natgillin/translations-raw huggingface dataset:
Parasite resistance to any particular class of parasiticides may develop following the frequent, repeated use of a product of that class. 
Paraziti mogu razviti rezistenciju na određenu skupinu paraziticida u slučaju učestale i višekratne upotrebe proizvoda iz te klase.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients. 
Ne primjenjivati u slučajevima preosjetljivosti na djelatne tvari ili neku od pomoćnih tvari.
− For the treatment of flea infestations (Ctenocephalides felis and Ctenocephalides canis). 
Za liječenje infestacije buhama (Ctenocephalides felis i Ctenocephalides canis).
Simparica Trio tablets are palatable and readily consumed by the majority of dogs when offered by the owner. 
Trio tablete su ugodnog okusa i većina pasa ih bez oklijevanja uzima od vlasnika.
The veterinary medicinal product should be administered at a dose of 1.2-2.4 mg/kg of sarolaner, 0.024-0.048 mg/kg of moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table: 
Veterinarsko-medicinski proizvod potrebno je primijeniti u dozi od 1,2-2,4 mg/kg sarolanera, 0,0240,048 mg/kg moksidektina i 5-10 mg/kg pirantela, prema sljedećoj tablici:
In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistanceprotein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. 
U laboratorijskim istraživanjima, proizvod je imao dobru podnošljivost u pasa s nedostatkom proteina-1 (MDR-1 -/-), nakon jedne oralne primjene 3 puta veće doze od preporučene.
The primary target of action of sarolaner in insects and acarines is functional blockade of ligand-gated chloride channels (GABA-receptors and glutamate-receptors). 
Primarni cilj djelovanja sarolanera na insekte i akaricide je funkcionalna blokada ligandom reguliranih kloridnih kanala (GABA receptori i receptori glutamata).
Sarolaner is readily and rapidly absorbed systemically following oral dosing, reaching maximum concentrations in plasma within 3.5 hours (tmax) after administration with a high bioavailability of 86.7%. 
Sarolaner se lako i brzo sustavno apsorbira nakon oralne primjene te postiže maksimalne koncentracije u plazmi unutar 3,5 sati (tmax) nakon primjene, uz visoku bioraspoloživost od 86,7%.
Pyrantel mimics the agonist effects of ACh through high affinity binding to subtype specific ionophoric nAChRs in nematodes, while not binding at muscarinic mAChRs. 
Pirantel oponaša agonističke učinke ACh-a tako što se s visokim afinitetom veže na podtip specifičnih ionofornih nAChR-a kod nematoda, ali se ne veže na muskarinske mAChR-e.
Ticks and fleas need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious parasite-borne diseases cannot be excluded. 
Da bi postali izloženi sarolaneru, krpelji i buhe moraju se početi hraniti krvlju domaćina, stoga se ne može isključiti prijenos infektivnih bolesti koje paraziti prenose.
The veterinary medicinal product also provides concurrent efficacy for the prevention of heartworm disease and angiostrongylosis. 
Ovaj veterinarsko-medicinski proizvod također pruža istovremenu učinkovitost za prevenciju bolesti srčanog crva i angiostrongiloze.
Pyrantel is active against immature stages (L5) and adults of Toxocara canis, adults of Ancylostoma caninum, Toxascaris leonina and Uncinaria stenocephala. 
Pirantel djeluje protiv nezrelih stadija (L5) i odraslih Toxocara canis, odraslih Ancylostoma caninum, Toxascaris leonina i Uncinaria stenocephala.
The veterinary medicinal product can be used as part of the seasonal treatment of fleas and ticks (replacing treatment with a mono-active flea and tick product) in dogs with diagnosed concurrent gastrointestinal nematode infections. 
Veterinarsko-medicinski proizvod može se koristiti kao dio sezonskog tretiranja buha i krpelja (kao zamjena za tretiranje proizvodima protiv buha i krpelja s jednom djelatnom tvari) u pasa s dijagnosticiranim istodobnim infestacijama gastrointestinalnim nematodima.
Moxidectin is readily and rapidly absorbed systemically following oral dosing, reaching maximum concentrations in plasma within 2.4 hours (tmax) after administration and with 66.9% bioavailability. 
Moksidektin se lako i brzo sustavno apsorbira nakon oralne primjene te postiže maksimalne koncentracije u plazmi unutar 2,4 sati (tmax) nakon primjene, uz bioraspoloživost od 66,9%.
moxidectin (mg) 
moksidektin (mg)
Sarolaner is slowly eliminated from plasma (half-life of approximately 12 days) via biliary excretion and elimination through the faeces with minor contributions of metabolic clearance. 
