natgillin/translations-raw huggingface dataset:
and cobicistat or ritonavir as recommended by your doctor. 
Krka d.d. i ritonavirom, uzimajte prema preporuci Vašeg liječnika.
Darunavir with low dose ritonavir may increase the exposure to grazoprevir. 
Darunavir s niskom dozom ritonavira može povećati izloženost grazopreviru.
Perphenazine, risperidone, thioridazine (to treat psychiatric conditions). 
perfenazin, risperidon, tioridazin (za liječenje psihijatrijskih stanja).
CALCIUM CHANNEL BLOCKERS 
BLOKATORI KALCIJEVIH KANALA Amlodipin
Your doctor will advise you how to deal with your symptoms or whether Darunavir Krka d.d. 
Liječnik će Vam savjetovati što učiniti vezano uz pojavu simptoma i morate li prestati s uzimanjem lijeka Darunavir Krka d.d.
Caution should be used in pregnantwomen with concomitant medications which may further decrease darunavir exposure (see sections 4.5 and 5.2). 
U trudnica je potreban oprez s konkomitantnom terapijom koja može dodatno sniziti izloženost darunaviru (vidjeti dijelove 4.5 i 5.2).
Efavirenz in combination with darunavir may result in sub-optimal darunavir Cmin. 
Efavirenz u kombinaciji s darunavirom može rezultirati suboptimalnom vrijednošću Cmin darunavira.
Take Darunavir Krkad.d.with food. 
- Lijek Darunavir Krka d.d. uzimajte s hranom.
100 milligram ritonavir oral solution: 80 milligram per millilitre 
100 miligrama oralna otopina ritonavira: 80 miligrama po mililitru
can be combined with anti-HIV medicines belonging to another class [e.g. NRTIs (nucleoside reverse transcriptase inhibitors), NNRTIs (non-nucleoside reverse transcriptase inhibitors), CCR5 antagonists and FIs (fusion inhibitors)]. 
NRTI (nukleozidni inhibitori reverzne transkriptaze), NNRTI (ne-nukleozidni inhibitori reverzne transkriptaze), antagonisti receptora CCR5 i IF (inhibitori fuzije)].
is and what it is used for What you need to know before you take Darunavir Krka d.d. 
Što je Darunavir Krka d.d. i za što se koristi Što morate znati prije nego počnete uzimati Darunavir Krka d.d. Kako uzimati Darunavir Krka d.d.
Perphenazine, risperidone, thioridazine (to treat psychiatric conditions) 
- perfenazin, risperidon, tioridazin (za liječenje psihijatrijskih stanja)
HIV ANTIRETROVIRALS Integrase strand transfer inhibitors Dolutegravir dolutegravir AUC ↓ 22% dolutegravir C24h ↓38% dolutegravir Cmax ↓ 11% darunavir ↔* * Using cross-study comparisons to historical pharmacokinetic data 
LIJEKOVI KOJI DJELUJU NA HIV Inhibitori prijenosa lanca integraze Dolutegravir dolutegravir AUC ↓ 22% dolutegravir C24h ↓38% dolutegravir Cmax ↓ 11% darunavir ↔* * Koristeći unakrižnu usporedbu ispitivanja s prethodnim farmakokinetičkim podacima
When used in combination with darunavir co-administered with low dose ritonavir, dose adjustment of indinavir from 800 mg twice daily to 600 mg twice daily may be warranted in case of intolerance. 
Kada se primijeni u kombinaciji s darunavirom istodobno primijenjenim s niskom dozom ritonavira u kombinaciji s indinavirom, može biti potrebna prilagodba doze indinavira s 800 mg dvaput na dan na 600 mg dvaput na dan u slučaju nepodnošljivosti.
Imputations according to the TLOVR algorithm b 
Pripisane vrijednosti izračunate prema TLOVR algoritmu b
The concomitant use with darunavir and low dose ritonavir may require to lower the dose of alfentanil and requires monitoring for risks of prolonged or delayed respiratory depression. 
