosti kalija, kreatinina i mokraćne kiseline.
The other ingredients are magnesium stearate (E470b), potassium hydroxide, meglumine, povidone, sodium starch glycolate (type A), microcrystalline cellulose, mannitol (E421). 
Drugi sastojci su magnezijev stearat (E470b), kalijev hidroksid, meglumin, povidon, natrijev škroboglikolat (vrste A), mikrokristalična celuloza, manitol (E421).
Thiazides may increase the risk of adverse events caused by amantadine. 
Tiazidi mogu povećati rizik od nuspojava koje uzrokuje amantadin.
- Digoxin. 
.- digoksin.
Al/Al blister, Al/PVC/PVDC blister and HDPE tablet container with LDPE cap and HDPE desiccant with silica filling. 
Al/Al blister, Al/PVC/PVDC blister i HDPE spremnik za tablete sa LDPE zatvaračem i sredstvom za sušenje od silicijevog dioksida u HDPE spremniku.
1 Based on post-marketing experience 2 For further description, please see sub-section “Description of selected adverse reactions” 
1 Na osnovi iskustva u razdoblju nakon stavljanja lijeka u promet 2 Za dodatni opis, molimo pogledajte odlomak „Opis izabranih nuspojava“
Therefore, the use of Actelsar HCT is not recommended. 
Stoga se ne preporučuje primjena Actelsara HCT.
PARTICULARS TO APPEAR ON THE OUTER PACKAGING Carton for Al/PVC/PVDC blister 
PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU Kutija za Al/PVC/PVDC blister
Medicinal products used in the treatment for gout (e.g. probenecid, sulfinpyrazone and allopurinol) Dose adjustment of uricosuric medicinal products may be necessary as hydrochlorothiazide may raise the level of serum uric acid. 
Lijekovi koji se primjenjuju u liječenju gihta (npr. probenecid, sulfinpirazon i alopurinol) Može biti potrebna prilagodba doze urikozuričnih lijekova s obzirom da hidroklorotiazid može povisiti razinu mokraćne kiseline u serumu.
Telmisartan blocks the effect of angiotensin II so that the blood vessels relax, and your blood pressure is lowered. 
Telmisartan blokira učinak angiotenzina II i tako opušta krvne žile te je krvni tlak niži.
Lupus-like syndrome, photosensitivity reactions, skin vasculitis, toxic epidermal necrolysis, erythema multiforme 
Sindrom nalik na lupus, reakcije fotoosjetljivosti, vaskulitis kože, toksična epidermalna nekroliza, multiformni eritem
Anorexia, appetite decreased, electrolyte imbalance, hypercholesterolaemia, hyperglycaemia, hypovolaemia 
Anoreksija, smanjeni apetit, neravnoteža elektrolita, hiperkolesterolemija, hiperglikemija, hipovolemija