Sarolaner se sporo eliminira iz plazme (poluvijek od približno 12 sati) putem bilijarnog izlučivanja i eliminacije kroz feces, uz manje doprinose metaboličkog klirensa.
The product should only be used in dogs when treatment of ticks / fleas and gastrointestinal nematodes is indicated at the same time. 
Proizvod je potrebno primjenjivati u pasa samo kada je istovremeno indicirano liječenje krpelja/buha i gastrointestinalnih nematoda.
Sarolaner binding to these receptors prevents the uptake of chloride ions by GABA and glutamate gated ion channels, thus resulting in increased nerve stimulation and death of the target parasite. 
Sarolaner koji se veže na ove receptore sprečava pohranu kloridnih iona putem ionskih kanala reguliranih GABA-om i glutamatom, što rezultira povećanom stimulacijom živaca i smrću ciljniog parazita.
Moxidectin is slowly eliminated from plasma (half-life of approximately 11 days) via biliary excretion and elimination through the faeces with minor contributions of metabolic clearance. 
Moksidektin se sporo eliminira iz plazme (poluvijek od približno 11 dana) putem bilijarnog izlučivanja i eliminacije kroz feces, uz manje doprinose metaboličkog klirensa.
Its principal mode of action is interfering with neuromuscular transmission at the level of the glutamate-gated chloride channels and, to a lesser extent, of GABA (gamma amino butyric acid)-gated channels. 
Njegov glavni način djelovanja je ometanje neuromuskularnog prijenosa na razini glutamatom reguliranih kloridnih kanala te, u manjoj mjeri, GABA-om (gama-aminomaslačna kiselina) reguliranih kanala.
Prevention of heartworm disease and angiostrongylosis: 
Prevencija bolesti srčanog crva i angiostrongiloze:
Sarolaner blocks GABA- and glutamate-gated chloride channels in the central nervous system of insects and acarines. 
Sarolaner blokira GABA-om i glutamatom regulirane kloridne kanale u središnjem živčanom sustavu insekata i akarina.
− For the treatment of tick infestations. 
Za liječenje infestacija krpeljima.
The veterinary medicinal product is exclusively indicated when use against ticks or fleas and gastrointestinal nematodes is indicated at the same time. 
Ovaj veterinarsko-medicinski proizvod indiciran je isključivo kada je istovremeno indicirana primjena protiv krpelja ili buha i gastrointestinalnih nematoda.
− For the prevention of angiostrongylosis by reducing the level of infection with immature adult 
Za prevenciju angiostrongiloze smanjenjem razine infekcije nezrelim adultnim (L5) stadijima
Treatment of flea and tick infestations and gastrointestinal nematodes: 
Liječenje infestacija buhama i krpeljima i gastrointestinalnim nematodima:
3 mg/0.06 mg/12.5 mg 6 mg/0.12 mg/25 mg 12 mg/0.24 mg/50 mg 24 mg/0.48 mg/100 mg 48 mg/0.96 mg/200 mg 72 mg/1.44 mg/300 mg sarolaner/moxidectin/pyrantel (EN or Latin) 
3 mg/0,06 mg/12,5 mg 6 mg/0,12 mg/25 mg 12 mg/0,24 mg/50 mg 24 mg/0,48 mg/100 mg 48 mg/0,96 mg/200 mg 72 mg/1,44 mg/300 mg sarolaner/moksidektin/pirantel (EN ili Latinski)
The veterinary medicinal product has immediate and persistent tick killing activity for 5 weeks against Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus and for 4 weeks against Dermacentor reticulatus; 
Veterinarsko-medicinski proizvod ima trenutačan i postojan učinak ubijanja krpelja tijekom 5 tjedana protiv Ixodes hexagonus, Ixodes ricinus i
sarolaner 3 mg/moxidectin 0.06 mg/pyrantel (as embonate) 12.5 mg sarolaner 6 mg/moxidectin 0.12 mg/pyrantel (as embonate) 25 mg sarolaner 12 mg/moxidectin 0.24 mg/pyrantel (as embonate) 50 mg sarolaner 24 mg/moxidectin 0.48 mg/pyrantel (as embonate) 100 mg sarolaner 48 mg/moxidectin 0.96 mg/pyrantel (as embonate) 200 mg sarolaner 72 mg/moxidectin 1.44 mg/pyrantel (as embonate) 300 mg 
sarolaner 3 mg/moksidektin 0,06 mg/pirantel (kao embonat) 12,5 mg sarolaner 6 mg/moksidektin 0,12 mg/pirantel (kao embonat) 25 mg sarolaner 12 mg/moksidektin 0,24 mg/pirantel (kao embonat) 50 mg sarolaner 24 mg/moksidektin 0,48 mg/pirantel (kao embonat) 100 mg sarolaner 48 mg/moksidektin 0,96 mg/pirantel (kao embonat) 200 mg sarolaner 72 mg/moksidektin 1,44 mg/pirantel (kao embonat) 300 mg
Fleas on the animal prior to administration are killed within 8 hours. 