Istodobna primjena s darunavirom i niskom dozom ritonavira može zahtijevati snižavanje doze alfentanila i zahtijeva praćenje rizika na produljenu ili odgođenu respiratornu depresiju.
Clinical monitoring is recommended when co-administering darunavir with low dose ritonavir with these antidepressants and a dose adjustment of the antidepressant may be needed. 
Preporučuje se kliničko praćanje kada se ti antidepresivi primjenjuju istodobno s pojačanim darunavirom, a može biti potrebna prilagodba doze antidepresiva.
Viruses isolated from patients on darunavir/ritonavir 600/100 mg twice daily experiencing virologic failure by rebound that were susceptible to tipranavir at baseline remained susceptible to tipranavir after treatment in the vast majority of cases. 
Izolirani virusi u bolesnika na darunaviru/ritonaviru od 600/100 mg dvaput na dan u kojih je došlo virološkog neuspjeha zbog ponovnog porasta virusa u krvi, bili su osjetljivi na tipranavir na početku liječenja u velikoj većini su slučajeva ostali osjetljivi na tipranavir i nakon liječenja.
Based on the different elimination pathways of the other NRTIs zidovudine, emtricitabine, stavudine, lamivudine, that are primarily renally excreted, and abacavir for which metabolism is not mediated by CYP450, no interactions are expected for these medicinal compounds and boosted darunavir. 
Lamivudin Stavudin Zidovudin drugih NRTI-ova, zidovudina, emtricitabina, stavudina, lamivudina, koji se primarno izlučuju putem bubrega, te abakavira čiji metabolizam nije posredovan CYP450, ne očekuju se interakcije ovih lijekova i pojačanog darunavira.
Number of subjects with virologic failure and paired baseline/endpoint phenotypes, showing loss of susceptibility to PIs at endpoint compared to baseline, n/N PI darunavir amprenavir atazanavir indinavir lopinavir saquinavir tipranavir 
Broj ispitanika s virološkim neuspjehom a i podaci o fenotipu koji pokazuju rezistenciju na IP na ishodu ispitivanjac, n/N HIV IP darunavir amprenavir atazanavir indinavir lopinavir sakvinavir tipranavir
In all other ART-experienced patients or if HIV-1 genotype testing is not available, the recommended dose regimen is described in the Summary of Product Characteristics for Darunavir Krka d.d. 
- U svih ostalih bolesnika prethodno liječenih ART-om ili u slučaju nemogućnosti genotipizacije HIV-1, preporučeni režim doziranja opisan je u sažetku opisa svojstava lijeka za Darunavir Krka d.d. 600 mg tablete.
ART-experienced paediatric patients from the age of 3 to < 6 years The pharmacokinetics, safety, tolerability and efficacy of darunavir/ritonavir twice daily in combination with other antiretroviral agents in 21 ART-experienced HIV-1 infected paediatric patients aged 3 to < 6 years and weighing 10 kg to < 20 kg was evaluated in an open-label, Phase II trial, ARIEL. 
Pedijatrijski bolesnici prethodno liječeni ART-om u dobi od 3 do 6 godina Farmakokinetika, sigurnost, podnošljivost i djelotovornost darunavira/ritonavira dvaput na dan u kombinaciji s drugim antiretrovirusnim lijekovima, procijenjene su u otvorenom ispitivanju ARIEL faze II, u 21 pedijatrijskog bolesnika prethodno liječenih ART-om inficiranih s HIV-1, u dobi od 3 do < 6 godina i težine 10 kg do < 20 kg.
Instructions for children 3 years of age and above, weighing more than 40 kilograms Take 800 milligram Darunavir Krka d.d. 
Upute za djecu od 3 godine i više, težine najmanje 40 kilograma - Uzmite 800 miligrama lijeka Darunavir Krka d.d. (2 tablete koja sadrže
The pharmacokinetic enhancing effect of cobicistat on darunavir was evaluated in a Phase I study in healthy subjects that were administered darunavir 800 mg with either cobicistat at 150 mg or ritonavir at 100 mg once daily. 
Učinak farmakokinetičkog pojačivača kobicistata na darunavir bio je procijenjen u ispitivanju faze I u zdravih dobrovoljaca kojima je darunavir od 800 mg bio primijenjen bilo s kobicistatom od 150 mg ili ritonavirom od 100 mg jedanput na dan.
Lopinavir/ ritonavir 800/200 mg per day N=346 
lopinavir/ ritonavir 800/200 mg na dan N=346
Take your other HIV medicines used in combination with Darunavir Krkad.d.and ritonavir as recommended by your doctor. 
- Ostale lijekove protiv HIV-a koje primjenjujete istodobno s lijekom Darunavir Krka d.d. i kobicistatom ili ritonavirom uzimajte prema preporuci Vašeg liječnika.
This dose must not exceed the recommended adult dose, which is 800 milligram Darunavir Krka d.d. 
Ova doza ne smije prekoračiti preporučenu dozu za odrasle, što je 800 miligrama lijeka Darunavir Krka d.d. zajedno sa 100 miligrama ritonavira jedanput na dan.
Your doctor may evaluate how severe your liver disease is before deciding if you can take Darunavir Krka d.d.. 
Liječnik može procijeniti koliko je teška Vaša bolest jetre prije nego što odluči možete li uzimati lijek Darunavir Krka d.d. - Upozorite liječnika ako imate šećernu bolest.
is used to treat adults and children of 3 years of age and above, and at least 15 kilogram body weight who are infected by HIV and who have already used other antiretroviral medicines. 
Darunavir Krka d.d. se koristi za liječenje odraslih i djece u dobi od 3 godine i starije, tjelesne težine najmanje 15 kilograma, koji su zaraženi HIV-om te su prethodno koristili druge antiretrovirusne lijekove.
Darunavir/ritonavir N=80 
Ishodi u 48. tjednu darunavir/ritonavir N=80
Monitoring of renal function may be indicated when darunavir coadministered with low dose ritonavir is given in combination with tenofovir disoproxil, particularly in patients with underlying systemic or renal disease, or in patients taking nephrotoxic agents. 
Praćenje funkcije bubrega može biti indicirano kada se darunavir istodobno primijenjen s niskom dozom ritonavira daje u kombinaciji s tenofovir dizoproksilomom, posebno u bolesnika s podležećom sistemskom ili bubrežnom bolešću ili u bolesnika koji uzimaju nefrotoksične lijekove.
(CYP3A and OATP1B inhibition) 
(CYP3A i OATP1B inhibicija) kontraindicirana (vidjeti dio 4.3).
cannot work properly without ritonavir. 
Darunavir Krka d.d. ne može pravilno djelovati bez ritonavira.
once daily. 
Doziranje jedanput na dan
- The other ingredients are cellulose, microcrystalline; crospovidone, hydroxypropylcellulose; silica, colloidal anhydrous; silicified microcrystalline cellulose (cellulose, microcrystalline; silica, colloidal anhydrous) and magnesium stearate (E470b) in the tablet core and poly(vinyl alcohol), macrogol, titanium dioxide (E171), talc (E553b), yellow iron oxide (E172) and red iron oxide (E172) in film coating. 
- Drugi sastojci su mikrokristalična celuloza, krospovidon, hidroksipropilceluloza, koloidni bezvodni silicijev dioksid, silicificirana mikrokristalična celuloza (mikrokristalična celuloza, koloidni bezvodni silicijev dioksid) i magnezijev stearat (E470b) u jezgri tablete te poli(vinilni alkohol), makrogol, titanijev dioksid (E171), talk (E553b), žuti željezov oksid (E172) i crveni željezov oksid (E172) u film ovojnici tablete.