Buhe na životinji prisutne prije primjene ugibaju u roku od 8 sati.
Calcium hydrogen phosphate anhydrous 
Kalcijev hidrogenfosfat, bezvodni
− Toxocara canis immature adults (L5) and adults; 
− nezreli odrasli oblici (L5) i adulti Toxocara canis;
(L5) stages of Angiostrongylus vasorum. 
L4 stadija Dirofilaria immitis i nezrelih stadija (L5) Angiostrongylus vasorum.
Simparica Trio 1.25-2.5 kg Simparica Trio >2.5-5 kg Simparica Trio >5-10 kg Simparica Trio >10-20 kg Simparica Trio >20-40 kg Simparica Trio >40-60 kg 
Simparica Trio >2,5-5 kg Simparica Trio >5-10 kg Simparica Trio >10-20 kg Simparica Trio >20-40 kg Simparica Trio >40-60 kg
Tablet strength 72 mg/1.44 mg/300 mg 
72 mg/1,44 mg/300 mg
Wheat germ 
Pšenične klice
Hydrolysed vegetable protein Gelatin 
Svinjska jetra u prahu Hidrolizirani biljni protein Želatina
For the treatment of gastrointestinal roundworm and hookworm infections: 
Za liječenje gastrointestinalnih infekcija oblićima i kukastim crvima:
Other nematodes 
Drugi nematodi
Confectioner's sugar Glucose, liquid 
Glukoza, tekuća
Each tablet contains: 
KVALITATIVNI I KVANTITATIVNI SASTAV Jedna tableta sadrži:
Tablet strength 48 mg/0.96 mg/200 mg 
48 mg/0,96 mg/200 mg
Butylhydroxytoluene (E321) Pigment blend 018 (E110, E129, E132) Hydroxypropylcellulose Silica, colloidal anhydrous Magnesium stearate Maize starch 
Butilhidroksitoluen (E321) Mješavina pigmenta 018 (E110, E129, E132)
Tablet strength 24 mg/0.48 mg/100 mg 
24 mg/0,48 mg/100 mg
Ectoparasites 
Simparica
− Ancylostoma caninum L4 larvae, immature adults (L5) and adults; 
− L4 larve, nezreli odrasli oblici (L5) i adulti Ancylostoma caninum;
Pork liver powder 
Šećer u prahu
for dogs 1.25-2.5 kg for dogs >2.5-5 kg for dogs >5-10 kg for dogs >10-20 kg for dogs >20-40 kg for dogs >40-60 kg 
za pse 1,25-2,5 kg za pse >2,5-5 kg za pse >5-10 kg za pse >10-20 kg za pse >20-40 kg za pse >40-60 kg
Sarolaner is active against adult fleas (Ctenocephalides felis and Ctenocephalides canis) as well as several tick species such as Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus. 
Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus i Rhipicephalus sanguineus.
Tablet strength 3 mg/0.06 mg/ 12.5 mg 
Jačina tablete 3 mg/0,06 m g/12,5 mg
Moxidectin is active against adults of Toxocara canis, L4 larvae and immature stages (L5) of Ancylostoma caninum, L4 of Dirofilaria immitis and immature stages (L5) of Angiostrongylus vasorum. 