Sildenafil Tadalafil Vardenafil sildenafil alone and a single intake of 25 mg sildenafil co-administered with darunavir and low dose ritonavir. 
Tadalafil Vardenafil unosom jednokratne doze od 100 mg samo sildenafila i unosa jednokratne doze od 25 mg sildenafila istodobno primijenjenog s darunavirom i niskom dozom ritonavira.
Talc (E553b) Iron oxide, yellow (E172) Iron oxide, red (E172) 
poli(vinilni alkohol) makrogol titanijev dioksid (E171) talk (E553b) željezov oksid, žuti (E172) željezov oksid, crveni (E172)
The following patient populations were evaluated (see section 5.1): 80 ART-experienced HIV-1 infected paediatric patients aged from 6 to 17 years and weighing at least 20 kg who received darunavir tablets with low dose ritonavir twice daily in combination with other antiretroviral agents. 
U nastavku je navedena populacija bolesnika koja je bila procijenjena (vidjeti dio 5.1): - 80 pedijatrijskih bolesnika u dobi od 6 do 17 godina i težine najmanje 20kg, prethodno liječenih ART-om, a inficirani su virusom HIV-1 te su primali darunavir tablete s niskom dozom ritonavira dvaput na dan u kombinaciji s drugim antiretrovirusnim lijekovima.
If you forget to take Darunavir Krka d.d. 
Ako ste zaboravili uzeti lijek Darunavir Krka d.d.
Darunavirgiven with low dose ritonavir may be considered as an alternative. 
Darunavir koji se daje s niskom dozom ritonavira može se uzeti u obzir kao zamjena.
300 mg once daily atazanavir AUC ↔ atazanavir Cmin ↑ 52% atazanavir Cmax ↓ 11% darunavir AUC ↔ 
300 mg jedanput na dan atazanavir AUC ↔ atazanavir Cmin ↑ 52% atazanavir Cmax ↓ 11%
Concentrations of these medicinal products may be increased when coadministered with darunavir with low dose ritonavir resulting in the potential for increased adverse events usually associated with these agents. 
Koncentracije tih lijekova mogu se povećati kada se primjenjuju istodobno s darunavirom s niskom dozom ritonavira rezultirajući potencijalom za povećanje nuspojava obično povezanih s tim lijekovima.
Concomitant administration of boosted darunavir and quetiapine is contraindicated as it may increase quetiapine-related toxicity. 
darunavira i kvetiapina je kontraindicirana jer može povisiti toksičnost povezanu s kvetiapinom.
Atorvastatin 10 mg once daily atorvastatin AUC ↑ 3-4 fold atorvastatin Cmin ↑ ≈5.5-10 fold atorvastatin Cmax ↑ ≈2 fold darunavir/ritonavir 
Atorvastatin 10 mg jedanput na dan atorvastatin AUC ↑ 3-4 puta atorvastatin Cmin ↑ ≈5.5-10 puta
Amitriptyline Desipramine Imipramine Nortriptyline Trazodone paroxetine AUC ↓ 39% paroxetine Cmin ↓ 37% paroxetine Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertraline AUC ↓ 49% sertraline Cmin ↓ 49% sertraline Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔ 
Amitriptilin Dezipramin Imipramin Nortriptilin Trazodon paroksetin AUC ↓ 39% paroksetin Cmin ↓ 37% paroksetin Cmax ↓ 36% darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔ sertralin AUC ↓ 49% sertralin Cmin ↓ 49% sertralin Cmax ↓ 44% darunavir AUC ↔ darunavir Cmin ↓ 6% darunavir Cmax ↔
150 mg twice daily maraviroc AUC ↑ 305% maraviroc Cmin ND maraviroc Cmax ↑ 129% darunavir, ritonavir concentrations were 
150 mg dvaput na dan maravirok AUC ↑ 305% maravirok Cmin ND maravirok Cmax ↑ 129% koncentracije darunavira, ritonavira bile su sukladne s
Concomitant use of other PDE-5 inhibitors for the treatment of erectile dysfunction with darunavir coadministered with low dose ritonavir should be done with caution. 
Mora se s oprezom istodobno primjenjivati druge inhibitore PDE-5 za liječenje erektilne disfunkcije s darunavirom primijenjenog istodobno s niskom dozom ritonavira.
-The other ingredients arecellulose,microcrystalline;crospovidone, hydroxypropylcellulose; silica, colloidal anhydrous; silicified microcrystalline cellulose(cellulose,microcrystalline; silica, colloidal anhydrous)and magnesium stearate (E470b)in the tablet core and poly(vinyl alcohol), macrogol, titanium dioxide (E171), talc (E553b), yellow iron oxide (E172) -only for 400mgfilm-coated tablets and red iron oxide (E172)in film coating. 
- Drugi sastojci su mikrokristalična celuloza, krospovidon, hidroksipropilceluloza, koloidni bezvodni silicijev dioksid, silicificirana mikrokristalična celuloza (mikrokristalična celuloza, koloidni bezvodni silicijev dioksid) i magnezijev stearat (E470b) u jezgri tablete te poli(vinilni alkohol), makrogol, titanijev dioksid (E171), talk (E553b), žuti željezov oksid (E172)samo za 400 mg filmom obložene tablete i crveni željezov oksid (E172) u film ovojnici tablete.
≥ 30 kg-< 40 kg 675 mg darunavir/100 mg ritonavir once daily 
≥ 30 kg-< 40 kg 675 mg darunavir /100 mg ritonavir jedanput na dan
see section 4.5) sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil simvastatin, lovastatin and lomitapide (see section 4.5) dabigatran, ticagrelor (see section 4.5). 
avanafil - simvastatin, lovastatin i lomitapid (vidjeti dio 4.5) - dabigatran, tikagrelor (vidjeti dio 4.5).
Co-administration of darunavir and ritonavir and other medicinal products that inhibit CYP3A may decrease the clearance of darunavir and ritonavir and may result in increased plasma concentrations of darunavir and ritonavir (e.g. indinavir azole antifungals like clotrimazole). 
Istodobna primjena darunavira i ritonavira i drugih lijekova koji inhibiraju CYP3A može smanjiti klirens darunavira i ritonavira te može rezultirati povišenjem koncentracija darunavira i ritonavira u plazmi (npr. indinavir, antifungalni azoli poput klotrimazola).
400 and 800 milligram tablets are used to treat adults and children (3 years of age and above, at least 40 kilograms body weight) who are infected by HIV and who have not used antiretroviral medicines before. 
Tablete lijeka Darunavir Krka d.d. od 400 miligrama i 800 miligrama koriste se za liječenje odraslih i djece (u dobi od 3 godine i starije, tjelesne težine najmanje 40 kilograma) koji su zaraženi HIV-om i - prethodno nisu uzimali antiretrovirusne lijekove. - u pojedinih bolesnika koji su već prije koristili antiretrovirusne lijekove (to će ustanoviti Vaš liječnik).
that the lowest possible dose of digoxin should initially be prescribed in case digoxin is given to patients on darunavir/ritonavir therapy. 
Budući da digoksin ima uzak terapijski indeks, preporučuje se inicijalno propisati najnižu moguću dozu digoksina u slučaju kada se digoksin daje bolesnicima koji su na terapiji darunavirom/ritonavirom.
Darunavir/ritonavir N=12 
Ishodi u 48. tjednu darunavir/ritonavir N=12
with ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs. 
Darunavir Krka d.d. s ritonavirom nije bio ispitan sa svim IP (inhibitori proteaze) i ne smije se uzimati s drugim IP HIV-a.