Moksidektin djeluje protiv odraslih jedinki Toxocara canis, L4 larvi i nezrelih stadija (L5)
chewable tablet 
OBLIK tableta za žvakanje
Lactose monohydrate Sodium starch glycolate type A Meglumine 
Natrijev škrobni glikolat tipa
Tablet strength 12 mg/0.24 mg/50 mg 
12 mg/0,24 mg/50 mg
Tablet strength 6 mg/0.12 mg/25 mg 
Jačina tablete 6 mg/0,12 m g/25 mg
Tablet strength 3 mg/0.06 mg/12.5 mg 
3 mg/0,06 m g/12,5 mg
Manufacturer responsible for batch release: Corden Pharma GmbH Otto-Hahn-Str., Plankstadt 68723 Baden-Wuerttemberg GERMANY 
68723 Baden-Wuerttemberg
PACKAGE LEAFLET: Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg Simparica Trio chewable tablets for dogs >5-10 kg Simparica Trio chewable tablets for dogs >10-20 kg Simparica Trio chewable tablets for dogs >20-40 kg Simparica Trio chewable tablets for dogs >40-60 kg 
UPUTA O VMP ZA: Simparica Trio tablete za žvakanje za pse od 1,25-2,5 kg Simparica
Use at the same time each day. 
Primijenite svaki dan u isto vrijeme.
Tilt your head back. 
Zabacite glavu prema natrag.
Carton containing 1 or 3 bottles. 
Kutija sadrži 1 ili 3 boce.
Plasma concentrations are very low. 
Koncentracije u plazmi su vrlo niske.
All subjects were reported to have made a full recovery, usually within 6-24 hours. 
Kod svih bolesnika došlo je do potpunog oporavka, obično unutar 6-24 sata.
Continue with the next dose as planned. 
Nastavite sa slijedećom dozom kako je planirano.
There are no efficacy and safety data for adjunct therapy beyond 6 weeks. 
Nema podataka o djelotvornosti i sigurnosti dodatne terapije nakon 6 tjedana.
Do not touch the dropper with your fingers when opening or closing the bottle. 
Ne dodirujte kapaljku sa prstima kada otvarate ili zatvarate bocu.
Contact with soft contact lenses should be avoided. 
Kontakt s mekim kontaktnim lećama se mora izbjegavati.
Date of first authorisation: 18 July 2014 Date of last renewal: 20 February 2019 
Datum posljednje obnove odobrenja: 20. veljače 2019.
Hold the bottle, pointing down, between your thumb and fingers. 
Držite bocu, okrenutu prema dolje, između palca i ostalih prstiju.
The safety and efficacy of SIMBRINZA in children and adolescents aged 2 to 17 years have not been established. 
Sigurnost i djelotvornost SIMBRINZE u djece i adolescenata u dobi od 2 do 17 godina nisu ustanovljene.
Wash your hands before you start. 
Operite ruke prije primjene.
Do not put in any more drops until it is time for your next regular dose. 
Ne ukapavajte dalje kapi sve dok ne dođe vrijeme za slijedeću uobičajenu dozu.
The drop will go in here (picture 1). 
. Tu se nanosi kap (slika 1).
If you use drops in both eyes, repeat the steps for your other eye. 
Ako primjenjujete kapi na oba oka, ponovite korake za dugo oko.
Do not drive or use machines until the symptoms are cleared. 
Nemojte upravljati vozilima ni strojevima sve dok Vam se ovi simptomi ne povuku.
Only use SIMBRINZA for your eyes. 
SIMBRINZU primjenjujte samo za oči.
BE-2870 Puurs Belgium or 
BE-2870 Puurs Belgija ili
Do not swallow or inject. 
Nemojte gutati niti injicirati.
White-to-off-white uniform suspension, pH 6.5 (approximately). 
Bijela do bjelkasta jednolična suspenzija, pH 6,5 (približno).
In rabbits, maximum ocular concentrations were achieved in less than one hour in most cases. 
Kod kunića, maksimalne koncentracije u oku postignute su za manje od jednog sata u većini slučajeva.
If allergic reactions are observed, treatment should be discontinued. 
Ako se opaze alergijske reakcije, liječenje se mora prekinuti.
If you experience any of the following side effects, please stop using this medicine and seek immediate medical attention as these could be signs of a reaction to the medicine. 
Ako primijetite bilo koju od slijedećih nuspojava, molimo prekinite primjenu lijeka i odmah potražite medicinsku pomoć jer ovo mogu biti znakovi reakcije na lijek.
What SIMBRINZA is and what it is used for 
Što je SIMBRINZA i za što se koristi
Should this happen, contact your doctor immediately. 
Ako se to dogodi,odmah se obratite liječniku.
They are classified according to the subsequent convention: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000) or not known (cannot be estimated from the available data). 
Razvrstane su prema sljedećoj klasifikaciji: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1000 i <1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000) ili nepoznato (ne može se procijeniti iz dostupnih podataka).