800 mg film-coated tablets are available in bottles containing 30 film-coated tablets (1 bottle of 30 film-coated tablets) and 90 film-coated tablets (3 bottles of 30 film-coated tablets) in a box. 
Darunavir Krka d.d. 800 mg filmom obložene tablete dostupne su u bočicama koje sadrže 30 filmom obloženih tableta (1 bočica s 30 filmom obloženih tableta) i 90 filmom obloženih tableta (3 bočice s 30 filmom obloženih tableta) u kutiji.
may still develop infections or other illnesses associated with HIV infection. 
Osobe koje uzimaju Darunavir Krka d.d. i dalje mogu razvijati infekcije ili druge bolesti povezane s HIV infekcijom.
In the morning, take one 600 milligram Darunavir Krkad.d.tablettogether with 100 milligram ritonavir. 
- Ujutro uzmite jednu tabletu lijeka Darunavir Krka d.d. od 600 miligrama zajedno sa 100 miligrama ritonavira.
A reduction in colchicine dosage or an interruption of colchicine treatment is recommended in patients with normal renal or hepatic function 
Ako je potrebno liječenje pojačanim darunavirom, preporučuje se smanjiti dozu kolhicina ili prekinuti liječenje kolhicinom u bolesnika s normalnom funkcijom bubrega ili jetre.
Darunavir Krka d.d., co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection. 
Darunavir Krka d.d., primijenjen istodobno s niskom dozom ritonavira, indiciran je u kombinaciji s drugim antiretrovirusnim lijekovima za liječenje bolesnika koji su inficirani virusom humane imunodeficijencije (HIV-1).
#, a comparable systemic exposure to sildenafil was observed for a single intake of 100 mg sildenafil alone and a single intake of 25 mg sildenafil co-administered with darunavir and low dose ritonavir. 
U ispitivanju interakcija primijećena je usporediva sistemska izloženost sildenafilu unosom jednokratne doze od 100 mg samo sildenafila i unosa jednokratne doze od 25 mg sildenafila istodobno primijenjenog s darunavirom i niskom dozom ritonavira.
Clinical monitoring is recommended when co-administering darunavir with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered. 
pojačan darunavir s tim sedativima/hipnoticima i u obzir treba uzeti nižu dozu sedativa/hipnotika.
every day and always in combination with 150 milligram of cobicistat or 100 milligram of ritonavir and with food. 
Lijek Darunavir Krka d.d. morate uzimati svaki dan i uvijek u kombinaciji sa 150 mg kobicistata ili 100 miligrama ritonavira i s hranom.
with cobicistat or ritonavir has not been tested with all PIs (protease inhibitors) and must not be used with other HIV PIs. 
Darunavir Krka d.d. s kobicistatom ili ritonavirom nije bio ispitan sa svim IP (inhibitori proteaze) i ne smije se uzimati s drugim IP HIV-a.
The dosage of other medicines might need to be changed since either their own or Darunavir Krka d.d. 
Postoji mogućnost da će biti potrebno promijeniti doziranje drugih lijekova, s obzirom na mogućnost promjene terapijskog učinka ili nuspojava tih lijekova ili lijeka Darunavir Krka d.d. kada se primjenjuju u kombinaciji.
Skin and subcutaneous tissue disorders common rash (including macular, maculopapular, papular, erythematous and pruritic rash), pruritus uncommon angioedema, generalised rash, allergic dermatitis, urticaria, eczema, erythema, hyperhidrosis, night sweats, alopecia, acne, dry skin, nail pigmentation rare 
Poremećaji kože i potkožnog tkiva često osip (uključujući makularni, makulopapularni, papularni, eritematozni i osip koji svrbi), pruritus manje često angioedem, generalizirani osip, alergijski dermatitis, urtikarija, ekcem, eritem, hiperhidroza, noćna znojenja, alopecija, akne, suha koža, pigmentacija noktiju
Each film-coated tablet contains 400mg or 800mg darunavir. 
Jedna filmom obložena tableta sadrži 400 mg ili 800 mg darunavira.
Based on theoretical considerations darunavir is expected to increase alfuzosin plasma concentrations. 
Temeljeno na teorijskim postavkama očekuje se da će darunavir povećati koncentracije alfuzozina u plazmi. (CYP3A inhibicija)
In the evening, take one 600 milligram Darunavir Krkad.d.tablettogether with 100 milligram ritonavir. 
- Navečer uzmite jednu tabletu lijeka Darunavir Krka d.d. od 600 miligrama zajedno sa 100 miligrama ritonavira.
Caution should be exercised when combining one of these antineoplastic agents with darunavir with low dose ritonavir. 
Potreban je oprez kada se neki od tih antineoplastika kombinira s darunavirom primijenjenim s niskom dozom ritonavira.
Skin and subcutaneous tissue disorders very common rash (including macular, maculopapular, papular, erythematous, pruritic rash, generalised rash, and allergic dermatitis) 
Nuspojava vrlo često osip (uključujući makularni, makulopapularni, papularni, eritematozni, pruritički osip, generalizirani osip i alergijski dermatitis)
The doctor will inform you on how many Darunavir Krka d.d. 
Liječnik će Vas informirati koliko Darunavir Krka d.d. tableta dijete mora uzeti.
800 milligram Darunavir Krka d.d. 
Darunavir Krka d.d. 800 mg
works by reducing the amount of HIV in your body. 
Darunavir Krka d.d. djeluje tako da smanjuje količinu virusa HIV-a u Vašem tijelu.
When administration of atorvastatin and darunavir co-administered with low dose ritonavir is desired, it is recommended to start with an atorvastatin dose of 10 mg once daily. 
Kada se želi primijeniti atorvastatin i darunavir atorvastatin Cmax ↑ ≈2 puta darunavir/ritonavir primijenjen istodobno s niskom dozom ritonavira, preporučuje se početi s dozom atorvastatina od 10 mg jedanput na dan.
Darunavir Krka d.d., co-administered with cobicistat is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection in adult patients (see section 4.2). 
Darunavir Krka d.d., primijenjen istodobno s kobicistatom, indiciran je u kombinaciji s drugim antiretrovirusnim lijekovima za liječenje infekcije virusom humane imunodeficijencije (HIV-1) u odraslih bolesnika (vidjeti dio 4.2).
The use of darunavir co-administered with low dose ritonavir and these anticoagulants is not recommended. 
primjena primjena darunavira istodobno primijenjenog s niskom dozom ritonavira i ovih antikoagulansa.
Darunavir Krka d.d., co-administered with low dose ritonavir is indicated in combination with other antiretroviral medicinal products for the treatment of patients with human immunodeficiency virus (HIV-1) infection (see section 4.2). 
Darunavir Krka d.d., primijenjen istodobno s niskom dozom ritonavira, indiciran je u kombinaciji s drugim antiretrovirusnim lijekovima za liječenje bolesnika koji su inficirani virusom humane imunodeficijencije (HIV-1) (vidjeti dio 4.2).
600 mg darunavir/100 mg ritonavir twice daily ritonavir oral solution: 80 mg/ml 
600 mg darunavir /100 mg ritonavir dvaput na dan oralna otopina ritonavira: 80 mg/ml
Ethinylestradiol Norethindrone 35 μg/1 mg once daily drospirenone AUC ↑ 58% drospirenone Cmin ND drospirenone Cmax ↑ 15% 
Etinilestradiol drospirenon AUC ↑ 58% drospirenon Cmin NO drospirenon Cmax ↑ 15%
30 film-coated tablets: EU/1/17/1248/009 90 film-coated tablets: EU/1/17/1248/010 
30 filmom obloženih tableta: EU/1/17/1248/009 90 filmom obloženih tableta: EU/1/17/1248/010