Plasma levels decline with a half-life of approximately 2-3 hours. 
Razine u plazmi opadaju s poluvijekom od otprilike 2-3 sata.
It could infect the drops. 
Može doći do inficiranja kapi.
Missed dose If a dose is missed, treatment should be continued with the next dose as planned. 
Ako se propusti jedna doza, liječenje se mora nastaviti sa sljedećom dozom kako je planirano.
Maximum human plasma concentrations are <1 ng/mL and achieved within <1 hour. 
Maksimalne koncentracije u krvi kod ljudi su <1 ng/ml i postignute unutar <1 sata.
If you stop using SIMBRINZA the pressure in your eye will not be controlled, which could lead to loss of sight. 
Ako ste prekinuli primjenu SIMBRINZE Vaš očni tlak više neće biti pod nadzorom, što može dovesti do gubitka vida.
SIMBRINZA is not intended for use by children and adolescents aged below 18 years because it has not been studied in this age group. 
SIMBRINZA nije namijenjena za primjenu u djece i adolescenata ispod 18 godina starosti zato što nije bila ispitivana u toj dobnoj skupini.
Both substances work together to reduce pressure within the eye. 
Obje tvari djeluju zajedno na snižavanje tlaka u oku.
• Severe skin reactions, including rash or redness or itching on your body or eyes 
• Teške kožne reakcije, uključujući osip ili crvenilo ili svrbež na tijelu ili očima
The only adverse reaction reported to date was hypotension. 
Jedina do sada prijavljena nuspojava je hipotenzija.
To reduce the amount of medicine that could come into the rest of the body after application of the eye drop, close your eye and apply gentle pressure to the corner of the eye next to the nose with a finger for at least 2 minutes. 
Kako bi smanjili količinu lijeka koji bi mogao prijeći u ostatak tijela nakon primjene kapi za oko, zatvorite oko i lagano pritisnite prstom kut oka okrenut nosu na najmanje 2 minute.
Do not squeeze the bottle: it is designed so that a gentle press on the bottom is all that it needs (picture 2). 
Bocu nemojte stiskati: ona je izrađena tako da samo trebate pritisnuti njeno dno (slika 2).
You should also tell your doctor if the dose of any of your current medicines is changed. 
Trebate obavijestiti svoga liječnika i ako mijenjate dozu bilo kojeg lijeka koji uzimate.
The Cmax, AUC and elimination half-life of brimonidine are similar in elderly (>65 years of age) subjects compared to young adults. 
Cmax, AUC i poluvijek eliminacije brimonidina u starijih osoba (>65 godina starosti) slični su onima u mladih odraslih osoba.
If overdose with SIMBRINZA occurs treatment should be symptomatic and supportive. 
Nastupi li predoziranje SIMBRINZOM, liječenje mora biti simptomatsko i potporno.
Ask your optometrist (optician) or pharmacist how to throw away medicines you no longer use. 
Pitajte svog optometristu (optičara) ili ljekarnika kako baciti lijekove koje više ne koristite.
Patients should be instructed to shake the bottle well before use. 
Bolesnike treba uputiti da prije uporabe dobro protresu bocu.
The recommended dose is one drop in the affected eye or eyes two times a day. 
Preporučena doza je jedna kap u oboljelo oko ili oči dva puta na dan.
If you feel abnormal eye sensation, stinging or pain in the eye after using this medicine, talk to your doctor. 
U slučaju neuobičajenog osjećaja u oku, bockanja ili boli u oku nakon primjene ovog lijeka obratite se svom liječniku.
In rats and monkeys, urinary metabolites accounted for 60 to 75% of oral or intravenous doses. 
Kod štakora i majmuna, razina metabolita u urinu bila je 60 do 75% oralne ili intravenozne doze.
Data in rats showed some biliary excretion (about 30%), primarily as metabolites. 
Podaci kod štakora pokazali su određeno izlučivanje u žuč (oko 30%), prvenstveno u obliku metabolita.
Brinzolamide is primarily eliminated in urine unchanged. 
Brinzolamid se prvenstveno eliminira u urin u nepromijenjenom obliku.
All treatment differences (SIMBRINZA versus individual components) were statistically significant with p=0.0001 or less. 
Sve razlike među lijekovima (SIMBRINZA u odnosu na pojedine komponente) bile su statistički značajne uz vrijednost p=0,0001 ili manju.
Other medicines and SIMBRINZA 
Drugi lijekovi i SIMBRINZA
Women who may become pregnant are advised to use effective contraception during SIMBRINZA treatment. 
Ženama koje mogu zatrudnjeti preporučuje se korištenje učinkovite kontracepcije tijekom liječenja SIMBRINZOM.
Throw away the bottle 4 weeks after first opening to prevent infections and use a new bottle. 
Da bi se spriječile infekcije, bočicu bacite 4 tjedna nakon prvog otvaranja i uzmite novu bočicu.
Treatment of children 2 years and above (especially those in the 2-7 age range and/or weighing <20 kg) is not recommended because of the potential for central nervous system-related side effects (see section 4.9). 
Liječenje djece od navršene druge godine nadalje (posebice one u dobnom rasponu od 2 do 7 godina i/ili težine <20 kg) se ne preporučuje zbog mogućih nuspojava povezanih sa središnjim živčanim sustavom (vidjeti dio 4.9).
Do not use SIMBRINZA unless clearly indicated by your doctor. 
Ne koristite SIMBRINZU osim u slučaju da to izričito traži Vaš liječnik.
Brinzolamide is moderately (about 60%) bound to human plasma proteins. 
Brinzolamid se umjereno (oko 60%) veže na proteine plazme kod ljudi.
1, motor dysfunction 
1, motorička disfunkcija
Visit 
Posjet
The potential for interactions must be considered in patients receiving SIMBRINZA. 
Mora se razmotriti mogućnost interakcija u bolesnika koji primaju SIMBRINZU.
The frequency of an allergic reaction to the medicine is not known (frequency cannot be estimated from the available data). 
Učestalost alergijskih reakcija na lijek nije poznata (učestalost se ne može procijeniti iz dostupnih podataka).
The IOP-lowering effect of brimonidine may be longer. 
Učinak brimonidina na sniženje IOT-a može trajati duže.
This may result in a decrease in systemic side effects and an increase in local activity (see section 4.4). 
To može rezultirati smanjenjem sistemskih nuspojava i povećanjem lokalnog djelovanja (vidjeti dio 4.4).
Given the low systemic exposure to brimonidine following topical ocular administration, it is expected that changes in plasma exposure would not be clinically relevant. 
Imajući u vidu malu sistemsku izloženost brimonidinu nakon topikalne primjene u oko, očekuje se da promjene izloženosti u plazmi ne bi bile klinički značajne.
Patients should be instructed not to swallow SIMBRINZA. 
Bolesnike se mora uputiti da ne gutaju SIMBRINZU.
It is particularly important that the medicine is not used in children under the age of 2 years (see section ‘Do not use SIMBRINZA' above) because it is unlikely to be safe. 
Posebno je važno da se ovaj lijek ne primjenjuje u djece ispod 2 godine starosti (Pogledajte dio „Nemojte primjenjivati SIMBRINZU“ iznad) zato što nije vjerojatno da je njegova primjena u toj dobi sigurna.
What SIMBRINZA is and what it is used for What you need to know before you use SIMBRINZA How to use SIMBRINZA 
Što je SIMBRINZA i za što se koristi Što morate znati prije nego počnete primjenjivati SIMBRINZU
Uncommon: hypotension Very rare: hypertension 
Manje često: hipotenzija Vrlo rijetko: hipertenzija
If you are using other eye drops as well as SIMBRINZA, wait at least five minutes between using SIMBRINZA and the other drops. 
Ako primjenjujete druge kapi za oko uz SIMBRINZU, pričekajte najmanje 5 minuta između primjene SIMBRINZE i ostalih kapi.
When nasolacrimal occlusion is used and the eyelids are closed for 2 minutes, systemic absorption is reduced. 
Primjenom nazolakrimalne okluzije i zatvaranjem vjeđa na 2 minute smanjuje se sistemska apsorpcija.
If more than one topical ophthalmic medicinal product is being used, the medicinal products must be administered at least 5 minutes apart. 
Ako se primjenjuje više od jednog topikalnog oftalmičkog lijeka, lijekovi se moraju primijeniti s najmanje 5 minuta razmaka.
This medicine contains 0.15 mg benzalkonium chloride in each 5 ml, which is equivalent to 0.03 mg/ml. 
Ovaj lijek sadrži 0,15 mg benzalkonijevog klorida u svakih 5 ml, što odgovara 0,03 mg/ml.
Do not touch your eye or eyelid, surrounding areas or other surfaces with the dropper. 
Kapaljkom ne dodirujte oko ili vjeđu, okolna područja ili druge površine.